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Search of human proteins with 65506442
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform a precursor [Homo sapiens]
(728 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide ... 1437 0.0
gi|189095269 propionyl-Coenzyme A carboxylase, alpha polypeptide... 1368 0.0
gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) pr... 469 e-132
gi|106049528 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|106049295 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|106049292 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ... 248 2e-65
gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo ... 248 2e-65
gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo ... 248 2e-65
gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ... 248 2e-65
gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo ... 248 2e-65
gi|134142062 acetyl-Coenzyme A carboxylase beta [Homo sapiens] 246 7e-65
gi|18105007 carbamoylphosphate synthetase 2/aspartate transcarba... 63 1e-09
gi|169790915 carbamoyl-phosphate synthetase 1 isoform a precurso... 56 1e-07
gi|21361331 carbamoyl-phosphate synthetase 1 isoform b precursor... 56 1e-07
gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo sa... 54 4e-07
gi|110671329 dihydrolipoamide branched chain transacylase precur... 33 0.94
gi|212549738 anaphase-promoting complex subunit 7 isoform b [Hom... 32 1.6
gi|212549736 anaphase-promoting complex subunit 7 isoform a [Hom... 32 1.6
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 30 6.1
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 30 6.1
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 30 6.1
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 30 6.1
gi|28416899 phosphoribosylglycinamide formyltransferase, phospho... 30 6.1
gi|4503915 phosphoribosylglycinamide formyltransferase, phosphor... 30 6.1
gi|209869995 phosphoribosylglycinamide formyltransferase, phosph... 30 6.1
gi|209869993 phosphoribosylglycinamide formyltransferase, phosph... 30 6.1
gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens] 30 6.1
gi|4505941 DNA directed RNA polymerase II polypeptide B [Homo sa... 30 7.9
gi|134133279 SP140 nuclear body protein-like [Homo sapiens] 30 7.9
>gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform a precursor [Homo sapiens]
Length = 728
Score = 1437 bits (3719), Expect = 0.0
Identities = 728/728 (100%), Positives = 728/728 (100%)
Query: 1 MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNE 60
MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNE
Sbjct: 1 MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNE 60
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS 120
KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS
Sbjct: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS 120
Query: 121 YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES 180
YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES
Sbjct: 121 YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES 180
Query: 181 KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 240
KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD
Sbjct: 181 KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 240
Query: 241 GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV 300
GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV
Sbjct: 241 GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV 300
Query: 301 EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV 360
EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV
Sbjct: 301 EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV 360
Query: 361 TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY 420
TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY
Sbjct: 361 TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY 420
Query: 421 QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH 480
QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH
Sbjct: 421 QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH 480
Query: 481 NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA 540
NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA
Sbjct: 481 NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA 540
Query: 541 QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS 600
QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS
Sbjct: 541 QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS 600
Query: 601 PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS 660
PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS
Sbjct: 601 PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS 660
Query: 661 VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE 720
VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE
Sbjct: 661 VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE 720
Query: 721 GDLLVELE 728
GDLLVELE
Sbjct: 721 GDLLVELE 728
>gi|189095269 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform b [Homo sapiens]
Length = 702
Score = 1368 bits (3541), Expect = 0.0
Identities = 702/728 (96%), Positives = 702/728 (96%), Gaps = 26/728 (3%)
Query: 1 MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNE 60
MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLK
Sbjct: 1 MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLK------------------------- 35
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS 120
TFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS
Sbjct: 36 -TFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS 94
Query: 121 YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES 180
YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES
Sbjct: 95 YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES 154
Query: 181 KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 240
KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD
Sbjct: 155 KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 214
Query: 241 GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV 300
GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV
Sbjct: 215 GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV 274
Query: 301 EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV 360
EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV
Sbjct: 275 EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV 334
Query: 361 TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY 420
TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY
Sbjct: 335 TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY 394
Query: 421 QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH 480
QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH
Sbjct: 395 QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH 454
Query: 481 NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA 540
NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA
Sbjct: 455 NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA 514
Query: 541 QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS 600
QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS
Sbjct: 515 QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS 574
Query: 601 PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS 660
PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS
Sbjct: 575 PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS 634
Query: 661 VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE 720
VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE
Sbjct: 635 VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE 694
Query: 721 GDLLVELE 728
GDLLVELE
Sbjct: 695 GDLLVELE 702
>gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
precursor [Homo sapiens]
Length = 725
Score = 469 bits (1206), Expect = e-132
Identities = 276/687 (40%), Positives = 403/687 (58%), Gaps = 37/687 (5%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS 120
+ K+L+ANRGEIACRV+RT KK+G++TVA++S+ D +S+HV MADEA +GPAP+ +S
Sbjct: 47 RNITKVLIANRGEIACRVMRTAKKLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQS 106
Query: 121 YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES 180
YL+M+ I++ K + AQA+HPG GFLSEN EFA E ++FIGP AI+ MG K S
Sbjct: 107 YLSMEKIIQVAKTSAAQAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTS 166
Query: 181 KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 240
K + A V + G+ G + + AR IGYPVMIKA GGGGKGMRI ++E ++
Sbjct: 167 KSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQE 226
Query: 241 GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV 300
+ +EA SF DD +LIEKF+D PRH+E+QV GD HGNA++L ER+CS+QRR+QK++
Sbjct: 227 QLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII 286
Query: 301 EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV 360
EEAP+ + +E R+ +GE AV A+AV Y AGTVEF++DSK NF F+EMNTRLQVEHPV
Sbjct: 287 EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPV 346
Query: 361 TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY 420
TE ITG DLV+ +R+A G + Q +I + G A E R+YAEDP +F +P G L
Sbjct: 347 TEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNF-MPVAGPLVHL 405
Query: 421 QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH 480
P P R+++G++ G ++S++YDPMI+KL+ + +DR AL ++ +L Y I G+
Sbjct: 406 STPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHT 465
Query: 481 NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTK--SEKNQLLAIASSLFV---- 534
NI L + + F G++ T F+ P K +L++ + K L A L +
Sbjct: 466 NIDFLLNLSGHPEFEAGNVHTDFI----PQHHKQLLLSRKAAAKESLCQAALGLILKEKA 521
Query: 535 ---AFQLRA-QHFQENSRMPVIKPDIANWELSVKLHD---KVHTVVASNNGSVFSVEVDG 587
F L+A F S + +I ++ ++ L D V V N+ +S++++
Sbjct: 522 MTDTFTLQAHDQFSPFSSSSGRRLNI-SYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIED 580
Query: 588 SKLNVTSTWNLAS----PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 643
V NL S L SV+G + + E T+Y + +
Sbjct: 581 KTFQVLG--NLYSEGDCTYLKCSVNGVASKAKLIILE----------NTIYLFSKEGSIE 628
Query: 644 AEL--NKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTA 701
++ K++ +++T +PM G + V VK GD V G + V+ AMKM++++ +
Sbjct: 629 IDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKS 688
Query: 702 GKTGTVKSVHCQAGDTVGEGDLLVELE 728
K GTVK V + G LVE E
Sbjct: 689 PKDGTVKKVFYREGAQANRHTPLVEFE 715
>gi|106049528 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (969), Expect = e-104
Identities = 202/452 (44%), Positives = 291/452 (64%), Gaps = 9/452 (1%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGP--APTS 118
K K++VANRGEIA RV R C ++GI+TVAI+S+ D +H + ADEA +G AP
Sbjct: 35 KPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPV- 93
Query: 119 KSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKI 178
++YL++ I++ K+ AVHPGYGFLSE +FA+ V FIGP ++ MGDK+
Sbjct: 94 QAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKV 153
Query: 179 ESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEET 238
E++ +A A V +PG D + EA + G+P++ KA+ GGGG+GMR+ EE
Sbjct: 154 EARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEEL 213
Query: 239 RDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQK 298
+ + + EA ++FG+ L +EKFI+ PRHIE+Q+LGD++GN L L ER+CSIQRR+QK
Sbjct: 214 EENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQK 273
Query: 299 VVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEH 358
VVE AP+ LD + R + +V LA+ V Y +AGTVEFLVD YF+E+N+RLQVEH
Sbjct: 274 VVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEH 333
Query: 359 PVTECITGLDLVQEMIRVAKGYPLRH---KQADIRINGWAVECRVYAEDPYKSFGLPSIG 415
VTE IT +DLV I VA+G L +Q +IRING A++CRV EDP +SF P G
Sbjct: 334 TVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSF-QPDTG 392
Query: 416 RLSQYQEPLHLPGVRVDSGIQ-PGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYV 474
R+ ++ + G+R+D+ G+ IS +YD ++ K+I +G D A +M+ AL +
Sbjct: 393 RIEVFRSGEGM-GIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFR 451
Query: 475 IRGVTHNIALLREVIINSRFVKGDISTKFLSD 506
+RGV NIA L+ V+ N +F+ G + T+F+ +
Sbjct: 452 VRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDE 483
Score = 62.8 bits (151), Expect = 1e-09
Identities = 30/76 (39%), Positives = 46/76 (60%)
Query: 653 KVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHC 712
K +D + +PMPG V+ + V G VA+GQ +CV+ AMKM+ +T+ GTV+ VH
Sbjct: 1103 KALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHV 1162
Query: 713 QAGDTVGEGDLLVELE 728
T+ DL++E+E
Sbjct: 1163 TKDMTLEGDDLILEIE 1178
>gi|106049295 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (969), Expect = e-104
Identities = 202/452 (44%), Positives = 291/452 (64%), Gaps = 9/452 (1%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGP--APTS 118
K K++VANRGEIA RV R C ++GI+TVAI+S+ D +H + ADEA +G AP
Sbjct: 35 KPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPV- 93
Query: 119 KSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKI 178
++YL++ I++ K+ AVHPGYGFLSE +FA+ V FIGP ++ MGDK+
Sbjct: 94 QAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKV 153
Query: 179 ESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEET 238
E++ +A A V +PG D + EA + G+P++ KA+ GGGG+GMR+ EE
Sbjct: 154 EARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEEL 213
Query: 239 RDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQK 298
+ + + EA ++FG+ L +EKFI+ PRHIE+Q+LGD++GN L L ER+CSIQRR+QK
Sbjct: 214 EENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQK 273
Query: 299 VVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEH 358
VVE AP+ LD + R + +V LA+ V Y +AGTVEFLVD YF+E+N+RLQVEH
Sbjct: 274 VVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEH 333
Query: 359 PVTECITGLDLVQEMIRVAKGYPLRH---KQADIRINGWAVECRVYAEDPYKSFGLPSIG 415
VTE IT +DLV I VA+G L +Q +IRING A++CRV EDP +SF P G
Sbjct: 334 TVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSF-QPDTG 392
Query: 416 RLSQYQEPLHLPGVRVDSGIQ-PGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYV 474
R+ ++ + G+R+D+ G+ IS +YD ++ K+I +G D A +M+ AL +
Sbjct: 393 RIEVFRSGEGM-GIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFR 451
Query: 475 IRGVTHNIALLREVIINSRFVKGDISTKFLSD 506
+RGV NIA L+ V+ N +F+ G + T+F+ +
Sbjct: 452 VRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDE 483
Score = 62.8 bits (151), Expect = 1e-09
Identities = 30/76 (39%), Positives = 46/76 (60%)
Query: 653 KVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHC 712
K +D + +PMPG V+ + V G VA+GQ +CV+ AMKM+ +T+ GTV+ VH
Sbjct: 1103 KALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHV 1162
Query: 713 QAGDTVGEGDLLVELE 728
T+ DL++E+E
Sbjct: 1163 TKDMTLEGDDLILEIE 1178
>gi|106049292 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (969), Expect = e-104
Identities = 202/452 (44%), Positives = 291/452 (64%), Gaps = 9/452 (1%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGP--APTS 118
K K++VANRGEIA RV R C ++GI+TVAI+S+ D +H + ADEA +G AP
Sbjct: 35 KPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPV- 93
Query: 119 KSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKI 178
++YL++ I++ K+ AVHPGYGFLSE +FA+ V FIGP ++ MGDK+
Sbjct: 94 QAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKV 153
Query: 179 ESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEET 238
E++ +A A V +PG D + EA + G+P++ KA+ GGGG+GMR+ EE
Sbjct: 154 EARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEEL 213
Query: 239 RDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQK 298
+ + + EA ++FG+ L +EKFI+ PRHIE+Q+LGD++GN L L ER+CSIQRR+QK
Sbjct: 214 EENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQK 273
Query: 299 VVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEH 358
VVE AP+ LD + R + +V LA+ V Y +AGTVEFLVD YF+E+N+RLQVEH
Sbjct: 274 VVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEH 333
Query: 359 PVTECITGLDLVQEMIRVAKGYPLRH---KQADIRINGWAVECRVYAEDPYKSFGLPSIG 415
VTE IT +DLV I VA+G L +Q +IRING A++CRV EDP +SF P G
Sbjct: 334 TVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSF-QPDTG 392
Query: 416 RLSQYQEPLHLPGVRVDSGIQ-PGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYV 474
R+ ++ + G+R+D+ G+ IS +YD ++ K+I +G D A +M+ AL +
Sbjct: 393 RIEVFRSGEGM-GIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFR 451
Query: 475 IRGVTHNIALLREVIINSRFVKGDISTKFLSD 506
+RGV NIA L+ V+ N +F+ G + T+F+ +
Sbjct: 452 VRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDE 483
Score = 62.8 bits (151), Expect = 1e-09
Identities = 30/76 (39%), Positives = 46/76 (60%)
Query: 653 KVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHC 712
K +D + +PMPG V+ + V G VA+GQ +CV+ AMKM+ +T+ GTV+ VH
Sbjct: 1103 KALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHV 1162
Query: 713 QAGDTVGEGDLLVELE 728
T+ DL++E+E
Sbjct: 1163 TKDMTLEGDDLILEIE 1178
>gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
sapiens]
Length = 2346
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 109
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 116 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 175
Query: 110 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 169
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 176 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 235
Query: 170 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 203
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 236 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 295
Query: 204 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 263
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 296 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 351
Query: 264 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 323
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 352 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 411
Query: 324 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 383
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 412 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 470
Query: 384 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 419
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 471 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 529
Query: 420 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 477
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 530 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 586
Query: 478 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 523
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 587 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 646
Query: 524 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 583
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 647 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 704
Query: 584 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 643
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 705 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 743
Query: 644 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 703
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 744 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 795
Query: 704 TGTVKSVHCQAGDTVGEGDLLVELE 728
+G + V + G + G +L +++
Sbjct: 796 SGCIHYVK-RPGAALDPGCVLAKMQ 819
>gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo
sapiens]
Length = 2268
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 109
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 38 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 97
Query: 110 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 169
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 98 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 157
Query: 170 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 203
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 158 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 217
Query: 204 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 263
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 218 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 273
Query: 264 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 323
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 274 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 333
Query: 324 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 383
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 334 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 392
Query: 384 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 419
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 393 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 451
Query: 420 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 477
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 452 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 508
Query: 478 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 523
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 509 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 568
Query: 524 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 583
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 569 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 626
Query: 584 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 643
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 627 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 665
Query: 644 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 703
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 666 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 717
Query: 704 TGTVKSVHCQAGDTVGEGDLLVELE 728
+G + V + G + G +L +++
Sbjct: 718 SGCIHYVK-RPGAALDPGCVLAKMQ 741
>gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo
sapiens]
Length = 2288
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 109
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 58 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 117
Query: 110 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 169
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 118 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 177
Query: 170 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 203
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 178 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 237
Query: 204 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 263
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 238 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 293
Query: 264 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 323
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 294 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 353
Query: 324 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 383
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 354 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 412
Query: 384 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 419
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 413 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 471
Query: 420 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 477
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 472 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 528
Query: 478 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 523
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 529 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 588
Query: 524 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 583
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 589 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 646
Query: 584 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 643
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 647 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 685
Query: 644 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 703
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 686 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 737
Query: 704 TGTVKSVHCQAGDTVGEGDLLVELE 728
+G + V + G + G +L +++
Sbjct: 738 SGCIHYVK-RPGAALDPGCVLAKMQ 761
>gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
sapiens]
Length = 2346
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 109
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 116 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 175
Query: 110 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 169
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 176 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 235
Query: 170 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 203
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 236 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 295
Query: 204 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 263
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 296 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 351
Query: 264 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 323
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 352 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 411
Query: 324 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 383
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 412 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 470
Query: 384 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 419
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 471 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 529
Query: 420 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 477
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 530 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 586
Query: 478 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 523
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 587 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 646
Query: 524 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 583
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 647 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 704
Query: 584 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 643
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 705 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 743
Query: 644 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 703
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 744 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 795
Query: 704 TGTVKSVHCQAGDTVGEGDLLVELE 728
+G + V + G + G +L +++
Sbjct: 796 SGCIHYVK-RPGAALDPGCVLAKMQ 819
>gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo
sapiens]
Length = 2383
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 61 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 109
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 153 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 212
Query: 110 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 169
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 213 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 272
Query: 170 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 203
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 273 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 332
Query: 204 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 263
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 333 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 388
Query: 264 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 323
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 389 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 448
Query: 324 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 383
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 449 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 507
Query: 384 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 419
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 508 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 566
Query: 420 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 477
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 567 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 623
Query: 478 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 523
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 624 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 683
Query: 524 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 583
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 684 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 741
Query: 584 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 643
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 742 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 780
Query: 644 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 703
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 781 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 832
Query: 704 TGTVKSVHCQAGDTVGEGDLLVELE 728
+G + V + G + G +L +++
Sbjct: 833 SGCIHYVK-RPGAALDPGCVLAKMQ 856
>gi|134142062 acetyl-Coenzyme A carboxylase beta [Homo sapiens]
Length = 2458
Score = 246 bits (627), Expect = 7e-65
Identities = 207/744 (27%), Positives = 342/744 (45%), Gaps = 113/744 (15%)
Query: 60 EKTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADE 108
++ +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 257 DRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADH 316
Query: 109 AVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDT 168
V V P + +Y N++ I++ K+ QAV G+G SEN + L V F+GP +
Sbjct: 317 YVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPS 376
Query: 169 HAIQAMGDKIESKLLAKKAEVNTIPG--------------------------FD-GVVKD 201
A+ A+GDKI S ++A+ +V T+P +D G VKD
Sbjct: 377 EAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKD 436
Query: 202 AEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 261
+E + A IG+P+MIKAS GGGGKG+R A E+ + F + ++ S + +
Sbjct: 437 VDEGLEAAERIGFPLMIKASEGGGGKGIRKA----ESAEDFPILFRQVQSEIPGSPIFLM 492
Query: 262 KFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAV 321
K + RH+E+Q+L D++GNA+ L R+CSIQRR+QK+VEEAP+ M + A+
Sbjct: 493 KLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAI 552
Query: 322 ALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYP 381
LA+ V Y SAGTVE+L +F+FLE+N RLQVEHP TE I ++L +++A G P
Sbjct: 553 RLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVP 612
Query: 382 LRHKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLS 418
L H+ DIR+ G + R+ +E+P + F PS G +
Sbjct: 613 L-HRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGF-KPSSGTVQ 670
Query: 419 Q--YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIR 476
+ ++ ++ G + + + D ++G +R EA+ M AL IR
Sbjct: 671 ELNFRSSKNVWGY---FSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIR 727
Query: 477 G-VTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQL--------LA 527
G + L ++ F DI T +L + + ++EK + L
Sbjct: 728 GDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAE------KVQAEKPDIMLGVVCGALN 781
Query: 528 IASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKL---HDKVHTVVASNNGSVFSVE 584
+A ++F H E R V+ D + V+L K VA + ++F +
Sbjct: 782 VADAMFRTCMTDFLHSLE--RGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLI 839
Query: 585 VDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAA 644
++G + + L L +S +G T + E Y++ I +
Sbjct: 840 MNGCHIEI-DAHRLNDGGLLLSYNGNSYTTY-MKEEVDS----------YRITIGNKTC- 886
Query: 645 ELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKT 704
+ EK E+ +VLRSP G + +V+ G V G +E MKM ++ +
Sbjct: 887 -----VFEK--ENDPTVLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQER 939
Query: 705 GTVKSVHCQAGDTVGEGDLLVELE 728
G VK + + G + G ++ LE
Sbjct: 940 GRVKYIK-RPGAVLEAGCVVARLE 962
>gi|18105007 carbamoylphosphate synthetase 2/aspartate
transcarbamylase/dihydroorotase [Homo sapiens]
Length = 2225
Score = 62.8 bits (151), Expect = 1e-09
Identities = 71/316 (22%), Positives = 133/316 (42%), Gaps = 28/316 (8%)
Query: 77 RVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRA 136
+ I+ K+ I+T+ I+ ++ +AD+ + P + Y + + I+ R
Sbjct: 418 QAIKALKEENIQTLLINPNIATVQTSQGLADKVYFL---PITPHY-----VTQVIRNERP 469
Query: 137 QAVHPGYG---FLSENKEFARC--LAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNT 191
V +G L+ E + LA V +G I+ D+ A+ AE+
Sbjct: 470 DGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDR--RAFAARMAEIGE 527
Query: 192 IPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAAS 251
E+A A +GYPV+++A+ GG G A + EE LS+ A +
Sbjct: 528 HVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREE------LSALVAPA 581
Query: 252 SFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERE----CSIQRRNQKVVEEAPSIF 307
++L++K + + IE +V+ D +GN + + E I VV APS
Sbjct: 582 FAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVV--APSQT 639
Query: 308 LDAETRRAMGEQAVALARAVKYSSAGTVEFLVD-SKKNFYFLEMNTRLQVEHPVTECITG 366
L+ + + + A+ + + + V++ ++ + +Y +E+N RL + TG
Sbjct: 640 LNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATG 699
Query: 367 LDLVQEMIRVAKGYPL 382
L ++A G PL
Sbjct: 700 YPLAYVAAKLALGIPL 715
Score = 46.6 bits (109), Expect = 8e-05
Identities = 65/305 (21%), Positives = 117/305 (38%), Gaps = 23/305 (7%)
Query: 79 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 138
I+ +KMG KT+ ++ + + S M D ++ + +M+ + +
Sbjct: 959 IQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYF--------DEISFEVVMDIYELENPEG 1010
Query: 139 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 198
V G N A L + +G AI + ++ + L ++ +
Sbjct: 1011 VILSMGGQLPN-NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRE-- 1067
Query: 199 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 258
+ D E A + + +GYP +++ S G M +A+ D + R S AA S + +
Sbjct: 1068 LSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLE---RFLSSAAAVS-KEHPV 1123
Query: 259 LIEKFIDNPRHIEIQ-VLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMG 317
+I KFI + I++ V D A+ ++E + + P + A+T
Sbjct: 1124 VISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTL---- 1179
Query: 318 EQAVALARAVKYSSAGTVEF---LVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMI 374
E+ A+ AV T F L+ +E N R+ P G+DLV
Sbjct: 1180 ERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALAT 1239
Query: 375 RVAKG 379
RV G
Sbjct: 1240 RVIMG 1244
>gi|169790915 carbamoyl-phosphate synthetase 1 isoform a precursor
[Homo sapiens]
Length = 1506
Score = 56.2 bits (134), Expect = 1e-07
Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 33/320 (10%)
Query: 77 RVIRTCKKMGIKTVAIH---SDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKK 133
+ ++ K+ +KTV ++ + V + V +K AD + P + E IK
Sbjct: 453 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITP--------QFVTEVIKA 504
Query: 134 TRAQAVHPGYG---FLSENKE-FARCLAAE-DVVFIGPDTHAIQAMGDKIESKLLAKKA- 187
+ + G G L+ E F R + E V +G +I A D+ +L + K
Sbjct: 505 EQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDR---QLFSDKLN 561
Query: 188 EVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQ 247
E+N V+ E+A++ A IGYPVMI+++ GG G I + E D LS++
Sbjct: 562 EINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMD---LSTK 618
Query: 248 EAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWL----NERECSIQRRNQKVVEEA 303
A + +++L+EK + + IE +V+ D N + + N + + VV A
Sbjct: 619 AFAMT---NQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--A 673
Query: 304 PSIFLDAETRRAMGEQAVALARAVKYSSAGTVEF-LVDSKKNFYFLEMNTRLQVEHPVTE 362
P+ L + + ++ + R + ++F L + + +E+N RL +
Sbjct: 674 PAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALAS 733
Query: 363 CITGLDLVQEMIRVAKGYPL 382
TG L ++A G PL
Sbjct: 734 KATGYPLAFIAAKIALGIPL 753
Score = 43.9 bits (102), Expect = 5e-04
Identities = 60/311 (19%), Positives = 117/311 (37%), Gaps = 35/311 (11%)
Query: 79 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 138
IRT +++G KTV ++ + + S D+ L+++ I++ +
Sbjct: 1006 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 1057
Query: 139 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 198
G N A L V +G I D+ + + +V P
Sbjct: 1058 CIISVGGQIPNN-LAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPW--KA 1114
Query: 199 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 258
V EA+ A+ + YP +++ S G M + + ++E + +EA + +
Sbjct: 1115 VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFL----EEATRVSQEHPV 1170
Query: 259 LIEKFIDNPRHIEIQVLG----------DKHGNALWLNERECSIQRRNQKVVEEAPSIFL 308
++ KF++ R +E+ +G +H ++ + ++ Q + + A
Sbjct: 1171 VLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVK 1230
Query: 309 DAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD 368
DA TR+ +A+A S V+FLV + +E N R P G+D
Sbjct: 1231 DA-TRK--------IAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVD 1280
Query: 369 LVQEMIRVAKG 379
+ +V G
Sbjct: 1281 FIDVATKVMIG 1291
>gi|21361331 carbamoyl-phosphate synthetase 1 isoform b precursor
[Homo sapiens]
Length = 1500
Score = 56.2 bits (134), Expect = 1e-07
Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 33/320 (10%)
Query: 77 RVIRTCKKMGIKTVAIH---SDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKK 133
+ ++ K+ +KTV ++ + V + V +K AD + P + E IK
Sbjct: 447 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITP--------QFVTEVIKA 498
Query: 134 TRAQAVHPGYG---FLSENKE-FARCLAAE-DVVFIGPDTHAIQAMGDKIESKLLAKKA- 187
+ + G G L+ E F R + E V +G +I A D+ +L + K
Sbjct: 499 EQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDR---QLFSDKLN 555
Query: 188 EVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQ 247
E+N V+ E+A++ A IGYPVMI+++ GG G I + E D LS++
Sbjct: 556 EINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMD---LSTK 612
Query: 248 EAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWL----NERECSIQRRNQKVVEEA 303
A + +++L+EK + + IE +V+ D N + + N + + VV A
Sbjct: 613 AFAMT---NQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--A 667
Query: 304 PSIFLDAETRRAMGEQAVALARAVKYSSAGTVEF-LVDSKKNFYFLEMNTRLQVEHPVTE 362
P+ L + + ++ + R + ++F L + + +E+N RL +
Sbjct: 668 PAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALAS 727
Query: 363 CITGLDLVQEMIRVAKGYPL 382
TG L ++A G PL
Sbjct: 728 KATGYPLAFIAAKIALGIPL 747
Score = 43.9 bits (102), Expect = 5e-04
Identities = 60/311 (19%), Positives = 117/311 (37%), Gaps = 35/311 (11%)
Query: 79 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 138
IRT +++G KTV ++ + + S D+ L+++ I++ +
Sbjct: 1000 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 1051
Query: 139 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 198
G N A L V +G I D+ + + +V P
Sbjct: 1052 CIISVGGQIPNN-LAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPW--KA 1108
Query: 199 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 258
V EA+ A+ + YP +++ S G M + + ++E + +EA + +
Sbjct: 1109 VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFL----EEATRVSQEHPV 1164
Query: 259 LIEKFIDNPRHIEIQVLG----------DKHGNALWLNERECSIQRRNQKVVEEAPSIFL 308
++ KF++ R +E+ +G +H ++ + ++ Q + + A
Sbjct: 1165 VLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVK 1224
Query: 309 DAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD 368
DA TR+ +A+A S V+FLV + +E N R P G+D
Sbjct: 1225 DA-TRK--------IAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVD 1274
Query: 369 LVQEMIRVAKG 379
+ +V G
Sbjct: 1275 FIDVATKVMIG 1285
>gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo
sapiens]
Length = 1049
Score = 54.3 bits (129), Expect = 4e-07
Identities = 77/314 (24%), Positives = 135/314 (42%), Gaps = 33/314 (10%)
Query: 83 KKMGIKTVAIH---SDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAV 139
K+ +KTV ++ + V + V +K AD + P + E IK + +
Sbjct: 2 KEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITP--------QFVTEVIKAEQPDGL 53
Query: 140 HPGYG---FLSENKE-FARCLAAE-DVVFIGPDTHAIQAMGDKIESKLLAKKA-EVNTIP 193
G G L+ E F R + E V +G +I A D+ +L + K E+N
Sbjct: 54 ILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDR---QLFSDKLNEINEKI 110
Query: 194 GFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSF 253
V+ E+A++ A IGYPVMI+++ GG G I + E D LS++ A +
Sbjct: 111 APSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMD---LSTKAFAMT- 166
Query: 254 GDDRLLIEKFIDNPRHIEIQVLGDKHGNALWL----NERECSIQRRNQKVVEEAPSIFLD 309
+++L+EK + + IE +V+ D N + + N + + VV AP+ L
Sbjct: 167 --NQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLS 222
Query: 310 AETRRAMGEQAVALARAVKYSSAGTVEF-LVDSKKNFYFLEMNTRLQVEHPVTECITGLD 368
+ + ++ + R + ++F L + + +E+N RL + TG
Sbjct: 223 NAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYP 282
Query: 369 LVQEMIRVAKGYPL 382
L ++A G PL
Sbjct: 283 LAFIAAKIALGIPL 296
Score = 43.9 bits (102), Expect = 5e-04
Identities = 60/311 (19%), Positives = 117/311 (37%), Gaps = 35/311 (11%)
Query: 79 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 138
IRT +++G KTV ++ + + S D+ L+++ I++ +
Sbjct: 549 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 600
Query: 139 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 198
G N A L V +G I D+ + + +V P
Sbjct: 601 CIISVGGQIPNN-LAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPW--KA 657
Query: 199 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 258
V EA+ A+ + YP +++ S G M + + ++E + +EA + +
Sbjct: 658 VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFL----EEATRVSQEHPV 713
Query: 259 LIEKFIDNPRHIEIQVLG----------DKHGNALWLNERECSIQRRNQKVVEEAPSIFL 308
++ KF++ R +E+ +G +H ++ + ++ Q + + A
Sbjct: 714 VLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVK 773
Query: 309 DAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD 368
DA TR+ +A+A S V+FLV + +E N R P G+D
Sbjct: 774 DA-TRK--------IAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVD 823
Query: 369 LVQEMIRVAKG 379
+ +V G
Sbjct: 824 FIDVATKVMIG 834
>gi|110671329 dihydrolipoamide branched chain transacylase precursor
[Homo sapiens]
Length = 482
Score = 33.1 bits (74), Expect = 0.94
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 675 VKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLVELE 728
VK GD V++ IC +++ K ++T+ G +K ++ D G LV++E
Sbjct: 86 VKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAYVGKPLVDIE 139
>gi|212549738 anaphase-promoting complex subunit 7 isoform b [Homo
sapiens]
Length = 537
Score = 32.3 bits (72), Expect = 1.6
Identities = 23/99 (23%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 294 RRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLE-MNT 352
++ Q +V A S+F D E R A+ + +AL + S V + + + + +
Sbjct: 75 QKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPS 134
Query: 353 RLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIRI 391
++V++ + EC T L ++ I + G P R + I +
Sbjct: 135 EIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINM 173
>gi|212549736 anaphase-promoting complex subunit 7 isoform a [Homo
sapiens]
Length = 599
Score = 32.3 bits (72), Expect = 1.6
Identities = 23/99 (23%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 294 RRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLE-MNT 352
++ Q +V A S+F D E R A+ + +AL + S V + + + + +
Sbjct: 75 QKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPS 134
Query: 353 RLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIRI 391
++V++ + EC T L ++ I + G P R + I +
Sbjct: 135 EIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINM 173
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 30.4 bits (67), Expect = 6.1
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 13/61 (21%)
Query: 60 EKTFDKILVANR-------GEIACRVIRTCKKMGIKTVAIHSDVDASSV------HVKMA 106
+K + K+L N GEIA ++R + + K IH DV S+V HVKM
Sbjct: 153 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 212
Query: 107 D 107
D
Sbjct: 213 D 213
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 30.4 bits (67), Expect = 6.1
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 13/61 (21%)
Query: 60 EKTFDKILVANR-------GEIACRVIRTCKKMGIKTVAIHSDVDASSV------HVKMA 106
+K + K+L N GEIA ++R + + K IH DV S+V HVKM
Sbjct: 40 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 99
Query: 107 D 107
D
Sbjct: 100 D 100
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 30.4 bits (67), Expect = 6.1
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 13/61 (21%)
Query: 60 EKTFDKILVANR-------GEIACRVIRTCKKMGIKTVAIHSDVDASSV------HVKMA 106
+K + K+L N GEIA ++R + + K IH DV S+V HVKM
Sbjct: 119 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 178
Query: 107 D 107
D
Sbjct: 179 D 179
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 30.4 bits (67), Expect = 6.1
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 13/61 (21%)
Query: 60 EKTFDKILVANR-------GEIACRVIRTCKKMGIKTVAIHSDVDASSV------HVKMA 106
+K + K+L N GEIA ++R + + K IH DV S+V HVKM
Sbjct: 148 DKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMC 207
Query: 107 D 107
D
Sbjct: 208 D 208
>gi|28416899 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 2 [Homo
sapiens]
Length = 433
Score = 30.4 bits (67), Expect = 6.1
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 203 EEAVRIAREIGYPVMI-KASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 261
EEA +P ++ KAS GKG+ +A EE + QE A + ++IE
Sbjct: 131 EEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIE 190
Query: 262 KFID 265
+ +D
Sbjct: 191 ELLD 194
>gi|4503915 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 30.4 bits (67), Expect = 6.1
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 203 EEAVRIAREIGYPVMI-KASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 261
EEA +P ++ KAS GKG+ +A EE + QE A + ++IE
Sbjct: 131 EEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIE 190
Query: 262 KFID 265
+ +D
Sbjct: 191 ELLD 194
>gi|209869995 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 30.4 bits (67), Expect = 6.1
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 203 EEAVRIAREIGYPVMI-KASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 261
EEA +P ++ KAS GKG+ +A EE + QE A + ++IE
Sbjct: 131 EEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIE 190
Query: 262 KFID 265
+ +D
Sbjct: 191 ELLD 194
>gi|209869993 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 30.4 bits (67), Expect = 6.1
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 203 EEAVRIAREIGYPVMI-KASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 261
EEA +P ++ KAS GKG+ +A EE + QE A + ++IE
Sbjct: 131 EEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIE 190
Query: 262 KFID 265
+ +D
Sbjct: 191 ELLD 194
>gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]
Length = 3996
Score = 30.4 bits (67), Expect = 6.1
Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 6/69 (8%)
Query: 607 VDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSSVLRSPM 666
VD ++TV+ L E GG +L T+ + E NKF ++KV + + V RSP
Sbjct: 2291 VDIARQTVEFLYEENGGIPRDLYLPTIEDIK------DEANKFTIDKVRKGLTVVTRSPD 2344
Query: 667 PGVVVAVSV 675
V + +V
Sbjct: 2345 SNNVASSAV 2353
>gi|4505941 DNA directed RNA polymerase II polypeptide B [Homo
sapiens]
Length = 1174
Score = 30.0 bits (66), Expect = 7.9
Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 21/85 (24%)
Query: 234 DDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQ 293
DDE T D ++ + SS+ D++ L+ + +D+ IQ
Sbjct: 14 DDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEF---------------------IQ 52
Query: 294 RRNQKVVEEAPSIFLDAETRRAMGE 318
Q++VE+AP I L AE + A GE
Sbjct: 53 MSVQRIVEDAPPIDLQAEAQHASGE 77
>gi|134133279 SP140 nuclear body protein-like [Homo sapiens]
Length = 580
Score = 30.0 bits (66), Expect = 7.9
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 16 RRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVA-NRGEI 74
R G WP ++LM +L + Y +++ ++ S+N SV DP + D+ V + GE+
Sbjct: 358 RCGGWPLRRLMEEGSLPNPPRIYYRNKKRILKSQNNSSV--DPCMRNLDECEVCRDGGEL 415
Query: 75 ACRVIRTCKKM 85
C TC ++
Sbjct: 416 FC--CDTCSRV 424
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,297,301
Number of Sequences: 37866
Number of extensions: 1023222
Number of successful extensions: 2595
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2507
Number of HSP's gapped (non-prelim): 59
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.