Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 65506769

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|65506769 neurotrophic tyrosine kinase, receptor, type 2
isoform d precursor [Homo sapiens]
         (553 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo...  1154   0.0  
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...  1134   0.0  
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo...  1110   0.0  
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...  1089   0.0  
gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isofo...   975   0.0  
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo...   356   4e-98
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   352   4e-97
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   352   4e-97
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   247   2e-65
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   247   2e-65
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   235   7e-62
gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo sapi...    80   6e-15
gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo sap...    80   6e-15
gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo sap...    76   9e-14
gi|118572606 hemicentin 1 [Homo sapiens]                               75   1e-13
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   73   6e-13
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]              72   2e-12
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]              72   2e-12
gi|41582239 immunoglobulin superfamily containing leucine-rich r...    70   5e-12
gi|5031809 immunoglobulin superfamily containing leucine-rich re...    70   5e-12
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]         69   1e-11
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    69   1e-11
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ...    69   1e-11
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...    67   3e-11
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    67   4e-11
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    67   4e-11
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]             66   7e-11
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]             66   7e-11
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]             66   7e-11
gi|109150416 peroxidasin [Homo sapiens]                                64   3e-10

>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
           d precursor [Homo sapiens]
          Length = 553

 Score = 1154 bits (2986), Expect = 0.0
 Identities = 553/553 (100%), Positives = 553/553 (100%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480

Query: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
           VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540

Query: 541 KPDTWPRGSPKTA 553
           KPDTWPRGSPKTA
Sbjct: 541 KPDTWPRGSPKTA 553


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
           a precursor [Homo sapiens]
          Length = 838

 Score = 1134 bits (2933), Expect = 0.0
 Identities = 544/545 (99%), Positives = 545/545 (100%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480

Query: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
           VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540

Query: 541 KPDTW 545
           KPDT+
Sbjct: 541 KPDTF 545


>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
           e precursor [Homo sapiens]
          Length = 537

 Score = 1110 bits (2870), Expect = 0.0
 Identities = 537/553 (97%), Positives = 537/553 (97%), Gaps = 16/553 (2%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK               
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK--------------- 465

Query: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
            GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 466 -GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 524

Query: 541 KPDTWPRGSPKTA 553
           KPDTWPRGSPKTA
Sbjct: 525 KPDTWPRGSPKTA 537


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score = 1089 bits (2817), Expect = 0.0
 Identities = 528/545 (96%), Positives = 529/545 (97%), Gaps = 16/545 (2%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK               
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK--------------- 465

Query: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
            GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 466 -GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 524

Query: 541 KPDTW 545
           KPDT+
Sbjct: 525 KPDTF 529


>gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isoform
           b precursor [Homo sapiens]
          Length = 477

 Score =  975 bits (2521), Expect = 0.0
 Identities = 467/470 (99%), Positives = 467/470 (99%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWF 470
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK F  F
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGFVLF 470


>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
           c precursor [Homo sapiens]
          Length = 612

 Score =  356 bits (913), Expect = 4e-98
 Identities = 220/569 (38%), Positives = 308/569 (54%), Gaps = 79/569 (13%)

Query: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63

Query: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123

Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183

Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243

Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303

Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355

Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P  +   N     ++++
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411

Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
           +                  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456

Query: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
            R SKFGMK                GP +VIS ++DSASPLHHI++G  TPSS + GPD 
Sbjct: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500

Query: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTW 545
           V+IGMT+IPVIENPQYF   ++  KPDTW
Sbjct: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTW 529


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
           a precursor [Homo sapiens]
          Length = 839

 Score =  352 bits (904), Expect = 4e-97
 Identities = 220/569 (38%), Positives = 308/569 (54%), Gaps = 79/569 (13%)

Query: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63

Query: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123

Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183

Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243

Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303

Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355

Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P         +P+    
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402

Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
                + D     +  +  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456

Query: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
            R SKFGMK                GP +VIS ++DSASPLHHI++G  TPSS + GPD 
Sbjct: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500

Query: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTW 545
           V+IGMT+IPVIENPQYF   ++  KPDT+
Sbjct: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTY 529


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score =  352 bits (904), Expect = 4e-97
 Identities = 220/569 (38%), Positives = 308/569 (54%), Gaps = 79/569 (13%)

Query: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63

Query: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123

Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183

Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243

Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303

Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355

Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P         +P+    
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402

Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
                + D     +  +  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456

Query: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
            R SKFGMK                GP +VIS ++DSASPLHHI++G  TPSS + GPD 
Sbjct: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500

Query: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTW 545
           V+IGMT+IPVIENPQYF   ++  KPDT+
Sbjct: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTY 529


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score =  247 bits (631), Expect = 2e-65
 Identities = 178/536 (33%), Positives = 265/536 (49%), Gaps = 65/536 (12%)

Query: 7   WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
           WH  A        WL++    AA  CP +C        C   S G+        +S+   
Sbjct: 12  WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62

Query: 65  --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
              EN+TE++I NQ+ L+ +   D+     LRNLTIV SGL+FVA  AF     L  +N 
Sbjct: 63  PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122

Query: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESS 181
           + N L SLS K  + L L EL+L GNP  CSC + W++   +E       Q L C  +  
Sbjct: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181

Query: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
              PLA++   +CG+P+  +  PN +V+ G  + L C V G  +    W +  L      
Sbjct: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238

Query: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
             S    SL +T  N++SD + K ++C AEN VG  + SV + V F P    L +    H
Sbjct: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297

Query: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
           HWCIPF+V G P P+L+W +NG++LNE+ +I T+      N T  HGCL+L+ PTH+NNG
Sbjct: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357

Query: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
           +YTL+A N +G+    I A FM     D+    N  D I +   T+    GD   + +E 
Sbjct: 358 NYTLLAANPFGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDET 408

Query: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKS 477
           P   V+   G   L+V+A + +++       ++L L K  R +KF               
Sbjct: 409 P-FGVSVAVG---LAVFACLFLST-------LLLVLNKCGRRNKF--------------- 442

Query: 478 RQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 533
             G+   +V++ +D  A  LH ++ G ++ S +EG    +     +  +IENPQYF
Sbjct: 443 --GINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYF 491


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score =  247 bits (631), Expect = 2e-65
 Identities = 177/536 (33%), Positives = 263/536 (49%), Gaps = 59/536 (11%)

Query: 7   WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
           WH  A        WL++    AA  CP +C        C   S G+        +S+   
Sbjct: 12  WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62

Query: 65  --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
              EN+TE++I NQ+ L+ +   D+     LRNLTIV SGL+FVA  AF     L  +N 
Sbjct: 63  PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122

Query: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESS 181
           + N L SLS K  + L L EL+L GNP  CSC + W++   +E       Q L C  +  
Sbjct: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181

Query: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
              PLA++   +CG+P+  +  PN +V+ G  + L C V G  +    W +  L      
Sbjct: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238

Query: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
             S    SL +T  N++SD + K ++C AEN VG  + SV + V F P    L +    H
Sbjct: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297

Query: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
           HWCIPF+V G P P+L+W +NG++LNE+ +I T+      N T  HGCL+L+ PTH+NNG
Sbjct: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357

Query: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
           +YTL+A N +G+    I A FM  P      NP  P  +        +  GD   + +E 
Sbjct: 358 NYTLLAANPFGQASASIMAAFMDNP---FEFNPEDPIPVSFSPVDTNSTSGDPVEKKDET 414

Query: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKS 477
           P   V+   G   L+V+A + +++       ++L L K  R +KF               
Sbjct: 415 P-FGVSVAVG---LAVFACLFLST-------LLLVLNKCGRRNKF--------------- 448

Query: 478 RQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 533
             G+   +V++ +D  A  LH ++ G ++ S +EG    +     +  +IENPQYF
Sbjct: 449 --GINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYF 497


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score =  235 bits (600), Expect = 7e-62
 Identities = 160/467 (34%), Positives = 239/467 (51%), Gaps = 52/467 (11%)

Query: 72  FIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLS 131
           +I NQ+ L+ +   D+     LRNLTIV SGL+FVA  AF     L  +N + N L SLS
Sbjct: 42  YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLS 101

Query: 132 RKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESSKNIPLANLQ 190
            K  + L L EL+L GNP  CSC + W++   +E       Q L C  +     PLA++ 
Sbjct: 102 WKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG----PLAHMP 157

Query: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL 250
             +CG+P+  +  PN +V+ G  + L C V G  +    W +  L        S    SL
Sbjct: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217

Query: 251 RIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK 308
            +T  N++SD + K ++C AEN VG  + SV + V F P    L +    HHWCIPF+V 
Sbjct: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMHHWCIPFSVD 276

Query: 309 GNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNE 366
           G P P+L+W +NG++LNE+ +I T+      N T  HGCL+L+ PTH+NNG+YTL+A N 
Sbjct: 277 GQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANP 336

Query: 367 YGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKT 426
           +G+    I A FM     D+    N  D I +   T+    GD   + +E P   V+   
Sbjct: 337 FGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDETP-FGVSVAV 386

Query: 427 GREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV 486
           G   L+V+A + +++       ++L L K  R +KF                 G+   +V
Sbjct: 387 G---LAVFACLFLST-------LLLVLNKCGRRNKF-----------------GINRPAV 419

Query: 487 ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 533
           ++ +D  A  LH ++ G ++ S +EG    +     +  +IENPQYF
Sbjct: 420 LAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYF 461


>gi|94420689 neural cell adhesion molecule 1 isoform 1 [Homo
           sapiens]
          Length = 848

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 62/233 (26%), Positives = 102/233 (43%), Gaps = 24/233 (10%)

Query: 170 DTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMY 229
           D  +  C+ E+      A + +     P          +E  + +TL+C  +GDP+P++ 
Sbjct: 281 DEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340

Query: 230 W--DVGNLVSK------HMNETSHTQ-GSLRITNISSDDSGKQISCVAENLVGEDQDSVN 280
           W     N+ S+      HM   SH +  SL + +I   D+G+ I C A N +G+D  S+ 
Sbjct: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI-CTASNTIGQDSQSMY 399

Query: 281 LTVHFAPTITFLESPTSDHHW-----CIPFTVKGNPKPALQWFYNGAILNESKYICTKIH 335
           L V +AP    L+ P + + W      I   V   P   + WF +G +L  S Y   KI+
Sbjct: 400 LEVQYAPK---LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 456

Query: 336 VTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ---ISAHFMGWPGID 385
            T    Y   L++   +  + G+Y   A N  G++  +   + A     P ID
Sbjct: 457 NTPSASY---LEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSID 506



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 48/179 (26%), Positives = 82/179 (45%), Gaps = 11/179 (6%)

Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNET----SHTQGSLRITNISSDD 259
           N T   G+S+TL C   G P P M W   G  + +  ++     S     L I  +  +D
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281

Query: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS---DHHWCIPFTVKGNPKPALQ 316
             + I C+AEN  GE   +++L V   P IT++E+ T+   +    +     G+P P++ 
Sbjct: 282 EAEYI-CIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340

Query: 317 WFYNGA-ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
           W  +   I +E K +   + V +H      L L +  + + G+Y   A N  G+D + +
Sbjct: 341 WRTSTRNISSEEKTLDGHMVVRSHARV-SSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398


>gi|115529478 neural cell adhesion molecule 1 isoform 3 [Homo
           sapiens]
          Length = 761

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 62/233 (26%), Positives = 102/233 (43%), Gaps = 24/233 (10%)

Query: 170 DTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMY 229
           D  +  C+ E+      A + +     P          +E  + +TL+C  +GDP+P++ 
Sbjct: 281 DEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340

Query: 230 W--DVGNLVSK------HMNETSHTQ-GSLRITNISSDDSGKQISCVAENLVGEDQDSVN 280
           W     N+ S+      HM   SH +  SL + +I   D+G+ I C A N +G+D  S+ 
Sbjct: 341 WRTSTRNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEYI-CTASNTIGQDSQSMY 399

Query: 281 LTVHFAPTITFLESPTSDHHW-----CIPFTVKGNPKPALQWFYNGAILNESKYICTKIH 335
           L V +AP    L+ P + + W      I   V   P   + WF +G +L  S Y   KI+
Sbjct: 400 LEVQYAPK---LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIY 456

Query: 336 VTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ---ISAHFMGWPGID 385
            T    Y   L++   +  + G+Y   A N  G++  +   + A     P ID
Sbjct: 457 NTPSASY---LEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSID 506



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 48/179 (26%), Positives = 82/179 (45%), Gaps = 11/179 (6%)

Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNET----SHTQGSLRITNISSDD 259
           N T   G+S+TL C   G P P M W   G  + +  ++     S     L I  +  +D
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281

Query: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS---DHHWCIPFTVKGNPKPALQ 316
             + I C+AEN  GE   +++L V   P IT++E+ T+   +    +     G+P P++ 
Sbjct: 282 EAEYI-CIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340

Query: 317 WFYNGA-ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
           W  +   I +E K +   + V +H      L L +  + + G+Y   A N  G+D + +
Sbjct: 341 WRTSTRNISSEEKTLDGHMVVRSHARV-SSLTLKSIQYTDAGEYICTASNTIGQDSQSM 398


>gi|115529482 neural cell adhesion molecule 1 isoform 2 [Homo
           sapiens]
          Length = 858

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 34/243 (13%)

Query: 170 DTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMY 229
           D  +  C+ E+      A + +     P          +E  + +TL+C  +GDP+P++ 
Sbjct: 281 DEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340

Query: 230 W--DVGNLVSK----------------HMNETSHTQ-GSLRITNISSDDSGKQISCVAEN 270
           W     N+ S+                HM   SH +  SL + +I   D+G+ I C A N
Sbjct: 341 WRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYI-CTASN 399

Query: 271 LVGEDQDSVNLTVHFAPTITFLESPTSDHHW-----CIPFTVKGNPKPALQWFYNGAILN 325
            +G+D  S+ L V +AP    L+ P + + W      I   V   P   + WF +G +L 
Sbjct: 400 TIGQDSQSMYLEVQYAPK---LQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLP 456

Query: 326 ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ---ISAHFMGWP 382
            S Y   KI+ T    Y   L++   +  + G+Y   A N  G++  +   + A     P
Sbjct: 457 SSNYSNIKIYNTPSASY---LEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSP 513

Query: 383 GID 385
            ID
Sbjct: 514 SID 516



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 48/188 (25%), Positives = 81/188 (43%), Gaps = 19/188 (10%)

Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNET----SHTQGSLRITNISSDD 259
           N T   G+S+TL C   G P P M W   G  + +  ++     S     L I  +  +D
Sbjct: 222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKND 281

Query: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS---DHHWCIPFTVKGNPKPALQ 316
             + I C+AEN  GE   +++L V   P IT++E+ T+   +    +     G+P P++ 
Sbjct: 282 EAEYI-CIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSIT 340

Query: 317 WFYNGA-ILNESKYICTKIHVTNHTEYH---------GCLQLDNPTHMNNGDYTLIAKNE 366
           W  +   I +E K   T+       + H           L L +  + + G+Y   A N 
Sbjct: 341 WRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNT 400

Query: 367 YGKDEKQI 374
            G+D + +
Sbjct: 401 IGQDSQSM 408


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 55/209 (26%), Positives = 93/209 (44%), Gaps = 21/209 (10%)

Query: 188  NLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSH 245
            N+ +P    P       +L V+ G+ + + C+  G P+P + W  G   ++    +  S+
Sbjct: 1166 NVHVP----PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN 1221

Query: 246  TQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESP--------TS 297
              G+L I   +  D+G   +CVA N+ G D+  + L V   PT+  LE P         +
Sbjct: 1222 PDGTLSIDQATPSDAGIY-TCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVA 1280

Query: 298  DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG 357
            +     P   KG PKP ++W +NG  L   +   + +      E    L + + T  +NG
Sbjct: 1281 NQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISIL------EDGTLLVIASVTPYDNG 1334

Query: 358  DYTLIAKNEYGKDEKQISAHFMGWPGIDD 386
            +Y  +A NE G  E++ +      P I D
Sbjct: 1335 EYICVAVNEAGTTERKYNLKVHVPPVIKD 1363



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 57/188 (30%), Positives = 83/188 (44%), Gaps = 17/188 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHM-NETSHTQGSLRITNISSDDSGKQ 263
            ++V  G+ +TL C V   P P + W     L+S      T    GS++IT   + DSG  
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMY 1148

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQWF 318
            + CVA N+ G    +V L VH  P I     P            IP   +G P P + W 
Sbjct: 1149 L-CVATNIAGNVTQAVKLNVHVPPKIQ--RGPKHLKVQVGQRVDIPCNAQGTPLPVITWS 1205

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHF 378
              G+ +     +  + HV+N     G L +D  T  + G YT +A N  G DE +I+ H 
Sbjct: 1206 KGGSTM----LVDGEHHVSNPD---GTLSIDQATPSDAGIYTCVATNIAGTDETEITLHV 1258

Query: 379  MGWPGIDD 386
               P ++D
Sbjct: 1259 QEPPTVED 1266



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 55/194 (28%), Positives = 85/194 (43%), Gaps = 20/194 (10%)

Query: 188  NLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNETSHT 246
            N+Q+P    P  +       +   K ITLSC   G P P++ W   G  + + + +   +
Sbjct: 4074 NVQVP----PVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLS 4129

Query: 247  QGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLE---SPTSDHHWCI 303
             GSL+I  +   D+G   +C+A N+ G    S  LTVH  P I   E   +   +    +
Sbjct: 4130 SGSLQIAFVQPGDAG-HYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAIL 4188

Query: 304  PFTVKGNPKPALQWFYNGAILNE--SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTL 361
            P    G P PA+ W  +  +L     KY           E +G L L+N    ++G YT 
Sbjct: 4189 PCVADGIPTPAINWKKDNVLLANLLGKYT---------AEPYGELILENVVLEDSGFYTC 4239

Query: 362  IAKNEYGKDEKQIS 375
            +A N  G+D   +S
Sbjct: 4240 VANNAAGEDTHTVS 4253



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 27/233 (11%)

Query: 170 DTQDLYC--LNESSKNIPLANLQIPNCGLPSANLAAP-NLTVEEGKSITLSCSVAGDPVP 226
           D  D  C  +NE+ +      L +   G P   +  P ++++E G ++TL C V G P P
Sbjct: 766 DAGDYTCVAINEAGRATGKITLDV---GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEP 822

Query: 227 NMYW---DVGNLVSKHMNETSHTQ---GSLRITNISSDDSGKQISCVAENLVGEDQDSVN 280
            + W   D   + S+  + +S +Q   G+L I N+ + D G  I C AEN  G+ Q    
Sbjct: 823 TIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYI-CEAENQFGKIQSETT 881

Query: 281 LTVH--FAPTITFLESPTS---DHHWCIPFT-VKGNPKPALQWFYNGAILNESKYICTKI 334
           +TV    AP I    S  +        +P T + GNP P  +W  N A+L ++ YI  + 
Sbjct: 882 VTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVR- 940

Query: 335 HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDG 387
                    G L ++     + G+YT +A N  G + K  S      P I  G
Sbjct: 941 -------SDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHG 986



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 52/201 (25%), Positives = 93/201 (46%), Gaps = 18/201 (8%)

Query: 179  ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSV-AGDPVPNMYWDVGN-LV 236
            +S   + +  L  P  G+ S ++A     V EG+ +TL C++ AG+P+P   W   + ++
Sbjct: 877  QSETTVTVTGLVAPLIGI-SPSVA----NVIEGQQLTLPCTLLAGNPIPERRWIKNSAML 931

Query: 237  SKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITF---LE 293
             ++   T  + GSL I  +   D G + +CVA N+ G +  + ++ VH  PTI     + 
Sbjct: 932  LQNPYITVRSDGSLHIERVQLQDGG-EYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL 990

Query: 294  SPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTH 353
            S        +P    GNPKP++ W   G +++ S                G L + +P  
Sbjct: 991  STIEGIPVTLPCKASGNPKPSVIWSKKGELISTSS-------AKFSAGADGSLYVVSPGG 1043

Query: 354  MNNGDYTLIAKNEYGKDEKQI 374
              +G+Y   A N  G  ++++
Sbjct: 1044 EESGEYVCTATNTAGYAKRKV 1064



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 50/167 (29%), Positives = 72/167 (43%), Gaps = 15/167 (8%)

Query: 207  TVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM--NETSHTQGSLRITNISSDDSGKQI 264
            TV E     L C   G P P + W   N++  ++    T+   G L + N+  +DSG   
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFY- 4237

Query: 265  SCVAENLVGEDQDSVNLTVHFAPTITFLESPTS---DHHWCIPFTVKGNPKPALQWFYNG 321
            +CVA N  GED  +V+LTVH  PT T L    S        +     G P P L W +N 
Sbjct: 4238 TCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNN 4297

Query: 322  AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
             I+           V  H+E    L ++  +  ++G Y   A+N  G
Sbjct: 4298 NIIP-----AHFDSVNGHSE----LVIERVSKEDSGTYVCTAENSVG 4335



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 49/188 (26%), Positives = 83/188 (44%), Gaps = 21/188 (11%)

Query: 196  LPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNI 255
            LP+      ++++ +G+ + LSC   G P+P + W   N +     ++ +    L I  +
Sbjct: 4259 LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERV 4318

Query: 256  SSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPF--------TV 307
            S +DSG  + C AEN VG  + ++       P +   + P+   +W  P          V
Sbjct: 4319 SKEDSGTYV-CTAENSVGFVK-AIGFVYVKEPPVFKGDYPS---NWIEPLGGNAILNCEV 4373

Query: 308  KGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEY 367
            KG+P P +QW   G  +  S  I            +G L +    + + GDYT +A NE 
Sbjct: 4374 KGDPTPTIQWNRKGVDIEISHRI--------RQLGNGSLAIYGTVNEDAGDYTCVATNEA 4425

Query: 368  GKDEKQIS 375
            G  E+ +S
Sbjct: 4426 GVVERSMS 4433



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 54/202 (26%), Positives = 85/202 (42%), Gaps = 18/202 (8%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGS--LRITNISSDDSGK 262
            N++V E  S++L+C  +G P+P++ W          N      G   LR+   + +D+G 
Sbjct: 2395 NISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAG- 2453

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTI---TFLESPTSDHHWCIPFT--VKGNPKPALQW 317
            Q +CV  N  GE++    L+V   P I     LE         +  T  V GNP P + W
Sbjct: 2454 QYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITW 2513

Query: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
              +G  L E +      H+ +   +   LQ+ N    + G YT +A +  G   +  S +
Sbjct: 2514 HKDGQPLQEDE----AHHIISGGRF---LQITNVQVPHTGRYTCLASSPAGHKSRSFSLN 2566

Query: 378  FMGWP---GIDDGANPNYPDVI 396
                P   G+    NP    VI
Sbjct: 2567 VFVSPTIAGVGSDGNPEDVTVI 2588



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 49/211 (23%), Positives = 87/211 (41%), Gaps = 14/211 (6%)

Query: 170 DTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMY 229
           D  + +C+  S      A++ +     P   +   N +   G  +++ CS  G P P + 
Sbjct: 585 DAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIA 644

Query: 230 WDVGN--LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
           W V +  +V  H    + + G+L I N +  D+G    C+A N  G D+ +  L    AP
Sbjct: 645 WTVNDMFIVGSHRYRMT-SDGTLFIKNAAPKDAG-IYGCLASNSAGTDKQNSTLRYIEAP 702

Query: 288 TITFLESP---TSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHG 344
            +  ++S           +     G P P ++WF     L  S ++             G
Sbjct: 703 KLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLII-------DPLLG 755

Query: 345 CLQLDNPTHMNNGDYTLIAKNEYGKDEKQIS 375
            L++     ++ GDYT +A NE G+   +I+
Sbjct: 756 LLKIQETQDLDAGDYTCVAINEAGRATGKIT 786



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 51/201 (25%), Positives = 79/201 (39%), Gaps = 23/201 (11%)

Query: 197  PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITN 254
            P+      +L +   KS  L C   G P P + W  D   L   H   +    G L I +
Sbjct: 3713 PNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQS 3772

Query: 255  ISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKG 309
                D+G+ + C+A N  G D+  ++L VH  P+I     PT+     +    +     G
Sbjct: 3773 AHVTDTGRYL-CMATNAAGTDRRRIDLQVHVPPSIA--PGPTNMTVIVNVQTTLACEATG 3829

Query: 310  NPKPALQWFYNGAILNESKYICTKIHVTNHTEYH----GCLQLDNPTHMNNGDYTLIAKN 365
             PKP++ W  NG +LN  +         N   Y     G L + +P+  +   Y     N
Sbjct: 3830 IPKPSINWRKNGHLLNVDQ---------NQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880

Query: 366  EYGKDEKQISAHFMGWPGIDD 386
              G D++ +       P I D
Sbjct: 3881 GAGDDKRTVDLTVQVPPSIAD 3901



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 53/193 (27%), Positives = 84/193 (43%), Gaps = 25/193 (12%)

Query: 197  PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSH---TQGSLRI 252
            PS      N+TV      TL+C   G P P++ W   G+L++   N+ S+   + GSL I
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVI 3863

Query: 253  TNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESP-----TSDHHWCIPFTV 307
             + S DD+     C   N  G+D+ +V+LTV   P+I   + P     T      I  T 
Sbjct: 3864 ISPSVDDTA-TYECTVTNGAGDDKRTVDLTVQVPPSIA--DEPTDFLVTKHAPAVITCTA 3920

Query: 308  KGNPKPALQWFYNGAIL---NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAK 364
             G P P++ W  NG  L    +   I +           G +++      + G YT +A+
Sbjct: 3921 SGVPFPSIHWTKNGIRLLPRGDGYRILSS----------GAIEILATQLNHAGRYTCVAR 3970

Query: 365  NEYGKDEKQISAH 377
            N  G   + ++ H
Sbjct: 3971 NAAGSAHRHVTLH 3983



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 53/183 (28%), Positives = 79/183 (43%), Gaps = 18/183 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDV--GNLVSKHMNETSHTQGSLRI-TNISSDDSGK 262
            LTV EG  I+L C  +G P PN+ W      +++  M       G  ++  +I+      
Sbjct: 2206 LTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAA 2265

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLES------PTSDHHWCIPFTVKGNPKPALQ 316
              SCVA N+ G  +   NL V+  PTIT   S       T      +   V+G P P + 
Sbjct: 2266 LYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVT 2325

Query: 317  WFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ--I 374
            W  +G  L ++K +  +I    H      LQL N    + G Y  +A N  G  +K+  +
Sbjct: 2326 WMKDGHPLIKAKGV--EILDEGH-----ILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDL 2378

Query: 375  SAH 377
            S H
Sbjct: 2379 SVH 2381



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 51/180 (28%), Positives = 79/180 (43%), Gaps = 28/180 (15%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGK 262
            ++ V+E +S+TL+C V G+PVP + W  D   L     +        L+ITN+    +G+
Sbjct: 2488 DVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGR 2547

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTI-------------TFLESPTSDHHWCIPFTVKG 309
              +C+A +  G    S +L V  +PTI               L SPTS     +      
Sbjct: 2548 -YTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS-----LVCEAYS 2601

Query: 310  NPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
             P   + WF +G  L  ++ I  +I     T     LQ+ N    N G Y+ +A NE G+
Sbjct: 2602 YPPATITWFKDGTPLESNRNI--RILPGGRT-----LQILNAQEDNAGRYSCVATNEAGE 2654



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 49/190 (25%), Positives = 80/190 (42%), Gaps = 17/190 (8%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQG--SLRITNISSDDSGK 262
            NLTV     I+L+C V+G P P++ W       K    T    G  +L+I      D G 
Sbjct: 2973 NLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGG- 3031

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSD-----HHWCIPFTVKGN--PKPAL 315
            + +C+A N  GE +   +LTV+  P+I   +S +           +    + N  P P +
Sbjct: 3032 EYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVI 3091

Query: 316  QWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQIS 375
             W+ NG ++ ES    T + +    +    L +      + G Y   A N  G+D+K   
Sbjct: 3092 TWYKNGRMITES----THVEILADGQ---MLHIKKAEVSDTGQYVCRAINVAGRDDKNFH 3144

Query: 376  AHFMGWPGID 385
             +    P I+
Sbjct: 3145 LNVYVPPSIE 3154



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 46/175 (26%), Positives = 76/175 (43%), Gaps = 16/175 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263
            + V  GKSI+L C V G P P + W  D   L+     E       L++ NI   D+G+ 
Sbjct: 2302 IIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRY 2361

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLE------SPTSDHHWCIPFTVKGNPKPALQW 317
            + CVA N+ G      +L+VH  P+I          S    +   +     G P P++ W
Sbjct: 2362 V-CVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITW 2420

Query: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
            F +G  ++    +   + + +       L+L   T  + G YT + +N  G++ K
Sbjct: 2421 FKDGWPVS----LSNSVRILSGGR---MLRLMQTTMEDAGQYTCVVRNAAGEERK 2468



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 55/200 (27%), Positives = 81/200 (40%), Gaps = 19/200 (9%)

Query: 196  LPSANLAAPN-LTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRI 252
            +  AN   P  +TV   KS  + C  +G P P   W  D   L+    ++       L+I
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQI 2930

Query: 253  TNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESP----TSDHHWCIPFTVK 308
             N    D G+ + CVAEN  G  +   NL VH  P++   +S       ++   +   V 
Sbjct: 2931 LNTQITDIGRYV-CVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVS 2989

Query: 309  GNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHG--CLQLDNPTHMNNGDYTLIAKNE 366
            G P P L W  N   +  +         TN     G   LQ+      + G+YT IA N+
Sbjct: 2990 GFPPPDLSWLKNEQPIKLN---------TNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQ 3040

Query: 367  YGKDEKQISAHFMGWPGIDD 386
             G+ +K+ S      P I D
Sbjct: 3041 AGESKKKFSLTVYVPPSIKD 3060



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 46/173 (26%), Positives = 73/173 (42%), Gaps = 12/173 (6%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQGS-LRITNISSDDSGKQ 263
            + V EG S++L C     P P + W   G ++++  +      G  L I      D+G+ 
Sbjct: 3069 VNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQY 3128

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK----GNPKPALQWFY 319
            + C A N+ G D  + +L V+  P+I   E          P T+     G P P + W  
Sbjct: 3129 V-CRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLK 3187

Query: 320  NGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
            N   +  S  +  +I           LQ+    H ++G+YT IA N  GK +K
Sbjct: 3188 NHKRIENSDSLEVRILSGGSK-----LQIARSQHSDSGNYTCIASNMEGKAQK 3235



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 66/284 (23%), Positives = 110/284 (38%), Gaps = 53/284 (18%)

Query: 146  VGNPFTCSCD--------IMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCG-- 195
            + NP T +CD        I W+K  +  ++S D+ ++  L+  SK + +A  Q  + G  
Sbjct: 3165 ISNPVTLTCDATGIPPPTIAWLKNHKRIENS-DSLEVRILSGGSK-LQIARSQHSDSGNY 3222

Query: 196  --------------------LPSANLAAP---NLTVEEGKSITLSCSVAGDPVPNMYW-D 231
                                +P +   A    +++V  G+++ L C+  G P P + W  
Sbjct: 3223 TCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLK 3282

Query: 232  VGNLVSKHMNE---TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPT 288
             G  ++    E    S    +L I    + D+GK  +CVA N  GE+    NL V+  PT
Sbjct: 3283 DGKPIASGETERIRVSANGSTLNIYGALTSDTGKY-TCVATNPAGEEDRIFNLNVYVTPT 3341

Query: 289  ITFLESPTS------DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEY 342
            I   +          D    I     G P P + W  NG  L  S +I  ++        
Sbjct: 3342 IRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHI--RLLAAGQV-- 3397

Query: 343  HGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDD 386
               +++      +   YT +A N  G D K  +      P +D+
Sbjct: 3398 ---IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDN 3438



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 66/282 (23%), Positives = 104/282 (36%), Gaps = 49/282 (17%)

Query: 140  LSELILVGNPFTCSCD--------IMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQI 191
            L+E +LV NP    C         I W K  +    S     L       + I + + QI
Sbjct: 1928 LNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFL----NRGQIIDIESAQI 1983

Query: 192  PNCGL-----------------------PSANLAAPNLTVEEGKSITLSCSVAGDPVPNM 228
             + G+                       PS + +   + V     + L C   G P P++
Sbjct: 1984 SDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSL 2043

Query: 229  YW-DVGNLVSKHMNETSHTQGS--LRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
             W   G+ VS   N      G   L +T+    D+G+  +CVA N  GE Q  ++L V+ 
Sbjct: 2044 TWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRY-TCVAVNAAGEKQRDIDLRVYV 2102

Query: 286  APTITFLESPTSD-HHWCIPFTVKGN--PKPALQWFYNGAILNESKYICTKIHVTNHTEY 342
             P I   E   S      +    + +  P P L W  +G  L +   +       + +E 
Sbjct: 2103 PPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGL-------SISEN 2155

Query: 343  HGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGI 384
               L++++    + G YT  A N  GK EK  + +    P I
Sbjct: 2156 RSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNI 2197



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 56/245 (22%), Positives = 95/245 (38%), Gaps = 16/245 (6%)

Query: 161 TLQEAKSSPDTQDLY-CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCS 219
           TL    ++P    +Y CL  +S      N  +     P   +    L V  G    + C 
Sbjct: 665 TLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECK 724

Query: 220 VAGDPVPNMYWDVGNLVSKHMNET--SHTQGSLRITNISSDDSGKQISCVAENLVGEDQD 277
            +G P P + W  G+L  +           G L+I      D+G   +CVA N  G    
Sbjct: 725 TSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAG-DYTCVAINEAGRATG 783

Query: 278 SVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICT 332
            + L V   P   F++ P         +  +P  V+G P+P ++W      L+       
Sbjct: 784 KITLDVGSPPV--FIQEPADVSMEIGSNVTLPCYVQGYPEPTIKW----RRLDNMPIFSR 837

Query: 333 KIHVTNHTEYH-GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPN 391
              V++ ++   G L + N    + G Y   A+N++GK + + +    G      G +P+
Sbjct: 838 PFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPS 897

Query: 392 YPDVI 396
             +VI
Sbjct: 898 VANVI 902



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 49/202 (24%), Positives = 86/202 (42%), Gaps = 18/202 (8%)

Query: 179  ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLV 236
            E SK+  L  L+ P+    + +     ++V     + L+C  +G P P M W  D   L 
Sbjct: 3514 EVSKHFILKVLEPPHI---NGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLP 3570

Query: 237  SKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESP- 295
                 +T      LRI+    +D+G+  +C+A +  G+D     + VH  P I   + P 
Sbjct: 3571 QTDQVQTLGGGEVLRISTAQVEDTGRY-TCLASSPAGDDDKEYLVRVHVPPNIAGTDEPR 3629

Query: 296  --TSDHHWCIPFTVKGN--PKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNP 351
              T   +  +    K +  P P + W  NG  L  +     ++ + +   Y   LQ++N 
Sbjct: 3630 DITVLRNRQVTLECKSDAVPPPVITWLRNGERLQAT----PRVRILSGGRY---LQINNA 3682

Query: 352  THMNNGDYTLIAKNEYGKDEKQ 373
               +  +YT +A N  GK  ++
Sbjct: 3683 DLGDTANYTCVASNIAGKTTRE 3704



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 48/190 (25%), Positives = 73/190 (38%), Gaps = 14/190 (7%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN--ETSHTQGSLRITNISSDDSGK 262
            N++V   +   L C V G P P + W   N+     +  +T +    L++   + +D+G+
Sbjct: 1369 NVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGR 1428

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQW 317
              SC A N+ G  Q   N+ V   PTI     P       +    +   VKG P P + W
Sbjct: 1429 Y-SCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHW 1487

Query: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
            F +G  L         + + +  +    L L N    + G Y     N  GK  K I   
Sbjct: 1488 FKDGKPLFLGD---PNVELLDRGQV---LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLT 1541

Query: 378  FMGWPGIDDG 387
                P I  G
Sbjct: 1542 IYIPPSIKGG 1551



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 51/179 (28%), Positives = 70/179 (39%), Gaps = 29/179 (16%)

Query: 213  SITLSCSVAGDPVPNMYWDVGNL---VSKHMNETSHTQGSLRITNISSDDSGKQISCVAE 269
            SI + C   G P P + W    L   +S H+   +  Q  +RI      D     +CVA 
Sbjct: 3359 SINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQ-VIRIVRAQVSDVAVY-TCVAS 3416

Query: 270  NLVGEDQDSVNLTVHFAPT---------ITFLESPTSDHHWCIPFTVKGNPKPALQWFYN 320
            N  G D    NL V   P          IT L+  +S    CI     G P P++ W  +
Sbjct: 3417 NRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKG-SSTSMACI---TDGTPAPSMAWLRD 3472

Query: 321  GAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFM 379
            G  L    ++    H          LQL      ++G YT IA NE G    ++S HF+
Sbjct: 3473 GQPLGLDAHLTVSTHGM-------VLQLLKAETEDSGKYTCIASNEAG----EVSKHFI 3520



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 14/135 (10%)

Query: 196  LPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNETSH-TQGSLRIT 253
            LP+       L+  EG  +TL C  +G+P P++ W   G L+S    + S    GSL + 
Sbjct: 980  LPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVV 1039

Query: 254  NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLE-----------SPTSDHHWC 302
            +   ++SG+ + C A N  G  +  V LTV+  P +   +           S  +     
Sbjct: 1040 SPGGEESGEYV-CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVT 1098

Query: 303  IPFTVKGNPKPALQW 317
            +P  VK  P P + W
Sbjct: 1099 LPCEVKSLPPPIITW 1113



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 63/287 (21%), Positives = 107/287 (37%), Gaps = 52/287 (18%)

Query: 143  LILVGNPFTCSCD--------IMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNC 194
            +++V N     C         IMW+K  Q      D +D + +  + + + +A  Q+ N 
Sbjct: 1745 IVMVNNLLELDCHVTGSPPPTIMWLKDGQLI----DERDGFKILLNGRKLVIAQAQVSNT 1800

Query: 195  GL---PSANLAAPNL---------------------TVEEGKSITLSCSVAGDPVPNMYW 230
            GL    +AN A  +                       V + K + L C   G P P++ W
Sbjct: 1801 GLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW 1860

Query: 231  DVGNLVSKHMNETSHTQGSLRITNISS---DDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
               +            Q S R+  I+    +D+G+  +CVA N  GE Q  + L VH  P
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRY-TCVATNAAGETQQHIQLHVHEPP 1919

Query: 288  TI-----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEY 342
            ++        E+    +   +     GNP P + W+ +  +L+ S    T +   N  + 
Sbjct: 1920 SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS----TSMTFLNRGQ- 1974

Query: 343  HGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGAN 389
               + +++    + G Y  +A N  G  E   S      P I    N
Sbjct: 1975 --IIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNN 2019



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 55/203 (27%), Positives = 81/203 (39%), Gaps = 19/203 (9%)

Query: 205  NLTVEE---GKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLR-ITNISSD 258
            N T +E    + I   C   G P P + W  +   L  +    +    G+L  I +++  
Sbjct: 1272 NTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPY 1331

Query: 259  DSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFT-----VKGNPKP 313
            D+G+ I CVA N  G  +   NL VH  P I   E  T+        T     V+G P P
Sbjct: 1332 DNGEYI-CVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSP 1390

Query: 314  ALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ 373
             + W+ +   + ES  I T   V N       L+L   T  + G Y+  A N  G  +K 
Sbjct: 1391 IIMWYKDNVQVTESSTIQT---VNNGK----ILKLFRATPEDAGRYSCKAINIAGTSQKY 1443

Query: 374  ISAHFMGWPGIDDGANPNYPDVI 396
             +   +  P I     PN   V+
Sbjct: 1444 FNIDVLVPPTIIGTNFPNEVSVV 1466



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 45/181 (24%), Positives = 76/181 (41%), Gaps = 15/181 (8%)

Query: 200  NLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQGS-LRITNISS 257
            ++    +TV +G S +++C   G P P+M W   G  +    + T  T G  L++    +
Sbjct: 3439 SMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAET 3498

Query: 258  DDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLE-----SPTSDHHWCIPFTVKGNPK 312
            +DSGK  +C+A N  GE      L V   P I   E     S   ++   +     G P 
Sbjct: 3499 EDSGK-YTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPA 3557

Query: 313  PALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
            P + W  +G  L ++  + T             L++      + G YT +A +  G D+K
Sbjct: 3558 PKMTWMKDGRPLPQTDQVQT-------LGGGEVLRISTAQVEDTGRYTCLASSPAGDDDK 3610

Query: 373  Q 373
            +
Sbjct: 3611 E 3611



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 47/190 (24%), Positives = 77/190 (40%), Gaps = 22/190 (11%)

Query: 200  NLAAP-NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSD 258
            NLA P N  V    S+TL C  AG+P P + W    +  K  +      G  ++  +S+ 
Sbjct: 1644 NLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQ 1703

Query: 259  DSGK-QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFT--------VKG 309
            +  + Q  CVA ++ GE +    + V   P I   E      ++ +           V G
Sbjct: 1704 EIDRGQYICVATSVAGEKEIKYEVDVLVPPAI---EGGDETSYFIVMVNNLLELDCHVTG 1760

Query: 310  NPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG- 368
            +P P + W  +G +++E      KI +         L +      N G Y  +A N  G 
Sbjct: 1761 SPPPTIMWLKDGQLIDERDGF--KILLNGRK-----LVIAQAQVSNTGLYRCMAANTAGD 1813

Query: 369  -KDEKQISAH 377
             K E +++ H
Sbjct: 1814 HKKEFEVTVH 1823



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 44/186 (23%), Positives = 73/186 (39%), Gaps = 19/186 (10%)

Query: 189  LQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSHT 246
            +Q+P    PS      +  V +     ++C+ +G P P+++W      L+ +       +
Sbjct: 3893 VQVP----PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILS 3948

Query: 247  QGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS---DHHWCI 303
             G++ I     + +G+  +CVA N  G     V L VH  P I    S      ++   +
Sbjct: 3949 SGAIEILATQLNHAGRY-TCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILL 4007

Query: 304  PFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLI 362
            P    G P P + W   G  +N S          NH     G LQ+      + G Y  +
Sbjct: 4008 PCEATGTPSPFITWQKEGINVNTSG--------RNHAVLPSGGLQISRAVREDAGTYMCV 4059

Query: 363  AKNEYG 368
            A+N  G
Sbjct: 4060 AQNPAG 4065



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 46/214 (21%), Positives = 83/214 (38%), Gaps = 28/214 (13%)

Query: 201  LAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSK---HMNETSHTQGSLRITNISS 257
            L+   + ++   ++TL C     P  ++ W       K   H+N  ++   +L+I     
Sbjct: 2679 LSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH-TLQIKEAQI 2737

Query: 258  DDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFL---------------ESPTSDHHWC 302
             D+G+  +CVA N+ GED+   ++ +   P+   L               +    ++   
Sbjct: 2738 SDTGRY-TCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPIS 2796

Query: 303  IPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLI 362
            +       P P L W+ +G  L  S  +               LQ+      + G YT +
Sbjct: 2797 LYCETNAAPPPTLTWYKDGHPLTSSDKVLI-------LPGGRVLQIPRAKVEDAGRYTCV 2849

Query: 363  AKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVI 396
            A NE G+D  Q     +  P I  GAN + P+ +
Sbjct: 2850 AVNEAGEDSLQYDVRVL-VPPIIKGANSDLPEEV 2882



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 47/194 (24%), Positives = 72/194 (37%), Gaps = 25/194 (12%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGS--LRITNISSDDSGK 262
            ++TV   + +TL C     P P + W       +         G   L+I N    D+  
Sbjct: 3630 DITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTAN 3689

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQW 317
              +CVA N+ G+      LTV+  P I     P S     +    +    +G P P + W
Sbjct: 3690 Y-TCVASNIAGKTTREFILTVNVPPNIK--GGPQSLVILLNKSTVLECIAEGVPTPRITW 3746

Query: 318  FYNGAILNESKYICTKIHVTNHTEY----HGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ 373
              +GA+L             NH  Y    +G L + +    + G Y  +A N  G D ++
Sbjct: 3747 RKDGAVL-----------AGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRR 3795

Query: 374  ISAHFMGWPGIDDG 387
            I       P I  G
Sbjct: 3796 IDLQVHVPPSIAPG 3809



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 35/128 (27%), Positives = 57/128 (44%), Gaps = 12/128 (9%)

Query: 204  PN-LTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGS-LRITNISSDD 259
            PN ++V   + + L C V G P P+++W  D   L     N     +G  L + N   +D
Sbjct: 1460 PNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRND 1519

Query: 260  SGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK------GNPKP 313
             G+   C   N  G+    + LT++  P+I    + T+D    I   +K      G P P
Sbjct: 1520 KGR-YQCTVSNAAGKQAKDIKLTIYIPPSIKG-GNVTTDISVLINSLIKLECETRGLPMP 1577

Query: 314  ALQWFYNG 321
            A+ W+ +G
Sbjct: 1578 AITWYKDG 1585



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 42/164 (25%), Positives = 60/164 (36%), Gaps = 22/164 (13%)

Query: 214  ITLSCSVAGDPVPNMYWDVG--NLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENL 271
            I L C   G P P + W     N+ +   N      G L+I+    +D+G  + CVA+N 
Sbjct: 4005 ILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYM-CVAQNP 4063

Query: 272  VGEDQDSVNLTVHFAPTITFLESP-------TSDHHWCIPFTVKGNPKPALQWFYNGAIL 324
             G     + L V   P I    SP         D    +     G P P + W  +G  +
Sbjct: 4064 AGTALGKIKLNVQVPPVI----SPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAI 4119

Query: 325  NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
             ES        +       G LQ+      + G YT +A N  G
Sbjct: 4120 VES--------IRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 42/169 (24%), Positives = 64/169 (37%), Gaps = 29/169 (17%)

Query: 249  SLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLE------SPTS----- 297
            +L+I N   D++G+  SCVA N  GE      + V+  P I   +      SP       
Sbjct: 2630 TLQILNAQEDNAGRY-SCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKV 2688

Query: 298  DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNG 357
            ++   +       P  +L W+ +G  L    ++   I    HT     LQ+      + G
Sbjct: 2689 NNTLTLECEAYAIPSASLSWYKDGQPLKSDDHV--NIAANGHT-----LQIKEAQISDTG 2741

Query: 358  DYTLIAKNEYGKDEKQISAHFMGWPG----------IDDGANPNYPDVI 396
             YT +A N  G+DE     +    P           +D G N    DVI
Sbjct: 2742 RYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVI 2790



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 25/105 (23%), Positives = 43/105 (40%), Gaps = 2/105 (1%)

Query: 170  DTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMY 229
            D  D  C+  +   +   ++ +     P   L      +  G  I L+C   G+P P + 
Sbjct: 4413 DAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTIT 4472

Query: 230  WD-VGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVG 273
            W   G+ +S        +  SL I +   +D+  +  CVA NL+G
Sbjct: 4473 WSRQGHSISWDDRVNVLSNNSLYIADAQKEDT-SEFECVARNLMG 4516



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 42/187 (22%), Positives = 71/187 (37%), Gaps = 16/187 (8%)

Query: 214  ITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENL 271
            I L C   G P+P + W  D   ++S            L I      DS    +C   N+
Sbjct: 1565 IKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATY-TCHVANV 1623

Query: 272  VGEDQDSVNLTVHFAPTITF-LESPTSD-----HHWCIPFTVKGNPKPALQWFYNGAILN 325
             G  + S ++ V+  P I   L +P +      H   +     GNP P L W  +G  + 
Sbjct: 1624 AGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVK 1683

Query: 326  ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGID 385
             +  I  +I           L++ +   ++ G Y  +A +  G+ E +     +  P I+
Sbjct: 1684 ANDNI--RIEAGGKK-----LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIE 1736

Query: 386  DGANPNY 392
             G   +Y
Sbjct: 1737 GGDETSY 1743



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 44/192 (22%), Positives = 67/192 (34%), Gaps = 17/192 (8%)

Query: 214  ITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENL 271
            I+L C     P P + W  D   L S            L+I     +D+G+  +CVA N 
Sbjct: 2795 ISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRY-TCVAVNE 2853

Query: 272  VGEDQDSVNLTVHFAPTITFLESPTSDH-------HWCIPFTVKGNPKPALQWFYNGAIL 324
             GED    ++ V   P I    S   +           I     G+P P   W  +G  L
Sbjct: 2854 AGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL 2913

Query: 325  NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGI 384
             E  +                LQ+ N    + G Y  +A+N  G  +K  + +    P +
Sbjct: 2914 LEDDH-------HKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSV 2966

Query: 385  DDGANPNYPDVI 396
                + N   V+
Sbjct: 2967 IGPKSENLTVVV 2978


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 92/414 (22%), Positives = 152/414 (36%), Gaps = 77/414 (18%)

Query: 18  FCW----LVVGFWRAAFACPTSCKCSASRIWCS----DPSPGI--------VAFPRLE-- 59
           FCW    L+ G+      CP+ C C  S + C     D  P +        + F R+   
Sbjct: 6   FCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREI 65

Query: 60  PNSVDPE--NITEIFIAN-----------------------QKRLEIINEDDVEAYVGLR 94
           P S   +  N+  + + N                       +  +  +++   +  + L 
Sbjct: 66  PGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLE 125

Query: 95  NLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLD-LSELILVGNPFTCS 153
           +L I  + L+ +  + F     L+ +    NKL+ +    F +LD L  L L  N   C 
Sbjct: 126 HLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCD 185

Query: 154 CDIMWIKTL-----QEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTV 208
           CD+MW+  L     Q   +       Y      + +    ++  NC  P       ++ V
Sbjct: 186 CDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEV 245

Query: 209 EEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS---HTQGSLRITNISSDDSGKQIS 265
             G ++  +C   G+P P + W   N      ++T       G+L I N    D G    
Sbjct: 246 PSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQG-VYQ 304

Query: 266 CVAENLVGEDQ-DSVNLTVHFAPT-ITFLESP--------TSDHHWCIPFTVKGNPKPAL 315
           C+A N  GE +  S  L     P   +F+  P        TS    C+     G+P P +
Sbjct: 305 CMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECM---ATGHPHPLI 361

Query: 316 QWFY-NGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
            W   NG  L+ S+++ T             L L N T  ++G +T  A N +G
Sbjct: 362 TWTRDNGLELDGSRHVATS----------SGLYLQNITQRDHGRFTCHANNSHG 405



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 45/178 (25%), Positives = 71/178 (39%), Gaps = 15/178 (8%)

Query: 197 PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWD-VGNLVSKHMNETSHTQGSLRITNI 255
           P   +   +  V E  ++   C   G+P P + W   G  +      T  + G+LRI   
Sbjct: 419 PQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRA 478

Query: 256 SSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH-----HWCIPFTVKGN 310
           +  D G Q  C A + +G  + SV LTV       F + P         +  I    +G 
Sbjct: 479 AQHDQG-QYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGE 537

Query: 311 PKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
           P+P + W   G  + ES     K HV +     G L + +    + G Y  +A+N +G
Sbjct: 538 PQPIITWNKEGVQITESG----KFHVDDE----GTLTIYDAGFPDQGRYECVARNSFG 587



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 45/177 (25%), Positives = 66/177 (37%), Gaps = 16/177 (9%)

Query: 197 PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNIS 256
           PS  +   +  V  G S TL C   G P P + W   N +    +    T   L + NI+
Sbjct: 330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNIT 389

Query: 257 SDDSGKQISCVAENLVGEDQDSVNLTVHFAP--TITFLESPTSDHH---WCIPFTVKGNP 311
             D G+  +C A N  G  Q + N+ V   P  T+T  +    + H   W       GNP
Sbjct: 390 QRDHGR-FTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLC--EADGNP 446

Query: 312 KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
            P + W   G  L         +   +     G L++D     + G Y   A +  G
Sbjct: 447 PPVIVWTKTGGQL--------PVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLG 495



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 2/78 (2%)

Query: 207 TVEEGKSITLSCSVAGDPVPNMYWD-VGNLVSKHMNETSHTQGSLRITNISSDDSGKQIS 265
           +VE GK+I +SC   G+P P + W+  G  +++        +G+L I +    D G+   
Sbjct: 521 SVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGR-YE 579

Query: 266 CVAENLVGEDQDSVNLTV 283
           CVA N  G    ++ LTV
Sbjct: 580 CVARNSFGLAVTNMFLTV 597


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 60/233 (25%), Positives = 101/233 (43%), Gaps = 20/233 (8%)

Query: 67  NITEIFIANQKRLEIINEDDVEAYVGLRNLTIVD----SGLKFVAHKAFLKNSNLQHINF 122
           ++ E+ + N + L  I   D  A V L  LT +D      L F+  +AF     ++ +  
Sbjct: 286 HLKELGLNNMEELVSI---DKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLML 342

Query: 123 TRNKLTSLSRKHFRHL-DLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESS 181
             N L++L ++    L +L E+ L GNP  C C I W           + Q   C     
Sbjct: 343 NNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPD 402

Query: 182 ------KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVG-- 233
                 + +P   +      L S     P+L V  G+S+ L C    +P P +YW     
Sbjct: 403 LQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAG 462

Query: 234 -NLVSKHMNE--TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV 283
             L   H       + +G+L +  ++++++G   +CVA+NLVG D  +V++ V
Sbjct: 463 LRLTPAHAGRRYRVYPEGTLELRRVTAEEAG-LYTCVAQNLVGADTKTVSVVV 514


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 60/233 (25%), Positives = 101/233 (43%), Gaps = 20/233 (8%)

Query: 67  NITEIFIANQKRLEIINEDDVEAYVGLRNLTIVD----SGLKFVAHKAFLKNSNLQHINF 122
           ++ E+ + N + L  I   D  A V L  LT +D      L F+  +AF     ++ +  
Sbjct: 286 HLKELGLNNMEELVSI---DKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLML 342

Query: 123 TRNKLTSLSRKHFRHL-DLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESS 181
             N L++L ++    L +L E+ L GNP  C C I W           + Q   C     
Sbjct: 343 NNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPD 402

Query: 182 ------KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVG-- 233
                 + +P   +      L S     P+L V  G+S+ L C    +P P +YW     
Sbjct: 403 LQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAG 462

Query: 234 -NLVSKHMNE--TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV 283
             L   H       + +G+L +  ++++++G   +CVA+NLVG D  +V++ V
Sbjct: 463 LRLTPAHAGRRYRVYPEGTLELRRVTAEEAG-LYTCVAQNLVGADTKTVSVVV 514


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 61/229 (26%), Positives = 96/229 (41%), Gaps = 32/229 (13%)

Query: 86  DVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLD-LSELI 144
           D+     L+ L +  + L F+   AF     L+ +    N+L +L+   F  L  LS L 
Sbjct: 117 DLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQ 176

Query: 145 LVGNPFTCSCDIMWIKT--LQEAKSSPDTQDLYCLN-ESSKNIPLANLQIPNCGLPSANL 201
           +  NPF C+C I+W+KT  L  A S P+  ++ C +    K  PL+ L    C  PS  L
Sbjct: 177 INENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQL 236

Query: 202 ----AAPNLTVEEGKSITLSCSVAGDPVPNMYW--------------DVGN--------- 234
               +     +  G  + L C V G P P ++W              +VG          
Sbjct: 237 SYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTP 296

Query: 235 LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV 283
           + S      +   GSL I +    + G   SC+A N +G  + SV++ +
Sbjct: 297 VASSQPRFQAFANGSLLIPDFGKLEEG-TYSCLATNELGSAESSVDVAL 344


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 61/229 (26%), Positives = 96/229 (41%), Gaps = 32/229 (13%)

Query: 86  DVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLD-LSELI 144
           D+     L+ L +  + L F+   AF     L+ +    N+L +L+   F  L  LS L 
Sbjct: 117 DLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQ 176

Query: 145 LVGNPFTCSCDIMWIKT--LQEAKSSPDTQDLYCLN-ESSKNIPLANLQIPNCGLPSANL 201
           +  NPF C+C I+W+KT  L  A S P+  ++ C +    K  PL+ L    C  PS  L
Sbjct: 177 INENPFDCTCGIVWLKTWALTTAVSIPEQDNIACTSPHVLKGTPLSRLPPLPCSAPSVQL 236

Query: 202 ----AAPNLTVEEGKSITLSCSVAGDPVPNMYW--------------DVGN--------- 234
               +     +  G  + L C V G P P ++W              +VG          
Sbjct: 237 SYQPSQDGAELRPGFVLALHCDVDGQPAPQLHWHIQIPSGIVEITSPNVGTDGRALPGTP 296

Query: 235 LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV 283
           + S      +   GSL I +    + G   SC+A N +G  + SV++ +
Sbjct: 297 VASSQPRFQAFANGSLLIPDFGKLEEG-TYSCLATNELGSAESSVDVAL 344


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 64/231 (27%), Positives = 94/231 (40%), Gaps = 22/231 (9%)

Query: 162 LQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVA 221
           L+ +K+   T +  C   S      A  QI     P   + APN+TV  G++  LSC V 
Sbjct: 367 LRASKAEEGTYE--CTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 424

Query: 222 GDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSV 279
           G+   N+ W  D   L +           SL I+ I   D G+   CVA N  G  + SV
Sbjct: 425 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGR-YQCVASNANGVTRASV 483

Query: 280 NLTVHFAPTITFLESPTSDHHWCIPFTVK------GNPKPALQWFYNGAILNESKYICTK 333
            L V  AP ++     TS  H+     VK      G P P + W      L E   I   
Sbjct: 484 WLLVREAPQVSI---HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI--- 537

Query: 334 IHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGI 384
                H +  G L +      + G+Y+  A NE G D++ ++ ++   P +
Sbjct: 538 -----HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV 583



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 46/206 (22%), Positives = 87/206 (42%), Gaps = 21/206 (10%)

Query: 176 CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL 235
           C+  ++  +  A++ +     P  ++   +    +G  + +SCS +G P P++ W   + 
Sbjct: 470 CVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW---SR 526

Query: 236 VSKHMNETSH----TQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITF 291
            S+ + E S      QG+L I  ++ +D+G   SC A N VG DQ++V L     P+++ 
Sbjct: 527 ESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY-SCQATNEVGTDQETVTLYYTDPPSVSA 585

Query: 292 LES---PTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQL 348
           + +           +     G P P + W+  G           ++ +       G L++
Sbjct: 586 VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG----------LEMILAPEGSSSGKLRI 635

Query: 349 DNPTHMNNGDYTLIAKNEYGKDEKQI 374
                 + G YT  A NE G    +I
Sbjct: 636 PAAQERDAGTYTCRAVNELGDASAEI 661



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/207 (23%), Positives = 74/207 (35%), Gaps = 33/207 (15%)

Query: 187 ANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGN--------LVSK 238
           A +Q+     P       ++TVE G+S  L+C   G P P + W  G+           +
Sbjct: 659 AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR 718

Query: 239 HMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV---------HFAPTI 289
                    G L   +++ +D    + C A N+ G+ Q    L V           APT+
Sbjct: 719 GSRSRQPDSGVLFFESVAPEDQAPYV-CEARNVFGKVQAEARLIVTGHAPPQIASSAPTV 777

Query: 290 TFLE-SPTSDHHWCIP-FTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQ 347
             LE  P S     +P   + G P P   W  +G  L             +     G L 
Sbjct: 778 RVLEGQPVS-----LPCIVLAGRPLPERHWLKDGRPLPPGS--------RHSIRADGSLH 824

Query: 348 LDNPTHMNNGDYTLIAKNEYGKDEKQI 374
           LD     + G Y+ +A N  G   + +
Sbjct: 825 LDRALQEHAGRYSCVATNTAGSQHRDV 851



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 35/141 (24%), Positives = 58/141 (41%), Gaps = 17/141 (12%)

Query: 189 LQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHT 246
           +Q+P    P  +  A +    EG   +L C  +G P P + W  +   L S+  +     
Sbjct: 855 VQVP----PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSK 910

Query: 247 QGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSD-------- 298
           +G+L I   S+ D+G  + C A N VG     + L+V+  P I    S  ++        
Sbjct: 911 EGTLLIAQPSAQDAGAYV-CTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAK 969

Query: 299 --HHWCIPFTVKGNPKPALQW 317
                 +    KG+P P + W
Sbjct: 970 AGEEVTLDCEAKGSPPPLVTW 990



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/124 (27%), Positives = 49/124 (39%), Gaps = 5/124 (4%)

Query: 197 PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNIS 256
           PS +     + V  G+   L C  +G P P + W  G L      E S + G LRI    
Sbjct: 581 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-SSGKLRIPAAQ 639

Query: 257 SDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS---DHHWCIPFTVKGNPKP 313
             D+G   +C A N +G+    + L V  AP +T L    +        +     G P P
Sbjct: 640 ERDAG-TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP 698

Query: 314 ALQW 317
            + W
Sbjct: 699 TVTW 702



 Score = 33.9 bits (76), Expect = 0.40
 Identities = 28/109 (25%), Positives = 39/109 (35%), Gaps = 4/109 (3%)

Query: 198  SANLAAP-NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSH--TQGSLRITN 254
            S N   P  +T + G+ +TL C   G P P + W   +     +         GSLR+  
Sbjct: 957  SRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQ 1016

Query: 255  ISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCI 303
            +   DSG    C A N  G       L V    +      P   H  C+
Sbjct: 1017 VQVGDSG-HYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACL 1064


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 64/231 (27%), Positives = 94/231 (40%), Gaps = 22/231 (9%)

Query: 162 LQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVA 221
           L+ +K+   T +  C   S      A  QI     P   + APN+TV  G++  LSC V 
Sbjct: 484 LRASKAEEGTYE--CTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 541

Query: 222 GDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSV 279
           G+   N+ W  D   L +           SL I+ I   D G+   CVA N  G  + SV
Sbjct: 542 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGR-YQCVASNANGVTRASV 600

Query: 280 NLTVHFAPTITFLESPTSDHHWCIPFTVK------GNPKPALQWFYNGAILNESKYICTK 333
            L V  AP ++     TS  H+     VK      G P P + W      L E   I   
Sbjct: 601 WLLVREAPQVSI---HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI--- 654

Query: 334 IHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGI 384
                H +  G L +      + G+Y+  A NE G D++ ++ ++   P +
Sbjct: 655 -----HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV 700



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 18/223 (8%)

Query: 162  LQEAKSSPDTQDLY-CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSV 220
            L+ A +SP+    Y C+ ++S    +   ++     P      P+L+  EG    L C  
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 4061

Query: 221  AGDPVPNMYWDV-GNLVSKHMNE-TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDS 278
             G P PN+ WD  G  VS    + T    G L + N+   D+G   +C AEN VG  +  
Sbjct: 4062 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAG-TYTCTAENAVGRARRR 4120

Query: 279  VNLTVHFAPTITFLESPTS----DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI 334
            V+LT+   P  T L    S    D  W +    +G+P P + W  N   + E        
Sbjct: 4121 VHLTILVLPVFTTLPGDRSLRLGDRLW-LRCAARGSPTPRIGWTVNDRPVTEG------- 4172

Query: 335  HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
               +  +    LQ    +  ++G Y   A+N  G+ +     H
Sbjct: 4173 --VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVH 4213



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/164 (30%), Positives = 69/164 (42%), Gaps = 17/164 (10%)

Query: 211  GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQ-GSLRITNISSDDSGKQISCVAE 269
            G SI L C V GDPVP+++W    L  +  +     Q GSL I     DD+G+   C+AE
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGR-YQCLAE 4291

Query: 270  NLVGEDQDSVNLTVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYNGAIL 324
            N +G  +  V L +  AP   F   P      S     +     G P P ++W   G  L
Sbjct: 4292 NEMGVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 4349

Query: 325  NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
              S+ +         T   G L L+N    + G Y  +A N  G
Sbjct: 4350 RASRRL--------RTLPDGSLWLENVETGDAGTYDCVAHNLLG 4385



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 44/179 (24%), Positives = 76/179 (42%), Gaps = 18/179 (10%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQG--SLRITNISSDDSGKQ 263
            + V E   + L C   G P PN+ W     +     +  +T+G   L++    S D+G  
Sbjct: 1512 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAG-V 1570

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTI------TFLESPTSDHHWCIPFTVKGNPKPALQW 317
             +C A N VG  + +  L V+  PTI       ++    +     +    +G+P P L W
Sbjct: 1571 YTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW 1630

Query: 318  FYNGAILNESKYICTKIHVTNHTEYHG-CLQLDNPTHMNNGDYTLIAKNEYGKDEKQIS 375
             + G  + ES          +  E  G  L+L++P   ++G Y+ +A +  G+   Q S
Sbjct: 1631 HHEGLPVAESN--------ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYS 1681



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/166 (29%), Positives = 71/166 (42%), Gaps = 15/166 (9%)

Query: 214  ITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQGSLRITNISS---DDSGKQISCVAE 269
            + L+C+  G P P + W   GN VS             R+  ++S    DSG+  SCVA 
Sbjct: 1995 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY-SCVAV 2053

Query: 270  NLVGEDQDSVNLTVHFAPTITFLE---SPTSDHHWCIPFTVKGNPKPALQWFYNGAILNE 326
            + VGED+  V L VH  P+I   E   S  ++    +       P P L W+ +G  L  
Sbjct: 2054 SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 2113

Query: 327  SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
                   +H++        LQ+D     + G YT  A N+ G  EK
Sbjct: 2114 R----PGVHLSAD---KALLQVDRADVWDAGHYTCEALNQAGHSEK 2152



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 46/206 (22%), Positives = 87/206 (42%), Gaps = 21/206 (10%)

Query: 176 CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL 235
           C+  ++  +  A++ +     P  ++   +    +G  + +SCS +G P P++ W   + 
Sbjct: 587 CVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW---SR 643

Query: 236 VSKHMNETSH----TQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITF 291
            S+ + E S      QG+L I  ++ +D+G   SC A N VG DQ++V L     P+++ 
Sbjct: 644 ESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY-SCQATNEVGTDQETVTLYYTDPPSVSA 702

Query: 292 LES---PTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQL 348
           + +           +     G P P + W+  G           ++ +       G L++
Sbjct: 703 VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG----------LEMILAPEGSSSGKLRI 752

Query: 349 DNPTHMNNGDYTLIAKNEYGKDEKQI 374
                 + G YT  A NE G    +I
Sbjct: 753 PAAQERDAGTYTCRAVNELGDASAEI 778



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 52/224 (23%), Positives = 93/224 (41%), Gaps = 19/224 (8%)

Query: 164  EAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGD 223
            +A S+ D+ D  C   ++        ++    +P+     P + V   ++  L C   G 
Sbjct: 3640 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 3699

Query: 224  PVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNL 281
            P P + W  D   L  +        +GSLRI  + + D+G  + C+A N  G D+   +L
Sbjct: 3700 PAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL-CLASNSAGSDRQGRDL 3758

Query: 282  TVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYNGAILN-ESKYICTKIH 335
             V   P I    SP     T+     +P    G+PKP + W+ +G  L+   +    ++ 
Sbjct: 3759 RVLEPPAIA--PSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL 3816

Query: 336  VTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK--QISAH 377
             +N       L L  P   ++  +  +  NE G+  +  Q++ H
Sbjct: 3817 PSN------ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVH 3854



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 52/191 (27%), Positives = 77/191 (40%), Gaps = 22/191 (11%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263
            + V +G++  L C+V G P P + W  D   L     +  S     L++   +   +G  
Sbjct: 2455 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAG-H 2513

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGN----------PKP 313
             SC+A N VGE      L+V  APTI      ++D    +  TV             P P
Sbjct: 2514 YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEE--VTVTVNNPISLICEALAFPSP 2571

Query: 314  ALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ 373
             + W  +GA    S+     I +   T  HG LQ+ N    + G YT +  NE G+  K 
Sbjct: 2572 NITWMKDGAPFEASR----NIQLLPGT--HG-LQILNAQKEDAGQYTCVVTNELGEAVKN 2624

Query: 374  ISAHFMGWPGI 384
                 +  P I
Sbjct: 2625 YHVEVLIPPSI 2635



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 54/202 (26%), Positives = 80/202 (39%), Gaps = 17/202 (8%)

Query: 179  ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL-VS 237
            ES + + L  L  PN      N A     V E  S+TL C  +G P P++ W  G+  VS
Sbjct: 1873 ESKREVALKVLVPPNIEPGPVNKA-----VLENASVTLECLASGVPPPDVSWFKGHQPVS 1927

Query: 238  KHMNETSHTQGS-LRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPT 296
              M  T    G  LRI      D+G    CVA N+ G  +    L V+  P IT   S  
Sbjct: 1928 SWMGVTVSVDGRVLRIEQAQLSDAG-SYRCVASNVAGSTELRYGLRVNVPPRITLPPSLP 1986

Query: 297  SDHHWCIPF----TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPT 352
                   P        G P P L W  +G  ++ +     ++           L L +  
Sbjct: 1987 GPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV-----LTLASAR 2041

Query: 353  HMNNGDYTLIAKNEYGKDEKQI 374
              ++G Y+ +A +  G+D + +
Sbjct: 2042 ASDSGRYSCVAVSAVGEDRQDV 2063



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 51/171 (29%), Positives = 66/171 (38%), Gaps = 18/171 (10%)

Query: 211  GKSITLSCSVAGDPVPNMYWDVGNLV----SKHMNETSHTQGSLRITNISSDDSGKQISC 266
            G  + L C  +G P P + W            H+      Q  LRIT     D G+   C
Sbjct: 1423 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ-VLRITGSHVGDEGR-YQC 1480

Query: 267  VAENLVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNG 321
            VA +  G+      L VH  PTI     T   +   DH   +    +G P P + WF +G
Sbjct: 1481 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 1540

Query: 322  AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
            A+L  S    TK+  T        LQL      + G YT  A N  G  EK
Sbjct: 1541 ALLPTS----TKVVYTRGGRQ---LQLGRAQSSDAGVYTCKASNAVGAAEK 1584



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 29/202 (14%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQG-SLRITNISSDDSGKQ 263
            +T   G+ + L C  +G PVP + W   G    +       +QG +L I ++  D SG  
Sbjct: 1699 VTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG-L 1757

Query: 264  ISCVAENLVGEDQDSVNLTVH--FAPTITFLESPTSDHHW-----------CIPFTVKG- 309
             +C A N  G     V ++VH  +AP +  LE P   +HW           C P   +G 
Sbjct: 1758 FACQATNEAGTAGAEVEVSVHGEWAPGV--LEVPIGQYHWGXEHHSSFPAACDPPVHRGW 1815

Query: 310  --NPKPAL--QWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
              +PKP L   W   G++  E   I     +         LQ++     + G YT  A N
Sbjct: 1816 GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP------LQIEKVDLRDEGIYTCAATN 1869

Query: 366  EYGKDEKQISAHFMGWPGIDDG 387
              G+ +++++   +  P I+ G
Sbjct: 1870 LAGESKREVALKVLVPPNIEPG 1891



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 15/169 (8%)

Query: 211  GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAEN 270
            G  + L C+  G P P + W V +              +L+   +S +DSG  + C AEN
Sbjct: 4143 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYV-CWAEN 4201

Query: 271  LVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILN 325
             VG  Q    + V  AP +     ++L  P       +   V+G+P P + W  +G  L 
Sbjct: 4202 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQ-LDCVVRGDPVPDIHWIKDGLPLR 4260

Query: 326  ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
             S           H   +G L +      + G Y  +A+NE G  +K +
Sbjct: 4261 GSHL--------RHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVV 4301



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 44/187 (23%), Positives = 69/187 (36%), Gaps = 18/187 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQIS 265
            L++  G  + L C   G P PN+ W         +   S     LR+      D+G   +
Sbjct: 3505 LSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR-----DAG-LYT 3558

Query: 266  CVAENLVGEDQDSVNLTVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYN 320
            C+AE+  G  + S  + V   P I     P      +     +  +V+  P P + W  +
Sbjct: 3559 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRD 3618

Query: 321  GAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMG 380
            G +L E  +       T   E    LQL   +  ++GDY+  A+N  G            
Sbjct: 3619 GIVLQEDAH-------TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT 3671

Query: 381  WPGIDDG 387
             P I  G
Sbjct: 3672 VPTIRSG 3678



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 21/189 (11%)

Query: 208  VEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNETSHTQG-SLRITNISSDDSGKQIS 265
            V++G + TL C+  G P P + W+  G  V   +      QG SL +    +  +G+  S
Sbjct: 2271 VQDGVA-TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRY-S 2328

Query: 266  CVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCI--PFTV----KGNPKPALQWFY 319
            CVAENL G  +    L+V   P +     P ++    +  P T+     G P PA++WF 
Sbjct: 2329 CVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR 2388

Query: 320  NGAILN--ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
                ++  E  Y+     +         L++      ++G Y+ +A NE G+  +  S  
Sbjct: 2389 GEEPVSPGEDTYLLAGGWM---------LKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 2439

Query: 378  FMGWPGIDD 386
             +  P I++
Sbjct: 2440 VLVPPSIEN 2448



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 54/196 (27%), Positives = 77/196 (39%), Gaps = 25/196 (12%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGS--LRITNISSDDSGK 262
            N+T      +TL C   G P P + W  G        +T    G   L++T     DSG 
Sbjct: 2361 NITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG- 2419

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPT---------ITFLESPTSDHHWCIPFTVKGNPKP 313
              SC+A N  GE + + ++ V   P+         I  L+  T+ H  C    V G+P+P
Sbjct: 2420 LYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTA-HLMC---NVTGHPQP 2475

Query: 314  ALQWFYNGAILNESKYICTKIHVTNHTEYHG-CLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
             L WF +G  L             +H    G  LQ+      + G Y+ IA N  G+  K
Sbjct: 2476 KLTWFKDGRPLARGD--------AHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTK 2527

Query: 373  QISAHFMGWPGIDDGA 388
                  +  P I  GA
Sbjct: 2528 HFQLSVLLAPTILGGA 2543



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 45/187 (24%), Positives = 77/187 (41%), Gaps = 15/187 (8%)

Query: 211  GKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA 268
            G  + L+C V+G P P + W  D   + S  ++      G L+++ +    +G   +CVA
Sbjct: 3139 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAG-TYTCVA 3197

Query: 269  ENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWC------IPFTVKGNPKPALQWFYNGA 322
            EN   E +    + V  AP I        +HH        +     G P P + W  +G+
Sbjct: 3198 ENTQAEARKDFVVAVLVAPRIR-SSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGS 3256

Query: 323  ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWP 382
             L +      + ++       G L L      + G YT +A N  G+D +  + + +  P
Sbjct: 3257 PLGQDMGPHLRFYLDG-----GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP 3311

Query: 383  GIDDGAN 389
             I  GA+
Sbjct: 3312 TIKQGAD 3318



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 20/178 (11%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNL---VSKHMNETSHTQGSLRITNISSDDSGK 262
            +TV    +++L C   G+PVP + W    L    S  +      Q  L+++     D+  
Sbjct: 2855 VTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ-VLQVSTAEVADAAS 2913

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLE----SPTSDHHWCIPFTVKGNPKPALQWF 318
             + CVAEN  G  +    L V   P I  L+    +   +    +P  V  +P P + W+
Sbjct: 2914 YM-CVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY 2972

Query: 319  YNGAILN--ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
             +   L+  E  ++    H          LQL      ++G YT  A N  G+D+K +
Sbjct: 2973 KDSQALSLGEEVFLLPGTHT---------LQLGRARLSDSGMYTCEALNAAGRDQKLV 3021



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 19/193 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQIS 265
            L V  G+++ L+C   G+P P + W    +V +        QGS+    I + D+G+   
Sbjct: 1129 LKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG----PQGSVHFAAIRTSDAGR-YR 1183

Query: 266  CVAENLVGEDQDSVNLTVHFAP------TITFLESPTSDHHWCIPFTVKGNPKPALQWFY 319
            C A N  G D   V L V   P      T   LE    ++   +P   +G PKP + W  
Sbjct: 1184 CEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENA-SLPCPARGTPKPQVTWRK 1242

Query: 320  NGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFM 379
              +  +E  +    + V       G L L + +  ++GDY   A NE G   ++      
Sbjct: 1243 GPS--SEPLHGQPGVAVLE----EGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVY 1296

Query: 380  GWPGI-DDGANPN 391
              P I +DG   N
Sbjct: 1297 VPPSIREDGRKAN 1309



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 45/182 (24%), Positives = 68/182 (37%), Gaps = 15/182 (8%)

Query: 211  GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-HTQGSLRITNISSDDSGKQISCVAE 269
            G+ + L C   G P P + W    L     NE+   T GS+       + S    SCVA 
Sbjct: 1611 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 1670

Query: 270  NLVGEDQDSVNLTVHFAPTITFLE-----SPTSDHHWCIPFTVKGNPKPALQWFYNGAIL 324
            +  GE     ++ V   P +   E     +        +P    G+P P +QW  NG   
Sbjct: 1671 SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPA 1730

Query: 325  NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK--DEKQISAHFMGWP 382
             E   +      T        L +D+    ++G +   A NE G    E ++S H    P
Sbjct: 1731 EELAGVQVASQGTT-------LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAP 1783

Query: 383  GI 384
            G+
Sbjct: 1784 GV 1785



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 56/253 (22%), Positives = 100/253 (39%), Gaps = 41/253 (16%)

Query: 147  GNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLN---ESSKNIPLANLQIPNCGLPSANLAA 203
            G+    S D + ++ LQ   SS         N   E +K+  L+ L  P     + + A 
Sbjct: 2489 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 2548

Query: 204  PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL---VSKHMNETSHTQGSLRITNISSDDS 260
              +TV     I+L C     P PN+ W         S+++     T G L+I N   +D+
Sbjct: 2549 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDA 2607

Query: 261  GKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSD------------------HHWC 302
            G Q +CV  N +GE   + ++ V   P+I+  + P  +                    W 
Sbjct: 2608 G-QYTCVVTNELGEAVKNYHVEVLIPPSIS-KDDPLGEVGVKEVKTKVNSTLTLECESWA 2665

Query: 303  IPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLI 362
            +       P P ++W+ +G  +  S    +++ V         LQ+      ++G Y  +
Sbjct: 2666 V-------PPPTIRWYKDGQPVTPS----SRLQVLGEGR---LLQIQPTQVSDSGRYLCV 2711

Query: 363  AKNEYGKDEKQIS 375
            A N  G+D++  +
Sbjct: 2712 ATNVAGEDDQDFN 2724



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/207 (23%), Positives = 74/207 (35%), Gaps = 33/207 (15%)

Query: 187 ANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGN--------LVSK 238
           A +Q+     P       ++TVE G+S  L+C   G P P + W  G+           +
Sbjct: 776 AEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR 835

Query: 239 HMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV---------HFAPTI 289
                    G L   +++ +D    + C A N+ G+ Q    L V           APT+
Sbjct: 836 GSRSRQPDSGVLFFESVAPEDQAPYV-CEARNVFGKVQAEARLIVTGHAPPQIASSAPTV 894

Query: 290 TFLE-SPTSDHHWCIP-FTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQ 347
             LE  P S     +P   + G P P   W  +G  L             +     G L 
Sbjct: 895 RVLEGQPVS-----LPCIVLAGRPLPERHWLKDGRPLPPGS--------RHSIRADGSLH 941

Query: 348 LDNPTHMNNGDYTLIAKNEYGKDEKQI 374
           LD     + G Y+ +A N  G   + +
Sbjct: 942 LDRALQEHAGRYSCVATNTAGSQHRDV 968



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 53/210 (25%), Positives = 90/210 (42%), Gaps = 27/210 (12%)

Query: 179  ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-----DVG 233
            E+ K+  +A L  P   + S+ +A  +  V EG+ + L C   G P P++ W      +G
Sbjct: 3203 EARKDFVVAVLVAPR--IRSSGVAREH-HVLEGQEVRLDCEADGQPPPDVAWLKDGSPLG 3259

Query: 234  NLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTI---- 289
              +  H+       GSL +  + + D+G   +CVA N  GED     + V   PTI    
Sbjct: 3260 QDMGPHL-RFYLDGGSLVLKGLRASDAG-AYTCVAHNPAGEDARLHTVNVLVPPTIKQGA 3317

Query: 290  ----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGC 345
                T +  P        P  V+G+P   + W  +G  L  S+   T +H + HT     
Sbjct: 3318 DGSGTLVSRPGELVTMVCP--VRGSPPIHVSWLKDGLPLPLSQR--TLLHGSGHT----- 3368

Query: 346  LQLDNPTHMNNGDYTLIAKNEYGKDEKQIS 375
            L++      + G +T +A +  G  ++  +
Sbjct: 3369 LRISKVQLADAGIFTCVAASPAGVADRNFT 3398



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 29/113 (25%), Positives = 46/113 (40%), Gaps = 2/113 (1%)

Query: 176  CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-DVGN 234
            CL E+   +    + +     P   +   ++TV  G  + L C   G+P P + W   G 
Sbjct: 4288 CLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ 4347

Query: 235  LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
             +       +   GSL + N+ + D+G    CVA NL+G       L V   P
Sbjct: 4348 PLRASRRLRTLPDGSLWLENVETGDAG-TYDCVAHNLLGSATARAFLVVRGEP 4399



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 47/187 (25%), Positives = 71/187 (37%), Gaps = 19/187 (10%)

Query: 197  PSANLAAPNLTVEEGKSITLSCSVAGDPVPNM-YWDVGNLVSKHMNETSHT---QGSLRI 252
            P+   +  NLT+       L C  +G P P + +W  G  +   + + ++      +L +
Sbjct: 3764 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLL 3823

Query: 253  TNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESP---TSDHHWCIPFTVKG 309
            T     DS  Q  CV  N VGE      +TVH  PTI   ++    T      +     G
Sbjct: 3824 TAPGPQDSA-QFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 3882

Query: 310  NPKPALQWFYNGAILNE--SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEY 367
             P P + W   GA L    S Y              G L++     ++ G YT  A+N  
Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGY---------RVSPSGALEIGQALPIHAGRYTCSARNSA 3933

Query: 368  GKDEKQI 374
            G   K +
Sbjct: 3934 GVAHKHV 3940



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 14/169 (8%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSHTQGSLRITNISSDDSGK 262
            + TV     + L+C   G P P + W      L ++         G+L I       +G+
Sbjct: 3865 DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR 3924

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLES---PTSDHHWCIPFTVKGNPKPALQWFY 319
              +C A N  G     V LTV  +P +  L S     ++    +P    G P+P + W  
Sbjct: 3925 Y-TCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK 3983

Query: 320  NGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
             G  LN +  + T++         G L++ + +  + G+Y  IAKN  G
Sbjct: 3984 EG--LNVATGVSTQVLP------GGQLRIAHASPEDAGNYLCIAKNSAG 4024



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 46/192 (23%), Positives = 75/192 (39%), Gaps = 19/192 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-HTQG-SLRITNISSDDSGKQ 263
            L    G+ +T+ C V G P  ++ W    L       T  H  G +LRI+ +   D+G  
Sbjct: 3323 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI- 3381

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQWF 318
             +CVA +  G    +  L V   P +  +E              +P   +G P P + W 
Sbjct: 3382 FTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWM 3441

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHF 378
             +G  L           ++   E    LQL+     ++G Y+ +A +E G+  +      
Sbjct: 3442 KDGEPL-----------LSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 3490

Query: 379  MGWPGIDDGANP 390
            M  P I+D   P
Sbjct: 3491 MEPPHIEDSGQP 3502



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 41/194 (21%), Positives = 70/194 (36%), Gaps = 16/194 (8%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ- 263
            LTV EG   +LSC   G P P + W   G  +        H     R+  +      ++ 
Sbjct: 2172 LTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 2231

Query: 264  -ISCVAENLVGEDQDSVNLTVHFAPTITFLESP------TSDHHWCIPFTVKGNPKPALQ 316
              +C   N+VG     + L VH  P I     P        D    +     G P P + 
Sbjct: 2232 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVT 2291

Query: 317  WFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISA 376
            W  +G  +         + + N  +    L ++     + G Y+ +A+N  G+ E++   
Sbjct: 2292 WERDGQPVGAE----LGLQLQNQGQ---SLHVERAQAAHTGRYSCVAENLAGRAERKFEL 2344

Query: 377  HFMGWPGIDDGANP 390
              +  P +    +P
Sbjct: 2345 SVLVPPELIGDLDP 2358



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/124 (27%), Positives = 49/124 (39%), Gaps = 5/124 (4%)

Query: 197 PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNIS 256
           PS +     + V  G+   L C  +G P P + W  G L      E S + G LRI    
Sbjct: 698 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-SSGKLRIPAAQ 756

Query: 257 SDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS---DHHWCIPFTVKGNPKP 313
             D+G   +C A N +G+    + L V  AP +T L    +        +     G P P
Sbjct: 757 ERDAG-TYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP 815

Query: 314 ALQW 317
            + W
Sbjct: 816 TVTW 819



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 56/226 (24%), Positives = 77/226 (34%), Gaps = 25/226 (11%)

Query: 161  TLQEAKSSPDTQDLY---CLNESSKNIPLANLQIPNCGLPSANLAAPN-----LTVEEGK 212
            TLQ  ++      +Y    LN + ++  L  L +    +P A   AP      + V  G 
Sbjct: 2992 TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL---VPPAFRQAPRGPQDAVLVRVGD 3048

Query: 213  SITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAEN 270
               LSC     P P + W  D   LV     +       L I      D G   SC   N
Sbjct: 3049 KAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY-SCKVSN 3107

Query: 271  LVGEDQDSVNLTVHFAPTI----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNE 326
            + GE   +  LTV   PT     T   S  +     +   V G P P + W  +   +  
Sbjct: 3108 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 3167

Query: 327  SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
            S        V       G LQL        G YT +A+N   +  K
Sbjct: 3168 SA-------VHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 3206



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/195 (24%), Positives = 77/195 (39%), Gaps = 26/195 (13%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGK 262
            ++ V  G  + L C   G P+P + W  D   L+S+ + +      SL++  + + DSG 
Sbjct: 3415 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGP----SLQLEAVGAGDSG- 3469

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQW 317
              SCVA +  GE +    LTV   P I     PT           +    +G P+P + W
Sbjct: 3470 TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITW 3529

Query: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
              +G  L           + N++     L++      + G YT +A++  G  EK     
Sbjct: 3530 HKDGQALT---------RLENNSRATRVLRV-----RDAGLYTCLAESPAGAIEKSFRVR 3575

Query: 378  FMGWPGIDDGANPNY 392
                P I     P +
Sbjct: 3576 VQAPPNIVGPRGPRF 3590



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/174 (25%), Positives = 69/174 (39%), Gaps = 17/174 (9%)

Query: 208  VEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGS--LRITNISSDDSGKQIS 265
            + E     L C     P P++ W   +      +E S  QG   L+I  + ++++G+  S
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY-S 2820

Query: 266  CVAENLVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPF--TVKGNPKPALQWF 318
            C A N VGED     L V   P I       +E  T +    +       GNP P + W 
Sbjct: 2821 CKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 2880

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
             NG   + S     ++ V    +    LQ+      +   Y  +A+N+ G  EK
Sbjct: 2881 QNGLPFSPS----PRLQVLEDGQ---VLQVSTAEVADAASYMCVAENQAGSAEK 2927



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 27/98 (27%), Positives = 45/98 (45%), Gaps = 7/98 (7%)

Query: 189  LQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHT 246
            +Q+P    P  +  A +    EG   +L C  +G P P + W  +   L S+  +     
Sbjct: 972  VQVP----PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSK 1027

Query: 247  QGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVH 284
            +G+L I   S+ D+G  + C A N VG     + L+V+
Sbjct: 1028 EGTLLIAQPSAQDAGAYV-CTATNTVGFSSQEMRLSVN 1064



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 42/176 (23%), Positives = 61/176 (34%), Gaps = 12/176 (6%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGK 262
            N++V   +S+ L C     P P + W  D   L  +     S  +  L++      D+G 
Sbjct: 2079 NVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG- 2137

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLESPT----SDHHWCIPFTVKGNPKPALQWF 318
              +C A N  G  +   NL V  AP     ES T      H   +    +G P P + W 
Sbjct: 2138 HYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWR 2197

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
             +G  L         +       Y G  QL        G YT    N  G   + +
Sbjct: 2198 KDGQPLPGEGAGLQHVSAVGRLLYLGQAQL-----AQEGTYTCECSNVVGNSSQDL 2248



 Score = 34.7 bits (78), Expect = 0.23
 Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 5/115 (4%)

Query: 177  LNESSKNIPLANLQIPNCGL--PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-DVG 233
            L E+ KN  +  L  P+     P   +    +  +   ++TL C     P P + W   G
Sbjct: 2618 LGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDG 2677

Query: 234  NLVSKHMNETSHTQGSL-RITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
              V+         +G L +I      DSG+ + CVA N+ GED    N+ +   P
Sbjct: 2678 QPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYL-CVATNVAGEDDQDFNVLIQVPP 2731



 Score = 32.7 bits (73), Expect = 0.89
 Identities = 31/104 (29%), Positives = 40/104 (38%), Gaps = 22/104 (21%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYW------------------DVG-NLVSKHMNETSH 245
            N++   G+S+TL C   G PVP + W                  D+G   V  H      
Sbjct: 1309 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGH--RLLD 1366

Query: 246  TQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTI 289
               SL    I   DSG   SC AEN  G  Q   +L V   P++
Sbjct: 1367 EGQSLHFPRIQEGDSGLY-SCRAENQAGTAQRDFHLLVLTPPSV 1409



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 32/134 (23%), Positives = 49/134 (36%), Gaps = 14/134 (10%)

Query: 199  ANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQG--SLRITNIS 256
            A L    +T     S++L C V   P P + W   +       E     G  +L++    
Sbjct: 2940 AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRAR 2999

Query: 257  SDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH---------HWCIPFTV 307
              DSG   +C A N  G DQ  V L+V   P   F ++P                +    
Sbjct: 3000 LSDSG-MYTCEALNAAGRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCET 3056

Query: 308  KGNPKPALQWFYNG 321
               P+P + W+ +G
Sbjct: 3057 DALPEPTVTWYKDG 3070


>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
           sapiens]
          Length = 790

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 64/231 (27%), Positives = 94/231 (40%), Gaps = 22/231 (9%)

Query: 162 LQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVA 221
           L+ +K+   T +  C   S      A  QI     P   + APN+TV  G++  LSC V 
Sbjct: 483 LRASKAEEGTYE--CTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVL 540

Query: 222 GDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSV 279
           G+   N+ W  D   L +           SL I+ I   D G+   CVA N  G  + SV
Sbjct: 541 GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGR-YQCVASNANGVTRASV 599

Query: 280 NLTVHFAPTITFLESPTSDHHWCIPFTVK------GNPKPALQWFYNGAILNESKYICTK 333
            L V  AP ++     TS  H+     VK      G P P + W      L E   I   
Sbjct: 600 WLLVREAPQVSI---HTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRI--- 653

Query: 334 IHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGI 384
                H +  G L +      + G+Y+  A NE G D++ ++ ++   P +
Sbjct: 654 -----HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV 699



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 46/206 (22%), Positives = 87/206 (42%), Gaps = 21/206 (10%)

Query: 176 CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL 235
           C+  ++  +  A++ +     P  ++   +    +G  + +SCS +G P P++ W   + 
Sbjct: 586 CVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISW---SR 642

Query: 236 VSKHMNETSH----TQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITF 291
            S+ + E S      QG+L I  ++ +D+G   SC A N VG DQ++V L     P+++ 
Sbjct: 643 ESQALQEDSRIHVDAQGTLIIQGVAPEDAGNY-SCQATNEVGTDQETVTLYYTDPPSVSA 701

Query: 292 LES---PTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQL 348
           + +           +     G P P + W+  G           ++ +       G L++
Sbjct: 702 VNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG----------LEMILAPEGSSSGKLRI 751

Query: 349 DNPTHMNNGDYTLIAKNEYGKDEKQI 374
                 + G YT  A NE G    +I
Sbjct: 752 PAAQERDAGTYTCRAVNELGDASAEI 777



 Score = 34.7 bits (78), Expect = 0.23
 Identities = 26/87 (29%), Positives = 37/87 (42%), Gaps = 2/87 (2%)

Query: 197 PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNIS 256
           PS +     + V  G+   L C  +G P P + W  G L      E S + G LRI    
Sbjct: 697 PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS-SSGKLRIPAAQ 755

Query: 257 SDDSGKQISCVAENLVGEDQDSVNLTV 283
             D+G   +C A N +G+    + L V
Sbjct: 756 ERDAG-TYTCRAVNELGDASAEIQLAV 781


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 64/286 (22%), Positives = 115/286 (40%), Gaps = 39/286 (13%)

Query: 72  FIANQKRLEIIN-------EDDVEAYVGLRNLT---IVDSGLKFVAHKAFLKNSNLQHIN 121
           F++N + L++ N       ED  EA+ GL +LT   +  + +K +  KAF+   +L+H++
Sbjct: 357 FLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLD 416

Query: 122 FTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWI------KTLQEAKSSPDTQDLY 175
              N + S+    F    L ELIL  +   C C + W+         Q + +       +
Sbjct: 417 LNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEW 476

Query: 176 CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSV--AGDPVPNMYW--- 230
              +S  N+ L +    +   P        +    G ++TL+C+   + D   +  W   
Sbjct: 477 LAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKD 536

Query: 231 -------DVGNLVS--KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGED-QDSVN 280
                  D  N V   +   E       L + N++  D GK   C+  N  G +      
Sbjct: 537 SEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGK-YQCIVTNHFGSNYSQKAK 595

Query: 281 LTVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYNG 321
           LTV+  P  +FL++P      +     +    +G+P P + W  +G
Sbjct: 596 LTVNEMP--SFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDG 639



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 3/114 (2%)

Query: 176 CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW--DVG 233
           C+ +++     AN  +     PS      + TV  G++  L C   G P P + W  D G
Sbjct: 675 CMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDG 734

Query: 234 NLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
            L+    +  +     L I +   +D+GK  +C+  N +G ++  + L V  +P
Sbjct: 735 PLLVTERHFFAAANQLLIIVDAGLEDAGK-YTCIMSNTLGTERGHIYLNVISSP 787


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 18/223 (8%)

Query: 162  LQEAKSSPDTQDLY-CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSV 220
            L+ A +SP+    Y C+ ++S    +   ++     P      P+L+  EG    L C  
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2870

Query: 221  AGDPVPNMYWDV-GNLVSKHMNE-TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDS 278
             G P PN+ WD  G  VS    + T    G L + N+   D+G   +C AEN VG  +  
Sbjct: 2871 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAG-TYTCTAENAVGRARRR 2929

Query: 279  VNLTVHFAPTITFLESPTS----DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI 334
            V+LT+   P  T L    S    D  W +    +G+P P + W  N   + E        
Sbjct: 2930 VHLTILVLPVFTTLPGDRSLRLGDRLW-LRCAARGSPTPRIGWTVNDRPVTEG------- 2981

Query: 335  HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
               +  +    LQ    +  ++G Y   A+N  G+ +     H
Sbjct: 2982 --VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVH 3022



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/164 (30%), Positives = 69/164 (42%), Gaps = 17/164 (10%)

Query: 211  GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQ-GSLRITNISSDDSGKQISCVAE 269
            G SI L C V GDPVP+++W    L  +  +     Q GSL I     DD+G+   C+AE
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGR-YQCLAE 3100

Query: 270  NLVGEDQDSVNLTVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYNGAIL 324
            N +G  +  V L +  AP   F   P      S     +     G P P ++W   G  L
Sbjct: 3101 NEMGVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3158

Query: 325  NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
              S+ +         T   G L L+N    + G Y  +A N  G
Sbjct: 3159 RASRRL--------RTLPDGSLWLENVETGDAGTYDCVAHNLLG 3194



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 44/179 (24%), Positives = 76/179 (42%), Gaps = 18/179 (10%)

Query: 206 LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQG--SLRITNISSDDSGKQ 263
           + V E   + L C   G P PN+ W     +     +  +T+G   L++    S D+G  
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAG-V 379

Query: 264 ISCVAENLVGEDQDSVNLTVHFAPTI------TFLESPTSDHHWCIPFTVKGNPKPALQW 317
            +C A N VG  + +  L V+  PTI       ++    +     +    +G+P P L W
Sbjct: 380 YTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW 439

Query: 318 FYNGAILNESKYICTKIHVTNHTEYHG-CLQLDNPTHMNNGDYTLIAKNEYGKDEKQIS 375
            + G  + ES          +  E  G  L+L++P   ++G Y+ +A +  G+   Q S
Sbjct: 440 HHEGLPVAESN--------ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYS 490



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 49/166 (29%), Positives = 72/166 (43%), Gaps = 15/166 (9%)

Query: 214 ITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQGSLRITNISS---DDSGKQISCVAE 269
           + L+C+  G P P + W   GN VS             R+  ++S    DSG+  SCVA 
Sbjct: 804 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY-SCVAV 862

Query: 270 NLVGEDQDSVNLTVHFAPTITFLE---SPTSDHHWCIPFTVKGNPKPALQWFYNGAILNE 326
           + VGED+  V L VH  P+I   E   S  ++    +       P P L W+ +G  L  
Sbjct: 863 SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 922

Query: 327 SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
                  +H++        LQ+D     + G YT  A N+ G+ EK
Sbjct: 923 R----PGVHLSAD---KALLQVDRADVWDAGHYTCEALNQAGRSEK 961



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 52/224 (23%), Positives = 93/224 (41%), Gaps = 19/224 (8%)

Query: 164  EAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGD 223
            +A S+ D+ D  C   ++        ++    +P+     P + V   ++  L C   G 
Sbjct: 2449 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2508

Query: 224  PVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNL 281
            P P + W  D   L  +        +GSLRI  + + D+G  + C+A N  G D+   +L
Sbjct: 2509 PAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL-CLASNSAGSDRQGRDL 2567

Query: 282  TVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYNGAILN-ESKYICTKIH 335
             V   P I    SP     T+     +P    G+PKP + W+ +G  L+   +    ++ 
Sbjct: 2568 RVLEPPAIA--PSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL 2625

Query: 336  VTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK--QISAH 377
             +N       L L  P   ++  +  +  NE G+  +  Q++ H
Sbjct: 2626 PSN------ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVH 2663



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 52/191 (27%), Positives = 77/191 (40%), Gaps = 22/191 (11%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263
            + V +G++  L C+V G P P + W  D   L     +  S     L++   +   +G  
Sbjct: 1264 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAG-H 1322

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGN----------PKP 313
             SC+A N VGE      L+V  APTI      ++D    +  TV             P P
Sbjct: 1323 YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEE--VTVTVNNPISLICEALAFPSP 1380

Query: 314  ALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ 373
             + W  +GA    S+     I +   T  HG LQ+ N    + G YT +  NE G+  K 
Sbjct: 1381 NITWMKDGAPFEASR----NIQLLPGT--HG-LQILNAQKEDAGQYTCVVTNELGEAVKN 1433

Query: 374  ISAHFMGWPGI 384
                 +  P I
Sbjct: 1434 YHVEVLIPPSI 1444



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 54/202 (26%), Positives = 80/202 (39%), Gaps = 17/202 (8%)

Query: 179 ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL-VS 237
           ES + + L  L  PN      N A     V E  S+TL C  +G P P++ W  G+  VS
Sbjct: 682 ESKREVALKVLVPPNIEPGPVNKA-----VLENASVTLECLASGVPPPDVSWFKGHQPVS 736

Query: 238 KHMNETSHTQGS-LRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPT 296
             M  T    G  LRI      D+G    CVA N+ G  +    L V+  P IT   S  
Sbjct: 737 SWMGVTVSVDGRVLRIEQAQLSDAG-SYRCVASNVAGSTELRYGLRVNVPPRITLPPSLP 795

Query: 297 SDHHWCIPF----TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPT 352
                  P        G P P L W  +G  ++ +     ++           L L +  
Sbjct: 796 GPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV-----LTLASAR 850

Query: 353 HMNNGDYTLIAKNEYGKDEKQI 374
             ++G Y+ +A +  G+D + +
Sbjct: 851 ASDSGRYSCVAVSAVGEDRQDV 872



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 51/171 (29%), Positives = 66/171 (38%), Gaps = 18/171 (10%)

Query: 211 GKSITLSCSVAGDPVPNMYWDVGNLV----SKHMNETSHTQGSLRITNISSDDSGKQISC 266
           G  + L C  +G P P + W            H+      Q  LRIT     D G+   C
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ-VLRITGSHVGDEGR-YQC 289

Query: 267 VAENLVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNG 321
           VA +  G+      L VH  PTI     T   +   DH   +    +G P P + WF +G
Sbjct: 290 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 349

Query: 322 AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
           A+L  S    TK+  T        LQL      + G YT  A N  G  EK
Sbjct: 350 ALLPTS----TKVVYTRGGRQ---LQLGRAQSSDAGVYTCKASNAVGAAEK 393



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 29/202 (14%)

Query: 206 LTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQG-SLRITNISSDDSGKQ 263
           +T   G+ + L C  +G PVP + W   G    +       +QG +L I ++  D SG  
Sbjct: 508 VTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG-L 566

Query: 264 ISCVAENLVGEDQDSVNLTVH--FAPTITFLESPTSDHHW-----------CIPFTVKG- 309
            +C A N  G     V ++VH  +AP +  LE P   +HW           C P   +G 
Sbjct: 567 FACQATNEAGTAGAEVEVSVHGEWAPGV--LEVPIGQYHWGXEHHSSFPAACDPPVHRGW 624

Query: 310 --NPKPAL--QWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
             +PKP L   W   G++  E   I     +         LQ++     + G YT  A N
Sbjct: 625 GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP------LQIEKVDLRDEGIYTCAATN 678

Query: 366 EYGKDEKQISAHFMGWPGIDDG 387
             G+ +++++   +  P I+ G
Sbjct: 679 LAGESKREVALKVLVPPNIEPG 700



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 15/169 (8%)

Query: 211  GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAEN 270
            G  + L C+  G P P + W V +              +L+   +S +DSG  + C AEN
Sbjct: 2952 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYV-CWAEN 3010

Query: 271  LVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILN 325
             VG  Q    + V  AP +     ++L  P       +   V+G+P P + W  +G  L 
Sbjct: 3011 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQ-LDCVVRGDPVPDIHWIKDGLPLR 3069

Query: 326  ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
             S           H   +G L +      + G Y  +A+NE G  +K +
Sbjct: 3070 GSHL--------RHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVV 3110



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 44/187 (23%), Positives = 69/187 (36%), Gaps = 18/187 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQIS 265
            L++  G  + L C   G P PN+ W         +   S     LR+      D+G   +
Sbjct: 2314 LSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR-----DAG-LYT 2367

Query: 266  CVAENLVGEDQDSVNLTVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYN 320
            C+AE+  G  + S  + V   P I     P      +     +  +V+  P P + W  +
Sbjct: 2368 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRD 2427

Query: 321  GAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMG 380
            G +L E  +       T   E    LQL   +  ++GDY+  A+N  G            
Sbjct: 2428 GIVLQEDAH-------TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT 2480

Query: 381  WPGIDDG 387
             P I  G
Sbjct: 2481 VPTIRSG 2487



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 21/189 (11%)

Query: 208  VEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNETSHTQG-SLRITNISSDDSGKQIS 265
            V++G + TL C+  G P P + W+  G  V   +      QG SL +    +  +G+  S
Sbjct: 1080 VQDGVA-TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRY-S 1137

Query: 266  CVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCI--PFTV----KGNPKPALQWFY 319
            CVAENL G  +    L+V   P +     P ++    +  P T+     G P PA++WF 
Sbjct: 1138 CVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR 1197

Query: 320  NGAILN--ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
                ++  E  Y+     +         L++      ++G Y+ +A NE G+  +  S  
Sbjct: 1198 GEEPVSPGEDTYLLAGGWM---------LKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 1248

Query: 378  FMGWPGIDD 386
             +  P I++
Sbjct: 1249 VLVPPSIEN 1257



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 54/196 (27%), Positives = 77/196 (39%), Gaps = 25/196 (12%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGS--LRITNISSDDSGK 262
            N+T      +TL C   G P P + W  G        +T    G   L++T     DSG 
Sbjct: 1170 NITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG- 1228

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPT---------ITFLESPTSDHHWCIPFTVKGNPKP 313
              SC+A N  GE + + ++ V   P+         I  L+  T+ H  C    V G+P+P
Sbjct: 1229 LYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTA-HLMC---NVTGHPQP 1284

Query: 314  ALQWFYNGAILNESKYICTKIHVTNHTEYHG-CLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
             L WF +G  L             +H    G  LQ+      + G Y+ IA N  G+  K
Sbjct: 1285 KLTWFKDGRPLARGD--------AHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTK 1336

Query: 373  QISAHFMGWPGIDDGA 388
                  +  P I  GA
Sbjct: 1337 HFQLSVLLAPTILGGA 1352



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 45/187 (24%), Positives = 77/187 (41%), Gaps = 15/187 (8%)

Query: 211  GKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA 268
            G  + L+C V+G P P + W  D   + S  ++      G L+++ +    +G   +CVA
Sbjct: 1948 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAG-TYTCVA 2006

Query: 269  ENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWC------IPFTVKGNPKPALQWFYNGA 322
            EN   E +    + V  AP I        +HH        +     G P P + W  +G+
Sbjct: 2007 ENTQAEARKDFVVAVLVAPRIR-SSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGS 2065

Query: 323  ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWP 382
             L +      + ++       G L L      + G YT +A N  G+D +  + + +  P
Sbjct: 2066 PLGQDMGPHLRFYLDG-----GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP 2120

Query: 383  GIDDGAN 389
             I  GA+
Sbjct: 2121 TIKQGAD 2127



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 20/178 (11%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNL---VSKHMNETSHTQGSLRITNISSDDSGK 262
            +TV    +++L C   G+PVP + W    L    S  +      Q  L+++     D+  
Sbjct: 1664 VTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ-VLQVSTAEVADAAS 1722

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLE----SPTSDHHWCIPFTVKGNPKPALQWF 318
             + CVAEN  G  +    L V   P I  L+    +   +    +P  V  +P P + W+
Sbjct: 1723 YM-CVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY 1781

Query: 319  YNGAILN--ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
             +   L+  E  ++    H          LQL      ++G YT  A N  G+D+K +
Sbjct: 1782 KDSQALSLGEEVFLLPGTHT---------LQLGRARLSDSGMYTCEALNAAGRDQKLV 1830



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 45/182 (24%), Positives = 68/182 (37%), Gaps = 15/182 (8%)

Query: 211 GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-HTQGSLRITNISSDDSGKQISCVAE 269
           G+ + L C   G P P + W    L     NE+   T GS+       + S    SCVA 
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 479

Query: 270 NLVGEDQDSVNLTVHFAPTITFLE-----SPTSDHHWCIPFTVKGNPKPALQWFYNGAIL 324
           +  GE     ++ V   P +   E     +        +P    G+P P +QW  NG   
Sbjct: 480 SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPA 539

Query: 325 NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK--DEKQISAHFMGWP 382
            E   +      T        L +D+    ++G +   A NE G    E ++S H    P
Sbjct: 540 EELAGVQVASQGTT-------LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAP 592

Query: 383 GI 384
           G+
Sbjct: 593 GV 594



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 56/253 (22%), Positives = 100/253 (39%), Gaps = 41/253 (16%)

Query: 147  GNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLN---ESSKNIPLANLQIPNCGLPSANLAA 203
            G+    S D + ++ LQ   SS         N   E +K+  L+ L  P     + + A 
Sbjct: 1298 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1357

Query: 204  PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL---VSKHMNETSHTQGSLRITNISSDDS 260
              +TV     I+L C     P PN+ W         S+++     T G L+I N   +D+
Sbjct: 1358 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDA 1416

Query: 261  GKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSD------------------HHWC 302
            G Q +CV  N +GE   + ++ V   P+I+  + P  +                    W 
Sbjct: 1417 G-QYTCVVTNELGEAVKNYHVEVLIPPSIS-KDDPLGEVGVKEVKTKVNSTLTLECESWA 1474

Query: 303  IPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLI 362
            +       P P ++W+ +G  +  S    +++ V         LQ+      ++G Y  +
Sbjct: 1475 V-------PPPTIRWYKDGQPVTPS----SRLQVLGEGR---LLQIQPTQVSDSGRYLCV 1520

Query: 363  AKNEYGKDEKQIS 375
            A N  G+D++  +
Sbjct: 1521 ATNVAGEDDQDFN 1533



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 53/210 (25%), Positives = 90/210 (42%), Gaps = 27/210 (12%)

Query: 179  ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-----DVG 233
            E+ K+  +A L  P   + S+ +A  +  V EG+ + L C   G P P++ W      +G
Sbjct: 2012 EARKDFVVAVLVAPR--IRSSGVAREH-HVLEGQEVRLDCEADGQPPPDVAWLKDGSPLG 2068

Query: 234  NLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTI---- 289
              +  H+       GSL +  + + D+G   +CVA N  GED     + V   PTI    
Sbjct: 2069 QDMGPHL-RFYLDGGSLVLKGLRASDAG-AYTCVAHNPAGEDARLHTVNVLVPPTIKQGA 2126

Query: 290  ----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGC 345
                T +  P        P  V+G+P   + W  +G  L  S+   T +H + HT     
Sbjct: 2127 DGSGTLVSRPGELVTMVCP--VRGSPPIHVSWLKDGLPLPLSQR--TLLHGSGHT----- 2177

Query: 346  LQLDNPTHMNNGDYTLIAKNEYGKDEKQIS 375
            L++      + G +T +A +  G  ++  +
Sbjct: 2178 LRISKVQLADAGIFTCVAASPAGVADRNFT 2207



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 29/113 (25%), Positives = 46/113 (40%), Gaps = 2/113 (1%)

Query: 176  CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-DVGN 234
            CL E+   +    + +     P   +   ++TV  G  + L C   G+P P + W   G 
Sbjct: 3097 CLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ 3156

Query: 235  LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
             +       +   GSL + N+ + D+G    CVA NL+G       L V   P
Sbjct: 3157 PLRASRRLRTLPDGSLWLENVETGDAG-TYDCVAHNLLGSATARAFLVVRGEP 3208



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 47/187 (25%), Positives = 71/187 (37%), Gaps = 19/187 (10%)

Query: 197  PSANLAAPNLTVEEGKSITLSCSVAGDPVPNM-YWDVGNLVSKHMNETSHT---QGSLRI 252
            P+   +  NLT+       L C  +G P P + +W  G  +   + + ++      +L +
Sbjct: 2573 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLL 2632

Query: 253  TNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESP---TSDHHWCIPFTVKG 309
            T     DS  Q  CV  N VGE      +TVH  PTI   ++    T      +     G
Sbjct: 2633 TAPGPQDSA-QFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2691

Query: 310  NPKPALQWFYNGAILNE--SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEY 367
             P P + W   GA L    S Y              G L++     ++ G YT  A+N  
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGY---------RVSPSGALEIGQALPIHAGRYTCSARNSA 2742

Query: 368  GKDEKQI 374
            G   K +
Sbjct: 2743 GVAHKHV 2749



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 14/169 (8%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSHTQGSLRITNISSDDSGK 262
            + TV     + L+C   G P P + W      L ++         G+L I       +G+
Sbjct: 2674 DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR 2733

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLES---PTSDHHWCIPFTVKGNPKPALQWFY 319
              +C A N  G     V LTV  +P +  L S     ++    +P    G P+P + W  
Sbjct: 2734 Y-TCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK 2792

Query: 320  NGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
             G  LN +  + T++         G L++ + +  + G+Y  IAKN  G
Sbjct: 2793 EG--LNVATGVSTQVLP------GGQLRIAHASPEDAGNYLCIAKNSAG 2833



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 46/192 (23%), Positives = 75/192 (39%), Gaps = 19/192 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-HTQG-SLRITNISSDDSGKQ 263
            L    G+ +T+ C V G P  ++ W    L       T  H  G +LRI+ +   D+G  
Sbjct: 2132 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI- 2190

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQWF 318
             +CVA +  G    +  L V   P +  +E              +P   +G P P + W 
Sbjct: 2191 FTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWM 2250

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHF 378
             +G  L           ++   E    LQL+     ++G Y+ +A +E G+  +      
Sbjct: 2251 KDGEPL-----------LSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2299

Query: 379  MGWPGIDDGANP 390
            M  P I+D   P
Sbjct: 2300 MEPPHIEDSGQP 2311



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 41/194 (21%), Positives = 70/194 (36%), Gaps = 16/194 (8%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ- 263
            LTV EG   +LSC   G P P + W   G  +        H     R+  +      ++ 
Sbjct: 981  LTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 1040

Query: 264  -ISCVAENLVGEDQDSVNLTVHFAPTITFLESP------TSDHHWCIPFTVKGNPKPALQ 316
              +C   N+VG     + L VH  P I     P        D    +     G P P + 
Sbjct: 1041 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVT 1100

Query: 317  WFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISA 376
            W  +G  +         + + N  +    L ++     + G Y+ +A+N  G+ E++   
Sbjct: 1101 WERDGQPVGAE----LGLQLQNQGQ---SLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1153

Query: 377  HFMGWPGIDDGANP 390
              +  P +    +P
Sbjct: 1154 SVLVPPELIGDLDP 1167



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 56/226 (24%), Positives = 77/226 (34%), Gaps = 25/226 (11%)

Query: 161  TLQEAKSSPDTQDLY---CLNESSKNIPLANLQIPNCGLPSANLAAPN-----LTVEEGK 212
            TLQ  ++      +Y    LN + ++  L  L +    +P A   AP      + V  G 
Sbjct: 1801 TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL---VPPAFRQAPRGPQDAVLVRVGD 1857

Query: 213  SITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAEN 270
               LSC     P P + W  D   LV     +       L I      D G   SC   N
Sbjct: 1858 KAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY-SCKVSN 1916

Query: 271  LVGEDQDSVNLTVHFAPTI----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNE 326
            + GE   +  LTV   PT     T   S  +     +   V G P P + W  +   +  
Sbjct: 1917 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1976

Query: 327  SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
            S        V       G LQL        G YT +A+N   +  K
Sbjct: 1977 SA-------VHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 2015



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/195 (24%), Positives = 77/195 (39%), Gaps = 26/195 (13%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGK 262
            ++ V  G  + L C   G P+P + W  D   L+S+ + +      SL++  + + DSG 
Sbjct: 2224 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGP----SLQLEAVGAGDSG- 2278

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQW 317
              SCVA +  GE +    LTV   P I     PT           +    +G P+P + W
Sbjct: 2279 TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITW 2338

Query: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
              +G  L           + N++     L++      + G YT +A++  G  EK     
Sbjct: 2339 HKDGQALT---------RLENNSRATRVLRV-----RDAGLYTCLAESPAGAIEKSFRVR 2384

Query: 378  FMGWPGIDDGANPNY 392
                P I     P +
Sbjct: 2385 VQAPPNIVGPRGPRF 2399



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/174 (25%), Positives = 69/174 (39%), Gaps = 17/174 (9%)

Query: 208  VEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGS--LRITNISSDDSGKQIS 265
            + E     L C     P P++ W   +      +E S  QG   L+I  + ++++G+  S
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY-S 1629

Query: 266  CVAENLVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPF--TVKGNPKPALQWF 318
            C A N VGED     L V   P I       +E  T +    +       GNP P + W 
Sbjct: 1630 CKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 1689

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
             NG   + S     ++ V    +    LQ+      +   Y  +A+N+ G  EK
Sbjct: 1690 QNGLPFSPS----PRLQVLEDGQ---VLQVSTAEVADAASYMCVAENQAGSAEK 1736



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 42/176 (23%), Positives = 61/176 (34%), Gaps = 12/176 (6%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGK 262
            N++V   +S+ L C     P P + W  D   L  +     S  +  L++      D+G 
Sbjct: 888  NVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG- 946

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLESPT----SDHHWCIPFTVKGNPKPALQWF 318
              +C A N  G  +   NL V  AP     ES T      H   +    +G P P + W 
Sbjct: 947  HYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWR 1006

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
             +G  L         +       Y G  QL        G YT    N  G   + +
Sbjct: 1007 KDGQPLPGEGAGLQHVSAVGRLLYLGQAQL-----AQEGTYTCECSNVVGNSSQDL 1057



 Score = 34.7 bits (78), Expect = 0.23
 Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 5/115 (4%)

Query: 177  LNESSKNIPLANLQIPNCGL--PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-DVG 233
            L E+ KN  +  L  P+     P   +    +  +   ++TL C     P P + W   G
Sbjct: 1427 LGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDG 1486

Query: 234  NLVSKHMNETSHTQGSL-RITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
              V+         +G L +I      DSG+ + CVA N+ GED    N+ +   P
Sbjct: 1487 QPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYL-CVATNVAGEDDQDFNVLIQVPP 1540



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 32/134 (23%), Positives = 49/134 (36%), Gaps = 14/134 (10%)

Query: 199  ANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQG--SLRITNIS 256
            A L    +T     S++L C V   P P + W   +       E     G  +L++    
Sbjct: 1749 AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRAR 1808

Query: 257  SDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH---------HWCIPFTV 307
              DSG   +C A N  G DQ  V L+V   P   F ++P                +    
Sbjct: 1809 LSDSG-MYTCEALNAAGRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCET 1865

Query: 308  KGNPKPALQWFYNG 321
               P+P + W+ +G
Sbjct: 1866 DALPEPTVTWYKDG 1879


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 58/223 (26%), Positives = 91/223 (40%), Gaps = 18/223 (8%)

Query: 162  LQEAKSSPDTQDLY-CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSV 220
            L+ A +SP+    Y C+ ++S    +   ++     P      P+L+  EG    L C  
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2779

Query: 221  AGDPVPNMYWDV-GNLVSKHMNE-TSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDS 278
             G P PN+ WD  G  VS    + T    G L + N+   D+G   +C AEN VG  +  
Sbjct: 2780 RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAG-TYTCTAENAVGRARRR 2838

Query: 279  VNLTVHFAPTITFLESPTS----DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI 334
            V+LT+   P  T L    S    D  W +    +G+P P + W  N   + E        
Sbjct: 2839 VHLTILVLPVFTTLPGDRSLRLGDRLW-LRCAARGSPTPRIGWTVNDRPVTEG------- 2890

Query: 335  HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
               +  +    LQ    +  ++G Y   A+N  G+ +     H
Sbjct: 2891 --VSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVH 2931



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 50/164 (30%), Positives = 69/164 (42%), Gaps = 17/164 (10%)

Query: 211  GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQ-GSLRITNISSDDSGKQISCVAE 269
            G SI L C V GDPVP+++W    L  +  +     Q GSL I     DD+G+   C+AE
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGR-YQCLAE 3009

Query: 270  NLVGEDQDSVNLTVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYNGAIL 324
            N +G  +  V L +  AP   F   P      S     +     G P P ++W   G  L
Sbjct: 3010 NEMGVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPL 3067

Query: 325  NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
              S+ +         T   G L L+N    + G Y  +A N  G
Sbjct: 3068 RASRRL--------RTLPDGSLWLENVETGDAGTYDCVAHNLLG 3103



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 44/179 (24%), Positives = 76/179 (42%), Gaps = 18/179 (10%)

Query: 206 LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQG--SLRITNISSDDSGKQ 263
           + V E   + L C   G P PN+ W     +     +  +T+G   L++    S D+G  
Sbjct: 230 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAG-V 288

Query: 264 ISCVAENLVGEDQDSVNLTVHFAPTI------TFLESPTSDHHWCIPFTVKGNPKPALQW 317
            +C A N VG  + +  L V+  PTI       ++    +     +    +G+P P L W
Sbjct: 289 YTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSW 348

Query: 318 FYNGAILNESKYICTKIHVTNHTEYHG-CLQLDNPTHMNNGDYTLIAKNEYGKDEKQIS 375
            + G  + ES          +  E  G  L+L++P   ++G Y+ +A +  G+   Q S
Sbjct: 349 HHEGLPVAESN--------ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYS 399



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 49/166 (29%), Positives = 71/166 (42%), Gaps = 15/166 (9%)

Query: 214 ITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQGSLRITNISS---DDSGKQISCVAE 269
           + L+C+  G P P + W   GN VS             R+  ++S    DSG+  SCVA 
Sbjct: 713 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY-SCVAV 771

Query: 270 NLVGEDQDSVNLTVHFAPTITFLE---SPTSDHHWCIPFTVKGNPKPALQWFYNGAILNE 326
           + VGED+  V L VH  P+I   E   S  ++    +       P P L W+ +G  L  
Sbjct: 772 SAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 831

Query: 327 SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
                  +H++        LQ+D     + G YT  A N+ G  EK
Sbjct: 832 R----PGVHLSAD---KALLQVDRADVWDAGHYTCEALNQAGHSEK 870



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 52/224 (23%), Positives = 93/224 (41%), Gaps = 19/224 (8%)

Query: 164  EAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGD 223
            +A S+ D+ D  C   ++        ++    +P+     P + V   ++  L C   G 
Sbjct: 2358 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 2417

Query: 224  PVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNL 281
            P P + W  D   L  +        +GSLRI  + + D+G  + C+A N  G D+   +L
Sbjct: 2418 PAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYL-CLASNSAGSDRQGRDL 2476

Query: 282  TVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYNGAILN-ESKYICTKIH 335
             V   P I    SP     T+     +P    G+PKP + W+ +G  L+   +    ++ 
Sbjct: 2477 RVLEPPAIA--PSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL 2534

Query: 336  VTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK--QISAH 377
             +N       L L  P   ++  +  +  NE G+  +  Q++ H
Sbjct: 2535 PSN------ALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVH 2572



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 52/191 (27%), Positives = 77/191 (40%), Gaps = 22/191 (11%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263
            + V +G++  L C+V G P P + W  D   L     +  S     L++   +   +G  
Sbjct: 1173 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAG-H 1231

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGN----------PKP 313
             SC+A N VGE      L+V  APTI      ++D    +  TV             P P
Sbjct: 1232 YSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEE--VTVTVNNPISLICEALAFPSP 1289

Query: 314  ALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQ 373
             + W  +GA    S+     I +   T  HG LQ+ N    + G YT +  NE G+  K 
Sbjct: 1290 NITWMKDGAPFEASR----NIQLLPGT--HG-LQILNAQKEDAGQYTCVVTNELGEAVKN 1342

Query: 374  ISAHFMGWPGI 384
                 +  P I
Sbjct: 1343 YHVEVLIPPSI 1353



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 54/202 (26%), Positives = 80/202 (39%), Gaps = 17/202 (8%)

Query: 179 ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL-VS 237
           ES + + L  L  PN      N A     V E  S+TL C  +G P P++ W  G+  VS
Sbjct: 591 ESKREVALKVLVPPNIEPGPVNKA-----VLENASVTLECLASGVPPPDVSWFKGHQPVS 645

Query: 238 KHMNETSHTQGS-LRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPT 296
             M  T    G  LRI      D+G    CVA N+ G  +    L V+  P IT   S  
Sbjct: 646 SWMGVTVSVDGRVLRIEQAQLSDAG-SYRCVASNVAGSTELRYGLRVNVPPRITLPPSLP 704

Query: 297 SDHHWCIPF----TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPT 352
                  P        G P P L W  +G  ++ +     ++           L L +  
Sbjct: 705 GPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV-----LTLASAR 759

Query: 353 HMNNGDYTLIAKNEYGKDEKQI 374
             ++G Y+ +A +  G+D + +
Sbjct: 760 ASDSGRYSCVAVSAVGEDRQDV 781



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 51/171 (29%), Positives = 66/171 (38%), Gaps = 18/171 (10%)

Query: 211 GKSITLSCSVAGDPVPNMYWDVGNLV----SKHMNETSHTQGSLRITNISSDDSGKQISC 266
           G  + L C  +G P P + W            H+      Q  LRIT     D G+   C
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ-VLRITGSHVGDEGR-YQC 198

Query: 267 VAENLVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNG 321
           VA +  G+      L VH  PTI     T   +   DH   +    +G P P + WF +G
Sbjct: 199 VAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDG 258

Query: 322 AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
           A+L  S    TK+  T        LQL      + G YT  A N  G  EK
Sbjct: 259 ALLPTS----TKVVYTRGGRQ---LQLGRAQSSDAGVYTCKASNAVGAAEK 302



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 29/202 (14%)

Query: 206 LTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQG-SLRITNISSDDSGKQ 263
           +T   G+ + L C  +G PVP + W   G    +       +QG +L I ++  D SG  
Sbjct: 417 VTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG-L 475

Query: 264 ISCVAENLVGEDQDSVNLTVH--FAPTITFLESPTSDHHW-----------CIPFTVKG- 309
            +C A N  G     V ++VH  +AP +  LE P   +HW           C P   +G 
Sbjct: 476 FACQATNEAGTAGAEVEVSVHGEWAPGV--LEVPIGQYHWGXEHHSSFPAACDPPVHRGW 533

Query: 310 --NPKPAL--QWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
             +PKP L   W   G++  E   I     +         LQ++     + G YT  A N
Sbjct: 534 GAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPP------LQIEKVDLRDEGIYTCAATN 587

Query: 366 EYGKDEKQISAHFMGWPGIDDG 387
             G+ +++++   +  P I+ G
Sbjct: 588 LAGESKREVALKVLVPPNIEPG 609



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 44/187 (23%), Positives = 69/187 (36%), Gaps = 18/187 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQIS 265
            L++  G  + L C   G P PN+ W         +   S     LR+      D+G   +
Sbjct: 2223 LSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR-----DAG-LYT 2276

Query: 266  CVAENLVGEDQDSVNLTVHFAPTITFLESP-----TSDHHWCIPFTVKGNPKPALQWFYN 320
            C+AE+  G  + S  + V   P I     P      +     +  +V+  P P + W  +
Sbjct: 2277 CLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRD 2336

Query: 321  GAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMG 380
            G +L E  +       T   E    LQL   +  ++GDY+  A+N  G            
Sbjct: 2337 GIVLQEDAH-------TQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT 2389

Query: 381  WPGIDDG 387
             P I  G
Sbjct: 2390 VPTIRSG 2396



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 15/169 (8%)

Query: 211  GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAEN 270
            G  + L C+  G P P + W V +              +L+   +S +DSG  + C AEN
Sbjct: 2861 GDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYV-CWAEN 2919

Query: 271  LVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILN 325
             VG  Q    + V  AP +     ++L  P       +   V+G+P P + W  +G  L 
Sbjct: 2920 RVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQ-LDCVVRGDPVPDIHWIKDGLPLR 2978

Query: 326  ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
             S           H   +G L +      + G Y  +A+NE G  +K +
Sbjct: 2979 GSHL--------RHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVV 3019



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 48/189 (25%), Positives = 83/189 (43%), Gaps = 21/189 (11%)

Query: 208  VEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNETSHTQG-SLRITNISSDDSGKQIS 265
            V++G + TL C+  G P P + W+  G  V   +      QG SL +    +  +G+  S
Sbjct: 989  VQDGVA-TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRY-S 1046

Query: 266  CVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCI--PFTV----KGNPKPALQWFY 319
            CVAENL G  +    L+V   P +     P ++    +  P T+     G P PA++WF 
Sbjct: 1047 CVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR 1106

Query: 320  NGAILN--ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
                ++  E  Y+     +         L++      ++G Y+ +A NE G+  +  S  
Sbjct: 1107 GEEPVSPGEDTYLLAGGWM---------LKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 1157

Query: 378  FMGWPGIDD 386
             +  P I++
Sbjct: 1158 VLVPPSIEN 1166



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 54/196 (27%), Positives = 77/196 (39%), Gaps = 25/196 (12%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGS--LRITNISSDDSGK 262
            N+T      +TL C   G P P + W  G        +T    G   L++T     DSG 
Sbjct: 1079 NITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSG- 1137

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPT---------ITFLESPTSDHHWCIPFTVKGNPKP 313
              SC+A N  GE + + ++ V   P+         I  L+  T+ H  C    V G+P+P
Sbjct: 1138 LYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTA-HLMC---NVTGHPQP 1193

Query: 314  ALQWFYNGAILNESKYICTKIHVTNHTEYHG-CLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
             L WF +G  L             +H    G  LQ+      + G Y+ IA N  G+  K
Sbjct: 1194 KLTWFKDGRPLARGD--------AHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTK 1245

Query: 373  QISAHFMGWPGIDDGA 388
                  +  P I  GA
Sbjct: 1246 HFQLSVLLAPTILGGA 1261



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 45/187 (24%), Positives = 77/187 (41%), Gaps = 15/187 (8%)

Query: 211  GKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA 268
            G  + L+C V+G P P + W  D   + S  ++      G L+++ +    +G   +CVA
Sbjct: 1857 GSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAG-TYTCVA 1915

Query: 269  ENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWC------IPFTVKGNPKPALQWFYNGA 322
            EN   E +    + V  AP I        +HH        +     G P P + W  +G+
Sbjct: 1916 ENTQAEARKDFVVAVLVAPRIR-SSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGS 1974

Query: 323  ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWP 382
             L +      + ++       G L L      + G YT +A N  G+D +  + + +  P
Sbjct: 1975 PLGQDMGPHLRFYLDG-----GSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP 2029

Query: 383  GIDDGAN 389
             I  GA+
Sbjct: 2030 TIKQGAD 2036



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 20/178 (11%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNL---VSKHMNETSHTQGSLRITNISSDDSGK 262
            +TV    +++L C   G+PVP + W    L    S  +      Q  L+++     D+  
Sbjct: 1573 VTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ-VLQVSTAEVADAAS 1631

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLE----SPTSDHHWCIPFTVKGNPKPALQWF 318
             + CVAEN  G  +    L V   P I  L+    +   +    +P  V  +P P + W+
Sbjct: 1632 YM-CVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWY 1690

Query: 319  YNGAILN--ESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
             +   L+  E  ++    H          LQL      ++G YT  A N  G+D+K +
Sbjct: 1691 KDSQALSLGEEVFLLPGTHT---------LQLGRARLSDSGMYTCEALNAAGRDQKLV 1739



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 45/182 (24%), Positives = 68/182 (37%), Gaps = 15/182 (8%)

Query: 211 GKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-HTQGSLRITNISSDDSGKQISCVAE 269
           G+ + L C   G P P + W    L     NE+   T GS+       + S    SCVA 
Sbjct: 329 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 388

Query: 270 NLVGEDQDSVNLTVHFAPTITFLE-----SPTSDHHWCIPFTVKGNPKPALQWFYNGAIL 324
           +  GE     ++ V   P +   E     +        +P    G+P P +QW  NG   
Sbjct: 389 SPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPA 448

Query: 325 NESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK--DEKQISAHFMGWP 382
            E   +      T        L +D+    ++G +   A NE G    E ++S H    P
Sbjct: 449 EELAGVQVASQGTT-------LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAP 501

Query: 383 GI 384
           G+
Sbjct: 502 GV 503



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 56/253 (22%), Positives = 101/253 (39%), Gaps = 41/253 (16%)

Query: 147  GNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLN---ESSKNIPLANLQIPNCGLPSANLAA 203
            G+    S D + ++ LQ   SS         N   E +K+  L+ L  P     + + A 
Sbjct: 1207 GDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSAD 1266

Query: 204  PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL---VSKHMNETSHTQGSLRITNISSDDS 260
              +TV     I+L C     P PN+ W         S+++     T G L+I N   +D+
Sbjct: 1267 EEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDA 1325

Query: 261  GKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSD------------------HHWC 302
            G Q +CV  N +GE   + ++ V   P+I+  + P ++                    W 
Sbjct: 1326 G-QYTCVVTNELGEAVKNYHVEVLIPPSIS-KDDPLAEVGVKEVKTKVNSTLTLECESWA 1383

Query: 303  IPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLI 362
            +       P P ++W+ +G  +  S    +++ V         LQ+      ++G Y  +
Sbjct: 1384 V-------PPPTIRWYKDGQPVTPS----SRLQVLGEGR---LLQIQPTQVSDSGRYLCV 1429

Query: 363  AKNEYGKDEKQIS 375
            A N  G+D++  +
Sbjct: 1430 ATNVAGEDDQDFN 1442



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 53/210 (25%), Positives = 90/210 (42%), Gaps = 27/210 (12%)

Query: 179  ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-----DVG 233
            E+ K+  +A L  P   + S+ +A  +  V EG+ + L C   G P P++ W      +G
Sbjct: 1921 EARKDFVVAVLVAPR--IRSSGVAREH-HVLEGQEVRLDCEADGQPPPDVAWLKDGSPLG 1977

Query: 234  NLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTI---- 289
              +  H+       GSL +  + + D+G   +CVA N  GED     + V   PTI    
Sbjct: 1978 QDMGPHL-RFYLDGGSLVLKGLRASDAG-AYTCVAHNPAGEDARLHTVNVLVPPTIKQGA 2035

Query: 290  ----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGC 345
                T +  P        P  V+G+P   + W  +G  L  S+   T +H + HT     
Sbjct: 2036 DGSGTLVSRPGELVTMVCP--VRGSPPIHVSWLKDGLPLPLSQR--TLLHGSGHT----- 2086

Query: 346  LQLDNPTHMNNGDYTLIAKNEYGKDEKQIS 375
            L++      + G +T +A +  G  ++  +
Sbjct: 2087 LRISKVQLADAGIFTCVAASPAGVADRNFT 2116



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 29/113 (25%), Positives = 46/113 (40%), Gaps = 2/113 (1%)

Query: 176  CLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-DVGN 234
            CL E+   +    + +     P   +   ++TV  G  + L C   G+P P + W   G 
Sbjct: 3006 CLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ 3065

Query: 235  LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
             +       +   GSL + N+ + D+G    CVA NL+G       L V   P
Sbjct: 3066 PLRASRRLRTLPDGSLWLENVETGDAG-TYDCVAHNLLGSATARAFLVVRGEP 3117



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 47/187 (25%), Positives = 71/187 (37%), Gaps = 19/187 (10%)

Query: 197  PSANLAAPNLTVEEGKSITLSCSVAGDPVPNM-YWDVGNLVSKHMNETSHT---QGSLRI 252
            P+   +  NLT+       L C  +G P P + +W  G  +   + + ++      +L +
Sbjct: 2482 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLL 2541

Query: 253  TNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESP---TSDHHWCIPFTVKG 309
            T     DS  Q  CV  N VGE      +TVH  PTI   ++    T      +     G
Sbjct: 2542 TAPGPQDSA-QFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2600

Query: 310  NPKPALQWFYNGAILNE--SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEY 367
             P P + W   GA L    S Y              G L++     ++ G YT  A+N  
Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGY---------RVSPSGALEIGQALPIHAGRYTCSARNSA 2651

Query: 368  GKDEKQI 374
            G   K +
Sbjct: 2652 GVAHKHV 2658



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 14/169 (8%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSHTQGSLRITNISSDDSGK 262
            + TV     + L+C   G P P + W      L ++         G+L I       +G+
Sbjct: 2583 DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGR 2642

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLES---PTSDHHWCIPFTVKGNPKPALQWFY 319
              +C A N  G     V LTV  +P +  L S     ++    +P    G P+P + W  
Sbjct: 2643 Y-TCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK 2701

Query: 320  NGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
             G  LN +  + T++         G L++ + +  + G+Y  IAKN  G
Sbjct: 2702 EG--LNVATGVSTQVLP------GGQLRIAHASPEDAGNYLCIAKNSAG 2742



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 46/192 (23%), Positives = 75/192 (39%), Gaps = 19/192 (9%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-HTQG-SLRITNISSDDSGKQ 263
            L    G+ +T+ C V G P  ++ W    L       T  H  G +LRI+ +   D+G  
Sbjct: 2041 LVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI- 2099

Query: 264  ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQWF 318
             +CVA +  G    +  L V   P +  +E              +P   +G P P + W 
Sbjct: 2100 FTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWM 2159

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHF 378
             +G  L           ++   E    LQL+     ++G Y+ +A +E G+  +      
Sbjct: 2160 KDGEPL-----------LSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV 2208

Query: 379  MGWPGIDDGANP 390
            M  P I+D   P
Sbjct: 2209 MEPPHIEDSGQP 2220



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 41/194 (21%), Positives = 69/194 (35%), Gaps = 16/194 (8%)

Query: 206  LTVEEGKSITLSCSVAGDPVPNMYW-DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ- 263
            LTV EG    LSC   G P P + W   G  +        H     R+  +      ++ 
Sbjct: 890  LTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 949

Query: 264  -ISCVAENLVGEDQDSVNLTVHFAPTITFLESP------TSDHHWCIPFTVKGNPKPALQ 316
              +C   N+VG     + L VH  P I     P        D    +     G P P + 
Sbjct: 950  TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVT 1009

Query: 317  WFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISA 376
            W  +G  +         + + N  +    L ++     + G Y+ +A+N  G+ E++   
Sbjct: 1010 WERDGQPVGAE----LGLQLQNQGQ---SLHVERAQAAHTGRYSCVAENLAGRAERKFEL 1062

Query: 377  HFMGWPGIDDGANP 390
              +  P +    +P
Sbjct: 1063 SVLVPPELIGDLDP 1076



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 56/226 (24%), Positives = 77/226 (34%), Gaps = 25/226 (11%)

Query: 161  TLQEAKSSPDTQDLY---CLNESSKNIPLANLQIPNCGLPSANLAAPN-----LTVEEGK 212
            TLQ  ++      +Y    LN + ++  L  L +    +P A   AP      + V  G 
Sbjct: 1710 TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL---VPPAFRQAPRGPQDAVLVRVGD 1766

Query: 213  SITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAEN 270
               LSC     P P + W  D   LV     +       L I      D G   SC   N
Sbjct: 1767 KAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLY-SCKVSN 1825

Query: 271  LVGEDQDSVNLTVHFAPTI----TFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNE 326
            + GE   +  LTV   PT     T   S  +     +   V G P P + W  +   +  
Sbjct: 1826 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1885

Query: 327  SKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
            S        V       G LQL        G YT +A+N   +  K
Sbjct: 1886 SA-------VHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 1924



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 47/195 (24%), Positives = 77/195 (39%), Gaps = 26/195 (13%)

Query: 205  NLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGK 262
            ++ V  G  + L C   G P+P + W  D   L+S+ + +      SL++  + + DSG 
Sbjct: 2133 DVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGP----SLQLEAVGAGDSG- 2187

Query: 263  QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKGNPKPALQW 317
              SCVA +  GE +    LTV   P I     PT           +    +G P+P + W
Sbjct: 2188 TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITW 2247

Query: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
              +G  L           + N++     L++      + G YT +A++  G  EK     
Sbjct: 2248 HKDGQALT---------RLENNSRATRVLRV-----RDAGLYTCLAESPAGAIEKSFRVR 2293

Query: 378  FMGWPGIDDGANPNY 392
                P I     P +
Sbjct: 2294 VQAPPNIVGPRGPRF 2308



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/174 (25%), Positives = 69/174 (39%), Gaps = 17/174 (9%)

Query: 208  VEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGS--LRITNISSDDSGKQIS 265
            + E     L C     P P++ W   +      +E S  QG   L+I  + ++++G+  S
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY-S 1538

Query: 266  CVAENLVGEDQDSVNLTVHFAPTI-----TFLESPTSDHHWCIPF--TVKGNPKPALQWF 318
            C A N VGED     L V   P I       +E  T +    +       GNP P + W 
Sbjct: 1539 CKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWL 1598

Query: 319  YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEK 372
             NG   + S     ++ V    +    LQ+      +   Y  +A+N+ G  EK
Sbjct: 1599 QNGLPFSPS----PRLQVLEDGQ---VLQVSTAEVADAASYMCVAENQAGSAEK 1645



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 42/176 (23%), Positives = 61/176 (34%), Gaps = 12/176 (6%)

Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNETSHTQGSLRITNISSDDSGK 262
           N++V   +S+ L C     P P + W  D   L  +     S  +  L++      D+G 
Sbjct: 797 NVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG- 855

Query: 263 QISCVAENLVGEDQDSVNLTVHFAPTITFLESPT----SDHHWCIPFTVKGNPKPALQWF 318
             +C A N  G  +   NL V  AP     ES T      H   +    +G P P + W 
Sbjct: 856 HYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWR 915

Query: 319 YNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI 374
            +G  L         +       Y G  QL        G YT    N  G   + +
Sbjct: 916 KDGQPLPGEGAGLQHVSAVGRLLYLGQAQL-----AQEGTYTCECSNVVGNSSQDL 966



 Score = 36.2 bits (82), Expect = 0.081
 Identities = 31/115 (26%), Positives = 48/115 (41%), Gaps = 5/115 (4%)

Query: 177  LNESSKNIPLANLQIPNCGL--PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW-DVG 233
            L E+ KN  +  L  P+     P A +    +  +   ++TL C     P P + W   G
Sbjct: 1336 LGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDG 1395

Query: 234  NLVSKHMNETSHTQGSL-RITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP 287
              V+         +G L +I      DSG+ + CVA N+ GED    N+ +   P
Sbjct: 1396 QPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYL-CVATNVAGEDDQDFNVLIQVPP 1449



 Score = 32.7 bits (73), Expect = 0.89
 Identities = 31/104 (29%), Positives = 40/104 (38%), Gaps = 22/104 (21%)

Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYW------------------DVG-NLVSKHMNETSH 245
           N++   G+S+TL C   G PVP + W                  D+G   V  H      
Sbjct: 27  NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGH--RLLD 84

Query: 246 TQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTI 289
              SL    I   DSG   SC AEN  G  Q   +L V   P++
Sbjct: 85  EGQSLHFPRIQEGDSGLY-SCRAENQAGTAQRDFHLLVLTPPSV 127



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 32/134 (23%), Positives = 49/134 (36%), Gaps = 14/134 (10%)

Query: 199  ANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQG--SLRITNIS 256
            A L    +T     S++L C V   P P + W   +       E     G  +L++    
Sbjct: 1658 AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRAR 1717

Query: 257  SDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH---------HWCIPFTV 307
              DSG   +C A N  G DQ  V L+V   P   F ++P                +    
Sbjct: 1718 LSDSG-MYTCEALNAAGRDQKLVQLSVLVPP--AFRQAPRGPQDAVLVRVGDKAVLSCET 1774

Query: 308  KGNPKPALQWFYNG 321
               P+P + W+ +G
Sbjct: 1775 DALPEPTVTWYKDG 1788


>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 53/230 (23%), Positives = 101/230 (43%), Gaps = 14/230 (6%)

Query: 67  NITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG-LKFVAHKAFLKNSNLQHINFTRN 125
           ++ E+ I N   L  I+   V+    LR +   ++  L ++   AF +   L+ +    N
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344

Query: 126 KLTSLSRKHFRHL-DLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLN------ 178
            L++L       L +L E+ +  NP  C C I W+   +      +   L+C++      
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQG 404

Query: 179 ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGN---L 235
           ++ + +   ++      L +      NL VE G  ++  C    +P P +YW   +   L
Sbjct: 405 QNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKL 464

Query: 236 VSKHMNET--SHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV 283
           +   + +    H++G+L I  ++  + G   +C+A NLVG D  SV + V
Sbjct: 465 LPNTLTDKFYVHSEGTLDINGVTPKEGG-LYTCIATNLVGADLKSVMIKV 513



 Score = 33.9 bits (76), Expect = 0.40
 Identities = 74/326 (22%), Positives = 123/326 (37%), Gaps = 47/326 (14%)

Query: 67  NITEIFIANQKRLEIINEDDVEAYVGLRNLTIV---DSGLKFVAHKAFLKNSNLQHINFT 123
           N+  + IA     EI +     A VGL NL  +   D+ L  V H A  K  NL+ ++  
Sbjct: 213 NLRSLVIAGINLTEIPDN----ALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268

Query: 124 RNKLTSLSRKHFRH-LDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSK 182
           +N +  + R  F + L L EL +   P   S D + +  L      PD + +    E++ 
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNL------PDLRKI----EATN 318

Query: 183 NIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAG--DPVPNMYWDVGNLVSKHM 240
           N  L+ +       P+A    P L      S  LS    G  + +PN+       +S H 
Sbjct: 319 NPRLSYIH------PNAFFRLPKLESLMLNSNALSALYHGTIESLPNL-----KEISIHS 367

Query: 241 N----ETSHTQGSLRITNISSDDSGKQISCVAENLVGED------QDSVNLTVHFAPTIT 290
           N    +      ++  TNI   +             G++      +D + + +      +
Sbjct: 368 NPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPES 427

Query: 291 FLESPTSDHHWCIPFTVK--GNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQL 348
           F  +   +    + F  +    P+P + W            +  K +V  H+E  G L +
Sbjct: 428 FPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYV--HSE--GTLDI 483

Query: 349 DNPTHMNNGDYTLIAKNEYGKDEKQI 374
           +  T    G YT IA N  G D K +
Sbjct: 484 NGVTPKEGGLYTCIATNLVGADLKSV 509


>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 53/230 (23%), Positives = 101/230 (43%), Gaps = 14/230 (6%)

Query: 67  NITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG-LKFVAHKAFLKNSNLQHINFTRN 125
           ++ E+ I N   L  I+   V+    LR +   ++  L ++   AF +   L+ +    N
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344

Query: 126 KLTSLSRKHFRHL-DLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLN------ 178
            L++L       L +L E+ +  NP  C C I W+   +      +   L+C++      
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQG 404

Query: 179 ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGN---L 235
           ++ + +   ++      L +      NL VE G  ++  C    +P P +YW   +   L
Sbjct: 405 QNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKL 464

Query: 236 VSKHMNET--SHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV 283
           +   + +    H++G+L I  ++  + G   +C+A NLVG D  SV + V
Sbjct: 465 LPNTLTDKFYVHSEGTLDINGVTPKEGG-LYTCIATNLVGADLKSVMIKV 513



 Score = 33.9 bits (76), Expect = 0.40
 Identities = 74/326 (22%), Positives = 123/326 (37%), Gaps = 47/326 (14%)

Query: 67  NITEIFIANQKRLEIINEDDVEAYVGLRNLTIV---DSGLKFVAHKAFLKNSNLQHINFT 123
           N+  + IA     EI +     A VGL NL  +   D+ L  V H A  K  NL+ ++  
Sbjct: 213 NLRSLVIAGINLTEIPDN----ALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268

Query: 124 RNKLTSLSRKHFRH-LDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSK 182
           +N +  + R  F + L L EL +   P   S D + +  L      PD + +    E++ 
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNL------PDLRKI----EATN 318

Query: 183 NIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAG--DPVPNMYWDVGNLVSKHM 240
           N  L+ +       P+A    P L      S  LS    G  + +PN+       +S H 
Sbjct: 319 NPRLSYIH------PNAFFRLPKLESLMLNSNALSALYHGTIESLPNL-----KEISIHS 367

Query: 241 N----ETSHTQGSLRITNISSDDSGKQISCVAENLVGED------QDSVNLTVHFAPTIT 290
           N    +      ++  TNI   +             G++      +D + + +      +
Sbjct: 368 NPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPES 427

Query: 291 FLESPTSDHHWCIPFTVK--GNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQL 348
           F  +   +    + F  +    P+P + W            +  K +V  H+E  G L +
Sbjct: 428 FPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYV--HSE--GTLDI 483

Query: 349 DNPTHMNNGDYTLIAKNEYGKDEKQI 374
           +  T    G YT IA N  G D K +
Sbjct: 484 NGVTPKEGGLYTCIATNLVGADLKSV 509


>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 53/230 (23%), Positives = 101/230 (43%), Gaps = 14/230 (6%)

Query: 67  NITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSG-LKFVAHKAFLKNSNLQHINFTRN 125
           ++ E+ I N   L  I+   V+    LR +   ++  L ++   AF +   L+ +    N
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344

Query: 126 KLTSLSRKHFRHL-DLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLN------ 178
            L++L       L +L E+ +  NP  C C I W+   +      +   L+C++      
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQG 404

Query: 179 ESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGN---L 235
           ++ + +   ++      L +      NL VE G  ++  C    +P P +YW   +   L
Sbjct: 405 QNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKL 464

Query: 236 VSKHMNET--SHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV 283
           +   + +    H++G+L I  ++  + G   +C+A NLVG D  SV + V
Sbjct: 465 LPNTLTDKFYVHSEGTLDINGVTPKEGG-LYTCIATNLVGADLKSVMIKV 513



 Score = 33.9 bits (76), Expect = 0.40
 Identities = 74/326 (22%), Positives = 123/326 (37%), Gaps = 47/326 (14%)

Query: 67  NITEIFIANQKRLEIINEDDVEAYVGLRNLTIV---DSGLKFVAHKAFLKNSNLQHINFT 123
           N+  + IA     EI +     A VGL NL  +   D+ L  V H A  K  NL+ ++  
Sbjct: 213 NLRSLVIAGINLTEIPDN----ALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268

Query: 124 RNKLTSLSRKHFRH-LDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSK 182
           +N +  + R  F + L L EL +   P   S D + +  L      PD + +    E++ 
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNL------PDLRKI----EATN 318

Query: 183 NIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAG--DPVPNMYWDVGNLVSKHM 240
           N  L+ +       P+A    P L      S  LS    G  + +PN+       +S H 
Sbjct: 319 NPRLSYIH------PNAFFRLPKLESLMLNSNALSALYHGTIESLPNL-----KEISIHS 367

Query: 241 N----ETSHTQGSLRITNISSDDSGKQISCVAENLVGED------QDSVNLTVHFAPTIT 290
           N    +      ++  TNI   +             G++      +D + + +      +
Sbjct: 368 NPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPES 427

Query: 291 FLESPTSDHHWCIPFTVK--GNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQL 348
           F  +   +    + F  +    P+P + W            +  K +V  H+E  G L +
Sbjct: 428 FPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYV--HSE--GTLDI 483

Query: 349 DNPTHMNNGDYTLIAKNEYGKDEKQI 374
           +  T    G YT IA N  G D K +
Sbjct: 484 NGVTPKEGGLYTCIATNLVGADLKSV 509


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 54/221 (24%), Positives = 93/221 (42%), Gaps = 16/221 (7%)

Query: 196 LPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDV-GNLVSKHMNETSHTQGSLRITN 254
           LP   +   +  V EG+++   C   G+P P + W   G+ +S        + G+LRI+ 
Sbjct: 432 LPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISG 491

Query: 255 ISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS-----DHHWCIPFTVKG 309
           ++  D G Q  C A N++G  +   +LTV    T  F   P+        +  +P + +G
Sbjct: 492 VALHDQG-QYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQG 550

Query: 310 NPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
            P+PA+ W  +G  + ES     K H++      G L +++    + G Y  +A+N  G 
Sbjct: 551 EPEPAITWNKDGVQVTES----GKFHISP----EGFLTINDVGPADAGRYECVARNTIGS 602

Query: 370 DEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDT 410
               +    +  P +    +P     I E   T    I  T
Sbjct: 603 ASVSMVLS-VNVPDVSRNGDPFVATSIVEAIATVDRAINST 642



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 65/319 (20%), Positives = 123/319 (38%), Gaps = 27/319 (8%)

Query: 64  DPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFT 123
           D EN+  +++   + ++ I+    +    L  L +  + ++ +   +F     L+ +   
Sbjct: 108 DLENLKYLYLYKNE-IQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLH 166

Query: 124 RNKLTSLSRKHFRHLD-LSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNE--- 179
            N++T L    F HL+ +  L L  N   C C+I+W+  L +  +         + E   
Sbjct: 167 NNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPR 226

Query: 180 --SSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVS 237
               +++     +  NC  P       +  V  G ++  +C   G+P P + W + N   
Sbjct: 227 RIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIW-LRNNNE 285

Query: 238 KHMNETSH----TQGSLRITNISSDDSGKQISCVAENLVGE-DQDSVNLTVHFAPT-ITF 291
             M   S       G+L I N    D G    C+A+N+ GE     V L    +P   TF
Sbjct: 286 LSMKTDSRLNLLDDGTLMIQNTQETDQG-IYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344

Query: 292 LESPTS-----DHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCL 346
           +  P +          +  +  G+P P + W            +  ++++T      G L
Sbjct: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGD---RTPLPVDPRVNITP----SGGL 397

Query: 347 QLDNPTHMNNGDYTLIAKN 365
            + N    ++G+Y   A N
Sbjct: 398 YIQNVVQGDSGEYACSATN 416



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 52/199 (26%), Positives = 79/199 (39%), Gaps = 28/199 (14%)

Query: 197 PSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNL----VSKHMNETSHTQGSLRI 252
           P+  +   N  V  G+S+TL CS  G P P + W  G+     V   +N T    G L I
Sbjct: 342 PTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNIT--PSGGLYI 399

Query: 253 TNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTIT-------FLESPTSDHHWCIPF 305
            N+   DSG + +C A N +     +  + V   P  T        +E  T D       
Sbjct: 400 QNVVQGDSG-EYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVD----FQC 454

Query: 306 TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
             KGNP P + W   G+ L+  +      H+   +   G L++      + G Y   A N
Sbjct: 455 EAKGNPPPVIAWTKGGSQLSVDRR-----HLVLSS---GTLRISGVALHDQGQYECQAVN 506

Query: 366 EYGKDEKQISAHFMGWPGI 384
             G   +++ AH    P +
Sbjct: 507 IIG--SQKVVAHLTVQPRV 523


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,882,149
Number of Sequences: 37866
Number of extensions: 1066813
Number of successful extensions: 5023
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 240
Number of HSP's that attempted gapping in prelim test: 2791
Number of HSP's gapped (non-prelim): 1726
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press