Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 64276808
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|64276808 ADAM metallopeptidase with thrombospondin type 1
motif, 6 preproprotein [Homo sapiens]
(1117 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 2405 0.0
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 1447 0.0
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 801 0.0
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 748 0.0
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 745 0.0
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 720 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 650 0.0
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 618 e-176
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 590 e-168
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 573 e-163
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 550 e-156
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 541 e-153
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 517 e-146
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 514 e-145
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 486 e-137
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 481 e-135
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 452 e-126
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 426 e-119
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 412 e-115
gi|145309328 papilin [Homo sapiens] 363 e-100
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 345 1e-94
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 345 1e-94
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 321 2e-87
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 302 1e-81
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 286 6e-77
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 285 1e-76
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 275 1e-73
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 270 6e-72
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 270 6e-72
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 249 8e-66
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 2405 bits (6232), Expect = 0.0
Identities = 1117/1117 (100%), Positives = 1117/1117 (100%)
Query: 1 MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT 60
MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT
Sbjct: 1 MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT 60
Query: 61 VKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDG 120
VKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDG
Sbjct: 61 VKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDG 120
Query: 121 PQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHF 180
PQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHF
Sbjct: 121 PQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHF 180
Query: 181 SYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHH 240
SYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHH
Sbjct: 181 SYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHH 240
Query: 241 RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA 300
RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA
Sbjct: 241 RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA 300
Query: 301 RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD 360
RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD
Sbjct: 301 RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD 360
Query: 361 ICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC 420
ICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC
Sbjct: 361 ICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC 420
Query: 421 GTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAP 480
GTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAP
Sbjct: 421 GTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAP 480
Query: 481 GQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKG 540
GQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKG
Sbjct: 481 GQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKG 540
Query: 541 WCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGE 600
WCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGE
Sbjct: 541 WCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGE 600
Query: 601 RKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYN 660
RKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYN
Sbjct: 601 RKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYN 660
Query: 661 FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE 720
FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE
Sbjct: 661 FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE 720
Query: 721 GFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKF 780
GFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKF
Sbjct: 721 GFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKF 780
Query: 781 DVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEV 840
DVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEV
Sbjct: 781 DVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEV 840
Query: 841 GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP
Sbjct: 841 GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
Query: 901 PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP 960
PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP
Sbjct: 901 PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP 960
Query: 961 PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP 1020
PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP
Sbjct: 961 PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP 1020
Query: 1021 RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNT 1080
RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNT
Sbjct: 1021 RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNT 1080
Query: 1081 EECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH 1117
EECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH
Sbjct: 1081 EECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH 1117
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 1447 bits (3745), Expect = 0.0
Identities = 671/1114 (60%), Positives = 838/1114 (75%), Gaps = 22/1114 (1%)
Query: 8 LTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHS 67
L W L+L + F H ++ SQ+EFL+ LE Y++ P RVD NGA L+F+ +
Sbjct: 8 LRWALALGLGLM-FEVTH--AFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQ 64
Query: 68 RRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDF 127
RR A S+LF+K+++ HF LNLT ++ ++ H +VEYW ++G W+
Sbjct: 65 RRGTGAT------AESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAA 118
Query: 128 LDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHP 187
+C Y G+LQ Q ST+ VA+S C GLHG+I ++EEY IEPL + S+ S E P
Sbjct: 119 RPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSR--SPEESGP 176
Query: 188 HVIYKKSALQQRHLYDHSHCGVSDFTR-SGKPWWLNDTSTVSYSLPINNTHIHHRQ--KR 244
HV+YK+S+L+ HL + CGV D G+PWWL T + P+ N + KR
Sbjct: 177 HVVYKRSSLRHPHL--DTACGVRDEKPWKGRPWWLR-TLKPPPARPLGNETERGQPGLKR 233
Query: 245 SVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIV 304
SVS ER+VETLVVADKMMV YHGR+D+E Y+L++MNIVAKL++DSSLG+ VNI+V RLI+
Sbjct: 234 SVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLIL 293
Query: 305 LTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTY 364
LTEDQP LEI HHA KSLDSFCKWQKSI++H GN IPENG+A+HD AVLITRYDIC Y
Sbjct: 294 LTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIY 353
Query: 365 KNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKG 424
KNKPCGTLGLA V GMCE ERSCS+NEDIGL +AFTIAHEIGH FGMNHDG+GNSCG +G
Sbjct: 354 KNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARG 413
Query: 425 HEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVY 484
+ AKLMAAHIT TNPF WS+CSRDYITSFLDSG G CL+N PP++DF+YP VAPGQ Y
Sbjct: 414 QDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAY 473
Query: 485 DADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQ 544
DADEQCRFQ+G SRQCKYGEVC ELWCLSKSNRC+TNSIPAAEGTLCQT I+KGWCY+
Sbjct: 474 DADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYK 533
Query: 545 GDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRY 604
CVPFG+ P+ +DG WGPW+ WG+CSRTCGGGVSSS RHCDSP P+ GGKYCLGER+R+
Sbjct: 534 RVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRH 593
Query: 605 RSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTE 664
RSCNTD CP GS+DFRE QC++FD++PFRGK+Y WK Y GGGVK C+L CLAEG+NFYTE
Sbjct: 594 RSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTE 653
Query: 665 RAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFN 724
RA AV+DGT C D++DIC++GECKHVGCD +LGSD RED+CRVCGGDGS C+ IEG F+
Sbjct: 654 RAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFS 713
Query: 725 DSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAG 784
+ P GY +VV IP+GSVHI ++++ +S +++ALK + + + G P + +AG
Sbjct: 714 PASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAG 773
Query: 785 TAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTW 844
T F ++ D+ +SLEALGP + +LIVMVL + + +RY+FN PI R D+ ++W
Sbjct: 774 TTFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIAR----DSLPPYSW 829
Query: 845 NHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWF 904
++ PW++CSA CAGG Q Q V C+ D+S V +YC SK P+ QRACNTEPCPP+W
Sbjct: 830 HYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWV 889
Query: 905 IGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWV 964
+G+W CS++CD G+R+R+V+C R++ +EE+ LD S C RP E C+ +CPP+W
Sbjct: 890 VGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWA 949
Query: 965 ALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVT 1024
ALDWSECTP CGPG +HR+VLCKS+D T P A C +KPP +RC+L RCPP RWV
Sbjct: 950 ALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVA 1009
Query: 1025 GDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDS-TPISNTEEC 1083
G+WG+CSAQCG+GQ+ R+V+C S+TGQAS +C E +RPP+ QQCE+KCDS TP EEC
Sbjct: 1010 GEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEEC 1069
Query: 1084 KDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH 1117
KDVNKVAYCPLVLKF+FCSRAYFRQMCCKTCQGH
Sbjct: 1070 KDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQGH 1103
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 801 bits (2068), Expect = 0.0
Identities = 417/1050 (39%), Positives = 604/1050 (57%), Gaps = 73/1050 (6%)
Query: 40 EHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLN 99
+ Y P+ VD G+++S + ++ R++RS Q A S L ++ SA+G+ HL
Sbjct: 59 DDYVFVTPVEVDSAGSYISHDILHN--GRKKRSA-----QNARSSLHYRFSAFGQELHLE 111
Query: 100 LTLNTDFVSKHFTVEYWGKDGP-QWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVI 158
L + +S HF V+ GKDG + + + C Y G++++ S++ VA+S C GL G+I
Sbjct: 112 LKPSA-ILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRND-SSSSVAVSTCAGLSGLI 169
Query: 159 ATEDEEYFIEPLKNTTEDSKHFSYENGH-PHVIYKKSA---LQQRHLYDHSHCGVSDFTR 214
T E+ I PL ++S GH PHV+YK++A +Q+ Y S ++
Sbjct: 170 RTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSP 229
Query: 215 SGKPWWLNDTSTVSYSLPINNTHIHHRQKRSV-------SIERF---------------- 251
S P T + + H R+K+ + RF
Sbjct: 230 SHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKS 289
Query: 252 -----VETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLT 306
VETLVVADK MV HG+ ++ YIL+VMN+V+ L++D ++G+ +N++V LI+L
Sbjct: 290 QKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLE 349
Query: 307 EDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKN 366
++ L INHHAD+SL+SFC+WQ +++ +NG HD+A+L+T +DIC++KN
Sbjct: 350 QEPGGLLINHHADQSLNSFCQWQSALIG---------KNG-KRHDHAILLTGFDICSWKN 399
Query: 367 KPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHE 426
+PC TLG A ++GMC RSC+INED GLG AFTIAHE GHNFGM HDG GN C
Sbjct: 400 EPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKA--- 456
Query: 427 AAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKR-DFLYPAVAPGQVYD 485
+M+ +T N FSWS+CSR Y+ FL + + CL +EP + + YP PGQ+YD
Sbjct: 457 EGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYD 516
Query: 486 ADEQCRFQYGATSRQCKYG---EVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWC 542
AD QC++Q+GA ++ C G ++C+ LWC +RC T +PAAEGT+C WC
Sbjct: 517 ADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSM----WC 572
Query: 543 YQGDCVPFGTW-PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGER 601
QG CV FG P+ I G W WS W ECSRTCGGGV RHC++P P GG +C G
Sbjct: 573 RQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSS 632
Query: 602 KRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKP-CALNCLAEGYN 660
+ Y+ CN +PC S DFR +QCA++++ PFRG +Y WKPYT + C L C AE +
Sbjct: 633 RIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFE 692
Query: 661 FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE 720
F+ + V DGT C+ + D+CI+G C+ VGCD+ LGS A D C VC GD STC +
Sbjct: 693 FFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYK 752
Query: 721 GFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKF 780
G + + Y VV IP G+ IE++E+ +S +Y+A++S YY+ G W+IDWP +F
Sbjct: 753 GLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEF 812
Query: 781 DVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGS--GDN 838
AGT F Y+R + PE L A GPT+E L+ +L+Q +N GI +K+ +P G+
Sbjct: 813 PFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATK 872
Query: 839 EVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEP 898
+TW+ SECS +C GG + +C R D N+ V +++C +KP + CN
Sbjct: 873 RPAYTWSIVQ-SECSVSCGGGYINVKAICLR-DQNTQVNSSFCSAKTKPVTEPKICNAFS 930
Query: 899 CPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQS 958
CP W G+W CSK C GG ++R + C++K +EE + +S C P + + CN+ +
Sbjct: 931 CPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHA 990
Query: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
CPPQW WS+C+ CG G + R +LCK S ++T P +QC +P ++ C LGRCP
Sbjct: 991 CPPQWSLGPWSQCSKTCGRGVRKRELLCKGS-AAETLPESQCTSLPRPELQEGCVLGRCP 1049
Query: 1019 PP---RWVTGDWGQCSAQCGLGQQMRTVQC 1045
+WV W +CSA CGLG + R ++C
Sbjct: 1050 KNSRLQWVASSWSECSATCGLGVRKREMKC 1079
Score = 71.6 bits (174), Expect = 4e-12
Identities = 44/130 (33%), Positives = 60/130 (46%), Gaps = 20/130 (15%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVC--KRLDDNSIV-QNNYCDPDSKPP-ENQRACNTEPC 899
W WSECSATC GV+++E+ C K I C KP + + CN C
Sbjct: 1056 WVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRAC 1115
Query: 900 PPE--------WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTH-RPVE 950
P W+ W +C+ TC GG++TR+V C+++ PS S CL H +P
Sbjct: 1116 PAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPS-------SSCLLHQKPPV 1168
Query: 951 KEPCNNQSCP 960
CN CP
Sbjct: 1169 LRACNTNFCP 1178
Score = 52.4 bits (124), Expect = 2e-06
Identities = 31/110 (28%), Positives = 54/110 (49%), Gaps = 8/110 (7%)
Query: 969 SECTPKCGPGFKHRIVLC---KSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTG 1025
SEC+ CG G+ + +C +++ ++ +F +A+ ++P + C+ CP W+ G
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKI---CNAFSCPA-YWMPG 938
Query: 1026 DWGQCSAQCGLGQQMRTVQCLSYTG-QASSDCLETVRPPSMQQCESKCDS 1074
+W CS C GQQ R +QC+ Q L ++ P S C+S
Sbjct: 939 EWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNS 988
Score = 43.1 bits (100), Expect = 0.001
Identities = 40/137 (29%), Positives = 60/137 (43%), Gaps = 13/137 (9%)
Query: 498 SRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIE-KGWCYQGDCVPFGTWPQS 556
S C G RE+ C K + + P + N++ + C + C + +
Sbjct: 1065 SATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVY--N 1122
Query: 557 IDGGWGPWSL-WGECSRTCGGGVSSSLRHC-DSPAPSGGGKYCLGERKR--YRSCNTDPC 612
+ GW +SL W +C+ TCGGGV + HC PS CL +K R+CNT+ C
Sbjct: 1123 MVAGW--YSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSS---CLLHQKPPVLRACNTNFC 1177
Query: 613 PLGSRDFREKQCADFDN 629
P + + C DF N
Sbjct: 1178 PAPEKR-EDPSCVDFFN 1193
Score = 41.6 bits (96), Expect = 0.004
Identities = 59/243 (24%), Positives = 91/243 (37%), Gaps = 50/243 (20%)
Query: 441 PFSWSACSRDYITSFLDSGRGTCLDNEPPKRD-----FLYPAVAPGQVYDADEQ-CRFQY 494
P WS CS+ S + C+ +P +++ L P P QV + C Q+
Sbjct: 937 PGEWSTCSKA-CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQW 995
Query: 495 GA-----TSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVP 549
S+ C G REL C + ++P ++ T +++G C G C
Sbjct: 996 SLGPWSQCSKTCGRGVRKRELLCKGSA----AETLPESQCTSLPRPELQEG-CVLGRC-- 1048
Query: 550 FGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYR---- 605
P++ W S W ECS TCG GV C GK +R R
Sbjct: 1049 ----PKNSRLQWVA-SSWSECSATCGLGVRKREMKCSEKGFQ--GKLITFPERRCRNIKK 1101
Query: 606 -------SCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYT---GGGVKPCALNCL 655
+CN CP A + ++P W+ T GGGV+ +++C+
Sbjct: 1102 PNLDLEETCNRRACPAHP---VYNMVAGWYSLP-------WQQCTVTCGGGVQTRSVHCV 1151
Query: 656 AEG 658
+G
Sbjct: 1152 QQG 1154
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 748 bits (1930), Expect = 0.0
Identities = 413/1001 (41%), Positives = 555/1001 (55%), Gaps = 65/1001 (6%)
Query: 47 PIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDF 106
P+RVD G+FLS+ + R R D + A + F++L G+ NLT N
Sbjct: 48 PVRVDAGGSFLSYEL----WPRALRKRDVSVRRDAPA--FYELQYRGRELRFNLTANQHL 101
Query: 107 VSKHFTVEYWGKDGPQWKH--DFLDNCHYTGYLQD-QRSTTKVALSNCVGLHGVIATEDE 163
++ F E + G H CH G +QD + A+S C GL GV +E
Sbjct: 102 LAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNE 161
Query: 164 EYFIEPLKNTTEDSKHFSYENGHPHVIYKKSA----LQQRHLYDHSHCGVSDFTR--SGK 217
+YFIEPL + H PHV+YK+ A Q+ S CGV + S +
Sbjct: 162 DYFIEPLDSAPARPGH-----AQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRR 216
Query: 218 PWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILS 277
W + +RSVS E++VETLVVAD MV YHG+ +E Y+L+
Sbjct: 217 ERWEQRQQW-------RRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLT 269
Query: 278 VMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQS 337
+MN+VA L+ D S+GN ++I + RL++L +++ +L+I HHAD +L SFCKWQKSI
Sbjct: 270 IMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSI---NM 326
Query: 338 DGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGS 397
G+ P HHD A+L+TR D+C N+PC TLGL+ VAGMC+P RSCSINED GL
Sbjct: 327 KGDAHP----LHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPL 382
Query: 398 AFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLD 457
AFT+AHE+GH+FG+ HDG GN C G +M+ + + P +WS CSR YIT FLD
Sbjct: 383 AFTVAHELGHSFGIQHDGSGNDCEPVGKRPF-IMSPQLLYDAAPLTWSRCSRQYITRFLD 441
Query: 458 SGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCK-YGEVCRELWCLSKS 516
G G CLD+ P K +P+V PG +YD QCR QYGA S C+ VC LWC S
Sbjct: 442 RGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWC-SVG 500
Query: 517 NRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGG 576
C + A +GT C E WC G+CVP G P+++DGGW WS W CSR+CG
Sbjct: 501 TTCHSKLDAAVDGTRCG----ENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGM 556
Query: 577 GVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKY 636
GV S+ R C P P G+YC+GERKR+R CN CP G FR QC+ FD M ++G+
Sbjct: 557 GVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQL 616
Query: 637 YNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNA--DSLDICINGECKHVGCD 694
+ W P V PC L+C F + AV+DGT C S D+CING CK+VGCD
Sbjct: 617 HTWVPVVND-VNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCD 675
Query: 695 NILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSK 754
+ S A EDRC VC G+GSTC + G F ++ G Y++V IP G+ I ++EVA +
Sbjct: 676 FEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLG-YVDVGLIPAGAREIRIQEVAEAA 734
Query: 755 NYIALKSEGDD-YYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMV 813
N++AL+SE + Y++NG WTI W + VAGT F Y R + E+L + GPT E + + +
Sbjct: 735 NFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNW-ENLTSPGPTKEPVWIQL 793
Query: 814 LLQEQNLGIRYKFNVPITRTGSGDNEVG---FTWNHQPWSECSATCAGGVQRQEVVCKRL 870
L QE N G+ Y++ I R G +EV F+W++ PW++C+ TC GVQRQ V C
Sbjct: 794 LFQESNPGVHYEYT--IHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLER 851
Query: 871 DDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCD-GGMRTRAVLCIRK 929
V +CDP +P + QR C+ +PCP W+ G+W CS +C GG+ RAVLCIR
Sbjct: 852 QAGP-VDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRS 910
Query: 930 IGPSEEETLDYSGCL-THRPVEKEPCNNQ-SCPPQWVALDWSECTPKCGPGFKHRIVLCK 987
+G E+ L+ C RP + PCN CP W +WS+C+ CG G + R VLC
Sbjct: 911 VGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCT 970
Query: 988 SSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWG 1028
+ C E +P + CSL C RW G G
Sbjct: 971 NDT------GVPCDEAQQPASEVTCSLPLC---RWPLGTLG 1002
Score = 127 bits (320), Expect = 5e-29
Identities = 84/277 (30%), Positives = 114/277 (41%), Gaps = 29/277 (10%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
W WSECS TC G + V C D C P + P+ R C+ PC W
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGR-PQPARRCHLRPC-ATW 1466
Query: 904 FIGDWLECSKTCDGGMRTRAVLCI--RKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPP 961
G+W +CS++C GG R V C+ R + P +P PC Q C
Sbjct: 1467 HSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPA---KPPAHRPCGAQPC-L 1522
Query: 962 QWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPR 1021
W W EC+ CG G + R+V C L C E +P C+ C +
Sbjct: 1523 SWYTSSWRECSEACGGGEQQRLVTCPEPGL--------CEEALRPNTTRPCNTHPC--TQ 1572
Query: 1022 WVTGDWGQCSAQCGLGQQMRTVQCL-SYTG---QASSDCLETVRPPSMQQCESKCDSTPI 1077
WV G WGQCS CG G Q R V+C+ + TG + S C P S + C ++ D P+
Sbjct: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTE-DCEPV 1631
Query: 1078 SNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
+D +C + C R CC++C
Sbjct: 1632 EPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSC 1668
Score = 102 bits (253), Expect = 3e-21
Identities = 69/229 (30%), Positives = 97/229 (42%), Gaps = 28/229 (12%)
Query: 843 TWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPE 902
TW+ WS+CS +C GG ++V C D ++ +C P P R C +PC
Sbjct: 1465 TWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC-LS 1523
Query: 903 WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQ 962
W+ W ECS+ C GG + R V C + G EE RP PCN C Q
Sbjct: 1524 WYTSSWRECSEACGGGEQQRLVTC-PEPGLCEEAL---------RPNTTRPCNTHPC-TQ 1572
Query: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLS-KTFPAAQCPEESKPPVRIRCSLGRC---P 1018
WV W +C+ CG G + R+V C ++ + QC E+ P C C
Sbjct: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVE 1632
Query: 1019 PPRWVTG--DWGQCSAQCGLGQ-QMRTVQCLSYTGQASSDCLETVRPPS 1064
PPR +G C LG+ Q+ T++ + C + PPS
Sbjct: 1633 PPRCERDRLSFGFCETLRLLGRCQLPTIR---------TQCCRSCSPPS 1672
Score = 34.3 bits (77), Expect = 0.68
Identities = 20/48 (41%), Positives = 21/48 (43%), Gaps = 4/48 (8%)
Query: 565 SLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPC 612
S W ECS CGGG L C P G + L R CNT PC
Sbjct: 1527 SSWRECSEACGGGEQQRLVTCPEP---GLCEEAL-RPNTTRPCNTHPC 1570
Score = 32.7 bits (73), Expect = 2.0
Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 5/51 (9%)
Query: 567 WGECSRTCGGGVSSSLRHC---DSPAPSGGGKYCLGER--KRYRSCNTDPC 612
WG+CS CGGGV L C + P C E + R C T+ C
Sbjct: 1578 WGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 32.3 bits (72), Expect = 2.6
Identities = 37/135 (27%), Positives = 49/135 (36%), Gaps = 23/135 (17%)
Query: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC--LGERKRYRSCNTDPCPL- 614
+ GW + W ECS TCG G C SG + C G + R C+ PC
Sbjct: 1412 NAGWQAGN-WSECSTTCGLGAVWRPVRCS----SGRDEDCAPAGRPQPARRCHLRPCATW 1466
Query: 615 -------------GSRDFREKQCADF-DNMPFRGKYYNWKPYTGGGVKPC-ALNCLAEGY 659
G R+ QC D D P R + P +PC A CL+
Sbjct: 1467 HSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYT 1526
Query: 660 NFYTERAPAVIDGTQ 674
+ + E + A G Q
Sbjct: 1527 SSWRECSEACGGGEQ 1541
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 745 bits (1923), Expect = 0.0
Identities = 410/1085 (37%), Positives = 587/1085 (54%), Gaps = 107/1085 (9%)
Query: 42 YQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLT 101
Y L VD G ++S + + H RRRR++ P V L +L FH++L
Sbjct: 60 YDLVSAYEVDHRGDYVSHEIMH--HQRRRRAV----PVSEVESLHLRLKGSRHDFHMDLR 113
Query: 102 LNTDFVSKHFTVEYWGKDGPQWKHDFL--DNCHYTGYLQDQRSTTKVALSNCVGLHGVIA 159
++ V+ F V+ GK G + D C Y G L+ R+++ VALS C GL G+I
Sbjct: 114 TSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSS-VALSTCQGLSGMIR 172
Query: 160 TEDEEYFIEPLKNTTEDSKHFSYENGHP-------HVIYKKSALQQRHLYDHSHC-GVSD 211
TE+ +YF+ PL + H S++ G HV+YK+S H G S+
Sbjct: 173 TEEADYFLRPLPS------HLSWKLGRAAQGSSPSHVLYKRST--------EPHAPGASE 218
Query: 212 FTRSGKPWWLNDTSTVSYSLPINNTHIHH----------------------------RQK 243
+ + W L S L + H R K
Sbjct: 219 VLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHK 278
Query: 244 RSV-----SIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNII 298
RS+ + E VETLVV DK M+ HG ++I Y+L+++N+V+ L++D ++G +NI
Sbjct: 279 RSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIA 338
Query: 299 VARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITR 358
+ LI+L ++QP L I+HHAD +L SFC+WQ ++ DG HD+A+L+T
Sbjct: 339 IVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMG--KDGT--------RHDHAILLTG 388
Query: 359 YDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGN 418
DIC++KN+PC TLG A ++GMC RSC+INED GLG AFTIAHE GHNFGM HDG GN
Sbjct: 389 LDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGN 448
Query: 419 SCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEP-PKRDFLYPA 477
C +M+ + FSWS CSR Y+ FL + + CL ++P P +++ YP
Sbjct: 449 MCKKS---EGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPE 505
Query: 478 VAPGQVYDADEQCRFQYGATSRQCKYG---EVCRELWCLSKSNRCVTNSIPAAEGTLCQT 534
PG++YDA+ QC++Q+G ++ C ++C+ LWC +C T +PAAEGT+C
Sbjct: 506 KLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICG- 564
Query: 535 GNIEKGWCYQGDCVPFGT-WPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGG 593
WC G CV +G P+ G W WS W CSRTCGGGVS R C +P PS G
Sbjct: 565 ---HDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
Query: 594 GKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKP-CAL 652
GK+C G + + CN+ CP S DFR QCA+ ++ FRG++Y WKPYT + C L
Sbjct: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKL 681
Query: 653 NCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGD 712
C+AEG++F+ + V DGT C+ DS ++CI+G C+ VGCDN+LGSDA ED C VC G+
Sbjct: 682 YCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGN 741
Query: 713 GSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAW 772
S C G + Y +V IP G+ I + E+ +S +YI++++ YY+NG W
Sbjct: 742 NSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHW 801
Query: 773 TIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITR 832
T+DWP ++ +GT F Y+R +EPE+L A GPT+E LIV +L Q +N G+ +++++P R
Sbjct: 802 TVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMP--R 859
Query: 833 TGSGDN---EVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPE 889
G+ + +TW SECS +C GG C R D V ++C+P ++P
Sbjct: 860 LGTEKQPPAQPSYTWAIVR-SECSVSCGGGQMTVREGCYR-DLKFQVNMSFCNPKTRPVT 917
Query: 890 NQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPV 949
C CPP W +G+W CS+TC GG ++R V C R++ + E + S C P
Sbjct: 918 GLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRV-HYDSEPVPASLCPQPAPS 976
Query: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLS---KTFPAAQCPEESKP 1006
++ CN+QSCPP W A W+EC+ CG G++ R V CKS++ S + P A C E KP
Sbjct: 977 SRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKP 1036
Query: 1007 PVRIRCSLGRCPPPR---WVTGDWGQCSAQCGLGQQMRTVQCL------SYTGQASSDCL 1057
+ C L RC P+ W+ W QCS C G Q R ++C Y AS C
Sbjct: 1037 RMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCS 1096
Query: 1058 ETVRP 1062
+P
Sbjct: 1097 HLPKP 1101
Score = 50.4 bits (119), Expect = 9e-06
Identities = 39/122 (31%), Positives = 53/122 (43%), Gaps = 13/122 (10%)
Query: 960 PPQWVALDW----SECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVR-IRCSL 1014
PP + W SEC+ CG G C DL + C +++P + C +
Sbjct: 866 PPAQPSYTWAIVRSECSVSCGGGQMTVREGCYR-DLKFQVNMSFCNPKTRPVTGLVPCKV 924
Query: 1015 GRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC---LSYTGQ--ASSDCLETVRPPSMQQCE 1069
CPP W G+W CS CG G Q R VQC + Y + +S C + P S Q C
Sbjct: 925 SACPPS-WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPA-PSSRQACN 982
Query: 1070 SK 1071
S+
Sbjct: 983 SQ 984
Score = 40.4 bits (93), Expect = 0.009
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 11/61 (18%)
Query: 843 TWNHQPWSECSATCAGGVQRQEVVC---KRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
+W PWS+C+A+C GGVQ + V C R ++ + P ACNT C
Sbjct: 1129 SWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLH--------QKPSASLACNTHFC 1180
Query: 900 P 900
P
Sbjct: 1181 P 1181
Score = 38.1 bits (87), Expect = 0.047
Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 8/70 (11%)
Query: 562 GPW--SLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRS--CNTDPCPLGSR 617
G W S W +C+ +CGGGV + C + G CL +K S CNT CP+ +
Sbjct: 1128 GSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG--CLLHQKPSASLACNTHFCPIAEK 1185
Query: 618 DFREKQCADF 627
++ C D+
Sbjct: 1186 --KDAFCKDY 1193
Score = 32.7 bits (73), Expect = 2.0
Identities = 31/108 (28%), Positives = 42/108 (38%), Gaps = 22/108 (20%)
Query: 565 SLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQC 624
S W +CS TC G C KY G+ + S P S + E+ C
Sbjct: 1058 SAWSQCSVTCERGTQKRFLKCAE-------KYVSGKYRELASKKCSHLPKPSLEL-ERAC 1109
Query: 625 ADFD---NMPF------RGKYYN--WKPYT---GGGVKPCALNCLAEG 658
A + PF RG ++ W T GGGV+ ++ CLA G
Sbjct: 1110 APLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGG 1157
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 720 bits (1859), Expect = 0.0
Identities = 401/1005 (39%), Positives = 564/1005 (56%), Gaps = 57/1005 (5%)
Query: 32 QEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKND-KHSRRRRSMDPIDPQQAVSKLFFKLS 90
QE F+ L Y + P+RVD +G FLS+ + SRR+R +D + +++++S
Sbjct: 42 QEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW-----VYYRIS 96
Query: 91 AYGKHFHLNLTLNTDFVSKHFTVE--YWGKDGPQWKHDFLDNCHYTG-YLQDQRSTTKVA 147
K NLT+N F+S + +E Y + CH +G LQ A
Sbjct: 97 HEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAA 156
Query: 148 LSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENG-HPHVIYKKSALQQRHLYDHSH 206
LS C GL G ++FIEP+K KH E G HPH++Y++ + +
Sbjct: 157 LSACHGLTGFFQLPHGDFFIEPVK------KHPLVEGGYHPHIVYRRQKVPETK---EPT 207
Query: 207 CGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYH 266
CG+ D + L ++LP + +RS+S ER+VETLVVAD M+ YH
Sbjct: 208 CGLKDSVNISQKQELWREKWERHNLPSRSL-----SRRSISKERWVETLVVADTKMIEYH 262
Query: 267 GRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFC 326
G +++E YIL++MN+V L+ + S+GN ++I+V RLI+L E++ L+I HHA+K+L SFC
Sbjct: 263 GSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFC 322
Query: 327 KWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERS 386
KWQKSI + +SD N + HHD AVL+TR DIC N+PC TLGL+ ++GMC+P RS
Sbjct: 323 KWQKSI-NPKSDLNPV------HHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRS 375
Query: 387 CSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSA 446
C+INED GL AFTIAHE+GH+FG+ HDG N C G +M+ + + P +WS
Sbjct: 376 CNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPY-IMSRQLQYDPTPLTWSK 434
Query: 447 CSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGE- 505
CS +YIT FLD G G CLD+ P K+ +APG +YD QC+ QYG + C+ E
Sbjct: 435 CSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVEN 494
Query: 506 VCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWS 565
VC+ LWC S C + AA+GT C EK WC G C+ G P+SI GGWG WS
Sbjct: 495 VCQTLWC-SVKGFCRSKLDAAADGTQCG----EKKWCMAGKCITVGKKPESIPGGWGRWS 549
Query: 566 LWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCA 625
W CSRTCG GV S+ R C++P P GGKYC GERKRYR CN PC + FR+ QC+
Sbjct: 550 PWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCS 609
Query: 626 DFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQC--NADSLDIC 683
+FD +P++ + Y+W P PC L C F + AVIDGT C +S ++C
Sbjct: 610 EFDTVPYKNELYHWFPIF-NPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVC 668
Query: 684 INGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSV 743
ING CK VGCD + S+A EDRC VC GDGS+C + F GY+++ IP+G+
Sbjct: 669 INGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQK-EGSGYVDIGLIPKGAR 727
Query: 744 HIEVREVAMSKNYIALKSEG-DDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEAL 802
I V E+ + N++A++SE + YY+NG + I W + +AGT F Y R D E L A
Sbjct: 728 DIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGD-LEKLMAT 786
Query: 803 GPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATCAGGVQR 862
GPT+E++ + +L Q N GI+Y++ + + + + W + W+ECS TC G++R
Sbjct: 787 GPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRR 846
Query: 863 QEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTC-DGGMRT 921
Q C + +V+ +CDP+++P Q+ C+ + CPP W+ G+W CS TC G +
Sbjct: 847 QTAHCIK-KGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKK 905
Query: 922 RAVLCIRKIGPSEEETLDYSGCL-THRPVEKEPCNNQ-SCPPQWVALDWSECTPKCGPGF 979
R VLCI+ + S+E+ L + C +P CN CP W +WSEC+ CG G
Sbjct: 906 RTVLCIQTM-VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGV 964
Query: 980 KHRIVLC-KSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
+ R V C K+ D C KP R C L +CP R V
Sbjct: 965 RIRSVTCAKNHD-------EPCDVTRKPNSRALCGLQQCPSSRRV 1002
Score = 124 bits (312), Expect = 4e-28
Identities = 79/277 (28%), Positives = 110/277 (39%), Gaps = 28/277 (10%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
W WSECS TC G + V C D+ DP + C+ PC W
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKR-------CHLRPCAG-W 1368
Query: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
+G+W +CS+ C GG + R + C+ P CN + C W
Sbjct: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA-W 1427
Query: 964 VALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
WS+C+ CG G + R V C P C +P + C+ C W
Sbjct: 1428 QVEPWSQCSRSCGGGVQERGVFC---------PGGLCDWTKRPTSTMSCNEHLCC--HWA 1476
Query: 1024 TGDWGQCSAQCGLGQQMRTVQCLSYTGQASSD-----CLETVRPPSMQQC-ESKCDSTPI 1077
TG+W CS CG G Q RTVQC+ G + D C RPP ++C + C +
Sbjct: 1477 TGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKS-- 1534
Query: 1078 SNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
++ KD ++C + K CS R CC +C
Sbjct: 1535 ADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 1/70 (1%)
Query: 831 TRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKP-PE 889
T T S + + W W CS +C GG Q++ V C + N + C D KP P
Sbjct: 1462 TSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPP 1521
Query: 890 NQRACNTEPC 899
+ CN + C
Sbjct: 1522 EFKKCNQQAC 1531
Score = 30.8 bits (68), Expect = 7.5
Identities = 18/55 (32%), Positives = 22/55 (40%), Gaps = 12/55 (21%)
Query: 567 WGECSRTCGGGVSSSLRHCDSPAPSGGGK-----YCLGERK----RYRSCNTDPC 612
W CS +CGGG C PS G K CL + K ++ CN C
Sbjct: 1480 WDLCSTSCGGGFQKRTVQC---VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 650 bits (1676), Expect = 0.0
Identities = 410/1126 (36%), Positives = 578/1126 (51%), Gaps = 118/1126 (10%)
Query: 32 QEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPI-DPQQAV-------- 82
Q + L L Y++ PIRV+ G V R RRS++ DP A
Sbjct: 38 QVKLLETLSEYEIVSPIRVNALGEPFPTNVH---FKRTRRSINSATDPWPAFASSSSSST 94
Query: 83 -SKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDF------LDNCHYTG 135
S+ ++LSA+G+ F NLT N F++ FTV G G + L +C Y G
Sbjct: 95 SSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKG 154
Query: 136 YLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSA 195
Y+ T V +S C G+ G + D +YFIEPL++ D + E PH+IY++SA
Sbjct: 155 YVNTNSEHTAV-ISLCSGMLGTFRSHDGDYFIEPLQSM--DEQEDEEEQNKPHIIYRRSA 211
Query: 196 LQQ-----RHLYDHS-----HCGVSDFTRSGKPWW------------LND-TSTVSYSLP 232
Q+ RH D S H TR+ K W LN +T ++S
Sbjct: 212 PQREPSTGRHACDTSEHKNRHSKDKKKTRARK--WGERINLAGDVAALNSGLATEAFSAY 269
Query: 233 INNT------HIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLY 286
N T H R KR +S RFVE LVVAD MV YHG ++++HYIL++M+IVA +Y
Sbjct: 270 GNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIY 328
Query: 287 RDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENG 346
+D S+GN++NI++ LIV+ +Q I+ +A +L +FC+WQ S S G
Sbjct: 329 KDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSP----------G 378
Query: 347 IAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIG 406
HHD AVL+TR DIC +K C TLGLA + +C+P RSCSI+ED GL +AFTIAHE+G
Sbjct: 379 GIHHDTAVLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELG 437
Query: 407 HNFGMNHDGIGNSCGTKGHEAAK-LMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLD 465
H F M HD N C +G ++ + +MA + TNP+ WS CSR YIT FLD+G G CL
Sbjct: 438 HVFNMPHDD-NNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 496
Query: 466 NEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSN---RCVTN 522
NEP R + P PG +Y+ ++QC +G S+ C Y CR LWC + + C T
Sbjct: 497 NEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQ 556
Query: 523 SIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSL 582
P A+GT C+ G C G CVP DG WG WS +G CSRTCGGG+ +++
Sbjct: 557 HTPWADGTECEPGK----HCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAI 612
Query: 583 RHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYN---- 638
R C+ P P GGKYC+G R +++SCNT+PC RDFR++QCA FD GK++N
Sbjct: 613 RECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFD-----GKHFNINGL 667
Query: 639 -----WKP-YTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHV 691
W P Y+G +K C L C G Y + VIDGT C D+ DIC+ G C+
Sbjct: 668 LPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQA 727
Query: 692 GCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVA 751
GCD++L S AR D+C VCGGD S+C + G FN GY VV+IP G+ +I+VR+ +
Sbjct: 728 GCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFN--TVHYGYNTVVRIPAGATNIDVRQHS 785
Query: 752 MS-----KNYIALKSEGDDYYINGAWTIDW-PRKFDVAGTAFHYKRPTDEPESLEALGPT 805
S NY+AL S ++ +NG + + R+ + Y E + +
Sbjct: 786 FSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRI 845
Query: 806 SENLIVMVLL--QEQNLGIRYKFNVPITRTGSGDNEVGFTWN-HQPWSECSATCAGGVQR 862
+ L++ VL + N +RY FN+PI D F WN H PW CS C G ++
Sbjct: 846 EQELLLQVLSVGKLYNPDVRYSFNIPIE-----DKPQQFYWNSHGPWQACSKPCQ-GERK 899
Query: 863 QEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTR 922
+++VC R D V + CD +P C T+ C W + ECS C G RT
Sbjct: 900 RKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTL 958
Query: 923 AVLCIRKIG-PSEEETLDYSGCLTH-RPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFK 980
+ C + + E +D C +H +P +E C+ + W W+EC+ C G +
Sbjct: 959 DIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQ 1018
Query: 981 HRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQM 1040
R +C ++ + ++C + K ++ RCS P P+W +GDW +C CG G +
Sbjct: 1019 RRRAICVNT-RNDVLDDSKCTHQEKVTIQ-RCS--EFPCPQWKSGDWSECLVTCGKGHKH 1074
Query: 1041 RTVQCLSYTGQASSD--CLETVRPPSMQQCES-KCDSTPISNTEEC 1083
R V C + +D C +P SMQ C+ +C S +C
Sbjct: 1075 RQVWC-QFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQC 1119
Score = 167 bits (424), Expect = 4e-41
Identities = 105/278 (37%), Positives = 134/278 (48%), Gaps = 39/278 (14%)
Query: 841 GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
G W PW CS+TCAGG QR+ VVC+ D+N N+ C KP E QRAC + PCP
Sbjct: 1329 GNQWRTGPWGACSSTCAGGSQRRVVVCQ--DENGYTAND-CVERIKPDE-QRACESGPCP 1384
Query: 901 PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP 960
+W G+W EC+K C GG+RTR V+C R G E D S + +P ++E CN +CP
Sbjct: 1385 -QWAYGNWGECTKLCGGGIRTRLVVCQRSNG---ERFPDLSCEILDKPPDREQCNTHACP 1440
Query: 961 --PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
W WS C+ CG G K R V C + D S + C +KP +C GRC
Sbjct: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSH-LESDYCKHLAKPHGHRKCRGGRC- 1498
Query: 1019 PPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS--SDCLETVRPPSMQQCESKCDSTP 1076
P+W G W QCS CG G Q R V C T + + ++C RP S + C+
Sbjct: 1499 -PKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQG------ 1551
Query: 1077 ISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
CPL + RA Q C KTC
Sbjct: 1552 -------------PRCPL-----YTWRAEEWQECTKTC 1571
Score = 150 bits (380), Expect = 5e-36
Identities = 83/249 (33%), Positives = 124/249 (49%), Gaps = 14/249 (5%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP-E 902
W WS+CS +C GVQ++ V C+ + + I + C+P ++P E++R C CP
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQ-IGTHKIARETECNPYTRP-ESERDCQGPRCPLYT 1558
Query: 903 WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQ 962
W +W EC+KTC G R R V+C+ ++ E ++ RPV++E C+ Q C
Sbjct: 1559 WRAEEWQECTKTCGEGSRYRKVVCV---DDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
Query: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKT------FPAAQCPEESKPPVRIRCSLGR 1016
W+ +WSEC+ CG G+K R+V C K CP ++PP C L
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP-GTQPPSVHPCYLRD 1674
Query: 1017 CP-PPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDST 1075
CP W G+WG CS CG+G R+VQCL+ Q S C ++P + C + +
Sbjct: 1675 CPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCE 1734
Query: 1076 PISNTEECK 1084
N +E K
Sbjct: 1735 LPQNCKEVK 1743
Score = 142 bits (359), Expect = 1e-33
Identities = 92/291 (31%), Positives = 121/291 (41%), Gaps = 56/291 (19%)
Query: 843 TWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQR----ACNTEP 898
+W PW +CS TC G Q + V C S+V +N C+ ++P + Q +C+ P
Sbjct: 1110 SWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPP 1169
Query: 899 CPPE------------WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLT- 945
PE W G W CS TC G R R V C + G +E S C T
Sbjct: 1170 AAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADE----SACATL 1225
Query: 946 HRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESK 1005
RPV KE C+ C QW ALDWS C+ CG G R V+C + ++C ++
Sbjct: 1226 PRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCVNYS-DHVIDRSECDQDYI 1283
Query: 1006 PPVRIRCSLGRCPP------------------PR--------------WVTGDWGQCSAQ 1033
P CS+ CP PR W TG WG CS+
Sbjct: 1284 PETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSST 1343
Query: 1034 CGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCES-KCDSTPISNTEEC 1083
C G Q R V C G ++DC+E ++P + CES C N EC
Sbjct: 1344 CAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGEC 1394
Score = 141 bits (356), Expect = 3e-33
Identities = 82/233 (35%), Positives = 108/233 (46%), Gaps = 17/233 (7%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVC---KRLDDNSI-VQNNYCDPDSKPPENQRACNTEPC 899
W+ SECSA C G + ++ C RLD + V + +C KP N+ C+ E
Sbjct: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP-SNREKCSGECN 997
Query: 900 PPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSC 959
W W ECSK+CDGG + R +C+ + + LD S C V + C+ C
Sbjct: 998 TGGWRYSAWTECSKSCDGGTQRRRAICVN----TRNDVLDDSKCTHQEKVTIQRCSEFPC 1053
Query: 960 PPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPP 1019
P QW + DWSEC CG G KHR V C+ + C E+KP C C
Sbjct: 1054 P-QWKSGDWSECLVTCGKGHKHRQVWCQFGE--DRLNDRMCDPETKPTSMQTCQQPECAS 1110
Query: 1020 PRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA---SSDCLETVRPPSMQQCE 1069
W G WGQCS CG G Q+R V+C+ T + +DC RP Q CE
Sbjct: 1111 --WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCE 1161
Score = 120 bits (301), Expect = 7e-27
Identities = 76/253 (30%), Positives = 107/253 (42%), Gaps = 30/253 (11%)
Query: 835 SGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRAC 894
SG+ G W + W+ECS +C GG QR+ +C N ++ ++ C K + C
Sbjct: 993 SGECNTG-GWRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEKVTIQR--C 1048
Query: 895 NTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTH-RPVEKEP 953
+ PCP +W GDW EC TC G + R V C + G E+ L+ C +P +
Sbjct: 1049 SEFPCP-QWKSGDWSECLVTCGKGHKHRQVWC--QFG---EDRLNDRMCDPETKPTSMQT 1102
Query: 954 CNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCS 1013
C C W A W +C+ CG G++ R V C C ++P C
Sbjct: 1103 CQQPECA-SWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCE 1161
Query: 1014 LGRCPPP----------------RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS--SD 1055
L C PP +W G W CSA CG G +MR V C G + S
Sbjct: 1162 LPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESA 1221
Query: 1056 CLETVRPPSMQQC 1068
C RP + ++C
Sbjct: 1222 CATLPRPVAKEEC 1234
Score = 101 bits (252), Expect = 3e-21
Identities = 58/177 (32%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 842 FTWNHQPWSECSATCAGGVQRQEVVCKRLDDN-SIVQNNYCDPDSKPPENQRACNTEPCP 900
+TW + W EC+ TC G + ++VVC +DDN + V CD SK P ++ +C+ +PC
Sbjct: 1557 YTWRAEEWQECTKTCGEGSRYRKVVC--VDDNKNEVHGARCDV-SKRPVDRESCSLQPCE 1613
Query: 901 PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYS---GCLTHRPVEKEPCNNQ 957
W G+W ECS TC G + R V C E Y C +P PC +
Sbjct: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
Query: 958 SCP--PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRC 1012
CP W +W C+ CG G R V C +++ P+ C + KP R C
Sbjct: 1674 DCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNE---DQPSHLCHTDLKPEERKTC 1727
Score = 56.2 bits (134), Expect = 2e-07
Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 13/135 (9%)
Query: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRL-----DDNSIVQNNYCDP 883
P+ R + W WSECS TC G +++ V C + + Q P
Sbjct: 1601 PVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP 1660
Query: 884 DSKPPENQRACNTEPCP--PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYS 941
++PP + C CP W +G+W CS +C G+ R+V C+ + E+ +
Sbjct: 1661 GTQPP-SVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL-----TNEDQPSHL 1714
Query: 942 GCLTHRPVEKEPCNN 956
+P E++ C N
Sbjct: 1715 CHTDLKPEERKTCRN 1729
Score = 38.9 bits (89), Expect = 0.028
Identities = 52/219 (23%), Positives = 75/219 (34%), Gaps = 49/219 (22%)
Query: 418 NSCG-TKGHEAAKLMAAHITANTNPFSWSACSRDYITSF-LDSGRGTCLDNEPPK----- 470
+SC T G A + + + S C +DYI D C P
Sbjct: 1248 SSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQH 1307
Query: 471 ----RDFLYPAVAPGQ--VYDADEQCRFQYGATSRQCKYGEVCRELWCLSKS----NRCV 520
D+ + +P + V ++ +GA S C G R + C ++ N CV
Sbjct: 1308 PFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCV 1367
Query: 521 TNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSS 580
P E+ C G C PQ G WG EC++ CGGG+ +
Sbjct: 1368 ERIKPD-----------EQRACESGPC------PQWAYGNWG------ECTKLCGGGIRT 1404
Query: 581 SLRHCDSPAPSGGGKY------CLGERKRYRSCNTDPCP 613
L C S G ++ L + CNT CP
Sbjct: 1405 RLVVCQR---SNGERFPDLSCEILDKPPDREQCNTHACP 1440
Score = 31.2 bits (69), Expect = 5.7
Identities = 22/78 (28%), Positives = 29/78 (37%), Gaps = 20/78 (25%)
Query: 501 CKYGEVCRELWCLSKSNRCVTNSI-PAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDG 559
C G R++WC +R P + T QT C Q +C + P
Sbjct: 1068 CGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQT-------CQQPECASWQAGP----- 1115
Query: 560 GWGPWSLWGECSRTCGGG 577
WG+CS TCG G
Sbjct: 1116 -------WGQCSVTCGQG 1126
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 618 bits (1593), Expect = e-176
Identities = 392/1172 (33%), Positives = 589/1172 (50%), Gaps = 156/1172 (13%)
Query: 5 WKT-LTWILSLIMASS---EFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT 60
W T L + LSL + S +FH QE + L Y++ IP RV++ G
Sbjct: 6 WLTGLLYHLSLFITRSWEVDFHP-------RQEALVRTLTSYEVVIPERVNEFGEVFP-- 56
Query: 61 VKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGK-D 119
++ SR++RS + ++P + ++ +AYG+ F LNLT + F++ +T + G +
Sbjct: 57 -QSHHFSRQKRSSEALEPMPF--RTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPE 113
Query: 120 GPQWKHDF----LDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTE 175
W+ D L +C Y G + Q K +S C GL G ++ EYF+EP+
Sbjct: 114 RGAWESDAGPSDLRHCFYRGQVNSQEDY-KAVVSLCGGLTGTFKGQNGEYFLEPIMKADG 172
Query: 176 DSKHFSYENGH--PHVIYKKSALQQRHLYDHSHCGVSD--FTRSGKPWW----LNDTSTV 227
+ YE+GH PH+IY++ L L +C VS+ + P+ +N+ V
Sbjct: 173 NE----YEDGHNKPHLIYRQD-LNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNV 227
Query: 228 ---------SYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSV 278
S ++P+ + H R+KR +S R++E +V AD +V HG ++++YIL++
Sbjct: 228 MKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHG-SNLQNYILTL 286
Query: 279 MNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSD 338
M+IVA +Y+D S+GN+++I+V +L+++ ++ IN +L +FC WQ++
Sbjct: 287 MSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQT------- 339
Query: 339 GNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSA 398
N + + +HHD AVLITR DIC+ K K C LGL+ + +C+P +SC INE+ GL SA
Sbjct: 340 QNDLDDVHPSHHDTAVLITREDICSSKEK-CNMLGLSYLGTICDPLQSCFINEEKGLISA 398
Query: 399 FTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDS 458
FTIAHE+GH G+ HD C +MA ++ + +P+SWS CSR Y+T FLD+
Sbjct: 399 FTIAHELGHTLGVQHDD-NPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDT 457
Query: 459 GRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNR 518
G G CL ++P + + P+ PG YD ++QC +G S+ C + +C LWC S
Sbjct: 458 GYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKL 517
Query: 519 ---CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCG 575
C T +P A+GT C G C G CV T + ++G WGPW + CSRTCG
Sbjct: 518 HKGCFTQHVPPADGTDCGPGM----HCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCG 573
Query: 576 GGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFD--NMPFR 633
GG+ S+ R C+ P P GG YC+G R ++RSCNTD CP G++DFREKQC+DF+ ++
Sbjct: 574 GGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDIS 633
Query: 634 GKYYN--WKP-YTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECK 689
G N W P Y+G G K C L C G N++ V DGT C ++ DIC+ G+C
Sbjct: 634 GIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCM 693
Query: 690 HVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVRE 749
GCD++L S A+ D+C VCGGD S+C I G FN S GY VV+IP G+ ++++R+
Sbjct: 694 AAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSS--HYGYNVVVKIPAGATNVDIRQ 751
Query: 750 VAMS----KNYIALKSEGDDYYINGAWTIDWPRK-FDVAG--TAFHYKRPTDEPESLEAL 802
+ S +Y+AL ++ NG + + +K +V G T Y + E + +
Sbjct: 752 YSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINST 811
Query: 803 GPTSENLIVMVLL--QEQNLGIRYKFNVPITRTGSGDNEVGFTWN-HQPWSECSATCAGG 859
+ LI+ VL N + Y FN+P+ + FTW+ + PW C+ C G
Sbjct: 812 NRQEKELILQVLCVGNLYNPDVHYSFNIPLE-----ERSDMFTWDPYGPWEGCTKMCQ-G 865
Query: 860 VQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGM 919
+QR+ + C D+S+V + CD P ++CNT+ C W + ECS C G
Sbjct: 866 LQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGY 924
Query: 920 RTRAVLCIR------------------KIGPSEEETL------------DYSGC------ 943
RT + C++ ++ P +E ++S C
Sbjct: 925 RTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGG 984
Query: 944 ------------LTHRPVEKE----------PCNNQSCPPQWVALDWSECTPKCGPGFKH 981
HR + E CN SC P W A +WSEC CG G K
Sbjct: 985 GERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSC-PSWAASEWSECLVTCGKGTKQ 1043
Query: 982 RIVLCKSS--DLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQ 1039
R V C+ + LS F C +KP C L C W G WG C+ CG G Q
Sbjct: 1044 RQVWCQLNVDHLSDGF----CNSSTKPESLSPCELHTC--ASWQVGPWGPCTTTCGHGYQ 1097
Query: 1040 MRTVQCLSYTGQA---SSDCLETVRPPSMQQC 1068
MR V+C++ A ++C E RP Q C
Sbjct: 1098 MRDVKCVNELASAVLEDTECHEASRPSDRQSC 1129
Score = 157 bits (396), Expect = 7e-38
Identities = 89/256 (34%), Positives = 131/256 (51%), Gaps = 22/256 (8%)
Query: 827 NVPIT-RTGSGDNEV------GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNN 879
N+P+T + +N+V G W PW CS++C+GG+Q + VVC+ D + +
Sbjct: 1284 NLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ---DENGQSAS 1340
Query: 880 YCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLD 939
YCD SKPPE Q+ C PCP +W G+W ECS+TC GG+++R V+C P+ + D
Sbjct: 1341 YCDAASKPPELQQ-CGPGPCP-QWNYGNWGECSQTCGGGIKSRLVIC---QFPNGQILED 1395
Query: 940 YSGCLTHRPVEKEPCNNQSCPP--QWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPA 997
++ + ++P C+ +CP W W+ C+ CG G K+R V C +
Sbjct: 1396 HNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFC-IDQFQRKLED 1454
Query: 998 AQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC-LSYTGQASSD- 1055
C + KPP C RC P W W +CS CG G Q R V C L GQ +
Sbjct: 1455 TNCSQVQKPPTHKACRSVRC--PSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEM 1512
Query: 1056 CLETVRPPSMQQCESK 1071
C ++ RP S ++C S+
Sbjct: 1513 CDQSTRPCSQRRCWSQ 1528
Score = 116 bits (291), Expect = 1e-25
Identities = 81/300 (27%), Positives = 113/300 (37%), Gaps = 67/300 (22%)
Query: 843 TWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP-- 900
+W PW C+ TC G Q ++V C ++++++ C S+P + Q +C PC
Sbjct: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQ-SCVLTPCSFI 1137
Query: 901 ----------------PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL 944
+W G W CS +C G + R V C + + D S C
Sbjct: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDAL----DRIADESYC- 1192
Query: 945 THRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEES 1004
H P E + + +W A DWS C+ CG G R VLC + + C E
Sbjct: 1193 AHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMN--YHQPIDENYCDPEV 1250
Query: 1005 KPPVRIRCSLGRCPPP----------------------------------------RWVT 1024
+P + CSL CPP +W T
Sbjct: 1251 RPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRT 1310
Query: 1025 GDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQC-ESKCDSTPISNTEEC 1083
G WG CS+ C G Q R V C GQ++S C +PP +QQC C N EC
Sbjct: 1311 GPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGEC 1370
Score = 110 bits (275), Expect = 7e-24
Identities = 73/274 (26%), Positives = 102/274 (37%), Gaps = 28/274 (10%)
Query: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPP 888
P T+ N V W++ WS+CS +C GG + +E C + + N +
Sbjct: 955 PPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTR 1014
Query: 889 ENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRP 948
EN CN CP W +W EC TC G + R V C + + + S +P
Sbjct: 1015 EN---CNEFSCP-SWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSST----KP 1066
Query: 949 VEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPV 1008
PC +C W W CT CG G++ R V C + S +C E S+P
Sbjct: 1067 ESLSPCELHTCA-SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD 1125
Query: 1009 RIRCSLGRC-----------------PPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQ 1051
R C L C +W G W CS CG G Q R V C +
Sbjct: 1126 RQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDR 1185
Query: 1052 ASSD--CLETVRPPSMQQCESKCDSTPISNTEEC 1083
+ + C RP + C + C + C
Sbjct: 1186 IADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPC 1219
Score = 107 bits (266), Expect = 8e-23
Identities = 78/307 (25%), Positives = 119/307 (38%), Gaps = 71/307 (23%)
Query: 843 TWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPE 902
+W+ +PW+ CSA+C G + +EV C + N C KPP + +AC + CP
Sbjct: 1420 SWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTN-CSQVQKPPTH-KACRSVRCP-S 1476
Query: 903 WFIGDWLECSKTCDGGMRTRAVLC-IRKIGPSEEETLDYS------------GCLTHRPV 949
W W ECS TC G++ R V C ++ +G EE D S C+ H+ +
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGM 1536
Query: 950 EK------------------------------------------EPCNNQSCPPQWVALD 967
E+ + C N C V D
Sbjct: 1537 ERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTAD 1596
Query: 968 WSECTPKCGPGFKHRIVLC------KSSDLSKTFPAA--QCPEESKPPVRIRCSLGRCPP 1019
S+C CG ++ RI C K L + P +CP V +C
Sbjct: 1597 SSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQV-YQCINSCLHL 1655
Query: 1020 PRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISN 1079
W G W +CS CG+G R V+C++ G +S CL ++P + + KC + +
Sbjct: 1656 ATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGA----QKKCYANDCKS 1711
Query: 1080 TEECKDV 1086
CK++
Sbjct: 1712 FTTCKEI 1718
Score = 105 bits (261), Expect = 3e-22
Identities = 67/261 (25%), Positives = 110/261 (42%), Gaps = 19/261 (7%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPE- 902
WN+ W ECS TC GG++ + V+C + + I++++ C+ +KPP + C+ CP +
Sbjct: 1362 WNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVNKPP-SVIQCHMHACPADV 1419
Query: 903 -WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPP 961
W W CS +C G + R V CI + E+T + +P + C + C P
Sbjct: 1420 SWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT---NCSQVQKPPTHKACRSVRC-P 1475
Query: 962 QWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPR 1021
W A W+EC+ CG G + R V C+ + + C + ++P + RC C +
Sbjct: 1476 SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVV-EEMCDQSTRPCSQRRCWSQDCVQHK 1534
Query: 1022 WVTGDWGQCSAQCG----------LGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESK 1071
+ CS C Q+R V + Y S + R P
Sbjct: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT 1594
Query: 1072 CDSTPISNTEECKDVNKVAYC 1092
DS+ +N ++ YC
Sbjct: 1595 ADSSQCANNCGFSYRQRITYC 1615
Score = 38.1 bits (87), Expect = 0.047
Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 19/95 (20%)
Query: 494 YGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW 553
+G+ S C G R + C ++ + + A++ Q C G C
Sbjct: 1313 WGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQ-------CGPGPC------ 1359
Query: 554 PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSP 588
PQ W + WGECS+TCGGG+ S L C P
Sbjct: 1360 PQ-----WN-YGNWGECSQTCGGGIKSRLVICQFP 1388
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 590 bits (1521), Expect = e-168
Identities = 371/1079 (34%), Positives = 526/1079 (48%), Gaps = 93/1079 (8%)
Query: 84 KLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGP---------QWKHDFLDNCHYT 134
++ ++ A+ + +L L + F++ F VE GP Q C YT
Sbjct: 164 EVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYT 223
Query: 135 GYLQDQRSTTKVALSNCVG-LHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKK 193
G + + + + S C G L G I ++ FIEPL +T + GHPH +Y++
Sbjct: 224 GAVL-RHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAIT-------GHPHRVYRQ 275
Query: 194 SALQQRHLYD----HSH-CGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSI 248
+ + + HSH CG+ + G+P S I + R +
Sbjct: 276 KRSMEEKVTEKSALHSHYCGI--ISDKGRP----------RSRKIAESGRGKRYSYKLPQ 323
Query: 249 ERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTED 308
E +ET+VVAD MV YHG +IL+++N+V L++ SL VN+ V +LI+L E
Sbjct: 324 EYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHET 383
Query: 309 QPNLEINHHADKSLDSFCKWQKSILSHQSD----GNTIPENGIAHHDNAVLITRYDICTY 364
P L I HH +K L+SFCKWQ ++D +T + D A+LITR D C +
Sbjct: 384 PPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVH 443
Query: 365 KNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKG 424
K++PC T+G+A ++GMC +R C I ED GL AFTIAHE+GHN G+NHD SC
Sbjct: 444 KDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGL 503
Query: 425 HEAAKLMAAHIT--ANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPK--RDFLYPAVAP 480
H +M+ N SWS CS++ + FL S CL P+ + P+ P
Sbjct: 504 H----IMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLP 559
Query: 481 GQVYDADEQCRFQYGATSRQCKYGE--VCRELWC-LSKSNRCVTNSIPAAEGTLCQTGNI 537
G Y ADEQC+ +G + C+ + +C LWC + C T P +GT C G
Sbjct: 560 GMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGK- 618
Query: 538 EKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
WC G+C + P+ + G WSLW CSRTC G+SS R C P + C
Sbjct: 619 ---WCKAGECTSRTSAPEHLA---GEWSLWSPCSRTCSAGISSRERKC--PGLDSEARDC 670
Query: 598 LGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAE 657
G RK+YR C PCP G FR+ QC + K+ KPCAL C
Sbjct: 671 NGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPV 730
Query: 658 GYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCD 717
G + V+DGT C LDIC NG C+ VGCD +LGS ARED C VC G+G +C
Sbjct: 731 GKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCK 790
Query: 718 AIEGFFNDSLPRG-GYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDW 776
I+G FN + RG GY+EV+ IP G+ I+V E + +Y+AL+ G IN W I+
Sbjct: 791 IIKGDFNHT--RGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQ-SINSDWKIEH 847
Query: 777 PRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLL-QEQNLGIRYKFNVPI----T 831
F++AGT HY R E + A GPT+ L ++VLL Q+QN G+ Y++ +P
Sbjct: 848 SGAFNLAGTTVHYVR-RGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPE 906
Query: 832 RTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRL--DDNSIVQNNYCDPDSKPPE 889
S E F W H W +C ATC GG ++ V C ++ + SIV N C +KP
Sbjct: 907 NQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEP 966
Query: 890 NQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPV 949
R CN +PC W + +W CS+TC GM++R V C +++ C+ +P
Sbjct: 967 QIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPA 1026
Query: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVR 1009
+ C Q C W A WSEC+ KCG G +HR V C T P +C ++P
Sbjct: 1027 SAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC-------TNPRKKCVLSTRPREA 1079
Query: 1010 IRC-SLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCL-SYTGQASSDCLET-----VRP 1062
C +C W GDW +CS CG G Q R +QC+ TG+ ++C + RP
Sbjct: 1080 EDCEDYSKCYV--WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRP 1137
Query: 1063 PSMQQCESKCDSTPISN------TEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 1115
+Q C K + I++ T +C YC ++ + C + Q CC+TC+
Sbjct: 1138 CHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCR 1196
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 573 bits (1477), Expect = e-163
Identities = 367/1090 (33%), Positives = 510/1090 (46%), Gaps = 112/1090 (10%)
Query: 68 RRRRSMDPIDPQQAVSK--LFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKH 125
RRR P P+ + L L A+G+ +L L + F+S+ F VE G + +
Sbjct: 62 RRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRP 121
Query: 126 DFLDNCHYTGYLQDQRSTTKVALSNCV---GLHGVIATEDEEYFIEPLKNTTEDSKHFSY 182
L C Y+G + + V+LS C GL G+I E+ I+PL N+
Sbjct: 122 AEL--CFYSGRVLGHPGSL-VSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPF----- 173
Query: 183 ENGHPHVIYKKSALQQRHLYDHSH----CGVSDFTRSGKPWWLNDTSTVSYSLPINNTHI 238
+G H+I +K +L + C V T KP W P +
Sbjct: 174 -SGREHLIRRKWSLTPSPSAEAQRPEQLCKV--LTEKKKPTW---------GRPSRDWRE 221
Query: 239 HHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNII 298
R S E VETLVVAD MV YHG + + +IL+VMN+V +++ SLG +NI
Sbjct: 222 RRNAIRLTS-EHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQ 280
Query: 299 VARLIVLTEDQPNLEINHHADKSLDSFCKWQKSIL--SHQSDGNTIP--ENGIAHHDNAV 354
V +L++L + L I HH ++SL+SFC WQ + N +P ++ D AV
Sbjct: 281 VTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAV 340
Query: 355 LITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHD 414
+TR D C +K++PC T+G+A + G+C +R C + ED GL AFTIAHE+GHN GMNHD
Sbjct: 341 FVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHD 400
Query: 415 GIGNSCGTKGHEAAKLMAAHITANTNP--FSWSACSRDYITSFLDSGRGTCLDNEPPKRD 472
+SC + H +M+ NP SWS+CSRD + +FL S TCL P+
Sbjct: 401 DDHSSCAGRSH----IMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQ 456
Query: 473 FLY--PAVAPGQVYDADEQCRFQYGATSRQCKYGE--VCRELWCLSKSNR-CVTNSIPAA 527
P PG Y A+EQC+ +G + C+ E +C LWCL + + C T P
Sbjct: 457 HTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPL 516
Query: 528 EGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDS 587
+GT C WC G+CV P+ +DG W PW W CSRTCG G R CD+
Sbjct: 517 DGTECGADK----WCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDN 572
Query: 588 PAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGV 647
P P GG +C G + C PCP G FR++QC D + + K
Sbjct: 573 PPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLTAVVVDD-- 630
Query: 648 KPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCR 707
KPC L C G A V+DGT C D+C++G+C+ +GCD I+GS A+EDRC
Sbjct: 631 KPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCG 690
Query: 708 VCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYY 767
VC GDG TC ++G F+ + RG+ ALK G
Sbjct: 691 VCSGDGKTCHLVKGDFSHA-------------RGT---------------ALKDSGKG-S 721
Query: 768 INGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLL-QEQNLGIRYKF 826
IN W I+ P +F +AGT Y R E + A GPT L +MVLL +Q+ GI Y++
Sbjct: 722 INSDWKIELPGEFQIAGTTVRYVR-RGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY 780
Query: 827 NVPITRTGSGDNEVG------FTWNHQPWSECSATCAGGVQRQEVVCKRL--DDNSIVQN 878
VP+ RT +E F W H W CS C GG +R V C R+ ++V +
Sbjct: 781 TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND 840
Query: 879 NYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETL 938
+ C S+P R CN PC W G W CS TC+ G + R V C+ ++
Sbjct: 841 SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT 900
Query: 939 DYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAA 998
C RP + C Q C W A +WS+C+ CG G R V C +S
Sbjct: 901 RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQ-------G 953
Query: 999 QCPEESKPPVRIRC-SLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCL-SYTGQASSDC 1056
+C ++P C C W TGDW CS+ CG G Q R VQC+ TG+ S+C
Sbjct: 954 KCDASTRPRAEEACEDYSGC--YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSEC 1011
Query: 1057 LETVRPPSMQQC-ESKCDSTPISN----------TEECKDVNKVAYCPLVLKFKFCSRAY 1105
+P +QC + C+ +N T +C YC ++ + C
Sbjct: 1012 PALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMR 1071
Query: 1106 FRQMCCKTCQ 1115
+ Q CC+TC+
Sbjct: 1072 WYQRCCQTCR 1081
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 550 bits (1417), Expect = e-156
Identities = 344/1022 (33%), Positives = 508/1022 (49%), Gaps = 94/1022 (9%)
Query: 42 YQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLT 101
Y+L P+ + G +LS T+ R R + +P+Q LFF ++A+GK FHL L
Sbjct: 42 YELVTPVSTNLEGRYLSHTLSASHKKRSARDVSS-NPEQ----LFFNITAFGKDFHLRLK 96
Query: 102 LNTDFVSKHFTVEYWGKD-------GPQWKHD-------------FLDNCHYTGYLQDQR 141
NT V+ VE+ P H NC Y G + D
Sbjct: 97 PNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIP 156
Query: 142 STTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHL 201
T+ VA+SNC GL G+I +++EEYFIEPL E K E G HV+YK+SA++Q +
Sbjct: 157 GTS-VAISNCDGLAGMIKSDNEEYFIEPL----ERGKQMEEEKGRIHVVYKRSAVEQAPI 211
Query: 202 YDHSHCGVSDF-TRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADK 260
D S DF R L+D TV ++ R++ + + +E L+ D
Sbjct: 212 -DMS----KDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDD 266
Query: 261 MMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQP-NLEINHHAD 319
+V +HG++ +++Y+L++MNIV ++Y D SLG +N+++ R+I+L + +L +
Sbjct: 267 SVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPS 326
Query: 320 KSLDSFCKW----QKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLA 375
+SL++ C+W Q+S L+H HHD+A+ +TR D P G G A
Sbjct: 327 RSLENVCRWASQQQRSDLNHSE-----------HHDHAIFLTRQDF-----GPAGMQGYA 370
Query: 376 SVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHI 435
V GMC P RSC++N + G SAF +AHE GH GM HDG GN CG + +MA +
Sbjct: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE-TAMGSVMAPLV 429
Query: 436 TANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYG 495
A + + WS CS + ++ S CL ++P D+ PG Y DEQCRF +G
Sbjct: 430 QAAFHRYHWSRCSGQELKRYIHS--YDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFG 487
Query: 496 ATSRQC---KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPF 550
+ C + + C++LWC N C T P +GT C G WCY+G C+
Sbjct: 488 VGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGK----WCYKGHCMWK 543
Query: 551 GTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTD 610
Q DG WG W+ +G CSRTCG GV R C++P P GG+ C G Y+ CNT+
Sbjct: 544 NANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTE 603
Query: 611 PCPLGSRDFREKQCADFD-NMPFRGKYYNWKPYTGGGVKP-CALNCLAEGYNFYTERAPA 668
C DFR +QC + + ++ ++W PY K C L C ++
Sbjct: 604 ECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQL 663
Query: 669 VIDGTQCN-ADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSL 727
V DGT C+ D IC+ GEC VGCD +GS+ ED+C VCGGD S C ++G F +
Sbjct: 664 VHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTP 723
Query: 728 PRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYI-NGAWTIDWPRKFDVAGTA 786
+ GY+++ IP G+ H+ ++E S + +A+K++ +YI NG R F G
Sbjct: 724 RKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVE 783
Query: 787 FHYKRPTDEPESLEALGPTSENLIVMVLLQEQNL--GIRYKF-----NVPITRTGSGDNE 839
+ Y D+ ESL GP + +IV+++ QE + + YK+ +VP + + E
Sbjct: 784 WDY-NIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQE 842
Query: 840 V--GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTE 897
F W + WS+CS C GG Q + C+R DN +V ++C+ + KP +R CN +
Sbjct: 843 ELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQ 902
Query: 898 PCP-PEWFIGDWLECSKTC-DGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCN 955
C P W +W C+KTC G + R V C++ + ++ C+ RP + PCN
Sbjct: 903 ECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCN 962
Query: 956 NQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLG 1015
CP QW WSEC+ CG G + R VLC++ D C E VR C L
Sbjct: 963 RVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGD--------HCDGEKPESVR-ACQLP 1013
Query: 1016 RC 1017
C
Sbjct: 1014 PC 1015
Score = 51.6 bits (122), Expect = 4e-06
Identities = 25/64 (39%), Positives = 34/64 (53%), Gaps = 10/64 (15%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
W PWSECS TC G + ++V+C+ D +CD + PE+ RAC PC E
Sbjct: 970 WKTGPWSECSVTCGEGTEVRQVLCRAGD--------HCDGEK--PESVRACQLPPCNDEP 1019
Query: 904 FIGD 907
+GD
Sbjct: 1020 CLGD 1023
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 541 bits (1394), Expect = e-153
Identities = 344/1110 (30%), Positives = 545/1110 (49%), Gaps = 113/1110 (10%)
Query: 44 LTIPIRVDQNGAFLSFTVK--NDKHSRRRRSMDPI--------DPQQAVSKLFFKLSAYG 93
L +P+R D G +S V + R R P+ + ++ S LF+ ++ +G
Sbjct: 58 LAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFG 117
Query: 94 KHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVG 153
+ HL L N V+ T+E+ G+ G L +C Y G + + VALSNC G
Sbjct: 118 RDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDG 177
Query: 154 LHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFT 213
L G+I E+EE+FIEPL+ + E G HV+Y++ G
Sbjct: 178 LAGLIRMEEEEFFIEPLEKGLAAQEA---EQGRVHVVYRRPPTSPP-------LGGPQAL 227
Query: 214 RSGKPWWLNDTSTVSYSLPINNTHIHHRQKRS----VSIERFVETLVVADKMMVGYHGRK 269
+G L+ ++S +L + H + ++R+ + +E L+ D +V +HG++
Sbjct: 228 DTGAS--LDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKE 285
Query: 270 DIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLT--EDQPNLEINHHADKSLDSFCK 327
++ Y+L++MNIV ++Y D SLG +N+++ R+I+L+ + +EI + + +SL++ C+
Sbjct: 286 HVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPS-QSLENVCR 344
Query: 328 W----QKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEP 383
W QK H +HD+A+ +TR D P G G A V GMC P
Sbjct: 345 WAYLQQKPDTGHDE-----------YHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHP 388
Query: 384 ERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFS 443
RSC++N + G SAF +AHE GH GM HDG GN CG + +MA + A + F
Sbjct: 389 VRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVR-LGSIMAPLVQAAFHRFH 447
Query: 444 WSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQC-- 501
WS CS+ ++ +L S CL ++P D+ PG Y +EQCRF +G C
Sbjct: 448 WSRCSQQELSRYLHSY--DCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTA 505
Query: 502 -KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSID 558
+ + C++LWC N C T P +GT+C G C++G C+ D
Sbjct: 506 FRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGK----HCFKGHCIWLTPDILKRD 561
Query: 559 GGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRD 618
G WG WS +G CSRTCG GV R CD+P P+ GG+ C G ++ C+ CP D
Sbjct: 562 GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLAD 621
Query: 619 FREKQCADFDNMPFRGK-YYNWKPYTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCN 676
FRE+QC +D G ++W P+ K C L C + V DGT+C+
Sbjct: 622 FREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCS 681
Query: 677 -ADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEV 735
D+ +C+ G+C+ VGCD ++GS +ED+C VCGGD S C ++G F S + GY+++
Sbjct: 682 YKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKM 741
Query: 736 VQIPRGSVHIEVREVAMSKNYIALKS-EGDDYYINGAWTIDWPRK-FDVAGTAFHYKRPT 793
+IP G+ H+ ++EV + +++A+K+ E + +N +D K F G + Y R
Sbjct: 742 FEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEY-RDE 800
Query: 794 DEPESLEALGPTSENLIVMVL-LQEQNLGIRYKFNVPITRTGSGDN------EVGFTWNH 846
D E+L+ +GP + V+V+ + + + + YK+ + DN V + W
Sbjct: 801 DGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWAL 860
Query: 847 QPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC-PPEWFI 905
+ WS CS C GG Q + C+R D+ +V +C SKP +RACN + C P W
Sbjct: 861 KKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVT 920
Query: 906 GDWLECSKTCD-GGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWV 964
G+W CS+TC GM+ R+V CI+ + + ++ C RP + C+ + CP +W
Sbjct: 921 GEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWR 980
Query: 965 ALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVT 1024
A WS+C+ CG G + R VLC+++D +F Q E +P C LG C PR ++
Sbjct: 981 AGPWSQCSVTCGNGTQERPVLCRTAD--DSFGICQ---EERPETARTCRLGPC--PRNIS 1033
Query: 1025 GDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECK 1084
++ VQ LS RP + IS+ C+
Sbjct: 1034 DP----------SKKSYVVQWLS-------------RP------DPDSPIRKISSKGHCQ 1064
Query: 1085 DVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
+K +C + + ++CS + ++CCK+C
Sbjct: 1065 G-DKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 517 bits (1332), Expect = e-146
Identities = 348/1134 (30%), Positives = 525/1134 (46%), Gaps = 130/1134 (11%)
Query: 39 LEHYQLTIPIRVDQNGAFLSFTVKND-----------------KHSRRRR-SMDPIDPQQ 80
L Y +T+P D G FLS V +HS R + P+ P
Sbjct: 35 LSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGG 94
Query: 81 AV-------SKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHY 133
+ L+F ++ +GK HL L N V +VE+ ++ C Y
Sbjct: 95 TLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVY 154
Query: 134 TGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKK 193
TG + VA+SNC GL G+I T+ ++FIEPL+ ++ + +G HV+Y++
Sbjct: 155 TGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLERGQQEKE----ASGRTHVVYRR 209
Query: 194 SALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVE 253
A+QQ F P N V L H + S SIE
Sbjct: 210 EAVQQEWAEPDGDLHNEAFGLGDLP---NLLGLVGDQLGDTERKRRHAKPGSYSIE---- 262
Query: 254 TLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQP-NL 312
L+V D +V +HG++ +++Y+L++MNIV ++Y D SLG +NI + RLI++ Q +L
Sbjct: 263 VLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSL 322
Query: 313 EINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTL 372
+ +SL+ C+W S Q + E HHD+ V +TR D P G
Sbjct: 323 IERGNPSRSLEQVCRWAHS---QQRQDPSHAE----HHDHVVFLTRQDF-----GPSGMQ 370
Query: 373 GLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMA 432
G A V GMC P RSC++N + G SAF IAHE GH GM HDG GN C + +MA
Sbjct: 371 GYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADET-SLGSVMA 429
Query: 433 AHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRF 492
+ A + F WS CS+ ++ +L S CL ++P + P PG Y DEQCRF
Sbjct: 430 PLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRF 487
Query: 493 QYGATSRQC---KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDC 547
+G+ + C + E C++LWC N C T P +GT C G WC++G C
Sbjct: 488 DFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGK----WCFKGHC 543
Query: 548 V---PFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRY 604
+ P T+ Q DGGW W+ +G CSR+CGGGV S R C++P+P+ GG+ CLG Y
Sbjct: 544 IWKSPEQTYGQ--DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEY 601
Query: 605 RSCNTDPCPLGSRDFREKQCADFDNMPFRGKYY-------NWKPY-TGGGVKPCALNCLA 656
+ CN++ CP DFR +QCA R YY +W PY + C L C +
Sbjct: 602 QVCNSEECPGTYEDFRAQQCAK------RNSYYVHQNAKHSWVPYEPDDDAQKCELICQS 655
Query: 657 EGYNFYTERAPAVIDGTQCN-ADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGST 715
V DGT+C+ D +C GEC VGCD +GS +D+C VCGGD S
Sbjct: 656 ADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSH 715
Query: 716 CDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSE-GDDYYINGAWTI 774
C ++G + + G +++VQIP G+ HI++ + S + I +K++ + +N
Sbjct: 716 CRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKE 775
Query: 775 DWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQ-----NLGIRYKFNVP 829
R F G + D ESL+ GP E + ++ L + +L +Y +
Sbjct: 776 ATSRTFTAMGLEWE-DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHED 834
Query: 830 ITRTGSGDNEV-----GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPD 884
+ +N + + W + W+ CS C GG+Q + C+R D+ +VQ + CD
Sbjct: 835 LLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHK 894
Query: 885 SKPPENQRACNTEPC-PPEWFIGDWLECSKTCDG-GMRTRAVLCIRKIGPSEEETLDYSG 942
+P +R CN PC P W +W CS++C G++TR + C+ + + +
Sbjct: 895 KRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKA 954
Query: 943 CLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPE 1002
C RP + PC CP QW WS+C+ CG G + R V+C+++ S C
Sbjct: 955 CAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANS----LGHCEG 1010
Query: 1003 ESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRP 1062
+ V++ CSL CG Q TV+ +D E P
Sbjct: 1011 DRPDTVQV-CSL-----------------PACGGNHQNSTVR---------ADVWELGTP 1043
Query: 1063 PS--MQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
+ Q E IS+TE C ++ +C + + ++CS + ++CC +C
Sbjct: 1044 EGQWVPQSEPLHPINKISSTEPCTG-DRSVFCQMEVLDRYCSIPGYHRLCCVSC 1096
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 514 bits (1325), Expect = e-145
Identities = 347/1134 (30%), Positives = 524/1134 (46%), Gaps = 133/1134 (11%)
Query: 39 LEHYQLTIPIRVDQNGAFLSFTVKND-----------------KHSRRRR-SMDPIDPQQ 80
L Y +T+P D G FLS V +HS R + P+ P
Sbjct: 35 LSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGG 94
Query: 81 AV-------SKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHY 133
+ L+F ++ +GK HL L N V +VE+ ++ C Y
Sbjct: 95 TLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVY 154
Query: 134 TGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKK 193
TG + VA+SNC GL G+I T+ ++FIEPL+ ++ + +G HV+Y++
Sbjct: 155 TGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLERGQQEKE----ASGRTHVVYRR 209
Query: 194 SALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVE 253
A+QQ F P N V L H + S SIE
Sbjct: 210 EAVQQEWAEPDGDLHNEAFGLGDLP---NLLGLVGDQLGDTERKRRHAKPGSYSIE---- 262
Query: 254 TLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQP-NL 312
L+V D +V +HG++ +++Y+L++MNIV ++Y D SLG +NI + RLI++ Q +L
Sbjct: 263 VLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSL 322
Query: 313 EINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTL 372
+ +SL+ C+W S Q + E HHD+ V +TR D G
Sbjct: 323 IERGNPSRSLEQVCRWAHS---QQRQDPSHAE----HHDHVVFLTRQDF--------GPS 367
Query: 373 GLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMA 432
G A V GMC P RSC++N + G SAF IAHE GH GM HDG GN C + +MA
Sbjct: 368 GYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADET-SLGSVMA 426
Query: 433 AHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRF 492
+ A + F WS CS+ ++ +L S CL ++P + P PG Y DEQCRF
Sbjct: 427 PLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRF 484
Query: 493 QYGATSRQC---KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDC 547
+G+ + C + E C++LWC N C T P +GT C G WC++G C
Sbjct: 485 DFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGK----WCFKGHC 540
Query: 548 V---PFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRY 604
+ P T+ Q DGGW W+ +G CSR+CGGGV S R C++P+P+ GG+ CLG Y
Sbjct: 541 IWKSPEQTYGQ--DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEY 598
Query: 605 RSCNTDPCPLGSRDFREKQCADFDNMPFRGKYY-------NWKPY-TGGGVKPCALNCLA 656
+ CN++ CP DFR +QCA R YY +W PY + C L C +
Sbjct: 599 QVCNSEECPGTYEDFRAQQCAK------RNSYYVHQNAKHSWVPYEPDDDAQKCELICQS 652
Query: 657 EGYNFYTERAPAVIDGTQCN-ADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGST 715
V DGT+C+ D +C GEC VGCD +GS +D+C VCGGD S
Sbjct: 653 ADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSH 712
Query: 716 CDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSE-GDDYYINGAWTI 774
C ++G + + G +++VQIP G+ HI++ + S + I +K++ + +N
Sbjct: 713 CRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKE 772
Query: 775 DWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQ-----NLGIRYKFNVP 829
R F G + D ESL+ GP E + ++ L + +L +Y +
Sbjct: 773 ATSRTFTAMGLEWE-DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHED 831
Query: 830 ITRTGSGDNEV-----GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPD 884
+ +N + + W + W+ CS C GG+Q + C+R D+ +VQ + CD
Sbjct: 832 LLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHK 891
Query: 885 SKPPENQRACNTEPC-PPEWFIGDWLECSKTCDG-GMRTRAVLCIRKIGPSEEETLDYSG 942
+P +R CN PC P W +W CS++C G++TR + C+ + + +
Sbjct: 892 KRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKA 951
Query: 943 CLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPE 1002
C RP + PC CP QW WS+C+ CG G + R V+C+++ S C
Sbjct: 952 CAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANS----LGHCEG 1007
Query: 1003 ESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRP 1062
+ V++ CSL CG Q TV+ +D E P
Sbjct: 1008 DRPDTVQV-CSL-----------------PACGGNHQNSTVR---------ADVWELGTP 1040
Query: 1063 PS--MQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
+ Q E IS+TE C ++ +C + + ++CS + ++CC +C
Sbjct: 1041 EGQWVPQSEPLHPINKISSTEPCTG-DRSVFCQMEVLDRYCSIPGYHRLCCVSC 1093
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 486 bits (1251), Expect = e-137
Identities = 300/890 (33%), Positives = 443/890 (49%), Gaps = 72/890 (8%)
Query: 88 KLSAYGKHFHLNLTLNTDFVSKHFTVEYWGK----DGPQWKHDFLDNCHYTGYLQDQRST 143
+L A+ + L L ++ F++ FT++ G+ + P + D L +C Y+G + S+
Sbjct: 77 RLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETD-LAHCFYSGTVNGDPSS 135
Query: 144 TKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYD 203
ALS C G+ G E YFI+PL +E + P + + R
Sbjct: 136 A-AALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDV 194
Query: 204 HSHCGVSDFTR-------------------SGKPWWLNDTSTVSYSLPINNTHIHHRQKR 244
CGV D G W D + P I R+KR
Sbjct: 195 GGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSI--RKKR 252
Query: 245 SVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIV 304
VS R+VET++VAD+ M +HG ++HY+L++ ++ A+LY+ S+ N V+++V +++V
Sbjct: 253 FVSSHRYVETMLVADQSMAEFHG-SGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILV 311
Query: 305 LTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTY 364
+ ++Q E+ +A +L +FC WQK N + H+D A+L TR D+C
Sbjct: 312 IHDEQKGPEVTSNAALTLRNFCNWQKQ-------HNPPSDRDAEHYDTAILFTRQDLCG- 363
Query: 365 KNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKG 424
++ C TLG+A V +C+P RSCS+ ED GL +AFT AHE+GH F M HD G
Sbjct: 364 -SQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNG 422
Query: 425 -HEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQV 483
++ + +MA+ ++ + WS CS ITSFLD+G G CL ++P + P PG
Sbjct: 423 VNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP-QNPIQLPGDLPGTS 481
Query: 484 YDADEQCRFQYGATSRQCK-YGEVCRELWCLSKSNR---CVTNSIPAAEGTLCQTGNIEK 539
YDA+ QC+F +G S+ C C LWC S C T P A+GT C G
Sbjct: 482 YDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGK--- 538
Query: 540 GWCYQGDCVPFGT---WPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKY 596
WC G CV + G WG W WG+CSRTCGGGV ++R CD+P P GGKY
Sbjct: 539 -WCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKY 597
Query: 597 CLGERKRYRSCNTDPCP-LGSRDFREKQCA---DFDNMPF-RGKYYNWKP-YTGGGVKP- 649
C G+R RYRSCN + CP + FRE+QC +F F G W P Y G K
Sbjct: 598 CEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDR 657
Query: 650 CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVC 709
C L C A+G ++ P V+DGT C+ DS +C+ G+C GCD I+ S + D+C VC
Sbjct: 658 CKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVC 717
Query: 710 GGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEV--REVAMSKN---YIALKSEGD 764
GG+GSTC I G + P GY +++ IP G+ +IEV R S+N ++A+K+
Sbjct: 718 GGNGSTCKKISGSVTSAKP--GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADG 775
Query: 765 DYYINGAWTID-WPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIR 823
Y +NG +T+ + G Y + E + + P E L + VL L +
Sbjct: 776 TYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPK 835
Query: 824 YKFNVPITRTGSGDNEVG--FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYC 881
K+ + + N + W + W ECS +C G QR+ V C+ ++ + C
Sbjct: 836 IKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE---C 892
Query: 882 DPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIG 931
+ K P + R C PC P+W +G+W CSKTC G + R++ C+ G
Sbjct: 893 AKEVK-PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKCLSHDG 940
Score = 71.6 bits (174), Expect = 4e-12
Identities = 35/101 (34%), Positives = 54/101 (53%), Gaps = 5/101 (4%)
Query: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVR 1009
+KE N WV +W EC+ C G++ R+V C+ + PA++C +E KP
Sbjct: 845 KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ---PASECAKEVKPAST 901
Query: 1010 IRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTG 1050
C+ CP +W G+W CS CG G + R+++CLS+ G
Sbjct: 902 RPCADHPCP--QWQLGEWSSCSKTCGKGYKKRSLKCLSHDG 940
Score = 55.1 bits (131), Expect = 4e-07
Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 1022 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQC-ESKCDSTPISNT 1080
WV +WG+CS C LG Q R V+C GQ +S+C + V+P S + C + C +
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEW 917
Query: 1081 EEC 1083
C
Sbjct: 918 SSC 920
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 15 preproprotein [Homo
sapiens]
Length = 950
Score = 481 bits (1239), Expect = e-135
Identities = 336/1008 (33%), Positives = 471/1008 (46%), Gaps = 114/1008 (11%)
Query: 43 QLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTL 102
++ +PIR+D D + RR P D L F+++A+ + F+L+LT
Sbjct: 24 EVVVPIRLDP-----------DINGRRYYWRGPEDSGD--QGLIFQITAFQEDFYLHLTP 70
Query: 103 NTDFVSKHFTVEYWGK--DGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIAT 160
+ F++ F+ E+ G G L C Y+G + + + A+S C GL G
Sbjct: 71 DAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSF-AAVSLCGGLRGAFGY 129
Query: 161 EDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWW 220
EY I PL N + + + + H ++ ++ S CGV+
Sbjct: 130 RGAEYVISPLPNASAPAAQRNSQGAH--LLQRRGVPGGPSGDPTSRCGVASGWNPAILRA 187
Query: 221 LNDTSTVSYSLPINNTHIHH-RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVM 279
L+ + + R KR VSI R+VETLVVAD+ MV +HG D+EHY+L+++
Sbjct: 188 LDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGA-DLEHYLLTLL 246
Query: 280 NIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDG 339
A+LYR S+ N +NI+V ++++L + ++ +A +L +FC WQK +
Sbjct: 247 ATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKL------- 299
Query: 340 NTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAF 399
N + + + D A+L TR D+C C TLG+A V MC+P+RSCS+ ED GL SAF
Sbjct: 300 NKVSDKHPEYWDTAILFTRQDLCGATT--CDTLGMADVGTMCDPKRSCSVIEDDGLPSAF 357
Query: 400 TIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANT-------NPFSWSACSRDYI 452
T AHE+GH F M HD + G KL A H+ + T NP WSACS I
Sbjct: 358 TTAHELGHVFNMPHDNVKVCEEVFG----KLRANHMMSPTLIQIDRANP--WSACSAAII 411
Query: 453 TSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWC 512
T FLDSG G CL ++P K L P PG Y +QC +G S+ C Y + C +LWC
Sbjct: 412 TDFLDSGHGDCLLDQPSKPISL-PEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWC 470
Query: 513 LSKSNR---CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVP-FGTWPQSIDGGWGPWSLWG 568
K+ C T P A+GT C G + C +G CV +DG W W +G
Sbjct: 471 TGKAKGQMVCQTRHFPWADGTSCGEGKL----CLKGACVERHNLNKHRVDGSWAKWDPYG 526
Query: 569 ECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGS--RDFREKQCAD 626
CSRTCGGGV + R C +P P+ GGKYC G R +YRSCN +PCP + + FRE+QC
Sbjct: 527 PCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEA 586
Query: 627 FDNMPFRGKYYN----WKPYTGGGVKP---CALNCLAEGYNFYTERAPAVIDGTQCNADS 679
F+ W P G V P C L C A G ++ AP V+DGT C+ DS
Sbjct: 587 FNGYNHSTNRLTLAVAWVPKYSG-VSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDS 645
Query: 680 LDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIP 739
+C+ G+C GCD LGS R D+C VCGGD +C + G F P GY VV IP
Sbjct: 646 TSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTK--PMHGYNFVVAIP 703
Query: 740 RGSVHIEVRE-----VAMSKNYIALKSEGDDYYINGAWTIDW-PRKFDVAGTAFHYKRPT 793
G+ I++R+ + NY+ALK+ Y +NG + + R V G+ Y
Sbjct: 704 AGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTG 763
Query: 794 DEPESLEALGPTSENLIVMVLLQEQNLG--IRYKFNVPITRTGSGDNEVGFTWNHQPWSE 851
ESL+A P E L V VL + +RY F +P +P +
Sbjct: 764 TAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLP----------------KEPRED 807
Query: 852 CSATCAGGVQRQEVVCKRLDDNSIVQ--NNYCDPDSKPPENQRACNTEPCPPEWFIGDWL 909
S+ ++ + NS++ N PD +PP W G W
Sbjct: 808 KSS------HPKDPRGPSVLHNSVLSLSNQVEQPDDRPPAR------------WVAGSWG 849
Query: 910 ECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWS 969
CS +C G++ RAV C G D HRPVE + C + C P W WS
Sbjct: 850 PCSASCGSGLQKRAVDCRGSAGQRTVPACD----AAHRPVETQAC-GEPC-PTWELSAWS 903
Query: 970 ECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 1017
C+ CG GF+ R + C + QC KP C L C
Sbjct: 904 PCSKSCGRGFQRRSLKCVGHG-GRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 67.0 bits (162), Expect = 9e-11
Identities = 36/111 (32%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 960 PPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPP 1019
P +WVA W C+ CG G + R V C+ S +T PA C +P C P
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA--CDAAHRPVETQACGE---PC 894
Query: 1020 PRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQ--ASSDCLETVRPPSMQQC 1068
P W W CS CG G Q R+++C+ + G+ A C +P + C
Sbjct: 895 PTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
Score = 59.3 bits (142), Expect = 2e-08
Identities = 35/101 (34%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 1018 PPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS-SDCLETVRPPSMQQCESKCDSTP 1076
PP RWV G WG CSA CG G Q R V C GQ + C RP Q C C +
Sbjct: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWE 898
Query: 1077 ISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH 1117
+S C K C R + R+ C GH
Sbjct: 899 LSAWSPCS--------------KSCGRGFQRRSL--KCVGH 923
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 452 bits (1162), Expect = e-126
Identities = 298/871 (34%), Positives = 429/871 (49%), Gaps = 81/871 (9%)
Query: 84 KLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRST 143
K+ + + A G+ F L+L + F G P W+H +C Y G + D
Sbjct: 86 KVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGTSAP-WRHR--SHCFYRGTV-DGSPR 141
Query: 144 TKVALSNCVGLHGVIATEDEEYFIEPLKNT--TEDSKHFSYENGHPHVI-------YKKS 194
+ C GL G A + Y ++PL E+ K Y +G ++ +
Sbjct: 142 SLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFE 201
Query: 195 ALQQR----------HLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKR 244
AL R ++H+ + R+ L D S +S + R++R
Sbjct: 202 ALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRR 261
Query: 245 SVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIV 304
S+S R VE L+VAD M +GR ++HY+L++ +I +LY +S+ N + + V +++V
Sbjct: 262 SISRARQVELLLVADASMARLYGR-GLQHYLLTLASIANRLYSHASIENHIRLAVVKVVV 320
Query: 305 LTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTY 364
L + +LE++ +A +L +FCKWQ HQ N + ++ H+D A+L TR D+C +
Sbjct: 321 LGDKDKSLEVSKNAATTLKNFCKWQ-----HQH--NQLGDDHEEHYDAAILFTREDLCGH 373
Query: 365 KNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKG 424
+ C TLG+A V +C PERSC++ ED GL +AFT+AHEIGH G++HD T G
Sbjct: 374 HS--CDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFG 431
Query: 425 H-EAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQV 483
E +LM++ +T+ WS C+ IT FLD G G CL + P++ L P PGQ
Sbjct: 432 STEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCL-LDLPRKQILGPEELPGQT 490
Query: 484 YDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNR---CVTNSIPAAEGTLCQTGNIEKG 540
YDA +QC +G C +VC LWC C+T +PA EGT C G I
Sbjct: 491 YDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRI--- 547
Query: 541 WCYQGDCVPFGT---WPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
C QG CV + S G WG W WG+CSR+CGGGV + RHC++PAP G+YC
Sbjct: 548 -CLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC 606
Query: 598 LGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGK----YYNWKPYTGGGVKP---C 650
G+R YRSC+ PCP + FR +QC + K + W P GV P C
Sbjct: 607 TGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVP-KYAGVLPADVC 665
Query: 651 ALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCG 710
L C A+G +Y +P V DGT+C S +C+ G+C GCD I+GS + D+C VCG
Sbjct: 666 KLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCG 725
Query: 711 GDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKN-----YIALKSEGDD 765
GD S+C I G FN GY +VV+IP G+ HI+VR+ Y+ALK + +
Sbjct: 726 GDNSSCTKIVGTFNKK--SKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGE 783
Query: 766 YYINGAWTIDWPRK-FDVAGTAFHYKRPTDEPESLEALG--PTSENLIVMVLLQE--QNL 820
Y ING + I D+ GT +Y + + L +G T E LIV +L + + L
Sbjct: 784 YLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPL 843
Query: 821 GIRYKFNVP-------ITRTGSGDNEVGF-----TWNHQPWSECSATCAGGVQRQEVVCK 868
+RY F VP + T G N+VG W PW CS TC G + V C+
Sbjct: 844 DVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQ 903
Query: 869 RLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
D N + P S+ P + C + C
Sbjct: 904 --DGNRKLAKGC--PLSQRPSAFKQCLLKKC 930
Score = 48.1 bits (113), Expect = 5e-05
Identities = 26/74 (35%), Positives = 34/74 (45%), Gaps = 6/74 (8%)
Query: 1001 PEESKPPVRIRCSLG------RCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASS 1054
P++S P V S G P+WVTG W CS C G RTVQC + +
Sbjct: 852 PKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAK 911
Query: 1055 DCLETVRPPSMQQC 1068
C + RP + +QC
Sbjct: 912 GCPLSQRPSAFKQC 925
Score = 37.0 bits (84), Expect = 0.10
Identities = 18/57 (31%), Positives = 25/57 (43%), Gaps = 3/57 (5%)
Query: 961 PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 1017
PQWV W C+ C G+ R V C+ + A CP +P +C L +C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKL---AKGCPLSQRPSAFKQCLLKKC 930
Score = 34.3 bits (77), Expect = 0.68
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 9/55 (16%)
Query: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNN--YCDPDSKPPENQRACNTEPCPP 901
W +CS +C GGVQ C +N +NN YC + R+C+ PCPP
Sbjct: 576 WGQCSRSCGGGVQFAYRHC----NNPAPRNNGRYC---TGKRAIYRSCSLMPCPP 623
Score = 32.0 bits (71), Expect = 3.4
Identities = 42/189 (22%), Positives = 75/189 (39%), Gaps = 31/189 (16%)
Query: 847 QPWSECSATCAGGVQRQEVVCKRLDDN------SIVQNNYCDPDSKPPENQRACNTEPCP 900
+PWS+C++ + + LDD + + P+ P + A T+ C
Sbjct: 450 KPWSKCTSA---------TITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDA--TQQCN 498
Query: 901 ----PEWFIGDWLE-CSKTCDGGMRTRAVLCIRKIGPSEEETLDYSG--CLTHRPVEK-- 951
PE+ + ++ C++ +R ++C+ K P+ E T G CL + V+K
Sbjct: 499 LTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTK 558
Query: 952 EPCNNQSCPPQWVAL-DWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRI 1010
+ + S W + W +C+ CG G + C + + C K +
Sbjct: 559 KKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNP--APRNNGRYC--TGKRAIYR 614
Query: 1011 RCSLGRCPP 1019
CSL CPP
Sbjct: 615 SCSLMPCPP 623
Score = 30.8 bits (68), Expect = 7.5
Identities = 19/71 (26%), Positives = 30/71 (42%), Gaps = 6/71 (8%)
Query: 906 GDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVA 965
G W +CS++C GG++ C P+ Y C R + + C+ CPP +
Sbjct: 574 GSWGQCSRSCGGGVQFAYRHC---NNPAPRNNGRY--CTGKRAIYRS-CSLMPCPPNGKS 627
Query: 966 LDWSECTPKCG 976
+C K G
Sbjct: 628 FRHEQCEAKNG 638
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 426 bits (1094), Expect = e-119
Identities = 280/773 (36%), Positives = 387/773 (50%), Gaps = 70/773 (9%)
Query: 81 AVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQ 140
A ++L +L A+G+ L L ++ + TV+Y G+ P+ + TG +
Sbjct: 77 APARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQ-APELLGGAEPGTYLTGTINGD 135
Query: 141 RSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHP--HVIYKKSALQQ 198
+ + L GV+ E ++PL+ T +S G P H++ +KS
Sbjct: 136 PESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSA------GGPGAHILRRKSPA-- 187
Query: 199 RHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVA 258
SG+ N + + P R KR S+ RFVETLVVA
Sbjct: 188 ----------------SGQGPMCNVKAPLGSPSPRPR-----RAKRFASLSRFVETLVVA 226
Query: 259 DKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHA 318
D M +HG ++ Y+L+VM AK ++ S+ N V+++V RL++L + ++ A
Sbjct: 227 DDKMAAFHGA-GLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSA 285
Query: 319 DKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVA 378
++L SFC WQ+ + NT ++ H D A+L TR D+C C TLG+A V
Sbjct: 286 AQTLRSFCAWQRGL-------NTPEDSDPDHFDTAILFTRQDLCGVST--CDTLGMADVG 336
Query: 379 GMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGH-EAAKLMAAHITA 437
+C+P RSC+I ED GL SAFT AHE+GH F M HD G ++ + A + A
Sbjct: 337 TVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMA 396
Query: 438 NTNPFS-WSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGA 496
+ +P WS CS +IT FLD+G G CL ++P L P PG+ YDAD QC+ +G
Sbjct: 397 HVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHL-PVTFPGKDYDADRQCQLTFGP 455
Query: 497 TSRQC-KYGEVCRELWCLSKSN---RCVTNSIPAAEGTLCQTGNIEKGW-CYQGDCVPFG 551
SR C + C LWC N C T P A+GT C G C D +
Sbjct: 456 DSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDF 515
Query: 552 TWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDP 611
PQ+ GGWGPW WG+CSRTCGGGV S R C P P GGKYC G R R+RSCNT+
Sbjct: 516 NIPQA--GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTED 573
Query: 612 CPLGSR-DFREKQCADFDNMPFRGKYY----NWKP-YTGGGVK-PCALNCLAEGYNFYTE 664
CP GS FRE+QCA +++ K + +W P YTG + C L C A+ +Y
Sbjct: 574 CPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYV 633
Query: 665 RAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFN 724
P V+DGT C+ DS +C+ G C H GCD I+GS + D+C VCGGDGS C G F
Sbjct: 634 LEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFR 693
Query: 725 DSLPRGGYMEVVQIPRGSVHIEVREVAMSKN---YIALKSEGDDYYINGAWTIDWPRKFD 781
R GY VV IP G+ HI VR+ + Y+ALK Y +NG +T+ P D
Sbjct: 694 KF--RYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTL-MPSPTD 750
Query: 782 V---AGTAFHYKRPTDEPESLEALGPTSENLIVMVLL--QEQNLGIRYKFNVP 829
V + Y T E+L GP ++ L + VL+ Q+ +RY F VP
Sbjct: 751 VVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVP 803
Score = 39.7 bits (91), Expect = 0.016
Identities = 21/53 (39%), Positives = 25/53 (47%), Gaps = 5/53 (9%)
Query: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
PW +CS TC GGVQ C R + YC+ R+CNTE CP
Sbjct: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRN--GGKYCEGRR---TRFRSCNTEDCP 575
Score = 33.1 bits (74), Expect = 1.5
Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 16/91 (17%)
Query: 906 GDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVA 965
G W +CS+TC GG++ + C R + + + + R CN + C P A
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE------GRRTRFRSCNTEDC-PTGSA 579
Query: 966 LDWSECTPKCGPGFKHRIVLCKSSDLSKTFP 996
L + E +C + HR +DL K+FP
Sbjct: 580 LTFRE--EQCA-AYNHR------TDLFKSFP 601
Score = 33.1 bits (74), Expect = 1.5
Identities = 19/59 (32%), Positives = 23/59 (38%), Gaps = 11/59 (18%)
Query: 1025 GDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEEC 1083
G WG CS CG G Q +S DC V + CE + NTE+C
Sbjct: 527 GPWGDCSRTCGGGVQF-----------SSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDC 574
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 412 bits (1059), Expect = e-115
Identities = 284/878 (32%), Positives = 428/878 (48%), Gaps = 96/878 (10%)
Query: 81 AVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDF-LDNCHYTGYLQD 139
+ +L LSA+GK F L L + F++ F +E G G + L C ++G +
Sbjct: 49 SAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNG 108
Query: 140 QRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQR 199
+ + A+S C GL G + EE+ I+P + PH + + R
Sbjct: 109 EPESL-AAVSLCRGLSGSFLLDGEEFTIQP--------QGAGGSLAQPHRLQRWGPAGAR 159
Query: 200 HLYDHSHCGVS--DFTRSGKPWWLNDTSTVSY-------SLPINNTHIHHRQKRSVSIER 250
L V + R + D+ S S P R KR VS R
Sbjct: 160 PLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEAR 219
Query: 251 FVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQP 310
FVETL+VAD M ++G D++++IL++M++ A++Y+ S+ N +N++V +++++ +++
Sbjct: 220 FVETLLVADASMAAFYGA-DLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKW 278
Query: 311 NLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCG 370
E++ + +L +FC WQ+ + SD + PE H+D A+L+TR + C + C
Sbjct: 279 GPEVSDNGGLTLRNFCNWQRRF-NQPSDRH--PE----HYDTAILLTRQNFCGQEGL-CD 330
Query: 371 TLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKL 430
TLG+A + +C+P +SCS+ ED GL +A T+AHE+GH M HD G
Sbjct: 331 TLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHH 390
Query: 431 MAAHITANTNP-FSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQV--YDAD 487
+ A + + N WS CS Y+T LD G G CL + P P PG++ Y D
Sbjct: 391 VMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCL-LDAPAAALPLPTGLPGRMALYQLD 449
Query: 488 EQCRFQYGATSRQC---KYGEVCRELWCLSKSNR--CVTN--SIPAAEGTLCQTGNIEKG 540
+QCR +G R C +VC +LWC + C T S+P A+GT C G++
Sbjct: 450 QQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHL--- 506
Query: 541 WCYQGDCVPFGTW--PQSI-DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
C +G C+P P+ + DGGW PW WGECSRTCGGGV S R C P P GG+YC
Sbjct: 507 -CSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYC 565
Query: 598 LGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFR---GKYYNWKPYTGGGVKP---CA 651
LG R +Y+SC+T+ CP + FRE+QC ++ + G W P GV P C
Sbjct: 566 LGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVP-KYAGVSPRDRCK 624
Query: 652 LNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGG 711
L C A G + + VIDGT C ++L IC+ G+C GCD+++ S + D+C VCGG
Sbjct: 625 LFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGG 684
Query: 712 DGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVRE-----VAMSKNYIALKSEGDDY 766
G++C + G + GY ++V IP G+ +I+V++ V NY+ALK+ Y
Sbjct: 685 KGNSCRKVSGSLTPT--NYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQY 742
Query: 767 YINGAWTID-WPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNL---GI 822
+NG I + V GT Y E L++ P E L V +L + +
Sbjct: 743 LLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKV 802
Query: 823 RYKFNVPITRTGSGDNEVGFT--------------------WNHQPWSECSATCAGGVQR 862
+Y F VP N+V F+ W WSECS+TC G QR
Sbjct: 803 KYTFFVP--------NDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQR 854
Query: 863 QEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
+ V C+ D S + C+ K PE+ + C ++ CP
Sbjct: 855 RTVECR---DPSGQASATCNKALK-PEDAKPCESQLCP 888
Score = 62.0 bits (149), Expect = 3e-09
Identities = 24/51 (47%), Positives = 35/51 (68%)
Query: 1021 RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESK 1071
+WV GDW +CS+ CG G Q RTV+C +GQAS+ C + ++P + CES+
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQ 885
Score = 46.6 bits (109), Expect = 1e-04
Identities = 25/59 (42%), Positives = 31/59 (52%), Gaps = 7/59 (11%)
Query: 962 QWVALDWSECTPKCGPGFKHRIVLCK--SSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
QWV DWSEC+ CG G++ R V C+ S S T A PE++KP C CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKP-----CESQLCP 888
Score = 42.0 bits (97), Expect = 0.003
Identities = 22/55 (40%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPE 902
PW ECS TC GGVQ CK D YC ++C+TE CPP+
Sbjct: 534 PWGECSRTCGGGVQFSHRECK--DPEPQNGGRYC---LGRRAKYQSCHTEECPPD 583
Score = 33.5 bits (75), Expect = 1.2
Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 6/66 (9%)
Query: 906 GDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVA 965
G W ECS+TC GG++ C P + Y CL R + + C+ + CPP +
Sbjct: 533 GPWGECSRTCGGGVQFSHREC---KDPEPQNGGRY--CLGRR-AKYQSCHTEECPPDGKS 586
Query: 966 LDWSEC 971
+C
Sbjct: 587 FREQQC 592
Score = 33.1 bits (74), Expect = 1.5
Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 19/81 (23%)
Query: 965 ALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVT 1024
+L W++ TP CGPG LC PEE + G P W
Sbjct: 492 SLPWADGTP-CGPGH-----LCSEGSC--------LPEEEVERPKPVADGGWAP---W-- 532
Query: 1025 GDWGQCSAQCGLGQQMRTVQC 1045
G WG+CS CG G Q +C
Sbjct: 533 GPWGECSRTCGGGVQFSHREC 553
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 363 bits (933), Expect = e-100
Identities = 202/538 (37%), Positives = 273/538 (50%), Gaps = 70/538 (13%)
Query: 561 WGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFR 620
WGPWS W CSRTCGGGVS R C S GG C+G + +RSC T+ CP G+RDFR
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSS-CVGPARSHRSCRTESCPDGARDFR 87
Query: 621 EKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSL 680
+QCA+FD F+G+ Y W PY K C LNC+ +G NFY + AV+DGT C
Sbjct: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNK-CELNCIPKGENFYYKHREAVVDGTPCEPGKR 146
Query: 681 DICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFN-DSLPRGGYMEVVQIP 739
D+C++G C+ VGCD+ L S +ED+C CGGDG+TC + G F+ + L R
Sbjct: 147 DVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSR---------- 196
Query: 740 RGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTD---EP 796
A+K+ +YY+NG WTI+ R A T HY+R + P
Sbjct: 197 ------------------AVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
Query: 797 ESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATC 856
E L A GPTSE L++ ++ QE N G+ Y++++P+ R GF+W+H WS+CSA C
Sbjct: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSP-----GFSWSHGSWSDCSAEC 293
Query: 857 AGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP--PEWFIGDWLECSKT 914
GG Q + V C D+ ++ C +P + +R+CN PCP W G W CS +
Sbjct: 294 GGGHQSRLVFC--TIDHEAYPDHMCQRQPRPAD-RRSCNLHPCPETKRWKAGPWAPCSAS 350
Query: 915 CDGGMRTRAVLCIRKIGPSEEETLDYSGC--LTHRPVEKEPCNNQSCPPQWVALDWSECT 972
C GG ++R+V CI G +E ++ + C L +P + CN Q C W W EC+
Sbjct: 351 CGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AAWSPEPWGECS 409
Query: 973 PKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP---PPRWVTGDWGQ 1029
CG G + R V C+ S AA C E +PP+ C CP W G WG
Sbjct: 410 VSCGVGVRKRSVTCRGERGSLLHTAA-CSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGL 468
Query: 1030 CSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPIS----NTEEC 1083
CS C G + R V C + PPS C S S P+ NT+ C
Sbjct: 469 CSKSCSSGTRRRQVIC-------------AIGPPS--HCGSLQHSKPVDVEPCNTQPC 511
Score = 36.2 bits (82), Expect = 0.18
Identities = 17/68 (25%), Positives = 28/68 (41%)
Query: 1047 SYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYF 1106
SYT A R ++ + P +C D ++A C L+L+ + C Y+
Sbjct: 1172 SYTCSAYQGSQAVSRSTEVKVVSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYY 1231
Query: 1107 RQMCCKTC 1114
CC +C
Sbjct: 1232 SSFCCASC 1239
Score = 33.5 bits (75), Expect = 1.2
Identities = 22/73 (30%), Positives = 26/73 (35%), Gaps = 7/73 (9%)
Query: 542 CYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGER 601
C DC P D W + WG CS++C G C PS G +
Sbjct: 448 CVHEDC------PLLSDQAWHVGT-WGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKP 500
Query: 602 KRYRSCNTDPCPL 614
CNT PC L
Sbjct: 501 VDVEPCNTQPCHL 513
Score = 32.0 bits (71), Expect = 3.4
Identities = 17/59 (28%), Positives = 21/59 (35%)
Query: 1027 WGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKD 1085
W CS CG G R C S S C+ R + ES D E+C +
Sbjct: 35 WSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCAE 93
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 345 bits (886), Expect = 1e-94
Identities = 254/844 (30%), Positives = 371/844 (43%), Gaps = 93/844 (11%)
Query: 241 RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA 300
RQ+R+ +E LV + H ++D E Y+L+ +NI A+L RD SLG + +
Sbjct: 71 RQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHLV 129
Query: 301 RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD 360
++++LTE + I + SL S C W ++I N + H D + ITR+D
Sbjct: 130 KMVILTEPEGAPNITANLTSSLLSVCGWSQTI-------NPEDDTDPGHADLVLYITRFD 182
Query: 361 ICTYKNKPCGTL---GLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGI- 416
+ P G G+ + G C P SC I ED G TIAHEIGH+FG+ HDG
Sbjct: 183 L----ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAP 238
Query: 417 GNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEP---PKRDF 473
G+ CG GH +MA+ A +WS CSR + S L +GR C+ + P P
Sbjct: 239 GSGCGPSGH----VMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 474 LYPAVAPGQVYDADEQCRFQYGATSRQCKYG----EVCRELWCLSK---SNRCVTNSIPA 526
P PG Y A+EQCR +G + C + ++C+ L C + + C +P
Sbjct: 295 HPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPL 354
Query: 527 AEGTLCQTGNIEKGWCYQGDCVPFG--TWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRH 584
+GT C +EK WC +G C T ++ G W W CSR+CGGGV + R
Sbjct: 355 LDGTEC---GVEK-WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQ 410
Query: 585 CDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFR-----GKYYNW 639
C++P P+ GG+ C+G + CNT C +F +QCA D P R +Y+W
Sbjct: 411 CNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHW 470
Query: 640 ---KPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQC------NADSLDICINGECKH 690
P++ G C C A G +F +R + +DGT+C +L +C++G C+
Sbjct: 471 GAAVPHSQGDAL-CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRT 529
Query: 691 VGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREV 750
GCD + S DRC+VCGGD STC +G F R Y+ + + + +
Sbjct: 530 FGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAR-EYVTFLTVTPNLTSVYIANH 588
Query: 751 AMSKNYIALKSEGDDYYINGAWTID----WPRKFDVAGTAFHYKRPTDEPESLEAL---G 803
++A++ G Y + G +I +P + + D LE + G
Sbjct: 589 RPLFTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWG 647
Query: 804 PTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTW----NHQPW------SECS 853
P E+ + V + G Y +TR ++ FT+ Q W CS
Sbjct: 648 PLQEDADIQVY---RRYGEEYG---NLTRP-----DITFTYFQPKPRQAWVWAAVRGPCS 696
Query: 854 ATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSK 913
+C G++ C +V+ C +PP AC EPCPP W +GD+ CS
Sbjct: 697 VSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSA 756
Query: 914 TCDGGMRTRAVLCIRKIGPSEEETLDYSGC---LTHRPVEKEPCNNQSCPPQWVALDWSE 970
+C GG+R R V C+ G S +TL + C V E CN Q CP +W + S
Sbjct: 757 SCGGGLRERPVRCVEAQG-SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
Query: 971 CTPKCGPGFKHRIVLCKSSDLSKTFPAAQCP--EESKPPVRIRCSLGRCPPPRWVTGDWG 1028
CT G G C P + P + K P C CPP WG
Sbjct: 816 CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPP------GWG 869
Query: 1029 QCSA 1032
A
Sbjct: 870 HLDA 873
Score = 106 bits (265), Expect = 1e-22
Identities = 72/244 (29%), Positives = 97/244 (39%), Gaps = 13/244 (5%)
Query: 832 RTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQ 891
RTG+ + W S CS +C G+ +C VQ C SKP +
Sbjct: 888 RTGA---QAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRR 943
Query: 892 RACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIG--PSEEETLDYSGCLTHRPV 949
C PCP W CS +C G+ R + C R G EE LD RP
Sbjct: 944 EVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 1002
Query: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPA--AQCPEESKPP 1007
+E C+ + CPP+W + C+ CG G R V C D + A C +P
Sbjct: 1003 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1062
Query: 1008 VRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA---SSDCLETVRPPS 1064
+ C + C RW G W +CS CG G Q R CL QA + C +P +
Sbjct: 1063 ASVPCLIADC-TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVT 1121
Query: 1065 MQQC 1068
++ C
Sbjct: 1122 VRGC 1125
Score = 92.4 bits (228), Expect = 2e-18
Identities = 62/219 (28%), Positives = 87/219 (39%), Gaps = 23/219 (10%)
Query: 852 CSATCAGGVQRQEVVCKRL----DDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGD 907
CS +C GV R+ + C R D I+ + C +P E Q AC+ EPCPP W +
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRP-EPQEACSLEPCPPRWKVMS 1020
Query: 908 WLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLT-HRPVEKEPCNNQSCPPQWVAL 966
CS +C G R+V C+ ++ ++ +D + C RP PC C +W
Sbjct: 1021 LGPCSASCGLGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1079
Query: 967 DWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGD 1026
W EC+ CG G + R C PA C P P V G
Sbjct: 1080 TWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQ--------------HLPKPVTVRGC 1125
Query: 1027 W-GQCSAQCGLGQQ-MRTVQCLSYTGQASSDCLETVRPP 1063
W G C Q G+Q + + G +DC + P
Sbjct: 1126 WAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAIGRP 1164
Score = 65.1 bits (157), Expect = 4e-10
Identities = 40/140 (28%), Positives = 59/140 (42%), Gaps = 6/140 (4%)
Query: 911 CSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSE 970
CS +C G+R C+ + ET+ G P E C + CPP W D+
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGS-QQPPAWPEACVLEPCPPYWAVGDFGP 753
Query: 971 CTPKCGPGFKHRIVLCKSSD--LSKTFPAAQCPEESKPPVRI--RCSLGRCPPPRWVTGD 1026
C+ CG G + R V C + L KT P A+C ++ P C+ CP RW +
Sbjct: 754 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA-RWEVSE 812
Query: 1027 WGQCSAQCGLGQQMRTVQCL 1046
C++ G G + C+
Sbjct: 813 PSSCTSAGGAGLALENETCV 832
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/101 (32%), Positives = 45/101 (44%), Gaps = 7/101 (6%)
Query: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIR-CSLGRCPPPR 1021
W A+ C+ CG G + C + QC +PP C L CPP
Sbjct: 688 WAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPP-Y 745
Query: 1022 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRP 1062
W GD+G CSA CG G + R V+C+ +A L+T+ P
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCV----EAQGSLLKTLPP 782
Score = 38.1 bits (87), Expect = 0.047
Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 1/58 (1%)
Query: 842 FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
+ W+ W ECS +C G+QR+ C + V ++C K P R C PC
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPK-PVTVRGCWAGPC 1130
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 345 bits (886), Expect = 1e-94
Identities = 254/844 (30%), Positives = 371/844 (43%), Gaps = 93/844 (11%)
Query: 241 RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA 300
RQ+R+ +E LV + H ++D E Y+L+ +NI A+L RD SLG + +
Sbjct: 71 RQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHLV 129
Query: 301 RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD 360
++++LTE + I + SL S C W ++I N + H D + ITR+D
Sbjct: 130 KMVILTEPEGAPNITANLTSSLLSVCGWSQTI-------NPEDDTDPGHADLVLYITRFD 182
Query: 361 ICTYKNKPCGTL---GLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGI- 416
+ P G G+ + G C P SC I ED G TIAHEIGH+FG+ HDG
Sbjct: 183 L----ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAP 238
Query: 417 GNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEP---PKRDF 473
G+ CG GH +MA+ A +WS CSR + S L +GR C+ + P P
Sbjct: 239 GSGCGPSGH----VMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG 294
Query: 474 LYPAVAPGQVYDADEQCRFQYGATSRQCKYG----EVCRELWCLSK---SNRCVTNSIPA 526
P PG Y A+EQCR +G + C + ++C+ L C + + C +P
Sbjct: 295 HPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPL 354
Query: 527 AEGTLCQTGNIEKGWCYQGDCVPFG--TWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRH 584
+GT C +EK WC +G C T ++ G W W CSR+CGGGV + R
Sbjct: 355 LDGTEC---GVEK-WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQ 410
Query: 585 CDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFR-----GKYYNW 639
C++P P+ GG+ C+G + CNT C +F +QCA D P R +Y+W
Sbjct: 411 CNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHW 470
Query: 640 ---KPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQC------NADSLDICINGECKH 690
P++ G C C A G +F +R + +DGT+C +L +C++G C+
Sbjct: 471 GAAVPHSQGDAL-CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRT 529
Query: 691 VGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREV 750
GCD + S DRC+VCGGD STC +G F R Y+ + + + +
Sbjct: 530 FGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAR-EYVTFLTVTPNLTSVYIANH 588
Query: 751 AMSKNYIALKSEGDDYYINGAWTID----WPRKFDVAGTAFHYKRPTDEPESLEAL---G 803
++A++ G Y + G +I +P + + D LE + G
Sbjct: 589 RPLFTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWG 647
Query: 804 PTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTW----NHQPW------SECS 853
P E+ + V + G Y +TR ++ FT+ Q W CS
Sbjct: 648 PLQEDADIQVY---RRYGEEYG---NLTRP-----DITFTYFQPKPRQAWVWAAVRGPCS 696
Query: 854 ATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSK 913
+C G++ C +V+ C +PP AC EPCPP W +GD+ CS
Sbjct: 697 VSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSA 756
Query: 914 TCDGGMRTRAVLCIRKIGPSEEETLDYSGC---LTHRPVEKEPCNNQSCPPQWVALDWSE 970
+C GG+R R V C+ G S +TL + C V E CN Q CP +W + S
Sbjct: 757 SCGGGLRERPVRCVEAQG-SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
Query: 971 CTPKCGPGFKHRIVLCKSSDLSKTFPAAQCP--EESKPPVRIRCSLGRCPPPRWVTGDWG 1028
CT G G C P + P + K P C CPP WG
Sbjct: 816 CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPP------GWG 869
Query: 1029 QCSA 1032
A
Sbjct: 870 HLDA 873
Score = 106 bits (265), Expect = 1e-22
Identities = 72/244 (29%), Positives = 97/244 (39%), Gaps = 13/244 (5%)
Query: 832 RTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQ 891
RTG+ + W S CS +C G+ +C VQ C SKP +
Sbjct: 888 RTGA---QAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRR 943
Query: 892 RACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPS--EEETLDYSGCLTHRPV 949
C PCP W CS +C G+ R + C R G EE LD RP
Sbjct: 944 EVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 1002
Query: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPA--AQCPEESKPP 1007
+E C+ + CPP+W + C+ CG G R V C D + A C +P
Sbjct: 1003 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1062
Query: 1008 VRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA---SSDCLETVRPPS 1064
+ C + C RW G W +CS CG G Q R CL QA + C +P +
Sbjct: 1063 ASVPCLIADCTY-RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVT 1121
Query: 1065 MQQC 1068
++ C
Sbjct: 1122 VRGC 1125
Score = 90.1 bits (222), Expect = 1e-17
Identities = 53/171 (30%), Positives = 73/171 (42%), Gaps = 7/171 (4%)
Query: 852 CSATCAGGVQRQEVVCKRL----DDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGD 907
CS +C GV R+ + C R D I+ + C +P E Q AC+ EPCPP W +
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRP-EPQEACSLEPCPPRWKVMS 1020
Query: 908 WLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLT-HRPVEKEPCNNQSCPPQWVAL 966
CS +C G R+V C+ ++ ++ +D + C RP PC C +W
Sbjct: 1021 LGPCSASCGLGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1079
Query: 967 DWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 1017
W EC+ CG G + R C PA C KP C G C
Sbjct: 1080 TWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 65.1 bits (157), Expect = 4e-10
Identities = 40/140 (28%), Positives = 59/140 (42%), Gaps = 6/140 (4%)
Query: 911 CSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSE 970
CS +C G+R C+ + ET+ G P E C + CPP W D+
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGS-QQPPAWPEACVLEPCPPYWAVGDFGP 753
Query: 971 CTPKCGPGFKHRIVLCKSSD--LSKTFPAAQCPEESKPPVRI--RCSLGRCPPPRWVTGD 1026
C+ CG G + R V C + L KT P A+C ++ P C+ CP RW +
Sbjct: 754 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA-RWEVSE 812
Query: 1027 WGQCSAQCGLGQQMRTVQCL 1046
C++ G G + C+
Sbjct: 813 PSSCTSAGGAGLALENETCV 832
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/101 (32%), Positives = 45/101 (44%), Gaps = 7/101 (6%)
Query: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIR-CSLGRCPPPR 1021
W A+ C+ CG G + C + QC +PP C L CPP
Sbjct: 688 WAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPP-Y 745
Query: 1022 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRP 1062
W GD+G CSA CG G + R V+C+ +A L+T+ P
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCV----EAQGSLLKTLPP 782
Score = 38.1 bits (87), Expect = 0.047
Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 1/58 (1%)
Query: 842 FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
+ W+ W ECS +C G+QR+ C + V ++C K P R C PC
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPK-PVTVRGCWAGPC 1130
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 321 bits (823), Expect = 2e-87
Identities = 245/841 (29%), Positives = 359/841 (42%), Gaps = 118/841 (14%)
Query: 241 RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA 300
RQ+R+ +E LV + H ++D E Y+L+ +NI A+L RD SLG + +
Sbjct: 71 RQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHLV 129
Query: 301 RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD 360
++++LTE + I + SL S C W ++I N + H D + ITR+D
Sbjct: 130 KMVILTEPEGAPNITANLTSSLLSVCGWSQTI-------NPEDDTDPGHADLVLYITRFD 182
Query: 361 ICTYKNKPCGTL---GLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGI- 416
+ P G G+ + G C P SC I ED G TIAHEIGH+FG+ HDG
Sbjct: 183 L----ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAP 238
Query: 417 GNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYP 476
G+ CG GH +MA+ A +WS CSR + S L
Sbjct: 239 GSGCGPSGH----VMASDGAAPRAGLAWSPCSRRQLLSLLS------------------- 275
Query: 477 AVAPGQVYDADEQCRFQYGATSRQCKYG----EVCRELWCLSK---SNRCVTNSIPAAEG 529
A+EQCR +G + C + ++C+ L C + + C +P +G
Sbjct: 276 ---------ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDG 326
Query: 530 TLCQTGNIEKGWCYQGDCVPFG--TWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDS 587
T C +EK WC +G C T ++ G W W CSR+CGGGV + R C++
Sbjct: 327 TEC---GVEK-WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNN 382
Query: 588 PAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFR-----GKYYNW--- 639
P P+ GG+ C+G + CNT C +F +QCA D P R +Y+W
Sbjct: 383 PRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAA 442
Query: 640 KPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQC------NADSLDICINGECKHVGC 693
P++ G C C A G +F +R + +DGT+C +L +C++G C+ GC
Sbjct: 443 VPHSQGDAL-CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGC 501
Query: 694 DNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMS 753
D + S DRC+VCGGD STC +G F R Y+ + + + +
Sbjct: 502 DGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAR-EYVTFLTVTPNLTSVYIANHRPL 560
Query: 754 KNYIALKSEGDDYYINGAWTID----WPRKFDVAGTAFHYKRPTDEPESLEAL---GPTS 806
++A++ G Y + G +I +P + + D LE + GP
Sbjct: 561 FTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQ 619
Query: 807 ENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTW----NHQPW------SECSATC 856
E+ + V + G Y +TR ++ FT+ Q W CS +C
Sbjct: 620 EDADIQVY---RRYGEEYG---NLTRP-----DITFTYFQPKPRQAWVWAAVRGPCSVSC 668
Query: 857 AGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCD 916
G++ C +V+ C +PP AC EPCPP W +GD+ CS +C
Sbjct: 669 GAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG 728
Query: 917 GGMRTRAVLCIRKIGPSEEETLDYSGC---LTHRPVEKEPCNNQSCPPQWVALDWSECTP 973
GG+R R V C+ G S +TL + C V E CN Q CP +W + S CT
Sbjct: 729 GGLRERPVRCVEAQG-SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTS 787
Query: 974 KCGPGFKHRIVLCKSSDLSKTFPAAQCP--EESKPPVRIRCSLGRCPPPRWVTGDWGQCS 1031
G G C P + P + K P C CPP WG
Sbjct: 788 AGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPP------GWGHLD 841
Query: 1032 A 1032
A
Sbjct: 842 A 842
Score = 106 bits (265), Expect = 1e-22
Identities = 72/244 (29%), Positives = 97/244 (39%), Gaps = 13/244 (5%)
Query: 832 RTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQ 891
RTG+ + W S CS +C G+ +C VQ C SKP +
Sbjct: 857 RTGA---QAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRR 912
Query: 892 RACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIG--PSEEETLDYSGCLTHRPV 949
C PCP W CS +C G+ R + C R G EE LD RP
Sbjct: 913 EVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 971
Query: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPA--AQCPEESKPP 1007
+E C+ + CPP+W + C+ CG G R V C D + A C +P
Sbjct: 972 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1031
Query: 1008 VRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA---SSDCLETVRPPS 1064
+ C + C RW G W +CS CG G Q R CL QA + C +P +
Sbjct: 1032 ASVPCLIADC-TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVT 1090
Query: 1065 MQQC 1068
++ C
Sbjct: 1091 VRGC 1094
Score = 92.4 bits (228), Expect = 2e-18
Identities = 62/219 (28%), Positives = 87/219 (39%), Gaps = 23/219 (10%)
Query: 852 CSATCAGGVQRQEVVCKRL----DDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGD 907
CS +C GV R+ + C R D I+ + C +P E Q AC+ EPCPP W +
Sbjct: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRP-EPQEACSLEPCPPRWKVMS 989
Query: 908 WLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLT-HRPVEKEPCNNQSCPPQWVAL 966
CS +C G R+V C+ ++ ++ +D + C RP PC C +W
Sbjct: 990 LGPCSASCGLGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1048
Query: 967 DWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGD 1026
W EC+ CG G + R C PA C P P V G
Sbjct: 1049 TWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQ--------------HLPKPVTVRGC 1094
Query: 1027 W-GQCSAQCGLGQQ-MRTVQCLSYTGQASSDCLETVRPP 1063
W G C Q G+Q + + G +DC + P
Sbjct: 1095 WAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAIGRP 1133
Score = 65.1 bits (157), Expect = 4e-10
Identities = 40/140 (28%), Positives = 59/140 (42%), Gaps = 6/140 (4%)
Query: 911 CSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSE 970
CS +C G+R C+ + ET+ G P E C + CPP W D+
Sbjct: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGS-QQPPAWPEACVLEPCPPYWAVGDFGP 722
Query: 971 CTPKCGPGFKHRIVLCKSSD--LSKTFPAAQCPEESKPPVRI--RCSLGRCPPPRWVTGD 1026
C+ CG G + R V C + L KT P A+C ++ P C+ CP RW +
Sbjct: 723 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA-RWEVSE 781
Query: 1027 WGQCSAQCGLGQQMRTVQCL 1046
C++ G G + C+
Sbjct: 782 PSSCTSAGGAGLALENETCV 801
Score = 54.7 bits (130), Expect = 5e-07
Identities = 33/101 (32%), Positives = 45/101 (44%), Gaps = 7/101 (6%)
Query: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIR-CSLGRCPPPR 1021
W A+ C+ CG G + C + QC +PP C L CPP
Sbjct: 657 WAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPP-Y 714
Query: 1022 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRP 1062
W GD+G CSA CG G + R V+C+ +A L+T+ P
Sbjct: 715 WAVGDFGPCSASCGGGLRERPVRCV----EAQGSLLKTLPP 751
Score = 38.1 bits (87), Expect = 0.047
Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 1/58 (1%)
Query: 842 FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
+ W+ W ECS +C G+QR+ C + V ++C K P R C PC
Sbjct: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPK-PVTVRGCWAGPC 1099
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 302 bits (774), Expect = 1e-81
Identities = 184/537 (34%), Positives = 256/537 (47%), Gaps = 47/537 (8%)
Query: 569 ECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFD 628
E S G G + + PA S C+G ++Y+ CNT+ CP SR RE QCA ++
Sbjct: 264 ETSNNHGVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASYN 322
Query: 629 NMPFRGKYYNWKPYTG-GGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGE 687
N PF G++Y W+P+ G + C LNC A GY FY +A VIDGT C+ + IC++G+
Sbjct: 323 NKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQ 382
Query: 688 CKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEV 747
CK +GCD+ LGSD D+C VCGGD + C + G F +L GY VV+IP G+ I +
Sbjct: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
Query: 748 REVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTD----EPESLEALG 803
E+ S NY+AL+S ING W ID P K++ GT F YKRP + ES A G
Sbjct: 443 TEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEG 502
Query: 804 PTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGD----NEVGFTWNHQPWSECSATCAGG 859
PT+E L V ++ Q+ N G+ Y++ + T S G +N Q +E + G
Sbjct: 503 PTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGE 562
Query: 860 VQRQEVVCKRLDDNSIVQ----------------------NNYCDPDSKPPENQRACNTE 897
+ + + L + +N P +PP R N
Sbjct: 563 QKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHN-- 620
Query: 898 PCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQ 957
W ECS TC G + C+ + EE Y E+EPCN
Sbjct: 621 -----WKQLGTTECSTTCGKGSQYPIFRCVHR-STHEEAPESYCDSSMKPTPEEEPCNIF 674
Query: 958 SCPPQWVALDWSECTPKCGPGFKHRIVLCKS--SDLSKTFPAAQCPEESKPPVRIRCSLG 1015
CP W +WSEC+ CG G +HR VLC+ ++ S T +C KP C L
Sbjct: 675 PCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLK 734
Query: 1016 RCPPPRW-VTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSD--CLETVRPPSMQQCE 1069
C W + DW CS CG+GQ+ R V+C+S G D C +RP ++ C+
Sbjct: 735 IC--SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCD 789
Score = 153 bits (387), Expect = 8e-37
Identities = 85/271 (31%), Positives = 137/271 (50%), Gaps = 16/271 (5%)
Query: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDW 908
W+ CS C G + ++V C + +V + C+ +P + + C+ PC WF+ +W
Sbjct: 745 WTSCSVPCGVGQRTRDVKCVS-NIGDVVDDEECNMKLRPNDIEN-CDMGPCAKSWFLTEW 802
Query: 909 LE-CSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPP--QWVA 965
E CS C G+RTR+V+C+ + +L GC +RP E PC+N C +W A
Sbjct: 803 SERCSAECGAGVRTRSVVCMT----NHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFA 858
Query: 966 LDWSECTPKCGPGFKHRIVLC--KSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
WS+C+ +CG G + R V+C K++D + ++C KPP + C L C +W
Sbjct: 859 GSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGA-KWF 917
Query: 1024 TGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEEC 1083
+ +W CS C G ++R V+CLS S+ C ++P + C + D P E C
Sbjct: 918 STEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQ-DCVP-EVDENC 975
Query: 1084 KDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
KD K C +V++ + C Y++ CC +C
Sbjct: 976 KD--KYYNCNVVVQARLCVYNYYKTACCASC 1004
Score = 124 bits (312), Expect = 4e-28
Identities = 75/232 (32%), Positives = 105/232 (45%), Gaps = 10/232 (4%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
W +ECS TC G Q C + +YCD KP + CN PCP W
Sbjct: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFW 680
Query: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-THRPVEKEPCNNQSCPPQ 962
IG+W ECSKTC GM+ R VLC R++ + T+ C +P C + C
Sbjct: 681 DIGEWSECSKTCGLGMQHRQVLC-RQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEW 739
Query: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRW 1022
+ DW+ C+ CG G + R V C S++ +C + +P C +G C W
Sbjct: 740 QIRTDWTSCSVPCGVGQRTRDVKC-VSNIGDVVDDEECNMKLRPNDIENCDMGPC-AKSW 797
Query: 1023 VTGDWGQ-CSAQCGLGQQMRTVQCLSYTGQASSDCLE---TVRPPSMQQCES 1070
+W + CSA+CG G + R+V C+ T SS LE RP C++
Sbjct: 798 FLTEWSERCSAECGAGVRTRSVVCM--TNHVSSLPLEGCGNNRPAEATPCDN 847
Score = 100 bits (249), Expect = 8e-21
Identities = 59/181 (32%), Positives = 85/181 (46%), Gaps = 11/181 (6%)
Query: 843 TWNHQPWSE-CSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901
+W WSE CSA C GV+ + VVC +S+ + P C+ PC
Sbjct: 796 SWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGC---GNNRPAEATPCDNGPCTG 852
Query: 902 --EWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGC-LTHRPVEKEPCNNQS 958
EWF G W +CS C G + R V+C+RK E LD S C +P ++ C+ +
Sbjct: 853 KVEWFAGSWSQCSIECGSGTQQREVICVRK-NADTFEVLDPSECSFLEKPPSQQSCHLKP 911
Query: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
C +W + +WS C+ C GF+ R V C S D++ + C + KP R C+ C
Sbjct: 912 CGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTL---SNLCDPQLKPEERESCNPQDCV 968
Query: 1019 P 1019
P
Sbjct: 969 P 969
Score = 91.7 bits (226), Expect = 4e-18
Identities = 45/121 (37%), Positives = 66/121 (54%), Gaps = 8/121 (6%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVC--KRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901
W WS+CS C G Q++EV+C K D ++ + C KPP +Q++C+ +PC
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPP-SQQSCHLKPCGA 914
Query: 902 EWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPP 961
+WF +W CSK+C GG R R V C+ S++ TL +P E+E CN Q C P
Sbjct: 915 KWFSTEWSMCSKSCQGGFRVREVRCL-----SDDMTLSNLCDPQLKPEERESCNPQDCVP 969
Query: 962 Q 962
+
Sbjct: 970 E 970
Score = 50.4 bits (119), Expect = 9e-06
Identities = 26/62 (41%), Positives = 35/62 (56%), Gaps = 4/62 (6%)
Query: 841 GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
G W WS CS +C GG + +EV C L D+ + +N CDP K PE + +CN + C
Sbjct: 913 GAKWFSTEWSMCSKSCQGGFRVREVRC--LSDD-MTLSNLCDPQLK-PEERESCNPQDCV 968
Query: 901 PE 902
PE
Sbjct: 969 PE 970
Score = 39.7 bits (91), Expect = 0.016
Identities = 14/27 (51%), Positives = 15/27 (55%)
Query: 559 GGWGPWSLWGECSRTCGGGVSSSLRHC 585
G WG W W CSR+C GGV R C
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 32.0 bits (71), Expect = 3.4
Identities = 15/34 (44%), Positives = 17/34 (50%), Gaps = 2/34 (5%)
Query: 834 GSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVC 867
G G V W PWS CS +C+GGV Q C
Sbjct: 49 GGGAPGVWGAWG--PWSACSRSCSGGVMEQTRPC 80
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 286 bits (733), Expect = 6e-77
Identities = 183/578 (31%), Positives = 266/578 (46%), Gaps = 99/578 (17%)
Query: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSR 617
DG W W W ECSRTCGGG S SLR C S K C G RYR+C+ CP +
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
Query: 618 DFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNA 677
DFR +QC+ +++ G++Y W P + PC+L C A+G E AP V+DGT+C
Sbjct: 87 DFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
Query: 678 DSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYME-VV 736
+SLD+CI+G C+ VGCD+ LGS +ED C VC GDGSTC + G + L + VV
Sbjct: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
Query: 737 QIPRGSVHIEVREVAMSKNYIALKS-EGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDE 795
IP GS HI + Y+ K+ +G G ++ F V ++ +++ D+
Sbjct: 207 AIPYGSRHIRLVLKGPDHLYLETKTLQG----TKGENSLSSTGTFLVDNSSVDFQKFPDK 262
Query: 796 PESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGF--------TWNHQ 847
E L GP + + I V I +GS D+ V F W
Sbjct: 263 -EILRMAGPLTADFI-----------------VKIRNSGSADSTVQFIFYQPIIHRWRET 304
Query: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCD--PDS-KPPENQRACNTEPCP---- 900
+ CSATC GG Q C L N +V + YC P++ KP + CN +PCP
Sbjct: 305 DFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDG 364
Query: 901 -------------PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-TH 946
P W W CS +C GG+++RAV C+ + +++ C+ T
Sbjct: 365 YKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTP 424
Query: 947 RPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKP 1006
+ +PCN C P+W+A +WS CT CG G ++R+VLC + C ++KP
Sbjct: 425 KMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCID---HRGMHTGGCSPKTKP 480
Query: 1007 PVRIRCSL--------------GRCP----------------PPRWVTGDWGQCSAQCGL 1036
++ C + + P P ++ W C+ CG+
Sbjct: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
Query: 1037 GQQMRTVQC---LSYTGQASS---DCLETVRPPSMQQC 1068
G Q+R V+C LS++ + D E +P S + C
Sbjct: 541 GTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRAC 578
Score = 150 bits (379), Expect = 6e-36
Identities = 74/217 (34%), Positives = 103/217 (47%), Gaps = 7/217 (3%)
Query: 834 GSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRA 893
G D + + W ++ +++CS +C GGVQ V C + N C +PP+ ++
Sbjct: 601 GLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKS 660
Query: 894 CNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSG--CLTHRPVEK 951
CN +PCP W IG W CS TC G++TR V C + ET+ + C +P
Sbjct: 661 CNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV 720
Query: 952 EPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTF---PAAQCPEESKPPV 1008
+ CN +CPP W W C+ CG G + R VLCK +F P C SKP
Sbjct: 721 QACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC-SASKPAC 779
Query: 1009 RIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC 1045
+ C C P W+ DW +CS CG G Q R+ C
Sbjct: 780 QQACKKDDC-PSEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 137 bits (346), Expect = 4e-32
Identities = 90/283 (31%), Positives = 134/283 (47%), Gaps = 22/283 (7%)
Query: 842 FTWNHQPWSECSATCAG-GVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
+ W+ + CSA+C GVQ+ + C L +++ V +C +P ACN CP
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 901 PEWFIGDWLECSKTCDGGMRTRAVLC--IRKIGPSEEETLDYSGCLTHRPVEKEPCNNQS 958
W + W C+++C GG++TR V C ++ G S + D + RPV+ + CN Q
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 959 CPPQWVALDWSECTPKC-GP--GFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLG 1015
C +W W +C C GP +HR V C++ D T P+ QC +P C
Sbjct: 1607 C-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD-GITLPSEQCSALPRPVSTQNCWSE 1664
Query: 1016 RCPPPRWVTGDWGQCSAQCG-LGQQMRTVQCL-SYTGQASSD--CLETVRPPSMQQCESK 1071
C W W C+A CG G Q R V+C+ + T +A + C RP + Q +
Sbjct: 1665 AC-SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQ----R 1719
Query: 1072 CDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
C+ TP N EC+D + YC V + K C + F+ CC TC
Sbjct: 1720 CNITPCENM-ECRDTTR--YCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 115 bits (289), Expect = 2e-25
Identities = 57/185 (30%), Positives = 85/185 (45%), Gaps = 10/185 (5%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRL-----DDNSIVQNNYCDPDSKPPENQRACNTEP 898
W WS CS TC G+Q ++V C L ++ I+ + C P +ACN
Sbjct: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPK--PSTVQACNRFN 727
Query: 899 CPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQS 958
CPP W+ W CS+TC GG++ R VLC +++ L + C +P ++ C
Sbjct: 728 CPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
Query: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCK---SSDLSKTFPAAQCPEESKPPVRIRCSLG 1015
CP +W+ DW+EC+ CG G + R +C+ + LS + CP C L
Sbjct: 788 CPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLA 847
Query: 1016 RCPPP 1020
C P
Sbjct: 848 TCARP 852
Score = 101 bits (252), Expect = 3e-21
Identities = 78/276 (28%), Positives = 111/276 (40%), Gaps = 43/276 (15%)
Query: 847 QPWSECSATCAGGVQRQEVVCKRL--DDNSIVQNNYCDPDSKPPENQRACNTEPCPPE-- 902
+ WS C+ TC G Q + V C+ L S+ + + P +QRAC PC E
Sbjct: 529 EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIP 588
Query: 903 ----------------------WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDY 940
W + +CS++C GG++ V C+ K E +
Sbjct: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK---QTREPAEE 645
Query: 941 SGCLTHR--PVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCK---SSDLSKT- 994
+ C+T R P + CN CP +W WS C+ CG G + R V C S ++++T
Sbjct: 646 NLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETV 705
Query: 995 FPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS- 1053
A + + KP C+ C PP W W CS CG G Q R V C S
Sbjct: 706 ILADELCRQPKPSTVQACNRFNC-PPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSF 764
Query: 1054 SDCLETVRPPSMQQCESKC--DSTP----ISNTEEC 1083
+ ET S C+ C D P +S+ EC
Sbjct: 765 LELPETFCSASKPACQQACKKDDCPSEWLLSDWTEC 800
Score = 38.5 bits (88), Expect = 0.036
Identities = 21/72 (29%), Positives = 28/72 (38%), Gaps = 2/72 (2%)
Query: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAG-GVQRQEVVCKRLDDNSIVQNNYCDPDSKP 887
P++ W W+ C+ATC G Q + V C N V + C +P
Sbjct: 1655 PVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRP 1714
Query: 888 PENQRACNTEPC 899
QR CN PC
Sbjct: 1715 ANWQR-CNITPC 1725
Score = 37.0 bits (84), Expect = 0.10
Identities = 28/91 (30%), Positives = 37/91 (40%), Gaps = 20/91 (21%)
Query: 542 CYQGDC---VPFGTWPQSIDGGWG---------PWSLWG--ECSRTCGGGVSSSLRHC-- 585
CY G C +P P DG +G W G +CS +CGGGV ++ C
Sbjct: 578 CYAGPCSGEIPEFN-PDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLN 636
Query: 586 DSPAPSGGGKYCLGERK---RYRSCNTDPCP 613
C+ R+ +SCN DPCP
Sbjct: 637 KQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
Score = 36.6 bits (83), Expect = 0.14
Identities = 30/127 (23%), Positives = 47/127 (37%), Gaps = 17/127 (13%)
Query: 493 QYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGT 552
++ S C G R+++C +R + ++ A+ Q C + +C P
Sbjct: 674 KWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP--- 730
Query: 553 WPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGG-----GKYCLGERKR-YRS 606
W P + W CSRTCGGGV C G +C + ++
Sbjct: 731 -------AWYP-AQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQA 782
Query: 607 CNTDPCP 613
C D CP
Sbjct: 783 CKKDDCP 789
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 285 bits (730), Expect = 1e-76
Identities = 175/579 (30%), Positives = 273/579 (47%), Gaps = 80/579 (13%)
Query: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSR 617
DG W W W +CSRTCGGG S SLR C + G+ C G+ RY++C+ CP +
Sbjct: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAE 128
Query: 618 DFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNA 677
DFR +QC+ ++++ ++G YY W P PCAL C A+G N E AP V+DGT+CN
Sbjct: 129 DFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNT 188
Query: 678 DSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSL-PRGGYMEVV 736
DSLD+CI+G C+ VGCD LGS+A+ED C VC GDGSTC + G + P V+
Sbjct: 189 DSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVI 248
Query: 737 QIPRGSVHIEVREVAMSKNYIALKS-EGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDE 795
+P GS + + + +I K+ +G G + + P F V T ++R + E
Sbjct: 249 AVPLGSRSVRITVKGPAHLFIESKTLQGS----KGEHSFNSPGVFLVENTTVEFQRGS-E 303
Query: 796 PESLEALGPTSENLIVMV-LLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSA 854
++ + GP + I ++ +++ F PI+ W + C+
Sbjct: 304 RQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISH----------QWRQTDFFPCTV 353
Query: 855 TCAGGVQRQEVVCKRLDDNSIVQNNYCD--PDS-KPPENQRACNTEPCP----------- 900
TC GG Q C + +V ++YC P++ KP + C+ +PCP
Sbjct: 354 TCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPY 413
Query: 901 ------PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-THRPVEKEP 953
P W W CS +C GG++ R+ +C+ + E ++ C+ +P +
Sbjct: 414 DHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQT 473
Query: 954 CNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSS----------------------DL 991
CN C P+W+A++WS+CT CG G ++R+VLC + +
Sbjct: 474 CNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPI 532
Query: 992 SKTFPAAQCPEESKPP-----VRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC- 1045
P + P E+K P + + P ++ W CS CG G Q+R V+C
Sbjct: 533 PCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCR 592
Query: 1046 --LSYT---GQASSDCLETVRPPSMQQC-ESKCDSTPIS 1078
L++T + + E + P+ + C CD +P S
Sbjct: 593 VLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPAS 631
Score = 151 bits (382), Expect = 3e-36
Identities = 88/266 (33%), Positives = 121/266 (45%), Gaps = 42/266 (15%)
Query: 790 KRPTDEPESLEAL--GPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQ 847
K PT+ P LEA P S L ++P+ D+E + W +
Sbjct: 613 KLPTERPCLLEACDESPASREL-----------------DIPLPE----DSETTYDWEYA 651
Query: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGD 907
++ C+ATC GG Q VC + V ++ CD +PP +ACNTEPCPP W +G
Sbjct: 652 GFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGS 711
Query: 908 WLECSKTCDGGMRTRAVLCI---RKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWV 964
W CS TC G++TR V C+ P EE C +P + CN CPP W
Sbjct: 712 WGPCSATCGVGIQTRDVYCLHPGETPAPPEE-------CRDEKPHALQACNQFDCPPGWH 764
Query: 965 ALDWSECTPKCGPGFKHRIVLCK-----SSDLSKTFPAAQCPEESKPPVRIRCSLGRCPP 1019
+W +C+ CG G ++R V C+ S L+ + Q P+ S C+ C P
Sbjct: 765 IEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASS---HKSCARTDC-P 820
Query: 1020 PRWVTGDWGQCSAQCGLGQQMRTVQC 1045
P GDW +CS CG+G Q R C
Sbjct: 821 PHLAVGDWSKCSVSCGVGIQRRKQVC 846
Score = 123 bits (308), Expect = 1e-27
Identities = 85/285 (29%), Positives = 117/285 (41%), Gaps = 36/285 (12%)
Query: 844 WNHQPWSECSATCA---GGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
W WS CSATC +QR + V + + V CD KP CN CP
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCV---MANGQEVSEALCDHLQKPLAGFEPCNIRDCP 1484
Query: 901 PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-THRPVEKEPCNNQSC 959
WF W +CS +C G +R V C R + + C RP+ ++PC C
Sbjct: 1485 ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Query: 960 PPQWVALDWSECTPKC---GPGFKHRIVLCK--SSDLSKTFPAAQCPEESKPPVRIRCSL 1014
QW + C +C + R C+ SSD + C + +P +R C+
Sbjct: 1545 -VQWE--PGNRCPGRCMGRAVRMQQRHTACQHNSSD-------SNCDDRKRPTLRRNCTS 1594
Query: 1015 GRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCL---SYTGQASSDCLETVRPPSMQQC-ES 1070
G C W TG W C+A CG G Q R V C+ S A C++ +P S + C
Sbjct: 1595 GAC-DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
Query: 1071 KCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 1115
CD +C D YC V CS ++Q CC++CQ
Sbjct: 1654 SCD-------RDCTDTTH--YCMFVKHLNLCSLDRYKQRCCQSCQ 1689
Score = 107 bits (267), Expect = 6e-23
Identities = 70/226 (30%), Positives = 98/226 (43%), Gaps = 29/226 (12%)
Query: 843 TWNHQPWSECSATCAGGVQRQEVVCKRL----DDNSIVQNNYCDPDSKPPENQ---RACN 895
T+ +PWS CS TC GVQ +EV C+ L + + C+ P E AC+
Sbjct: 567 TFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACD 626
Query: 896 TEPCPPE--------------WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYS 941
P E W + C+ TC GG + +C+ ++T++ S
Sbjct: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH---IQTQQTVNDS 683
Query: 942 GC-LTHR-PVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQ 999
C + HR P + CN + CPP+W W C+ CG G + R V C + P +
Sbjct: 684 LCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPA-PPEE 742
Query: 1000 CPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC 1045
C +E KP C+ C PP W +W QCS CG G Q R V C
Sbjct: 743 CRDE-KPHALQACNQFDC-PPGWHIEEWQQCSRTCGGGTQNRRVTC 786
Score = 97.8 bits (242), Expect = 5e-20
Identities = 56/193 (29%), Positives = 81/193 (41%), Gaps = 20/193 (10%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
W+ W CSATC G+Q ++V C + D + P +ACN CPP W
Sbjct: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD---EKPHALQACNQFDCPPGW 763
Query: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
I +W +CS+TC GG + R V C + + L C + + C CPP
Sbjct: 764 HIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHL 823
Query: 964 VALDWSECTPKCGPGFKHRIVLCK-----------SSDLSKTFP------AAQCPEESKP 1006
DWS+C+ CG G + R +C+ S + + P + Q PE SK
Sbjct: 824 AVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKI 883
Query: 1007 PVRIRCSLGRCPP 1019
++ LG P
Sbjct: 884 KSEMKTKLGEQGP 896
Score = 86.7 bits (213), Expect = 1e-16
Identities = 74/299 (24%), Positives = 115/299 (38%), Gaps = 61/299 (20%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVC----------------KRLDDNSIVQNNYCDPDSKP 887
W WS+C+ TC G++ + V+C + + ++ P K
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
Query: 888 P--------------ENQRACNTEPCPPEWFIGD-WLECSKTCDGGMRTRAVLCIRKIGP 932
P E R EP FI + W CS TC G++ R V C +
Sbjct: 542 PVEAKLPWLKQAQELEETRIATEEPT----FIPEPWSACSTTCGPGVQVREVKCRVLLTF 597
Query: 933 SEEET-LDYSGCLTHRPVEKEPCNNQSCPPQ-------------------WVALDWSECT 972
++ ET L C + + PC ++C W ++ CT
Sbjct: 598 TQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCT 657
Query: 973 PKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIR-CSLGRCPPPRWVTGDWGQCS 1031
C G + I +C +T + C +PP + C+ CPP RW G WG CS
Sbjct: 658 ATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP-RWHVGSWGPCS 716
Query: 1032 AQCGLGQQMRTVQCL--SYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNK 1088
A CG+G Q R V CL T +C + +P ++Q C ++ D P + EE + ++
Sbjct: 717 ATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQAC-NQFDCPPGWHIEEWQQCSR 773
Score = 36.2 bits (82), Expect = 0.18
Identities = 33/126 (26%), Positives = 43/126 (34%), Gaps = 23/126 (18%)
Query: 494 YGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW 553
+G S C G R+++CL PA C Q DC P
Sbjct: 712 WGPCSATCGVGIQTRDVYCLHPGET------PAPPEECRDEKPHALQACNQFDCPP---- 761
Query: 554 PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSG-----GGKYCLGER-KRYRSC 607
GW W +CSRTCGGG + C G + C G + ++SC
Sbjct: 762 ------GWHIEE-WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSC 814
Query: 608 NTDPCP 613
CP
Sbjct: 815 ARTDCP 820
Score = 34.3 bits (77), Expect = 0.68
Identities = 16/59 (27%), Positives = 21/59 (35%)
Query: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKP 887
P R W+ PW C+A C G Q ++V C V +C KP
Sbjct: 1586 PTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKP 1644
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 275 bits (704), Expect = 1e-73
Identities = 165/486 (33%), Positives = 235/486 (48%), Gaps = 63/486 (12%)
Query: 558 DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSR 617
DG W W W ECSRTCGGG S SLR C S K C G RYR+C+ CP +
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
Query: 618 DFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQCNA 677
DFR +QC+ +++ G++Y W P + PC+L C A+G E AP V+DGT+C
Sbjct: 87 DFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
Query: 678 DSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYME-VV 736
+SLD+CI+G C+ VGCD+ LGS +ED C VC GDGSTC + G + L + VV
Sbjct: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
Query: 737 QIPRGSVHIEVREVAMSKNYIALKS-EGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDE 795
IP GS HI + Y+ K+ +G G ++ F V ++ +++ D+
Sbjct: 207 AIPYGSRHIRLVLKGPDHLYLETKTLQG----TKGENSLSSTGTFLVDNSSVDFQKFPDK 262
Query: 796 PESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGF--------TWNHQ 847
E L GP + + I V I +GS D+ V F W
Sbjct: 263 -EILRMAGPLTADFI-----------------VKIRNSGSADSTVQFIFYQPIIHRWRET 304
Query: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCD--PDS-KPPENQRACNTEPCP---- 900
+ CSATC GG Q C L N +V + YC P++ KP + CN +PCP
Sbjct: 305 DFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDG 364
Query: 901 -------------PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCL-TH 946
P W W CS +C GG+++RAV C+ + +++ C+ T
Sbjct: 365 YKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTP 424
Query: 947 RPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKP 1006
+ +PCN C P+W+A +WS CT CG G ++R+VLC + C ++KP
Sbjct: 425 KMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCID---HRGMHTGGCSPKTKP 480
Query: 1007 PVRIRC 1012
++ C
Sbjct: 481 HIKEEC 486
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 270 bits (690), Expect = 6e-72
Identities = 183/577 (31%), Positives = 253/577 (43%), Gaps = 73/577 (12%)
Query: 523 SIPAAEGTLCQ----TGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGV 578
S+P G Q TG G + D G W + G SLW
Sbjct: 304 SVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLW----------- 352
Query: 579 SSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYN 638
SL SP P C GE ++ R+C+ PCP D R QCA F++ F G+ Y
Sbjct: 353 --SLFAPSSPIPR-----CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQ 405
Query: 639 WKPYTG-GGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNIL 697
W+P+T G + C LNC G+ FY V DGT C + DIC+ G C GCD IL
Sbjct: 406 WEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGIL 465
Query: 698 GSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYI 757
GS R D C VCGGD STC + G D GY +++ IP G++ +++ ++ S NY+
Sbjct: 466 GSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYL 525
Query: 758 ALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEP---ESLEALGPTSENLIVMVL 814
AL+ G ING W +D P + GT F Y RP E ESL A GPT++ + V ++
Sbjct: 526 ALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMI 585
Query: 815 LQEQNLGIRYKFNV----PITRTGSGDNEVGFTWNHQPW----------SECSATCAGGV 860
QE+N G+ Y++ + PI + + V QP + A G +
Sbjct: 586 FQEENPGVFYQYVISSPPPILENPTPEPPVP---QLQPEILRVEPPLAPAPRPARTPGTL 642
Query: 861 QRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMR 920
QRQ + P P + R P W CS +C G+
Sbjct: 643 QRQVRI----------------PQMPAPPHPRTPLGSPA-AYWKRVGHSACSASCGKGVW 685
Query: 921 TRAVLCIRKIGPSEEETLDYSGCL--THRPVEKEPCNNQSCPPQWVALDWSECTPKCGPG 978
LCI + E LD C P EPC+ CPP W A +W+ C+ CGPG
Sbjct: 686 RPIFLCISR---ESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPG 742
Query: 979 FKHRIVLCKS--SDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGD-WGQCSAQCG 1035
+HR + C+ + P +C +P + C L C W G W QCS +CG
Sbjct: 743 TQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC--GHWEVGSPWSQCSVRCG 800
Query: 1036 LGQQMRTVQCLSYTGQ--ASSDCLE-TVRPPSMQQCE 1069
GQ+ R V+C+ G + +C +PPS + C+
Sbjct: 801 RGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACD 837
Score = 148 bits (374), Expect = 2e-35
Identities = 87/280 (31%), Positives = 136/280 (48%), Gaps = 21/280 (7%)
Query: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGD 907
PWS+CS C G + ++V C + + + + +PP + AC+ PC WF D
Sbjct: 791 PWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSRE-ACDMGPCTTAWFHSD 849
Query: 908 WL-ECSKTCDGGMRTRAVLCIRK---IGPSEEETLDYSG--CLT-HRPVEKEPCNNQSCP 960
W +CS C G++ R+V+C+ +GP + E +G C T RP + C+ C
Sbjct: 850 WSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCE 909
Query: 961 P--QWVALDWSECTPKCGPGFKHRIVLCKS---SDLSKTFPAAQCPEESKPPVRIRCSLG 1015
+W W EC+ +CG G + R ++C S ++ + T P+ C +PP C G
Sbjct: 910 RTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPS-NCSHLPRPPALQPCQ-G 967
Query: 1016 RCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESK-CDS 1074
+ RW + W CS C G Q R VQCLS S+ C +RP + C S+ C
Sbjct: 968 QACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
Query: 1075 TPISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
P ++CKD + +CPLV++ + C Y+ CC++C
Sbjct: 1028 RP---DDQCKDSS--PHCPLVVQARLCVYPYYTATCCRSC 1062
Score = 122 bits (307), Expect = 1e-27
Identities = 72/245 (29%), Positives = 105/245 (42%), Gaps = 14/245 (5%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
W S CSA+C GV R +C + + C ++PP + C+ PCPP W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
G+W CS++C G + R + C ++ G RP + C + C
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
Query: 964 VALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
V WS+C+ +CG G + R V C ++ + +PP R C +G C W
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC-TTAWF 846
Query: 1024 TGDW-GQCSAQCGLGQQMRTVQCLSY-------TGQASS----DCLETVRPPSMQQCE-S 1070
DW +CSA+CG G Q R+V CL G+A + C RPP M+ C
Sbjct: 847 HSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLG 906
Query: 1071 KCDST 1075
C+ T
Sbjct: 907 PCERT 911
Score = 83.2 bits (204), Expect = 1e-15
Identities = 43/126 (34%), Positives = 61/126 (48%), Gaps = 8/126 (6%)
Query: 836 GDNEVGFTWNHQPWSECSATCAGGVQRQEVVC--KRLDDNSIVQNNYCDPDSKPPENQRA 893
G E + W PW ECS+ C G QR++++C K + ++ + C +PP Q
Sbjct: 906 GPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQ-P 964
Query: 894 CNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEP 953
C + C WF W CS++C GG +TR V C+ S +TL RP K P
Sbjct: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCL-----STNQTLSTRCPPQLRPSRKRP 1019
Query: 954 CNNQSC 959
CN+Q C
Sbjct: 1020 CNSQPC 1025
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/34 (47%), Positives = 18/34 (52%)
Query: 555 QSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSP 588
Q +G WGPW W CS+ CG GV R C P
Sbjct: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 270 bits (690), Expect = 6e-72
Identities = 183/577 (31%), Positives = 253/577 (43%), Gaps = 73/577 (12%)
Query: 523 SIPAAEGTLCQ----TGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGV 578
S+P G Q TG G + D G W + G SLW
Sbjct: 304 SVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLW----------- 352
Query: 579 SSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYN 638
SL SP P C GE ++ R+C+ PCP D R QCA F++ F G+ Y
Sbjct: 353 --SLFAPSSPIPR-----CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQ 405
Query: 639 WKPYTG-GGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNIL 697
W+P+T G + C LNC G+ FY V DGT C + DIC+ G C GCD IL
Sbjct: 406 WEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGIL 465
Query: 698 GSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYI 757
GS R D C VCGGD STC + G D GY +++ IP G++ +++ ++ S NY+
Sbjct: 466 GSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYL 525
Query: 758 ALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEP---ESLEALGPTSENLIVMVL 814
AL+ G ING W +D P + GT F Y RP E ESL A GPT++ + V ++
Sbjct: 526 ALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMI 585
Query: 815 LQEQNLGIRYKFNV----PITRTGSGDNEVGFTWNHQPW----------SECSATCAGGV 860
QE+N G+ Y++ + PI + + V QP + A G +
Sbjct: 586 FQEENPGVFYQYVISSPPPILENPTPEPPVP---QLQPEILRVEPPLAPAPRPARTPGTL 642
Query: 861 QRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMR 920
QRQ + P P + R P W CS +C G+
Sbjct: 643 QRQVRI----------------PQMPAPPHPRTPLGSPA-AYWKRVGHSACSASCGKGVW 685
Query: 921 TRAVLCIRKIGPSEEETLDYSGCL--THRPVEKEPCNNQSCPPQWVALDWSECTPKCGPG 978
LCI + E LD C P EPC+ CPP W A +W+ C+ CGPG
Sbjct: 686 RPIFLCISR---ESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPG 742
Query: 979 FKHRIVLCKS--SDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGD-WGQCSAQCG 1035
+HR + C+ + P +C +P + C L C W G W QCS +CG
Sbjct: 743 TQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC--GHWEVGSPWSQCSVRCG 800
Query: 1036 LGQQMRTVQCLSYTGQ--ASSDCLE-TVRPPSMQQCE 1069
GQ+ R V+C+ G + +C +PPS + C+
Sbjct: 801 RGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACD 837
Score = 98.6 bits (244), Expect = 3e-20
Identities = 51/184 (27%), Positives = 77/184 (41%), Gaps = 1/184 (0%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
W S CSA+C GV R +C + + C ++PP + C+ PCPP W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
G+W CS++C G + R + C ++ G RP + C + C
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
Query: 964 VALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
V WS+C+ +CG G + R V C ++ + +PP R C +G C W
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC-TTAWF 846
Query: 1024 TGDW 1027
DW
Sbjct: 847 HSDW 850
Score = 60.5 bits (145), Expect = 9e-09
Identities = 38/129 (29%), Positives = 54/129 (41%), Gaps = 7/129 (5%)
Query: 844 WNHQPWSECSATCAGGVQRQEVVCKRL--DDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901
W W+ CS +C G Q +++ C++ S V C +P Q +C C
Sbjct: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ-SCQLRLCG- 784
Query: 902 EWFIGD-WLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP 960
W +G W +CS C G R+R V C+ G E SG +P +E C+ C
Sbjct: 785 HWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASG--PPQPPSREACDMGPCT 842
Query: 961 PQWVALDWS 969
W DWS
Sbjct: 843 TAWFHSDWS 851
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/34 (47%), Positives = 18/34 (52%)
Query: 555 QSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSP 588
Q +G WGPW W CS+ CG GV R C P
Sbjct: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 249 bits (637), Expect = 8e-66
Identities = 167/546 (30%), Positives = 264/546 (48%), Gaps = 64/546 (11%)
Query: 44 LTIPIRVDQNGAFLSFTVK--NDKHSRRRRSMDPI--------DPQQAVSKLFFKLSAYG 93
L +P+R D G +S V + R R P+ + ++ S LF+ ++ +G
Sbjct: 58 LAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFG 117
Query: 94 KHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVG 153
+ HL L N V+ T+E+ G+ G L +C Y G + + VALSNC G
Sbjct: 118 RDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDG 177
Query: 154 LHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFT 213
L G+I E+EE+FIEPL+ + E G HV+Y++ G
Sbjct: 178 LAGLIRMEEEEFFIEPLEKGLAAQEA---EQGRVHVVYRRPPTSPP-------LGGPQAL 227
Query: 214 RSGKPWWLNDTSTVSYSLPINNTHIHHRQKRS----VSIERFVETLVVADKMMVGYHGRK 269
+G L+ ++S +L + H + ++R+ + +E L+ D +V +HG++
Sbjct: 228 DTGAS--LDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKE 285
Query: 270 DIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLT--EDQPNLEINHHADKSLDSFCK 327
++ Y+L++MNIV ++Y D SLG +N+++ R+I+L+ + +EI + + +SL++ C+
Sbjct: 286 HVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPS-QSLENVCR 344
Query: 328 W----QKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEP 383
W QK H +HD+A+ +TR D P G G A V GMC P
Sbjct: 345 WAYLQQKPDTGHDE-----------YHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHP 388
Query: 384 ERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFS 443
RSC++N + G SAF +AHE GH GM HDG GN CG + +MA + A + F
Sbjct: 389 VRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE-VRLGSIMAPLVQAAFHRFH 447
Query: 444 WSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQC-- 501
WS CS+ ++ +L S CL ++P D+ PG Y +EQCRF +G C
Sbjct: 448 WSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTA 505
Query: 502 -KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSID 558
+ + C++LWC N C T P +GT+C G G V +P ++
Sbjct: 506 FRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKFRPG------AVAHACYPSTL- 558
Query: 559 GGWGPW 564
GG G W
Sbjct: 559 GGQGRW 564
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,288,357
Number of Sequences: 37866
Number of extensions: 2584854
Number of successful extensions: 7229
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 70
Number of HSP's that attempted gapping in prelim test: 5158
Number of HSP's gapped (non-prelim): 823
length of query: 1117
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1004
effective length of database: 13,968,660
effective search space: 14024534640
effective search space used: 14024534640
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.