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Search of human proteins with 66912178
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66912178 neuropilin 1 isoform b [Homo sapiens]
(644 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66912178 neuropilin 1 isoform b [Homo sapiens] 1344 0.0
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 1338 0.0
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 1250 0.0
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 644 0.0
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 644 0.0
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 644 0.0
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 644 0.0
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 644 0.0
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 585 e-167
gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Ho... 169 6e-42
gi|31317224 EGF-like repeats and discoidin I-like domains-contai... 169 7e-42
gi|4503647 coagulation factor VIII isoform a precursor [Homo sap... 160 3e-39
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 151 2e-36
gi|22547221 tolloid-like 1 [Homo sapiens] 142 1e-33
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 141 2e-33
gi|6912724 tolloid-like 2 [Homo sapiens] 139 6e-33
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 139 8e-33
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 139 8e-33
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 139 8e-33
gi|105990535 coagulation factor V precursor [Homo sapiens] 138 2e-32
gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo sa... 138 2e-32
gi|126091152 cubilin [Homo sapiens] 132 1e-30
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 130 3e-30
gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Ho... 115 2e-25
gi|10518506 coagulation factor VIII isoform b precursor [Homo sa... 113 5e-25
gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo sa... 110 4e-24
gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3 pre... 102 8e-22
gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2 pre... 102 8e-22
gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Ho... 101 2e-21
gi|62420886 discoidin domain receptor family, member 2 precursor... 96 8e-20
>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
Length = 644
Score = 1344 bits (3479), Expect = 0.0
Identities = 644/644 (100%), Positives = 644/644 (100%)
Query: 1 MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
Sbjct: 1 MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
Query: 61 PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
Sbjct: 61 PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
Query: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP
Sbjct: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
Query: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
Sbjct: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
Query: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
Sbjct: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
Query: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
Sbjct: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
Query: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
Sbjct: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
Query: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
Sbjct: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
Query: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
Sbjct: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
Query: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV
Sbjct: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600
Query: 601 DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSGIK 644
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSGIK
Sbjct: 601 DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSGIK 644
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 1338 bits (3464), Expect = 0.0
Identities = 641/641 (100%), Positives = 641/641 (100%)
Query: 1 MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
Sbjct: 1 MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
Query: 61 PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
Sbjct: 61 PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
Query: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP
Sbjct: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
Query: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
Sbjct: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
Query: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
Sbjct: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
Query: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
Sbjct: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
Query: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
Sbjct: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
Query: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
Sbjct: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
Query: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
Sbjct: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
Query: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV
Sbjct: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600
Query: 601 DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQS 641
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQS
Sbjct: 601 DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQS 641
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 1250 bits (3234), Expect = 0.0
Identities = 609/644 (94%), Positives = 609/644 (94%), Gaps = 35/644 (5%)
Query: 1 MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
Sbjct: 1 MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
Query: 61 PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
Sbjct: 61 PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
Query: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP
Sbjct: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
Query: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
Sbjct: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
Query: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
Sbjct: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
Query: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
Sbjct: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
Query: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
Sbjct: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
Query: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
Sbjct: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
Query: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
Sbjct: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
Query: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVE
Sbjct: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVE-------------- 586
Query: 601 DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSGIK 644
GGTTVLATEKPTVIDSTIQSGIK
Sbjct: 587 ---------------------GGTTVLATEKPTVIDSTIQSGIK 609
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 644 bits (1662), Expect = 0.0
Identities = 308/617 (49%), Positives = 423/617 (68%), Gaps = 21/617 (3%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG + + GY+TSPGYP Y + CEW++ AP+P Q+I++NFNPHF++E DCKYD+
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
+E+ DG++E+ GK CG IAPP ++SSG L+IKF SDY GAGFS+RYEIFK G E
Sbjct: 88 IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A EIIL+F FDLE D G
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
C+YD L+IWDG P VGP IG+YCG KTP +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
E+F+C LGMESG I ++QI+ASS YS W+ ++SRL+ +NGWTP DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
++QVDL L +TA+ TQGAIS+ET+ YYVK+YK++VS+NGEDW+ + G +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
+ T+VV+ PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
SQI++S+ + W P RLV+SRSGW P P + EWLQ+DLG K V+G+IIQG
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
+ E + F+RKFK+ YS NG DW+ I D ++ K FEGN +YDTP++R F +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566
Query: 558 STRFIRIYPERATHGGLGLRMELLGCE-----VEAPTAGPTTPNGNLV------DECDDD 606
+++R+YPER + G+G+R+E+LGC+ T GPT + +E +
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATEC 626
Query: 607 QANCHSGTGDDFQLTGG 623
NC D QL G
Sbjct: 627 GENCSFEDDKDLQLPSG 643
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 644 bits (1662), Expect = 0.0
Identities = 308/617 (49%), Positives = 423/617 (68%), Gaps = 21/617 (3%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG + + GY+TSPGYP Y + CEW++ AP+P Q+I++NFNPHF++E DCKYD+
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
+E+ DG++E+ GK CG IAPP ++SSG L+IKF SDY GAGFS+RYEIFK G E
Sbjct: 88 IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A EIIL+F FDLE D G
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
C+YD L+IWDG P VGP IG+YCG KTP +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
E+F+C LGMESG I ++QI+ASS YS W+ ++SRL+ +NGWTP DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
++QVDL L +TA+ TQGAIS+ET+ YYVK+YK++VS+NGEDW+ + G +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
+ T+VV+ PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
SQI++S+ + W P RLV+SRSGW P P + EWLQ+DLG K V+G+IIQG
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
+ E + F+RKFK+ YS NG DW+ I D ++ K FEGN +YDTP++R F +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566
Query: 558 STRFIRIYPERATHGGLGLRMELLGCE-----VEAPTAGPTTPNGNLV------DECDDD 606
+++R+YPER + G+G+R+E+LGC+ T GPT + +E +
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATEC 626
Query: 607 QANCHSGTGDDFQLTGG 623
NC D QL G
Sbjct: 627 GENCSFEDDKDLQLPSG 643
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 644 bits (1662), Expect = 0.0
Identities = 308/617 (49%), Positives = 423/617 (68%), Gaps = 21/617 (3%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG + + GY+TSPGYP Y + CEW++ AP+P Q+I++NFNPHF++E DCKYD+
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
+E+ DG++E+ GK CG IAPP ++SSG L+IKF SDY GAGFS+RYEIFK G E
Sbjct: 88 IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A EIIL+F FDLE D G
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
C+YD L+IWDG P VGP IG+YCG KTP +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
E+F+C LGMESG I ++QI+ASS YS W+ ++SRL+ +NGWTP DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
++QVDL L +TA+ TQGAIS+ET+ YYVK+YK++VS+NGEDW+ + G +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
+ T+VV+ PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
SQI++S+ + W P RLV+SRSGW P P + EWLQ+DLG K V+G+IIQG
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
+ E + F+RKFK+ YS NG DW+ I D ++ K FEGN +YDTP++R F +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566
Query: 558 STRFIRIYPERATHGGLGLRMELLGCE-----VEAPTAGPTTPNGNLV------DECDDD 606
+++R+YPER + G+G+R+E+LGC+ T GPT + +E +
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATEC 626
Query: 607 QANCHSGTGDDFQLTGG 623
NC D QL G
Sbjct: 627 GENCSFEDDKDLQLPSG 643
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 644 bits (1662), Expect = 0.0
Identities = 308/617 (49%), Positives = 423/617 (68%), Gaps = 21/617 (3%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG + + GY+TSPGYP Y + CEW++ AP+P Q+I++NFNPHF++E DCKYD+
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
+E+ DG++E+ GK CG IAPP ++SSG L+IKF SDY GAGFS+RYEIFK G E
Sbjct: 88 IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A EIIL+F FDLE D G
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
C+YD L+IWDG P VGP IG+YCG KTP +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
E+F+C LGMESG I ++QI+ASS YS W+ ++SRL+ +NGWTP DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
++QVDL L +TA+ TQGAIS+ET+ YYVK+YK++VS+NGEDW+ + G +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
+ T+VV+ PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
SQI++S+ + W P RLV+SRSGW P P + EWLQ+DLG K V+G+IIQG
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
+ E + F+RKFK+ YS NG DW+ I D ++ K FEGN +YDTP++R F +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566
Query: 558 STRFIRIYPERATHGGLGLRMELLGCE-----VEAPTAGPTTPNGNLV------DECDDD 606
+++R+YPER + G+G+R+E+LGC+ T GPT + +E +
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATEC 626
Query: 607 QANCHSGTGDDFQLTGG 623
NC D QL G
Sbjct: 627 GENCSFEDDKDLQLPSG 643
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 644 bits (1662), Expect = 0.0
Identities = 308/617 (49%), Positives = 423/617 (68%), Gaps = 21/617 (3%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG + + GY+TSPGYP Y + CEW++ AP+P Q+I++NFNPHF++E DCKYD+
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
+E+ DG++E+ GK CG IAPP ++SSG L+IKF SDY GAGFS+RYEIFK G E
Sbjct: 88 IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A EIIL+F FDLE D G
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
C+YD L+IWDG P VGP IG+YCG KTP +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
E+F+C LGMESG I ++QI+ASS YS W+ ++SRL+ +NGWTP DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
++QVDL L +TA+ TQGAIS+ET+ YYVK+YK++VS+NGEDW+ + G +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
+ T+VV+ PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
SQI++S+ + W P RLV+SRSGW P P + EWLQ+DLG K V+G+IIQG
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
+ E + F+RKFK+ YS NG DW+ I D ++ K FEGN +YDTP++R F +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566
Query: 558 STRFIRIYPERATHGGLGLRMELLGCE-----VEAPTAGPTTPNGNLV------DECDDD 606
+++R+YPER + G+G+R+E+LGC+ T GPT + +E +
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATEC 626
Query: 607 QANCHSGTGDDFQLTGG 623
NC D QL G
Sbjct: 627 GENCSFEDDKDLQLPSG 643
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 585 bits (1508), Expect = e-167
Identities = 275/521 (52%), Positives = 373/521 (71%), Gaps = 10/521 (1%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG + + GY+TSPGYP Y + CEW++ AP+P Q+I++NFNPHF++E DCKYD+
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
+E+ DG++E+ GK CG IAPP ++SSG L+IKF SDY GAGFS+RYEIFK G E
Sbjct: 88 IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A EIIL+F FDLE D G
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
C+YD L+IWDG P VGP IG+YCG KTP +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
E+F+C LGMESG I ++QI+ASS YS W+ ++SRL+ +NGWTP DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
++QVDL L +TA+ TQGAIS+ET+ YYVK+YK++VS+NGEDW+ + G +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
+ T+VV+ PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
SQI++S+ + W P RLV+SRSGW P P + EWLQ+DLG K V+G+IIQG
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAK 538
+ E + F+RKFK+ YS NG DW+ I D ++ K
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPK 547
Score = 133 bits (335), Expect = 4e-31
Identities = 128/453 (28%), Positives = 201/453 (44%), Gaps = 75/453 (16%)
Query: 155 SGVIKSPGFPEKYPNSLECTYIVFAPKMSE-IILEFES-FDLEPDSNPPGGMFCRYDRLE 212
+G I SPG+P+ YP+ C +IV+AP+ ++ I+L F F++E C+YD +E
Sbjct: 37 AGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-------CKYDFIE 89
Query: 213 IWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSED 272
I DG + +G++CG P I SS +L + F +D A GFS Y + ++ SED
Sbjct: 90 IRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG-SED 148
Query: 273 FKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGL 332
C + +G I S +Y N + L P+
Sbjct: 149 --CSKNFTSPNGTIESPGFP--EKYPHNLDCTFTILAKPK-------------------- 184
Query: 333 LRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGE-----DWITIKEGNKPV-----LFQ 382
E ++ + + D GE DW+ I +G V +
Sbjct: 185 --------------MEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYC 230
Query: 383 GNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE-VYGCKITDYPCSGMLGMVSGL 441
G P+++ + +++ A + G S R+ V+ + ++ C+ LGM SG
Sbjct: 231 GTKTPSELRSST---GILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGR 287
Query: 442 ISDSQIT-SSNQGDRNWMPENIRLVTSRSGWALPPAPHSYIN-EWLQIDLGEEKIVRGII 499
I++ QI+ SS D W P+ RL +GW P+ N E+LQ+DL ++ I
Sbjct: 288 IANEQISASSTYSDGRWTPQQSRLHGDDNGWT----PNLDSNKEYLQVDLRFLTMLTAIA 343
Query: 500 IQGGKHRE--NKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPA- 556
QG RE N +++ +K+ S NG DW + K F+ NN+ L A
Sbjct: 344 TQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANNDATEVVLNKLHAP 401
Query: 557 LSTRFIRIYPERATHGGLGLRMELLGCEV-EAP 588
L TRF+RI P+ H G+ LR+EL GC V +AP
Sbjct: 402 LLTRFVRIRPQ-TWHSGIALRLELFGCRVTDAP 433
>gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Homo
sapiens]
Length = 387
Score = 169 bits (429), Expect = 6e-42
Identities = 123/355 (34%), Positives = 183/355 (51%), Gaps = 33/355 (9%)
Query: 246 VFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYST-----N 300
VF + + +G++ N+ + KC+E LG+E+G I + QI ASS T +
Sbjct: 49 VFPSYTCTCLKGYAGNHC--------ETKCVEPLGLENGNIANSQIAASSVRVTFLGLQH 100
Query: 301 WSAERSRLNYPE--NGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTY 358
W E +RLN N WTP + WIQV+L +VT V TQGA + + Y+K +
Sbjct: 101 WVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHE--YLKAF 158
Query: 359 KIDVSSNGEDWITIKEGNKPVL-FQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISM 417
K+ S NG ++ I + NK F GN N V V +F P+ ++VR+ P + T ++
Sbjct: 159 KVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTL 218
Query: 418 RFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDR------NWMPENIRLVTSRSGW 471
RFE+ GC++ C+ LG+ + I D QIT+S+ +W P RL + G
Sbjct: 219 RFELLGCELNG--CANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARL--DKQGN 274
Query: 472 ALPPAPHSYINE-WLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIM 530
SY N+ WLQ+DLG K V GII QG ++ + F+ +K+ YSN+ ++W
Sbjct: 275 FNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQ 334
Query: 531 DDSKRKAKSFEGN--NNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGC 583
D +K F GN N+ L P L+ R++RI P A H + LR+ELLGC
Sbjct: 335 DPRTGSSKIFPGNWDNHSHKKNLFETPILA-RYVRILPV-AWHNRIALRLELLGC 387
Score = 82.8 bits (203), Expect = 9e-16
Identities = 61/189 (32%), Positives = 95/189 (50%), Gaps = 15/189 (7%)
Query: 431 CSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSRSGWALPPAPHSYI-NEW 484
C LG+ +G I++SQI +S+ G ++W+PE RL +R+G P S N W
Sbjct: 70 CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARL--NRAGMVNAWTPSSNDDNPW 127
Query: 485 LQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNN 544
+Q++L V G++ QG + +++ FK+ YS NG ++ I D +K K K F GN
Sbjct: 128 IQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNK-KHKEFVGNW 186
Query: 545 NYDTPELRTFPA-LSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDEC 603
N + + F + +++R+YP + H LR ELLGCE+ G P G +
Sbjct: 187 NKNAVHVNLFETPVEAQYVRLYPT-SCHTACTLRFELLGCELN----GCANPLGLKNNSI 241
Query: 604 DDDQANCHS 612
D Q S
Sbjct: 242 PDKQITASS 250
>gi|31317224 EGF-like repeats and discoidin I-like
domains-containing protein 3 [Homo sapiens]
Length = 480
Score = 169 bits (428), Expect = 7e-42
Identities = 118/332 (35%), Positives = 168/332 (50%), Gaps = 26/332 (7%)
Query: 273 FKCMEALGMESGEIHSDQITASSQYST-----NWSAERSRLNYPE--NGWTPGEDSYREW 325
+KC LG+E G I + QITASS + W +RLN N WT E+ W
Sbjct: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
Query: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWIT--IKEGNKPVLFQG 383
IQ++L VT V TQGA K Y+K+YKI S++G+ W +K N+ ++F+G
Sbjct: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
Query: 384 NTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLIS 443
N + F P+ ++VR+ P ++R E+ GC+++ CS LGM SG I
Sbjct: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
Query: 444 DSQITSS------NQGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
D QIT+S N W P RL + W + H+ ++WLQ+DL V
Sbjct: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWT---SGHNDQSQWLQVDLLVPTKV 388
Query: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
GII QG K + F+ +K+ YSN+G W + D+ +RK K F+GN + DT
Sbjct: 389 TGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVID 448
Query: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEVE 586
P + R IRI P + +G + LR ELLGC E
Sbjct: 449 PPIYARHIRILP-WSWYGRITLRSELLGCTEE 479
Score = 91.7 bits (226), Expect = 2e-18
Identities = 59/181 (32%), Positives = 92/181 (50%), Gaps = 12/181 (6%)
Query: 429 YPCSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSR--SGWALPPAPHSYI 481
Y CSG LG+ G+IS+ QIT+S+ G + W P RL + W A +
Sbjct: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWT---AAENDR 212
Query: 482 NEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFE 541
W+QI+L + V G+I QG K + +++ +KI YSN+G W M + F
Sbjct: 213 WPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFR 272
Query: 542 GNNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600
GN + +TP +F P + +++R+YP+ LRMELLGCE+ + +G++
Sbjct: 273 GNIDNNTPYANSFTPPIKAQYVRLYPQ-VCRRHCTLRMELLGCELSGCSEPLGMKSGHIQ 331
Query: 601 D 601
D
Sbjct: 332 D 332
>gi|4503647 coagulation factor VIII isoform a precursor [Homo sapiens]
Length = 2351
Score = 160 bits (405), Expect = 3e-39
Identities = 109/321 (33%), Positives = 164/321 (51%), Gaps = 19/321 (5%)
Query: 274 KCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPE--NGWTPGEDSYREWIQVDLG 331
KC LGM SG I QITAS QY W+ + +RL+Y N W+ E WI+VDL
Sbjct: 2039 KCQTPLGMASGHIRDFQITASGQYG-QWAPKLARLHYSGSINAWSTKEPF--SWIKVDLL 2095
Query: 332 LLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVL--FQGNTNPTD 389
+ + TQGA K + Y+ + I S +G+ W T + + L F GN + +
Sbjct: 2096 APMIIHGIKTQGARQKFSS--LYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSG 2153
Query: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITS 449
+ +F P+I R++R+ P + ++R E+ GC + CS LGM S ISD+QIT+
Sbjct: 2154 IKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDAQITA 2211
Query: 450 SNQGDR---NWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHR 506
S+ W P RL A P ++ EWLQ+D + V G+ QG K
Sbjct: 2212 SSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNP-KEWLQVDFQKTMKVTGVTTQGVKSL 2270
Query: 507 ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIY 565
+++++F I S +G W + + K K F+GN + TP + + P L TR++RI+
Sbjct: 2271 LTSMYVKEFLISSSQDGHQWTLFFQNG--KVKVFQGNQDSFTPVVNSLDPPLLTRYLRIH 2328
Query: 566 PERATHGGLGLRMELLGCEVE 586
P+ H + LRME+LGCE +
Sbjct: 2329 PQSWVH-QIALRMEVLGCEAQ 2348
Score = 103 bits (257), Expect = 5e-22
Identities = 62/159 (38%), Positives = 83/159 (52%), Gaps = 7/159 (4%)
Query: 275 CMEALGMESGEIHSDQITASSQYST---NWSAERSRLNYP--ENGWTPGEDSYREWIQVD 329
C LGMES I QITASS ++ WS ++RL+ N W P ++ +EW+QVD
Sbjct: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252
Query: 330 LGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTD 389
VT V TQG S T YVK + I S +G W + K +FQGN +
Sbjct: 2253 FQKTMKVTGVTTQGVKSLLTSM--YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 2310
Query: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITD 428
VV PL+TR++RI P +W I++R EV GC+ D
Sbjct: 2311 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 2349
Score = 76.3 bits (186), Expect = 8e-14
Identities = 61/179 (34%), Positives = 91/179 (50%), Gaps = 19/179 (10%)
Query: 414 GISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRS--GW 471
G+S F VY K C LGM SG I D QIT+S Q + W P+ RL S S W
Sbjct: 2028 GMSTLFLVYSNK-----CQTPLGMASGHIRDFQITASGQYGQ-WAPKLARLHYSGSINAW 2081
Query: 472 ALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMD 531
+ P S W+++DL I+ GI QG + + + +++ +F I YS +G W+
Sbjct: 2082 STKE-PFS----WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRG 2136
Query: 532 DSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIYPERATHGGL--GLRMELLGCEVEA 587
+S F GN + + F P + R+IR++P TH + LRMEL+GC++ +
Sbjct: 2137 NSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHP---THYSIRSTLRMELMGCDLNS 2192
>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
Length = 449
Score = 151 bits (382), Expect = 2e-36
Identities = 88/253 (34%), Positives = 135/253 (53%), Gaps = 16/253 (6%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
CG +K ES GY+ S G+P+ Y P+++C W I P+ Q + ++F FDLE C+YD
Sbjct: 37 CGGDVKGES-GYVASEGFPNLYPPNKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYD 93
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE-IFKRG 144
+EVF G +G G+FCG P P+V+ G + ++ +D T G GF + Y G
Sbjct: 94 ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSG 153
Query: 145 PE---CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
E C G + +P +PE YP + C++ + AP I L FE FDLEPD+
Sbjct: 154 TEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT-- 211
Query: 201 PGGMFCRYDRLEIWDG-FPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
+CRYD + +++G D +G++CG PG I S L + F +D ++ +GFS
Sbjct: 212 ----YCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFS 267
Query: 260 ANYSVLQSSVSED 272
A+Y L +++
Sbjct: 268 ASYKTLPRGTAKE 280
Score = 70.5 bits (171), Expect = 5e-12
Identities = 49/172 (28%), Positives = 74/172 (43%), Gaps = 25/172 (14%)
Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
C + SG + S GFP YP + EC + + P+ + L F FDLE +P C
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLE--LHPA----C 90
Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
RYD LE++ G G +GR+CG P + + +++ TD GF YS
Sbjct: 91 RYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150
Query: 267 SSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPG 318
+S +E C G + Q T ++ N+PE+ + PG
Sbjct: 151 TSGTEHQFC-------GGRLEKAQGTLTTP------------NWPESDYPPG 183
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 142 bits (357), Expect = 1e-33
Identities = 86/265 (32%), Positives = 131/265 (49%), Gaps = 19/265 (7%)
Query: 22 FRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD 81
+R CG+T++ ES G L+SPG+P+ Y C W + P ++I++NF +
Sbjct: 344 YRCPACGETLQ-ESNGNLSSPGFPNGYPSYTHCIWRVSVT-PGEKIVLNFTTMDLYKSSL 401
Query: 82 CKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIF 141
C YDY+EV DG G+FCG P + S+ ++I+F S G GF+ YE
Sbjct: 402 CWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
Query: 142 KRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPP 201
C G I+SP +P+ Y EC + + + + L F+SF++E N
Sbjct: 462 -----CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDN-- 514
Query: 202 GGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN 261
C YD LE+ DG + P IGR+CG P IRS+S L M F +D + K GF+AN
Sbjct: 515 ----CAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAAN 570
Query: 262 YSVLQSSVSE------DFKCMEALG 280
+ + ++ + +C+ LG
Sbjct: 571 FFKEEDECAKPDRGGCEQRCLNTLG 595
Score = 139 bits (350), Expect = 8e-33
Identities = 89/300 (29%), Positives = 141/300 (47%), Gaps = 57/300 (19%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
CG I+ ++ G + SP YP Y P ++C W I + Y + + F F++E D C YD
Sbjct: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSESYH-VGLTFQS-FEIERHDNCAYD 518
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Y+EV DG +EN G+FCG P + S+ L++KFVSD + AGF+ + FK
Sbjct: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF--FKEED 576
Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
EC++ T +G I +PG+P+
Sbjct: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK 636
Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
+YP + C + V AP I ++FE F+LE G C+YD +EIW G G
Sbjct: 637 EYPPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHG 690
Query: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSED-----FKCMEALG 280
++CG + P I S + + F +D+ ++K+GF A++ + S+D +C+ +G
Sbjct: 691 KFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMG 750
Score = 138 bits (348), Expect = 1e-32
Identities = 82/266 (30%), Positives = 124/266 (46%), Gaps = 47/266 (17%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
G +T+PG+P Y P++ C W + AP Y RI + F F+LE + CKYDYVE++ G +
Sbjct: 627 GTITTPGWPKEYPPNKNCVWQVVAPTQY-RISVKFE-FFELEGNEVCKYDYVEIWSGLSS 684
Query: 96 NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK------------- 142
GKFCG P + S + I+F SD GF + K
Sbjct: 685 ESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHE 744
Query: 143 -------------------------RGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIV 177
+ EC Q +PSG+I SP +P+KYP+ ECT+ +
Sbjct: 745 CVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEI 804
Query: 178 FAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIR 237
A I L F F++E C YD LE++DG + P +GR CG K P +
Sbjct: 805 SATPGHRIKLAFSEFEIEQHQE------CAYDHLEVFDGETEKSPILGRLCGNKIPDPLV 858
Query: 238 SSSGILSMVFYTDSAIAKEGFSANYS 263
++ + + F +D+++ ++GF A +S
Sbjct: 859 ATGNKMFVRFVSDASVQRKGFQATHS 884
Score = 133 bits (334), Expect = 6e-31
Identities = 77/241 (31%), Positives = 127/241 (52%), Gaps = 19/241 (7%)
Query: 32 KIESP-GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLED-RDCKYDYVEV 89
KI SP G +TSP +P Y ++C W I A P RI + F+ F++E ++C YD++EV
Sbjct: 777 KIHSPSGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAFS-EFEIEQHQECAYDHLEV 834
Query: 90 FDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECS- 148
FDGE E G+ CG P P+V++G +F++FVSD GF + EC
Sbjct: 835 FDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH-----STECGG 889
Query: 149 --QNYTTPSGVIKSPGFPE-KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
+ + P + F + YP ++C +++ + + S + L F++F++E +++
Sbjct: 890 RLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEAD------ 943
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
C YD +E++DG +GR+CG P I S + + F+TD I K+GF Y +
Sbjct: 944 CGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
Query: 266 Q 266
+
Sbjct: 1004 R 1004
>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
Length = 415
Score = 141 bits (356), Expect = 2e-33
Identities = 87/243 (35%), Positives = 135/243 (55%), Gaps = 17/243 (6%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDCKYD 85
CG + ES G++ S G+P Y P+ KC W I P+ + +++NF DLE D C+YD
Sbjct: 33 CGGILTGES-GFIGSEGFPGVYPPNSKCTWKITVPEG-KVVVLNFR-FIDLESDNLCRYD 89
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY---EIFK 142
+V+V++G + NG G+FCG P +VSSG + ++ +SD T G GF + E +
Sbjct: 90 FVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
Query: 143 RGPE-CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
RG + C PSG K+P +P++ YP + C + + APK I L+FE FD+E D+
Sbjct: 149 RGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDN-- 206
Query: 201 PGGMFCRYDRLEIWDGFP-DVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
+CRYD + +++G + IG+YCG P I S L + F +D ++ +GF
Sbjct: 207 ----YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262
Query: 260 ANY 262
+Y
Sbjct: 263 GHY 265
Score = 79.0 bits (193), Expect = 1e-14
Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 7/138 (5%)
Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
C T SG I S GFP YP + +CT+ + P+ ++L F DLE D+ C
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDN------LC 86
Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
RYD +++++G + G IGR+CG PG + SS + + +D+ A GF A +S +
Sbjct: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
Query: 267 SSVSEDFKCMEALGMESG 284
+ D C L SG
Sbjct: 146 PNERGDQYCGGLLDRPSG 163
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 139 bits (351), Expect = 6e-33
Identities = 80/236 (33%), Positives = 124/236 (52%), Gaps = 13/236 (5%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG+T++ ++ G ++PG+P+ Y C W I P ++I++NF + R C YDY
Sbjct: 351 CGETLQ-DTTGNFSAPGFPNGYPSYSHCVWRISVT-PGEKIVLNFTSMDLFKSRLCWYDY 408
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
VEV DG G+FCG P P+VS+ L+++F S G GF YE
Sbjct: 409 VEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYE-----AT 463
Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
C + +G I+SP +P+ Y S EC + + + + L F++F++E + C
Sbjct: 464 CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDS------C 517
Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
YD LE+ DG + IG +CG + P ++SSS L M F +D +I K GF+AN+
Sbjct: 518 AYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF 573
Score = 135 bits (339), Expect = 2e-31
Identities = 92/278 (33%), Positives = 131/278 (47%), Gaps = 54/278 (19%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
CG + ++ G + SP YP Y PS++C W I + + + + F F++E D C YD
Sbjct: 464 CGGDMNKDA-GQIQSPNYPDDYRPSKECVWRITVSEGFH-VGLTFQA-FEIERHDSCAYD 520
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Y+EV DG E G FCG P V SS L++KFVSD + AGF+ + FK
Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF--FKEVD 578
Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
ECS T +G I SPG+P+
Sbjct: 579 ECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPK 638
Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGF-PDVGPHI 224
+YP + C + V AP I L+FE F+LE G C+YD +E+ G PD H
Sbjct: 639 EYPTNKNCVWQVVAPAQYRISLQFEVFELE------GNDVCKYDFVEVRSGLSPDAKLH- 691
Query: 225 GRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
GR+CG +TP I S S + + F +D+ ++K GF A++
Sbjct: 692 GRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHF 729
Score = 131 bits (329), Expect = 2e-30
Identities = 89/329 (27%), Positives = 142/329 (43%), Gaps = 71/329 (21%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
G +TSPG+P Y ++ C W + AP Y RI + F F+LE D CKYD+VEV G +
Sbjct: 629 GTITSPGWPKEYPTNKNCVWQVVAPAQY-RISLQFEV-FELEGNDVCKYDFVEVRSGLSP 686
Query: 96 NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIR------------------ 137
+ G+FCG P + S + ++F SD GF
Sbjct: 687 DAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHE 746
Query: 138 ---------------YEIFKRGPECSQ-----NYTTPSGVIKSPGFPEKYPNSLECTYIV 177
Y + + G +C + ++ G + SP +P+KYP+ ECT+ +
Sbjct: 747 CVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNI 806
Query: 178 FAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIR 237
+ + L F F++E C YD LE++DG + P +GR+CG K P
Sbjct: 807 SSTAGHRVKLTFNEFEIEQHQE------CAYDHLEMYDGPDSLAPILGRFCGSKKPDPTV 860
Query: 238 SSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQY 297
+S + + FY+D+++ ++GF A +S E G E+ + ++ + +Q+
Sbjct: 861 ASGSSMFLRFYSDASVQRKGFQAVHST------------ECGGRLKAEVQTKELYSHAQF 908
Query: 298 STNWSAERSRLNYPENG---WT-PGEDSY 322
N NYP W ED Y
Sbjct: 909 GDN--------NYPSEARCDWVIVAEDGY 929
Score = 120 bits (300), Expect = 5e-27
Identities = 72/240 (30%), Positives = 116/240 (48%), Gaps = 11/240 (4%)
Query: 26 KCGDTIKIES-PGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLED-RDCK 83
+ G KI S G L SP +P Y +C W I + + R+ + FN F++E ++C
Sbjct: 773 EAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGH-RVKLTFN-EFEIEQHQECA 830
Query: 84 YDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
YD++E++DG + G+FCG P P V+SG +F++F SD GF + +
Sbjct: 831 YDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHST-EC 889
Query: 144 GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
G T + YP+ C +++ A + L F +F++E +++
Sbjct: 890 GGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEAD---- 945
Query: 204 MFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYS 263
C YD +E +DG+ P +GR+CG I S+ L + F TD I K+GF A Y+
Sbjct: 946 --CGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYT 1003
Score = 69.3 bits (168), Expect = 1e-11
Identities = 42/144 (29%), Positives = 65/144 (45%), Gaps = 15/144 (10%)
Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
P C + +G +PGFP YP+ C + + +I+L F S DL
Sbjct: 349 PACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFK------SR 402
Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
C YD +E+ DG+ P +GR+CG K P + S+ L + F + S I +GF A Y
Sbjct: 403 LCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAY-- 460
Query: 265 LQSSVSEDFKCMEALGMESGEIHS 288
+ C + ++G+I S
Sbjct: 461 -------EATCGGDMNKDAGQIQS 477
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 139 bits (350), Expect = 8e-33
Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG+T++ +S G +SP YP+ Y C W I P ++I++NF R C YDY
Sbjct: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
VEV DG RG+FCG P P+VS+ L+++F S G GF YE
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
C + G I+SP +P+ Y S C + + + + L F+SF++E + C
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
YD LE+ DG + IGRYCG + P I+S+S L + F +D +I K GF+ N+
Sbjct: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Score = 129 bits (323), Expect = 1e-29
Identities = 82/277 (29%), Positives = 132/277 (47%), Gaps = 52/277 (18%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
CG +K + G++ SP YP Y PS+ C W IQ + + + + F F++E D C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Y+EV DG +E+ G++CG P + S+ L++KFVSD + AGF++ + FK
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
ECS+ T +G I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
+YP + C + + AP I L+F+ F+ E G C+YD +E+ G G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
Query: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
++CG + P I S + + F +D+ ++K+GF A++
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 72.8 bits (177), Expect = 9e-13
Identities = 41/108 (37%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
G +TSPG+P Y P++ C W + AP Y RI + F+ F+ E D CKYD+VEV G
Sbjct: 600 GSITSPGWPKEYPPNKNCIWQLVAPTQY-RISLQFD-FFETEGNDVCKYDFVEVRSGLTA 657
Query: 96 NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
+ GKFCG P + S + ++F SD GF + KR
Sbjct: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKR 705
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)
Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
P C + +G SP +P Y + C + + +IIL F S DL
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
C YD +E+ DGF P GR+CG K P I S+ L + F + S +GF A Y +
Sbjct: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
Query: 264 VLQSSVSEDF 273
+ V +D+
Sbjct: 434 ICGGDVKKDY 443
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 139 bits (350), Expect = 8e-33
Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG+T++ +S G +SP YP+ Y C W I P ++I++NF R C YDY
Sbjct: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
VEV DG RG+FCG P P+VS+ L+++F S G GF YE
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
C + G I+SP +P+ Y S C + + + + L F+SF++E + C
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
YD LE+ DG + IGRYCG + P I+S+S L + F +D +I K GF+ N+
Sbjct: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Score = 130 bits (326), Expect = 5e-30
Identities = 85/284 (29%), Positives = 137/284 (48%), Gaps = 53/284 (18%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
CG +K + G++ SP YP Y PS+ C W IQ + + + + F F++E D C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Y+EV DG +E+ G++CG P + S+ L++KFVSD + AGF++ + FK
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
ECS+ T +G I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
+YP + C + + AP I L+F+ F+ E G C+YD +E+ G G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
Query: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN-YSVLQSS 268
++CG + P I S + + F +D+ ++K+GF A+ +SVL+ +
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)
Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
P C + +G SP +P Y + C + + +IIL F S DL
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
C YD +E+ DGF P GR+CG K P I S+ L + F + S +GF A Y +
Sbjct: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
Query: 264 VLQSSVSEDF 273
+ V +D+
Sbjct: 434 ICGGDVKKDY 443
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 139 bits (350), Expect = 8e-33
Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG+T++ +S G +SP YP+ Y C W I P ++I++NF R C YDY
Sbjct: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
VEV DG RG+FCG P P+VS+ L+++F S G GF YE
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434
Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
C + G I+SP +P+ Y S C + + + + L F+SF++E + C
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488
Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
YD LE+ DG + IGRYCG + P I+S+S L + F +D +I K GF+ N+
Sbjct: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544
Score = 132 bits (332), Expect = 1e-30
Identities = 82/268 (30%), Positives = 126/268 (47%), Gaps = 51/268 (19%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
G +TSPG+P Y P++ C W + AP Y RI + F+ F+ E D CKYD+VEV G
Sbjct: 600 GSITSPGWPKEYPPNKNCIWQLVAPTQY-RISLQFD-FFETEGNDVCKYDFVEVRSGLTA 657
Query: 96 NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQN----- 150
+ GKFCG P + S + ++F SD GF + F ECS++
Sbjct: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF--FSDKDECSKDNGGCQ 715
Query: 151 -----------------------------------YTTPSGVIKSPGFPEKYPNSLECTY 175
T+ SG I SP +P+KYP+ ECT+
Sbjct: 716 QDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTW 775
Query: 176 IVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGR 235
+ + + L F D+E S P C YD LE++DG P +GR+CG K P
Sbjct: 776 AISSTPGHRVKLTFMEMDIE--SQPE----CAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829
Query: 236 IRSSSGILSMVFYTDSAIAKEGFSANYS 263
+ ++ + + FY+D+++ ++GF A+++
Sbjct: 830 VLATGSRMFLRFYSDNSVQRKGFQASHA 857
Score = 130 bits (327), Expect = 4e-30
Identities = 67/228 (29%), Positives = 119/228 (52%), Gaps = 10/228 (4%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKYDYVEVFDGENE 95
G +TSP +P Y ++C W I + P R+ + F D+E + +C YD++EVFDG +
Sbjct: 756 GTITSPNWPDKYPSKKECTWAISST-PGHRVKLTFM-EMDIESQPECAYDHLEVFDGRDA 813
Query: 96 NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPS 155
G+FCG P PV+++G +F++F SD GF + + G + + T
Sbjct: 814 KAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHAT-ECGGQVRADVKTKD 872
Query: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWD 215
+ YP ++C +++ A + + L F++F++E +++ C YD +E++D
Sbjct: 873 LYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETD------CGYDYMELFD 926
Query: 216 GFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYS 263
G+ P +GRYCG P + S+ + + F++D I K+GF Y+
Sbjct: 927 GYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYT 974
Score = 130 bits (326), Expect = 5e-30
Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 52/287 (18%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
CG +K + G++ SP YP Y PS+ C W IQ + + + + F F++E D C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Y+EV DG +E+ G++CG P + S+ L++KFVSD + AGF++ + FK
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549
Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
ECS+ T +G I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609
Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
+YP + C + + AP I L+F+ F+ E G C+YD +E+ G G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663
Query: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSED 272
++CG + P I S + + F +D+ ++K+GF A++ + S+D
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKD 710
Score = 62.4 bits (150), Expect = 1e-09
Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)
Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
P C + +G SP +P Y + C + + +IIL F S DL
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373
Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
C YD +E+ DGF P GR+CG K P I S+ L + F + S +GF A Y +
Sbjct: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433
Query: 264 VLQSSVSEDF 273
+ V +D+
Sbjct: 434 ICGGDVKKDY 443
>gi|105990535 coagulation factor V precursor [Homo sapiens]
Length = 2224
Score = 138 bits (347), Expect = 2e-32
Identities = 105/331 (31%), Positives = 161/331 (48%), Gaps = 28/331 (8%)
Query: 272 DFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNY--PENGWT----PGEDSYREW 325
D C +G+ +G I QI AS ++ W +RLN N W+ E + + W
Sbjct: 1904 DRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPW 1962
Query: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKP---VLFQ 382
IQVD+ +T + TQGA K K Y + + SSN +W K GN + F
Sbjct: 1963 IQVDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFK-GNSTRNVMYFN 2019
Query: 383 GNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLI 442
GN++ + + F P++ R++RI P ++R E+ GC++ CS LGM +G I
Sbjct: 2020 GNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKI 2077
Query: 443 SDSQITSSN-----QGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
+ QIT+S+ GD W P RL + W A + +WL+IDL + K +
Sbjct: 2078 ENKQITASSFKKSWWGDY-WEPFRARLNAQGRVNAWQ---AKANNNKQWLEIDLLKIKKI 2133
Query: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
II QG K ++++++ + I YS G +WK S K FEGN N F
Sbjct: 2134 TAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFN 2193
Query: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEV 585
P + +RFIR+ P + + + LR+EL GC++
Sbjct: 2194 PPIISRFIRVIP-KTWNQSIALRLELFGCDI 2223
Score = 91.3 bits (225), Expect = 3e-18
Identities = 61/176 (34%), Positives = 94/176 (53%), Gaps = 10/176 (5%)
Query: 426 ITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVT--SRSGWALPPAPHSYINE 483
I D C +G+ +G+ISDSQI +S + W P RL S + W++ + ++
Sbjct: 1902 IMDRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASK 1960
Query: 484 -WLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEG 542
W+Q+D+ +E I+ GI QG KH + +F + YS+N +W++ +S R F G
Sbjct: 1961 PWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNG 2020
Query: 543 NNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNG 597
N++ T + F P + R+IRI P RA + LR+EL GCEV G +TP G
Sbjct: 2021 NSDASTIKENQFDPPIVARYIRISPTRA-YNRPTLRLELQGCEVN----GCSTPLG 2071
>gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo
sapiens]
Length = 775
Score = 138 bits (347), Expect = 2e-32
Identities = 123/444 (27%), Positives = 189/444 (42%), Gaps = 70/444 (15%)
Query: 7 LLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQR 66
LL VL L+L AGA + D CG T+ G LTS YP +Y S CEW I+ +R
Sbjct: 52 LLLLVLLLLLEDAGAQQGDGCGHTVLGPESGTLTSINYPQTYPNSTVCEWEIRVKMG-ER 110
Query: 67 IMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAPP--PVVSSGPFLFIKF 123
+ I F FD+ED D C ++Y+ +++G + GK+CG + S G + + F
Sbjct: 111 VRIKFGD-FDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIESKGNEITLLF 169
Query: 124 VSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMS 183
+S G GF Y + + + + C
Sbjct: 170 MSGIHVSGRGFLASYSVIDK------------------------QDLITC---------- 195
Query: 184 EIILEFESFDLEPDSNP--PGGMFCRYDRLE--IWDGFPDVGPHIGRYCGQKTPGRIRSS 239
L+ S LEP+ + P G + + I G+ D P C + S+
Sbjct: 196 ---LDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSP----LCMAGVHAGVVSN 248
Query: 240 S--GILSMVFYTDSAIAKEGFSANYSVLQSSVSED---FK---CMEALGMESGEIHSDQI 291
+ G +S+V + + N + + +S FK C LGMESG I QI
Sbjct: 249 TLGGQISVVISKGIPYYESSLANNVTSVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQI 308
Query: 292 TASSQYS--------TNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 343
TASS +W +++RL P W +W+Q+DL + +T + T G
Sbjct: 309 TASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTG 368
Query: 344 AISKETKKKYYVKTYKIDVSSNGEDWITIKEGN--KPVLFQGNTNPTDVVVAVFPKPLIT 401
+ E YYV Y+I S +G+ W +E + +FQGN + V F P+I
Sbjct: 369 STMVE--HNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIA 426
Query: 402 RFVRIKPATWETGISMRFEVYGCK 425
RF+R+ P W+ I+M+ E+ GC+
Sbjct: 427 RFIRVNPTQWQQKIAMKMELLGCQ 450
Score = 92.4 bits (228), Expect = 1e-18
Identities = 59/163 (36%), Positives = 86/163 (52%), Gaps = 13/163 (7%)
Query: 431 CSGMLGMVSGLISDSQITSSN-------QGDRN-WMPENIRLVTSRSGWALPPAPHSYIN 482
C G LGM SG+I+D QIT+S+ G N W P+ RL WA A Y
Sbjct: 292 CYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAF-ATDEY-- 348
Query: 483 EWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEG 542
+WLQIDL +EK + GII G E+ ++ ++I YS++G W + + + K F+G
Sbjct: 349 QWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQG 408
Query: 543 NNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCE 584
N +Y F P + RFIR+ P + + ++MELLGC+
Sbjct: 409 NKDYHQDVRNNFLPPIIARFIRVNPTQ-WQQKIAMKMELLGCQ 450
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 132 bits (332), Expect = 1e-30
Identities = 83/250 (33%), Positives = 123/250 (49%), Gaps = 20/250 (8%)
Query: 27 CGDTIKI---ESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDC 82
CG + I +S GY+TSP +PH+Y P C W++ AP P RI + F FD+E +C
Sbjct: 2217 CGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAP-PETRIQLQFEDRFDIEVTPNC 2275
Query: 83 KYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142
+Y+E+ DG + + KFCG P SSG ++++F SD GF +Y I
Sbjct: 2276 TSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI-- 2333
Query: 143 RGPECSQNYTTPSGVIKSPGFPE-KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPP 201
+C SGV++S G P Y ++L C + + + + FE F+L+ S
Sbjct: 2334 --AQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSG-- 2389
Query: 202 GGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN 261
C D +EIWD G +GRYCG P I +SS + F TD ++ GF
Sbjct: 2390 ----CEKDFVEIWDNHTS-GNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLR 2444
Query: 262 YSVLQSSVSE 271
+ +SS+ E
Sbjct: 2445 F---ESSMEE 2451
Score = 130 bits (326), Expect = 5e-30
Identities = 86/275 (31%), Positives = 123/275 (44%), Gaps = 19/275 (6%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CGD + E G + SP +P+ Y C W I P Q I++NF C+ DY
Sbjct: 817 CGDELTGE--GVIRSPFFPNVYPGERTCRWTIHQPQS-QVILLNFTVFEIGSSAHCETDY 873
Query: 87 VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
VE+ K+CG P + S FL++ FV T GF ++
Sbjct: 874 VEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSA--EDLA 931
Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
C + T +G I+SPG P YP+ + CT+ + I L FE+F LE N C
Sbjct: 932 CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN------C 985
Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
D LE++D D +GRYCG+ P + SS L +VF TDS +A EGF NY +
Sbjct: 986 TNDYLEVYD--TDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAIS 1043
Query: 267 SSVSEDFKCMEALGMESGEIHSDQITASSQYSTNW 301
++ + C++ + G S + Y NW
Sbjct: 1044 AATA----CLQDYTDDLGTFTSPNF--PNNYPNNW 1072
Score = 126 bits (317), Expect = 5e-29
Identities = 86/235 (36%), Positives = 114/235 (48%), Gaps = 11/235 (4%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKYD 85
CG+ I ES G + SPG+P+ Y C W I P I + F F LE +C D
Sbjct: 932 CGE-ILTESTGTIQSPGHPNVYPHGINCTWHILV-QPNHLIHLMFET-FHLEFHYNCTND 988
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
Y+EV+D ++E G++CGK PP + SSG L + FV+D + GF I YE
Sbjct: 989 YLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAAT 1046
Query: 146 ECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
C Q+YT G SP FP YPN+ EC Y + I + F +F LE G +
Sbjct: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLE---EAIGNYY 1103
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSA 260
D LEI DG + P +G + G P I S S L + F +D + GFSA
Sbjct: 1104 T--DFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSA 1156
Score = 126 bits (317), Expect = 5e-29
Identities = 77/238 (32%), Positives = 117/238 (49%), Gaps = 12/238 (5%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDCKYD 85
CG I S ++SP +P +Y ++ C W+IQA P I ++F HF+LE C D
Sbjct: 1620 CGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFT-HFELERSTTCARD 1678
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
+VE+ DG +E+ RG++CG P P+ S L ++FVSD GF +
Sbjct: 1679 FVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGF--HTTVTASVS 1736
Query: 146 ECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
C + G+ SPG+P+ YP ++EC + + + + + L F SF LE +
Sbjct: 1737 ACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQD------ 1790
Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSG-ILSMVFYTDSAIAKEGFSANY 262
C D +EI +G G +GRYCG P S G L + F +D + + GF A +
Sbjct: 1791 CSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATF 1847
Score = 116 bits (290), Expect = 7e-26
Identities = 81/255 (31%), Positives = 122/255 (47%), Gaps = 18/255 (7%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG + S G + SP YP Y + C W+I+ D R+++NF FDLE +D
Sbjct: 1510 CGGIFQAPS-GEIHSPNYPSPYRSNTDCSWVIRV-DRNHRVLLNFTD-FDLEPQD---SC 1563
Query: 87 VEVFDGENENGHFRGKFCGKIA-PPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
+ +DG + + CG+ P+VSSG LF++F S GF ++ G
Sbjct: 1564 IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGH 1623
Query: 146 ECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFA-PKMSEIILEFESFDLEPDSNPPGGM 204
+ ++ T + SP FP YPN+ C++I+ A P ++ I L F F+LE +
Sbjct: 1624 ILTSSFDT----VSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTT----- 1674
Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
C D +EI DG + P GRYCG P I S S L++ F +DS+I+ GF +
Sbjct: 1675 -CARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTA 1733
Query: 265 LQSSVSEDFKCMEAL 279
S+ F E +
Sbjct: 1734 SVSACGGTFYMAEGI 1748
Score = 112 bits (281), Expect = 8e-25
Identities = 76/245 (31%), Positives = 114/245 (46%), Gaps = 21/245 (8%)
Query: 27 CGDTIKI-ESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLED-RDCKY 84
CG ++ ++P +L SPG+P SY C WLIQAPD + I D+E R C Y
Sbjct: 1978 CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNIL---SLDIESHRTCAY 2034
Query: 85 DYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRG 144
D + + DG+N CG+ P P+ S+G ++FI+F SD AGF+ +
Sbjct: 2035 DSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFH----- 2089
Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
C G+I SP +PE YP++L C++ V I + FE +P P G
Sbjct: 2090 KSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFE----QPFQIPNGDS 2145
Query: 205 FCRY-DRLEIWDG----FPDVGP--HIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEG 257
C D L + +G P +GP G +CG + +S + + F +D + +G
Sbjct: 2146 SCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQG 2205
Query: 258 FSANY 262
F Y
Sbjct: 2206 FKIKY 2210
Score = 112 bits (281), Expect = 8e-25
Identities = 86/297 (28%), Positives = 131/297 (44%), Gaps = 39/297 (13%)
Query: 27 CGDTIKIESPGYLTSPGYP--HSYHPSEKCEWLIQAPDP-YQRIMINFNPHFDLEDRDCK 83
CG ++ G TSPGY +Y + CEW + P+ I I+F + +DC+
Sbjct: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQ 2629
Query: 84 YDYVEVFDGENENGHFRGKFCGKIAPP-PVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142
+D +E G+ + G + CG P P+V ++I FV++ GF +Y
Sbjct: 2630 FDVLEFRVGDAD-GPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSF-- 2686
Query: 143 RGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPG 202
+C SGVI SP +P Y + C+ ++ AP+ I L F FD+EP +
Sbjct: 2687 --TDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTT--- 2741
Query: 203 GMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
C +D + + +G P IG+YCG P I+S S L + F +D ++ GF A +
Sbjct: 2742 ---CAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATW 2798
Query: 263 SVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPEN---GWT 316
+ + LG G HSD T S + W N+PEN WT
Sbjct: 2799 NT------------QTLGC-GGIFHSDNGTIRSPH---WPQ-----NFPENSRCSWT 2834
Score = 111 bits (278), Expect = 2e-24
Identities = 96/351 (27%), Positives = 157/351 (44%), Gaps = 35/351 (9%)
Query: 27 CGDTIK-IESPGYLTSP--GYPHSYHPSEKCEWLIQAP-DPYQRIMINFNPHFDLEDRD- 81
CG+++ I SP GY H + C W+I+ RI F F LE D
Sbjct: 474 CGESLSGINGSFSYRSPDVGYVHDVN----CFWVIKTEMGKVLRITFTF---FRLESMDN 526
Query: 82 CKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIF 141
C +++++V+DG++ + G+FCG P ++SS L+ S++ +G GF++R+E
Sbjct: 527 CPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWE-- 584
Query: 142 KRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPP 201
+ PEC T P G IKSPG+P YP +C +IV + F + LE +
Sbjct: 585 TQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD-- 642
Query: 202 GGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN 261
C D LEI DG P +G++C + ++++ + F++DS I+ +GF
Sbjct: 643 ----CNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHIT 698
Query: 262 YSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNW-------SAERSRLNYPENG 314
Y S D +C GE+ +++ ++ E+ ++N+
Sbjct: 699 YLTSPS----DLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVE 754
Query: 315 WTPGEDSYREWIQVDLG--LLRFVTAVGTQGAISKETKKKYYVKTYKIDVS 363
DS + +I+V G LL V GT I T + +KID S
Sbjct: 755 LQCQSDSSQNYIEVRDGETLLGKVCGNGTISHIKSITNSVWI--RFKIDAS 803
Score = 110 bits (275), Expect = 4e-24
Identities = 77/255 (30%), Positives = 117/255 (45%), Gaps = 23/255 (9%)
Query: 17 APAGAFRND---KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNP 73
APA F +CG S GY+ SP YP Y + C ++I+A +P +++ F
Sbjct: 2907 APAQGFSASFVSRCGSNFTGPS-GYIISPNYPKQYDNNMNCTYVIEA-NPLSVVLLTF-V 2963
Query: 74 HFDLEDRD-----CKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYE 128
F LE R C D V + G + CG P P+ +GP L + F S+ +
Sbjct: 2964 SFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQ 3022
Query: 129 THGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFP-EKYPNSLECTYIVFAPKMSEIIL 187
GF Y I C + SG+I SP + YPN + C Y + I L
Sbjct: 3023 ITDFGFKFSYRIIS----CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIEL 3078
Query: 188 EFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVF 247
+F FD+ P ++ C +D L I+DG P +G++CG K P ++SS+ + +VF
Sbjct: 3079 KFSDFDVVPSTS------CSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVF 3132
Query: 248 YTDSAIAKEGFSANY 262
TDS +G+ ++
Sbjct: 3133 KTDSFQTAKGWKMSF 3147
Score = 110 bits (274), Expect = 5e-24
Identities = 72/250 (28%), Positives = 117/250 (46%), Gaps = 11/250 (4%)
Query: 21 AFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEK-CEWLIQAPDPYQRIMINFNPHFDLED 79
++R CG S G +TSP Y ++ +P++ C + I D + I + F+ +
Sbjct: 3031 SYRIISCGGVFNFSS-GIITSPAYSYADYPNDMHCLYTITVSDD-KVIELKFSDFDVVPS 3088
Query: 80 RDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE 139
C +DY+ ++DG N + GKFCG PP V SS + + F +D G+ + +
Sbjct: 3089 TSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFR 3148
Query: 140 IFKRGPE--CSQNYTTPSGVIKSPGFPEK--YPNSLECTYIVFAPKMSEIILEFESFDLE 195
GP+ C T + SP Y +L C +I+ AP I L F +F LE
Sbjct: 3149 Q-TLGPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALE 3207
Query: 196 PDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAK 255
S C YD ++++DG + G +CG P SS L++ F +D + +
Sbjct: 3208 AASTRQR---CLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLER 3264
Query: 256 EGFSANYSVL 265
EGF+A Y+++
Sbjct: 3265 EGFNATYTIM 3274
Score = 109 bits (272), Expect = 9e-24
Identities = 79/235 (33%), Positives = 116/235 (49%), Gaps = 19/235 (8%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLED-RDCKYD 85
CG T + + G SPGYP Y P+ +C W I + P R+ ++F F LED +DC D
Sbjct: 1738 CGGTFYM-AEGIFNSPGYPDIYPPNVECVWNIVS-SPGNRLQLSFIS-FQLEDSQDCSRD 1794
Query: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSS-GPFLFIKFVSDYETHGAGFSIRY-EIFKR 143
+VE+ +G N GH G++CG P S G L+++F+SD G GF + +IF
Sbjct: 1795 FVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFG- 1852
Query: 144 GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
+ N G + SP +PE YP++ + V + D+E N
Sbjct: 1853 ----NDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQN---- 1904
Query: 204 MFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGF 258
C YD+L I+DG IG YCG +T S+ L+ FY+DS+I+ +GF
Sbjct: 1905 --CYYDKLRIYDGPSIHARLIGAYCGTQTES-FSSTGNSLTFHFYSDSSISGKGF 1956
Score = 108 bits (271), Expect = 1e-23
Identities = 75/258 (29%), Positives = 118/258 (45%), Gaps = 32/258 (12%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKY-- 84
CG + + G +TSP YP +Y + C W + I ++F F + + D
Sbjct: 2092 CGGYLHADR-GIITSPKYPETYPSNLNCSWHVLVQSGLT-IAVHFEQPFQIPNGDSSCNQ 2149
Query: 85 -DYVEVFDGEN----------ENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAG 133
DY+ + +G + NGHF CG A + +S +F++F+SD+ G G
Sbjct: 2150 GDYLVLRNGPDICSPPLGPPGGNGHF----CGSHASSTLFTSDNQMFVQFISDHSNEGQG 2205
Query: 134 FSIRYEIFKRGPECSQNY----TTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEF 189
F I+YE + C N +G + SP P YP +C +I+ AP + I L+F
Sbjct: 2206 FKIKYE--AKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQF 2263
Query: 190 ES-FDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFY 248
E FD+E N C + LE+ DG P + ++CG P SS ++ + F
Sbjct: 2264 EDRFDIEVTPN------CTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFR 2317
Query: 249 TDSAIAKEGFSANYSVLQ 266
+D++ GF A YS+ Q
Sbjct: 2318 SDNSPTHVGFKAKYSIAQ 2335
Score = 107 bits (267), Expect = 3e-23
Identities = 65/228 (28%), Positives = 101/228 (44%), Gaps = 11/228 (4%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENEN 96
G + SPGYP +Y P C W++ P + F DC DY+E+ DG
Sbjct: 599 GSIKSPGYPGNYPPGRDCVWIV-VTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQ 657
Query: 97 GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSG 156
GKFC + PP+ ++GPF I F SD + GF I Y C NYT P G
Sbjct: 658 DPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEG 717
Query: 157 VIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG 216
+ P + ++ +C Y++ P+ +I + F +L+ C+ D + +
Sbjct: 718 ELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQ----------CQSDSSQNYIE 767
Query: 217 FPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
D +G+ CG T I+S + + + F D+++ K F A Y V
Sbjct: 768 VRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQV 815
Score = 103 bits (258), Expect = 4e-22
Identities = 74/248 (29%), Positives = 112/248 (45%), Gaps = 34/248 (13%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD----- 81
CG + S G SP YP Y+ S +C W +++ + F+LE +D
Sbjct: 1165 CGGNLTTSS-GTFISPNYPMPYYHSSECYWWLKS---------SHGSAFELEFKDFHLEH 1214
Query: 82 ---CKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY 138
C DY+ V+DG + N H + CG PP + SSG +FIK +D G GF Y
Sbjct: 1215 HPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274
Query: 139 -EIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPD 197
+ + +Q Y G+++S G+P Y + C + + A + + F +FDLE
Sbjct: 1275 RQTCENVVIVNQTY----GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHH 1330
Query: 198 SNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKE- 256
N C D LE++DG +GRYCG P ++S L ++ TD +E
Sbjct: 1331 IN------CSTDYLELYDG----PRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREK 1380
Query: 257 GFSANYSV 264
GF + V
Sbjct: 1381 GFQMQWFV 1388
Score = 103 bits (258), Expect = 4e-22
Identities = 69/235 (29%), Positives = 112/235 (47%), Gaps = 15/235 (6%)
Query: 27 CGDTIKIE-SPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYD 85
CG T +P ++SP P C W+I +P P+Q++ I L +DC +
Sbjct: 3278 CGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSP-PHQQVKITVWA-LQLTSQDCTQN 3335
Query: 86 YVEVFDGENENGHFRGKFCGKIAP--PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
Y+++ D +G+ R +FCG+ A P SS + F S + S Y+I
Sbjct: 3336 YLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQI--- 3392
Query: 144 GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
+C+++Y G ++SPG+P+ Y N +CT + AP+ I L F S +E
Sbjct: 3393 -ADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIE------NS 3445
Query: 204 MFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGF 258
+ CR D LE+ +G P +G+YCG P + S + L + F +DS + G+
Sbjct: 3446 VECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY 3500
Score = 103 bits (257), Expect = 5e-22
Identities = 79/250 (31%), Positives = 119/250 (47%), Gaps = 17/250 (6%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKY--DYVEVFDGEN 94
G TSP +P++Y + +C + I Q I ++F +F LE+ Y D++E+ DG
Sbjct: 1057 GTFTSPNFPNNYPNNWECIYRITVRTG-QLIAVHFT-NFSLEEAIGNYYTDFLEIRDGGY 1114
Query: 95 ENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTP 154
E G F G PP ++S L++KF SD +GFS ++ G C N TT
Sbjct: 1115 EKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTG--CGGNLTTS 1172
Query: 155 SGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIW 214
SG SP +P Y +S EC + + + S LEF+ F LE N C D L ++
Sbjct: 1173 SGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPN------CTLDYLAVY 1226
Query: 215 DGFPDVGPH-IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSS---VS 270
DG P H + + CG + P IRSS + + TD GF A Y + V+
Sbjct: 1227 DG-PSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIVN 1285
Query: 271 EDFKCMEALG 280
+ + +E++G
Sbjct: 1286 QTYGILESIG 1295
Score = 101 bits (251), Expect = 2e-21
Identities = 68/242 (28%), Positives = 115/242 (47%), Gaps = 14/242 (5%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD--CKY 84
CG ++ G + SP +P ++ + +C W + + I+F+ +F + D C+
Sbjct: 2805 CGGIFHSDN-GTIRSPHWPQNFPENSRCSWTA-ITHKSKHLEISFDNNFLIPSGDGQCQN 2862
Query: 85 DYVEVFDGENE-NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
+V+V+ G E + CG +AP PV++ F S E GFS +
Sbjct: 2863 SFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFV---- 2917
Query: 144 GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
C N+T PSG I SP +P++Y N++ CTY++ A +S ++L F SF LE S G
Sbjct: 2918 -SRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGS 2976
Query: 204 MFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYS 263
C D + I G+ + CG + P + + +L + FY++ I GF +Y
Sbjct: 2977 --CVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYR 3033
Query: 264 VL 265
++
Sbjct: 3034 II 3035
Score = 99.4 bits (246), Expect = 9e-21
Identities = 66/241 (27%), Positives = 116/241 (48%), Gaps = 20/241 (8%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
CG + + G +SPG+P+ Y P+++C W I+ DP I + + FD+E C +D
Sbjct: 1391 CGGELS-GATGSFSSPGFPNRYPPNKECIWYIRT-DPGSSIQLTIHD-FDVEYHSRCNFD 1447
Query: 86 YVEVFDGENENGHFRGKFCGKIAPP---PVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142
+E++ G + + + C + +P V S+G L I+F +D +G GF+ ++
Sbjct: 1448 VLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVT 1507
Query: 143 RGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPG 202
G C + PSG I SP +P Y ++ +C++++ + ++L F FDLEP +
Sbjct: 1508 GG--CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDS--- 1562
Query: 203 GMFCRYDRLEIWDGFPDVGPHIGRYCG-QKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN 261
C + +DG + R CG ++ I SS L + F + + GF A
Sbjct: 1563 ---C----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQ 1615
Query: 262 Y 262
+
Sbjct: 1616 F 1616
Score = 97.4 bits (241), Expect = 4e-20
Identities = 66/223 (29%), Positives = 101/223 (45%), Gaps = 10/223 (4%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENEN 96
G L SPG+P +Y + C + AP + I + F+ +C+ D++EV +G N N
Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHT-ISLFFHSLGIENSVECRNDFLEVRNGSNSN 3462
Query: 97 GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSG 156
GK+CG + P PV S L+++F SD T G+ I + G C G
Sbjct: 3463 SPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSG--CGGTLYGDRG 3520
Query: 157 VIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG 216
SPG+P YPN+ C +++ AP + + F ++ PG C + L ++DG
Sbjct: 3521 SFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISID----DPGD--CVQNYLTLYDG 3574
Query: 217 FPDVGPHIGRYCGQKTP-GRIRSSSGILSMVFYTDSAIAKEGF 258
P G YCG T +SS + + F+ D A F
Sbjct: 3575 PNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAF 3617
Score = 95.9 bits (237), Expect = 1e-19
Identities = 76/293 (25%), Positives = 133/293 (45%), Gaps = 22/293 (7%)
Query: 26 KCGDTIKIESPGYLTSPGYPH-SYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CK 83
+CG + +S G + S G+P Y + CEW +Q + + I+F F+L++ C+
Sbjct: 2335 QCGGRVPGQS-GVVESIGHPTLPYRDNLFCEWHLQGLSGHY-LTISFED-FNLQNSSGCE 2391
Query: 84 YDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
D+VE++D +G+ G++CG P + +S ++FV+D +GF +R+E
Sbjct: 2392 KDFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSME 2450
Query: 144 GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
EC + G SP +P P+ C + + AP+ I L F + L +
Sbjct: 2451 --ECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPS---- 2504
Query: 204 MFCRYDRLEIWDGFPDVGPHIGRYCGQ-KTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
C + + +++G P + + C I+SS + ++F+TD + GF+A+Y
Sbjct: 2505 --CNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY 2562
Query: 263 SVLQSSVSEDFKCMEAL-GMESGEIHSDQITASSQYSTNWSAERSRLNYPENG 314
+ SED C +L G S YS N + E + L+ P G
Sbjct: 2563 -----TSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWT-LSNPNQG 2609
Score = 89.0 bits (219), Expect = 1e-17
Identities = 64/242 (26%), Positives = 111/242 (45%), Gaps = 30/242 (12%)
Query: 37 GYLTSPGYPHSYHPSEKCEWLIQAPDPYQ---RIMINFNPHFDLED-RDCKYDYVEVFDG 92
G + SP +P +Y + +W + + RI+ D+E+ ++C YD + ++DG
Sbjct: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRIL-----EMDIEEIQNCYYDKLRIYDG 1915
Query: 93 ENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYT 152
+ + G +CG S+G L F SD G GF + + P+
Sbjct: 1916 PSIHARLIGAYCG-TQTESFSSTGNSLTFHFYSDSSISGKGFLLEW-FAVDAPDGVLPTI 1973
Query: 153 TPSG------------VIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
P + SPG+P+ Y N ++CT+++ AP S + L S D+E
Sbjct: 1974 APGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRT- 2031
Query: 201 PGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSA 260
C YD L I DG ++ + CG++ PG IRS+ + + F +DS++ + GF+A
Sbjct: 2032 -----CAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNA 2086
Query: 261 NY 262
++
Sbjct: 2087 SF 2088
Score = 80.5 bits (197), Expect = 4e-15
Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 22/211 (10%)
Query: 48 YHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD----CKYDYVEVFDGENENGHFRGKF 103
Y + C W+I AP + I + FN F LE C YDYV+++DG++EN + G F
Sbjct: 3179 YDKNLNCVWIIIAP-VNKVIHLTFNT-FALEAASTRQRCLYDYVKLYDGDSENANLAGTF 3236
Query: 104 CGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGF 163
CG P P +SSG FL ++F+SD GF+ Y I + N T I SP
Sbjct: 3237 CGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNS 3296
Query: 164 PEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPH 223
+ CT+++ +P ++ + + L C + L++ D G
Sbjct: 3297 SDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-------CTQNYLQLQDSPQGHGNS 3349
Query: 224 IGRYCGQKTPGRIRSSSGILSMVFYTDSAIA 254
++CG R++S + VFY+ + A
Sbjct: 3350 RFQFCG-------RNASAV--PVFYSSMSTA 3371
Score = 78.2 bits (191), Expect = 2e-14
Identities = 71/245 (28%), Positives = 103/245 (42%), Gaps = 15/245 (6%)
Query: 25 DKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKY 84
++CG ++ S G TSP YP+ CEW I AP+ +RI + FN C
Sbjct: 2450 EECGGDLQ-GSIGTFTSPNYPNPNPHGRICEWRITAPEG-RRITLMFNNLRLATHPSCNN 2507
Query: 85 DYVEVFDGENENGHFRGKFCGKI-APPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
++V VF+G N K C + + SSG + + F +D GF+ Y +
Sbjct: 2508 EHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED 2567
Query: 144 GPECSQNYTTPSGVIKSPGFP--EKYPNSLECTYIVFAPKM--SEIILEFESFDLEPDSN 199
TP G SPG+ Y +L C + + P S I + FE F LE +
Sbjct: 2568 AVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQD 2627
Query: 200 PPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPG-RIRSSSGILSMVFYTDSAIAKEGF 258
C++D LE G D GP + R CG P + + + F T+ + GF
Sbjct: 2628 ------CQFDVLEFRVGDAD-GPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGF 2680
Query: 259 SANYS 263
A YS
Sbjct: 2681 HAKYS 2685
Score = 64.3 bits (155), Expect = 3e-10
Identities = 38/114 (33%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
CG T+ + G TSPGYP +Y + CEW++ AP + + INF + DC +Y
Sbjct: 3511 CGGTLYGDR-GSFTSPGYPGTYPNNTYCEWVLVAPAG-RLVTINFYFISIDDPGDCVQNY 3568
Query: 87 VEVFDGENENGHFRGKFCG-KIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE 139
+ ++DG N + G +CG + P V+S +FIKF +DY + F + ++
Sbjct: 3569 LTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWD 3622
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 130 bits (328), Expect = 3e-30
Identities = 88/261 (33%), Positives = 128/261 (49%), Gaps = 23/261 (8%)
Query: 9 CAVLALVLAPAG----AFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPY 64
C +LA+ L G A KCG + S G +SP +P Y + +C WLI +
Sbjct: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPS-GNFSSPNFPRLYPYNTECSWLIVVAEG- 65
Query: 65 QRIMINFNPHFDLEDRD-CKYDYVEVFDGEN-ENGHFRGKFCGKIAPPPVVSSGPFLFIK 122
+++ F+ FDLE D C +D++E+++G + + G+ G+FCGK+ PPP SS + +
Sbjct: 66 SSVLLTFHA-FDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVI 124
Query: 123 FVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKM 182
F SD GFS Y+ C T SGV+ SP +P YPNS+EC +++ A
Sbjct: 125 FHSDKHVASHGFSAGYQ----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGP 180
Query: 183 SEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG-RYCGQKTPGRIRSSSG 241
+ + L F F +E G C YD + + G GP G YCG P + S
Sbjct: 181 AHVKLVFVDFQVE------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGH 231
Query: 242 ILSMVFYTDSAIAKEGFSANY 262
L +VF +D I GF A Y
Sbjct: 232 ELQVVFKSDFNIGGRGFKAYY 252
Score = 129 bits (323), Expect = 1e-29
Identities = 79/246 (32%), Positives = 120/246 (48%), Gaps = 14/246 (5%)
Query: 19 AGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE 78
+ ++ D CG + S G LTSP YP++Y S +C W+I+A P ++ + F +E
Sbjct: 137 SAGYQKDVCGGVLTGLS-GVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD--FQVE 193
Query: 79 -DRDCKYDYVEVFDGENEN-GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSI 136
+ +C YDYV V G GH +CG PP +VS G L + F SD+ G GF
Sbjct: 194 GNEECTYDYVAVLGGPGPTRGHH---YCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
Query: 137 RYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEP 196
Y EC + Y G SP +P YPN++ C + + P ++ + F DLE
Sbjct: 251 YYF----SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEE 306
Query: 197 DSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKE 256
++ C +D L +DG + P +G +CG P + SS L ++ +TD + +
Sbjct: 307 PNSLT--KTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRR 364
Query: 257 GFSANY 262
GFS Y
Sbjct: 365 GFSVAY 370
>gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Homo
sapiens]
Length = 335
Score = 115 bits (287), Expect = 2e-25
Identities = 107/353 (30%), Positives = 158/353 (44%), Gaps = 81/353 (22%)
Query: 246 VFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYST-----N 300
VF + + +G++ N+ + KC+E LG+E+G I + QI ASS T +
Sbjct: 49 VFPSYTCTCLKGYAGNHC--------ETKCVEPLGLENGNIANSQIAASSVRVTFLGLQH 100
Query: 301 WSAERSRLNYPE--NGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTY 358
W E +RLN N WTP + WIQV+L +VT V TQGA + + Y+K +
Sbjct: 101 WVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHE--YLKAF 158
Query: 359 KIDVSSNGEDWITIKEGNKPVL-FQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISM 417
K+ S NG ++ I + NK F GN N V V +F P+ ++VR+ P + T ++
Sbjct: 159 KVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTL 218
Query: 418 RFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDR------NWMPENIRLVTSRSGW 471
RFE+ GC++ C+ LG+ + I D QIT+S+ +W P RL + G
Sbjct: 219 RFELLGCELNG--CANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARL--DKQGN 274
Query: 472 ALPPAPHSYIN-EWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIM 530
SY N +WLQI G +W
Sbjct: 275 FNAWVAGSYGNDQWLQIFPG----------------------------------NW---- 296
Query: 531 DDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGC 583
D+ K N ++TP L R++RI P A H + LR+ELLGC
Sbjct: 297 DNHSHK------KNLFETPIL-------ARYVRILPV-AWHNRIALRLELLGC 335
Score = 82.8 bits (203), Expect = 9e-16
Identities = 61/189 (32%), Positives = 95/189 (50%), Gaps = 15/189 (7%)
Query: 431 CSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSRSGWALPPAPHSYI-NEW 484
C LG+ +G I++SQI +S+ G ++W+PE RL +R+G P S N W
Sbjct: 70 CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARL--NRAGMVNAWTPSSNDDNPW 127
Query: 485 LQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNN 544
+Q++L V G++ QG + +++ FK+ YS NG ++ I D +K K K F GN
Sbjct: 128 IQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNK-KHKEFVGNW 186
Query: 545 NYDTPELRTFPA-LSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDEC 603
N + + F + +++R+YP + H LR ELLGCE+ G P G +
Sbjct: 187 NKNAVHVNLFETPVEAQYVRLYP-TSCHTACTLRFELLGCELN----GCANPLGLKNNSI 241
Query: 604 DDDQANCHS 612
D Q S
Sbjct: 242 PDKQITASS 250
>gi|10518506 coagulation factor VIII isoform b precursor [Homo
sapiens]
Length = 216
Score = 113 bits (283), Expect = 5e-25
Identities = 70/211 (33%), Positives = 111/211 (52%), Gaps = 10/211 (4%)
Query: 380 LFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVS 439
+F GN + + + +F P+I R++R+ P + ++R E+ GC + CS LGM S
Sbjct: 9 VFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMES 66
Query: 440 GLISDSQITSSNQGDR---NWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVR 496
ISD+QIT+S+ W P RL A P ++ EWLQ+D + V
Sbjct: 67 KAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNP-KEWLQVDFQKTMKVT 125
Query: 497 GIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-P 555
G+ QG K +++++F I S +G W + + K K F+GN + TP + + P
Sbjct: 126 GVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNG--KVKVFQGNQDSFTPVVNSLDP 183
Query: 556 ALSTRFIRIYPERATHGGLGLRMELLGCEVE 586
L TR++RI+P+ H + LRME+LGCE +
Sbjct: 184 PLLTRYLRIHPQSWVH-QIALRMEVLGCEAQ 213
Score = 103 bits (257), Expect = 5e-22
Identities = 62/159 (38%), Positives = 83/159 (52%), Gaps = 7/159 (4%)
Query: 275 CMEALGMESGEIHSDQITASSQYST---NWSAERSRLNYP--ENGWTPGEDSYREWIQVD 329
C LGMES I QITASS ++ WS ++RL+ N W P ++ +EW+QVD
Sbjct: 58 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 117
Query: 330 LGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTD 389
VT V TQG S T YVK + I S +G W + K +FQGN +
Sbjct: 118 FQKTMKVTGVTTQGVKSLLTSM--YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 175
Query: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITD 428
VV PL+TR++RI P +W I++R EV GC+ D
Sbjct: 176 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 214
>gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo
sapiens]
Length = 539
Score = 110 bits (275), Expect = 4e-24
Identities = 109/438 (24%), Positives = 190/438 (43%), Gaps = 62/438 (14%)
Query: 11 VLALVLAPAGAFR------NDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPY 64
+LAL+LA + R D CG + + G +TS YP +Y CE I P
Sbjct: 19 LLALLLAVSAPLRLQAEELGDGCGHLVTYQDSGTMTSKNYPGTYPNHTVCEKTITVPKG- 77
Query: 65 QRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIA-PPPVVSSGPFLFIKF 123
+R+++ D+E + C DY+ +F ++ G +CG + P ++ + + ++F
Sbjct: 78 KRLILRLGD-LDIESQTCASDYL-LFTSSSDQ---YGPYCGSMTVPKELLLNTSEVTVRF 132
Query: 124 VSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMS 183
S G GF + Y S ++ + E+ + L+ Y F P
Sbjct: 133 ESGSHISGRGFLLTY--------ASSDHPDLITCL------ERASHYLKTEYSKFCPAGC 178
Query: 184 EIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGIL 243
+ S ++ D + C+ I G + +G I GIL
Sbjct: 179 RDVAGDISGNMV-DGYRDTSLLCK---AAIHAGI--IADELGGQISVLQRKGISRYEGIL 232
Query: 244 SMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYST---- 299
+ + ++++G ++ L +S C +L E QI ASS + +
Sbjct: 233 A-----NGVLSRDGSLSDKRFLFTSNG----CSRSLSFEP----DGQIRASSSWQSVNES 279
Query: 300 ----NWSAERSRLNYPENGWTPGEDSY----REWIQVDLGLLRFVTAVGTQGAISKETKK 351
+WS ++RL W G+ S REW+++DLG + +T + T G S ++
Sbjct: 280 GDQVHWSPGQARLQDQGPSWASGDSSNNHKPREWLEIDLGEKKKITGIRTTG--STQSNF 337
Query: 352 KYYVKTYKIDVSSNGEDWITIKE--GNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPA 409
+YVK++ ++ +N W T K N+ +FQGN+N D V F P++ R+VR+ P
Sbjct: 338 NFYVKSFVMNFKNNNSKWKTYKGIVNNEEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQ 397
Query: 410 TWETGISMRFEVYGCKIT 427
TW I+++ E+ GC+IT
Sbjct: 398 TWHQRIALKVELIGCQIT 415
Score = 83.2 bits (204), Expect = 7e-16
Identities = 45/146 (30%), Positives = 76/146 (52%), Gaps = 4/146 (2%)
Query: 443 SDSQITSSNQGDR-NWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIII 500
S S + + GD+ +W P RL WA + +++ EWL+IDLGE+K + GI
Sbjct: 270 SSSWQSVNESGDQVHWSPGQARLQDQGPSWASGDSSNNHKPREWLEIDLGEKKKITGIRT 329
Query: 501 QGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-PALST 559
G +++ F + + NN S WK + K F+GN+N+ P F P +
Sbjct: 330 TGSTQSNFNFYVKSFVMNFKNNNSKWKTYKGIVNNEEKVFQGNSNFRDPVQNNFIPPIVA 389
Query: 560 RFIRIYPERATHGGLGLRMELLGCEV 585
R++R+ P+ H + L++EL+GC++
Sbjct: 390 RYVRVVPQ-TWHQRIALKVELIGCQI 414
>gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3
precursor [Homo sapiens]
Length = 533
Score = 102 bits (255), Expect = 8e-22
Identities = 67/237 (28%), Positives = 112/237 (47%), Gaps = 24/237 (10%)
Query: 26 KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKY 84
+CG K G TSP YP Y P +C ++I+A P Q I + F+ + +E +CK+
Sbjct: 40 QCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAA-PRQCIELYFDEKYSIEPSWECKF 98
Query: 85 DYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEI---- 140
D++EV DG G+FCG+ PP + SSG FL+IKF +D E GFS RY
Sbjct: 99 DHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDP 158
Query: 141 -------FKRGPECSQNYTTPSGVIKSPGFPEK----YPNSLECTYIVFAPKMSEIILEF 189
K P C G+++S ++ +++C + + AP S+I L F
Sbjct: 159 DFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRF 218
Query: 190 ESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQ-KTPGRIRSSSGILSM 245
++++ + C+ + + ++DG V ++C +R+ G++ M
Sbjct: 219 LDYEMQNSNE------CKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRM 269
Score = 80.9 bits (198), Expect = 3e-15
Identities = 53/160 (33%), Positives = 72/160 (45%), Gaps = 20/160 (12%)
Query: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEF-ESFDLEPDSNPPGGMFCRYDRLEIW 214
G+ SP +P KYP EC YI+ A I L F E + +EP C++D +E+
Sbjct: 51 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWE------CKFDHIEVR 104
Query: 215 DGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDF- 273
DG P IGR+CGQ+ P I+SS L + F+ D + GFSA Y+ +D
Sbjct: 105 DGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLG 164
Query: 274 ------KCMEALGMESGEIHSDQI------TASSQYSTNW 301
C +G G + S QI TAS W
Sbjct: 165 ALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKW 204
>gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2
precursor [Homo sapiens]
Length = 532
Score = 102 bits (255), Expect = 8e-22
Identities = 67/237 (28%), Positives = 112/237 (47%), Gaps = 24/237 (10%)
Query: 26 KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKY 84
+CG K G TSP YP Y P +C ++I+A P Q I + F+ + +E +CK+
Sbjct: 39 QCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAA-PRQCIELYFDEKYSIEPSWECKF 97
Query: 85 DYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEI---- 140
D++EV DG G+FCG+ PP + SSG FL+IKF +D E GFS RY
Sbjct: 98 DHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDP 157
Query: 141 -------FKRGPECSQNYTTPSGVIKSPGFPEK----YPNSLECTYIVFAPKMSEIILEF 189
K P C G+++S ++ +++C + + AP S+I L F
Sbjct: 158 DFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRF 217
Query: 190 ESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQ-KTPGRIRSSSGILSM 245
++++ + C+ + + ++DG V ++C +R+ G++ M
Sbjct: 218 LDYEMQNSNE------CKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRM 268
Score = 80.9 bits (198), Expect = 3e-15
Identities = 53/160 (33%), Positives = 72/160 (45%), Gaps = 20/160 (12%)
Query: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEF-ESFDLEPDSNPPGGMFCRYDRLEIW 214
G+ SP +P KYP EC YI+ A I L F E + +EP C++D +E+
Sbjct: 50 GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWE------CKFDHIEVR 103
Query: 215 DGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDF- 273
DG P IGR+CGQ+ P I+SS L + F+ D + GFSA Y+ +D
Sbjct: 104 DGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLG 163
Query: 274 ------KCMEALGMESGEIHSDQI------TASSQYSTNW 301
C +G G + S QI TAS W
Sbjct: 164 ALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKW 203
>gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Homo
sapiens]
Length = 525
Score = 101 bits (251), Expect = 2e-21
Identities = 58/220 (26%), Positives = 111/220 (50%), Gaps = 24/220 (10%)
Query: 26 KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKY 84
+CG ++ + G+ SP YP SY P+++C ++++A P QRI + F+ H+ +E +C++
Sbjct: 44 QCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAA-PRQRIELTFDEHYYIEPSFECRF 102
Query: 85 DYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE----- 139
D++EV DG ++CG +PP + S+G F++IKF SD E G GF +Y
Sbjct: 103 DHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDP 162
Query: 140 -------IFKRGPECSQNYTTPSGVIKSPGFPE----KYPNSLECTYIVFAPKMSEIILE 188
I P+C + G+++S + K +++C + + A ++I L
Sbjct: 163 DFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLR 222
Query: 189 FESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYC 228
F + +E + C+ + + ++DG + ++C
Sbjct: 223 FLDYQMEHSNE------CKRNFVAVYDGSSSIENLKAKFC 256
Score = 73.2 bits (178), Expect = 7e-13
Identities = 43/115 (37%), Positives = 59/115 (51%), Gaps = 7/115 (6%)
Query: 152 TTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEF-ESFDLEPDSNPPGGMFCRYDR 210
T+ G SP +P+ YP + EC YI+ A I L F E + +EP CR+D
Sbjct: 51 TSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFE------CRFDH 104
Query: 211 LEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
LE+ DG P I RYCG K+P IRS+ + + F +D + GF A YS +
Sbjct: 105 LEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFI 159
Score = 38.1 bits (87), Expect = 0.025
Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 54 CEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVV 113
C W I+A P +I + F + +CK ++V V+DG + + + KFC +A ++
Sbjct: 207 CIWTIKAT-PKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVML 265
Query: 114 SSG 116
+G
Sbjct: 266 KTG 268
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 96.3 bits (238), Expect = 8e-20
Identities = 57/157 (36%), Positives = 85/157 (54%), Gaps = 8/157 (5%)
Query: 275 CMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPEN--GWTPG----EDSYREWIQV 328
C LGM G+I + ITASSQ+S + +A+ RL+ E W P D +E++Q+
Sbjct: 30 CRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQI 89
Query: 329 DLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPT 388
DL L F+T VGTQG + ++ YKI+ S +G WI+ + + + GN+NP
Sbjct: 90 DLHTLHFITLVGTQGRHAGGHGIEF-APMYKINYSRDGTRWISWRNRHGKQVLDGNSNPY 148
Query: 389 DVVVAVFPKPLITRFVRIKPAT-WETGISMRFEVYGC 424
D+ + P++ RFVR P T + MR E+YGC
Sbjct: 149 DIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGC 185
Score = 52.4 bits (124), Expect = 1e-06
Identities = 47/159 (29%), Positives = 72/159 (45%), Gaps = 9/159 (5%)
Query: 431 CSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWA----LPPAPHSYINEWLQ 486
C LGM G I D IT+S+Q + + RL + A +P P + E+LQ
Sbjct: 30 CRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDD-LKEFLQ 88
Query: 487 IDLGEEKIVRGIIIQGGKHRENKV-FMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNN 545
IDL + + QG + + F +KI YS +G+ W I ++ + +GN+N
Sbjct: 89 IDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRW--ISWRNRHGKQVLDGNSN 146
Query: 546 -YDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGC 583
YD P + RF+R P + +R+EL GC
Sbjct: 147 PYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGC 185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.137 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,998,165
Number of Sequences: 37866
Number of extensions: 1451229
Number of successful extensions: 3624
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2549
Number of HSP's gapped (non-prelim): 475
length of query: 644
length of database: 18,247,518
effective HSP length: 109
effective length of query: 535
effective length of database: 14,120,124
effective search space: 7554266340
effective search space used: 7554266340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.