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Search of human proteins with 6912678
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
(509 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 987 0.0
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 848 0.0
gi|39812229 karyopherin alpha 5 [Homo sapiens] 83 7e-16
gi|224589129 karyopherin 7 [Homo sapiens] 79 1e-14
gi|222144293 karyopherin alpha 1 [Homo sapiens] 78 2e-14
gi|4504901 karyopherin alpha 4 [Homo sapiens] 77 3e-14
gi|6912478 karyopherin alpha 6 [Homo sapiens] 76 8e-14
gi|34485722 karyopherin alpha 3 [Homo sapiens] 72 1e-12
gi|4504897 karyopherin alpha 2 [Homo sapiens] 69 8e-12
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 65 1e-10
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 49 8e-06
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 42 0.001
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD... 40 0.004
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD... 40 0.004
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ... 40 0.004
gi|11968009 SIL1 protein precursor [Homo sapiens] 40 0.005
gi|83641896 SIL1 protein precursor [Homo sapiens] 40 0.005
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 40 0.007
gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens] 39 0.011
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 38 0.019
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 38 0.025
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 38 0.025
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [... 38 0.025
gi|25092658 hypothetical protein LOC221927 [Homo sapiens] 38 0.025
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 37 0.043
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 37 0.043
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens] 37 0.043
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso... 37 0.056
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso... 37 0.056
gi|154090976 sterile alpha and TIR motif containing 1 [Homo sapi... 37 0.056
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 987 bits (2552), Expect = 0.0
Identities = 509/509 (100%), Positives = 509/509 (100%)
Query: 1 MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT 60
MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT
Sbjct: 1 MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT 60
Query: 61 AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA 120
AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA
Sbjct: 61 AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA 120
Query: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE
Sbjct: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
Query: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS 240
IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS
Sbjct: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS 240
Query: 241 VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID 300
VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID
Sbjct: 241 VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID 300
Query: 301 CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL
Sbjct: 301 CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
Query: 361 GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF 420
GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF
Sbjct: 361 GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF 420
Query: 421 LYDAPPNILKHVVGQFSKVLPHDSKARRLFVTSGGLKKVQEIKAEPGSLLQEYINSINSC 480
LYDAPPNILKHVVGQFSKVLPHDSKARRLFVTSGGLKKVQEIKAEPGSLLQEYINSINSC
Sbjct: 421 LYDAPPNILKHVVGQFSKVLPHDSKARRLFVTSGGLKKVQEIKAEPGSLLQEYINSINSC 480
Query: 481 YPEEIVRYYSPGYSDTLLQRVDSYQPLNN 509
YPEEIVRYYSPGYSDTLLQRVDSYQPLNN
Sbjct: 481 YPEEIVRYYSPGYSDTLLQRVDSYQPLNN 509
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 848 bits (2191), Expect = 0.0
Identities = 440/440 (100%), Positives = 440/440 (100%)
Query: 1 MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT 60
MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT
Sbjct: 1 MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQT 60
Query: 61 AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA 120
AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA
Sbjct: 61 AALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQA 120
Query: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE
Sbjct: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
Query: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS 240
IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS
Sbjct: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHS 240
Query: 241 VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID 300
VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID
Sbjct: 241 VDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVID 300
Query: 301 CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL
Sbjct: 301 CIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
Query: 361 GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF 420
GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF
Sbjct: 361 GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTYLPALEPF 420
Query: 421 LYDAPPNILKHVVGQFSKVL 440
LYDAPPNILKHVVGQFSKVL
Sbjct: 421 LYDAPPNILKHVVGQFSKVL 440
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 82.8 bits (203), Expect = 7e-16
Identities = 66/266 (24%), Positives = 120/266 (45%), Gaps = 6/266 (2%)
Query: 41 GVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYK 100
G + + LL +Q+ A ALG +A N + + V+ C+ILP L+ L NR
Sbjct: 170 GAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTT 229
Query: 101 -KAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNA 157
+ A + L + GK+ P + C L+ L L DP V WAL Y++
Sbjct: 230 TRNAVWALSNLCRGKNPPPNFSKVSPC--LNVLSRLLFSSDPDVLADVCWALSYLSDGPN 287
Query: 158 ELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQM 217
+ QAV+D+G LV + + + A A+ +I Q +++ A+ L +
Sbjct: 288 DKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHL 347
Query: 218 ILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIRE 277
+ +P ++ + +S ++ + + V++A IFPV++ L+ + +K A+ I
Sbjct: 348 LSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITN 407
Query: 278 IAK-HTPELSQLVVNAGGVAAVIDCI 302
TPE + +V G + + D +
Sbjct: 408 ATSGGTPEQIRYLVALGCIKPLCDLL 433
Score = 64.3 bits (155), Expect = 2e-10
Identities = 74/341 (21%), Positives = 144/341 (42%), Gaps = 6/341 (1%)
Query: 72 NDDLAEAVVKCDILPQLVYSLAE-QNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTL 130
N + + + K ++ + V L +N + AA+ L + + + +++ GA+
Sbjct: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175
Query: 131 VICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVP-LLVLCIQEPEIALKRIAAS 189
+ L V+E A WAL IA NAE V++ +P LL L + R A
Sbjct: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235
Query: 190 ALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVE 249
ALS++ + + + L++++ + D + + ALS +S D + V++
Sbjct: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVID 295
Query: 250 AEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNT 309
+ + ++ L D V A + I +Q+++N + ++ + S K +
Sbjct: 296 SGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESI 355
Query: 310 RLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL-GQIGRHTP 368
R + + A + AVI + P L L ++ E + AAWA+ TP
Sbjct: 356 RKEACWTVSNITAGNRAQIQAVIDANIFPVLIEIL-QKAEFRTRKEAAWAITNATSGGTP 414
Query: 369 EHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQ 409
E R + + L L ++ S+ +QV + ++NIL+
Sbjct: 415 EQIRYLVALGCIKPLCDL-LTVMDSKIVQV-ALNGLENILR 453
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/116 (22%), Positives = 54/116 (46%)
Query: 34 IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLA 93
I+ + ++GV L LL+ + A A+G + +D + ++ C LP L++ L+
Sbjct: 290 IQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLS 349
Query: 94 EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL 149
+K A + + + + QA++D L+ L+ + ++ AAWA+
Sbjct: 350 SPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAI 405
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 79.0 bits (193), Expect = 1e-14
Identities = 65/274 (23%), Positives = 124/274 (45%), Gaps = 5/274 (1%)
Query: 121 IVDCGALDTLVICLED-FDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
+++ G + +V L+ P ++ AAWAL IA +E ++AVV+ GA+ L+ +
Sbjct: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168
Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237
+A+ A AL +IA PE V+ + A+ HL +I +P + I LS +
Sbjct: 169 NVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLC 227
Query: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297
++ +I P +L L+ +D V +A + + + + VVN G +
Sbjct: 228 RNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPR 287
Query: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357
++ + S + N P + +G + ++ + I G+ + L + + I+ AA
Sbjct: 288 LVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQ-MAIDAGMLNVLPQLLQHNKPSIQKEAA 346
Query: 358 WALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTE 391
WAL + H + + + LP L++L + E
Sbjct: 347 WALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGE 380
Score = 58.5 bits (140), Expect = 1e-08
Identities = 53/253 (20%), Positives = 106/253 (41%), Gaps = 4/253 (1%)
Query: 29 TRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQL 88
T Q ++ + L+ L V +Q A ALG +A + + V+ + +P L
Sbjct: 145 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQ-AVWALGNIAGDGPEFRDNVITSNAIPHL 203
Query: 89 VYSLAEQN--RFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
+ ++ F + + +P V L L+ L+ D V A
Sbjct: 204 LALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVK-QILPALLHLLQHQDSEVLSDAC 262
Query: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVV 206
WAL Y+ + + VV+ G +P LV+ + E+ + + + +I + E Q +
Sbjct: 263 WALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAI 322
Query: 207 DAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEY 266
DAG + L Q++ + ++ + ALS V+ + ++ ++ P ++ LK+ +
Sbjct: 323 DAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFK 382
Query: 267 VKKNASTLIREIA 279
V+K A ++ A
Sbjct: 383 VQKEAVWMVANFA 395
Score = 58.2 bits (139), Expect = 2e-08
Identities = 70/307 (22%), Positives = 130/307 (42%), Gaps = 13/307 (4%)
Query: 59 QTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFY---KKAAAFVLRAVGKHSP 115
Q A L+ + + V++ ++P++V L ++ Y + AA+ L + +
Sbjct: 89 QATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFL--KSSLYPCLQFEAAWALTNIASGTS 146
Query: 116 QLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVP-LLVL 174
+ +A+V+ GA+ L+ L + V E A WAL IA E V+ + A+P LL L
Sbjct: 147 EQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLAL 206
Query: 175 CIQEPEIALKRIAASALSDIAKH-SPELAQTVVD--AGAVAHLAQMILNPDAKLKHQILS 231
I R LS++ ++ +P T V A+ HL Q + D+++
Sbjct: 207 ISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ---HQDSEVLSDACW 263
Query: 232 ALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVN 291
ALS ++ S VV + P ++ + + V + + I T E +Q+ ++
Sbjct: 264 ALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAID 323
Query: 292 AGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDH 351
AG + + + K + + L VAA + ++ +P L V L + E
Sbjct: 324 AGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPL-VALLKNGEFK 382
Query: 352 IKAAAAW 358
++ A W
Sbjct: 383 VQKEAVW 389
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/163 (23%), Positives = 65/163 (39%), Gaps = 1/163 (0%)
Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDK-DEYVKKNASTLIREIAKHTPELSQLV 289
+A +S+ ++V+EA + P ++ LK ++ A+ + IA T E ++ V
Sbjct: 93 TARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAV 152
Query: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPE 349
V G + +I+ + S + LG +A VI S +P L +S
Sbjct: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLP 212
Query: 350 DHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTES 392
W L + R+ + AV LP LL L +S
Sbjct: 213 ITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDS 255
>gi|222144293 karyopherin alpha 1 [Homo sapiens]
Length = 538
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/239 (25%), Positives = 110/239 (46%), Gaps = 5/239 (2%)
Query: 40 AGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRF- 98
AG + + LL +Q+ A ALG +A + + V+ C+ILP L+ ++QNR
Sbjct: 168 AGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLT 227
Query: 99 YKKAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHN 156
+ A + L + GK P + C L+ L L D V A WAL Y++
Sbjct: 228 MTRNAVWALSNLCRGKSPPPEFAKVSPC--LNVLSWLLFVSDTDVLADACWALSYLSDGP 285
Query: 157 AELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQ 216
+ QAV+DAG LV + + + A A+ +I Q +++ A+ L
Sbjct: 286 NDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLH 345
Query: 217 MILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLI 275
++ +P +K + +S ++ + + V++A IFP +++ L+ + +K A+ I
Sbjct: 346 LLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 404
Score = 62.0 bits (149), Expect = 1e-09
Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 7/198 (3%)
Query: 43 MSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKA 102
+++L LL + A AL L++ +D +AV+ + +LV L + K
Sbjct: 256 LNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDY---KV 312
Query: 103 AAFVLRAVGK---HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAEL 159
+ LRAVG Q I++C AL +L+ L +K+ A W + I N
Sbjct: 313 VSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQ 372
Query: 160 SQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVAHLAQMI 218
Q V+DA P L+ +Q E ++ AA A+++ S E + +V+ G + L ++
Sbjct: 373 IQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLL 432
Query: 219 LNPDAKLKHQILSALSQV 236
D+K+ L+ L +
Sbjct: 433 TVMDSKIVQVALNGLENI 450
Score = 57.4 bits (137), Expect = 3e-08
Identities = 53/248 (21%), Positives = 101/248 (40%), Gaps = 2/248 (0%)
Query: 145 AAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
+AW L IA N+ ++ V+ AGAVP+ + + ++ A AL +IA S
Sbjct: 147 SAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDY 206
Query: 205 VVDAGAVAHLAQMILNPDA-KLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDK 263
V+D + L Q+ + + + ALS + + E + V+ L
Sbjct: 207 VLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266
Query: 264 DEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAH 323
D V +A + ++ + Q V++AG +++ + P + +G +
Sbjct: 267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVT- 325
Query: 324 SENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVL 383
+++ VI++ Q + L P++ IK A W + I + V N P L
Sbjct: 326 GDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPAL 385
Query: 384 LSLYMSTE 391
+S+ + E
Sbjct: 386 ISILQTAE 393
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/301 (19%), Positives = 119/301 (39%), Gaps = 2/301 (0%)
Query: 12 QYQKARTQFVQMVAELATRPQNIETLQNAGVMS-LLRTLLLDVVPTIQQTAALALGRLAN 70
+ Q + TQ + + P E + GV++ + L T+Q +A L +A+
Sbjct: 97 EQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIAS 156
Query: 71 YNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTL 130
N V++ +P + L+ + ++ A + L + S ++DC L L
Sbjct: 157 GNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPL 216
Query: 131 VICLEDFDP-GVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAAS 189
+ + + A WAL + R + + + + +L + + + A
Sbjct: 217 LQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACW 276
Query: 190 ALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVE 249
ALS ++ + Q V+DAG L +++++ D K+ L A+ + ++++
Sbjct: 277 ALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILN 336
Query: 250 AEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNT 309
+L L E +KK A I I Q V++A A+I + + + T
Sbjct: 337 CSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRT 396
Query: 310 R 310
R
Sbjct: 397 R 397
Score = 47.4 bits (111), Expect = 3e-05
Identities = 34/164 (20%), Positives = 74/164 (45%), Gaps = 1/164 (0%)
Query: 34 IETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLA 93
I+ + +AGV L LL+ + A A+G + +D + ++ C L L++ L+
Sbjct: 289 IQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLS 348
Query: 94 EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL-RYI 152
KK A + + + + Q ++D L+ L+ + ++ AAWA+
Sbjct: 349 SPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNAT 408
Query: 153 ARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK 196
+ +AE + +V+ G + L + + + ++A + L +I +
Sbjct: 409 SGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILR 452
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 77.4 bits (189), Expect = 3e-14
Identities = 62/269 (23%), Positives = 113/269 (42%), Gaps = 5/269 (1%)
Query: 121 IVDCGALDTLVICLE-DFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
++ G L LV CLE D +P ++ AAWAL IA +E +QAVV + AVPL + + P
Sbjct: 110 LIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSP 169
Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237
+ A AL +I P+ V+ G V L I +P + + + +
Sbjct: 170 HQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVMVNLC 228
Query: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297
+H M EI P + + D + + + + E Q+V+++G V
Sbjct: 229 RHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPH 288
Query: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357
++ + + + + +G + ++ V+ + L+ P++ I A
Sbjct: 289 LVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLT-HPKEKINKEAV 347
Query: 358 WALGQIGRHTPEHARAVAVTNTLPVLLSL 386
W L I + +AV N +P+++ L
Sbjct: 348 WFLSNITAGNQQQVQAVIDANLVPMIIHL 376
Score = 74.7 bits (182), Expect = 2e-13
Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 46/304 (15%)
Query: 21 VQMVAELATRPQN--IETLQNAGVMSLL-RTLLLDVVPTIQQTAALALGRLANYNDDLAE 77
VQ +L + +N I+ L +G++ +L L D P++Q AA AL +A+ + +
Sbjct: 92 VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 151
Query: 78 AVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGA----------- 126
AVV+ + +P + L ++ + A + L + PQ ++ G
Sbjct: 152 AVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS 211
Query: 127 --------------------------------LDTLVICLEDFDPGVKEAAAWALRYIAR 154
L L + + D + WAL Y+
Sbjct: 212 IPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD 271
Query: 155 HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHL 214
E Q V+D+G VP LV + E+ ++ A A+ +I + E Q V++ A++H
Sbjct: 272 AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHF 331
Query: 215 AQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTL 274
++ +P K+ + + LS ++ + + V++A + P+++ L D +K A+
Sbjct: 332 PALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWA 391
Query: 275 IREI 278
I +
Sbjct: 392 ISNL 395
Score = 42.0 bits (97), Expect = 0.001
Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 2/137 (1%)
Query: 255 VVLTCLKDK-DEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPG 313
VV+ K+K DE++ K + +I + + V + A++ S +L
Sbjct: 32 VVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSA 91
Query: 314 IMMLGYVAAHSENLAMAVIISKGV-PQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHAR 372
+ + + N + +I G+ P L CL + ++ AAWAL I T E +
Sbjct: 92 VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 151
Query: 373 AVAVTNTLPVLLSLYMS 389
AV +N +P+ L L S
Sbjct: 152 AVVQSNAVPLFLRLLHS 168
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 75.9 bits (185), Expect = 8e-14
Identities = 65/275 (23%), Positives = 121/275 (44%), Gaps = 6/275 (2%)
Query: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
Q + + AG + + LL +Q+ A ALG +A + + V+ C IL L+
Sbjct: 158 QQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTL 217
Query: 92 LAEQNRF-YKKAAAFVLRAV--GKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWA 148
L + R + A + L + GK+ P + C L L L D + A WA
Sbjct: 218 LTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPC--LPVLSRLLFSSDSDLLADACWA 275
Query: 149 LRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDA 208
L Y++ E QAV+D+G LV + + + A A+ +I Q +++
Sbjct: 276 LSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNC 335
Query: 209 GAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVK 268
A+ L ++ +P ++ + +S ++ + + V++A IFPV++ L+ + +
Sbjct: 336 SALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTR 395
Query: 269 KNASTLIREIAK-HTPELSQLVVNAGGVAAVIDCI 302
K A+ I TPE + +V+ G + + D +
Sbjct: 396 KEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLL 430
Score = 65.9 bits (159), Expect = 9e-11
Identities = 69/312 (22%), Positives = 138/312 (44%), Gaps = 11/312 (3%)
Query: 103 AAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQA 162
AA+ L + + Q + +++ GA+ + L V+E A WAL IA ++
Sbjct: 145 AAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDY 204
Query: 163 VVDAGAV-PLLVLCIQEPEIALKRIAASALSDIAKHS---PELAQTVVDAGAVAHLAQMI 218
V++ + PLL L + + + R A ALS++ + PE A+ + + L++++
Sbjct: 205 VLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKV---SPCLPVLSRLL 261
Query: 219 LNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREI 278
+ D+ L ALS +S + + V+++ + ++ L D V A + I
Sbjct: 262 FSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNI 321
Query: 279 AKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVP 338
+Q+++N + ++ + S K + R + + A + AVI + P
Sbjct: 322 VTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFP 381
Query: 339 QLSVCLSEEPEDHIKAAAAWAL-GQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQ 397
L + + ++ E + AAWA+ TPE R + + L L ++ S+ +Q
Sbjct: 382 VL-IEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDL-LTVMDSKIVQ 439
Query: 398 VKSKKAIKNILQ 409
V + ++NIL+
Sbjct: 440 V-ALNGLENILR 450
Score = 59.7 bits (143), Expect = 6e-09
Identities = 53/256 (20%), Positives = 104/256 (40%), Gaps = 1/256 (0%)
Query: 56 TIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSP 115
T+Q AA AL +A+ + V++ +P + L ++ A + L + S
Sbjct: 140 TLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSS 199
Query: 116 QLAQAIVDCGALDTLVICL-EDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVL 174
+++C L+ L+ L + + A WAL + R + + +P+L
Sbjct: 200 VCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSR 259
Query: 175 CIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALS 234
+ + L A ALS ++ E Q V+D+G L +++++ D K+ L A+
Sbjct: 260 LLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVG 319
Query: 235 QVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGG 294
+ ++++ P +L L E ++K A I I Q V++A
Sbjct: 320 NIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANI 379
Query: 295 VAAVIDCIGSCKGNTR 310
+I+ + + TR
Sbjct: 380 FPVLIEILQKAEFRTR 395
>gi|34485722 karyopherin alpha 3 [Homo sapiens]
Length = 521
Score = 72.0 bits (175), Expect = 1e-12
Identities = 63/304 (20%), Positives = 124/304 (40%), Gaps = 46/304 (15%)
Query: 21 VQMVAELATRPQN--IETLQNAGVMSLL-RTLLLDVVPTIQQTAALALGRLANYNDDLAE 77
VQ +L + +N I+ L +G++ +L + L D P++Q AA AL +A+ +
Sbjct: 92 VQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQ 151
Query: 78 AVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGA----------- 126
AVV+ + +P + L ++ + A + L + PQ ++ G
Sbjct: 152 AVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS 211
Query: 127 --------------------------------LDTLVICLEDFDPGVKEAAAWALRYIAR 154
L L + + D + WAL Y+
Sbjct: 212 IPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTD 271
Query: 155 HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHL 214
E Q V+D+G VP LV + E+ ++ A A+ +I + E Q V++ ++H
Sbjct: 272 GGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHF 331
Query: 215 AQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTL 274
++ +P K+ + + LS ++ + + V++A + P+++ L D +K A+
Sbjct: 332 PNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWA 391
Query: 275 IREI 278
I +
Sbjct: 392 ISNL 395
Score = 68.6 bits (166), Expect = 1e-11
Identities = 59/267 (22%), Positives = 111/267 (41%), Gaps = 5/267 (1%)
Query: 121 IVDCGALDTLVICLE-DFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
++ G L LV CLE D +P ++ AAWAL IA + +QAVV + AVPL + ++ P
Sbjct: 110 LIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSP 169
Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237
+ A AL +I P+ V+ G V L I +P + + + +
Sbjct: 170 HQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVIVNLC 228
Query: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297
++ M EI P + + D + + + + E Q+V+++G V
Sbjct: 229 RNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPF 288
Query: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357
++ + + + + +G + ++ V+ + LS P++ I A
Sbjct: 289 LVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLS-HPKEKINKEAV 347
Query: 358 WALGQIGRHTPEHARAVAVTNTLPVLL 384
W L I + +AV +P+++
Sbjct: 348 WFLSNITAGNQQQVQAVIDAGLIPMII 374
Score = 35.4 bits (80), Expect = 0.12
Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Query: 332 IISKGV-PQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMS 389
+I G+ P L CL + ++ AAWAL I T +AV +N +P+ L L S
Sbjct: 110 LIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRS 168
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 69.3 bits (168), Expect = 8e-12
Identities = 56/247 (22%), Positives = 100/247 (40%), Gaps = 6/247 (2%)
Query: 145 AAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
+AWAL IA +E ++AVVD GA+P + + P + A AL +IA
Sbjct: 140 SAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDL 199
Query: 205 VVDAGAVAHLAQMILNPDAK-----LKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTC 259
V+ GAV L ++ PD + LS + ++ + +I P ++
Sbjct: 200 VIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRL 259
Query: 260 LKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGY 319
L D V + I + E +VV G V ++ +G+ + P + +G
Sbjct: 260 LHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGN 319
Query: 320 VAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNT 379
+ ++ V+I G + L P+ +I+ A W + I + + V
Sbjct: 320 IVTGTDEQTQ-VVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGL 378
Query: 380 LPVLLSL 386
+P L+S+
Sbjct: 379 VPFLVSV 385
Score = 68.6 bits (166), Expect = 1e-11
Identities = 58/245 (23%), Positives = 100/245 (40%), Gaps = 5/245 (2%)
Query: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
+ + + + G + +LL I + A ALG +A + V+K + L+
Sbjct: 153 EQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL 212
Query: 92 LAEQNRF-----YKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
LA + Y + + L + ++ L TLV L DP V
Sbjct: 213 LAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTC 272
Query: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVV 206
WA+ Y+ E VV G VP LV + E+ + A A+ +I + E Q V+
Sbjct: 273 WAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVI 332
Query: 207 DAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEY 266
DAGA+A ++ NP ++ + +S ++ D + VV + P +++ L D
Sbjct: 333 DAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFK 392
Query: 267 VKKNA 271
+K A
Sbjct: 393 TQKEA 397
Score = 55.8 bits (133), Expect = 9e-08
Identities = 58/288 (20%), Positives = 121/288 (42%), Gaps = 7/288 (2%)
Query: 79 VVKCDILPQLVYSLAEQNRF-YKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDF 137
+++ ++P+ V L + + +A+ L + + + +A+VD GA+ + L
Sbjct: 115 IIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP 174
Query: 138 DPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIA-----LKRIAASALS 192
+ E A WAL IA + V+ GAV L+ + P+++ R LS
Sbjct: 175 HAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS 234
Query: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
++ ++ + L +++ + D ++ A+S ++ + MVV+ +
Sbjct: 235 NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGV 294
Query: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLP 312
P ++ L + + A I I T E +Q+V++AG +A + + K N +
Sbjct: 295 VPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKE 354
Query: 313 GIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
+ + A ++ V+ VP L LS + + + A WA+
Sbjct: 355 ATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLS-KADFKTQKEAVWAV 401
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/259 (23%), Positives = 107/259 (41%), Gaps = 13/259 (5%)
Query: 42 VMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKK 101
++ L LL P + A+ L + ++ VVK ++PQLV L
Sbjct: 252 ILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVT 311
Query: 102 AAAFVLRAVGK---HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAE 158
A LRA+G + + Q ++D GAL L + +++ A W + I +
Sbjct: 312 PA---LRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQD 368
Query: 159 LSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVAHLAQM 217
Q VV+ G VP LV + + + ++ A A+++ + E +V G + L +
Sbjct: 369 QIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNL 428
Query: 218 ILNPDAKLKHQILSALSQVSKHSVDLAE------MVVEAEIFPVVLTCLKDKDEYVKKNA 271
+ D K+ IL A+S + + + L E M+ E + ++E V K +
Sbjct: 429 LTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKAS 488
Query: 272 STLIREIAKHTPELSQLVV 290
+LI + E Q VV
Sbjct: 489 LSLIEKYFSVEEEEDQNVV 507
Score = 43.1 bits (100), Expect = 6e-04
Identities = 44/182 (24%), Positives = 80/182 (43%), Gaps = 7/182 (3%)
Query: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
+V G + LV L + + A A+ I E +Q V+DAGA+ + + P+
Sbjct: 289 VVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPK 348
Query: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKL-KHQILSALSQVSKH 239
+++ A +S+I + Q VV+ G V L ++ D K K + + + S
Sbjct: 349 TNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGG 408
Query: 240 SVDLAEMVVEAEIFPVVLTCLKDKDE---YVKKNASTLIREIAK---HTPELSQLVVNAG 293
+V+ +V I ++ L KD V +A + I + A+ T +LS ++ G
Sbjct: 409 TVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECG 468
Query: 294 GV 295
G+
Sbjct: 469 GL 470
Score = 35.4 bits (80), Expect = 0.12
Identities = 36/174 (20%), Positives = 68/174 (39%), Gaps = 1/174 (0%)
Query: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
+ I + GV+ L LL I A A+G + D+ + V+ L
Sbjct: 284 ERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSL 343
Query: 92 LAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL-R 150
L +K A + + + Q +V+ G + LV L D ++ A WA+
Sbjct: 344 LTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTN 403
Query: 151 YIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
Y + E +V G + L+ + + + + A+S+I + + +L +T
Sbjct: 404 YTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGET 457
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 65.1 bits (157), Expect = 1e-10
Identities = 54/236 (22%), Positives = 113/236 (47%), Gaps = 6/236 (2%)
Query: 172 LVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILS 231
LV +Q + +A +L I + + + ++DAG + L ++ + KL+ + +
Sbjct: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693
Query: 232 ALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVN 291
LS +S H +VEA P ++ L + V + ++ +IA+ E ++
Sbjct: 694 LLSNISTHK-SAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC--ENKDVIAK 750
Query: 292 AGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDH 351
G+ ++I+ + N + + + + +EN AV KG+P L LS + D
Sbjct: 751 YNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD-SDV 809
Query: 352 IKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNI 407
+KA ++ A+ ++GR E A+A+ +P L++L+ + S +Q+K A++++
Sbjct: 810 LKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQIS--VQMKGAMAVESL 863
Score = 60.8 bits (146), Expect = 3e-09
Identities = 68/358 (18%), Positives = 148/358 (41%), Gaps = 13/358 (3%)
Query: 15 KARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDD 74
K + + V +++ ++T + L AG + L LL+ P + A+ L +A +
Sbjct: 686 KLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENK 745
Query: 75 LAEAVVKCDILPQLV--YSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVI 132
+ + K + +P L+ +L +N + +G + Q +A+ + L L+
Sbjct: 746 --DVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQ--RAVREHKGLPYLIR 801
Query: 133 CLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALS 192
L +K ++ A+ + R N E+ A+ GA+P LV + +I+++ A A+
Sbjct: 802 FLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVE 861
Query: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
+A H+ + + ++ +L +++ +K Q AL ++ ++ + + E
Sbjct: 862 SLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIG 921
Query: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDC--IGSCKGNTR 310
+ ++ L ++ + ++K + + G+A ++ I + T
Sbjct: 922 YSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISTIAEGTL 981
Query: 311 LPGIMMLGYV---AAHSEN--LAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQI 363
L I +G + AH+ N V+ P L L P +IK A++L I
Sbjct: 982 LSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLACI 1039
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 49.3 bits (116), Expect = 8e-06
Identities = 74/329 (22%), Positives = 131/329 (39%), Gaps = 53/329 (16%)
Query: 120 AIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
AI D G L+ L+ LE + K + L+ I+ HN ++ Q +VD G +P++V + P
Sbjct: 489 AIRDVGGLEVLINLLETDEVKCKIGSLKILKEIS-HNPQIRQNIVDLGGLPIMVNILDSP 547
Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKH 239
+LK +AA ++++AK + V G + L ++
Sbjct: 548 HKSLKCLAAETIANVAKFK-RARRVVRQHGGITKLVALL--------------------- 585
Query: 240 SVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAK-HTPELSQLVVNAGGVAAV 298
D A + P + + +D V + + + +K HT + + + AGG+ +
Sbjct: 586 --DCAHDSTK----PAQSSLYEARDVEVARCGALALWSCSKSHTNK--EAIRKAGGIPLL 637
Query: 299 IDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAW 358
+ + N +P + L A EN A+ + + L L+ E E ++ A
Sbjct: 638 ARLLKTSHENMLIPVVGTL-QECASEENYRAAIKAERIIENLVKNLNSENE-QLQEHCAM 695
Query: 359 ALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNILQKCTY----- 413
A+ Q E V + L L SL +T++ E L A+ + KC+
Sbjct: 696 AIYQCA-EDKETRDLVRLHGGLKPLASLLNNTDNKERL-----AAVTGAIWKCSISKENV 749
Query: 414 --------LPALEPFLYDAPPNILKHVVG 434
+ L L D P +L +VVG
Sbjct: 750 TKFREYKAIETLVGLLTDQPEEVLVNVVG 778
Score = 38.9 bits (89), Expect = 0.011
Identities = 56/291 (19%), Positives = 117/291 (40%), Gaps = 20/291 (6%)
Query: 87 QLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
+++ +L E + K + + H+PQ+ Q IVD G L +V L+ +K AA
Sbjct: 497 EVLINLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAA 556
Query: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCI---------------QEPEIALKRIAASAL 191
+ +A+ + V G + LV + + ++ + R A AL
Sbjct: 557 ETIANVAKFK-RARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALAL 615
Query: 192 SDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAE 251
+K S + + AG + LA+++ + ++ L + + A + E
Sbjct: 616 WSCSK-SHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAE-R 673
Query: 252 IFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRL 311
I ++ L ++E ++++ + I + A+ E LV GG+ + + + RL
Sbjct: 674 IIENLVKNLNSENEQLQEHCAMAIYQCAE-DKETRDLVRLHGGLKPLASLLNNTDNKERL 732
Query: 312 PGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQ 362
+ + + S+ K + L L+++PE+ + ALG+
Sbjct: 733 AAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEE-VLVNVVGALGE 782
Score = 31.2 bits (69), Expect = 2.3
Identities = 47/216 (21%), Positives = 84/216 (38%), Gaps = 4/216 (1%)
Query: 24 VAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVK-C 82
V A P+++ + + LL +LL + P ++ +AA AL D E V
Sbjct: 821 VGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFV 880
Query: 83 DILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVK 142
L +V L N+ + + + K LA I D G + L + ++
Sbjct: 881 GGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLA-VITDHGVVPLLSKLANTNNNKLR 939
Query: 143 EAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELA 202
A A+ A + AV LV ++ + + R A AL +++ +
Sbjct: 940 HHLAEAISRCCMWGRN-RVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCI 998
Query: 203 QTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSK 238
T+ + GAV L M+ +PD L+ +S + +
Sbjct: 999 -TMHENGAVKLLLDMVGSPDQDLQEAAAGCISNIRR 1033
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 42.0 bits (97), Expect = 0.001
Identities = 60/270 (22%), Positives = 115/270 (42%), Gaps = 37/270 (13%)
Query: 21 VQMVAELATRPQNIETL----QNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLA 76
++ +A +A ++++T+ Q G+ LL +P IQ+ AA A+ + A Y+ +
Sbjct: 251 IEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAA-YDPENR 309
Query: 77 EAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLED 136
+ + ++ LV L +N K AA+ + A+ ++S ++ + + L+ L+
Sbjct: 310 KLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSG--SKDFFNNQGIPQLIQLLKS 367
Query: 137 FDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK 196
+ V+EAAA AL + N + A +A + L+ + AA+ L+++A
Sbjct: 368 DNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNMAM 427
Query: 197 HSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPV- 255
P L I N D + H I+S L + A + V A V
Sbjct: 428 QEP--------------LRLNIQNHD--IMHAIISPLRSANTVVQSKAALAVTATACDVE 471
Query: 256 -------------VLTCLKDKDEYVKKNAS 272
++ L+ K++ V+K+AS
Sbjct: 472 ARTELRNSGGLEPLVELLRSKNDEVRKHAS 501
Score = 35.8 bits (81), Expect = 0.095
Identities = 69/328 (21%), Positives = 135/328 (41%), Gaps = 14/328 (4%)
Query: 37 LQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDI-LPQLVYSLA-- 93
LQ + + LL P IQ A LG +AN D + +++ + L L+ L
Sbjct: 187 LQELNAIPPILDLLKSEYPVIQLLALKTLGVIAN--DKESRTMLRDNQGLDHLIKILETK 244
Query: 94 EQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFD-PGVKEAAAWALRYI 152
E N + +A A + + + I G L L+ E+ P +++ AA A+
Sbjct: 245 ELNDLHIEALAVIANCLEDMDTMVQ--IQQTGGLKKLLSFAENSTIPDIQKNAAKAITKA 302
Query: 153 ARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVA 212
A ++ E + + LV + K A+ A+S + ++S ++ + +
Sbjct: 303 A-YDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSG--SKDFFNNQGIP 359
Query: 213 HLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNAS 272
L Q++ + + +++ AL+ ++ + A EA+ ++ L K + NA+
Sbjct: 360 QLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAA 419
Query: 273 TLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVI 332
T++ +A P L + N + A+I + S NT + L A + A +
Sbjct: 420 TVLTNMAMQEP-LRLNIQNHDIMHAIISPLRS--ANTVVQSKAALAVTATACDVEARTEL 476
Query: 333 ISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
+ G + V L D ++ A+WA+
Sbjct: 477 RNSGGLEPLVELLRSKNDEVRKHASWAV 504
Score = 34.7 bits (78), Expect = 0.21
Identities = 60/300 (20%), Positives = 127/300 (42%), Gaps = 20/300 (6%)
Query: 163 VVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPD 222
++++ +VL + PE + A A+ A E T+++ GAV L +++ + D
Sbjct: 21 MIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHED 80
Query: 223 AKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNAST--LIREIAK 280
K+ + + + + + D+ +++ E ++ V+ L ++E V ++ L A+
Sbjct: 81 -KIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAE 139
Query: 281 HTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQL 340
+T ++ + GG+ +I + S + + + + + + A ++ P L
Sbjct: 140 YTSKVQ--IFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAKLQELNAIPPIL 197
Query: 341 SVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKS 400
+ SE P I+ A LG I + +R + N L + T+ DL +++
Sbjct: 198 DLLKSEYPV--IQLLALKTLGVIA--NDKESRTMLRDNQGLDHLIKILETKELNDLHIEA 253
Query: 401 KKAIKNIL---------QKCTYLPALEPFLYDAP-PNILKHVVGQFSKVLPHDSKARRLF 450
I N L Q+ L L F ++ P+I K+ +K +D + R+LF
Sbjct: 254 LAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKA-AYDPENRKLF 312
>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 40.4 bits (93), Expect = 0.004
Identities = 52/251 (20%), Positives = 108/251 (43%), Gaps = 22/251 (8%)
Query: 168 AVPLLVLCIQEPEIALKRIAASALS-----DIAKHS-PELAQTVVDAGAVAHLAQMILNP 221
A P V + EP LK + ++ ++A + PEL + + D Q+++N
Sbjct: 117 AHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDED------QVVVNK 170
Query: 222 DAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKH 281
A + HQ+ + + S+H++ + +V A +V T D + + + ++ H
Sbjct: 171 AAVMVHQL--SKKEASRHAIMRSPQMVSA----IVRTMQNTNDVETARCTAGTLHNLSHH 224
Query: 282 TPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLS 341
L + +GG+ A++ +GS + I L + H E MAV ++ G+ ++
Sbjct: 225 REGLLA-IFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMV 283
Query: 342 VCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSK 401
L++ + A QI + + ++ + + + P L M T + E L +
Sbjct: 284 ALLNKTNVKFL--AITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTS 341
Query: 402 KAIKNILQKCT 412
+ +K +L C+
Sbjct: 342 RVLK-VLSVCS 351
Score = 31.2 bits (69), Expect = 2.3
Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%)
Query: 141 VKEAAAWALRYIAR--HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHS 198
+ E AL +AR HN + + + +PL V + P ++R+AA L ++A+
Sbjct: 569 IVEGCTGALHILARDVHNRIVIRGL---NTIPLFVQLLYSPIENIQRVAAGVLCELAQ-D 624
Query: 199 PELAQTVVDAGAVAHLAQMI 218
E A+ + GA A L +++
Sbjct: 625 KEAAEAIEAEGATAPLTELL 644
Score = 30.4 bits (67), Expect = 4.0
Identities = 46/191 (24%), Positives = 81/191 (42%), Gaps = 21/191 (10%)
Query: 120 AIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
AIV+ G + L + L D + + W LR ++ +A Q ++ G + LV +
Sbjct: 356 AIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS--DAATKQEGME-GLLGTLVQLLGSD 412
Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAK--LKHQILSALSQV- 236
+I + AA LS++ ++ + V G + L + +L + + + AL +
Sbjct: 413 DINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLT 472
Query: 237 SKH-SVDLAEMVVEAEI-FPVVLTCLKDKDEYVKKNAST-LIREI----AKHT------- 282
S+H ++A+ V PVV+ L + A+ LIR + A H
Sbjct: 473 SRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGA 532
Query: 283 -PELSQLVVNA 292
P L QL+V A
Sbjct: 533 IPRLVQLLVRA 543
>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 40.4 bits (93), Expect = 0.004
Identities = 52/251 (20%), Positives = 108/251 (43%), Gaps = 22/251 (8%)
Query: 168 AVPLLVLCIQEPEIALKRIAASALS-----DIAKHS-PELAQTVVDAGAVAHLAQMILNP 221
A P V + EP LK + ++ ++A + PEL + + D Q+++N
Sbjct: 117 AHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDED------QVVVNK 170
Query: 222 DAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKH 281
A + HQ+ + + S+H++ + +V A +V T D + + + ++ H
Sbjct: 171 AAVMVHQL--SKKEASRHAIMRSPQMVSA----IVRTMQNTNDVETARCTAGTLHNLSHH 224
Query: 282 TPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLS 341
L + +GG+ A++ +GS + I L + H E MAV ++ G+ ++
Sbjct: 225 REGLLA-IFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMV 283
Query: 342 VCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSK 401
L++ + A QI + + ++ + + + P L M T + E L +
Sbjct: 284 ALLNKTNVKFL--AITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTS 341
Query: 402 KAIKNILQKCT 412
+ +K +L C+
Sbjct: 342 RVLK-VLSVCS 351
Score = 31.2 bits (69), Expect = 2.3
Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%)
Query: 141 VKEAAAWALRYIAR--HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHS 198
+ E AL +AR HN + + + +PL V + P ++R+AA L ++A+
Sbjct: 569 IVEGCTGALHILARDVHNRIVIRGL---NTIPLFVQLLYSPIENIQRVAAGVLCELAQ-D 624
Query: 199 PELAQTVVDAGAVAHLAQMI 218
E A+ + GA A L +++
Sbjct: 625 KEAAEAIEAEGATAPLTELL 644
Score = 30.4 bits (67), Expect = 4.0
Identities = 46/191 (24%), Positives = 81/191 (42%), Gaps = 21/191 (10%)
Query: 120 AIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
AIV+ G + L + L D + + W LR ++ +A Q ++ G + LV +
Sbjct: 356 AIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS--DAATKQEGME-GLLGTLVQLLGSD 412
Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAK--LKHQILSALSQV- 236
+I + AA LS++ ++ + V G + L + +L + + + AL +
Sbjct: 413 DINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLT 472
Query: 237 SKH-SVDLAEMVVEAEI-FPVVLTCLKDKDEYVKKNAST-LIREI----AKHT------- 282
S+H ++A+ V PVV+ L + A+ LIR + A H
Sbjct: 473 SRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGA 532
Query: 283 -PELSQLVVNA 292
P L QL+V A
Sbjct: 533 IPRLVQLLVRA 543
>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 40.4 bits (93), Expect = 0.004
Identities = 52/251 (20%), Positives = 108/251 (43%), Gaps = 22/251 (8%)
Query: 168 AVPLLVLCIQEPEIALKRIAASALS-----DIAKHS-PELAQTVVDAGAVAHLAQMILNP 221
A P V + EP LK + ++ ++A + PEL + + D Q+++N
Sbjct: 117 AHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDED------QVVVNK 170
Query: 222 DAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKH 281
A + HQ+ + + S+H++ + +V A +V T D + + + ++ H
Sbjct: 171 AAVMVHQL--SKKEASRHAIMRSPQMVSA----IVRTMQNTNDVETARCTAGTLHNLSHH 224
Query: 282 TPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLS 341
L + +GG+ A++ +GS + I L + H E MAV ++ G+ ++
Sbjct: 225 REGLLA-IFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMV 283
Query: 342 VCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSK 401
L++ + A QI + + ++ + + + P L M T + E L +
Sbjct: 284 ALLNKTNVKFL--AITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTS 341
Query: 402 KAIKNILQKCT 412
+ +K +L C+
Sbjct: 342 RVLK-VLSVCS 351
Score = 31.2 bits (69), Expect = 2.3
Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%)
Query: 141 VKEAAAWALRYIAR--HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHS 198
+ E AL +AR HN + + + +PL V + P ++R+AA L ++A+
Sbjct: 569 IVEGCTGALHILARDVHNRIVIRGL---NTIPLFVQLLYSPIENIQRVAAGVLCELAQ-D 624
Query: 199 PELAQTVVDAGAVAHLAQMI 218
E A+ + GA A L +++
Sbjct: 625 KEAAEAIEAEGATAPLTELL 644
Score = 30.4 bits (67), Expect = 4.0
Identities = 46/191 (24%), Positives = 81/191 (42%), Gaps = 21/191 (10%)
Query: 120 AIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179
AIV+ G + L + L D + + W LR ++ +A Q ++ G + LV +
Sbjct: 356 AIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLS--DAATKQEGME-GLLGTLVQLLGSD 412
Query: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAK--LKHQILSALSQV- 236
+I + AA LS++ ++ + V G + L + +L + + + AL +
Sbjct: 413 DINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLT 472
Query: 237 SKH-SVDLAEMVVEAEI-FPVVLTCLKDKDEYVKKNAST-LIREI----AKHT------- 282
S+H ++A+ V PVV+ L + A+ LIR + A H
Sbjct: 473 SRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGA 532
Query: 283 -PELSQLVVNA 292
P L QL+V A
Sbjct: 533 IPRLVQLLVRA 543
>gi|11968009 SIL1 protein precursor [Homo sapiens]
Length = 461
Score = 40.0 bits (92), Expect = 0.005
Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 1/107 (0%)
Query: 113 HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAV-PL 171
H AQ ++ G L ++ L +P VKE AA+ L N ++ ++ GA+ L
Sbjct: 214 HQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKL 273
Query: 172 LVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMI 218
LV+ E + K+ AL + +H P + + G + L ++
Sbjct: 274 LVILATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLV 320
Score = 34.7 bits (78), Expect = 0.21
Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 1/106 (0%)
Query: 74 DLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVIC 133
D A+ ++ L ++ L K+ AAFVL A +P++ ++ GAL L++
Sbjct: 217 DNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVI 276
Query: 134 LEDFDP-GVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQE 178
L P K+ +AL + RH + + G + +L +QE
Sbjct: 277 LATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLVQE 322
Score = 30.4 bits (67), Expect = 4.0
Identities = 37/165 (22%), Positives = 69/165 (41%), Gaps = 4/165 (2%)
Query: 238 KHSVDLAEMVVEAEIFPVVLTCLK---DKDEYVKKNASTLIREIAKHTPELSQLVVNAGG 294
K D +V+E ++ +V K +K A+ E H + +Q +++ GG
Sbjct: 168 KKDFDELNVVIETDMQIMVRLINKFNSSSSSLEEKIAALFDLEYYVHQMDNAQDLLSFGG 227
Query: 295 VAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKA 354
+ VI+ + S + + +LG + + + + I + +L V L+ E K
Sbjct: 228 LQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVILATEQPLTAKK 287
Query: 355 AAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVK 399
+AL + RH P R L VL +L + + +E L V+
Sbjct: 288 KVLFALCSLLRHFPYAQRQFLKLGGLQVLRTL-VQEKGTEVLAVR 331
>gi|83641896 SIL1 protein precursor [Homo sapiens]
Length = 461
Score = 40.0 bits (92), Expect = 0.005
Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 1/107 (0%)
Query: 113 HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAV-PL 171
H AQ ++ G L ++ L +P VKE AA+ L N ++ ++ GA+ L
Sbjct: 214 HQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKL 273
Query: 172 LVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMI 218
LV+ E + K+ AL + +H P + + G + L ++
Sbjct: 274 LVILATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLV 320
Score = 34.7 bits (78), Expect = 0.21
Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 1/106 (0%)
Query: 74 DLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVIC 133
D A+ ++ L ++ L K+ AAFVL A +P++ ++ GAL L++
Sbjct: 217 DNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVI 276
Query: 134 LEDFDP-GVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQE 178
L P K+ +AL + RH + + G + +L +QE
Sbjct: 277 LATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLVQE 322
Score = 30.4 bits (67), Expect = 4.0
Identities = 37/165 (22%), Positives = 69/165 (41%), Gaps = 4/165 (2%)
Query: 238 KHSVDLAEMVVEAEIFPVVLTCLK---DKDEYVKKNASTLIREIAKHTPELSQLVVNAGG 294
K D +V+E ++ +V K +K A+ E H + +Q +++ GG
Sbjct: 168 KKDFDELNVVIETDMQIMVRLINKFNSSSSSLEEKIAALFDLEYYVHQMDNAQDLLSFGG 227
Query: 295 VAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKA 354
+ VI+ + S + + +LG + + + + I + +L V L+ E K
Sbjct: 228 LQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVILATEQPLTAKK 287
Query: 355 AAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVK 399
+AL + RH P R L VL +L + + +E L V+
Sbjct: 288 KVLFALCSLLRHFPYAQRQFLKLGGLQVLRTL-VQEKGTEVLAVR 331
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 39.7 bits (91), Expect = 0.007
Identities = 53/224 (23%), Positives = 96/224 (42%), Gaps = 10/224 (4%)
Query: 18 TQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTA-ALALGRLANYNDDLA 76
T Q V ++ P+ I + + ++S L D++ + TA L+ L+ + LA
Sbjct: 1046 TSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQELLA 1105
Query: 77 EAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVD-CGALDTLVICLE 135
+ L L L + +L + +HS L A+ G L L++ L
Sbjct: 1106 GSDESYRPLRSL---LGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLG 1162
Query: 136 DFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIA 195
D DP V+ +A++A+ A L A+ A AVP + + +P+ ++R ASAL ++
Sbjct: 1163 DKDPVVRCSASFAVGNAAYQAGPLGPAL--AAAVPSMTQLLGDPQAGIRRNVASALGNLG 1220
Query: 196 KHSPELAQTVVDAGAVAHLAQMIL-NPDAKLKHQILSALSQVSK 238
L + ++ L +M +P +K L AL + +
Sbjct: 1221 PEG--LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQ 1262
>gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens]
Length = 348
Score = 38.9 bits (89), Expect = 0.011
Identities = 60/266 (22%), Positives = 101/266 (37%), Gaps = 62/266 (23%)
Query: 15 KARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLD--------VVPTIQQTAALALG 66
+ R + + + +L P+ I N G M L+ LL D + TA+ ++G
Sbjct: 41 QTRQKALMALCDLMHDPECIYKAMNIGCMENLKALLKDSNSMVRIKTTEVLHITASHSVG 100
Query: 67 RLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGA 126
R A D+ A+ P V + YK V P+ AQ I+ G
Sbjct: 101 RYAFLEHDIVLALSFLLNDPSPVC----RGNLYKAYMQLV------QVPRGAQEIISKGL 150
Query: 127 LDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRI 186
+ +LV W L+ + E + ++D LVLC+QE
Sbjct: 151 ISSLV---------------WKLQ-VEVEEEEFQEFILDT-----LVLCLQED------- 182
Query: 187 AASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEM 246
A + + V L Q +L+ + ++ + AL VS S + +
Sbjct: 183 ---------------ATEALGSNVVLVLKQKLLSANQNIRSKAARALLNVSI-SREGKKQ 226
Query: 247 VVEAEIFPVVLTCLKDKDEYVKKNAS 272
V ++ P+++ LKD E+VK NA+
Sbjct: 227 VCHFDVIPILVHLLKDPVEHVKSNAA 252
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 38.1 bits (87), Expect = 0.019
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 1/105 (0%)
Query: 46 LRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAF 105
LR LL P + + A+ A+GRLA D V+ ++ L + A++N + AA
Sbjct: 111 LRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVL 170
Query: 106 VLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALR 150
VLR + P V D + + + D ++E A ALR
Sbjct: 171 VLRELAISVPTFFFQQVQ-PFFDNIFVAVWDPKQAIREGAVAALR 214
>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
Length = 607
Score = 37.7 bits (86), Expect = 0.025
Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)
Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
L + + + E +L+ L +A+++ E ++ + A + L +L P + K ++
Sbjct: 11 LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 69
Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
+ +++V+K+ + V+A + ++ L KD+ V + I + E V
Sbjct: 70 NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 128
Query: 291 NAGGVAAVIDCIGS 304
AGG VID + S
Sbjct: 129 QAGGAQIVIDHLRS 142
Score = 31.6 bits (70), Expect = 1.8
Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)
Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
LS + +HS ++ +T+V +G + HL M + ++++ L AL+ ++ + AE +
Sbjct: 470 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529
Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
E A++ ++ L D+ +K N+ LI
Sbjct: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLI 559
>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
Length = 607
Score = 37.7 bits (86), Expect = 0.025
Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)
Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
L + + + E +L+ L +A+++ E ++ + A + L +L P + K ++
Sbjct: 12 LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 70
Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
+ +++V+K+ + V+A + ++ L KD+ V + I + E V
Sbjct: 71 NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 129
Query: 291 NAGGVAAVIDCIGS 304
AGG VID + S
Sbjct: 130 QAGGAQIVIDHLRS 143
Score = 31.6 bits (70), Expect = 1.8
Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)
Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
LS + +HS ++ +T+V +G + HL M + ++++ L AL+ ++ + AE +
Sbjct: 470 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529
Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
E A++ ++ L D+ +K N+ LI
Sbjct: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLI 559
>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
[Homo sapiens]
Length = 608
Score = 37.7 bits (86), Expect = 0.025
Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)
Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
L + + + E +L+ L +A+++ E ++ + A + L +L P + K ++
Sbjct: 12 LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 70
Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
+ +++V+K+ + V+A + ++ L KD+ V + I + E V
Sbjct: 71 NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 129
Query: 291 NAGGVAAVIDCIGS 304
AGG VID + S
Sbjct: 130 QAGGAQIVIDHLRS 143
Score = 31.6 bits (70), Expect = 1.8
Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)
Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
LS + +HS ++ +T+V +G + HL M + ++++ L AL+ ++ + AE +
Sbjct: 471 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 530
Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
E A++ ++ L D+ +K N+ LI
Sbjct: 531 ESAKLVQILHRLLADERSAPEIKYNSMVLI 560
>gi|25092658 hypothetical protein LOC221927 [Homo sapiens]
Length = 821
Score = 37.7 bits (86), Expect = 0.025
Identities = 19/48 (39%), Positives = 33/48 (68%), Gaps = 6/48 (12%)
Query: 332 IISKGVPQLSVCLSEEPEDHIKAAAAWALGQI---GRH---TPEHARA 373
+++ VPQL++ L ++PE +++A+A A+GQ+ G H +PEHA A
Sbjct: 541 LLASEVPQLALQLLQDPESYVRASAVTAMGQLSSQGLHAPTSPEHAEA 588
Score = 29.6 bits (65), Expect = 6.8
Identities = 18/76 (23%), Positives = 40/76 (52%), Gaps = 6/76 (7%)
Query: 214 LAQMILNPDAKLKHQILSALSQVSKH---SVDLAEMVVEAEIFPVVLTCLKDKDEYVKKN 270
L + + +P +++ L L+Q+S+H D ++ +E+ + L L+D + YV+ +
Sbjct: 505 LQKRLCHPCWEVRDSALEFLTQLSRHWGGQADFRCALLASEVPQLALQLLQDPESYVRAS 564
Query: 271 ASTLIREIAK---HTP 283
A T + +++ H P
Sbjct: 565 AVTAMGQLSSQGLHAP 580
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 37.0 bits (84), Expect = 0.043
Identities = 26/149 (17%), Positives = 67/149 (44%), Gaps = 2/149 (1%)
Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
L + + + E +L+ L +A+++ E ++ + A + L +L P + K ++
Sbjct: 11 LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 69
Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
+ +++V+K+ + V+A + ++ L KD+ V + I + L ++
Sbjct: 70 NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLI 128
Query: 291 NAGGVAAVIDCIGSCKGNTRLPGIMMLGY 319
N G + ++ +G N L + ++ +
Sbjct: 129 NMGVIPTLVKLLGIHCQNAALTEMCLVAF 157
Score = 31.6 bits (70), Expect = 1.8
Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)
Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
LS + +HS ++ +T+V +G + HL M + ++++ L AL+ ++ + AE +
Sbjct: 421 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 480
Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
E A++ ++ L D+ +K N+ LI
Sbjct: 481 ESAKLVQILHRLLADERSAPEIKYNSMVLI 510
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 37.0 bits (84), Expect = 0.043
Identities = 26/149 (17%), Positives = 67/149 (44%), Gaps = 2/149 (1%)
Query: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230
L + + + E +L+ L +A+++ E ++ + A + L +L P + K ++
Sbjct: 12 LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 70
Query: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290
+ +++V+K+ + V+A + ++ L KD+ V + I + L ++
Sbjct: 71 NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLI 129
Query: 291 NAGGVAAVIDCIGSCKGNTRLPGIMMLGY 319
N G + ++ +G N L + ++ +
Sbjct: 130 NMGVIPTLVKLLGIHCQNAALTEMCLVAF 158
Score = 31.6 bits (70), Expect = 1.8
Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)
Query: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248
LS + +HS ++ +T+V +G + HL M + ++++ L AL+ ++ + AE +
Sbjct: 422 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 481
Query: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275
E A++ ++ L D+ +K N+ LI
Sbjct: 482 ESAKLVQILHRLLADERSAPEIKYNSMVLI 511
>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
Length = 493
Score = 37.0 bits (84), Expect = 0.043
Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 4/116 (3%)
Query: 113 HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLL 172
HS Q A A L+ L E + L + + + + ++ G VP L
Sbjct: 137 HSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPAL 196
Query: 173 VLCIQEPEIALKRIAASALSDI--AKHSPE-LAQTVVDAGAVAHLAQMILNPDAKL 225
CIQ P +A+ ALS + A+ +PE + +++ + H+ QM L P KL
Sbjct: 197 AACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQM-LQPGPKL 251
>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
isoform a [Homo sapiens]
Length = 949
Score = 36.6 bits (83), Expect = 0.056
Identities = 61/289 (21%), Positives = 115/289 (39%), Gaps = 31/289 (10%)
Query: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229
P +V C+Q + LK++ L + AK P++A V+ D + + +
Sbjct: 52 PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFV----------KDCEDPNPL 101
Query: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289
+ AL+ + + + + + E P+ CLKD+D YV+K A+ +AK +QLV
Sbjct: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQLV 156
Query: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPE 349
+ G + + D I + L +A + + + + + +L L+E E
Sbjct: 157 EDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTE 216
Query: 350 -----------DHIKAAAAWALGQIGRHTP--EHARAVAVTNTLPVLLSLYMSTESSEDL 396
+++ A R TP HA + V + + VL+ S+DL
Sbjct: 217 WGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML--SKDL 274
Query: 397 QVKSKKAIKNILQKCTYLPALEPFLYDAPPNILKHVVGQFSKVLPHDSK 445
+K + L + EP L + +V + ++L H+ K
Sbjct: 275 DYYG-TLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMK 322
Score = 32.3 bits (72), Expect = 1.0
Identities = 52/218 (23%), Positives = 95/218 (43%), Gaps = 50/218 (22%)
Query: 133 CLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALS 192
CL+D DP V++ AA + + NA+L V D G + L I + + A +ALS
Sbjct: 129 CLKDEDPYVRKTAAVCVAKLHDINAQL---VEDQGFLDTLKDLISDSNPMVVANAVAALS 185
Query: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
+IA+ P + ++D LNP + +++L+AL++ ++ +I
Sbjct: 186 EIAESHP--SSNLLD-----------LNPQS--INKLLTALNECTEW----------GQI 220
Query: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLP 312
F +L CL + + A ++ + TP LS N+ V + +
Sbjct: 221 F--ILDCLANYMPKDDREAQSICERV---TPRLSH--ANSAVVLSAVK------------ 261
Query: 313 GIMMLGYVAAHSENL-AMAVIISKGVPQLSVCLSEEPE 349
+++ ++ S++L ++ K P L LS EPE
Sbjct: 262 --VLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPE 297
>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
isoform b [Homo sapiens]
Length = 942
Score = 36.6 bits (83), Expect = 0.056
Identities = 61/289 (21%), Positives = 115/289 (39%), Gaps = 31/289 (10%)
Query: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229
P +V C+Q + LK++ L + AK P++A V+ D + + +
Sbjct: 52 PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFV----------KDCEDPNPL 101
Query: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289
+ AL+ + + + + + E P+ CLKD+D YV+K A+ +AK +QLV
Sbjct: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQLV 156
Query: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPE 349
+ G + + D I + L +A + + + + + +L L+E E
Sbjct: 157 EDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTE 216
Query: 350 -----------DHIKAAAAWALGQIGRHTP--EHARAVAVTNTLPVLLSLYMSTESSEDL 396
+++ A R TP HA + V + + VL+ S+DL
Sbjct: 217 WGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML--SKDL 274
Query: 397 QVKSKKAIKNILQKCTYLPALEPFLYDAPPNILKHVVGQFSKVLPHDSK 445
+K + L + EP L + +V + ++L H+ K
Sbjct: 275 DYYG-TLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMK 322
Score = 32.3 bits (72), Expect = 1.0
Identities = 52/218 (23%), Positives = 95/218 (43%), Gaps = 50/218 (22%)
Query: 133 CLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALS 192
CL+D DP V++ AA + + NA+L V D G + L I + + A +ALS
Sbjct: 129 CLKDEDPYVRKTAAVCVAKLHDINAQL---VEDQGFLDTLKDLISDSNPMVVANAVAALS 185
Query: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
+IA+ P + ++D LNP + +++L+AL++ ++ +I
Sbjct: 186 EIAESHP--SSNLLD-----------LNPQS--INKLLTALNECTEW----------GQI 220
Query: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLP 312
F +L CL + + A ++ + TP LS N+ V + +
Sbjct: 221 F--ILDCLANYMPKDDREAQSICERV---TPRLSH--ANSAVVLSAVK------------ 261
Query: 313 GIMMLGYVAAHSENL-AMAVIISKGVPQLSVCLSEEPE 349
+++ ++ S++L ++ K P L LS EPE
Sbjct: 262 --VLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPE 297
>gi|154090976 sterile alpha and TIR motif containing 1 [Homo
sapiens]
Length = 724
Score = 36.6 bits (83), Expect = 0.056
Identities = 45/187 (24%), Positives = 78/187 (41%), Gaps = 8/187 (4%)
Query: 39 NAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRF 98
+ G+ LLR L + T Q A L L N D + IL +LA++
Sbjct: 123 DGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVIL-----NLAKEREP 177
Query: 99 YK--KAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHN 156
+ ++ A +L + KHS + Q +V G LD ++ DP + A AL A H
Sbjct: 178 VELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHG 237
Query: 157 AE-LSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLA 215
+ + + +V+ A L E L R+ A + + E+ + V +G +A +
Sbjct: 238 GQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVE 297
Query: 216 QMILNPD 222
++ + D
Sbjct: 298 PLVASLD 304
Score = 30.4 bits (67), Expect = 4.0
Identities = 41/197 (20%), Positives = 80/197 (40%), Gaps = 8/197 (4%)
Query: 200 ELAQTVVDA----GAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPV 255
E+AQ + DA G + L +++ P+ + + Q L Q+ + + V + V
Sbjct: 111 EVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILV--AENRDRVARIGL-GV 167
Query: 256 VLTCLKDKDEY-VKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGI 314
+L K+++ + ++ + ++ + KH+ E Q +V AGG+ AV+
Sbjct: 168 ILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCA 227
Query: 315 MMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAV 374
+ LG A H ++ K + L+ ED + A + E R V
Sbjct: 228 LALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREV 287
Query: 375 AVTNTLPVLLSLYMSTE 391
+ TL ++ L S +
Sbjct: 288 ERSGTLALVEPLVASLD 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,289,344
Number of Sequences: 37866
Number of extensions: 681834
Number of successful extensions: 1973
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 1733
Number of HSP's gapped (non-prelim): 159
length of query: 509
length of database: 18,247,518
effective HSP length: 107
effective length of query: 402
effective length of database: 14,195,856
effective search space: 5706734112
effective search space used: 5706734112
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.