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Search of human proteins with 61743946
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61743946 abl-interactor 1 isoform c [Homo sapiens]
(452 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61743946 abl-interactor 1 isoform c [Homo sapiens] 929 0.0
gi|61743944 abl-interactor 1 isoform b [Homo sapiens] 913 0.0
gi|61743942 abl-interactor 1 isoform a [Homo sapiens] 899 0.0
gi|61743948 abl-interactor 1 isoform d [Homo sapiens] 896 0.0
gi|109689723 abl interactor 2 [Homo sapiens] 650 0.0
gi|7705981 NESH protein isoform 1 [Homo sapiens] 275 5e-74
gi|206597502 NESH protein isoform 2 [Homo sapiens] 266 3e-71
gi|55956916 myosin IE [Homo sapiens] 67 4e-11
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 65 1e-10
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 65 1e-10
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 65 1e-10
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 65 1e-10
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 65 1e-10
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 61 2e-09
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 61 2e-09
gi|27544941 myosin IF [Homo sapiens] 60 3e-09
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 59 7e-09
gi|55741677 SET domain containing 1A [Homo sapiens] 59 1e-08
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 59 1e-08
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 58 2e-08
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 58 2e-08
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 58 2e-08
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 58 2e-08
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 58 2e-08
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 58 2e-08
gi|20357552 cortactin isoform a [Homo sapiens] 58 2e-08
gi|20357556 cortactin isoform b [Homo sapiens] 58 2e-08
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens] 57 3e-08
gi|55750053 atrophin-1 [Homo sapiens] 56 6e-08
gi|55750041 atrophin-1 [Homo sapiens] 56 6e-08
>gi|61743946 abl-interactor 1 isoform c [Homo sapiens]
Length = 452
Score = 929 bits (2400), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS
Sbjct: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
Sbjct: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK
Sbjct: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS
Sbjct: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300
GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS
Sbjct: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300
Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPP 360
TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPP
Sbjct: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPP 360
Query: 361 PPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVI 420
PPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVI
Sbjct: 361 PPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVI 420
Query: 421 KKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD 452
KKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD
Sbjct: 421 KKNDDGWYEGVCNRVTGLFPGNYVESIMHYTD 452
>gi|61743944 abl-interactor 1 isoform b [Homo sapiens]
Length = 481
Score = 913 bits (2360), Expect = 0.0
Identities = 452/481 (93%), Positives = 452/481 (93%), Gaps = 29/481 (6%)
Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS
Sbjct: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
Sbjct: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK
Sbjct: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS
Sbjct: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300
GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS
Sbjct: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300
Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNS---------------------------- 332
TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNS
Sbjct: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 360
Query: 333 -IADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 391
IADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY
Sbjct: 361 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 420
Query: 392 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 451
IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT
Sbjct: 421 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 480
Query: 452 D 452
D
Sbjct: 481 D 481
>gi|61743942 abl-interactor 1 isoform a [Homo sapiens]
Length = 508
Score = 899 bits (2322), Expect = 0.0
Identities = 452/508 (88%), Positives = 452/508 (88%), Gaps = 56/508 (11%)
Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS
Sbjct: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
Sbjct: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK
Sbjct: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS
Sbjct: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP--------------------------- 273
GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP
Sbjct: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVI 300
Query: 274 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNS- 332
AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNS
Sbjct: 301 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI 360
Query: 333 ----------------------------IADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD 364
IADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD
Sbjct: 361 SIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD 420
Query: 365 YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND 424
YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND
Sbjct: 421 YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND 480
Query: 425 DGWYEGVCNRVTGLFPGNYVESIMHYTD 452
DGWYEGVCNRVTGLFPGNYVESIMHYTD
Sbjct: 481 DGWYEGVCNRVTGLFPGNYVESIMHYTD 508
>gi|61743948 abl-interactor 1 isoform d [Homo sapiens]
Length = 476
Score = 896 bits (2315), Expect = 0.0
Identities = 447/481 (92%), Positives = 447/481 (92%), Gaps = 34/481 (7%)
Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS
Sbjct: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
Sbjct: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVK HGNNQPARTGTLSRTNPPTQK
Sbjct: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVK-----HGNNQPARTGTLSRTNPPTQK 175
Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS
Sbjct: 176 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 235
Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300
GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS
Sbjct: 236 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 295
Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNS---------------------------- 332
TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNS
Sbjct: 296 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQE 355
Query: 333 -IADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 391
IADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY
Sbjct: 356 NIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNY 415
Query: 392 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 451
IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT
Sbjct: 416 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESIMHYT 475
Query: 452 D 452
D
Sbjct: 476 D 476
>gi|109689723 abl interactor 2 [Homo sapiens]
Length = 475
Score = 650 bits (1677), Expect = 0.0
Identities = 337/488 (69%), Positives = 381/488 (78%), Gaps = 49/488 (10%)
Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
MAELQMLLEEEIP G+RAL +SY NL RVADYCENNYIQ+ DK++ALEETKAYTTQSLAS
Sbjct: 1 MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQRALEETKAYTTQSLAS 60
Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
VAY IN LANNVLQ+LDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
Sbjct: 61 VAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
THKIIAPAN+ERPVRYIRKPIDYT+LDD+GHGVK + Q + G L RT PPTQK
Sbjct: 121 THKIIAPANLERPVRYIRKPIDYTILDDIGHGVK------VSTQNMKMGGLPRTTPPTQK 174
Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPAR--LGSQHSPGRTASLNQRPRT 238
PPSPPMSG+GTLGR++PY+TLEPV+PP VPNDY+ SP R SQ SP RTAS+NQR RT
Sbjct: 175 PPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRT 234
Query: 239 H--SGSSGG------SGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQ 290
+ SGSSGG S SRENSGS S+G+PIAVPTPSPP++ P P Q+ +M R
Sbjct: 235 YSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPGHP-----VQFYSMNRP 289
Query: 291 ISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTP----------- 339
SRH T S YRR PS+T+Q S Q +NGGP YSQN ++ +P P
Sbjct: 290 ASRHTPPTIG-GSLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSLAPPPPSILQVTPQLP 348
Query: 340 ---------------PPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDP 384
PPPPPP + P+FD+SPPPPPPP DYE+EEAAVV+Y+DPYA+ DP
Sbjct: 349 LMGFVARVQENISDTPPPPPPVEEPVFDESPPPPPPPE-DYEEEEAAVVEYSDPYAEEDP 407
Query: 385 AWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYV 444
WAP++Y+EKVVAIYDYTKDK+DELSF EGAIIYVIKKNDDGWYEGV N VTGLFPGNYV
Sbjct: 408 PWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYV 467
Query: 445 ESIMHYTD 452
ESIMHY++
Sbjct: 468 ESIMHYSE 475
>gi|7705981 NESH protein isoform 1 [Homo sapiens]
Length = 366
Score = 275 bits (704), Expect = 5e-74
Identities = 178/445 (40%), Positives = 239/445 (53%), Gaps = 82/445 (18%)
Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
MAELQ L E EIP+G+ AL ++ L RVADYCE+NY+QATDKRKALEET A+TTQ+LAS
Sbjct: 1 MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALAS 60
Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
VAYQ+ LA + L++LD+Q + LR++E+ ++ + Q V++H EKVARREIG L T +
Sbjct: 61 VAYQVGNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPP 120
Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
K+IAP N+ Y R+P+++ LDD+GHG+K L + Q +RTGTLSR + K
Sbjct: 121 GQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDL-----STQLSRTGTLSR---KSIK 172
Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
P+ P S TLGR P + EPV P VP+ RL + S AS +
Sbjct: 173 APATPAS--ATLGR--PPRIPEPVHLPVVPD------GRLSAASSASSLAS--------A 214
Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300
GS+ G G PTP G AAP + P
Sbjct: 215 GSAEGVG--------------GAPTPK----GQAAPPAPP-------------------L 237
Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPP 360
SS P+ F P + PPPP +++P+ D PPPPP
Sbjct: 238 PSSLDPPPPPAAVEVFQRPPTLE--------------ELSPPPPDEELPLPLDLPPPPP- 282
Query: 361 PPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVI 420
+ +E + + +P+W P +Y+EKVV +Y YT KD+ELSF EG +I V
Sbjct: 283 ----LDGDELGLPPPPPGFGPDEPSWVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVT 338
Query: 421 KKNDDGWYEGVCNRVTGLFPGNYVE 445
++ DGW EGV + TG FPGNYVE
Sbjct: 339 RRYSDGWCEGVSSEGTGFFPGNYVE 363
>gi|206597502 NESH protein isoform 2 [Homo sapiens]
Length = 360
Score = 266 bits (680), Expect = 3e-71
Identities = 177/445 (39%), Positives = 236/445 (53%), Gaps = 88/445 (19%)
Query: 1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS 60
MAELQ L E EIP+G+ AL ++ L RVADYCE+NY+QATDKRKALEET A+TTQ+LAS
Sbjct: 1 MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALAS 60
Query: 61 VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR 120
VAYQ+ LA + L++LD+Q + LR++E ++ V++H EKVARREIG L T +
Sbjct: 61 VAYQVGNLAGHTLRMLDLQGAALRQVE------ARMVNMHMEKVARREIGTLATVQRLPP 114
Query: 121 THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK 180
K+IAP N+ Y R+P+++ LDD+GHG+K L + Q +RTGTLSR + K
Sbjct: 115 GQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDL-----STQLSRTGTLSR---KSIK 166
Query: 181 PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS 240
P+ P S TLGR P + EPV P VP+ RL + S AS +
Sbjct: 167 APATPAS--ATLGR--PPRIPEPVHLPVVPD------GRLSAASSASSLAS--------A 208
Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSS 300
GS+ G G PTP G AAP + P
Sbjct: 209 GSAEGVG--------------GAPTPK----GQAAPPAPP-------------------L 231
Query: 301 TSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPP 360
SS P+ F P + PPPP +++P+ D PPPPP
Sbjct: 232 PSSLDPPPPPAAVEVFQRPPTLE--------------ELSPPPPDEELPLPLDLPPPPP- 276
Query: 361 PPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVI 420
+ +E + + +P+W P +Y+EKVV +Y YT KD+ELSF EG +I V
Sbjct: 277 ----LDGDELGLPPPPPGFGPDEPSWVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVT 332
Query: 421 KKNDDGWYEGVCNRVTGLFPGNYVE 445
++ DGW EGV + TG FPGNYVE
Sbjct: 333 RRYSDGWCEGVSSEGTGFFPGNYVE 357
>gi|55956916 myosin IE [Homo sapiens]
Length = 1108
Score = 66.6 bits (161), Expect = 4e-11
Identities = 64/225 (28%), Positives = 91/225 (40%), Gaps = 21/225 (9%)
Query: 241 GSSGGSGSRENSGSSSIGIPIAVPTPSPP----TIGPAAPGSAPGSQYGTMTRQISRHNS 296
G GSR+ G +AV PS +IGP P ++ ++ T Q + ++S
Sbjct: 887 GPWSAGGSRQVQFHQGFG-DLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTT--QNTGYSS 943
Query: 297 TTSSTS--------SGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDI 348
T + + GY + + Q+ PH G +Q S+ S PP P
Sbjct: 944 GTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQST 1003
Query: 349 PMFDDSPPPPPPPPVDYEDEEAAVVQYND----PYADG--DPAWAPKNYIEKVVAIYDYT 402
S P + D+ AA V+ P A G P PK + + A+Y Y
Sbjct: 1004 SSDRVSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYD 1063
Query: 403 KDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
DELSF II +IK++ GW+ G GLFP NYV I
Sbjct: 1064 AQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI 1108
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 65.5 bits (158), Expect = 1e-10
Identities = 30/62 (48%), Positives = 44/62 (70%), Gaps = 3/62 (4%)
Query: 384 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 443
PA+ P + +V+A+YDY + +DELSF +G +I V+ K+D W++G N VTGLFP NY
Sbjct: 1097 PAFHP---VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNY 1153
Query: 444 VE 445
V+
Sbjct: 1154 VK 1155
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 6/87 (6%)
Query: 359 PPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIY 418
P V E+ EA N P A + E+ +A+Y Y+ + +L+F EG I
Sbjct: 928 PGSEVKREEPEALYAAVNKK-----PTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL 982
Query: 419 VIKKNDDGWYEGVCNRVTGLFPGNYVE 445
V +K D W+ G +G+FP NYV+
Sbjct: 983 VTQK-DGEWWTGSIGDRSGIFPSNYVK 1008
Score = 36.6 bits (83), Expect = 0.048
Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYVIKK--NDDGWYEGVCNRVTGLFPGNYVESI 447
A+Y + DE+SF G II V +K + GW G G FP NYVE +
Sbjct: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 789
Score = 35.0 bits (79), Expect = 0.14
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 5/50 (10%)
Query: 401 YTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNYVE 445
Y ++LS G +I ++KKN GW++G R G FP ++V+
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1086
Score = 33.9 bits (76), Expect = 0.31
Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 394 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
K A+ +T KD+ L+F + II V+++ ++ W+ G + G FP +YV+ I
Sbjct: 875 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWF-GEVHGGRGWFPKSYVKII 927
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 65.5 bits (158), Expect = 1e-10
Identities = 30/62 (48%), Positives = 44/62 (70%), Gaps = 3/62 (4%)
Query: 384 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 443
PA+ P + +V+A+YDY + +DELSF +G +I V+ K+D W++G N VTGLFP NY
Sbjct: 1124 PAFHP---VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNY 1180
Query: 444 VE 445
V+
Sbjct: 1181 VK 1182
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 6/87 (6%)
Query: 359 PPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIY 418
P V E+ EA N P A + E+ +A+Y Y+ + +L+F EG I
Sbjct: 955 PGSEVKREEPEALYAAVNKK-----PTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL 1009
Query: 419 VIKKNDDGWYEGVCNRVTGLFPGNYVE 445
V +K D W+ G +G+FP NYV+
Sbjct: 1010 VTQK-DGEWWTGSIGDRSGIFPSNYVK 1035
Score = 36.6 bits (83), Expect = 0.048
Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYVIKK--NDDGWYEGVCNRVTGLFPGNYVESI 447
A+Y + DE+SF G II V +K + GW G G FP NYVE +
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 816
Score = 35.0 bits (79), Expect = 0.14
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 5/50 (10%)
Query: 401 YTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNYVE 445
Y ++LS G +I ++KKN GW++G R G FP ++V+
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1113
Score = 33.9 bits (76), Expect = 0.31
Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 394 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
K A+ +T KD+ L+F + II V+++ ++ W+ G + G FP +YV+ I
Sbjct: 902 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWF-GEVHGGRGWFPKSYVKII 954
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 65.5 bits (158), Expect = 1e-10
Identities = 30/62 (48%), Positives = 44/62 (70%), Gaps = 3/62 (4%)
Query: 384 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 443
PA+ P + +V+A+YDY + +DELSF +G +I V+ K+D W++G N VTGLFP NY
Sbjct: 1124 PAFHP---VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNY 1180
Query: 444 VE 445
V+
Sbjct: 1181 VK 1182
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 6/87 (6%)
Query: 359 PPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIY 418
P V E+ EA N P A + E+ +A+Y Y+ + +L+F EG I
Sbjct: 955 PGSEVKREEPEALYAAVNKK-----PTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEIL 1009
Query: 419 VIKKNDDGWYEGVCNRVTGLFPGNYVE 445
V +K D W+ G +G+FP NYV+
Sbjct: 1010 VTQK-DGEWWTGSIGDRSGIFPSNYVK 1035
Score = 36.6 bits (83), Expect = 0.048
Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYVIKK--NDDGWYEGVCNRVTGLFPGNYVESI 447
A+Y + DE+SF G II V +K + GW G G FP NYVE +
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 816
Score = 35.0 bits (79), Expect = 0.14
Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 5/50 (10%)
Query: 401 YTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNYVE 445
Y ++LS G +I ++KKN GW++G R G FP ++V+
Sbjct: 1064 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVK 1113
Score = 33.9 bits (76), Expect = 0.31
Identities = 18/54 (33%), Positives = 32/54 (59%), Gaps = 1/54 (1%)
Query: 394 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
K A+ +T KD+ L+F + II V+++ ++ W+ G + G FP +YV+ I
Sbjct: 902 KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWF-GEVHGGRGWFPKSYVKII 954
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/333 (25%), Positives = 122/333 (36%), Gaps = 57/333 (17%)
Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214
L H +N P A S PP PP PP+ R +T +P +
Sbjct: 328 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 385
Query: 215 TSPARLGSQHSPGRTASL-NQRPRT----------HSGSSGGSGSR--ENSGSSSIGIPI 261
+ P + ++ PG+++ L ++RP G S SR E +GS S
Sbjct: 386 SEPRSI-FEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRS 444
Query: 262 AVPTPSP--PTIGPAAPGSAP--------------GSQY-GTMTRQISRHNSTTSSTSSG 304
PTPS P + P P P S Y ++ R + R S+ S S
Sbjct: 445 GAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDF 504
Query: 305 GYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIP--------MFDDSPP 356
RR ++P V GP + D P D+P F S P
Sbjct: 505 RKRR--------KSEPAV--GP---PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 551
Query: 357 PPPPPPVDYEDEEAAVVQYNDP--YADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEG 414
P D E + D A + P+ A+YD+ ELSF +G
Sbjct: 552 SSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKG 611
Query: 415 AIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
+Y+++K D WYEG + G+FP +YVE +
Sbjct: 612 DTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 413
P PP P Y + + N P P + +N E A+Y+YT +DEL E
Sbjct: 732 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 788
Query: 414 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 447
+I V++K DDGW+ G R G FPGNYV+ +
Sbjct: 789 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 50.8 bits (120), Expect = 2e-06
Identities = 82/312 (26%), Positives = 118/312 (37%), Gaps = 47/312 (15%)
Query: 172 SRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPG--RT 229
SR T P PP SG T P L P +PP P DY+ HS G
Sbjct: 429 SRLGEVTGSPSPPPRSGAPTPSSRAP--ALSPTRPPKKPLDYV-------QDHSSGVFNE 479
Query: 230 ASLNQRP------RTHSGSSGGSGSRENSGSS-SIGIPIAVPTPSPPTIGPAAPGSAPGS 282
ASL Q R S +S S R+ S ++G P + S P PGS
Sbjct: 480 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV-DLPGS 538
Query: 283 QYGTMTRQISRHNSTTSSTSSGGYRRTP-----SVTAQFSAQPHVNGGPLYSQNSIADSP 337
T+T+ + +S+ SS S R +P ++T + P G + A +
Sbjct: 539 ST-TLTKSFT--SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAV 595
Query: 338 TPPPPPPPDDIPMFDDSPPPPPPPPVD---YEDEE--------AAVVQYNDPYADGDPAW 386
++ F +D YE E + V+ P PA
Sbjct: 596 YDFKAQTSKELS-FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 654
Query: 387 APK----NYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLF 439
P I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+F
Sbjct: 655 PPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIF 713
Query: 440 PGNYVESIMHYT 451
P +YVE + T
Sbjct: 714 PVSYVEVVKKNT 725
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/333 (25%), Positives = 122/333 (36%), Gaps = 57/333 (17%)
Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214
L H +N P A S PP PP PP+ R +T +P +
Sbjct: 235 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 292
Query: 215 TSPARLGSQHSPGRTASL-NQRPRT----------HSGSSGGSGSR--ENSGSSSIGIPI 261
+ P + ++ PG+++ L ++RP G S SR E +GS S
Sbjct: 293 SEPRSI-FEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRS 351
Query: 262 AVPTPSP--PTIGPAAPGSAP--------------GSQY-GTMTRQISRHNSTTSSTSSG 304
PTPS P + P P P S Y ++ R + R S+ S S
Sbjct: 352 GAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDF 411
Query: 305 GYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIP--------MFDDSPP 356
RR ++P V GP + D P D+P F S P
Sbjct: 412 RKRR--------KSEPAV--GP---PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 458
Query: 357 PPPPPPVDYEDEEAAVVQYNDP--YADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEG 414
P D E + D A + P+ A+YD+ ELSF +G
Sbjct: 459 SSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKG 518
Query: 415 AIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
+Y+++K D WYEG + G+FP +YVE +
Sbjct: 519 DTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 551
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 413
P PP P Y + + N P P + +N E A+Y+YT +DEL E
Sbjct: 639 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 695
Query: 414 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 447
+I V++K DDGW+ G R G FPGNYV+ +
Sbjct: 696 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 50.8 bits (120), Expect = 2e-06
Identities = 82/312 (26%), Positives = 118/312 (37%), Gaps = 47/312 (15%)
Query: 172 SRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPG--RT 229
SR T P PP SG T P L P +PP P DY+ HS G
Sbjct: 336 SRLGEVTGSPSPPPRSGAPTPSSRAP--ALSPTRPPKKPLDYV-------QDHSSGVFNE 386
Query: 230 ASLNQRP------RTHSGSSGGSGSRENSGSS-SIGIPIAVPTPSPPTIGPAAPGSAPGS 282
ASL Q R S +S S R+ S ++G P + S P PGS
Sbjct: 387 ASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV-DLPGS 445
Query: 283 QYGTMTRQISRHNSTTSSTSSGGYRRTP-----SVTAQFSAQPHVNGGPLYSQNSIADSP 337
T+T+ + +S+ SS S R +P ++T + P G + A +
Sbjct: 446 ST-TLTKSFT--SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAV 502
Query: 338 TPPPPPPPDDIPMFDDSPPPPPPPPVD---YEDEE--------AAVVQYNDPYADGDPAW 386
++ F +D YE E + V+ P PA
Sbjct: 503 YDFKAQTSKELS-FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 561
Query: 387 APK----NYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLF 439
P I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+F
Sbjct: 562 PPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIF 620
Query: 440 PGNYVESIMHYT 451
P +YVE + T
Sbjct: 621 PVSYVEVVKKNT 632
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 60.8 bits (146), Expect = 2e-09
Identities = 26/52 (50%), Positives = 35/52 (67%)
Query: 394 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 445
+V+ +YDYT DDEL+F +G II V+ K D W++G N GLFP NYV+
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 47.0 bits (110), Expect = 4e-05
Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 1/61 (1%)
Query: 384 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 443
PA P E+ +A+Y Y + +L+F +G +I V KK+ D W+ G G+FP NY
Sbjct: 996 PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTGTVGDKAGVFPSNY 1054
Query: 444 V 444
V
Sbjct: 1055 V 1055
Score = 38.9 bits (89), Expect = 0.010
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 7/62 (11%)
Query: 389 KNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNY 443
K I +V+A YT ++L+ G +I + KKN GW+EG R G FP NY
Sbjct: 1075 KPEIAQVIA--SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132
Query: 444 VE 445
V+
Sbjct: 1133 VK 1134
Score = 33.9 bits (76), Expect = 0.31
Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 7/58 (12%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYV-------IKKNDDGWYEGVCNRVTGLFPGNYVESI 447
A+Y + DE++ G I+ V + + GW G TG FP NY E I
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804
Score = 33.9 bits (76), Expect = 0.31
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 13/159 (8%)
Query: 295 NSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADS----PTPPPPPPPDDIPM 350
+ST++ R TP+ A S++P + N+ AD PT P D
Sbjct: 818 DSTSAPAPKLALRETPAPLAVTSSEPST------TPNNWADFSSTWPTSTNEKPETDNWD 871
Query: 351 FDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIE--KVVAIYDYTKDKDDE 408
+ P P + +A + P +E + A+Y + KD+
Sbjct: 872 AWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNH 931
Query: 409 LSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
L+F + +I V+++ D W+ G G FP +YV+ I
Sbjct: 932 LNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLI 969
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 60.8 bits (146), Expect = 2e-09
Identities = 26/52 (50%), Positives = 35/52 (67%)
Query: 394 KVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 445
+V+ +YDYT DDEL+F +G II V+ K D W++G N GLFP NYV+
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVK 1210
Score = 47.0 bits (110), Expect = 4e-05
Identities = 23/61 (37%), Positives = 34/61 (55%), Gaps = 1/61 (1%)
Query: 384 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNY 443
PA P E+ +A+Y Y + +L+F +G +I V KK+ D W+ G G+FP NY
Sbjct: 996 PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGD-WWTGTVGDKAGVFPSNY 1054
Query: 444 V 444
V
Sbjct: 1055 V 1055
Score = 38.9 bits (89), Expect = 0.010
Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 7/62 (11%)
Query: 389 KNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVC-----NRVTGLFPGNY 443
K I +V+A YT ++L+ G +I + KKN GW+EG R G FP NY
Sbjct: 1075 KPEIAQVIA--SYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132
Query: 444 VE 445
V+
Sbjct: 1133 VK 1134
Score = 33.9 bits (76), Expect = 0.31
Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 7/58 (12%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYV-------IKKNDDGWYEGVCNRVTGLFPGNYVESI 447
A+Y + DE++ G I+ V + + GW G TG FP NY E I
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804
Score = 33.9 bits (76), Expect = 0.31
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 13/159 (8%)
Query: 295 NSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADS----PTPPPPPPPDDIPM 350
+ST++ R TP+ A S++P + N+ AD PT P D
Sbjct: 818 DSTSAPAPKLALRETPAPLAVTSSEPST------TPNNWADFSSTWPTSTNEKPETDNWD 871
Query: 351 FDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIE--KVVAIYDYTKDKDDE 408
+ P P + +A + P +E + A+Y + KD+
Sbjct: 872 AWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNH 931
Query: 409 LSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
L+F + +I V+++ D W+ G G FP +YV+ I
Sbjct: 932 LNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLI 969
>gi|27544941 myosin IF [Homo sapiens]
Length = 1098
Score = 60.5 bits (145), Expect = 3e-09
Identities = 55/215 (25%), Positives = 79/215 (36%), Gaps = 12/215 (5%)
Query: 244 GGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSS 303
GG G+R + S G +AV T+ + P S T +S +
Sbjct: 885 GGGGTRSVTFSRGFG-DLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPT 943
Query: 304 GGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPPPPV 363
P + P GGPL + PP PP P PP
Sbjct: 944 RAAPAPPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEH 1003
Query: 364 DYE-----DEEAAVVQYNDPYAD------GDPAWAPKNYIEKVVAIYDYTKDKDDELSFM 412
+ E D+ A +Q G P P+ + + A+Y Y DELSF
Sbjct: 1004 NTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFN 1063
Query: 413 EGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
+I ++ ++ GW++G + GLFPGNYVE I
Sbjct: 1064 VNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI 1098
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 59.3 bits (142), Expect = 7e-09
Identities = 44/147 (29%), Positives = 61/147 (41%), Gaps = 36/147 (24%)
Query: 335 DSPTPPPPPPP-------DDIPMFDDSPPPPPPPPV----DYEDEEAAVVQYNDPYADGD 383
D+ PP PP ++ P+++ P P P P DYED E + +GD
Sbjct: 337 DNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGD 396
Query: 384 ----------------------PAWAPKNYIE---KVVAIYDYTKDKDDELSFMEGAIIY 418
PA A + VA+YDY + DELSF +I
Sbjct: 397 YEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVIT 456
Query: 419 VIKKNDDGWYEGVCNRVTGLFPGNYVE 445
I+ D+GW+ G C+ GLFP NYV+
Sbjct: 457 DIEMVDEGWWRGRCHGHFGLFPANYVK 483
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 58.5 bits (140), Expect = 1e-08
Identities = 58/219 (26%), Positives = 72/219 (32%), Gaps = 34/219 (15%)
Query: 164 QPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGS- 222
+P+R P ++ PP P G G P E V+ P SPAR GS
Sbjct: 416 EPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRP----ASPARSGSP 471
Query: 223 ------------QHSP--GRTASLNQRPRTHSGSSGGSGSRENSGSSSI--GIPIAVPTP 266
QHS R L + R+ E SS + P
Sbjct: 472 APETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVP 531
Query: 267 SPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGP 326
S GP P AP + + T S G R +P Q A P +G
Sbjct: 532 SGSGHGPCTPPPAPANFEDV---------APTGSGEPGATRESPKANGQNQASPCSSGDD 582
Query: 327 LYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDY 365
+ + PP P PP P PPPPPPPP Y
Sbjct: 583 MEISDDDRGGSPPPAPTPPQQPP----PPPPPPPPPPPY 617
Score = 37.7 bits (86), Expect = 0.022
Identities = 49/214 (22%), Positives = 77/214 (35%), Gaps = 23/214 (10%)
Query: 161 GNNQPARTGTL---SRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSP 217
GN P T SR + P+ P S +GT PY T P + + Y +S
Sbjct: 238 GNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGT-----PY-TSRGSTPYSQDSAYSSST 291
Query: 218 ARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPG 277
+ + + R H +S S + S++I A S + +
Sbjct: 292 TSTSFKPRRSENSYQDAFSRRHFSASSAS----TTASTAIAATTAATASSSASSSSLSSS 347
Query: 278 SAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSP 337
S+ S + + S N S Y+R S + + + G P +++N+ P
Sbjct: 348 SSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAP-FAENTAERFP 406
Query: 338 T------PPPPPPPDDI---PMFDDSPPPPPPPP 362
PP P P D P ++PPP PP P
Sbjct: 407 PSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEP 440
Score = 32.3 bits (72), Expect = 0.90
Identities = 41/149 (27%), Positives = 53/149 (35%), Gaps = 30/149 (20%)
Query: 225 SPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGI-----PIAVPTPSPPTIGPAAPGSA 279
S ++S + + S SS S S +S SSS P A+P+ SPP P A
Sbjct: 1031 SDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPA 1090
Query: 280 PGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTP 339
P G TP + A P GP ++ S +P
Sbjct: 1091 P--------------VEVPVPERVAGSPVTP--LPEQEASPARPAGP--TEESPPSAPLR 1132
Query: 340 PPPP---PPDDIPMFDDSPPPP----PPP 361
PP P PP P D+ P P PPP
Sbjct: 1133 PPEPPAGPPAPAPRPDERPSSPIPLLPPP 1161
Score = 32.0 bits (71), Expect = 1.2
Identities = 33/154 (21%), Positives = 44/154 (28%), Gaps = 34/154 (22%)
Query: 215 TSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPA 274
TS + S S ++S + + S SS S E +P A P P +
Sbjct: 1030 TSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTP 1089
Query: 275 APGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIA 334
AP P V + + P PL Q +
Sbjct: 1090 APVEVP-------------------------------VPERVAGSPVT---PLPEQEASP 1115
Query: 335 DSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDE 368
P P P P+ PP PP P DE
Sbjct: 1116 ARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDE 1149
Score = 28.9 bits (63), Expect = 10.0
Identities = 10/12 (83%), Positives = 10/12 (83%)
Query: 355 PPPPPPPPVDYE 366
PPPPPPPP YE
Sbjct: 1405 PPPPPPPPRAYE 1416
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 58.5 bits (140), Expect = 1e-08
Identities = 44/138 (31%), Positives = 58/138 (42%), Gaps = 28/138 (20%)
Query: 338 TPPPPPP---------PDDIP----MFDDSPPPPPPP----------PVDYEDEEAAVVQ 374
TPPP P P D+P + +PP PPPP P AA
Sbjct: 367 TPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGM 426
Query: 375 YNDPYADGDPAWA---PKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV 431
P A A P+ VAIY YT K+DEL +G + V ++ DGW++G
Sbjct: 427 GPRPMAGSTDQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGT 486
Query: 432 CNRVT--GLFPGNYVESI 447
+ G+FPGNYV +
Sbjct: 487 SMHTSKIGVFPGNYVAPV 504
Score = 52.8 bits (125), Expect = 6e-07
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 13/97 (13%)
Query: 353 DSPPPPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFM 412
DS P PPP V+ + P E+ + Y + EL
Sbjct: 803 DSAVPIAPPPRQACSSLGPVLNESRPVV-----------CERHRVVVSYPPQSEAELELK 851
Query: 413 EGAIIYVIKKNDDGWYEGVCNR--VTGLFPGNYVESI 447
EG I++V KK +DGW++G R TGLFPG++VE+I
Sbjct: 852 EGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
Score = 45.1 bits (105), Expect = 1e-04
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
A+Y+Y + +L F +G II + ++ D+ WY G N + G FP N+V+ I
Sbjct: 141 ALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQII 191
Score = 38.9 bits (89), Expect = 0.010
Identities = 21/53 (39%), Positives = 33/53 (62%), Gaps = 4/53 (7%)
Query: 397 AIYDY-TKDKD---DELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 445
A+YD+ KDK+ D L F + ++ VI++ D+ W EG+ G+FP +YVE
Sbjct: 203 ALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVE 255
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 413
P PP P Y + + N P P + +N E A+Y+YT +DEL E
Sbjct: 400 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 456
Query: 414 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 447
+I V++K DDGW+ G R G FPGNYV+ +
Sbjct: 457 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 57.0 bits (136), Expect = 3e-08
Identities = 66/296 (22%), Positives = 102/296 (34%), Gaps = 55/296 (18%)
Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214
L H +N P A S PP PP PP+ R +T +P +
Sbjct: 68 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 125
Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273
+ P + ++ PG+++ L ++RP + SS S+S+ S P +GP
Sbjct: 126 SEPRSI-FEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP 184
Query: 274 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI 333
G S T ++ S+T+ T S
Sbjct: 185 PR-GLGDQSASRTSPGRVDLPGSSTTLTKS------------------------------ 213
Query: 334 ADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDP--YADGDPAWAPKNY 391
F S P P D E + D A + P+
Sbjct: 214 -----------------FTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE 256
Query: 392 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE +
Sbjct: 257 KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 312
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 413
P PP P Y + + N P P + +N E A+Y+YT +DEL E
Sbjct: 912 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 968
Query: 414 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 447
+I V++K DDGW+ G R G FPGNYV+ +
Sbjct: 969 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/51 (41%), Positives = 32/51 (62%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE +
Sbjct: 774 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824
Score = 42.4 bits (98), Expect = 9e-04
Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 4/71 (5%)
Query: 384 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLFP 440
P A I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+FP
Sbjct: 836 PPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIFP 894
Query: 441 GNYVESIMHYT 451
+YVE + T
Sbjct: 895 VSYVEVVKKNT 905
Score = 33.5 bits (75), Expect = 0.41
Identities = 38/165 (23%), Positives = 64/165 (38%), Gaps = 19/165 (11%)
Query: 156 LKAKHGNNQPARTGTLSRTNPPTQKPPS-PPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214
L H +N P S PP PP PP+ R +T +P +
Sbjct: 53 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 110
Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273
+ P + ++ PG+++ L ++RP + SS S+S+ S P +GP
Sbjct: 111 SEPRSI-FEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP 169
Query: 274 -----------AAPG--SAPGSQYGTMTRQISRHNSTTSSTSSGG 305
+PG PGS T+T+ + + ++ S + GG
Sbjct: 170 PRGLGDQSASRTSPGRVDLPGSS-TTLTKSFTSSSPSSPSRAKGG 213
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 413
P PP P Y + + N P P + +N E A+Y+YT +DEL E
Sbjct: 569 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 625
Query: 414 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 447
+I V++K DDGW+ G R G FPGNYV+ +
Sbjct: 626 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/51 (41%), Positives = 32/51 (62%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE +
Sbjct: 431 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 481
Score = 42.7 bits (99), Expect = 7e-04
Identities = 71/322 (22%), Positives = 117/322 (36%), Gaps = 78/322 (24%)
Query: 164 QPARTGTLSRTNPPTQKP------PSPPMSGRGTLGRNTPYKTLE-PVKPPTVPNDYMTS 216
+P ++ L PP +KP S + +L +++ ++LE P+ ++ +D+
Sbjct: 285 EPGKSSILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRK- 343
Query: 217 PARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAP 276
R S+ + G L + +S S R + SS + + + SP + A
Sbjct: 344 --RRKSEPAVGPPRGLGDQ-----SASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKD 396
Query: 277 GSAPGSQYGTMT---RQISRHNSTTSSTSSGGYRRTPSVTAQFSAQ-PHVNGGPLY---- 328
+P S T+T R R T + AQ S + G +Y
Sbjct: 397 RESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK 456
Query: 329 -SQN---------------SIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAV 372
QN S + TPP P + PPPP P +
Sbjct: 457 IDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP--------ARPPPPAQPGE-------- 500
Query: 373 VQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV- 431
I + +A Y++ D + ELS +G + ++K+ D WYEG
Sbjct: 501 -------------------IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 541
Query: 432 --CNRVTGLFPGNYVESIMHYT 451
NR G+FP +YVE + T
Sbjct: 542 PGTNR-QGIFPVSYVEVVKKNT 562
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 413
P PP P Y + + N P P + +N E A+Y+YT +DEL E
Sbjct: 552 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 608
Query: 414 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 447
+I V++K DDGW+ G R G FPGNYV+ +
Sbjct: 609 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 57.0 bits (136), Expect = 3e-08
Identities = 66/296 (22%), Positives = 102/296 (34%), Gaps = 55/296 (18%)
Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214
L H +N P A S PP PP PP+ R +T +P +
Sbjct: 220 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 277
Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273
+ P + ++ PG+++ L ++RP + SS S+S+ S P +GP
Sbjct: 278 SEPRSI-FEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP 336
Query: 274 AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI 333
G S T ++ S+T+ T S
Sbjct: 337 PR-GLGDQSASRTSPGRVDLPGSSTTLTKS------------------------------ 365
Query: 334 ADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDP--YADGDPAWAPKNY 391
F S P P D E + D A + P+
Sbjct: 366 -----------------FTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE 408
Query: 392 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE +
Sbjct: 409 KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 464
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 413
P PP P Y + + N P P + +N E A+Y+YT +DEL E
Sbjct: 1008 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 1064
Query: 414 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 447
+I V++K DDGW+ G R G FPGNYV+ +
Sbjct: 1065 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 51.6 bits (122), Expect = 1e-06
Identities = 21/51 (41%), Positives = 32/51 (62%)
Query: 397 AIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 447
A+YD+ ELSF +G +Y+++K D WYEG + G+FP +YVE +
Sbjct: 870 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
Score = 42.4 bits (98), Expect = 9e-04
Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 4/71 (5%)
Query: 384 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLFP 440
P A I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+FP
Sbjct: 932 PPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIFP 990
Query: 441 GNYVESIMHYT 451
+YVE + T
Sbjct: 991 VSYVEVVKKNT 1001
Score = 33.5 bits (75), Expect = 0.41
Identities = 38/165 (23%), Positives = 64/165 (38%), Gaps = 19/165 (11%)
Query: 156 LKAKHGNNQPARTGTLSRTNPPTQKPPS-PPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214
L H +N P S PP PP PP+ R +T +P +
Sbjct: 149 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 206
Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273
+ P + ++ PG+++ L ++RP + SS S+S+ S P +GP
Sbjct: 207 SEPRSI-FEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP 265
Query: 274 -----------AAPG--SAPGSQYGTMTRQISRHNSTTSSTSSGG 305
+PG PGS T+T+ + + ++ S + GG
Sbjct: 266 PRGLGDQSASRTSPGRVDLPGSS-TTLTKSFTSSSPSSPSRAKGG 309
Score = 28.9 bits (63), Expect = 10.0
Identities = 55/242 (22%), Positives = 81/242 (33%), Gaps = 46/242 (19%)
Query: 207 PTVPNDYMTSPARLGS----QH--SPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIP 260
P P+ Y + PA L S QH S T + Q ++ G++ S S +
Sbjct: 7 PFSPSAY-SLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT 65
Query: 261 IAVPTPSPPTIGPAAPGSAPGS----------QYGTMTRQISRHNS--------TTSSTS 302
+ + P P IGP P + Y TM +QI + T T
Sbjct: 66 V-IKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTY 124
Query: 303 SGGYRRTPSVTAQFSAQPHVNGGPLY------SQNSIADSPTPPPPPPPDDIPMFDDSPP 356
+ G P A PL S N+ D+ +P PPP
Sbjct: 125 NAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPP-----------HV 173
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAI 416
PPP PP+ D + DP D + + + +I++Y K L A
Sbjct: 174 PPPVPPLRPRDRSSTEKHDWDP---PDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPAS 230
Query: 417 IY 418
+Y
Sbjct: 231 LY 232
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/96 (35%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 357 PPPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYI---EKVVAIYDYTKDKDDELSFME 413
P PP P Y + + N P P + +N E A+Y+YT +DEL E
Sbjct: 574 PDPPIPHSYSSDRIHSLSSNKPQR---PVFTHENIQGGGEPFQALYNYTPRNEDELELRE 630
Query: 414 GAIIYVIKKNDDGWYEGVCNRVT--GLFPGNYVESI 447
+I V++K DDGW+ G R G FPGNYV+ +
Sbjct: 631 SDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
Score = 57.0 bits (136), Expect = 3e-08
Identities = 71/308 (23%), Positives = 110/308 (35%), Gaps = 32/308 (10%)
Query: 156 LKAKHGNNQP-ARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYM 214
L H +N P A S PP PP PP+ R +T +P +
Sbjct: 195 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDR--SSTEKHDWDPPDRKVDTRKFR 252
Query: 215 TSPARLGSQHSPGRTASL-NQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGP 273
+ P + ++ PG+++ L ++RP E + P P P
Sbjct: 253 SEPRSI-FEYEPGKSSILQHERPTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYV 311
Query: 274 AAPGSAPGSQ----YGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYS 329
S ++ ++ R + R S+ S S RR ++P V GP
Sbjct: 312 QDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR--------KSEPAV--GP--- 358
Query: 330 QNSIADSPTPPPPPPPDDIP--------MFDDSPPPPPPPPVDYEDEEAAVVQYNDP--Y 379
+ D P D+P F S P P D E + D
Sbjct: 359 PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRS 418
Query: 380 ADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLF 439
A + P+ A+YD+ ELSF +G +Y+++K D WYEG + G+F
Sbjct: 419 APRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIF 478
Query: 440 PGNYVESI 447
P +YVE +
Sbjct: 479 PISYVEKL 486
Score = 42.4 bits (98), Expect = 9e-04
Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 4/71 (5%)
Query: 384 PAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGV---CNRVTGLFP 440
P A I + +A Y++ D + ELS +G + ++K+ D WYEG NR G+FP
Sbjct: 498 PPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR-QGIFP 556
Query: 441 GNYVESIMHYT 451
+YVE + T
Sbjct: 557 VSYVEVVKKNT 567
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 57.8 bits (138), Expect = 2e-08
Identities = 28/50 (56%), Positives = 32/50 (64%)
Query: 396 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 445
VA+YDY DDE+SF II I+ DDGW+ GVC GLFP NYVE
Sbjct: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 57.8 bits (138), Expect = 2e-08
Identities = 28/50 (56%), Positives = 32/50 (64%)
Query: 396 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 445
VA+YDY DDE+SF II I+ DDGW+ GVC GLFP NYVE
Sbjct: 461 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
Length = 639
Score = 57.0 bits (136), Expect = 3e-08
Identities = 57/211 (27%), Positives = 77/211 (36%), Gaps = 46/211 (21%)
Query: 176 PPTQKPPSPPMS-GRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQ 234
PP +PP PPM+ G G + P PP + Y+ G T +
Sbjct: 422 PPWMQPPPPPMNQGPHPPGHHGP--------PPM--DQYL------------GSTPVGSG 459
Query: 235 RPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSA----------PGSQY 284
R H G G G P P PP GP P P S
Sbjct: 460 VYRLHQGK--GMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSM 517
Query: 285 GTMTRQISRHNSTTSSTSSGG-----YRRTPSVTAQFSAQPHVNGGPLYS------QNSI 333
+ T + N+TT++TS+G +++ + A P + G P Q +
Sbjct: 518 ASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPL 577
Query: 334 ADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD 364
PPPPPPP +PPPPPPPP+D
Sbjct: 578 PPGAPPPPPPPPPGSAGMMYAPPPPPPPPMD 608
Score = 49.3 bits (116), Expect = 7e-06
Identities = 59/245 (24%), Positives = 80/245 (32%), Gaps = 75/245 (30%)
Query: 140 PID-YTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPY 198
P+D Y VG GV L G P G + PP P PP S G P+
Sbjct: 446 PMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPS-----GPLPPW 500
Query: 199 -KTLEPVKPPTVPNDYMTSPARLGSQH------SPGRTASLNQRPRTHSGSSGGSGSREN 251
+ + PP P+ M S L Q + T S+ + + ++ G+ +
Sbjct: 501 QQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQM 560
Query: 252 SGS-SSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTP 310
G+ + + +P V P PP P P PGS
Sbjct: 561 QGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGS---------------------------- 592
Query: 311 SVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPD-------------DIPMFDDSPPP 357
G +Y +P PPPPPP D +P F P P
Sbjct: 593 -------------AGMMY-------APPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAP 632
Query: 358 PPPPP 362
PPPPP
Sbjct: 633 PPPPP 637
Score = 35.4 bits (80), Expect = 0.11
Identities = 55/212 (25%), Positives = 63/212 (29%), Gaps = 48/212 (22%)
Query: 165 PARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGS-Q 223
PA T S P PP S T P+ P + + P G
Sbjct: 335 PATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGP 394
Query: 224 HS-PGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGS---A 279
HS P SL +G GG + N P P P P GP PG
Sbjct: 395 HSFPHPLPSL-------TGGHGGHPMQHNPNGPPP--PWMQPPPPPMNQGPHPPGHHGPP 445
Query: 280 PGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSIADSPTP 339
P QY T SG YR G + + P P
Sbjct: 446 PMDQYLGST-----------PVGSGVYRLH-------------QGKGMMPPPPMGMMPPP 481
Query: 340 PPP-----PPPDDIPM-----FDDSPPPPPPP 361
PPP PPP P+ PPPPPPP
Sbjct: 482 PPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPP 513
>gi|55750053 atrophin-1 [Homo sapiens]
Length = 1190
Score = 56.2 bits (134), Expect = 6e-08
Identities = 58/213 (27%), Positives = 82/213 (38%), Gaps = 23/213 (10%)
Query: 165 PARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVP-------NDYMTSP 217
P + + P KPP+ P+ G G L P V P P N+ SP
Sbjct: 259 PISVSSSGASGAPPTKPPTTPVGG-GNLPSAPPPANFPHVTPNLPPPPALRPLNNASASP 317
Query: 218 ARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPG 277
LG+Q PG S P GG G + P ++P S + PA P
Sbjct: 318 PGLGAQPLPGHLPS----PHAMGQGMGGLPPGPEKGPTLAPSPHSLPPAS--SSAPAPPM 371
Query: 278 SAPGSQYGTMTRQISRHNSTTSSTSSG--GYRRTPSVTAQFSAQPHV---NGGPLYSQNS 332
P S + + S +S++SS++S + PS F + N P Y+Q S
Sbjct: 372 RFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPS 431
Query: 333 IAD----SPTPPPPPPPDDIPMFDDSPPPPPPP 361
+ S PPPPPP + ++ P P PP
Sbjct: 432 LPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPP 464
Score = 39.3 bits (90), Expect = 0.007
Identities = 63/265 (23%), Positives = 87/265 (32%), Gaps = 57/265 (21%)
Query: 160 HGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPAR 219
HGN+ P G + P + +LG PY P P +P +
Sbjct: 504 HGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPY----PPGPAHLPPPHSQVSYS 559
Query: 220 LGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIA-VPT------------- 265
+ P ++S N T GS S + G P VPT
Sbjct: 560 QAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIA 619
Query: 266 --------------PSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTS--STSSGGYRRT 309
P PP G AP +PG+ Y T T + S S + + GYR T
Sbjct: 620 TVASSPAGYKTASPPGPPPYGKRAP--SPGA-YKTATPPGYKPGSPPSFRTGTPPGYRGT 676
Query: 310 PSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPP------PPPV 363
+ +P G P P P PP P +P S PPPP PP
Sbjct: 677 SPPAGPGTFKP---GSPTVG-------PGPLPPAGPSGLP----SLPPPPAAPASGPPLS 722
Query: 364 DYEDEEAAVVQYNDPYADGDPAWAP 388
+ ++ +Y P + PA +P
Sbjct: 723 ATQIKQEPAEEYETPESPVPPARSP 747
Score = 38.5 bits (88), Expect = 0.013
Identities = 43/186 (23%), Positives = 61/186 (32%), Gaps = 22/186 (11%)
Query: 199 KTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIG 258
KT + + P P+D + R + ++Q R+ S S GS EN SS G
Sbjct: 91 KTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSG 150
Query: 259 I-----------PIAVPTPSPPTIGPAAPGSA--------PGSQYGTMTRQISRHNSTTS 299
+ P+ P+P PP P P ++ P + M SR
Sbjct: 151 LSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPP 210
Query: 300 STSSGGYRRTPSVTAQFSAQPHV---NGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPP 356
+ P T + P + GG S PPP P + S
Sbjct: 211 GAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGA 270
Query: 357 PPPPPP 362
PP PP
Sbjct: 271 PPTKPP 276
Score = 33.5 bits (75), Expect = 0.41
Identities = 50/203 (24%), Positives = 72/203 (35%), Gaps = 39/203 (19%)
Query: 178 TQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQH------SPGRTAS 231
+Q PP PP GR N P P T P H +
Sbjct: 439 SQGPPPPPPYGRLLANSNAHPG---PFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQ 495
Query: 232 LNQRPRTHSGSSG----GSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSA-------- 279
Q+ + H G+SG G+ G SS +PS ++ P PG A
Sbjct: 496 QQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQ 555
Query: 280 -PGSQYGTMTRQISRHNSTTSSTSSGGY---RRTPSVTAQFSAQPHVNGGPLYSQN---- 331
SQ G +S ++++SSTS G Y +PS Q + P + + +
Sbjct: 556 VSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLS 615
Query: 332 ----SIADSP------TPPPPPP 344
++A SP +PP PPP
Sbjct: 616 TVIATVASSPAGYKTASPPGPPP 638
Score = 29.3 bits (64), Expect = 7.7
Identities = 35/144 (24%), Positives = 56/144 (38%), Gaps = 20/144 (13%)
Query: 229 TASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMT 288
T +N++ R+ S S S E + +P P P+ + G + +
Sbjct: 64 TPKVNKQGRSEEISE--SESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDP 121
Query: 289 RQISRHNSTTSST--SSGGYRR---TPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPP 343
R I + N +TS + S G + S +Q A+P+ + PL+ PP P
Sbjct: 122 RDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPY-HPPPLF----------PPSPQ 170
Query: 344 PPDDIPMFDDS--PPPPPPPPVDY 365
PPD P ++ P P P Y
Sbjct: 171 PPDSTPRQPEASFEPHPSVTPTGY 194
>gi|55750041 atrophin-1 [Homo sapiens]
Length = 1190
Score = 56.2 bits (134), Expect = 6e-08
Identities = 58/213 (27%), Positives = 82/213 (38%), Gaps = 23/213 (10%)
Query: 165 PARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVP-------NDYMTSP 217
P + + P KPP+ P+ G G L P V P P N+ SP
Sbjct: 259 PISVSSSGASGAPPTKPPTTPVGG-GNLPSAPPPANFPHVTPNLPPPPALRPLNNASASP 317
Query: 218 ARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPG 277
LG+Q PG S P GG G + P ++P S + PA P
Sbjct: 318 PGLGAQPLPGHLPS----PHAMGQGMGGLPPGPEKGPTLAPSPHSLPPAS--SSAPAPPM 371
Query: 278 SAPGSQYGTMTRQISRHNSTTSSTSSG--GYRRTPSVTAQFSAQPHV---NGGPLYSQNS 332
P S + + S +S++SS++S + PS F + N P Y+Q S
Sbjct: 372 RFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPS 431
Query: 333 IAD----SPTPPPPPPPDDIPMFDDSPPPPPPP 361
+ S PPPPPP + ++ P P PP
Sbjct: 432 LPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPP 464
Score = 39.3 bits (90), Expect = 0.007
Identities = 63/265 (23%), Positives = 87/265 (32%), Gaps = 57/265 (21%)
Query: 160 HGNNQPARTGTLSRTNPPTQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPAR 219
HGN+ P G + P + +LG PY P P +P +
Sbjct: 504 HGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPY----PPGPAHLPPPHSQVSYS 559
Query: 220 LGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIA-VPT------------- 265
+ P ++S N T GS S + G P VPT
Sbjct: 560 QAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLSTVIA 619
Query: 266 --------------PSPPTIGPAAPGSAPGSQYGTMTRQISRHNSTTS--STSSGGYRRT 309
P PP G AP +PG+ Y T T + S S + + GYR T
Sbjct: 620 TVASSPAGYKTASPPGPPPYGKRAP--SPGA-YKTATPPGYKPGSPPSFRTGTPPGYRGT 676
Query: 310 PSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPPPPP------PPPV 363
+ +P G P P P PP P +P S PPPP PP
Sbjct: 677 SPPAGPGTFKP---GSPTVG-------PGPLPPAGPSGLP----SLPPPPAAPASGPPLS 722
Query: 364 DYEDEEAAVVQYNDPYADGDPAWAP 388
+ ++ +Y P + PA +P
Sbjct: 723 ATQIKQEPAEEYETPESPVPPARSP 747
Score = 38.5 bits (88), Expect = 0.013
Identities = 43/186 (23%), Positives = 61/186 (32%), Gaps = 22/186 (11%)
Query: 199 KTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIG 258
KT + + P P+D + R + ++Q R+ S S GS EN SS G
Sbjct: 91 KTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIYSPGSVENDSDSSSG 150
Query: 259 I-----------PIAVPTPSPPTIGPAAPGSA--------PGSQYGTMTRQISRHNSTTS 299
+ P+ P+P PP P P ++ P + M SR
Sbjct: 151 LSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSRMFQAPP 210
Query: 300 STSSGGYRRTPSVTAQFSAQPHV---NGGPLYSQNSIADSPTPPPPPPPDDIPMFDDSPP 356
+ P T + P + GG S PPP P + S
Sbjct: 211 GAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGA 270
Query: 357 PPPPPP 362
PP PP
Sbjct: 271 PPTKPP 276
Score = 33.5 bits (75), Expect = 0.41
Identities = 50/203 (24%), Positives = 72/203 (35%), Gaps = 39/203 (19%)
Query: 178 TQKPPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQH------SPGRTAS 231
+Q PP PP GR N P P T P H +
Sbjct: 439 SQGPPPPPPYGRLLANSNAHPG---PFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQ 495
Query: 232 LNQRPRTHSGSSG----GSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSA-------- 279
Q+ + H G+SG G+ G SS +PS ++ P PG A
Sbjct: 496 QQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQ 555
Query: 280 -PGSQYGTMTRQISRHNSTTSSTSSGGY---RRTPSVTAQFSAQPHVNGGPLYSQN---- 331
SQ G +S ++++SSTS G Y +PS Q + P + + +
Sbjct: 556 VSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLS 615
Query: 332 ----SIADSP------TPPPPPP 344
++A SP +PP PPP
Sbjct: 616 TVIATVASSPAGYKTASPPGPPP 638
Score = 29.3 bits (64), Expect = 7.7
Identities = 35/144 (24%), Positives = 56/144 (38%), Gaps = 20/144 (13%)
Query: 229 TASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPAAPGSAPGSQYGTMT 288
T +N++ R+ S S S E + +P P P+ + G + +
Sbjct: 64 TPKVNKQGRSEEISE--SESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDP 121
Query: 289 RQISRHNSTTSST--SSGGYRR---TPSVTAQFSAQPHVNGGPLYSQNSIADSPTPPPPP 343
R I + N +TS + S G + S +Q A+P+ + PL+ PP P
Sbjct: 122 RDIDQDNRSTSPSIYSPGSVENDSDSSSGLSQGPARPY-HPPPLF----------PPSPQ 170
Query: 344 PPDDIPMFDDS--PPPPPPPPVDY 365
PPD P ++ P P P Y
Sbjct: 171 PPDSTPRQPEASFEPHPSVTPTGY 194
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.130 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,989,924
Number of Sequences: 37866
Number of extensions: 1531483
Number of successful extensions: 29067
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 665
Number of HSP's successfully gapped in prelim test: 1119
Number of HSP's that attempted gapping in prelim test: 11733
Number of HSP's gapped (non-prelim): 9803
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.