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Search of human proteins with 61888896
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61888896 roundabout, axon guidance receptor, homolog 2
isoform ROBO2b [Homo sapiens]
(1378 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 2803 0.0
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 2764 0.0
gi|19743806 roundabout 1 isoform b [Homo sapiens] 1397 0.0
gi|4506569 roundabout 1 isoform a [Homo sapiens] 1397 0.0
gi|224994171 roundabout 1 isoform c [Homo sapiens] 1395 0.0
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 1394 0.0
gi|224994173 roundabout 1 isoform d [Homo sapiens] 1386 0.0
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 1385 0.0
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 1041 0.0
gi|157311649 neogenin homolog 1 [Homo sapiens] 236 9e-62
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 232 2e-60
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 228 2e-59
gi|119220552 sidekick 1 [Homo sapiens] 219 2e-56
gi|222352127 sidekick 2 [Homo sapiens] 218 2e-56
gi|118572606 hemicentin 1 [Homo sapiens] 213 8e-55
gi|75709184 contactin 3 [Homo sapiens] 211 3e-54
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 211 5e-54
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 209 1e-53
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 209 2e-53
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 206 1e-52
gi|109150416 peroxidasin [Homo sapiens] 206 2e-52
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 205 2e-52
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 205 3e-52
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 204 4e-52
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 203 8e-52
gi|4827022 contactin 2 precursor [Homo sapiens] 203 1e-51
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 200 7e-51
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 200 7e-51
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 2803 bits (7266), Expect = 0.0
Identities = 1378/1378 (100%), Positives = 1378/1378 (100%)
Query: 1 MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTP 60
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTP
Sbjct: 1 MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTP 60
Query: 61 TIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAV 120
TIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAV
Sbjct: 61 TIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAV 120
Query: 121 SRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEER 180
SRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEER
Sbjct: 121 SRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEER 180
Query: 181 ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEE 240
ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEE
Sbjct: 181 ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEE 240
Query: 241 AVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 300
AVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG
Sbjct: 241 AVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 300
Query: 301 KMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQ 360
KMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQ
Sbjct: 301 KMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQ 360
Query: 361 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 420
PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII
Sbjct: 361 PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII 420
Query: 421 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480
LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI
Sbjct: 421 LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480
Query: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540
SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL
Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540
Query: 541 SWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINP 600
SWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINP
Sbjct: 541 SWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINP 600
Query: 601 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR 660
QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR
Sbjct: 601 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR 660
Query: 661 QPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQ 720
QPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQ
Sbjct: 661 QPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQ 720
Query: 721 GMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCL 780
GMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCL
Sbjct: 721 GMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCL 780
Query: 781 GNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVV 840
GNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVV
Sbjct: 781 GNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVV 840
Query: 841 ITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRG 900
ITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRG
Sbjct: 841 ITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRG 900
Query: 901 DGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQ 960
DGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQ
Sbjct: 901 DGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQ 960
Query: 961 GDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQW 1020
GDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQW
Sbjct: 961 GDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQW 1020
Query: 1021 KSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQ 1080
KSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQ
Sbjct: 1021 KSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQ 1080
Query: 1081 PLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASS 1140
PLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASS
Sbjct: 1081 PLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASS 1140
Query: 1141 PAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPP 1200
PAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPP
Sbjct: 1141 PAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPP 1200
Query: 1201 LGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSS 1260
LGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSS
Sbjct: 1201 LGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSS 1260
Query: 1261 QRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSK 1320
QRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSK
Sbjct: 1261 QRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSK 1320
Query: 1321 PSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL 1378
PSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL
Sbjct: 1321 PSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL 1378
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 2764 bits (7165), Expect = 0.0
Identities = 1358/1358 (100%), Positives = 1358/1358 (100%)
Query: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS
Sbjct: 37 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 96
Query: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT
Sbjct: 97 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 156
Query: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM
Sbjct: 157 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 216
Query: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 276
Query: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP
Sbjct: 277 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 336
Query: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN
Sbjct: 337 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 396
Query: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 440
IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK
Sbjct: 397 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 456
Query: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 500
ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS
Sbjct: 457 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 516
Query: 501 AVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAF 560
AVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAF
Sbjct: 517 AVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAF 576
Query: 561 SQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 620
SQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP
Sbjct: 577 SQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 636
Query: 621 PAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQA 680
PAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQA
Sbjct: 637 PAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQA 696
Query: 681 TSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPP 740
TSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPP
Sbjct: 697 TSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPP 756
Query: 741 QSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVI 800
QSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVI
Sbjct: 757 QSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVI 816
Query: 801 IGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPA 860
IGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPA
Sbjct: 817 IGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPA 876
Query: 861 FIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPS 920
FIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPS
Sbjct: 877 FIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPS 936
Query: 921 YPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFT 980
YPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFT
Sbjct: 937 YPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFT 996
Query: 981 TKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQ 1040
TKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQ
Sbjct: 997 TKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQ 1056
Query: 1041 NKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYD 1100
NKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYD
Sbjct: 1057 NKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYD 1116
Query: 1101 SDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREE 1160
SDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREE
Sbjct: 1117 SDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREE 1176
Query: 1161 MQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDD 1220
MQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDD
Sbjct: 1177 MQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDD 1236
Query: 1221 ADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALS 1280
ADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALS
Sbjct: 1237 ADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALS 1296
Query: 1281 QSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGS 1340
QSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGS
Sbjct: 1297 QSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGS 1356
Query: 1341 TGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL 1378
TGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL
Sbjct: 1357 TGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL 1394
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 1397 bits (3615), Expect = 0.0
Identities = 762/1462 (52%), Positives = 949/1462 (64%), Gaps = 170/1462 (11%)
Query: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 19 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
Query: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FVV+P
Sbjct: 259 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 318
Query: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
RDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLTITN
Sbjct: 319 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 378
Query: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 440
+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L C
Sbjct: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 438
Query: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 500
ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE +WS
Sbjct: 439 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 498
Query: 501 AVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIE 558
A ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++YIIE
Sbjct: 499 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 558
Query: 559 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDI 618
AFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+TQD+
Sbjct: 559 AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDV 618
Query: 619 SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGL 678
P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 619 LPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 678
Query: 679 QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSA 738
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEAPSA
Sbjct: 679 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 738
Query: 739 PPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRS 798
PPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD + S
Sbjct: 739 PPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 797
Query: 799 VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQ 858
V+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DVVKQ
Sbjct: 798 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 857
Query: 859 PAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA-------------VTFQRGDGGL 904
PAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG G
Sbjct: 858 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRG-GEA 916
Query: 905 MSNGSRPGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDV 953
+S+G RPGLLN +P + PWLAD+WP T N NS N D
Sbjct: 917 VSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADC 976
Query: 954 LPPVPGQGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYAT 999
+ Q D +T ML + +Y +D + K ++NS + Q TPYAT
Sbjct: 977 IANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYAT 1036
Query: 1000 TQILH---SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------- 1042
TQ++ SN+++ + D + WK QQK ++ Y++ +QNK
Sbjct: 1037 TQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPT 1096
Query: 1043 --------GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPL 1082
N GG KK + K K G WA++ LPPPP P
Sbjct: 1097 IPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPP 1155
Query: 1083 PGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP 1141
P + E Y + E+ YD + CP P + YL Q DEL EE+D+R PTPPVRG ASSP
Sbjct: 1156 PHSNSEEYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSP 1211
Query: 1142 -AISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQP 1196
A+S+ QSTATLTPSP+EE+QPMLQ D ++T H+Q QP P
Sbjct: 1212 AAVSYSHQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSP 1259
Query: 1197 PVPP--------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSS 1244
P PP GY+SG L+SD++TD +D+AD E ++ R LR L+QTP SS
Sbjct: 1260 PPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASS 1319
Query: 1245 MDNLDSSVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------- 1280
+ +L+SSVTG SS R +S F TD++ + A++
Sbjct: 1320 VGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKV 1379
Query: 1281 ---------------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMT 1310
SQ PRPT K ++ QP RRE T
Sbjct: 1380 ARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYT 1438
Query: 1311 DEEALVPYSKPSFPSPGGHSSS 1332
D+ P P+ SP S +
Sbjct: 1439 DDLPPPPVPPPAIKSPTAQSKT 1460
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1442 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1491
Query: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1492 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1543
Query: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1544 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1595
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 1397 bits (3615), Expect = 0.0
Identities = 762/1462 (52%), Positives = 949/1462 (64%), Gaps = 170/1462 (11%)
Query: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 58 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 117
Query: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
Query: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237
Query: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 297
Query: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FVV+P
Sbjct: 298 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 357
Query: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
RDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLTITN
Sbjct: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 417
Query: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 440
+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L C
Sbjct: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 477
Query: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 500
ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE +WS
Sbjct: 478 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 537
Query: 501 AVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIE 558
A ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++YIIE
Sbjct: 538 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597
Query: 559 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDI 618
AFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+TQD+
Sbjct: 598 AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDV 657
Query: 619 SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGL 678
P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 658 LPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 717
Query: 679 QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSA 738
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEAPSA
Sbjct: 718 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 777
Query: 739 PPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRS 798
PPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD + S
Sbjct: 778 PPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 836
Query: 799 VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQ 858
V+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DVVKQ
Sbjct: 837 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 896
Query: 859 PAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA-------------VTFQRGDGGL 904
PAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG G
Sbjct: 897 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRG-GEA 955
Query: 905 MSNGSRPGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDV 953
+S+G RPGLLN +P + PWLAD+WP T N NS N D
Sbjct: 956 VSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADC 1015
Query: 954 LPPVPGQGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYAT 999
+ Q D +T ML + +Y +D + K ++NS + Q TPYAT
Sbjct: 1016 IANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYAT 1075
Query: 1000 TQILH---SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------- 1042
TQ++ SN+++ + D + WK QQK ++ Y++ +QNK
Sbjct: 1076 TQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPT 1135
Query: 1043 --------GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPL 1082
N GG KK + K K G WA++ LPPPP P
Sbjct: 1136 IPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPP 1194
Query: 1083 PGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP 1141
P + E Y + E+ YD + CP P + YL Q DEL EE+D+R PTPPVRG ASSP
Sbjct: 1195 PHSNSEEYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSP 1250
Query: 1142 -AISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQP 1196
A+S+ QSTATLTPSP+EE+QPMLQ D ++T H+Q QP P
Sbjct: 1251 AAVSYSHQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSP 1298
Query: 1197 PVPP--------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSS 1244
P PP GY+SG L+SD++TD +D+AD E ++ R LR L+QTP SS
Sbjct: 1299 PPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASS 1358
Query: 1245 MDNLDSSVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------- 1280
+ +L+SSVTG SS R +S F TD++ + A++
Sbjct: 1359 VGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKV 1418
Query: 1281 ---------------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMT 1310
SQ PRPT K ++ QP RRE T
Sbjct: 1419 ARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYT 1477
Query: 1311 DEEALVPYSKPSFPSPGGHSSS 1332
D+ P P+ SP S +
Sbjct: 1478 DDLPPPPVPPPAIKSPTAQSKT 1499
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1481 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1530
Query: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1531 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1582
Query: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1583 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1634
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 1395 bits (3611), Expect = 0.0
Identities = 762/1456 (52%), Positives = 949/1456 (65%), Gaps = 164/1456 (11%)
Query: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 19 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
Query: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA---PPQFV 317
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FV
Sbjct: 259 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 318 VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
V+PRDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLT
Sbjct: 319 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 437
ITN+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L
Sbjct: 379 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 438
Query: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE
Sbjct: 439 SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
Query: 498 SWSAVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAY 555
+WSA ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++Y
Sbjct: 499 TWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY 558
Query: 556 IIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRT 615
IIEAFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+T
Sbjct: 559 IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 618
Query: 616 QDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQT 675
QD+ P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 619 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 678
Query: 676 SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 735
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEA
Sbjct: 679 GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 738
Query: 736 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 795
PSAPPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD +
Sbjct: 739 PSAPPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 796 IRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDV 855
SV+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DV
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
Query: 856 VKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA----VTFQRGDGGLMSNGSR 910
VKQPAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG G +S+G R
Sbjct: 858 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRG-GEAVSSGGR 916
Query: 911 PGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDVLPPVPG 959
PGLLN +P + PWLAD+WP T N NS N D +
Sbjct: 917 PGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNN 976
Query: 960 QGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYATTQILH- 1004
Q D +T ML + +Y +D + K ++NS + Q TPYATTQ++
Sbjct: 977 QLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQS 1036
Query: 1005 --SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------------- 1042
SN+++ + D + WK QQK ++ Y++ +QNK
Sbjct: 1037 NLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQS 1096
Query: 1043 --GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELE 1088
N GG KK + K K G WA++ LPPPP P P + E
Sbjct: 1097 YDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPPPHSNSE 1155
Query: 1089 HYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP-AISFG 1146
Y + E+ YD + CP P + YL Q DEL EE+D+R PTPPVRG ASSP A+S+
Sbjct: 1156 EYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSPAAVSYS 1211
Query: 1147 QQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQPPVPP-- 1200
QSTATLTPSP+EE+QPMLQ D ++T H+Q QP PP PP
Sbjct: 1212 HQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSPPPPPRP 1259
Query: 1201 ------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSSMDNLDS 1250
GY+SG L+SD++TD +D+AD E ++ R LR L+QTP SS+ +L+S
Sbjct: 1260 ISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLES 1319
Query: 1251 SVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------------- 1280
SVTG SS R +S F TD++ + A++
Sbjct: 1320 SVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQ 1379
Query: 1281 ---------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMTDEEALV 1316
SQ PRPT K ++ QP RRE TD+
Sbjct: 1380 DAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYTDDLPPP 1438
Query: 1317 PYSKPSFPSPGGHSSS 1332
P P+ SP S +
Sbjct: 1439 PVPPPAIKSPTAQSKT 1454
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1436 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1485
Query: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1486 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1537
Query: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1538 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1589
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 1394 bits (3608), Expect = 0.0
Identities = 763/1465 (52%), Positives = 950/1465 (64%), Gaps = 173/1465 (11%)
Query: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 19 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
Query: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA---PPQFV 317
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FV
Sbjct: 259 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 318 VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
V+PRDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLT
Sbjct: 319 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 437
ITN+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L
Sbjct: 379 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 438
Query: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE
Sbjct: 439 SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
Query: 498 SWSAVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAY 555
+WSA ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++Y
Sbjct: 499 TWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY 558
Query: 556 IIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRT 615
IIEAFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+T
Sbjct: 559 IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 618
Query: 616 QDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQT 675
QD+ P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 619 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 678
Query: 676 SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 735
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEA
Sbjct: 679 GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 738
Query: 736 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 795
PSAPPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD +
Sbjct: 739 PSAPPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 796 IRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDV 855
SV+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DV
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
Query: 856 VKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA-------------VTFQRGD 901
VKQPAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG
Sbjct: 858 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRG- 916
Query: 902 GGLMSNGSRPGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGR 950
G +S+G RPGLLN +P + PWLAD+WP T N NS N
Sbjct: 917 GEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRP 976
Query: 951 GDVLPPVPGQGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATP 996
D + Q D +T ML + +Y +D + K ++NS + Q TP
Sbjct: 977 ADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTP 1036
Query: 997 YATTQILH---SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK----------- 1042
YATTQ++ SN+++ + D + WK QQK ++ Y++ +QNK
Sbjct: 1037 YATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTV 1096
Query: 1043 -----------GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPV 1079
N GG KK + K K G WA++ LPPPP
Sbjct: 1097 PPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPA 1155
Query: 1080 QPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVA 1138
P P + E Y + E+ YD + CP P +TYL Q DEL EE+D+R PTPPVRG A
Sbjct: 1156 HPPPHSNSEEYNISVDES-YDQEMPCPVPPARTYLQQ---DELEEEEDERGPTPPVRGAA 1211
Query: 1139 SSP-AISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQP 1193
SSP A+S+ QSTATLTPSP+EE+QPMLQ D ++T H+Q QP
Sbjct: 1212 SSPAAVSYSHQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQP 1259
Query: 1194 PQPPVPP--------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTP 1241
PP PP GY+SG L+SD++TD +D+AD E ++ R LR L+QTP
Sbjct: 1260 VSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTP 1319
Query: 1242 GSSMDNLDSSVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS------- 1280
SS+ +L+SSVTG SS R +S F TD++ + A++
Sbjct: 1320 ASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAG 1379
Query: 1281 ------------------QSQRPRPT---------------KKHKGGRMDQQPALPHRRE 1307
SQ PRPT K ++ QP RRE
Sbjct: 1380 LKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRE 1438
Query: 1308 GMTDEEALVPYSKPSFPSPGGHSSS 1332
TD+ P P+ SP S +
Sbjct: 1439 TYTDDLPPPPVPPPAIKSPTAQSKT 1463
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1445 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1494
Query: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1495 GREVLGG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1546
Query: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1547 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1598
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 1386 bits (3587), Expect = 0.0
Identities = 757/1438 (52%), Positives = 937/1438 (65%), Gaps = 183/1438 (12%)
Query: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 19 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
Query: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA---PPQFV 317
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FV
Sbjct: 259 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 318 VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
V+PRDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLT
Sbjct: 319 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 437
ITN+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L
Sbjct: 379 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 438
Query: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE
Sbjct: 439 SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
Query: 498 SWSAVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAY 555
+WSA ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++Y
Sbjct: 499 TWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY 558
Query: 556 IIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRT 615
IIEAFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+T
Sbjct: 559 IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 618
Query: 616 QDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQT 675
QD+ P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 619 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 678
Query: 676 SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 735
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEA
Sbjct: 679 GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 738
Query: 736 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 795
PSAPPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD +
Sbjct: 739 PSAPPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 796 IRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDV 855
SV+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DV
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
Query: 856 VKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA----VTFQRGDGGLMSNGSR 910
VKQPAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG G +S+G R
Sbjct: 858 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRG-GEAVSSGGR 916
Query: 911 PGLLNAGDP-SYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLS 969
PGLLN +P + PWLAD+WP T NN N
Sbjct: 917 PGLLNISEPAAQPWLADTWPNTG---NNHND----------------------------- 944
Query: 970 DGAIYSSIDFTTKTSYNSSSQIT------QATPYATTQILH---SNSIHELAVDLPDPQW 1020
SI T + NS S +T Q TPYATTQ++ SN+++ + D + W
Sbjct: 945 -----CSISCCTAGNGNSDSNLTTYSRPGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHW 999
Query: 1021 KSSIQQKTDLMGFGYSLPDQNK----------------------GNNGGKGGKK------ 1052
K QQK ++ Y++ +QNK N GG
Sbjct: 1000 KPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSST 1059
Query: 1053 ------KKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCP 1106
KK + K K G WA++ LPPPP P P + E Y + E+ YD + CP
Sbjct: 1060 SGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPPPHSNSEEYNISVDES-YDQEMPCP 1117
Query: 1107 PLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP-AISFGQQSTATLTPSPREEMQPM 1164
P + YL Q DEL EE+D+R PTPPVRG ASSP A+S+ QSTATLTPSP+EE+QPM
Sbjct: 1118 VPPARMYLQQ---DELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPM 1174
Query: 1165 LQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQPPVPP--------LGYVSGALISDL 1212
LQ D ++T H+Q QP PP PP GY+SG L+SD+
Sbjct: 1175 LQ------------DCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDM 1222
Query: 1213 ETDV---ADDDADDEEEALEIPR-PLRALDQTPGSSMDNLDSSVTGKAFT---------- 1258
+TD +D+AD E ++ R LR L+QTP SS+ +L+SSVTG
Sbjct: 1223 DTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDN 1282
Query: 1259 -SSQRPRPTS---PFSTDSNTSAALS-------------------------QSQRPRPT- 1288
SS R +S F TD++ + A++ SQ PRPT
Sbjct: 1283 ISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTS 1342
Query: 1289 --------------KKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSS 1332
K ++ QP RRE TD+ P P+ SP S +
Sbjct: 1343 PVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYTDDLPPPPVPPPAIKSPTAQSKT 1399
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1381 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1430
Query: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1431 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1482
Query: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1483 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1534
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 1385 bits (3585), Expect = 0.0
Identities = 756/1441 (52%), Positives = 937/1441 (65%), Gaps = 178/1441 (12%)
Query: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 19 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
Query: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Query: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA---PPQFV 317
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FV
Sbjct: 259 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
Query: 318 VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
V+PRDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLT
Sbjct: 319 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 437
ITN+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L
Sbjct: 379 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 438
Query: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE
Sbjct: 439 SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
Query: 498 SWSAVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAY 555
+WSA ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++Y
Sbjct: 499 TWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY 558
Query: 556 IIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRT 615
IIEAFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+T
Sbjct: 559 IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 618
Query: 616 QDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQT 675
QD+ P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 619 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 678
Query: 676 SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 735
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEA
Sbjct: 679 GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 738
Query: 736 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 795
PSAPPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD +
Sbjct: 739 PSAPPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 796 IRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDV 855
SV+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DV
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
Query: 856 VKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA-------------VTFQRGD 901
VKQPAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG
Sbjct: 858 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRG- 916
Query: 902 GGLMSNGSRPGLLNAGDP-SYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQ 960
G +S+G RPGLLN +P + PWLAD+WP T N+ + GN G
Sbjct: 917 GEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGN-----------GN 965
Query: 961 GDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILH---SNSIHELAVDLPD 1017
D T S A + Q TPYATTQ++ SN+++ + D +
Sbjct: 966 SDSNLTTYSRPADW------------------QPTPYATTQLIQSNLSNNMNNGSGDSGE 1007
Query: 1018 PQWKSSIQQKTDLMGFGYSLPDQNK----------------------GNNGGKGGKK--- 1052
WK QQK ++ Y++ +QNK N GG
Sbjct: 1008 KHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRG 1067
Query: 1053 ---------KKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDS 1103
KK + K K G WA++ LPPPP P P + E Y + E+ YD +
Sbjct: 1068 SSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPPPHSNSEEYNISVDES-YDQEM 1125
Query: 1104 WCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP-AISFGQQSTATLTPSPREEM 1161
CP P +TYL Q DEL EE+D+R PTPPVRG ASSP A+S+ QSTATLTPSP+EE+
Sbjct: 1126 PCPVPPARTYLQQ---DELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEEL 1182
Query: 1162 QPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQPPVPP--------LGYVSGALI 1209
QPMLQ D ++T H+Q QP PP PP GY+SG L+
Sbjct: 1183 QPMLQ------------DCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLV 1230
Query: 1210 SDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSSMDNLDSSVTGKAFT------- 1258
SD++TD +D+AD E ++ R LR L+QTP SS+ +L+SSVTG
Sbjct: 1231 SDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASE 1290
Query: 1259 ----SSQRPRPTS---PFSTDSNTSAALS-------------------------QSQRPR 1286
SS R +S F TD++ + A++ SQ PR
Sbjct: 1291 EDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPR 1350
Query: 1287 PT---------------KKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSS 1331
PT K ++ QP RRE TD+ P P+ SP S
Sbjct: 1351 PTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYTDDLPPPPVPPPAIKSPTAQSK 1409
Query: 1332 S 1332
+
Sbjct: 1410 T 1410
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1392 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1441
Query: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1442 GREVLGG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1493
Query: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1494 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1545
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 1041 bits (2691), Expect = 0.0
Identities = 602/1381 (43%), Positives = 804/1381 (58%), Gaps = 121/1381 (8%)
Query: 19 VDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDP 78
++GSR+ ED PRIVE P D++VS+GEP TL C+AEGRP P IEWYK+G RV T ++DP
Sbjct: 52 LNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDP 111
Query: 79 RSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQN 138
R+HR+LLPSG+LFF RIVHGRR++PDEG Y CVARNYLG A SRNASLEVA+LRDDFRQ+
Sbjct: 112 RAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQS 171
Query: 139 PTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDA 198
P +VVVA GEPA+LEC PPRGHPEP++ W+KD R+ ++E RI+IRGGKLM+S+T KSDA
Sbjct: 172 PGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDA 231
Query: 199 GMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW 258
GMY CV +NM GER+S AE+ V ERP+FLRRP+NQVVL + V F C+V+GDP P +RW
Sbjct: 232 GMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRW 291
Query: 259 KKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 318
+K+D +LP GRY+I+ D++L I + DEGTY C+AEN VG+ EAS +L+V PPQ V
Sbjct: 292 RKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVT 351
Query: 319 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
+P+DQ+ A G +V F CETKGNP PA+FWQKEGSQ LLFP+Q QP R SVSP G L I
Sbjct: 352 QPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNI 411
Query: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLK 438
T +QR DAGYY+CQA++VAGSILAKA LE+ D PP+ILQGPANQTL + + L
Sbjct: 412 TAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLP 471
Query: 439 CKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETS 498
C+ TG+P P + W K+G G D + GTL I N++ D G Y+CVA SS+GE +
Sbjct: 472 CRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
Query: 499 WSAVLDVTES-GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYII 557
WS L + E G + + S PG PS+P VT++TKNS+TL+W+P ++Y+I
Sbjct: 532 WSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVI 591
Query: 558 EAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQD 617
EAFS + N+W+TVA+ V+ +TV GL+PNTIYLF+VRA+ GLS+PSP+S+PVRTQD
Sbjct: 592 EAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQD 651
Query: 618 ISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSG 677
SP D + Q+ L +V VRL P+VL P T+QV+WTVD Q +QG+RV +R +G
Sbjct: 652 SSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWR-VAG 710
Query: 678 LQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPS 737
+ SW LD + P+++S VL L G +IKV+ E G +S S T EEAPS
Sbjct: 711 PEG-GSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPS 769
Query: 738 APPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIR 797
PPQ V V G NS SI+VSW+PP P QNG+I EY+IWCLGNE+RFH+N++ R
Sbjct: 770 GPPQGVAVALGGDGNS-SITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWAR 828
Query: 798 SVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVI-TENNNSITEQITDVV 856
S ++ GL PG+ YR VAA+TSAGVGV S P + + ++ E + ++ V+
Sbjct: 829 SAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVL 888
Query: 857 KQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNY--------AVTFQRGDGGLMSNG 908
++PAF+AG G AC +L+G LYWRRK+RK LS+Y AV+F + GL
Sbjct: 889 REPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSE-GLSGAS 947
Query: 909 SRPGLLNAGDPSYPWLADSWPATSLPVNNSN-------SGPNEIGNFGRGDVLPPVPGQG 961
SRP + G Y WLADSWP S + S P+ + + Q
Sbjct: 948 SRPP-MGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQT 1006
Query: 962 DKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWK 1021
+ +G +YS+ID + Q H + DL W
Sbjct: 1007 ARGTAAPGEGPVYSTIDPAGE----------------ELQTFHGGFPQHPSGDL--GPWS 1048
Query: 1022 SSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPP--- 1078
Y+ P+ ++G++G KGGK K KP + W PPPP
Sbjct: 1049 Q------------YAPPEWSQGDSGAKGGKVKL---LGKPVQMPSLNWPEALPPPPPSCE 1093
Query: 1079 VQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVA 1138
+ L G E E+ E + + WCPP+P +++L + P R
Sbjct: 1094 LSCLEGPE------EELEGSSEPEEWCPPMPERSHLTE------PSSSGGCLVTPSRRET 1141
Query: 1139 SSPAISFGQQSTATLTPSPREEMQPML-QAHLDELTRAYQFDIAKQTWHIQSNNQPPQPP 1197
SP S+GQQSTATLTPSP + QP HL ++ R + P P
Sbjct: 1142 PSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPR-----------------RVPLGP 1184
Query: 1198 VPPLGYVSGALISDLETDVADDDADDEEEALEIPRPL-RALDQTPGSSMD---NLDSSVT 1253
PL VS ++ E A A P P PG + + +
Sbjct: 1185 SSPLS-VSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQ 1243
Query: 1254 GKAFTSSQRPR----------------PTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMD 1297
G ++P+ P P +++ + L + ++ + G
Sbjct: 1244 GPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERK 1303
Query: 1298 QQPALP--HRREGMTDEEALVPYSKPSFPS----------PGGHSSSGTASSKGSTGPRK 1345
A+P +R DEEA +PYS+PSF S G +SS G++SS+GS GP +
Sbjct: 1304 AVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGR 1363
Query: 1346 T 1346
+
Sbjct: 1364 S 1364
Score = 85.5 bits (210), Expect = 3e-16
Identities = 59/204 (28%), Positives = 94/204 (46%), Gaps = 18/204 (8%)
Query: 18 RVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERV---ETD 74
R + S PP++V P D + + GE C+ +G P P I W K+G +V +
Sbjct: 334 RAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQ 393
Query: 75 KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD 134
P + P G L + G D G YVC A + G +++ A LE+ D
Sbjct: 394 SLQPTGRFSVSPRGQLNITAVQRG-----DAGYYVCQAVSVAGSILAK-ALLEIKGASLD 447
Query: 135 -----FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDK--VRIDDKEERISIRGGK 187
Q P + + G L C+ G+P+P++ WKKD ++ DD + + ++ G
Sbjct: 448 GLPPVILQGPANQTLVLGSSVWLPCR-VTGNPQPSVRWKKDGQWLQGDDLQFK-TMANGT 505
Query: 188 LMISNTRKSDAGMYTCVGTNMVGE 211
L I+N ++ D G Y+CV + GE
Sbjct: 506 LYIANVQEMDMGFYSCVAKSSTGE 529
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 236 bits (603), Expect = 9e-62
Identities = 226/814 (27%), Positives = 339/814 (41%), Gaps = 79/814 (9%)
Query: 37 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIV 96
P D + +G LNC A P+P IEW KDG + DD R LLP GSLF +V
Sbjct: 59 PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
Query: 97 HGRRSKPDEGSYVCVAR-NYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQ 155
H + +KPDEG Y CVA LG +SR A L VA L F P V AG AIL C+
Sbjct: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
Query: 156 PPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 215
P + W++++ + + I + G L+ISN + D G+Y CV + + SD
Sbjct: 175 V-NADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
Query: 216 PAELTVFERP------TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG- 268
EL V P FL++P V + + V C G P PT++W K++ L
Sbjct: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
Query: 269 --RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA 326
R + +L I D GTY CIA+N +EA A LTV+A P+F+ +P +
Sbjct: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAH 353
Query: 327 QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA 386
+ + F CE G P P V W K G + P+ + +L + + +SD
Sbjct: 354 ESMDIVFECEVTGKPTPTVKWVKNGDMVI--------PSDYFKIVKEHNLQVLGLVKSDE 405
Query: 387 GYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLK-------C 439
G+Y C A G+ A AQL + + P + P + ++ T +K
Sbjct: 406 GFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRTPAS 464
Query: 440 KATGDPLPV-ISWLKEGFTFPGRDPRATIQEQGTLQ--IKNLRISDTGTYTCVATSSSGE 496
GD L + + KEG R+ G +Q I+NL + + +A + G
Sbjct: 465 DPHGDNLTYSVFYTKEGI---ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGS 521
Query: 497 TSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYI 556
SA L V LPGP + + S+T++W+ G Y
Sbjct: 522 GESSAPLRVETQPEV--------QLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK 573
Query: 557 IEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQ 616
+ + V + YT+ GL+ T Y F V A N G +P VRT
Sbjct: 574 LYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTP-DVAVRTL 629
Query: 617 DISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTS 676
P A + + +++ P T Q I GY++ YR+ S
Sbjct: 630 SDVPSAAPQNLSLEVRNSKSIMIHWQPPAPAT------------QNGQITGYKIRYRKAS 677
Query: 677 GLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTE--- 733
+ + + L + T+ S ++ L +G Y +V G ++ + T E
Sbjct: 678 --RKSDVTETLVS--GTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDL 733
Query: 734 EAPSAP--PQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-WCLGNETRFHINK 790
+ P P S+ V + TSI VSW PP++QN +++ Y I + +G+ I
Sbjct: 734 DETRVPEVPSSLHVRPL----VTSIVVSW--TPPENQNIVVRGYAIGYGIGSPHAQTIK- 786
Query: 791 TVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGV 824
VD R I L P Y + + A + G G+
Sbjct: 787 -VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
Score = 153 bits (386), Expect = 1e-36
Identities = 207/840 (24%), Positives = 333/840 (39%), Gaps = 117/840 (13%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
PR P V G LNC+ P + W ++ + + D + LPSG L
Sbjct: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-------FRQNPTDVV 143
G D G Y CV + G + +E+ +L D F + P+ +V
Sbjct: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
Query: 144 VAAGEPAILECQPPRGHPEPTIYWKKDKVRID--DKEERISIRGGKLMISNTRKSDAGMY 201
G+ +L C G P PTI W K++ +D E + + GG L IS+ + DAG Y
Sbjct: 260 RVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
Query: 202 TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW-KK 260
C+ N E AELTV +P FL++P N E + F C+V G P PTV+W K
Sbjct: 319 FCIADN-GNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
Query: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPP---Q 315
D +P + I ++ L++ + +DEG Y CIAEN VG +A A L + AP
Sbjct: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
Query: 316 FVVRPRDQI--VAQGRTVTFPCETKG------NPQPAVFWQKEG-----SQNLLFPNQPQ 362
PRD + + R + T N +VF+ KEG +N P + Q
Sbjct: 438 LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
Query: 363 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422
+TI N+ + + A GS + A L V + P + L
Sbjct: 498 -------------VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLP 539
Query: 423 GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPG--RDPRATIQEQGTLQIKNLRI 480
GPA L+ A ++W + + G ++ + E+GT + +++ +
Sbjct: 540 GPAPN---------LRAYAASPTSITVTW-ETPVSGNGEIQNYKLYYMEKGTDKEQDVDV 589
Query: 481 SDTGTYTCVATSSSGETSWSAVLDVTESGATISKN----YDLSDLP-GPPSKPQVTDVTK 535
S + +YT E S+ V+ + G +S LSD+P P +
Sbjct: 590 S-SHSYTINGLKKYTEYSF-RVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNS 647
Query: 536 NSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYT--VRGLRPNTIYLF 593
S+ + WQP P T + + S V T + + GL T Y F
Sbjct: 648 KSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNF 707
Query: 594 MVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQ 653
V A+ G P +D + + +D +V + + VR P+V T++
Sbjct: 708 RVAALTING---TGPATDWLSAETFE---SDLDETRVPEVPSSLHVR---PLV---TSIV 755
Query: 654 VTWT-VDRQPQFIQGYRVMY------RQTSGLQATSSWQNLDAKVPTERSAVLV----NL 702
V+WT + Q ++GY + Y QT + + ++ P+ + + N+
Sbjct: 756 VSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNV 815
Query: 703 KKGV-TYEIKV-RPY--FNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISV 758
+G+ YE V RP+ +E + + P PP V + + +I +
Sbjct: 816 GEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASIL---SHDTIRI 872
Query: 759 SW-DPPPPDHQNGIIQEYKIWCLGNETRFHIN---KTVDAAIRSVIIGGLFPGIQYRVEV 814
+W D P HQ I + + + + +T N K +A S ++ GL P Y V
Sbjct: 873 TWADNSLPKHQK--ITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSV 930
Score = 94.4 bits (233), Expect = 7e-19
Identities = 80/308 (25%), Positives = 126/308 (40%), Gaps = 28/308 (9%)
Query: 214 SDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL---PRGRY 270
S A + F FL P++ + + +V C +P P + WKKD L R
Sbjct: 42 SPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR 101
Query: 271 DIKDDYTLRIKKTMST-----DEGTYMCIA--ENRVGKMEASATLTVRAPPQFVVRPRDQ 323
+ D +L I + + DEG Y C+A E+ + +A L V P+F +P
Sbjct: 102 QLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161
Query: 324 IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR 383
V G CE + P V W++ QP + R P+G L I+N
Sbjct: 162 SVYAGNNAILNCEVNADLVPFVRWEQN--------RQPLLLDDRVIKLPSGMLVISNATE 213
Query: 384 SDAGYYICQALTVAGSILAKAQLEV-----TDVLTDRPPPIILQGPANQTLAVDGTALLK 438
D G Y C + G ++E+ +V++D + L+ P+ + +L
Sbjct: 214 GDGGLYRC-VVESGGPPKYSDEVELKVLPDPEVISDL---VFLKQPSPLVRVIGQDVVLP 269
Query: 439 CKATGDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C A+G P P I W+K E R + G+L+I ++ D GTY C+A + +
Sbjct: 270 CVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETI 329
Query: 498 SWSAVLDV 505
A L V
Sbjct: 330 EAQAELTV 337
Score = 32.7 bits (73), Expect = 2.5
Identities = 55/249 (22%), Positives = 91/249 (36%), Gaps = 26/249 (10%)
Query: 524 PPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVAN------HVKT 577
PP Q + ++ +++ ++W +LP I ++ +V AN + T
Sbjct: 856 PPVGVQASILSHDTIRITW---ADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATT 912
Query: 578 TLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDV 637
Y V GL+PNT+Y F V + S S M+ T ++ P + D V KE
Sbjct: 913 LSYLVTGLKPNTLYEFSVMVTKGRRSSTWS-MTAHGTTFELVPTSPPKDVTVVSKE---- 967
Query: 638 LVRLHNPVVLTPTTVQVTWTVDRQPQ-FIQGYRVMYRQTSGLQATSSWQNLDAKVPTERS 696
P T+ V W + I GY ++Y T W ++ V +
Sbjct: 968 ---------GKPKTIIVNWQPPSEANGKITGY-IIYYSTDVNAEIHDWV-IEPVVGNRLT 1016
Query: 697 AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 756
+ L Y K++ ++ G SE+ RT + S + G S
Sbjct: 1017 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLP 1076
Query: 757 SVSWDPPPP 765
+ D PP
Sbjct: 1077 DLGSDYKPP 1085
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 232 bits (591), Expect = 2e-60
Identities = 225/835 (26%), Positives = 358/835 (42%), Gaps = 94/835 (11%)
Query: 27 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
ED PRIV S+ +V+ GE +L C A+G P PT+ W D E + D R+++ +
Sbjct: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRD-GSHRTNQYTMS 522
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT-----D 141
G+ V G + + D G Y C ARN +G A + R + R P+ +
Sbjct: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSAEYQ--------ARINVRGPPSIRAMRN 573
Query: 142 VVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKS-DAGM 200
+ AG ++ C+ G+P +I W KD + + D ++ G L +++ +K D G
Sbjct: 574 ITAVAGRDTLINCR-VIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
Query: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPIN-QVVLEEEAVEFRCQV-QGDPQPTVRW 258
Y C + ++ + S + V + L +P + + C V GD + W
Sbjct: 633 YLC--SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITW 690
Query: 259 KKDDADLPRG---RYDIKDDY-TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
+KD + G + K+ +L+I G Y CIA N + L VR PP
Sbjct: 691 RKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPP 750
Query: 315 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGSQNLLFPNQ--PQQPNSRCSVS 371
+FVV+P +Q G+ C G P P V W+ +GS N P Q P R +
Sbjct: 751 RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGN---PQQYHPVPLTGRIQIL 807
Query: 372 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 431
P L I ++ D GYY+CQA G+ ++K+ LT + P +I P N T+A+
Sbjct: 808 PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF-----LTVKIPAMITSHP-NTTIAI 861
Query: 432 DGTAL-LKCKATGDPLPVISWLK-EGFTFPGRDPRATIQEQ-------GTLQIKNLRISD 482
G A L C A G+ +I W K + P R R I + TL++K D
Sbjct: 862 KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921
Query: 483 TGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW 542
+ ++C A +S GE L V E P P + ++ +V S+ L W
Sbjct: 922 SVFFSCHAINSYGEDRGLIQLTVQE--------------PPDPPELEIREVKARSMNLRW 967
Query: 543 QPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTL--YTVRGLRPNTIYLFMVRAINP 600
G + + IE ++S S ++ ++ T+ + L P ++Y + + N
Sbjct: 968 TQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
Query: 601 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTT---VQVTWT 657
G S+PS + T++ +P +D V L P T +QVTW
Sbjct: 1028 IGRSEPS-KELTISTEEAAPDGPPMD------------------VTLQPVTSQSIQVTWK 1068
Query: 658 VDR---QPQFIQGYRVMYRQTS-GLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVR 713
+ Q I+GY++ YR+ S G S + A +E L NLKK Y + V+
Sbjct: 1069 APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSE-VYTLDNLKKFAQYGVVVQ 1127
Query: 714 PYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQ 773
+ G S T E+ PS PP++V L++ S +SW PP NG+++
Sbjct: 1128 AFNRAGTGPSSSEINATTLEDVPSQPPENVRALSI---TSDVAVISWSEPPRSTLNGVLK 1184
Query: 774 EYKI--WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 826
Y++ W L + + + + V + G+ Y V+V A T AG GV+S
Sbjct: 1185 GYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRS 1239
Score = 149 bits (375), Expect = 2e-35
Identities = 195/839 (23%), Positives = 324/839 (38%), Gaps = 107/839 (12%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL-PSGS 89
P + ++ G T +NC+ G P +I+WYKD + P +HR ++ +G+
Sbjct: 565 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGT 618
Query: 90 LFFLRIVHGRRSKPDEGSYVC--VARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
L + G DEG Y+C + + L + S + +++V L F P + G
Sbjct: 619 LKLTDVQKGM----DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI----G 670
Query: 148 EPAILECQPPRGHPEPTIYWKKDK--------VRIDDKEERISIRGGKLMISNTRKSDAG 199
+ + C G I W+KD V I+ KE S L IS+ G
Sbjct: 671 QLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSS-----LQISSVSLKHNG 725
Query: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
YTC+ +N + +L V P F+ +P NQ + +A C V G P P V WK
Sbjct: 726 NYTCIASNAAATVSRE-RQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWK 784
Query: 260 KDDAD--------LP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK-MEASATLT 309
+P GR I + +L I+ + D G Y+C A N VG + S LT
Sbjct: 785 HAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLT 844
Query: 310 VRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS 369
V+ P P I +G C +G + W+K ++ P++ + +
Sbjct: 845 VKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEK--GDTVIDPDRVMR--YAIA 900
Query: 370 VSPTGDLTITNIQ-----RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 424
GD ++ ++ R D+ ++ C A+ G QL V + D P I +
Sbjct: 901 TKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEP-PDPPELEIREVK 959
Query: 425 ANQ-----TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLR 479
A T DG +++ SW F R+ TI + + +
Sbjct: 960 ARSMNLRWTQRFDGNSIITGFDIEYKNKSDSW---DFKQSTRNISPTINQANIVDLHPAS 1016
Query: 480 ISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVT 539
+ Y+ + G + S L ++ A GPP + VT S+
Sbjct: 1017 VYSIRMYSF---NKIGRSEPSKELTISTEEAAPD---------GPPMDVTLQPVTSQSIQ 1064
Query: 540 LSWQPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPNTIYLF 593
++W+ Y I S ++ Q +K T +YT+ L+ Y
Sbjct: 1065 VTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGV 1124
Query: 594 MVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQ 653
+V+A N G S + +D+ P+Q ++ + DV V
Sbjct: 1125 VVQAFNRAGTGPSSSEINATTLEDV--PSQPPENVRALSITSDVAV-------------- 1168
Query: 654 VTWTVDRQPQF---IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEI 710
++W+ + ++GYRV++ L W + T L ++K Y +
Sbjct: 1169 ISWSEPPRSTLNGVLKGYRVIFWS---LYVDGEWGEMQNITTTRERVELRGMEKFTNYSV 1225
Query: 711 KVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNG 770
+V Y G+ S ++T E+ P PP + + +++S+ VSW PP NG
Sbjct: 1226 QVLAYTQAGDGVRSSVLYIQTKEDVPG-PPAGIKAVPS---SASSVVVSW--LPPTKPNG 1279
Query: 771 IIQEYKIWCLGNETRFHINKTVDAAIRSVI--IGGLFPGIQYRVEVAASTSAGVGVKSE 827
+I++Y I+C + + + + I L G QY + VAA TSAG G SE
Sbjct: 1280 VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE 1338
Score = 139 bits (349), Expect = 2e-32
Identities = 135/491 (27%), Positives = 205/491 (41%), Gaps = 60/491 (12%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P I++ V G L C A G P P I W KDG LP+ S
Sbjct: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
Query: 91 FFLRI----VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA 146
+ RI + R++ D G+Y+C N G A + + + L P +
Sbjct: 332 WTKRITGLTISDLRTE-DSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGI 388
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG---GKLMISNTRKSDAGMYTC 203
G IL C G PE TI W ++ + +E ISIRG L+I++ +KS +G Y C
Sbjct: 389 GSTVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC 446
Query: 204 VGTNMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD 262
T + D A + + + P + +VV E C +G P PTV W DD
Sbjct: 447 FATRK-AQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDD 505
Query: 263 ADLPRGRYDIKDDYTLRIKKTMS---------TDEGTYMCIAENRVGKMEASATLTVRAP 313
+ R + YT+ T+S D G Y C A N VG E A + VR P
Sbjct: 506 EPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGP 565
Query: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
P + R+ GR C G P ++ W K+ LL P+ N R V
Sbjct: 566 PS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLLPD-----NHRQVVFEN 616
Query: 374 GDLTITNIQRS-DAGYYICQALTVAGSILAKAQLEVTDV--LTDRPPPIILQGPANQTLA 430
G L +T++Q+ D G Y+C S+L + QL ++ + + PP+I Q +
Sbjct: 617 GTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLI-QPFEFPPAS 668
Query: 431 VDGTALLKCKATGDPLPV-ISWLKEG-FTFPGRDPRATIQE-QGTLQIKNLRISDTGTYT 487
+ + C + +P+ I+W K+G G +E +LQI ++ + G YT
Sbjct: 669 IGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYT 728
Query: 488 CVATSSSGETS 498
C+A++++ S
Sbjct: 729 CIASNAAATVS 739
Score = 127 bits (319), Expect = 7e-29
Identities = 191/832 (22%), Positives = 317/832 (38%), Gaps = 102/832 (12%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
P + P + G L+C G P TI WY++ E V D+ +
Sbjct: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE--------AISIRG 425
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD---FRQNPTDVVVAA 146
L ++ K G+Y C A A + L D + ++ VV
Sbjct: 426 LSNETLLITSAQKSHSGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRI----DDKEERISIRGG----KLMISNTRKSDA 198
GE L C +G P PT+ W D I + + ++ G + ++ + D
Sbjct: 482 GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
Query: 199 GMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW 258
G+Y C N+VG + A + V P +R N + C+V G P +++W
Sbjct: 541 GVYRCTARNLVGSAEYQ-ARINV-RGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598
Query: 259 KKDDADLP-RGRYDIKDDYTLRIKKTM-STDEGTYMC-IAENRVGKMEASATLTVRAPPQ 315
KD LP R + ++ TL++ DEG Y+C + + S + V+ PP
Sbjct: 599 YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP- 657
Query: 316 FVVRPRDQIVAQ-GRTVTFPCETKGNPQP-AVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
+++P + A G+ + PC P + W+K+G ++ S+ +S
Sbjct: 658 -LIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDG--QVIISGSGVTIESKEFMS-- 712
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
L I+++ G Y C A A ++ + QL V R PP + P NQ
Sbjct: 713 -SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYGK 765
Query: 434 TALLKCKATGDPLPVISWL-KEGFTFPGR------DPRATIQEQGTLQIKNLRISDTGTY 486
+L C G P P + W +G P + R I +L I+++ D G Y
Sbjct: 766 AGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYY 825
Query: 487 TCVATSSSG-ETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 545
C A++ G + S S L V S + G + T + + + W+ G
Sbjct: 826 LCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG 885
Query: 546 TPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSD 605
P + ++ + ++ + V +TL R ++++ F AIN G +
Sbjct: 886 DTVIDPDR---VMRYAIATKDN----GDEVVSTLKLKPADRGDSVF-FSCHAINSYG--E 935
Query: 606 PSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQ-PQF 664
+ + PP + E+ +V R ++ + WT
Sbjct: 936 DRGLIQLTVQEPPDPP---------ELEIREVKAR----------SMNLRWTQRFDGNSI 976
Query: 665 IQGYRVMYRQTSGLQATSSW---QNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQG 721
I G+ + Y+ S SW Q+ PT A +V+L Y I++ + +
Sbjct: 977 ITGFDIEYKNKS-----DSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRS 1031
Query: 722 MDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI---- 777
S+ T+ T E AP PP VT+ V S SI V+W P + QNG+I+ Y+I
Sbjct: 1032 EPSKELTISTEEAAPDGPPMDVTLQPV---TSQSIQVTWKAPKKELQNGVIRGYQIGYRE 1088
Query: 778 ---WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 826
G + + T D+ + + + L QY V V A AG G S
Sbjct: 1089 NSPGSNGQYSIVEMKATGDSEVYT--LDNLKKFAQYGVVVQAFNRAGTGPSS 1138
Score = 124 bits (311), Expect = 6e-28
Identities = 130/491 (26%), Positives = 194/491 (39%), Gaps = 48/491 (9%)
Query: 40 VIVSKGEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHR----MLLPSGSLFFLR 94
V S + C A G P+ + WY G+ + H L P F
Sbjct: 95 VTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNS 154
Query: 95 IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
+H + Y C A N G+ S N ++ A+ R+ + D G A+ +C
Sbjct: 155 FIH-------DNDYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKC 206
Query: 155 QPPRGHPE--PTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDA-GMYTCVGTNMV-G 210
P E + W+KD V I + G L IS+ +K DA Y C+ + G
Sbjct: 207 LIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSG 266
Query: 211 E-RDSDPAELTVFER----PTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL 265
E R S+ A L+V + PT L +Q V VE C G P P +RW KD L
Sbjct: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL 326
Query: 266 PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 325
P K L I + D GTY+C N G EA+ L V P + P+
Sbjct: 327 PADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKT 386
Query: 326 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG----DLTITNI 381
G TV C G+P+ + W + + L+ P++ ++S G L IT+
Sbjct: 387 GIGSTVILSCALTGSPEFTIRWYR--NTELVLPDE--------AISIRGLSNETLLITSA 436
Query: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 441
Q+S +G Y C A A + A + + D P I+ + + + L C A
Sbjct: 437 QKSHSGAYQCFATRKAQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAA 491
Query: 442 TGDPLPVISWL--KEGFTFPG--RDPRATIQEQGTLQIKNL---RISDTGTYTCVATSSS 494
G P P ++W E G R + T+ + T+ N+ +I D G Y C A +
Sbjct: 492 KGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLV 551
Query: 495 GETSWSAVLDV 505
G + A ++V
Sbjct: 552 GSAEYQARINV 562
Score = 85.1 bits (209), Expect = 4e-16
Identities = 86/301 (28%), Positives = 127/301 (42%), Gaps = 34/301 (11%)
Query: 227 FLRRPINQVVLEEEA-VEFRCQVQGDPQPTVRWK----KDDADLPRGRYDIKDDYTLRIK 281
F+ + QV V C G P +RW D D+P R+ + + TL++
Sbjct: 87 FVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRH-VHANGTLQLY 145
Query: 282 KTMST------DEGTYMCIAENRVGKMEASATLTVRAP--PQFVVRPRDQIVAQGRTVTF 333
+ + Y C AEN GK+ S + V+A + VR DQ +G F
Sbjct: 146 PFSPSAFNSFIHDNDYFCTAENAAGKIR-SPNIRVKAVFREPYTVRVEDQRSMRGNVAVF 204
Query: 334 PCETKGNPQP---AVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA--GY 388
C + Q V W+K+ + P R ++ G L I+++Q+ DA Y
Sbjct: 205 KCLIPSSVQEYVSVVSWEKDTVSII--------PEHRFFITYHGGLYISDVQKEDALSTY 256
Query: 389 YICQALTVAGSILAK--AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 446
+G A+L VTD P IL G +Q + T L C A+G P+
Sbjct: 257 RCITKHKYSGETRQSNGARLSVTDPAESIPT--ILDGFHSQEVWAGHTVELPCTASGYPI 314
Query: 447 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVT 506
P I WLK+G P D R T + G L I +LR D+GTY C T++ G + +L V
Sbjct: 315 PAIRWLKDGRPLPA-DSRWTKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVI 372
Query: 507 E 507
+
Sbjct: 373 D 373
Score = 62.8 bits (151), Expect = 2e-09
Identities = 65/279 (23%), Positives = 104/279 (37%), Gaps = 43/279 (15%)
Query: 329 RTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 388
R T C + G+ QPA + + L + I ++ R
Sbjct: 1282 RKYTIFCSSPGSGQPAPSEYETSPEQLFY-------------------RIAHLNRGQQYL 1322
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
A+T AG + +VT + P I+ T L C + GDP P
Sbjct: 1323 LWVAAVTSAGR--GNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPA 1380
Query: 449 ISWLK--EGFTFP-GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
+ W K E P D I GTL ++ ++ D+G YTC AT++ G + L V
Sbjct: 1381 VKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLV 1440
Query: 506 TESGATISKNYDLSDLPGPPSKPQVT--DVTKNSVTLSWQPGTPGTLPASAYIIEAFSQS 563
PP +P++T + +S+TL+W PG G ++++ +S
Sbjct: 1441 QV----------------PPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQ-YSVD 1483
Query: 564 VSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQG 602
S W+ V + + L+ T Y + A N G
Sbjct: 1484 NSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVG 1522
Score = 43.1 bits (100), Expect = 0.002
Identities = 27/78 (34%), Positives = 35/78 (44%), Gaps = 5/78 (6%)
Query: 242 VEFRCQVQGDPQPTVRWKKD--DADLP---RGRYDIKDDYTLRIKKTMSTDEGTYMCIAE 296
V C GDP P V+W KD D+ +P G I + TL ++ + D G Y C A
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTAT 1426
Query: 297 NRVGKMEASATLTVRAPP 314
N G L V+ PP
Sbjct: 1427 NTGGFDTIIVNLLVQVPP 1444
Score = 38.1 bits (87), Expect = 0.059
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 12/88 (13%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS---HRMLLP 86
P +I+ V + L C + G P P ++W KD E D P S HR++
Sbjct: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARN 114
+G+L LR V D G Y C A N
Sbjct: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
Score = 35.8 bits (81), Expect = 0.29
Identities = 17/56 (30%), Positives = 25/56 (44%), Gaps = 4/56 (7%)
Query: 159 GHPEPTIYWKKDK----VRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 210
G P P + W KD + + R+ G L++ + D+G YTC TN G
Sbjct: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 228 bits (582), Expect = 2e-59
Identities = 228/832 (27%), Positives = 352/832 (42%), Gaps = 87/832 (10%)
Query: 27 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
ED P+I+ S+ +VS EP +L C +G P PTI W D + + R +M+
Sbjct: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPI-LKGGSHRISQMITS 461
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA- 145
G++ + + + D G Y C A N G V A + V R P + A
Sbjct: 462 EGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRPMKNITAI 516
Query: 146 AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKS-DAGMYTC 203
AG + C+ G+P +I W K+ + +++ G L +S+ +K D G YTC
Sbjct: 517 AGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
Query: 204 VGTNMVGERDSDPAELTVFERP-----TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW 258
S +TV P F R I Q V V V GD T+ W
Sbjct: 576 NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVV-----VSGDLPITITW 630
Query: 259 KKDDADLPRGRYDIKD--DYT--LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
+KD +P D D+T LRI G Y CIA N +E + L VR PP
Sbjct: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
Query: 315 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGSQNLLFPNQPQQPNSRCSVSPT 373
+FVV+PRDQ G+ V C +G P P + W+ +G+ F QP N R V
Sbjct: 691 KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQF--QPIALNGRIQVLSN 748
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
G L I ++ D+GYY+C+ G+ ++K+ LT + P +I P N TLA G
Sbjct: 749 GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSM-----YLTVKIPAMITSYP-NTTLATQG 802
Query: 434 TAL-LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQ-------GTLQIKNLRISDTGT 485
+ C A G+ ++ W KE R + + TLQI D+G
Sbjct: 803 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 862
Query: 486 YTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 545
++C A +S GE L V E P P + ++ DV ++TL W G
Sbjct: 863 FSCHAINSYGEDRGIIQLTVQE--------------PPDPPEIEIKDVKARTITLRWTMG 908
Query: 546 TPGTLPASAYIIEAFSQSVSNSWQTVAN----HVKTTLYTVRGLRPNTIYLFMVRAINPQ 601
G P + Y IE ++ S+SW + + T+ + P++ Y + A N
Sbjct: 909 FDGNSPITGYDIEC--KNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRI 966
Query: 602 GLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR- 660
G S+PS ++ T D + P ++ ++ +++VTW +
Sbjct: 967 GKSEPS--NELTITADEAAPDGPPQEVHLEP--------------ISSQSIRVTWKAPKK 1010
Query: 661 --QPQFIQGYRVMYRQ-TSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFN 717
Q I+GY++ YR+ ++G + ++D +E L NL K Y + V+
Sbjct: 1011 HLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE-VYTLDNLNKFTQYGLVVQACNR 1069
Query: 718 EFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI 777
G S+ T E+ PS PP++V + + SIS+SW + NGI+Q +++
Sbjct: 1070 AGTGPSSQEIITTTLEDVPSYPPENVQAIAT---SPESISISWSTLSKEALNGILQGFRV 1126
Query: 778 --WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 827
W + K + S+ + GL Y ++V A T AG GV+SE
Sbjct: 1127 IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178
Score = 157 bits (397), Expect = 7e-38
Identities = 206/851 (24%), Positives = 332/851 (39%), Gaps = 134/851 (15%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL--PSG 88
P + ++ G T ++C+ G P +I+WYK+ + P +HR + +G
Sbjct: 504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL------PFNHRQVAFENNG 557
Query: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEA-VSRNASLEVALLRDDFRQNPTDVVVAAG 147
+L + + + DEG Y C N L + +S + S+ V + F Q + G
Sbjct: 558 TLKLSDV----QKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIG 610
Query: 148 EPAILECQPPRGHPEPTIYWKKDK--------VRIDDKEERISIRGGKLMISNTRKSDAG 199
+ + C G TI W+KD V ID+ + S+R ISN G
Sbjct: 611 QRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLR-----ISNLSLMHNG 665
Query: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
YTC+ N + ++L V P F+ +P +Q + +AV C +G P PT+ WK
Sbjct: 666 NYTCIARNEAAAVEHQ-SQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724
Query: 260 -KDDADLPR-------GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK-MEASATLTV 310
A +P+ GR + + +L IK + D G Y+C N VG + S LTV
Sbjct: 725 FSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
Query: 311 RAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSV 370
+ P P + QG+ C G V W+KE ++ P+ S
Sbjct: 785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKE--DRII---NPEMARYLVST 839
Query: 371 SPTGDLTITNIQ-----RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 425
G+ I+ +Q R D+G++ C A+ G QL V + PP I ++
Sbjct: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQE--PPDPPEIEIKDVK 897
Query: 426 NQTLAV------DGTALL-----KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQ 474
+T+ + DG + + +CK D SW T + + +
Sbjct: 898 ARTITLRWTMGFDGNSPITGYDIECKNKSD-----SWDSAQRT------KDVSPQLNSAT 946
Query: 475 IKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVT 534
I ++ S T + A + G++ S L +T A GPP + + ++
Sbjct: 947 IIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD---------GPPQEVHLEPIS 997
Query: 535 KNSVTLSWQPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPN 588
S+ ++W+ Y I S ++Q V T+ +YT+ L
Sbjct: 998 SQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKF 1057
Query: 589 TIYLFMVRAINPQGLSDPSPMSDPVRTQDI-SPPAQGVDHRQVQKELGDVLVRLHNPVVL 647
T Y +V+A N G S +D+ S P + V +
Sbjct: 1058 TQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQ-----------------AIAT 1100
Query: 648 TPTTVQVTWTV---DRQPQFIQGYRVMYRQTSGLQATSSWQNL-DAKV-------PTERS 696
+P ++ ++W+ + +QG+RV+Y W NL D ++ T+ S
Sbjct: 1101 SPESISISWSTLSKEALNGILQGFRVIY-----------WANLMDGELGEIKNITTTQPS 1149
Query: 697 AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 756
L L+K Y I+V + G+ SE RT E+ P PP V +++ +
Sbjct: 1150 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAA---SASMV 1205
Query: 757 SVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAA 816
VSW PP NGII++Y ++C S I L QY V V A
Sbjct: 1206 FVSWLPPLK--LNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVA 1263
Query: 817 STSAGVGVKSE 827
TSAG G SE
Sbjct: 1264 VTSAGRGNSSE 1274
Score = 145 bits (365), Expect = 3e-34
Identities = 206/831 (24%), Positives = 327/831 (39%), Gaps = 99/831 (11%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
P + P V S G +L+C G + WY++GE + K+ +
Sbjct: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL--RDDFRQNPTDVVVAAG 147
+ ++ K D G+Y C R + +S ++V L ++ VV+
Sbjct: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPA 421
Query: 148 EPAILECQPPRGHPEPTIYWKKD-----KVRIDDKEERISIRG---GKLMISNTRKSDAG 199
EP L C +G P PTI W D K + I+ G L IS+++ D G
Sbjct: 422 EPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGG 480
Query: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
+Y C N G A + V P +R N + C+V G P +++W
Sbjct: 481 VYRCTANNSAGV-VLYQARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWY 538
Query: 260 KDDADLPRGRYDI--KDDYTLRIKKTM-STDEGTYMC--IAENRVGKMEASATLTVRAPP 314
K+ LP + +++ TL++ DEG Y C + + ++ + S +TV+ PP
Sbjct: 539 KNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQ-SVHVTVKVPP 597
Query: 315 --QFVVRPRDQIVAQGRTVTFPCETKGNPQP-AVFWQKEGSQNLLFPNQPQQPNSRCSVS 371
Q PR I G+ V PC P + WQK+G P + ++
Sbjct: 598 FIQPFEFPRFSI---GQRVFIPCVVVSGDLPITITWQKDGR-----PIPGSLGVTIDNID 649
Query: 372 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 431
T L I+N+ G Y C A A ++ ++QL V R PP + P +Q
Sbjct: 650 FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQDGIY 703
Query: 432 DGTALLKCKATGDPLPVISW-LKEGFTFPGRDP-----RATIQEQGTLQIKNLRISDTGT 485
+L C A G P+P I W +G P P R + G+L IK++ D+G
Sbjct: 704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
Query: 486 YTCVATSSSG-ETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQP 544
Y C ++ G + S S L V S G + T + + + W+
Sbjct: 764 YLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
Query: 545 GTPGTLPASA-YIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGL 603
P A Y++ S + V V +TL + +R ++ + F AIN G
Sbjct: 824 EDRIINPEMARYLV---------STKEVGEEVISTLQILPTVREDSGF-FSCHAINSYG- 872
Query: 604 SDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQ 663
D + V+ + PP + E+ DV R T+ + WT+
Sbjct: 873 EDRGIIQLTVQ-EPPDPP---------EIEIKDVKAR----------TITLRWTMGFDGN 912
Query: 664 F-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGM 722
I GY + + S + S Q P SA ++++ TY I++ +
Sbjct: 913 SPITGYDIECKNKS--DSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE 970
Query: 723 DSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI----W 778
S T+ E AP PPQ V + + +S SI V+W P QNGII+ Y+I +
Sbjct: 971 PSNELTITADEAAPDGPPQEVHLEPI---SSQSIRVTWKAPKKHLQNGIIRGYQIGYREY 1027
Query: 779 CLGNETRFHINKTVDAAIRSVI--IGGLFPGIQYRVEVAASTSAGVGVKSE 827
G +F+I +VD + S + + L QY + V A AG G S+
Sbjct: 1028 STGGNFQFNI-ISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077
Score = 124 bits (312), Expect = 5e-28
Identities = 126/497 (25%), Positives = 210/497 (42%), Gaps = 58/497 (11%)
Query: 39 DVIVSKGEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPSGSL------- 90
+V+ + T + C A G P T+ WY GE + D R + P+G+L
Sbjct: 33 EVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPP 88
Query: 91 -FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
F ++H + +Y C A N G+ S++ ++ A+LR+ + D G
Sbjct: 89 SSFSTLIH-------DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNV 140
Query: 150 AILECQPPRGHPE--PTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYT--CVG 205
A+ +C P + W+KD V + + G L I + + D G+Y C+
Sbjct: 141 AVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNED-GLYNYRCIT 199
Query: 206 TNM-VGE-RDSDPAELTVFE----RPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
+ GE R S+ A L V + P+ L ++ + + VE C+ G P+P RW
Sbjct: 200 RHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWL 259
Query: 260 KDDADLP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 318
KD+ L GR+ K L I+ +D G+Y+C NR G + L V+ P + +
Sbjct: 260 KDNMPLELSGRFQ-KTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATI 318
Query: 319 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
PR + G V+ C G + W + G +L P + N R + +L +
Sbjct: 319 SPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNG--EILNPGK----NVRITGINHENLIM 372
Query: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTD---VLTDRPPPIILQGPANQTLAVDGTA 435
++ +SD G Y C + K +L D V+ + P I+ + + ++
Sbjct: 373 DHMVKSDGGAYQC--------FVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPV 424
Query: 436 LLKCKATGDPLPVISW-LKEGFTFPGRDPRAT--IQEQGT----LQIKNLRISDTGTYTC 488
L C G PLP I+W L + G R + I +G L I + ++ D G Y C
Sbjct: 425 SLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRC 484
Query: 489 VATSSSGETSWSAVLDV 505
A +S+G + A ++V
Sbjct: 485 TANNSAGVVLYQARINV 501
Score = 82.4 bits (202), Expect = 3e-15
Identities = 69/283 (24%), Positives = 119/283 (42%), Gaps = 42/283 (14%)
Query: 436 LLKCKATGDPLPVISWLKEGFTFPGR---DPRATIQEQGTLQIKNLRISDTGTYTCVATS 492
+L CKA GDP P + W+K+ P D R +I G+ I+ ++ D+G Y+C+A +
Sbjct: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
Query: 493 SSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVT--DVTKNSVTLSWQPGTPGTL 550
+ G L V PP +P++T T +S+TLSW PG G
Sbjct: 1364 NWGSDEIILNLQVQV----------------PPDQPRLTVSKTTSSSITLSWLPGDNGGS 1407
Query: 551 PASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMS 610
YI++ +S+ S W + Y + L+ T Y F + A N G P +S
Sbjct: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
Query: 611 DPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRV 670
+ + + + Q +++ + VRL+ + W P I + +
Sbjct: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGWNDGGCP--ITSFTL 1511
Query: 671 MYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVR 713
YR T+ W + +S +L +L++ YE+++R
Sbjct: 1512 EYRPF----GTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR 1549
Score = 82.0 bits (201), Expect = 4e-15
Identities = 146/619 (23%), Positives = 239/619 (38%), Gaps = 75/619 (12%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRM-LLPS 87
PP+ V P D G+ LNC AEG P PTI W + G V + + R+ +L +
Sbjct: 689 PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSN 748
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
GSL +V + D G Y+C N +G VS++ L V + P + G
Sbjct: 749 GSLLIKHVV-----EEDSGYYLCKVSNDVGADVSKSMYLTVKIPAM-ITSYPNTTLATQG 802
Query: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK--------LMISNTRKSDAG 199
+ + C G + W+K+ I+ + R + + L I T + D+G
Sbjct: 803 QKKEMSCTA-HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSG 861
Query: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT---- 255
++C N GE D +LTV E P I V + + G+ T
Sbjct: 862 FFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDI 920
Query: 256 -VRWKKDDADLPRGRYDIKDDY-TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA- 312
+ K D D + D+ + I + + A+NR+GK E S LT+ A
Sbjct: 921 ECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITAD 980
Query: 313 ------PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS 366
PPQ V + I +Q VT+ K + + G + Q +
Sbjct: 981 EAAPDGPPQEV--HLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQF--N 1036
Query: 367 RCSVSPTGD---LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP--PPIIL 421
SV +GD T+ N+ + + QA AG+ + ++ +T L D P PP +
Sbjct: 1037 IISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEI-ITTTLEDVPSYPPENV 1095
Query: 422 QGPAN--QTLAVDGTALLKCKATG--DPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKN 477
Q A +++++ + L K G VI W A + + +IKN
Sbjct: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYW-------------ANLMDGELGEIKN 1142
Query: 478 LRISDTGTYTCVATSSSGETSWSA-VLDVTESGATISKNYDLS----DLPGPPSKPQVTD 532
+ + + T++S VL T +G + + D+PGPP+ +
Sbjct: 1143 ITTTQP---SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAA 1199
Query: 533 VTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPN 588
+ + V +SW P P L II ++ S+ + TV + + + Y + L N
Sbjct: 1200 ASASMVFVSWLP--PLKLNG---IIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRN 1254
Query: 589 TIYLFMVRAINPQGLSDPS 607
Y V A+ G + S
Sbjct: 1255 RQYSVWVVAVTSAGRGNSS 1273
Score = 50.4 bits (119), Expect = 1e-05
Identities = 27/74 (36%), Positives = 34/74 (45%), Gaps = 5/74 (6%)
Query: 246 CQVQGDPQPTVRWKKDDADLPR-----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 300
C+ GDP P V+W KD P GR I + + I+ + D G Y CIA N G
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
Query: 301 KMEASATLTVRAPP 314
E L V+ PP
Sbjct: 1367 SDEIILNLQVQVPP 1380
Score = 48.1 bits (113), Expect = 6e-05
Identities = 36/143 (25%), Positives = 63/143 (44%), Gaps = 14/143 (9%)
Query: 274 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV----RAPPQFVVRPRDQIVAQGR 329
D ++ RI + + +A G+ +S +TV +AP + + +
Sbjct: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301
Query: 330 TVTFPCETKGNPQPAVFWQKE--GSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 387
+ PC+ G+P PAV W K+ G+ +L+ + R S+ G I ++ D+G
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKAEDSG 1355
Query: 388 YYICQALTVAGS--ILAKAQLEV 408
YY C A GS I+ Q++V
Sbjct: 1356 YYSCIANNNWGSDEIILNLQVQV 1378
Score = 38.1 bits (87), Expect = 0.059
Identities = 27/88 (30%), Positives = 37/88 (42%), Gaps = 6/88 (6%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
P RI+ V + L CKA G P+P ++W KD + R + +GS
Sbjct: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPS-LVTIDGRRSIFSNGS 1343
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLG 117
F +R V D G Y C+A N G
Sbjct: 1344 -FIIRTVKAE----DSGYYSCIANNNWG 1366
Score = 34.3 bits (77), Expect = 0.85
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 9/66 (13%)
Query: 151 ILECQPPRGHPEPTIYWKKDK------VRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 204
+L C+ G P P + W KD V ID + S G +I + D+G Y+C+
Sbjct: 1304 VLPCKAV-GDPSPAVKWMKDSNGTPSLVTIDGRRSIFS--NGSFIIRTVKAEDSGYYSCI 1360
Query: 205 GTNMVG 210
N G
Sbjct: 1361 ANNNWG 1366
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 219 bits (557), Expect = 2e-56
Identities = 218/765 (28%), Positives = 317/765 (41%), Gaps = 88/765 (11%)
Query: 42 VSKGEPTTLNC-KAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRR 100
VS+G LN P P + W+++G ++ P + + L L
Sbjct: 202 VSQGRAAILNLLPITSYPRPQVTWFREGHKII-----PSNRIAITLENQLVILAT----- 251
Query: 101 SKPDEGSYVCVARNYLGEAVSRNASLEVALLRD---DFRQNPTDVV-------VAAGEPA 150
+ D G+Y A N + + +++ RD PT VV VA
Sbjct: 252 TTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSET 311
Query: 151 ILEC-QPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMV 209
LEC R + ++ WK++ VRI G +L ISN +D G Y C +
Sbjct: 312 TLECIASARPVEDLSVTWKRNGVRITSGLHSF---GRRLTISNPTSADTGPYVCEAA--L 366
Query: 210 GERDSDPAELTVF----ERPTFLRRPINQVVLE-EEAVEFRCQVQGDPQPTVRWKKDDAD 264
+PA T F E P F P +++ E EE V+ CQ G P PT++W KD
Sbjct: 367 PGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAIS 426
Query: 265 LPR---GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV-RAPPQFVVRP 320
+ R RY + LRI+K D G + C A N G+++ L V P F RP
Sbjct: 427 ISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRP 486
Query: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
D V G T CE G P+PA+ W++E ++L + P R + +G L I
Sbjct: 487 VDTTVTDGMTAILRCEVSGAPKPAITWKREN--HILASGSVRIP--RFMLLESGGLQIAP 542
Query: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 440
+ DAG Y C A GS+ A A L V + + I+ P + + TA L C
Sbjct: 543 VFIQDAGNYTCYAANTEGSLNASATLTVWNRTS------IVHPPEDHVVIKGTTATLHCG 596
Query: 441 ATGDPLPVIS--WLKEGFTF-PGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
AT DP + W K+ P R +++ G+L I D G Y+C S G
Sbjct: 597 ATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGND 656
Query: 498 SWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNS--VTLSWQPGTPGTLPASAY 555
S A L+V E LP P V+ + +S V LSW G P Y
Sbjct: 657 SRMARLEVIE-------------LPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYY 703
Query: 556 IIEAFSQSVSNS-WQTVANHV--KTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP 612
I+E S +NS W+ ++V + T TV GL P Y F V A+N G S +
Sbjct: 704 IVEL---SENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSR 760
Query: 613 VRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMY 672
+ + P A + + ++V+ P P T ++GY + Y
Sbjct: 761 LMLPEEPPSAPPKNIVASGRTNQSIMVQWQPP----PET--------EHNGVLRGYILRY 808
Query: 673 RQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTT 732
R +GL +N+ + P ++ +L YEI+V Y G+ S + T T
Sbjct: 809 R-LAGLPGEYQQRNITS--PEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTL 865
Query: 733 EEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI 777
+ P+APPQ+V V NST+I W+PPP NGI Q YK+
Sbjct: 866 QGVPTAPPQNVQTEAV---NSTTIQFLWNPPPQQFINGINQGYKL 907
Score = 167 bits (423), Expect = 6e-41
Identities = 216/856 (25%), Positives = 330/856 (38%), Gaps = 105/856 (12%)
Query: 27 EDFPPRIVEHPSD-VIVSKGEPTTLNCKAEGRPTP--TIEWYKDGERVETDKDDPRSHRM 83
E P IV P + +V+ TTL C A RP ++ W ++G R+ +
Sbjct: 289 ETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHS------ 342
Query: 84 LLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-FRQNPTDV 142
F R+ + D G YVC A A+ + ++ F P
Sbjct: 343 -------FGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESR 395
Query: 143 VVAAGEPAI-LECQPPRGHPEPTIYWKKDKV---RIDDKEERISIRGGKLMISNTRKSDA 198
+ A E + + CQ G P PT+ W KD + R+ + ++ GG L I R D+
Sbjct: 396 ISAEVEETVDIGCQA-MGVPLPTLQWYKDAISISRLQNPRYKVLASGG-LRIQKLRPEDS 453
Query: 199 GMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW 258
G++ C +N GE + P F +RP++ V + RC+V G P+P + W
Sbjct: 454 GIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITW 513
Query: 259 KKDDADLPRG-----RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 313
K+++ L G R+ + + L+I D G Y C A N G + ASATLTV
Sbjct: 514 KRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNR 573
Query: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
V P D +V +G T T C +P+ ++ + + L P+ SR V
Sbjct: 574 TSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSS----TSRIVVEKD 629
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
G L I+ D G Y C+ ++ G+ A+LEV + L P +++ ++ + AV
Sbjct: 630 GSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIE-LPHSPQNLLVSPNSSHSHAV-- 686
Query: 434 TALLKCKATGDPLPVISWLKEGFTFPGRDPRA--TIQEQGTLQIKNLRISDTG---TYTC 488
V+SW++ F G P ++ + +S+ G T
Sbjct: 687 --------------VLSWVRP---FDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVT 729
Query: 489 VATSSSGETSWSAVLDVTESG-ATISKNYDLSDLPG-PPSKPQVTDV----TKNSVTLSW 542
V+ + T V V E G S LP PPS P V T S+ + W
Sbjct: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789
Query: 543 QPG--TPGTLPASAYIIEAFSQSVSNSWQTV-ANHVKTTLYTVRGLRPNTIYLFMVRAIN 599
QP T YI+ + +Q + V L T Y V A N
Sbjct: 790 QPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYN 849
Query: 600 PQGLSDPSPMSDPVRTQDI--SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT 657
GL S Q + +PP + VQ E + TT+Q W
Sbjct: 850 GAGLGVFSRAVTEYTLQGVPTAPP------QNVQTE------------AVNSTTIQFLWN 891
Query: 658 VDRQPQFI----QGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVR 713
Q QFI QGY+++ +A + + + NLKK Y V
Sbjct: 892 PPPQ-QFINGINQGYKLLAWPADAPEAVTV-VTIAPDFHGVHHGHITNLKKFTAYFTSVL 949
Query: 714 PYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQ 773
+ G S + V T E+ P A V L+ TS+ VSW P +NGII
Sbjct: 950 CFTTPGDGPPSTPQLVWTQEDKPGA----VGHLSFTEILDTSLKVSWQEPL--EKNGIIT 1003
Query: 774 EYKI-WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVG------VKS 826
Y+I W + + T+++ I GL Y ++VAA T+ G G + S
Sbjct: 1004 GYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISS 1063
Query: 827 EPQPIIIGRRNEVVIT 842
P + G + +VI+
Sbjct: 1064 GVPPDLPGAPSNLVIS 1079
Score = 160 bits (406), Expect = 6e-39
Identities = 139/503 (27%), Positives = 208/503 (41%), Gaps = 50/503 (9%)
Query: 24 LRQEDFPPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHR 82
L Q+D P P I +G L C AEG +W +D + T + ++
Sbjct: 97 LAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSE---YK 153
Query: 83 MLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV 142
++PS K D G Y CV RN +G + R + ++VA + F
Sbjct: 154 YIIPS------------LQKLDAGFYRCVVRNRMGALLQRKSEVQVAYM-GSFMDTDQRK 200
Query: 143 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYT 202
V+ G AIL P +P P + W ++ +I +L+I T SDAG Y
Sbjct: 201 TVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYY 260
Query: 203 CVGTN-MVGERDSDP-AELTVFE--------RPTFLRRPINQVVL---EEEAVEFRCQVQ 249
N GE + P L++ PT + P N+ V+ E +E +
Sbjct: 261 VQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASAR 320
Query: 250 GDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKME---ASA 306
+V WK++ + G + L I S D G Y+C A E A+A
Sbjct: 321 PVEDLSVTWKRNGVRITSGLHSF--GRRLTISNPTSADTGPYVCEAALPGSAFEPARATA 378
Query: 307 TLTVRAPPQFVVRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPN 365
L + PP F P +I A+ TV C+ G P P + W K+ + + N
Sbjct: 379 FLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAI------SISRLQN 432
Query: 366 SRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 425
R V +G L I ++ D+G + C A G I L+VT++ P+ Q P
Sbjct: 433 PRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNI-----APVFTQRPV 487
Query: 426 NQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPG---RDPRATIQEQGTLQIKNLRISD 482
+ T+ TA+L+C+ +G P P I+W +E R PR + E G LQI + I D
Sbjct: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD 547
Query: 483 TGTYTCVATSSSGETSWSAVLDV 505
G YTC A ++ G + SA L V
Sbjct: 548 AGNYTCYAANTEGSLNASATLTV 570
Score = 103 bits (258), Expect = 9e-22
Identities = 98/340 (28%), Positives = 148/340 (43%), Gaps = 55/340 (16%)
Query: 522 PGPPSKPQV--TDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHV--KT 577
P PP + V +VT S+ L W PG+ G P + ++ + WQT ++ + +
Sbjct: 1477 PAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQV-RELPRGEWQTYSSSISHEA 1535
Query: 578 TLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRT-QDI--SPPAQGVDHRQVQKEL 634
T V LRP T Y ++A N G SD S ++ V T QD+ PP
Sbjct: 1536 TACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPP------------- 1582
Query: 635 GDVLVRLHNPVVLTPTTVQVTWTVDRQPQF---IQGYRVMYRQT---------------- 675
G V H T ++V + W R +QGYR+ YR+
Sbjct: 1583 GSVSATPH-----TTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNP 1637
Query: 676 ----SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRT 731
+ L A SS++ +++ T L +LKK YE+ + Y + S V
Sbjct: 1638 IALHAELTAQSSFKTVNSS-STSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFV 1696
Query: 732 TEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI--WCLGNETRFHIN 789
E AP+ PQ+V V + ++ + V+WDPPPP+ QNG IQ YKI W ++
Sbjct: 1697 GEAAPAMAPQNVQVTPL---TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKM 1753
Query: 790 KTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQ 829
K + V + L +Y V ++A +AG G KS+PQ
Sbjct: 1754 KVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQ 1793
Score = 99.8 bits (247), Expect = 2e-20
Identities = 91/323 (28%), Positives = 148/323 (45%), Gaps = 37/323 (11%)
Query: 520 DLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSN--SWQTV---ANH 574
DLPG PS +++++ S TL ++PG G S +I+E ++ + W T+ N
Sbjct: 1068 DLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENE 1127
Query: 575 VKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKEL 634
+ + L P T Y F ++ +N G S SP S ++T P
Sbjct: 1128 PDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPT--------- 1178
Query: 635 GDVLVRLHNPVVLTPTTVQVTWTVDRQPQF-----IQGYRVMYRQTSGLQATSSWQNLDA 689
V VR + T++++ W Q+ GYR+ Y + S LQ+++ Q +
Sbjct: 1179 -SVTVR-----TASETSLRLRWVPLPDSQYNGNPESVGYRIKYWR-SDLQSSAVAQVVSD 1231
Query: 690 KVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVG 749
++ ER + L++ + YE++++ + G SE RT E PSA P++V+ V
Sbjct: 1232 RL--EREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAV- 1288
Query: 750 SYNSTSISVSWDPPPPDHQNGIIQEYKIWC----LGNETRFHINKTVDAAIRSVIIGGLF 805
+ST I ++W P QNG+I YKI L E R HI + +S ++ GL
Sbjct: 1289 --SSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVR--GNHTQSALLAGLR 1344
Query: 806 PGIQYRVEVAASTSAGVGVKSEP 828
+ Y ++V A T G GV S P
Sbjct: 1345 KFVLYELQVLAFTRIGNGVPSTP 1367
Score = 70.1 bits (170), Expect = 1e-11
Identities = 61/264 (23%), Positives = 115/264 (43%), Gaps = 27/264 (10%)
Query: 520 DLPGPPSKPQVTDVTKNSVTLSWQ-PGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTT 578
D PGPP + +V SV + WQ P P + I + S +++ TV
Sbjct: 1376 DAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVR 1435
Query: 579 LYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVL 638
+T L P + Y+F + A QG +P + + T+ PA + Q E
Sbjct: 1436 QFTATDLAPESAYIFRLSAKTRQGWGEPLE-ATVITTEKRERPAPPRELLVPQAE----- 1489
Query: 639 VRLHNPVVLTPTTVQVTWTVDRQ-PQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSA 697
+T ++++ W I+ + + R+ WQ + + E +A
Sbjct: 1490 --------VTARSLRLQWVPGSDGASPIRYFTMQVREL----PRGEWQTYSSSISHEATA 1537
Query: 698 VLVN-LKKGVTYEIKVRPYFNEFQGMD--SESKTVRTTEEAPSAPPQSVTVLTVGSYNST 754
+V+ L+ +Y+++++ N+ D SE++ V T ++ P PP SV+ + ++
Sbjct: 1538 CVVDRLRPFTSYKLRLKA-TNDIGDSDFSSETEAVTTLQDVPGEPPGSVSAT---PHTTS 1593
Query: 755 SISVSWDPPPPDHQNGIIQEYKIW 778
S+ + W PP + NG++Q Y+I+
Sbjct: 1594 SVLIQWQPPRDESLNGLLQGYRIY 1617
Score = 55.8 bits (133), Expect = 3e-07
Identities = 86/337 (25%), Positives = 136/337 (40%), Gaps = 64/337 (18%)
Query: 525 PSKPQVTDVTKNSVTLSWQP-------GTPGTLPASAYIIEAFSQSVSNSWQTVANHVKT 577
P+ V ++ S+ L W P G P ++ Y I+ + + +S VA V
Sbjct: 1177 PTSVTVRTASETSLRLRWVPLPDSQYNGNPESV---GYRIKYWRSDLQSS--AVAQVVSD 1231
Query: 578 TL---YTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVR--TQDISPPAQGVDHRQVQK 632
L +T+ L Y ++A N G P S+ VR T++ P A V
Sbjct: 1232 RLEREFTIEELEEWMEYELQMQAFNAVGAG---PWSEVVRGRTRESVPSAAP---ENVSA 1285
Query: 633 ELGDVLVRLHNPVVLTPTTVQVTWT-VDRQPQ--FIQGYRVMYRQTSGLQATSSWQNLDA 689
E ++ T + +TWT V Q Q I GY++++R ++LD
Sbjct: 1286 E------------AVSSTQILLTWTSVPEQDQNGLILGYKILFRA----------KDLDP 1323
Query: 690 KVPTE-------RSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTV-RTTEEAPSAPPQ 741
+ + +SA+L L+K V YE++V + G+ S + RT ++AP P +
Sbjct: 1324 EPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVR 1383
Query: 742 SVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVD--AAIRSV 799
L TS+ + W PP+ NGII Y+I + H TV+ A +R
Sbjct: 1384 ----LVFPEVRLTSVRIVWQ--PPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQF 1437
Query: 800 IIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRR 836
L P Y ++A T G G E I +R
Sbjct: 1438 TATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKR 1474
Score = 55.8 bits (133), Expect = 3e-07
Identities = 72/316 (22%), Positives = 121/316 (38%), Gaps = 32/316 (10%)
Query: 525 PSKPQVTDVTKNSVTLSWQPGTPGTLPASA-----YIIEAFSQSVSNSWQTVANHVKTTL 579
P QVT +T + + ++W P P + + Y EA SQ+ + + + + +
Sbjct: 1705 PQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVL--FLPEPV 1762
Query: 580 YTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPV--RTQDISPPAQGVDHRQVQKELGDV 637
++ L +T YL + A N G P SDP RT +P G E+
Sbjct: 1763 VRLKNLTSHTKYLVSISAFNAAG---DGPKSDPQQGRTHQAAP---GAPSFLAFSEI--- 1813
Query: 638 LVRLHNPVVLTPTTVQVTWTVDRQPQ-FIQGYRVMYRQTSGLQATSSWQNLDAKVPTERS 696
T TT+ V+W +QGYRV+Y + +Q S ++ + +R
Sbjct: 1814 ----------TSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRW 1863
Query: 697 AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 756
+ +L KGVTY +V+ + + T E +P +P VL S + ++
Sbjct: 1864 LKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRD---VLVTKSASELTL 1920
Query: 757 SVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAA 816
+ G + E + G F + A ++ + L G+ Y V A
Sbjct: 1921 QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA 1980
Query: 817 STSAGVGVKSEPQPII 832
AG G S P +
Sbjct: 1981 VNEAGYGEPSNPSTAV 1996
Score = 48.9 bits (115), Expect = 3e-05
Identities = 37/118 (31%), Positives = 49/118 (41%), Gaps = 7/118 (5%)
Query: 509 GATISKNYDLSDLPGPPSKPQVTDVTKNS--VTLSWQPGTPGTLPASAYIIEAFSQSVSN 566
G + N G P P+ VTK++ +TL W G G P + Y+IEA S
Sbjct: 1887 GPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEA-RPSDEG 1945
Query: 567 SWQTVANHV--KTTLYTVR--GLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 620
W + T YT+ LR Y F V A+N G +PS S V Q +P
Sbjct: 1946 LWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAP 2003
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 218 bits (556), Expect = 2e-56
Identities = 230/824 (27%), Positives = 328/824 (39%), Gaps = 97/824 (11%)
Query: 42 VSKGEPTTLNC-KAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRR 100
VS GE + + P P + W++DG ++ P S + +L L V
Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIP-----PSSRIAITLENTLVILSTV---- 174
Query: 101 SKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV-------------VVAAG 147
PD G Y A N + N + + L + P D VVA
Sbjct: 175 -APDAGRYYVQAVN---DKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGT 230
Query: 148 EPAILECQP-PRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGT 206
LEC R + I WKKD V + IS +L I N SDAG Y C
Sbjct: 231 SEVTLECVANARPLIKLHIIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYEC--- 284
Query: 207 NMVGERDSDP-----AELTVFERPTFLRRPINQVVLE-EEAVEFRCQVQGDPQPTVRWKK 260
V S P A L+V E P F++ P + E E+ V+ CQ +G P P++ W K
Sbjct: 285 EAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYK 344
Query: 261 DDADLP---RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA-PPQF 316
D A + R+ ++D L+I + D G + C A N G+++ S L V + P
Sbjct: 345 DAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI 404
Query: 317 VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL 376
P D V G +V CET G P+PA+ WQK + +L Q P R + +G L
Sbjct: 405 TRGPLDSTVIDGMSVVLACETSGAPRPAITWQK--GERILASGSVQLP--RFTPLESGSL 460
Query: 377 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL 436
I+ SDAG Y C A G A A L V PP +Q++ A
Sbjct: 461 LISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPP------QDQSVIKGTQAS 514
Query: 437 LKCKATGDPLPVIS--WLKEGFTFPGRD-PRATIQEQGTLQIKNLRISDTGTYTCVATSS 493
+ C T DP I W K+G T PR + G+L I D GTYTC S+
Sbjct: 515 MVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISA 574
Query: 494 SGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVT--DVTKNSVTLSWQPGTPGTLP 551
G S SA L V + LP P P T V + ++ L+W G P
Sbjct: 575 GGNDSRSAHLRVRQ-------------LPHAPEHPVATLSTVERRAINLTWTKPFDGNSP 621
Query: 552 ASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSD 611
YI+E + + + K T TV+GL P Y F + A+N G S ++
Sbjct: 622 LIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE 681
Query: 612 PVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVM 671
V + P A + + ++++ P Q ++GY +
Sbjct: 682 RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPP------------PESHQNGILKGYIIR 729
Query: 672 YRQTSGLQATSSWQNL-DAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVR 730
Y +GL ++N+ DA V + +L +L YEI+V Y + G+ S T
Sbjct: 730 YC-LAGLPVGYQFKNITDADV---NNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEW 785
Query: 731 TTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNE-----TR 785
T + P+ PP +V NST+I +W+ P P NGI Q YK+ E T
Sbjct: 786 TLQGVPTVPPGNVHAEAT---NSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTM 842
Query: 786 FHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQ 829
+I + GL +Y V T+ G G +S PQ
Sbjct: 843 VTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQ 886
Score = 195 bits (496), Expect = 2e-49
Identities = 230/883 (26%), Positives = 342/883 (38%), Gaps = 123/883 (13%)
Query: 26 QEDFPPRIVEHPSDVIVS-KGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRML 84
Q+D P P V +G L C AEG +W + + + +R +
Sbjct: 21 QDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLE---YRYM 77
Query: 85 LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 144
+ S + G Y C+ RN +G + R ++VA + F + V
Sbjct: 78 ITS------------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYM-GSFEEGEKHQSV 124
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMY--T 202
+ GE A++ P+P + W +D +I L+I +T DAG Y
Sbjct: 125 SHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQ 184
Query: 203 CVGTNMVGERDSDPAELTVFE--------RPTFLRRPIN-QVVLEEEAVEFRCQVQGDP- 252
V + S P LTV PT + P N VV V C P
Sbjct: 185 AVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPL 244
Query: 253 -QPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMC---IAENRVGKMEASATL 308
+ + WKKD L G D + L I +D G Y C + + V + A L
Sbjct: 245 IKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 302
Query: 309 TVRAPPQFVVRPRDQIVAQ-GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSR 367
+V PPQFV P I A+ + V PC+ KG P P++ W K+ + + +R
Sbjct: 303 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAV------VEVEKLTR 356
Query: 368 CSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQ 427
G L I+ + D G + C A AG + L VT + P I +GP +
Sbjct: 357 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI-----APNITRGPLDS 411
Query: 428 TLAVDGTALLKCKATGDPLPVISWLK-EGFTFPG--RDPRATIQEQGTLQIKNLRISDTG 484
T+ + +L C+ +G P P I+W K E G + PR T E G+L I ISD G
Sbjct: 412 TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
Query: 485 TYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKP--QVTDVTKNSVTLSW 542
TYTC+AT+S G SA L V D S + G + VT + ++ W
Sbjct: 472 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIW 531
Query: 543 QP--GTPGTLPASAYIIEA-FSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAIN 599
+ T GT ++ S +S +W I + R I+
Sbjct: 532 EKDGATLGTESHPRIRLDRNGSLHISQTWS------------------GDIGTYTCRVIS 573
Query: 600 PQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPT----TVQVT 655
A G D R + + +PV T + +T
Sbjct: 574 ----------------------AGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLT 611
Query: 656 WTVDRQPQFIQGYRVMYRQTSGLQATSS-WQNLDAKV-PTERSAVLVNLKKGVTYEIKVR 713
WT + G + R + ++ W L A V P S + L +Y+ ++
Sbjct: 612 WT-----KPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLC 666
Query: 714 PYFNEFQGMDS-ESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGII 772
+ +G S +++ V EE P+APPQ+ V+ G N SI + W PPP HQNGI+
Sbjct: 667 AVNDVGKGQFSKDTERVSLPEEPPTAPPQN--VIASGRTNQ-SIMIQWQPPPESHQNGIL 723
Query: 773 QEYKI-WCL-GNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS---- 826
+ Y I +CL G + DA + ++++ L Y +EVAA SAG+GV S
Sbjct: 724 KGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVT 783
Query: 827 ----EPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGI 865
+ P + V E NS T + T P FI GI
Sbjct: 784 EWTLQGVPTVPPGN---VHAEATNSTTIRFTWNAPSPQFINGI 823
Score = 109 bits (273), Expect = 2e-23
Identities = 102/336 (30%), Positives = 144/336 (42%), Gaps = 46/336 (13%)
Query: 520 DLPGPPSKPQVT--DVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVK- 576
D P PPS+P V DV SV LSW+PG+ G P Y I+ + S W + V
Sbjct: 1398 DRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQT-RELPSGRWALHSASVSH 1456
Query: 577 -TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELG 635
+ + V L+P T Y F V+A N G S+ S S+ + T +P
Sbjct: 1457 NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP--------------- 1501
Query: 636 DVLVRLHNPVVLTPTTVQVTW---TVDRQPQFIQGYRVMYRQT--SGLQA---------- 680
D + + T T+V + W D+ + G+R+ YR+ GL+
Sbjct: 1502 DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
Query: 681 ------TSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEE 734
TS + + P+ L NL K YEI++ Y +G S + V E
Sbjct: 1562 ATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEA 1621
Query: 735 APSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI--WCLGNETRFHINKTV 792
P+A P++V V +T + V+W+PPP D QNG IQ YKI W KT+
Sbjct: 1622 VPTAAPRNVVV---HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTL 1678
Query: 793 DAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEP 828
A SV + L Y V VAA +AG G +S P
Sbjct: 1679 FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTP 1714
Score = 92.0 bits (227), Expect = 3e-18
Identities = 98/376 (26%), Positives = 162/376 (43%), Gaps = 47/376 (12%)
Query: 472 TLQIKNLRISDTGTYTC--VATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQ 529
TL+ + ++ TYT A +S G+ SA +TIS +LPGPP+
Sbjct: 950 TLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA--------STISSGVP-PELPGPPTNLG 1000
Query: 530 VTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSV--SNSW---QTVANHVKTTLYTVRG 584
++++ SVTL ++PG G S +++EA V W ++N V
Sbjct: 1001 ISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPD 1060
Query: 585 LRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNP 644
L P T Y F +R +N G S PS S ++T P ++ V L
Sbjct: 1061 LNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPP------------DMAPANVSLR-- 1106
Query: 645 VVLTPTTVQVTW------TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAV 698
+ T++ + W + P+ + GY++ Y ++ G T S D ER
Sbjct: 1107 -TASETSLWLRWMPLPEMEYNGNPESV-GYKIKYSRSDGHGKTLSHVVQDR---VERDYT 1161
Query: 699 LVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISV 758
+ +L++ Y ++V+ + G S++ RT E PS+ P +V+ L S+S+ V
Sbjct: 1162 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALAT---TSSSMLV 1218
Query: 759 SWDPPPPDHQNGIIQEYKIWC--LGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAA 816
W P +NG++ YK+ ++T+ + RS + GL + Y V+V A
Sbjct: 1219 RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA 1278
Query: 817 STSAGVGVKSEPQPII 832
T G G S P PI+
Sbjct: 1279 FTRIGDGSPSHP-PIL 1293
Score = 73.2 bits (178), Expect = 2e-12
Identities = 70/262 (26%), Positives = 113/262 (43%), Gaps = 21/262 (8%)
Query: 518 LSDLPGPPSKPQVTDVTKNSVTLSWQ-PGTPGTLPASAYIIEAFSQSVSNSWQTVANHVK 576
L D+PGPP +V SV L WQ P P + + I + + +N+
Sbjct: 1297 LDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPS 1356
Query: 577 TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGD 636
YT GL+P ++YLF + A +G + + V T + Q VQ+E D
Sbjct: 1357 ARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL--VVTTEKRDRPQPPSRPMVQQE--D 1412
Query: 637 VLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERS 696
V R +V ++W + + R QT L + W A V S
Sbjct: 1413 VRAR----------SVLLSW--EPGSDGLSPVRYYTIQTREL-PSGRWALHSASVSHNAS 1459
Query: 697 AVLVN-LKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTS 755
+ +V+ LK +Y+ +V+ + SE TT +A AP ++ T+L+V + +TS
Sbjct: 1460 SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA--APDEAPTILSVTPHTTTS 1517
Query: 756 ISVSWDPPPPDHQNGIIQEYKI 777
+ + W PP D NGI+ ++I
Sbjct: 1518 VLIRWQPPAEDKINGILLGFRI 1539
Score = 61.2 bits (147), Expect = 6e-09
Identities = 118/534 (22%), Positives = 195/534 (36%), Gaps = 89/534 (16%)
Query: 582 VRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVR--TQDISPPAQGVDHRQVQKELGDVLV 639
++ L T Y+ V A N G P S P + TQ +P A V
Sbjct: 1687 LKNLTGYTAYMVSVAAFNAAG---DGPRSTPTQGQTQQAAPSAPSS-------------V 1730
Query: 640 RLHNPVVLTPTTVQVTWTVDRQPQ-FIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAV 698
+ LT T+V V+W + P ++GYR++Y S + S +D K +
Sbjct: 1731 KFSE---LTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLK 1787
Query: 699 LVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISV 758
+ +L +GVTY ++R + + T E AP P + V S++I++
Sbjct: 1788 VKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIV-----RYSSAIAI 1842
Query: 759 SWDPPPPDHQNGIIQEYKIWCLGNETRF------HINKTVDAAIRSVIIGGLFPGIQYRV 812
W P G I Y I ++ I K V + S+ I L PG+ Y
Sbjct: 1843 HWSSGDPG--KGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDI--LKPGVSYDF 1898
Query: 813 EVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVI 872
V A G G S P ++ V + N E+ +V + + G +++
Sbjct: 1899 RVIAVNDYGFGTPSSP--------SQSVPAQKANPFYEEWWFLV-----VIALVGLIFIL 1945
Query: 873 LMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATS 932
L+ F + + + KK YA G+ +++ + S+P +
Sbjct: 1946 LLVFVLIIRGQSKK------YAKKTDSGNSAKSGALGHSEMMSLDESSFP---------A 1990
Query: 933 LPVNN-----SNSGPNEIGNFGRGDVLPPVPGQG-----DKTATMLSDGAIYSSIDFTTK 982
L +NN NS + G + R PP P G D+ T +D S T K
Sbjct: 1991 LELNNRRLSVKNSFCRKNGLYTRS---PPRPSPGSLHYSDEDVTKYNDLIPAESSSLTEK 2047
Query: 983 TSYNSSSQITQATPYATT--QILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQ 1040
S S SQ + + + Q HS H ++ W+ + + + Y+ D
Sbjct: 2048 PSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRAQAYSYTESDS 2107
Query: 1041 NKGNNGGKGGKKKKNKNS-SKPQKNNGSTWANVPLPP--------PPVQPLPGT 1085
+ ++ + S +P+ + T N P PP PP PG+
Sbjct: 2108 GEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPGS 2161
Score = 58.9 bits (141), Expect = 3e-08
Identities = 114/524 (21%), Positives = 191/524 (36%), Gaps = 69/524 (13%)
Query: 345 VFWQKEGSQNLLFPNQ--PQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTV-AGSIL 401
V WQ+ G +N + + +R + T L ++ G T+ ++
Sbjct: 913 VSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMT 972
Query: 402 AKAQLEVT-DVLTDRPPPIILQGPANQTLAVDG--TALLKCKATGDPLPVIS-WLKE--- 454
+K Q +V+ ++ PP + P N ++ G + L+ + D IS WL E
Sbjct: 973 SKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQV 1032
Query: 455 GFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISK 514
G G + Q +++ + D +TC + +++ +
Sbjct: 1033 GVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQ-------VNIVGTSPPSQP 1085
Query: 515 NYDLSDLPGPP----SKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQT 570
+ + L PP + + ++ S+ L W P LP Y S +
Sbjct: 1086 SRKIQTLQAPPDMAPANVSLRTASETSLWLRWMP-----LPEMEYNGNPESVGYKIKYSR 1140
Query: 571 VANHVKTTL----------YTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 620
H KT YT+ L T Y V+A N G S P + RT++ S
Sbjct: 1141 SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRE-SV 1198
Query: 621 PAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT----VDRQPQFIQGYRVMYRQTS 676
P+ G + + T +++ V W+ DR + GY+VMY++
Sbjct: 1199 PSSGPTNVSA--------------LATTSSSMLVRWSEVPEADRNG-LVLGYKVMYKEKD 1243
Query: 677 GLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAP 736
W + + RSA L L K V YE++V + G S + T +
Sbjct: 1244 SDTQPRFWL---VEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDV 1300
Query: 737 SAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDA-- 794
PP + V +TS+ + W PP NGII Y+I N T + TV+
Sbjct: 1301 PGPPMGILFPEV---RTTSVRLIWQPPAA--PNGIILAYQITHRLNTTTAN-TATVEVLA 1354
Query: 795 -AIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRN 837
+ R GL P Y + A T G G +E + +R+
Sbjct: 1355 PSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRD 1398
Score = 50.8 bits (120), Expect = 9e-06
Identities = 31/103 (30%), Positives = 48/103 (46%), Gaps = 6/103 (5%)
Query: 522 PGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSW----QTVANHVKT 577
PGPP P + + +++ + W G PG P + Y+IEA S W + + V +
Sbjct: 1825 PGPPGVPIIVRYS-SAIAIHWSSGDPGKGPITRYVIEA-RPSDEGLWDILIKDIPKEVSS 1882
Query: 578 TLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 620
+++ L+P Y F V A+N G PS S V Q +P
Sbjct: 1883 YTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 213 bits (543), Expect = 8e-55
Identities = 148/483 (30%), Positives = 224/483 (46%), Gaps = 28/483 (5%)
Query: 26 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL 85
Q PP I P+++ V TTL C+A G P P+I W K+G + D++ S+R LL
Sbjct: 3799 QVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ-NSYR-LL 3856
Query: 86 PSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA 145
SGSL + S D +Y C N G+ R L V + PTD +V
Sbjct: 3857 SSGSLVIIS-----PSVDDTATYECTVTNGAGDD-KRTVDLTVQV-PPSIADEPTDFLVT 3909
Query: 146 AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGMYTCV 204
PA++ C G P P+I+W K+ +R+ + + I G + I T+ + AG YTCV
Sbjct: 3910 KHAPAVITCTAS-GVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV 3968
Query: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 264
N G L V E P +P V+ + C+ G P P + W+K+ +
Sbjct: 3969 ARNAAGSAHRH-VTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGIN 4027
Query: 265 L-PRGR-YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRD 322
+ GR + + L+I + + D GTYMC+A+N G L V+ PP ++
Sbjct: 4028 VNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKE 4087
Query: 323 QIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQ 382
++A + +T CE G P P + W K+G + + R V +G L I +Q
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIV--------ESIRQRVLSSGSLQIAFVQ 4139
Query: 383 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKAT 442
DAG+Y C A VAGS +L V PP I + T+ + A+L C A
Sbjct: 4140 PGDAGHYTCMAANVAGSSSTSTKLTV------HVPPRIRSTEGHYTVNENSQAILPCVAD 4193
Query: 443 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAV 502
G P P I+W K+ + T + G L ++N+ + D+G YTCVA +++GE + +
Sbjct: 4194 GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVS 4253
Query: 503 LDV 505
L V
Sbjct: 4254 LTV 4256
Score = 203 bits (517), Expect = 8e-52
Identities = 145/468 (30%), Positives = 211/468 (45%), Gaps = 31/468 (6%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I H + +++ +P TL+C+A+G P P I W+KDG + + +L SGS
Sbjct: 4078 PPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES-----IRQRVLSSGS 4132
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
L + G D G Y C+A N G + S + L V + R V
Sbjct: 4133 LQIAFVQPG-----DAGHYTCMAANVAGSS-STSTKLTVHV-PPRIRSTEGHYTVNENSQ 4185
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTNM 208
AIL C G P P I WKKD V + + + + G+L++ N D+G YTCV N
Sbjct: 4186 AILPCVAD-GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNA 4244
Query: 209 VGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG 268
GE D+ LTV PTF P + + + E + C+ G P P + W ++ +P
Sbjct: 4245 AGE-DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAH 4303
Query: 269 RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR-PRDQIVAQ 327
+ L I++ D GTY+C AEN VG ++A + V+ PP F P + I
Sbjct: 4304 FDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPL 4363
Query: 328 GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 387
G CE KG+P P + W ++G + Q N G L I DAG
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGN--------GSLAIYGTVNEDAG 4415
Query: 388 YYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP 447
Y C A AG + E + LT + PPII P + G +L C+ATG+P P
Sbjct: 4416 DYTCVATNEAGVV------ERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQP 4469
Query: 448 VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
I+W ++G + D R + +L I + + DT + CVA + G
Sbjct: 4470 TITWSRQGHSI-SWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMG 4516
Score = 198 bits (504), Expect = 3e-50
Identities = 144/489 (29%), Positives = 209/489 (42%), Gaps = 31/489 (6%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP ++ P+DV + G TL C +G P PTI+W + + S L +G+
Sbjct: 792 PPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA 851
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
LF L + D+G+Y+C A N G+ S L+ +P+ V G+
Sbjct: 852 LFILNLWAS-----DKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQ 906
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTNM 208
L C G+P P W K+ + + I++R G L I + D G YTCV +N+
Sbjct: 907 LTLPCTLLAGNPIPERRWIKNSAMLL-QNPYITVRSDGSLHIERVQLQDGGEYTCVASNV 965
Query: 209 VGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA--DLP 266
G + + + V PT +E V C+ G+P+P+V W K
Sbjct: 966 AGTNNKTTS-VVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTS 1024
Query: 267 RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV-------- 318
++ D +L + + G Y+C A N G + LTV P+
Sbjct: 1025 SAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQD 1084
Query: 319 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
+P + V G VT PCE K P P + W KE L+ P P R + P+G + I
Sbjct: 1085 KPVEISVLAGEEVTLPCEVKSLPPPIITWAKE--TQLISPFSP-----RHTFLPSGSMKI 1137
Query: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLK 438
T + SD+G Y+C A +AG++ +L V PP I +GP + + V +
Sbjct: 1138 TETRTSDSGMYLCVATNIAGNVTQAVKLNV------HVPPKIQRGPKHLKVQVGQRVDIP 1191
Query: 439 CKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETS 498
C A G PLPVI+W K G T GTL I SD G YTCVAT+ +G
Sbjct: 1192 CNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE 1251
Query: 499 WSAVLDVTE 507
L V E
Sbjct: 1252 TEITLHVQE 1260
Score = 178 bits (452), Expect = 3e-44
Identities = 141/481 (29%), Positives = 209/481 (43%), Gaps = 45/481 (9%)
Query: 36 HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95
HP+++IV++G+ +L C+ +G P PT+ W KDG + K +L G + L+
Sbjct: 2298 HPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE-----ILDEGHILQLKN 2352
Query: 96 VHGRRSKPDEGSYVCVARNYLGEAVSR-NASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
+H D G YVCVA N G + + S+ ++P ++ V L C
Sbjct: 2353 IH----VSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 155 QPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLM-ISNTRKSDAGMYTCVGTNMVGERD 213
+ G P P+I W KD + + GG+++ + T DAG YTCV N GE +
Sbjct: 2409 EAS-GIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE-E 2466
Query: 214 SDPAELTVFERPTFL-RRPINQV-VLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR--GR 269
L+V P + + V V E+++V C+V G+P P + W KD L
Sbjct: 2467 RKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAH 2526
Query: 270 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV-----RPRDQI 324
+ I L+I G Y C+A + G S +L V P P D
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG-DLTITNIQR 383
V + CE P + W K+G+ P + N + P G L I N Q
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITWFKDGT--------PLESNRNIRILPGGRTLQILNAQE 2638
Query: 384 SDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQG--------PANQTLAVDGTA 435
+AG Y C A AG ++ +++V PPII +G P + V+ T
Sbjct: 2639 DNAGRYSCVATNEAGEMIKHYEVKVYI------PPIINKGDLWGPGLSPKEVKIKVNNTL 2692
Query: 436 LLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
L+C+A P +SW K+G D TLQIK +ISDTG YTCVA++ +G
Sbjct: 2693 TLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG 2752
Query: 496 E 496
E
Sbjct: 2753 E 2753
Score = 178 bits (451), Expect = 4e-44
Identities = 145/524 (27%), Positives = 225/524 (42%), Gaps = 52/524 (9%)
Query: 30 PPRIV--EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I + S IV L+C G P PTI W KDG+ + D R +L +
Sbjct: 1732 PPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLI-----DERDGFKILLN 1786
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
G ++V + + G Y C+A N G+ + + V + ++ VV
Sbjct: 1787 GR----KLVIAQAQVSNTGLYRCMAANTAGDH-KKEFEVTVHVPPTIKSSGLSERVVVKY 1841
Query: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR--GGKLMISNTRKSDAGMYTCVG 205
+P L+C G P P+I W KD ++ + + I+ G L I+ T DAG YTCV
Sbjct: 1842 KPVALQCIA-NGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVA 1900
Query: 206 TNMVGERDSDPAELTVFERPTF--LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 263
TN GE +L V E P+ + +N+ VL V+ C+ G+P P + W KD+
Sbjct: 1901 TNAAGETQQH-IQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNR 1959
Query: 264 DLP--RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPR 321
L + + I+ +D G Y C+A N G E +L V P
Sbjct: 1960 LLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNN 2019
Query: 322 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 381
V V CE +G P P++ W K+GS F N Q +S L +T+
Sbjct: 2020 MVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQV------LSGGRILALTSA 2073
Query: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 441
Q SD G Y C A+ AG L V PP I+ N ++ + L C++
Sbjct: 2074 QISDTGRYTCVAVNAAGEKQRDIDLRVY------VPPNIMGEEQNVSVLISQAVELLCQS 2127
Query: 442 TGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSA 501
P P ++WLK+G + + + + L+I++ ++ DTG YTC AT+ +G+T
Sbjct: 2128 DAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKT---- 2183
Query: 502 VLDVTESGATISKNYDLS-----DLPGPPSKPQVTDVTKNSVTL 540
KNY+++ ++ G Q+T + N ++L
Sbjct: 2184 -----------EKNYNVNIWVPPNIGGSDELTQLTVIEGNLISL 2216
Score = 177 bits (450), Expect = 5e-44
Identities = 145/502 (28%), Positives = 215/502 (42%), Gaps = 44/502 (8%)
Query: 34 VEHPSDVIVS-KGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFF 92
++H ++ + +G P TL CKA G P P++ W K GE + T + GSL+
Sbjct: 983 IQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGA----DGSLYV 1038
Query: 93 LRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDF-------RQNPTDVVVA 145
+ + G YVC A N G A R L V + F + P ++ V
Sbjct: 1039 VS-----PGGEESGEYVCTATNTAGYA-KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVL 1092
Query: 146 AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCV 204
AGE L C+ + P P I W K+ I R + + G + I+ TR SD+GMY CV
Sbjct: 1093 AGEEVTLPCEV-KSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCV 1151
Query: 205 GTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 264
TN+ G + +L V P R P + V + V+ C QG P P + W K +
Sbjct: 1152 ATNIAGNV-TQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGST 1210
Query: 265 -LPRGRYDIKD-DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFV-VRPR 321
L G + + + D TL I + +D G Y C+A N G E TL V+ PP + P
Sbjct: 1211 MLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPP 1270
Query: 322 DQIVAQGRT----VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL- 376
Q R + FPC KG P+P + W G + L +P S+ G L
Sbjct: 1271 YNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRE--LTGREPG-----ISILEDGTLL 1323
Query: 377 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIIL--QGPANQTLAVDGT 434
I ++ D G YIC A+ AG+ K L+V PP+I + N ++ ++
Sbjct: 1324 VIASVTPYDNGEYICVAVNEAGTTERKYNLKV------HVPPVIKDKEQVTNVSVLLNQL 1377
Query: 435 ALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS 494
L C+ G P P+I W K+ T+ L++ D G Y+C A + +
Sbjct: 1378 TNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIA 1437
Query: 495 GETSWSAVLDVTESGATISKNY 516
G + +DV I N+
Sbjct: 1438 GTSQKYFNIDVLVPPTIIGTNF 1459
Score = 176 bits (446), Expect = 1e-43
Identities = 157/561 (27%), Positives = 244/561 (43%), Gaps = 61/561 (10%)
Query: 17 VRVDGSRLRQEDF----PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 72
V G + R D PP I+ +V V + L C+++ P PT+ W KDG
Sbjct: 2086 VNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDG---- 2141
Query: 73 TDKDDPRSHRMLLPSGSLFFLRIVHGRR-------SKPDEGSYVCVARNYLGEAVSRNAS 125
H +L G L I R D G Y C A N G+ +N +
Sbjct: 2142 --------HPLLKKPG----LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKT-EKNYN 2188
Query: 126 LEVALLRDDFRQNP-TDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRI-DDKEERISI 183
+ + + + + T + V G L C+ G P P + WKK + D R+ I
Sbjct: 2189 VNIWVPPNIGGSDELTQLTVIEGNLISLLCESS-GIPPPNLIWKKKGSPVLTDSMGRVRI 2247
Query: 184 RGG--KLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLR---RPINQVVLE 238
G +L IS KSDA +Y+CV +N+ G + L V+ RPT P +V
Sbjct: 2248 LSGGRQLQISIAEKSDAALYSCVASNVAGTAKKE-YNLQVYIRPTITNSGSHPTEIIVTR 2306
Query: 239 EEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIKDD-YTLRIKKTMSTDEGTYMCIAE 296
+++ C+VQG P PTV W KD L + + +I D+ + L++K +D G Y+C+A
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAV 2366
Query: 297 NRVGKMEASATLTVRAPPQFVVR---PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQ 353
N G + L+V APP + P + V + +V+ CE G P P++ W K+G
Sbjct: 2367 NVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWP 2426
Query: 354 NLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413
L NS +S L + DAG Y C AG + ++ +
Sbjct: 2427 VSL-------SNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE-----ERKIFGLSV 2474
Query: 414 DRPPPIILQGPANQTLAVDGTAL-LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT 472
PP I+ + + ++ L C+ TG+P+P I+W K+G + I
Sbjct: 2475 LVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRF 2534
Query: 473 LQIKNLRISDTGTYTCVATSSSGETSWSAVLDV----TESGATISKN-YDLSDLPGPPSK 527
LQI N+++ TG YTC+A+S +G S S L+V T +G N D++ + P+
Sbjct: 2535 LQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS 2594
Query: 528 PQVTDVTKNSVTLSW-QPGTP 547
+ T++W + GTP
Sbjct: 2595 LVCEAYSYPPATITWFKDGTP 2615
Score = 174 bits (441), Expect = 5e-43
Identities = 139/483 (28%), Positives = 205/483 (42%), Gaps = 41/483 (8%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKA-EGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
P I PS V +G+ TL C G P P W K+ + + + + GS
Sbjct: 890 PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNP-----YITVRSDGS 944
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
L R+ D G Y CVA N G ++ S+ V +L + + G P
Sbjct: 945 LHIERV-----QLQDGGEYTCVASNVAGTN-NKTTSVVVHVL-PTIQHGQQILSTIEGIP 997
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTNM 208
L C+ G+P+P++ W K I + S G L + + ++G Y C TN
Sbjct: 998 VTLPCKAS-GNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNT 1056
Query: 209 VGERDSDPAELTVFERPTFLR--------RPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
G +LTV+ RP +P+ VL E V C+V+ P P + W K
Sbjct: 1057 AGYAKRK-VQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAK 1115
Query: 261 DDADLP--RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 318
+ + R+ +++I +T ++D G Y+C+A N G + + L V PP+
Sbjct: 1116 ETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQR 1175
Query: 319 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
P+ V G+ V PC +G P P + W K GS +L + N P G L+I
Sbjct: 1176 GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGS-TMLVDGEHHVSN------PDGTLSI 1228
Query: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL---AVDGTA 435
SDAG Y C A +AG+ + E+T + + P L+ P N T +
Sbjct: 1229 DQATPSDAGIYTCVATNIAGT----DETEITLHVQEPPTVEDLEPPYNTTFQERVANQRI 1284
Query: 436 LLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT-LQIKNLRISDTGTYTCVATSSS 494
C A G P P I WL G GR+P +I E GT L I ++ D G Y CVA + +
Sbjct: 1285 EFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEA 1344
Query: 495 GET 497
G T
Sbjct: 1345 GTT 1347
Score = 174 bits (441), Expect = 5e-43
Identities = 138/469 (29%), Positives = 206/469 (43%), Gaps = 42/469 (8%)
Query: 52 CKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCV 111
C A+G P PTI+W +G + T ++ S +L G+L + V + D G Y+CV
Sbjct: 1288 CPAKGTPKPTIKWLHNGREL-TGREPGIS---ILEDGTLLVIASV----TPYDNGEYICV 1339
Query: 112 ARNYLGEAVSRNASLEV---ALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWK 168
A N G R +L+V +++D ++ T+V V + L C+ G P P I W
Sbjct: 1340 AVNEAG-TTERKYNLKVHVPPVIKD--KEQVTNVSVLLNQLTNLFCEV-EGTPSPIIMWY 1395
Query: 169 KDKVRIDDKEERISIRGGKLM-ISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTF 227
KD V++ + ++ GK++ + DAG Y+C N+ G + V PT
Sbjct: 1396 KDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKY-FNIDVLVPPTI 1454
Query: 228 LRR--PINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK---DDYTLRIKK 282
+ P V+ V CQV+G P P + W KD L G +++ L +K
Sbjct: 1455 IGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKN 1514
Query: 283 TMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR--PRDQIVAQGRTVTFPCETKGN 340
D+G Y C N GK LT+ PP D V + CET+G
Sbjct: 1515 ARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGL 1574
Query: 341 PQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYICQALTVAGS 399
P PA+ W K+G QP +S+ G L I Q SD+ Y C VAG+
Sbjct: 1575 PMPAITWYKDG--------QPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGT 1626
Query: 400 ILAKAQLEVTDVLTDRPPPII---LQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGF 456
++V PP+I L P N+ + + + L+CKA G+P P+++WLK+G
Sbjct: 1627 AEKSFHVDVY------VPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGV 1680
Query: 457 TFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
D L+I + + D G Y CVATS +GE +DV
Sbjct: 1681 PVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDV 1729
Score = 172 bits (437), Expect = 2e-42
Identities = 140/483 (28%), Positives = 199/483 (41%), Gaps = 27/483 (5%)
Query: 30 PPRI--VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I E ++ V P L C A G P P + W KDG + P++ ++
Sbjct: 3526 PPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPL------PQTDQVQTLG 3579
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
G LRI D G Y C+A + G+ P D+ V
Sbjct: 3580 GGEV-LRI--STAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRN 3636
Query: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTCVGT 206
LEC+ P P I W ++ R+ + GG+ L I+N D YTCV +
Sbjct: 3637 RQVTLECKSD-AVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVAS 3695
Query: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP 266
N+ G+ + LTV P P + V+L ++ C +G P P + W+KD A L
Sbjct: 3696 NIAGKTTREFI-LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA 3754
Query: 267 --RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
RY I ++ L I+ TD G Y+C+A N G L V PP P +
Sbjct: 3755 GNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMT 3814
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS 384
V T CE G P+P++ W+K G +LL N Q NS +S +G L I +
Sbjct: 3815 VIVNVQTTLACEATGIPKPSINWRKNG--HLL--NVDQNQNSYRLLS-SGSLVIISPSVD 3869
Query: 385 DAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGD 444
D Y C AG + T LT + PP I P + + A++ C A+G
Sbjct: 3870 DTATYECTVTNGAGDD------KRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGV 3923
Query: 445 PLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLD 504
P P I W K G R I G ++I +++ G YTCVA +++G L
Sbjct: 3924 PFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLH 3983
Query: 505 VTE 507
V E
Sbjct: 3984 VHE 3986
Score = 172 bits (435), Expect = 3e-42
Identities = 135/468 (28%), Positives = 201/468 (42%), Gaps = 30/468 (6%)
Query: 38 SDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 97
+D+ V L C+ G P P I WYKDG+ + + S + + G +L I
Sbjct: 1555 TDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSS-----SQALYIDKGQ--YLHIPR 1607
Query: 98 GRRSKPDEGSYVCVARNYLGEAV-SRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQP 156
+ S D +Y C N G A S + + V + + P + V LEC+
Sbjct: 1608 AQVS--DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKA 1665
Query: 157 PRGHPEPTIYWKKDKVRIDDKEE-RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 215
G+P P + W KD V + + RI G KL I + ++ D G Y CV T++ GE++
Sbjct: 1666 A-GNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK 1724
Query: 216 PAELTVFERPTFLRRPINQ--VVLEEEAVEFRCQVQGDPQPTVRWKKDDA--DLPRGRYD 271
E+ V P +V+ +E C V G P PT+ W KD D G
Sbjct: 1725 -YEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKI 1783
Query: 272 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP-RDQIVAQGRT 330
+ + L I + ++ G Y C+A N G + +TV PP +++V + +
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKP 1843
Query: 331 VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYI 390
V C G P P++ W K+ P Q N + S L I DAG Y
Sbjct: 1844 VALQCIANGIPNPSITWLKDDQ-----PVNTAQGNLKIQSSGRV-LQIAKTLLEDAGRYT 1897
Query: 391 CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA-NQTLAVDGTALLKCKATGDPLPVI 449
C A AG QL V + PP + G N+T+ V L+CKA G+P+PVI
Sbjct: 1898 CVATNAAGETQQHIQLHVHE-----PPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVI 1952
Query: 450 SWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
+W K+ G + + I++ +ISD G Y CVA +S+G T
Sbjct: 1953 TWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGAT 2000
Score = 171 bits (432), Expect = 6e-42
Identities = 152/548 (27%), Positives = 235/548 (42%), Gaps = 75/548 (13%)
Query: 30 PPRIVEHPS--DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP IV + DV V + + TL C+ G P P I W+KDG+ ++ D+ +H ++ S
Sbjct: 2477 PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE----AHHII--S 2530
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV----ALLRDDFRQNPTDVV 143
G F L+I + + P G Y C+A + G SR+ SL V + NP DV
Sbjct: 2531 GGRF-LQITNVQ--VPHTGRYTCLASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVT 2586
Query: 144 VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYT 202
V P L C+ +P TI W KD ++ + GG+ L I N ++ +AG Y+
Sbjct: 2587 VILNSPTSLVCEA-YSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYS 2645
Query: 203 CVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFR--------CQVQGDPQP 254
CV TN GE E+ V+ P + + L + V+ + C+ P
Sbjct: 2646 CVATNEAGEMIKH-YEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSA 2704
Query: 255 TVRWKKDDADLPRGRYD--IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA 312
++ W KD L + + +TL+IK+ +D G Y C+A N G+ E + ++
Sbjct: 2705 SLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQV 2764
Query: 313 PPQFVV--------------RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 358
PP F +D I+ ++ CET P P + W K+G
Sbjct: 2765 PPSFQKLWEIGNMLDTGRNGEAKDVII--NNPISLYCETNAAPPPTLTWYKDG------- 2815
Query: 359 NQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPP 417
P + + + P G L I + DAG Y C A+ AG + + V P
Sbjct: 2816 -HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL------VP 2868
Query: 418 PIILQG----PANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTL 473
PII P T+ V+ +AL++C ++G P P SW K+G D + L
Sbjct: 2869 PIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRIL 2928
Query: 474 QIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDV 533
QI N +I+D G Y CVA +++G L+V + I P +T V
Sbjct: 2929 QILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIG-----------PKSENLTVV 2977
Query: 534 TKNSVTLS 541
N ++L+
Sbjct: 2978 VNNFISLT 2985
Score = 170 bits (430), Expect = 1e-41
Identities = 133/455 (29%), Positives = 197/455 (43%), Gaps = 35/455 (7%)
Query: 50 LNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYV 109
+ C+A G P P I W K+G + SH LL +G + +RIV + S D Y
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLS-----SHIRLLAAGQV--IRIVRAQVS--DVAVYT 3412
Query: 110 CVARNYLGEAVSRNASLEV-ALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWK 168
CVA N G +++ +L+V A D ++ V G + C G P P++ W
Sbjct: 3413 CVASNRAG-VDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITD-GTPAPSMAWL 3470
Query: 169 KDKVRID-DKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTF 227
+D + D +S G L + D+G YTC+ +N GE S L V E P
Sbjct: 3471 RDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEV-SKHFILKVLEPPHI 3529
Query: 228 LRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRY--DIKDDYTLRIKKT 283
++ V+ +E C G P P + W KD LP+ + LRI
Sbjct: 3530 NGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTA 3589
Query: 284 MSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV--RPRDQIVAQGRTVTFPCETKGNP 341
D G Y C+A + G + + V PP PRD V + R VT C++ P
Sbjct: 3590 QVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVP 3649
Query: 342 QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSI 400
P + W + G + Q R + G L I N D Y C A +AG
Sbjct: 3650 PPVITWLRNGER--------LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKT 3701
Query: 401 LAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPG 460
+ +LT PP I GP + + ++ + +L+C A G P P I+W K+G G
Sbjct: 3702 TREF------ILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAG 3755
Query: 461 RDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
R +I E G L I++ ++DTG Y C+AT+++G
Sbjct: 3756 NHARYSILENGFLHIQSAHVTDTGRYLCMATNAAG 3790
Score = 169 bits (429), Expect = 1e-41
Identities = 135/478 (28%), Positives = 206/478 (43%), Gaps = 41/478 (8%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP +++ P++V V+ GE L C + W ++ V +P R L + S
Sbjct: 519 PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLA--EPARIRTLA-NLS 575
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV----- 144
L + D G Y C+ + E S AS+ + + Q P V V
Sbjct: 576 LELKSVKFN-----DAGEYHCMVSS---EGGSSAASVFLTV------QEPPKVTVMPKNQ 621
Query: 145 --AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYT 202
G + C G+P+P I W + + I G L I N DAG+Y
Sbjct: 622 SFTGGSEVSIMCSAT-GYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYG 680
Query: 203 CVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD 262
C+ +N G D + L E P + +V + C+ G P P V+W K D
Sbjct: 681 CLASNSAGT-DKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGD 739
Query: 263 ADLPRGRYDIKDDYT--LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
+L + I D L+I++T D G Y C+A N G+ TL V +PP F+ P
Sbjct: 740 LELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEP 799
Query: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP--TGDLTI 378
D + G VT PC +G P+P + W++ + + +P S S+S TG L I
Sbjct: 800 ADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIF-----SRPFSVSSISQLRTGALFI 854
Query: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLK 438
N+ SD G YIC+A G K Q E T +T P+I P+ + L
Sbjct: 855 LNLWASDKGTYICEAENQFG----KIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLP 910
Query: 439 CK-ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
C G+P+P W+K ++P T++ G+L I+ +++ D G YTCVA++ +G
Sbjct: 911 CTLLAGNPIPERRWIKNSAMLL-QNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAG 967
Score = 169 bits (429), Expect = 1e-41
Identities = 140/474 (29%), Positives = 213/474 (44%), Gaps = 45/474 (9%)
Query: 39 DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHG 98
DVI++ P +L C+ P PT+ WYKDG + T D ++LP G R++
Sbjct: 2788 DVIINN--PISLYCETNAAPPPTLTWYKDGHPL-TSSDKV----LILPGG-----RVLQI 2835
Query: 99 RRSK-PDEGSYVCVARNYLGE-AVSRNASLEVA-LLRDDFRQNPTDVVVAAGEPAILECQ 155
R+K D G Y CVA N GE ++ + + V +++ P +V V + A++EC
Sbjct: 2836 PRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECL 2895
Query: 156 PPRGHPEPTIYWKKD-KVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
G P P W+KD + ++D + G L I NT+ +D G Y CV N G
Sbjct: 2896 SS-GSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKK 2954
Query: 215 DPAELTVFERPTFLR-RPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD--LPRGRYD 271
L V P+ + + N V+ + C+V G P P + W K++ L
Sbjct: 2955 Y-FNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLI 3013
Query: 272 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI----VAQ 327
+ TL+I + +D G Y CIA N+ G+ + +LTV PP + + V +
Sbjct: 3014 VPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVRE 3073
Query: 328 GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDA 386
G +V+ CE+ P P + W K G + ++ + G L I + SD
Sbjct: 3074 GTSVSLECESNAVPPPVITWYKNG--------RMITESTHVEILADGQMLHIKKAEVSDT 3125
Query: 387 GYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL--AVDGTALLKCKATGD 444
G Y+C+A+ VAG L V PP I +GP + + + L C ATG
Sbjct: 3126 GQYVCRAINVAGRDDKNFHLNVY-----VPPSI--EGPEREVIVETISNPVTLTCDATGI 3178
Query: 445 PLPVISWLKEGFTFPGRDP-RATIQEQGT-LQIKNLRISDTGTYTCVATSSSGE 496
P P I+WLK D I G+ LQI + SD+G YTC+A++ G+
Sbjct: 3179 PPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGK 3232
Score = 166 bits (421), Expect = 1e-40
Identities = 139/495 (28%), Positives = 208/495 (42%), Gaps = 64/495 (12%)
Query: 36 HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95
+P DV V PT+L C+A P TI W+KDG +E++++ +LP G L+I
Sbjct: 2581 NPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNI-----RILPGGRT--LQI 2633
Query: 96 VHGRRSKPDEGSYVCVARNYLGEAVSR---NASLEVALLRDDF---RQNPTDVVVAAGEP 149
++ + + G Y CVA N GE + + + + D +P +V +
Sbjct: 2634 LNAQED--NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNT 2691
Query: 150 AILECQPPRGHPEPTIYWKKDKVRI-DDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 208
LEC+ P ++ W KD + D I+ G L I + SD G YTCV +N+
Sbjct: 2692 LTLECEA-YAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNI 2750
Query: 209 VGERDSD--------PAELTVFERPTFLRRPIN---QVVLEEEAVEFRCQVQGDPQPTVR 257
GE + D P+ ++E L N + V+ + C+ P PT+
Sbjct: 2751 AGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLT 2810
Query: 258 WKKDDADL---------PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL 308
W KD L P GR L+I + D G Y C+A N G+ +
Sbjct: 2811 WYKDGHPLTSSDKVLILPGGR-------VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDV 2863
Query: 309 TVRAPPQFVVR------PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 362
V PP +++ P + V ++ C + G+P P WQK+G L +
Sbjct: 2864 RVLVPP--IIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKF 2921
Query: 363 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422
N R L I N Q +D G Y+C A AGS L V PP +I
Sbjct: 2922 LSNGRI-------LQILNTQITDIGRYVCVAENTAGSAKKYFNLNV-----HVPPSVIGP 2969
Query: 423 GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISD 482
N T+ V+ L C+ +G P P +SWLK + TLQI ++SD
Sbjct: 2970 KSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSD 3029
Query: 483 TGTYTCVATSSSGET 497
G YTC+A + +GE+
Sbjct: 3030 GGEYTCIAINQAGES 3044
Score = 164 bits (416), Expect = 4e-40
Identities = 140/497 (28%), Positives = 205/497 (41%), Gaps = 45/497 (9%)
Query: 30 PPRIVEHPSD----VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL 85
PP I +H S+ V V +G +L C++ P P I WYK+G + +H +L
Sbjct: 3055 PPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITES-----THVEIL 3109
Query: 86 PSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA 145
G + ++ + D G YVC A N G +N L V + +V
Sbjct: 3110 ADGQMLHIK----KAEVSDTGQYVCRAINVAGRD-DKNFHLNVYVPPSIEGPEREVIVET 3164
Query: 146 AGEPAILECQPPRGHPEPTIYWKKDKVRI---DDKEERISIRGGKLMISNTRKSDAGMYT 202
P L C G P PTI W K+ RI D E RI G KL I+ ++ SD+G YT
Sbjct: 3165 ISNPVTLTCDAT-GIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYT 3223
Query: 203 CVGTNMVGERDSDP-AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 261
C+ +NM G+ + V P + VL E VE C G P P ++W KD
Sbjct: 3224 CIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKD 3283
Query: 262 DADLPRGRYD----IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFV 317
+ G + + TL I +++D G Y C+A N G+ + L V P +
Sbjct: 3284 GKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPT-I 3342
Query: 318 VRPRDQ----IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
+D+ + ++ C G P P + W K G P +S +
Sbjct: 3343 RGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNG--------LPLPLSSHIRLLAA 3394
Query: 374 GD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPI-ILQGPANQTLAV 431
G + I Q SD Y C A AG L+V PP + G T+
Sbjct: 3395 GQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF-----APPNMDNSMGTEEITVLK 3449
Query: 432 DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQG-TLQIKNLRISDTGTYTCVA 490
+ + C G P P ++WL++G G D T+ G LQ+ D+G YTC+A
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDGQPL-GLDAHLTVSTHGMVLQLLKAETEDSGKYTCIA 3508
Query: 491 TSSSGETSWSAVLDVTE 507
++ +GE S +L V E
Sbjct: 3509 SNEAGEVSKHFILKVLE 3525
Score = 158 bits (399), Expect = 4e-38
Identities = 135/491 (27%), Positives = 200/491 (40%), Gaps = 40/491 (8%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP+I P + V G+ + C A+G P P I W K G + D + H + P G+
Sbjct: 1170 PPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE----HHVSNPDGT 1225
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLG-EAVSRNASLEVALLRDDFRQ--NPTDVVVAA 146
L + + D G Y CVA N G + ++ +D N T A
Sbjct: 1226 LSI-----DQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVA 1280
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR--GGKLMISNTRKSDAGMYTCV 204
+ C P +G P+PTI W + + +E ISI G L+I++ D G Y CV
Sbjct: 1281 NQRIEFPC-PAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICV 1339
Query: 205 GTNMVGERDSDPAELTVFERPTFLRRP--INQVVLEEEAVEFRCQVQGDPQPTVRWKKDD 262
N G + L V P + N VL + C+V+G P P + W KD+
Sbjct: 1340 AVNEAGTTERK-YNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDN 1398
Query: 263 ADLPRGR--YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR- 319
+ + + L++ + D G Y C A N G + + V PP +
Sbjct: 1399 VQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTN 1458
Query: 320 -PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LT 377
P + V R V C+ KG P P + W K+G LF P + G L
Sbjct: 1459 FPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP--LFLGDPN-----VELLDRGQVLH 1511
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDV-LTDRPPPIILQGPANQTLAVDGTAL 436
+ N +R+D G Y C AG + D+ LT PP I G ++V +L
Sbjct: 1512 LKNARRNDKGRYQCTVSNAAGK-------QAKDIKLTIYIPPSIKGGNVTTDISVLINSL 1564
Query: 437 LK--CKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS 494
+K C+ G P+P I+W K+G I + L I ++SD+ TYTC + +
Sbjct: 1565 IKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVA 1624
Query: 495 GETSWSAVLDV 505
G S +DV
Sbjct: 1625 GTAEKSFHVDV 1635
Score = 152 bits (385), Expect = 2e-36
Identities = 144/498 (28%), Positives = 206/498 (41%), Gaps = 54/498 (10%)
Query: 30 PPRIV--EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP + E PSDV V GE L C A G PTP I+W KDG+ + + + + + S
Sbjct: 3244 PPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETE-----RIRVS 3298
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTD---VVV 144
+ L I S D G Y CVA N GE R +L V + R N + ++
Sbjct: 3299 ANGSTLNIYGALTS--DTGKYTCVATNPAGEE-DRIFNLNV-YVTPTIRGNKDEAEKLMT 3354
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRID-DKEERISIRGGKLMISNTRKSDAGMYTC 203
+EC+ G P P I W K+ + + R+ G + I + SD +YTC
Sbjct: 3355 LVDTSINIECR-ATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTC 3413
Query: 204 VGTNMVGERDSDPAELTVFERPTFLRRPINQ--VVLEEEAVEFRCQVQGDPQPTVRWKKD 261
V +N G D+ L VF P + VL+ + C G P P++ W +D
Sbjct: 3414 VASNRAGV-DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 262 ------DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
DA L + + L++ K + D G Y CIA N G++ L V PP
Sbjct: 3473 GQPLGLDAHLTVSTHGM----VLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPH 3528
Query: 316 F--VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
+ V + C G P P + W K+G +P +
Sbjct: 3529 INGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDG--------RPLPQTDQVQTLGG 3580
Query: 374 GD-LTITNIQRSDAGYYICQALTVAG----SILAKAQLEVTDVLTDRPPPIILQGPANQT 428
G+ L I+ Q D G Y C A + AG L + + TD P I T
Sbjct: 3581 GEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDI--------T 3632
Query: 429 LAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGT-LQIKNLRISDTGTYT 487
+ + L+CK+ P PVI+WL+ G PR I G LQI N + DT YT
Sbjct: 3633 VLRNRQVTLECKSDAVPPPVITWLRNGERLQA-TPRVRILSGGRYLQINNADLGDTANYT 3691
Query: 488 CVATSSSGETSWSAVLDV 505
CVA++ +G+T+ +L V
Sbjct: 3692 CVASNIAGKTTREFILTV 3709
Score = 142 bits (357), Expect = 3e-33
Identities = 111/382 (29%), Positives = 166/382 (43%), Gaps = 26/382 (6%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PPRI V++ L C A+G PTP I W KD + + P G
Sbjct: 4168 PPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAE----PYGE 4223
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
L +V D G Y CVA N GE + SL V +L F + P DV + GE
Sbjct: 4224 LILENVV-----LEDSGFYTCVANNAAGED-THTVSLTVHVL-PTFTELPGDVSLNKGEQ 4276
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTNM 208
L C+ G P P + W + I + S+ G +L+I K D+G Y C N
Sbjct: 4277 LRLSCKAT-GIPLPKLTWTFNNNIIPAHFD--SVNGHSELVIERVSKEDSGTYVCTAENS 4333
Query: 209 VGERDSDPAELTVFERPTFLRR-PINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR 267
VG + + V E P F P N + C+V+GDP PT++W + D+
Sbjct: 4334 VGFVKAI-GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEI 4392
Query: 268 G-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA 326
R + +L I T++ D G Y C+A N G +E S +LT+++PP + P + ++
Sbjct: 4393 SHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVIN 4452
Query: 327 QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDA 386
G + C+ G PQP + W ++G + R +V L I + Q+ D
Sbjct: 4453 AGGKIILNCQATGEPQPTITWSRQG--------HSISWDDRVNVLSNNSLYIADAQKEDT 4504
Query: 387 GYYICQALTVAGSILAKAQLEV 408
+ C A + GS+L + + V
Sbjct: 4505 SEFECVARNLMGSVLVRVPVIV 4526
Score = 112 bits (281), Expect = 2e-24
Identities = 90/340 (26%), Positives = 140/340 (41%), Gaps = 28/340 (8%)
Query: 188 LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQ 247
L I+ SD G Y C+ + G + V E P ++ P N V E C
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTF-FDVSEPPPVIQVPNNVTVTPGERAVLTCL 542
Query: 248 VQGDPQPTVRWKKDDADL---PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEA 304
+ + W+++D D+ R + +L +K D G Y C+ + G A
Sbjct: 543 IISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAA 602
Query: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQP 364
S LTV+ PP+ V P++Q G V+ C G P+P + W + N +F
Sbjct: 603 SVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAW----TVNDMFI----VG 654
Query: 365 NSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 424
+ R ++ G L I N DAG Y C A AG+ + L + P ++
Sbjct: 655 SHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEA------PKLMVVQ 708
Query: 425 ANQTLAVDGTALLKCKATGDPLPVISWLKEGF-----TFPGRDPRATIQEQGTLQIKNLR 479
+ +A+ +++CK +G P P + W K TF DP G L+I+ +
Sbjct: 709 SELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL-----GLLKIQETQ 763
Query: 480 ISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLS 519
D G YTCVA + +G + LDV I + D+S
Sbjct: 764 DLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVS 803
Score = 54.7 bits (130), Expect = 6e-07
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 21/145 (14%)
Query: 371 SPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA 430
S + +L I + SD G+Y C A++ AG+ A+ +V++ PPP+I Q P N T+
Sbjct: 479 SASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE-----PPPVI-QVPNNVTVT 532
Query: 431 VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQG--------TLQIKNLRISD 482
A+L C +IS + T+ D + E +L++K+++ +D
Sbjct: 533 PGERAVLTCL-------IISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFND 585
Query: 483 TGTYTCVATSSSGETSWSAVLDVTE 507
G Y C+ +S G ++ S L V E
Sbjct: 586 AGEYHCMVSSEGGSSAASVFLTVQE 610
Score = 37.4 bits (85), Expect = 0.10
Identities = 25/95 (26%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 449 ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTES 508
+S+++ G T G D L I + +SD G Y C+A SS+G DV+E
Sbjct: 461 LSFVRNGVTL-GVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEP 519
Query: 509 GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQ 543
I +++ PG + ++ L+WQ
Sbjct: 520 PPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQ 554
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 211 bits (538), Expect = 3e-54
Identities = 203/753 (26%), Positives = 317/753 (42%), Gaps = 87/753 (11%)
Query: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFR---------QNPTDVVVAAGEPAILEC 154
D G+Y CV + + A + + L D Q P + A G LEC
Sbjct: 190 DVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLEC 249
Query: 155 QPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
G+P P I W++ + ++ G L I N ++ DAG Y C+ N G+ +
Sbjct: 250 FA-LGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVA 308
Query: 215 DPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKD 274
LT + +P +++ + + E+++ + C+ G P+P+ RW K+ A L +
Sbjct: 309 R-GRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIE 367
Query: 275 DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL-TVRAPPQFVVRPRDQI--VAQGRTV 331
+ L I TD G + CIAEN+ G + +SA L V + P F P ++ V G V
Sbjct: 368 NGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLV 427
Query: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYIC 391
+ C+ + +P+ W K+G ++ Q + R S+ G L I N+ ++DAG Y C
Sbjct: 428 SLDCKPRASPRALSSW-KKGDVSV-------QEHERISLLNDGGLKIANVTKADAGTYTC 479
Query: 392 QALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL--PVI 449
A G L VT+ P I P+N ++V + +L C+ DPL +
Sbjct: 480 MAENQFGKANGTTHLVVTE------PTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIF 533
Query: 450 SWLKEGFTFPGRDPRATIQE-----QGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLD 504
+W G + + ++ G L I+N+++ +G Y C+ +G S S+ D
Sbjct: 534 TWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMV--QTGVDSVSSAAD 591
Query: 505 VTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSV 564
+ G+ PGPP +V ++T + LSW+ G P +Y I+A
Sbjct: 592 LIVRGS-----------PGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQA-RTPF 639
Query: 565 SNSWQTVAN-----HVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDIS 619
S WQTV KT TV L P Y F V A N G +PS S+ VRT++
Sbjct: 640 SVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAV 699
Query: 620 PPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQ-----GYRVMYRQ 674
P V +V G + + + +TW D P+ +Q GY V +R
Sbjct: 700 PE---VPPSEVNGGGG------------SRSELVITW--DPVPEELQNGEGFGYVVAFRP 742
Query: 675 TSGLQATSSWQNLDAKVPTERSAVLVN--LKKGVTYEIKVRPYFNEFQGMDSESKTVRTT 732
++W P V N + YE+KV Y N+ +G S TV +
Sbjct: 743 L----GVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSA 798
Query: 733 EEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI--WCLGNETRFHINK 790
EE P+ P V + S +S+ I VSW+ P NG + Y++ W G +
Sbjct: 799 EEEPTVAPSQV---SANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKM 855
Query: 791 TVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVG 823
V S + GL + Y V A SAG G
Sbjct: 856 KVAGNETSARLRGLKSNLAYYTAVRAYNSAGAG 888
Score = 194 bits (493), Expect = 5e-49
Identities = 211/791 (26%), Positives = 330/791 (41%), Gaps = 94/791 (11%)
Query: 8 QLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIV---SKGEPTTLNCKAEGRPTPTIEW 64
QL+L F+ + G L Q P ++ PS+ I S+ + TL+C+A G P+P W
Sbjct: 7 QLILLSFIGC-LGGELLLQG---PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRW 62
Query: 65 YKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNA 124
+G +D D HR L G+L +V D G+Y C A N LG VSR A
Sbjct: 63 QLNG----SDIDMSMEHRYKLNGGNL----VVINPNRNWDTGTYQCFATNSLGTIVSREA 114
Query: 125 SLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYW---KKDKVRIDDKEERI 181
L+ A L + + + V V G+ +L C PP E + W + +D +
Sbjct: 115 KLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFV 174
Query: 182 SIRGGKLMISNTRKSDAGMYTCVGTNMVGERD--SDPAELTV--------FERPTFLRRP 231
S G L IS SD G YTCV T+MV P L + +E ++ P
Sbjct: 175 SQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFP 234
Query: 232 INQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDI-KDDYTLRIKKTMSTDEGT 290
+ V+ C G+P P + W++ D + + K L I D G+
Sbjct: 235 ETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGS 294
Query: 291 YMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKE 350
Y CIAEN GK A LT A P +V +D +A ++ + C G P+P+ W K
Sbjct: 295 YECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKN 354
Query: 351 GSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTD 410
G+ L+ + Q N G LTI+N+ +D+G + C A G + + A+L+V
Sbjct: 355 GAA-LVLEERTQIEN--------GALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVV- 404
Query: 411 VLTDRPPPIILQGPANQTLAVDGTAL--LKCKATGDPLPVISWLKEGFTFPGRDPRATIQ 468
P + P + + V +L L CK P + SW K+G R ++
Sbjct: 405 ----ASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSW-KKGDVSVQEHERISLL 459
Query: 469 EQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE-SGATIS-KNYDLSDLPGPPS 526
G L+I N+ +D GTYTC+A + G+ + + L VTE + T++ N D+S
Sbjct: 460 NDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVIL 519
Query: 527 KPQVTDVTKNSVTLSWQ-PGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGL 585
QV + +W G E S+S + +++ L
Sbjct: 520 PCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGG--SSSGDLMIRNIQ--------L 569
Query: 586 RPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPV 645
+ + Y+ MV+ G+ S +D + PP ++ +V +
Sbjct: 570 KHSGKYVCMVQT----GVDSVSSAADLIVRGSPGPP----ENVKVDE------------- 608
Query: 646 VLTPTTVQVTWTVDRQPQF-IQGYRVMYRQTSGL---QATSSWQNLDAKVPTERSAVLVN 701
+T TT Q++W + + Y + R + T+ + +D K T A +V
Sbjct: 609 -ITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHT---ATVVE 664
Query: 702 LKKGVTYEIKVRPYFNEFQGMDSE--SKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVS 759
L V YE +V N+ G + S+ VRT E P PP V G + + + ++
Sbjct: 665 LNPWVEYEFRV-VASNKIGGGEPSLPSEKVRTEEAVPEVPPSEV---NGGGGSRSELVIT 720
Query: 760 WDPPPPDHQNG 770
WDP P + QNG
Sbjct: 721 WDPVPEELQNG 731
Score = 180 bits (456), Expect = 1e-44
Identities = 219/843 (25%), Positives = 329/843 (39%), Gaps = 99/843 (11%)
Query: 15 LYVRVDGSRLRQEDFPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVE 72
L +R DG ++ P+I V+ P + +KG L C A G P P I W + DG
Sbjct: 214 LVLRSDGV---MGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDG---- 266
Query: 73 TDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP-----DEGSYVCVARNYLGEAVSRNASLE 127
LP S LR G P D GSY C+A N G+ V+R
Sbjct: 267 ------------LPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTY 314
Query: 128 VALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK 187
A + + Q DV +A + EC+ G P+P+ W K+ + EER I G
Sbjct: 315 YA--KPHWVQLIKDVEIAVEDSLYWECRAS-GKPKPSYRWLKNGAALV-LEERTQIENGA 370
Query: 188 LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEE--EAVEFR 245
L ISN +D+GM+ C+ N G S V P F + P+ ++V + V
Sbjct: 371 LTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLD 430
Query: 246 CQVQGDPQPTVRWKKDDADLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEA 304
C+ + P+ WKK D + R + +D L+I D GTY C+AEN+ GK
Sbjct: 431 CKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANG 490
Query: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQP 364
+ L V P + + P + V+ G +V PC+ + +P + + + L +
Sbjct: 491 TTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSH 550
Query: 365 NSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGP 424
+ S +GDL I NIQ +G Y+C T S+ + A L ++ P P P
Sbjct: 551 FEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADL----IVRGSPGP-----P 601
Query: 425 ANQTL--AVDGTALLKCKATGDP-LPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRIS 481
N + D TA L K D PVIS ++ R P ++ Q + +
Sbjct: 602 ENVKVDEITDTTAQLSWKEGKDNHSPVIS-----YSIQARTP-FSVGWQTVTTVPEVIDG 655
Query: 482 DTGTYTCVATSSSGETSWSAVLDVTESGATIS----KNYDLSDLPG-PPSKPQVTDVTKN 536
T T T V + E + V G S K +P PPS+ +++
Sbjct: 656 KTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRS 715
Query: 537 SVTLSWQPGTPGTLPAS---AYIIEAFSQSVSNSWQTVANHVKTTLYTVRG--LRPNTIY 591
+ ++W P P L Y++ V+ QTV T Y R + P + Y
Sbjct: 716 ELVITWDP-VPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPY 774
Query: 592 LFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTT 651
V N +G P S PV T + V QV L+ +
Sbjct: 775 EVKVGVYNNKG---EGPFS-PVTTVFSAEEEPTVAPSQVSANS------------LSSSE 818
Query: 652 VQVTWTV---DRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTY 708
++V+W + GY V Y G + +SS + E SA L LK + Y
Sbjct: 819 IEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGN---ETSARLRGLKSNLAY 875
Query: 709 EIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQ 768
VR Y + G S + V T + PS PP +V V + T + ++W+
Sbjct: 876 YTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNV----VWNATDTKVLLNWEQVKAMEN 931
Query: 769 NGIIQEYKIW----CLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGV 824
+ YK++ N + NKT + + Y +EV A+T G G
Sbjct: 932 ESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPI-------KEDYIIEVKATTDGGDGT 984
Query: 825 KSE 827
SE
Sbjct: 985 SSE 987
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 211 bits (536), Expect = 5e-54
Identities = 234/965 (24%), Positives = 381/965 (39%), Gaps = 127/965 (13%)
Query: 9 LLLCGF---LYVRVDGSRLRQEDFPPRIVEH-PSDVIVSKGEPTTLNCKAEGRPTPTIEW 64
L LC L V +D L PP I + P D I+ E + C+A+G+P P+ W
Sbjct: 21 LFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSW 80
Query: 65 YKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNA 124
++G + DKD + + P + I+ +++ EG Y C ARN G AVS N
Sbjct: 81 TRNGTHFDIDKDPLVTMK---PGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNI 137
Query: 125 SLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR 184
+ + ++ + + +G+ +L C+PP G P P I+W + + + ER+S
Sbjct: 138 VVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQG 197
Query: 185 -GGKLMISNTRKSDAGM-YTCVG----TNMVGER--------------DSDPAELTVFE- 223
G L SN D Y C T + ++ D+ A L+ E
Sbjct: 198 LNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEF 257
Query: 224 ---------RPTFLR---RPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYD 271
PTFL N+ L + C +G P P + W K+D LP+ R
Sbjct: 258 YGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTV 317
Query: 272 IKD-DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRT 330
K+ + TL+I D G Y CIA+N +G + + ++ V+A P ++ P++ +++ G
Sbjct: 318 YKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGED 377
Query: 331 VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI-TNIQRSDAGYY 389
T C GNP+P + W G + P+ P S GD I +N+Q + Y
Sbjct: 378 GTLICRANGNPKPRISWLTNGVPIEIAPDDP-------SRKIDGDTIIFSNVQERSSAVY 430
Query: 390 ICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVI 449
C A G +LA A + V PP I+ + + ALL C G PLP I
Sbjct: 431 QCNASNEYGYLLANAFVNV----LAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTI 486
Query: 450 SWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESG 509
W K + + E GTL+I + TGTYTCVA + G L++ +
Sbjct: 487 EWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPT 546
Query: 510 ATISK-NYDLSDLPGPPS-KPQVTDVTKNSVTLSWQPGTPG-------TLPASAYIIEAF 560
+ + Y + S + +V S+T+ W T+ ++
Sbjct: 547 WIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADV 606
Query: 561 SQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 620
S S ++ VAN TTL +V LS +P P D+
Sbjct: 607 SDDDSGTYTCVAN---TTLDSVSA---------------SAVLSVVAPTPTPAPVYDVPN 648
Query: 621 PAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTV-DRQPQFIQGYRVMYRQTSGLQ 679
P EL D L + +VQ++WT D I + + Y +
Sbjct: 649 P-------PFDLELTDQLDK----------SVQLSWTPGDDNNSPITKFIIEYE--DAMH 689
Query: 680 ATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAP 739
W + T+ +A L L V Y +V + + + SE+ T+ S P
Sbjct: 690 KPGLWHHQTEVSGTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTK--ASEP 746
Query: 740 PQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSV 799
++ T + ++ ++W P NG +YK+ + V A +
Sbjct: 747 DKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKY 806
Query: 800 IIGGLFPGIQYRVEVAASTSAGVGVKSEPQP-IIIGRRNE--VVITENN---NSITEQIT 853
I+ G + Y ++V A G P+P +++G E ++ N N + +
Sbjct: 807 IVSGTPTFVPYLIKVQALNDMGFA----PEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLA 862
Query: 854 DVVKQPAFIAGIGGACWVILMGFSIWLYWR-----RKKRKGLSNYAVTFQRGDGGLMSNG 908
+V P + I G L G+ I+ YW+ ++ R+ + +TFQ G ++G
Sbjct: 863 EVHWDPVPLKSIRGH----LQGYRIY-YWKTQSSSKRNRRHIEKKILTFQ----GSKTHG 913
Query: 909 SRPGL 913
PGL
Sbjct: 914 MLPGL 918
Score = 166 bits (420), Expect = 1e-40
Identities = 203/821 (24%), Positives = 336/821 (40%), Gaps = 108/821 (13%)
Query: 44 KGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP 103
+G +L C AEG PTP I W K+ + ++ ++ L +I+H S+
Sbjct: 284 RGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTL--------QIIHV--SEA 333
Query: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEP 163
D G+Y C+A+N LG A+ S+ V + P ++V++ GE L C+ G+P+P
Sbjct: 334 DSGNYQCIAKNALG-AIHHTISVRVKAA-PYWITAPQNLVLSPGEDGTLICRA-NGNPKP 390
Query: 164 TIYWKKDKVRI----DDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAEL 219
I W + V I DD +I G ++ SN ++ + +Y C +N G ++ A +
Sbjct: 391 RISWLTNGVPIEIAPDDPSRKID--GDTIIFSNVQERSSAVYQCNASNEYGYLLAN-AFV 447
Query: 220 TVFERPTFLRRPIN---QVVLEEEAVEFRCQVQGDPQPTVRWKKD--DADLPRGRYDIKD 274
V P + P N QV+ A+ C G P PT+ W K + L Y + +
Sbjct: 448 NVLAEPPRILTPANTLYQVIANRPAL-LDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHE 506
Query: 275 DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP 334
+ TL I GTY C+A N++G + L ++ P V +P +V +G V+F
Sbjct: 507 NGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFE 566
Query: 335 CETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQ 392
C+ K + V W K+ N+ + R +V L + ++ D+G Y C
Sbjct: 567 CKVKHDHTLSLTVLWLKD--------NRELPSDERFTVD-KDHLVVADVSDDDSGTYTCV 617
Query: 393 ALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWL 452
A T S+ A A V V+ P P + N ++ T L D +SW
Sbjct: 618 ANTTLDSVSASA---VLSVVAPTPTPAPVYDVPNPPFDLELTDQL------DKSVQLSWT 668
Query: 453 KEGFTFPGRD-----PRATIQEQGTLQIKNL---RISDTGTYTCVATSSSGETSWS---- 500
PG D + I+ + + L + +GT T S ++S
Sbjct: 669 ------PGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVM 722
Query: 501 AVLDVTESGATISKNYDLSDLPGPPSKPQVTD---VTKNSVTLSWQP--GTPGTLPASAY 555
AV + +S + + L+ P P + +++ ++W+P G P Y
Sbjct: 723 AVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQY 782
Query: 556 IIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRT 615
+ + + W +V + Y V G YL V+A+N G + P P
Sbjct: 783 KVSWRQKDGDDEWTSVV-VANVSKYIVSGTPTFVPYLIKVQALNDMGFA-PEPA------ 834
Query: 616 QDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQP-----QFIQGYRV 670
+ G D V G+V V V+ T +V W D P +QGYR+
Sbjct: 835 --VVMGHSGEDLPMVAP--GNVRVN-----VVNSTLAEVHW--DPVPLKSIRGHLQGYRI 883
Query: 671 MYRQTSGLQATSSWQNLDAKVPT----ERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSES 726
Y +T + + ++++ K+ T + +L L+ Y + VR + +G S
Sbjct: 884 YYWKTQS-SSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPD 942
Query: 727 KTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRF 786
+ T E PSAP + L + + S+++ WD PP H NGI+ EY + +
Sbjct: 943 RVFNTPEGVPSAP----SSLKIVNPTLDSLTLEWD--PPSHPNGILTEYTLKYQPINSTH 996
Query: 787 HINKTVDAAIRS----VIIGGLFPGIQYRVEVAASTSAGVG 823
+ VD I + + L +Y+ A TSAG G
Sbjct: 997 ELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSG 1037
Score = 120 bits (301), Expect = 9e-27
Identities = 210/904 (23%), Positives = 340/904 (37%), Gaps = 118/904 (13%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P + P ++++S GE TL C+A G P P I W +G +E DDP S ++ G
Sbjct: 361 PYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDP-SRKI---DGDT 416
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVV--VAAGE 148
V R S Y C A N G ++ NA + V L P + + V A
Sbjct: 417 IIFSNVQERSS----AVYQCNASNEYGYLLA-NAFVNV-LAEPPRILTPANTLYQVIANR 470
Query: 149 PAILECQPPRGHPEPTIYWKKD-KVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTN 207
PA+L+C G P PTI W K K ++ + G L I +K G YTCV N
Sbjct: 471 PALLDCAF-FGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARN 529
Query: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDP--QPTVRWKKDDADL 265
+G ++ L + + +++P VV V F C+V+ D TV W KD+ +L
Sbjct: 530 KLGMAKNE-VHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 588
Query: 266 PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP------------ 313
P D L + D GTY C+A + + ASA L+V AP
Sbjct: 589 PSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPN 648
Query: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
P F + DQ+ + P + +P + E + + +P + + VS
Sbjct: 649 PPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMH-----KPGLWHHQTEVS-- 701
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
G T ++ S Y + + V SI E ++ + P AV+G
Sbjct: 702 GTQTTAQLKLSPYVNYSFRVMAV-NSIGKSLPSEASEQYLTKASE-----PDKNPTAVEG 755
Query: 434 TALLKCKATGDPLPVISWLK-EGFTFPGRDPRATI---QEQGTLQIKNLRISDTGTYTCV 489
+ D L VI+W GF G + + Q+ G + ++ +++ Y V
Sbjct: 756 LG-----SEPDNL-VITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYI-V 808
Query: 490 ATSSSGETSWSAVLDVTESG----ATISKNYDLSDLPG-PPSKPQVTDVTKNSVTLSWQP 544
+ + + V + + G + + DLP P +V V + W P
Sbjct: 809 SGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDP 868
Query: 545 GTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRG---------LRPNTIYLFMV 595
++ + +S + H++ + T +G L P + Y V
Sbjct: 869 VPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNV 928
Query: 596 RAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVT 655
R +N +G SP D V P+ + V L + + P P +
Sbjct: 929 RVVNGKGEGPASP--DRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPS--HPNGILTE 984
Query: 656 WTVDRQPQFIQGYRVMYRQTSGLQATSSWQNL-DAKVPTERSA-VLVNLKKGVTYEIKVR 713
+T+ QP + +T L D K+P ++ L NL Y+
Sbjct: 985 YTLKYQP---------------INSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFY 1029
Query: 714 PYFNEFQGMDSESKTVRTTEEAPSAPPQ-----------SVTVLTVGSYNSTSISVSWDP 762
+ G + V T +EA PP ++ LT + T ++SW+
Sbjct: 1030 AQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAE-TYANISWEY 1088
Query: 763 PPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGV 822
P+H N + EY + E R I V+ + + GL PG Y+V V A +G
Sbjct: 1089 EGPEHVNFYV-EYGVAGSKEEWRKEI---VNGSRSFFGLKGLMPGTAYKVRVGAVGDSGF 1144
Query: 823 GVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYW 882
V SE + E ++ + D+ Q FI G+ A ++++ I +
Sbjct: 1145 -VSSED------------VFETGPAMASRQVDIATQGWFI-GLMCAVALLILILLIVCFI 1190
Query: 883 RRKK 886
RR K
Sbjct: 1191 RRNK 1194
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 209 bits (532), Expect = 1e-53
Identities = 213/768 (27%), Positives = 333/768 (43%), Gaps = 82/768 (10%)
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR---------Q 137
+G+L+ ++ K D G+Y CV N + + L D Q
Sbjct: 176 TGNLYIAKV-----EKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQ 230
Query: 138 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSD 197
P V A G LEC G+P PTI W++ + ++ R G L I N ++ D
Sbjct: 231 FPETVPTAKGATVKLECFA-LGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQED 289
Query: 198 AGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVR 257
AG+Y CV N G+ + +LT + +P ++++ + V EE V + C+ G P+PT +
Sbjct: 290 AGLYECVAENSRGKNVAR-GQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYK 348
Query: 258 WKKDDADL-PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP-PQ 315
W K+ L R R I+ TL I +D G Y C+AEN+ G + ++A L+V A P
Sbjct: 349 WLKNGEPLLTRDRIQIEQG-TLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPD 407
Query: 316 F--VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
F + R +V G V C+ K +P+P W+K +++L + N R ++S
Sbjct: 408 FSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDIL------KENERITISED 459
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
G+L I N+ +SDAG Y C A G+ + L V D P ++ P++ + V
Sbjct: 460 GNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD------PTRVMVPPSSMDVTVGE 513
Query: 434 TALLKCKATGDPLP--VISWLKEGFTFP-GRD----PRATIQEQ-GTLQIKNLRISDTGT 485
+ +L C+ T D V +W G RD R Q+ G L I+N+++ G
Sbjct: 514 SIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGK 573
Query: 486 YTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 545
Y C+ +S S +A L V PGPP + ++T + LSW+PG
Sbjct: 574 YVCMVQTSVDRLSAAADLIVRGP-------------PGPPEAVTIDEITDTTAQLSWRPG 620
Query: 546 TPGTLPASAYIIEAFSQSVSNSWQTVAN-----HVKTTLYTVRGLRPNTIYLFMVRAINP 600
P + Y+I+A + S WQ V+ KT TV GL P Y F A N
Sbjct: 621 PDNHSPITMYVIQARTP-FSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANV 679
Query: 601 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR 660
G+ +PS S+ RT++ P V V G + +V+T TV R
Sbjct: 680 IGIGEPSRPSEKRRTEEALPE---VTPANVSGGGGS-----KSELVITWETVPEELQNGR 731
Query: 661 QPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQ 720
++ +R + L +S DA R+ ++ +E+KV + N+ +
Sbjct: 732 GFGYVVAFRPYGKMIWMLTVLAS---ADASRYVFRNE---SVHPFSPFEVKVGVFNNKGE 785
Query: 721 GMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCL 780
G S + V + EE P+ PP S+ S ++T I V W P + G IQ Y++
Sbjct: 786 GPFSPTTVVYSAEEEPTKPPASI---FARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYW 841
Query: 781 GNETRFHINKTVDAA--IRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 826
+E + + + S I L + Y + V A SAG G S
Sbjct: 842 RHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSS 889
Score = 200 bits (508), Expect = 9e-51
Identities = 157/514 (30%), Positives = 225/514 (43%), Gaps = 40/514 (7%)
Query: 9 LLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIV---SKGEPTTLNCKAEGRPTPTIEWY 65
L+L F+ D S L P ++ PS V+ S+ + LNC+ +G P P I W
Sbjct: 8 LVLQSFILCLADDSTLHG----PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWK 63
Query: 66 KDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNAS 125
+G V+T D R + GSL +++ D G+Y C A N G VSR A
Sbjct: 64 LNGTDVDTGMD----FRYSVVEGSL----LINNPNKTQDAGTYQCTATNSFGTIVSREAK 115
Query: 126 LEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV-RIDDKEERISIR 184
L+ A L + + + V V G+ +L C PP E + W ++ D +S
Sbjct: 116 LQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQE 175
Query: 185 GGKLMISNTRKSDAGMYTCVGTNMVGERD--SDPAELTV--------FERPTFLRRPINQ 234
G L I+ KSD G YTCV TN V P L + +E ++ P
Sbjct: 176 TGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETV 235
Query: 235 VVLEEEAVEFRCQVQGDPQPTVRWKKDDAD-LPRGRYDIKDDYTLRIKKTMSTDEGTYMC 293
+ V+ C G+P PT+ W++ D + R K + L I D G Y C
Sbjct: 236 PTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYEC 295
Query: 294 IAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQ 353
+AEN GK A LT A P ++ + D VA V + C+ G P+P W K G
Sbjct: 296 VAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNG-- 353
Query: 354 NLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413
+P R + G L IT + SDAG Y C A G I + A+L V V
Sbjct: 354 ------EPLLTRDRIQIE-QGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGP 406
Query: 414 DRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTL 473
D ++ + + V G +++CK P PV +W K+G + R TI E G L
Sbjct: 407 DFSRTLLKR---VTLVKVGGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGNL 462
Query: 474 QIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 507
+I N+ SD G+YTC+AT+ G S + L V +
Sbjct: 463 RIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD 496
Score = 166 bits (421), Expect = 1e-40
Identities = 214/833 (25%), Positives = 326/833 (39%), Gaps = 102/833 (12%)
Query: 28 DFPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRML- 84
++ P+I V+ P V +KG L C A G P PTI W + DG+ + +S+ +L
Sbjct: 222 EYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILE 281
Query: 85 LPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV 144
+P+ + D G Y CVA N G+ V+R A + ++ Q D+ V
Sbjct: 282 IPNFQ------------QEDAGLYECVAENSRGKNVARGQLTFYA--QPNWIQKINDIHV 327
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 204
A E EC+ G P+PT W K+ + ++ RI I G L I+ SDAGMY C+
Sbjct: 328 AMEENVFWECKA-NGRPKPTYKWLKNGEPLLTRD-RIQIEQGTLNITIVNLSDAGMYQCL 385
Query: 205 GTNMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVE--FRCQVQGDPQPTVRWKKD 261
N G S+ AEL+V P F R + +V L + E C+ + P+P WKK
Sbjct: 386 AENKHGVIFSN-AELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKG 444
Query: 262 DADLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
L R I +D LRI +D G+Y CIA N G ++ L V+ P + +V P
Sbjct: 445 RDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPP 504
Query: 321 RDQIVAQGRTVTFPCE-TKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 379
V G ++ PC+ T + VF + F GDL I
Sbjct: 505 SSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIR 564
Query: 380 NIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL---AVDGTAL 436
NIQ AG Y+C T + A A L V R PP GP D TA
Sbjct: 565 NIQLKHAGKYVCMVQTSVDRLSAAADLIV------RGPP----GPPEAVTIDEITDTTAQ 614
Query: 437 LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGE 496
L + D I+ + R P ++ Q + L T T T V + E
Sbjct: 615 LSWRPGPDNHSPITM----YVIQARTP-FSVGWQAVSTVPELIDGKTFTATVVGLNPWVE 669
Query: 497 ----TSWSAVLDVTESGATISKNYDLSDLPG-PPSKPQVTDVTKNSVTLSWQ--PGTPGT 549
T + V+ + E K LP P+ +K+ + ++W+ P
Sbjct: 670 YEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQN 729
Query: 550 LPASAYIIEAFSQSVSNSWQ-TVANHVKTTLYTVR--GLRPNTIYLFMVRAINPQGLSDP 606
Y++ AF W TV + Y R + P + + V N +G
Sbjct: 730 GRGFGYVV-AFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPF 788
Query: 607 SPMSDPVRTQD--ISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT--VDRQP 662
SP + ++ PPA + R L+ T ++V W +++
Sbjct: 789 SPTTVVYSAEEEPTKPPA-------------SIFAR-----SLSATDIEVFWASPLEKNR 830
Query: 663 QFIQGYRVMYRQTSGLQATSSWQNLDAK--------VPTERSAVLVNLKKGVTYEIKVRP 714
IQGY V Y W++ D + V + S + NLK V Y + V+
Sbjct: 831 GRIQGYEVKY-----------WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKA 879
Query: 715 YFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQE 774
Y + G S + V T + PS PP ++ + + + + I ++WD ++
Sbjct: 880 YNSAGTGPSSATVNVTTRKPPPSQPPGNI----IWNSSDSKIILNWDQVKALDNESEVKG 935
Query: 775 YKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 827
YK+ L R ++ SV + F Y +E+ + G G SE
Sbjct: 936 YKV--LYRWNRQSSTSVIETNKTSVELSLPFDE-DYIIEIKPFSDGGDGSSSE 985
Score = 42.0 bits (97), Expect = 0.004
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 9/111 (8%)
Query: 736 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQN---GIIQEYKIWCLGNETRFHINKTV 792
P PP++VT+ + T+ +SW P P +H +IQ + +G + + + +
Sbjct: 596 PPGPPEAVTIDEI---TDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELI 652
Query: 793 DAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITE 843
D + + GL P ++Y A+ G+G S P RR E + E
Sbjct: 653 DGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSE---KRRTEEALPE 700
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 209 bits (531), Expect = 2e-53
Identities = 203/725 (28%), Positives = 302/725 (41%), Gaps = 91/725 (12%)
Query: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRI----DDKEERISIRGGKLMI 190
F P+D V G +L+C P I WKKD + + D++++++S G L+I
Sbjct: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
Query: 191 SNT-----RKSDAGMYTCVGT-NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEF 244
N K D G+Y C + G S A++ V FL + + + V
Sbjct: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
Query: 245 RCQVQGDPQPTVRWKKDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 300
+C+V G+P PT+ W+K+ DL R + L+I + D G Y C A N
Sbjct: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
Query: 301 KMEAS-ATLTVRAPP------QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQ 353
+ A + + + P F+ RP + + +G+ C G P P+ W + G +
Sbjct: 220 SRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEE 278
Query: 354 NLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413
+ Q + + S+ +L I+N+ D+G Y C +I A A+L V
Sbjct: 279 VI------QLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL---- 328
Query: 414 DRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTL 473
PP L P+N +C +G P+P ++W+K G D I L
Sbjct: 329 --VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSNL 385
Query: 474 QIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDV 533
+I + SD G Y CVA + +G SA L V + S S LP P V
Sbjct: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSS-----SVLPSAPRDVVPVLV 440
Query: 534 TKNSVTLSWQPGTPGTLPASAY-IIEAFSQSVSNSWQTVANHVKTTL-----YTVRGLRP 587
+ V LSW+P PA A I+ F+ S + TT TV L+P
Sbjct: 441 SSRFVRLSWRP------PAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKP 494
Query: 588 NTIYLFMVRAINPQGLSDPSPMSDPVR--TQDISPPAQGVDHRQVQKELGDVLVRLHNPV 645
+Y F V A N G P S P++ TQ V++ Q V
Sbjct: 495 EAMYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQA--------------V 537
Query: 646 VLTPTTVQVTWTVDRQPQF----IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVN 701
+PT++ +TW P + +QGYR+ + S T QN++ S L
Sbjct: 538 STSPTSILITW---EPPAYANGPVQGYRLFCTEVS----TGKEQNIEVD---GLSYKLEG 587
Query: 702 LKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWD 761
LKK Y ++ Y G+ ++ TV T + PSAPPQ+V++ V NS SI VSW
Sbjct: 588 LKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVV---NSRSIKVSWL 644
Query: 762 PPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAG 821
PPP QNG I YKI R + +T++ + GL G QY +V+A T G
Sbjct: 645 PPPSGTQNGFITGYKIRHRKTTRRGEM-ETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNG 703
Query: 822 VGVKS 826
G S
Sbjct: 704 TGPPS 708
Score = 208 bits (529), Expect = 3e-53
Identities = 213/822 (25%), Positives = 319/822 (38%), Gaps = 85/822 (10%)
Query: 32 RIVEHPSDVIVSKGEPTTLNCKAEG-RPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
R + PSD + +G L+C AE R P I+W KDG + D+ + L +GSL
Sbjct: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
Query: 91 FFLRIVHGRRSKPDEGSYVCVAR-NYLGEAVSRNASLEVA-LLRDDFRQNPTDVVVAAGE 148
I+H R KPDEG Y C A G +SR A + VA LR F V G+
Sbjct: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
Query: 149 PAILECQPPRGHPEPTIYWKK---DKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVG 205
+L+C+ G P PTI+W+K D I + + G L IS + D G+Y C
Sbjct: 156 TVLLKCEVI-GEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
Query: 206 TNMVGERDSDPAELTVFERPT------FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
N R + AE+ + P FL+RP N V +E + C V G P P+ W
Sbjct: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
Query: 260 KDDA--DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFV 317
+ + L +Y + L I D G Y C+ + + ASA LTV PP F+
Sbjct: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
Query: 318 VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377
P + + + F C G P P V W K G + P+ + +L
Sbjct: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI--------PSDYFQIVGGSNLR 386
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEV-------TDVLTDRPPPIILQGPANQTLA 430
I + +SD G+Y C A AG+ AQL V + VL P ++ +++ +
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVR 446
Query: 431 VDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQ--IKNLRISDTGTYTC 488
+ + K V + +EG R+ + G+LQ + NL+ T+
Sbjct: 447 LSWRPPAEAKGNIQTFTVF-FSREG---DNRERALNTTQPGSLQLTVGNLKPEAMYTFRV 502
Query: 489 VATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPG 548
VA + G S + V +PGP Q + S+ ++W+P
Sbjct: 503 VAYNEWGPGESSQPIKVATQPEL--------QVPGPVENLQAVSTSPTSILITWEPPAYA 554
Query: 549 TLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSP 608
P Y F VS + V Y + GL+ T Y A N G +
Sbjct: 555 NGPVQGY--RLFCTEVSTGKEQNI-EVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTD 611
Query: 609 MSDPVRTQDI-SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTW---TVDRQPQF 664
V D+ S P Q V V+ +++V+W Q F
Sbjct: 612 DITVVTLSDVPSAPPQNVSLE-----------------VVNSRSIKVSWLPPPSGTQNGF 654
Query: 665 IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDS 724
I GY++ +R+ T+ ++ P + L+KG Y +V G S
Sbjct: 655 ITGYKIRHRK------TTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPS 708
Query: 725 ESKTVRTTEE--APSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGN 782
T T E S P + L V + I +SW PP + N +++ Y I G
Sbjct: 709 NWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPL--NPNIVVRGYIIG-YGV 764
Query: 783 ETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGV 824
+ + VD+ R I L Y + + A +AG GV
Sbjct: 765 GSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
Score = 191 bits (484), Expect = 5e-48
Identities = 229/842 (27%), Positives = 332/842 (39%), Gaps = 117/842 (13%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
P R + V G+ L C+ G P PTI W K+ + + D R ++LPSG+
Sbjct: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-------FRQNPTDV 142
L R+ G D G Y C ARN A EV +L D F Q P++V
Sbjct: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
Query: 143 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGG-KLMISNTRKSDAGMY 201
V G+ A+LEC G+P P+ W + + I + ++ S+ GG L+ISN D+GMY
Sbjct: 250 VAIEGKDAVLEC-CVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
Query: 202 TCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 261
TCV T E S AELTV P FL P N E +EF C V G P PTV W K+
Sbjct: 309 TCVVT-YKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
Query: 262 -DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP--PQFVV 318
D +P + I LRI + +DEG Y C+AEN G + SA L V P P V
Sbjct: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
Query: 319 ---RPRD--QIVAQGRTVTF----PCETKGNPQP-AVFWQKEGSQNLLFPNQPQQPNSRC 368
PRD ++ R V P E KGN Q VF+ +EG N QP S
Sbjct: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALN-TTQPGSL- 485
Query: 369 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT 428
LT+ N++ + A G + ++V P + + GP
Sbjct: 486 ------QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVA-----TQPELQVPGPVENL 534
Query: 429 LAVDGTALLKCKATGDPLPVISWLKEGF-TFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487
AV +T +I+W + P + R E T + +N+ + D +Y
Sbjct: 535 QAV---------STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEV-DGLSYK 584
Query: 488 CVATSSSGETSWSAVLDVTESGATISKN----YDLSDLP-GPPSKPQVTDVTKNSVTLSW 542
E S L G +S + LSD+P PP + V S+ +SW
Sbjct: 585 LEGLKKFTEYS-LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSW 643
Query: 543 QPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINP 600
P GT + Y I + +T+ + L+T GL + Y F V A+
Sbjct: 644 LPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFT--GLEKGSQYSFQVSAMTV 701
Query: 601 QGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR 660
G PS P +D QV + + VR ++ ++WT
Sbjct: 702 NGTGPPS------NWYTAETPENDLDESQVPDQPSSLHVRPQTNCII------MSWTPPL 749
Query: 661 QPQF-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEF 719
P ++GY + Y S T +D+K +R + L+ Y I ++ + N
Sbjct: 750 NPNIVVRGYIIGYGVGSPYAET---VRVDSK---QRYYSIERLESSSHYVISLKAFNNAG 803
Query: 720 QGMD-SESKTVRTTEE----------------------APSAPPQSVTVLTVGSYNSTSI 756
+G+ ES T R+ + P PP V + + ++
Sbjct: 804 EGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVAL---THDAV 860
Query: 757 SVSW-DPPPPDHQNGIIQEYKIWCLGNETRFHIN---KTVDAAIRSVIIGGLFPGIQYRV 812
VSW D P +Q E +++ + T F + K+ D S GL P Y
Sbjct: 861 RVSWADNSVPKNQK--TSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEF 918
Query: 813 EV 814
V
Sbjct: 919 SV 920
Score = 71.6 bits (174), Expect = 5e-12
Identities = 85/341 (24%), Positives = 137/341 (40%), Gaps = 42/341 (12%)
Query: 511 TISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSW-Q 569
T + D S +P PS V T N + +SW P + YII V + + +
Sbjct: 715 TPENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAE 770
Query: 570 TVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQ 629
TV K Y++ L ++ Y+ ++A N G + P+ + T+ I+ P VD+
Sbjct: 771 TVRVDSKQRYYSIERLESSSHYVISLKAFNNAG--EGVPLYESATTRSITDPTDPVDYYP 828
Query: 630 VQKELGDVLVRLHNP---------VVLTPTTVQVTWTVDRQPQF-----IQGYRVMYRQT 675
+ + + L P V LT V+V+W + P+ ++ Y V +R
Sbjct: 829 LLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWR-- 886
Query: 676 SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 735
+ A++ +++ D T S LK YE V N S + T E A
Sbjct: 887 TSFSASAKYKSEDT---TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAA 943
Query: 736 PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 795
P++ P+ +TV+T ++ VSW PP NG I Y ++ ++ N +D
Sbjct: 944 PTSAPKDLTVIT-REGKPRAVIVSWQPPL--EANGKITAYILFYTLDK-----NIPIDDW 995
Query: 796 IRSVIIG--------GLFPGIQYRVEVAASTSAGVGVKSEP 828
I I G L Y + A S GVG S+P
Sbjct: 996 IMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 206 bits (524), Expect = 1e-52
Identities = 229/857 (26%), Positives = 351/857 (40%), Gaps = 105/857 (12%)
Query: 13 GFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 72
G L V + G +E PPR ++ P D I G + C+A G P P + W K G++V
Sbjct: 17 GLLVVLLVGGCAAEE--PPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN 74
Query: 73 TDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR 132
+ R + + LRI R+ DE Y CVA+N +GE ++ +A L V LR
Sbjct: 75 SQ----RFETIEFDESAGAVLRI-QPLRTPRDENVYECVAQNSVGE-ITVHAKLTV--LR 126
Query: 133 DD--------FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEE--RI- 181
+D P VV A + C G+P+P I W KD + +D RI
Sbjct: 127 EDQLPSGFPNIDMGPQLKVVERTRTATMLC-AASGNPDPEITWFKDFLPVDPSASNGRIK 185
Query: 182 SIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFER---PTFLRRPINQVVLE 238
+R G L I ++ ++D G Y CV TN G R S PA L V R P F P++ ++
Sbjct: 186 QLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMP 245
Query: 239 EEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLR---IKKTMSTDEGTYMCIA 295
V C G P P V+W + DL +DD + ++ T D Y C+A
Sbjct: 246 GGNVNITCVAVGSPMPYVKWMQGAEDLTP-----EDDMPVGRNVLELTDVKDSANYTCVA 300
Query: 296 ENRVGKMEASATLTVRAPPQFVVRPR-DQIVAQGRTVTFPCETKGNPQPAVFW---QKEG 351
+ +G +EA A +TV++ P+ P + A T+T+ GNP P ++ K
Sbjct: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKSK 357
Query: 352 SQNLLFPNQPQQPNSRCSV---SPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEV 408
SQ+ + + +R S+ SP + I ++ SI E
Sbjct: 358 SQDGPYQIKEDITTTRYSIGGLSPNSEYEIW--------------VSAVNSIGQGPPSES 403
Query: 409 TDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP----- 463
T P + T +++ + +P +I + +T P
Sbjct: 404 VVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ 463
Query: 464 RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV-TESGATISKNYDLSDLP 522
+ + + + +L +T T +A +S G+ S + V T+ G +P
Sbjct: 464 KHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG-----------VP 512
Query: 523 GPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYII--EAFSQSVSNSWQTVANHVKTTLY 580
G P + ++ S+TLSW P P II E + + + TT Y
Sbjct: 513 GQPMNLRAEARSETSITLSWSP------PRQESIIKYELLFREGDHGREVGRTFDPTTSY 566
Query: 581 TVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVR 640
V L+PNT Y F + A +PQGL +P+ RT P A D + V +LV
Sbjct: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQ-RTLQSKPSAPPQDVKCVSVRSTAILVS 625
Query: 641 LHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLV 700
P T V GY V YR + ++ PT +L
Sbjct: 626 WRPPPPETHNGALV------------GYSVRYRPLGSEDPEP--KEVNGIPPTTTQILLE 671
Query: 701 NLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSW 760
L+K Y I + G +S VRT E+ PSAPP+ V + N+T+I V W
Sbjct: 672 ALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKV---EAEALNATAIRVLW 728
Query: 761 DPPPPDHQNGIIQEYKIWCL---GNETRF--HINKTVDAAIRSVIIGGLFPGIQYRVEVA 815
P P Q+G I+ Y++ + G E R I + A + ++I L P Y + VA
Sbjct: 729 RSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVA 788
Query: 816 ASTSAGVGVKSEPQPII 832
A T G G +S+P+ ++
Sbjct: 789 AYTMKGDGARSKPKVVV 805
Score = 97.8 bits (242), Expect = 6e-20
Identities = 181/787 (22%), Positives = 285/787 (36%), Gaps = 125/787 (15%)
Query: 24 LRQEDFP---PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
LR++ P P I P +V + T+ C A G P P I W+KD V+ + R
Sbjct: 125 LREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRI 184
Query: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR--DDFRQN 138
+ L SG+L + D+G Y CVA N G S A+L V + R F
Sbjct: 185 KQ--LRSGALQI-----ESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSIL 237
Query: 139 PTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDA 198
P + G + C G P P + W + + +++ + G+ ++ T D+
Sbjct: 238 PMSHEIMPGGNVNITCVAV-GSPMPYVKWMQGAEDLTPEDD---MPVGRNVLELTDVKDS 293
Query: 199 GMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ-GDPQPT-- 255
YTCV + +G ++ A++TV P + P +V E A G+P P
Sbjct: 294 ANYTCVAMSSLGVIEA-VAQITVKSLP---KAPGTPMVTENTATSITITWDSGNPDPVSY 349
Query: 256 --VRWKKDDADLPRGRYDIKDDYTLR---IKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
+ +K D G Y IK+D T I E A N +G+ S ++
Sbjct: 350 YVIEYKSKSQD---GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVT 406
Query: 311 RAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLL-------FPNQPQQ 363
R Q + A+ + T V W++ N L + +P+
Sbjct: 407 RTGEQAPASAPRNVQARMLSAT---------TMIVQWEEPVEPNGLIRGYRVYYTMEPEH 457
Query: 364 PNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDV----LTDRPPPI 419
P G+ N+ S LT GS+L V + + D P
Sbjct: 458 P--------VGNWQKHNVDDS--------LLTTVGSLLEDETYTVRVLAFTSVGDGPLSD 501
Query: 420 ILQGPANQTLAVDGTAL-LKCKATGDPLPVISW--------LKEGFTFP----GRDPRAT 466
+Q Q V G + L+ +A + +SW +K F GR+ T
Sbjct: 502 PIQVKTQQ--GVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRT 559
Query: 467 IQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPG-PP 525
+ +++L+ + + A S G +++ V+ + L P PP
Sbjct: 560 FDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV----------RQRTLQSKPSAPP 609
Query: 526 SKPQVTDVTKNSVTLSWQPGTPGTLPAS--AYIIEAFSQSVSNSWQTVANHVK--TTLYT 581
+ V ++ +SW+P P T + Y + + N + TT
Sbjct: 610 QDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQIL 669
Query: 582 VRGLRPNTIYLFMVRAINPQGLSDPSPMSDPV--RTQDISPPAQGVDHRQVQKELGDVLV 639
+ L T Y A G P P S PV RT + P A R+V+ E
Sbjct: 670 LEALEKWTQYRITTVAHTEVG---PGPESSPVVVRTDEDVPSAPP---RKVEAE------ 717
Query: 640 RLHNPVVLTPTTVQVTW---TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERS 696
L T ++V W RQ I+GY+V Y + G +A + D + +
Sbjct: 718 ------ALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQE 771
Query: 697 AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 756
V+ NL+ Y I V Y + G S+ K V T P SV G S+
Sbjct: 772 MVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEG-----SL 826
Query: 757 SVSWDPP 763
W+PP
Sbjct: 827 LARWEPP 833
Score = 43.9 bits (102), Expect = 0.001
Identities = 68/324 (20%), Positives = 119/324 (36%), Gaps = 41/324 (12%)
Query: 520 DLPG-PPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTT 578
D+P PP K + + ++ + W+ PG + + + +K
Sbjct: 705 DVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDV 764
Query: 579 LYT------VRGLRPNTIYLFMVRAINPQGLSDPS-PMSDPVRTQDISPPAQGVDHRQVQ 631
+ + L+P T Y V A +G S P + + P V Q
Sbjct: 765 MLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ----Q 820
Query: 632 KELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMY-RQTSGLQATSSWQNLDAK 690
G +L R P T + Q + GYR+ + R+ S AT +
Sbjct: 821 TPEGSLLARWEPPA----------GTAEDQ---VLGYRLQFGREDSTPLATLEFP----- 862
Query: 691 VPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGS 750
P+E + KG TY ++ G ++ ++ + E+ P PQ + G+
Sbjct: 863 -PSEDRYTASGVHKGATYVFRLAARSRGGLGEEA-AEVLSIPEDTPRGHPQILEA--AGN 918
Query: 751 YNSTSISVSWDPPPPDHQNGIIQEYKI-----WCLGNETRFHINKTVD-AAIRSVIIGGL 804
++ ++ + W PP P +NG I +Y + LG + + A ++ + GL
Sbjct: 919 ASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGL 978
Query: 805 FPGIQYRVEVAASTSAGVGVKSEP 828
P Y ++V A T G G S P
Sbjct: 979 KPDTAYDLQVRAHTRRGPGPFSPP 1002
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 206 bits (523), Expect = 2e-52
Identities = 136/412 (33%), Positives = 201/412 (48%), Gaps = 23/412 (5%)
Query: 113 RNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV 172
R G +V+ E+ R P D V +G C+ G+P+P I W ++
Sbjct: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
Query: 173 RIDDK-EERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVF---ERPTF 227
+ K + R+++ G LMI NT+++D G+Y C+ N+ GE + L F RPTF
Sbjct: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
Query: 228 LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD-ADLPRG-RYDIKDDYTLRIKKTMS 285
+ +P N VL E+V C G P P + W + D LP R +I L I+ +
Sbjct: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
Query: 286 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 345
D G Y C A N + + A+A + V+A PQF V P+D++V +G+TV F CE KGNP P +
Sbjct: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
Query: 346 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQ 405
W K GSQ + R V +G L I+ + D G Y CQA+ + GS A
Sbjct: 465 AWTKGGSQ--------LSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
Query: 406 LEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRA 465
L V +T P+ P++ T+ V L C + G+P P I+W K+G +
Sbjct: 517 LTVQPRVT----PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT-ESGKF 571
Query: 466 TIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYD 517
I +G L I ++ +D G Y CVA ++ G S S VL V + +S+N D
Sbjct: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV--NVPDVSRNGD 621
Score = 184 bits (468), Expect = 4e-46
Identities = 124/384 (32%), Positives = 175/384 (45%), Gaps = 24/384 (6%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
PRI P D V+ G C+AEG P P I W ++ + D S LL G+L
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV--ALLRDDFRQNPTDVVVAAGE 148
+ D+G Y C+A+N GE ++ +L + R F P + V GE
Sbjct: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
Query: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTN 207
LEC GHP P I W + + R++I G L I N + D+G Y C TN
Sbjct: 358 SVTLECS-ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
Query: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP- 266
+ + A + V P F P ++VV+E + V+F+C+ +G+P P + W K + L
Sbjct: 417 NIDSVHA-TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
Query: 267 RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVRPRDQI 324
R+ + TLRI D+G Y C A N +G + A LTV R P F P D
Sbjct: 476 DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS 384
V G V PC ++G P+PA+ W K+G Q + + +SP G LTI ++ +
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVGPA 587
Query: 385 DAGYYICQALTVAGSILAKAQLEV 408
DAG Y C A GS L V
Sbjct: 588 DAGRYECVARNTIGSASVSMVLSV 611
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 205 bits (522), Expect = 2e-52
Identities = 179/619 (28%), Positives = 274/619 (44%), Gaps = 73/619 (11%)
Query: 223 ERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYD-IKDDYT---- 277
E P F++ P +Q+ + F CQ GDP+P V W K + R++ I+ D +
Sbjct: 31 EPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAV 90
Query: 278 LRIKKTMST-DEGTYMCIAENRVGKMEASATLTVRAP-------PQFVVRPRDQIVAQGR 329
LRI+ + DE Y C+A+N VG++ A LTV P + P+ ++V + R
Sbjct: 91 LRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTR 150
Query: 330 TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 389
T T C GNP P + W K+ P P N R +G L I + + +D G Y
Sbjct: 151 TATMLCAASGNPDPEITWFKD-----FLPVDPSASNGRIKQLRSGALQIESSEETDQGKY 205
Query: 390 ICQALTVAG-SILAKAQLEVTDVL-TDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP 447
C A AG + A L V ++ R P P + + G + C A G P+P
Sbjct: 206 ECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMP 265
Query: 448 VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 507
+ W++ D G ++ + D+ YTCVA SS G V E
Sbjct: 266 YVKWMQGAEDLTPEDDMPV----GRNVLELTDVKDSANYTCVAMSSLG---------VIE 312
Query: 508 SGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNS 567
+ A I+ + LP P P VT+ T S+T++W G P P S Y+IE S+S
Sbjct: 313 AVAQIT----VKSLPKAPGTPMVTENTATSITITWDSGNPD--PVSYYVIEYKSKSQDGP 366
Query: 568 WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDH 627
+Q + + TT Y++ GL PN+ Y V A+N G PS S RT + +P +
Sbjct: 367 YQ-IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSE-SVVTRTGEQAPASA---P 421
Query: 628 RQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQ-FIQGYRVMYRQTSGLQATSSWQ- 685
R VQ + L+ TT+ V W +P I+GYRV Y +WQ
Sbjct: 422 RNVQARM------------LSATTMIVQWEEPVEPNGLIRGYRVYYTMEPE-HPVGNWQK 468
Query: 686 -NLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVT 744
N+D + T ++L + TY ++V + + G S+ V+T + P P
Sbjct: 469 HNVDDSLLTTVGSLL----EDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMN--- 521
Query: 745 VLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGL 804
L + + TSI++SW PP Q II+ ++ G+ R + +T D S ++ L
Sbjct: 522 -LRAEARSETSITLSWSPP---RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDL 575
Query: 805 FPGIQYRVEVAASTSAGVG 823
P +Y +AA + G+G
Sbjct: 576 KPNTEYAFRLAARSPQGLG 594
Score = 152 bits (385), Expect = 2e-36
Identities = 170/644 (26%), Positives = 263/644 (40%), Gaps = 86/644 (13%)
Query: 13 GFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 72
G L V + G +E PPR ++ P D I G + C+A G P P + W K G++V
Sbjct: 17 GLLVVLLVGGCAAEE--PPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN 74
Query: 73 TDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR 132
+ R + + LRI R+ DE Y CVA+N +GE ++ +A L V LR
Sbjct: 75 SQ----RFETIEFDESAGAVLRI-QPLRTPRDENVYECVAQNSVGE-ITVHAKLTV--LR 126
Query: 133 DD--------FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEE--RI- 181
+D P VV A + C G+P+P I W KD + +D RI
Sbjct: 127 EDQLPSGFPNIDMGPQLKVVERTRTATMLC-AASGNPDPEITWFKDFLPVDPSASNGRIK 185
Query: 182 SIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFE-------RPTFLRRPINQ 234
+R G L I ++ ++D G Y CV TN G R S PA L V E P F P++
Sbjct: 186 QLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSH 245
Query: 235 VVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLR---IKKTMSTDEGTY 291
++ V C G P P V+W + DL +DD + ++ T D Y
Sbjct: 246 EIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTP-----EDDMPVGRNVLELTDVKDSANY 300
Query: 292 MCIAENRVGKMEASATLTVRAPPQFVVRPR-DQIVAQGRTVTFPCETKGNPQPAVFW--- 347
C+A + +G +EA A +TV++ P+ P + A T+T+ GNP P ++
Sbjct: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIE 357
Query: 348 QKEGSQNLLFPNQPQQPNSRCSV---SPTGDLTITNIQRSDAGYYICQALTVAGSILAKA 404
K SQ+ + + +R S+ SP + I ++ SI
Sbjct: 358 YKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW--------------VSAVNSIGQGP 403
Query: 405 QLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP- 463
E T P + T +++ + +P +I + +T P
Sbjct: 404 PSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPV 463
Query: 464 ----RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV-TESGATISKNYDL 518
+ + + + +L +T T +A +S G+ S + V T+ G
Sbjct: 464 GNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG--------- 514
Query: 519 SDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYII--EAFSQSVSNSWQTVANHVK 576
+PG P + ++ S+TLSW P P II E + + +
Sbjct: 515 --VPGQPMNLRAEARSETSITLSWSP------PRQESIIKYELLFREGDHGREVGRTFDP 566
Query: 577 TTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 620
TT Y V L+PNT Y F + A +PQGL +P+ Q ISP
Sbjct: 567 TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 610
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 205 bits (521), Expect = 3e-52
Identities = 154/473 (32%), Positives = 213/473 (45%), Gaps = 38/473 (8%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P I P V VS + L C+A+G P P + W KD RV D PR +LP GSL
Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD--RVPLDPRSPRFE--ILPEGSL 2537
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-FRQNPTDVVVAAGEP 149
++ D G Y+C+A N G S ++ +L +P+++ + A P
Sbjct: 2538 RIQPVL-----AQDAGHYLCLASNSAG---SDRQGRDLRVLEPPAIAPSPSNLTLTAHTP 2589
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR---GGKLMISNTRKSDAGMYTCVGT 206
A+L C+ G P+P + W KD ++D + ++ + R L+++ D+ + CV +
Sbjct: 2590 ALLPCEAS-GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVS 2648
Query: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL- 265
N VGE ++TV PT + V V C G P PTV W K A L
Sbjct: 2649 NEVGEAHR-LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 2707
Query: 266 PRGR-YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
RG Y + L I + + G Y C A N G LTV+A P VV+P +
Sbjct: 2708 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSV 2765
Query: 325 V--AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQ 382
V V PCE G P+P + WQKEG V P G L I +
Sbjct: 2766 VRAVAEEEVLLPCEASGIPRPTITWQKEGLN--------VATGVSTQVLPGGQLRIAHAS 2817
Query: 383 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKAT 442
DAG Y+C A AGS + K +L V + PP+I G + + A L CKA
Sbjct: 2818 PEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPCKAR 2871
Query: 443 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
G P P I+W K+G G + + TIQ G L +KNL D GTYTC A ++ G
Sbjct: 2872 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 2924
Score = 202 bits (513), Expect = 2e-51
Identities = 147/477 (30%), Positives = 214/477 (44%), Gaps = 31/477 (6%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P + PS V E L C+A G P PTI W K+G V T +LP G L
Sbjct: 2757 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 2811
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 150
RI H S D G+Y+C+A+N G A+ + V + D+ G A
Sbjct: 2812 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 2864
Query: 151 ILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTNMV 209
L C+ RG PEP I W KD + E + +I+ G+L++ N DAG YTC N V
Sbjct: 2865 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2923
Query: 210 GERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 269
G R LT+ P F P ++ + + + RC +G P P + W +D + G
Sbjct: 2924 G-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2982
Query: 270 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQ-G 328
+ TL+ D GTY+C AENRVG+ +A + + V+ P +V G
Sbjct: 2983 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 3042
Query: 329 RTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 388
++ C +G+P P + W K+G P + + G LTI +R DAG
Sbjct: 3043 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIHRTERDDAGR 3094
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
Y C A G +AK + +L + P+ P + T+ L+C+ATG+P P
Sbjct: 3095 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 3148
Query: 449 ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
I WL+ G T+ + G+L ++N+ D GTY CVA + G + A L V
Sbjct: 3149 IEWLQAGQPLRASRRLRTLPD-GSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3204
Score = 182 bits (461), Expect = 3e-45
Identities = 134/486 (27%), Positives = 203/486 (41%), Gaps = 38/486 (7%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I PS++ ++ P L C+A G P P + W+KDG++++ + LLPS +
Sbjct: 2572 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNA 2629
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL-LRDDFRQNPTDVVVAAGE 148
L D + CV N +GEA + +V + + + TD V
Sbjct: 2630 LLLTA-----PGPQDSAQFECVVSNEVGEA---HRLYQVTVHVPPTIADDQTDFTVTMMA 2681
Query: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTN 207
P +L C G P PT+ W K ++ + + G L I AG YTC N
Sbjct: 2682 PVVLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN 2740
Query: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR 267
G LTV P P + EE V C+ G P+PT+ W+K+ ++
Sbjct: 2741 SAGVAHKH-VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT 2799
Query: 268 G-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA 326
G + LRI D G Y+CIA+N G L V+ PP D
Sbjct: 2800 GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT 2859
Query: 327 QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQ-PNSRCSVSPTGDLTITNIQRSD 385
+G PC+ +G+P+P + W K+G QP + ++ P+G+L + N++ D
Sbjct: 2860 EGSHAFLPCKARGSPEPNITWDKDG--------QPVSGAEGKFTIQPSGELLVKNLEGQD 2911
Query: 386 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 445
AG Y C A G + L + + P+ P +++L + L+C A G P
Sbjct: 2912 AGTYTCTAENAVGRARRRVHLTILVL------PVFTTLPGDRSLRLGDRLWLRCAARGSP 2965
Query: 446 LPVISWLKEGFTFPGRDPRATIQEQ---GTLQIKNLRISDTGTYTCVATSSSGETSWSAV 502
P I W T R + EQ TLQ + D+GTY C A + G T +
Sbjct: 2966 TPRIGW-----TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF 3020
Query: 503 LDVTES 508
+ V E+
Sbjct: 3021 VHVKEA 3026
Score = 179 bits (455), Expect = 1e-44
Identities = 150/505 (29%), Positives = 223/505 (44%), Gaps = 46/505 (9%)
Query: 37 PSD-VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95
P D V+V G+ L+C+ + P PT+ WYKDG+ + L G R+
Sbjct: 1847 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQ----RL 1897
Query: 96 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQ 155
D+G Y C N GEAV R +L V + V AG P +L C
Sbjct: 1898 EIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1956
Query: 156 PPRGHPEPTIYWKKDKVRIDDKE-ERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
G P PT+ W KD++ ++ + RGG+L +S + + AG YTCV N E
Sbjct: 1957 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 2015
Query: 215 DPAELTVFERPTFLRRPI--NQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL-----PR 267
D + V P + VLE + V C+ G P P V W KD + L P
Sbjct: 2016 D-FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPH 2074
Query: 268 GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP---QFVVRPRDQI 324
R+ + D +L +K ++D G Y C+A N G+ T+ V PP Q +
Sbjct: 2075 LRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLV 2133
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG-DLTITNIQR 383
G VT C +G+P V W K+G P + R + +G L I+ +Q
Sbjct: 2134 SRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISKVQL 2185
Query: 384 SDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL-LKCKAT 442
+DAG + C A + AG L+V PP + N + V G+ + L C+A
Sbjct: 2186 ADAGIFTCVAASPAGVADRNFTLQV-----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR 2240
Query: 443 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAV 502
G PLP++SW+K+G + ++++ +LQ++ + D+GTY+CVA S +GE
Sbjct: 2241 GVPLPLVSWMKDGEPLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2296
Query: 503 LDVTESG--ATISKNYDLSDLPGPP 525
L V E + +LS PG P
Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAP 2321
Score = 177 bits (450), Expect = 5e-44
Identities = 165/568 (29%), Positives = 243/568 (42%), Gaps = 60/568 (10%)
Query: 30 PPRIVEHP--SDVIVSK-GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
PP I + S +VS+ GE T+ C G P + W KDG + P S R LL
Sbjct: 2119 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 2171
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL---LRDDFRQNPTDVV 143
GS LRI + D G + CVA + G A RN +L+V + L QN DVV
Sbjct: 2172 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 2226
Query: 144 VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTC 203
V G L C+ RG P P + W KD + + +G L + D+G Y+C
Sbjct: 2227 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 2282
Query: 204 VGTNMVGERDSDPAELTVFERPTF--LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 261
V + GE +LTV E P +P + +E C QG PQP + W KD
Sbjct: 2283 VAVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 2341
Query: 262 DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPR 321
L R + + LR++ D G Y C+AE+ G +E S + V+APP +V PR
Sbjct: 2342 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 2395
Query: 322 DQIVAQGRT---VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LT 377
G + C + P P + W ++G Q ++ G L
Sbjct: 2396 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIV--------LQEDAHTQFPERGRFLQ 2447
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 437
+ + +D+G Y C A AGS ++E+ V P I GP ++V+ TALL
Sbjct: 2448 LQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALL 2501
Query: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C+A G P P++SW K+ R PR I +G+L+I+ + D G Y C+A++S+G
Sbjct: 2502 PCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2561
Query: 498 SWSAVLDVTESGATISKNYDLS-----------DLPGPPSKPQVTDVTKNSVTLSWQPGT 546
L V E A +L+ + G P V + Q G
Sbjct: 2562 RQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGA 2621
Query: 547 PGTLPASAYIIEAFSQSVSNSWQTVANH 574
LP++A ++ A S ++ V ++
Sbjct: 2622 YRLLPSNALLLTAPGPQDSAQFECVVSN 2649
Score = 170 bits (431), Expect = 8e-42
Identities = 134/485 (27%), Positives = 201/485 (41%), Gaps = 36/485 (7%)
Query: 30 PPRIVE--HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I + P+++ ++ G P L C A+G P P I W+KDG+ + +++ R+ R+L
Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 2361
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR-QNPTDVVVAA 146
D G Y C+A + G A+ ++ + V + + P VV A
Sbjct: 2362 ----------------DAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLA 2404
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRI-DDKEERISIRGGKLMISNTRKSDAGMYTCVG 205
+LEC P P I W +D + + +D + RG L + +D+G Y+C
Sbjct: 2405 PGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA 2463
Query: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL 265
N G S + + PT P V + CQ G P P V W+KD L
Sbjct: 2464 RNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL 2522
Query: 266 -PRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ 323
PR R++I + +LRI+ ++ D G Y+C+A N G L V PP P +
Sbjct: 2523 DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 2582
Query: 324 IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR 383
+ PCE G+P+P V W K+G Q L F Q + P+ L +T
Sbjct: 2583 TLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAPGP 2637
Query: 384 SDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATG 443
D+ + C G Q+ V PP I + T+ + +L C +TG
Sbjct: 2638 QDSAQFECVVSNEVGEAHRLYQVTV------HVPPTIADDQTDFTVTMMAPVVLTCHSTG 2691
Query: 444 DPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVL 503
P P +SW K G R + G L+I G YTC A +S+G L
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2751
Query: 504 DVTES 508
V S
Sbjct: 2752 TVQAS 2756
Score = 169 bits (429), Expect = 1e-41
Identities = 138/489 (28%), Positives = 207/489 (42%), Gaps = 47/489 (9%)
Query: 30 PPRIV---EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
PP+I E P+ V V + TL C A G+P PT+ W +DG+ V + L
Sbjct: 1064 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 1118
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ-NP-TDVVV 144
G + R G Y CVA N G A R L V + + +P T++
Sbjct: 1119 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLTNITA 1173
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGG-KLMISNTRKSDAGMYTC 203
A P L C+ G P P I W + + + E+ + GG L ++ T++ D+G+Y+C
Sbjct: 1174 ALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSC 1232
Query: 204 VGTNMVGERDSDPAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKD 261
+ +N GE + + V P+ + +V VL+ + C V G PQP + W KD
Sbjct: 1233 LASNEAGEARRN-FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 1291
Query: 262 DADLPRG--RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR 319
L RG + D L++ + + G Y CIA N VG+ L+V P +
Sbjct: 1292 GRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 1351
Query: 320 PRDQI-----VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP-T 373
D V ++ CE P P + W K+G+ P + + + P T
Sbjct: 1352 AEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLPGT 1403
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT----- 428
L I N Q+ DAG Y C G + +EV PP I P +
Sbjct: 1404 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLGEVGVKEV 1458
Query: 429 -LAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487
V+ T L+C++ P P I W K+G + E LQI+ ++SD+G Y
Sbjct: 1459 KTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYL 1518
Query: 488 CVATSSSGE 496
CVAT+ +GE
Sbjct: 1519 CVATNVAGE 1527
Score = 168 bits (426), Expect = 3e-41
Identities = 146/486 (30%), Positives = 206/486 (42%), Gaps = 34/486 (6%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I P + V + TL C A G P P + W+K + V S + S
Sbjct: 694 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 746
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
LRI + S D GSY CVA N G R L V + V P
Sbjct: 747 GRVLRIEQAQLS--DAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTP 803
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEE---RISIRGGKLMISNTRKSDAGMYTCVGT 206
L C G P PT+ W KD + ++ G L +++ R SD+G Y+CV
Sbjct: 804 VRLTCN-ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 862
Query: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL- 265
+ VGE D L V P+ L +N V+ E+V CQ P P + W KD L
Sbjct: 863 SAVGE-DRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 921
Query: 266 PR-GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
PR G + D L++ + D G Y C A N+ G+ E L V P F +R +
Sbjct: 922 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTL 981
Query: 325 -VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT-ITNIQ 382
V +G + CE +G P P + W+K+G P + VS G L + Q
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 1035
Query: 383 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII--LQGPANQTLAVDGTALLKCK 440
+ G Y C+ V G+ QLEV PP I + P ++ DG A L+C
Sbjct: 1036 LAQEGTYTCECSNVVGNSSQDLQLEV-----HVPPQIAGPREPPTQVSVVQDGVATLECN 1090
Query: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQG-TLQIKNLRISDTGTYTCVATSSSGETSW 499
ATG P P ++W ++G G + +Q QG +L ++ + + TG Y+CVA + +G
Sbjct: 1091 ATGKPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAER 1149
Query: 500 SAVLDV 505
L V
Sbjct: 1150 KFELSV 1155
Score = 165 bits (417), Expect = 3e-40
Identities = 147/529 (27%), Positives = 220/529 (41%), Gaps = 47/529 (8%)
Query: 26 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL 85
Q PP I+ +V V E L C++ P P + W+KDG +E PR L
Sbjct: 875 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 929
Query: 86 PSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR-NASLEVALLRDDFRQNPTDVVV 144
+L + R D G Y C A N G + N ++ VA + R++ T + V
Sbjct: 930 ADKALLQV----DRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFP-LRESHT-LTV 983
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRGGKLMISNTRKSDAGMY 201
G P L C+ RG P P I W+KD + + + +S G L + + + G Y
Sbjct: 984 REGHPTSLSCEC-RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTY 1042
Query: 202 TCVGTNMVGERDSDPAELTVFERPTFL--RRPINQV-VLEEEAVEFRCQVQGDPQPTVRW 258
TC +N+VG D +L V P R P QV V+++ C G P PTV W
Sbjct: 1043 TCECSNVVGNSSQD-LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTW 1101
Query: 259 KKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 316
++D + G +L +++ + G Y C+AEN G+ E L+V PP+
Sbjct: 1102 ERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1161
Query: 317 V--VRPRDQIVAQGRT-VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
+ + P I A + +T CE G P PA+ W + +P P +
Sbjct: 1162 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRG--------EEPVSPGEDTYLLAG 1213
Query: 374 G-DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 432
G L +T Q D+G Y C A AG +EV PP I + +D
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV-----PPSIENEDLEEVIKVLD 1268
Query: 433 G-TALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVAT 491
G TA L C TG P P ++W K+G D + LQ+ +S G Y+C+A
Sbjct: 1269 GQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 1328
Query: 492 SSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540
++ GE + L V + + D +D +VT N ++L
Sbjct: 1329 NAVGEKTKHFQLSVLLAPTILGGAEDSAD-------EEVTVTVNNPISL 1370
Score = 158 bits (399), Expect = 4e-38
Identities = 131/477 (27%), Positives = 195/477 (40%), Gaps = 39/477 (8%)
Query: 42 VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRS 101
+ + P L C P P + WY++ + + + +L G + + +V +
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS-----VLQGGRVLQIPLVRAENA 1625
Query: 102 KPDEGSYVCVARNYLGEAVSRNASLEVA--LLRDDFRQNPTDVVVAAGEPAILECQPPRG 159
G Y C A N +GE L + ++ D + +V V A L+C P G
Sbjct: 1626 ----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALG 1680
Query: 160 HPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTCVGTNMVGERDSDPAE 218
+P PTI W ++ + + G+ L +S +DA Y CV N G +
Sbjct: 1681 NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEK-LFT 1739
Query: 219 LTVFERPTFLRRPINQVV-LEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR--YDIKDD 275
L V P + QV + +V C V P P V W KD L G + +
Sbjct: 1740 LRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT 1799
Query: 276 YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ----IVAQGRTV 331
+TL++ + +D G Y C A N G+ + L+V PP F PR +V G
Sbjct: 1800 HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 1859
Query: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYI 390
CET P+P V W K+G QP R G L I Q SD G Y
Sbjct: 1860 VLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 1911
Query: 391 CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA-VDGTAL-LKCKATGDPLPV 448
C+ VAG + T LT + PP + P +T++ V G+ L L C +G P P
Sbjct: 1912 CKVSNVAGEAVR------TFTLTVQVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPT 1964
Query: 449 ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
++WLK+ + G LQ+ L+ + GTYTCVA ++ E V+ V
Sbjct: 1965 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAV 2021
Score = 154 bits (389), Expect = 6e-37
Identities = 138/508 (27%), Positives = 210/508 (41%), Gaps = 69/508 (13%)
Query: 30 PPRIVEHPSDVIVS--KGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I + ++ G+ L C G P P + W+KDG + +H + P
Sbjct: 1252 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 1306
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR---NASLEVALLRDDFRQNPTDVVV 144
G L L+++ S G Y C+A N +GE + L +L +V V
Sbjct: 1307 GVL--LQVLQANLSSA--GHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 1362
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTC 203
P L C+ P P I W KD + + G L I N +K DAG YTC
Sbjct: 1363 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1421
Query: 204 VGTNMVGERDSDPAELTVFERPTFLRR-PINQVVLEE------EAVEFRCQVQGDPQPTV 256
V TN +GE + + V P+ + P+ +V ++E + C+ P PT+
Sbjct: 1422 VVTNELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTI 1480
Query: 257 RWKKDDADL-PRGRYDIKDD-YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
RW KD + P R + + L+I+ T +D G Y+C+A N G+ + + ++ PP
Sbjct: 1481 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1540
Query: 315 QFV----------VRPRDQIVAQGRT----------VTFPCETKGNPQPAVFWQKEGSQN 354
F + R++ G T C+T P P + W +E
Sbjct: 1541 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE---- 1596
Query: 355 LLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413
+QP SV G L I ++ +AG Y C+A G +L V
Sbjct: 1597 ----DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 1649
Query: 414 DRPPPIILQGPANQ-----TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQ 468
PP+IL G + T+ T L+C A G+P+P ISWL+ G F PR +
Sbjct: 1650 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPF-SPSPRLQVL 1704
Query: 469 EQG-TLQIKNLRISDTGTYTCVATSSSG 495
E G LQ+ ++D +Y CVA + +G
Sbjct: 1705 EDGQVLQVSTAEVADAASYMCVAENQAG 1732
Score = 153 bits (386), Expect = 1e-36
Identities = 120/384 (31%), Positives = 173/384 (45%), Gaps = 30/384 (7%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I D+ ++G L CKA G P P I W KDG+ V + PSG
Sbjct: 2846 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 2901
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
L ++ + G+ D G+Y C A N +G A R L + +L F P D + G+
Sbjct: 2902 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 2954
Query: 150 AILECQPPRGHPEPTIYWK-KDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 208
L C RG P P I W D+ + E+ G L + + D+G Y C N
Sbjct: 2955 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDG--GSTLQRAAVSREDSGTYVCWAENR 3011
Query: 209 VGERDSDPAELTVFERPTFLRRPINQVVLEEE-AVEFRCQVQGDPQPTVRWKKDDADLPR 267
VG R + + V E P + +V +++ C V+GDP P + W KD L R
Sbjct: 3012 VG-RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-R 3069
Query: 268 G---RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
G R+ +++ +L I +T D G Y C+AEN +G + L +++ P F V P+D
Sbjct: 3070 GSHLRHQLQNG-SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3128
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS 384
V G V C+ G P P + W + G QP + + R P G L + N++
Sbjct: 3129 VRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVETG 3180
Query: 385 DAGYYICQALTVAGSILAKAQLEV 408
DAG Y C A + GS A+A L V
Sbjct: 3181 DAGTYDCVAHNLLGSATARAFLVV 3204
Score = 147 bits (371), Expect = 7e-35
Identities = 137/495 (27%), Positives = 203/495 (41%), Gaps = 58/495 (11%)
Query: 30 PPRIV--EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP+++ E V G+P L C+A G P PTI+W ++G E + +
Sbjct: 496 PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQVASQ 550
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA-- 145
G+ + V S G + C A N G A A +EV++ ++ +V +
Sbjct: 551 GTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSV-HGEWAPGVLEVPIGQY 602
Query: 146 -------AGEPAILECQPP--RG---HPEPTIY--WKKDKVRIDDKEERISIRGG---KL 188
+ PA C PP RG HP+P + W + + I + L
Sbjct: 603 HWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPL 659
Query: 189 MISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQV 248
I D G+YTC TN+ GE + A L V P P+N+ VLE +V C
Sbjct: 660 QIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECLA 718
Query: 249 QGDPQPTVRWKKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA 306
G P P V W K + G D LRI++ +D G+Y C+A N G E
Sbjct: 719 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 778
Query: 307 TLTVRAPPQFVVRPR-DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPN 365
L V PP+ + P V V C G P P + W K+G+ P P
Sbjct: 779 GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN--------PVSPA 830
Query: 366 SR--CSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422
V P G LT+ + + SD+G Y C A++ G L+V PP IL
Sbjct: 831 GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMPPSILG 884
Query: 423 GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISD 482
N ++ + + L+C++ P PV+SW K+G R ++ LQ+ + D
Sbjct: 885 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWD 944
Query: 483 TGTYTCVATSSSGET 497
G YTC A + +G +
Sbjct: 945 AGHYTCEALNQAGRS 959
Score = 146 bits (369), Expect = 1e-34
Identities = 135/509 (26%), Positives = 200/509 (39%), Gaps = 69/509 (13%)
Query: 30 PPRIVEHPSDVIVS--KGEPTTLNCKAEGRPTPTIEWYKDGERV-----------ETDKD 76
PP I E VS G+ TL C A G P P I W KD + V +
Sbjct: 94 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 153
Query: 77 DPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR 136
HR+L SL F RI GR + + G + A L F
Sbjct: 154 QVGGHRLLDEGQSLHFPRIQPGRSGRRGAQA---------GGSAQTKAPWXAGLA--GFE 202
Query: 137 QNPT-------------------DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDK 177
Q PT +V+ AG L+C G P P + W KD+ +
Sbjct: 203 QFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPG 261
Query: 178 EERISIR--GGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFL--RRPIN 233
+ ++ G L I+ + D G Y CV + G++ D +L V PT
Sbjct: 262 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD-FQLRVHAPPTIWGSNETGE 320
Query: 234 QVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDI--KDDYTLRIKKTMSTDEGTY 291
V+E+ V+ C+ +G P P + W KD A LP + + L++ + S+D G Y
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVY 380
Query: 292 MCIAENRVGKMEASATLTVRAPPQFVV---RPRDQIVAQGRTVTFPCETKGNPQPAVFWQ 348
C A N VG E + L V PP RP GR V C +G+P P + W
Sbjct: 381 TCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWH 440
Query: 349 KEGSQNLLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLE 407
EG P ++ + G L + + + +G Y C A + AG + + +E
Sbjct: 441 HEGL--------PVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 492
Query: 408 VTDVLTDRPPPIILQGPANQTLAVDGTAL-LKCKATGDPLPVISWLKEGFTFPGRDPRAT 466
V PP +++ Q + G L L C+A+G P+P I WL+ G
Sbjct: 493 V-----QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQV 547
Query: 467 IQEQGTLQIKNLRISDTGTYTCVATSSSG 495
+ TL I ++ + +G + C AT+ +G
Sbjct: 548 ASQGTTLHIDHVELDHSGLFACQATNEAG 576
Score = 145 bits (365), Expect = 3e-34
Identities = 148/507 (29%), Positives = 208/507 (41%), Gaps = 68/507 (13%)
Query: 45 GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPD 104
G P L C A G P+PT+ W+ +G V + L GS+ L +
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEGLPVAESNES-----RLETDGSVLRLE----SPGEAS 470
Query: 105 EGSYVCVARNYLGEAVSRNASLEVA-----LLRDDFRQNPTDVVVAAGEPAILECQPPRG 159
G Y CVA + GEAV + S+EV L+ + Q V G+P L CQ G
Sbjct: 471 SGLYSCVASSPAGEAVLQY-SVEVQVPPQLLVAEGLGQ----VTTIVGQPLELPCQAS-G 524
Query: 160 HPEPTIYWKKDKVRIDDKEE-RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE 218
P PTI W ++ ++ +++ +G L I + +G++ C TN G ++ E
Sbjct: 525 SPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE-VE 583
Query: 219 LTVFER--PTFLRRPINQVVLEEE---AVEFRCQ---------------VQGDPQPTVRW 258
++V P L PI Q E + C V+G P W
Sbjct: 584 VSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLW 643
Query: 259 KKDDADLPRG---RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
+ P G Y + L+I+K DEG Y C A N G+ + L V PP
Sbjct: 644 GE-----PTGIPVAYSLPPP--LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN 696
Query: 316 FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 375
P ++ V + +VT C G P P V W K +QP +VS G
Sbjct: 697 IEPGPVNKAVLENASVTLECLASGVPPPDVSWFK--------GHQPVSSWMGVTVSVDGR 748
Query: 376 -LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 434
L I Q SDAG Y C A VAGS + L V + PP I L + V+
Sbjct: 749 VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV-----NVPPRITLPPSLPGPVLVNTP 803
Query: 435 ALLKCKATGDPLPVISWLKEGF-TFPGRDPRATIQEQG-TLQIKNLRISDTGTYTCVATS 492
L C ATG P P + WLK+G P P + G L + + R SD+G Y+CVA S
Sbjct: 804 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 863
Query: 493 SSGETSWSAVLDVTESGATISKNYDLS 519
+ GE VL V + + + ++S
Sbjct: 864 AVGEDRQDVVLQVHMPPSILGEELNVS 890
Score = 142 bits (359), Expect = 2e-33
Identities = 133/494 (26%), Positives = 203/494 (41%), Gaps = 54/494 (10%)
Query: 30 PPRI--VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I +V V + L C+A G PTP I W+KDG + P S +++
Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 362
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEA-VSRNASLEVALLRDDFRQNPTDVVVAA 146
G ++ GR D G Y C A N +G A + + V + P V A
Sbjct: 363 GG---RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 419
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRI-DDKEERISIRGGKLMISNTRKSDAGMYTCVG 205
G P LEC RGHP PT+ W + + + + E R+ G L + + ++ +G+Y+CV
Sbjct: 420 GRPVALEC-VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478
Query: 206 TNMVGERDSDPAELTVFERPTFLRRPINQV-VLEEEAVEFRCQVQGDPQPTVRWKKD--D 262
++ GE + + + QV + + +E CQ G P PT++W ++
Sbjct: 479 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 538
Query: 263 ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVR---APPQFVVR 319
A+ G TL I G + C A N G A ++V AP V
Sbjct: 539 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 598
Query: 320 PRDQIVAQGRTVTFP--CETK------GNPQPAVF--WQKEGSQNLLFPNQPQQPNSRCS 369
+FP C+ +P+P + W GS +P S
Sbjct: 599 IGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS----LWGEPTGIPVAYS 654
Query: 370 VSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL 429
+ P L I + D G Y C A +AG + L+V PP I GP N+ +
Sbjct: 655 LPP--PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAV 706
Query: 430 AVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP-----RATIQEQG-TLQIKNLRISDT 483
+ + L+C A+G P P +SW F G P T+ G L+I+ ++SD
Sbjct: 707 LENASVTLECLASGVPPPDVSW------FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDA 760
Query: 484 GTYTCVATSSSGET 497
G+Y CVA++ +G T
Sbjct: 761 GSYRCVASNVAGST 774
Score = 142 bits (358), Expect = 2e-33
Identities = 158/609 (25%), Positives = 240/609 (39%), Gaps = 62/609 (10%)
Query: 39 DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHG 98
+V+ G L C G PTP +EW KD + V H + G + LRI
Sbjct: 226 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG----GPHLQVQEDGQV--LRITGS 279
Query: 99 RRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPR 158
DEG Y CVA + G+ +R+ L V + N T V + + R
Sbjct: 280 HVG--DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEAR 336
Query: 159 GHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTCVGTNMVGERDSDPA 217
G P P I W KD + + + RGG+ L + + SDAG+YTC +N VG +
Sbjct: 337 GVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEK-AT 395
Query: 218 ELTVFERPTFL---RRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD---ADLPRGRYD 271
L V+ PT RP + V C +G P PT+ W + A+ R +
Sbjct: 396 RLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLE 455
Query: 272 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP--RDQIVAQGR 329
D LR++ G Y C+A + G+ ++ V+ PPQ +V G+
Sbjct: 456 -TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQ 514
Query: 330 TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG-DLTITNIQRSDAGY 388
+ PC+ G+P P + W + G +P + + V+ G L I +++ +G
Sbjct: 515 PLELPCQASGSPVPTIQWLQNG--------RPAEELAGVQVASQGTTLHIDHVELDHSGL 566
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
+ CQA AG+ A A++EV+ + P +L+ P Q A DP
Sbjct: 567 FACQATNEAGT--AGAEVEVS--VHGEWAPGVLEVPIGQ-YHWGXEHHSSFPAACDPPVH 621
Query: 449 ISW-------LKEGFTFPGR---DPR---ATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
W L EG+ PG +P LQI+ + + D G YTC AT+ +G
Sbjct: 622 RGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 681
Query: 496 ETSWSAVLDV----------TESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 545
E+ L V + + L L P V+ + SW G
Sbjct: 682 ESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWM-G 740
Query: 546 TPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSD 605
++ IE S + S++ VA++V + GLR N R P L
Sbjct: 741 VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV----PPRITLPPSLPG 796
Query: 606 PSPMSDPVR 614
P ++ PVR
Sbjct: 797 PVLVNTPVR 805
Score = 139 bits (349), Expect = 2e-32
Identities = 119/421 (28%), Positives = 173/421 (41%), Gaps = 46/421 (10%)
Query: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEP 163
DEG Y C A N GE+ R +L+V L+ + P + V LEC G P P
Sbjct: 668 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECL-ASGVPPP 724
Query: 164 TIYWKKDKVRIDD-KEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE-------RDSD 215
+ W K + +S+ G L I + SDAG Y CV +N+ G R +
Sbjct: 725 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 784
Query: 216 PAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL-PRGRYDIK- 273
P +T+ P L P VL V C G P PT+ W KD + P G ++
Sbjct: 785 PPRITL---PPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 837
Query: 274 --DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 331
L + ++D G Y C+A + VG+ L V PP + + V +V
Sbjct: 838 FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESV 897
Query: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS---DAGY 388
C++ P P + W K+G +P +P R V + D + + R+ DAG+
Sbjct: 898 ALECQSHAMPPPVLSWWKDG--------RPLEP--RPGVHLSADKALLQVDRADVWDAGH 947
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
Y C+AL AG L V P L+ T+ L C+ G P P
Sbjct: 948 YTCEALNQAGRSEKHYNLNVWVA-----PVFPLRESHTLTVREGHPTSLSCECRGVPFPK 1002
Query: 449 ISWLKEGFTFPGRDPRATIQEQGT----LQIKNLRISDTGTYTCVATSSSGETSWSAVLD 504
ISW K+G PG A +Q L + +++ GTYTC ++ G +S L+
Sbjct: 1003 ISWRKDGQPLPGEG--AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLE 1060
Query: 505 V 505
V
Sbjct: 1061 V 1061
Score = 122 bits (307), Expect = 2e-27
Identities = 135/487 (27%), Positives = 190/487 (39%), Gaps = 68/487 (13%)
Query: 52 CKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCV 111
C G P P + W K G E P +L GSLF + S D G Y C
Sbjct: 24 CGTHGTPKPQVTWRK-GPSSEPLHGQPGV--AVLEEGSLFLASV-----SPADSGDYECQ 75
Query: 112 ARNYLGEAVSRNASLEVAL---LRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWK 168
A N +G + SR A L V + +R+D R+ +V AG+ LEC G P P I W
Sbjct: 76 ATNEVG-STSRRAKLVVYVPPSIREDGRK--ANVSGMAGQSLTLECD-ANGFPVPEIVWL 131
Query: 169 KDKVRI----------------DDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGER 212
KD + R+ G L + +G +
Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191
Query: 213 DSDPAELTVFER------------PTFLRRPINQVV--LEEEAVEFRCQVQGDPQPTVRW 258
A L FE+ P+ L Q V L VE +C G P P V W
Sbjct: 192 APWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 251
Query: 259 KKD-DADLPRGRY-DIKDD-YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
KD LP G + +++D LRI + DEG Y C+A + G+ L V APP
Sbjct: 252 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 311
Query: 316 F--VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
+ V + V CE +G P P + W K+G+ L P + +R
Sbjct: 312 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA---LLPTSTKVVYTRGG---- 364
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
L + Q SDAG Y C+A G+ +L+V PP I +G + V
Sbjct: 365 RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV------YVPPTI-EGAGGRPYVVKA 417
Query: 434 TA----LLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCV 489
A L+C A G P P +SW EG + + L++++ + +G Y+CV
Sbjct: 418 VAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV 477
Query: 490 ATSSSGE 496
A+S +GE
Sbjct: 478 ASSPAGE 484
Score = 112 bits (280), Expect = 2e-24
Identities = 88/282 (31%), Positives = 120/282 (42%), Gaps = 19/282 (6%)
Query: 37 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIV 96
P D + G+ L C A G PTP I W T D P + + G R
Sbjct: 2944 PGDRSLRLGDRLWLRCAARGSPTPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA 2995
Query: 97 HGRRSKPDEGSYVCVARNYLG--EAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
R D G+YVC A N +G +AVS E +L+ + +V G L+C
Sbjct: 2996 VSRE---DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSY---LVEPVGGSIQLDC 3049
Query: 155 QPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
RG P P I+W KD + + R ++ G L I T + DAG Y C+ N +G
Sbjct: 3050 VV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 3108
Query: 215 DPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIK 273
L + P F P + V + V RCQ G+P PT+ W + L R
Sbjct: 3109 -VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL 3167
Query: 274 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
D +L ++ + D GTY C+A N +G A A L VR PQ
Sbjct: 3168 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3209
Score = 40.4 bits (93), Expect = 0.012
Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 439 CKATGDPLPVISWLKEGFTFPGR-DPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C G P P ++W K + P P + E+G+L + ++ +D+G Y C AT+ G T
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 498 SWSAVLDV 505
S A L V
Sbjct: 84 SRRAKLVV 91
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 205 bits (521), Expect = 3e-52
Identities = 154/473 (32%), Positives = 213/473 (45%), Gaps = 38/473 (8%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P I P V VS + L C+A+G P P + W KD RV D PR +LP GSL
Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD--RVPLDPRSPRFE--ILPEGSL 3728
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-FRQNPTDVVVAAGEP 149
++ D G Y+C+A N G S ++ +L +P+++ + A P
Sbjct: 3729 RIQPVL-----AQDAGHYLCLASNSAG---SDRQGRDLRVLEPPAIAPSPSNLTLTAHTP 3780
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR---GGKLMISNTRKSDAGMYTCVGT 206
A+L C+ G P+P + W KD ++D + ++ + R L+++ D+ + CV +
Sbjct: 3781 ALLPCEAS-GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVS 3839
Query: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL- 265
N VGE ++TV PT + V V C G P PTV W K A L
Sbjct: 3840 NEVGEAHR-LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 3898
Query: 266 PRGR-YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
RG Y + L I + + G Y C A N G LTV+A P VV+P +
Sbjct: 3899 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSV 3956
Query: 325 V--AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQ 382
V V PCE G P+P + WQKEG V P G L I +
Sbjct: 3957 VRAVAEEEVLLPCEASGIPRPTITWQKEGLN--------VATGVSTQVLPGGQLRIAHAS 4008
Query: 383 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKAT 442
DAG Y+C A AGS + K +L V + PP+I G + + A L CKA
Sbjct: 4009 PEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPCKAR 4062
Query: 443 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
G P P I+W K+G G + + TIQ G L +KNL D GTYTC A ++ G
Sbjct: 4063 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 4115
Score = 202 bits (513), Expect = 2e-51
Identities = 147/477 (30%), Positives = 214/477 (44%), Gaps = 31/477 (6%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P + PS V E L C+A G P PTI W K+G V T +LP G L
Sbjct: 3948 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 4002
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 150
RI H S D G+Y+C+A+N G A+ + V + D+ G A
Sbjct: 4003 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 4055
Query: 151 ILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTNMV 209
L C+ RG PEP I W KD + E + +I+ G+L++ N DAG YTC N V
Sbjct: 4056 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 4114
Query: 210 GERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 269
G R LT+ P F P ++ + + + RC +G P P + W +D + G
Sbjct: 4115 G-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 4173
Query: 270 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQ-G 328
+ TL+ D GTY+C AENRVG+ +A + + V+ P +V G
Sbjct: 4174 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 4233
Query: 329 RTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 388
++ C +G+P P + W K+G P + + G LTI +R DAG
Sbjct: 4234 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIHRTERDDAGR 4285
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
Y C A G +AK + +L + P+ P + T+ L+C+ATG+P P
Sbjct: 4286 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 4339
Query: 449 ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
I WL+ G T+ + G+L ++N+ D GTY CVA + G + A L V
Sbjct: 4340 IEWLQAGQPLRASRRLRTLPD-GSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 4395
Score = 182 bits (463), Expect = 1e-45
Identities = 167/626 (26%), Positives = 253/626 (40%), Gaps = 112/626 (17%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP + + V+V+ GE L C+A G P P + WY+ G + + S ++ +P+
Sbjct: 697 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 756
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR-DDFRQNPTDVVVAAGE 148
+ D G+Y C A N LG+A +A +++A+ + P DV V G
Sbjct: 757 ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 801
Query: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM-------- 200
A+L C+ G P PT+ W++ + + +R G S +R+ D+G+
Sbjct: 802 SALLACRAT-GRPPPTVTWRRGD------GQPLGLRLGAGRGSRSRQPDSGVLFFESVAP 854
Query: 201 -----YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQV-VLEEEAVEFRCQV-QGDPQ 253
Y C N+ G+ ++ + P + V VLE + V C V G P
Sbjct: 855 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914
Query: 254 PTVRWKKDDADLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA 312
P W KD LP G R+ I+ D +L + + + G Y C+A N G L V+
Sbjct: 915 PERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV 974
Query: 313 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKE-------------GSQNLLFPN 359
PP+ I +G + PC G P P + W KE + L
Sbjct: 975 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIA 1034
Query: 360 QPQQPNS------------------RCSVS---------------PTGDLTITNIQRSDA 386
QP ++ R SV+ P+G L + +Q D+
Sbjct: 1035 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDS 1094
Query: 387 GYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPL 446
G+Y C A AGS + L V + PP + GP + V L C A G+P
Sbjct: 1095 GHYECTASNPAGSASHRYVLGV------QVPPQVQPGPRVLKVLVGEALDLNCVAEGNPE 1148
Query: 447 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVT 506
P +SW K+G GR P QG++ +R SD G Y C A++S+G +W L V
Sbjct: 1149 PQLSWSKDGVVLQGRGP------QGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVL 1202
Query: 507 E---------SGATISKNYDLSDLPGP---PSKPQVT-DVTKNSVTLSWQPGTPGTLPAS 553
E SG + + LP P KPQVT +S L QPG L
Sbjct: 1203 EPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGV-AVLEEG 1261
Query: 554 AYIIEAFSQSVSNSWQTVA-NHVKTT 578
+ + + S + S ++ A N V +T
Sbjct: 1262 SLFLASVSPADSGDYECQATNEVGST 1287
Score = 182 bits (461), Expect = 3e-45
Identities = 134/486 (27%), Positives = 203/486 (41%), Gaps = 38/486 (7%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I PS++ ++ P L C+A G P P + W+KDG++++ + LLPS +
Sbjct: 3763 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNA 3820
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL-LRDDFRQNPTDVVVAAGE 148
L D + CV N +GEA + +V + + + TD V
Sbjct: 3821 LLLTA-----PGPQDSAQFECVVSNEVGEA---HRLYQVTVHVPPTIADDQTDFTVTMMA 3872
Query: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTN 207
P +L C G P PT+ W K ++ + + G L I AG YTC N
Sbjct: 3873 PVVLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN 3931
Query: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR 267
G LTV P P + EE V C+ G P+PT+ W+K+ ++
Sbjct: 3932 SAGVAHKH-VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT 3990
Query: 268 G-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA 326
G + LRI D G Y+CIA+N G L V+ PP D
Sbjct: 3991 GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT 4050
Query: 327 QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQ-PNSRCSVSPTGDLTITNIQRSD 385
+G PC+ +G+P+P + W K+G QP + ++ P+G+L + N++ D
Sbjct: 4051 EGSHAFLPCKARGSPEPNITWDKDG--------QPVSGAEGKFTIQPSGELLVKNLEGQD 4102
Query: 386 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 445
AG Y C A G + L + + P+ P +++L + L+C A G P
Sbjct: 4103 AGTYTCTAENAVGRARRRVHLTILVL------PVFTTLPGDRSLRLGDRLWLRCAARGSP 4156
Query: 446 LPVISWLKEGFTFPGRDPRATIQEQ---GTLQIKNLRISDTGTYTCVATSSSGETSWSAV 502
P I W T R + EQ TLQ + D+GTY C A + G T +
Sbjct: 4157 TPRIGW-----TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF 4211
Query: 503 LDVTES 508
+ V E+
Sbjct: 4212 VHVKEA 4217
Score = 179 bits (455), Expect = 1e-44
Identities = 150/505 (29%), Positives = 223/505 (44%), Gaps = 46/505 (9%)
Query: 37 PSD-VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95
P D V+V G+ L+C+ + P PT+ WYKDG+ + L G R+
Sbjct: 3038 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQ----RL 3088
Query: 96 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQ 155
D+G Y C N GEAV R +L V + V AG P +L C
Sbjct: 3089 EIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 3147
Query: 156 PPRGHPEPTIYWKKDKVRIDDKE-ERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
G P PT+ W KD++ ++ + RGG+L +S + + AG YTCV N E
Sbjct: 3148 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 3206
Query: 215 DPAELTVFERPTFLRRPI--NQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL-----PR 267
D + V P + VLE + V C+ G P P V W KD + L P
Sbjct: 3207 D-FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPH 3265
Query: 268 GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP---QFVVRPRDQI 324
R+ + D +L +K ++D G Y C+A N G+ T+ V PP Q +
Sbjct: 3266 LRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLV 3324
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG-DLTITNIQR 383
G VT C +G+P V W K+G P + R + +G L I+ +Q
Sbjct: 3325 SRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISKVQL 3376
Query: 384 SDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL-LKCKAT 442
+DAG + C A + AG L+V PP + N + V G+ + L C+A
Sbjct: 3377 ADAGIFTCVAASPAGVADRNFTLQV-----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR 3431
Query: 443 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAV 502
G PLP++SW+K+G + ++++ +LQ++ + D+GTY+CVA S +GE
Sbjct: 3432 GVPLPLVSWMKDGEPLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 3487
Query: 503 LDVTESG--ATISKNYDLSDLPGPP 525
L V E + +LS PG P
Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAP 3512
Score = 177 bits (450), Expect = 5e-44
Identities = 165/568 (29%), Positives = 243/568 (42%), Gaps = 60/568 (10%)
Query: 30 PPRIVEHP--SDVIVSK-GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
PP I + S +VS+ GE T+ C G P + W KDG + P S R LL
Sbjct: 3310 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 3362
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL---LRDDFRQNPTDVV 143
GS LRI + D G + CVA + G A RN +L+V + L QN DVV
Sbjct: 3363 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 3417
Query: 144 VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTC 203
V G L C+ RG P P + W KD + + +G L + D+G Y+C
Sbjct: 3418 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 3473
Query: 204 VGTNMVGERDSDPAELTVFERPTF--LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 261
V + GE +LTV E P +P + +E C QG PQP + W KD
Sbjct: 3474 VAVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 3532
Query: 262 DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPR 321
L R + + LR++ D G Y C+AE+ G +E S + V+APP +V PR
Sbjct: 3533 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 3586
Query: 322 DQIVAQGRT---VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LT 377
G + C + P P + W ++G Q ++ G L
Sbjct: 3587 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIV--------LQEDAHTQFPERGRFLQ 3638
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 437
+ + +D+G Y C A AGS ++E+ V P I GP ++V+ TALL
Sbjct: 3639 LQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALL 3692
Query: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C+A G P P++SW K+ R PR I +G+L+I+ + D G Y C+A++S+G
Sbjct: 3693 PCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 3752
Query: 498 SWSAVLDVTESGATISKNYDLS-----------DLPGPPSKPQVTDVTKNSVTLSWQPGT 546
L V E A +L+ + G P V + Q G
Sbjct: 3753 RQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGA 3812
Query: 547 PGTLPASAYIIEAFSQSVSNSWQTVANH 574
LP++A ++ A S ++ V ++
Sbjct: 3813 YRLLPSNALLLTAPGPQDSAQFECVVSN 3840
Score = 174 bits (440), Expect = 7e-43
Identities = 146/495 (29%), Positives = 210/495 (42%), Gaps = 59/495 (11%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P++ H S S+G ++C A G PTP I W ++ + ++ +D R H + G+L
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ---EDSRIH--VDAQGTL 662
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV-------V 143
+ + D G+Y C A N +G E L + +P V +
Sbjct: 663 IIQGV-----APEDAGNYSCQATNEVG------TDQETVTL---YYTDPPSVSAVNAVVL 708
Query: 144 VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTC 203
VA GE A+L C+ G P P + W + + + E S GKL I ++ DAG YTC
Sbjct: 709 VAVGEEAVLVCEAS-GVPPPRVIWYRGGLEMILAPEGSS--SGKLRIPAAQERDAGTYTC 765
Query: 204 VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 263
N +G+ ++ +L V P P + V + C+ G P PTV W++ D
Sbjct: 766 RAVNELGDASAE-IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDG 824
Query: 264 DLPRG---------RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RA 312
P G R D L + D+ Y+C A N GK++A A L V A
Sbjct: 825 Q-PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHA 883
Query: 313 PPQFVVRPRDQIVAQGRTVTFPCET-KGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVS 371
PPQ V +G+ V+ PC G P P W K+G +P P SR S+
Sbjct: 884 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG--------RPLPPGSRHSIR 935
Query: 372 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 431
G L + + AG Y C A AGS Q +++ PP I A +
Sbjct: 936 ADGSLHLDRALQEHAGRYSCVATNTAGS-----QHRDVELVVQVPPRI--HPTATHHITN 988
Query: 432 DGT-ALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVA 490
+G A L C A+G P P I+W KE R P + ++GTL I D G Y C A
Sbjct: 989 EGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTA 1048
Query: 491 TSSSGETSWSAVLDV 505
T++ G +S L V
Sbjct: 1049 TNTVGFSSQEMRLSV 1063
Score = 170 bits (431), Expect = 8e-42
Identities = 134/485 (27%), Positives = 201/485 (41%), Gaps = 36/485 (7%)
Query: 30 PPRIVE--HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I + P+++ ++ G P L C A+G P P I W+KDG+ + +++ R+ R+L
Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 3552
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR-QNPTDVVVAA 146
D G Y C+A + G A+ ++ + V + + P VV A
Sbjct: 3553 ----------------DAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLA 3595
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRI-DDKEERISIRGGKLMISNTRKSDAGMYTCVG 205
+LEC P P I W +D + + +D + RG L + +D+G Y+C
Sbjct: 3596 PGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA 3654
Query: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL 265
N G S + + PT P V + CQ G P P V W+KD L
Sbjct: 3655 RNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL 3713
Query: 266 -PRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ 323
PR R++I + +LRI+ ++ D G Y+C+A N G L V PP P +
Sbjct: 3714 DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 3773
Query: 324 IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR 383
+ PCE G+P+P V W K+G Q L F Q + P+ L +T
Sbjct: 3774 TLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAPGP 3828
Query: 384 SDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATG 443
D+ + C G Q+ V PP I + T+ + +L C +TG
Sbjct: 3829 QDSAQFECVVSNEVGEAHRLYQVTV------HVPPTIADDQTDFTVTMMAPVVLTCHSTG 3882
Query: 444 DPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVL 503
P P +SW K G R + G L+I G YTC A +S+G L
Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 3942
Query: 504 DVTES 508
V S
Sbjct: 3943 TVQAS 3947
Score = 169 bits (429), Expect = 1e-41
Identities = 138/489 (28%), Positives = 207/489 (42%), Gaps = 47/489 (9%)
Query: 30 PPRIV---EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
PP+I E P+ V V + TL C A G+P PT+ W +DG+ V + L
Sbjct: 2255 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 2309
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ-NP-TDVVV 144
G + R G Y CVA N G A R L V + + +P T++
Sbjct: 2310 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLTNITA 2364
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGG-KLMISNTRKSDAGMYTC 203
A P L C+ G P P I W + + + E+ + GG L ++ T++ D+G+Y+C
Sbjct: 2365 ALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSC 2423
Query: 204 VGTNMVGERDSDPAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKD 261
+ +N GE + + V P+ + +V VL+ + C V G PQP + W KD
Sbjct: 2424 LASNEAGEARRN-FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 2482
Query: 262 DADLPRG--RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR 319
L RG + D L++ + + G Y CIA N VG+ L+V P +
Sbjct: 2483 GRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 2542
Query: 320 PRDQI-----VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP-T 373
D V ++ CE P P + W K+G+ P + + + P T
Sbjct: 2543 AEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLPGT 2594
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQT----- 428
L I N Q+ DAG Y C G + +EV PP I P +
Sbjct: 2595 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLGEVGVKEV 2649
Query: 429 -LAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487
V+ T L+C++ P P I W K+G + E LQI+ ++SD+G Y
Sbjct: 2650 KTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYL 2709
Query: 488 CVATSSSGE 496
CVAT+ +GE
Sbjct: 2710 CVATNVAGE 2718
Score = 167 bits (423), Expect = 6e-41
Identities = 152/535 (28%), Positives = 213/535 (39%), Gaps = 85/535 (15%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRMLLP-SG 88
P++ E P DV V G L C+A GRP PT+ W + DG+ + R R P SG
Sbjct: 786 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 845
Query: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 148
LFF + + D+ YVC ARN G+ + + + V V G+
Sbjct: 846 VLFFESV-----APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ 900
Query: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGTN 207
P L C G P P +W KD R R SIR G L + + AG Y+CV TN
Sbjct: 901 PVSLPCIVLAGRPLPERHWLKDG-RPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN 959
Query: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD-DADLP 266
G + D EL V P + + E C G P PT+ W K+ +A
Sbjct: 960 TAGSQHRD-VELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS 1018
Query: 267 RG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRV-------------------------- 299
RG Y++ + TL I + + D G Y+C A N V
Sbjct: 1019 RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGL 1078
Query: 300 ----------------GKMEASAT-----------LTVRAPPQFVVRPRDQIVAQGRTVT 332
G E +A+ L V+ PPQ PR V G +
Sbjct: 1079 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALD 1138
Query: 333 FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQ 392
C +GNP+P + W K+G ++ + P G + I+ SDAG Y C+
Sbjct: 1139 LNCVAEGNPEPQLSWSKDG---VVLQGR----------GPQGSVHFAAIRTSDAGRYRCE 1185
Query: 393 ALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG-TALLKCKATGDPLPVISW 451
A AG + +L V + PP + V G A L C A G P P ++W
Sbjct: 1186 ASNSAGVDAWEVELRVLE-----PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTW 1240
Query: 452 LKEGFTFP-GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
K + P P + E+G+L + ++ +D+G Y C AT+ G TS A L V
Sbjct: 1241 RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 167 bits (423), Expect = 6e-41
Identities = 146/486 (30%), Positives = 205/486 (42%), Gaps = 34/486 (6%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I P + V + TL C A G P P + W+K + V S + S
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 1937
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
LRI + S D GSY CVA N G R L V + V P
Sbjct: 1938 GRVLRIEQAQLS--DAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTP 1994
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEE---RISIRGGKLMISNTRKSDAGMYTCVGT 206
L C G P PT+ W KD + ++ G L +++ R SD+G Y+CV
Sbjct: 1995 VRLTCN-ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 2053
Query: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL- 265
+ VGE D L V P+ L +N V+ E+V CQ P P + W KD L
Sbjct: 2054 SAVGE-DRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 2112
Query: 266 PR-GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
PR G + D L++ + D G Y C A N+ G E L V P F +R +
Sbjct: 2113 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 2172
Query: 325 -VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT-ITNIQ 382
V +G + CE +G P P + W+K+G P + VS G L + Q
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 2226
Query: 383 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII--LQGPANQTLAVDGTALLKCK 440
+ G Y C+ V G+ QLEV PP I + P ++ DG A L+C
Sbjct: 2227 LAQEGTYTCECSNVVGNSSQDLQLEV-----HVPPQIAGPREPPTQVSVVQDGVATLECN 2281
Query: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQG-TLQIKNLRISDTGTYTCVATSSSGETSW 499
ATG P P ++W ++G G + +Q QG +L ++ + + TG Y+CVA + +G
Sbjct: 2282 ATGKPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAER 2340
Query: 500 SAVLDV 505
L V
Sbjct: 2341 KFELSV 2346
Score = 165 bits (417), Expect = 3e-40
Identities = 147/529 (27%), Positives = 220/529 (41%), Gaps = 47/529 (8%)
Query: 26 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL 85
Q PP I+ +V V E L C++ P P + W+KDG +E PR L
Sbjct: 2066 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 2120
Query: 86 PSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR-NASLEVALLRDDFRQNPTDVVV 144
+L + R D G Y C A N G + N ++ VA + R++ T + V
Sbjct: 2121 ADKALLQV----DRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-LRESHT-LTV 2174
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRGGKLMISNTRKSDAGMY 201
G P L C+ RG P P I W+KD + + + +S G L + + + G Y
Sbjct: 2175 REGHPTSLSCEC-RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTY 2233
Query: 202 TCVGTNMVGERDSDPAELTVFERPTFL--RRPINQV-VLEEEAVEFRCQVQGDPQPTVRW 258
TC +N+VG D +L V P R P QV V+++ C G P PTV W
Sbjct: 2234 TCECSNVVGNSSQD-LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTW 2292
Query: 259 KKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 316
++D + G +L +++ + G Y C+AEN G+ E L+V PP+
Sbjct: 2293 ERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 2352
Query: 317 V--VRPRDQIVAQGRT-VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
+ + P I A + +T CE G P PA+ W + +P P +
Sbjct: 2353 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRG--------EEPVSPGEDTYLLAG 2404
Query: 374 G-DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 432
G L +T Q D+G Y C A AG +EV PP I + +D
Sbjct: 2405 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV-----PPSIENEDLEEVIKVLD 2459
Query: 433 G-TALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVAT 491
G TA L C TG P P ++W K+G D + LQ+ +S G Y+C+A
Sbjct: 2460 GQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 2519
Query: 492 SSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540
++ GE + L V + + D +D +VT N ++L
Sbjct: 2520 NAVGEKTKHFQLSVLLAPTILGGAEDSAD-------EEVTVTVNNPISL 2561
Score = 158 bits (399), Expect = 4e-38
Identities = 138/491 (28%), Positives = 200/491 (40%), Gaps = 46/491 (9%)
Query: 30 PPRIVEHPSDVIVS--KGEPTTLNCKAEGRPTPTIEWYKDGERV-----------ETDKD 76
PP I E VS G+ TL C A G P P I W KD + V +
Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 1357
Query: 77 DPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR 136
HR+L SL F RI G D G Y C A N G A R+ L V
Sbjct: 1358 QVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTA-QRDFHLLVLTPPSVLG 1411
Query: 137 QNPTDVVVA-AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR--GGKLMISNT 193
V+ AG L+C G P P + W KD+ + + ++ G L I+ +
Sbjct: 1412 AGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGS 1470
Query: 194 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFL--RRPINQVVLEEEAVEFRCQVQGD 251
D G Y CV + G++ D +L V PT V+E+ V+ C+ +G
Sbjct: 1471 HVGDEGRYQCVAFSPAGQQARD-FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGV 1529
Query: 252 PQPTVRWKKDDADLPRGRYDI--KDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 309
P P + W KD A LP + + L++ + S+D G Y C A N VG E + L
Sbjct: 1530 PTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLD 1589
Query: 310 VRAPPQFVV---RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS 366
V PP RP GR V C +G+P P + W EG P ++
Sbjct: 1590 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL--------PVAESN 1641
Query: 367 RCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 425
+ G L + + + +G Y C A + AG + + +EV PP +++
Sbjct: 1642 ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-----QVPPQLLVAEGL 1696
Query: 426 NQTLAVDGTAL-LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTG 484
Q + G L L C+A+G P+P I WL+ G + TL I ++ + +G
Sbjct: 1697 GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG 1756
Query: 485 TYTCVATSSSG 495
+ C AT+ +G
Sbjct: 1757 LFACQATNEAG 1767
Score = 158 bits (399), Expect = 4e-38
Identities = 131/477 (27%), Positives = 195/477 (40%), Gaps = 39/477 (8%)
Query: 42 VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRS 101
+ + P L C P P + WY++ + + + +L G + + +V +
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS-----VLQGGRVLQIPLVRAENA 2816
Query: 102 KPDEGSYVCVARNYLGEAVSRNASLEVA--LLRDDFRQNPTDVVVAAGEPAILECQPPRG 159
G Y C A N +GE L + ++ D + +V V A L+C P G
Sbjct: 2817 ----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALG 2871
Query: 160 HPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTCVGTNMVGERDSDPAE 218
+P PTI W ++ + + G+ L +S +DA Y CV N G +
Sbjct: 2872 NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEK-LFT 2930
Query: 219 LTVFERPTFLRRPINQVV-LEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR--YDIKDD 275
L V P + QV + +V C V P P V W KD L G + +
Sbjct: 2931 LRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT 2990
Query: 276 YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ----IVAQGRTV 331
+TL++ + +D G Y C A N G+ + L+V PP F PR +V G
Sbjct: 2991 HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 3050
Query: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYI 390
CET P+P V W K+G QP R G L I Q SD G Y
Sbjct: 3051 VLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 3102
Query: 391 CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA-VDGTAL-LKCKATGDPLPV 448
C+ VAG + T LT + PP + P +T++ V G+ L L C +G P P
Sbjct: 3103 CKVSNVAGEAVR------TFTLTVQVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPT 3155
Query: 449 ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
++WLK+ + G LQ+ L+ + GTYTCVA ++ E V+ V
Sbjct: 3156 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAV 3212
Score = 155 bits (391), Expect = 3e-37
Identities = 141/475 (29%), Positives = 197/475 (41%), Gaps = 34/475 (7%)
Query: 28 DFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
D PP++V P+ V VS GE L+C+ G + W +D + L
Sbjct: 515 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQ----LAD 569
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
SL I+ D G Y CVA N G V+R + + + + + G
Sbjct: 570 LSLEISGII-----PTDGGRYQCVASNANG--VTRASVWLLVREAPQVSIHTSSQHFSQG 622
Query: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKSDAGMYTCVGT 206
+ C G+P P I W ++ + + + RI + G L+I DAG Y+C T
Sbjct: 623 VEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 680
Query: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLE---EEAVEFRCQVQGDPQPTVRWKKDDA 263
N VG D + L + P+ +N VVL EEAV C+ G P P V W +
Sbjct: 681 NEVGT-DQETVTLYYTDPPSV--SAVNAVVLVAVGEEAV-LVCEASGVPPPRVIWYRGGL 736
Query: 264 DL---PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
++ P G K LRI D GTY C A N +G A L V PQ P
Sbjct: 737 EMILAPEGSSSGK----LRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELP 792
Query: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
RD V GR+ C G P P V W++ Q L SR +G L +
Sbjct: 793 RDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-RLGAGRGSRSRQPDSGVLFFES 851
Query: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 440
+ D Y+C+A V G + A+A+L VT PP I P + L +L
Sbjct: 852 VAPEDQAPYVCEARNVFGKVQAEARLIVTG---HAPPQIASSAPTVRVLEGQPVSLPCIV 908
Query: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
G PLP WLK+G P R +I+ G+L + G Y+CVAT+++G
Sbjct: 909 LAGRPLPERHWLKDGRPLP-PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 962
Score = 154 bits (389), Expect = 6e-37
Identities = 138/508 (27%), Positives = 210/508 (41%), Gaps = 69/508 (13%)
Query: 30 PPRIVEHPSDVIVS--KGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I + ++ G+ L C G P P + W+KDG + +H + P
Sbjct: 2443 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 2497
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR---NASLEVALLRDDFRQNPTDVVV 144
G L L+++ S G Y C+A N +GE + L +L +V V
Sbjct: 2498 GVL--LQVLQANLSSA--GHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 2553
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTC 203
P L C+ P P I W KD + + G L I N +K DAG YTC
Sbjct: 2554 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 2612
Query: 204 VGTNMVGERDSDPAELTVFERPTFLRR-PINQVVLEE------EAVEFRCQVQGDPQPTV 256
V TN +GE + + V P+ + P+ +V ++E + C+ P PT+
Sbjct: 2613 VVTNELGEAVKN-YHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTI 2671
Query: 257 RWKKDDADL-PRGRYDIKDD-YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
RW KD + P R + + L+I+ T +D G Y+C+A N G+ + + ++ PP
Sbjct: 2672 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 2731
Query: 315 QFV----------VRPRDQIVAQGRT----------VTFPCETKGNPQPAVFWQKEGSQN 354
F + R++ G T C+T P P + W +E
Sbjct: 2732 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE---- 2787
Query: 355 LLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413
+QP SV G L I ++ +AG Y C+A G +L V
Sbjct: 2788 ----DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 2840
Query: 414 DRPPPIILQGPANQ-----TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQ 468
PP+IL G + T+ T L+C A G+P+P ISWL+ G F PR +
Sbjct: 2841 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPF-SPSPRLQVL 2895
Query: 469 EQG-TLQIKNLRISDTGTYTCVATSSSG 495
E G LQ+ ++D +Y CVA + +G
Sbjct: 2896 EDGQVLQVSTAEVADAASYMCVAENQAG 2923
Score = 153 bits (387), Expect = 1e-36
Identities = 158/546 (28%), Positives = 214/546 (39%), Gaps = 67/546 (12%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP++ P + V GE LNC AEG P P + W KDG ++ P GS
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG----------PQGS 1168
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVV--AAG 147
+ F I D G Y C A N G + L V L + + T ++ AG
Sbjct: 1169 VHFAAI-----RTSDAGRYRCEASNSAG-VDAWEVELRV-LEPPHWGADETSGLLERVAG 1221
Query: 148 EPAILECQPPRGHPEPTIYWKK--DKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVG 205
E A L C P RG P+P + W+K + + + G L +++ +D+G Y C
Sbjct: 1222 ENASLPC-PARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQA 1280
Query: 206 TNMVGERDSDPAELTVFERPTFLR--RPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 263
TN VG S A+L V+ P+ R N + +++ C G P P + W KD
Sbjct: 1281 TNEVGS-TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 1339
Query: 264 -------------DLPRGRYD----IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA 306
DL G+ + + +L + D G Y C AEN+ G +
Sbjct: 1340 LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDF 1399
Query: 307 TLTVRAPPQFVVRPRDQIV--AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQP 364
L V PP + Q V G V C T G P P V W K+ QP P
Sbjct: 1400 HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD--------RQPVLP 1451
Query: 365 NS-RCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422
V G L IT D G Y C A + AG QL V PP I
Sbjct: 1452 GGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV------HAPPTIWG 1505
Query: 423 GPANQTLAV--DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480
+AV D L C+A G P P I+W K+G P + LQ+ +
Sbjct: 1506 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQS 1565
Query: 481 SDTGTYTCVATSSSGETSWSAVLDV----TESGATISKNYDLSDLPGPPSKPQVTDVTKN 536
SD G YTC A+++ G + LDV T GA + Y + + G P +
Sbjct: 1566 SDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAG-GRPYVVKAVAGRPVALECVARGHP 1624
Query: 537 SVTLSW 542
S TLSW
Sbjct: 1625 SPTLSW 1630
Score = 153 bits (386), Expect = 1e-36
Identities = 120/384 (31%), Positives = 173/384 (45%), Gaps = 30/384 (7%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I D+ ++G L CKA G P P I W KDG+ V + PSG
Sbjct: 4037 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 4092
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
L ++ + G+ D G+Y C A N +G A R L + +L F P D + G+
Sbjct: 4093 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 4145
Query: 150 AILECQPPRGHPEPTIYWK-KDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 208
L C RG P P I W D+ + E+ G L + + D+G Y C N
Sbjct: 4146 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDG--GSTLQRAAVSREDSGTYVCWAENR 4202
Query: 209 VGERDSDPAELTVFERPTFLRRPINQVVLEEE-AVEFRCQVQGDPQPTVRWKKDDADLPR 267
VG R + + V E P + +V +++ C V+GDP P + W KD L R
Sbjct: 4203 VG-RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-R 4260
Query: 268 G---RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
G R+ +++ +L I +T D G Y C+AEN +G + L +++ P F V P+D
Sbjct: 4261 GSHLRHQLQNG-SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 4319
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS 384
V G V C+ G P P + W + G QP + + R P G L + N++
Sbjct: 4320 VRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVETG 4371
Query: 385 DAGYYICQALTVAGSILAKAQLEV 408
DAG Y C A + GS A+A L V
Sbjct: 4372 DAGTYDCVAHNLLGSATARAFLVV 4395
Score = 151 bits (381), Expect = 5e-36
Identities = 143/482 (29%), Positives = 200/482 (41%), Gaps = 57/482 (11%)
Query: 45 GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPD 104
GE +L C A G P P + W K G E P +L GSLF + S D
Sbjct: 1221 GENASLPCPARGTPKPQVTWRK-GPSSEPLHGQPGV--AVLEEGSLFLASV-----SPAD 1272
Query: 105 EGSYVCVARNYLGEAVSRNASLEVAL---LRDDFRQNPTDVVVAAGEPAILECQPPRGHP 161
G Y C A N +G + SR A L V + +R+D R+ +V AG+ LEC G P
Sbjct: 1273 SGDYECQATNEVG-STSRRAKLVVYVPPSIREDGRK--ANVSGMAGQSLTLECDA-NGFP 1328
Query: 162 EPTIYWKKDKVRIDDK----------------EERISIRGGKLMISNTRKSDAGMYTCVG 205
P I W KD + R+ G L ++ D+G+Y+C
Sbjct: 1329 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA 1388
Query: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEA--VEFRCQVQGDPQPTVRWKKDDA 263
N G D L V P+ L Q VL VE +C G P P V W KD
Sbjct: 1389 ENQAGTAQRD-FHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQ 1447
Query: 264 D-LPRGRY-DIKDD-YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF--VV 318
LP G + +++D LRI + DEG Y C+A + G+ L V APP
Sbjct: 1448 PVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSN 1507
Query: 319 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
+ V + V CE +G P P + W K+G+ L P + +R L +
Sbjct: 1508 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA---LLPTSTKVVYTRGG----RQLQL 1560
Query: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA--- 435
Q SDAG Y C+A G+ +L+V PP I +G + V A
Sbjct: 1561 GRAQSSDAGVYTCKASNAVGAAEKATRLDVY------VPPTI-EGAGGRPYVVKAVAGRP 1613
Query: 436 -LLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS 494
L+C A G P P +SW EG + + L++++ + +G Y+CVA+S +
Sbjct: 1614 VALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPA 1673
Query: 495 GE 496
GE
Sbjct: 1674 GE 1675
Score = 147 bits (371), Expect = 7e-35
Identities = 137/495 (27%), Positives = 203/495 (41%), Gaps = 58/495 (11%)
Query: 30 PPRIV--EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP+++ E V G+P L C+A G P PTI+W ++G E + +
Sbjct: 1687 PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQVASQ 1741
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA-- 145
G+ + V S G + C A N G A A +EV++ ++ +V +
Sbjct: 1742 GTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSV-HGEWAPGVLEVPIGQY 1793
Query: 146 -------AGEPAILECQPP--RG---HPEPTIY--WKKDKVRIDDKEERISIRGG---KL 188
+ PA C PP RG HP+P + W + + I + L
Sbjct: 1794 HWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPL 1850
Query: 189 MISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQV 248
I D G+YTC TN+ GE + A L V P P+N+ VLE +V C
Sbjct: 1851 QIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECLA 1909
Query: 249 QGDPQPTVRWKKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA 306
G P P V W K + G D LRI++ +D G+Y C+A N G E
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 1969
Query: 307 TLTVRAPPQFVVRPR-DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPN 365
L V PP+ + P V V C G P P + W K+G+ P P
Sbjct: 1970 GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN--------PVSPA 2021
Query: 366 SR--CSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422
V P G LT+ + + SD+G Y C A++ G L+V PP IL
Sbjct: 2022 GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMPPSILG 2075
Query: 423 GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISD 482
N ++ + + L+C++ P PV+SW K+G R ++ LQ+ + D
Sbjct: 2076 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWD 2135
Query: 483 TGTYTCVATSSSGET 497
G YTC A + +G +
Sbjct: 2136 AGHYTCEALNQAGHS 2150
Score = 145 bits (365), Expect = 3e-34
Identities = 148/507 (29%), Positives = 208/507 (41%), Gaps = 68/507 (13%)
Query: 45 GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPD 104
G P L C A G P+PT+ W+ +G V + L GS+ L +
Sbjct: 1611 GRPVALECVARGHPSPTLSWHHEGLPVAESNES-----RLETDGSVLRLE----SPGEAS 1661
Query: 105 EGSYVCVARNYLGEAVSRNASLEVA-----LLRDDFRQNPTDVVVAAGEPAILECQPPRG 159
G Y CVA + GEAV + S+EV L+ + Q V G+P L CQ G
Sbjct: 1662 SGLYSCVASSPAGEAVLQY-SVEVQVPPQLLVAEGLGQ----VTTIVGQPLELPCQAS-G 1715
Query: 160 HPEPTIYWKKDKVRIDDKEE-RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE 218
P PTI W ++ ++ +++ +G L I + +G++ C TN G ++ E
Sbjct: 1716 SPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE-VE 1774
Query: 219 LTVFER--PTFLRRPINQVVLEEE---AVEFRCQ---------------VQGDPQPTVRW 258
++V P L PI Q E + C V+G P W
Sbjct: 1775 VSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLW 1834
Query: 259 KKDDADLPRG---RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
+ P G Y + L+I+K DEG Y C A N G+ + L V PP
Sbjct: 1835 GE-----PTGIPVAYSLPPP--LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN 1887
Query: 316 FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 375
P ++ V + +VT C G P P V W K +QP +VS G
Sbjct: 1888 IEPGPVNKAVLENASVTLECLASGVPPPDVSWFK--------GHQPVSSWMGVTVSVDGR 1939
Query: 376 -LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 434
L I Q SDAG Y C A VAGS + L V + PP I L + V+
Sbjct: 1940 VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV-----NVPPRITLPPSLPGPVLVNTP 1994
Query: 435 ALLKCKATGDPLPVISWLKEGF-TFPGRDPRATIQEQG-TLQIKNLRISDTGTYTCVATS 492
L C ATG P P + WLK+G P P + G L + + R SD+G Y+CVA S
Sbjct: 1995 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 2054
Query: 493 SSGETSWSAVLDVTESGATISKNYDLS 519
+ GE VL V + + + ++S
Sbjct: 2055 AVGEDRQDVVLQVHMPPSILGEELNVS 2081
Score = 143 bits (361), Expect = 1e-33
Identities = 164/630 (26%), Positives = 248/630 (39%), Gaps = 70/630 (11%)
Query: 26 QEDFPPRIVEHPS--------DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDD 77
Q DF ++ PS +V+ G L C G PTP +EW KD + V
Sbjct: 1396 QRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGP- 1454
Query: 78 PRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ 137
H + G + LRI DEG Y CVA + G+ +R+ L V +
Sbjct: 1455 ---HLQVQEDGQV--LRITGSHVG--DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGS 1506
Query: 138 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKS 196
N T V + + RG P P I W KD + + + RGG+ L + + S
Sbjct: 1507 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSS 1566
Query: 197 DAGMYTCVGTNMVGERDSDPAELTVFERPTFLR---RPINQVVLEEEAVEFRCQVQGDPQ 253
DAG+YTC +N VG + L V+ PT RP + V C +G P
Sbjct: 1567 DAGVYTCKASNAVGAAEK-ATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 1625
Query: 254 PTVRWKKDD---ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
PT+ W + A+ R + D LR++ G Y C+A + G+ ++ V
Sbjct: 1626 PTLSWHHEGLPVAESNESRLET-DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV 1684
Query: 311 RAPPQFVVRPRDQIVAQ--GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRC 368
+ PPQ +V V G+ + PC+ G+P P + W + G +P + +
Sbjct: 1685 QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------RPAEELAGV 1736
Query: 369 SVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQ 427
V+ G L I +++ +G + CQA AG+ A A++EV+ + P +L+ P Q
Sbjct: 1737 QVASQGTTLHIDHVELDHSGLFACQATNEAGT--AGAEVEVS--VHGEWAPGVLEVPIGQ 1792
Query: 428 TLAVDGTALLKCKATGDPLPVISW-------LKEGFTFPGR---DPR---ATIQEQGTLQ 474
A DP W L EG+ PG +P LQ
Sbjct: 1793 -YHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQ 1851
Query: 475 IKNLRISDTGTYTCVATSSSGETSWSAVLDV----------TESGATISKNYDLSDLPGP 524
I+ + + D G YTC AT+ +GE+ L V + + L L
Sbjct: 1852 IEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASG 1911
Query: 525 PSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRG 584
P V+ + SW G ++ IE S + S++ VA++V + G
Sbjct: 1912 VPPPDVSWFKGHQPVSSWM-GVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG 1970
Query: 585 LRPNTIYLFMVRAINPQGLSDPSPMSDPVR 614
LR N R P L P ++ PVR
Sbjct: 1971 LRVNV----PPRITLPPSLPGPVLVNTPVR 1996
Score = 139 bits (349), Expect = 2e-32
Identities = 119/421 (28%), Positives = 173/421 (41%), Gaps = 46/421 (10%)
Query: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEP 163
DEG Y C A N GE+ R +L+V L+ + P + V LEC G P P
Sbjct: 1859 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECL-ASGVPPP 1915
Query: 164 TIYWKKDKVRIDD-KEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE-------RDSD 215
+ W K + +S+ G L I + SDAG Y CV +N+ G R +
Sbjct: 1916 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 1975
Query: 216 PAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL-PRGRYDIK- 273
P +T+ P L P VL V C G P PT+ W KD + P G ++
Sbjct: 1976 PPRITL---PPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 2028
Query: 274 --DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 331
L + ++D G Y C+A + VG+ L V PP + + V +V
Sbjct: 2029 FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESV 2088
Query: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS---DAGY 388
C++ P P + W K+G +P +P R V + D + + R+ DAG+
Sbjct: 2089 ALECQSHAMPPPVLSWWKDG--------RPLEP--RPGVHLSADKALLQVDRADVWDAGH 2138
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
Y C+AL AG L V P L+ T+ L C+ G P P
Sbjct: 2139 YTCEALNQAGHSEKHYNLNVWVA-----PVFPLRESHTLTVREGHPTSLSCECRGVPFPK 2193
Query: 449 ISWLKEGFTFPGRDPRATIQEQGT----LQIKNLRISDTGTYTCVATSSSGETSWSAVLD 504
ISW K+G PG A +Q L + +++ GTYTC ++ G +S L+
Sbjct: 2194 ISWRKDGQPLPGEG--AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLE 2251
Query: 505 V 505
V
Sbjct: 2252 V 2252
Score = 137 bits (346), Expect = 5e-32
Identities = 118/418 (28%), Positives = 174/418 (41%), Gaps = 32/418 (7%)
Query: 99 RRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT-DVVVAAGEPAILECQPP 157
R SK +EG+Y C A + A + A ++ + + P +V V+ GE A+L C+
Sbjct: 485 RASKAEEGTYECTA---VSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCR-V 540
Query: 158 RGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDP 216
G + W +D + R++ + L IS +D G Y CV +N G +
Sbjct: 541 LGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS- 599
Query: 217 AELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-GRYDIKDD 275
L V E P +Q + V+ C G P P + W ++ L R +
Sbjct: 600 VWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQ 659
Query: 276 YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPC 335
TL I+ D G Y C A N VG + + TL PP +VA G C
Sbjct: 660 GTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 719
Query: 336 ETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALT 395
E G P P V W + G + +L P S +G L I Q DAG Y C+A+
Sbjct: 720 EASGVPPPRVIWYRGGLEMILAPEG----------SSSGKLRIPAAQERDAGTYTCRAVN 769
Query: 396 VAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG 455
G A+ QL V P + + P + T+ + +ALL C+ATG P P ++W + G
Sbjct: 770 ELGDASAEIQLAVGHA------PQLTELPRDVTVELGRSALLACRATGRPPPTVTW-RRG 822
Query: 456 FTFP-------GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVT 506
P GR R+ + G L +++ D Y C A + G+ A L VT
Sbjct: 823 DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 880
Score = 135 bits (340), Expect = 3e-31
Identities = 139/540 (25%), Positives = 206/540 (38%), Gaps = 104/540 (19%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKA-EGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88
PP+I V V +G+P +L C GRP P W KDG + P S + G
Sbjct: 884 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP-----PGSRHSIRADG 938
Query: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL-LRDDFRQNPTDVVVAAG 147
SL R + + G Y CVA N G S++ +E+ + + T + G
Sbjct: 939 SLHLDRAL-----QEHAGRYSCVATNTAG---SQHRDVELVVQVPPRIHPTATHHITNEG 990
Query: 148 EPAILECQPPRGHPEPTIYWKKDK------------------------------------ 171
PA L C G P PTI W K+
Sbjct: 991 VPASLPCVAS-GVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT 1049
Query: 172 --VRIDDKEERISIR----------------GGKLMISNTRKSDAGMYTCVGTNMVGERD 213
V +E R+S+ G L ++ + D+G Y C +N G
Sbjct: 1050 NTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA- 1108
Query: 214 SDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK 273
S L V P P VL EA++ C +G+P+P + W KD L +GR
Sbjct: 1109 SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVL-QGR---G 1164
Query: 274 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQ--GRTV 331
++ ++D G Y C A N G L V PP + ++ + G
Sbjct: 1165 PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENA 1224
Query: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYIC 391
+ PC +G P+P V W+K S ++P +V G L + ++ +D+G Y C
Sbjct: 1225 SLPCPARGTPKPQVTWRKGPS------SEPLHGQPGVAVLEEGSLFLASVSPADSGDYEC 1278
Query: 392 QALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL-LKCKATGDPLPVIS 450
QA GS +A+L V PP I G + G +L L+C A G P+P I
Sbjct: 1279 QATNEVGSTSRRAKLVVY-----VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIV 1333
Query: 451 WLKE--------GFTFPGRD-------PRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
WLK+ G+ G D + E +L ++ D+G Y+C A + +G
Sbjct: 1334 WLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 1393
Score = 125 bits (314), Expect = 3e-28
Identities = 100/353 (28%), Positives = 144/353 (40%), Gaps = 21/353 (5%)
Query: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTN 207
+P ++ C P + ++ + R+ ++ I K++ G Y C +
Sbjct: 442 QPLLVSCSVHSALPF-RLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 500
Query: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP- 266
G + A++ V + P L N V E C+V G+ + W +D LP
Sbjct: 501 RAGTGRAK-AQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPA 559
Query: 267 -RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIV 325
GR D +L I + TD G Y C+A N G AS L VR PQ + Q
Sbjct: 560 STGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHF 619
Query: 326 AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSD 385
+QG V C G P P + W +E +Q Q +SR V G L I + D
Sbjct: 620 SQGVEVKVSCSASGYPTPHISWSRE--------SQALQEDSRIHVDAQGTLIIQGVAPED 671
Query: 386 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 445
AG Y CQA G+ L TD PP + A +AV A+L C+A+G P
Sbjct: 672 AGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVNAVVLVAVGEEAVLVCEASGVP 725
Query: 446 LPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETS 498
P + W + G P + G L+I + D GTYTC A + G+ S
Sbjct: 726 PPRVIWYRGGLEMI-LAPEGS--SSGKLRIPAAQERDAGTYTCRAVNELGDAS 775
Score = 112 bits (280), Expect = 2e-24
Identities = 88/282 (31%), Positives = 120/282 (42%), Gaps = 19/282 (6%)
Query: 37 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIV 96
P D + G+ L C A G PTP I W T D P + + G R
Sbjct: 4135 PGDRSLRLGDRLWLRCAARGSPTPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA 4186
Query: 97 HGRRSKPDEGSYVCVARNYLG--EAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
R D G+YVC A N +G +AVS E +L+ + +V G L+C
Sbjct: 4187 VSRE---DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSY---LVEPVGGSIQLDC 4240
Query: 155 QPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
RG P P I+W KD + + R ++ G L I T + DAG Y C+ N +G
Sbjct: 4241 VV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 4299
Query: 215 DPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIK 273
L + P F P + V + V RCQ G+P PT+ W + L R
Sbjct: 4300 -VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL 4358
Query: 274 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
D +L ++ + D GTY C+A N +G A A L VR PQ
Sbjct: 4359 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 4400
Score = 80.9 bits (198), Expect = 8e-15
Identities = 75/292 (25%), Positives = 116/292 (39%), Gaps = 29/292 (9%)
Query: 227 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIKDDYTLRIKKTMS 285
+L +P+ A+ FR Q+ ++ +A L R + + + I +
Sbjct: 439 YLHQPLLVSCSVHSALPFRLQL----------RRGEARLGEERHFQESGNSSWEILRASK 488
Query: 286 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 345
+EGTY C A +R G A A + V PP +V + V+ G T C G +
Sbjct: 489 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL 548
Query: 346 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT--ITNIQRSDAGYYICQALTVAGSILAK 403
W ++ P S V+ DL+ I+ I +D G Y C A G A
Sbjct: 549 TWVRDWR---------VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 599
Query: 404 AQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP 463
L V R P + ++Q + + C A+G P P ISW +E D
Sbjct: 600 VWLLV------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ-EDS 652
Query: 464 RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKN 515
R + QGTL I+ + D G Y+C AT+ G + L T+ + + N
Sbjct: 653 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVN 704
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 205 bits (521), Expect = 3e-52
Identities = 154/473 (32%), Positives = 213/473 (45%), Gaps = 38/473 (8%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P I P V VS + L C+A+G P P + W KD RV D PR +LP GSL
Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKD--RVPLDPRSPRFE--ILPEGSL 2446
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-FRQNPTDVVVAAGEP 149
++ D G Y+C+A N G S ++ +L +P+++ + A P
Sbjct: 2447 RIQPVL-----AQDAGHYLCLASNSAG---SDRQGRDLRVLEPPAIAPSPSNLTLTAHTP 2498
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR---GGKLMISNTRKSDAGMYTCVGT 206
A+L C+ G P+P + W KD ++D + ++ + R L+++ D+ + CV +
Sbjct: 2499 ALLPCEAS-GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVS 2557
Query: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL- 265
N VGE ++TV PT + V V C G P PTV W K A L
Sbjct: 2558 NEVGEAHR-LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 2616
Query: 266 PRGR-YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
RG Y + L I + + G Y C A N G LTV+A P VV+P +
Sbjct: 2617 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSV 2674
Query: 325 V--AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQ 382
V V PCE G P+P + WQKEG V P G L I +
Sbjct: 2675 VRAVAEEEVLLPCEASGIPRPTITWQKEGLN--------VATGVSTQVLPGGQLRIAHAS 2726
Query: 383 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKAT 442
DAG Y+C A AGS + K +L V + PP+I G + + A L CKA
Sbjct: 2727 PEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPCKAR 2780
Query: 443 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
G P P I+W K+G G + + TIQ G L +KNL D GTYTC A ++ G
Sbjct: 2781 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVG 2833
Score = 202 bits (514), Expect = 2e-51
Identities = 147/477 (30%), Positives = 214/477 (44%), Gaps = 31/477 (6%)
Query: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
P + PS V E L C+A G P PTI W K+G V T +LP G L
Sbjct: 2666 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 2720
Query: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPA 150
RI H S D G+Y+C+A+N G A+ + V + D+ G A
Sbjct: 2721 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 2773
Query: 151 ILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTNMV 209
L C+ RG PEP I W KD + E + +I+ G+L++ N DAG YTC N V
Sbjct: 2774 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2832
Query: 210 GERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR 269
G R LT+ P F P ++ + + + RC +G P P + W +D + G
Sbjct: 2833 G-RARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2891
Query: 270 YDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQ-G 328
+ TL+ D GTY+C AENRVG+ +A + + V+ P +V G
Sbjct: 2892 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 2951
Query: 329 RTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 388
++ C +G+P P + W K+G P + + G LTI +R DAG
Sbjct: 2952 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIRRTERDDAGR 3003
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
Y C A G +AK + +L + P+ P + T+ L+C+ATG+P P
Sbjct: 3004 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 3057
Query: 449 ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
I WL+ G T+ + G+L ++N+ D GTY CVA + G + A L V
Sbjct: 3058 IEWLQAGQPLRASRRLRTLPD-GSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3113
Score = 182 bits (461), Expect = 3e-45
Identities = 134/486 (27%), Positives = 203/486 (41%), Gaps = 38/486 (7%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I PS++ ++ P L C+A G P P + W+KDG++++ + LLPS +
Sbjct: 2481 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNA 2538
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL-LRDDFRQNPTDVVVAAGE 148
L D + CV N +GEA + +V + + + TD V
Sbjct: 2539 LLLTA-----PGPQDSAQFECVVSNEVGEA---HRLYQVTVHVPPTIADDQTDFTVTMMA 2590
Query: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTN 207
P +L C G P PT+ W K ++ + + G L I AG YTC N
Sbjct: 2591 PVVLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARN 2649
Query: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR 267
G LTV P P + EE V C+ G P+PT+ W+K+ ++
Sbjct: 2650 SAGVAHKH-VFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT 2708
Query: 268 G-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA 326
G + LRI D G Y+CIA+N G L V+ PP D
Sbjct: 2709 GVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT 2768
Query: 327 QGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQ-PNSRCSVSPTGDLTITNIQRSD 385
+G PC+ +G+P+P + W K+G QP + ++ P+G+L + N++ D
Sbjct: 2769 EGSHAFLPCKARGSPEPNITWDKDG--------QPVSGAEGKFTIQPSGELLVKNLEGQD 2820
Query: 386 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 445
AG Y C A G + L + + P+ P +++L + L+C A G P
Sbjct: 2821 AGTYTCTAENAVGRARRRVHLTILVL------PVFTTLPGDRSLRLGDRLWLRCAARGSP 2874
Query: 446 LPVISWLKEGFTFPGRDPRATIQEQ---GTLQIKNLRISDTGTYTCVATSSSGETSWSAV 502
P I W T R + EQ TLQ + D+GTY C A + G T +
Sbjct: 2875 TPRIGW-----TVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSF 2929
Query: 503 LDVTES 508
+ V E+
Sbjct: 2930 VHVKEA 2935
Score = 179 bits (455), Expect = 1e-44
Identities = 150/505 (29%), Positives = 223/505 (44%), Gaps = 46/505 (9%)
Query: 37 PSD-VIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95
P D V+V G+ L+C+ + P PT+ WYKDG+ + L G R+
Sbjct: 1756 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQ----RL 1806
Query: 96 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQ 155
D+G Y C N GEAV R +L V + V AG P +L C
Sbjct: 1807 EIQEAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1865
Query: 156 PPRGHPEPTIYWKKDKVRIDDKE-ERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
G P PT+ W KD++ ++ + RGG+L +S + + AG YTCV N E
Sbjct: 1866 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 1924
Query: 215 DPAELTVFERPTFLRRPI--NQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL-----PR 267
D + V P + VLE + V C+ G P P V W KD + L P
Sbjct: 1925 D-FVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPH 1983
Query: 268 GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP---QFVVRPRDQI 324
R+ + D +L +K ++D G Y C+A N G+ T+ V PP Q +
Sbjct: 1984 LRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLV 2042
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG-DLTITNIQR 383
G VT C +G+P V W K+G P + R + +G L I+ +Q
Sbjct: 2043 SRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISKVQL 2094
Query: 384 SDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL-LKCKAT 442
+DAG + C A + AG L+V PP + N + V G+ + L C+A
Sbjct: 2095 ADAGIFTCVAASPAGVADRNFTLQV-----QVPPVLEPVEFQNDVVVVRGSLVELPCEAR 2149
Query: 443 GDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAV 502
G PLP++SW+K+G + ++++ +LQ++ + D+GTY+CVA S +GE
Sbjct: 2150 GVPLPLVSWMKDGEPLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2205
Query: 503 LDVTESG--ATISKNYDLSDLPGPP 525
L V E + +LS PG P
Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAP 2230
Score = 177 bits (450), Expect = 5e-44
Identities = 165/568 (29%), Positives = 243/568 (42%), Gaps = 60/568 (10%)
Query: 30 PPRIVEHP--SDVIVSK-GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
PP I + S +VS+ GE T+ C G P + W KDG + P S R LL
Sbjct: 2028 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 2080
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVAL---LRDDFRQNPTDVV 143
GS LRI + D G + CVA + G A RN +L+V + L QN DVV
Sbjct: 2081 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 2135
Query: 144 VAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTC 203
V G L C+ RG P P + W KD + + +G L + D+G Y+C
Sbjct: 2136 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 2191
Query: 204 VGTNMVGERDSDPAELTVFERPTF--LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKD 261
V + GE +LTV E P +P + +E C QG PQP + W KD
Sbjct: 2192 VAVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 2250
Query: 262 DADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPR 321
L R + + LR++ D G Y C+AE+ G +E S + V+APP +V PR
Sbjct: 2251 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 2304
Query: 322 DQIVAQGRT---VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LT 377
G + C + P P + W ++G Q ++ G L
Sbjct: 2305 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIV--------LQEDAHTQFPERGRFLQ 2356
Query: 378 ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 437
+ + +D+G Y C A AGS ++E+ V P I GP ++V+ TALL
Sbjct: 2357 LQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALL 2410
Query: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
C+A G P P++SW K+ R PR I +G+L+I+ + D G Y C+A++S+G
Sbjct: 2411 PCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSD 2470
Query: 498 SWSAVLDVTESGATISKNYDLS-----------DLPGPPSKPQVTDVTKNSVTLSWQPGT 546
L V E A +L+ + G P V + Q G
Sbjct: 2471 RQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGA 2530
Query: 547 PGTLPASAYIIEAFSQSVSNSWQTVANH 574
LP++A ++ A S ++ V ++
Sbjct: 2531 YRLLPSNALLLTAPGPQDSAQFECVVSN 2558
Score = 170 bits (431), Expect = 8e-42
Identities = 134/485 (27%), Positives = 201/485 (41%), Gaps = 36/485 (7%)
Query: 30 PPRIVE--HPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I + P+++ ++ G P L C A+G P P I W+KDG+ + +++ R+ R+L
Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 2270
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR-QNPTDVVVAA 146
D G Y C+A + G A+ ++ + V + + P VV A
Sbjct: 2271 ----------------DAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLA 2313
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRI-DDKEERISIRGGKLMISNTRKSDAGMYTCVG 205
+LEC P P I W +D + + +D + RG L + +D+G Y+C
Sbjct: 2314 PGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA 2372
Query: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL 265
N G S + + PT P V + CQ G P P V W+KD L
Sbjct: 2373 RNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPL 2431
Query: 266 -PRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ 323
PR R++I + +LRI+ ++ D G Y+C+A N G L V PP P +
Sbjct: 2432 DPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 2491
Query: 324 IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQR 383
+ PCE G+P+P V W K+G Q L F Q + P+ L +T
Sbjct: 2492 TLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAPGP 2546
Query: 384 SDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATG 443
D+ + C G Q+ V PP I + T+ + +L C +TG
Sbjct: 2547 QDSAQFECVVSNEVGEAHRLYQVTV------HVPPTIADDQTDFTVTMMAPVVLTCHSTG 2600
Query: 444 DPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVL 503
P P +SW K G R + G L+I G YTC A +S+G L
Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2660
Query: 504 DVTES 508
V S
Sbjct: 2661 TVQAS 2665
Score = 170 bits (430), Expect = 1e-41
Identities = 136/484 (28%), Positives = 206/484 (42%), Gaps = 37/484 (7%)
Query: 30 PPRIV---EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
PP+I E P+ V V + TL C A G+P PT+ W +DG+ V + L
Sbjct: 973 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 1027
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ-NP-TDVVV 144
G + R G Y CVA N G A R L V + + +P T++
Sbjct: 1028 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLTNITA 1082
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGG-KLMISNTRKSDAGMYTC 203
A P L C+ G P P I W + + + E+ + GG L ++ T++ D+G+Y+C
Sbjct: 1083 ALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSC 1141
Query: 204 VGTNMVGERDSDPAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKD 261
+ +N GE + + V P+ + +V VL+ + C V G PQP + W KD
Sbjct: 1142 LASNEAGEARRN-FSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKD 1200
Query: 262 DADLPRG--RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR 319
L RG + D L++ + + G Y CIA N VG+ L+V P +
Sbjct: 1201 GRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGG 1260
Query: 320 PRDQI-----VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP-T 373
D V ++ CE P P + W K+G+ P + + + P T
Sbjct: 1261 AEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLPGT 1312
Query: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT-DVLTDRPPPIILQGPANQTLAVD 432
L I N Q+ DAG Y C G + +EV + P+ G V+
Sbjct: 1313 HGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372
Query: 433 GTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATS 492
T L+C++ P P I W K+G + E LQI+ ++SD+G Y CVAT+
Sbjct: 1373 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432
Query: 493 SSGE 496
+GE
Sbjct: 1433 VAGE 1436
Score = 166 bits (421), Expect = 1e-40
Identities = 146/486 (30%), Positives = 204/486 (41%), Gaps = 34/486 (6%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I P + V + TL C A G P P + W+K + V S + S
Sbjct: 603 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 655
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
LRI + S D GSY CVA N G R L V + V P
Sbjct: 656 GRVLRIEQAQLS--DAGSYRCVASNVAGSTELR-YGLRVNVPPRITLPPSLPGPVLVNTP 712
Query: 150 AILECQPPRGHPEPTIYWKKDKVRIDDKEE---RISIRGGKLMISNTRKSDAGMYTCVGT 206
L C G P PT+ W KD + ++ G L +++ R SD+G Y+CV
Sbjct: 713 VRLTCN-ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 771
Query: 207 NMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL- 265
+ VGE D L V P+ L +N V+ E+V CQ P P + W KD L
Sbjct: 772 SAVGE-DRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 830
Query: 266 PR-GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
PR G + D L++ + D G Y C A N+ G E L V P F +R +
Sbjct: 831 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 890
Query: 325 -VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT-ITNIQ 382
V +G CE +G P P + W+K+G P + VS G L + Q
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 944
Query: 383 RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPII--LQGPANQTLAVDGTALLKCK 440
+ G Y C+ V G+ QLEV PP I + P ++ DG A L+C
Sbjct: 945 LAQEGTYTCECSNVVGNSSQDLQLEV-----HVPPQIAGPREPPTQVSVVQDGVATLECN 999
Query: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQG-TLQIKNLRISDTGTYTCVATSSSGETSW 499
ATG P P ++W ++G G + +Q QG +L ++ + + TG Y+CVA + +G
Sbjct: 1000 ATGKPPPTVTWERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAER 1058
Query: 500 SAVLDV 505
L V
Sbjct: 1059 KFELSV 1064
Score = 164 bits (416), Expect = 4e-40
Identities = 147/529 (27%), Positives = 220/529 (41%), Gaps = 47/529 (8%)
Query: 26 QEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL 85
Q PP I+ +V V E L C++ P P + W+KDG +E PR L
Sbjct: 784 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 838
Query: 86 PSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR-NASLEVALLRDDFRQNPTDVVV 144
+L + R D G Y C A N G + N ++ VA + R++ T + V
Sbjct: 839 ADKALLQV----DRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-LRESHT-LTV 892
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE---ERISIRGGKLMISNTRKSDAGMY 201
G P L C+ RG P P I W+KD + + + +S G L + + + G Y
Sbjct: 893 REGHPTRLSCEC-RGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTY 951
Query: 202 TCVGTNMVGERDSDPAELTVFERPTFL--RRPINQV-VLEEEAVEFRCQVQGDPQPTVRW 258
TC +N+VG D +L V P R P QV V+++ C G P PTV W
Sbjct: 952 TCECSNVVGNSSQD-LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTW 1010
Query: 259 KKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF 316
++D + G +L +++ + G Y C+AEN G+ E L+V PP+
Sbjct: 1011 ERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1070
Query: 317 V--VRPRDQIVAQGRT-VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373
+ + P I A + +T CE G P PA+ W + +P P +
Sbjct: 1071 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRG--------EEPVSPGEDTYLLAG 1122
Query: 374 G-DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 432
G L +T Q D+G Y C A AG +EV PP I + +D
Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV-----PPSIENEDLEEVIKVLD 1177
Query: 433 G-TALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVAT 491
G TA L C TG P P ++W K+G D + LQ+ +S G Y+C+A
Sbjct: 1178 GQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 1237
Query: 492 SSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTL 540
++ GE + L V + + D +D +VT N ++L
Sbjct: 1238 NAVGEKTKHFQLSVLLAPTILGGAEDSAD-------EEVTVTVNNPISL 1279
Score = 158 bits (399), Expect = 4e-38
Identities = 138/491 (28%), Positives = 200/491 (40%), Gaps = 46/491 (9%)
Query: 30 PPRIVEHPSDVIVS--KGEPTTLNCKAEGRPTPTIEWYKDGERV-----------ETDKD 76
PP I E VS G+ TL C A G P P I W KD + V +
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75
Query: 77 DPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFR 136
HR+L SL F RI G D G Y C A N G A R+ L V
Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTA-QRDFHLLVLTPPSVLG 129
Query: 137 QNPTDVVVA-AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR--GGKLMISNT 193
V+ AG L+C G P P + W KD+ + + ++ G L I+ +
Sbjct: 130 AGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGS 188
Query: 194 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFL--RRPINQVVLEEEAVEFRCQVQGD 251
D G Y CV + G++ D +L V PT V+E+ V+ C+ +G
Sbjct: 189 HVGDEGRYQCVAFSPAGQQARD-FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGV 247
Query: 252 PQPTVRWKKDDADLPRGRYDI--KDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 309
P P + W KD A LP + + L++ + S+D G Y C A N VG E + L
Sbjct: 248 PTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLD 307
Query: 310 VRAPPQFVV---RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS 366
V PP RP GR V C +G+P P + W EG P ++
Sbjct: 308 VYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL--------PVAESN 359
Query: 367 RCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 425
+ G L + + + +G Y C A + AG + + +EV PP +++
Sbjct: 360 ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-----QVPPQLLVAEGL 414
Query: 426 NQTLAVDGTAL-LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTG 484
Q + G L L C+A+G P+P I WL+ G + TL I ++ + +G
Sbjct: 415 GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG 474
Query: 485 TYTCVATSSSG 495
+ C AT+ +G
Sbjct: 475 LFACQATNEAG 485
Score = 158 bits (399), Expect = 4e-38
Identities = 131/477 (27%), Positives = 195/477 (40%), Gaps = 39/477 (8%)
Query: 42 VSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRS 101
+ + P L C P P + WY++ + + + +L G + + +V +
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVS-----VLQGGRVLQIPLVRAENA 1534
Query: 102 KPDEGSYVCVARNYLGEAVSRNASLEVA--LLRDDFRQNPTDVVVAAGEPAILECQPPRG 159
G Y C A N +GE L + ++ D + +V V A L+C P G
Sbjct: 1535 ----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALG 1589
Query: 160 HPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTCVGTNMVGERDSDPAE 218
+P PTI W ++ + + G+ L +S +DA Y CV N G +
Sbjct: 1590 NPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEK-LFT 1648
Query: 219 LTVFERPTFLRRPINQVV-LEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR--YDIKDD 275
L V P + QV + +V C V P P V W KD L G + +
Sbjct: 1649 LRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGT 1708
Query: 276 YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQ----IVAQGRTV 331
+TL++ + +D G Y C A N G+ + L+V PP F PR +V G
Sbjct: 1709 HTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKA 1768
Query: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYI 390
CET P+P V W K+G QP R G L I Q SD G Y
Sbjct: 1769 VLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKGLYS 1820
Query: 391 CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLA-VDGTAL-LKCKATGDPLPV 448
C+ VAG + T LT + PP + P +T++ V G+ L L C +G P P
Sbjct: 1821 CKVSNVAGEAVR------TFTLTVQVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPT 1873
Query: 449 ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
++WLK+ + G LQ+ L+ + GTYTCVA ++ E V+ V
Sbjct: 1874 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAV 1930
Score = 154 bits (389), Expect = 6e-37
Identities = 120/384 (31%), Positives = 174/384 (45%), Gaps = 30/384 (7%)
Query: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
PP I D+ ++G L CKA G P P I W KDG+ V + PSG
Sbjct: 2755 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 2810
Query: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
L ++ + G+ D G+Y C A N +G A R L + +L F P D + G+
Sbjct: 2811 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 2863
Query: 150 AILECQPPRGHPEPTIYWK-KDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNM 208
L C RG P P I W D+ + E+ G L + + D+G Y C N
Sbjct: 2864 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQDG--GSTLQRAAVSREDSGTYVCWAENR 2920
Query: 209 VGERDSDPAELTVFERPTFLRRPINQVVLEEE-AVEFRCQVQGDPQPTVRWKKDDADLPR 267
VG R + + V E P + +V +++ C V+GDP P + W KD L R
Sbjct: 2921 VG-RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL-R 2978
Query: 268 G---RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQI 324
G R+ +++ +L I++T D G Y C+AEN +G + L +++ P F V P+D
Sbjct: 2979 GSHLRHQLQNG-SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3037
Query: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS 384
V G V C+ G P P + W + G QP + + R P G L + N++
Sbjct: 3038 VRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVETG 3089
Query: 385 DAGYYICQALTVAGSILAKAQLEV 408
DAG Y C A + GS A+A L V
Sbjct: 3090 DAGTYDCVAHNLLGSATARAFLVV 3113
Score = 153 bits (387), Expect = 1e-36
Identities = 138/508 (27%), Positives = 210/508 (41%), Gaps = 69/508 (13%)
Query: 30 PPRIVEHPSDVIVS--KGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP I + ++ G+ L C G P P + W+KDG + +H + P
Sbjct: 1161 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 1215
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR---NASLEVALLRDDFRQNPTDVVV 144
G L L+++ S G Y C+A N +GE + L +L +V V
Sbjct: 1216 GVL--LQVLQANLSSA--GHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 1271
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKSDAGMYTC 203
P L C+ P P I W KD + + G L I N +K DAG YTC
Sbjct: 1272 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1330
Query: 204 VGTNMVGERDSDPAELTVFERPTFLRR-PINQVVLEE------EAVEFRCQVQGDPQPTV 256
V TN +GE + + V P+ + P+ +V ++E + C+ P PT+
Sbjct: 1331 VVTNELGEAVKN-YHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTI 1389
Query: 257 RWKKDDADL-PRGRYDIKDD-YTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
RW KD + P R + + L+I+ T +D G Y+C+A N G+ + + ++ PP
Sbjct: 1390 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1449
Query: 315 QFV----------VRPRDQIVAQGRT----------VTFPCETKGNPQPAVFWQKEGSQN 354
F + R++ G T C+T P P + W +E
Sbjct: 1450 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRE---- 1505
Query: 355 LLFPNQPQQPNSRCSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLT 413
+QP SV G L I ++ +AG Y C+A G +L V
Sbjct: 1506 ----DQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 1558
Query: 414 DRPPPIILQGPANQ-----TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQ 468
PP+IL G + T+ T L+C A G+P+P ISWL+ G F PR +
Sbjct: 1559 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPF-SPSPRLQVL 1613
Query: 469 EQG-TLQIKNLRISDTGTYTCVATSSSG 495
E G LQ+ ++D +Y CVA + +G
Sbjct: 1614 EDGQVLQVSTAEVADAASYMCVAENQAG 1641
Score = 147 bits (371), Expect = 7e-35
Identities = 137/495 (27%), Positives = 203/495 (41%), Gaps = 58/495 (11%)
Query: 30 PPRIV--EHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPS 87
PP+++ E V G+P L C+A G P PTI+W ++G E + +
Sbjct: 405 PPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQVASQ 459
Query: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA-- 145
G+ + V S G + C A N G A A +EV++ ++ +V +
Sbjct: 460 GTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSV-HGEWAPGVLEVPIGQY 511
Query: 146 -------AGEPAILECQPP--RG---HPEPTIY--WKKDKVRIDDKEERISIRGG---KL 188
+ PA C PP RG HP+P + W + + I + L
Sbjct: 512 HWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPG-SLWGEPTGIPVAYSLPPPL 568
Query: 189 MISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQV 248
I D G+YTC TN+ GE + A L V P P+N+ VLE +V C
Sbjct: 569 QIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECLA 627
Query: 249 QGDPQPTVRWKKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA 306
G P P V W K + G D LRI++ +D G+Y C+A N G E
Sbjct: 628 SGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRY 687
Query: 307 TLTVRAPPQFVVRPR-DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPN 365
L V PP+ + P V V C G P P + W K+G+ P P
Sbjct: 688 GLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN--------PVSPA 739
Query: 366 SR--CSVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422
V P G LT+ + + SD+G Y C A++ G L+V PP IL
Sbjct: 740 GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMPPSILG 793
Query: 423 GPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISD 482
N ++ + + L+C++ P PV+SW K+G R ++ LQ+ + D
Sbjct: 794 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWD 853
Query: 483 TGTYTCVATSSSGET 497
G YTC A + +G +
Sbjct: 854 AGHYTCEALNQAGHS 868
Score = 145 bits (365), Expect = 3e-34
Identities = 148/507 (29%), Positives = 208/507 (41%), Gaps = 68/507 (13%)
Query: 45 GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPD 104
G P L C A G P+PT+ W+ +G V + L GS+ L +
Sbjct: 329 GRPVALECVARGHPSPTLSWHHEGLPVAESNES-----RLETDGSVLRLE----SPGEAS 379
Query: 105 EGSYVCVARNYLGEAVSRNASLEVA-----LLRDDFRQNPTDVVVAAGEPAILECQPPRG 159
G Y CVA + GEAV + S+EV L+ + Q V G+P L CQ G
Sbjct: 380 SGLYSCVASSPAGEAVLQY-SVEVQVPPQLLVAEGLGQ----VTTIVGQPLELPCQAS-G 433
Query: 160 HPEPTIYWKKDKVRIDDKEE-RISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE 218
P PTI W ++ ++ +++ +G L I + +G++ C TN G ++ E
Sbjct: 434 SPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE-VE 492
Query: 219 LTVFER--PTFLRRPINQVVLEEE---AVEFRCQ---------------VQGDPQPTVRW 258
++V P L PI Q E + C V+G P W
Sbjct: 493 VSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLW 552
Query: 259 KKDDADLPRG---RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
+ P G Y + L+I+K DEG Y C A N G+ + L V PP
Sbjct: 553 GE-----PTGIPVAYSLPPP--LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN 605
Query: 316 FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGD 375
P ++ V + +VT C G P P V W K +QP +VS G
Sbjct: 606 IEPGPVNKAVLENASVTLECLASGVPPPDVSWFK--------GHQPVSSWMGVTVSVDGR 657
Query: 376 -LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 434
L I Q SDAG Y C A VAGS + L V + PP I L + V+
Sbjct: 658 VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV-----NVPPRITLPPSLPGPVLVNTP 712
Query: 435 ALLKCKATGDPLPVISWLKEGF-TFPGRDPRATIQEQG-TLQIKNLRISDTGTYTCVATS 492
L C ATG P P + WLK+G P P + G L + + R SD+G Y+CVA S
Sbjct: 713 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVS 772
Query: 493 SSGETSWSAVLDVTESGATISKNYDLS 519
+ GE VL V + + + ++S
Sbjct: 773 AVGEDRQDVVLQVHMPPSILGEELNVS 799
Score = 143 bits (361), Expect = 1e-33
Identities = 164/630 (26%), Positives = 248/630 (39%), Gaps = 70/630 (11%)
Query: 26 QEDFPPRIVEHPS--------DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDD 77
Q DF ++ PS +V+ G L C G PTP +EW KD + V
Sbjct: 114 QRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGP- 172
Query: 78 PRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQ 137
H + G + LRI DEG Y CVA + G+ +R+ L V +
Sbjct: 173 ---HLQVQEDGQV--LRITGSHVG--DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGS 224
Query: 138 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK-LMISNTRKS 196
N T V + + RG P P I W KD + + + RGG+ L + + S
Sbjct: 225 NETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSS 284
Query: 197 DAGMYTCVGTNMVGERDSDPAELTVFERPTFLR---RPINQVVLEEEAVEFRCQVQGDPQ 253
DAG+YTC +N VG + L V+ PT RP + V C +G P
Sbjct: 285 DAGVYTCKASNAVGAAEK-ATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 343
Query: 254 PTVRWKKDD---ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
PT+ W + A+ R + D LR++ G Y C+A + G+ ++ V
Sbjct: 344 PTLSWHHEGLPVAESNESRLET-DGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV 402
Query: 311 RAPPQFVVRPRDQIVAQ--GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRC 368
+ PPQ +V V G+ + PC+ G+P P + W + G +P + +
Sbjct: 403 QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--------RPAEELAGV 454
Query: 369 SVSPTGD-LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQ 427
V+ G L I +++ +G + CQA AG+ A A++EV+ + P +L+ P Q
Sbjct: 455 QVASQGTTLHIDHVELDHSGLFACQATNEAGT--AGAEVEVS--VHGEWAPGVLEVPIGQ 510
Query: 428 TLAVDGTALLKCKATGDPLPVISW-------LKEGFTFPGR---DPR---ATIQEQGTLQ 474
A DP W L EG+ PG +P LQ
Sbjct: 511 -YHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQ 569
Query: 475 IKNLRISDTGTYTCVATSSSGETSWSAVLDV----------TESGATISKNYDLSDLPGP 524
I+ + + D G YTC AT+ +GE+ L V + + L L
Sbjct: 570 IEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASG 629
Query: 525 PSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRG 584
P V+ + SW G ++ IE S + S++ VA++V + G
Sbjct: 630 VPPPDVSWFKGHQPVSSWM-GVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG 688
Query: 585 LRPNTIYLFMVRAINPQGLSDPSPMSDPVR 614
LR N R P L P ++ PVR
Sbjct: 689 LRVNV----PPRITLPPSLPGPVLVNTPVR 714
Score = 139 bits (349), Expect = 2e-32
Identities = 119/421 (28%), Positives = 173/421 (41%), Gaps = 46/421 (10%)
Query: 104 DEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEP 163
DEG Y C A N GE+ R +L+V L+ + P + V LEC G P P
Sbjct: 577 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECL-ASGVPPP 633
Query: 164 TIYWKKDKVRIDD-KEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGE-------RDSD 215
+ W K + +S+ G L I + SDAG Y CV +N+ G R +
Sbjct: 634 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV 693
Query: 216 PAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADL-PRGRYDIK- 273
P +T+ P L P VL V C G P PT+ W KD + P G ++
Sbjct: 694 PPRITL---PPSLPGP----VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQV 746
Query: 274 --DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 331
L + ++D G Y C+A + VG+ L V PP + + V +V
Sbjct: 747 FPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESV 806
Query: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS---DAGY 388
C++ P P + W K+G +P +P R V + D + + R+ DAG+
Sbjct: 807 ALECQSHAMPPPVLSWWKDG--------RPLEP--RPGVHLSADKALLQVDRADVWDAGH 856
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPV 448
Y C+AL AG L V P L+ T+ L C+ G P P
Sbjct: 857 YTCEALNQAGHSEKHYNLNVWVA-----PVFPLRESHTLTVREGHPTRLSCECRGVPFPK 911
Query: 449 ISWLKEGFTFPGRDPRATIQEQGT----LQIKNLRISDTGTYTCVATSSSGETSWSAVLD 504
ISW K+G PG A +Q L + +++ GTYTC ++ G +S L+
Sbjct: 912 ISWRKDGQPLPGEG--AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLE 969
Query: 505 V 505
V
Sbjct: 970 V 970
Score = 122 bits (306), Expect = 2e-27
Identities = 114/406 (28%), Positives = 166/406 (40%), Gaps = 45/406 (11%)
Query: 118 EAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDK 177
E + S+ +R+D R+ +V AG+ LEC G P P I W KD +
Sbjct: 6 EPLLNTGSVVPPSIREDGRK--ANVSGMAGQSLTLECDA-NGFPVPEIVWLKDAQLVGVP 62
Query: 178 ----------------EERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV 221
R+ G L ++ D+G+Y+C N G D L V
Sbjct: 63 LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRD-FHLLV 121
Query: 222 FERPTFLRRPINQVVLEEEA--VEFRCQVQGDPQPTVRWKKDDAD-LPRGRY-DIKDD-Y 276
P+ L Q VL VE +C G P P V W KD LP G + +++D
Sbjct: 122 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ 181
Query: 277 TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF--VVRPRDQIVAQGRTVTFP 334
LRI + DEG Y C+A + G+ L V APP + V + V
Sbjct: 182 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLL 241
Query: 335 CETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQAL 394
CE +G P P + W K+G+ L P + +R L + Q SDAG Y C+A
Sbjct: 242 CEARGVPTPNITWFKDGA---LLPTSTKVVYTRGG----RQLQLGRAQSSDAGVYTCKAS 294
Query: 395 TVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA----LLKCKATGDPLPVIS 450
G+ +L+V PP I +G + V A L+C A G P P +S
Sbjct: 295 NAVGAAEKATRLDVY------VPPTI-EGAGGRPYVVKAVAGRPVALECVARGHPSPTLS 347
Query: 451 WLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGE 496
W EG + + L++++ + +G Y+CVA+S +GE
Sbjct: 348 WHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGE 393
Score = 112 bits (280), Expect = 2e-24
Identities = 88/282 (31%), Positives = 120/282 (42%), Gaps = 19/282 (6%)
Query: 37 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIV 96
P D + G+ L C A G PTP I W T D P + + G R
Sbjct: 2853 PGDRSLRLGDRLWLRCAARGSPTPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA 2904
Query: 97 HGRRSKPDEGSYVCVARNYLG--EAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILEC 154
R D G+YVC A N +G +AVS E +L+ + +V G L+C
Sbjct: 2905 VSRE---DSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSY---LVEPVGGSIQLDC 2958
Query: 155 QPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDS 214
RG P P I+W KD + + R ++ G L I T + DAG Y C+ N +G
Sbjct: 2959 VV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKK 3017
Query: 215 DPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR-YDIK 273
L + P F P + V + V RCQ G+P PT+ W + L R
Sbjct: 3018 -VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL 3076
Query: 274 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQ 315
D +L ++ + D GTY C+A N +G A A L VR PQ
Sbjct: 3077 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3118
Score = 94.4 bits (233), Expect = 7e-19
Identities = 96/340 (28%), Positives = 126/340 (37%), Gaps = 42/340 (12%)
Query: 230 RPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA-------------DLPRGRYD----I 272
R N + +++ C G P P + W KD DL G+ +
Sbjct: 24 RKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLL 83
Query: 273 KDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVA--QGRT 330
+ +L + D G Y C AEN+ G + L V PP + Q V G
Sbjct: 84 DEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGAD 143
Query: 331 VTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS-RCSVSPTGD-LTITNIQRSDAGY 388
V C T G P P V W K+ QP P V G L IT D G
Sbjct: 144 VELQCWTSGVPTPQVEWTKD--------RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGR 195
Query: 389 YICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV--DGTALLKCKATGDPL 446
Y C A + AG QL V PP I +AV D L C+A G P
Sbjct: 196 YQCVAFSPAGQQARDFQLRV------HAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPT 249
Query: 447 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV- 505
P I+W K+G P + LQ+ + SD G YTC A+++ G + LDV
Sbjct: 250 PNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 309
Query: 506 ---TESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW 542
T GA + Y + + G P + S TLSW
Sbjct: 310 VPPTIEGAG-GRPYVVKAVAGRPVALECVARGHPSPTLSW 348
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 204 bits (520), Expect = 4e-52
Identities = 178/617 (28%), Positives = 271/617 (43%), Gaps = 73/617 (11%)
Query: 223 ERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYD-IKDDYT---- 277
E P F++ P +Q+ + F CQ GDP+P V W K + R++ I+ D +
Sbjct: 31 EPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAV 90
Query: 278 LRIKKTMST-DEGTYMCIAENRVGKMEASATLTVRAP-------PQFVVRPRDQIVAQGR 329
LRI+ + DE Y C+A+N VG++ A LTV P + P+ ++V + R
Sbjct: 91 LRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTR 150
Query: 330 TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 389
T T C GNP P + W K+ P P N R +G L I + + +D G Y
Sbjct: 151 TATMLCAASGNPDPEITWFKD-----FLPVDPSASNGRIKQLRSGALQIESSEETDQGKY 205
Query: 390 ICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVI 449
C A AG + V P IL P + + G + C A G P+P +
Sbjct: 206 ECVATNSAGVRYSSPANLYVRVRRVAPRFSIL--PMSHEIMPGGNVNITCVAVGSPMPYV 263
Query: 450 SWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESG 509
W++ D G ++ + D+ YTCVA SS G V E+
Sbjct: 264 KWMQGAEDLTPEDDMPV----GRNVLELTDVKDSANYTCVAMSSLG---------VIEAV 310
Query: 510 ATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQ 569
A I+ + LP P P VT+ T S+T++W G P P S Y+IE S+S +Q
Sbjct: 311 AQIT----VKSLPKAPGTPMVTENTATSITITWDSGNPD--PVSYYVIEYKSKSQDGPYQ 364
Query: 570 TVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQ 629
+ + TT Y++ GL PN+ Y V A+N G PS S RT + +P + R
Sbjct: 365 -IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSE-SVVTRTGEQAPASA---PRN 419
Query: 630 VQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQ-FIQGYRVMYRQTSGLQATSSWQ--N 686
VQ + L+ TT+ V W +P I+GYRV Y +WQ N
Sbjct: 420 VQARM------------LSATTMIVQWEEPVEPNGLIRGYRVYYTMEPE-HPVGNWQKHN 466
Query: 687 LDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVL 746
+D + T ++L + TY ++V + + G S+ V+T + P P L
Sbjct: 467 VDDSLLTTVGSLL----EDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMN----L 518
Query: 747 TVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFP 806
+ + TSI++SW PP Q II+ ++ G+ R + +T D S ++ L P
Sbjct: 519 RAEARSETSITLSWSPP---RQESIIKYELLFREGDHGR-EVGRTFDPT-TSYVVEDLKP 573
Query: 807 GIQYRVEVAASTSAGVG 823
+Y +AA + G+G
Sbjct: 574 NTEYAFRLAARSPQGLG 590
Score = 154 bits (388), Expect = 7e-37
Identities = 170/640 (26%), Positives = 263/640 (41%), Gaps = 82/640 (12%)
Query: 13 GFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 72
G L V + G +E PPR ++ P D I G + C+A G P P + W K G++V
Sbjct: 17 GLLVVLLVGGCAAEE--PPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN 74
Query: 73 TDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR 132
+ R + + LRI R+ DE Y CVA+N +GE ++ +A L V LR
Sbjct: 75 SQ----RFETIEFDESAGAVLRI-QPLRTPRDENVYECVAQNSVGE-ITVHAKLTV--LR 126
Query: 133 DD--------FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEE--RI- 181
+D P VV A + C G+P+P I W KD + +D RI
Sbjct: 127 EDQLPSGFPNIDMGPQLKVVERTRTATMLC-AASGNPDPEITWFKDFLPVDPSASNGRIK 185
Query: 182 SIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFER---PTFLRRPINQVVLE 238
+R G L I ++ ++D G Y CV TN G R S PA L V R P F P++ ++
Sbjct: 186 QLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMP 245
Query: 239 EEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLR---IKKTMSTDEGTYMCIA 295
V C G P P V+W + DL +DD + ++ T D Y C+A
Sbjct: 246 GGNVNITCVAVGSPMPYVKWMQGAEDLTP-----EDDMPVGRNVLELTDVKDSANYTCVA 300
Query: 296 ENRVGKMEASATLTVRAPPQFVVRPR-DQIVAQGRTVTFPCETKGNPQPAVFW---QKEG 351
+ +G +EA A +TV++ P+ P + A T+T+ GNP P ++ K
Sbjct: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITW---DSGNPDPVSYYVIEYKSK 357
Query: 352 SQNLLFPNQPQQPNSRCSV---SPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEV 408
SQ+ + + +R S+ SP + I ++ SI E
Sbjct: 358 SQDGPYQIKEDITTTRYSIGGLSPNSEYEIW--------------VSAVNSIGQGPPSES 403
Query: 409 TDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDP----- 463
T P + T +++ + +P +I + +T P
Sbjct: 404 VVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQ 463
Query: 464 RATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV-TESGATISKNYDLSDLP 522
+ + + + +L +T T +A +S G+ S + V T+ G +P
Sbjct: 464 KHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG-----------VP 512
Query: 523 GPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYII--EAFSQSVSNSWQTVANHVKTTLY 580
G P + ++ S+TLSW P P II E + + + TT Y
Sbjct: 513 GQPMNLRAEARSETSITLSWSP------PRQESIIKYELLFREGDHGREVGRTFDPTTSY 566
Query: 581 TVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISP 620
V L+PNT Y F + A +PQGL +P+ Q ISP
Sbjct: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSISP 606
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 203 bits (517), Expect = 8e-52
Identities = 234/880 (26%), Positives = 356/880 (40%), Gaps = 144/880 (16%)
Query: 9 LLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDG 68
LLL ++R D + PPR P D G + C+A G P P I W K G
Sbjct: 8 LLLLLTFFLRTDA------ETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKG 61
Query: 69 ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV 128
++V R + GS LRI R+ DE Y CVA N +GE + S +
Sbjct: 62 KKVSNQ----RFEVIEFDDGSGSVLRI-QPLRTPRDEAIYECVASNNVGEI---SVSTRL 113
Query: 129 ALLRDD--------FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEE- 179
+LR+D P VV A + C G+P+P I W KD + +D
Sbjct: 114 TVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAAS-GNPDPEITWFKDFLPVDTSNNN 172
Query: 180 -RIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFER---PTFLRRPINQ 234
RI +R G L I + +SD G Y CV TN G R S PA L V R P F P N
Sbjct: 173 GRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNH 232
Query: 235 VVLEEEAVEFRCQVQGDPQPTVRW--------KKDDADLPRGRYDIKDDYTLRIKKTMST 286
++ +V C G P P V+W +DD + R ++ D
Sbjct: 233 EIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELND----------VR 282
Query: 287 DEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCE-TKGNPQPAV 345
Y C+A + +G +EA A +TV+A P+ P +V + + GNP+P
Sbjct: 283 QSANYTCVAMSTLGVIEAIAQITVKALPK---PPGTPVVTESTATSITLTWDSGNPEPVS 339
Query: 346 FW---QKEGSQNLLFPNQPQQPNSRCSV---SPTGD-----LTITNIQRSDAGYYIC--- 391
++ K + L+ +R SV SP D + + NI R +
Sbjct: 340 YYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 399
Query: 392 --QALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP-V 448
QA + A + L T +L P + P Q + G + T DP V
Sbjct: 400 SEQAPSSAPRDVQARMLSSTTILVQWKEP---EEPNGQ---IQG---YRVYYTMDPTQHV 450
Query: 449 ISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV-TE 507
+W+K + + I NL T + +A +S G+ S+ + V T+
Sbjct: 451 NNWMKH-----------NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQ 499
Query: 508 SGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNS 567
+G +PG P + ++ S+ LSW P T+ A+ ++ +
Sbjct: 500 TG-----------VPGQPLNFKAEPESETSILLSWTPPRSDTI-ANYELVYKDGEHGEEQ 547
Query: 568 WQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDH 627
T+ T Y ++GL+PN++Y F + A +PQGL S RT P A D
Sbjct: 548 RITIE---PGTSYRLQGLKPNSLYYFRLAARSPQGLG-ASTAEISARTMQSKPSAPPQD- 602
Query: 628 RQVQKELGDVLVRLHNPVVLTPTTVQVTW---TVDRQPQFIQGYRVMYRQTSGLQATSSW 684
+ +P + T++ V+W V++Q I Y + Y G
Sbjct: 603 -----------ISCTSP---SSTSILVSWQPPPVEKQNGIITEYSIKYTAVDG---EDDK 645
Query: 685 QNLDAKVPTERSAVLV-NLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSV 743
+ +P++ + L+ L+K Y I V + + G +S S +RT E+ PS PP+ V
Sbjct: 646 PHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKV 705
Query: 744 TVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTV----------- 792
V V NSTS+ VSW P P+ Q+G I+ Y++ + E + +
Sbjct: 706 EVEAV---NSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQW 762
Query: 793 ---DAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQ 829
D +II GL P Y + V A T+ G G +S+P+
Sbjct: 763 EFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPK 802
Score = 69.3 bits (168), Expect = 2e-11
Identities = 184/888 (20%), Positives = 300/888 (33%), Gaps = 190/888 (21%)
Query: 15 LYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD 74
LYVRV PPR P++ + G + C A G P P ++W E + +
Sbjct: 214 LYVRV-------RRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE 266
Query: 75 KDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD 134
D P +L + R+S +Y CVA + LG + A + V L
Sbjct: 267 DDMPIGRNVL---------ELNDVRQS----ANYTCVAMSTLG-VIEAIAQITVKALP-- 310
Query: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTR 194
+ P VV + G+PEP Y+ + +E I G ++ TR
Sbjct: 311 --KPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDG----VATTR 364
Query: 195 KSDAGM-------YTCVGTNMVGERDSDPAELTVF--ERPTFLRRPINQVVLEEEAVEFR 245
S AG+ + V N +G LT + P+ R + +L +
Sbjct: 365 YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTI--- 421
Query: 246 CQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAEN-------R 298
V+WK+ + P G+ R+ TM + + N
Sbjct: 422 ---------LVQWKEPEE--PNGQIQ-----GYRVYYTMDPTQHVNNWMKHNVADSQITT 465
Query: 299 VGKMEASATLTVRA---------PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQK 349
+G + T +V+ P ++ Q G+ + F E + + W
Sbjct: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP 525
Query: 350 EGSQN-----LLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKA 404
S L++ + R ++ P + ++ + Y+ A + G + A
Sbjct: 526 PRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA 585
Query: 405 QLEV---------------------TDVLTD-RPPPI-----ILQGPANQTLAVDGTALL 437
++ T +L +PPP+ I+ + + AVDG
Sbjct: 586 EISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK 645
Query: 438 KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497
+ G P +L E E+ T RI T T G
Sbjct: 646 PHEILGIPSDTTKYLLEQL------------EKWT----EYRI----TVTAHTDVGPGPE 685
Query: 498 SWSAVLDVTESGATISKNYDLSDLP-GPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYI 556
S S ++ E D+P GPP K +V V SV +SW+ P
Sbjct: 686 SLSVLIRTNE------------DVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRG 733
Query: 557 IEAFSQSVSNSWQTVANHVKTTLYT---------------VRGLRPNTIYLFMVRAINPQ 601
+ + N +K + + GL+P T Y V A +
Sbjct: 734 YQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTK 793
Query: 602 GLSDPSPMSDP--VRTQDISP--PAQGVDHRQVQKELGDVLVRLHNPV-VLTPTTVQVTW 656
G S P V T P P ++H Q + L++ H PV P
Sbjct: 794 G---DGARSKPKLVSTTGAVPGKPRLVINHTQ----MNTALIQWHPPVDTFGP------- 839
Query: 657 TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYF 716
+QGYR+ + G + L+ E ++ KG +Y ++
Sbjct: 840 --------LQGYRLKF----GRKDMEPLTTLEFS-EKEDHFTATDIHKGASYVFRLSAR- 885
Query: 717 NEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYK 776
N+ + K + EE P+ PQ+ L STS+ +SW PP +NGII +Y
Sbjct: 886 NKVGFGEEMVKEISIPEEVPTGFPQN---LHSEGTTSTSVQLSWQPPVLAERNGIITKYT 942
Query: 777 IWCLG-NETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVG 823
+ N + + + A ++ + GL P Y V+V A TS G G
Sbjct: 943 LLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG 990
Score = 45.8 bits (107), Expect = 3e-04
Identities = 64/291 (21%), Positives = 111/291 (38%), Gaps = 37/291 (12%)
Query: 482 DTGTYTCVATSSSGETSWSAVLDV--TESGATISKNYDLSDLPGPPSKPQ--VTDVTKNS 537
DT + + + ETS+S + T+ SK +S P KP+ + N+
Sbjct: 766 DTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNT 825
Query: 538 VTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRA 597
+ W P P Y ++ F + T+ K +T + Y+F + A
Sbjct: 826 ALIQWHPPVDTFGPLQGYRLK-FGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA 884
Query: 598 INPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTW- 656
N G + ++IS P +E+ + + T T+VQ++W
Sbjct: 885 RNKVGFGEEM-------VKEISIP----------EEVPTGFPQNLHSEGTTSTSVQLSWQ 927
Query: 657 --TVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRP 714
+ + I Y ++YR + + Q + VP + + L LK TY++KVR
Sbjct: 928 PPVLAERNGIITKYTLLYRDIN-IPLLPMEQLI---VPADTTMTLTGLKPDTTYDVKVRA 983
Query: 715 YFNEFQGMDSESKTVRTTEEAPSAPPQSVTV--LTVGSYNSTSISVSWDPP 763
+ ++ G S S RT P V V + TS+ +SW+ P
Sbjct: 984 HTSKGPGPYSPSVQFRT------LPVDQVFAKNFHVKAVMKTSVLLSWEIP 1028
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 203 bits (516), Expect = 1e-51
Identities = 211/769 (27%), Positives = 328/769 (42%), Gaps = 105/769 (13%)
Query: 99 RRSKPDEGSYVCVARNYLG----EAVSRNASLEVALLRDDFR--------QNPTDVVVAA 146
R + D G+Y C+A +++ S+ A L +A +D R + P +
Sbjct: 196 RTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAA--EDTRLFAPSIKARFPAETYALV 253
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDK-EERISIRGGKLMISNTRKSDAGMYTCVG 205
G+ LEC G+P P I W+K +D + + L I + D G Y C
Sbjct: 254 GQQVTLECFA-FGNPVPRIKWRK----VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEA 308
Query: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEA-----VEFRCQVQGDPQPTVRWKK 260
N G RD+ + V +P +L+ V+ + EA + + C G P+PTVRW +
Sbjct: 309 ENSKG-RDTVQGRIIVQAQPEWLK-----VISDTEADIGSNLRWGCAAAGKPRPTVRWLR 362
Query: 261 DDADLP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA-PPQFVV 318
+ L + R ++ LR K D G Y C+AEN+ G + ASA L V+A P F +
Sbjct: 363 NGEPLASQNRVEVLAG-DLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRL 421
Query: 319 RPRDQIV--AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL 376
P +++ A+G + PC+ + P+ V W K G++ L+ +SR +V+P G L
Sbjct: 422 NPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-GTEILV-------NSSRVTVTPDGTL 473
Query: 377 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL 436
I NI RSD G Y C A G + T +L+ R I P++ + +
Sbjct: 474 IIRNISRSDEGKYTCFAENFMG------KANSTGILSVRDATKITLAPSSADINLGDNLT 527
Query: 437 LKCKATGDPLP--VISWLKEGFTF----PGRDPRATIQEQ--GTLQIKNLRISDTGTYTC 488
L+C A+ DP +W + F PG R T ++ G L I N ++ G YTC
Sbjct: 528 LQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTC 587
Query: 489 VATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPG 548
+A + V+D AT+ + PGPP V D+ ++ LSW G
Sbjct: 588 MAQT---------VVDSASKEATVL----VRGPPGPPGGVVVRDIGDTTIQLSWSRGFDN 634
Query: 549 TLPASAYIIEAFSQSVSNSWQTVAN--HVKTTLYT--VRGLRPNTIYLFMVRAINPQGLS 604
P + Y ++A + Q N +++ T V GL P Y F V A N G
Sbjct: 635 HSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTG 694
Query: 605 DPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT-VDRQPQ 663
+PS S +RT++ +P G+++V WT + R+ Q
Sbjct: 695 EPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVN---------------WTPMSREYQ 739
Query: 664 FIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVT----YEIKVRPYFNEF 719
G+ Y + Q ++ WQ A+VP + V + V +E+K+R Y
Sbjct: 740 NGDGFG--YLLSFRRQGSTHWQT--ARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRG 795
Query: 720 QGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-- 777
G +S + V + EE P P V V +S+ ++V+W+P D NGI+ Y+I
Sbjct: 796 DGPESLTALVYSAEEEPRVAPTKVWAKGV---SSSEMNVTWEPVQQD-MNGILLGYEIRY 851
Query: 778 WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 826
W G++ S + GL P +Y V V A AG G S
Sbjct: 852 WKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPAS 900
Score = 169 bits (429), Expect = 1e-41
Identities = 200/776 (25%), Positives = 306/776 (39%), Gaps = 97/776 (12%)
Query: 26 QEDFPPRIVEHPSDVIV---SKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHR 82
Q F P + P V+ S E L C+A P T W +G + K +P S
Sbjct: 32 QTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEM---KLEPGSRH 88
Query: 83 MLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV 142
L+ G+L ++ D G Y C+A N +G VSR A L L++ ++ V
Sbjct: 89 QLV-GGNL----VIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPV 143
Query: 143 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRI---DDKEERISIRGGKLMISNTRKSDAG 199
G +L C PP +P + W ++ D +S G L I+ T SD G
Sbjct: 144 KAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG 203
Query: 200 MYTCVGTNMVGERD----SDPAELTVFERPTFL-------RRPINQVVLEEEAVEFRCQV 248
Y+C+ T+ + S A+L + T L R P L + V C
Sbjct: 204 NYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFA 263
Query: 249 QGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL 308
G+P P ++W+K D L + TL+I DEGTY C AEN G+ +
Sbjct: 264 FGNPVPRIKWRKVDGSLSPQWTTAEP--TLQIPSVSFEDEGTYECEAENSKGRDTVQGRI 321
Query: 309 TVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRC 368
V+A P+++ D G + + C G P+P V W + G +P +R
Sbjct: 322 IVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNG--------EPLASQNRV 373
Query: 369 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTD-RPPPIILQGPANQ 427
V GDL + + D+G Y C A G+I A A+L V + D R P+ PA
Sbjct: 374 EVL-AGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPA-- 430
Query: 428 TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487
A G L+ C+ P V+ W K G R T+ GTL I+N+ SD G YT
Sbjct: 431 --ARGGEILIPCQPRAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYT 487
Query: 488 CVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTP 547
C A + G+ + + +L V D + + PS + +++TL
Sbjct: 488 CFAENFMGKANSTGILSVR----------DATKITLAPSSADIN--LGDNLTLQCHASHD 535
Query: 548 GTLPAS-AYIIEAFSQSVSN-SWQTVANHVKTTLYTV----RGLRPNTIYLFMVRAINPQ 601
T+ + + ++ F +VK T+ + LR Y M Q
Sbjct: 536 PTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMA-----Q 590
Query: 602 GLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT---V 658
+ D + V + P GV V +++GD TT+Q++W+
Sbjct: 591 TVVDSASKEATVLVRGPPGPPGGV----VVRDIGD-------------TTIQLSWSRGFD 633
Query: 659 DRQPQFIQGYRVMYRQTSG---LQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPY 715
+ P I Y + R Q ++ N++ T A ++ L + YE +V
Sbjct: 634 NHSP--IAKYTLQARTPPAGKWKQVRTNPANIEGNAET---AQVLGLTPWMDYEFRVIAS 688
Query: 716 FNEFQGMDS-ESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNG 770
G S S +RT E APS P L+ G + V+W P ++QNG
Sbjct: 689 NILGTGEPSGPSSKIRTREAAPSVAPSG---LSGGGGAPGELIVNWTPMSREYQNG 741
Score = 147 bits (372), Expect = 5e-35
Identities = 199/795 (25%), Positives = 304/795 (38%), Gaps = 128/795 (16%)
Query: 29 FPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRMLLP 86
F P I P++ G+ TL C A G P P I+W K DG + + + +P
Sbjct: 237 FAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSL--SPQWTTAEPTLQIP 294
Query: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA 146
S S DEG+Y C A N G + + A + ++ + +D
Sbjct: 295 SVSF------------EDEGTYECEAENSKGRDTVQGRIIVQA--QPEWLKVISDTEADI 340
Query: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGT 206
G C G P PT+ W ++ + + R+ + G L S D+GMY CV
Sbjct: 341 GSNLRWGCAAA-GKPRPTVRWLRNGEPLAS-QNRVEVLAGDLRFSKLSLEDSGMYQCVAE 398
Query: 207 NMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVEFR--CQVQGDPQPTVRWKKDDA 263
N G + AEL V P F P+ +++ E CQ + P+ V W K
Sbjct: 399 NKHGTIYAS-AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTE 457
Query: 264 DLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRD 322
L R + D TL I+ +DEG Y C AEN +GK ++ L+VR + + P
Sbjct: 458 ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSS 517
Query: 323 QIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT-GDLTITNI 381
+ G +T C +P + + + ++P R +V T GDLTI N
Sbjct: 518 ADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNA 577
Query: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 441
Q G Y C A TV S A E T VL PP GP + D
Sbjct: 578 QLRHGGKYTCMAQTVVDS----ASKEAT-VLVRGPP-----GPPGGVVVRD--------- 618
Query: 442 TGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS---GETS 498
GD +SW + G D + I + TLQ R G + V T+ + G
Sbjct: 619 IGDTTIQLSWSR------GFDNHSPIAKY-TLQ---ARTPPAGKWKQVRTNPANIEGNAE 668
Query: 499 WSAVLDVT-----ESGATISKNYDLSDLPGPPSKPQVTDVTKNSVT--LSWQPGTPGTL- 550
+ VL +T E S + GP SK + + + LS G PG L
Sbjct: 669 TAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELI 728
Query: 551 ----PAS---------AYIIEAFSQSVSNSWQTV---ANHVKTTLYTVRGLRPNTIYLFM 594
P S Y++ +F + S WQT + +Y+ +RP T +
Sbjct: 729 VNWTPMSREYQNGDGFGYLL-SFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVK 787
Query: 595 VRAINPQGLSDPSPMSDPVRTQDISPP-------AQGVDHRQVQKELGDVLVRLHNPVVL 647
+R+ N +G P ++ V + + P A+GV
Sbjct: 788 IRSYNRRG-DGPESLTALVYSAEEEPRVAPTKVWAKGV---------------------- 824
Query: 648 TPTTVQVTWTVDRQPQ--FIQGYRVMYRQTSGLQATSSWQNLDAKVPT---ERSAVLVNL 702
+ + + VTW +Q + GY + Y + +A + +V T + SA + L
Sbjct: 825 SSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAAD------RVRTAGLDTSARVSGL 878
Query: 703 KKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDP 762
Y + VR Y G S S T + P PP +++ +++S+S+S+ WDP
Sbjct: 879 HPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNIS----WTFSSSSLSIKWDP 934
Query: 763 PPPDHQNGIIQEYKI 777
P + YK+
Sbjct: 935 VVPFRNESAVTGYKM 949
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 200 bits (509), Expect = 7e-51
Identities = 212/836 (25%), Positives = 338/836 (40%), Gaps = 87/836 (10%)
Query: 23 RLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHR 82
RL E P E V V +GE L C P ++ + + + +D+ +
Sbjct: 124 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT-- 181
Query: 83 MLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-------- 134
+ +G+L+F ++ + + Y+C A + + +++ + +
Sbjct: 182 -MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPR 236
Query: 135 --FRQNPTDVVVAA-GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMIS 191
F N + +VA G+P +LEC G P PTI W + + L +
Sbjct: 237 LLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLL 295
Query: 192 NTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD 251
+ D G Y C+ N +G +TV P +L +P + + E CQVQG
Sbjct: 296 KVGEEDDGEYRCLAENSLGSA-RHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGR 354
Query: 252 PQPTVRWKKDDADLPRGRYDIK---DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL 308
PQP V W+ + + D K L + +D C A NR G + A+A +
Sbjct: 355 PQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYI 414
Query: 309 TVRAPPQFVVRPRDQ--IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS 366
V P ++ +Q + QG T C+ G P P+V W E +L +
Sbjct: 415 YVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-------QDE 467
Query: 367 RCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPAN 426
R G L I ++Q +D G Y C A ++ A L+V D I QGP +
Sbjct: 468 RFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ------ITQGPRS 521
Query: 427 QTLAVDGTALLKCKATGDPL--PVISWLKEGFTFPGR-DPRATIQEQGTLQIKNLRISDT 483
C+A+ DP P I+W +G D E G L I +L SD
Sbjct: 522 TIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 581
Query: 484 GTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDV---TKNSVTL 540
G Y+CVA++ LDV ES A + + PGP + ++D+ T++ V +
Sbjct: 582 GNYSCVASTE---------LDVVESRAQLL----VVGSPGPVPRLVLSDLHLLTQSQVRV 628
Query: 541 SWQPGTPGTLPASAYIIEAFSQSVS-NSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAIN 599
SW P P Y IE + ++ W ++ T L P Y F V AIN
Sbjct: 629 SWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAIN 688
Query: 600 PQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVD 659
G +PSP+S+ V T + +P VD + E ++++ T + W
Sbjct: 689 KYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI----------TWKPLRWMDW 738
Query: 660 RQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEF 719
PQ YRV +R WQ ++ ++ V+ N V YEIKV+ ++
Sbjct: 739 NAPQV--QYRVQWRPQG---TRGPWQE---QIVSDPFLVVSNTSTFVPYEIKVQAVNSQG 790
Query: 720 QGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-- 777
+G + + + E+ P A P+ + + NS+++ V W P G ++ Y +
Sbjct: 791 KGPEPQVTIGYSGEDYPQAIPE---LEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTY 847
Query: 778 WCLGNE---TRFHINK---TVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 827
W G++ ++ HI+K V A SVI+ GL P Y +EV A G G SE
Sbjct: 848 WREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE 903
Score = 187 bits (476), Expect = 5e-47
Identities = 143/500 (28%), Positives = 228/500 (45%), Gaps = 37/500 (7%)
Query: 30 PPRIVEH-PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88
PP I E P ++V + +L C+A G+P W +DG + ++ + SG
Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88
Query: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVV----V 144
S F + + ++ +G Y C A N LG A+S E+ L+ + + P + V V
Sbjct: 89 S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSH----EIRLMAEGAPKWPKETVKPVEV 143
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGMYTC 203
GE +L C PP IYW K+ ++ER+++ + G L +N SD
Sbjct: 144 EEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYI 203
Query: 204 VGTNMVGER---DSDPAELTV------FERPTFLRRPINQ----VVLEEEAVEFRCQVQG 250
+ G R +P +L V +R L P N V L+ + + C +G
Sbjct: 204 CHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEG 263
Query: 251 DPQPTVRWKKDDADLPRGRYDIKD-DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 309
P PT++W + +P R ++ + TL++ K D+G Y C+AEN +G + +T
Sbjct: 264 FPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVT 323
Query: 310 VRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS 369
V A P ++ +P+ + G T C+ +G PQP V W+ G P + + +
Sbjct: 324 VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKYR 378
Query: 370 VSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL 429
+ G L ++N+Q SD C+A G +LA A + V + P IL +
Sbjct: 379 IQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL-----PAKILTADNQTYM 432
Query: 430 AVDG-TALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTC 488
AV G TA L CKA G P+P + WL E T +D R GTL I++L+ +DTG Y C
Sbjct: 433 AVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFC 492
Query: 489 VATSSSGETSWSAVLDVTES 508
+A + + A L V ++
Sbjct: 493 LAANDQNNVTIMANLKVKDA 512
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 200 bits (509), Expect = 7e-51
Identities = 212/836 (25%), Positives = 338/836 (40%), Gaps = 87/836 (10%)
Query: 23 RLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHR 82
RL E P E V V +GE L C P ++ + + + +D+ +
Sbjct: 129 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT-- 186
Query: 83 MLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-------- 134
+ +G+L+F ++ + + Y+C A + + +++ + +
Sbjct: 187 -MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPR 241
Query: 135 --FRQNPTDVVVAA-GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMIS 191
F N + +VA G+P +LEC G P PTI W + + L +
Sbjct: 242 LLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLL 300
Query: 192 NTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGD 251
+ D G Y C+ N +G +TV P +L +P + + E CQVQG
Sbjct: 301 KVGEEDDGEYRCLAENSLGSA-RHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGR 359
Query: 252 PQPTVRWKKDDADLPRGRYDIK---DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL 308
PQP V W+ + + D K L + +D C A NR G + A+A +
Sbjct: 360 PQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYI 419
Query: 309 TVRAPPQFVVRPRDQ--IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS 366
V P ++ +Q + QG T C+ G P P+V W E +L +
Sbjct: 420 YVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-------QDE 472
Query: 367 RCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPAN 426
R G L I ++Q +D G Y C A ++ A L+V D I QGP +
Sbjct: 473 RFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ------ITQGPRS 526
Query: 427 QTLAVDGTALLKCKATGDPL--PVISWLKEGFTFPGR-DPRATIQEQGTLQIKNLRISDT 483
C+A+ DP P I+W +G D E G L I +L SD
Sbjct: 527 TIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQ 586
Query: 484 GTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDV---TKNSVTL 540
G Y+CVA++ LDV ES A + + PGP + ++D+ T++ V +
Sbjct: 587 GNYSCVASTE---------LDVVESRAQLL----VVGSPGPVPRLVLSDLHLLTQSQVRV 633
Query: 541 SWQPGTPGTLPASAYIIEAFSQSVS-NSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAIN 599
SW P P Y IE + ++ W ++ T L P Y F V AIN
Sbjct: 634 SWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAIN 693
Query: 600 PQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVD 659
G +PSP+S+ V T + +P VD + E ++++ T + W
Sbjct: 694 KYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI----------TWKPLRWMDW 743
Query: 660 RQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEF 719
PQ YRV +R WQ ++ ++ V+ N V YEIKV+ ++
Sbjct: 744 NAPQV--QYRVQWRPQG---TRGPWQE---QIVSDPFLVVSNTSTFVPYEIKVQAVNSQG 795
Query: 720 QGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-- 777
+G + + + E+ P A P+ + + NS+++ V W P G ++ Y +
Sbjct: 796 KGPEPQVTIGYSGEDYPQAIPE---LEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTY 852
Query: 778 WCLGNE---TRFHINK---TVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 827
W G++ ++ HI+K V A SVI+ GL P Y +EV A G G SE
Sbjct: 853 WREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE 908
Score = 187 bits (476), Expect = 5e-47
Identities = 143/500 (28%), Positives = 228/500 (45%), Gaps = 37/500 (7%)
Query: 30 PPRIVEH-PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88
PP I E P ++V + +L C+A G+P W +DG + ++ + SG
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVV----V 144
S F + + ++ +G Y C A N LG A+S E+ L+ + + P + V V
Sbjct: 94 S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSH----EIRLMAEGAPKWPKETVKPVEV 148
Query: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGMYTC 203
GE +L C PP IYW K+ ++ER+++ + G L +N SD
Sbjct: 149 EEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYI 208
Query: 204 VGTNMVGER---DSDPAELTV------FERPTFLRRPINQ----VVLEEEAVEFRCQVQG 250
+ G R +P +L V +R L P N V L+ + + C +G
Sbjct: 209 CHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEG 268
Query: 251 DPQPTVRWKKDDADLPRGRYDIKD-DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLT 309
P PT++W + +P R ++ + TL++ K D+G Y C+AEN +G + +T
Sbjct: 269 FPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVT 328
Query: 310 VRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCS 369
V A P ++ +P+ + G T C+ +G PQP V W+ G P + + +
Sbjct: 329 VEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKYR 383
Query: 370 VSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTL 429
+ G L ++N+Q SD C+A G +LA A + V + P IL +
Sbjct: 384 IQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL-----PAKILTADNQTYM 437
Query: 430 AVDG-TALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTC 488
AV G TA L CKA G P+P + WL E T +D R GTL I++L+ +DTG Y C
Sbjct: 438 AVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFC 497
Query: 489 VATSSSGETSWSAVLDVTES 508
+A + + A L V ++
Sbjct: 498 LAANDQNNVTIMANLKVKDA 517
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,786,036
Number of Sequences: 37866
Number of extensions: 3380250
Number of successful extensions: 24326
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 304
Number of HSP's successfully gapped in prelim test: 395
Number of HSP's that attempted gapping in prelim test: 11525
Number of HSP's gapped (non-prelim): 5397
length of query: 1378
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1263
effective length of database: 13,892,928
effective search space: 17546768064
effective search space used: 17546768064
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.