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Search of human proteins with 6912356
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912356 echinoderm microtubule associated protein like 2
[Homo sapiens]
(649 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912356 echinoderm microtubule associated protein like 2 [Hom... 1347 0.0
gi|56790932 echinoderm microtubule associated protein like 1 iso... 981 0.0
gi|56790930 echinoderm microtubule associated protein like 1 iso... 981 0.0
gi|223029510 echinoderm microtubule associated protein like 4 is... 818 0.0
gi|19923497 echinoderm microtubule associated protein like 4 iso... 818 0.0
gi|110227615 echinoderm microtubule associated protein like 3 [H... 722 0.0
gi|223005862 echinoderm microtubule associated protein like 6 [H... 405 e-113
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 389 e-108
gi|94400919 WD repeat domain 90 [Homo sapiens] 93 9e-19
gi|31377846 WD repeat domain 52 [Homo sapiens] 85 2e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens] 83 9e-16
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 70 8e-12
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 70 8e-12
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 70 8e-12
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 70 8e-12
gi|190684671 mitogen-activated protein kinase binding protein 1 ... 70 8e-12
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 69 1e-11
gi|32189425 WD repeat domain 69 [Homo sapiens] 67 4e-11
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 67 5e-11
gi|19913367 transducin beta-like 1Y [Homo sapiens] 66 1e-10
gi|19913365 transducin beta-like 1Y [Homo sapiens] 66 1e-10
gi|15150805 transducin beta-like 1Y [Homo sapiens] 66 1e-10
gi|190684677 mitogen-activated protein kinase binding protein 1 ... 65 1e-10
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens] 65 2e-10
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens] 65 2e-10
gi|22749037 WD repeat domain 65 [Homo sapiens] 64 6e-10
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 60 8e-09
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 60 8e-09
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 60 8e-09
gi|26665869 WD repeat domain 51B [Homo sapiens] 59 2e-08
>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
sapiens]
Length = 649
Score = 1347 bits (3487), Expect = 0.0
Identities = 649/649 (100%), Positives = 649/649 (100%)
Query: 1 MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWV 60
MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWV
Sbjct: 1 MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWV 60
Query: 61 YGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTI 120
YGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTI
Sbjct: 61 YGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTI 120
Query: 121 ATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVD 180
ATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVD
Sbjct: 121 ATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVD 180
Query: 181 ESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLS 240
ESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLS
Sbjct: 181 ESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLS 240
Query: 241 KRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGL 300
KRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGL
Sbjct: 241 KRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGL 300
Query: 301 CALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSI 360
CALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSI
Sbjct: 301 CALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSI 360
Query: 361 LQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDP 420
LQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDP
Sbjct: 361 LQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDP 420
Query: 421 ARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSH 480
ARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSH
Sbjct: 421 ARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSH 480
Query: 481 DNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQ 540
DNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQ
Sbjct: 481 DNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQ 540
Query: 541 ITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLF 600
ITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLF
Sbjct: 541 ITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLF 600
Query: 601 SYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV 649
SYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV
Sbjct: 601 SYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV 649
>gi|56790932 echinoderm microtubule associated protein like 1
isoform a [Homo sapiens]
Length = 834
Score = 981 bits (2537), Expect = 0.0
Identities = 440/642 (68%), Positives = 534/642 (83%)
Query: 8 KTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRD 67
K KE +FS E+G VKMFLRGRPV M +P + +YSL+ + ELP+ RLKLEWVYGYRGRD
Sbjct: 193 KPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRD 252
Query: 68 CRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAG 127
CR NLYLLPTGE VYF+ASV VLY+VEEQ QRHY GHNDD+KCLA+HPD +TIATGQVAG
Sbjct: 253 CRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAG 312
Query: 128 TTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHML 187
T+K+GK LPPHVRIWDSV+L+TLHV+G+G FDRAV C+ FSKSNGG LCAVD+SNDH+L
Sbjct: 313 TSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVL 372
Query: 188 SVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFE 247
SVWDW KE K+ DVKCSNEAV A FHPTD +++TCGKSH+YFWTLEG SL+K+QGLFE
Sbjct: 373 SVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFE 432
Query: 248 KHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGT 307
K EKPK+VLCVTF E GD +TGDS GN+ VWGKG NRI+ AV GAH+GG+F LC LRDGT
Sbjct: 433 KQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGT 492
Query: 308 LVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHT 367
LVSGGG+DR+++ W +Y KL++ E+PE FGP+RTVAEG GD + +GTTRN +LQG++
Sbjct: 493 LVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSG 552
Query: 368 GFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFH 427
F+ + QGH +ELWGLA H S++QF+TCG DK LW + H+P+W +IIEDPA+S+GFH
Sbjct: 553 DFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFH 612
Query: 428 PSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVY 487
PSGSV+AVGT+TGRW + DTET DLV +HTDGNEQ+SV+ +SPDG +LA+GSHDN +Y+Y
Sbjct: 613 PSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIY 672
Query: 488 TVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAV 547
V GRK +R+GKCSGHSSFITHLDW+ +S V+NSGDYEILYW P+ CKQ+ S +
Sbjct: 673 GVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETT 732
Query: 548 RNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQP 607
R++EWAT TC LGF VFG+W EG+DGTDINAV R+H+ KLL++ DDFGKVHLFSYPC Q
Sbjct: 733 RDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQF 792
Query: 608 RALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV 649
RA SH YGGHSSHVTNV FL +DS ++TGGKDTS++QWRV+
Sbjct: 793 RAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 834
>gi|56790930 echinoderm microtubule associated protein like 1
isoform b [Homo sapiens]
Length = 815
Score = 981 bits (2537), Expect = 0.0
Identities = 440/642 (68%), Positives = 534/642 (83%)
Query: 8 KTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRD 67
K KE +FS E+G VKMFLRGRPV M +P + +YSL+ + ELP+ RLKLEWVYGYRGRD
Sbjct: 174 KPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRD 233
Query: 68 CRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAG 127
CR NLYLLPTGE VYF+ASV VLY+VEEQ QRHY GHNDD+KCLA+HPD +TIATGQVAG
Sbjct: 234 CRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAG 293
Query: 128 TTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHML 187
T+K+GK LPPHVRIWDSV+L+TLHV+G+G FDRAV C+ FSKSNGG LCAVD+SNDH+L
Sbjct: 294 TSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVL 353
Query: 188 SVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFE 247
SVWDW KE K+ DVKCSNEAV A FHPTD +++TCGKSH+YFWTLEG SL+K+QGLFE
Sbjct: 354 SVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFE 413
Query: 248 KHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGT 307
K EKPK+VLCVTF E GD +TGDS GN+ VWGKG NRI+ AV GAH+GG+F LC LRDGT
Sbjct: 414 KQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGT 473
Query: 308 LVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHT 367
LVSGGG+DR+++ W +Y KL++ E+PE FGP+RTVAEG GD + +GTTRN +LQG++
Sbjct: 474 LVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSG 533
Query: 368 GFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFH 427
F+ + QGH +ELWGLA H S++QF+TCG DK LW + H+P+W +IIEDPA+S+GFH
Sbjct: 534 DFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFH 593
Query: 428 PSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVY 487
PSGSV+AVGT+TGRW + DTET DLV +HTDGNEQ+SV+ +SPDG +LA+GSHDN +Y+Y
Sbjct: 594 PSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIY 653
Query: 488 TVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAV 547
V GRK +R+GKCSGHSSFITHLDW+ +S V+NSGDYEILYW P+ CKQ+ S +
Sbjct: 654 GVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETT 713
Query: 548 RNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQP 607
R++EWAT TC LGF VFG+W EG+DGTDINAV R+H+ KLL++ DDFGKVHLFSYPC Q
Sbjct: 714 RDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQF 773
Query: 608 RALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV 649
RA SH YGGHSSHVTNV FL +DS ++TGGKDTS++QWRV+
Sbjct: 774 RAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 818 bits (2113), Expect = 0.0
Identities = 374/656 (57%), Positives = 495/656 (75%), Gaps = 14/656 (2%)
Query: 6 AGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRG 65
A K K+VI + E +KMF+RGRP+ M IP ++ Y D R+ELP +LKLEW YGYRG
Sbjct: 154 ADKHKDVIINQEGEYIKMFMRGRPITMFIPSDV-DNYD-DIRTELPPEKLKLEWAYGYRG 211
Query: 66 RDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQV 125
+DCRAN+YLLPTGEIVYF+ASV VL++ EE+ QRHYLGH D +KCLAIHPD + IATGQ+
Sbjct: 212 KDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQI 271
Query: 126 AGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDH 185
AG K+G+PL PHVR+WDSV+LSTL ++GLG F+R V C+ FSK++ G LC +D+SN+H
Sbjct: 272 AGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEH 331
Query: 186 MLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGL 245
ML+VWDW K+ K ++K +NE VL FHPTD +ITCGKSHI+FWT G SL+++QG+
Sbjct: 332 MLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGI 391
Query: 246 FEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVW---------GKGGNRITQ--AVLGAHD 294
F K+EKPK+V C+ FL GDV+TGDSGG + +W GKG + Q + AHD
Sbjct: 392 FGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHD 451
Query: 295 GGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVG 354
G VF LC +R+G L++GGG+DR+++LW D + +E+EVP+ +G +R VAEG D VG
Sbjct: 452 GSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVG 511
Query: 355 TTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWS 414
T+RN IL+G+ + GF + VQGH +ELWGLATHP + +TC QD+ V LW+S H+ W+
Sbjct: 512 TSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWT 571
Query: 415 RIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAY 474
R++++P A FHPSG+V+A+GT +GRW +LD ET DLV+IHTDGNEQ+SV+ +S DG +
Sbjct: 572 RLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTF 631
Query: 475 LAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWD 534
LAVGSHDN +Y+Y V + GRK SR G+C+GHSS+ITHLDW+ D+ ++NSGDYEILYWD
Sbjct: 632 LAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 691
Query: 535 -PATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADD 593
P CK I + ++++W T TCVLGF VFG+W EG+DGTDINA+ RSH+ K++A ADD
Sbjct: 692 IPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADD 751
Query: 594 FGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV 649
F KVHLF YPC + +A SHKY HSSHVTNV+F +DS ++TGGKD S++QW++V
Sbjct: 752 FCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLV 807
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 818 bits (2113), Expect = 0.0
Identities = 374/656 (57%), Positives = 495/656 (75%), Gaps = 14/656 (2%)
Query: 6 AGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRG 65
A K K+VI + E +KMF+RGRP+ M IP ++ Y D R+ELP +LKLEW YGYRG
Sbjct: 212 ADKHKDVIINQEGEYIKMFMRGRPITMFIPSDV-DNYD-DIRTELPPEKLKLEWAYGYRG 269
Query: 66 RDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQV 125
+DCRAN+YLLPTGEIVYF+ASV VL++ EE+ QRHYLGH D +KCLAIHPD + IATGQ+
Sbjct: 270 KDCRANVYLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQI 329
Query: 126 AGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDH 185
AG K+G+PL PHVR+WDSV+LSTL ++GLG F+R V C+ FSK++ G LC +D+SN+H
Sbjct: 330 AGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEH 389
Query: 186 MLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGL 245
ML+VWDW K+ K ++K +NE VL FHPTD +ITCGKSHI+FWT G SL+++QG+
Sbjct: 390 MLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGI 449
Query: 246 FEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVW---------GKGGNRITQ--AVLGAHD 294
F K+EKPK+V C+ FL GDV+TGDSGG + +W GKG + Q + AHD
Sbjct: 450 FGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHD 509
Query: 295 GGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVG 354
G VF LC +R+G L++GGG+DR+++LW D + +E+EVP+ +G +R VAEG D VG
Sbjct: 510 GSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVG 569
Query: 355 TTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWS 414
T+RN IL+G+ + GF + VQGH +ELWGLATHP + +TC QD+ V LW+S H+ W+
Sbjct: 570 TSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWT 629
Query: 415 RIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAY 474
R++++P A FHPSG+V+A+GT +GRW +LD ET DLV+IHTDGNEQ+SV+ +S DG +
Sbjct: 630 RLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTF 689
Query: 475 LAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWD 534
LAVGSHDN +Y+Y V + GRK SR G+C+GHSS+ITHLDW+ D+ ++NSGDYEILYWD
Sbjct: 690 LAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 749
Query: 535 -PATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADD 593
P CK I + ++++W T TCVLGF VFG+W EG+DGTDINA+ RSH+ K++A ADD
Sbjct: 750 IPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADD 809
Query: 594 FGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV 649
F KVHLF YPC + +A SHKY HSSHVTNV+F +DS ++TGGKD S++QW++V
Sbjct: 810 FCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLV 865
>gi|110227615 echinoderm microtubule associated protein like 3 [Homo
sapiens]
Length = 896
Score = 722 bits (1864), Expect = 0.0
Identities = 347/677 (51%), Positives = 469/677 (69%), Gaps = 30/677 (4%)
Query: 1 MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWV 60
+SS G ++ +++E SVKMFLRGRP+ M IP + L S P L L+WV
Sbjct: 196 LSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELP--SGPPPETLSLDWV 253
Query: 61 YGYRGRDCRANLYLLPTGEIVYFVASVAVLY-------SVEEQRQRHYLGHNDDIKCLAI 113
YGYRGRD R+NL++L +GE+VYF+A V VLY QRHY GH D ++CLA+
Sbjct: 254 YGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDCVRCLAV 313
Query: 114 HPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGG 173
HPD V +A+GQ AG K+GKPL P V IWDS +L L +GLG F+R V + FS ++ G
Sbjct: 314 HPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQG 373
Query: 174 NLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWT 233
LC VD+SN+HMLSVWD ++ K+ ++K +N++VL F+P D + ++T GKSH++FW
Sbjct: 374 AFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWN 433
Query: 234 LEGG-------SLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGK------ 280
GG +L+++QG+F K++KPK++ C FL GD++TGDS GN+ WG+
Sbjct: 434 WSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSPSDSK 493
Query: 281 ----GGNRITQAVLG---AHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEV 333
GG + T ++ AH+G +F LC RDGT++SGGGRDRR+V WG LQE E+
Sbjct: 494 TPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEI 553
Query: 334 PEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFV 393
PE FG VR +AEG G L VGTT+N++L+G + GFS ++QGH +ELWGL THPS+ +F+
Sbjct: 554 PEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFL 613
Query: 394 TCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLV 453
TCG D+ + LW +SH WS +++ A FHPSG+V+AVG TGRWL+LDTET ++V
Sbjct: 614 TCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIV 673
Query: 454 AIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLD 513
+ DGNEQ+SVV +SPDG YLA+GSHDN++Y+Y+V G K SR G+C GHSSFITHLD
Sbjct: 674 SDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLD 733
Query: 514 WAQDSSCFVTNSGDYEILYWDPA-TCKQITSADAVRNMEWATATCVLGFGVFGIWSEGAD 572
W++D + ++NSGDYEILYWD A CKQ+ + R+ EWAT TCVLGF V+G+W +G+D
Sbjct: 734 WSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVLGFHVYGVWPDGSD 793
Query: 573 GTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSM 632
GTDIN++ RSH+ +++A ADDF KVHLF YPC + +A S YGGH SHVT+V F DDS
Sbjct: 794 GTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFTHDDSH 853
Query: 633 ALTTGGKDTSVLQWRVV 649
++ GGKD S+ QWRV+
Sbjct: 854 LVSLGGKDASIFQWRVL 870
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 405 bits (1041), Expect = e-113
Identities = 235/607 (38%), Positives = 336/607 (55%), Gaps = 27/607 (4%)
Query: 51 PSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKC 110
P C+L+LEWVYGYRG CR NLY E+VYFVA V V+Y+ E Q+ +LGHNDDI
Sbjct: 7 PRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGHNDDIIS 66
Query: 111 LAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKS 170
LA+HPD +ATGQV KE P++ IWDS ++ T+ +L V V C+ F
Sbjct: 67 LALHPDKTLVATGQVG---KE-----PYICIWDSYNVQTVSLLK-DVHTHGVACLAFDSD 117
Query: 171 NGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIY 230
G L +V + + +WDW K + ++ + ++ P P +++CG HI
Sbjct: 118 --GQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIK 175
Query: 231 FWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVL 290
FWTL G +L+ ++G+F K + +LC+ + +G G++YVW KG N + + +
Sbjct: 176 FWTLCGNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW-KGLN-LVRTIQ 233
Query: 291 GAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFG-----PVRTVAE 345
GAH G+F + A +G + GGRD + LW +D+ + ++++ E +R+V
Sbjct: 234 GAHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVC- 290
Query: 346 GHGDTLYVGTTRNSILQGSVHTGFS--LLVQGHVE-ELWGLATHPSRAQFVTCGQDKLVH 402
D L GT + I + V L++QGH E ELW LA HP + VT D+ V
Sbjct: 291 WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVR 350
Query: 403 LWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQ 462
LWS H + +E+ RS F P GS LA+G G +++L V D E
Sbjct: 351 LWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEV 410
Query: 463 ISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFV 522
I + FSPDG+YLAVGS+D V VY V Q +K+ G+CS SFITH+DW+ DS
Sbjct: 411 IHEMKFSPDGSYLAVGSNDGPVDVYAVAQRYKKI---GECSKSLSFITHIDWSLDSKYLQ 467
Query: 523 TNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARS 582
TN G E L++ + K +TS + ++ + WA+ TCV G V GIW + + TDIN+V +
Sbjct: 468 TNDGAGERLFYRMPSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDAN 527
Query: 583 HDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTS 642
++ +L S DDFG V LF +PC + A KY GHS+HVTNV + D L+TGG D S
Sbjct: 528 YNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHS 587
Query: 643 VLQWRVV 649
V QWR +
Sbjct: 588 VFQWRFI 594
Score = 372 bits (955), Expect = e-103
Identities = 235/620 (37%), Positives = 330/620 (53%), Gaps = 42/620 (6%)
Query: 47 RSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHND 106
R + P LKL++++GYRG DCR NL+ GE+VY +A+VAV+Y+ ++ QR YLGH+D
Sbjct: 669 REKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDD 728
Query: 107 DIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVG 166
DI L IHP +ATGQV G+ HV WD+ +L L +L G R VC +
Sbjct: 729 DILSLTIHPVKDYVATGQV------GRDAAIHV--WDTQTLKCLSLLK-GQHQRGVCALD 779
Query: 167 FSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGK 226
FS G L +V + H + WDW K K+ + + + V +P L+T G
Sbjct: 780 FSAD--GKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGI 837
Query: 227 SHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVV-TGDSGGNLYVWGKGGNRI 285
HI FW GG + ++G F K + ++CV++ D+V +G + G++++W + +
Sbjct: 838 KHIKFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWK---DIL 894
Query: 286 TQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVE------------- 332
+ AHDG VF + AL G + GG+D V LW + + +
Sbjct: 895 LLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWDDMFERCLKTYAIKRSALSTSSKG 952
Query: 333 -VPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVE-ELWGLATHPSRA 390
+ ED +R + GHG L VGT IL+ +LLVQGH+E E+WGLA HP
Sbjct: 953 LLLEDNPSIRAITLGHGHIL-VGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLP 1011
Query: 391 QFVTCGQDKLVHLWS-SDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTET 449
T DK + +W S H+ L R ++ R F P G LAVG G +L+++ +T
Sbjct: 1012 ICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADT 1071
Query: 450 -HDLVAIHTDGNEQISVVSFSPD-GAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSS 507
D+V+ H E IS + FS D G YLAV SHDN V +Y V R+G C G SS
Sbjct: 1072 VEDMVSFH-HRKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTS----KRVGICKGASS 1126
Query: 508 FITHLDWAQDSSCFVTNSGDYEILYWD-PATCKQITSADAVRNMEWATATCVLGFGVFGI 566
+ITH+DW NSG E L+++ P + I + +EW T TCVLG GI
Sbjct: 1127 YITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGI 1186
Query: 567 WSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAF 626
W +D TD+NA + + D LLA+ DDFG V LFSYP A KY GHS+HVTNV +
Sbjct: 1187 WPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRW 1246
Query: 627 LWDDSMALTTGGKDTSVLQW 646
L +DS+ LT GG DT+++ W
Sbjct: 1247 LHNDSVLLTVGGADTALMIW 1266
Score = 320 bits (821), Expect = 2e-87
Identities = 201/609 (33%), Positives = 309/609 (50%), Gaps = 31/609 (5%)
Query: 55 LKLEWVYGYRGRDCRANLYLLPTG-EIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAI 113
L L+ V+GYRG DCR NL+ L G +I++ A+ ++ ++ Q YL H DDI CL +
Sbjct: 1363 LALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTV 1422
Query: 114 --HPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSN 171
HP + GTT P + IWD+++ TL +L + V + FS +
Sbjct: 1423 NQHPKYRNVVATSQIGTT-------PSIHIWDAMTKHTLSMLRC-FHSKGVNYINFSAT- 1473
Query: 172 GGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYF 231
G LL +V +H ++VW W + KV E + V F P T ++ G H+ F
Sbjct: 1474 -GKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKF 1532
Query: 232 WTLEGGSLSKRQGLFEK--HEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAV 289
WTL G +L ++G+ K + +L V F TG G++YVW + + + V
Sbjct: 1533 WTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWKD--HFLIRLV 1590
Query: 290 LGAHDGGVFGL-CALRDGTLVSGGGRDR------RVVLWGSDYSKLQ--EVEVPEDFGPV 340
AH G VF + LRDG +V+GG ++R V LW + + + ++E + V
Sbjct: 1591 AKAHTGPVFTMYTTLRDGLIVTGG-KERPTKEGGAVKLWDQEMKRCRAFQLETGQLVECV 1649
Query: 341 RTVAEGHGDTLYVGTTRNSILQ-GSVHTGFSLLVQGHVE-ELWGLATHPSRAQFVTCGQD 398
R+V G G L VGT I++ G + ++L+ GH+E E+WGLATHPS+ F++ D
Sbjct: 1650 RSVCRGKGKIL-VGTKDGEIIEVGEKNAASNILIDGHMEGEIWGLATHPSKDLFISASND 1708
Query: 399 KLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTD 458
+W + L + AR A + P G ++A+G G +++L + + D
Sbjct: 1709 GTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRD 1768
Query: 459 GNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDS 518
I + SPD +LAVGS ++ V Y + QG ++R+G C SF+ +D++ D
Sbjct: 1769 RKSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQG-TNLNRIGYCKDIPSFVIQMDFSADG 1827
Query: 519 SCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINA 578
++G Y+ + KQ+T A + + WA+ T VLG V GIW AD D+N
Sbjct: 1828 KYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNC 1887
Query: 579 VARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGG 638
+H G + + DDFG V LF +PC + A +Y GHS+HVTN+ F +DD ++TGG
Sbjct: 1888 ACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGG 1947
Query: 639 KDTSVLQWR 647
D SV WR
Sbjct: 1948 DDCSVFVWR 1956
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 389 bits (1000), Expect = e-108
Identities = 233/607 (38%), Positives = 336/607 (55%), Gaps = 27/607 (4%)
Query: 51 PSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKC 110
PSC L+LEWVYGYRG CR NLY EIVYFVA V V+YS E RQ+ Y GH+DDI
Sbjct: 7 PSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIIS 66
Query: 111 LAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKS 170
LA+HP+ V +ATGQV KE P++ IWDS ++ T+ VL V + C+ F
Sbjct: 67 LALHPERVLVATGQVG---KE-----PYICIWDSYTVQTISVLK-DVHTHGIACLAFDLD 117
Query: 171 NGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIY 230
G L +V + + + VWDW + + + + ++ P L++CG HI
Sbjct: 118 --GQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIK 175
Query: 231 FWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVL 290
FW+L G +L+ ++G+F K + +LC+ +G G++YVW KG N I + +
Sbjct: 176 FWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-KGINLI-RTIQ 233
Query: 291 GAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPE-DFG----PVRTVAE 345
GAH G+F + A +G + GGRD + LW + + +++ E D G VR+V
Sbjct: 234 GAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVC- 290
Query: 346 GHGDTLYVGTTRNSILQGSVHTGFS--LLVQGHVE-ELWGLATHPSRAQFVTCGQDKLVH 402
GD + VGT + I + V L++QGH E ELW LA HP++ VT D+ V
Sbjct: 291 WRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVR 350
Query: 403 LWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQ 462
+WS H + +E+P R A + G LA+G G + +L V D E
Sbjct: 351 IWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEA 410
Query: 463 ISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFV 522
I + +SPDG YLAVG +D+ V +Y V Q +KV G+C G SFITHLDW+ DS
Sbjct: 411 IHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKV---GECLGSLSFITHLDWSSDSRYLQ 467
Query: 523 TNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARS 582
TN G+ + L++ K++TS + ++ + WA+ TCV G V GIW + +D DIN+V +
Sbjct: 468 TNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGN 527
Query: 583 HDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTS 642
+ G++L +ADD+G + LF YPC + A KY GHS+HVTNV + D ++ GG D S
Sbjct: 528 YIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHS 587
Query: 643 VLQWRVV 649
V QW+ +
Sbjct: 588 VFQWKFI 594
Score = 344 bits (883), Expect = 1e-94
Identities = 224/620 (36%), Positives = 315/620 (50%), Gaps = 42/620 (6%)
Query: 47 RSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHND 106
R P ++L +V+GYRG DCR+NL+ GEIVY VA+V V+Y+ ++ QR YLGH+D
Sbjct: 669 RERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDD 728
Query: 107 DIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVG 166
DI CL IHP +ATGQV P + IWD+ ++ L +L G V V
Sbjct: 729 DILCLTIHPLKDYVATGQVG--------RDPSIHIWDTETIKPLSIL-KGHHQYGVSAVD 779
Query: 167 FSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGK 226
FS G L +V + H + +WDW K K+ + S + + V +P P LIT G
Sbjct: 780 FSAD--GKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGI 837
Query: 227 SHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVV-TGDSGGNLYVWGKGGNRI 285
H+ FW GG L R+G K ++C + ++ +G S G++ +W +
Sbjct: 838 KHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIW---RDIF 894
Query: 286 TQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVE------------- 332
+ AHDG VF + AL G + GG+D V LW + + +
Sbjct: 895 LVKTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWDDSFERCLKTYAIKRAALAPGSKG 952
Query: 333 -VPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVE-ELWGLATHPSRA 390
+ ED +R ++ GHG L VGT IL+ +LLVQGH+E E+WGLATHP
Sbjct: 953 LLLEDNPSIRAISLGHGHIL-VGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLP 1011
Query: 391 QFVTCGQDKLVHLWS-SDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTET 449
T DK + +W S SH L R ++ R F P G LAVG G +L+ + +T
Sbjct: 1012 ICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADT 1071
Query: 450 -HDLVAIHTDGNEQISVVSFSP-DGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSS 507
DLV+ H + IS + FSP G YLAV SHD+ + +Y V R+G C G +S
Sbjct: 1072 LEDLVSFH-HRKDMISDIRFSPGSGKYLAVASHDSFIDIYNV----MSSKRVGICKGATS 1126
Query: 508 FITHLDWAQDSSCFVTNSGDYEILYWD-PATCKQITSADAVRNMEWATATCVLGFGVFGI 566
+ITH+DW N+G E L+++ P KQ + V + WA+ T VLG GI
Sbjct: 1127 YITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGI 1186
Query: 567 WSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAF 626
W + TD+ A + D +LA+ DD G V LF YP +Y HS+HVTNV +
Sbjct: 1187 WPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRW 1246
Query: 627 LWDDSMALTTGGKDTSVLQW 646
+DDSM +T GG D S++ W
Sbjct: 1247 TYDDSMLVTLGGTDMSLMVW 1266
Score = 337 bits (864), Expect = 2e-92
Identities = 212/612 (34%), Positives = 320/612 (52%), Gaps = 26/612 (4%)
Query: 55 LKLEWVYGYRGRDCRANLYLLPTGE-IVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAI 113
L LE ++GYRGRDCR N++ L G+ I+Y ASV +L++V Q Y HNDDI CL +
Sbjct: 1371 LVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTV 1430
Query: 114 --HPDMVTI-ATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKS 170
HP + I ATGQV G + + P + IWD+++ TL +L + VC V FS +
Sbjct: 1431 NQHPKFINIVATGQV-GDSADMSATAPSIHIWDAMNKQTLSILRC-YHSKGVCSVSFSAT 1488
Query: 171 NGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIY 230
G LL +V +H +++W W + K+ N+ + VA F P T ++ G H+
Sbjct: 1489 --GKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVK 1546
Query: 231 FWTLEGGSLSKRQGLFEKHEKPKY--VLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQA 288
FWTL G +L ++GL E + +L + F TG G++ VW + + +
Sbjct: 1547 FWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKD--HILCRI 1604
Query: 289 VLGAHDGGVFGL-CALRDGTLVSGGGRDR------RVVLWGSDYSKLQ--EVEVPEDFGP 339
V AH+G VF + LRDG +V+GG ++R V LW + + + +E +
Sbjct: 1605 VARAHNGPVFAMYTTLRDGLIVTGG-KERPSKEGGAVKLWDQELRRCRAFRLETGQATDC 1663
Query: 340 VRTVAEGHGDTLYVGTTRNSILQ-GSVHTGFSLLVQGHVE-ELWGLATHPSRAQFVTCGQ 397
VR+V G G L VGT I++ G + ++LV GHV+ +WGLATHPSR F++ +
Sbjct: 1664 VRSVCRGKGKIL-VGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAE 1722
Query: 398 DKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHT 457
D V LW + L + AR+ + P G ++A+G G +++L + +
Sbjct: 1723 DGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKR 1782
Query: 458 DGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQD 517
D I + FSPD YLAVGS +N V Y + G ++R+ C SF+ +D++ D
Sbjct: 1783 DRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPT-LNRISYCKDIPSFVIQMDFSAD 1841
Query: 518 SSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDIN 577
SS +SG Y+ ++ + K + A+ + WAT T +LG V GIWS A+ D+N
Sbjct: 1842 SSYLQVSSGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVN 1901
Query: 578 AVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTG 637
SH G L + DDFG V LF +PC + A ++ GHS HVTN+ F D ++ G
Sbjct: 1902 CACVSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAG 1961
Query: 638 GKDTSVLQWRVV 649
G D S+ W+ V
Sbjct: 1962 GDDCSLFVWKCV 1973
>gi|94400919 WD repeat domain 90 [Homo sapiens]
Length = 1748
Score = 92.8 bits (229), Expect = 9e-19
Identities = 107/465 (23%), Positives = 176/465 (37%), Gaps = 58/465 (12%)
Query: 50 LPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIK 109
LP L+L+ V G+ G R L+ +VY +V V+ V+ QR +LGH D +
Sbjct: 354 LPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVS 413
Query: 110 CLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSK 169
LA+ +A+ Q P +R+WD + L + + VC + FS
Sbjct: 414 ALALDGSSSLLASAQARA--------PSVMRLWDFQTGRCLCLFRSPM--HVVCSLSFSD 463
Query: 170 SNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPT-----------DP 218
S G LLC V + + V W V E V++A H D
Sbjct: 464 S--GALLCGVGKDHHGRTMVVAWG----TGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDE 517
Query: 219 TVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVW 278
T + +CG+ + W L GG L +H ++ + F + D S L+V
Sbjct: 518 TRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFT-DLAFKQARDGCPEPSAAMLFVC 576
Query: 279 GKGGNRI-----------------TQAVLGAH-------DGGVFGLCALR-DGTLVSGGG 313
+ G+ + T+ G H G + +L + + G
Sbjct: 577 SRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGS 636
Query: 314 RDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSIL--QGSVHTGFSL 371
D + LW D+S + + E GPV +V + T + L ++ + +
Sbjct: 637 EDGFLRLWPLDFSSV--LLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHM 694
Query: 372 LVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWS-RIIEDPARSAGFHPSG 430
L + H + LA R Q T QD+ V +W + Q L+ ED + FHP+
Sbjct: 695 LARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTR 754
Query: 431 SVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYL 475
G +G E +++ HT ++ ++ +PDG L
Sbjct: 755 PTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLL 799
Score = 76.6 bits (187), Expect = 6e-14
Identities = 113/461 (24%), Positives = 179/461 (38%), Gaps = 46/461 (9%)
Query: 55 LKLEWVYGYRGRDCRANLYLLP-TGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAI 113
L+L+ V GY G RAN+ P TG Y + V+ + Q+H+ GH+ +I LA+
Sbjct: 1108 LRLKAVVGYSGNG-RANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLAL 1166
Query: 114 -HPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNG 172
H V + + TT + +R+WD H+ +F + + + S
Sbjct: 1167 SHSAQVLASASGRSSTTAHCQ-----IRVWDVSGGLCQHL----IFPHSTTVLALAFSPD 1217
Query: 173 GNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFW 232
LL + + + L++W A V + E V F+P D L G+ + FW
Sbjct: 1218 DRLLVTLGDHDGRTLALWGTATYDLVSSTRLP-EPVHGVAFNPWDAGELTCVGQGTVTFW 1276
Query: 233 TLE--GGSLSKRQGLFEKHEKPKYVLC--VTFLEGGD---VVTGDSGGNLYVWGKGGNRI 285
L+ G +S + + P+ V +T L G + G S G + VW R
Sbjct: 1277 LLQQRGADISLQ---VRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRC 1333
Query: 286 TQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLW-----------GSDYSKL-QEVEV 333
+ A DGG+ GL LVSG R+ LW GS S + E E+
Sbjct: 1334 FLS-WEADDGGI-GLLLFSGSRLVSGSSTG-RLRLWAVGAVSELRCKGSGASSVFMEHEL 1390
Query: 334 PEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSL-LVQGHVEELWGLATHPSRAQF 392
D V + D VGTT ++ S G S L+ GH ++ + P +
Sbjct: 1391 VLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHC 1450
Query: 393 VTCGQDKLVHLWSSDSHQ-PLWSRIIEDPARSAGF------HPSGSVLAVGTVTGRWLLL 445
TC +D V +W+ S + + +++ + P LA G G +
Sbjct: 1451 ATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIF 1510
Query: 446 DTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYV 486
+ ++ V+FS DG + G D LV V
Sbjct: 1511 SVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV 1551
>gi|31377846 WD repeat domain 52 [Homo sapiens]
Length = 982
Score = 84.7 bits (208), Expect = 2e-16
Identities = 125/543 (23%), Positives = 213/543 (39%), Gaps = 99/543 (18%)
Query: 37 ELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCR--ANLYLLPTGEIVYFVASVAVLYSVE 94
ELA + S +P L L +GY DCR ANL LL +Y + + +++
Sbjct: 115 ELASMPFVTLDSNIPLDLLTLVHSFGY---DCRKRANLQLLDDSIAIYIAGNQLIFLNLK 171
Query: 95 EQRQRHYLGHNDD-IKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVL 153
+ Q + + + I + +HP + K P + I++ SL VL
Sbjct: 172 TKEQIYLRSSSGEGIGVIGVHPHKTYFTVAE--------KGSFPDIIIYEYPSLRPYRVL 223
Query: 154 GLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATF 213
G ++ V F+ S GNLL +V + D+ L++W+W +E ++ K ++ V TF
Sbjct: 224 RDGT-EKGYAYVDFNYS--GNLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTF 280
Query: 214 HPTDPTVLITCGKSHIYFW----TLEGGSLSKRQGLFEKHEKPKYVLCVTFLEG------ 263
+P L T G HI FW T G L G F K T +EG
Sbjct: 281 NPDKEEQLTTSGSGHIKFWEMAFTFTGLKLQGSLGRFGK-------TITTDIEGYMELPD 333
Query: 264 GDVVTGDSGGNLYVWGKGGNRITQAVLG----AHDGGVFGLCALRDGTLVSGGGRDRRVV 319
G V++G GN+ +W +GG + G H+G + L +G +++ G D V
Sbjct: 334 GKVLSGSEWGNMLLW-EGGLIKVELCRGTSKSCHNGPI-NQIMLYEGEVITVGS-DGYVR 390
Query: 320 LWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEE 379
+W D+ + +V ++ G L + + +V+ FS++
Sbjct: 391 IW--DFETIDTADVIDETG-----------LLEIEPINELQVDKNVNL-FSMIKMNETGN 436
Query: 380 LWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVT 439
+ LA QD +W D +S I +DP FH SG++ AV
Sbjct: 437 NFWLA------------QDANGAIWKLDLS---FSNITQDPECLFSFH-SGAIEAVAVSP 480
Query: 440 GRWLLLDTETHDLVAIHTDGNE-QISVVSFSP--------------DGAYLAVGSHDNLV 484
+L+ T V I+ ++ ++ + F GA + VG D +V
Sbjct: 481 LTYLMATTALDCSVRIYDFASKTPLAQMKFKQGGTALVWVPRMVNFTGAQIIVGFEDGVV 540
Query: 485 YV--------YTVDQGGRK-----VSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEIL 531
+ T+ G +K + H++ +T L + +D T S D +
Sbjct: 541 RILELYDPKGLTIFAGRKKILDADIQLKQVFKPHTACVTALAYERDGEILATGSKDQTVF 600
Query: 532 YWD 534
+++
Sbjct: 601 FFE 603
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 82.8 bits (203), Expect = 9e-16
Identities = 69/265 (26%), Positives = 112/265 (42%), Gaps = 41/265 (15%)
Query: 305 DGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPV--------------RTVAE----- 345
D +L++GG D V +W KL+ V+ D + +T +E
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 540
Query: 346 GHGDTLYVGT---TRNSILQGSVH--------TGFSLLV--QGHVEELWGLATHPSRAQF 392
GH +Y + RN +L S F+ LV +GH +W P F
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600
Query: 393 VTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAG---FHPSGSVLAVGTVTGRWLLLDTET 449
V+ G D++ LW++D +QPL RI FHP+ + +A G+ L D
Sbjct: 601 VSGGHDRVARLWATDHYQPL--RIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 450 HDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFI 509
+ V I T I ++FSP+G +LA G+ D V ++ + G +G+ GH+ +
Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG----LMVGELKGHTDTV 714
Query: 510 THLDWAQDSSCFVTNSGDYEILYWD 534
L +++D + S D + WD
Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLWD 739
Score = 45.1 bits (105), Expect = 2e-04
Identities = 64/252 (25%), Positives = 96/252 (38%), Gaps = 41/252 (16%)
Query: 103 GHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVL------GLG 156
GH+ + + PD + + GT VR+W SL T L
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGT----------VRLW---SLQTFTCLVGYKGHNYP 587
Query: 157 VFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPT 216
V+D G+ +GG+ A + DH + +A + DV C+ FHP
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGH--LADVNCTR-------FHPN 638
Query: 217 DPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGD-VVTGDSGGNL 275
V + W + G+ + +F H+ P + L TF G + TG + G +
Sbjct: 639 SNYVATGSADRTVRLWDVLNGNCVR---IFTGHKGPIHSL--TFSPNGRFLATGATDGRV 693
Query: 276 YVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPE 335
+W G + + G H V L RDG +++ G D V LW D K E +
Sbjct: 694 LLWDIGHGLMVGELKG-HTDTVCSLRFSRDGEILASGSMDNTVRLW--DAIKAFEDLETD 750
Query: 336 DFGPVRTVAEGH 347
DF T A GH
Sbjct: 751 DF----TTATGH 758
Score = 32.0 bits (71), Expect = 1.8
Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 15/67 (22%)
Query: 82 YFVAS----VAVLYSVEE-QRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLP 136
YFV+ VA L++ + Q R + GH D+ C HP+ +ATG T
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT-------- 650
Query: 137 PHVRIWD 143
VR+WD
Sbjct: 651 --VRLWD 655
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 69.7 bits (169), Expect = 8e-12
Identities = 77/320 (24%), Positives = 125/320 (39%), Gaps = 28/320 (8%)
Query: 196 TKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLE----GGS--LSKRQGLFEK- 248
+K ++ V + ++P + G S W L GGS L R + E
Sbjct: 172 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 231
Query: 249 HEKP--KYVLCVTFLEGGDVV-TGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRD 305
H+ P K V + + G ++ TG G +W + GN + LG H G +F L R
Sbjct: 232 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN--LASTLGQHKGPIFALKWNRK 289
Query: 306 GTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSV 365
G + G D+ ++W + + ++ + P P V + +T + + + +
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDV-DWQNNTTFASCSTDMCIH-VC 346
Query: 366 HTGFSLLV---QGHVEELWGLATHPSRAQFVTCGQDKLVHLWSS---------DSHQPLW 413
G V QGH E+ + PS +C D + +WS +H
Sbjct: 347 RLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI 406
Query: 414 SRIIEDPARSAGFHPSGSV-LAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDG 472
I P A +P+ ++ LA + L D E T E + V+FSPDG
Sbjct: 407 YTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDG 466
Query: 473 AYLAVGSHDNLVYVYTVDQG 492
YLA GS D V+++ G
Sbjct: 467 KYLASGSFDKCVHIWNTQSG 486
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/146 (20%), Positives = 59/146 (40%), Gaps = 15/146 (10%)
Query: 182 SNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDP-------TVLITCGK--SHIYFW 232
S+D L +W +E + D++ N+ + + PT P +++ S + W
Sbjct: 380 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439
Query: 233 TLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGA 292
+E G + KH++P Y + + +G + +G +++W + + G
Sbjct: 440 DIERGVCTH---TLTKHQEPVYSVAFS-PDGKYLASGSFDKCVHIWNTQSGNLVHSYRGT 495
Query: 293 HDGGVFGLCALRDGTLVSGGGRDRRV 318
GG+F +C G V D V
Sbjct: 496 --GGIFEVCWNARGDKVGASASDGSV 519
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 69.7 bits (169), Expect = 8e-12
Identities = 77/320 (24%), Positives = 125/320 (39%), Gaps = 28/320 (8%)
Query: 196 TKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLE----GGS--LSKRQGLFEK- 248
+K ++ V + ++P + G S W L GGS L R + E
Sbjct: 172 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 231
Query: 249 HEKP--KYVLCVTFLEGGDVV-TGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRD 305
H+ P K V + + G ++ TG G +W + GN + LG H G +F L R
Sbjct: 232 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN--LASTLGQHKGPIFALKWNRK 289
Query: 306 GTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSV 365
G + G D+ ++W + + ++ + P P V + +T + + + +
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDV-DWQNNTTFASCSTDMCIH-VC 346
Query: 366 HTGFSLLV---QGHVEELWGLATHPSRAQFVTCGQDKLVHLWSS---------DSHQPLW 413
G V QGH E+ + PS +C D + +WS +H
Sbjct: 347 RLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI 406
Query: 414 SRIIEDPARSAGFHPSGSV-LAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDG 472
I P A +P+ ++ LA + L D E T E + V+FSPDG
Sbjct: 407 YTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDG 466
Query: 473 AYLAVGSHDNLVYVYTVDQG 492
YLA GS D V+++ G
Sbjct: 467 KYLASGSFDKCVHIWNTQSG 486
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/146 (20%), Positives = 59/146 (40%), Gaps = 15/146 (10%)
Query: 182 SNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDP-------TVLITCGK--SHIYFW 232
S+D L +W +E + D++ N+ + + PT P +++ S + W
Sbjct: 380 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439
Query: 233 TLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGA 292
+E G + KH++P Y + + +G + +G +++W + + G
Sbjct: 440 DIERGVCTH---TLTKHQEPVYSVAFS-PDGKYLASGSFDKCVHIWNTQSGNLVHSYRGT 495
Query: 293 HDGGVFGLCALRDGTLVSGGGRDRRV 318
GG+F +C G V D V
Sbjct: 496 --GGIFEVCWNARGDKVGASASDGSV 519
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 69.7 bits (169), Expect = 8e-12
Identities = 77/320 (24%), Positives = 125/320 (39%), Gaps = 28/320 (8%)
Query: 196 TKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLE----GGS--LSKRQGLFEK- 248
+K ++ V + ++P + G S W L GGS L R + E
Sbjct: 223 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
Query: 249 HEKP--KYVLCVTFLEGGDVV-TGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRD 305
H+ P K V + + G ++ TG G +W + GN + LG H G +F L R
Sbjct: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN--LASTLGQHKGPIFALKWNRK 340
Query: 306 GTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSV 365
G + G D+ ++W + + ++ + P P V + +T + + + +
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDV-DWQNNTTFASCSTDMCIH-VC 397
Query: 366 HTGFSLLV---QGHVEELWGLATHPSRAQFVTCGQDKLVHLWSS---------DSHQPLW 413
G V QGH E+ + PS +C D + +WS +H
Sbjct: 398 RLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI 457
Query: 414 SRIIEDPARSAGFHPSGSV-LAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDG 472
I P A +P+ ++ LA + L D E T E + V+FSPDG
Sbjct: 458 YTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDG 517
Query: 473 AYLAVGSHDNLVYVYTVDQG 492
YLA GS D V+++ G
Sbjct: 518 KYLASGSFDKCVHIWNTQSG 537
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/146 (20%), Positives = 59/146 (40%), Gaps = 15/146 (10%)
Query: 182 SNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDP-------TVLITCGK--SHIYFW 232
S+D L +W +E + D++ N+ + + PT P +++ S + W
Sbjct: 431 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490
Query: 233 TLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGA 292
+E G + KH++P Y + + +G + +G +++W + + G
Sbjct: 491 DIERGVCTH---TLTKHQEPVYSVAFS-PDGKYLASGSFDKCVHIWNTQSGNLVHSYRGT 546
Query: 293 HDGGVFGLCALRDGTLVSGGGRDRRV 318
GG+F +C G V D V
Sbjct: 547 --GGIFEVCWNARGDKVGASASDGSV 570
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 69.7 bits (169), Expect = 8e-12
Identities = 77/320 (24%), Positives = 125/320 (39%), Gaps = 28/320 (8%)
Query: 196 TKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLE----GGS--LSKRQGLFEK- 248
+K ++ V + ++P + G S W L GGS L R + E
Sbjct: 223 SKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
Query: 249 HEKP--KYVLCVTFLEGGDVV-TGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRD 305
H+ P K V + + G ++ TG G +W + GN + LG H G +F L R
Sbjct: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGN--LASTLGQHKGPIFALKWNRK 340
Query: 306 GTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSV 365
G + G D+ ++W + + ++ + P P V + +T + + + +
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDV-DWQNNTTFASCSTDMCIH-VC 397
Query: 366 HTGFSLLV---QGHVEELWGLATHPSRAQFVTCGQDKLVHLWSS---------DSHQPLW 413
G V QGH E+ + PS +C D + +WS +H
Sbjct: 398 RLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEI 457
Query: 414 SRIIEDPARSAGFHPSGSV-LAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDG 472
I P A +P+ ++ LA + L D E T E + V+FSPDG
Sbjct: 458 YTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDG 517
Query: 473 AYLAVGSHDNLVYVYTVDQG 492
YLA GS D V+++ G
Sbjct: 518 KYLASGSFDKCVHIWNTQSG 537
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/146 (20%), Positives = 59/146 (40%), Gaps = 15/146 (10%)
Query: 182 SNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDP-------TVLITCGK--SHIYFW 232
S+D L +W +E + D++ N+ + + PT P +++ S + W
Sbjct: 431 SDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490
Query: 233 TLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGA 292
+E G + KH++P Y + + +G + +G +++W + + G
Sbjct: 491 DIERGVCTH---TLTKHQEPVYSVAFS-PDGKYLASGSFDKCVHIWNTQSGNLVHSYRGT 546
Query: 293 HDGGVFGLCALRDGTLVSGGGRDRRV 318
GG+F +C G V D V
Sbjct: 547 --GGIFEVCWNARGDKVGASASDGSV 570
>gi|190684671 mitogen-activated protein kinase binding protein 1
isoform a [Homo sapiens]
Length = 1508
Score = 69.7 bits (169), Expect = 8e-12
Identities = 117/519 (22%), Positives = 185/519 (35%), Gaps = 104/519 (20%)
Query: 60 VYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHN-DDIKCLAIHPDMV 118
V G RG C +G + Y V VL++ + +Q H L + I LA PD
Sbjct: 49 VSGGRGLACDPR-----SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
Query: 119 TIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCA 178
+ TG+ P VR+WD S V L V CV FS S + +
Sbjct: 104 YLVTGESGHM--------PAVRVWDVAEHS--QVAELQEHKYGVACVAFSPS--AKYIVS 151
Query: 179 VDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGS 238
V +D +++VW W K V K S+ V+ D + +T G HI FW L+
Sbjct: 152 VGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVS--FSEDCSYFVTAGNRHIKFWYLDDSK 209
Query: 239 LSK-----------------RQGLFE-----KHEKPKYVLCVTFLEGGDVVTGDSGGNLY 276
SK R LF + +K C+T G + L
Sbjct: 210 TSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCIT--SSGLLCEFSDRRLLD 267
Query: 277 VWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRD-------RRVVLWGSDYSKLQ 329
W + + + + D + C DGT+ + R G+D + +
Sbjct: 268 KWVELRTTVAHCISVSQD---YIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVT 324
Query: 330 EVE--------------VPEDFGP----VRTVAEGHGDTLYVGTTRNSILQGSVHTGFSL 371
E + F P + V H ++YV R+ G V++
Sbjct: 325 EASRLFSGVANARYPDTIALTFDPTNQWLSCVYNDH--SIYVWDVRDPKKVGKVYSALY- 381
Query: 372 LVQGHVEELWGLATHPS----------RAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPA 421
H +W + +P + F+TC D + LW+++S S + +
Sbjct: 382 ----HSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNIL 437
Query: 422 RSAGFHPSGSVLAVGTVTGR-WLLLDTET---HDLVAIHTDGNEQISVVSFSPDGAYLAV 477
S ++ + V G LLDTE A D I V SP+G +LA
Sbjct: 438 -------SSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLAS 490
Query: 478 GSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQ 516
G + V+ + + +S + K H S I L++++
Sbjct: 491 GDRMGTLRVHEL----QSLSEMLKVEAHDSEILCLEYSK 525
Score = 31.6 bits (70), Expect = 2.4
Identities = 17/68 (25%), Positives = 28/68 (41%), Gaps = 4/68 (5%)
Query: 466 VSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNS 525
V P G Y+A D + ++ G + GHS +T + ++ D ++ S
Sbjct: 661 VQTDPSGIYIATSCSDKNLSIFDFSSG----ECVATMFGHSEIVTGMKFSNDCKHLISVS 716
Query: 526 GDYEILYW 533
GD I W
Sbjct: 717 GDSCIFVW 724
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 69.3 bits (168), Expect = 1e-11
Identities = 72/317 (22%), Positives = 118/317 (37%), Gaps = 24/317 (7%)
Query: 197 KVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKH------- 249
K V ++ V + ++P + G S W L S S L +H
Sbjct: 161 KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQ 220
Query: 250 --EKPKYVLCVTF-LEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDG 306
K V + + EG + TG G +W K GN + LG H G +F L + G
Sbjct: 221 DVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGN--LASTLGQHKGPIFALKWNKKG 278
Query: 307 TLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVH 366
+ G D+ ++W + + ++ + P P V +T +T I +
Sbjct: 279 NFILSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLG 337
Query: 367 TGFSLLV-QGHVEELWGLATHPSRAQFVTCGQDKLVHLWSS---------DSHQPLWSRI 416
+ QGH E+ + P+ +C D + +WS +H I
Sbjct: 338 QDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTI 397
Query: 417 IEDPARSAGFHPSGSV-LAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYL 475
P +P+ ++ LA + L D + + T E + V+FSPDG YL
Sbjct: 398 KWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYL 457
Query: 476 AVGSHDNLVYVYTVDQG 492
A GS D V+++ G
Sbjct: 458 ASGSFDKCVHIWNTQTG 474
Score = 37.7 bits (86), Expect = 0.033
Identities = 33/155 (21%), Positives = 63/155 (40%), Gaps = 17/155 (10%)
Query: 173 GNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDP-------TVLITCG 225
GNLL + S+D L +W ++ V D++ N+ + + PT P +++
Sbjct: 361 GNLLASC--SDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASA 418
Query: 226 K--SHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGN 283
S + W ++ G KH++P Y + + +G + +G +++W
Sbjct: 419 SFDSTVRLWDVDRGICIH---TLTKHQEPVYSVAFS-PDGRYLASGSFDKCVHIWNTQTG 474
Query: 284 RITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRV 318
+ + G GG+F +C G V D V
Sbjct: 475 ALVHSYRGT--GGIFEVCWNAAGDKVGASASDGSV 507
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 67.4 bits (163), Expect = 4e-11
Identities = 83/342 (24%), Positives = 130/342 (38%), Gaps = 40/342 (11%)
Query: 331 VEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLV-QGHVEELWGLATHPSR 389
VE + P+ T + L + + + Q S HT + V + H+ L +A + S
Sbjct: 45 VEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSG 104
Query: 390 AQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPAR----SAGFHPSGSVLAVGTVTGRWLLL 445
+ F+T D+ LW + S + L +E A +P G +A G+ L
Sbjct: 105 SCFITGSYDRTCKLWDTASGEEL--NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162
Query: 446 DTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGH 505
ET +I +SF+P +A GS D ++ + Q G +V L GH
Sbjct: 163 SVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI-QNGEEVYTL---RGH 218
Query: 506 SSFITHLDWAQDSSCFVTNSGDYEILYWDPAT----------CKQITSADAVRNMEWATA 555
S+ I L + +T S D+ ++ WD T C +I+SA + W +
Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA----SFNWDCS 274
Query: 556 ---------TCVLGFGVFGIWSEGADGTDINAVARSHD--GKLLASADDFGKVHLFSYPC 604
TC L G G D + D GKL+A+A G +FS
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS--- 331
Query: 605 CQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQW 646
R K GH ++ ++F L TG D + W
Sbjct: 332 AATRKCIAKLEGHEGEISKISFN-PQGNHLLTGSSDKTARIW 372
Score = 53.1 bits (126), Expect = 8e-07
Identities = 59/291 (20%), Positives = 104/291 (35%), Gaps = 11/291 (3%)
Query: 247 EKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDG 306
E H Y + G + TG +W + G H + L
Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRG-HTAEIVCLSFNPQS 189
Query: 307 TLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGP--VRTVAEGHGDTLYVGTTRNSILQGS 364
TLV+ G D LW D +EV + GD + G+ ++++
Sbjct: 190 TLVATGSMDTTAKLW--DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 365 VHTGFSL-LVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRI-IEDPAR 422
TG + ++ GH E+ + + + +T DK LW + + + + + +D
Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
Query: 423 SAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDN 482
+ F +G ++A + G + T +A +IS +SF+P G +L GS D
Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367
Query: 483 LVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYW 533
++ G L GH+ I + + +T S D W
Sbjct: 368 TARIWDAQTG----QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 44.3 bits (103), Expect = 4e-04
Identities = 42/173 (24%), Positives = 75/173 (43%), Gaps = 9/173 (5%)
Query: 373 VQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPAR--SAGFHPSG 430
++GH E+ L+ + S + +T D V +W +D+ + + + +I A SA F+
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-NILIGHCAEISSASFNWDC 273
Query: 431 SVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVD 490
S++ G++ L D VA T +++I F G +A S D +++
Sbjct: 274 SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA- 332
Query: 491 QGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPAT--CKQI 541
RK + K GH I+ + + + +T S D WD T C Q+
Sbjct: 333 -ATRKC--IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382
Score = 39.7 bits (91), Expect = 0.009
Identities = 55/265 (20%), Positives = 99/265 (37%), Gaps = 36/265 (13%)
Query: 90 LYSVEEQRQRH-YLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLS 148
L+SVE + H + GH +I CL+ +P +ATG + T K +WD +
Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK----------LWDIQNGE 210
Query: 149 TLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAV 208
++ L + + S + G+ + + S DH + VWD A + V++ + A
Sbjct: 211 EVYTLR----GHSAEIISLSFNTSGDRI--ITGSFDHTVVVWD-ADTGRKVNILIGHCAE 263
Query: 209 LVATFHPTDPTVLITCGKSH-IYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVV 267
+ + D ++++T W G K H+ C + G +
Sbjct: 264 ISSASFNWDCSLILTGSMDKTCKLWDATNG---KCVATLTGHDDEILDSCFDY-TGKLIA 319
Query: 268 TGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSK 327
T + G ++ R A L H+G + + G + G D+ +W +
Sbjct: 320 TASADGTARIF-SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA---- 374
Query: 328 LQEVEVPEDFGPVRTVAEGHGDTLY 352
G V EGH D ++
Sbjct: 375 --------QTGQCLQVLEGHTDEIF 391
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 67.0 bits (162), Expect = 5e-11
Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 7/167 (4%)
Query: 370 SLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPL--WSRIIEDPARSAGFH 427
++L QGH +W L P F + D+ LWS D PL ++ + D FH
Sbjct: 377 TVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD-VDCVKFH 435
Query: 428 PSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVY 487
P+ + LA G+ L + + V + T + ++FSP+G YLA D + ++
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLW 495
Query: 488 TVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWD 534
+ G + + GH+ IT L ++ DS + S D + WD
Sbjct: 496 DLASG----TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 46.6 bits (109), Expect = 7e-05
Identities = 34/118 (28%), Positives = 51/118 (43%), Gaps = 5/118 (4%)
Query: 375 GHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRII---EDPARSAGFHPSGS 431
GH+ ++ + HP+ T DK V LWS+ + R+ P S F P+G
Sbjct: 424 GHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSV--RLFTGHRGPVLSLAFSPNGK 481
Query: 432 VLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTV 489
LA R L D + L + I+ ++FSPD +A S DN V V+ +
Sbjct: 482 YLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 39.7 bits (91), Expect = 0.009
Identities = 36/141 (25%), Positives = 55/141 (39%), Gaps = 26/141 (18%)
Query: 99 RHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIW-----DSVSLSTLHVL 153
R Y GH D+ C+ HP+ +ATG T VR+W +SV L T H
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKT----------VRLWSAQQGNSVRLFTGH-- 467
Query: 154 GLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATF 213
V + FS + G L + E D L +WD A T +++ + + TF
Sbjct: 468 -----RGPVLSLAFSPN--GKYLASAGE--DQRLKLWDLASGTLYKELRGHTDNITSLTF 518
Query: 214 HPTDPTVLITCGKSHIYFWTL 234
P + + + W +
Sbjct: 519 SPDSGLIASASMDNSVRVWDI 539
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 65.9 bits (159), Expect = 1e-10
Identities = 78/308 (25%), Positives = 120/308 (38%), Gaps = 28/308 (9%)
Query: 208 VLVATFHPTDPTVLITCGKSHIYFWTLE----GGS--LSKRQGLFEK-HEKP--KYVLCV 258
V + ++P + G S W L GGS L R + E H+ P K V +
Sbjct: 182 VFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSL 241
Query: 259 TFLEGGDVVT-GDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRR 317
+ G ++ G G +W + GN + LG H G +F L + G V G D+
Sbjct: 242 DWNSDGTLLAMGSYDGFARIWTENGN--LASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299
Query: 318 VVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLV-QGH 376
++W + + ++ + P P V + T +T I + + QGH
Sbjct: 300 TIIWDAHTGEAKQ-QFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
Query: 377 VEELWGLATHPSRAQFVTCGQDKLVHLWSS---------DSHQPLWSRIIEDPARSAGFH 427
E+ + PS +C D + +WS +H I P A +
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 428 PSGSV-LAVGTVTGRWLLLDTETHDLVAIHT--DGNEQISVVSFSPDGAYLAVGSHDNLV 484
P+ S+ LA + L D E V HT E + V+FSPDG YLA GS D V
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 485 YVYTVDQG 492
+++ G
Sbjct: 477 HIWNTQSG 484
Score = 37.4 bits (85), Expect = 0.044
Identities = 29/146 (19%), Positives = 60/146 (41%), Gaps = 15/146 (10%)
Query: 182 SNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDP-------TVLITCGK--SHIYFW 232
S+D L +W ++ V D++ ++ + + PT P ++++ S + W
Sbjct: 378 SDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW 437
Query: 233 TLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGA 292
+E G + KH++P Y + + +G + +G +++W + + G
Sbjct: 438 DVEQGVCTH---TLMKHQEPVYSVAFS-PDGKYLASGSFDKYVHIWNTQSGSLVHSYQGT 493
Query: 293 HDGGVFGLCALRDGTLVSGGGRDRRV 318
GG+F +C G V D V
Sbjct: 494 --GGIFEVCWNARGDKVGASASDGSV 517
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 65.9 bits (159), Expect = 1e-10
Identities = 78/308 (25%), Positives = 120/308 (38%), Gaps = 28/308 (9%)
Query: 208 VLVATFHPTDPTVLITCGKSHIYFWTLE----GGS--LSKRQGLFEK-HEKP--KYVLCV 258
V + ++P + G S W L GGS L R + E H+ P K V +
Sbjct: 182 VFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSL 241
Query: 259 TFLEGGDVVT-GDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRR 317
+ G ++ G G +W + GN + LG H G +F L + G V G D+
Sbjct: 242 DWNSDGTLLAMGSYDGFARIWTENGN--LASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299
Query: 318 VVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLV-QGH 376
++W + + ++ + P P V + T +T I + + QGH
Sbjct: 300 TIIWDAHTGEAKQ-QFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
Query: 377 VEELWGLATHPSRAQFVTCGQDKLVHLWSS---------DSHQPLWSRIIEDPARSAGFH 427
E+ + PS +C D + +WS +H I P A +
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 428 PSGSV-LAVGTVTGRWLLLDTETHDLVAIHT--DGNEQISVVSFSPDGAYLAVGSHDNLV 484
P+ S+ LA + L D E V HT E + V+FSPDG YLA GS D V
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 485 YVYTVDQG 492
+++ G
Sbjct: 477 HIWNTQSG 484
Score = 37.4 bits (85), Expect = 0.044
Identities = 29/146 (19%), Positives = 60/146 (41%), Gaps = 15/146 (10%)
Query: 182 SNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDP-------TVLITCGK--SHIYFW 232
S+D L +W ++ V D++ ++ + + PT P ++++ S + W
Sbjct: 378 SDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW 437
Query: 233 TLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGA 292
+E G + KH++P Y + + +G + +G +++W + + G
Sbjct: 438 DVEQGVCTH---TLMKHQEPVYSVAFS-PDGKYLASGSFDKYVHIWNTQSGSLVHSYQGT 493
Query: 293 HDGGVFGLCALRDGTLVSGGGRDRRV 318
GG+F +C G V D V
Sbjct: 494 --GGIFEVCWNARGDKVGASASDGSV 517
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 65.9 bits (159), Expect = 1e-10
Identities = 78/308 (25%), Positives = 120/308 (38%), Gaps = 28/308 (9%)
Query: 208 VLVATFHPTDPTVLITCGKSHIYFWTLE----GGS--LSKRQGLFEK-HEKP--KYVLCV 258
V + ++P + G S W L GGS L R + E H+ P K V +
Sbjct: 182 VFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSL 241
Query: 259 TFLEGGDVVT-GDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRR 317
+ G ++ G G +W + GN + LG H G +F L + G V G D+
Sbjct: 242 DWNSDGTLLAMGSYDGFARIWTENGN--LASTLGQHKGPIFALKWNKKGNYVLSAGVDKT 299
Query: 318 VVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLV-QGH 376
++W + + ++ + P P V + T +T I + + QGH
Sbjct: 300 TIIWDAHTGEAKQ-QFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
Query: 377 VEELWGLATHPSRAQFVTCGQDKLVHLWSS---------DSHQPLWSRIIEDPARSAGFH 427
E+ + PS +C D + +WS +H I P A +
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 428 PSGSV-LAVGTVTGRWLLLDTETHDLVAIHT--DGNEQISVVSFSPDGAYLAVGSHDNLV 484
P+ S+ LA + L D E V HT E + V+FSPDG YLA GS D V
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 485 YVYTVDQG 492
+++ G
Sbjct: 477 HIWNTQSG 484
Score = 37.4 bits (85), Expect = 0.044
Identities = 29/146 (19%), Positives = 60/146 (41%), Gaps = 15/146 (10%)
Query: 182 SNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDP-------TVLITCGK--SHIYFW 232
S+D L +W ++ V D++ ++ + + PT P ++++ S + W
Sbjct: 378 SDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW 437
Query: 233 TLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGA 292
+E G + KH++P Y + + +G + +G +++W + + G
Sbjct: 438 DVEQGVCTH---TLMKHQEPVYSVAFS-PDGKYLASGSFDKYVHIWNTQSGSLVHSYQGT 493
Query: 293 HDGGVFGLCALRDGTLVSGGGRDRRV 318
GG+F +C G V D V
Sbjct: 494 --GGIFEVCWNARGDKVGASASDGSV 517
>gi|190684677 mitogen-activated protein kinase binding protein 1
isoform b [Homo sapiens]
Length = 1514
Score = 65.5 bits (158), Expect = 1e-10
Identities = 54/183 (29%), Positives = 75/183 (40%), Gaps = 20/183 (10%)
Query: 60 VYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHN-DDIKCLAIHPDMV 118
V G RG C +G + Y V VL++ + +Q H L + I LA PD
Sbjct: 49 VSGGRGLACDPR-----SGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
Query: 119 TIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCA 178
+ TG+ P VR+WD S V L V CV FS S + +
Sbjct: 104 YLVTGESGHM--------PAVRVWDVAEHS--QVAELQEHKYGVACVAFSPS--AKYIVS 151
Query: 179 VDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGS 238
V +D +++VW W K V K S+ V+ D + +T G HI FW L+
Sbjct: 152 VGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVS--FSEDCSYFVTAGNRHIKFWYLDDSK 209
Query: 239 LSK 241
SK
Sbjct: 210 TSK 212
Score = 33.5 bits (75), Expect = 0.63
Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 30/181 (16%)
Query: 350 TLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPS----------RAQFVTCGQDK 399
++YV R+ G V++ H +W + +P + F+TC D
Sbjct: 367 SIYVWDVRDPKKVGKVYSALY-----HSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDN 421
Query: 400 LVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGR-WLLLDTET---HDLVAI 455
+ LW+++S S + + S ++ + V G LLDTE A
Sbjct: 422 TIRLWNTESSGVHGSTLHRNIL-------SSDLIKIIYVDGNTQALLDTELPGGDKADAS 474
Query: 456 HTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWA 515
D I V SP+G +LA G + V+ + + +S + K H S I L+++
Sbjct: 475 LLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHEL----QSLSEMLKVEAHDSEILCLEYS 530
Query: 516 Q 516
+
Sbjct: 531 K 531
Score = 31.6 bits (70), Expect = 2.4
Identities = 17/68 (25%), Positives = 28/68 (41%), Gaps = 4/68 (5%)
Query: 466 VSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNS 525
V P G Y+A D + ++ G + GHS +T + ++ D ++ S
Sbjct: 667 VQTDPSGIYIATSCSDKNLSIFDFSSG----ECVATMFGHSEIVTGMKFSNDCKHLISVS 722
Query: 526 GDYEILYW 533
GD I W
Sbjct: 723 GDSCIFVW 730
>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
Length = 1523
Score = 65.1 bits (157), Expect = 2e-10
Identities = 58/212 (27%), Positives = 88/212 (41%), Gaps = 24/212 (11%)
Query: 39 APTYSLDTRSELPSC-------RLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLY 91
AP L R+ L + R+ LE V G ++ TG + Y V V+
Sbjct: 37 APPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVIL 96
Query: 92 SVEEQRQRHYLGH-NDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTL 150
+E +Q+H + LA PD I TG+ P VRIWD + +
Sbjct: 97 DPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHR--------PAVRIWDVEEKNQV 148
Query: 151 -HVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVL 209
+LG V CV FS + + ++ +D +L+VWDW K+ V K S +
Sbjct: 149 AEMLG---HKYGVACVAFSPNM--KHIVSMGYQHDMVLNVWDWKKDIVVASNKVS--CRV 201
Query: 210 VATFHPTDPTVLITCGKSHIYFWTLEGGSLSK 241
+A D + +T G H+ FW LE + +K
Sbjct: 202 IALSFSEDSSYFVTVGNRHVRFWFLEVSTETK 233
Score = 33.5 bits (75), Expect = 0.63
Identities = 20/68 (29%), Positives = 27/68 (39%), Gaps = 4/68 (5%)
Query: 466 VSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNS 525
V P G +LA D + V G + K GHS IT + + D +T S
Sbjct: 679 VHVDPSGTFLATSCSDKSISVIDFYSG----ECIAKMFGHSEIITSMKFTYDCHHLITVS 734
Query: 526 GDYEILYW 533
GD + W
Sbjct: 735 GDSCVFIW 742
Score = 31.6 bits (70), Expect = 2.4
Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 443 LLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVG--SHDNLVYVYTVDQGGRKVSRLG 500
++LD + + I + +S ++FSPDG Y+ G H V ++ V++ + LG
Sbjct: 94 VILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLG 153
>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
Length = 1518
Score = 65.1 bits (157), Expect = 2e-10
Identities = 58/212 (27%), Positives = 88/212 (41%), Gaps = 24/212 (11%)
Query: 39 APTYSLDTRSELPSC-------RLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLY 91
AP L R+ L + R+ LE V G ++ TG + Y V V+
Sbjct: 37 APPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVIL 96
Query: 92 SVEEQRQRHYLGH-NDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTL 150
+E +Q+H + LA PD I TG+ P VRIWD + +
Sbjct: 97 DPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHR--------PAVRIWDVEEKNQV 148
Query: 151 -HVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVL 209
+LG V CV FS + + ++ +D +L+VWDW K+ V K S +
Sbjct: 149 AEMLG---HKYGVACVAFSPNM--KHIVSMGYQHDMVLNVWDWKKDIVVASNKVS--CRV 201
Query: 210 VATFHPTDPTVLITCGKSHIYFWTLEGGSLSK 241
+A D + +T G H+ FW LE + +K
Sbjct: 202 IALSFSEDSSYFVTVGNRHVRFWFLEVSTETK 233
Score = 33.5 bits (75), Expect = 0.63
Identities = 20/68 (29%), Positives = 27/68 (39%), Gaps = 4/68 (5%)
Query: 466 VSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNS 525
V P G +LA D + V G + K GHS IT + + D +T S
Sbjct: 679 VHVDPSGTFLATSCSDKSISVIDFYSG----ECIAKMFGHSEIITSMKFTYDCHHLITVS 734
Query: 526 GDYEILYW 533
GD + W
Sbjct: 735 GDSCVFIW 742
Score = 31.6 bits (70), Expect = 2.4
Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 443 LLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVG--SHDNLVYVYTVDQGGRKVSRLG 500
++LD + + I + +S ++FSPDG Y+ G H V ++ V++ + LG
Sbjct: 94 VILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLG 153
>gi|22749037 WD repeat domain 65 [Homo sapiens]
Length = 698
Score = 63.5 bits (153), Expect = 6e-10
Identities = 56/266 (21%), Positives = 105/266 (39%), Gaps = 24/266 (9%)
Query: 376 HVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAV 435
H + GLAT + TC D+ + LW+ +++ + ++ A S HPSG + V
Sbjct: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVV 447
Query: 436 GTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRK 495
G + L++ D+ + SFS +G +L + N+++VYT
Sbjct: 448 G-FADKLRLMNLLIDDIRSFKEYSVRGCGECSFS-NGGHLFAAVNGNVIHVYTT----TS 501
Query: 496 VSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATA 555
+ + GH+ I + W D S ++ D + W+ +T K+ T +++ +
Sbjct: 502 LENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETEC-VLKSCSYNCV 560
Query: 556 T------CVLGFGVFGIWSEGADG----------TDINAVARSHDGKLLASADDFGKVHL 599
T + G E AD A+ SH G+++ G +
Sbjct: 561 TVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIRA 620
Query: 600 FSYPCCQPRALSHKYGGHSSHVTNVA 625
YP + ++Y H+ +T V+
Sbjct: 621 MKYPLPLQKEF-NEYQAHAGPITKVS 645
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 16/236 (6%)
Query: 60 VYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGH--NDDIKCLAIHPDM 117
V+G R N++ I++ + V Y+V+++ Q+ G + + L+I P+
Sbjct: 11 VFGLRSHVAN-NIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPNR 69
Query: 118 VTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVC-CVGFSKSNGGNLL 176
+A ++ T +E P + I++ S+ L FD V + + S L
Sbjct: 70 RYLA---ISETVQE----KPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYL 122
Query: 177 CAVDESNDHMLSVWDWAKET--KVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTL 234
A + L W W K+ +V + N V +F P D T + G
Sbjct: 123 LAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRF 182
Query: 235 EGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVL 290
G+L +Q F++ E P+ L T++ +V G G L+++ G R +++
Sbjct: 183 AEGTL--KQTSFQRGE-PQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIM 235
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 59.7 bits (143), Expect = 8e-09
Identities = 62/265 (23%), Positives = 113/265 (42%), Gaps = 23/265 (8%)
Query: 387 PSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPA----RSAGFHPSGSVLAVGTVTGRW 442
PS +C D LW++++ Q L ++E P+ R F P + LA G G
Sbjct: 64 PSGHILASCSTDGTTVLWNTENGQML--AVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
Query: 443 LLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKC 502
+L + +++ L + + ++ +FSP+G++ GS + V+ K+ L
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW-----DDKMRCLHSE 176
Query: 503 SGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFG 562
H IT D++ + G+ + ++ A+C Q D + + T +LGF
Sbjct: 177 KAHDLGITCCDFSSQP----VSDGEQGLQFFRLASCGQ----DCQVKIWIVSFTHILGFE 228
Query: 563 VFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVT 622
+ + + A A SHDG++L S V ++ + H H+ +VT
Sbjct: 229 LKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYD---TNTENILHTLTQHTRYVT 285
Query: 623 NVAFLWDDSMALTTGGKDTSVLQWR 647
AF +++ L TG D +V W+
Sbjct: 286 TCAFA-PNTLLLATGSMDKTVNIWQ 309
Score = 44.7 bits (104), Expect = 3e-04
Identities = 54/259 (20%), Positives = 91/259 (35%), Gaps = 27/259 (10%)
Query: 255 VLCVTFLEGGDVVTGDS-GGNLYVWGKGGNRITQAVLGAHDGGVFGLCALR-DGTLVSGG 312
V C F G ++ S G +W ++ AV+ G +C D T ++ G
Sbjct: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQML-AVMEQPSGSPVRVCQFSPDSTCLASG 115
Query: 313 GRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLL 372
D VVLW + KL +D +G G++ + +V
Sbjct: 116 AADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDL---TVWDDKMRC 172
Query: 373 VQGHVEELWGLATHPSRAQFVT-------------CGQDKLVHLWSSDSHQPLWSRIIED 419
+ G+ +Q V+ CGQD V +W L +
Sbjct: 173 LHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYK 232
Query: 420 --------PARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPD 471
P + F G +L G+V ++ DT T +++ T ++ +F+P+
Sbjct: 233 STLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292
Query: 472 GAYLAVGSHDNLVYVYTVD 490
LA GS D V ++ D
Sbjct: 293 TLLLATGSMDKTVNIWQFD 311
Score = 38.1 bits (87), Expect = 0.026
Identities = 69/323 (21%), Positives = 112/323 (34%), Gaps = 41/323 (12%)
Query: 104 HNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVC 163
H DD+ C A ++ + L +R++ + L L AV
Sbjct: 11 HGDDVNCCAFSFSLLATCS------------LDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
Query: 164 CVGFSKSNGGNLLCAVDESNDHMLSVWDWAK-ETKVVDVKCSNEAVLVATFHPTDPTVLI 222
C FS S G++L + S D +W+ + V + S V V F P +
Sbjct: 59 CCCFSPS--GHILASC--STDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLAS 114
Query: 223 TCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGG 282
+ W + L + + + C G VTG S G+L VW
Sbjct: 115 GAADGTVVLWNAQSYKLYRCGSV----KDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
Query: 283 NRITQAVLGAHDGGV----FGLCALRDGT------LVSGGGRDRRVVLWGSDYSKLQEVE 332
+ AHD G+ F + DG ++ G+D +V +W ++ + E
Sbjct: 171 RCLHSE--KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFE 228
Query: 333 ------VPEDFGPVRTVAEGH-GDTLYVGTTRNSILQGSVHTGFSL-LVQGHVEELWGLA 384
+ PV A H G L G+ S++ +T L + H + A
Sbjct: 229 LKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
Query: 385 THPSRAQFVTCGQDKLVHLWSSD 407
P+ T DK V++W D
Sbjct: 289 FAPNTLLLATGSMDKTVNIWQFD 311
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 59.7 bits (143), Expect = 8e-09
Identities = 62/265 (23%), Positives = 113/265 (42%), Gaps = 23/265 (8%)
Query: 387 PSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPA----RSAGFHPSGSVLAVGTVTGRW 442
PS +C D LW++++ Q L ++E P+ R F P + LA G G
Sbjct: 64 PSGHILASCSTDGTTVLWNTENGQML--AVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
Query: 443 LLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKC 502
+L + +++ L + + ++ +FSP+G++ GS + V+ K+ L
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW-----DDKMRCLHSE 176
Query: 503 SGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFG 562
H IT D++ + G+ + ++ A+C Q D + + T +LGF
Sbjct: 177 KAHDLGITCCDFSSQP----VSDGEQGLQFFRLASCGQ----DCQVKIWIVSFTHILGFE 228
Query: 563 VFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVT 622
+ + + A A SHDG++L S V ++ + H H+ +VT
Sbjct: 229 LKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYD---TNTENILHTLTQHTRYVT 285
Query: 623 NVAFLWDDSMALTTGGKDTSVLQWR 647
AF +++ L TG D +V W+
Sbjct: 286 TCAFA-PNTLLLATGSMDKTVNIWQ 309
Score = 44.7 bits (104), Expect = 3e-04
Identities = 54/259 (20%), Positives = 91/259 (35%), Gaps = 27/259 (10%)
Query: 255 VLCVTFLEGGDVVTGDS-GGNLYVWGKGGNRITQAVLGAHDGGVFGLCALR-DGTLVSGG 312
V C F G ++ S G +W ++ AV+ G +C D T ++ G
Sbjct: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQML-AVMEQPSGSPVRVCQFSPDSTCLASG 115
Query: 313 GRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLL 372
D VVLW + KL +D +G G++ + +V
Sbjct: 116 AADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDL---TVWDDKMRC 172
Query: 373 VQGHVEELWGLATHPSRAQFVT-------------CGQDKLVHLWSSDSHQPLWSRIIED 419
+ G+ +Q V+ CGQD V +W L +
Sbjct: 173 LHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYK 232
Query: 420 --------PARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPD 471
P + F G +L G+V ++ DT T +++ T ++ +F+P+
Sbjct: 233 STLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292
Query: 472 GAYLAVGSHDNLVYVYTVD 490
LA GS D V ++ D
Sbjct: 293 TLLLATGSMDKTVNIWQFD 311
Score = 38.1 bits (87), Expect = 0.026
Identities = 69/323 (21%), Positives = 112/323 (34%), Gaps = 41/323 (12%)
Query: 104 HNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVC 163
H DD+ C A ++ + L +R++ + L L AV
Sbjct: 11 HGDDVNCCAFSFSLLATCS------------LDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
Query: 164 CVGFSKSNGGNLLCAVDESNDHMLSVWDWAK-ETKVVDVKCSNEAVLVATFHPTDPTVLI 222
C FS S G++L + S D +W+ + V + S V V F P +
Sbjct: 59 CCCFSPS--GHILASC--STDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLAS 114
Query: 223 TCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGG 282
+ W + L + + + C G VTG S G+L VW
Sbjct: 115 GAADGTVVLWNAQSYKLYRCGSV----KDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
Query: 283 NRITQAVLGAHDGGV----FGLCALRDGT------LVSGGGRDRRVVLWGSDYSKLQEVE 332
+ AHD G+ F + DG ++ G+D +V +W ++ + E
Sbjct: 171 RCLHSE--KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFE 228
Query: 333 ------VPEDFGPVRTVAEGH-GDTLYVGTTRNSILQGSVHTGFSL-LVQGHVEELWGLA 384
+ PV A H G L G+ S++ +T L + H + A
Sbjct: 229 LKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
Query: 385 THPSRAQFVTCGQDKLVHLWSSD 407
P+ T DK V++W D
Sbjct: 289 FAPNTLLLATGSMDKTVNIWQFD 311
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 59.7 bits (143), Expect = 8e-09
Identities = 62/265 (23%), Positives = 113/265 (42%), Gaps = 23/265 (8%)
Query: 387 PSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPA----RSAGFHPSGSVLAVGTVTGRW 442
PS +C D LW++++ Q L ++E P+ R F P + LA G G
Sbjct: 64 PSGHILASCSTDGTTVLWNTENGQML--AVMEQPSGSPVRVCQFSPDSTCLASGAADGTV 121
Query: 443 LLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKC 502
+L + +++ L + + ++ +FSP+G++ GS + V+ K+ L
Sbjct: 122 VLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVW-----DDKMRCLHSE 176
Query: 503 SGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFG 562
H IT D++ + G+ + ++ A+C Q D + + T +LGF
Sbjct: 177 KAHDLGITCCDFSSQP----VSDGEQGLQFFRLASCGQ----DCQVKIWIVSFTHILGFE 228
Query: 563 VFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVT 622
+ + + A A SHDG++L S V ++ + H H+ +VT
Sbjct: 229 LKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYD---TNTENILHTLTQHTRYVT 285
Query: 623 NVAFLWDDSMALTTGGKDTSVLQWR 647
AF +++ L TG D +V W+
Sbjct: 286 TCAFA-PNTLLLATGSMDKTVNIWQ 309
Score = 44.7 bits (104), Expect = 3e-04
Identities = 54/259 (20%), Positives = 91/259 (35%), Gaps = 27/259 (10%)
Query: 255 VLCVTFLEGGDVVTGDS-GGNLYVWGKGGNRITQAVLGAHDGGVFGLCALR-DGTLVSGG 312
V C F G ++ S G +W ++ AV+ G +C D T ++ G
Sbjct: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQML-AVMEQPSGSPVRVCQFSPDSTCLASG 115
Query: 313 GRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLL 372
D VVLW + KL +D +G G++ + +V
Sbjct: 116 AADGTVVLWNAQSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDL---TVWDDKMRC 172
Query: 373 VQGHVEELWGLATHPSRAQFVT-------------CGQDKLVHLWSSDSHQPLWSRIIED 419
+ G+ +Q V+ CGQD V +W L +
Sbjct: 173 LHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYK 232
Query: 420 --------PARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPD 471
P + F G +L G+V ++ DT T +++ T ++ +F+P+
Sbjct: 233 STLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPN 292
Query: 472 GAYLAVGSHDNLVYVYTVD 490
LA GS D V ++ D
Sbjct: 293 TLLLATGSMDKTVNIWQFD 311
Score = 38.1 bits (87), Expect = 0.026
Identities = 69/323 (21%), Positives = 112/323 (34%), Gaps = 41/323 (12%)
Query: 104 HNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVC 163
H DD+ C A ++ + L +R++ + L L AV
Sbjct: 11 HGDDVNCCAFSFSLLATCS------------LDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
Query: 164 CVGFSKSNGGNLLCAVDESNDHMLSVWDWAK-ETKVVDVKCSNEAVLVATFHPTDPTVLI 222
C FS S G++L + S D +W+ + V + S V V F P +
Sbjct: 59 CCCFSPS--GHILASC--STDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLAS 114
Query: 223 TCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGG 282
+ W + L + + + C G VTG S G+L VW
Sbjct: 115 GAADGTVVLWNAQSYKLYRCGSV----KDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM 170
Query: 283 NRITQAVLGAHDGGV----FGLCALRDGT------LVSGGGRDRRVVLWGSDYSKLQEVE 332
+ AHD G+ F + DG ++ G+D +V +W ++ + E
Sbjct: 171 RCLHSE--KAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFE 228
Query: 333 ------VPEDFGPVRTVAEGH-GDTLYVGTTRNSILQGSVHTGFSL-LVQGHVEELWGLA 384
+ PV A H G L G+ S++ +T L + H + A
Sbjct: 229 LKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCA 288
Query: 385 THPSRAQFVTCGQDKLVHLWSSD 407
P+ T DK V++W D
Sbjct: 289 FAPNTLLLATGSMDKTVNIWQFD 311
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/255 (23%), Positives = 105/255 (41%), Gaps = 22/255 (8%)
Query: 306 GTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTV-AEGHGDTLYVGTTRNSILQGS 364
G L++ RDR V LW D + + E PVR+V G L + SI S
Sbjct: 72 GNLLASASRDRTVRLWIPD-KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
Query: 365 VH-TGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARS 423
++ F + H + P V+C +DK + +W + + Q + + + S
Sbjct: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ-----CVNNFSDS 185
Query: 424 AG------FHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAV 477
G F+PSG+ +A + D + L+ + + ++ +SF P G YL
Sbjct: 186 VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
Query: 478 GSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYW---- 533
S D + + + + GR + L GH+ + + +++ F + D ++L W
Sbjct: 246 ASSDGTLKILDLLE-GRLIYTL---QGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301
Query: 534 DPATCKQITSADAVR 548
D CK +T + R
Sbjct: 302 DELHCKGLTKRNLKR 316
Score = 53.5 bits (127), Expect = 6e-07
Identities = 65/293 (22%), Positives = 110/293 (37%), Gaps = 28/293 (9%)
Query: 374 QGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRI-IEDPARSAGFHPSGSV 432
+GH + L P+ Q T D + LW+ H + + +D S F P G++
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 433 LAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQG 492
LA + L + + + V FS DG +LA S D + V+++
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM--- 131
Query: 493 GRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITS--ADAVRNM 550
+ L H+ ++ ++ D V+ S D I WD T KQ + +D+V
Sbjct: 132 -YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD-TTNKQCVNNFSDSVGFA 189
Query: 551 EWA----TATCVLGFG---VFGIWSEGAD---------GTDINAVARSHDGKLLASADDF 594
+ + TC+ G +W + +N ++ G L +A
Sbjct: 190 NFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSD 249
Query: 595 GKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWR 647
G + + L + GH+ V V+F + +GG DT VL WR
Sbjct: 250 GTLKILD---LLEGRLIYTLQGHTGPVFTVSFSKGGEL-FASGGADTQVLLWR 298
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/209 (23%), Positives = 84/209 (40%), Gaps = 17/209 (8%)
Query: 121 ATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVD 180
A GQ T E K +++W L+ L V C FS G L+ +
Sbjct: 112 ADGQFLATASEDKS----IKVWSMYRQRFLY--SLYRHTHWVRCAKFSPD--GRLIVSCS 163
Query: 181 ESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLS 240
E D + +WD + V + S F+P+ + + W + L
Sbjct: 164 E--DKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLL 221
Query: 241 KRQGLFEKHEKPKYVLCVTFLEGGD-VVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFG 299
+ ++ H V C++F G+ ++T S G L + R+ + G H G VF
Sbjct: 222 QH---YQVHSGG--VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG-HTGPVFT 275
Query: 300 LCALRDGTLVSGGGRDRRVVLWGSDYSKL 328
+ + G L + GG D +V+LW +++ +L
Sbjct: 276 VSFSKGGELFASGGADTQVLLWRTNFDEL 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,814,974
Number of Sequences: 37866
Number of extensions: 1255747
Number of successful extensions: 3862
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 108
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 2571
Number of HSP's gapped (non-prelim): 985
length of query: 649
length of database: 18,247,518
effective HSP length: 109
effective length of query: 540
effective length of database: 14,120,124
effective search space: 7624866960
effective search space used: 7624866960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.