Guide to the Human Genome
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Search of human proteins with 66864913

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66864913 neuropilin 1 isoform c [Homo sapiens]
         (609 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66864913 neuropilin 1 isoform c [Homo sapiens]                    1268   0.0  
gi|66912178 neuropilin 1 isoform b [Homo sapiens]                    1250   0.0  
gi|182508169 neuropilin 1 isoform a [Homo sapiens]                   1244   0.0  
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]           644   0.0  
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]           644   0.0  
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]           644   0.0  
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]           644   0.0  
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]           644   0.0  
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]           585   e-167
gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Ho...   169   5e-42
gi|31317224 EGF-like repeats and discoidin I-like domains-contai...   169   7e-42
gi|4503647 coagulation factor VIII isoform a precursor [Homo sap...   160   3e-39
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]      151   1e-36
gi|22547221 tolloid-like 1 [Homo sapiens]                             142   1e-33
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]      141   2e-33
gi|6912724 tolloid-like 2 [Homo sapiens]                              139   6e-33
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...   139   8e-33
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...   139   8e-33
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...   139   8e-33
gi|105990535 coagulation factor V precursor [Homo sapiens]            138   2e-32
gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo sa...   138   2e-32
gi|126091152 cubilin [Homo sapiens]                                   132   9e-31
gi|72384339 CUB domain containing protein 2 [Homo sapiens]            130   3e-30
gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Ho...   115   2e-25
gi|10518506 coagulation factor VIII isoform b precursor [Homo sa...   113   4e-25
gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo sa...   110   4e-24
gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3 pre...   102   8e-22
gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2 pre...   102   8e-22
gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Ho...   101   2e-21
gi|62420886 discoidin domain receptor family, member 2 precursor...    96   7e-20

>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
          Length = 609

 Score = 1268 bits (3280), Expect = 0.0
 Identities = 609/609 (100%), Positives = 609/609 (100%)

Query: 1   MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
           MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
Sbjct: 1   MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60

Query: 61  PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
           PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
Sbjct: 61  PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120

Query: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
           IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP
Sbjct: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180

Query: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
           KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
Sbjct: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240

Query: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
           GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
Sbjct: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300

Query: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
           WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
Sbjct: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360

Query: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
           DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
Sbjct: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420

Query: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
           VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
Sbjct: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480

Query: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
           INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
Sbjct: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540

Query: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVI 600
           EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVI
Sbjct: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVI 600

Query: 601 DSTIQSGIK 609
           DSTIQSGIK
Sbjct: 601 DSTIQSGIK 609


>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
          Length = 644

 Score = 1250 bits (3234), Expect = 0.0
 Identities = 609/644 (94%), Positives = 609/644 (94%), Gaps = 35/644 (5%)

Query: 1   MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
           MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
Sbjct: 1   MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60

Query: 61  PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
           PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
Sbjct: 61  PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120

Query: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
           IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP
Sbjct: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180

Query: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
           KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
Sbjct: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240

Query: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
           GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
Sbjct: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300

Query: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
           WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
Sbjct: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360

Query: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
           DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
Sbjct: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420

Query: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
           VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
Sbjct: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480

Query: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
           INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
Sbjct: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540

Query: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVE-------------- 586
           EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVE              
Sbjct: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600

Query: 587 ---------------------GGTTVLATEKPTVIDSTIQSGIK 609
                                GGTTVLATEKPTVIDSTIQSGIK
Sbjct: 601 DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSGIK 644


>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
          Length = 923

 Score = 1244 bits (3219), Expect = 0.0
 Identities = 606/641 (94%), Positives = 606/641 (94%), Gaps = 35/641 (5%)

Query: 1   MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60
           MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
Sbjct: 1   MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA 60

Query: 61  PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120
           PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
Sbjct: 61  PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF 120

Query: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180
           IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP
Sbjct: 121 IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAP 180

Query: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240
           KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
Sbjct: 181 KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS 240

Query: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300
           GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
Sbjct: 241 GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN 300

Query: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360
           WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
Sbjct: 301 WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI 360

Query: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420
           DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
Sbjct: 361 DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE 420

Query: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480
           VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
Sbjct: 421 VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY 480

Query: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540
           INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
Sbjct: 481 INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF 540

Query: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVE-------------- 586
           EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVE              
Sbjct: 541 EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600

Query: 587 ---------------------GGTTVLATEKPTVIDSTIQS 606
                                GGTTVLATEKPTVIDSTIQS
Sbjct: 601 DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQS 641


>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
          Length = 909

 Score =  644 bits (1660), Expect = 0.0
 Identities = 301/582 (51%), Positives = 414/582 (71%), Gaps = 10/582 (1%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147

Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207

Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267

Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327

Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387

Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447

Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506

Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
           +        E + F+RKFK+ YS NG DW+ I D   ++ K FEGN +YDTP++R F  +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566

Query: 558 STRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTV 599
             +++R+YPER +  G+G+R+E+LGC+       + T  PTV
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTV 608


>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
          Length = 901

 Score =  644 bits (1660), Expect = 0.0
 Identities = 301/582 (51%), Positives = 414/582 (71%), Gaps = 10/582 (1%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147

Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207

Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267

Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327

Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387

Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447

Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506

Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
           +        E + F+RKFK+ YS NG DW+ I D   ++ K FEGN +YDTP++R F  +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566

Query: 558 STRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTV 599
             +++R+YPER +  G+G+R+E+LGC+       + T  PTV
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTV 608


>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
          Length = 931

 Score =  644 bits (1660), Expect = 0.0
 Identities = 301/582 (51%), Positives = 414/582 (71%), Gaps = 10/582 (1%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147

Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207

Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267

Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327

Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387

Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447

Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506

Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
           +        E + F+RKFK+ YS NG DW+ I D   ++ K FEGN +YDTP++R F  +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566

Query: 558 STRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTV 599
             +++R+YPER +  G+G+R+E+LGC+       + T  PTV
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTV 608


>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
          Length = 906

 Score =  644 bits (1660), Expect = 0.0
 Identities = 301/582 (51%), Positives = 414/582 (71%), Gaps = 10/582 (1%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147

Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207

Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267

Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327

Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387

Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447

Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506

Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
           +        E + F+RKFK+ YS NG DW+ I D   ++ K FEGN +YDTP++R F  +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566

Query: 558 STRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTV 599
             +++R+YPER +  G+G+R+E+LGC+       + T  PTV
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTV 608


>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
          Length = 926

 Score =  644 bits (1660), Expect = 0.0
 Identities = 301/582 (51%), Positives = 414/582 (71%), Gaps = 10/582 (1%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147

Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207

Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267

Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327

Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387

Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447

Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506

Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557
           +        E + F+RKFK+ YS NG DW+ I D   ++ K FEGN +YDTP++R F  +
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566

Query: 558 STRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTV 599
             +++R+YPER +  G+G+R+E+LGC+       + T  PTV
Sbjct: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTV 608


>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
          Length = 555

 Score =  585 bits (1508), Expect = e-167
 Identities = 275/521 (52%), Positives = 373/521 (71%), Gaps = 10/521 (1%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147

Query: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207

Query: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267

Query: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327

Query: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387

Query: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447

Query: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506

Query: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAK 538
           +        E + F+RKFK+ YS NG DW+ I D   ++ K
Sbjct: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPK 547



 Score =  133 bits (334), Expect = 5e-31
 Identities = 126/449 (28%), Positives = 198/449 (44%), Gaps = 74/449 (16%)

Query: 155 SGVIKSPGFPEKYPNSLECTYIVFAPKMSE-IILEFES-FDLEPDSNPPGGMFCRYDRLE 212
           +G I SPG+P+ YP+   C +IV+AP+ ++ I+L F   F++E          C+YD +E
Sbjct: 37  AGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-------CKYDFIE 89

Query: 213 IWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSED 272
           I DG  +    +G++CG   P  I SS  +L + F +D A    GFS  Y + ++  SED
Sbjct: 90  IRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG-SED 148

Query: 273 FKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGL 332
             C +     +G I S       +Y  N     + L  P+                    
Sbjct: 149 --CSKNFTSPNGTIESPGFP--EKYPHNLDCTFTILAKPK-------------------- 184

Query: 333 LRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGE-----DWITIKEGNKPV-----LFQ 382
                          E   ++ +   + D    GE     DW+ I +G   V      + 
Sbjct: 185 --------------MEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYC 230

Query: 383 GNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE-VYGCKITDYPCSGMLGMVSGL 441
           G   P+++  +     +++       A  + G S R+  V+   + ++ C+  LGM SG 
Sbjct: 231 GTKTPSELRSST---GILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGR 287

Query: 442 ISDSQIT-SSNQGDRNWMPENIRLVTSRSGWALPPAPHSYIN-EWLQIDLGEEKIVRGII 499
           I++ QI+ SS   D  W P+  RL    +GW     P+   N E+LQ+DL    ++  I 
Sbjct: 288 IANEQISASSTYSDGRWTPQQSRLHGDDNGWT----PNLDSNKEYLQVDLRFLTMLTAIA 343

Query: 500 IQGGKHRE--NKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPA- 556
            QG   RE  N  +++ +K+  S NG DW +       K   F+ NN+     L    A 
Sbjct: 344 TQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANNDATEVVLNKLHAP 401

Query: 557 LSTRFIRIYPERATHGGLGLRMELLGCEV 585
           L TRF+RI P+   H G+ LR+EL GC V
Sbjct: 402 LLTRFVRIRPQ-TWHSGIALRLELFGCRV 429


>gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Homo
           sapiens]
          Length = 387

 Score =  169 bits (429), Expect = 5e-42
 Identities = 123/355 (34%), Positives = 183/355 (51%), Gaps = 33/355 (9%)

Query: 246 VFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYST-----N 300
           VF + +    +G++ N+         + KC+E LG+E+G I + QI ASS   T     +
Sbjct: 49  VFPSYTCTCLKGYAGNHC--------ETKCVEPLGLENGNIANSQIAASSVRVTFLGLQH 100

Query: 301 WSAERSRLNYPE--NGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTY 358
           W  E +RLN     N WTP  +    WIQV+L    +VT V TQGA    + +  Y+K +
Sbjct: 101 WVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHE--YLKAF 158

Query: 359 KIDVSSNGEDWITIKEGNKPVL-FQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISM 417
           K+  S NG ++  I + NK    F GN N   V V +F  P+  ++VR+ P +  T  ++
Sbjct: 159 KVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTL 218

Query: 418 RFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDR------NWMPENIRLVTSRSGW 471
           RFE+ GC++    C+  LG+ +  I D QIT+S+          +W P   RL   + G 
Sbjct: 219 RFELLGCELNG--CANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARL--DKQGN 274

Query: 472 ALPPAPHSYINE-WLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIM 530
                  SY N+ WLQ+DLG  K V GII QG ++  +  F+  +K+ YSN+ ++W    
Sbjct: 275 FNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQ 334

Query: 531 DDSKRKAKSFEGN--NNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGC 583
           D     +K F GN  N+     L   P L+ R++RI P  A H  + LR+ELLGC
Sbjct: 335 DPRTGSSKIFPGNWDNHSHKKNLFETPILA-RYVRILPV-AWHNRIALRLELLGC 387



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 59/181 (32%), Positives = 95/181 (52%), Gaps = 11/181 (6%)

Query: 431 CSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSRSGWALPPAPHSYI-NEW 484
           C   LG+ +G I++SQI +S+      G ++W+PE  RL  +R+G      P S   N W
Sbjct: 70  CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARL--NRAGMVNAWTPSSNDDNPW 127

Query: 485 LQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNN 544
           +Q++L     V G++ QG     +  +++ FK+ YS NG ++  I D +K K K F GN 
Sbjct: 128 IQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNK-KHKEFVGNW 186

Query: 545 NYDTPELRTFPA-LSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVIDST 603
           N +   +  F   +  +++R+YP  + H    LR ELLGCE+ G    L  +  ++ D  
Sbjct: 187 NKNAVHVNLFETPVEAQYVRLYPT-SCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQ 245

Query: 604 I 604
           I
Sbjct: 246 I 246


>gi|31317224 EGF-like repeats and discoidin I-like
           domains-containing protein 3 [Homo sapiens]
          Length = 480

 Score =  169 bits (428), Expect = 7e-42
 Identities = 118/332 (35%), Positives = 168/332 (50%), Gaps = 26/332 (7%)

Query: 273 FKCMEALGMESGEIHSDQITASSQYST-----NWSAERSRLNYPE--NGWTPGEDSYREW 325
           +KC   LG+E G I + QITASS +        W    +RLN     N WT  E+    W
Sbjct: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215

Query: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWIT--IKEGNKPVLFQG 383
           IQ++L     VT V TQGA  K      Y+K+YKI  S++G+ W    +K  N+ ++F+G
Sbjct: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273

Query: 384 NTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLIS 443
           N +        F  P+  ++VR+ P       ++R E+ GC+++   CS  LGM SG I 
Sbjct: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331

Query: 444 DSQITSS------NQGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
           D QIT+S      N     W P   RL      + W    + H+  ++WLQ+DL     V
Sbjct: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWT---SGHNDQSQWLQVDLLVPTKV 388

Query: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
            GII QG K   +  F+  +K+ YSN+G  W +  D+ +RK K F+GN + DT       
Sbjct: 389 TGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVID 448

Query: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEVE 586
           P +  R IRI P  + +G + LR ELLGC  E
Sbjct: 449 PPIYARHIRILP-WSWYGRITLRSELLGCTEE 479



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 61/184 (33%), Positives = 93/184 (50%), Gaps = 12/184 (6%)

Query: 429 YPCSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSR--SGWALPPAPHSYI 481
           Y CSG LG+  G+IS+ QIT+S+      G + W P   RL      + W    A  +  
Sbjct: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWT---AAENDR 212

Query: 482 NEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFE 541
             W+QI+L  +  V G+I QG K   +  +++ +KI YSN+G  W M       +   F 
Sbjct: 213 WPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFR 272

Query: 542 GNNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVI 600
           GN + +TP   +F P +  +++R+YP+        LRMELLGCE+ G +  L  +   + 
Sbjct: 273 GNIDNNTPYANSFTPPIKAQYVRLYPQ-VCRRHCTLRMELLGCELSGCSEPLGMKSGHIQ 331

Query: 601 DSTI 604
           D  I
Sbjct: 332 DYQI 335


>gi|4503647 coagulation factor VIII isoform a precursor [Homo sapiens]
          Length = 2351

 Score =  160 bits (405), Expect = 3e-39
 Identities = 109/321 (33%), Positives = 164/321 (51%), Gaps = 19/321 (5%)

Query: 274  KCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPE--NGWTPGEDSYREWIQVDLG 331
            KC   LGM SG I   QITAS QY   W+ + +RL+Y    N W+  E     WI+VDL 
Sbjct: 2039 KCQTPLGMASGHIRDFQITASGQYG-QWAPKLARLHYSGSINAWSTKEPF--SWIKVDLL 2095

Query: 332  LLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVL--FQGNTNPTD 389
                +  + TQGA  K +    Y+  + I  S +G+ W T +  +   L  F GN + + 
Sbjct: 2096 APMIIHGIKTQGARQKFSS--LYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSG 2153

Query: 390  VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITS 449
            +   +F  P+I R++R+ P  +    ++R E+ GC +    CS  LGM S  ISD+QIT+
Sbjct: 2154 IKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDAQITA 2211

Query: 450  SNQGDR---NWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHR 506
            S+        W P   RL       A  P  ++   EWLQ+D  +   V G+  QG K  
Sbjct: 2212 SSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNP-KEWLQVDFQKTMKVTGVTTQGVKSL 2270

Query: 507  ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIY 565
               +++++F I  S +G  W +   +   K K F+GN +  TP + +  P L TR++RI+
Sbjct: 2271 LTSMYVKEFLISSSQDGHQWTLFFQNG--KVKVFQGNQDSFTPVVNSLDPPLLTRYLRIH 2328

Query: 566  PERATHGGLGLRMELLGCEVE 586
            P+   H  + LRME+LGCE +
Sbjct: 2329 PQSWVH-QIALRMEVLGCEAQ 2348



 Score =  103 bits (257), Expect = 5e-22
 Identities = 62/159 (38%), Positives = 83/159 (52%), Gaps = 7/159 (4%)

Query: 275  CMEALGMESGEIHSDQITASSQYST---NWSAERSRLNYP--ENGWTPGEDSYREWIQVD 329
            C   LGMES  I   QITASS ++     WS  ++RL+     N W P  ++ +EW+QVD
Sbjct: 2193 CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 2252

Query: 330  LGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTD 389
                  VT V TQG  S  T    YVK + I  S +G  W    +  K  +FQGN +   
Sbjct: 2253 FQKTMKVTGVTTQGVKSLLTSM--YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 2310

Query: 390  VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITD 428
             VV     PL+TR++RI P +W   I++R EV GC+  D
Sbjct: 2311 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 2349



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 65/196 (33%), Positives = 97/196 (49%), Gaps = 19/196 (9%)

Query: 414  GISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRS--GW 471
            G+S  F VY  K     C   LGM SG I D QIT+S Q  + W P+  RL  S S   W
Sbjct: 2028 GMSTLFLVYSNK-----CQTPLGMASGHIRDFQITASGQYGQ-WAPKLARLHYSGSINAW 2081

Query: 472  ALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMD 531
            +    P S    W+++DL    I+ GI  QG + + + +++ +F I YS +G  W+    
Sbjct: 2082 STKE-PFS----WIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRG 2136

Query: 532  DSKRKAKSFEGNNNYDTPELRTF-PALSTRFIRIYPERATHGGL--GLRMELLGCEVEGG 588
            +S      F GN +    +   F P +  R+IR++P   TH  +   LRMEL+GC++   
Sbjct: 2137 NSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHP---THYSIRSTLRMELMGCDLNSC 2193

Query: 589  TTVLATEKPTVIDSTI 604
            +  L  E   + D+ I
Sbjct: 2194 SMPLGMESKAISDAQI 2209


>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
          Length = 449

 Score =  151 bits (382), Expect = 1e-36
 Identities = 88/253 (34%), Positives = 135/253 (53%), Gaps = 16/253 (6%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
           CG  +K ES GY+ S G+P+ Y P+++C W I  P+  Q + ++F   FDLE    C+YD
Sbjct: 37  CGGDVKGES-GYVASEGFPNLYPPNKECIWTITVPEG-QTVSLSFRV-FDLELHPACRYD 93

Query: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE-IFKRG 144
            +EVF G   +G   G+FCG   P P+V+ G  + ++  +D  T G GF + Y      G
Sbjct: 94  ALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSG 153

Query: 145 PE---CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
            E   C        G + +P +PE  YP  + C++ + AP    I L FE FDLEPD+  
Sbjct: 154 TEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDT-- 211

Query: 201 PGGMFCRYDRLEIWDG-FPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
               +CRYD + +++G   D    +G++CG   PG I S    L + F +D ++  +GFS
Sbjct: 212 ----YCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFS 267

Query: 260 ANYSVLQSSVSED 272
           A+Y  L    +++
Sbjct: 268 ASYKTLPRGTAKE 280



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 49/172 (28%), Positives = 74/172 (43%), Gaps = 25/172 (14%)

Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
           C  +    SG + S GFP  YP + EC + +  P+   + L F  FDLE   +P     C
Sbjct: 37  CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLE--LHPA----C 90

Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
           RYD LE++ G    G  +GR+CG   P  + +    +++   TD      GF   YS   
Sbjct: 91  RYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRA 150

Query: 267 SSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPG 318
           +S +E   C        G +   Q T ++             N+PE+ + PG
Sbjct: 151 TSGTEHQFC-------GGRLEKAQGTLTTP------------NWPESDYPPG 183


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score =  142 bits (357), Expect = 1e-33
 Identities = 86/265 (32%), Positives = 131/265 (49%), Gaps = 19/265 (7%)

Query: 22  FRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD 81
           +R   CG+T++ ES G L+SPG+P+ Y     C W +    P ++I++NF      +   
Sbjct: 344 YRCPACGETLQ-ESNGNLSSPGFPNGYPSYTHCIWRVSVT-PGEKIVLNFTTMDLYKSSL 401

Query: 82  CKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIF 141
           C YDY+EV DG        G+FCG   P  + S+   ++I+F S     G GF+  YE  
Sbjct: 402 CWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461

Query: 142 KRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPP 201
                C        G I+SP +P+ Y    EC + +   +   + L F+SF++E   N  
Sbjct: 462 -----CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDN-- 514

Query: 202 GGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN 261
               C YD LE+ DG  +  P IGR+CG   P  IRS+S  L M F +D  + K GF+AN
Sbjct: 515 ----CAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAAN 570

Query: 262 YSVLQSSVSE------DFKCMEALG 280
           +   +   ++      + +C+  LG
Sbjct: 571 FFKEEDECAKPDRGGCEQRCLNTLG 595



 Score =  139 bits (350), Expect = 8e-33
 Identities = 89/300 (29%), Positives = 141/300 (47%), Gaps = 57/300 (19%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
           CG  I+ ++ G + SP YP  Y P ++C W I   + Y  + + F   F++E  D C YD
Sbjct: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSESYH-VGLTFQS-FEIERHDNCAYD 518

Query: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
           Y+EV DG +EN    G+FCG   P  + S+   L++KFVSD   + AGF+  +  FK   
Sbjct: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF--FKEED 576

Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
           EC++                                          T  +G I +PG+P+
Sbjct: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK 636

Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
           +YP +  C + V AP    I ++FE F+LE      G   C+YD +EIW G        G
Sbjct: 637 EYPPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHG 690

Query: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSED-----FKCMEALG 280
           ++CG + P  I S    + + F +D+ ++K+GF A++   +   S+D      +C+  +G
Sbjct: 691 KFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMG 750



 Score =  138 bits (348), Expect = 1e-32
 Identities = 82/266 (30%), Positives = 124/266 (46%), Gaps = 47/266 (17%)

Query: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
           G +T+PG+P  Y P++ C W + AP  Y RI + F   F+LE  + CKYDYVE++ G + 
Sbjct: 627 GTITTPGWPKEYPPNKNCVWQVVAPTQY-RISVKFE-FFELEGNEVCKYDYVEIWSGLSS 684

Query: 96  NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK------------- 142
                GKFCG   P  + S    + I+F SD      GF   +   K             
Sbjct: 685 ESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHE 744

Query: 143 -------------------------RGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIV 177
                                    +  EC Q   +PSG+I SP +P+KYP+  ECT+ +
Sbjct: 745 CVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEI 804

Query: 178 FAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIR 237
            A     I L F  F++E          C YD LE++DG  +  P +GR CG K P  + 
Sbjct: 805 SATPGHRIKLAFSEFEIEQHQE------CAYDHLEVFDGETEKSPILGRLCGNKIPDPLV 858

Query: 238 SSSGILSMVFYTDSAIAKEGFSANYS 263
           ++   + + F +D+++ ++GF A +S
Sbjct: 859 ATGNKMFVRFVSDASVQRKGFQATHS 884



 Score =  133 bits (334), Expect = 5e-31
 Identities = 77/241 (31%), Positives = 127/241 (52%), Gaps = 19/241 (7%)

Query: 32   KIESP-GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLED-RDCKYDYVEV 89
            KI SP G +TSP +P  Y   ++C W I A  P  RI + F+  F++E  ++C YD++EV
Sbjct: 777  KIHSPSGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAFS-EFEIEQHQECAYDHLEV 834

Query: 90   FDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECS- 148
            FDGE E     G+ CG   P P+V++G  +F++FVSD      GF   +       EC  
Sbjct: 835  FDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH-----STECGG 889

Query: 149  --QNYTTPSGVIKSPGFPE-KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
              +  + P  +     F +  YP  ++C +++ + + S + L F++F++E +++      
Sbjct: 890  RLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEAD------ 943

Query: 206  CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
            C YD +E++DG       +GR+CG   P  I S    + + F+TD  I K+GF   Y  +
Sbjct: 944  CGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003

Query: 266  Q 266
            +
Sbjct: 1004 R 1004


>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
          Length = 415

 Score =  141 bits (356), Expect = 2e-33
 Identities = 87/243 (35%), Positives = 135/243 (55%), Gaps = 17/243 (6%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDCKYD 85
           CG  +  ES G++ S G+P  Y P+ KC W I  P+  + +++NF    DLE D  C+YD
Sbjct: 33  CGGILTGES-GFIGSEGFPGVYPPNSKCTWKITVPEG-KVVVLNFR-FIDLESDNLCRYD 89

Query: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY---EIFK 142
           +V+V++G + NG   G+FCG   P  +VSSG  + ++ +SD  T G GF   +   E  +
Sbjct: 90  FVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148

Query: 143 RGPE-CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
           RG + C      PSG  K+P +P++ YP  + C + + APK   I L+FE FD+E D+  
Sbjct: 149 RGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDN-- 206

Query: 201 PGGMFCRYDRLEIWDGFP-DVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
               +CRYD + +++G   +    IG+YCG   P  I S    L + F +D ++  +GF 
Sbjct: 207 ----YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262

Query: 260 ANY 262
            +Y
Sbjct: 263 GHY 265



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 7/138 (5%)

Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
           C    T  SG I S GFP  YP + +CT+ +  P+   ++L F   DLE D+       C
Sbjct: 33  CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDN------LC 86

Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
           RYD +++++G  + G  IGR+CG   PG + SS   + +   +D+  A  GF A +S  +
Sbjct: 87  RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145

Query: 267 SSVSEDFKCMEALGMESG 284
            +   D  C   L   SG
Sbjct: 146 PNERGDQYCGGLLDRPSG 163


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score =  139 bits (351), Expect = 6e-33
 Identities = 80/236 (33%), Positives = 124/236 (52%), Gaps = 13/236 (5%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG+T++ ++ G  ++PG+P+ Y     C W I    P ++I++NF      + R C YDY
Sbjct: 351 CGETLQ-DTTGNFSAPGFPNGYPSYSHCVWRISVT-PGEKIVLNFTSMDLFKSRLCWYDY 408

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           VEV DG        G+FCG   P P+VS+   L+++F S     G GF   YE       
Sbjct: 409 VEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYE-----AT 463

Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
           C  +    +G I+SP +P+ Y  S EC + +   +   + L F++F++E   +      C
Sbjct: 464 CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDS------C 517

Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
            YD LE+ DG  +    IG +CG + P  ++SSS  L M F +D +I K GF+AN+
Sbjct: 518 AYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF 573



 Score =  135 bits (339), Expect = 1e-31
 Identities = 92/278 (33%), Positives = 131/278 (47%), Gaps = 54/278 (19%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
           CG  +  ++ G + SP YP  Y PS++C W I   + +  + + F   F++E  D C YD
Sbjct: 464 CGGDMNKDA-GQIQSPNYPDDYRPSKECVWRITVSEGFH-VGLTFQA-FEIERHDSCAYD 520

Query: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
           Y+EV DG  E     G FCG   P  V SS   L++KFVSD   + AGF+  +  FK   
Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF--FKEVD 578

Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
           ECS                                           T  +G I SPG+P+
Sbjct: 579 ECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPK 638

Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGF-PDVGPHI 224
           +YP +  C + V AP    I L+FE F+LE      G   C+YD +E+  G  PD   H 
Sbjct: 639 EYPTNKNCVWQVVAPAQYRISLQFEVFELE------GNDVCKYDFVEVRSGLSPDAKLH- 691

Query: 225 GRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
           GR+CG +TP  I S S  + + F +D+ ++K GF A++
Sbjct: 692 GRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHF 729



 Score =  131 bits (329), Expect = 2e-30
 Identities = 89/329 (27%), Positives = 142/329 (43%), Gaps = 71/329 (21%)

Query: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
           G +TSPG+P  Y  ++ C W + AP  Y RI + F   F+LE  D CKYD+VEV  G + 
Sbjct: 629 GTITSPGWPKEYPTNKNCVWQVVAPAQY-RISLQFEV-FELEGNDVCKYDFVEVRSGLSP 686

Query: 96  NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIR------------------ 137
           +    G+FCG   P  + S    + ++F SD      GF                     
Sbjct: 687 DAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHE 746

Query: 138 ---------------YEIFKRGPECSQ-----NYTTPSGVIKSPGFPEKYPNSLECTYIV 177
                          Y + + G +C +       ++  G + SP +P+KYP+  ECT+ +
Sbjct: 747 CVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNI 806

Query: 178 FAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIR 237
            +     + L F  F++E          C YD LE++DG   + P +GR+CG K P    
Sbjct: 807 SSTAGHRVKLTFNEFEIEQHQE------CAYDHLEMYDGPDSLAPILGRFCGSKKPDPTV 860

Query: 238 SSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQY 297
           +S   + + FY+D+++ ++GF A +S             E  G    E+ + ++ + +Q+
Sbjct: 861 ASGSSMFLRFYSDASVQRKGFQAVHST------------ECGGRLKAEVQTKELYSHAQF 908

Query: 298 STNWSAERSRLNYPENG---WT-PGEDSY 322
             N        NYP      W    ED Y
Sbjct: 909 GDN--------NYPSEARCDWVIVAEDGY 929



 Score =  120 bits (300), Expect = 5e-27
 Identities = 72/240 (30%), Positives = 116/240 (48%), Gaps = 11/240 (4%)

Query: 26   KCGDTIKIES-PGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLED-RDCK 83
            + G   KI S  G L SP +P  Y    +C W I +   + R+ + FN  F++E  ++C 
Sbjct: 773  EAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGH-RVKLTFN-EFEIEQHQECA 830

Query: 84   YDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
            YD++E++DG +      G+FCG   P P V+SG  +F++F SD      GF   +   + 
Sbjct: 831  YDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHST-EC 889

Query: 144  GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
            G        T      +      YP+   C +++ A     + L F +F++E +++    
Sbjct: 890  GGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEAD---- 945

Query: 204  MFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYS 263
              C YD +E +DG+    P +GR+CG      I S+   L + F TD  I K+GF A Y+
Sbjct: 946  --CGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYT 1003



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 42/144 (29%), Positives = 65/144 (45%), Gaps = 15/144 (10%)

Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
           P C +     +G   +PGFP  YP+   C + +      +I+L F S DL          
Sbjct: 349 PACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFK------SR 402

Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
            C YD +E+ DG+    P +GR+CG K P  + S+   L + F + S I  +GF A Y  
Sbjct: 403 LCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAY-- 460

Query: 265 LQSSVSEDFKCMEALGMESGEIHS 288
                  +  C   +  ++G+I S
Sbjct: 461 -------EATCGGDMNKDAGQIQS 477


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score =  139 bits (350), Expect = 8e-33
 Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG+T++ +S G  +SP YP+ Y     C W I    P ++I++NF        R C YDY
Sbjct: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           VEV DG       RG+FCG   P P+VS+   L+++F S     G GF   YE       
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434

Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
           C  +     G I+SP +P+ Y  S  C + +   +   + L F+SF++E   +      C
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488

Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
            YD LE+ DG  +    IGRYCG + P  I+S+S  L + F +D +I K GF+ N+
Sbjct: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544



 Score =  129 bits (323), Expect = 1e-29
 Identities = 82/277 (29%), Positives = 132/277 (47%), Gaps = 52/277 (18%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
           CG  +K +  G++ SP YP  Y PS+ C W IQ  + +  + + F   F++E  D C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491

Query: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
           Y+EV DG +E+    G++CG   P  + S+   L++KFVSD   + AGF++ +  FK   
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549

Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
           ECS+                                          T  +G I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609

Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
           +YP +  C + + AP    I L+F+ F+ E      G   C+YD +E+  G        G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663

Query: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
           ++CG + P  I S    + + F +D+ ++K+GF A++
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 41/108 (37%), Positives = 56/108 (51%), Gaps = 3/108 (2%)

Query: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
           G +TSPG+P  Y P++ C W + AP  Y RI + F+  F+ E  D CKYD+VEV  G   
Sbjct: 600 GSITSPGWPKEYPPNKNCIWQLVAPTQY-RISLQFD-FFETEGNDVCKYDFVEVRSGLTA 657

Query: 96  NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
           +    GKFCG   P  + S    + ++F SD      GF   +   KR
Sbjct: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKR 705



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)

Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
           P C +     +G   SP +P  Y   + C + +      +IIL F S DL          
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373

Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
            C YD +E+ DGF    P  GR+CG K P  I S+   L + F + S    +GF A Y +
Sbjct: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433

Query: 264 VLQSSVSEDF 273
           +    V +D+
Sbjct: 434 ICGGDVKKDY 443


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score =  139 bits (350), Expect = 8e-33
 Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG+T++ +S G  +SP YP+ Y     C W I    P ++I++NF        R C YDY
Sbjct: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           VEV DG       RG+FCG   P P+VS+   L+++F S     G GF   YE       
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434

Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
           C  +     G I+SP +P+ Y  S  C + +   +   + L F+SF++E   +      C
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488

Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
            YD LE+ DG  +    IGRYCG + P  I+S+S  L + F +D +I K GF+ N+
Sbjct: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544



 Score =  130 bits (326), Expect = 5e-30
 Identities = 85/284 (29%), Positives = 137/284 (48%), Gaps = 53/284 (18%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
           CG  +K +  G++ SP YP  Y PS+ C W IQ  + +  + + F   F++E  D C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491

Query: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
           Y+EV DG +E+    G++CG   P  + S+   L++KFVSD   + AGF++ +  FK   
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549

Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
           ECS+                                          T  +G I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609

Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
           +YP +  C + + AP    I L+F+ F+ E      G   C+YD +E+  G        G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663

Query: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN-YSVLQSS 268
           ++CG + P  I S    + + F +D+ ++K+GF A+ +SVL+ +
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)

Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
           P C +     +G   SP +P  Y   + C + +      +IIL F S DL          
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373

Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
            C YD +E+ DGF    P  GR+CG K P  I S+   L + F + S    +GF A Y +
Sbjct: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433

Query: 264 VLQSSVSEDF 273
           +    V +D+
Sbjct: 434 ICGGDVKKDY 443


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score =  139 bits (350), Expect = 8e-33
 Identities = 83/236 (35%), Positives = 121/236 (51%), Gaps = 13/236 (5%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
           CG+T++ +S G  +SP YP+ Y     C W I    P ++I++NF        R C YDY
Sbjct: 322 CGETLQ-DSTGNFSSPEYPNGYSAHMHCVWRISVT-PGEKIILNFTSLDLYRSRLCWYDY 379

Query: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
           VEV DG       RG+FCG   P P+VS+   L+++F S     G GF   YE       
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAI----- 434

Query: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
           C  +     G I+SP +P+ Y  S  C + +   +   + L F+SF++E   +      C
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS------C 488

Query: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
            YD LE+ DG  +    IGRYCG + P  I+S+S  L + F +D +I K GF+ N+
Sbjct: 489 AYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544



 Score =  132 bits (332), Expect = 9e-31
 Identities = 82/268 (30%), Positives = 126/268 (47%), Gaps = 51/268 (19%)

Query: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95
           G +TSPG+P  Y P++ C W + AP  Y RI + F+  F+ E  D CKYD+VEV  G   
Sbjct: 600 GSITSPGWPKEYPPNKNCIWQLVAPTQY-RISLQFD-FFETEGNDVCKYDFVEVRSGLTA 657

Query: 96  NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQN----- 150
           +    GKFCG   P  + S    + ++F SD      GF   +  F    ECS++     
Sbjct: 658 DSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF--FSDKDECSKDNGGCQ 715

Query: 151 -----------------------------------YTTPSGVIKSPGFPEKYPNSLECTY 175
                                               T+ SG I SP +P+KYP+  ECT+
Sbjct: 716 QDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTW 775

Query: 176 IVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGR 235
            + +     + L F   D+E  S P     C YD LE++DG     P +GR+CG K P  
Sbjct: 776 AISSTPGHRVKLTFMEMDIE--SQPE----CAYDHLEVFDGRDAKAPVLGRFCGSKKPEP 829

Query: 236 IRSSSGILSMVFYTDSAIAKEGFSANYS 263
           + ++   + + FY+D+++ ++GF A+++
Sbjct: 830 VLATGSRMFLRFYSDNSVQRKGFQASHA 857



 Score =  130 bits (327), Expect = 4e-30
 Identities = 67/228 (29%), Positives = 119/228 (52%), Gaps = 10/228 (4%)

Query: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKYDYVEVFDGENE 95
           G +TSP +P  Y   ++C W I +  P  R+ + F    D+E + +C YD++EVFDG + 
Sbjct: 756 GTITSPNWPDKYPSKKECTWAISST-PGHRVKLTFM-EMDIESQPECAYDHLEVFDGRDA 813

Query: 96  NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPS 155
                G+FCG   P PV+++G  +F++F SD      GF   +   + G +   +  T  
Sbjct: 814 KAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHAT-ECGGQVRADVKTKD 872

Query: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWD 215
               +      YP  ++C +++ A +   + L F++F++E +++      C YD +E++D
Sbjct: 873 LYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETD------CGYDYMELFD 926

Query: 216 GFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYS 263
           G+    P +GRYCG   P  + S+   + + F++D  I K+GF   Y+
Sbjct: 927 GYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYT 974



 Score =  130 bits (326), Expect = 5e-30
 Identities = 84/287 (29%), Positives = 136/287 (47%), Gaps = 52/287 (18%)

Query: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
           CG  +K +  G++ SP YP  Y PS+ C W IQ  + +  + + F   F++E  D C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFH-VGLTFQS-FEIERHDSCAYD 491

Query: 86  YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
           Y+EV DG +E+    G++CG   P  + S+   L++KFVSD   + AGF++ +  FK   
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549

Query: 146 ECSQN----------------------------------------YTTPSGVIKSPGFPE 165
           ECS+                                          T  +G I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609

Query: 166 KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG 225
           +YP +  C + + AP    I L+F+ F+ E      G   C+YD +E+  G        G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663

Query: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSED 272
           ++CG + P  I S    + + F +D+ ++K+GF A++   +   S+D
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKD 710



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 40/130 (30%), Positives = 58/130 (44%), Gaps = 7/130 (5%)

Query: 145 PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
           P C +     +G   SP +P  Y   + C + +      +IIL F S DL          
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSR------ 373

Query: 205 FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY-S 263
            C YD +E+ DGF    P  GR+CG K P  I S+   L + F + S    +GF A Y +
Sbjct: 374 LCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA 433

Query: 264 VLQSSVSEDF 273
           +    V +D+
Sbjct: 434 ICGGDVKKDY 443


>gi|105990535 coagulation factor V precursor [Homo sapiens]
          Length = 2224

 Score =  138 bits (347), Expect = 2e-32
 Identities = 105/331 (31%), Positives = 161/331 (48%), Gaps = 28/331 (8%)

Query: 272  DFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNY--PENGWT----PGEDSYREW 325
            D  C   +G+ +G I   QI AS ++   W    +RLN     N W+      E + + W
Sbjct: 1904 DRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPW 1962

Query: 326  IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKP---VLFQ 382
            IQVD+     +T + TQGA  K   K  Y   + +  SSN  +W   K GN     + F 
Sbjct: 1963 IQVDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFK-GNSTRNVMYFN 2019

Query: 383  GNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLI 442
            GN++ + +    F  P++ R++RI P       ++R E+ GC++    CS  LGM +G I
Sbjct: 2020 GNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKI 2077

Query: 443  SDSQITSSN-----QGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
             + QIT+S+      GD  W P   RL      + W    A  +   +WL+IDL + K +
Sbjct: 2078 ENKQITASSFKKSWWGDY-WEPFRARLNAQGRVNAWQ---AKANNNKQWLEIDLLKIKKI 2133

Query: 496  RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
              II QG K   ++++++ + I YS  G +WK     S    K FEGN N        F 
Sbjct: 2134 TAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFN 2193

Query: 555  PALSTRFIRIYPERATHGGLGLRMELLGCEV 585
            P + +RFIR+ P +  +  + LR+EL GC++
Sbjct: 2194 PPIISRFIRVIP-KTWNQSIALRLELFGCDI 2223



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 62/183 (33%), Positives = 97/183 (53%), Gaps = 6/183 (3%)

Query: 426  ITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVT--SRSGWALPPAPHSYINE 483
            I D  C   +G+ +G+ISDSQI +S +    W P   RL    S + W++      + ++
Sbjct: 1902 IMDRDCRMPMGLSTGIISDSQIKAS-EFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASK 1960

Query: 484  -WLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEG 542
             W+Q+D+ +E I+ GI  QG KH     +  +F + YS+N  +W++   +S R    F G
Sbjct: 1961 PWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNG 2020

Query: 543  NNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVID 601
            N++  T +   F P +  R+IRI P RA +    LR+EL GCEV G +T L  E   + +
Sbjct: 2021 NSDASTIKENQFDPPIVARYIRISPTRA-YNRPTLRLELQGCEVNGCSTPLGMENGKIEN 2079

Query: 602  STI 604
              I
Sbjct: 2080 KQI 2082


>gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo
           sapiens]
          Length = 775

 Score =  138 bits (347), Expect = 2e-32
 Identities = 123/444 (27%), Positives = 189/444 (42%), Gaps = 70/444 (15%)

Query: 7   LLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQR 66
           LL  VL L+L  AGA + D CG T+     G LTS  YP +Y  S  CEW I+     +R
Sbjct: 52  LLLLVLLLLLEDAGAQQGDGCGHTVLGPESGTLTSINYPQTYPNSTVCEWEIRVKMG-ER 110

Query: 67  IMINFNPHFDLEDRD-CKYDYVEVFDGENENGHFRGKFCGKIAPP--PVVSSGPFLFIKF 123
           + I F   FD+ED D C ++Y+ +++G   +    GK+CG        + S G  + + F
Sbjct: 111 VRIKFGD-FDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIESKGNEITLLF 169

Query: 124 VSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMS 183
           +S     G GF   Y +  +                         + + C          
Sbjct: 170 MSGIHVSGRGFLASYSVIDK------------------------QDLITC---------- 195

Query: 184 EIILEFESFDLEPDSNP--PGGMFCRYDRLE--IWDGFPDVGPHIGRYCGQKTPGRIRSS 239
              L+  S  LEP+ +   P G    +  +   I  G+ D  P     C       + S+
Sbjct: 196 ---LDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSP----LCMAGVHAGVVSN 248

Query: 240 S--GILSMVFYTDSAIAKEGFSANYSVLQSSVSED---FK---CMEALGMESGEIHSDQI 291
           +  G +S+V        +   + N + +   +S     FK   C   LGMESG I   QI
Sbjct: 249 TLGGQISVVISKGIPYYESSLANNVTSVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQI 308

Query: 292 TASSQYS--------TNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQG 343
           TASS            +W  +++RL  P   W        +W+Q+DL   + +T + T G
Sbjct: 309 TASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTG 368

Query: 344 AISKETKKKYYVKTYKIDVSSNGEDWITIKEGN--KPVLFQGNTNPTDVVVAVFPKPLIT 401
           +   E    YYV  Y+I  S +G+ W   +E    +  +FQGN +    V   F  P+I 
Sbjct: 369 STMVE--HNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIA 426

Query: 402 RFVRIKPATWETGISMRFEVYGCK 425
           RF+R+ P  W+  I+M+ E+ GC+
Sbjct: 427 RFIRVNPTQWQQKIAMKMELLGCQ 450



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 59/163 (36%), Positives = 86/163 (52%), Gaps = 13/163 (7%)

Query: 431 CSGMLGMVSGLISDSQITSSN-------QGDRN-WMPENIRLVTSRSGWALPPAPHSYIN 482
           C G LGM SG+I+D QIT+S+        G  N W P+  RL      WA   A   Y  
Sbjct: 292 CYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAF-ATDEY-- 348

Query: 483 EWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEG 542
           +WLQIDL +EK + GII  G    E+  ++  ++I YS++G  W +  +    + K F+G
Sbjct: 349 QWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQG 408

Query: 543 NNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCE 584
           N +Y       F P +  RFIR+ P +     + ++MELLGC+
Sbjct: 409 NKDYHQDVRNNFLPPIIARFIRVNPTQ-WQQKIAMKMELLGCQ 450


>gi|126091152 cubilin [Homo sapiens]
          Length = 3623

 Score =  132 bits (332), Expect = 9e-31
 Identities = 83/250 (33%), Positives = 123/250 (49%), Gaps = 20/250 (8%)

Query: 27   CGDTIKI---ESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDC 82
            CG  + I   +S GY+TSP +PH+Y P   C W++ AP P  RI + F   FD+E   +C
Sbjct: 2217 CGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAP-PETRIQLQFEDRFDIEVTPNC 2275

Query: 83   KYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142
              +Y+E+ DG + +     KFCG   P    SSG  ++++F SD      GF  +Y I  
Sbjct: 2276 TSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI-- 2333

Query: 143  RGPECSQNYTTPSGVIKSPGFPE-KYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPP 201
               +C       SGV++S G P   Y ++L C + +       + + FE F+L+  S   
Sbjct: 2334 --AQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSG-- 2389

Query: 202  GGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN 261
                C  D +EIWD     G  +GRYCG   P  I +SS    + F TD ++   GF   
Sbjct: 2390 ----CEKDFVEIWDNHTS-GNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLR 2444

Query: 262  YSVLQSSVSE 271
            +   +SS+ E
Sbjct: 2445 F---ESSMEE 2451



 Score =  130 bits (326), Expect = 5e-30
 Identities = 86/275 (31%), Positives = 123/275 (44%), Gaps = 19/275 (6%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
            CGD +  E  G + SP +P+ Y     C W I  P   Q I++NF          C+ DY
Sbjct: 817  CGDELTGE--GVIRSPFFPNVYPGERTCRWTIHQPQS-QVILLNFTVFEIGSSAHCETDY 873

Query: 87   VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146
            VE+            K+CG   P  + S   FL++ FV    T   GF  ++        
Sbjct: 874  VEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSA--EDLA 931

Query: 147  CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
            C +  T  +G I+SPG P  YP+ + CT+ +       I L FE+F LE   N      C
Sbjct: 932  CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN------C 985

Query: 207  RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
              D LE++D   D    +GRYCG+  P  + SS   L +VF TDS +A EGF  NY  + 
Sbjct: 986  TNDYLEVYD--TDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAIS 1043

Query: 267  SSVSEDFKCMEALGMESGEIHSDQITASSQYSTNW 301
            ++ +    C++    + G   S      + Y  NW
Sbjct: 1044 AATA----CLQDYTDDLGTFTSPNF--PNNYPNNW 1072



 Score =  126 bits (317), Expect = 5e-29
 Identities = 86/235 (36%), Positives = 114/235 (48%), Gaps = 11/235 (4%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKYD 85
            CG+ I  ES G + SPG+P+ Y     C W I    P   I + F   F LE   +C  D
Sbjct: 932  CGE-ILTESTGTIQSPGHPNVYPHGINCTWHILV-QPNHLIHLMFET-FHLEFHYNCTND 988

Query: 86   YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
            Y+EV+D ++E     G++CGK  PP + SSG  L + FV+D +    GF I YE      
Sbjct: 989  YLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAAT 1046

Query: 146  ECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
             C Q+YT   G   SP FP  YPN+ EC Y +       I + F +F LE      G  +
Sbjct: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLE---EAIGNYY 1103

Query: 206  CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSA 260
               D LEI DG  +  P +G + G   P  I S S  L + F +D    + GFSA
Sbjct: 1104 T--DFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSA 1156



 Score =  126 bits (317), Expect = 5e-29
 Identities = 77/238 (32%), Positives = 117/238 (49%), Gaps = 12/238 (5%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDCKYD 85
            CG  I   S   ++SP +P +Y  ++ C W+IQA  P   I ++F  HF+LE    C  D
Sbjct: 1620 CGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFT-HFELERSTTCARD 1678

Query: 86   YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
            +VE+ DG +E+   RG++CG   P P+ S    L ++FVSD      GF     +     
Sbjct: 1679 FVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGF--HTTVTASVS 1736

Query: 146  ECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205
             C   +    G+  SPG+P+ YP ++EC + + +   + + L F SF LE   +      
Sbjct: 1737 ACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQD------ 1790

Query: 206  CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSG-ILSMVFYTDSAIAKEGFSANY 262
            C  D +EI +G    G  +GRYCG   P    S  G  L + F +D + +  GF A +
Sbjct: 1791 CSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATF 1847



 Score =  116 bits (290), Expect = 7e-26
 Identities = 81/255 (31%), Positives = 122/255 (47%), Gaps = 18/255 (7%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
            CG   +  S G + SP YP  Y  +  C W+I+  D   R+++NF   FDLE +D     
Sbjct: 1510 CGGIFQAPS-GEIHSPNYPSPYRSNTDCSWVIRV-DRNHRVLLNFTD-FDLEPQD---SC 1563

Query: 87   VEVFDGENENGHFRGKFCGKIA-PPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGP 145
            +  +DG +       + CG+     P+VSSG  LF++F S       GF  ++     G 
Sbjct: 1564 IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGH 1623

Query: 146  ECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFA-PKMSEIILEFESFDLEPDSNPPGGM 204
              + ++ T    + SP FP  YPN+  C++I+ A P ++ I L F  F+LE  +      
Sbjct: 1624 ILTSSFDT----VSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTT----- 1674

Query: 205  FCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
             C  D +EI DG  +  P  GRYCG   P  I S S  L++ F +DS+I+  GF    + 
Sbjct: 1675 -CARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTA 1733

Query: 265  LQSSVSEDFKCMEAL 279
              S+    F   E +
Sbjct: 1734 SVSACGGTFYMAEGI 1748



 Score =  112 bits (281), Expect = 8e-25
 Identities = 76/245 (31%), Positives = 114/245 (46%), Gaps = 21/245 (8%)

Query: 27   CGDTIKI-ESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLED-RDCKY 84
            CG  ++  ++P +L SPG+P SY     C WLIQAPD    + I      D+E  R C Y
Sbjct: 1978 CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNIL---SLDIESHRTCAY 2034

Query: 85   DYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRG 144
            D + + DG+N         CG+  P P+ S+G ++FI+F SD     AGF+  +      
Sbjct: 2035 DSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFH----- 2089

Query: 145  PECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGM 204
              C        G+I SP +PE YP++L C++ V       I + FE    +P   P G  
Sbjct: 2090 KSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFE----QPFQIPNGDS 2145

Query: 205  FCRY-DRLEIWDG----FPDVGP--HIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEG 257
             C   D L + +G     P +GP    G +CG      + +S   + + F +D +   +G
Sbjct: 2146 SCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQG 2205

Query: 258  FSANY 262
            F   Y
Sbjct: 2206 FKIKY 2210



 Score =  112 bits (281), Expect = 8e-25
 Identities = 86/297 (28%), Positives = 131/297 (44%), Gaps = 39/297 (13%)

Query: 27   CGDTIKIESPGYLTSPGYP--HSYHPSEKCEWLIQAPDP-YQRIMINFNPHFDLEDRDCK 83
            CG ++     G  TSPGY    +Y  +  CEW +  P+     I I+F   +    +DC+
Sbjct: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQ 2629

Query: 84   YDYVEVFDGENENGHFRGKFCGKIAPP-PVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142
            +D +E   G+ + G    + CG   P  P+V     ++I FV++      GF  +Y    
Sbjct: 2630 FDVLEFRVGDAD-GPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSF-- 2686

Query: 143  RGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPG 202
               +C       SGVI SP +P  Y +   C+ ++ AP+   I L F  FD+EP +    
Sbjct: 2687 --TDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTT--- 2741

Query: 203  GMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
               C +D + + +G     P IG+YCG   P  I+S S  L + F +D ++   GF A +
Sbjct: 2742 ---CAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATW 2798

Query: 263  SVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPEN---GWT 316
            +             + LG   G  HSD  T  S +   W       N+PEN    WT
Sbjct: 2799 NT------------QTLGC-GGIFHSDNGTIRSPH---WPQ-----NFPENSRCSWT 2834



 Score =  111 bits (278), Expect = 2e-24
 Identities = 96/351 (27%), Positives = 157/351 (44%), Gaps = 35/351 (9%)

Query: 27  CGDTIK-IESPGYLTSP--GYPHSYHPSEKCEWLIQAP-DPYQRIMINFNPHFDLEDRD- 81
           CG+++  I       SP  GY H  +    C W+I+       RI   F   F LE  D 
Sbjct: 474 CGESLSGINGSFSYRSPDVGYVHDVN----CFWVIKTEMGKVLRITFTF---FRLESMDN 526

Query: 82  CKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIF 141
           C +++++V+DG++ +    G+FCG   P  ++SS   L+    S++  +G GF++R+E  
Sbjct: 527 CPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWE-- 584

Query: 142 KRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPP 201
            + PEC    T P G IKSPG+P  YP   +C +IV       +   F +  LE   +  
Sbjct: 585 TQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD-- 642

Query: 202 GGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN 261
               C  D LEI DG     P +G++C   +   ++++     + F++DS I+ +GF   
Sbjct: 643 ----CNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHIT 698

Query: 262 YSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNW-------SAERSRLNYPENG 314
           Y    S    D +C        GE+   +++    ++            E+ ++N+    
Sbjct: 699 YLTSPS----DLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVE 754

Query: 315 WTPGEDSYREWIQVDLG--LLRFVTAVGTQGAISKETKKKYYVKTYKIDVS 363
                DS + +I+V  G  LL  V   GT   I   T   +    +KID S
Sbjct: 755 LQCQSDSSQNYIEVRDGETLLGKVCGNGTISHIKSITNSVWI--RFKIDAS 803



 Score =  110 bits (275), Expect = 4e-24
 Identities = 77/255 (30%), Positives = 117/255 (45%), Gaps = 23/255 (9%)

Query: 17   APAGAFRND---KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNP 73
            APA  F      +CG      S GY+ SP YP  Y  +  C ++I+A +P   +++ F  
Sbjct: 2907 APAQGFSASFVSRCGSNFTGPS-GYIISPNYPKQYDNNMNCTYVIEA-NPLSVVLLTF-V 2963

Query: 74   HFDLEDRD-----CKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYE 128
             F LE R      C  D V +  G +         CG   P P+  +GP L + F S+ +
Sbjct: 2964 SFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQ 3022

Query: 129  THGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFP-EKYPNSLECTYIVFAPKMSEIIL 187
                GF   Y I      C   +   SG+I SP +    YPN + C Y +       I L
Sbjct: 3023 ITDFGFKFSYRIIS----CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIEL 3078

Query: 188  EFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVF 247
            +F  FD+ P ++      C +D L I+DG     P +G++CG K P  ++SS+  + +VF
Sbjct: 3079 KFSDFDVVPSTS------CSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVF 3132

Query: 248  YTDSAIAKEGFSANY 262
             TDS    +G+  ++
Sbjct: 3133 KTDSFQTAKGWKMSF 3147



 Score =  110 bits (274), Expect = 5e-24
 Identities = 72/250 (28%), Positives = 117/250 (46%), Gaps = 11/250 (4%)

Query: 21   AFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEK-CEWLIQAPDPYQRIMINFNPHFDLED 79
            ++R   CG      S G +TSP Y ++ +P++  C + I   D  + I + F+    +  
Sbjct: 3031 SYRIISCGGVFNFSS-GIITSPAYSYADYPNDMHCLYTITVSDD-KVIELKFSDFDVVPS 3088

Query: 80   RDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE 139
              C +DY+ ++DG N +    GKFCG   PP V SS   + + F +D      G+ + + 
Sbjct: 3089 TSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFR 3148

Query: 140  IFKRGPE--CSQNYTTPSGVIKSPGFPEK--YPNSLECTYIVFAPKMSEIILEFESFDLE 195
                GP+  C    T  +    SP       Y  +L C +I+ AP    I L F +F LE
Sbjct: 3149 Q-TLGPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALE 3207

Query: 196  PDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAK 255
              S       C YD ++++DG  +     G +CG   P    SS   L++ F +D  + +
Sbjct: 3208 AASTRQR---CLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLER 3264

Query: 256  EGFSANYSVL 265
            EGF+A Y+++
Sbjct: 3265 EGFNATYTIM 3274



 Score =  109 bits (272), Expect = 8e-24
 Identities = 79/235 (33%), Positives = 116/235 (49%), Gaps = 19/235 (8%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLED-RDCKYD 85
            CG T  + + G   SPGYP  Y P+ +C W I +  P  R+ ++F   F LED +DC  D
Sbjct: 1738 CGGTFYM-AEGIFNSPGYPDIYPPNVECVWNIVS-SPGNRLQLSFIS-FQLEDSQDCSRD 1794

Query: 86   YVEVFDGENENGHFRGKFCGKIAPPPVVSS-GPFLFIKFVSDYETHGAGFSIRY-EIFKR 143
            +VE+ +G N  GH  G++CG   P    S  G  L+++F+SD    G GF   + +IF  
Sbjct: 1795 FVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFG- 1852

Query: 144  GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
                + N     G + SP +PE YP++    + V       +       D+E   N    
Sbjct: 1853 ----NDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQN---- 1904

Query: 204  MFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGF 258
              C YD+L I+DG       IG YCG +T     S+   L+  FY+DS+I+ +GF
Sbjct: 1905 --CYYDKLRIYDGPSIHARLIGAYCGTQTES-FSSTGNSLTFHFYSDSSISGKGF 1956



 Score =  108 bits (271), Expect = 1e-23
 Identities = 75/258 (29%), Positives = 118/258 (45%), Gaps = 32/258 (12%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKY-- 84
            CG  +  +  G +TSP YP +Y  +  C W +        I ++F   F + + D     
Sbjct: 2092 CGGYLHADR-GIITSPKYPETYPSNLNCSWHVLVQSGLT-IAVHFEQPFQIPNGDSSCNQ 2149

Query: 85   -DYVEVFDGEN----------ENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAG 133
             DY+ + +G +           NGHF    CG  A   + +S   +F++F+SD+   G G
Sbjct: 2150 GDYLVLRNGPDICSPPLGPPGGNGHF----CGSHASSTLFTSDNQMFVQFISDHSNEGQG 2205

Query: 134  FSIRYEIFKRGPECSQNY----TTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEF 189
            F I+YE   +   C  N        +G + SP  P  YP   +C +I+ AP  + I L+F
Sbjct: 2206 FKIKYE--AKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQF 2263

Query: 190  ES-FDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFY 248
            E  FD+E   N      C  + LE+ DG     P + ++CG   P    SS  ++ + F 
Sbjct: 2264 EDRFDIEVTPN------CTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFR 2317

Query: 249  TDSAIAKEGFSANYSVLQ 266
            +D++    GF A YS+ Q
Sbjct: 2318 SDNSPTHVGFKAKYSIAQ 2335



 Score =  107 bits (267), Expect = 3e-23
 Identities = 65/228 (28%), Positives = 101/228 (44%), Gaps = 11/228 (4%)

Query: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENEN 96
           G + SPGYP +Y P   C W++    P   +   F         DC  DY+E+ DG    
Sbjct: 599 GSIKSPGYPGNYPPGRDCVWIV-VTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQ 657

Query: 97  GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSG 156
               GKFC   + PP+ ++GPF  I F SD +    GF I Y        C  NYT P G
Sbjct: 658 DPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEG 717

Query: 157 VIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG 216
            +  P     + ++ +C Y++  P+  +I + F   +L+          C+ D  + +  
Sbjct: 718 ELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQ----------CQSDSSQNYIE 767

Query: 217 FPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSV 264
             D    +G+ CG  T   I+S +  + + F  D+++ K  F A Y V
Sbjct: 768 VRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQV 815



 Score =  103 bits (258), Expect = 4e-22
 Identities = 74/248 (29%), Positives = 112/248 (45%), Gaps = 34/248 (13%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD----- 81
            CG  +   S G   SP YP  Y+ S +C W +++         +    F+LE +D     
Sbjct: 1165 CGGNLTTSS-GTFISPNYPMPYYHSSECYWWLKS---------SHGSAFELEFKDFHLEH 1214

Query: 82   ---CKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY 138
               C  DY+ V+DG + N H   + CG   PP + SSG  +FIK  +D    G GF   Y
Sbjct: 1215 HPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274

Query: 139  -EIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPD 197
             +  +     +Q Y    G+++S G+P  Y  +  C + + A   + +   F +FDLE  
Sbjct: 1275 RQTCENVVIVNQTY----GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHH 1330

Query: 198  SNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKE- 256
             N      C  D LE++DG       +GRYCG   P    ++S  L ++  TD    +E 
Sbjct: 1331 IN------CSTDYLELYDG----PRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREK 1380

Query: 257  GFSANYSV 264
            GF   + V
Sbjct: 1381 GFQMQWFV 1388



 Score =  103 bits (258), Expect = 4e-22
 Identities = 69/235 (29%), Positives = 112/235 (47%), Gaps = 15/235 (6%)

Query: 27   CGDTIKIE-SPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYD 85
            CG T     +P  ++SP       P   C W+I +P P+Q++ I       L  +DC  +
Sbjct: 3278 CGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSP-PHQQVKITVWA-LQLTSQDCTQN 3335

Query: 86   YVEVFDGENENGHFRGKFCGKIAP--PPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
            Y+++ D    +G+ R +FCG+ A   P   SS     + F S      +  S  Y+I   
Sbjct: 3336 YLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQI--- 3392

Query: 144  GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
              +C+++Y    G ++SPG+P+ Y N  +CT  + AP+   I L F S  +E        
Sbjct: 3393 -ADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIE------NS 3445

Query: 204  MFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGF 258
            + CR D LE+ +G     P +G+YCG   P  + S +  L + F +DS  +  G+
Sbjct: 3446 VECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY 3500



 Score =  103 bits (257), Expect = 5e-22
 Identities = 79/250 (31%), Positives = 119/250 (47%), Gaps = 17/250 (6%)

Query: 37   GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKY--DYVEVFDGEN 94
            G  TSP +P++Y  + +C + I      Q I ++F  +F LE+    Y  D++E+ DG  
Sbjct: 1057 GTFTSPNFPNNYPNNWECIYRITVRTG-QLIAVHFT-NFSLEEAIGNYYTDFLEIRDGGY 1114

Query: 95   ENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTP 154
            E     G F G   PP ++S    L++KF SD     +GFS  ++    G  C  N TT 
Sbjct: 1115 EKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTG--CGGNLTTS 1172

Query: 155  SGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIW 214
            SG   SP +P  Y +S EC + + +   S   LEF+ F LE   N      C  D L ++
Sbjct: 1173 SGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPN------CTLDYLAVY 1226

Query: 215  DGFPDVGPH-IGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSS---VS 270
            DG P    H + + CG + P  IRSS   + +   TD      GF A Y     +   V+
Sbjct: 1227 DG-PSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIVN 1285

Query: 271  EDFKCMEALG 280
            + +  +E++G
Sbjct: 1286 QTYGILESIG 1295



 Score =  101 bits (251), Expect = 2e-21
 Identities = 68/242 (28%), Positives = 115/242 (47%), Gaps = 14/242 (5%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD--CKY 84
            CG     ++ G + SP +P ++  + +C W        + + I+F+ +F +   D  C+ 
Sbjct: 2805 CGGIFHSDN-GTIRSPHWPQNFPENSRCSWTA-ITHKSKHLEISFDNNFLIPSGDGQCQN 2862

Query: 85   DYVEVFDGENE-NGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
             +V+V+ G  E +       CG +AP PV++        F S  E    GFS  +     
Sbjct: 2863 SFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFV---- 2917

Query: 144  GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
               C  N+T PSG I SP +P++Y N++ CTY++ A  +S ++L F SF LE  S   G 
Sbjct: 2918 -SRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGS 2976

Query: 204  MFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYS 263
              C  D + I  G+  +       CG + P  +  +  +L + FY++  I   GF  +Y 
Sbjct: 2977 --CVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYR 3033

Query: 264  VL 265
            ++
Sbjct: 3034 II 3035



 Score = 99.4 bits (246), Expect = 9e-21
 Identities = 66/241 (27%), Positives = 116/241 (48%), Gaps = 20/241 (8%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYD 85
            CG  +   + G  +SPG+P+ Y P+++C W I+  DP   I +  +  FD+E    C +D
Sbjct: 1391 CGGELS-GATGSFSSPGFPNRYPPNKECIWYIRT-DPGSSIQLTIHD-FDVEYHSRCNFD 1447

Query: 86   YVEVFDGENENGHFRGKFCGKIAPP---PVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142
             +E++ G + +     + C + +P     V S+G  L I+F +D   +G GF+  ++   
Sbjct: 1448 VLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVT 1507

Query: 143  RGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPG 202
             G  C   +  PSG I SP +P  Y ++ +C++++   +   ++L F  FDLEP  +   
Sbjct: 1508 GG--CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDS--- 1562

Query: 203  GMFCRYDRLEIWDGFPDVGPHIGRYCG-QKTPGRIRSSSGILSMVFYTDSAIAKEGFSAN 261
               C    +  +DG       + R CG ++    I SS   L + F +  +    GF A 
Sbjct: 1563 ---C----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQ 1615

Query: 262  Y 262
            +
Sbjct: 1616 F 1616



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 66/223 (29%), Positives = 101/223 (45%), Gaps = 10/223 (4%)

Query: 37   GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENEN 96
            G L SPG+P +Y   + C   + AP  +  I + F+        +C+ D++EV +G N N
Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHT-ISLFFHSLGIENSVECRNDFLEVRNGSNSN 3462

Query: 97   GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSG 156
                GK+CG + P PV S    L+++F SD  T   G+ I +     G  C        G
Sbjct: 3463 SPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSG--CGGTLYGDRG 3520

Query: 157  VIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDG 216
               SPG+P  YPN+  C +++ AP    + + F    ++     PG   C  + L ++DG
Sbjct: 3521 SFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISID----DPGD--CVQNYLTLYDG 3574

Query: 217  FPDVGPHIGRYCGQKTP-GRIRSSSGILSMVFYTDSAIAKEGF 258
                 P  G YCG  T      +SS  + + F+ D A     F
Sbjct: 3575 PNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAF 3617



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 76/293 (25%), Positives = 133/293 (45%), Gaps = 22/293 (7%)

Query: 26   KCGDTIKIESPGYLTSPGYPH-SYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CK 83
            +CG  +  +S G + S G+P   Y  +  CEW +Q    +  + I+F   F+L++   C+
Sbjct: 2335 QCGGRVPGQS-GVVESIGHPTLPYRDNLFCEWHLQGLSGHY-LTISFED-FNLQNSSGCE 2391

Query: 84   YDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
             D+VE++D    +G+  G++CG   P  + +S     ++FV+D     +GF +R+E    
Sbjct: 2392 KDFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSME 2450

Query: 144  GPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGG 203
              EC  +     G   SP +P   P+   C + + AP+   I L F +  L    +    
Sbjct: 2451 --ECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPS---- 2504

Query: 204  MFCRYDRLEIWDGFPDVGPHIGRYCGQ-KTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262
              C  + + +++G     P + + C        I+SS   + ++F+TD +    GF+A+Y
Sbjct: 2505 --CNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY 2562

Query: 263  SVLQSSVSEDFKCMEAL-GMESGEIHSDQITASSQYSTNWSAERSRLNYPENG 314
                 + SED  C  +L     G   S        YS N + E + L+ P  G
Sbjct: 2563 -----TSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWT-LSNPNQG 2609



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 64/242 (26%), Positives = 111/242 (45%), Gaps = 30/242 (12%)

Query: 37   GYLTSPGYPHSYHPSEKCEWLIQAPDPYQ---RIMINFNPHFDLED-RDCKYDYVEVFDG 92
            G + SP +P +Y  +   +W +     +    RI+       D+E+ ++C YD + ++DG
Sbjct: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRIL-----EMDIEEIQNCYYDKLRIYDG 1915

Query: 93   ENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYT 152
             + +    G +CG        S+G  L   F SD    G GF + +      P+      
Sbjct: 1916 PSIHARLIGAYCG-TQTESFSSTGNSLTFHFYSDSSISGKGFLLEW-FAVDAPDGVLPTI 1973

Query: 153  TPSG------------VIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
             P               + SPG+P+ Y N ++CT+++ AP  S + L   S D+E     
Sbjct: 1974 APGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPD-STVELNILSLDIESHRT- 2031

Query: 201  PGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSA 260
                 C YD L I DG  ++   +   CG++ PG IRS+   + + F +DS++ + GF+A
Sbjct: 2032 -----CAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNA 2086

Query: 261  NY 262
            ++
Sbjct: 2087 SF 2088



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 60/211 (28%), Positives = 95/211 (45%), Gaps = 22/211 (10%)

Query: 48   YHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD----CKYDYVEVFDGENENGHFRGKF 103
            Y  +  C W+I AP   + I + FN  F LE       C YDYV+++DG++EN +  G F
Sbjct: 3179 YDKNLNCVWIIIAP-VNKVIHLTFNT-FALEAASTRQRCLYDYVKLYDGDSENANLAGTF 3236

Query: 104  CGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGF 163
            CG   P P +SSG FL ++F+SD      GF+  Y I       + N T     I SP  
Sbjct: 3237 CGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNS 3296

Query: 164  PEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPH 223
             +       CT+++ +P   ++ +   +  L           C  + L++ D     G  
Sbjct: 3297 SDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-------CTQNYLQLQDSPQGHGNS 3349

Query: 224  IGRYCGQKTPGRIRSSSGILSMVFYTDSAIA 254
              ++CG       R++S +   VFY+  + A
Sbjct: 3350 RFQFCG-------RNASAV--PVFYSSMSTA 3371



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 71/245 (28%), Positives = 103/245 (42%), Gaps = 15/245 (6%)

Query: 25   DKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKY 84
            ++CG  ++  S G  TSP YP+       CEW I AP+  +RI + FN         C  
Sbjct: 2450 EECGGDLQ-GSIGTFTSPNYPNPNPHGRICEWRITAPEG-RRITLMFNNLRLATHPSCNN 2507

Query: 85   DYVEVFDGENENGHFRGKFCGKI-APPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKR 143
            ++V VF+G   N     K C  +     + SSG  + + F +D      GF+  Y   + 
Sbjct: 2508 EHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED 2567

Query: 144  GPECSQNYTTPSGVIKSPGFP--EKYPNSLECTYIVFAPKM--SEIILEFESFDLEPDSN 199
                     TP G   SPG+     Y  +L C + +  P    S I + FE F LE   +
Sbjct: 2568 AVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQD 2627

Query: 200  PPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPG-RIRSSSGILSMVFYTDSAIAKEGF 258
                  C++D LE   G  D GP + R CG   P   +      + + F T+  +   GF
Sbjct: 2628 ------CQFDVLEFRVGDAD-GPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGF 2680

Query: 259  SANYS 263
             A YS
Sbjct: 2681 HAKYS 2685



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 38/114 (33%), Positives = 61/114 (53%), Gaps = 3/114 (2%)

Query: 27   CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86
            CG T+  +  G  TSPGYP +Y  +  CEW++ AP   + + INF      +  DC  +Y
Sbjct: 3511 CGGTLYGDR-GSFTSPGYPGTYPNNTYCEWVLVAPAG-RLVTINFYFISIDDPGDCVQNY 3568

Query: 87   VEVFDGENENGHFRGKFCG-KIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE 139
            + ++DG N +    G +CG   +  P V+S   +FIKF +DY    + F + ++
Sbjct: 3569 LTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWD 3622


>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
          Length = 449

 Score =  130 bits (328), Expect = 3e-30
 Identities = 88/261 (33%), Positives = 128/261 (49%), Gaps = 23/261 (8%)

Query: 9   CAVLALVLAPAG----AFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPY 64
           C +LA+ L   G    A    KCG  +   S G  +SP +P  Y  + +C WLI   +  
Sbjct: 8   CLLLAVALLGPGLQAQAMEGVKCGGVLSAPS-GNFSSPNFPRLYPYNTECSWLIVVAEG- 65

Query: 65  QRIMINFNPHFDLEDRD-CKYDYVEVFDGEN-ENGHFRGKFCGKIAPPPVVSSGPFLFIK 122
             +++ F+  FDLE  D C +D++E+++G + + G+  G+FCGK+ PPP  SS   + + 
Sbjct: 66  SSVLLTFHA-FDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVI 124

Query: 123 FVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKM 182
           F SD      GFS  Y+       C    T  SGV+ SP +P  YPNS+EC +++ A   
Sbjct: 125 FHSDKHVASHGFSAGYQ----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGP 180

Query: 183 SEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG-RYCGQKTPGRIRSSSG 241
           + + L F  F +E      G   C YD + +  G    GP  G  YCG   P  + S   
Sbjct: 181 AHVKLVFVDFQVE------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGH 231

Query: 242 ILSMVFYTDSAIAKEGFSANY 262
            L +VF +D  I   GF A Y
Sbjct: 232 ELQVVFKSDFNIGGRGFKAYY 252



 Score =  129 bits (323), Expect = 1e-29
 Identities = 79/246 (32%), Positives = 120/246 (48%), Gaps = 14/246 (5%)

Query: 19  AGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE 78
           +  ++ D CG  +   S G LTSP YP++Y  S +C W+I+A  P    ++  +  F +E
Sbjct: 137 SAGYQKDVCGGVLTGLS-GVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD--FQVE 193

Query: 79  -DRDCKYDYVEVFDGENEN-GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSI 136
            + +C YDYV V  G     GH    +CG   PP +VS G  L + F SD+   G GF  
Sbjct: 194 GNEECTYDYVAVLGGPGPTRGHH---YCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250

Query: 137 RYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEP 196
            Y       EC + Y    G   SP +P  YPN++ C + +  P   ++ + F   DLE 
Sbjct: 251 YYF----SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEE 306

Query: 197 DSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKE 256
            ++      C +D L  +DG  +  P +G +CG   P  + SS   L ++ +TD +  + 
Sbjct: 307 PNSLT--KTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRR 364

Query: 257 GFSANY 262
           GFS  Y
Sbjct: 365 GFSVAY 370


>gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Homo
           sapiens]
          Length = 335

 Score =  115 bits (287), Expect = 2e-25
 Identities = 107/353 (30%), Positives = 158/353 (44%), Gaps = 81/353 (22%)

Query: 246 VFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYST-----N 300
           VF + +    +G++ N+         + KC+E LG+E+G I + QI ASS   T     +
Sbjct: 49  VFPSYTCTCLKGYAGNHC--------ETKCVEPLGLENGNIANSQIAASSVRVTFLGLQH 100

Query: 301 WSAERSRLNYPE--NGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTY 358
           W  E +RLN     N WTP  +    WIQV+L    +VT V TQGA    + +  Y+K +
Sbjct: 101 WVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHE--YLKAF 158

Query: 359 KIDVSSNGEDWITIKEGNKPVL-FQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISM 417
           K+  S NG ++  I + NK    F GN N   V V +F  P+  ++VR+ P +  T  ++
Sbjct: 159 KVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTL 218

Query: 418 RFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDR------NWMPENIRLVTSRSGW 471
           RFE+ GC++    C+  LG+ +  I D QIT+S+          +W P   RL   + G 
Sbjct: 219 RFELLGCELNG--CANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARL--DKQGN 274

Query: 472 ALPPAPHSYIN-EWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIM 530
                  SY N +WLQI  G                                  +W    
Sbjct: 275 FNAWVAGSYGNDQWLQIFPG----------------------------------NW---- 296

Query: 531 DDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGC 583
           D+   K       N ++TP L        R++RI P  A H  + LR+ELLGC
Sbjct: 297 DNHSHK------KNLFETPIL-------ARYVRILPV-AWHNRIALRLELLGC 335



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 59/181 (32%), Positives = 95/181 (52%), Gaps = 11/181 (6%)

Query: 431 CSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSRSGWALPPAPHSYI-NEW 484
           C   LG+ +G I++SQI +S+      G ++W+PE  RL  +R+G      P S   N W
Sbjct: 70  CVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARL--NRAGMVNAWTPSSNDDNPW 127

Query: 485 LQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNN 544
           +Q++L     V G++ QG     +  +++ FK+ YS NG ++  I D +K K K F GN 
Sbjct: 128 IQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNK-KHKEFVGNW 186

Query: 545 NYDTPELRTFPA-LSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVIDST 603
           N +   +  F   +  +++R+YP  + H    LR ELLGCE+ G    L  +  ++ D  
Sbjct: 187 NKNAVHVNLFETPVEAQYVRLYP-TSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQ 245

Query: 604 I 604
           I
Sbjct: 246 I 246


>gi|10518506 coagulation factor VIII isoform b precursor [Homo
           sapiens]
          Length = 216

 Score =  113 bits (283), Expect = 4e-25
 Identities = 70/211 (33%), Positives = 111/211 (52%), Gaps = 10/211 (4%)

Query: 380 LFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVS 439
           +F GN + + +   +F  P+I R++R+ P  +    ++R E+ GC +    CS  LGM S
Sbjct: 9   VFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMES 66

Query: 440 GLISDSQITSSNQGDR---NWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVR 496
             ISD+QIT+S+        W P   RL       A  P  ++   EWLQ+D  +   V 
Sbjct: 67  KAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNP-KEWLQVDFQKTMKVT 125

Query: 497 GIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-P 555
           G+  QG K     +++++F I  S +G  W +   +   K K F+GN +  TP + +  P
Sbjct: 126 GVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNG--KVKVFQGNQDSFTPVVNSLDP 183

Query: 556 ALSTRFIRIYPERATHGGLGLRMELLGCEVE 586
            L TR++RI+P+   H  + LRME+LGCE +
Sbjct: 184 PLLTRYLRIHPQSWVH-QIALRMEVLGCEAQ 213



 Score =  103 bits (257), Expect = 5e-22
 Identities = 62/159 (38%), Positives = 83/159 (52%), Gaps = 7/159 (4%)

Query: 275 CMEALGMESGEIHSDQITASSQYST---NWSAERSRLNYP--ENGWTPGEDSYREWIQVD 329
           C   LGMES  I   QITASS ++     WS  ++RL+     N W P  ++ +EW+QVD
Sbjct: 58  CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 117

Query: 330 LGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTD 389
                 VT V TQG  S  T    YVK + I  S +G  W    +  K  +FQGN +   
Sbjct: 118 FQKTMKVTGVTTQGVKSLLTSM--YVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 175

Query: 390 VVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITD 428
            VV     PL+TR++RI P +W   I++R EV GC+  D
Sbjct: 176 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 214



 Score = 32.7 bits (73), Expect = 1.00
 Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 5/52 (9%)

Query: 555 PALSTRFIRIYPERATHGGLG--LRMELLGCEVEGGTTVLATEKPTVIDSTI 604
           P +  R+IR++P   TH  +   LRMEL+GC++   +  L  E   + D+ I
Sbjct: 26  PPIIARYIRLHP---THYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQI 74


>gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo
           sapiens]
          Length = 539

 Score =  110 bits (275), Expect = 4e-24
 Identities = 109/438 (24%), Positives = 190/438 (43%), Gaps = 62/438 (14%)

Query: 11  VLALVLAPAGAFR------NDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPY 64
           +LAL+LA +   R       D CG  +  +  G +TS  YP +Y     CE  I  P   
Sbjct: 19  LLALLLAVSAPLRLQAEELGDGCGHLVTYQDSGTMTSKNYPGTYPNHTVCEKTITVPKG- 77

Query: 65  QRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIA-PPPVVSSGPFLFIKF 123
           +R+++      D+E + C  DY+ +F   ++     G +CG +  P  ++ +   + ++F
Sbjct: 78  KRLILRLGD-LDIESQTCASDYL-LFTSSSDQ---YGPYCGSMTVPKELLLNTSEVTVRF 132

Query: 124 VSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMS 183
            S     G GF + Y         S ++      +      E+  + L+  Y  F P   
Sbjct: 133 ESGSHISGRGFLLTY--------ASSDHPDLITCL------ERASHYLKTEYSKFCPAGC 178

Query: 184 EIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGIL 243
             +    S ++  D      + C+     I  G   +   +G          I    GIL
Sbjct: 179 RDVAGDISGNMV-DGYRDTSLLCK---AAIHAGI--IADELGGQISVLQRKGISRYEGIL 232

Query: 244 SMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYST---- 299
           +     +  ++++G  ++   L +S      C  +L  E       QI ASS + +    
Sbjct: 233 A-----NGVLSRDGSLSDKRFLFTSNG----CSRSLSFEP----DGQIRASSSWQSVNES 279

Query: 300 ----NWSAERSRLNYPENGWTPGEDSY----REWIQVDLGLLRFVTAVGTQGAISKETKK 351
               +WS  ++RL      W  G+ S     REW+++DLG  + +T + T G  S ++  
Sbjct: 280 GDQVHWSPGQARLQDQGPSWASGDSSNNHKPREWLEIDLGEKKKITGIRTTG--STQSNF 337

Query: 352 KYYVKTYKIDVSSNGEDWITIKE--GNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPA 409
            +YVK++ ++  +N   W T K    N+  +FQGN+N  D V   F  P++ R+VR+ P 
Sbjct: 338 NFYVKSFVMNFKNNNSKWKTYKGIVNNEEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQ 397

Query: 410 TWETGISMRFEVYGCKIT 427
           TW   I+++ E+ GC+IT
Sbjct: 398 TWHQRIALKVELIGCQIT 415



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 48/157 (30%), Positives = 79/157 (50%), Gaps = 4/157 (2%)

Query: 443 SDSQITSSNQGDR-NWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIII 500
           S S  + +  GD+ +W P   RL      WA   + +++   EWL+IDLGE+K + GI  
Sbjct: 270 SSSWQSVNESGDQVHWSPGQARLQDQGPSWASGDSSNNHKPREWLEIDLGEKKKITGIRT 329

Query: 501 QGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF-PALST 559
            G        +++ F + + NN S WK        + K F+GN+N+  P    F P +  
Sbjct: 330 TGSTQSNFNFYVKSFVMNFKNNNSKWKTYKGIVNNEEKVFQGNSNFRDPVQNNFIPPIVA 389

Query: 560 RFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEK 596
           R++R+ P+   H  + L++EL+GC++  G   L   K
Sbjct: 390 RYVRVVPQ-TWHQRIALKVELIGCQITQGNDSLVWRK 425


>gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3
           precursor [Homo sapiens]
          Length = 533

 Score =  102 bits (255), Expect = 8e-22
 Identities = 67/237 (28%), Positives = 112/237 (47%), Gaps = 24/237 (10%)

Query: 26  KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKY 84
           +CG   K    G  TSP YP  Y P  +C ++I+A  P Q I + F+  + +E   +CK+
Sbjct: 40  QCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAA-PRQCIELYFDEKYSIEPSWECKF 98

Query: 85  DYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEI---- 140
           D++EV DG        G+FCG+  PP + SSG FL+IKF +D E    GFS RY      
Sbjct: 99  DHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDP 158

Query: 141 -------FKRGPECSQNYTTPSGVIKSPGFPEK----YPNSLECTYIVFAPKMSEIILEF 189
                   K  P C        G+++S    ++       +++C + + AP  S+I L F
Sbjct: 159 DFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRF 218

Query: 190 ESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQ-KTPGRIRSSSGILSM 245
             ++++  +       C+ + + ++DG   V     ++C        +R+  G++ M
Sbjct: 219 LDYEMQNSNE------CKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRM 269



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 53/160 (33%), Positives = 72/160 (45%), Gaps = 20/160 (12%)

Query: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEF-ESFDLEPDSNPPGGMFCRYDRLEIW 214
           G+  SP +P KYP   EC YI+ A     I L F E + +EP         C++D +E+ 
Sbjct: 51  GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWE------CKFDHIEVR 104

Query: 215 DGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDF- 273
           DG     P IGR+CGQ+ P  I+SS   L + F+ D  +   GFSA Y+       +D  
Sbjct: 105 DGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLG 164

Query: 274 ------KCMEALGMESGEIHSDQI------TASSQYSTNW 301
                  C   +G   G + S QI      TAS      W
Sbjct: 165 ALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKW 204


>gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2
           precursor [Homo sapiens]
          Length = 532

 Score =  102 bits (255), Expect = 8e-22
 Identities = 67/237 (28%), Positives = 112/237 (47%), Gaps = 24/237 (10%)

Query: 26  KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKY 84
           +CG   K    G  TSP YP  Y P  +C ++I+A  P Q I + F+  + +E   +CK+
Sbjct: 39  QCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAA-PRQCIELYFDEKYSIEPSWECKF 97

Query: 85  DYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEI---- 140
           D++EV DG        G+FCG+  PP + SSG FL+IKF +D E    GFS RY      
Sbjct: 98  DHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDP 157

Query: 141 -------FKRGPECSQNYTTPSGVIKSPGFPEK----YPNSLECTYIVFAPKMSEIILEF 189
                   K  P C        G+++S    ++       +++C + + AP  S+I L F
Sbjct: 158 DFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRF 217

Query: 190 ESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQ-KTPGRIRSSSGILSM 245
             ++++  +       C+ + + ++DG   V     ++C        +R+  G++ M
Sbjct: 218 LDYEMQNSNE------CKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRM 268



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 53/160 (33%), Positives = 72/160 (45%), Gaps = 20/160 (12%)

Query: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEF-ESFDLEPDSNPPGGMFCRYDRLEIW 214
           G+  SP +P KYP   EC YI+ A     I L F E + +EP         C++D +E+ 
Sbjct: 50  GIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWE------CKFDHIEVR 103

Query: 215 DGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDF- 273
           DG     P IGR+CGQ+ P  I+SS   L + F+ D  +   GFSA Y+       +D  
Sbjct: 104 DGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLG 163

Query: 274 ------KCMEALGMESGEIHSDQI------TASSQYSTNW 301
                  C   +G   G + S QI      TAS      W
Sbjct: 164 ALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKW 203


>gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Homo
           sapiens]
          Length = 525

 Score =  101 bits (251), Expect = 2e-21
 Identities = 58/220 (26%), Positives = 111/220 (50%), Gaps = 24/220 (10%)

Query: 26  KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR-DCKY 84
           +CG  ++  + G+  SP YP SY P+++C ++++A  P QRI + F+ H+ +E   +C++
Sbjct: 44  QCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAA-PRQRIELTFDEHYYIEPSFECRF 102

Query: 85  DYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYE----- 139
           D++EV DG         ++CG  +PP + S+G F++IKF SD E  G GF  +Y      
Sbjct: 103 DHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIPDP 162

Query: 140 -------IFKRGPECSQNYTTPSGVIKSPGFPE----KYPNSLECTYIVFAPKMSEIILE 188
                  I    P+C    +   G+++S    +    K   +++C + + A   ++I L 
Sbjct: 163 DFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKIYLR 222

Query: 189 FESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYC 228
           F  + +E  +       C+ + + ++DG   +     ++C
Sbjct: 223 FLDYQMEHSNE------CKRNFVAVYDGSSSIENLKAKFC 256



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 43/115 (37%), Positives = 59/115 (51%), Gaps = 7/115 (6%)

Query: 152 TTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEF-ESFDLEPDSNPPGGMFCRYDR 210
           T+  G   SP +P+ YP + EC YI+ A     I L F E + +EP         CR+D 
Sbjct: 51  TSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFE------CRFDH 104

Query: 211 LEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265
           LE+ DG     P I RYCG K+P  IRS+   + + F +D  +   GF A YS +
Sbjct: 105 LEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFI 159



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 1/63 (1%)

Query: 54  CEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVV 113
           C W I+A  P  +I + F  +      +CK ++V V+DG +   + + KFC  +A   ++
Sbjct: 207 CIWTIKAT-PKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVML 265

Query: 114 SSG 116
            +G
Sbjct: 266 KTG 268


>gi|62420886 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 57/157 (36%), Positives = 85/157 (54%), Gaps = 8/157 (5%)

Query: 275 CMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPEN--GWTPG----EDSYREWIQV 328
           C   LGM  G+I  + ITASSQ+S + +A+  RL+  E    W P      D  +E++Q+
Sbjct: 30  CRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQI 89

Query: 329 DLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPT 388
           DL  L F+T VGTQG  +     ++    YKI+ S +G  WI+ +  +   +  GN+NP 
Sbjct: 90  DLHTLHFITLVGTQGRHAGGHGIEF-APMYKINYSRDGTRWISWRNRHGKQVLDGNSNPY 148

Query: 389 DVVVAVFPKPLITRFVRIKPAT-WETGISMRFEVYGC 424
           D+ +     P++ RFVR  P T     + MR E+YGC
Sbjct: 149 DIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGC 185



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 47/159 (29%), Positives = 72/159 (45%), Gaps = 9/159 (5%)

Query: 431 CSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWA----LPPAPHSYINEWLQ 486
           C   LGM  G I D  IT+S+Q   +   +  RL +     A    +P  P   + E+LQ
Sbjct: 30  CRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDD-LKEFLQ 88

Query: 487 IDLGEEKIVRGIIIQGGKHRENKV-FMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNN 545
           IDL     +  +  QG     + + F   +KI YS +G+ W  I   ++   +  +GN+N
Sbjct: 89  IDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRW--ISWRNRHGKQVLDGNSN 146

Query: 546 -YDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGC 583
            YD       P +  RF+R  P       + +R+EL GC
Sbjct: 147 PYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGC 185


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,952,400
Number of Sequences: 37866
Number of extensions: 1322464
Number of successful extensions: 3357
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2289
Number of HSP's gapped (non-prelim): 469
length of query: 609
length of database: 18,247,518
effective HSP length: 108
effective length of query: 501
effective length of database: 14,157,990
effective search space: 7093152990
effective search space used: 7093152990
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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