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Search of human proteins with 62234461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
(485 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 989 0.0
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 388 e-108
gi|32189425 WD repeat domain 69 [Homo sapiens] 150 3e-36
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 134 1e-31
gi|16554629 WD repeat domain 5 [Homo sapiens] 132 5e-31
gi|16554627 WD repeat domain 5 [Homo sapiens] 132 5e-31
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 130 3e-30
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 130 3e-30
gi|23199987 WD repeat domain 5B [Homo sapiens] 130 3e-30
gi|26665869 WD repeat domain 51B [Homo sapiens] 129 6e-30
gi|19913367 transducin beta-like 1Y [Homo sapiens] 125 1e-28
gi|19913365 transducin beta-like 1Y [Homo sapiens] 125 1e-28
gi|15150805 transducin beta-like 1Y [Homo sapiens] 125 1e-28
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 124 1e-28
gi|113865883 WD repeat domain 38 [Homo sapiens] 120 3e-27
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 120 4e-27
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 120 4e-27
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 120 4e-27
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 120 4e-27
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 113 3e-25
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 113 4e-25
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 113 4e-25
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 113 4e-25
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 111 1e-24
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 111 2e-24
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 111 2e-24
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 111 2e-24
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 110 2e-24
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 110 2e-24
gi|157266266 WD repeat domain 86 [Homo sapiens] 108 1e-23
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 989 bits (2558), Expect = 0.0
Identities = 485/485 (100%), Positives = 485/485 (100%)
Query: 1 MAAAVPDEAVARDVQRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPL 60
MAAAVPDEAVARDVQRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPL
Sbjct: 1 MAAAVPDEAVARDVQRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPL 60
Query: 61 AFFVHDAEIVSSLGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISV 120
AFFVHDAEIVSSLGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISV
Sbjct: 61 AFFVHDAEIVSSLGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISV 120
Query: 121 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180
AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI
Sbjct: 121 AFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQI 180
Query: 181 LLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCER 240
LLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCER
Sbjct: 181 LLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCER 240
Query: 241 ILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYA 300
ILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYA
Sbjct: 241 ILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYA 300
Query: 301 LRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAE 360
LRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAE
Sbjct: 301 LRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAE 360
Query: 361 DKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQI 420
DKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQI
Sbjct: 361 DKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQI 420
Query: 421 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCL 480
AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCL
Sbjct: 421 AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCL 480
Query: 481 RIWRR 485
RIWRR
Sbjct: 481 RIWRR 485
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 388 bits (997), Expect = e-108
Identities = 193/193 (100%), Positives = 193/193 (100%)
Query: 293 MALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFT 352
MALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFT
Sbjct: 1 MALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFT 60
Query: 353 LFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRG 412
LFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRG
Sbjct: 61 LFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRG 120
Query: 413 HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVA 472
HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVA
Sbjct: 121 HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVA 180
Query: 473 SGGKDKCLRIWRR 485
SGGKDKCLRIWRR
Sbjct: 181 SGGKDKCLRIWRR 193
Score = 77.8 bits (190), Expect = 2e-14
Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 8/147 (5%)
Query: 129 LASGSGDTTVRFWDLSTETPHFT-CKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPST 187
L SGS D T+ W + + T GH+ + + +SPD R +AS + I LWD T
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 111
Query: 188 GKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQ 247
GK + +L GH + ++W + + R + S S D ++++WD A + L GH
Sbjct: 112 GKYLA-SLRGHVAAVYQIAW-----SADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD 165
Query: 248 SVTCLRWGGDG-LLYSASQDRTIKVWR 273
V + W DG + S +D+ +++WR
Sbjct: 166 EVYAVDWSPDGQRVASGGKDKCLRIWR 192
Score = 72.4 bits (176), Expect = 9e-13
Identities = 40/122 (32%), Positives = 61/122 (50%), Gaps = 6/122 (4%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
+ GH + V FSP + +AS S D +++ WD T + +GH V I+WS D R
Sbjct: 76 MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSR 135
Query: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
L SG + + +WD K + L GH+ + + W +P+ + VAS KD +R
Sbjct: 136 LLVSGSSDSTLKVWDVKAQK-LAMDLPGHADEVYAVDW-----SPDGQRVASGGKDKCLR 189
Query: 230 IW 231
IW
Sbjct: 190 IW 191
Score = 70.1 bits (170), Expect = 4e-12
Identities = 43/130 (33%), Positives = 62/130 (47%), Gaps = 6/130 (4%)
Query: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
+L SG + + LW P+ K+ + GH I + + +P+ R VAS+S D S++
Sbjct: 51 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLF-----SPDSRIVASASFDKSIK 105
Query: 230 IWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGH 288
+WD G+ L GH +V + W D LL S S D T+KVW L L GH
Sbjct: 106 LWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHAD 165
Query: 289 WVNTMALSTD 298
V + S D
Sbjct: 166 EVYAVDWSPD 175
Score = 66.2 bits (160), Expect = 6e-11
Identities = 29/76 (38%), Positives = 46/76 (60%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167
+SL GH AV +A+S + L SGS D+T++ WD+ + GH V ++ WSPD
Sbjct: 116 ASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPD 175
Query: 168 GRKLASGCKNGQILLW 183
G+++ASG K+ + +W
Sbjct: 176 GQRVASGGKDKCLRIW 191
Score = 49.3 bits (116), Expect = 8e-06
Identities = 46/183 (25%), Positives = 72/183 (39%), Gaps = 45/183 (24%)
Query: 219 VASSSKDGSVRIWDTTAGRCERI-LTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHD 276
+ S S D ++ +W + +TGH + + + D ++ SAS D++IK+W
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 111
Query: 277 GVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
G +L+GH V +A S D L
Sbjct: 112 GKYLASLRGHVAAVYQIAWSADSRL----------------------------------- 136
Query: 337 RGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSI 396
LVSGS D TL +W K + + GH + V +SPD + VAS DK +
Sbjct: 137 -------LVSGSSDSTLKVWDVKAQKLAMD-LPGHADEVYAVDWSPDGQRVASGGKDKCL 188
Query: 397 KLW 399
++W
Sbjct: 189 RIW 191
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 150 bits (378), Expect = 3e-36
Identities = 105/377 (27%), Positives = 174/377 (46%), Gaps = 51/377 (13%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS-PDG 168
L+ H + +VA + +G +GS D T + WD ++ T +GHR+ V +I+++ P G
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
Query: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
K+A+G + LW TGK T GH+ I LS+ NP+ VA+ S D +
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCY-HTFRGHTAEIVCLSF-----NPQSTLVATGSMDTTA 201
Query: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
++WD G L GH+ + L + G + + S D T+ VW A G L GH
Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261
Query: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
+++ + + D +L +++G
Sbjct: 262 AEISSASFNWDCSL------------------------------------------ILTG 279
Query: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
S D T LW A + K + +TGH I F +++A+AS D + +++ T K +
Sbjct: 280 SMDKTCKLWD-ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCI 338
Query: 408 ASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPD 467
A L GH + +I+++ L++GSSD T ++WD + + L GH DE+++ ++
Sbjct: 339 AKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK 398
Query: 468 GQRVASGGKDKCLRIWR 484
G V +G KD RIWR
Sbjct: 399 GNIVITGSKDNTCRIWR 415
Score = 142 bits (358), Expect = 7e-34
Identities = 94/336 (27%), Positives = 160/336 (47%), Gaps = 51/336 (15%)
Query: 108 SSLEGHSEAVISVAFS-PTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSP 166
++LEGH V ++AF+ P G +A+GS D T + W + T + T +GH ++ +S++P
Sbjct: 128 NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP 187
Query: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
+A+G + LWD G++V TL GHS I LS+ N + + S D
Sbjct: 188 QSTLVATGSMDTTAKLWDIQNGEEV-YTLRGHSAEIISLSF-----NTSGDRIITGSFDH 241
Query: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDRTIKVWRAHDGVLCRTLQG 285
+V +WD GR IL GH ++ + D L+ + S D+T K+W A +G TL G
Sbjct: 242 TVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTG 301
Query: 286 HGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLV 345
H D + F D G L +
Sbjct: 302 H-----------DDEILDSCF----------DYTGKL---------------------IA 319
Query: 346 SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405
+ S D T ++S A +K + ++ GH+ I+++ F+P + + S DK+ ++WD +TG+
Sbjct: 320 TASADGTARIFS-AATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378
Query: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
L L GH ++ A++ ++++GS D+T ++W
Sbjct: 379 CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 113 bits (282), Expect = 4e-25
Identities = 76/297 (25%), Positives = 135/297 (45%), Gaps = 52/297 (17%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
+C + GH+ ++ ++F+P +A+GS DTT + WD+ +T +GH ++S+S+
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
+ G ++ +G + +++WD TG++V L GH I+ S+ N +C + + S
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKV-NILIGHCAEISSASF-----NWDCSLILTGSM 281
Query: 225 DGSVRIWDTTAGRCERILTGHTQSV--TCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRT 282
D + ++WD T G+C LTGH + +C + G L+ +AS D T +++ A
Sbjct: 282 DKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK-LIATASADGTARIFSAATRKCIAK 340
Query: 283 LQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPE 342
L+GH E ++ S NPQ
Sbjct: 341 LEGH------------------EGEISKISFNPQG------------------------N 358
Query: 343 RLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
L++GS D T +W A+ + L + GH I F+ IV + S D + ++W
Sbjct: 359 HLLTGSSDKTARIWD-AQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 57.0 bits (136), Expect = 4e-08
Identities = 25/82 (30%), Positives = 42/82 (51%)
Query: 102 AVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161
A +C + LEGH + ++F+P G +L +GS D T R WD T +GH + S
Sbjct: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS 392
Query: 162 ISWSPDGRKLASGCKNGQILLW 183
+++ G + +G K+ +W
Sbjct: 393 CAFNYKGNIVITGSKDNTCRIW 414
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 134 bits (338), Expect = 1e-31
Identities = 93/337 (27%), Positives = 155/337 (45%), Gaps = 30/337 (8%)
Query: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
+L GH V V F P + S S D T++ WD T T KGH V IS+ G
Sbjct: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
Query: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
+ LAS + I LWD G + RT+ GH ++ ++ P ++ S+S+D ++
Sbjct: 163 KLLASCSADMTIKLWD-FQGFECIRTMHGHDHNVSSVA-----IMPNGDHIVSASRDKTI 216
Query: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
++W+ G C + TGH + V +R DG L+ S S D+T++VW L+ H
Sbjct: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHE 276
Query: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
H V ++ + P+ S+ E A G+ L+SG
Sbjct: 277 HVVECISWA------------------PESSYSSISE----ATGSETKKSGKPGPFLLSG 314
Query: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
S D T+ +W + +T + GH + VLF + + S + DK++++WD + + +
Sbjct: 315 SRDKTIKMWDVSTGMCLMT-LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 408 ASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
+L H V + + + +V+GS D T+KVW+ +
Sbjct: 374 KTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 120 bits (302), Expect = 2e-27
Identities = 88/336 (26%), Positives = 149/336 (44%), Gaps = 32/336 (9%)
Query: 150 FTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP 209
+ GHR V + + P + S ++ I +WD TG RTL GH+ + +S++
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG-DFERTLKGHTDSVQDISFD- 159
Query: 210 LHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVT--CLRWGGDGLLYSASQDR 267
H+ + +AS S D ++++WD C R + GH +V+ + GD ++ SAS+D+
Sbjct: 160 -HSG---KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV-SASRDK 214
Query: 268 TIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE 327
TIK+W G +T GH WV + + D L V + EL+E
Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE 274
Query: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIV 387
E +V W+P ++ TG + + +
Sbjct: 275 H-------------EHVVE------CISWAPESSYSSISEATGSETKKS----GKPGPFL 311
Query: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 447
S S DK+IK+WD TG L +L GH V + + + + ++S + D TL+VWD K ++
Sbjct: 312 LSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKR 371
Query: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
L H V ++D+ V +G D+ +++W
Sbjct: 372 CMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 95.9 bits (237), Expect = 7e-20
Identities = 59/205 (28%), Positives = 95/205 (46%), Gaps = 19/205 (9%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C ++ GH V SVA P G ++ S S D T++ W++ T T GHR WV + +
Sbjct: 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPN 243
Query: 166 PDGRKLASGCKNGQ-ILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECR------- 217
DG +AS C N Q + +W +T K+ L H + +SW P +
Sbjct: 244 QDGTLIAS-CSNDQTVRVWVVAT-KECKAELREHEHVVECISWAPESSYSSISEATGSET 301
Query: 218 --------YVASSSKDGSVRIWDTTAGRCERILTGHTQSVT-CLRWGGDGLLYSASQDRT 268
++ S S+D ++++WD + G C L GH V L G + S + D+T
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
Query: 269 IKVWRAHDGVLCRTLQGHGHWVNTM 293
++VW + +TL H H+V ++
Sbjct: 362 LRVWDYKNKRCMKTLNAHEHFVTSL 386
Score = 91.3 bits (225), Expect = 2e-18
Identities = 50/167 (29%), Positives = 87/167 (52%), Gaps = 14/167 (8%)
Query: 317 DLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALIN 376
+L+ L E KE S L + + P+ W P +K ++GH++ +
Sbjct: 67 ELESKLNEAKEEFTSGGPLGQKRDPKE------------WIPRPPEK--YALSGHRSPVT 112
Query: 377 QVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDS 436
+V+F P ++ SAS D +IK+WD TG + +L+GH +V I++ +LL S S+D
Sbjct: 113 RVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADM 172
Query: 437 TLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
T+K+WD + + + GH V +V P+G + S +DK +++W
Sbjct: 173 TIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
Score = 46.2 bits (108), Expect = 7e-05
Identities = 22/79 (27%), Positives = 37/79 (46%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C +L GH V V F GK++ S + D T+R WD + T H H+V S+ +
Sbjct: 330 CLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFH 389
Query: 166 PDGRKLASGCKNGQILLWD 184
+ +G + + +W+
Sbjct: 390 KTAPYVVTGSVDQTVKVWE 408
Score = 36.2 bits (82), Expect = 0.069
Identities = 15/38 (39%), Positives = 21/38 (55%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
RC +L H V S+ F T Y+ +GS D TV+ W+
Sbjct: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 132 bits (333), Expect = 5e-31
Identities = 89/307 (28%), Positives = 153/307 (49%), Gaps = 32/307 (10%)
Query: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
+L GH++AV SV FSP G++LAS S D ++ W T GH+ + ++WS D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
L S + + +WD S+GK + +TL GHS ++ ++ NP+ + S S D SV
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFCCNF-----NPQSNLIVSGSFDESV 153
Query: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL---- 283
RIWD G+C + L H+ V+ + + DG L+ S+S D ++W G +TL
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 284 ---------QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYN 334
+G ++ +A + D L+ + + + G E K + ++
Sbjct: 214 NPPVSFVKFSPNGKYI--LAATLDNTLKLWDYSKGKCL---KTYTGHKNE-KYCIFANFS 267
Query: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF-- 392
+ G+ +VSGS+D +++W+ + K+ + ++ GH ++ P I+ASA+
Sbjct: 268 VTGGKW---IVSGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISTACHPTENIIASAALEN 323
Query: 393 DKSIKLW 399
DK+IKLW
Sbjct: 324 DKTIKLW 330
Score = 130 bits (326), Expect = 3e-30
Identities = 89/341 (26%), Positives = 154/341 (45%), Gaps = 54/341 (15%)
Query: 150 FTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP 209
FT GH V S+ +SP+G LAS + I +W GK +T++GH I+ ++W
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-FEKTISGHKLGISDVAW-- 95
Query: 210 LHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRT 268
+ + + S+S D +++IWD ++G+C + L GH+ V C + L+ S S D +
Sbjct: 96 ---SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152
Query: 269 IKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328
+++W G +TL H V+ + + D GSL
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRD---------------------GSL------ 185
Query: 329 ALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVA 388
+VS S D +W A + T + ++ V FSP+ + +
Sbjct: 186 ---------------IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230
Query: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS---ADSRLLVSGSSDSTLKVWDVKA 445
+A+ D ++KLWD GK L + GH Y I + + +VSGS D+ + +W+++
Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
Query: 446 QKLAMDLPGHADEVYAVDWSPDGQRVASGG--KDKCLRIWR 484
+++ L GH D V + P +AS DK +++W+
Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 90.5 bits (223), Expect = 3e-18
Identities = 52/208 (25%), Positives = 100/208 (48%), Gaps = 10/208 (4%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
+C +L+GHS V F+P + SGS D +VR WD+ T T H V ++ +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
+ DG + S +G +WD ++G+ + + + ++ + + +P +Y+ +++
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF-----SPNGKYILAATL 234
Query: 225 DGSVRIWDTTAGRCERILTGHTQSVTCL----RWGGDGLLYSASQDRTIKVWRAHDGVLC 280
D ++++WD + G+C + TGH C+ G + S S+D + +W +
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Query: 281 RTLQGHGHWV-NTMALSTDYALRTGAFE 307
+ LQGH V +T T+ + + A E
Sbjct: 295 QKLQGHTDVVISTACHPTENIIASAALE 322
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/217 (22%), Positives = 89/217 (41%), Gaps = 29/217 (13%)
Query: 21 FQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLGKTLESQ 80
F + ++ FD V I + L A DP+ F D ++ S
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS------ 190
Query: 81 AVETEKVLDIIYQPQAIFRVRAVTRCTSSL-EGHSEAVISVAFSPTGKYLASGSGDTTVR 139
Y A +C +L + + V V FSP GKY+ + + D T++
Sbjct: 191 -----------YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239
Query: 140 FWDLSTETPHFTCKGHRH--WVLSISWSPDGRK-LASGCKNGQILLWDPSTGKQVGRTLA 196
WD S T GH++ + + ++S G K + SG ++ + +W+ T K++ + L
Sbjct: 240 LWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQ 298
Query: 197 GHSKWITGLSWEPLHANPECRYVASSS--KDGSVRIW 231
GH+ + + P +AS++ D ++++W
Sbjct: 299 GHTDVVISTACHPTE-----NIIASAALENDKTIKLW 330
Score = 34.7 bits (78), Expect = 0.20
Identities = 15/36 (41%), Positives = 22/36 (61%)
Query: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
L L GH V +V +SP+G+ +AS DK ++IW
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 132 bits (333), Expect = 5e-31
Identities = 89/307 (28%), Positives = 153/307 (49%), Gaps = 32/307 (10%)
Query: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
+L GH++AV SV FSP G++LAS S D ++ W T GH+ + ++WS D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
L S + + +WD S+GK + +TL GHS ++ ++ NP+ + S S D SV
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFCCNF-----NPQSNLIVSGSFDESV 153
Query: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL---- 283
RIWD G+C + L H+ V+ + + DG L+ S+S D ++W G +TL
Sbjct: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 284 ---------QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYN 334
+G ++ +A + D L+ + + + G E K + ++
Sbjct: 214 NPPVSFVKFSPNGKYI--LAATLDNTLKLWDYSKGKCL---KTYTGHKNE-KYCIFANFS 267
Query: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF-- 392
+ G+ +VSGS+D +++W+ + K+ + ++ GH ++ P I+ASA+
Sbjct: 268 VTGGKW---IVSGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISTACHPTENIIASAALEN 323
Query: 393 DKSIKLW 399
DK+IKLW
Sbjct: 324 DKTIKLW 330
Score = 130 bits (326), Expect = 3e-30
Identities = 89/341 (26%), Positives = 154/341 (45%), Gaps = 54/341 (15%)
Query: 150 FTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP 209
FT GH V S+ +SP+G LAS + I +W GK +T++GH I+ ++W
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-FEKTISGHKLGISDVAW-- 95
Query: 210 LHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRT 268
+ + + S+S D +++IWD ++G+C + L GH+ V C + L+ S S D +
Sbjct: 96 ---SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152
Query: 269 IKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328
+++W G +TL H V+ + + D GSL
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRD---------------------GSL------ 185
Query: 329 ALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVA 388
+VS S D +W A + T + ++ V FSP+ + +
Sbjct: 186 ---------------IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230
Query: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS---ADSRLLVSGSSDSTLKVWDVKA 445
+A+ D ++KLWD GK L + GH Y I + + +VSGS D+ + +W+++
Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
Query: 446 QKLAMDLPGHADEVYAVDWSPDGQRVASGG--KDKCLRIWR 484
+++ L GH D V + P +AS DK +++W+
Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
Score = 90.5 bits (223), Expect = 3e-18
Identities = 52/208 (25%), Positives = 100/208 (48%), Gaps = 10/208 (4%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
+C +L+GHS V F+P + SGS D +VR WD+ T T H V ++ +
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
Query: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
+ DG + S +G +WD ++G+ + + + ++ + + +P +Y+ +++
Sbjct: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF-----SPNGKYILAATL 234
Query: 225 DGSVRIWDTTAGRCERILTGHTQSVTCL----RWGGDGLLYSASQDRTIKVWRAHDGVLC 280
D ++++WD + G+C + TGH C+ G + S S+D + +W +
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Query: 281 RTLQGHGHWV-NTMALSTDYALRTGAFE 307
+ LQGH V +T T+ + + A E
Sbjct: 295 QKLQGHTDVVISTACHPTENIIASAALE 322
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/217 (22%), Positives = 89/217 (41%), Gaps = 29/217 (13%)
Query: 21 FQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLGKTLESQ 80
F + ++ FD V I + L A DP+ F D ++ S
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS------ 190
Query: 81 AVETEKVLDIIYQPQAIFRVRAVTRCTSSL-EGHSEAVISVAFSPTGKYLASGSGDTTVR 139
Y A +C +L + + V V FSP GKY+ + + D T++
Sbjct: 191 -----------YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239
Query: 140 FWDLSTETPHFTCKGHRH--WVLSISWSPDGRK-LASGCKNGQILLWDPSTGKQVGRTLA 196
WD S T GH++ + + ++S G K + SG ++ + +W+ T K++ + L
Sbjct: 240 LWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQ 298
Query: 197 GHSKWITGLSWEPLHANPECRYVASSS--KDGSVRIW 231
GH+ + + P +AS++ D ++++W
Sbjct: 299 GHTDVVISTACHPTE-----NIIASAALENDKTIKLW 330
Score = 34.7 bits (78), Expect = 0.20
Identities = 15/36 (41%), Positives = 22/36 (61%)
Query: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
L L GH V +V +SP+G+ +AS DK ++IW
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 130 bits (327), Expect = 3e-30
Identities = 93/337 (27%), Positives = 149/337 (44%), Gaps = 52/337 (15%)
Query: 149 HFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE 208
HF KGHR V + +S + ++LASG + +++W + R GH +T +++
Sbjct: 14 HF--KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNF- 69
Query: 209 PLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDR 267
+P +AS S+D +VRIW + HT +V + + DG + +AS D+
Sbjct: 70 ----SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 268 TIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE 327
T+KVW H +L H +WV S D L
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL-------------------------- 159
Query: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIV 387
+VS SDD T+ LW + ++ + H + V F P +
Sbjct: 160 ----------------IVSASDDKTVKLWDKSS-RECVHSYCEHGGFVTYVDFHPSGTCI 202
Query: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 447
A+A D ++K+WD RT + L + H AAV +++ L++ SSDSTLK+ D+ +
Sbjct: 203 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 262
Query: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
L L GH V +S G+ ASGG D+ + +W+
Sbjct: 263 LLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 106 bits (265), Expect = 4e-23
Identities = 81/332 (24%), Positives = 137/332 (41%), Gaps = 50/332 (15%)
Query: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
+GH +AV V FS K LASGS D+ + W + ++ + GH+ V +++SP G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
LASG ++ + +W P+ K H+ + +H + + ++S D +V++
Sbjct: 76 LASGSRDKTVRIWVPNV-KGESTVFRAHTATV-----RSVHFCSDGQSFVTASDDKTVKV 129
Query: 231 WDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHW 289
W T + L+ H V C ++ DG L+ SAS D+T+K+W + HG +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 290 VNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349
V + F P+ + +
Sbjct: 190 VTYV-----------DFHPSGTCI-------------------------------AAAGM 207
Query: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409
D T+ +W + L H A +N + F P + +AS D ++K+ D G+ L +
Sbjct: 208 DNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
Query: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
L GH +A+S SG SD + VW
Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 71.6 bits (174), Expect = 1e-12
Identities = 49/169 (28%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST-ETPHFTCKGHRHWVLSISWSPD 167
SL H V FSP G+ + S S D TV+ WD S+ E H C+ H +V + + P
Sbjct: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPS 198
Query: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
G +A+ + + +WD T + + + HS + GLS+ +P Y+ ++S D +
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSF-----HPSGNYLITASSDST 252
Query: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAH 275
++I D GR L GH T + + G + S D + VW+++
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
Score = 62.4 bits (150), Expect = 9e-10
Identities = 35/125 (28%), Positives = 57/125 (45%)
Query: 359 AEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 418
AED GH+ + V FS +++ +AS S D + +W + GH AV
Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 419 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478
+ +S LL SGS D T+++W + + H V +V + DGQ + DK
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 479 CLRIW 483
+++W
Sbjct: 126 TVKVW 130
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 6/126 (4%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C S H V V F P+G +A+ D TV+ WD+ T + H V +S+
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
Query: 166 PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
P G L + + + + D G+ + TL GH T +++ + Y AS D
Sbjct: 239 PSGNYLITASSDSTLKILDLMEGRLL-YTLHGHQGPATTVAF-----SRTGEYFASGGSD 292
Query: 226 GSVRIW 231
V +W
Sbjct: 293 EQVMVW 298
Score = 36.6 bits (83), Expect = 0.053
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFW 141
R +L GH +VAFS TG+Y ASG D V W
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 130 bits (327), Expect = 3e-30
Identities = 93/337 (27%), Positives = 149/337 (44%), Gaps = 52/337 (15%)
Query: 149 HFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWE 208
HF KGHR V + +S + ++LASG + +++W + R GH +T +++
Sbjct: 14 HF--KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNF- 69
Query: 209 PLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDR 267
+P +AS S+D +VRIW + HT +V + + DG + +AS D+
Sbjct: 70 ----SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 268 TIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE 327
T+KVW H +L H +WV S D L
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL-------------------------- 159
Query: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIV 387
+VS SDD T+ LW + ++ + H + V F P +
Sbjct: 160 ----------------IVSASDDKTVKLWDKSS-RECVHSYCEHGGFVTYVDFHPSGTCI 202
Query: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 447
A+A D ++K+WD RT + L + H AAV +++ L++ SSDSTLK+ D+ +
Sbjct: 203 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 262
Query: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
L L GH V +S G+ ASGG D+ + +W+
Sbjct: 263 LLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 106 bits (265), Expect = 4e-23
Identities = 81/332 (24%), Positives = 137/332 (41%), Gaps = 50/332 (15%)
Query: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
+GH +AV V FS K LASGS D+ + W + ++ + GH+ V +++SP G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
LASG ++ + +W P+ K H+ + +H + + ++S D +V++
Sbjct: 76 LASGSRDKTVRIWVPNV-KGESTVFRAHTATV-----RSVHFCSDGQSFVTASDDKTVKV 129
Query: 231 WDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHW 289
W T + L+ H V C ++ DG L+ SAS D+T+K+W + HG +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 290 VNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349
V + F P+ + +
Sbjct: 190 VTYV-----------DFHPSGTCI-------------------------------AAAGM 207
Query: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409
D T+ +W + L H A +N + F P + +AS D ++K+ D G+ L +
Sbjct: 208 DNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
Query: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
L GH +A+S SG SD + VW
Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 71.6 bits (174), Expect = 1e-12
Identities = 49/169 (28%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST-ETPHFTCKGHRHWVLSISWSPD 167
SL H V FSP G+ + S S D TV+ WD S+ E H C+ H +V + + P
Sbjct: 140 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPS 198
Query: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
G +A+ + + +WD T + + + HS + GLS+ +P Y+ ++S D +
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSF-----HPSGNYLITASSDST 252
Query: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAH 275
++I D GR L GH T + + G + S D + VW+++
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
Score = 62.4 bits (150), Expect = 9e-10
Identities = 35/125 (28%), Positives = 57/125 (45%)
Query: 359 AEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 418
AED GH+ + V FS +++ +AS S D + +W + GH AV
Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 419 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478
+ +S LL SGS D T+++W + + H V +V + DGQ + DK
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 479 CLRIW 483
+++W
Sbjct: 126 TVKVW 130
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 6/126 (4%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C S H V V F P+G +A+ D TV+ WD+ T + H V +S+
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238
Query: 166 PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
P G L + + + + D G+ + TL GH T +++ + Y AS D
Sbjct: 239 PSGNYLITASSDSTLKILDLMEGRLL-YTLHGHQGPATTVAF-----SRTGEYFASGGSD 292
Query: 226 GSVRIW 231
V +W
Sbjct: 293 EQVMVW 298
Score = 36.6 bits (83), Expect = 0.053
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFW 141
R +L GH +VAFS TG+Y ASG D V W
Sbjct: 262 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 130 bits (326), Expect = 3e-30
Identities = 91/348 (26%), Positives = 156/348 (44%), Gaps = 58/348 (16%)
Query: 146 ETPHFTCK----GHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKW 201
E P++ K GH V S+ +SP+G LAS + I++W GK +TL GH+
Sbjct: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-KTLYGHNLE 85
Query: 202 ITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG-DGLL 260
I+ ++W + + + S+S D ++++WD +G+C + L GH+ V C + L+
Sbjct: 86 ISDVAW-----SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLI 140
Query: 261 YSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQG 320
S S D T+K+W G +TL H V+ + + G
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCS---------------------G 179
Query: 321 SLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLF 380
SL +VSGS D +W A + T + ++ V F
Sbjct: 180 SL---------------------IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 381 SPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS---ADSRLLVSGSSDST 437
SP+ + + +A+ D ++KLWD G+ L + GH Y I + + +VSGS D+
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278
Query: 438 LKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGG--KDKCLRIW 483
+ +W+++ +++ L GH D V + P +AS DK +++W
Sbjct: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 123 bits (309), Expect = 3e-28
Identities = 89/311 (28%), Positives = 150/311 (48%), Gaps = 34/311 (10%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
+CT L GH+EAV SV FSP G++LAS S D + W T GH + ++W
Sbjct: 34 KCT--LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91
Query: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
S D +L S + + LWD +GK + +TL GHS ++ ++ NP + S S
Sbjct: 92 SSDSSRLVSASDDKTLKLWDVRSGKCL-KTLKGHSNYVFCCNF-----NPPSNLIISGSF 145
Query: 225 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL 283
D +V+IW+ G+C + L+ H+ V+ + + G L+ S S D ++W A G +TL
Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL 205
Query: 284 -------------QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERAL 330
+G ++ T L D L+ + + G E K
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATL--DNTLKLWDYSRGRCL---KTYTGHKNE-KYCIF 259
Query: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASA 390
+ +++ G+ +VSGS+D +++W+ + K+ + ++ GH ++ P ++ASA
Sbjct: 260 ANFSVTGGKW---IVSGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISAACHPTENLIASA 315
Query: 391 SF--DKSIKLW 399
+ DK+IKLW
Sbjct: 316 ALENDKTIKLW 326
Score = 106 bits (264), Expect = 5e-23
Identities = 76/265 (28%), Positives = 122/265 (46%), Gaps = 45/265 (16%)
Query: 221 SSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVL 279
SSS + S + + + L GHT++V+ +++ +G L S+S DR I +W A+DG
Sbjct: 16 SSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY 75
Query: 280 CRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQ 339
+TL GH ++ +A S+D +
Sbjct: 76 EKTLYGHNLEISDVAWSSDSS--------------------------------------- 96
Query: 340 GPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
RLVS SDD TL LW K L + GH + F+P S ++ S SFD+++K+W
Sbjct: 97 ---RLVSASDDKTLKLWD-VRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 400 DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD-VKAQKLAMDLPGHADE 458
+ +TGK L +L H V + ++ L+VSGS D ++WD Q L +
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPP 212
Query: 459 VYAVDWSPDGQRVASGGKDKCLRIW 483
V V +SP+G+ + + D L++W
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLW 237
Score = 63.2 bits (152), Expect = 5e-10
Identities = 50/184 (27%), Positives = 85/184 (46%), Gaps = 25/184 (13%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS-IS 163
+C +L HS+ V +V F+ +G + SGS D R WD ++ T + +S +
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVK 217
Query: 164 WSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKW---------ITGLSWEPLHANP 214
+SP+G+ + + + + LWD S G+ + +T GH +TG W
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCL-KTYTGHKNEKYCIFANFSVTGGKW------- 269
Query: 215 ECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSV-TCLRWGGDGLLYSAS--QDRTIKV 271
+ S S+D V IW+ + L GHT V + + L+ SA+ D+TIK+
Sbjct: 270 ----IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKL 325
Query: 272 WRAH 275
W ++
Sbjct: 326 WMSN 329
Score = 53.5 bits (127), Expect = 4e-07
Identities = 29/100 (29%), Positives = 49/100 (49%)
Query: 384 SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
+++ S+S ++S ++ + +L GH AV + +S + L S S+D + +W
Sbjct: 11 AQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA 70
Query: 444 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
K L GH E+ V WS D R+ S DK L++W
Sbjct: 71 YDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLW 110
Score = 37.0 bits (84), Expect = 0.040
Identities = 19/60 (31%), Positives = 35/60 (58%)
Query: 424 ADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
A ++L +S S++ + +V + L L GH + V +V +SP+G+ +AS D+ + IW
Sbjct: 9 AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 129 bits (324), Expect = 6e-30
Identities = 93/333 (27%), Positives = 149/333 (44%), Gaps = 50/333 (15%)
Query: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212
KGH+ + S+ SP+G++LA+ + ++LW+ + R + GH +T + + P H
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSP-HG 72
Query: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKV 271
N +AS+S+D +VR+W HT V + + DG L +AS+D++IKV
Sbjct: 73 N----LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKV 128
Query: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS 331
W + +L H HWV S D L
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRL------------------------------ 158
Query: 332 RYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASAS 391
+VS S+D T+ +W +K+ + + N V F+P +ASA
Sbjct: 159 ------------IVSCSEDKTIKIWDTT-NKQCVNNFSDSVGFANFVDFNPSGTCIASAG 205
Query: 392 FDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD 451
D+++K+WD R K L + H V I++ L++ SSD TLK+ D+ +L
Sbjct: 206 SDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 265
Query: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
L GH V+ V +S G+ ASGG D + +WR
Sbjct: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWR 298
Score = 112 bits (281), Expect = 6e-25
Identities = 89/375 (23%), Positives = 156/375 (41%), Gaps = 63/375 (16%)
Query: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170
+GH A+ S+ SP GK LA+ S DT + W+ + GH+ V S+ +SP G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
LAS ++ + LW P + A H+ + + + + + +++A++S+D S+++
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKA-HTAPVRSVDF-----SADGQFLATASEDKSIKV 128
Query: 231 WDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHW 289
W R L HT V C ++ DG L+ S S+D+TIK+W +
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT----------TNKQC 178
Query: 290 VNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSD 349
VN + S +A F P+ + S
Sbjct: 179 VNNFSDSVGFA-NFVDFNPSGTCI-------------------------------ASAGS 206
Query: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409
D T+ +W K L H +N + F P + +AS D ++K+ D G+ + +
Sbjct: 207 DQTVKVWD-VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 265
Query: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV-------------KAQKLAMDLPGHA 456
L+GH V+ +++S L SG +D+ + +W ++L D P H
Sbjct: 266 LQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHL 325
Query: 457 DEVYAVDWSPDGQRV 471
++Y P ++V
Sbjct: 326 LDIYPRTPHPHEEKV 340
Score = 92.8 bits (229), Expect = 6e-19
Identities = 66/231 (28%), Positives = 109/231 (47%), Gaps = 11/231 (4%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167
S + H+ V SV FS G++LA+ S D +++ W + + ++ H HWV +SPD
Sbjct: 96 SEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPD 155
Query: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
GR + S ++ I +WD +T KQ + + + + NP +AS+ D +
Sbjct: 156 GRLIVSCSEDKTIKIWD-TTNKQCVNNFSDSVGFANFVDF-----NPSGTCIASAGSDQT 209
Query: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGH 286
V++WD + + H+ V C+ + G L +AS D T+K+ +G L TLQGH
Sbjct: 210 VKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGH 269
Query: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337
V T++ S L F A + + EL + L++ NL R
Sbjct: 270 TGPVFTVSFSKGGEL----FASGGADTQVLLWRTNFDELHCKGLTKRNLKR 316
Score = 68.9 bits (167), Expect = 1e-11
Identities = 38/127 (29%), Positives = 63/127 (49%)
Query: 357 SPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAA 416
S ED GH+A I + SP+ + +A+AS+D + LW+ + GH
Sbjct: 3 SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDV 62
Query: 417 VYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGK 476
V + +S LL S S D T+++W + + H V +VD+S DGQ +A+ +
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 477 DKCLRIW 483
DK +++W
Sbjct: 123 DKSIKVW 129
Score = 53.5 bits (127), Expect = 4e-07
Identities = 28/81 (34%), Positives = 43/81 (53%)
Query: 103 VTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSI 162
V + + HS V ++F P+G YL + S D T++ DL +T +GH V ++
Sbjct: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV 276
Query: 163 SWSPDGRKLASGCKNGQILLW 183
S+S G ASG + Q+LLW
Sbjct: 277 SFSKGGELFASGGADTQVLLW 297
Score = 38.9 bits (89), Expect = 0.011
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 2/50 (4%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKG 154
R +L+GH+ V +V+FS G+ ASG DT V W + + H CKG
Sbjct: 261 RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELH--CKG 308
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 125 bits (313), Expect = 1e-28
Identities = 109/391 (27%), Positives = 156/391 (39%), Gaps = 74/391 (18%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
V S+ W+ DG LA G +G +W + + TL H I L W N +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKW-----NKK 287
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
YV S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG 347
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
+T QGH + VN + D G L
Sbjct: 348 CDHPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 373
Query: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
L S SDD TL +WS +D + + H I + +SP S +
Sbjct: 374 --------LASCSDDMTLKIWSMKQD-ACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIM 424
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 425 LASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Query: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
L G ++ V W+ G +V + D
Sbjct: 485 SLVHSYQG-TGGIFEVCWNARGDKVGASASD 514
Score = 109 bits (272), Expect = 6e-24
Identities = 93/354 (26%), Positives = 138/354 (38%), Gaps = 73/354 (20%)
Query: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL---------AGH----S 199
+GH V +W+P LASG + +W+ + G T GH +
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 200 KWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG- 258
K +T L W N + +A S DG RIW T G L H + L+W G
Sbjct: 236 KDVTSLDW-----NSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 259 LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDL 318
+ SA D+T +W AH G + H + AL D+
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFH----SAPALDVDW------------------- 326
Query: 319 QGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQV 378
Q S S D + + D P+ GH +N +
Sbjct: 327 --------------------QNNMTFASCSTDMCIHVCRLGCDH-PVKTFQGHTNEVNAI 365
Query: 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA---------DSRLL 429
+ P ++AS S D ++K+W + + L+ H +Y I WS S +L
Sbjct: 366 KWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIML 425
Query: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
S S DST+++WDV+ L H + VY+V +SPDG+ +ASG DK + IW
Sbjct: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 73.2 bits (178), Expect = 5e-13
Identities = 79/313 (25%), Positives = 113/313 (36%), Gaps = 74/313 (23%)
Query: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 175 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
H + VT L W DG LL S D ++W +G L TL H
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQH------------- 275
Query: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
+G + LK Y ++S D T +W A
Sbjct: 276 -------------------KGPIFALKWNKKGNY----------VLSAGVDKTTIIWD-A 305
Query: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
+ + H A V + ++ AS S D I + + + +GH V
Sbjct: 306 HTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNA 364
Query: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
I W LL S S D TLK+W +K DL H+ E+Y + WSP G
Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIM 424
Query: 471 VASGGKDKCLRIW 483
+AS D +R+W
Sbjct: 425 LASASFDSTVRLW 437
Score = 73.2 bits (178), Expect = 5e-13
Identities = 59/226 (26%), Positives = 86/226 (38%), Gaps = 47/226 (20%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 270 STLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 329
Query: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 389
Query: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
V L HSK I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 390 QDACV-HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTL 448
Query: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
H + V + + DG L S S D+ + +W G L + QG G
Sbjct: 449 MKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTG 494
Score = 67.4 bits (163), Expect = 3e-11
Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
C L+ HS+ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 393 CVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQ 452
Query: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 453 EPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV------HSYQGTGGIFE-VCWNARG 505
Query: 217 RYVASSSKDGSVRIWD 232
V +S+ DGSV + D
Sbjct: 506 DKVGASASDGSVCVLD 521
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 125 bits (313), Expect = 1e-28
Identities = 109/391 (27%), Positives = 156/391 (39%), Gaps = 74/391 (18%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
V S+ W+ DG LA G +G +W + + TL H I L W N +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKW-----NKK 287
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
YV S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG 347
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
+T QGH + VN + D G L
Sbjct: 348 CDHPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 373
Query: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
L S SDD TL +WS +D + + H I + +SP S +
Sbjct: 374 --------LASCSDDMTLKIWSMKQD-ACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIM 424
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 425 LASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Query: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
L G ++ V W+ G +V + D
Sbjct: 485 SLVHSYQG-TGGIFEVCWNARGDKVGASASD 514
Score = 109 bits (272), Expect = 6e-24
Identities = 93/354 (26%), Positives = 138/354 (38%), Gaps = 73/354 (20%)
Query: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL---------AGH----S 199
+GH V +W+P LASG + +W+ + G T GH +
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 200 KWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG- 258
K +T L W N + +A S DG RIW T G L H + L+W G
Sbjct: 236 KDVTSLDW-----NSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 259 LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDL 318
+ SA D+T +W AH G + H + AL D+
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFH----SAPALDVDW------------------- 326
Query: 319 QGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQV 378
Q S S D + + D P+ GH +N +
Sbjct: 327 --------------------QNNMTFASCSTDMCIHVCRLGCDH-PVKTFQGHTNEVNAI 365
Query: 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA---------DSRLL 429
+ P ++AS S D ++K+W + + L+ H +Y I WS S +L
Sbjct: 366 KWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIML 425
Query: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
S S DST+++WDV+ L H + VY+V +SPDG+ +ASG DK + IW
Sbjct: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 73.2 bits (178), Expect = 5e-13
Identities = 79/313 (25%), Positives = 113/313 (36%), Gaps = 74/313 (23%)
Query: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 175 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
H + VT L W DG LL S D ++W +G L TL H
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQH------------- 275
Query: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
+G + LK Y ++S D T +W A
Sbjct: 276 -------------------KGPIFALKWNKKGNY----------VLSAGVDKTTIIWD-A 305
Query: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
+ + H A V + ++ AS S D I + + + +GH V
Sbjct: 306 HTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNA 364
Query: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
I W LL S S D TLK+W +K DL H+ E+Y + WSP G
Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIM 424
Query: 471 VASGGKDKCLRIW 483
+AS D +R+W
Sbjct: 425 LASASFDSTVRLW 437
Score = 73.2 bits (178), Expect = 5e-13
Identities = 59/226 (26%), Positives = 86/226 (38%), Gaps = 47/226 (20%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 270 STLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 329
Query: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 389
Query: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
V L HSK I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 390 QDACV-HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTL 448
Query: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
H + V + + DG L S S D+ + +W G L + QG G
Sbjct: 449 MKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTG 494
Score = 67.4 bits (163), Expect = 3e-11
Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
C L+ HS+ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 393 CVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQ 452
Query: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 453 EPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV------HSYQGTGGIFE-VCWNARG 505
Query: 217 RYVASSSKDGSVRIWD 232
V +S+ DGSV + D
Sbjct: 506 DKVGASASDGSVCVLD 521
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 125 bits (313), Expect = 1e-28
Identities = 109/391 (27%), Positives = 156/391 (39%), Gaps = 74/391 (18%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 234
Query: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
V S+ W+ DG LA G +G +W + + TL H I L W N +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLGQHKGPIFALKW-----NKK 287
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
YV S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 288 GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLG 347
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
+T QGH + VN + D G L
Sbjct: 348 CDHPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 373
Query: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
L S SDD TL +WS +D + + H I + +SP S +
Sbjct: 374 --------LASCSDDMTLKIWSMKQD-ACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIM 424
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 425 LASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSG 484
Query: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
L G ++ V W+ G +V + D
Sbjct: 485 SLVHSYQG-TGGIFEVCWNARGDKVGASASD 514
Score = 109 bits (272), Expect = 6e-24
Identities = 93/354 (26%), Positives = 138/354 (38%), Gaps = 73/354 (20%)
Query: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL---------AGH----S 199
+GH V +W+P LASG + +W+ + G T GH +
Sbjct: 176 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235
Query: 200 KWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG- 258
K +T L W N + +A S DG RIW T G L H + L+W G
Sbjct: 236 KDVTSLDW-----NSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 259 LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDL 318
+ SA D+T +W AH G + H + AL D+
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFH----SAPALDVDW------------------- 326
Query: 319 QGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQV 378
Q S S D + + D P+ GH +N +
Sbjct: 327 --------------------QNNMTFASCSTDMCIHVCRLGCDH-PVKTFQGHTNEVNAI 365
Query: 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA---------DSRLL 429
+ P ++AS S D ++K+W + + L+ H +Y I WS S +L
Sbjct: 366 KWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIML 425
Query: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
S S DST+++WDV+ L H + VY+V +SPDG+ +ASG DK + IW
Sbjct: 426 ASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 73.2 bits (178), Expect = 5e-13
Identities = 79/313 (25%), Positives = 113/313 (36%), Gaps = 74/313 (23%)
Query: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 175 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229
Query: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
H + VT L W DG LL S D ++W +G L TL H
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQH------------- 275
Query: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
+G + LK Y ++S D T +W A
Sbjct: 276 -------------------KGPIFALKWNKKGNY----------VLSAGVDKTTIIWD-A 305
Query: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
+ + H A V + ++ AS S D I + + + +GH V
Sbjct: 306 HTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNA 364
Query: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
I W LL S S D TLK+W +K DL H+ E+Y + WSP G
Sbjct: 365 IKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIM 424
Query: 471 VASGGKDKCLRIW 483
+AS D +R+W
Sbjct: 425 LASASFDSTVRLW 437
Score = 73.2 bits (178), Expect = 5e-13
Identities = 59/226 (26%), Positives = 86/226 (38%), Gaps = 47/226 (20%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 270 STLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 329
Query: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 330 MTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 389
Query: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
V L HSK I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 390 QDACV-HDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTL 448
Query: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
H + V + + DG L S S D+ + +W G L + QG G
Sbjct: 449 MKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTG 494
Score = 67.4 bits (163), Expect = 3e-11
Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
C L+ HS+ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 393 CVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQ 452
Query: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 453 EPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLV------HSYQGTGGIFE-VCWNARG 505
Query: 217 RYVASSSKDGSVRIWD 232
V +S+ DGSV + D
Sbjct: 506 DKVGASASDGSVCVLD 521
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 124 bits (312), Expect = 1e-28
Identities = 105/391 (26%), Positives = 157/391 (40%), Gaps = 74/391 (18%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLS-TETPHFTCKGHRHW---------- 158
L GH V A++P LASGSGD+T R W+LS T T RH
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 159 ---VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
V S+ W+ +G LA+G +G +W + + TL H I L W N +
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIW--TKDGNLASTLGQHKGPIFALKW-----NKK 277
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
++ S+ D + IWD G ++ H+ + W + S S D I V +
Sbjct: 278 GNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLG 337
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
+T QGH + VN + D G+L
Sbjct: 338 QDRPIKTFQGHTNEVNAI---------------------KWDPTGNL------------- 363
Query: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD---------SRI 386
L S SDD TL +WS +D + + H I + +SP + +
Sbjct: 364 --------LASCSDDMTLKIWSMKQD-NCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLM 414
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
+ASASFD +++LWD G + +L H VY +A+S D R L SGS D + +W+ +
Sbjct: 415 LASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTG 474
Query: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
L G ++ V W+ G +V + D
Sbjct: 475 ALVHSYRG-TGGIFEVCWNAAGDKVGASASD 504
Score = 120 bits (301), Expect = 3e-27
Identities = 107/445 (24%), Positives = 171/445 (38%), Gaps = 85/445 (19%)
Query: 74 GKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASG- 132
G+ +ES ++ + D++ Q +R + + ++ + A + G+ A+G
Sbjct: 75 GRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGE 134
Query: 133 --------SGDTTVRFWDLSTETPH---FTCKGHRHWVLSISWSPDGRKLASGCKNGQIL 181
+ T + D E P +GH V +W+P LASG +
Sbjct: 135 ENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTAR 194
Query: 182 LWDPSTGKQVGRTL-------------AGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
+W+ S G T +K +T L W N E +A+ S DG
Sbjct: 195 IWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDW-----NSEGTLLATGSYDGFA 249
Query: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
RIW T G L H + L+W G + SA D+T +W AH G + H
Sbjct: 250 RIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFH- 307
Query: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
+ AL D+ Q S
Sbjct: 308 ---SAPALDVDW---------------------------------------QSNNTFASC 325
Query: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
S D + + +D+ P+ GH +N + + P ++AS S D ++K+W + +
Sbjct: 326 STDMCIHVCKLGQDR-PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCV 384
Query: 408 ASLRGHVAAVYQIAWSAD---------SRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE 458
L+ H +Y I WS + +L S S DST+++WDV L H +
Sbjct: 385 HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEP 444
Query: 459 VYAVDWSPDGQRVASGGKDKCLRIW 483
VY+V +SPDG+ +ASG DKC+ IW
Sbjct: 445 VYSVAFSPDGRYLASGSFDKCVHIW 469
Score = 69.7 bits (169), Expect = 6e-12
Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 25/185 (13%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
R + +GH+ V ++ + PTG LAS S D T++ W + + + H + +I W
Sbjct: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
Query: 165 SPDG---------RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
SP G LAS + + LWD G + TL H + + +++ +P+
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICI-HTLTKHQEPVYSVAF-----SPD 453
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
RY+AS S D V IW+T G G T + + W G AS A
Sbjct: 454 GRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGAS---------AS 503
Query: 276 DGVLC 280
DG +C
Sbjct: 504 DGSVC 508
Score = 66.2 bits (160), Expect = 6e-11
Identities = 47/136 (34%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
C L+ H++ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 383 CVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQ 442
Query: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
V S+++SPDGR LASG + + +W+ TG V HS TG +E + N
Sbjct: 443 EPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALV------HSYRGTGGIFE-VCWNAAG 495
Query: 217 RYVASSSKDGSVRIWD 232
V +S+ DGSV + D
Sbjct: 496 DKVGASASDGSVCVLD 511
Score = 55.1 bits (131), Expect = 1e-07
Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 16/91 (17%)
Query: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLA---------------MDLPG 454
LRGH + V+ AW+ S LL SGS DST ++W++ + D+P
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
+ D V ++DW+ +G +A+G D RIW +
Sbjct: 225 NKD-VTSLDWNSEGTLLATGSYDGFARIWTK 254
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 120 bits (301), Expect = 3e-27
Identities = 96/333 (28%), Positives = 151/333 (45%), Gaps = 58/333 (17%)
Query: 155 HRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANP 214
H V S ++SPDG+ L +G ++G + W+ +G+ + R L GH+ + + +P
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWR-LGGHTGPVKFCRF-----SP 73
Query: 215 ECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWR 273
+ AS+S D +VR+WD +C R+L GH +SV + + D L S D+ + +W
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 274 AHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRY 333
G + R L GH ++++ F P +VN
Sbjct: 134 VQSGQMLRLLVGHRD-----------SIQSSDFSP---TVNC------------------ 161
Query: 334 NLVRGQGPERLVSGSDDFTLFLW-----SPAEDKKPLTRMTGHQALINQVLFSPDSRIVA 388
L +GS D T+ +W +PA + L GH A I+ + +S S ++A
Sbjct: 162 ----------LATGSWDSTVHIWDLRMVTPAVSHQALE---GHSANISCLCYSA-SGLLA 207
Query: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448
S S+DK+I +W T L L+GHV V IA+S D L S +KVWD K
Sbjct: 208 SGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267
Query: 449 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLR 481
L G D + ++PDG+ + SG D+ R
Sbjct: 268 LETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 120 bits (301), Expect = 3e-27
Identities = 72/192 (37%), Positives = 103/192 (53%), Gaps = 9/192 (4%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
L GH+ V FSP G AS S D TVR WD++ KGH+ V ++S+SPD R
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSR 118
Query: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
+LASG + +++LWD +G Q+ R L GH I + +P +A+ S D +V
Sbjct: 119 QLASGGWDKRVMLWDVQSG-QMLRLLVGHRDSIQSSDF-----SPTVNCLATGSWDSTVH 172
Query: 230 IWD---TTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGH 286
IWD T + L GH+ +++CL + GLL S S D+TI +W+ L L+GH
Sbjct: 173 IWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGH 232
Query: 287 GHWVNTMALSTD 298
WV ++A S D
Sbjct: 233 VTWVKSIAFSPD 244
Score = 103 bits (256), Expect = 5e-22
Identities = 78/275 (28%), Positives = 121/275 (44%), Gaps = 48/275 (17%)
Query: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKV 271
+P+ + + + S+DG V W+T +G+ L GHT V R+ DG L+ SAS D T+++
Sbjct: 30 SPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRL 89
Query: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALS 331
W R L+GH V T++ S D
Sbjct: 90 WDVARAKCLRVLKGHQRSVETVSFSPD--------------------------------- 116
Query: 332 RYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASAS 391
+L SG D + LW + + L + GH+ I FSP +A+ S
Sbjct: 117 ---------SRQLASGGWDKRVMLWD-VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
Query: 392 FDKSIKLWDGRTGKYLAS---LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKL 448
+D ++ +WD R S L GH A + + +SA S LL SGS D T+ +W L
Sbjct: 167 WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA-SGLLASGSWDKTIHIWKPTTSSL 225
Query: 449 AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
+ L GH V ++ +SPD +AS G + +++W
Sbjct: 226 LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Score = 86.7 bits (213), Expect = 4e-17
Identities = 53/142 (37%), Positives = 78/142 (54%), Gaps = 5/142 (3%)
Query: 346 SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405
S S D T+ LW A K L + GHQ + V FSPDSR +AS +DK + LWD ++G+
Sbjct: 80 SASCDCTVRLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD---LPGHADEVYAV 462
L L GH ++ +S L +GS DST+ +WD++ A+ L GH+ + +
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 463 DWSPDGQRVASGGKDKCLRIWR 484
+S G +ASG DK + IW+
Sbjct: 199 CYSASG-LLASGSWDKTIHIWK 219
Score = 84.3 bits (207), Expect = 2e-16
Identities = 64/203 (31%), Positives = 91/203 (44%), Gaps = 15/203 (7%)
Query: 102 AVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS 161
A +C L+GH +V +V+FSP + LASG D V WD+ + GHR + S
Sbjct: 93 ARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS 152
Query: 162 ISWSPDGRKLASGCKNGQILLWD-----PSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
+SP LA+G + + +WD P+ Q L GHS I+ L +
Sbjct: 153 SDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQ---ALEGHSANISCLCYS------AS 203
Query: 217 RYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAH 275
+AS S D ++ IW T L GH V + + D L L SA R +KVW +
Sbjct: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
Query: 276 DGVLCRTLQGHGHWVNTMALSTD 298
G TL+G +T A + D
Sbjct: 264 TGKCLETLKGVLDVAHTCAFTPD 286
Score = 82.4 bits (202), Expect = 8e-16
Identities = 42/113 (37%), Positives = 61/113 (53%)
Query: 371 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLV 430
H +N FSPD +++ + S D + W+ R+G+ L L GH V +S D L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 431 SGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
S S D T+++WDV K L GH V V +SPD +++ASGG DK + +W
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
Score = 44.3 bits (103), Expect = 3e-04
Identities = 29/85 (34%), Positives = 42/85 (49%), Gaps = 8/85 (9%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
L+GH V S+AFSP +LAS V+ WD +T T KG + +++PDG+
Sbjct: 229 LKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGK 288
Query: 170 KLASGCKNGQILLWDPSTGKQVGRT 194
L SG + T +Q+ RT
Sbjct: 289 ILVSGAAD--------QTRRQISRT 305
Score = 32.7 bits (73), Expect = 0.76
Identities = 15/44 (34%), Positives = 26/44 (59%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETP 148
+C +L+G + + AF+P GK L SG+ D T R ++++P
Sbjct: 266 KCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQISRTSKSP 309
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 120 bits (300), Expect = 4e-27
Identities = 105/391 (26%), Positives = 157/391 (40%), Gaps = 74/391 (18%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
V S+ W+ +G LA+G +G +W + + TL H I L W N +
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIW--TEDGNLASTLGQHKGPIFALKW-----NRK 289
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
Y+ S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 349
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
+T QGH + VN + D G L
Sbjct: 350 CDRPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 375
Query: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
L S SDD TL +WS + + + + H I + +SP + +
Sbjct: 376 --------LASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 426
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 427 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 486
Query: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
L G ++ V W+ G +V + D
Sbjct: 487 NLVHSYRG-TGGIFEVCWNARGDKVGASASD 516
Score = 113 bits (283), Expect = 3e-25
Identities = 92/354 (25%), Positives = 140/354 (39%), Gaps = 73/354 (20%)
Query: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL---------AGH----S 199
+GH V +W+P LASG + +W+ + G T GH +
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237
Query: 200 KWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG- 258
K +T L W N +A+ S DG RIW T G L H + L+W G
Sbjct: 238 KDVTSLDW-----NTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGN 291
Query: 259 LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDL 318
+ SA D+T +W AH G + H + AL D+
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFH----SAPALDVDW------------------- 328
Query: 319 QGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQV 378
Q S S D + + D+ P+ GH +N +
Sbjct: 329 --------------------QNNTTFASCSTDMCIHVCRLGCDR-PVKTFQGHTNEVNAI 367
Query: 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA---------DSRLL 429
+ P ++AS S D ++K+W + + L+ H +Y I WS + +L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
S S DST+++WD++ L H + VY+V +SPDG+ +ASG DKC+ IW
Sbjct: 428 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481
Score = 73.6 bits (179), Expect = 4e-13
Identities = 79/313 (25%), Positives = 115/313 (36%), Gaps = 74/313 (23%)
Query: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 177 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 231
Query: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
H + VT L W +G LL + S D ++W DG L TL H
Sbjct: 232 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQH------------- 277
Query: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
+G + LK Y ++S D T +W A
Sbjct: 278 -------------------KGPIFALKWNRKGNY----------ILSAGVDKTTIIWD-A 307
Query: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
+ + H A V + ++ AS S D I + + + + +GH V
Sbjct: 308 HTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNA 366
Query: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
I W LL S S D TLK+W +K + DL H E+Y + WSP G
Sbjct: 367 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 426
Query: 471 VASGGKDKCLRIW 483
+AS D +R+W
Sbjct: 427 LASASFDSTVRLW 439
Score = 72.0 bits (175), Expect = 1e-12
Identities = 57/226 (25%), Positives = 87/226 (38%), Gaps = 47/226 (20%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 272 STLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 331
Query: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 332 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 391
Query: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
+ L H+K I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 392 QEVCI-HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL 450
Query: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
T H + V + + DG L S S D+ + +W G L + +G G
Sbjct: 451 TKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG 496
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
C L+ H++ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 395 CIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQ 454
Query: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 455 EPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV------HSYRGTGGIFE-VCWNARG 507
Query: 217 RYVASSSKDGSVRIWD 232
V +S+ DGSV + D
Sbjct: 508 DKVGASASDGSVCVLD 523
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 120 bits (300), Expect = 4e-27
Identities = 105/391 (26%), Positives = 157/391 (40%), Gaps = 74/391 (18%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236
Query: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
V S+ W+ +G LA+G +G +W + + TL H I L W N +
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIW--TEDGNLASTLGQHKGPIFALKW-----NRK 289
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
Y+ S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 349
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
+T QGH + VN + D G L
Sbjct: 350 CDRPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 375
Query: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
L S SDD TL +WS + + + + H I + +SP + +
Sbjct: 376 --------LASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 426
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 427 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 486
Query: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
L G ++ V W+ G +V + D
Sbjct: 487 NLVHSYRG-TGGIFEVCWNARGDKVGASASD 516
Score = 113 bits (283), Expect = 3e-25
Identities = 92/354 (25%), Positives = 140/354 (39%), Gaps = 73/354 (20%)
Query: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL---------AGH----S 199
+GH V +W+P LASG + +W+ + G T GH +
Sbjct: 178 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237
Query: 200 KWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG- 258
K +T L W N +A+ S DG RIW T G L H + L+W G
Sbjct: 238 KDVTSLDW-----NTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGN 291
Query: 259 LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDL 318
+ SA D+T +W AH G + H + AL D+
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFPFH----SAPALDVDW------------------- 328
Query: 319 QGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQV 378
Q S S D + + D+ P+ GH +N +
Sbjct: 329 --------------------QNNTTFASCSTDMCIHVCRLGCDR-PVKTFQGHTNEVNAI 367
Query: 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA---------DSRLL 429
+ P ++AS S D ++K+W + + L+ H +Y I WS + +L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
S S DST+++WD++ L H + VY+V +SPDG+ +ASG DKC+ IW
Sbjct: 428 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 481
Score = 73.6 bits (179), Expect = 4e-13
Identities = 79/313 (25%), Positives = 115/313 (36%), Gaps = 74/313 (23%)
Query: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 177 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 231
Query: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
H + VT L W +G LL + S D ++W DG L TL H
Sbjct: 232 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQH------------- 277
Query: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
+G + LK Y ++S D T +W A
Sbjct: 278 -------------------KGPIFALKWNRKGNY----------ILSAGVDKTTIIWD-A 307
Query: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
+ + H A V + ++ AS S D I + + + + +GH V
Sbjct: 308 HTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNA 366
Query: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
I W LL S S D TLK+W +K + DL H E+Y + WSP G
Sbjct: 367 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 426
Query: 471 VASGGKDKCLRIW 483
+AS D +R+W
Sbjct: 427 LASASFDSTVRLW 439
Score = 72.0 bits (175), Expect = 1e-12
Identities = 57/226 (25%), Positives = 87/226 (38%), Gaps = 47/226 (20%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 272 STLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 331
Query: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 332 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 391
Query: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
+ L H+K I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 392 QEVCI-HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL 450
Query: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
T H + V + + DG L S S D+ + +W G L + +G G
Sbjct: 451 TKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG 496
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
C L+ H++ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 395 CIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQ 454
Query: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 455 EPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV------HSYRGTGGIFE-VCWNARG 507
Query: 217 RYVASSSKDGSVRIWD 232
V +S+ DGSV + D
Sbjct: 508 DKVGASASDGSVCVLD 523
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 120 bits (300), Expect = 4e-27
Identities = 105/391 (26%), Positives = 157/391 (40%), Gaps = 74/391 (18%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
Query: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
V S+ W+ +G LA+G +G +W + + TL H I L W N +
Sbjct: 288 NKDVTSLDWNTNGTLLATGSYDGFARIW--TEDGNLASTLGQHKGPIFALKW-----NRK 340
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
Y+ S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 400
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
+T QGH + VN + D G L
Sbjct: 401 CDRPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 426
Query: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
L S SDD TL +WS + + + + H I + +SP + +
Sbjct: 427 --------LASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 477
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 478 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 537
Query: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
L G ++ V W+ G +V + D
Sbjct: 538 NLVHSYRG-TGGIFEVCWNARGDKVGASASD 567
Score = 113 bits (283), Expect = 3e-25
Identities = 92/354 (25%), Positives = 140/354 (39%), Gaps = 73/354 (20%)
Query: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL---------AGH----S 199
+GH V +W+P LASG + +W+ + G T GH +
Sbjct: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
Query: 200 KWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG- 258
K +T L W N +A+ S DG RIW T G L H + L+W G
Sbjct: 289 KDVTSLDW-----NTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGN 342
Query: 259 LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDL 318
+ SA D+T +W AH G + H + AL D+
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFH----SAPALDVDW------------------- 379
Query: 319 QGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQV 378
Q S S D + + D+ P+ GH +N +
Sbjct: 380 --------------------QNNTTFASCSTDMCIHVCRLGCDR-PVKTFQGHTNEVNAI 418
Query: 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA---------DSRLL 429
+ P ++AS S D ++K+W + + L+ H +Y I WS + +L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
Query: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
S S DST+++WD++ L H + VY+V +SPDG+ +ASG DKC+ IW
Sbjct: 479 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
Score = 73.6 bits (179), Expect = 4e-13
Identities = 79/313 (25%), Positives = 115/313 (36%), Gaps = 74/313 (23%)
Query: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 228 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
Query: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
H + VT L W +G LL + S D ++W DG L TL H
Sbjct: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQH------------- 328
Query: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
+G + LK Y ++S D T +W A
Sbjct: 329 -------------------KGPIFALKWNRKGNY----------ILSAGVDKTTIIWD-A 358
Query: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
+ + H A V + ++ AS S D I + + + + +GH V
Sbjct: 359 HTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNA 417
Query: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
I W LL S S D TLK+W +K + DL H E+Y + WSP G
Sbjct: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 477
Query: 471 VASGGKDKCLRIW 483
+AS D +R+W
Sbjct: 478 LASASFDSTVRLW 490
Score = 72.0 bits (175), Expect = 1e-12
Identities = 57/226 (25%), Positives = 87/226 (38%), Gaps = 47/226 (20%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 323 STLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 382
Query: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 383 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 442
Query: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
+ L H+K I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 443 QEVCI-HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL 501
Query: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
T H + V + + DG L S S D+ + +W G L + +G G
Sbjct: 502 TKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG 547
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
C L+ H++ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 446 CIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQ 505
Query: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 506 EPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV------HSYRGTGGIFE-VCWNARG 558
Query: 217 RYVASSSKDGSVRIWD 232
V +S+ DGSV + D
Sbjct: 559 DKVGASASDGSVCVLD 574
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 120 bits (300), Expect = 4e-27
Identities = 105/391 (26%), Positives = 157/391 (40%), Gaps = 74/391 (18%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-------STETPHFTC---KGH---- 155
L GH V A++P LASGSGD+T R W+L ST+ C GH
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 287
Query: 156 RHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPE 215
V S+ W+ +G LA+G +G +W + + TL H I L W N +
Sbjct: 288 NKDVTSLDWNTNGTLLATGSYDGFARIW--TEDGNLASTLGQHKGPIFALKW-----NRK 340
Query: 216 CRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAH 275
Y+ S+ D + IWD G ++ H+ + W + S S D I V R
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 400
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNL 335
+T QGH + VN + D G L
Sbjct: 401 CDRPVKTFQGHTNEVNAI---------------------KWDPSGML------------- 426
Query: 336 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP---------DSRI 386
L S SDD TL +WS + + + + H I + +SP + +
Sbjct: 427 --------LASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 477
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
+ASASFD +++LWD G +L H VY +A+S D + L SGS D + +W+ ++
Sbjct: 478 LASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSG 537
Query: 447 KLAMDLPGHADEVYAVDWSPDGQRVASGGKD 477
L G ++ V W+ G +V + D
Sbjct: 538 NLVHSYRG-TGGIFEVCWNARGDKVGASASD 567
Score = 113 bits (283), Expect = 3e-25
Identities = 92/354 (25%), Positives = 140/354 (39%), Gaps = 73/354 (20%)
Query: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL---------AGH----S 199
+GH V +W+P LASG + +W+ + G T GH +
Sbjct: 229 RGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288
Query: 200 KWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG- 258
K +T L W N +A+ S DG RIW T G L H + L+W G
Sbjct: 289 KDVTSLDW-----NTNGTLLATGSYDGFARIW-TEDGNLASTLGQHKGPIFALKWNRKGN 342
Query: 259 LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDL 318
+ SA D+T +W AH G + H + AL D+
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFPFH----SAPALDVDW------------------- 379
Query: 319 QGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQV 378
Q S S D + + D+ P+ GH +N +
Sbjct: 380 --------------------QNNTTFASCSTDMCIHVCRLGCDR-PVKTFQGHTNEVNAI 418
Query: 379 LFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSA---------DSRLL 429
+ P ++AS S D ++K+W + + L+ H +Y I WS + +L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478
Query: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
S S DST+++WD++ L H + VY+V +SPDG+ +ASG DKC+ IW
Sbjct: 479 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIW 532
Score = 73.6 bits (179), Expect = 4e-13
Identities = 79/313 (25%), Positives = 115/313 (36%), Gaps = 74/313 (23%)
Query: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD----TTAGRCERILT------G 244
L GH + +W NP +AS S D + RIW+ + G + +L G
Sbjct: 228 LRGHESEVFICAW-----NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 282
Query: 245 H----TQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDY 299
H + VT L W +G LL + S D ++W DG L TL H
Sbjct: 283 HDVPSNKDVTSLDWNTNGTLLATGSYDGFARIW-TEDGNLASTLGQH------------- 328
Query: 300 ALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPA 359
+G + LK Y ++S D T +W A
Sbjct: 329 -------------------KGPIFALKWNRKGNY----------ILSAGVDKTTIIWD-A 358
Query: 360 EDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQ 419
+ + H A V + ++ AS S D I + + + + +GH V
Sbjct: 359 HTGEAKQQFPFHSAPALDVDWQNNTTF-ASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNA 417
Query: 420 IAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ---------R 470
I W LL S S D TLK+W +K + DL H E+Y + WSP G
Sbjct: 418 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIM 477
Query: 471 VASGGKDKCLRIW 483
+AS D +R+W
Sbjct: 478 LASASFDSTVRLW 490
Score = 72.0 bits (175), Expect = 1e-12
Identities = 57/226 (25%), Positives = 87/226 (38%), Gaps = 47/226 (20%)
Query: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD------------------------- 142
S+L H + ++ ++ G Y+ S D T WD
Sbjct: 323 STLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNN 382
Query: 143 ----------------LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPS 186
L + P T +GH + V +I W P G LAS + + +W
Sbjct: 383 TTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK 442
Query: 187 TGKQVGRTLAGHSKWITGLSWE---PLHANPECR-YVASSSKDGSVRIWDTTAGRCERIL 242
+ L H+K I + W P +NP +AS+S D +VR+WD G C L
Sbjct: 443 QEVCI-HDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL 501
Query: 243 TGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
T H + V + + DG L S S D+ + +W G L + +G G
Sbjct: 502 TKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG 547
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/136 (33%), Positives = 69/136 (50%), Gaps = 16/136 (11%)
Query: 106 CTSSLEGHSEAVISVAFSPTGK---------YLASGSGDTTVRFWDLSTETPHFTCKGHR 156
C L+ H++ + ++ +SPTG LAS S D+TVR WD+ T H+
Sbjct: 446 CIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQ 505
Query: 157 HWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216
V S+++SPDG+ LASG + + +W+ +G V HS TG +E + N
Sbjct: 506 EPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLV------HSYRGTGGIFE-VCWNARG 558
Query: 217 RYVASSSKDGSVRIWD 232
V +S+ DGSV + D
Sbjct: 559 DKVGASASDGSVCVLD 574
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 113 bits (283), Expect = 3e-25
Identities = 81/306 (26%), Positives = 131/306 (42%), Gaps = 50/306 (16%)
Query: 180 ILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCE 239
+++W + R GH +T +++ +P +AS S+D +VRIW
Sbjct: 5 LMVWHMKPQSRAYR-FTGHKDAVTCVNF-----SPSGHLLASGSRDKTVRIWVPNVKGES 58
Query: 240 RILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTD 298
+ HT +V + + DG + +AS D+T+KVW H +L H +WV S D
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
Query: 299 YALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSP 358
L +VS SDD T+ LW
Sbjct: 119 GRL------------------------------------------IVSASDDKTVKLWDK 136
Query: 359 AEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVY 418
+ ++ + H + V F P +A+A D ++K+WD RT + L + H AAV
Sbjct: 137 SS-RECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195
Query: 419 QIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDK 478
+++ L++ SSDSTLK+ D+ +L L GH V +S G+ ASGG D+
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE 255
Query: 479 CLRIWR 484
+ +W+
Sbjct: 256 QVMVWK 261
Score = 86.7 bits (213), Expect = 4e-17
Identities = 68/308 (22%), Positives = 122/308 (39%), Gaps = 50/308 (16%)
Query: 135 DTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRT 194
D+ + W + ++ + GH+ V +++SP G LASG ++ + +W P+ K
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNV-KGESTV 60
Query: 195 LAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRW 254
H+ + +H + + ++S D +V++W T + L+ H V C ++
Sbjct: 61 FRAHTATV-----RSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF 115
Query: 255 GGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASV 313
DG L+ SAS D+T+K+W + HG +V + F P+ +
Sbjct: 116 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYV-----------DFHPSGTCI 164
Query: 314 NPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQA 373
+ D T+ +W + L H A
Sbjct: 165 -------------------------------AAAGMDNTVKVWD-VRTHRLLQHYQLHSA 192
Query: 374 LINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGS 433
+N + F P + +AS D ++K+ D G+ L +L GH +A+S SG
Sbjct: 193 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 252
Query: 434 SDSTLKVW 441
SD + VW
Sbjct: 253 SDEQVMVW 260
Score = 84.3 bits (207), Expect = 2e-16
Identities = 72/289 (24%), Positives = 115/289 (39%), Gaps = 50/289 (17%)
Query: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
GH +AV V FSP+G LASGS D TVR W + + + H V S+ + DG+
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 172 ASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIW 231
+ + + +W K + +L+ H W+ + +P+ R + S+S D +V++W
Sbjct: 81 VTASDDKTVKVWATHRQKFL-FSLSQHINWVRCAKF-----SPDGRLIVSASDDKTVKLW 134
Query: 232 DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGHWV 290
D ++ C H VT + + G + +A D T+KVW L + Q H V
Sbjct: 135 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 194
Query: 291 NTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDD 350
N + +F P+ L++ S D
Sbjct: 195 NGL-----------SFHPS-------------------------------GNYLITASSD 212
Query: 351 FTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW 399
TL + E + L + GHQ V FS AS D+ + +W
Sbjct: 213 STLKILDLMEGRL-LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 82.8 bits (203), Expect = 6e-16
Identities = 42/134 (31%), Positives = 65/134 (48%), Gaps = 1/134 (0%)
Query: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409
D L +W + R TGH+ + V FSP ++AS S DK++++W
Sbjct: 2 DSCLMVWHMKPQSRAY-RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQ 469
R H A V + + +D + V+ S D T+KVW QK L H + V +SPDG+
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 470 RVASGGKDKCLRIW 483
+ S DK +++W
Sbjct: 121 LIVSASDDKTVKLW 134
Score = 71.6 bits (174), Expect = 1e-12
Identities = 49/169 (28%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST-ETPHFTCKGHRHWVLSISWSPD 167
SL H V FSP G+ + S S D TV+ WD S+ E H C+ H +V + + P
Sbjct: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-HGGFVTYVDFHPS 160
Query: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
G +A+ + + +WD T + + + HS + GLS+ +P Y+ ++S D +
Sbjct: 161 GTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSF-----HPSGNYLITASSDST 214
Query: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAH 275
++I D GR L GH T + + G + S D + VW+++
Sbjct: 215 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 6/126 (4%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C S H V V F P+G +A+ D TV+ WD+ T + H V +S+
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 200
Query: 166 PDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
P G L + + + + D G+ + TL GH T +++ + Y AS D
Sbjct: 201 PSGNYLITASSDSTLKILDLMEGRLL-YTLHGHQGPATTVAF-----SRTGEYFASGGSD 254
Query: 226 GSVRIW 231
V +W
Sbjct: 255 EQVMVW 260
Score = 36.6 bits (83), Expect = 0.053
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFW 141
R +L GH +VAFS TG+Y ASG D V W
Sbjct: 224 RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 113 bits (282), Expect = 4e-25
Identities = 81/272 (29%), Positives = 129/272 (47%), Gaps = 23/272 (8%)
Query: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG---DGLLYSASQDRTIKVWRAH 275
+ S S D ++++W G+C R L GHT V W D ++ S S DRT+KVW A
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNAE 331
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQ-GSLQELKERALSRYN 334
G TL GH V M L + +A++ D++ G + ++
Sbjct: 332 TGECIHTLYGHTSTVRCMHLHEKRVVSGSR----DATLRVWDIETGQCLHVLMGHVAAVR 387
Query: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDK 394
V+ G R+VSG+ DF + +W P E + L + GH + + F D V S S D
Sbjct: 388 CVQYDG-RRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 443
Query: 395 SIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG 454
SI++WD TG + +L GH + + +LVSG++DST+K+WD+K + L G
Sbjct: 444 SIRVWDVETGNCIHTLTGHQSLTSGM--ELKDNILVSGNADSTVKIWDIKTGQCLQTLQG 501
Query: 455 ---HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
H V + ++ + V + D +++W
Sbjct: 502 PNKHQSAVTCLQFNKN--FVITSSDDGTVKLW 531
Score = 112 bits (279), Expect = 1e-24
Identities = 93/348 (26%), Positives = 157/348 (45%), Gaps = 68/348 (19%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
L+GH + VI+ G + SGS D T++ W T T GH V WS R
Sbjct: 258 LKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMR 312
Query: 170 K--LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
+ SG + + +W+ TG+ + TL GH+ + + LH + V S S+D +
Sbjct: 313 DNIIISGSTDRTLKVWNAETGECI-HTLYGHTSTVRCMH---LHE----KRVVSGSRDAT 364
Query: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
+R+WD G+C +L GH +V C+++ G ++ S + D +KVW TLQGH
Sbjct: 365 LRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHT 423
Query: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
+ V Y+L+ +VSG
Sbjct: 424 NRV--------YSLQFDGI------------------------------------HVVSG 439
Query: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
S D ++ +W E + +TGHQ+L + + I+ S + D ++K+WD +TG+ L
Sbjct: 440 SLDTSIRVWD-VETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCL 496
Query: 408 ASLRG---HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
+L+G H +AV + + + +++ S D T+K+WD+K + +L
Sbjct: 497 QTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNL 542
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 113 bits (282), Expect = 4e-25
Identities = 81/272 (29%), Positives = 129/272 (47%), Gaps = 23/272 (8%)
Query: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG---DGLLYSASQDRTIKVWRAH 275
+ S S D ++++W G+C R L GHT V W D ++ S S DRT+KVW A
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNAE 449
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQ-GSLQELKERALSRYN 334
G TL GH V M L + +A++ D++ G + ++
Sbjct: 450 TGECIHTLYGHTSTVRCMHLHEKRVVSGSR----DATLRVWDIETGQCLHVLMGHVAAVR 505
Query: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDK 394
V+ G R+VSG+ DF + +W P E + L + GH + + F D V S S D
Sbjct: 506 CVQYDG-RRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
Query: 395 SIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG 454
SI++WD TG + +L GH + + +LVSG++DST+K+WD+K + L G
Sbjct: 562 SIRVWDVETGNCIHTLTGHQSLTSGM--ELKDNILVSGNADSTVKIWDIKTGQCLQTLQG 619
Query: 455 ---HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
H V + ++ + V + D +++W
Sbjct: 620 PNKHQSAVTCLQFNKN--FVITSSDDGTVKLW 649
Score = 112 bits (279), Expect = 1e-24
Identities = 93/348 (26%), Positives = 157/348 (45%), Gaps = 68/348 (19%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
L+GH + VI+ G + SGS D T++ W T T GH V WS R
Sbjct: 376 LKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMR 430
Query: 170 K--LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
+ SG + + +W+ TG+ + TL GH+ + + LH + V S S+D +
Sbjct: 431 DNIIISGSTDRTLKVWNAETGECI-HTLYGHTSTVRCMH---LHE----KRVVSGSRDAT 482
Query: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
+R+WD G+C +L GH +V C+++ G ++ S + D +KVW TLQGH
Sbjct: 483 LRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHT 541
Query: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
+ V Y+L+ +VSG
Sbjct: 542 NRV--------YSLQFDGI------------------------------------HVVSG 557
Query: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
S D ++ +W E + +TGHQ+L + + I+ S + D ++K+WD +TG+ L
Sbjct: 558 SLDTSIRVWD-VETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCL 614
Query: 408 ASLRG---HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
+L+G H +AV + + + +++ S D T+K+WD+K + +L
Sbjct: 615 QTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNL 660
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 113 bits (282), Expect = 4e-25
Identities = 81/272 (29%), Positives = 129/272 (47%), Gaps = 23/272 (8%)
Query: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGG---DGLLYSASQDRTIKVWRAH 275
+ S S D ++++W G+C R L GHT V W D ++ S S DRT+KVW A
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVWNAE 369
Query: 276 DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQ-GSLQELKERALSRYN 334
G TL GH V M L + +A++ D++ G + ++
Sbjct: 370 TGECIHTLYGHTSTVRCMHLHEKRVVSGSR----DATLRVWDIETGQCLHVLMGHVAAVR 425
Query: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDK 394
V+ G R+VSG+ DF + +W P E + L + GH + + F D V S S D
Sbjct: 426 CVQYDG-RRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 481
Query: 395 SIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG 454
SI++WD TG + +L GH + + +LVSG++DST+K+WD+K + L G
Sbjct: 482 SIRVWDVETGNCIHTLTGHQSLTSGM--ELKDNILVSGNADSTVKIWDIKTGQCLQTLQG 539
Query: 455 ---HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
H V + ++ + V + D +++W
Sbjct: 540 PNKHQSAVTCLQFNKN--FVITSSDDGTVKLW 569
Score = 112 bits (279), Expect = 1e-24
Identities = 93/348 (26%), Positives = 157/348 (45%), Gaps = 68/348 (19%)
Query: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169
L+GH + VI+ G + SGS D T++ W T T GH V WS R
Sbjct: 296 LKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMR 350
Query: 170 K--LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
+ SG + + +W+ TG+ + TL GH+ + + LH + V S S+D +
Sbjct: 351 DNIIISGSTDRTLKVWNAETGECI-HTLYGHTSTVRCMH---LHE----KRVVSGSRDAT 402
Query: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
+R+WD G+C +L GH +V C+++ G ++ S + D +KVW TLQGH
Sbjct: 403 LRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHT 461
Query: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
+ V Y+L+ +VSG
Sbjct: 462 NRV--------YSLQFDGI------------------------------------HVVSG 477
Query: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
S D ++ +W E + +TGHQ+L + + I+ S + D ++K+WD +TG+ L
Sbjct: 478 SLDTSIRVWD-VETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCL 534
Query: 408 ASLRG---HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
+L+G H +AV + + + +++ S D T+K+WD+K + +L
Sbjct: 535 QTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNL 580
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 111 bits (278), Expect = 1e-24
Identities = 89/339 (26%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 151 TCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPL 210
T +GH + ++ W D R L S ++G++++WD T +V + S W+ ++ P
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV-HAIPLRSSWVMTCAYAP- 107
Query: 211 HANPECRYVASSSKDGSVRIWD--TTAG--RCERILTGHTQSVTCLRWGGDGLLYSASQD 266
YVA D I++ T G R R L GHT ++C R+ D + ++S D
Sbjct: 108 ----SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163
Query: 267 RTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELK 326
T +W G T GH V +++L+ D L
Sbjct: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRL------------------------- 198
Query: 327 ERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRI 386
VSG+ D + LW E T TGH++ IN + F P+
Sbjct: 199 -----------------FVSGACDASAKLWDVREGMCRQT-FTGHESDINAICFFPNGNA 240
Query: 387 VASASFDKSIKLWDGRTGKYLASLRGH--VAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
A+ S D + +L+D R + L + + + +++S RLL++G D VWD
Sbjct: 241 FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 300
Query: 445 AQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
A L GH + V + + DG VA+G D L+IW
Sbjct: 301 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Score = 87.0 bits (214), Expect = 3e-17
Identities = 77/317 (24%), Positives = 137/317 (43%), Gaps = 35/317 (11%)
Query: 101 RAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVL 160
R R +L GH + ++ + + L S S D + WD T WV+
Sbjct: 42 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM 101
Query: 161 SISWSPDGRKLASGCKNGQILLWDPSTGK---QVGRTLAGHSKWITGLSWEPLHANPECR 217
+ +++P G +A G + +++ T + +V R LAGH+ +++ CR
Sbjct: 102 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC-----------CR 150
Query: 218 Y-----VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKV 271
+ + +SS D + +WD G+ TGHT V L D L+ S + D + K+
Sbjct: 151 FLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKL 210
Query: 272 WRAHDGVLCRTLQGHGHWVNTMA-LSTDYALRTGAFEPAEASVNPQDLQGSLQELKERAL 330
W +G+ +T GH +N + A TG+ +A+ DL+ QEL
Sbjct: 211 WDVREGMCRQTFTGHESDINAICFFPNGNAFATGS---DDATCRLFDLRAD-QEL--MTY 264
Query: 331 SRYNLVRG-------QGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD 383
S N++ G + L++G DDF +W + + + GH ++ + + D
Sbjct: 265 SHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV-LAGHDNRVSCLGVTDD 323
Query: 384 SRIVASASFDKSIKLWD 400
VA+ S+D +K+W+
Sbjct: 324 GMAVATGSWDSFLKIWN 340
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 111 bits (277), Expect = 2e-24
Identities = 73/267 (27%), Positives = 126/267 (47%), Gaps = 53/267 (19%)
Query: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278
+ S +D S++IWD T+ C ++LTGHT SV CL++ + ++ + S D T++VW + G
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY-DERVIVTGSSDSTVRVWDVNTGE 311
Query: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
+ TL H V + S
Sbjct: 312 VLNTLIHHNEAVLHLRFSNGL--------------------------------------- 332
Query: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396
+V+ S D ++ +W A R + GH+A +N V F D + + SAS D++I
Sbjct: 333 -----MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 385
Query: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
K+W T +++ +L GH + + + RL+VSGSSD+T+++WD++ L GH
Sbjct: 386 KVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 443
Query: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
+ V + + D +R+ SG D +++W
Sbjct: 444 ELVRCIRF--DNKRIVSGAYDGKIKVW 468
Score = 98.2 bits (243), Expect = 1e-20
Identities = 90/332 (27%), Positives = 141/332 (42%), Gaps = 78/332 (23%)
Query: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
D K+ SG ++ I +WD T + + L GH+ + L ++ R + + S D
Sbjct: 249 DDEKIISGLRDNSIKIWD-KTSLECLKVLTGHTGSVLCLQYDE-------RVIVTGSSDS 300
Query: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVW---RAHDGVLCRTL 283
+VR+WD G L H ++V LR+ +GL+ + S+DR+I VW A D L R L
Sbjct: 301 TVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRVL 359
Query: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPER 343
GH VN + Y
Sbjct: 360 VGHRAAVNVVDFDDKY-------------------------------------------- 375
Query: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403
+VS S D T+ +WS + + T + GH+ I + + R+V S S D +I+LWD
Sbjct: 376 IVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIEC 432
Query: 404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------ 451
G L L GH V I + D++ +VSG+ D +KVWD++A A+D
Sbjct: 433 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQA---ALDPRAPASTLCLRT 487
Query: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
L H+ V+ + + D ++ S D + IW
Sbjct: 488 LVEHSGRVFRLQF--DEFQIISSSHDDTILIW 517
Score = 92.4 bits (228), Expect = 8e-19
Identities = 68/262 (25%), Positives = 121/262 (46%), Gaps = 27/262 (10%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C L GH+ +V+ + + + + +GS D+TVR WD++T T H VL + +S
Sbjct: 272 CLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS 329
Query: 166 PDGRKLASGCKNGQILLWDPSTGKQV--GRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
+ + K+ I +WD ++ + R L GH + + ++ +Y+ S+S
Sbjct: 330 --NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 380
Query: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283
D ++++W T+ R L GH + + CL++ D L+ S S D TI++W G R L
Sbjct: 381 GDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 439
Query: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ-ELKERALSRYNLVRGQG-- 340
+GH V + + + +GA+ + + DLQ +L L LV G
Sbjct: 440 EGHEELVRCIRFD-NKRIVSGAY---DGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 495
Query: 341 ------PERLVSGSDDFTLFLW 356
+++S S D T+ +W
Sbjct: 496 FRLQFDEFQIISSSHDDTILIW 517
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 111 bits (277), Expect = 2e-24
Identities = 73/267 (27%), Positives = 126/267 (47%), Gaps = 53/267 (19%)
Query: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278
+ S +D S++IWD T+ C ++LTGHT SV CL++ + ++ + S D T++VW + G
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY-DERVIVTGSSDSTVRVWDVNTGE 277
Query: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
+ TL H V + S
Sbjct: 278 VLNTLIHHNEAVLHLRFSNGL--------------------------------------- 298
Query: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396
+V+ S D ++ +W A R + GH+A +N V F D + + SAS D++I
Sbjct: 299 -----MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 351
Query: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
K+W T +++ +L GH + + + RL+VSGSSD+T+++WD++ L GH
Sbjct: 352 KVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 409
Query: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
+ V + + D +R+ SG D +++W
Sbjct: 410 ELVRCIRF--DNKRIVSGAYDGKIKVW 434
Score = 98.2 bits (243), Expect = 1e-20
Identities = 90/332 (27%), Positives = 141/332 (42%), Gaps = 78/332 (23%)
Query: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
D K+ SG ++ I +WD T + + L GH+ + L ++ R + + S D
Sbjct: 215 DDEKIISGLRDNSIKIWD-KTSLECLKVLTGHTGSVLCLQYDE-------RVIVTGSSDS 266
Query: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVW---RAHDGVLCRTL 283
+VR+WD G L H ++V LR+ +GL+ + S+DR+I VW A D L R L
Sbjct: 267 TVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRVL 325
Query: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPER 343
GH VN + Y
Sbjct: 326 VGHRAAVNVVDFDDKY-------------------------------------------- 341
Query: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403
+VS S D T+ +WS + + T + GH+ I + + R+V S S D +I+LWD
Sbjct: 342 IVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIEC 398
Query: 404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------ 451
G L L GH V I + D++ +VSG+ D +KVWD++A A+D
Sbjct: 399 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQA---ALDPRAPASTLCLRT 453
Query: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
L H+ V+ + + D ++ S D + IW
Sbjct: 454 LVEHSGRVFRLQF--DEFQIISSSHDDTILIW 483
Score = 92.4 bits (228), Expect = 8e-19
Identities = 68/262 (25%), Positives = 121/262 (46%), Gaps = 27/262 (10%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C L GH+ +V+ + + + + +GS D+TVR WD++T T H VL + +S
Sbjct: 238 CLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS 295
Query: 166 PDGRKLASGCKNGQILLWDPSTGKQV--GRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
+ + K+ I +WD ++ + R L GH + + ++ +Y+ S+S
Sbjct: 296 --NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 346
Query: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283
D ++++W T+ R L GH + + CL++ D L+ S S D TI++W G R L
Sbjct: 347 GDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 405
Query: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ-ELKERALSRYNLVRGQG-- 340
+GH V + + + +GA+ + + DLQ +L L LV G
Sbjct: 406 EGHEELVRCIRFD-NKRIVSGAY---DGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 461
Query: 341 ------PERLVSGSDDFTLFLW 356
+++S S D T+ +W
Sbjct: 462 FRLQFDEFQIISSSHDDTILIW 483
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 111 bits (277), Expect = 2e-24
Identities = 73/267 (27%), Positives = 126/267 (47%), Gaps = 53/267 (19%)
Query: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278
+ S +D S++IWD T+ C ++LTGHT SV CL++ + ++ + S D T++VW + G
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY-DERVIVTGSSDSTVRVWDVNTGE 298
Query: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
+ TL H V + S
Sbjct: 299 VLNTLIHHNEAVLHLRFSNGL--------------------------------------- 319
Query: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396
+V+ S D ++ +W A R + GH+A +N V F D + + SAS D++I
Sbjct: 320 -----MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 372
Query: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
K+W T +++ +L GH + + + RL+VSGSSD+T+++WD++ L GH
Sbjct: 373 KVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 430
Query: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
+ V + + D +R+ SG D +++W
Sbjct: 431 ELVRCIRF--DNKRIVSGAYDGKIKVW 455
Score = 98.2 bits (243), Expect = 1e-20
Identities = 90/332 (27%), Positives = 141/332 (42%), Gaps = 78/332 (23%)
Query: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
D K+ SG ++ I +WD T + + L GH+ + L ++ R + + S D
Sbjct: 236 DDEKIISGLRDNSIKIWD-KTSLECLKVLTGHTGSVLCLQYDE-------RVIVTGSSDS 287
Query: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVW---RAHDGVLCRTL 283
+VR+WD G L H ++V LR+ +GL+ + S+DR+I VW A D L R L
Sbjct: 288 TVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRVL 346
Query: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPER 343
GH VN + Y
Sbjct: 347 VGHRAAVNVVDFDDKY-------------------------------------------- 362
Query: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403
+VS S D T+ +WS + + T + GH+ I + + R+V S S D +I+LWD
Sbjct: 363 IVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIEC 419
Query: 404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------ 451
G L L GH V I + D++ +VSG+ D +KVWD++A A+D
Sbjct: 420 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQA---ALDPRAPASTLCLRT 474
Query: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
L H+ V+ + + D ++ S D + IW
Sbjct: 475 LVEHSGRVFRLQF--DEFQIISSSHDDTILIW 504
Score = 92.4 bits (228), Expect = 8e-19
Identities = 68/262 (25%), Positives = 121/262 (46%), Gaps = 27/262 (10%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C L GH+ +V+ + + + + +GS D+TVR WD++T T H VL + +S
Sbjct: 259 CLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS 316
Query: 166 PDGRKLASGCKNGQILLWDPSTGKQV--GRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
+ + K+ I +WD ++ + R L GH + + ++ +Y+ S+S
Sbjct: 317 --NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 367
Query: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283
D ++++W T+ R L GH + + CL++ D L+ S S D TI++W G R L
Sbjct: 368 GDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 426
Query: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ-ELKERALSRYNLVRGQG-- 340
+GH V + + + +GA+ + + DLQ +L L LV G
Sbjct: 427 EGHEELVRCIRFD-NKRIVSGAY---DGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 482
Query: 341 ------PERLVSGSDDFTLFLW 356
+++S S D T+ +W
Sbjct: 483 FRLQFDEFQIISSSHDDTILIW 504
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 110 bits (276), Expect = 2e-24
Identities = 74/267 (27%), Positives = 129/267 (48%), Gaps = 53/267 (19%)
Query: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278
+ S +D +++IWD C+RILTGHT SV CL++ + ++ + S D T++VW + G
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY-DERVIITGSSDSTVRVWDVNTGE 338
Query: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
+ TL H EA ++ + G
Sbjct: 339 MLNTLIHH----------------------CEAVLHLRFNNG------------------ 358
Query: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396
+V+ S D ++ +W A R + GH+A +N V F D + + SAS D++I
Sbjct: 359 ----MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 412
Query: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
K+W+ T +++ +L GH + + + RL+VSGSSD+T+++WD++ L GH
Sbjct: 413 KVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 470
Query: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
+ V + + D +R+ SG D +++W
Sbjct: 471 ELVRCIRF--DNKRIVSGAYDGKIKVW 495
Score = 94.7 bits (234), Expect = 2e-19
Identities = 89/329 (27%), Positives = 143/329 (43%), Gaps = 72/329 (21%)
Query: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
D +K+ SG ++ I +WD +T + R L GH+ + L ++ R + + S D
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNT-LECKRILTGHTGSVLCLQYDE-------RVIITGSSDS 327
Query: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGH 286
+VR+WD G L H ++V LR+ +G++ + S+DR+I VW
Sbjct: 328 TVRVWDVNTGEMLNTLIHHCEAVLHLRF-NNGMMVTCSKDRSIAVW-------------- 372
Query: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVS 346
MA TD LR A+VN D + +VS
Sbjct: 373 -----DMASPTDITLRR-VLVGHRAAVNVVDFD---------------------DKYIVS 405
Query: 347 GSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY 406
S D T+ +W+ + + T + GH+ I + + R+V S S D +I+LWD G
Sbjct: 406 ASGDRTIKVWNTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGAC 462
Query: 407 LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------LPG 454
L L GH V I + D++ +VSG+ D +KVWD+ A A+D L
Sbjct: 463 LRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVA---ALDPRAPAGTLCLRTLVE 517
Query: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
H+ V+ + + D ++ S D + IW
Sbjct: 518 HSGRVFRLQF--DEFQIVSSSHDDTILIW 544
Score = 91.7 bits (226), Expect = 1e-18
Identities = 86/326 (26%), Positives = 136/326 (41%), Gaps = 72/326 (22%)
Query: 129 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTG 188
+ SG D T++ WD +T GH VL + + D R + +G + + +WD +TG
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 337
Query: 189 KQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD---TTAGRCERILTGH 245
+ + TL H + + LH + + SKD S+ +WD T R+L GH
Sbjct: 338 EML-NTLIHHCEAV-------LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 389
Query: 246 TQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGA 305
+V + + D + SAS DRTIKVW RTL GH + +
Sbjct: 390 RAAVNVVDF-DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACL------------ 436
Query: 306 FEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPL 365
+ ++R +VSGS D T+ LW E L
Sbjct: 437 ------------------QYRDRL--------------VVSGSSDNTIRLWD-IECGACL 463
Query: 366 TRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--------GRTGKY-LASLRGHVAA 416
+ GH+ L+ + F D++ + S ++D IK+WD G L +L H
Sbjct: 464 RVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGR 521
Query: 417 VYQIAWSADSRLLVSGSSDSTLKVWD 442
V+++ + D +VS S D T+ +WD
Sbjct: 522 VFRLQF--DEFQIVSSSHDDTILIWD 545
Score = 89.4 bits (220), Expect = 7e-18
Identities = 72/272 (26%), Positives = 131/272 (48%), Gaps = 27/272 (9%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C L GH+ +V+ + + + + +GS D+TVR WD++T T H VL + +
Sbjct: 299 CKRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF- 355
Query: 166 PDGRKLASGCKNGQILLWDPS--TGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
+ + + K+ I +WD + T + R L GH + + ++ +Y+ S+S
Sbjct: 356 -NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 407
Query: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283
D ++++W+T+ R L GH + + CL++ D L+ S S D TI++W G R L
Sbjct: 408 GDRTIKVWNTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 466
Query: 284 QGHGHWVNTMALSTDYALRTGAFE------PAEASVNPQDLQGSLQELKERALSRYNLVR 337
+GH V + + + +GA++ A+++P+ G+L L+ + R
Sbjct: 467 EGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLC-LRTLVEHSGRVFR 524
Query: 338 GQGPE-RLVSGSDDFTLFLW----SPAEDKKP 364
Q E ++VS S D T+ +W PA +P
Sbjct: 525 LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEP 556
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 110 bits (276), Expect = 2e-24
Identities = 74/267 (27%), Positives = 129/267 (48%), Gaps = 53/267 (19%)
Query: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278
+ S +D +++IWD C+RILTGHT SV CL++ + ++ + S D T++VW + G
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY-DERVIITGSSDSTVRVWDVNTGE 374
Query: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
+ TL H EA ++ + G
Sbjct: 375 MLNTLIHH----------------------CEAVLHLRFNNG------------------ 394
Query: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396
+V+ S D ++ +W A R + GH+A +N V F D + + SAS D++I
Sbjct: 395 ----MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 448
Query: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
K+W+ T +++ +L GH + + + RL+VSGSSD+T+++WD++ L GH
Sbjct: 449 KVWNTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 506
Query: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
+ V + + D +R+ SG D +++W
Sbjct: 507 ELVRCIRF--DNKRIVSGAYDGKIKVW 531
Score = 94.7 bits (234), Expect = 2e-19
Identities = 89/329 (27%), Positives = 143/329 (43%), Gaps = 72/329 (21%)
Query: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
D +K+ SG ++ I +WD +T + R L GH+ + L ++ R + + S D
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNT-LECKRILTGHTGSVLCLQYDE-------RVIITGSSDS 363
Query: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGH 286
+VR+WD G L H ++V LR+ +G++ + S+DR+I VW
Sbjct: 364 TVRVWDVNTGEMLNTLIHHCEAVLHLRF-NNGMMVTCSKDRSIAVW-------------- 408
Query: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVS 346
MA TD LR A+VN D + +VS
Sbjct: 409 -----DMASPTDITLRR-VLVGHRAAVNVVDFD---------------------DKYIVS 441
Query: 347 GSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY 406
S D T+ +W+ + + T + GH+ I + + R+V S S D +I+LWD G
Sbjct: 442 ASGDRTIKVWNTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGAC 498
Query: 407 LASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------LPG 454
L L GH V I + D++ +VSG+ D +KVWD+ A A+D L
Sbjct: 499 LRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVA---ALDPRAPAGTLCLRTLVE 553
Query: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
H+ V+ + + D ++ S D + IW
Sbjct: 554 HSGRVFRLQF--DEFQIVSSSHDDTILIW 580
Score = 91.7 bits (226), Expect = 1e-18
Identities = 86/326 (26%), Positives = 136/326 (41%), Gaps = 72/326 (22%)
Query: 129 LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTG 188
+ SG D T++ WD +T GH VL + + D R + +G + + +WD +TG
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTG 373
Query: 189 KQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD---TTAGRCERILTGH 245
+ + TL H + + LH + + SKD S+ +WD T R+L GH
Sbjct: 374 EML-NTLIHHCEAV-------LHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGH 425
Query: 246 TQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGA 305
+V + + D + SAS DRTIKVW RTL GH + +
Sbjct: 426 RAAVNVVDF-DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACL------------ 472
Query: 306 FEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPL 365
+ ++R +VSGS D T+ LW E L
Sbjct: 473 ------------------QYRDRL--------------VVSGSSDNTIRLWD-IECGACL 499
Query: 366 TRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--------GRTGKY-LASLRGHVAA 416
+ GH+ L+ + F D++ + S ++D IK+WD G L +L H
Sbjct: 500 RVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGR 557
Query: 417 VYQIAWSADSRLLVSGSSDSTLKVWD 442
V+++ + D +VS S D T+ +WD
Sbjct: 558 VFRLQF--DEFQIVSSSHDDTILIWD 581
Score = 89.4 bits (220), Expect = 7e-18
Identities = 72/272 (26%), Positives = 131/272 (48%), Gaps = 27/272 (9%)
Query: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
C L GH+ +V+ + + + + +GS D+TVR WD++T T H VL + +
Sbjct: 335 CKRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF- 391
Query: 166 PDGRKLASGCKNGQILLWDPS--TGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
+ + + K+ I +WD + T + R L GH + + ++ +Y+ S+S
Sbjct: 392 -NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 443
Query: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283
D ++++W+T+ R L GH + + CL++ D L+ S S D TI++W G R L
Sbjct: 444 GDRTIKVWNTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 502
Query: 284 QGHGHWVNTMALSTDYALRTGAFE------PAEASVNPQDLQGSLQELKERALSRYNLVR 337
+GH V + + + +GA++ A+++P+ G+L L+ + R
Sbjct: 503 EGHEELVRCIRFD-NKRIVSGAYDGKIKVWDLVAALDPRAPAGTLC-LRTLVEHSGRVFR 560
Query: 338 GQGPE-RLVSGSDDFTLFLW----SPAEDKKP 364
Q E ++VS S D T+ +W PA +P
Sbjct: 561 LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEP 592
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 108 bits (269), Expect = 1e-23
Identities = 93/331 (28%), Positives = 141/331 (42%), Gaps = 44/331 (13%)
Query: 152 CKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLH 211
C HR + +S SPDG++L +G ++G LW + G Q L GH ++T E
Sbjct: 11 CADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADG-QCCALLQGHESYVTFCQLE--- 66
Query: 212 ANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKV 271
E + S+ D ++R WD G+C ++ GHT V + + L+S+S DRT +V
Sbjct: 67 --DEAAFTCSA--DCTIRRWDVLTGQCLQVYRGHTSIVNRI-LVANNQLFSSSYDRTARV 121
Query: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYAL-RTGAFEPAEASVNPQDLQGSLQELKERAL 330
W G + R +GH + V T+A S + L T E A A G L
Sbjct: 122 WSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAA--------GGL-------- 165
Query: 331 SRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASA 390
LV+GS D T +W A T + GH + ++ +
Sbjct: 166 -------------LVTGSTDGTAKVWQVASGCCHQT-LRGHTGAVLCLVLDTPGHTAFTG 211
Query: 391 SFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAM 450
S D +I+ WD +G+ L R H +V I +RL+ SGS+D T+K W +
Sbjct: 212 STDATIRAWDILSGEQLRVFREHRGSV--ICLELVNRLVYSGSADRTVKCWLADTGECVR 269
Query: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLR 481
H V A+ + + +G D C R
Sbjct: 270 TFTAHRRNVSALKY--HAGTLFTGSGDACAR 298
Score = 86.3 bits (212), Expect = 6e-17
Identities = 89/349 (25%), Positives = 149/349 (42%), Gaps = 36/349 (10%)
Query: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
H + ++ SP G+ L +GS D T R W + +GH +V +
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC 73
Query: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
S + I WD TG Q + GH+ + + L AN + + SSS D + R+W
Sbjct: 74 SA--DCTIRRWDVLTG-QCLQVYRGHTSIVNRI----LVANNQ---LFSSSYDRTARVWS 123
Query: 233 TTAGRCERILTGHTQSVTCLRW---------------GGDGLLYSASQDRTIKVWRAHDG 277
G+ R GH V L + GLL + S D T KVW+ G
Sbjct: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG 183
Query: 278 VLCRTLQGHGHWVNTMALST-DYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
+TL+GH V + L T + TG+ +A++ D+ S ++L+ R +++
Sbjct: 184 CCHQTLRGHTGAVLCLVLDTPGHTAFTGS---TDATIRAWDIL-SGEQLRVFREHRGSVI 239
Query: 337 RGQGPERLV-SGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKS 395
+ RLV SGS D T+ W A+ + + T H+ ++ + + + S D
Sbjct: 240 CLELVNRLVYSGSADRTVKCWL-ADTGECVRTFTAHRRNVSALKYHAGTLFTGSG--DAC 296
Query: 396 IKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
+ +D ++G+ RGH + I ++L + S D L++WDV+
Sbjct: 297 ARAFDAQSGELRRVFRGHTFIINCI--QVHGQVLYTASHDGALRLWDVR 343
Score = 73.6 bits (179), Expect = 4e-13
Identities = 67/251 (26%), Positives = 102/251 (40%), Gaps = 33/251 (13%)
Query: 99 RVRAVTRCTSSLE--GHSEAVISVAFSP--------------TGKYLASGSGDTTVRFWD 142
RV +V + S E GH V+++A+S G L +GS D T + W
Sbjct: 120 RVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
Query: 143 LSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWI 202
+++ H T +GH VL + G +G + I WD +G+Q+ R H +
Sbjct: 180 VASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQL-RVFREHRGSV 238
Query: 203 TGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYS 262
L R V S S D +V+ W G C R T H ++V+ L++ G L++
Sbjct: 239 ICLELVN-------RLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA-GTLFT 290
Query: 263 ASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL--------STDYALRTGAFEPAEASVN 314
S D + + A G L R +GH +N + + S D ALR +
Sbjct: 291 GSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPR 350
Query: 315 PQDLQGSLQEL 325
P SL L
Sbjct: 351 PPPPMRSLSRL 361
Score = 70.1 bits (170), Expect = 4e-12
Identities = 64/265 (24%), Positives = 108/265 (40%), Gaps = 26/265 (9%)
Query: 236 GRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMA 294
G R+ H + L DG L + S+D T ++W DG C LQGH +V
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
Query: 295 LSTDYALRTGAFEPAEASVNPQD-LQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTL 353
L + A A + ++ D L G ++ S N + +L S S D T
Sbjct: 65 LEDEAAFTCSA----DCTIRRWDVLTGQCLQVYRGHTSIVNRILVAN-NQLFSSSYDRTA 119
Query: 354 FLWSPAEDKKPLTR-MTGHQALINQVLFSPD--------------SRIVASASFDKSIKL 398
+WS DK ++R GH+ + + +S ++ + S D + K+
Sbjct: 120 RVWSV--DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKV 177
Query: 399 WDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADE 458
W +G +LRGH AV + +GS+D+T++ WD+ + + H
Sbjct: 178 WQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGS 237
Query: 459 VYAVDWSPDGQRVASGGKDKCLRIW 483
V ++ + V SG D+ ++ W
Sbjct: 238 VICLELV--NRLVYSGSADRTVKCW 260
Score = 30.4 bits (67), Expect = 3.8
Identities = 20/83 (24%), Positives = 33/83 (39%), Gaps = 2/83 (2%)
Query: 401 GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVY 460
G G L H + ++ S D + L++GS D T ++W + L GH E Y
Sbjct: 2 GGGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGH--ESY 59
Query: 461 AVDWSPDGQRVASGGKDKCLRIW 483
+ + + D +R W
Sbjct: 60 VTFCQLEDEAAFTCSADCTIRRW 82
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,327,978
Number of Sequences: 37866
Number of extensions: 853396
Number of successful extensions: 7396
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 300
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 1817
Number of HSP's gapped (non-prelim): 2648
length of query: 485
length of database: 18,247,518
effective HSP length: 106
effective length of query: 379
effective length of database: 14,233,722
effective search space: 5394580638
effective search space used: 5394580638
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.