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Search of human proteins with 62460637
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62460637 importin 4 [Homo sapiens]
(1081 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62460637 importin 4 [Homo sapiens] 2110 0.0
gi|24797086 importin 5 [Homo sapiens] 167 4e-41
gi|45331213 RAN binding protein 6 [Homo sapiens] 151 4e-36
gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens] 72 3e-12
gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens] 69 3e-11
gi|23510381 transportin 1 isoform 2 [Homo sapiens] 67 1e-10
gi|133925811 transportin 1 isoform 1 [Homo sapiens] 67 1e-10
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso... 66 2e-10
gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso... 66 2e-10
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof... 66 2e-10
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ... 47 1e-04
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 45 3e-04
gi|21361794 TIP120 protein [Homo sapiens] 43 0.001
gi|153791502 transmembrane and coiled-coil domains 7 [Homo sapiens] 43 0.002
gi|122937211 KIAA0368 protein [Homo sapiens] 39 0.027
gi|19923142 karyopherin beta 1 [Homo sapiens] 39 0.035
gi|224831257 importin 13 [Homo sapiens] 38 0.045
gi|57863301 CLIP-associating protein 2 [Homo sapiens] 38 0.059
gi|115529449 upstream binding transcription factor, RNA polymera... 38 0.059
gi|115529451 upstream binding transcription factor, RNA polymera... 38 0.059
gi|7657671 upstream binding transcription factor, RNA polymerase... 38 0.059
gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo sap... 37 0.077
gi|18087817 coiled-coil domain containing 34 isoform 2 [Homo sap... 37 0.077
gi|4505999 protein phosphatase 1G [Homo sapiens] 37 0.13
gi|29826282 protein phosphatase 1G [Homo sapiens] 37 0.13
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 36 0.17
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 36 0.17
gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil... 36 0.22
gi|21361659 importin 9 [Homo sapiens] 36 0.22
gi|119709834 castor homolog 1, zinc finger isoform a [Homo sapiens] 35 0.29
>gi|62460637 importin 4 [Homo sapiens]
Length = 1081
Score = 2110 bits (5466), Expect = 0.0
Identities = 1081/1081 (100%), Positives = 1081/1081 (100%)
Query: 1 MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVL 60
MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVL
Sbjct: 1 MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVL 60
Query: 61 TRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLL 120
TRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLL
Sbjct: 61 TRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLL 120
Query: 121 QLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYS 180
QLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYS
Sbjct: 121 QLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYS 180
Query: 181 LRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVIT 240
LRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVIT
Sbjct: 181 LRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVIT 240
Query: 241 PYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVA 300
PYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVA
Sbjct: 241 PYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVA 300
Query: 301 AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA 360
AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA
Sbjct: 301 AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA 360
Query: 361 LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ 420
LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ
Sbjct: 361 LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ 420
Query: 421 FSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPEL 480
FSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPEL
Sbjct: 421 FSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPEL 480
Query: 481 MECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPV 540
MECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPV
Sbjct: 481 MECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPV 540
Query: 541 QIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEG 600
QIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEG
Sbjct: 541 QIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEG 600
Query: 601 LAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEI 660
LAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEI
Sbjct: 601 LAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEI 660
Query: 661 SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEA 720
SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEA
Sbjct: 661 SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEA 720
Query: 721 LGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLR 780
LGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLR
Sbjct: 721 LGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLR 780
Query: 781 SCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP 840
SCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP
Sbjct: 781 SCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP 840
Query: 841 ALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRL 900
ALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRL
Sbjct: 841 ALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRL 900
Query: 901 LPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDN 960
LPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDN
Sbjct: 901 LPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDN 960
Query: 961 ICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVA 1020
ICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVA
Sbjct: 961 ICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVA 1020
Query: 1021 PELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGL 1080
PELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGL
Sbjct: 1021 PELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGL 1080
Query: 1081 S 1081
S
Sbjct: 1081 S 1081
>gi|24797086 importin 5 [Homo sapiens]
Length = 1115
Score = 167 bits (424), Expect = 4e-41
Identities = 238/1055 (22%), Positives = 445/1055 (42%), Gaps = 101/1055 (9%)
Query: 1 MESAGLEQ-----LLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQ 55
M +A EQ LL LL PD ++A E + + L + + A + RQ
Sbjct: 19 MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQ 78
Query: 56 FAAVLTRRRLNTRWRR----LAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFR-- 109
AAVL RR L++ + L ++ + ++KS +L +Q ET+ + + ++A + R
Sbjct: 79 MAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNL 138
Query: 110 --KEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAF---QPHHRELL-RL 163
++G WP+ L+ L S S + RE L + + P F Q H+ +++ R+
Sbjct: 139 IDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIF----WNFPGIFGNQQQHYLDVIKRM 194
Query: 164 LNETLGEVGSPGLLFYSLRTLTTMAPYLSTE-DVPLARMLVPKLIMAMQTLIPIDEAKAC 222
L + + + P + S R T A L+ E +V L + L +Q +
Sbjct: 195 LVQCMQDQEHPSIRTLSARA--TAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDD 252
Query: 223 EALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKAL 282
L++L E+ ++ + P+L L L++ + +L N R L + L + + L
Sbjct: 253 SVLKSLVEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAML 312
Query: 283 LKN-----RLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVV 337
K+ + +P +L + + E + ED D + + E +
Sbjct: 313 RKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGE-----------SAL 361
Query: 338 DMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQ 397
D +A L + + P + + + L++ R AGL+ L+ + +G + + +L ++
Sbjct: 362 DRMACGLGGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQM-EGILNEIVN 420
Query: 398 IVCKGLEDPSQVVRNAALFALGQFSENLQPHISS-YSREVMPLLLAYLKSVPLGHTHHLA 456
V L+DP VR AA A+GQ + + P + +V+ LL ++ G+ A
Sbjct: 421 FVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQ--GNQRVQA 478
Query: 457 KACYALENFVENLGPK--VQPYLPELMECM-------LQLLRNPSSPRAKELAVSALGAI 507
A AL NF E+ PK + PYL L++ + LQ L + E V+++ ++
Sbjct: 479 HAAAALINFTEDC-PKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASV 537
Query: 508 ATAAQASLLPYFPAIMEHLREFLLTG-REDLQPVQIQSLETLGVLARAVG-EPMRPLAEE 565
A A+ +PY+ M L+ + +++L+ ++ +++E + ++ AVG E A +
Sbjct: 538 ADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD 597
Query: 566 CCQLGL----GLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEG 621
QL L D DD S +A + ++G+ +Q +++ L T
Sbjct: 598 VMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGK----EFQQYLPVVMGPLMKTAS 653
Query: 622 IVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDD-SEISGYSVENAFFDEKEDTCAAV 680
I P+ LL D ++ E + D+D E + + + ++ A +EK C +
Sbjct: 654 IKPEVA-----LL-----DTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQML 703
Query: 681 GEISVNTSVAFLPYMESVFEEVFKLLECP-HLNVRKAAHEALGQFCCALHKACQSCPSEP 739
+ F+ Y E V + + LL+ H VR AA E++ C
Sbjct: 704 VCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVAAAESMPLLL--------ECARVR 755
Query: 740 NTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGV 799
L + + ++A+ E + V+ ++ + + G L EL G+
Sbjct: 756 GPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNE-HFEELGGI 814
Query: 800 LKAVLQR----------KTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGD 849
LKA L+ K +D DE+ EE D+ + D +L + + ++ ++ +
Sbjct: 815 LKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYK-E 873
Query: 850 SFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQ 909
P+F LPL+V ++ + + + I+ AS ++ L +L
Sbjct: 874 KVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVC 933
Query: 910 EADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLL-----ARERHDRVRDNICGA 964
+ PEVR A +G+GV+A++GG + + L LL ++ + + +N A
Sbjct: 934 DNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENCISA 993
Query: 965 LARLLMASPTRKPEPQVLAALLHALPLKEDLEEWV 999
+ +++ P +VL L LPL ED EE V
Sbjct: 994 VGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAV 1028
>gi|45331213 RAN binding protein 6 [Homo sapiens]
Length = 1105
Score = 151 bits (381), Expect = 4e-36
Identities = 240/1083 (22%), Positives = 441/1083 (40%), Gaps = 102/1083 (9%)
Query: 8 QLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASA-ADPQIRQFAAVLTRRRLN 66
QLL+ L+ P +RR E++ + L D + + A ++RQ AA L RR L+
Sbjct: 21 QLLKNLINPSC-MVRRQAEEIYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAALLRRLLS 79
Query: 67 TRWRR----LAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFR----KEGLEAWPQ 118
+ + L A+ + +K ++ A++ ET + L + A + R ++G WP+
Sbjct: 80 SGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDEDGTNHWPE 139
Query: 119 LLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELL----RLLNETLGEVGSP 174
L+ L S +S + E+ L V P F R L RLL++ + + P
Sbjct: 140 GLKFLIDSIYSKNVVLWEVALH----VFWHFPGIFGTQERHDLDIIKRLLDQCIQDQEHP 195
Query: 175 GLLFYSLRTLTTMAPYLSTEDVPLARM---LVPKLIMAMQTLIPIDEAKACEALEALDEL 231
+ S R + ++ L + L+P ++ A+ D+ LE+L E+
Sbjct: 196 AIRTLSARAAAAFV-LANENNIALFKDFADLLPGILQAVNDSCYQDDDSV---LESLVEI 251
Query: 232 LESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLK--NRLLP 289
++ + PYL + L L++ + L N R L + L + + L K N +
Sbjct: 252 ADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVIVTLSETATPMLKKHTNIIAQ 311
Query: 290 PLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKL 349
+ H L +V + ++ ++ EE++ + + A +D LA L + +
Sbjct: 312 AVPHILAMMVDLQDDEDWVNADEM--EEDDFDSNAVA------AESALDRLACGLGGKVV 363
Query: 350 CPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQV 409
P + + L+S R AGL+ L+ + +G + + +L + V L+DP
Sbjct: 364 LPMTKEHIMQMLQSPDWKYRHAGLMALSAIGEGCHQQM-ESILDETVNSVLLFLQDPHPR 422
Query: 410 VRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVP-LGHTHHLAKACYALENFVEN 468
VR AA LGQ + + P+ E + + A L+++ G+ + A AL F+E+
Sbjct: 423 VRAAACTTLGQMATDFAPNFQKKFHETV--IAALLRTMENQGNQRVQSHAASALIIFIED 480
Query: 469 LGPK---------VQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYF 519
PK + L ++ LQ L + A E V+ + ++A + +PY+
Sbjct: 481 C-PKSLLVLYVDSMVKNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKFVPYY 539
Query: 520 PAIMEHLREFL-LTGREDLQPVQIQSLETLGVLARAVG-EPMRPLAEECCQLGL----GL 573
M L+ + L +++L+ ++ +++E + + AVG E A QL L L
Sbjct: 540 DIFMPSLKHIVELAVQKELKLLRGKTIECISHIGLAVGKEKFMQDASNVMQLLLKTQSDL 599
Query: 574 CDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFL 633
+ DD S +A + ++G+ +L + L+ S + V D
Sbjct: 600 NNMEDDDPQTSYMVSAWARMCKILGKDFQQYLPLVIE-PLIKTASAKPDVALLDTQDVEN 658
Query: 634 LFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFLP 693
+ DD DG + L D+ + ++ + + K C + + F+
Sbjct: 659 MSDD--DGWQFVNLGDQQ----------SFGIKTSGLEAKATACQMLVYYAKELREGFVE 706
Query: 694 YMESVFEEVFKLLECP-HLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAALARVV 752
Y E V + + LL+ H NVR AA E++ C L +
Sbjct: 707 YTEQVVKLMVPLLKFYFHDNVRVAAAESMPFLL--------ECARIRGPEYLAQMWQFIC 758
Query: 753 PSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVL-------- 804
++A+ E + V+ ++ + + G L L EL G+LKA L
Sbjct: 759 DPLIKAIGTEPDTDVLSEIMNSFAKSIEVMGDGCLNDE-HLEELGGILKAKLEGHFKNQE 817
Query: 805 --QRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFAGFLPLL 862
Q K ++ D++ E D+ E D +L + + +L + + P+F LPL+
Sbjct: 818 LRQVKRQEENYDQQVEMSLQDEDECDVYILTKVSDILHSLFSTYK-EKILPWFEQLLPLI 876
Query: 863 VCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFG 922
V ++ + + + I+ S ++V +L ++ +PEVR A +G
Sbjct: 877 VNLICSSRPWPDRQWGLCIFDDIIEHCSPTSFKYVEYFRWPMLLNMRDNNPEVRQAAAYG 936
Query: 923 MGVLAEHGGHPAQEHFPKLLGLLFPLLAR---------ERHDRVRDNICGALARLLMASP 973
+GV+A+ GG + + L PLL + +++ +N A+ ++L P
Sbjct: 937 LGVMAQFGG----DDYRSLCSEAVPLLVKVIKCANSKTKKNVIATENCISAIGKILKFKP 992
Query: 974 TRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLRICSLILAD 1033
+VL L LPL ED EE + L +S+ VI L I+A+
Sbjct: 993 NCVNVDEVLPHWLSWLPLHEDKEEAIQTLSFLCDLIESNHPVVIGPNNSNLPKIISIIAE 1052
Query: 1034 NKI 1036
KI
Sbjct: 1053 GKI 1055
>gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens]
Length = 1236
Score = 72.0 bits (175), Expect = 3e-12
Identities = 159/695 (22%), Positives = 258/695 (37%), Gaps = 136/695 (19%)
Query: 358 EEALRSESPYQRKAGLLVLAVLSDGAGD--------------HIRQRLLPPLLQIVCKGL 403
+++++ + +RK ++L +L D G+ +++ + ++ +C +
Sbjct: 36 KDSIQLDEDSERKVVKMLLRLLEDKNGEVQNLAVKCLGPLVVKVKEYQVETIVDTLCTNM 95
Query: 404 EDPSQVVRNAALFALGQFSENLQPHI--SSYSREVMPLLLAYLKSVPLGHTHHLAKACYA 461
+ +R+ A L L P S + V + L S + +A A
Sbjct: 96 RSDKEQLRDIAGIGLKTVLSELPPAATGSGLATNVCRKITGQLTSA-IAQQEDVAVQLEA 154
Query: 462 LE---NFVENLGPKVQPYLPELMECMLQLLRNPSSPR--AKELAVSALGAIATAAQASLL 516
L+ + + LG + + L+ C+L L SSPR ++ AV ALG +A A L
Sbjct: 155 LDILSDMLSRLGVPLGAFHASLLHCLLPQL---SSPRLAVRKRAVGALGHLAAACSTDL- 210
Query: 517 PYFPAIMEHLREFLLTGREDLQPVQIQSL-ETLGVLARAVG-------EPMRPLAEECCQ 568
F + +HL + L R P I++L + LG + R G + + PL E+ C
Sbjct: 211 --FVELADHLLDRLPGPRVPTSPTAIRTLIQCLGSVGRQAGHRLGAHLDRLVPLVEDFCN 268
Query: 569 LGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDG 628
L DD +LR F A + + PH+ +T+L L ++ P Y+
Sbjct: 269 L--------DDDELRESCLQAFEAFLRKCPKEMGPHVPNVTSLCLQYIKHD----PNYN- 315
Query: 629 SSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTS 688
D +E+EE M E +DSE S E+ + D+ +D V +
Sbjct: 316 ----------YDSDEDEEQM-----ETEDSEFSEQESEDEYSDD-DDMSWKVRRAAAKCI 359
Query: 689 VAFLPYMESVFEEVFKLLECPHLNVRKAAHE---ALGQFCCALHKACQSCP--------S 737
A + + + F P L R E F + Q+ P
Sbjct: 360 AALISSRPDLLPD-FHCTLAPVLIRRFKEREENVKADVFTAYIVLLRQTQPPKGWLEAME 418
Query: 738 EPNTAALQAALAR-VVPSYMQAVNRE------RERQVVMAVLEALTGVLRSCGTLTLKPP 790
EP + R VP ++A+ R+ R RQ ++L L GVL P
Sbjct: 419 EPTQTGSNLHMLRGQVPLVVKALQRQLKDRSVRARQGCFSLLTELAGVL----------P 468
Query: 791 GRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDS 850
G LAE VL + + A + DA+ + L ++
Sbjct: 469 GSLAEHMPVLVSGIIFSLA--------DRSSSSTIRMDALAF------LQGLLGTEPAEA 514
Query: 851 FAPFFAGFL-PLLVCKTKQGCTVAEKSFAVGTLAETIQGL---------------GAASA 894
F P L P++ C +A ++ V L E ++ L G SA
Sbjct: 515 FHPHLPILLPPVMACVADSFYKIAAEALVV--LQELVRALWPLHRPRMLDPEPYVGEMSA 572
Query: 895 QFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERH 954
++RL A + D EV+ AI MG L H G + L L LL R R+
Sbjct: 573 VTLARL------RATDLDQEVKERAISCMGHLVGHLGDRLGDDLEPTLLL---LLDRLRN 623
Query: 955 DRVRDNICGALARLLMASPTRKPEPQVLAALLHAL 989
+ R AL L+ SP + +LA LH L
Sbjct: 624 EITRLPAIKALT-LVAVSPLQLDLQPILAEALHIL 657
Score = 34.3 bits (77), Expect = 0.65
Identities = 58/253 (22%), Positives = 99/253 (39%), Gaps = 28/253 (11%)
Query: 384 GDHIRQRLLPPLLQIVCKGLEDPSQV--VRNAALFALGQFSENLQPHISSYSREVMPLLL 441
GD + L P LL ++ + + +++ ++ L A+ +LQP ++ E + +L
Sbjct: 603 GDRLGDDLEPTLLLLLDRLRNEITRLPAIKALTLVAVSPLQLDLQPILA----EALHILA 658
Query: 442 AYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAV 501
++L+ LA AL+ ++ G + P + + L L N S +LAV
Sbjct: 659 SFLRKNQ--RALRLATLA-ALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAV 715
Query: 502 SALGAIATAAQASLLPYFPAIMEHLREFL---------LTGREDLQPVQIQSLETLGVLA 552
L + A ASL+ ++ L L L E + + A
Sbjct: 716 DFLATVTQAQPASLVEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYA 775
Query: 553 RAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAA--------LSGLMGEGLAPH 604
+ + P+ E+ G GL QV L RC +L AA S L+ + +PH
Sbjct: 776 KLISLLTAPVYEQAVDGGPGLHKQVFH-SLARCVAALSAACPQEAASTASRLVCDARSPH 834
Query: 605 LEQ-ITTLMLLSL 616
+ L LSL
Sbjct: 835 SSTGVKVLAFLSL 847
Score = 33.5 bits (75), Expect = 1.1
Identities = 61/253 (24%), Positives = 98/253 (38%), Gaps = 44/253 (17%)
Query: 350 CPQLMPMLEEAL--RSESPYQRKAGLLVLAVLS-----DGAGDHIRQRLLPPLLQIVCKG 402
CPQ L + SP+ G+ VLA LS AG ++ L LL+
Sbjct: 815 CPQEAASTASRLVCDARSPHS-STGVKVLAFLSLAEVGQVAGPGHQRELKAVLLE----A 869
Query: 403 LEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGH---THHLAKAC 459
L PS+ VR AA +ALG+ P + +P LL +++ P H L +A
Sbjct: 870 LGSPSEDVRAAASYALGRVGAGSLP-------DFLPFLLEQIEAEPRRQYLLLHSLREAL 922
Query: 460 YALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYF 519
A + ++PY ++ + Q + + + +G + + LLP
Sbjct: 923 GAAQ------PDSLKPYAEDIWALLFQRCEG-AEEGTRGVVAECIGKLVLVNPSFLLP-- 973
Query: 520 PAIMEHLREFLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDD 579
LR+ L GR + I +++ L P+ PL + + + D
Sbjct: 974 -----RLRKQLAAGRPHTRSTVITAVK---FLISDQPHPIDPLLKSFIG---EFMESLQD 1022
Query: 580 PDL--RRCTYSLF 590
PDL RR T + F
Sbjct: 1023 PDLNVRRATLAFF 1035
>gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]
Length = 1119
Score = 68.6 bits (166), Expect = 3e-11
Identities = 149/600 (24%), Positives = 225/600 (37%), Gaps = 126/600 (21%)
Query: 434 REVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSS 493
R+V+ +LL L+ G +LA V+ LG + + L+ C+L L SS
Sbjct: 47 RKVVKMLLRLLEDKN-GEVQNLA---------VKWLGVPLGAFHASLLHCLLPQL---SS 93
Query: 494 PR--AKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPVQIQSL-ETLGV 550
PR ++ AV ALG +A A L F + +HL + L R P I++L + LG
Sbjct: 94 PRLAVRKRAVGALGHLAAACSTDL---FVELADHLLDRLPGPRVPTSPTAIRTLIQCLGS 150
Query: 551 LARAVG-------EPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAP 603
+ R G + + PL E+ C L DD +LR F A + + P
Sbjct: 151 VGRQAGHRLGAHLDRLVPLVEDFCNL--------DDDELRESCLQAFEAFLRKCPKEMGP 202
Query: 604 HLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGY 663
H+ +T+L L ++ P Y+ D +E+EE M E +DSE S
Sbjct: 203 HVPNVTSLCLQYIKHD----PNYN-----------YDSDEDEEQM-----ETEDSEFSEQ 242
Query: 664 SVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHE---A 720
E+ + D+ +D V + A + + + F P L R E
Sbjct: 243 ESEDEYSDD-DDMSWKVRRAAAKCIAALISSRPDLLPD-FHCTLAPVLIRRFKEREENVK 300
Query: 721 LGQFCCALHKACQSCP--------SEPNTAALQAALAR-VVPSYMQAVNRE------RER 765
F + Q+ P EP + R VP ++A+ R+ R R
Sbjct: 301 ADVFTAYIVLLRQTQPPKGWLEAMEEPTQTGSNLHMLRGQVPLVVKALQRQLKDRSVRAR 360
Query: 766 QVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQA 825
Q ++L L GVL PG LAE VL + + A +
Sbjct: 361 QGCFSLLTELAGVL----------PGSLAEHMPVLVSGIIFSLA--------DRSSSSTI 402
Query: 826 EYDAMLLEHAGEAIPALAAAAGGDSFAPFFAGFL-PLLVCKTKQGCTVAEKSFAVGTLAE 884
DA+ + L ++F P L P++ C +A ++ V L E
Sbjct: 403 RMDALAF------LQGLLGTEPAEAFHPHLPILLPPVMACVADSFYKIAAEALVV--LQE 454
Query: 885 TIQGL---------------GAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEH 929
++ L G SA ++RL A + D EV+ AI MG L H
Sbjct: 455 LVRALWPLHRPRMLDPEPYVGEMSAVTLARL------RATDLDQEVKERAISCMGHLVGH 508
Query: 930 GGHPAQEHFPKLLGLLFPLLARERHDRVRDNICGALARLLMASPTRKPEPQVLAALLHAL 989
G + L L LL R R++ R AL L+ SP + +LA LH L
Sbjct: 509 LGDRLGDDLEPTLLL---LLDRLRNEITRLPAIKALT-LVAVSPLQLDLQPILAEALHIL 564
Score = 34.3 bits (77), Expect = 0.65
Identities = 58/253 (22%), Positives = 99/253 (39%), Gaps = 28/253 (11%)
Query: 384 GDHIRQRLLPPLLQIVCKGLEDPSQV--VRNAALFALGQFSENLQPHISSYSREVMPLLL 441
GD + L P LL ++ + + +++ ++ L A+ +LQP ++ E + +L
Sbjct: 510 GDRLGDDLEPTLLLLLDRLRNEITRLPAIKALTLVAVSPLQLDLQPILA----EALHILA 565
Query: 442 AYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAV 501
++L+ LA AL+ ++ G + P + + L L N S +LAV
Sbjct: 566 SFLRKNQ--RALRLATLA-ALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAV 622
Query: 502 SALGAIATAAQASLLPYFPAIMEHLREFL---------LTGREDLQPVQIQSLETLGVLA 552
L + A ASL+ ++ L L L E + + A
Sbjct: 623 DFLATVTQAQPASLVEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYA 682
Query: 553 RAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAA--------LSGLMGEGLAPH 604
+ + P+ E+ G GL QV L RC +L AA S L+ + +PH
Sbjct: 683 KLISLLTAPVYEQAVDGGPGLHKQVFH-SLARCVAALSAACPQEAASTASRLVCDARSPH 741
Query: 605 LEQ-ITTLMLLSL 616
+ L LSL
Sbjct: 742 SSTGVKVLAFLSL 754
Score = 30.4 bits (67), Expect = 9.4
Identities = 50/209 (23%), Positives = 82/209 (39%), Gaps = 36/209 (17%)
Query: 350 CPQLMPMLEEAL--RSESPYQRKAGLLVLAVLS-----DGAGDHIRQRLLPPLLQIVCKG 402
CPQ L + SP+ G+ VLA LS AG ++ L LL+
Sbjct: 722 CPQEAASTASRLVCDARSPHS-STGVKVLAFLSLAEVGQVAGPGHQRELKAVLLE----A 776
Query: 403 LEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGH---THHLAKAC 459
L PS+ VR AA +ALG+ P + +P LL +++ P H L +A
Sbjct: 777 LGSPSEDVRAAASYALGRVGAGSLP-------DFLPFLLEQIEAEPRRQYLLLHSLREAL 829
Query: 460 YALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYF 519
A + ++PY ++ + Q + + + +G + + LLP
Sbjct: 830 GAAQ------PDSLKPYAEDIWALLFQRCEG-AEEGTRGVVAECIGKLVLVNPSFLLP-- 880
Query: 520 PAIMEHLREFLLTGREDLQPVQIQSLETL 548
LR+ L GR + I +++ L
Sbjct: 881 -----RLRKQLAAGRPHTRSTVITAVKFL 904
>gi|23510381 transportin 1 isoform 2 [Homo sapiens]
Length = 890
Score = 66.6 bits (161), Expect = 1e-10
Identities = 98/438 (22%), Positives = 185/438 (42%), Gaps = 46/438 (10%)
Query: 299 VAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLE 358
VA + ++ ED D +E + + + + + +D+LA ++ ++L P ++P+L+
Sbjct: 345 VAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLA-NVYRDELLPHILPLLK 403
Query: 359 EALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFAL 418
E L +++G+LVL +++G + LP L+ + + L D +VR+ + L
Sbjct: 404 ELLFHHEWVVKESGILVLGAIAEGCMQGMIP-YLPELIPHLIQCLSDKKALVRSITCWTL 462
Query: 419 GQFSENL--QPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPY 476
+++ + QP + PL+ LK + + AC A E ++ PY
Sbjct: 463 SRYAHWVVSQPP----DTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 518
Query: 477 LPELMECMLQLLRNPSSPRAKELAV--SALGAIATAAQASL--LPYFPAIMEHLRE---F 529
L +++ ++ S + K L + A+G +A + L Y +M L +
Sbjct: 519 LAYILDTLVFAF---SKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNM 575
Query: 530 LLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC--------------D 575
L +DL P+ LE L +A A+ P E Q + L D
Sbjct: 576 LKDEDKDLFPL----LECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPD 631
Query: 576 QVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQI---TTLMLLSLRSTEGIVPQYDGSSSF 632
Q + PD +L LSGL EGL ++EQ+ + ++ L + + +P+ SS
Sbjct: 632 QYEAPDKDFMIVAL-DLLSGL-AEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFA 689
Query: 633 LLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFL 692
LL D + + D I G ++ F + A+GEIS+ +
Sbjct: 690 LLGDLTKACFQHVKPCIADF-----MPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQ 744
Query: 693 PYMESVFEEVFKLLECPH 710
PY+ V ++ +++ P+
Sbjct: 745 PYIPMVLHQLVEIINRPN 762
Score = 48.9 bits (115), Expect = 3e-05
Identities = 90/446 (20%), Positives = 179/446 (40%), Gaps = 54/446 (12%)
Query: 97 SLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPH 156
S + + A ++R E L P +L LL+ +E G+L+L + + P+
Sbjct: 379 SAAALDVLANVYRDELL---PHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPY 435
Query: 157 HRELLRLLNETLGEVGSPGLLFYSLR--TLTTMAPYLSTE--DVPLARMLVPKLIMAMQT 212
EL+ L + L + + L S+ TL+ A ++ ++ D L ++ L + +
Sbjct: 436 LPELIPHLIQCLSDKKA---LVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDS 492
Query: 213 LIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLT 272
+ EA AC A L+E +E+ Y+ + L F ++ L + + +
Sbjct: 493 NKRVQEA-ACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNL-----LILYDAIG 546
Query: 273 FLVKVKSKALLK----NRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGET 328
L L K L+PPL+ L ED+D L+
Sbjct: 547 TLADSVGHHLNKPEYIQMLMPPLIQKW----------NMLKDEDKDL------FPLLECL 590
Query: 329 PKHFAVQVVDMLALHLPPEKLCPQLMP--MLEEALRSESPYQRKA--------GLLVLAV 378
L P + C L+ + + L + P Q +A L +L+
Sbjct: 591 SSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSG 650
Query: 379 LSDGAGDHIRQRLLPP-LLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVM 437
L++G G +I Q + +L ++ + ++D VR ++ LG ++ H+ + M
Sbjct: 651 LAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFM 710
Query: 438 PLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRA- 496
P+L L + ++ A +A+ +G ++QPY+P ++ +++++ P++P+
Sbjct: 711 PILGTNLNPEFISVCNN---ATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTL 767
Query: 497 ---KELAVSALGAIATAAQASLLPYF 519
+ + LG + A +L F
Sbjct: 768 LENTAITIGRLGYVCPQEVAPMLQQF 793
>gi|133925811 transportin 1 isoform 1 [Homo sapiens]
Length = 898
Score = 66.6 bits (161), Expect = 1e-10
Identities = 98/438 (22%), Positives = 185/438 (42%), Gaps = 46/438 (10%)
Query: 299 VAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLE 358
VA + ++ ED D +E + + + + + +D+LA ++ ++L P ++P+L+
Sbjct: 353 VAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLA-NVYRDELLPHILPLLK 411
Query: 359 EALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFAL 418
E L +++G+LVL +++G + LP L+ + + L D +VR+ + L
Sbjct: 412 ELLFHHEWVVKESGILVLGAIAEGCMQGMIP-YLPELIPHLIQCLSDKKALVRSITCWTL 470
Query: 419 GQFSENL--QPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPY 476
+++ + QP + PL+ LK + + AC A E ++ PY
Sbjct: 471 SRYAHWVVSQPP----DTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 526
Query: 477 LPELMECMLQLLRNPSSPRAKELAV--SALGAIATAAQASL--LPYFPAIMEHLRE---F 529
L +++ ++ S + K L + A+G +A + L Y +M L +
Sbjct: 527 LAYILDTLVFAF---SKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNM 583
Query: 530 LLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC--------------D 575
L +DL P+ LE L +A A+ P E Q + L D
Sbjct: 584 LKDEDKDLFPL----LECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPD 639
Query: 576 QVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQI---TTLMLLSLRSTEGIVPQYDGSSSF 632
Q + PD +L LSGL EGL ++EQ+ + ++ L + + +P+ SS
Sbjct: 640 QYEAPDKDFMIVAL-DLLSGL-AEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFA 697
Query: 633 LLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFL 692
LL D + + D I G ++ F + A+GEIS+ +
Sbjct: 698 LLGDLTKACFQHVKPCIADF-----MPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQ 752
Query: 693 PYMESVFEEVFKLLECPH 710
PY+ V ++ +++ P+
Sbjct: 753 PYIPMVLHQLVEIINRPN 770
Score = 48.9 bits (115), Expect = 3e-05
Identities = 90/446 (20%), Positives = 179/446 (40%), Gaps = 54/446 (12%)
Query: 97 SLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPH 156
S + + A ++R E L P +L LL+ +E G+L+L + + P+
Sbjct: 387 SAAALDVLANVYRDELL---PHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPY 443
Query: 157 HRELLRLLNETLGEVGSPGLLFYSLR--TLTTMAPYLSTE--DVPLARMLVPKLIMAMQT 212
EL+ L + L + + L S+ TL+ A ++ ++ D L ++ L + +
Sbjct: 444 LPELIPHLIQCLSDKKA---LVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDS 500
Query: 213 LIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLT 272
+ EA AC A L+E +E+ Y+ + L F ++ L + + +
Sbjct: 501 NKRVQEA-ACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNL-----LILYDAIG 554
Query: 273 FLVKVKSKALLK----NRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGET 328
L L K L+PPL+ L ED+D L+
Sbjct: 555 TLADSVGHHLNKPEYIQMLMPPLIQKW----------NMLKDEDKDL------FPLLECL 598
Query: 329 PKHFAVQVVDMLALHLPPEKLCPQLMP--MLEEALRSESPYQRKA--------GLLVLAV 378
L P + C L+ + + L + P Q +A L +L+
Sbjct: 599 SSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSG 658
Query: 379 LSDGAGDHIRQRLLPP-LLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVM 437
L++G G +I Q + +L ++ + ++D VR ++ LG ++ H+ + M
Sbjct: 659 LAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFM 718
Query: 438 PLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRA- 496
P+L L + ++ A +A+ +G ++QPY+P ++ +++++ P++P+
Sbjct: 719 PILGTNLNPEFISVCNN---ATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTL 775
Query: 497 ---KELAVSALGAIATAAQASLLPYF 519
+ + LG + A +L F
Sbjct: 776 LENTAITIGRLGYVCPQEVAPMLQQF 801
>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b)
isoform 1 [Homo sapiens]
Length = 897
Score = 66.2 bits (160), Expect = 2e-10
Identities = 102/438 (23%), Positives = 185/438 (42%), Gaps = 55/438 (12%)
Query: 301 AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA 360
AE P G D ED D ++ + L + + +D+LA ++ E+L P L+P+L+
Sbjct: 349 AERPDGSEDAEDDDDDDALSDWNL-----RKCSAAALDVLA-NVFREELLPHLLPLLKGL 402
Query: 361 LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ 420
L +++G+LVL +++G + LP L+ + + L D +VR+ A + L +
Sbjct: 403 LFHPEWVVKESGILVLGAIAEGCMQGMVP-YLPELIPHLIQCLSDKKALVRSIACWTLSR 461
Query: 421 FSENL--QPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLP 478
++ + QP + PL+ LK + G+ AC A E ++ PYL
Sbjct: 462 YAHWVVSQPP----DMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLS 517
Query: 479 ELMECMLQLLRNPSSPRAKELAV--SALGAIATAAQASL------LPYFPAIMEHLREFL 530
+++ ++ + K L + A+G +A + L P +++ E L
Sbjct: 518 YILDTLVFAF---GKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNE-L 573
Query: 531 LTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC--------------DQ 576
+DL P+ LE L +A A+ P E Q + L +Q
Sbjct: 574 KDEDKDLFPL----LECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQ 629
Query: 577 VDDPDLRRCTYSLFAALSGLMGEGLAPHLEQI---TTLMLLSLRSTEGIVPQYDGSSSFL 633
+ PD +L LSGL EGL H+EQ+ + +M L + + +P+ SS L
Sbjct: 630 YEAPDKDFMIVAL-DLLSGL-AEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFAL 687
Query: 634 LFD-DESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFL 692
L D ++ + + E + I G ++ F + A+GEI +
Sbjct: 688 LGDLTKACFIHVKPCIAEFMP------ILGTNLNPEFISVCNNATWAIGEICMQMGAEMQ 741
Query: 693 PYMESVFEEVFKLLECPH 710
PY++ V + +++ P+
Sbjct: 742 PYVQMVLNNLVEIINRPN 759
Score = 51.6 bits (122), Expect = 4e-06
Identities = 85/415 (20%), Positives = 177/415 (42%), Gaps = 44/415 (10%)
Query: 97 SLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPH 156
S + + A +FR+E L P LL LL+ P +E G+L+L + + P+
Sbjct: 376 SAAALDVLANVFREELL---PHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPY 432
Query: 157 HRELLRLLNETLGEVGSPGLLFYSLR--TLTTMAPYLSTE--DVPLARMLVPKLIMAMQT 212
EL+ L + L + + L S+ TL+ A ++ ++ D+ L ++ L +
Sbjct: 433 LPELIPHLIQCLSDKKA---LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDG 489
Query: 213 LIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLT 272
+ EA AC A L+E +E + PYLS +L + A G + + L L
Sbjct: 490 NKRVQEA-ACSAFATLEEEACTE---LVPYLSYILDTLV-----FAFGK-YQHKNLLILY 539
Query: 273 FLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHF 332
+ + ++ + P + L P L + + ++E+ ++ + E
Sbjct: 540 DAIGTLADSVGHHLNQPEYIQKLMP---------PLIQKWNELKDEDKDLFPLLECLSSV 590
Query: 333 AVQVVDMLALHLPP---------EKLCPQLMPMLEEALRSESPYQ--RKAGLLVLAVLSD 381
A + + P +K Q M + + E+P + L +L+ L++
Sbjct: 591 ATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAE 650
Query: 382 GAGDHIRQRLL-PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLL 440
G G H+ Q + ++ ++ + ++D VR ++ LG ++ H+ E MP+L
Sbjct: 651 GLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPIL 710
Query: 441 LAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPR 495
L + ++ A +A+ +G ++QPY+ ++ +++++ P++P+
Sbjct: 711 GTNLNPEFISVCNN---ATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPK 762
>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b)
isoform 3 [Homo sapiens]
Length = 887
Score = 66.2 bits (160), Expect = 2e-10
Identities = 102/438 (23%), Positives = 185/438 (42%), Gaps = 55/438 (12%)
Query: 301 AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA 360
AE P G D ED D ++ + L + + +D+LA ++ E+L P L+P+L+
Sbjct: 349 AERPDGSEDAEDDDDDDALSDWNL-----RKCSAAALDVLA-NVFREELLPHLLPLLKGL 402
Query: 361 LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ 420
L +++G+LVL +++G + LP L+ + + L D +VR+ A + L +
Sbjct: 403 LFHPEWVVKESGILVLGAIAEGCMQGMVP-YLPELIPHLIQCLSDKKALVRSIACWTLSR 461
Query: 421 FSENL--QPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLP 478
++ + QP + PL+ LK + G+ AC A E ++ PYL
Sbjct: 462 YAHWVVSQPP----DMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLS 517
Query: 479 ELMECMLQLLRNPSSPRAKELAV--SALGAIATAAQASL------LPYFPAIMEHLREFL 530
+++ ++ + K L + A+G +A + L P +++ E L
Sbjct: 518 YILDTLVFAF---GKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNE-L 573
Query: 531 LTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC--------------DQ 576
+DL P+ LE L +A A+ P E Q + L +Q
Sbjct: 574 KDEDKDLFPL----LECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQ 629
Query: 577 VDDPDLRRCTYSLFAALSGLMGEGLAPHLEQI---TTLMLLSLRSTEGIVPQYDGSSSFL 633
+ PD +L LSGL EGL H+EQ+ + +M L + + +P+ SS L
Sbjct: 630 YEAPDKDFMIVAL-DLLSGL-AEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFAL 687
Query: 634 LFD-DESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFL 692
L D ++ + + E + I G ++ F + A+GEI +
Sbjct: 688 LGDLTKACFIHVKPCIAEFMP------ILGTNLNPEFISVCNNATWAIGEICMQMGAEMQ 741
Query: 693 PYMESVFEEVFKLLECPH 710
PY++ V + +++ P+
Sbjct: 742 PYVQMVLNNLVEIINRPN 759
Score = 53.9 bits (128), Expect = 8e-07
Identities = 90/443 (20%), Positives = 186/443 (41%), Gaps = 48/443 (10%)
Query: 97 SLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPH 156
S + + A +FR+E L P LL LL+ P +E G+L+L + + P+
Sbjct: 376 SAAALDVLANVFREELL---PHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPY 432
Query: 157 HRELLRLLNETLGEVGSPGLLFYSLR--TLTTMAPYLSTE--DVPLARMLVPKLIMAMQT 212
EL+ L + L + + L S+ TL+ A ++ ++ D+ L ++ L +
Sbjct: 433 LPELIPHLIQCLSDKKA---LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDG 489
Query: 213 LIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLT 272
+ EA AC A L+E +E + PYLS +L + A G + + L L
Sbjct: 490 NKRVQEA-ACSAFATLEEEACTE---LVPYLSYILDTLV-----FAFGK-YQHKNLLILY 539
Query: 273 FLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHF 332
+ + ++ + P + L P L + + ++E+ ++ + E
Sbjct: 540 DAIGTLADSVGHHLNQPEYIQKLMP---------PLIQKWNELKDEDKDLFPLLECLSSV 590
Query: 333 AVQVVDMLALHLPP---------EKLCPQLMPMLEEALRSESPYQ--RKAGLLVLAVLSD 381
A + + P +K Q M + + E+P + L +L+ L++
Sbjct: 591 ATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAE 650
Query: 382 GAGDHIRQRLL-PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLL 440
G G H+ Q + ++ ++ + ++D VR ++ LG ++ H+ E MP+L
Sbjct: 651 GLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPIL 710
Query: 441 LAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRA---- 496
L + ++ A +A+ +G ++QPY+ ++ +++++ P++P+
Sbjct: 711 GTNLNPEFISVCNN---ATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLEN 767
Query: 497 KELAVSALGAIATAAQASLLPYF 519
+ + LG + A +L F
Sbjct: 768 TAITIGRLGYVCPQEVAPMLQQF 790
>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform
2 [Homo sapiens]
Length = 887
Score = 66.2 bits (160), Expect = 2e-10
Identities = 102/438 (23%), Positives = 185/438 (42%), Gaps = 55/438 (12%)
Query: 301 AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA 360
AE P G D ED D ++ + L + + +D+LA ++ E+L P L+P+L+
Sbjct: 349 AERPDGSEDAEDDDDDDALSDWNL-----RKCSAAALDVLA-NVFREELLPHLLPLLKGL 402
Query: 361 LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ 420
L +++G+LVL +++G + LP L+ + + L D +VR+ A + L +
Sbjct: 403 LFHPEWVVKESGILVLGAIAEGCMQGMVP-YLPELIPHLIQCLSDKKALVRSIACWTLSR 461
Query: 421 FSENL--QPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLP 478
++ + QP + PL+ LK + G+ AC A E ++ PYL
Sbjct: 462 YAHWVVSQPP----DMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLS 517
Query: 479 ELMECMLQLLRNPSSPRAKELAV--SALGAIATAAQASL------LPYFPAIMEHLREFL 530
+++ ++ + K L + A+G +A + L P +++ E L
Sbjct: 518 YILDTLVFAF---GKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNE-L 573
Query: 531 LTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC--------------DQ 576
+DL P+ LE L +A A+ P E Q + L +Q
Sbjct: 574 KDEDKDLFPL----LECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQ 629
Query: 577 VDDPDLRRCTYSLFAALSGLMGEGLAPHLEQI---TTLMLLSLRSTEGIVPQYDGSSSFL 633
+ PD +L LSGL EGL H+EQ+ + +M L + + +P+ SS L
Sbjct: 630 YEAPDKDFMIVAL-DLLSGL-AEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFAL 687
Query: 634 LFD-DESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFL 692
L D ++ + + E + I G ++ F + A+GEI +
Sbjct: 688 LGDLTKACFIHVKPCIAEFMP------ILGTNLNPEFISVCNNATWAIGEICMQMGAEMQ 741
Query: 693 PYMESVFEEVFKLLECPH 710
PY++ V + +++ P+
Sbjct: 742 PYVQMVLNNLVEIINRPN 759
Score = 53.9 bits (128), Expect = 8e-07
Identities = 90/443 (20%), Positives = 186/443 (41%), Gaps = 48/443 (10%)
Query: 97 SLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPH 156
S + + A +FR+E L P LL LL+ P +E G+L+L + + P+
Sbjct: 376 SAAALDVLANVFREELL---PHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPY 432
Query: 157 HRELLRLLNETLGEVGSPGLLFYSLR--TLTTMAPYLSTE--DVPLARMLVPKLIMAMQT 212
EL+ L + L + + L S+ TL+ A ++ ++ D+ L ++ L +
Sbjct: 433 LPELIPHLIQCLSDKKA---LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDG 489
Query: 213 LIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLT 272
+ EA AC A L+E +E + PYLS +L + A G + + L L
Sbjct: 490 NKRVQEA-ACSAFATLEEEACTE---LVPYLSYILDTLV-----FAFGK-YQHKNLLILY 539
Query: 273 FLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHF 332
+ + ++ + P + L P L + + ++E+ ++ + E
Sbjct: 540 DAIGTLADSVGHHLNQPEYIQKLMP---------PLIQKWNELKDEDKDLFPLLECLSSV 590
Query: 333 AVQVVDMLALHLPP---------EKLCPQLMPMLEEALRSESPYQ--RKAGLLVLAVLSD 381
A + + P +K Q M + + E+P + L +L+ L++
Sbjct: 591 ATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAE 650
Query: 382 GAGDHIRQRLL-PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLL 440
G G H+ Q + ++ ++ + ++D VR ++ LG ++ H+ E MP+L
Sbjct: 651 GLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPIL 710
Query: 441 LAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRA---- 496
L + ++ A +A+ +G ++QPY+ ++ +++++ P++P+
Sbjct: 711 GTNLNPEFISVCNN---ATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLEN 767
Query: 497 KELAVSALGAIATAAQASLLPYF 519
+ + LG + A +L F
Sbjct: 768 TAITIGRLGYVCPQEVAPMLQQF 790
>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
[Homo sapiens]
Length = 2671
Score = 46.6 bits (109), Expect = 1e-04
Identities = 52/200 (26%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 347 EKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDP 406
EK+ P+++P+LEE LRS+ +R+ + L+ + L+ K L DP
Sbjct: 1958 EKILPEIIPILEEGLRSQKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDP 2017
Query: 407 SQVVRNAALFALGQFSENLQPHISSYSRE-VMPLLLAYLKSVPLGHTHHLAKACYALENF 465
+ VR AA + E L I + E ++P LL L + +AL+
Sbjct: 2018 LEEVREAA----AKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSE--------FALDGL 2065
Query: 466 VENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEH 525
+ + K + LP L+ +L P + R S G T +L PA+M
Sbjct: 2066 KQVMAIKSRVVLPYLVP---KLTTPPVNTRVLAFLSSVAGDALTRHLGVIL---PAVMLA 2119
Query: 526 LREFLLTGREDLQPVQIQSL 545
L+E L T E L+ Q++
Sbjct: 2120 LKEKLGTPDEQLEMANCQAV 2139
Score = 44.7 bits (104), Expect = 5e-04
Identities = 88/374 (23%), Positives = 156/374 (41%), Gaps = 49/374 (13%)
Query: 200 RMLVPKLIMAMQTLIPIDEAKACEALEAL----DELLESEVPVITPYLSEVLTFC---LE 252
++++P L+ A++ +A + E L A+ + L S +P I P L+EVLT ++
Sbjct: 1496 KLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQ 1555
Query: 253 VARNVAL---GNAIRI-RILCCLTFLVKVKSKALLKN-RLLPPLLHTLF------PIVAA 301
A AL G+ IR IL L+ + K + L LL T F P +A
Sbjct: 1556 KAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLAL 1615
Query: 302 EPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEAL 361
P Q +D+ ++ ++ +++G +++ LA +LP + P L+ +L
Sbjct: 1616 IMPIVQRAFQDRSTDTRKMAAQIIGNM---YSLTDQKDLAPYLP------SVTPGLKASL 1666
Query: 362 RSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQF 421
P R L + G G+ + LLP L++ + + S V R+ A L +
Sbjct: 1667 LDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETL---TYEQSSVDRSGAAQGLAEV 1723
Query: 422 SENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVE-NLGPKVQPYLPEL 480
L ++MP ++A V + H+ + N++ G K PY+ +
Sbjct: 1724 MAGLG---VEKLEKLMPEIVATASKVDI--APHVRDGYIMMFNYLPITFGDKFTPYVGPI 1778
Query: 481 MECMLQLLRNPSS---PRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDL 537
+ C+L+ L + + A + A A A LLP L + L +DL
Sbjct: 1779 IPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLP-------QLEQGLF---DDL 1828
Query: 538 QPVQIQSLETLGVL 551
++ S++ LG L
Sbjct: 1829 WRIRFSSVQLLGDL 1842
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 45.4 bits (106), Expect = 3e-04
Identities = 88/401 (21%), Positives = 157/401 (39%), Gaps = 46/401 (11%)
Query: 119 LLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVG---SPG 175
L+Q+L HS +E +L +V++ P +P+ +L+ L L + +PG
Sbjct: 734 LIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPG 793
Query: 176 LLFYSLRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDE--AKACEALEALDELLE 233
++ L T+ +A E R V +L + + ++ AK AL L +L+
Sbjct: 794 VINNVLATIGELAQVSGLE----MRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVA 849
Query: 234 SEVPVITPY-----LSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLL 288
S V+ PY L EVL L+ +N IR+L L L K K +
Sbjct: 850 STGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREA-IRVLGLLGALDPYKHKVNIG---- 904
Query: 289 PPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEK 348
++ A + + D E+ + MG P V M+AL
Sbjct: 905 --MIDQSRDASAVSLSESKSSQDSSDYSTSEMLVN-MGNLPLDEFYPAVSMVAL------ 955
Query: 349 LCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQI--VCKGLEDP 406
+ +++L +A + L + Q ++P L + VC G
Sbjct: 956 ----MRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQ-VMPTFLNVIRVCDG---- 1006
Query: 407 SQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFV 466
+R LG ++ HI Y E++ L+ + + +T + +E V
Sbjct: 1007 --AIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFW----VMNTSIQSTIILLIEQIV 1060
Query: 467 ENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAI 507
LG + + YLP+L+ ML++ + +SP + +++ L AI
Sbjct: 1061 VALGGEFKLYLPQLIPHMLRVFMHDNSP-GRIVSIKLLAAI 1100
Score = 36.2 bits (82), Expect = 0.17
Identities = 45/206 (21%), Positives = 82/206 (39%), Gaps = 21/206 (10%)
Query: 335 QVVDMLALHLPPEKLCPQLMPMLEEALRSESPY-QRKAGLLVLAVLSDGAGDHIRQRLLP 393
Q+V + P + P L+ +L L++E R+ + VL +L GA D + ++
Sbjct: 846 QLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLL--GALDPYKHKVNI 903
Query: 394 PLLQ----------IVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAY 443
++ K +D S + L +G P Y M L+
Sbjct: 904 GMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNL-----PLDEFYPAVSMVALMRI 958
Query: 444 LKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSA 503
+ L H H + A+ ++LG K +LP++M L ++R +E
Sbjct: 959 FRDQSLSHHHTMV--VQAITFIFKSLGLKCVQFLPQVMPTFLNVIR-VCDGAIREFLFQQ 1015
Query: 504 LGAIATAAQASLLPYFPAIMEHLREF 529
LG + + ++ + PY I+ +REF
Sbjct: 1016 LGMLVSFVKSHIRPYMDEIVTLMREF 1041
Score = 30.4 bits (67), Expect = 9.4
Identities = 27/120 (22%), Positives = 50/120 (41%), Gaps = 16/120 (13%)
Query: 468 NLGPKVQPYLPE-------LMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFP 520
NL P++ + P L + M +L + + A ALG ++ A ++ Y P
Sbjct: 394 NLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLP 453
Query: 521 AIMEHLREFL-----LTGREDLQPVQIQSLETLGVLARAVG----EPMRPLAEECCQLGL 571
+++ +R L R+ V + +LARA+G + ++ L E +GL
Sbjct: 454 RVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGL 513
>gi|21361794 TIP120 protein [Homo sapiens]
Length = 1230
Score = 43.1 bits (100), Expect = 0.001
Identities = 66/319 (20%), Positives = 128/319 (40%), Gaps = 41/319 (12%)
Query: 358 EEALRSESPYQRKAGLLVLAVLSDGAGD--HIRQRLLPPLLQIV------------CKGL 403
+++++ + +RK ++L +L D G+ ++ + L PL+ V C +
Sbjct: 36 KDSIKLDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNM 95
Query: 404 EDPSQVVRNAALFALGQFSENLQPHIS--SYSREVMPLLLAYLKSVPLGHTHHLAKACYA 461
+ +R+ + L L P S + + V + L S + ++ A
Sbjct: 96 LSDKEQLRDISSIGLKTVIGELPPASSGSALAANVCKKITGRLTSA-IAKQEDVSVQLEA 154
Query: 462 LENFVENL---GPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPY 518
L+ + L G + + P ++ C+L L +P K + ALG + + +
Sbjct: 155 LDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTII-ALGHLVMSCGNIV--- 210
Query: 519 FPAIMEHLREFLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVD 578
F ++EHL L + D ++ + ++R G + E+ L + C+ VD
Sbjct: 211 FVDLIEHLLSEL--SKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCN-VD 267
Query: 579 DPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDE 638
D +LR F + + + PH+ I + L L P Y+ +DDE
Sbjct: 268 DDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYD----PNYN-------YDDE 316
Query: 639 SDGEEEEELMDEDVEEEDD 657
+E+E MD D ++DD
Sbjct: 317 ---DEDENAMDADGGDDDD 332
Score = 33.9 bits (76), Expect = 0.85
Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 42/245 (17%)
Query: 348 KLCPQLMPMLEEALRSESPYQRKA-GLLVLAVLSDG-AGDHIRQRLLPPLLQIVCKGLED 405
+ CP+ P + + R + +LA+LS G G HI L ++ +
Sbjct: 808 RACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSS 867
Query: 406 PSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGH---THHL-----AK 457
PS+ V++AA +ALG S P E +P +L + S P H L +
Sbjct: 868 PSEEVKSAASYALGSISVGNLP-------EYLPFVLQEITSQPKRQYLLLHSLKEIISSA 920
Query: 458 ACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLP 517
+ L+ +VEN + L + EC + RN + LG + +LLP
Sbjct: 921 SVVGLKPYVEN----IWALLLKHCECAEEGTRN--------VVAECLGKLTLIDPETLLP 968
Query: 518 YFPAIMEHLREFLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQV 577
L+ +L++G + + +++ +P+ PL + C +
Sbjct: 969 -------RLKGYLISGSSYARSSVVTAVK---FTISDHPQPIDPLLKNCIG---DFLKTL 1015
Query: 578 DDPDL 582
+DPDL
Sbjct: 1016 EDPDL 1020
>gi|153791502 transmembrane and coiled-coil domains 7 [Homo sapiens]
Length = 1094
Score = 42.7 bits (99), Expect = 0.002
Identities = 38/158 (24%), Positives = 69/158 (43%), Gaps = 4/158 (2%)
Query: 333 AVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLL 392
A+Q V +L+ + PEK+ P L+ + + +P R VL + GD + +
Sbjct: 898 AIQGVALLS-DVYPEKILPDLLAQYDSSKDKHTPETRMKVGEVLMRIVRALGDMV-SKYR 955
Query: 393 PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHT 452
PL+ +G+ DP R ++L LG+ + L + S EV L+A K+ G
Sbjct: 956 EPLIHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTD--GEV 1013
Query: 453 HHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRN 490
A + + + L K L +++ + LL++
Sbjct: 1014 QVRRAAIHVVVLLLRGLSQKATEVLSAVLKDLYHLLKH 1051
>gi|122937211 KIAA0368 protein [Homo sapiens]
Length = 2017
Score = 38.9 bits (89), Expect = 0.027
Identities = 130/655 (19%), Positives = 237/655 (36%), Gaps = 127/655 (19%)
Query: 223 EALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKAL 282
+A+ ++ L ++ ++ YL E+L ++ +N+ N R+R CL ++ + L
Sbjct: 1312 QAMTSIWNALVTDKSMVDKYLKEILQ---DLVKNLT-SNMWRVRESSCLALNDLLRGRPL 1367
Query: 283 --LKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDML 340
+ ++L P + TLF + +D E EL +T V++ D
Sbjct: 1368 DDIIDKL-PEIWETLFRV------------QDDIKESVRKAAELALKTLSKVCVKMCDPA 1414
Query: 341 ALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQ---RLLPPLLQ 397
+ L +L++ + S R + L +S AG ++ +L+P LL+
Sbjct: 1415 KGAAGQRTIAALLPCLLDKGMMSTVTEVRALSINTLVKISKSAGAMLKPHAPKLIPALLE 1474
Query: 398 IVCKGLEDPSQVVRNAALFALGQF-----SENLQPHISSYSREVMPLLLAYLKSVPLGHT 452
+ + +P QV+ +L A Q S L SS E + + L YL LG
Sbjct: 1475 SL--SVLEP-QVLNYLSLRATEQEKAAMDSARLSAAKSSPMMETINMCLQYLDVSVLG-- 1529
Query: 453 HHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQ 512
EL+ + +L+R+ K S + ++ T
Sbjct: 1530 --------------------------ELVPRLCELIRSGVGLGTKGGCASVIVSLTTQCP 1563
Query: 513 ASLLPYFPAIMEHLREFLLTGREDLQPVQIQSLE-TLGVLARAVGEPMRPLAEECCQLGL 571
L PY +M L L+G D V +S +G L R + E+ Q
Sbjct: 1564 QDLTPYSGKLMSAL----LSGLTDRNSVIQKSCAFAMGHLVRTSRDSS---TEKLLQKLN 1616
Query: 572 GLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSS 631
G + ++P + A+ + L H +++ L L +
Sbjct: 1617 GWYMEKEEPIYKTSCALTIHAIGRYSPDVLKNHAKEVLPLAFLGMHE------------- 1663
Query: 632 FLLFDDESDGEEEEELMDEDVEEEDDSEISGY-------------SVENAFFDEKEDTCA 678
+ D+E +EE L E +E G ++++ + K
Sbjct: 1664 --IADEEKSEKEECNLWTEVWQENVPGSFGGIRLYLQELITITQKALQSQSWKMKAQGAI 1721
Query: 679 AVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKAC-----Q 733
A+ I+ TS PY+ + + + L E L C + AC +
Sbjct: 1722 AMASIAKQTSSLVPPYLGMILTALLQGLAG---RTWAGKEELLKAIACVV-TACSAELEK 1777
Query: 734 SCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPP--G 791
S P++P+T + +QAV +E ++ V + A+ SC LK
Sbjct: 1778 SVPNQPSTNEI-----------LQAVLKECSKENVKYKIVAI-----SCAADILKATKED 1821
Query: 792 RLAELCGVLKAVLQRKTA------CQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP 840
R E ++ ++++ + +EE E+E + Q EY E G+A P
Sbjct: 1822 RFQEFSNIVIPLIKKNSLESSGVRTTKNEEENEKEKELQLEYLLGAFESLGKAWP 1876
Score = 38.1 bits (87), Expect = 0.045
Identities = 103/545 (18%), Positives = 201/545 (36%), Gaps = 63/545 (11%)
Query: 413 AALFALGQFSENLQPHISSYSREVMPLLLAYL--KSVPLGHTHHLAKACYALENFVENLG 470
AA A E P + +V+P +L + K + + H AC L + V L
Sbjct: 1087 AARDAWQMTEEEYTPPAGAKVNDVVPWVLDVILNKHIISPNPHVRQAACIWLLSLVRKLS 1146
Query: 471 P--KVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLRE 528
+V+ +L E+ + +L + + ++++A LG + ++ L E
Sbjct: 1147 THKEVKSHLKEIQSAFVSVL-SENDELSQDVASKGLGLVYELGNEQDQQ---ELVSTLVE 1202
Query: 529 FLLTGREDLQPVQIQSLETLG-VLARAV-GEPMRPLAEECCQLGLGLCDQVDDPDL---- 582
L+TG+ V +++ G L + G+ + E C L + PDL
Sbjct: 1203 TLMTGKRVKHEVSGETVVFQGGALGKTPDGQGLSTYKELC-----SLASDLSQPDLVYKF 1257
Query: 583 ------------RRCTYSLFAALSGLMGEGLAPHLEQITT-LMLLSLRSTEGIVPQYDGS 629
R+ F ++ GE LAP L Q+ L GI
Sbjct: 1258 MNLANHHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSI 1317
Query: 630 SSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSV 689
+ L+ D + +E++ + V+ ++ + + +E +C A+ ++ +
Sbjct: 1318 WNALVTDKSMVDKYLKEILQDLVK----------NLTSNMWRVRESSCLALNDLLRGRPL 1367
Query: 690 A-FLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAAL 748
+ + ++E +F++ + +VRKAA AL L K C AA Q +
Sbjct: 1368 DDIIDKLPEIWETLFRVQDDIKESVRKAAELALK----TLSKVCVKMCDPAKGAAGQRTI 1423
Query: 749 ARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPG-----RLAELCGVLKAV 803
A ++P + +V + L + +S G + LKP L E VL+
Sbjct: 1424 AALLPCLLDKGMMSTVTEVRALSINTLVKISKSAGAM-LKPHAPKLIPALLESLSVLEPQ 1482
Query: 804 LQRKTACQDTDEEEEEEDDDQ--AEYDAMLLEHAGEAIPALAAAAGGDSFAPFFAGFLPL 861
+ + + T++E+ D + A + ++E + L + G+ +P
Sbjct: 1483 VLNYLSLRATEQEKAAMDSARLSAAKSSPMMETINMCLQYLDVSVLGE--------LVPR 1534
Query: 862 LVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIF 921
L + G + K + + +L+ LLS + + ++ + F
Sbjct: 1535 LCELIRSGVGLGTKGGCASVIVSLTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAF 1594
Query: 922 GMGVL 926
MG L
Sbjct: 1595 AMGHL 1599
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 38.5 bits (88), Expect = 0.035
Identities = 51/218 (23%), Positives = 88/218 (40%), Gaps = 36/218 (16%)
Query: 381 DGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQ--PHISSYS----- 433
DG +++R L++IV +D V+ L + + + LQ HI S S
Sbjct: 518 DGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQF 577
Query: 434 REVMPLLLAYLKSVPLGHTHHLA--------------------------KACYALENFVE 467
++ LL A L++V H A A A+ VE
Sbjct: 578 NDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVE 637
Query: 468 NLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLR 527
LG + Y+ + L+N + + AV +G + A Q++++P+ +M+ L
Sbjct: 638 VLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLL 697
Query: 528 EFLLTGREDL-QPVQIQSLETLGVLARAVGEPMRPLAE 564
E L G E++ + V+ Q L G +A A+G + E
Sbjct: 698 ENL--GNENVHRSVKPQILSVFGDIALAIGGEFKKYLE 733
Score = 36.6 bits (83), Expect = 0.13
Identities = 28/135 (20%), Positives = 60/135 (44%), Gaps = 2/135 (1%)
Query: 333 AVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLL 392
A V ML + + P ++P ++E +++ R A ++ + +G + L+
Sbjct: 347 AAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLV 406
Query: 393 PPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHT 452
+ + + ++DPS VVR+ A + +G+ E L P + + PLL ++ +
Sbjct: 407 IQAMPTLIELMKDPSVVVRDTAAWTVGRICE-LLPEAAINDVYLAPLLQCLIEGLS-AEP 464
Query: 453 HHLAKACYALENFVE 467
+ C+A + E
Sbjct: 465 RVASNVCWAFSSLAE 479
>gi|224831257 importin 13 [Homo sapiens]
Length = 963
Score = 38.1 bits (87), Expect = 0.045
Identities = 42/159 (26%), Positives = 66/159 (41%), Gaps = 16/159 (10%)
Query: 6 LEQLLRELLL-PDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVLTRRR 64
+E+ L +L P+ E A + L +P A LL P+I+ F A +
Sbjct: 26 VEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIK 85
Query: 65 LNTRWRRLAAEQRESLKSLILTALQR--------ETEHCVSLSLAQLSATIFRKEGLEAW 116
++ W + +Q ESLK+ + T + R T CV+L+ LS +AW
Sbjct: 86 ISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMM------PDAW 139
Query: 117 PQLLQLLQHSTHSPHSPEREMG-LLLLSVVVTSRPEAFQ 154
P + + + SP G L L ++T PE FQ
Sbjct: 140 PCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQ 178
>gi|57863301 CLIP-associating protein 2 [Homo sapiens]
Length = 1506
Score = 37.7 bits (86), Expect = 0.059
Identities = 30/122 (24%), Positives = 55/122 (45%), Gaps = 8/122 (6%)
Query: 333 AVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLL 392
A + +LA + PE+ L P+++ A + P A + V+ + + + LL
Sbjct: 1375 AEEAASVLATSISPEQCIKVLCPIIQTA---DYPINLAAIKMQTKVIERVSKETLNL-LL 1430
Query: 393 PPLLQIVCKGLEDPSQVVRNAALFAL----GQFSENLQPHISSYSREVMPLLLAYLKSVP 448
P ++ + +G ++ VR A +F L + L+PH+S + M LL Y+K
Sbjct: 1431 PEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQ 1490
Query: 449 LG 450
G
Sbjct: 1491 TG 1492
>gi|115529449 upstream binding transcription factor, RNA polymerase
I isoform b [Homo sapiens]
Length = 727
Score = 37.7 bits (86), Expect = 0.059
Identities = 22/45 (48%), Positives = 27/45 (60%), Gaps = 5/45 (11%)
Query: 636 DDESDGEEEEELMDEDVEEEDD-----SEISGYSVENAFFDEKED 675
+ E D EE+E+ DED EEEDD SE G S E++ DE ED
Sbjct: 639 ESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESED 683
Score = 30.8 bits (68), Expect = 7.2
Identities = 13/40 (32%), Positives = 26/40 (65%)
Query: 637 DESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDT 676
DE++ ++E+E DED +E++D+E G S ++ + D+
Sbjct: 685 DENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSSGDSSDS 724
>gi|115529451 upstream binding transcription factor, RNA polymerase
I isoform b [Homo sapiens]
Length = 727
Score = 37.7 bits (86), Expect = 0.059
Identities = 22/45 (48%), Positives = 27/45 (60%), Gaps = 5/45 (11%)
Query: 636 DDESDGEEEEELMDEDVEEEDD-----SEISGYSVENAFFDEKED 675
+ E D EE+E+ DED EEEDD SE G S E++ DE ED
Sbjct: 639 ESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESED 683
Score = 30.8 bits (68), Expect = 7.2
Identities = 13/40 (32%), Positives = 26/40 (65%)
Query: 637 DESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDT 676
DE++ ++E+E DED +E++D+E G S ++ + D+
Sbjct: 685 DENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSSGDSSDS 724
>gi|7657671 upstream binding transcription factor, RNA polymerase I
isoform a [Homo sapiens]
Length = 764
Score = 37.7 bits (86), Expect = 0.059
Identities = 22/45 (48%), Positives = 27/45 (60%), Gaps = 5/45 (11%)
Query: 636 DDESDGEEEEELMDEDVEEEDD-----SEISGYSVENAFFDEKED 675
+ E D EE+E+ DED EEEDD SE G S E++ DE ED
Sbjct: 676 ESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESED 720
Score = 30.8 bits (68), Expect = 7.2
Identities = 13/40 (32%), Positives = 26/40 (65%)
Query: 637 DESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDT 676
DE++ ++E+E DED +E++D+E G S ++ + D+
Sbjct: 722 DENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSSGDSSDS 761
>gi|63054848 coiled-coil domain containing 34 isoform 1 [Homo
sapiens]
Length = 373
Score = 37.4 bits (85), Expect = 0.077
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 580 PDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDES 639
P R + S ++G G+GL L L ST ++ G SF +D+
Sbjct: 24 PRSRPSSDSCSVPMTGARGQGLEVVRSPSPPLPLSCSNSTRSLLSPL-GHQSFQFDEDDG 82
Query: 640 DGEEEEELMDEDVEEED--DSE 659
DGE+EE++ DE+ +ED DSE
Sbjct: 83 DGEDEEDVDDEEDVDEDAHDSE 104
>gi|18087817 coiled-coil domain containing 34 isoform 2 [Homo
sapiens]
Length = 229
Score = 37.4 bits (85), Expect = 0.077
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 580 PDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDES 639
P R + S ++G G+GL L L ST ++ G SF +D+
Sbjct: 24 PRSRPSSDSCSVPMTGARGQGLEVVRSPSPPLPLSCSNSTRSLLSPL-GHQSFQFDEDDG 82
Query: 640 DGEEEEELMDEDVEEED--DSE 659
DGE+EE++ DE+ +ED DSE
Sbjct: 83 DGEDEEDVDDEEDVDEDAHDSE 104
>gi|4505999 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 36.6 bits (83), Expect = 0.13
Identities = 25/61 (40%), Positives = 31/61 (50%), Gaps = 4/61 (6%)
Query: 615 SLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKE 674
S S +P+ S F +DESD EEEE E+ EE+D GYS E A +E E
Sbjct: 240 SCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEED----GYSSEEAENEEDE 295
Query: 675 D 675
D
Sbjct: 296 D 296
>gi|29826282 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 36.6 bits (83), Expect = 0.13
Identities = 25/61 (40%), Positives = 31/61 (50%), Gaps = 4/61 (6%)
Query: 615 SLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKE 674
S S +P+ S F +DESD EEEE E+ EE+D GYS E A +E E
Sbjct: 240 SCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEED----GYSSEEAENEEDE 295
Query: 675 D 675
D
Sbjct: 296 D 296
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 36.2 bits (82), Expect = 0.17
Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 603 PHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEE-EDDSEIS 661
P L+ ++TL+++ + E + + ++E + +EEEE +ED EE E+D E +
Sbjct: 1840 PVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEET 1899
Query: 662 GYSVENAFFDEKEDTCAAVGE 682
E+ +EKE+ AA GE
Sbjct: 1900 AQEKED---EEKEEEEAAEGE 1917
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 36.2 bits (82), Expect = 0.17
Identities = 25/81 (30%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 603 PHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEE-EDDSEIS 661
P L+ ++TL+++ + E + + ++E + +EEEE +ED EE E+D E +
Sbjct: 1840 PVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEET 1899
Query: 662 GYSVENAFFDEKEDTCAAVGE 682
E+ +EKE+ AA GE
Sbjct: 1900 AQEKED---EEKEEEEAAEGE 1917
>gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member A [Homo sapiens]
Length = 249
Score = 35.8 bits (81), Expect = 0.22
Identities = 34/123 (27%), Positives = 57/123 (46%), Gaps = 9/123 (7%)
Query: 557 EPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMG----EGLAPHLEQITTLM 612
EP++ L E L L C+ + D R + L L+ L G + AP + +
Sbjct: 107 EPLKKL-ENLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVE 165
Query: 613 LLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDE 672
L + +YD + + +DE D +EEEE +EDV E++ + GY+ + D+
Sbjct: 166 GLDDEEEDEDEEEYDEDAQVV--EDEEDEDEEEEGEEEDVSGEEEEDEEGYN--DGEVDD 221
Query: 673 KED 675
+ED
Sbjct: 222 EED 224
>gi|21361659 importin 9 [Homo sapiens]
Length = 1041
Score = 35.8 bits (81), Expect = 0.22
Identities = 40/134 (29%), Positives = 57/134 (42%), Gaps = 17/134 (12%)
Query: 5 GLEQLLRELL---LPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQ----IRQFA 57
GL++ L + L L + +R A E+ VL L DPQ IRQ A
Sbjct: 20 GLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGV--HLAELTVDPQGALAIRQLA 77
Query: 58 AVLTRRRLNTRW-----RRLAAEQRESLKSLILTALQ---RETEHCVSLSLAQLSATIFR 109
+V+ ++ + T W + E E K +I L RE+ V S+A + I
Sbjct: 78 SVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRESISKVRSSVAYAVSAIAH 137
Query: 110 KEGLEAWPQLLQLL 123
+ EAWPQL LL
Sbjct: 138 WDWPEAWPQLFNLL 151
>gi|119709834 castor homolog 1, zinc finger isoform a [Homo sapiens]
Length = 1759
Score = 35.4 bits (80), Expect = 0.29
Identities = 19/52 (36%), Positives = 30/52 (57%), Gaps = 1/52 (1%)
Query: 811 QDTDEEEEEEDDDQAEYDAMLLEHAGEAIP-ALAAAAGGDSFAPFFAGFLPL 861
+D DE++++EDDD+ + D L + E++P A A AAG + P A L
Sbjct: 1695 EDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAAAEAAGAGARTPALAALAAL 1746
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,061,360
Number of Sequences: 37866
Number of extensions: 1879719
Number of successful extensions: 16128
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 13261
Number of HSP's gapped (non-prelim): 2355
length of query: 1081
length of database: 18,247,518
effective HSP length: 113
effective length of query: 968
effective length of database: 13,968,660
effective search space: 13521662880
effective search space used: 13521662880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.