Guide to the Human Genome
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Search of human proteins with 6912326

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6912326 family with sequence similarity 50, member B [Homo
sapiens]
         (325 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6912326 family with sequence similarity 50, member B [Homo sa...   648   0.0  
gi|4758220 XAP-5 protein [Homo sapiens]                               518   e-147
gi|148746195 trichohyalin [Homo sapiens]                               57   3e-08
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                56   5e-08
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       52   7e-07
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       52   7e-07
gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                        52   7e-07
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        52   7e-07
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        52   7e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       51   1e-06
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    50   3e-06
gi|148839339 nexilin (F actin binding protein) [Homo sapiens]          49   5e-06
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    49   6e-06
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    49   6e-06
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    49   6e-06
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    49   6e-06
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    49   6e-06
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]            49   8e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    48   1e-05
gi|109150435 ankyrin repeat and zinc finger domain containing 1 ...    48   1e-05
gi|109150425 ankyrin repeat and zinc finger domain containing 1 ...    48   1e-05
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    48   1e-05
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    48   1e-05
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    47   2e-05
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]            47   2e-05
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    47   2e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    47   2e-05
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            47   3e-05
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti...    47   3e-05
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             47   3e-05

>gi|6912326 family with sequence similarity 50, member B [Homo
           sapiens]
          Length = 325

 Score =  648 bits (1672), Expect = 0.0
 Identities = 325/325 (100%), Positives = 325/325 (100%)

Query: 1   MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL 60
           MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL
Sbjct: 1   MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL 60

Query: 61  KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL 120
           KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL
Sbjct: 61  KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL 120

Query: 121 SFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKV 180
           SFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKV
Sbjct: 121 SFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKV 180

Query: 181 KDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQLMFIKE 240
           KDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQLMFIKE
Sbjct: 181 KDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQLMFIKE 240

Query: 241 DLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSWYEK 300
           DLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSWYEK
Sbjct: 241 DLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSWYEK 300

Query: 301 NKHIFPASRWEAYDPEKKWDKYTIR 325
           NKHIFPASRWEAYDPEKKWDKYTIR
Sbjct: 301 NKHIFPASRWEAYDPEKKWDKYTIR 325


>gi|4758220 XAP-5 protein [Homo sapiens]
          Length = 339

 Score =  518 bits (1334), Expect = e-147
 Identities = 252/339 (74%), Positives = 296/339 (87%), Gaps = 14/339 (4%)

Query: 1   MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL 60
           MAQYKG   EAGRAMHL+KKRE+QREQME +KQRIAEE I+KS +DK+FSAHYDAVEAEL
Sbjct: 1   MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAEL 60

Query: 61  KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL 120
           KSSTVGLVTLNDMKA+QEALV+ERE+QLAK++  +E +++ E+ RE+E+++E KRKIS L
Sbjct: 61  KSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQMKLEKLREKERKKEAKRKISSL 120

Query: 121 SFALDDLDDQADAAE--------------ARRAGNLGKNPDVDTSFLPDRDREEEENRLR 166
           SF L++ ++  +  E                +   LGKNPDVDTSFLPDRDREEEENRLR
Sbjct: 121 SFTLEEEEEGGEEEEEAAMYEEEMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRLR 180

Query: 167 EELRQEWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLE 226
           EELRQEWEA++EK+K EE+E+TFSYWDGSGHRRTV++RKGNT+QQFL+KAL+ LRKDF E
Sbjct: 181 EELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSE 240

Query: 227 LRSAGVEQLMFIKEDLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDE 286
           LRSAGVEQLM+IKEDLI+PH+H+FYDFI+ +ARGKSGPLF+FDVHDDVRLLSDAT+EKDE
Sbjct: 241 LRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDE 300

Query: 287 SHAGKVVLRSWYEKNKHIFPASRWEAYDPEKKWDKYTIR 325
           SHAGKVVLRSWYEKNKHIFPASRWE YDPEKKWDKYTIR
Sbjct: 301 SHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR 339


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 59/219 (26%), Positives = 95/219 (43%), Gaps = 36/219 (16%)

Query: 13  RAMHLLKKRERQR------EQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVG 66
           R   LLK+ E +R      EQ E L+QR+  E + + + ++R        E E +     
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL 633

Query: 67  LVTLNDMKARQEALVRERE----------------RQLAKRQHLEEQRLQQERQREQEQR 110
           L +    + RQ+ L RE++                 Q  KR+H EE+R Q+  + EQEQ 
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693

Query: 111 RER-KRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREEL 169
           RER K +I    +    L+ +ADA +++      K           R +E+EE R R E 
Sbjct: 694 RERIKSRIPKWQW---QLESEADARQSKVYSRPRKQEG------QRRRQEQEEKRRRRES 744

Query: 170 RQEW---EAQREKVKDEEMEVTFSYWDGSGHRRTVRVRK 205
             +W   E    + ++EE    F+ W      ++ R R+
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFT-WQWQAEEKSERGRQ 782



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 54/189 (28%), Positives = 89/189 (47%), Gaps = 20/189 (10%)

Query: 8   MREAGRAMHLLKKRERQRE--QMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTV 65
           +R  GR     ++RERQ    Q E  K+    ET+L+ + +K         + EL+    
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK-LQEEEPQRQRELQEEEE 276

Query: 66  GLVTLNDMKARQEALVRE-------RERQLAKRQHLEEQRLQQERQREQEQRRERKRKIS 118
            L  L   + R+E    E       RE+QL ++Q  EE+R QQE +REQ++RRE++ +  
Sbjct: 277 QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE-EERREQQEERREQQERREQQEERR 335

Query: 119 CLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQRE 178
                 +         E RR   L +  + +      R RE+EE R  ++LR+E + +RE
Sbjct: 336 EQQLRREQ--------EERREQQLRREQEEERREQQLR-REQEEERREQQLRREQQLRRE 386

Query: 179 KVKDEEMEV 187
           +    E ++
Sbjct: 387 QQLRREQQL 395



 Score = 51.6 bits (122), Expect = 9e-07
 Identities = 49/177 (27%), Positives = 82/177 (46%), Gaps = 33/177 (18%)

Query: 13  RAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLND 72
           R   LLK+ E +R + E  +QR+  E     Q ++R        +  LK          +
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKRE-----QEERR--------DQLLK---------RE 582

Query: 73  MKARQEALVRERERQLAKRQHLEE-QRLQQERQREQEQRRERKRKISCLSFALDDLDDQA 131
            + RQ+ L RE+E +L +R   EE +RL+QE +REQ  +RE   +         +  ++ 
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642

Query: 132 DAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQR--EKVKDEEME 186
              + RR     +   +         REEEE RL + L++E E +R  +++ +EE E
Sbjct: 643 RQQQLRREQQERREQRL--------KREEEEERLEQRLKREHEEERREQELAEEEQE 691



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 45/180 (25%), Positives = 87/180 (48%), Gaps = 17/180 (9%)

Query: 13   RAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLND 72
            R    L++RERQ  + E L+Q   EE +L  + + R       +E + +          +
Sbjct: 1038 REKRRLQERERQYREEEELQQE--EEQLLGEERETR---RRQELERQYRKE-------EE 1085

Query: 73   MKARQEALVRE----RERQLAKRQHLEEQRLQQ-ERQREQEQRRERKRKISCLSFALDDL 127
            ++  +E L+RE    R RQ  +RQ  EE+ LQQ E Q  +E+R +R+R+     +  ++ 
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145

Query: 128  DDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEV 187
              Q +    R      +  +++  +  + + ++EE +L  E +++   +RE+   EE E+
Sbjct: 1146 VQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEEL 1205



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 52/218 (23%), Positives = 101/218 (46%), Gaps = 23/218 (10%)

Query: 23  RQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEALVR 82
           RQR++ +  ++R AEE  L+S          D  +   +     L+ L   K R+E   +
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE----LLELR-RKGREEKQQQ 229

Query: 83  ERERQ-----------LAKRQHL---EEQRLQQE---RQREQEQRRERKRKISCLSFALD 125
            RERQ             KR+ +   EE++LQ+E   RQRE ++  E+ RK+       +
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289

Query: 126 DLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEM 185
             +++      RR   L +  + +     +  RE++E R ++E R+E + +RE+ +  E 
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349

Query: 186 EVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKD 223
           ++     +    ++  R ++    +Q L++  Q LR++
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRRE-QQLRRE 386



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 45/169 (26%), Positives = 84/169 (49%), Gaps = 20/169 (11%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           ++R +++E+ E L+QR+  E  L+ + ++R        E +            + + R++
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL----------EQERREQ 565

Query: 79  ALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARR 138
            L RE+E +  +    EE+R QQ  +REQE+R E++ K       ++ L+      E RR
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE----EVERLEQ-----EERR 616

Query: 139 AGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQRE-KVKDEEME 186
              L +    +         EE+E R +++LR+E + +RE ++K EE E
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 44/197 (22%), Positives = 87/197 (44%), Gaps = 28/197 (14%)

Query: 8    MREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAV----------- 56
            +R   R   L   R+R+  + E L Q   E+ + + + D++F      +           
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711

Query: 57   -EAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKR 115
             E +L+   +      + + RQE    +  RQ   R+ LEE++L+ ER+ +Q +R+ER R
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR 1771

Query: 116  KISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRD--REEEENRLREELRQ-- 171
            K            ++    + R    L ++ + D  F  +    +E EE +LR + R   
Sbjct: 1772 KFR----------EEEQLRQEREEQQL-RSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820

Query: 172  -EWEAQREKVKDEEMEV 187
              WE ++ +++++E  +
Sbjct: 1821 YRWEEEQLQLEEQEQRL 1837



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 59/246 (23%), Positives = 112/246 (45%), Gaps = 22/246 (8%)

Query: 5    KGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDA---VEAELK 61
            KG   E  R +   + R+RQ +Q   L+  + E+     + ++R     D     E +L+
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQD--LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300

Query: 62   SSTVGLVTLNDMKARQEA-LVRE-----RERQLAKRQHLEEQRLQQERQREQEQRRERKR 115
                      D K+++E  L+RE     R RQ   R+  EE++L QER+ +  +R+ER R
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360

Query: 116  KISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEA 175
            K     F  ++L  Q    +        +  + +  FL    +EE++ R +E  +Q  + 
Sbjct: 1361 K-----FREEELRHQEQGRKFLEEEQRLRRQERERKFL----KEEQQLRCQEREQQLRQD 1411

Query: 176  QREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQL 235
            +  K ++EE +++    D        +VR+    ++FL++  Q  ++   + R    EQL
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE--EQL 1469

Query: 236  MFIKED 241
            +  +E+
Sbjct: 1470 LQEREE 1475



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 41/172 (23%), Positives = 81/172 (47%), Gaps = 15/172 (8%)

Query: 13  RAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLND 72
           R   L ++++ +REQ    +Q++  E  L+ +   R     +  E + +          +
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450

Query: 73  MKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQAD 132
            + R++ L RE E +    +H +E+R QQ ++ ++E+RRER  K+          +++  
Sbjct: 451 QEERRDWLKREEETE----RHEQERRKQQLKRDQEEERRERWLKLE---------EEERR 497

Query: 133 AAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEE 184
             + RR   L +  +          R+EEE RL++ LR E + +RE+ +  E
Sbjct: 498 EQQERREQQLRREQEERRE--QRLKRQEEEERLQQRLRSEQQLRREQEERRE 547



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 59/237 (24%), Positives = 101/237 (42%), Gaps = 44/237 (18%)

Query: 3    QYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKS 62
            Q +  +R   R     + R+R+  + E L+Q   E+ + + + D++F      V  + + 
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594

Query: 63   STVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSF 122
                   + D +  +    +++ RQ   R+  E+++L QER+ +Q  R+ER RK      
Sbjct: 1595 RKF----MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF----- 1645

Query: 123  ALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDRE--EEENRLREELRQEWEAQR--E 178
                L+++       R   L            DRDR+  EEE  L+E   Q+   Q    
Sbjct: 1646 ----LEEEPQLRRQEREQQLRH----------DRDRKFREEEQLLQEGEEQQLRRQERDR 1691

Query: 179  KVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQL 235
            K ++EE ++          RR  R RK      FL++  Q LR+  LE +    EQL
Sbjct: 1692 KFREEEQQL----------RRQERERK------FLQEE-QQLRRQELERKFREEEQL 1731



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 42/170 (24%), Positives = 79/170 (46%), Gaps = 20/170 (11%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKAR-- 76
           +K+E QR + E  ++R   E+ L+ Q ++R  AH    E E +          +   R  
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEER--AHRQQQEEEQRRDFTWQWQAEEKSERGR 781

Query: 77  -----QEALVRERERQLA--KRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
                +  L  +RERQL   +RQ  E++ L +E ++EQ +R+ R+R+       L  L++
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE-----LQFLEE 836

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREK 179
           +       RA  L +  D       D++R   + + R++ +  W+ + E+
Sbjct: 837 EEQLQRRERAQQLQEEED---GLQEDQERRRSQEQRRDQ-KWRWQLEEER 882



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 44/127 (34%), Positives = 63/127 (49%), Gaps = 23/127 (18%)

Query: 73   MKARQEALVRE----RERQLAKRQHLEEQRLQQE------RQREQEQRRERKRKISCLSF 122
            ++  +E L RE    R RQ  +RQ+ EE++LQQE       +RE+ +R+ER+R+      
Sbjct: 906  LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR-KDK 964

Query: 123  ALDDLDDQ--ADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREE----LRQEWEAQ 176
             L   ++Q   +  E RR     K    +        ++EEE  LREE     RQEWE Q
Sbjct: 965  KLQQKEEQLLGEEPEKRRRQEREKKYREEEEL-----QQEEEQLLREEREKRRRQEWERQ 1019

Query: 177  REKVKDE 183
              K KDE
Sbjct: 1020 YRK-KDE 1025



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 45/170 (26%), Positives = 79/170 (46%), Gaps = 23/170 (13%)

Query: 20  KRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEA 79
           KRE + E+ E   Q   ++ + + Q ++R        E E +            + R++ 
Sbjct: 459 KREEETERHE---QERRKQQLKRDQEEERRERWLKLEEEERREQ---------QERREQQ 506

Query: 80  LVRERER---QLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEA 136
           L RE+E    Q  KRQ  EE+RLQQ  + EQ+ RRE++ +       L   +++    + 
Sbjct: 507 LRREQEERREQRLKRQE-EEERLQQRLRSEQQLRREQEERRE----QLLKREEEKRLEQE 561

Query: 137 RRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           RR   L +  +     L  R+ E  + RL+   R++ E   +++K EE+E
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLK---REQEERLEQRLKREEVE 608



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 62/246 (25%), Positives = 116/246 (47%), Gaps = 36/246 (14%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           +++ER+ +Q E  +Q++  E   + +   R     +  E +L+          + + R++
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE-------QEEERREQ 375

Query: 79  ALVRE----RERQLAKRQHLE-EQRLQQERQ--REQEQRRERK-RKISCLSFALDDLDDQ 130
            L RE    RE+QL + Q L  EQ+L++E+Q  REQ+ RRE++ R+   L    ++   +
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435

Query: 131 ADAAEARRAGNLGKNPDVDTSFLP---DRDREEEENRLR-------EELRQEW-----EA 175
               + RR   L +  +    +L    + +R E+E R +       EE R+ W     E 
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495

Query: 176 QREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQL 235
           +RE+ +  E ++     +    +R  R  +   +QQ L+   Q LR++  E R    EQL
Sbjct: 496 RREQQERREQQLRREQ-EERREQRLKRQEEEERLQQRLRSE-QQLRREQEERR----EQL 549

Query: 236 MFIKED 241
           +  +E+
Sbjct: 550 LKREEE 555



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 58/244 (23%), Positives = 109/244 (44%), Gaps = 30/244 (12%)

Query: 19   KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
            +++ER+R+  +  K +  EE +L  + +KR     +    E +          +++  +E
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE----------ELQQEEE 1001

Query: 79   ALVRE----RERQLAKRQHLEEQRLQQERQR----EQEQRR--ERKRKISCLSFALDDLD 128
             L+RE    R RQ  +RQ+ ++  LQQE ++    E+E+RR  ER+R+       L   +
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR-EEEELQQEE 1060

Query: 129  DQ--ADAAEARRAGNLGKNPDVDTSFLPDRD---REEEENRLREELRQEWEAQREKVKDE 183
            +Q   +  E RR   L +    +     + +   REE E R R+E  ++   + E  ++E
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120

Query: 184  EMEVTFSYWDGSGHRRTVRVRKGNTVQ----QFLKKALQGLRKDFLELRSAGVEQLMFIK 239
            E  +              + R+   VQ    Q L++  +  R+  LE +    E+L   +
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180

Query: 240  EDLI 243
            E L+
Sbjct: 1181 EQLL 1184



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 22/169 (13%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           ++RE+Q E+ E  ++R  +E   + Q+ +      +  E +L+          + + R++
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRRE---QEERREQQLRRE-------QEEERREQ 362

Query: 79  ALVRERERQLAKRQHLEEQRLQQERQ--REQEQRRERKRKISCLSFALDDLDDQADAAEA 136
            L RE+E +  ++Q   EQ+L++E+Q  REQ+ RRE++         L          + 
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ---------LRREQQLRREQQL 413

Query: 137 RRAGNLGKNPDVDTSFLPDRDREEEENRLREE-LRQEWEAQREKVKDEE 184
           RR   L +   +      +R  ++ E   RE+ L++E E +R+ +K EE
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 36/164 (21%), Positives = 74/164 (45%), Gaps = 24/164 (14%)

Query: 19   KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
            ++RE+Q  Q    K R  E+ + + + D++F      V  +                 +E
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ----------------ERE 1445

Query: 79   ALVRERERQLAKRQHL---EEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAE 135
                E E+QL + +H    EE++L QER+ +Q  R+ER RK     F  ++   +    +
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK-----FLEEEQQLRRQERD 1500

Query: 136  ARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREK 179
             +      ++ + +  FL +  +   + R R+ L++E + +R++
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 41/164 (25%), Positives = 74/164 (45%), Gaps = 50/164 (30%)

Query: 77  QEALVRERERQLAKRQ------HLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQ 130
           +E+L+++R ++  +R+       LEE+  Q+ RQ+ QEQ RE           L + ++Q
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERE-----------LAEGEEQ 154

Query: 131 ADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEVTFS 190
           ++  E                 L  RDR+  +  L  + RQEW+ + E+  +EE      
Sbjct: 155 SEKQER----------------LEQRDRQRRDEELWRQ-RQEWQEREERRAEEEQ----- 192

Query: 191 YWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQ 234
                     ++  KG+  ++F  +  Q  R++ LELR  G E+
Sbjct: 193 ----------LQSCKGHETEEFPDEE-QLRRRELLELRRKGREE 225



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 49/201 (24%), Positives = 89/201 (44%), Gaps = 42/201 (20%)

Query: 19   KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAV---EAELKSSTVGLVTLNDMKA 75
            ++RERQ  + E L+Q   EE +L+ + +KR     +     E E++     L+     K 
Sbjct: 1104 QERERQCREEEELQQE--EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161

Query: 76   RQEALVRE--------RERQLAKRQHLEEQRLQQERQ-REQEQRRERKRKISCLSFALDD 126
            R++ L R+        +E +   R+  E++R ++ERQ RE+E+ + +KRK         D
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK-----QRYRD 1216

Query: 127  LDDQADAA---EARRAGNLGKNP------------DVDTSFLPDRDRE--------EEEN 163
             D ++D     E  +   +  N              ++ S L DR  +        E++ 
Sbjct: 1217 EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE 1276

Query: 164  RLREELRQEWEAQREKVKDEE 184
            R RE+ R+ W+ +     +EE
Sbjct: 1277 RDREQERRRWQQRDRHFPEEE 1297



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 44/175 (25%), Positives = 75/175 (42%), Gaps = 19/175 (10%)

Query: 20  KRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEA 79
           KRE + E+ E   Q +AEE   + Q  +R  +     + +L+S      +    + R++ 
Sbjct: 673 KREHEEERRE---QELAEEE--QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727

Query: 80  LVRERERQLAKRQHLEEQRLQQERQR--EQEQRRERKRKISCLSFALDDLDDQADAAEAR 137
             R R+ Q  KR+  E +   QE +R   Q+Q  E++R  +    A +  +       AR
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787

Query: 138 --------RAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEE 184
                   R     +    +  FLP    EEEE   R   R+E E + + +++EE
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLP----EEEEKEQRRRQRREREKELQFLEEEE 838



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 44/172 (25%), Positives = 77/172 (44%), Gaps = 15/172 (8%)

Query: 18   LKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQ 77
            L++RER ++  E       ++   +SQ  +R       +E E K       TL    A Q
Sbjct: 840  LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH---TLYAKPALQ 896

Query: 78   EALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQ--ADAAE 135
            E L   +E+QL + +  E QR ++E++R QEQ R+ + +       L   ++Q   +  E
Sbjct: 897  EQL--RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ-----LQQEEEQLLREERE 949

Query: 136  ARRAGNLGKNPDVDTSFLPDRDR---EEEENRLREELRQEWEAQREKVKDEE 184
             RR     +    D       ++   EE E R R+E  +++  + E  ++EE
Sbjct: 950  KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001



 Score = 37.7 bits (86), Expect = 0.014
 Identities = 33/169 (19%), Positives = 77/169 (45%), Gaps = 10/169 (5%)

Query: 22   ERQREQMEVLKQRIAEETILKSQVDKRF----SAHYDAVEAELKSSTVGLVTLNDMKARQ 77
            ER+  + E L+Q   +E + + +  ++         +  E +L+          + + RQ
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ 1781

Query: 78   EALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEAR 137
            E   ++   Q + R+  EE++L+QER+ +Q + ++R  K     +  ++   Q +  E R
Sbjct: 1782 EREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK-----YRWEEEQLQLEEQEQR 1836

Query: 138  RAGNLGKNPDVDTSFLP-DRDREEEENRLREELRQEWEAQREKVKDEEM 185
                  +    +  F   ++ R EE+   +EE ++  + +  K+++E +
Sbjct: 1837 LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885



 Score = 35.8 bits (81), Expect = 0.053
 Identities = 44/189 (23%), Positives = 82/189 (43%), Gaps = 30/189 (15%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           ++R RQR + E   Q + EE     Q+ +R  A       +L+    GL    + +  QE
Sbjct: 818 EQRRRQRREREKELQFLEEE----EQLQRRERAQ------QLQEEEDGLQEDQERRRSQE 867

Query: 79  A---------LVRERERQ---------LAKRQHLEEQRLQQERQR-EQEQRRERKRKISC 119
                     L  ER+R+         L ++   E+Q LQ+E +  ++E+R +R+R+   
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927

Query: 120 LSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRD-REEEENRLREELRQEWEAQRE 178
             +  ++   Q +    R      +  + +  +  D+  +++EE  L EE  +    +RE
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987

Query: 179 KVKDEEMEV 187
           K   EE E+
Sbjct: 988 KKYREEEEL 996



 Score = 35.4 bits (80), Expect = 0.070
 Identities = 22/96 (22%), Positives = 47/96 (48%), Gaps = 7/96 (7%)

Query: 19   KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
            ++ +R+  + E L+Q   E+ +   Q D ++    + ++ E +   +        +A ++
Sbjct: 1791 QESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850

Query: 79   ALVRERERQLAKRQHLEEQRLQQERQREQEQRRERK 114
               +E+ R+       EEQ L QE ++++ Q RERK
Sbjct: 1851 FATQEKSRR-------EEQELWQEEEQKRRQERERK 1879



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 32/115 (27%), Positives = 53/115 (46%), Gaps = 9/115 (7%)

Query: 72  DMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQA 131
           D +  +E   R R+++  + + L E   Q E+Q   EQ R+R+R+   L     +  ++ 
Sbjct: 126 DRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ-RDRQRRDEELWRQRQEWQER- 183

Query: 132 DAAEARRA--GNLGKNPDVDTSFLPDRD--REEEENRLREELRQEWEAQREKVKD 182
              E RRA    L      +T   PD +  R  E   LR + R+E + QR + +D
Sbjct: 184 ---EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD 235



 Score = 29.3 bits (64), Expect = 5.0
 Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 11/104 (10%)

Query: 17   LLKKRERQ--REQMEVLKQRIAEETILKSQVDKRFSAHYDA-VEAELKSSTVGLVTLNDM 73
            L ++RE Q  R Q    K R  EE +   + ++R     D    AE + +T         
Sbjct: 1803 LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT-------QE 1855

Query: 74   KARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKI 117
            K+R+E     +E +  +RQ   E++L++E  R Q++  +R R++
Sbjct: 1856 KSRREEQELWQEEEQKRRQE-RERKLREEHIRRQQKEEQRHRQV 1898


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 50/184 (27%), Positives = 83/184 (45%), Gaps = 9/184 (4%)

Query: 5   KGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSST 64
           K   RE  R     ++RER+RE+    ++    E   + + DK+     D  +A  +   
Sbjct: 387 KSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRK- 445

Query: 65  VGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFAL 124
                L      +EA  +ER +    R+  + +  ++E +RE+E+RRE  ++   L   L
Sbjct: 446 -----LERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500

Query: 125 DDLDDQADAAEARRAGNLGKN-PDVDTSFLPD-RDREEEENRLREELRQEWEAQREKVKD 182
           +D DD  D  +  R   L K   D +     D RDR+ E+  L EE+RQ   A+     D
Sbjct: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEEL-EEIRQRLLAEGHPDPD 559

Query: 183 EEME 186
            E++
Sbjct: 560 AELQ 563



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 41/163 (25%), Positives = 75/163 (46%), Gaps = 4/163 (2%)

Query: 25  REQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEALVRER 84
           +E +  ++    +  ++  ++ K    H    E + K          + + R+    RER
Sbjct: 261 KEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERER 320

Query: 85  ERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLGK 144
           ER+  +R+   E+  ++E++RE+E+ R+R R     +   D   D+    +  R  +  +
Sbjct: 321 ERREREREREREREREKEKERERERERDRDRD---RTKERDRDRDRERDRDRDRERSSDR 377

Query: 145 NPDVDTSFLPDRDREEEENRLRE-ELRQEWEAQREKVKDEEME 186
           N D   S    RDRE E  R RE E  +E E +RE+ ++ E E
Sbjct: 378 NKDRSRSREKSRDRERERERERERERERERERERERERERERE 420



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 53/207 (25%), Positives = 95/207 (45%), Gaps = 35/207 (16%)

Query: 9   REAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLV 68
           RE  R     K+RER+RE     + R  + T    + D+      D      +SS     
Sbjct: 329 REREREREKEKERERERE-----RDRDRDRT---KERDRDRDRERDRDRDRERSSDRNK- 379

Query: 69  TLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLD 128
             +  ++R+++  RERER+  + +  E +R ++ER+RE+E+ RER+R+        D  +
Sbjct: 380 --DRSRSREKSRDRERERERERERERERER-ERERERERERERERERERE-KDKKRDREE 435

Query: 129 DQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWE-AQREKVKDEEMEV 187
           D+ DA E R+                +R   E+E   +E L+  WE  +R+K ++ E E 
Sbjct: 436 DEEDAYERRKL---------------ERKLREKEAAYQERLK-NWEIRERKKTREYEKEA 479

Query: 188 TFSYWDGSGHRRTVRVRKGNTVQQFLK 214
                +    RR    ++   +++FL+
Sbjct: 480 -----EREEERRREMAKEAKRLKEFLE 501



 Score = 32.3 bits (72), Expect = 0.59
 Identities = 26/94 (27%), Positives = 46/94 (48%), Gaps = 28/94 (29%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           + R+R++E++E ++QR+  E             H D  +AEL+            +  QE
Sbjct: 534 RDRKREKEELEEIRQRLLAE------------GHPDP-DAELQ------------RMEQE 568

Query: 79  ALVRERERQLAKRQHLEEQRLQQERQREQEQRRE 112
           A   ER RQ   +Q  E +  ++E+Q ++E+R E
Sbjct: 569 A---ERRRQPQIKQEPESEEEEEEKQEKEEKREE 599


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 58/243 (23%), Positives = 120/243 (49%), Gaps = 41/243 (16%)

Query: 19  KKRERQREQMEVLKQRIAEET----ILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMK 74
           ++ E  ++++E LK+R+ E T    ILK++++++ S        +  +S+  L  L +  
Sbjct: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS--------DGAASSYQLKQLEEQN 233

Query: 75  AR-QEALVRERERQLAKRQ-HLEEQRLQQERQREQE---QRRER-KRKISCLSFALDDLD 128
           AR ++ALVR R+   +++Q H++ Q+L +++ +E E   Q+RER + ++S     +D+L 
Sbjct: 234 ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELK 293

Query: 129 DQADAA-------EARRAGNLGKNPDV--------DTSFLPDRDREEEEN--RLREELRQ 171
           +Q DAA       E     NL     V        D   + + + E +EN      ELR+
Sbjct: 294 EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 353

Query: 172 EWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAG 231
           + +    +V++ +  V  +    + +++T++  +  T        LQ + ++    + A 
Sbjct: 354 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH------LQDVNRELTNQQEAS 407

Query: 232 VEQ 234
           VE+
Sbjct: 408 VER 410



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 33/139 (23%), Positives = 63/139 (45%), Gaps = 24/139 (17%)

Query: 50  SAHYDAVEAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQ----- 104
           S   + + A+++     L TL   +A  +A ++E E+   + + ++E + + + Q     
Sbjct: 80  SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139

Query: 105 -REQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEEN 163
            R +E R+E K  +      ++++ D ADA E                 +   D+E  E 
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIE-----------------MATLDKEMAEE 182

Query: 164 RLREELRQEWEAQREKVKD 182
           R  E L+QE EA +E+V +
Sbjct: 183 R-AESLQQEVEALKERVDE 200


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 58/243 (23%), Positives = 120/243 (49%), Gaps = 41/243 (16%)

Query: 19  KKRERQREQMEVLKQRIAEET----ILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMK 74
           ++ E  ++++E LK+R+ E T    ILK++++++ S        +  +S+  L  L +  
Sbjct: 296 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS--------DGAASSYQLKQLEEQN 347

Query: 75  AR-QEALVRERERQLAKRQ-HLEEQRLQQERQREQE---QRRER-KRKISCLSFALDDLD 128
           AR ++ALVR R+   +++Q H++ Q+L +++ +E E   Q+RER + ++S     +D+L 
Sbjct: 348 ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELK 407

Query: 129 DQADAA-------EARRAGNLGKNPDV--------DTSFLPDRDREEEEN--RLREELRQ 171
           +Q DAA       E     NL     V        D   + + + E +EN      ELR+
Sbjct: 408 EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 467

Query: 172 EWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAG 231
           + +    +V++ +  V  +    + +++T++  +  T        LQ + ++    + A 
Sbjct: 468 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH------LQDVNRELTNQQEAS 521

Query: 232 VEQ 234
           VE+
Sbjct: 522 VER 524



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 33/139 (23%), Positives = 63/139 (45%), Gaps = 24/139 (17%)

Query: 50  SAHYDAVEAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQ----- 104
           S   + + A+++     L TL   +A  +A ++E E+   + + ++E + + + Q     
Sbjct: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253

Query: 105 -REQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEEN 163
            R +E R+E K  +      ++++ D ADA E                 +   D+E  E 
Sbjct: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIE-----------------MATLDKEMAEE 296

Query: 164 RLREELRQEWEAQREKVKD 182
           R  E L+QE EA +E+V +
Sbjct: 297 R-AESLQQEVEALKERVDE 314


>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 58/243 (23%), Positives = 120/243 (49%), Gaps = 41/243 (16%)

Query: 19  KKRERQREQMEVLKQRIAEET----ILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMK 74
           ++ E  ++++E LK+R+ E T    ILK++++++ S        +  +S+  L  L +  
Sbjct: 182 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS--------DGAASSYQLKQLEEQN 233

Query: 75  AR-QEALVRERERQLAKRQ-HLEEQRLQQERQREQE---QRRER-KRKISCLSFALDDLD 128
           AR ++ALVR R+   +++Q H++ Q+L +++ +E E   Q+RER + ++S     +D+L 
Sbjct: 234 ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELK 293

Query: 129 DQADAA-------EARRAGNLGKNPDV--------DTSFLPDRDREEEEN--RLREELRQ 171
           +Q DAA       E     NL     V        D   + + + E +EN      ELR+
Sbjct: 294 EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 353

Query: 172 EWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAG 231
           + +    +V++ +  V  +    + +++T++  +  T        LQ + ++    + A 
Sbjct: 354 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH------LQDVNRELTNQQEAS 407

Query: 232 VEQ 234
           VE+
Sbjct: 408 VER 410



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 33/139 (23%), Positives = 63/139 (45%), Gaps = 24/139 (17%)

Query: 50  SAHYDAVEAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQ----- 104
           S   + + A+++     L TL   +A  +A ++E E+   + + ++E + + + Q     
Sbjct: 80  SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139

Query: 105 -REQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEEN 163
            R +E R+E K  +      ++++ D ADA E                 +   D+E  E 
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIE-----------------MATLDKEMAEE 182

Query: 164 RLREELRQEWEAQREKVKD 182
           R  E L+QE EA +E+V +
Sbjct: 183 R-AESLQQEVEALKERVDE 200


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 58/243 (23%), Positives = 120/243 (49%), Gaps = 41/243 (16%)

Query: 19  KKRERQREQMEVLKQRIAEET----ILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMK 74
           ++ E  ++++E LK+R+ E T    ILK++++++ S        +  +S+  L  L +  
Sbjct: 316 ERAESLQQEVEALKERVDELTTDLEILKAEIEEKGS--------DGAASSYQLKQLEEQN 367

Query: 75  AR-QEALVRERERQLAKRQ-HLEEQRLQQERQREQE---QRRER-KRKISCLSFALDDLD 128
           AR ++ALVR R+   +++Q H++ Q+L +++ +E E   Q+RER + ++S     +D+L 
Sbjct: 368 ARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELK 427

Query: 129 DQADAA-------EARRAGNLGKNPDV--------DTSFLPDRDREEEEN--RLREELRQ 171
           +Q DAA       E     NL     V        D   + + + E +EN      ELR+
Sbjct: 428 EQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELRE 487

Query: 172 EWEAQREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAG 231
           + +    +V++ +  V  +    + +++T++  +  T        LQ + ++    + A 
Sbjct: 488 QLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAH------LQDVNRELTNQQEAS 541

Query: 232 VEQ 234
           VE+
Sbjct: 542 VER 544



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 33/139 (23%), Positives = 63/139 (45%), Gaps = 24/139 (17%)

Query: 50  SAHYDAVEAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQ----- 104
           S   + + A+++     L TL   +A  +A ++E E+   + + ++E + + + Q     
Sbjct: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273

Query: 105 -REQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEEN 163
            R +E R+E K  +      ++++ D ADA E                 +   D+E  E 
Sbjct: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIE-----------------MATLDKEMAEE 316

Query: 164 RLREELRQEWEAQREKVKD 182
           R  E L+QE EA +E+V +
Sbjct: 317 R-AESLQQEVEALKERVDE 334


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 52.0 bits (123), Expect = 7e-07
 Identities = 36/113 (31%), Positives = 55/113 (48%), Gaps = 26/113 (23%)

Query: 74  KARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADA 133
           + R+    RER+R+  K + LE +R + ER+RE+E+ R+R+R          D D   D 
Sbjct: 687 RERERERERERDREREKERELERERAR-EREREREKERDRER----------DRDRDHDR 735

Query: 134 AEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
              R                 +RDRE+E  R REE  +E E +RE+ ++ E E
Sbjct: 736 ERERER---------------ERDREKEREREREERERERERERERERERERE 773



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 32/117 (27%), Positives = 57/117 (48%), Gaps = 1/117 (0%)

Query: 71  NDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLD-D 129
           ND   R E     R  ++  R+    +   +ER+R++E+ RER+R+         +L+ +
Sbjct: 651 NDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERE 710

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           +A   E  R     +  D D     +R+RE E +R +E  R+  E +RE+ ++ E E
Sbjct: 711 RAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERE 767



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 30/108 (27%), Positives = 55/108 (50%), Gaps = 9/108 (8%)

Query: 9   REAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLV 68
           RE  R     ++RER+RE+ E  ++R  E  + + +  +R        E E +       
Sbjct: 677 RERDRERERDRERERERER-ERDREREKERELERERARER--------EREREKERDRER 727

Query: 69  TLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRK 116
             +    R+    RER+R+  + +  EE+  ++ER+RE+E+ RER+R+
Sbjct: 728 DRDRDHDRERERERERDREKEREREREERERERERERERERERERERE 775



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 11/104 (10%)

Query: 84  RERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLG 143
           RER       +  Q    E +R++  RRE +R        +D +DD+ D     R     
Sbjct: 635 RERDQRPSSPIRHQGRNDELERDE--RREERR--------VDRVDDRRDERARERDRERE 684

Query: 144 KNPDVDTSFLPDRDRE-EEENRLREELRQEWEAQREKVKDEEME 186
           ++ + +     +RDRE E+E  L  E  +E E +REK +D E +
Sbjct: 685 RDRERERERERERDREREKERELERERAREREREREKERDRERD 728



 Score = 34.3 bits (77), Expect = 0.16
 Identities = 41/179 (22%), Positives = 75/179 (41%), Gaps = 5/179 (2%)

Query: 9   REAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLV 68
           RE  R     K+RER+RE+ E  ++R  E    + +  +R +   D      +       
Sbjct: 737 RERERERDREKEREREREERERERERERERERERERERER-ARERDKERERQRDWEDKDK 795

Query: 69  TLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLD 128
             +D + ++E +  +R  +    +   ++R + E      Q  +R+R+ S  S A +  D
Sbjct: 796 GRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGD 855

Query: 129 DQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEV 187
           D+    E  R  +    P    S  P    E+ + R +EE R+  E +    + EE E+
Sbjct: 856 DK---NEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKP-ERKESSRRYEEQEL 910



 Score = 31.6 bits (70), Expect = 1.0
 Identities = 29/108 (26%), Positives = 47/108 (43%), Gaps = 27/108 (25%)

Query: 81   VRERERQLAKRQHLEEQ-RLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRA 139
            V  R      R  L+E+ R + +R+RE+E+R  R+R          + D  AD    R  
Sbjct: 1286 VHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQR----------EWDRDADKDWPRNR 1335

Query: 140  GNLGKNPDVDTSFLPDRDREEEENRLRE-ELRQEWEAQREKVKDEEME 186
                           DRDR  E  R RE + R++ + +RE++  + +E
Sbjct: 1336 ---------------DRDRLRERERERERDKRRDLDRERERLISDSVE 1368



 Score = 28.9 bits (63), Expect = 6.5
 Identities = 27/102 (26%), Positives = 47/102 (46%), Gaps = 10/102 (9%)

Query: 83  ERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLD--------DQADAA 134
           ER  Q   R+H   +  + +R RE++ R ER+ +    S + D  D        D+ DA 
Sbjct: 404 ERTSQSHDRRHERREDTRGKRDREKDSREEREYE-QDQSSSRDHRDDREPRDGRDRRDAR 462

Query: 135 EARRAGNLGKNPDV-DTSFLPDRDREEEENRLREELRQEWEA 175
           + R    L  + D+ D+  + D  R+ +E+R   + R   +A
Sbjct: 463 DTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDA 504


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 39/170 (22%), Positives = 83/170 (48%), Gaps = 17/170 (10%)

Query: 18  LKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQ 77
           +++ +++R + E  +    E   +K++ DK+ +     +EAE K++          + R+
Sbjct: 257 MEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA-------QERERR 309

Query: 78  EALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDL-DDQADAAEA 136
           EA  RER R+  KR   E QR+++E +R  E+R+  K +    +     + +++  AAE 
Sbjct: 310 EAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 369

Query: 137 RRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           R+     +          ++ + EE+ R ++   ++   Q  K+K E++E
Sbjct: 370 RQRARAEEE---------EKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 41/168 (24%), Positives = 75/168 (44%), Gaps = 16/168 (9%)

Query: 20  KRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEA 79
           +  R+R + E L+Q+  EE++ +       +A     + E K++T    T   ++   EA
Sbjct: 39  RERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTT----TNTQVEGDDEA 94

Query: 80  LVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRA 139
              ER   LA+R+   ++RLQ+  +R+    +E    I+  S +L     Q D AE    
Sbjct: 95  AFLER---LARREERRQKRLQEALERQ----KEFDPTITDASLSLPSRRMQNDTAENETT 147

Query: 140 GNLGKNPDVDTSFLPDRDREEEENRLREELRQEW-EAQREKVKDEEME 186
               K+      +    + EE E   +   + +W +A+  K +D+E E
Sbjct: 148 EKEEKSESRQERY----EIEETETVTKSYQKNDWRDAEENKKEDKEKE 191



 Score = 36.6 bits (83), Expect = 0.031
 Identities = 35/180 (19%), Positives = 81/180 (45%), Gaps = 12/180 (6%)

Query: 10  EAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVT 69
           E   A    ++   +RE+M   ++R AEE     + +KR +     ++ E K +      
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA---EE 355

Query: 70  LNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
              +K  ++    ER+R  A+    EE++ + E Q+  +Q  E+K  +       + ++ 
Sbjct: 356 RQRIKEEEKRAAEERQRARAE----EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQ 411

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREE--EENRLREELRQEWEA-QREKVKDEEME 186
           + +           +   + T+ L  +  E+  +    RE+L+++    ++E++KDE+++
Sbjct: 412 KIEGKWVNE--KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 469



 Score = 34.3 bits (77), Expect = 0.16
 Identities = 36/166 (21%), Positives = 71/166 (42%), Gaps = 19/166 (11%)

Query: 23  RQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEALVR 82
           +Q E+ E     I+    ++ +  +R  A    +EAE                 +E +  
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE----------------ERERIKA 282

Query: 83  ERERQLA-KRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGN 141
           E+++++A +R  +E +     ++RE+ +  ER+R       A ++   +    E R A  
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEE-RQRIKEEEKRAAEE 341

Query: 142 LGKNPDVDTSFLPDRDR-EEEENRLREELRQEWEAQREKVKDEEME 186
             +  + +     +R R +EEE R  EE ++    + EK K EE +
Sbjct: 342 RQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQK 387



 Score = 31.6 bits (70), Expect = 1.0
 Identities = 27/120 (22%), Positives = 54/120 (45%), Gaps = 15/120 (12%)

Query: 70  LNDMKARQEALVRERERQLAKRQHL--------EEQRLQQERQREQEQRRERKRKISCLS 121
           ++D + R+E   ++RE    + + +        EE+  ++ R+R +++R  +K++   L 
Sbjct: 1   MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60

Query: 122 FALDDLDDQA-----DAAEARRAGNLGKNPDVDTSFLPDRDREEE--ENRLREELRQEWE 174
              D ++  A     D        N     D + +FL    R EE  + RL+E L ++ E
Sbjct: 61  QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120



 Score = 28.9 bits (63), Expect = 6.5
 Identities = 44/185 (23%), Positives = 76/185 (41%), Gaps = 46/185 (24%)

Query: 18  LKKRERQREQMEVLKQRIAEETILKSQ-----------VDKRFS-----AHYDAVEAELK 61
           +KK +  +E+++    R    T +KSQ            +  FS     A  D  EAE  
Sbjct: 468 IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGA 527

Query: 62  SSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLS 121
                   L +++ R+     E   +L ++Q  +E  L+ E   E +++RE +RK+    
Sbjct: 528 PQVEAGKRLEELRRRRGETESEEFEKLKQKQ--QEAALELE---ELKKKREERRKV---- 578

Query: 122 FALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREEL---RQEWEAQRE 178
                     +  E RR     K  + D         EEE+ RL+EE+   R E   +R+
Sbjct: 579 ---------LEEEEQRR-----KQEEADRKLR----EEEEKRRLKEEIERRRAEAAEKRQ 620

Query: 179 KVKDE 183
           K+ ++
Sbjct: 621 KMPED 625


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 38/138 (27%), Positives = 65/138 (47%), Gaps = 23/138 (16%)

Query: 74  KARQEALVRERERQLAKRQHLEEQR-----LQQERQREQEQRRERKRKISCLSFALDDLD 128
           + R+    RERER+  +++  E +R      Q+E +R++E+ RERKRK            
Sbjct: 299 RKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRK----------RQ 348

Query: 129 DQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME-V 187
            + D    R+ G  G+          +R+RE E  R R+  R+  E +R++ +D + E  
Sbjct: 349 TEMDRERNRQTGREGRRQ-------AERERERERERDRQSAREREERERDRDRDRQKERE 401

Query: 188 TFSYWDGSGHRRTVRVRK 205
             +  D  G R T + R+
Sbjct: 402 RQTEKDRDGQRETEKQRE 419



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 56/204 (27%), Positives = 86/204 (42%), Gaps = 28/204 (13%)

Query: 7   TMREAGRAMHLLKKRERQRE-------QMEVLKQRIAEETILKSQVDKRFSAHYDAVEAE 59
           T RE  R     ++RE+Q E       + E  K+R  E    + + D+R        + +
Sbjct: 228 TDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDR-DRRQKERERQTDRK 286

Query: 60  LKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQR---LQQERQREQEQRRERKRK 116
            +  T         + RQ    RERER   + +  E +R    Q+E +R++E+ RERKRK
Sbjct: 287 RQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRK 346

Query: 117 ISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEE-----NRLREELRQ 171
                  +D   ++    E RR     +  + +      R+REE E     +R +E  RQ
Sbjct: 347 RQT---EMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQ 403

Query: 172 ---------EWEAQREKVKDEEME 186
                    E E QRE+ KD E E
Sbjct: 404 TEKDRDGQRETEKQREREKDRESE 427



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 47/183 (25%), Positives = 82/183 (44%), Gaps = 13/183 (7%)

Query: 9   REAGRAMHLLKKRERQRE-QMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGL 67
           RE  R     + RERQR+ + E  +Q   E    + +   R        E E +      
Sbjct: 83  REKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQ 142

Query: 68  VTLNDMKARQEALVRERERQL-AKRQHLEEQRLQQERQRE--QEQRRERKRKISCLSFAL 124
                 + RQ    +ERERQ   +RQ   E+  Q+ER+RE  +++RRER+R+        
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQ-------- 194

Query: 125 DDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLRE-ELRQEWEAQREKVKDE 183
            + +++ +   + R     +  + +T     R  + E +R R+ E  +E +A+RE+  + 
Sbjct: 195 REKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASER 254

Query: 184 EME 186
           E E
Sbjct: 255 ETE 257



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 49/194 (25%), Positives = 76/194 (39%), Gaps = 48/194 (24%)

Query: 9   REAGRAMHLLKKRERQREQMEVLKQRIAE-------------ETILKSQVDKRFSAHYDA 55
           RE  +     ++RERQRE+    + R +E             ET  K Q D+        
Sbjct: 179 REREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238

Query: 56  VEAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKR 115
                K +            R+ A  RE ER   + +  +  R +  RQ+E+E++ +RKR
Sbjct: 239 EREREKQAE-----------RERASERETERDKERERERDRDRDRDRRQKERERQTDRKR 287

Query: 116 KISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLRE---ELRQE 172
           +         + D + +    R+                +R+RE E NR RE   E  +E
Sbjct: 288 Q------RRTERDRETERKRERQR---------------ERERERERNRKRERERERERE 326

Query: 173 WEAQREKVKDEEME 186
            E QRE  +D E E
Sbjct: 327 RERQRETERDREKE 340



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 33/115 (28%), Positives = 56/115 (48%), Gaps = 4/115 (3%)

Query: 76  RQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAE 135
           R+    +ERER+  KRQ   E   ++ER+RE+++ R+R R          + + Q D   
Sbjct: 54  RERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRER 113

Query: 136 AR---RAGNLGKNPDVDTSFLPDRDREEEENRLREELRQ-EWEAQREKVKDEEME 186
            R   +  N  K  + +T    +R R+ + +  RE  RQ + E +RE+  D E +
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQ 168



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 20/164 (12%)

Query: 9   REAGRAMHLLKKRERQRE-QMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGL 67
           RE  R     +KRER+RE + E  +QR  E    K +  KR        E   ++   G 
Sbjct: 305 RERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREG- 363

Query: 68  VTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDL 127
                   R+    RER+RQ A+      +R ++ER R++++++ER+R+         D 
Sbjct: 364 ---RRQAERERERERERDRQSAR------EREERERDRDRDRQKERERQTE------KDR 408

Query: 128 DDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQ 171
           D Q +  + R      K+ + +      R+RE+++ R R+  RQ
Sbjct: 409 DGQRETEKQRER---EKDRESERGRERGREREKQKGRERDRERQ 449



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 32/113 (28%), Positives = 58/113 (51%), Gaps = 12/113 (10%)

Query: 74  KARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADA 133
           +A ++A   +RER   K +  E +R +++ +RE +++RER+R+         D   + D 
Sbjct: 44  QAHKDADGDDRERNRQKER--ERRREKRQTERETDRKRERRRE--------KDRHRKRDR 93

Query: 134 AEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
              R+  +  K  +  T    DR RE+E NR +E  R E E + E+ +D + +
Sbjct: 94  HRERQR-DREKERERQTDRERDRQREKERNRQKERER-ETEREGERGRDRQTD 144



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 11/123 (8%)

Query: 72  DMKARQEALV------RERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALD 125
           + + R+E         R+RER+  K +H +  R  +ERQR++E+ RER+           
Sbjct: 61  ERERRREKRQTERETDRKRERRREKDRHRKRDR-HRERQRDREKERERQTDRERDRQREK 119

Query: 126 DLDDQAD-AAEARRAGNLGKNPDVDTSFLPDRDREEEENRLRE---ELRQEWEAQREKVK 181
           + + Q +   E  R G  G++   D     +R R+ E+ R R+   E +++ E  R+K +
Sbjct: 120 ERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKER 179

Query: 182 DEE 184
           + E
Sbjct: 180 ERE 182



 Score = 29.6 bits (65), Expect = 3.8
 Identities = 24/114 (21%), Positives = 53/114 (46%), Gaps = 9/114 (7%)

Query: 7   TMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVG 66
           T RE  R     ++RER+R++    ++   E    + +  +R        E + +    G
Sbjct: 359 TGREGRRQAERERERERERDRQSAREREERERDRDRDRQKER--------ERQTEKDRDG 410

Query: 67  LVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL 120
                  + R++    ER R+  + +  ++ R +++R+R+ +++  R+RK S L
Sbjct: 411 QRETEKQREREKDRESERGRERGREREKQKGR-ERDRERQTDRQAGRQRKRSTL 463



 Score = 28.5 bits (62), Expect = 8.5
 Identities = 27/107 (25%), Positives = 43/107 (40%), Gaps = 3/107 (2%)

Query: 9   REAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLV 68
           R+ GR      +RER+RE+    +     E   + +   R        E +         
Sbjct: 357 RQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEK 416

Query: 69  TLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKR 115
                K R+    RER R+  K++  E  R   ERQ +++  R+RKR
Sbjct: 417 QREREKDRESERGRERGREREKQKGRERDR---ERQTDRQAGRQRKR 460


>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
          Length = 675

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 44/205 (21%), Positives = 97/205 (47%), Gaps = 16/205 (7%)

Query: 6   GTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTV 65
           GT++     M   ++ E+++   E  K+RI ++ + K ++ +  +   + +E    + T 
Sbjct: 100 GTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTE 159

Query: 66  G---------LVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQRE--QEQRRERK 114
                     L+T+  +K+ + +   ++  +  +++  E++R++ E  +    E++R   
Sbjct: 160 SASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSL 219

Query: 115 RKISCLSFALDDLDDQADAAEARRAGNLGKN-PDVDTSFLPDRDREEEE---NRLREELR 170
           ++  CLS  +DD  +     E+   G L     +++     +R ++ EE    RL EE R
Sbjct: 220 KEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKR 279

Query: 171 QEWEAQREKV-KDEEMEVTFSYWDG 194
              EA+R+ V +DEE + T   + G
Sbjct: 280 AFEEARRQMVNEDEENQDTAKIFKG 304



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 32/115 (27%), Positives = 59/115 (51%), Gaps = 9/115 (7%)

Query: 72  DMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQA 131
           D+K + EA+ R RE +  +R   E+QR +++  RE+E  R RK++I  +  A DD +D +
Sbjct: 30  DVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNR-RKQEIKEM-LASDDEEDVS 87

Query: 132 DAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
              E      L       T  +  R  E E+ R  E+ ++  E ++ +++ + +E
Sbjct: 88  SKVEKAYVPKL-------TGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLE 135



 Score = 34.3 bits (77), Expect = 0.16
 Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 4/101 (3%)

Query: 18  LKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQ 77
           L ++E Q++  E   +R A +  +K +  + F    D      + S        +MKAR 
Sbjct: 458 LSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARF 517

Query: 78  EALVRERERQLAKRQHLEEQRL--QQERQREQEQRRERKRK 116
           E + + RE +  +++ +EEQ+L   Q  QRE +   ++KR+
Sbjct: 518 EQMAKAREEE--EQRRIEEQKLLRMQFEQREIDAALQKKRE 556



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 34/172 (19%), Positives = 76/172 (44%), Gaps = 10/172 (5%)

Query: 22  ERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEALV 81
           E +R++ E  K++  EE   + + +KR  A  +A    +        T    K  +   +
Sbjct: 253 ELERQRQENRKKQAEEEARKRLEEEKR--AFEEARRQMVNEDEENQDTAKIFKGYRPGKL 310

Query: 82  RERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGN 141
           +    ++ +++  +E+R  +E  R + +  ++    +  +  +DD   +     ++    
Sbjct: 311 KLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLT 370

Query: 142 LGKNPDVDTSFLPDRDREEEENRLREELR-------QEWEAQREKVKDEEME 186
            GK  +++   L  +  EEE+ R  EE +       QE+E  R+++ +EE E
Sbjct: 371 PGKL-EINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEE 421


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 47/180 (26%), Positives = 87/180 (48%), Gaps = 38/180 (21%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           K+ E +R++ E L+++  +E IL+ Q ++      +   A  K              ++E
Sbjct: 743 KREEEERKRQEELRRQ--QEEILRRQQEEERKRREEEELARRK--------------QEE 786

Query: 79  ALVRERERQLA-KRQHLEEQRLQQ--------ERQREQEQRRE-----RKRKISCLSFAL 124
           AL R+RE+++A +RQ  EE+R QQ        ER+RE+E+RR+     RK++     +A 
Sbjct: 787 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAR 846

Query: 125 DDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEE 184
           ++ + Q    E R          ++      R  EEE  R   E++++ E  R++ + +E
Sbjct: 847 EEEEAQRRLEENRLR--------MEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE 898



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 35/117 (29%), Positives = 62/117 (52%), Gaps = 7/117 (5%)

Query: 72  DMKARQEALVRERERQLAKRQH--LEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
           +M+A++E   R+R+ +L ++Q   L  Q+ ++ ++RE+E+   RK++      AL    +
Sbjct: 739 EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE-----EALRRQRE 793

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           Q  A   +R     +  +     L +R REEEE R +EEL ++ E +  K   EE E
Sbjct: 794 QEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE 850



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 42/177 (23%), Positives = 80/177 (45%), Gaps = 20/177 (11%)

Query: 10   EAGRAMHLLKKRERQ----REQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTV 65
            EA R  H  ++R+R+    + Q E+++QR  ++  L+    ++        + +L SS+ 
Sbjct: 865  EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQ--QQQQLAQMKLPSSST 922

Query: 66   GLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALD 125
                 N    + +A +      LA+ Q LEE+R   ERQ  +EQRR+++  +  L     
Sbjct: 923  WGQQSNTTACQSQATL-----SLAEIQKLEEER---ERQLREEQRRQQRELMKAL----- 969

Query: 126  DLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKD 182
                Q    +    GN+ K P   T  L +  +EE     +++ +Q+   Q  + ++
Sbjct: 970  QQQQQQQQQKLSGWGNVSK-PSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARN 1025



 Score = 36.6 bits (83), Expect = 0.031
 Identities = 35/172 (20%), Positives = 77/172 (44%), Gaps = 16/172 (9%)

Query: 10  EAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVT 69
           EA R +   ++ E +R + E L ++  EE    ++ ++      +     ++     L  
Sbjct: 812 EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH 871

Query: 70  LNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
             + + R+E  V+ ++  + +RQ  +E   + ++Q++Q+Q  + K      S +      
Sbjct: 872 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP----SSSTWGQQS 927

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVK 181
              A +++   +L +   ++         EE E +LREE R++   QRE +K
Sbjct: 928 NTTACQSQATLSLAEIQKLE---------EERERQLREEQRRQ---QRELMK 967



 Score = 33.1 bits (74), Expect = 0.35
 Identities = 44/180 (24%), Positives = 78/180 (43%), Gaps = 21/180 (11%)

Query: 26  EQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLN---------DMKAR 76
           +Q + LK RI+++ I+ S V +  S        EL+ +                 D    
Sbjct: 655 QQFQTLKMRISDQNIIPS-VTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP 713

Query: 77  QEALVRERERQLAKRQHLEEQRLQQERQ--REQEQRRE----RKRKISCLSFALDDLDDQ 130
             AL + ++ + AK   LE++R + E +  RE+E+R+     R+++   L    ++   +
Sbjct: 714 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 773

Query: 131 ADAAE-ARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQR----EKVKDEEM 185
            +  E ARR          +      R REEEE + +EE  +  E +R    E+ K EE+
Sbjct: 774 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 833


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 47/180 (26%), Positives = 87/180 (48%), Gaps = 38/180 (21%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           K+ E +R++ E L+++  +E IL+ Q ++      +   A  K              ++E
Sbjct: 770 KREEEERKRQEELRRQ--QEEILRRQQEEERKRREEEELARRK--------------QEE 813

Query: 79  ALVRERERQLA-KRQHLEEQRLQQ--------ERQREQEQRRE-----RKRKISCLSFAL 124
           AL R+RE+++A +RQ  EE+R QQ        ER+RE+E+RR+     RK++     +A 
Sbjct: 814 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAR 873

Query: 125 DDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEE 184
           ++ + Q    E R          ++      R  EEE  R   E++++ E  R++ + +E
Sbjct: 874 EEEEAQRRLEENRLR--------MEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE 925



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 35/117 (29%), Positives = 62/117 (52%), Gaps = 7/117 (5%)

Query: 72  DMKARQEALVRERERQLAKRQH--LEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
           +M+A++E   R+R+ +L ++Q   L  Q+ ++ ++RE+E+   RK++      AL    +
Sbjct: 766 EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE-----EALRRQRE 820

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           Q  A   +R     +  +     L +R REEEE R +EEL ++ E +  K   EE E
Sbjct: 821 QEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE 877



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 42/177 (23%), Positives = 80/177 (45%), Gaps = 20/177 (11%)

Query: 10   EAGRAMHLLKKRERQ----REQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTV 65
            EA R  H  ++R+R+    + Q E+++QR  ++  L+    ++        + +L SS+ 
Sbjct: 892  EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQ--QQQQLAQMKLPSSST 949

Query: 66   GLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALD 125
                 N    + +A +      LA+ Q LEE+R   ERQ  +EQRR+++  +  L     
Sbjct: 950  WGQQSNTTACQSQATL-----SLAEIQKLEEER---ERQLREEQRRQQRELMKAL----- 996

Query: 126  DLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKD 182
                Q    +    GN+ K P   T  L +  +EE     +++ +Q+   Q  + ++
Sbjct: 997  QQQQQQQQQKLSGWGNVSK-PSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARN 1052



 Score = 36.6 bits (83), Expect = 0.031
 Identities = 35/172 (20%), Positives = 77/172 (44%), Gaps = 16/172 (9%)

Query: 10  EAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVT 69
           EA R +   ++ E +R + E L ++  EE    ++ ++      +     ++     L  
Sbjct: 839 EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH 898

Query: 70  LNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
             + + R+E  V+ ++  + +RQ  +E   + ++Q++Q+Q  + K      S +      
Sbjct: 899 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP----SSSTWGQQS 954

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVK 181
              A +++   +L +   ++         EE E +LREE R++   QRE +K
Sbjct: 955 NTTACQSQATLSLAEIQKLE---------EERERQLREEQRRQ---QRELMK 994



 Score = 33.1 bits (74), Expect = 0.35
 Identities = 44/180 (24%), Positives = 78/180 (43%), Gaps = 21/180 (11%)

Query: 26  EQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLN---------DMKAR 76
           +Q + LK RI+++ I+ S V +  S        EL+ +                 D    
Sbjct: 682 QQFQTLKMRISDQNIIPS-VTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP 740

Query: 77  QEALVRERERQLAKRQHLEEQRLQQERQ--REQEQRRE----RKRKISCLSFALDDLDDQ 130
             AL + ++ + AK   LE++R + E +  RE+E+R+     R+++   L    ++   +
Sbjct: 741 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 800

Query: 131 ADAAE-ARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQR----EKVKDEEM 185
            +  E ARR          +      R REEEE + +EE  +  E +R    E+ K EE+
Sbjct: 801 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 860


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 47/180 (26%), Positives = 87/180 (48%), Gaps = 38/180 (21%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           K+ E +R++ E L+++  +E IL+ Q ++      +   A  K              ++E
Sbjct: 749 KREEEERKRQEELRRQ--QEEILRRQQEEERKRREEEELARRK--------------QEE 792

Query: 79  ALVRERERQLA-KRQHLEEQRLQQ--------ERQREQEQRRE-----RKRKISCLSFAL 124
           AL R+RE+++A +RQ  EE+R QQ        ER+RE+E+RR+     RK++     +A 
Sbjct: 793 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAR 852

Query: 125 DDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEE 184
           ++ + Q    E R          ++      R  EEE  R   E++++ E  R++ + +E
Sbjct: 853 EEEEAQRRLEENRLR--------MEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE 904



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 35/117 (29%), Positives = 62/117 (52%), Gaps = 7/117 (5%)

Query: 72  DMKARQEALVRERERQLAKRQH--LEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
           +M+A++E   R+R+ +L ++Q   L  Q+ ++ ++RE+E+   RK++      AL    +
Sbjct: 745 EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE-----EALRRQRE 799

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           Q  A   +R     +  +     L +R REEEE R +EEL ++ E +  K   EE E
Sbjct: 800 QEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE 856



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 42/177 (23%), Positives = 80/177 (45%), Gaps = 20/177 (11%)

Query: 10   EAGRAMHLLKKRERQ----REQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTV 65
            EA R  H  ++R+R+    + Q E+++QR  ++  L+    ++        + +L SS+ 
Sbjct: 871  EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQ--QQQQLAQMKLPSSST 928

Query: 66   GLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALD 125
                 N    + +A +      LA+ Q LEE+R   ERQ  +EQRR+++  +  L     
Sbjct: 929  WGQQSNTTACQSQATL-----SLAEIQKLEEER---ERQLREEQRRQQRELMKAL----- 975

Query: 126  DLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKD 182
                Q    +    GN+ K P   T  L +  +EE     +++ +Q+   Q  + ++
Sbjct: 976  QQQQQQQQQKLSGWGNVSK-PSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARN 1031



 Score = 36.6 bits (83), Expect = 0.031
 Identities = 35/172 (20%), Positives = 77/172 (44%), Gaps = 16/172 (9%)

Query: 10  EAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVT 69
           EA R +   ++ E +R + E L ++  EE    ++ ++      +     ++     L  
Sbjct: 818 EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH 877

Query: 70  LNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
             + + R+E  V+ ++  + +RQ  +E   + ++Q++Q+Q  + K      S +      
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP----SSSTWGQQS 933

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVK 181
              A +++   +L +   ++         EE E +LREE R++   QRE +K
Sbjct: 934 NTTACQSQATLSLAEIQKLE---------EERERQLREEQRRQ---QRELMK 973



 Score = 33.1 bits (74), Expect = 0.35
 Identities = 44/180 (24%), Positives = 78/180 (43%), Gaps = 21/180 (11%)

Query: 26  EQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLN---------DMKAR 76
           +Q + LK RI+++ I+ S V +  S        EL+ +                 D    
Sbjct: 661 QQFQTLKMRISDQNIIPS-VTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP 719

Query: 77  QEALVRERERQLAKRQHLEEQRLQQERQ--REQEQRRE----RKRKISCLSFALDDLDDQ 130
             AL + ++ + AK   LE++R + E +  RE+E+R+     R+++   L    ++   +
Sbjct: 720 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 779

Query: 131 ADAAE-ARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQR----EKVKDEEM 185
            +  E ARR          +      R REEEE + +EE  +  E +R    E+ K EE+
Sbjct: 780 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 839


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 47/180 (26%), Positives = 87/180 (48%), Gaps = 38/180 (21%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           K+ E +R++ E L+++  +E IL+ Q ++      +   A  K              ++E
Sbjct: 749 KREEEERKRQEELRRQ--QEEILRRQQEEERKRREEEELARRK--------------QEE 792

Query: 79  ALVRERERQLA-KRQHLEEQRLQQ--------ERQREQEQRRE-----RKRKISCLSFAL 124
           AL R+RE+++A +RQ  EE+R QQ        ER+RE+E+RR+     RK++     +A 
Sbjct: 793 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAR 852

Query: 125 DDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEE 184
           ++ + Q    E R          ++      R  EEE  R   E++++ E  R++ + +E
Sbjct: 853 EEEEAQRRLEENRLR--------MEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQE 904



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 35/117 (29%), Positives = 62/117 (52%), Gaps = 7/117 (5%)

Query: 72  DMKARQEALVRERERQLAKRQH--LEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
           +M+A++E   R+R+ +L ++Q   L  Q+ ++ ++RE+E+   RK++      AL    +
Sbjct: 745 EMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE-----EALRRQRE 799

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           Q  A   +R     +  +     L +R REEEE R +EEL ++ E +  K   EE E
Sbjct: 800 QEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEE 856



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 42/177 (23%), Positives = 80/177 (45%), Gaps = 20/177 (11%)

Query: 10   EAGRAMHLLKKRERQ----REQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTV 65
            EA R  H  ++R+R+    + Q E+++QR  ++  L+    ++        + +L SS+ 
Sbjct: 871  EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQ--QQQQLAQMKLPSSST 928

Query: 66   GLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALD 125
                 N    + +A +      LA+ Q LEE+R   ERQ  +EQRR+++  +  L     
Sbjct: 929  WGQQSNTTACQSQATL-----SLAEIQKLEEER---ERQLREEQRRQQRELMKAL----- 975

Query: 126  DLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKD 182
                Q    +    GN+ K P   T  L +  +EE     +++ +Q+   Q  + ++
Sbjct: 976  QQQQQQQQQKLSGWGNVSK-PSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARN 1031



 Score = 36.6 bits (83), Expect = 0.031
 Identities = 35/172 (20%), Positives = 77/172 (44%), Gaps = 16/172 (9%)

Query: 10  EAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVT 69
           EA R +   ++ E +R + E L ++  EE    ++ ++      +     ++     L  
Sbjct: 818 EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRH 877

Query: 70  LNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDD 129
             + + R+E  V+ ++  + +RQ  +E   + ++Q++Q+Q  + K      S +      
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP----SSSTWGQQS 933

Query: 130 QADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVK 181
              A +++   +L +   ++         EE E +LREE R++   QRE +K
Sbjct: 934 NTTACQSQATLSLAEIQKLE---------EERERQLREEQRRQ---QRELMK 973



 Score = 33.1 bits (74), Expect = 0.35
 Identities = 44/180 (24%), Positives = 78/180 (43%), Gaps = 21/180 (11%)

Query: 26  EQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLN---------DMKAR 76
           +Q + LK RI+++ I+ S V +  S        EL+ +                 D    
Sbjct: 661 QQFQTLKMRISDQNIIPS-VTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP 719

Query: 77  QEALVRERERQLAKRQHLEEQRLQQERQ--REQEQRRE----RKRKISCLSFALDDLDDQ 130
             AL + ++ + AK   LE++R + E +  RE+E+R+     R+++   L    ++   +
Sbjct: 720 GPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 779

Query: 131 ADAAE-ARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQR----EKVKDEEM 185
            +  E ARR          +      R REEEE + +EE  +  E +R    E+ K EE+
Sbjct: 780 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 839


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 43/181 (23%), Positives = 91/181 (50%), Gaps = 15/181 (8%)

Query: 8   MREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGL 67
           +RE    MH   ++E+ REQ E   +R  EE I + +  +   A     E +++     +
Sbjct: 346 IRELEEKMH---EQEKIREQEE---KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399

Query: 68  VTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQR-RERKRKISCLSFALDD 126
               +M   QE  + E+E ++ +++  EE + Q+E+ R QE++ RE+++KI      + +
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQE--EEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457

Query: 127 LDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWE---AQREKVKDE 183
            ++     E +     GK  + +      +++EE+  R  E++R++ +    Q EK++++
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKM---QEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514

Query: 184 E 184
           E
Sbjct: 515 E 515



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 40/182 (21%), Positives = 86/182 (47%), Gaps = 14/182 (7%)

Query: 18  LKKRERQREQMEV--LKQRIAEETILKSQVDKRFSAHY-----DAVEAELKSSTVGLVTL 70
           L + E+   Q+ V  LK+++    +L  Q   +  A +      +V A+L++        
Sbjct: 220 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 279

Query: 71  NDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQ 130
           N +  +QE  +  +E ++ +R+  E+ + Q+E+ REQE++  R+ ++           ++
Sbjct: 280 NRLNQQQEEKMWRQEEKIQERE--EKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 337

Query: 131 ADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLRE-ELRQEWEA----QREKVKDEEM 185
               +  +   L +            ++ +EE ++RE E RQE EA    Q EK++++E 
Sbjct: 338 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 397

Query: 186 EV 187
           ++
Sbjct: 398 KI 399



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 40/168 (23%), Positives = 77/168 (45%), Gaps = 25/168 (14%)

Query: 19  KKRERQREQMEVLKQRIAE-ETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQ 77
           +K  RQ E+++  +++I E E  ++ Q +K         E E K              RQ
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMR------------RQ 335

Query: 78  EALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEAR 137
           E ++ E+E ++   + LEE+  +QE+ REQE++R+ + KI           ++    EA+
Sbjct: 336 EEMMWEKEEKI---RELEEKMHEQEKIREQEEKRQEEEKIR--------EQEKRQEQEAK 384

Query: 138 RAGNLGKNPDVDTSFLPDRD-REEEENRLREELRQEWEAQREKVKDEE 184
                 K  + +       +  +E+E ++ E+  + WE + E  + EE
Sbjct: 385 MWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEE 432



 Score = 36.2 bits (82), Expect = 0.041
 Identities = 36/191 (18%), Positives = 88/191 (46%), Gaps = 3/191 (1%)

Query: 5   KGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKR--FSAHYDAVEAELKS 62
           K   R+  RA  LL +++ Q E   + K+  +    L++QV++   ++      E ++  
Sbjct: 233 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWR 292

Query: 63  STVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSF 122
               +    +    QE  +RE+E ++ +++ +  ++ +++ +R++E   E++ KI  L  
Sbjct: 293 QEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEK-EEKMRRQEEMMWEKEEKIRELEE 351

Query: 123 ALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKD 182
            + + +   +  E R+     +  +          R+EE+ R +EE  +E E   ++ ++
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEE 411

Query: 183 EEMEVTFSYWD 193
           +  E     W+
Sbjct: 412 KMGEQEEKMWE 422



 Score = 36.2 bits (82), Expect = 0.041
 Identities = 36/207 (17%), Positives = 94/207 (45%), Gaps = 28/207 (13%)

Query: 3   QYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAV---EAE 59
           Q +  +RE  +      K  RQ E++   +++I E+  +  + +++     + +   E E
Sbjct: 367 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE 426

Query: 60  LKSSTVGLVTLNDMKARQEALVRERERQLAKRQHL---EEQRL----------------Q 100
           ++     +    +    QE  +RE+E ++ +++ +   +E+++                Q
Sbjct: 427 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ 486

Query: 101 QERQREQEQR-RERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDRE 159
           +E+ R QE++ RE+++KI      + + ++     E +      K  + +     ++ +E
Sbjct: 487 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE-----EKMQE 541

Query: 160 EEENRLREELRQEWEAQREKVKDEEME 186
           +EE   R+E +   +  R + ++E+M+
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQ 568


>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 202

 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 7/114 (6%)

Query: 76  RQEALVRERERQLAK---RQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQAD 132
           RQ    +ERERQ  +   RQ   E   + ERQRE++++RERKR+         D + + +
Sbjct: 48  RQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRE 107

Query: 133 AAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
               R     G   + D     +RDRE E  R RE  RQ    QRE+ ++ + E
Sbjct: 108 TDRNRERNRKG-GRERDKQTERERDRERERQRQRERERQR---QRERKRETDRE 157



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 32/117 (27%), Positives = 56/117 (47%), Gaps = 8/117 (6%)

Query: 74  KARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADA 133
           + R+     ERE +  +R    E+  Q +R++E+E+++ER R+         + + Q + 
Sbjct: 23  RQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETERQRER 82

Query: 134 AEAR-RAGNLGKNPDVDTSFLPDRDREEEENRLREELR---QEWEAQREKVKDEEME 186
              R R     +  D D     DR+R+ E +R RE  R   +E + Q E+ +D E E
Sbjct: 83  QRQRERKRQTDRERDKDR----DRERKRETDRNRERNRKGGRERDKQTERERDRERE 135



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 41/191 (21%), Positives = 80/191 (41%), Gaps = 16/191 (8%)

Query: 1   MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL 60
           M + +   RE  R     ++R+RQRE+          +T  +++  +R        + + 
Sbjct: 1   MERQRERKRETDRGKETERERDRQRER--------ENQTERENRHRQRDRHRERDRQTDR 52

Query: 61  KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL 120
           +         +  + R+    RE ERQ  +RQ   E++ Q +R+R++++ RERKR+    
Sbjct: 53  EKERERQKERDRQRQRERETERETERQ-RERQRQRERKRQTDRERDKDRDRERKRETDRN 111

Query: 121 -------SFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEW 173
                      D   ++    E  R     +          + DRE +    REE ++E 
Sbjct: 112 RERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKER 171

Query: 174 EAQREKVKDEE 184
           + +R+K + E+
Sbjct: 172 KKERKKERKEK 182



 Score = 33.5 bits (75), Expect = 0.26
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 16/110 (14%)

Query: 82  RERERQLAKRQHLEEQRLQQERQREQEQR--RERKRKISCLSFALDDLDDQADAAEARRA 139
           RER+R+  + +  E +R +Q  +  Q +R  R R+R          + D Q D  + R  
Sbjct: 5   RERKRETDRGKETERERDRQRERENQTERENRHRQRD------RHRERDRQTDREKERE- 57

Query: 140 GNLGKNPDVDTSFLPDRDREEEENRLREELRQ---EWEAQREKVKDEEME 186
               +  + D     +R+ E E  R RE  RQ   + +  RE+ KD + E
Sbjct: 58  ----RQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRE 103



 Score = 29.6 bits (65), Expect = 3.8
 Identities = 12/43 (27%), Positives = 27/43 (62%)

Query: 74  KARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRK 116
           + RQ    R+RE    +++  E +  ++ER++E+++ R+ K+K
Sbjct: 142 RERQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKK 184



 Score = 28.5 bits (62), Expect = 8.5
 Identities = 13/47 (27%), Positives = 31/47 (65%), Gaps = 4/47 (8%)

Query: 74  KARQEALVRER----ERQLAKRQHLEEQRLQQERQREQEQRRERKRK 116
           + R+    RER    ER+  K++  +E++ +++ ++++E+RRE K++
Sbjct: 148 RERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEKRREDKKR 194


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 37/181 (20%), Positives = 92/181 (50%), Gaps = 10/181 (5%)

Query: 8   MREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGL 67
           +RE  + +   KK   Q EQM+  ++++ E+     + +++     + +  + K      
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 351

Query: 68  VTLNDMKAR---QEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFAL 124
             + D + R   Q+  +RE+E ++ +++ + E   Q+E+ +E+E+ RER++K+      +
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQEKMWE---QEEKMQEEERIREREKKMREEEETM 408

Query: 125 DDLDDQADAAEARRAGNLGKNPDVDTSFLPD-RDREEEENRLREELRQEWEAQREKVKDE 183
            + +++    E        +  +     LP+ +++  E+ +++E+  + WE Q EK++D+
Sbjct: 409 REQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE-QEEKIRDQ 465

Query: 184 E 184
           E
Sbjct: 466 E 466



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 40/186 (21%), Positives = 86/186 (46%), Gaps = 8/186 (4%)

Query: 1   MAQYKGTMREAGRAMHLLKKRERQRE-QMEVLKQRIAEETILKSQVDKRFSAHYDAVEAE 59
           + + +G MRE    M   +KR R++E ++   ++ + E+  L+ Q ++         E E
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323

Query: 60  LKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISC 119
            K     +    +   RQE  + E+E+Q+  R+  ++ R Q+ER  EQ++R   K +   
Sbjct: 324 EK-----MREQEEKMWRQEERLWEQEKQM--REQEQKMRDQEERMWEQDERLREKEERMR 376

Query: 120 LSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREK 179
               + + +++    E  R        + +T    +   +++E  + E+  +EW+ QR  
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP 436

Query: 180 VKDEEM 185
            + E++
Sbjct: 437 EQKEKL 442



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 51/228 (22%), Positives = 105/228 (46%), Gaps = 30/228 (13%)

Query: 17  LLKKRERQREQMEVLKQ--RIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMK 74
           L +K ER REQ ++ +Q  ++ EE   + Q  K +                      + K
Sbjct: 516 LREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWD--------------------QEEK 555

Query: 75  ARQEALVRERERQLAKRQHLEEQRLQQERQREQEQR-RERKRKISCLSFALDDLDDQADA 133
            R+E  +RERE+++  R+  E  R Q+E+ +EQE++ RE++ K+      + + +++   
Sbjct: 556 MREEERMREREKKM--REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613

Query: 134 AEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEVTFSYWD 193
            E +    + +  + D     +    E+E +++E+  + WE Q EK++++E ++      
Sbjct: 614 QEEK----MWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWE-QEEKMREQEEKMREQEEK 668

Query: 194 GSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQLMFIKED 241
             G    +R ++     Q  K   Q  +    E +  G E+ M+ +E+
Sbjct: 669 MQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEE 716



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 43/188 (22%), Positives = 79/188 (42%), Gaps = 14/188 (7%)

Query: 18  LKKRERQREQMEV--LKQRIAEETILKSQVDKR-FSAHYDAVEAELKSSTVGLVTLNDMK 74
           L + E+   Q+ V  LK+++     L  QV            E EL+     +    +  
Sbjct: 198 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 257

Query: 75  ARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAA 134
            RQE  +RE+E ++  R+  E+ R Q++R REQE+    + K       L + ++Q    
Sbjct: 258 WRQEERLREQEGKM--REQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQ 315

Query: 135 EARRAGNLGKNPDVDTSFLPDRDR--------EEEENRLREELRQEWEA-QREKVKDEEM 185
           E +      K  + +       +R         E+E ++R++  + WE  +R + K+E M
Sbjct: 316 EEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 375

Query: 186 EVTFSYWD 193
                 W+
Sbjct: 376 REQEKMWE 383



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 41/181 (22%), Positives = 88/181 (48%), Gaps = 13/181 (7%)

Query: 19  KKRERQREQM-EVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQ 77
           +K  RQ E++ E  KQ   +E  ++ Q ++ +       E E +      +   + K ++
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390

Query: 78  EALVRERERQLAK-----RQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQAD 132
           E  +RERE+++ +     R+  E+ + Q+E   EQE++  +++++      L +  ++  
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE-QEKMQ 449

Query: 133 AAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEMEVTFSYW 192
             E +      K  D +  +  ++    +E ++RE+  Q WE Q EK++D+E ++    W
Sbjct: 450 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQE-KMREQEDQMWE-QEEKMRDQEQKM----W 503

Query: 193 D 193
           D
Sbjct: 504 D 504



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 44/209 (21%), Positives = 92/209 (44%), Gaps = 26/209 (12%)

Query: 1   MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL 60
           M + + TMRE    M   ++   ++E+ E  +QR+ E+     + +K         E E 
Sbjct: 401 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 460

Query: 61  KSSTVGLVTLNDMKARQEALVRERERQLAKRQHL---EEQRL---------QQERQREQE 108
           K      +   + K  ++  +RE+E Q+ +++     +EQ++         Q ER RE+E
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE 520

Query: 109 QRRERKRKISCLSFALDD-----------LDDQADAAEARRAGNLGKNPDVDTSFLPDRD 157
           +R   ++K+      + +            D +    E  R     K    +   + +++
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 580

Query: 158 R--EEEENRLREELRQEWEAQREKVKDEE 184
              +E+E ++RE+  + WE Q EK++++E
Sbjct: 581 EKMQEQEEKMREQEEKMWE-QEEKMQEQE 608



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 41/195 (21%), Positives = 83/195 (42%), Gaps = 22/195 (11%)

Query: 8   MREAGRAMHLLKKRERQREQMEVLKQRIAE-ETILKSQVDKRFSAHYDAVEAELK----S 62
           MRE  R     KK   + E M   ++++ E E  ++ Q +K +       E E K     
Sbjct: 556 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 615

Query: 63  STVGLVTLNDMKARQEALVRERERQLAKRQHL-----EEQRLQQERQREQEQR------- 110
             +      D    QE ++ E+E ++ +++       E+ R Q+E+ REQE++       
Sbjct: 616 EKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEK 675

Query: 111 -RERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREEL 169
            RE++ K+      + + +++    E +  G   K    +       +  E+E R+R++ 
Sbjct: 676 MREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQK 735

Query: 170 RQEWEAQREKVKDEE 184
               E  +E++ + E
Sbjct: 736 ----EKMQERLPEHE 746



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 41/180 (22%), Positives = 86/180 (47%), Gaps = 11/180 (6%)

Query: 17  LLKKRERQREQMEVLKQ--RIAEETILKSQVDKRFSAHYDAV---EAELKSSTVGLVTLN 71
           L +K ER REQ ++ +Q  ++ EE  ++ + +K+     + +   E +++     +    
Sbjct: 368 LREKEERMREQEKMWEQEEKMQEEERIRER-EKKMREEEETMREQEEKMQKQEENMWEQE 426

Query: 72  DMKARQEALVRERER--QLAKRQHLEEQRLQQERQ-REQEQRRERKRKISCLSFALDDLD 128
           + + +Q+ L  ++E+  +  K Q  EE+  +QE + R+QE+   +++K+       +  D
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486

Query: 129 DQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELR--QEWEAQREKVKDEEME 186
              +  E  R          +  +  D    E+E R+RE+ +  Q+ E  RE+ K +E E
Sbjct: 487 QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE 546


>gi|109150435 ankyrin repeat and zinc finger domain containing 1
           [Homo sapiens]
          Length = 726

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 37/85 (43%), Positives = 52/85 (61%), Gaps = 15/85 (17%)

Query: 72  DMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQR-RERKRKISCLSFALDDLDDQ 130
           +M+ARQ    R+RE++ A+RQ  E    QQ+RQ+EQE+R RE +R+ + LS    D + +
Sbjct: 609 EMEARQAT--RKREQKAARRQREE----QQQRQQEQEEREREEQRRFAALS----DREKR 658

Query: 131 ADAAEARRAGNLGKNPDVDTSFLPD 155
           A AAE R A  LG      TS +PD
Sbjct: 659 ALAAERRLAAQLG----APTSPIPD 679


>gi|109150425 ankyrin repeat and zinc finger domain containing 1
           [Homo sapiens]
          Length = 726

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 37/85 (43%), Positives = 52/85 (61%), Gaps = 15/85 (17%)

Query: 72  DMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQR-RERKRKISCLSFALDDLDDQ 130
           +M+ARQ    R+RE++ A+RQ  E    QQ+RQ+EQE+R RE +R+ + LS    D + +
Sbjct: 609 EMEARQAT--RKREQKAARRQREE----QQQRQQEQEEREREEQRRFAALS----DREKR 658

Query: 131 ADAAEARRAGNLGKNPDVDTSFLPD 155
           A AAE R A  LG      TS +PD
Sbjct: 659 ALAAERRLAAQLG----APTSPIPD 679


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 31/113 (27%), Positives = 56/113 (49%), Gaps = 18/113 (15%)

Query: 74  KARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADA 133
           K+R+    R R     KR+   E+  ++ER +E+++ +ER+R+                 
Sbjct: 360 KSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE----------------- 402

Query: 134 AEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
            E  +    GKN D D     DR++++E++R RE   +E E  R+K K++E +
Sbjct: 403 KEREKEKERGKNKDRDKEREKDREKDKEKDRERER-EKEHEKDRDKEKEKEQD 454



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 23/103 (22%), Positives = 53/103 (51%), Gaps = 8/103 (7%)

Query: 84  RERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLG 143
           R+++   R+ ++E+   +E+ RE+E+ RE++R+         D D + +  +  +     
Sbjct: 374 RDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREK-DREKDKEKD 432

Query: 144 KNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           +  + +     DRD+E+E+        Q+ E +REK + +E++
Sbjct: 433 REREREKEHEKDRDKEKEK-------EQDKEKEREKDRSKEID 468



 Score = 30.0 bits (66), Expect = 2.9
 Identities = 21/107 (19%), Positives = 52/107 (48%), Gaps = 1/107 (0%)

Query: 9   REAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLV 68
           R   R     + R   R++ +  +++I E+  +K +  ++        E E +       
Sbjct: 358 RSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDR 417

Query: 69  TLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKR 115
                K R++   ++RER+  K +H +++  ++E+++++E+ RE+ R
Sbjct: 418 DKEREKDREKDKEKDREREREK-EHEKDRDKEKEKEQDKEKEREKDR 463


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 31/113 (27%), Positives = 56/113 (49%), Gaps = 18/113 (15%)

Query: 74  KARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADA 133
           K+R+    R R     KR+   E+  ++ER +E+++ +ER+R+                 
Sbjct: 244 KSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE----------------- 286

Query: 134 AEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
            E  +    GKN D D     DR++++E++R RE   +E E  R+K K++E +
Sbjct: 287 KEREKEKERGKNKDRDKEREKDREKDKEKDRERER-EKEHEKDRDKEKEKEQD 338



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 23/103 (22%), Positives = 53/103 (51%), Gaps = 8/103 (7%)

Query: 84  RERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLG 143
           R+++   R+ ++E+   +E+ RE+E+ RE++R+         D D + +  +  +     
Sbjct: 258 RDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREK-DREKDKEKD 316

Query: 144 KNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           +  + +     DRD+E+E+        Q+ E +REK + +E++
Sbjct: 317 REREREKEHEKDRDKEKEK-------EQDKEKEREKDRSKEID 352



 Score = 30.0 bits (66), Expect = 2.9
 Identities = 21/107 (19%), Positives = 52/107 (48%), Gaps = 1/107 (0%)

Query: 9   REAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLV 68
           R   R     + R   R++ +  +++I E+  +K +  ++        E E +       
Sbjct: 242 RSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDR 301

Query: 69  TLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKR 115
                K R++   ++RER+  K +H +++  ++E+++++E+ RE+ R
Sbjct: 302 DKEREKDREKDKEKDREREREK-EHEKDRDKEKEKEQDKEKEREKDR 347


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 49/182 (26%), Positives = 86/182 (47%), Gaps = 21/182 (11%)

Query: 8   MREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGL 67
           +RE    MH   ++E+ REQ E   +R  EE I + +  +   A     E +++     +
Sbjct: 440 IRELEEKMH---EQEKIREQEE---KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 493

Query: 68  VTLNDMKARQEALVRERE--RQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALD 125
               +   RQE  + E+E  R+  KRQ  EE   Q+E+ REQE+   +K KI        
Sbjct: 494 REQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKI-------H 546

Query: 126 DLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWE---AQREKVKD 182
           + +++    E +      K  D +      R++EE+  R  E++R++ E    Q EK+++
Sbjct: 547 EQEEKIRKQEEKMWRQEEKMHDQEEKI---REQEEKVWRQEEKIREQEEKIREQEEKIRE 603

Query: 183 EE 184
           +E
Sbjct: 604 QE 605



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 41/179 (22%), Positives = 89/179 (49%), Gaps = 19/179 (10%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           ++ E+ REQ E +++   +E  ++ Q +  +       E +++     +    +   RQE
Sbjct: 379 EQEEKIREQEEKIRE---QEEKMRRQEEMMWEK-----EEKMRRQEEMMWEKEEKMRRQE 430

Query: 79  ALVRERE---RQLAKRQH-------LEEQRLQQERQREQEQRRERKRKISCLSFALDDLD 128
            ++ E+E   R+L ++ H        EE+R ++E+ REQE+R+E++ K+      + + +
Sbjct: 431 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 490

Query: 129 DQADAAEARRAGNLGKNPDVDTSFLPDRDREEEEN-RLREELRQEWEAQREKVKDEEME 186
           ++    E +      K  + +     ++ +E+EE  R  E++R++ E  R+K K  E E
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQE 549



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 43/184 (23%), Positives = 83/184 (45%), Gaps = 15/184 (8%)

Query: 5   KGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKR--FSAHYDAVEAELKS 62
           K   R+  RA  LL +++ Q E   + K+  +    L++QV++   ++      E ++  
Sbjct: 306 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWR 365

Query: 63  STVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSF 122
               +    +    QE  +RE+E ++  R+  E+ R Q+E   E+E++  R+ ++     
Sbjct: 366 QEEKIQEWEEKIQEQEEKIREQEEKI--REQEEKMRRQEEMMWEKEEKMRRQEEMMW--- 420

Query: 123 ALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKD 182
                       + RR   +    +     L ++  E+E+ R +EE RQE E  RE+ K 
Sbjct: 421 --------EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 472

Query: 183 EEME 186
           +E E
Sbjct: 473 QEQE 476



 Score = 34.3 bits (77), Expect = 0.16
 Identities = 34/175 (19%), Positives = 82/175 (46%), Gaps = 24/175 (13%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQE 78
           +K  RQ E+M   +++I E+     + +++        E +++     +    +M   QE
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ----EEKIREQEEKIREQEEMTQEQE 612

Query: 79  ALVRERERQLAKRQH-LEEQRLQQERQ----REQEQR-RERKRKISCLSFALDDLDDQAD 132
             + E+E ++ +++  ++EQ  +  RQ    REQE++ RE++ KI      + + +++  
Sbjct: 613 EKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 672

Query: 133 AAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQ-REKVKDEEME 186
             E +                 +   +E+E ++R +  + WE + R + ++E+M+
Sbjct: 673 EQEEKMCEQ-------------EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 40/181 (22%), Positives = 71/181 (39%), Gaps = 27/181 (14%)

Query: 12  GRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDK---RFSAHYDAVEAELKSSTVGLV 68
           G A  L+ +     +    L+Q ++     K + D+     +   DA+  EL  +T+   
Sbjct: 219 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 278

Query: 69  TLNDMKAR-QEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDL 127
            L +  A+ QE L                Q ++ E+   Q   +E KRK+      L   
Sbjct: 279 ELKEKNAKLQEKL----------------QLVESEKSEIQLNVKELKRKLERAKLLLPQQ 322

Query: 128 DDQADAAEARRAGNLGKN-PDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
             QA+A       +LGK    V        +  E  NRL ++  ++   Q EK+++ E +
Sbjct: 323 QLQAEA------DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK 376

Query: 187 V 187
           +
Sbjct: 377 I 377


>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 523

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 61/240 (25%), Positives = 111/240 (46%), Gaps = 36/240 (15%)

Query: 17  LLKKRERQREQMEVLKQ---RIAEETILKSQVDKRFSAHYDAV---EAELKSSTVGLVTL 70
           L ++ ER REQ E L++   R+ E+     + ++R     + +   E  L+     L   
Sbjct: 201 LREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQ 260

Query: 71  NDMKARQEALVRERERQLAKRQHLEEQRL--QQERQREQEQR--------RERKRKISCL 120
            +    QE  +RE+E +L    H +E+RL  Q+ER REQE+R        RE++ ++   
Sbjct: 261 EERLCEQEERLREQEERL----HEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQ 316

Query: 121 SFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEEN-----RLREELRQEWEA 175
              L + +++    E +  G      +V+     +R +EE+E      RL EE+ +  E 
Sbjct: 317 EERLREQEERLCEQE-KLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQ 375

Query: 176 QREKVKDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQL 235
           +R + +DE +      W     +   R+R+   +++ L+   + L +   E RS G E+L
Sbjct: 376 ERLRQQDERL------WQQETLQELERLRE---LERMLELGWEALYEQRAEPRS-GFEEL 425



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 37/138 (26%), Positives = 74/138 (53%), Gaps = 8/138 (5%)

Query: 54  DAVEAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHL---EEQRL--QQERQREQE 108
           ++V  +L++       L+ +  RQE  +RE+E +L +++     +E+RL  Q+ER REQE
Sbjct: 174 ESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQE 233

Query: 109 QR-RERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDRE-EEENRLR 166
           +R RE++ ++      L + +++    E R      +  + +       +R  E+E RLR
Sbjct: 234 ERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLR 293

Query: 167 EELRQEWEAQREKVKDEE 184
           E+  +  E Q E+++++E
Sbjct: 294 EQEERLCE-QEERLREQE 310



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 10/124 (8%)

Query: 71  NDMKARQEALVRERERQLAKRQHL------EEQRL--QQERQREQEQR-RERKRKISCLS 121
           N ++   E++ R+ + ++   Q L      +E+RL  Q+ER REQE+R RE++ ++    
Sbjct: 167 NHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQE 226

Query: 122 FALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDRE-EEENRLREELRQEWEAQREKV 180
             L + +++    E R      +  + +       +R  E+E RLRE+  +  E +    
Sbjct: 227 ERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLC 286

Query: 181 KDEE 184
           + EE
Sbjct: 287 EQEE 290



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 41/180 (22%), Positives = 72/180 (40%), Gaps = 17/180 (9%)

Query: 17  LLKKRERQREQMEVL---KQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDM 73
           L ++ ER REQ E L   ++R+ E+     + ++R     + +  + +        L + 
Sbjct: 264 LCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQ 323

Query: 74  KAR---------QEALVRERERQLAKRQHLEEQRLQQERQR-----EQEQRRERKRKISC 119
           + R         QE L+ E E+ L + +  EEQ    ER+R     E+   +ER R+   
Sbjct: 324 EERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERLRQQDE 383

Query: 120 LSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREK 179
             +  + L +     E  R   LG     +    P    EE  N  +  L+ E + +  K
Sbjct: 384 RLWQQETLQELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELK 443


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 39/170 (22%), Positives = 84/170 (49%), Gaps = 15/170 (8%)

Query: 18  LKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQ 77
           LK+ ER R+ ++  ++    +   K Q++++F+      + + K+       L + KA++
Sbjct: 572 LKREERLRKVLQARERVEQMKEEKKKQIEQKFA------QIDEKTEKAKEERLAEEKAKK 625

Query: 78  EALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEAR 137
           +A  ++ E   A+R+  EE R  +  Q+E+E+RR ++             ++Q    +A 
Sbjct: 626 KAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE------LLQKKKEEEQERLRKAA 679

Query: 138 RAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWE---AQREKVKDEE 184
            A  L +  + +      R++E  E   RE+ R+E E   A++E+ +++E
Sbjct: 680 EAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 729



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 43/178 (24%)

Query: 10  EAGRAMHLLKKRERQREQMEVLKQRIAEET--ILKSQVDKRFSAHYDAVEAELKSSTVGL 67
           E  R +  L++ E +R   E+L+++  EE   + K+   KR +   +    E        
Sbjct: 643 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE-------- 694

Query: 68  VTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQ---RRERKRKISCLSFAL 124
                 + R+E   RE+ER+  +R+  E Q  +QER+REQE+    RE + +   L    
Sbjct: 695 ------QERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK 748

Query: 125 DDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKD 182
           + L  +                      L ++ ++EE+ RL E  RQ  E Q +K K+
Sbjct: 749 EQLQRE----------------------LEEKKKKEEQQRLAE--RQLQEEQEKKAKE 782



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 47/187 (25%), Positives = 90/187 (48%), Gaps = 37/187 (19%)

Query: 24  QREQMEVLKQRIAEETILKSQVDKRFSAHYDA----VEAELKSSTVGLVTLNDMKARQEA 79
           QR QM ++    A  +++KS + +      D     VE E +        L +++ ++EA
Sbjct: 500 QRNQM-LMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQR-------LENLRRKEEA 551

Query: 80  -LVRERERQLAKRQHLEEQRLQQE---------RQREQEQRRERKRKISCLSFALDDLDD 129
             +R ++ +  KR+ LEE +L++E         R+R ++ + E+K++I      +D+  +
Sbjct: 552 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 611

Query: 130 QAD-----AAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQR-----EK 179
           +A        +A++     K  +V+      R ++EEE R    L+QE E +R     +K
Sbjct: 612 KAKEERLAEEKAKKKAAAKKMEEVEA-----RRKQEEEARRLRWLQQEEEERRHQELLQK 666

Query: 180 VKDEEME 186
            K+EE E
Sbjct: 667 KKEEEQE 673


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 39/170 (22%), Positives = 84/170 (49%), Gaps = 15/170 (8%)

Query: 18  LKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQ 77
           LK+ ER R+ ++  ++    +   K Q++++F+      + + K+       L + KA++
Sbjct: 568 LKREERLRKVLQARERVEQMKEEKKKQIEQKFA------QIDEKTEKAKEERLAEEKAKK 621

Query: 78  EALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEAR 137
           +A  ++ E   A+R+  EE R  +  Q+E+E+RR ++             ++Q    +A 
Sbjct: 622 KAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQE------LLQKKKEEEQERLRKAA 675

Query: 138 RAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWE---AQREKVKDEE 184
            A  L +  + +      R++E  E   RE+ R+E E   A++E+ +++E
Sbjct: 676 EAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 725



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 43/178 (24%)

Query: 10  EAGRAMHLLKKRERQREQMEVLKQRIAEET--ILKSQVDKRFSAHYDAVEAELKSSTVGL 67
           E  R +  L++ E +R   E+L+++  EE   + K+   KR +   +    E        
Sbjct: 639 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE-------- 690

Query: 68  VTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQ---RRERKRKISCLSFAL 124
                 + R+E   RE+ER+  +R+  E Q  +QER+REQE+    RE + +   L    
Sbjct: 691 ------QERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK 744

Query: 125 DDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKD 182
           + L  +                      L ++ ++EE+ RL E  RQ  E Q +K K+
Sbjct: 745 EQLQRE----------------------LEEKKKKEEQQRLAE--RQLQEEQEKKAKE 778



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/178 (25%), Positives = 83/178 (46%), Gaps = 23/178 (12%)

Query: 24  QREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVGLVTLNDMKARQEA-LVR 82
           QR QM ++    A  +++KS + +      D  E E +        L +++ ++EA  +R
Sbjct: 500 QRNQM-LMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQR-------LENLRRKEEAEQLR 551

Query: 83  ERERQLAKRQHLEEQRLQ-QERQREQEQRRER-----KRKISCLSFALDDLDDQADAAEA 136
            ++ +  KR+ LEE +L+ +ER R+  Q RER     + K   +      +D++ + A+ 
Sbjct: 552 RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611

Query: 137 RRAGNLGKNPDVDTSFLPD---RDREEEENRLREELRQEWEAQR-----EKVKDEEME 186
            R              + +   R ++EEE R    L+QE E +R     +K K+EE E
Sbjct: 612 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQE 669



 Score = 28.9 bits (63), Expect = 6.5
 Identities = 31/151 (20%), Positives = 62/151 (41%), Gaps = 13/151 (8%)

Query: 82  RERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGN 141
           +E+ERQ  +    +E+  Q  RQ+ +E +R R  ++       + L     A E      
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK--REERLRKVLQARERVEQMK 588

Query: 142 LGKNPDVDTSF--LPDRDREEEENRLREE---------LRQEWEAQREKVKDEEMEVTFS 190
             K   ++  F  + ++  + +E RL EE           +E EA+R++ ++        
Sbjct: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648

Query: 191 YWDGSGHRRTVRVRKGNTVQQFLKKALQGLR 221
             +     + +  +K    Q+ L+KA +  R
Sbjct: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKR 679


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 39/180 (21%), Positives = 82/180 (45%), Gaps = 11/180 (6%)

Query: 7   TMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSSTVG 66
           T RE+ R     ++RER++ + E  K+R  E    + +  K+     +      +     
Sbjct: 30  TQRESERKK---ERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR 86

Query: 67  LVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDD 126
                  + +++   ++RER+   R+  ++++ ++ER+RE +QRRERKRK         +
Sbjct: 87  KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146

Query: 127 LDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
              + +  +  R     K          +R+++ E NR   +  +E + +RE+ K+ + E
Sbjct: 147 RKREKERGKRERKRKKRKK--------EEREKKRERNRKERKKERERKERRERKKERKKE 198



 Score = 34.3 bits (77), Expect = 0.16
 Identities = 23/112 (20%), Positives = 52/112 (46%), Gaps = 8/112 (7%)

Query: 5   KGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAELKSST 64
           K   ++ GR     KK  ++RE+    ++    +   K +  K      +  + E K   
Sbjct: 103 KRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKK 162

Query: 65  VGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRK 116
                    K  +    RER R+  K++   ++R +++++R++E+R++++RK
Sbjct: 163 --------RKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERK 206



 Score = 32.0 bits (71), Expect = 0.77
 Identities = 22/102 (21%), Positives = 44/102 (43%), Gaps = 12/102 (11%)

Query: 85  ERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAAEARRAGNLGK 144
           E Q+    H+ +   Q+E +R++E+R   KRK             + +    R  G   K
Sbjct: 16  ELQMVSCSHISKPCTQRESERKKERREREKRK------------REREKERKRERGKKEK 63

Query: 145 NPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
                     +R+R+ +E   + + R+E E ++ K + ++ E
Sbjct: 64  KKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRE 105



 Score = 29.3 bits (64), Expect = 5.0
 Identities = 25/138 (18%), Positives = 60/138 (43%), Gaps = 7/138 (5%)

Query: 56  VEAELKSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQ-------QERQREQE 108
           +  EL+  +   ++    +   E     RER+  KR+  +E++ +       + ++RE+ 
Sbjct: 13  LNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERG 72

Query: 109 QRRERKRKISCLSFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREE 168
           + RERKRK            ++    + ++     +    +     +R   E EN+ R E
Sbjct: 73  KERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE 132

Query: 169 LRQEWEAQREKVKDEEME 186
            +++   ++++ K+ + E
Sbjct: 133 RKRKKRRKKKRRKERKRE 150


>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
           [Homo sapiens]
          Length = 213

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 33/118 (27%), Positives = 56/118 (47%), Gaps = 24/118 (20%)

Query: 74  KARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADA 133
           + R+     +RER  AK    E++  +++RQR++E+ RER R             D+   
Sbjct: 19  RQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDR-------------DRERE 65

Query: 134 AEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQ-----EWEAQREKVKDEEME 186
            +  R G   +  +       DRDR+ E  R R++ R+     E + +R+K K+ EME
Sbjct: 66  KQTDREGERQRERE------RDRDRQRETERERDKERETDRHTETDRERQKQKEREME 117



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 43/164 (26%), Positives = 67/164 (40%), Gaps = 21/164 (12%)

Query: 5   KGTMREAGRAMHLLKKRERQRE-QMEVLKQRIAE---ETILKSQVDKRFSAHYDAVEAEL 60
           K T RE  R     + R+RQRE + E  K+R  +   ET  + Q  K             
Sbjct: 66  KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRERE 125

Query: 61  KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL 120
           K   +G     D +       RERERQ  + +    +R  ++R RE+E+ R+R+R     
Sbjct: 126 KQKEMGRERQTDRETD-----RERERQAERERETGRERKTEDRHRERERERKRER----- 175

Query: 121 SFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENR 164
                  + + +  E  R  ++ +    +T    DR RE E  R
Sbjct: 176 -------ERKRETKERERHTDMERERQRETDRKRDRQRESERER 212



 Score = 37.7 bits (86), Expect = 0.014
 Identities = 29/98 (29%), Positives = 47/98 (47%), Gaps = 7/98 (7%)

Query: 90  KRQHLEEQRLQQERQREQEQRRERKR-KISCLSFALDDLDDQADAAEARRAGNLGKNPDV 148
           +  H E + + ++R+R +E  RER R K S       + D Q D     R  N  ++ D 
Sbjct: 8   RHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRD-----RERNRERDRDR 62

Query: 149 DTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
           +     DR+ E +  R R+  RQ  E +RE+ K+ E +
Sbjct: 63  EREKQTDREGERQRERERDRDRQR-ETERERDKERETD 99



 Score = 37.4 bits (85), Expect = 0.018
 Identities = 31/115 (26%), Positives = 52/115 (45%), Gaps = 11/115 (9%)

Query: 76  RQEALVRERERQLAKRQHLE---EQRLQQERQREQEQRRER-KRKISCLSFALDDLDDQA 131
           RQ    RER+++    +H E   E++ Q+ER+ E+ + RER K+K        D   D+ 
Sbjct: 84  RQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRE 143

Query: 132 DAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKVKDEEME 186
              +A R    G+    +       DR  E  R R+  R+     +E+ +  +ME
Sbjct: 144 RERQAERERETGRERKTE-------DRHRERERERKRERERKRETKERERHTDME 191


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 37/170 (21%), Positives = 87/170 (51%), Gaps = 21/170 (12%)

Query: 19  KKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAE-LKSSTVGLVTLNDMKARQ 77
           K+R RQ+ ++    +R  +    + + ++R      A  AE LK     L  L    + +
Sbjct: 446 KQRRRQQSEISAAVERARKR---REEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPE 502

Query: 78  EALVRERERQLAKRQHLE---EQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAA 134
           E   RERE++  + + LE   EQ  ++ER++++E+++E+++++           +Q    
Sbjct: 503 EIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELE---------KEQEKQR 553

Query: 135 EARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQ-EWEAQREKVKDE 183
           E  +     K  +++      +++E+E  +++E+ ++ E E +REK++++
Sbjct: 554 EMEKERKQEKEKELER----QKEKEKELQKMKEQEKECELEKEREKLEEK 599



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 35/113 (30%), Positives = 61/113 (53%), Gaps = 16/113 (14%)

Query: 75  ARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCLSFALDDLDDQADAA 134
           A ++ + ++R RQ ++     E+   ++R+ E+E+R E +RK +C    L  LD+     
Sbjct: 439 ADEDEIWKQRRRQQSEISAAVERA--RKRREEEERRMEEQRKAACAE-KLKRLDE----- 490

Query: 135 EARRAGNLGKNPDVDTSFLPDRDREEEENRLRE-ELRQEWEAQREKVKDEEME 186
              + G L K P  +      R+RE E+ R RE EL +E E +REK ++++ E
Sbjct: 491 ---KLGILEKQPSPEEI----REREREKEREREKELEKEQEQEREKEREKDRE 536



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 24/115 (20%)

Query: 85  ERQLAKRQHLEEQRLQQE------------RQREQEQRRERKRKISCLSFALDDLDDQAD 132
           ++Q+A    + +QR +Q+            R+ E+E+R E +RK +C    L  LD+   
Sbjct: 435 KQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAE-KLKRLDE--- 490

Query: 133 AAEARRAGNLGKNPDVDTSFLPDRDREEEENRLRE-ELRQEWEAQREKVKDEEME 186
                + G L K P  +   + +R+RE+E  R +E E  QE E ++E+ KD E +
Sbjct: 491 -----KLGILEKQPSPEE--IREREREKEREREKELEKEQEQEREKEREKDRERQ 538



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 27/121 (22%), Positives = 64/121 (52%), Gaps = 8/121 (6%)

Query: 74  KARQEALVRERERQLAKRQHLEEQRLQQERQR---EQEQRRERKRKISCLSFALDDLDDQ 130
           + RQ++ +     +  KR+  EE+R++++R+    E+ +R + K  I     + +++ ++
Sbjct: 448 RRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIRER 507

Query: 131 ADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLRE-----ELRQEWEAQREKVKDEEM 185
               E  R   L K  + +     ++DRE ++ + +E     E ++E E +R++ K++E+
Sbjct: 508 EREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKEL 567

Query: 186 E 186
           E
Sbjct: 568 E 568


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,656,877
Number of Sequences: 37866
Number of extensions: 524855
Number of successful extensions: 14293
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 297
Number of HSP's successfully gapped in prelim test: 694
Number of HSP's that attempted gapping in prelim test: 5441
Number of HSP's gapped (non-prelim): 4084
length of query: 325
length of database: 18,247,518
effective HSP length: 102
effective length of query: 223
effective length of database: 14,385,186
effective search space: 3207896478
effective search space used: 3207896478
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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