BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|58330892 interferon-induced protein with tetratricopeptide repeats 1-like [Homo sapiens] (474 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|58330892 interferon-induced protein with tetratricopeptide re... 961 0.0 gi|116534937 interferon-induced protein with tetratricopeptide r... 652 0.0 gi|6912630 interferon-induced protein with tetratricopeptide rep... 520 e-147 gi|31542980 interferon-induced protein with tetratricopeptide re... 391 e-109 gi|72534658 interferon-induced protein with tetratricopeptide re... 391 e-109 gi|153082755 interferon-induced protein with tetratricopeptide r... 384 e-106 gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 51 3e-06 gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 51 3e-06 gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 49 1e-05 gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H... 42 0.001 gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H... 42 0.001 gi|17149828 NMDA receptor regulated 1 [Homo sapiens] 42 0.001 gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 42 0.002 gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Ho... 40 0.005 gi|54607135 translocase of outer mitochondrial membrane 70 homol... 39 0.013 gi|4885583 Rho-associated, coiled-coil containing protein kinase... 38 0.023 gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 37 0.039 gi|83415184 transmembrane and tetratricopeptide repeat containin... 37 0.039 gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 35 0.11 gi|118766328 transmembrane and tetratricopeptide repeat containi... 35 0.15 gi|118766330 transmembrane and tetratricopeptide repeat containi... 35 0.15 gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-... 35 0.19 gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 34 0.25 gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 33 0.43 gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 33 0.43 gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 33 0.43 gi|222418587 hypothetical protein LOC57495 [Homo sapiens] 33 0.56 gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 32 0.96 gi|74271826 glutamine synthetase [Homo sapiens] 32 0.96 gi|74271837 glutamine synthetase [Homo sapiens] 32 0.96 >gi|58330892 interferon-induced protein with tetratricopeptide repeats 1-like [Homo sapiens] Length = 474 Score = 961 bits (2483), Expect = 0.0 Identities = 474/474 (100%), Positives = 474/474 (100%) Query: 1 MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60 MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY Sbjct: 1 MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60 Query: 61 VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120 VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK Sbjct: 61 VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120 Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG Sbjct: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180 Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI Sbjct: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240 Query: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI Sbjct: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300 Query: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE Sbjct: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360 Query: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN Sbjct: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420 Query: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF 474 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF Sbjct: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF 474 >gi|116534937 interferon-induced protein with tetratricopeptide repeats 1 isoform 2 [Homo sapiens] Length = 478 Score = 652 bits (1681), Expect = 0.0 Identities = 319/469 (68%), Positives = 386/469 (82%) Query: 1 MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60 MS D ++DSL QLRCHFTW+L I+ E+PDLENR+ ++I+FLDTKY+VGIHNLLAY Sbjct: 1 MSTNGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAY 60 Query: 61 VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120 VKHLKGQNEEAL SLK+AE+L+Q+EH NQA++RSLVTWGNFAW+YYHMGRLAEAQTYLDK Sbjct: 61 VKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEAQTYLDK 120 Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180 VEN CKK +NP RYRMECPE+DCEEGWAL KCGGKNYERAK CFEK LE +PENPE + G Sbjct: 121 VENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAG 180 Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240 YAI+ YRLD F A+ +K FSL L++AVRLNPD+ YI+VLLALKLQDEGQEAEGEKYI Sbjct: 181 YAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYI 240 Query: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300 EEAL ++SSQ YVF+YAAKFYRRKGSVDKALELLK AL+ TPTS LHHQ+GLCY+AQMI Sbjct: 241 EEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMI 300 Query: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360 QIKEAT QPRGQ+RE +D++++ AI FE + K TFE+A++DLA Y E G+HRKAE Sbjct: 301 QIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAE 360 Query: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420 E+FQK L MK ++ Q+IH+HYGRFQE KS AI HYLK +KIE+ S +R+K +N Sbjct: 361 ENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSIN 420 Query: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAAD 469 +L+KL R + + +ES+SLLG ++KL+G +++AL YERALRLAAD Sbjct: 421 SLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAAD 469 >gi|6912630 interferon-induced protein with tetratricopeptide repeats 5 [Homo sapiens] Length = 482 Score = 520 bits (1339), Expect = e-147 Identities = 258/453 (56%), Positives = 337/453 (74%), Gaps = 1/453 (0%) Query: 14 LIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAYVKHLKGQNEEALV 73 L++L CHFTW LL E ++ ++E+ I ++++FL TK + ++NLLAYVKHLKGQN++AL Sbjct: 13 LLELECHFTWNLLKEDIDLFEVEDTIGQQLEFLTTKSRLALYNLLAYVKHLKGQNKDALE 72 Query: 74 SLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDKVENTCKKFANPSR 133 L++AE++IQ+EH+++ ++RSLVTWGN+AWVYYHM +L EAQ Y K+ N CKK ++PS Sbjct: 73 CLEQAEEIIQQEHSDKEEVRSLVTWGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSN 132 Query: 134 YRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNT 193 Y++ECPE DCE+GWAL K GGK Y++AK FEKALE P+NPEFN GYAITVYRLD + Sbjct: 133 YKLECPETDCEKGWALLKFGGKYYQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDD-SD 191 Query: 194 ASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYV 253 G K+FSL L++AV LNPD+ YI+V LALKLQD EAEGEKYIEE L ISSQ YV Sbjct: 192 REGSVKSFSLGPLRKAVTLNPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYV 251 Query: 254 FQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQ 313 +YAAKFYRRK S +KALELLK ALE TPTS+FLHHQMGLCYRAQMIQIK+AT+ +P+G+ Sbjct: 252 LRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGK 311 Query: 314 DRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFE 373 D+ VD L+ AI F+ + F AY DLA YAE G + AE+ F+K LR++ Sbjct: 312 DKLKVDELISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENIT 371 Query: 374 DQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIHQN 433 D K +IHYHYGRFQE H KS++ AI HYL+ LK++ S R KL +AL+KL+ + + N Sbjct: 372 DDHKHQIHYHYGRFQEFHRKSENTAIHHYLEALKVKDRSPLRTKLTSALKKLSTKRLCHN 431 Query: 434 VRVVESVSLLGLIHKLKGEVSDALLCYERALRL 466 V+S+S LG ++KL+GE A YE+A ++ Sbjct: 432 ALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKI 464 >gi|31542980 interferon-induced protein with tetratricopeptide repeats 3 [Homo sapiens] Length = 490 Score = 391 bits (1004), Expect = e-109 Identities = 217/470 (46%), Positives = 301/470 (64%), Gaps = 23/470 (4%) Query: 1 MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60 MSE + L E L QL+CHFTW L E DLE+R+ +I+FL+T++ ++NLLAY Sbjct: 1 MSEVTKNSL-EKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAY 59 Query: 61 VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120 +KHL G NE AL L++AE+LIQ+EHA+QA+IRSLVTWGN+AWVYYH+GRL++AQ Y+DK Sbjct: 60 IKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDK 119 Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180 V+ TCKKF+NP Y +E E+DCEEGW KCG ERAK CFEKALE P NPEF++G Sbjct: 120 VKQTCKKFSNP--YSIEYSELDCEEGWTQLKCG--RNERAKVCFEKALEEKPNNPEFSSG 175 Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240 AI +Y LD + K FS VLK+A+ L+PD+ Y++VLL LKLQ +EAEGE+++ Sbjct: 176 LAIAMYHLD-----NHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFV 230 Query: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300 EEAL Q V + AAKFYRRKG +DKA+EL + LE+TP + +L+HQ+G CY+A++ Sbjct: 231 EEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVR 290 Query: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360 Q++ + G ++E ++ L Q A+ K + AY DLAE Sbjct: 291 QMQNTGESEASG-NKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFL--------ET 341 Query: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420 E +Q ++ D KQ+ H Y Q+++GKS+D A+ H L+GL I K S +E++ + Sbjct: 342 ECYQTPFNKEV-PDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKD 400 Query: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERAL-RLAAD 469 + +++ + QN L GLIHK G++ A CYE+ L RL D Sbjct: 401 QPQNVSENLLPQN--APNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRD 448 >gi|72534658 interferon-induced protein with tetratricopeptide repeats 3 [Homo sapiens] Length = 490 Score = 391 bits (1004), Expect = e-109 Identities = 217/470 (46%), Positives = 301/470 (64%), Gaps = 23/470 (4%) Query: 1 MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60 MSE + L E L QL+CHFTW L E DLE+R+ +I+FL+T++ ++NLLAY Sbjct: 1 MSEVTKNSL-EKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAY 59 Query: 61 VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120 +KHL G NE AL L++AE+LIQ+EHA+QA+IRSLVTWGN+AWVYYH+GRL++AQ Y+DK Sbjct: 60 IKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDK 119 Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180 V+ TCKKF+NP Y +E E+DCEEGW KCG ERAK CFEKALE P NPEF++G Sbjct: 120 VKQTCKKFSNP--YSIEYSELDCEEGWTQLKCG--RNERAKVCFEKALEEKPNNPEFSSG 175 Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240 AI +Y LD + K FS VLK+A+ L+PD+ Y++VLL LKLQ +EAEGE+++ Sbjct: 176 LAIAMYHLD-----NHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFV 230 Query: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300 EEAL Q V + AAKFYRRKG +DKA+EL + LE+TP + +L+HQ+G CY+A++ Sbjct: 231 EEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVR 290 Query: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360 Q++ + G ++E ++ L Q A+ K + AY DLAE Sbjct: 291 QMQNTGESEASG-NKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFL--------ET 341 Query: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420 E +Q ++ D KQ+ H Y Q+++GKS+D A+ H L+GL I K S +E++ + Sbjct: 342 ECYQTPFNKEV-PDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKD 400 Query: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERAL-RLAAD 469 + +++ + QN L GLIHK G++ A CYE+ L RL D Sbjct: 401 QPQNVSENLLPQN--APNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRD 448 >gi|153082755 interferon-induced protein with tetratricopeptide repeats 2 [Homo sapiens] Length = 472 Score = 384 bits (985), Expect = e-106 Identities = 212/469 (45%), Positives = 297/469 (63%), Gaps = 17/469 (3%) Query: 1 MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60 MSE + L E SL QL+CHFTW L+ + D E++++ +F + ++ + NLLAY Sbjct: 1 MSENNKNSL-ESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAY 59 Query: 61 VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120 +KHLKGQNE AL L+KAE+LIQ+EHA+QA+IRSLVTWGN+AWVYYHMGRL++ Q Y+DK Sbjct: 60 LKHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDK 119 Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180 V++ C+KF++P YR+E PE+DCEEGW KCGG ERAK CFEKALE P+NPEF +G Sbjct: 120 VKHVCEKFSSP--YRIESPELDCEEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSG 177 Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKL---QDEG-QEAEG 236 AI YRLD + + ++ L++A+RLNPD+ Y++VLLALKL ++EG +E EG Sbjct: 178 LAIASYRLDNWPPSQN-----AIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEG 232 Query: 237 EKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYR 296 EK +EEAL V + AAKFYRRK DKA+ELLK ALE P +A+LH Q+G CYR Sbjct: 233 EKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYR 292 Query: 297 AQMIQIKEATNWQPRGQ-DRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGH 355 A++ Q+ N + G + + L+ A+ +K LA +A Sbjct: 293 AKVFQV---MNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQ 349 Query: 356 HRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSR 415 + AE +FQK K KQ +H YG FQ + K +DKAI H+++G+KI + S + Sbjct: 350 YEDAEYYFQKEF-SKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREK 408 Query: 416 EKLLNALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERAL 464 EK+ + L+K+AK + +N E++ +L + +L ++ A ER L Sbjct: 409 EKMKDKLQKIAKMRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGL 457 >gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] Length = 1036 Score = 50.8 bits (120), Expect = 3e-06 Identities = 85/401 (21%), Positives = 141/401 (35%), Gaps = 110/401 (27%) Query: 111 LAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEG 170 LA A +E + + + +Y + V + G L G E AK C+ KA+E Sbjct: 119 LAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALG--RLEEAKACYLKAIET 176 Query: 171 NPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPD--DVYIRVLLALKLQ 228 P +A+ L A G ++H ++AV L+P+ D YI Sbjct: 177 QPN-------FAVAWSNLGCVFNAQGEIW-LAIHHFEKAVTLDPNFLDAYIN-------- 220 Query: 229 DEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLH 288 L ++ +A +F A Y R AL +P A +H Sbjct: 221 ---------------LGNVLKEARIFDRAVAAYLR-------------ALSLSPNHAVVH 252 Query: 289 HQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAE 348 + Y Q L+ LAI + + I L+ F AY +LA Sbjct: 253 GNLACVYYEQ---------------------GLIDLAIDTYRRAIELQPHFPDAYCNLAN 291 Query: 349 TYAEIGHHRKAEEHFQKGLRM-------------------------KIFEDQLK-----Q 378 E G +AE+ + LR+ +++ L+ Sbjct: 292 ALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA 351 Query: 379 EIHYHYGRFQEHHGKSQDKAITHYLKGLKIE-KMSHSREKLLNALEKLA---------KR 428 H + + GK Q+ A+ HY + ++I + + + N L+++ R Sbjct: 352 AAHSNLASVLQQQGKLQE-ALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 410 Query: 429 CIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAAD 469 I N ++ S L IHK G + +A+ Y AL+L D Sbjct: 411 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451 >gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] Length = 1046 Score = 50.8 bits (120), Expect = 3e-06 Identities = 85/401 (21%), Positives = 141/401 (35%), Gaps = 110/401 (27%) Query: 111 LAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEG 170 LA A +E + + + +Y + V + G L G E AK C+ KA+E Sbjct: 129 LAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALG--RLEEAKACYLKAIET 186 Query: 171 NPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPD--DVYIRVLLALKLQ 228 P +A+ L A G ++H ++AV L+P+ D YI Sbjct: 187 QPN-------FAVAWSNLGCVFNAQGEIW-LAIHHFEKAVTLDPNFLDAYIN-------- 230 Query: 229 DEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLH 288 L ++ +A +F A Y R AL +P A +H Sbjct: 231 ---------------LGNVLKEARIFDRAVAAYLR-------------ALSLSPNHAVVH 262 Query: 289 HQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAE 348 + Y Q L+ LAI + + I L+ F AY +LA Sbjct: 263 GNLACVYYEQ---------------------GLIDLAIDTYRRAIELQPHFPDAYCNLAN 301 Query: 349 TYAEIGHHRKAEEHFQKGLRM-------------------------KIFEDQLK-----Q 378 E G +AE+ + LR+ +++ L+ Sbjct: 302 ALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA 361 Query: 379 EIHYHYGRFQEHHGKSQDKAITHYLKGLKIE-KMSHSREKLLNALEKLA---------KR 428 H + + GK Q+ A+ HY + ++I + + + N L+++ R Sbjct: 362 AAHSNLASVLQQQGKLQE-ALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 420 Query: 429 CIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAAD 469 I N ++ S L IHK G + +A+ Y AL+L D Sbjct: 421 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461 >gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo sapiens] Length = 860 Score = 48.9 bits (115), Expect = 1e-05 Identities = 67/276 (24%), Positives = 107/276 (38%), Gaps = 30/276 (10%) Query: 119 DKVENTCKKFANPSRYRMECPEVDCEEGWALAKC--GGKNYERAKTCFEKALEGNPENPE 176 +K+ + K A R+ E A+A G Y+ A F L+ P+ Sbjct: 119 EKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVS 178 Query: 177 FNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEG 236 G I K +N +L L R + L PD + A L G+ Sbjct: 179 AIYGRGIAY---GKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGR---- 231 Query: 237 EKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYR 296 I EA+ ++ +A Q +A+ YR +G++ E A E S L+ + Sbjct: 232 ---INEAVNDLT-KAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIA-- 285 Query: 297 AQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH 356 + + + RG L++ AI F++ + K F AY L + Y E+G+ Sbjct: 286 ----MLYKGLTFFHRG--------LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNF 333 Query: 357 RKAEEHFQKGLRMK---IFEDQLKQEIHYHYGRFQE 389 A E FQK L + + QL+ + YH+G QE Sbjct: 334 EAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQE 369 >gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo sapiens] Length = 631 Score = 42.0 bits (97), Expect = 0.001 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 9/109 (8%) Query: 102 AWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGK-----N 156 AW + R+ + LDK ++T + + S + VD ++ L + G K Sbjct: 92 AWAKLDVDRILDE---LDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGK 148 Query: 157 YERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTA-SGRNKAFSLH 204 Y+ A C+ K ++ +P NP T A +RL KF A S N A +L+ Sbjct: 149 YDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALN 197 >gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo sapiens] Length = 665 Score = 42.0 bits (97), Expect = 0.001 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 9/109 (8%) Query: 102 AWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGK-----N 156 AW + R+ + LDK ++T + + S + VD ++ L + G K Sbjct: 92 AWAKLDVDRILDE---LDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGK 148 Query: 157 YERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTA-SGRNKAFSLH 204 Y+ A C+ K ++ +P NP T A +RL KF A S N A +L+ Sbjct: 149 YDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALN 197 >gi|17149828 NMDA receptor regulated 1 [Homo sapiens] Length = 866 Score = 42.0 bits (97), Expect = 0.001 Identities = 29/91 (31%), Positives = 41/91 (45%), Gaps = 2/91 (2%) Query: 252 YVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPR 311 +V Y A+ Y + G ALE + A+E+TPT L Y+ IKEA W Sbjct: 375 WVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYK-HAGNIKEAARWMDE 433 Query: 312 GQDRETVDRLVQLAICKFE-KTIMLKRTFEM 341 Q +T DR + K+ K ++K EM Sbjct: 434 AQALDTADRFINSKCAKYMLKANLIKEAEEM 464 Score = 33.5 bits (75), Expect = 0.43 Identities = 40/162 (24%), Positives = 66/162 (40%), Gaps = 18/162 (11%) Query: 158 ERAKTCFEKALEGNPEN---PEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRL-N 213 E+ K C +K L N P FNT ++Y+ DK A ++ RL N Sbjct: 304 EKFKECLDKFLRMNFSKGCPPVFNT--LRSLYK-DKEKVAIIEELVVGYETSLKSCRLFN 360 Query: 214 PDD----------VYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRR 263 P+D ++++ LA GQ + +YI A+ S + +F AK Y+ Sbjct: 361 PNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKH 420 Query: 264 KGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEA 305 G++ +A + A F++ + Y + IKEA Sbjct: 421 AGNIKEAARWMDEAQALDTADRFINSKCAK-YMLKANLIKEA 461 >gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo sapiens] Length = 807 Score = 41.6 bits (96), Expect = 0.002 Identities = 41/153 (26%), Positives = 68/153 (44%), Gaps = 18/153 (11%) Query: 240 IEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQM 299 I EA+ ++ +A Q +A+ YR +G++ E A E S L+ + Sbjct: 179 INEAVNDLT-KAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIA----- 232 Query: 300 IQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKA 359 + + + RG L++ AI F++ + K F AY L + Y E+G+ A Sbjct: 233 -MLYKGLTFFHRG--------LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAA 283 Query: 360 EEHFQKGLRMK---IFEDQLKQEIHYHYGRFQE 389 E FQK L + + QL+ + YH+G QE Sbjct: 284 TESFQKALLLNQNHVQTLQLRGMMLYHHGSLQE 316 >gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Homo sapiens] Length = 864 Score = 40.0 bits (92), Expect = 0.005 Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 2/91 (2%) Query: 252 YVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPR 311 +V + A+ + + G AL+ + A+ +TPT L + Y+ + +KEA W Sbjct: 375 WVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYK-HIGNLKEAAKWMDE 433 Query: 312 GQDRETVDRLVQLAICKFE-KTIMLKRTFEM 341 Q +T DR + K+ + M+K EM Sbjct: 434 AQSLDTADRFINSKCAKYMLRANMIKEAEEM 464 Score = 29.3 bits (64), Expect = 8.1 Identities = 17/58 (29%), Positives = 28/58 (48%), Gaps = 5/58 (8%) Query: 353 IGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEK 410 +G +A E +KGLR + +K + +H + K D+AI Y LK++K Sbjct: 59 LGKKEEAYEFVRKGLR-----NDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDK 111 Score = 29.3 bits (64), Expect = 8.1 Identities = 21/89 (23%), Positives = 39/89 (43%), Gaps = 1/89 (1%) Query: 217 VYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKM 276 ++++ LA GQ + YI A+ S + +F AK Y+ G++ +A + + Sbjct: 374 LWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWMDE 433 Query: 277 ALETTPTSAFLHHQMGLCYRAQMIQIKEA 305 A F++ + Y + IKEA Sbjct: 434 AQSLDTADRFINSKCAK-YMLRANMIKEA 461 >gi|54607135 translocase of outer mitochondrial membrane 70 homolog A [Homo sapiens] Length = 608 Score = 38.5 bits (88), Expect = 0.013 Identities = 41/195 (21%), Positives = 81/195 (41%), Gaps = 13/195 (6%) Query: 104 VYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCG--GKNYERAK 161 VY+H G+L + LD+VE F R R E ++ +AL + G N + + Sbjct: 403 VYHHRGQL---KILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQ 459 Query: 162 TCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDV--YI 219 + E + P GYA+ L ++ + + + L PD+ Y+ Sbjct: 460 AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYD-----KCIDLEPDNATTYV 514 Query: 220 RVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALE 279 L L+LQ + G + I +A+ + + ++ ++G+++KA+++ A+ Sbjct: 515 HKGL-LQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAIN 573 Query: 280 TTPTSAFLHHQMGLC 294 + + H LC Sbjct: 574 LAKSEMEMAHLYSLC 588 >gi|4885583 Rho-associated, coiled-coil containing protein kinase 1 [Homo sapiens] Length = 1354 Score = 37.7 bits (86), Expect = 0.023 Identities = 40/175 (22%), Positives = 77/175 (44%), Gaps = 11/175 (6%) Query: 298 QMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHR 357 Q+ I EA + RG D E + L E+ LK E + E + H Sbjct: 605 QLQAILEAER-RDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSE 663 Query: 358 KAEEHFQKGL--RMKIFEDQLKQEIHYHY---GRFQEHHGKSQD-KAITHYLKGLKIEKM 411 K + + + L ++K + +L+QE++ H R + H ++ K++ K+++ Sbjct: 664 KEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEE 723 Query: 412 SHSREKLLNALEKLAKRCIHQNVRVVESVS----LLGLIHKLKGEVSDALLCYER 462 +REK N + ++ K+C +V + +S L G +++ EV + L E+ Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQ 778 >gi|7661950 SH2 domain binding protein 1 [Homo sapiens] Length = 1173 Score = 37.0 bits (84), Expect = 0.039 Identities = 67/255 (26%), Positives = 96/255 (37%), Gaps = 46/255 (18%) Query: 146 GWALAKCGGKNYERAKTCFEKALEGNPENP-EFNTGYAITVYRLDKFNTASGRNKAFSLH 204 G A K+Y A ++KAL NP P E G +L+K A AFS Sbjct: 168 GKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKA---RLAFS-- 222 Query: 205 VLKRAVRLNPDDVYIRVLLALKLQDEGQEAE----GEKYIEEALTSISSQAYVFQYAAKF 260 RA+ LN V V LA+ L+ +EA+ G + + A T S V + A Sbjct: 223 ---RALELNSKCVGALVGLAV-LELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANH 278 Query: 261 YRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDR 320 + K K L A T A Q CY Q+ + + Q E D+ Sbjct: 279 FFFKKDYSKVQHLALHAFHNTEVEAM---QAESCY-----QLARSFHVQ------EDYDQ 324 Query: 321 LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLR--------MKIF 372 Q ++ T +F + + L + Y G A + F+K L+ MKI Sbjct: 325 AFQY---YYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKIL 381 Query: 373 -------EDQLKQEI 380 EDQ K++I Sbjct: 382 GSLYAASEDQEKRDI 396 >gi|83415184 transmembrane and tetratricopeptide repeat containing 1 [Homo sapiens] Length = 774 Score = 37.0 bits (84), Expect = 0.039 Identities = 69/335 (20%), Positives = 139/335 (41%), Gaps = 37/335 (11%) Query: 160 AKTCFEKALEGNPENPE--FNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDV 217 AK +++AL+ +P++ FN G + S K ++ +LK +++ P+ Sbjct: 425 AKMYYQRALQLHPQHNRALFNLGNLLK----------SQEKKEEAITLLKDSIKYGPEFA 474 Query: 218 YIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMA 277 LA L ++ + E E+ + + + + + F G +KA+ + A Sbjct: 475 DAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQA 534 Query: 278 LETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPR----GQDRETVDRLVQL--------- 324 ++ +P+ +G YR+ + + A W R E + L L Sbjct: 535 IKLSPSHHVAMVNLGRLYRS-LGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEE 593 Query: 325 AICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHY 384 A+ +++ L+ + + LA+ A +G ++AE+ + + + + + Y Sbjct: 594 ALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIY 653 Query: 385 GRFQEHHGKSQ---DKAITHYLKGLKI------EKMSHSREK-LLNALEKLAKRCIHQNV 434 + QE+H K+ DKA+ K K+ K + RE+ LL+ + + + N Sbjct: 654 SK-QENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNP 712 Query: 435 RVVESVSLLGLIHKLKGEVSDALLCYERALRLAAD 469 ++ +G I +KG+ A YERAL+L D Sbjct: 713 DQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPD 747 >gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] Length = 1564 Score = 35.4 bits (80), Expect = 0.11 Identities = 43/196 (21%), Positives = 82/196 (41%), Gaps = 31/196 (15%) Query: 240 IEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQM 299 ++E+ S ++ + K +R K +V + LK+ ++ S +Q LC + Sbjct: 299 LKESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALKI-VDNLGASGNSLYQRNLCLHLKA 357 Query: 300 IQIKEATNWQPRGQDRETVDRLVQ------LAICK---------FEKTIMLKRTFEMAYV 344 + + +++ + T+D++ L + K F++ + +Y Sbjct: 358 EALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYP 417 Query: 345 DLAETYA--EIGHHRK-----AEEHFQKGLRMKIFEDQLKQEIHYHYGR----FQEHHGK 393 DLAE +A + H K AE+ FQ+ L +D E HY G E K Sbjct: 418 DLAEVHALEALIHFTKKDYLQAEKCFQRALE----KDTEVAEYHYQLGLTYWFMGEETRK 473 Query: 394 SQDKAITHYLKGLKIE 409 + KA+TH+LK +++ Sbjct: 474 DKTKALTHFLKAARLD 489 Score = 33.5 bits (75), Expect = 0.43 Identities = 23/75 (30%), Positives = 36/75 (48%) Query: 221 VLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALET 280 VL +L +++G E K +E+ L+S A V A + K +A + + ALE Sbjct: 390 VLKSLAYRNKGSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEK 449 Query: 281 TPTSAFLHHQMGLCY 295 A H+Q+GL Y Sbjct: 450 DTEVAEYHYQLGLTY 464 Score = 30.4 bits (67), Expect = 3.7 Identities = 18/55 (32%), Positives = 32/55 (58%), Gaps = 2/55 (3%) Query: 155 KNYERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRA 209 K+Y +A+ CF++ALE + E E++ +T + + + T + KA + H LK A Sbjct: 434 KDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGE-ETRKDKTKALT-HFLKAA 486 >gi|118766328 transmembrane and tetratricopeptide repeat containing 4 isoform 2 [Homo sapiens] Length = 741 Score = 35.0 bits (79), Expect = 0.15 Identities = 63/268 (23%), Positives = 106/268 (39%), Gaps = 30/268 (11%) Query: 38 RIWEEIQFLDTKYNVGIHNLLAYVKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVT 97 R + E L+ KY ++NL LK +NE L++AE+L+ Q D + Sbjct: 503 RYYREAVRLNPKYVHAMNNL---GNILKERNE-----LQEAEELLSLAVQIQPDFAA--- 551 Query: 98 WGNFAWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNY 157 AW+ L Q L + E + + ++R + P DC + Sbjct: 552 ----AWM-----NLGIVQNSLKRFEAAEQSYRTAIKHRRKYP--DCYYNLGRLYADLNRH 600 Query: 158 ERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDV 217 A + A PE+ + + + LD NT N A + V + A+ L P+D Sbjct: 601 VDALNAWRNATVLKPEH---SLAWNNMIILLD--NTG---NLAQAEAVGREALELIPNDH 652 Query: 218 YIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMA 277 + LA L + E E +A+ + + A A Y R G +D A + +++ Sbjct: 653 SLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEIS 712 Query: 278 LETTPTSAFLHHQMGLCYRAQMIQIKEA 305 L+ PT++ GL R + K+A Sbjct: 713 LQLDPTASGTKENYGLLRRKLELMQKKA 740 >gi|118766330 transmembrane and tetratricopeptide repeat containing 4 isoform 1 [Homo sapiens] Length = 760 Score = 35.0 bits (79), Expect = 0.15 Identities = 63/268 (23%), Positives = 106/268 (39%), Gaps = 30/268 (11%) Query: 38 RIWEEIQFLDTKYNVGIHNLLAYVKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVT 97 R + E L+ KY ++NL LK +NE L++AE+L+ Q D + Sbjct: 522 RYYREAVRLNPKYVHAMNNL---GNILKERNE-----LQEAEELLSLAVQIQPDFAA--- 570 Query: 98 WGNFAWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNY 157 AW+ L Q L + E + + ++R + P DC + Sbjct: 571 ----AWM-----NLGIVQNSLKRFEAAEQSYRTAIKHRRKYP--DCYYNLGRLYADLNRH 619 Query: 158 ERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDV 217 A + A PE+ + + + LD NT N A + V + A+ L P+D Sbjct: 620 VDALNAWRNATVLKPEH---SLAWNNMIILLD--NTG---NLAQAEAVGREALELIPNDH 671 Query: 218 YIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMA 277 + LA L + E E +A+ + + A A Y R G +D A + +++ Sbjct: 672 SLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEIS 731 Query: 278 LETTPTSAFLHHQMGLCYRAQMIQIKEA 305 L+ PT++ GL R + K+A Sbjct: 732 LQLDPTASGTKENYGLLRRKLELMQKKA 759 >gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta [Homo sapiens] Length = 304 Score = 34.7 bits (78), Expect = 0.19 Identities = 25/102 (24%), Positives = 47/102 (46%), Gaps = 8/102 (7%) Query: 104 VYYHMGRLAEAQT--YLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAK 161 VYY A+++ Y D +++ K A S+Y + LA +E A Sbjct: 120 VYYCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGRM------GLALTALNKFEEAV 173 Query: 162 TCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSL 203 T ++KAL+ +PEN + + I +L + ++ +G +F + Sbjct: 174 TSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTGTGLSFDM 215 >gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] Length = 519 Score = 34.3 bits (77), Expect = 0.25 Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 2/100 (2%) Query: 196 GRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQ 255 G++KA ++ V A +LN D I L + Q + + + AL +++ + Sbjct: 115 GKHKA-AIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNAL-NLNRHDLTYI 172 Query: 256 YAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCY 295 K + +G +DKA+E+ K A+E +P + L +GL Y Sbjct: 173 MLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLY 212 Score = 32.3 bits (72), Expect = 0.96 Identities = 21/94 (22%), Positives = 40/94 (42%) Query: 202 SLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFY 261 ++ V K+AV +P++ + L L G + +++ ALT + A Sbjct: 187 AIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMM 246 Query: 262 RRKGSVDKALELLKMALETTPTSAFLHHQMGLCY 295 + G D AL ++ P S L + +G+C+ Sbjct: 247 QTHGDFDVALTKYRVVACAVPESPPLWNNIGMCF 280 >gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] Length = 1614 Score = 33.5 bits (75), Expect = 0.43 Identities = 51/224 (22%), Positives = 85/224 (37%), Gaps = 50/224 (22%) Query: 261 YRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDR 320 Y G ALE K A + T+ L H +C+ ++ + +EA N+ Sbjct: 1280 YVELGQYGFALEDFKQAALISRTNGSLCHATAMCHH-RINEFEEAVNF------------ 1326 Query: 321 LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH---RKAEEHFQKGLRMKIFEDQLK 377 F + + F AYV +Y E GH ++A++ F K L I +K Sbjct: 1327 --------FTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALH--INPAYIK 1376 Query: 378 QEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIH------ 431 I + Y + GK Q KA H+ + + ++ A E A C+ Sbjct: 1377 ARISFGYN--LQAQGKFQ-KAWNHFTIAIDTDPKNYL------AYEGRAVVCLQMGNNFA 1427 Query: 432 --QNVRVVESVSLL-------GLIHKLKGEVSDALLCYERALRL 466 Q++ +S G+IH+ G +A+ Y+ A+ L Sbjct: 1428 AMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471 Score = 29.6 bits (65), Expect = 6.2 Identities = 31/161 (19%), Positives = 64/161 (39%), Gaps = 22/161 (13%) Query: 208 RAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSV 267 +A+ +NP + R+ LQ +G+ + + A+ + ++ A + G+ Sbjct: 1366 KALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNN 1425 Query: 268 DKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAIC 327 A++ + A++ + T+ FL TN RG E + Q A+ Sbjct: 1426 FAAMQDINAAMKISTTAEFL------------------TN---RGVIHEFMGHK-QNAMK 1463 Query: 328 KFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLR 368 ++ I L + +AY + Y +A ++F K L+ Sbjct: 1464 DYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504 Score = 29.3 bits (64), Expect = 8.1 Identities = 34/144 (23%), Positives = 60/144 (41%), Gaps = 13/144 (9%) Query: 155 KNYERAKTCFEKALEGNPENPEFNTGYAITVYR-LDKFNTASGRNKAFSLHVLKRAVRLN 213 K YE + + + P F +YR L K +A ++ L+R + L Sbjct: 896 KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA--------MNDLQRVILLE 947 Query: 214 PD--DVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKAL 271 P + Y L QD+ EA + +++AY+ + A+ YR K + A+ Sbjct: 948 PLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK--AEIYRGKKDITLAI 1005 Query: 272 ELLKMALETTPTSAFLHHQMGLCY 295 A+++TPT A ++ + G Y Sbjct: 1006 LNYTQAIKSTPTDADIYFRRGEMY 1029 >gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] Length = 1614 Score = 33.5 bits (75), Expect = 0.43 Identities = 51/224 (22%), Positives = 85/224 (37%), Gaps = 50/224 (22%) Query: 261 YRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDR 320 Y G ALE K A + T+ L H +C+ ++ + +EA N+ Sbjct: 1280 YVELGQYGFALEDFKQAALISRTNGSLCHATAMCHH-RINEFEEAVNF------------ 1326 Query: 321 LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH---RKAEEHFQKGLRMKIFEDQLK 377 F + + F AYV +Y E GH ++A++ F K L I +K Sbjct: 1327 --------FTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALH--INPAYIK 1376 Query: 378 QEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIH------ 431 I + Y + GK Q KA H+ + + ++ A E A C+ Sbjct: 1377 ARISFGYN--LQAQGKFQ-KAWNHFTIAIDTDPKNYL------AYEGRAVVCLQMGNNFA 1427 Query: 432 --QNVRVVESVSLL-------GLIHKLKGEVSDALLCYERALRL 466 Q++ +S G+IH+ G +A+ Y+ A+ L Sbjct: 1428 AMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471 Score = 29.6 bits (65), Expect = 6.2 Identities = 31/161 (19%), Positives = 64/161 (39%), Gaps = 22/161 (13%) Query: 208 RAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSV 267 +A+ +NP + R+ LQ +G+ + + A+ + ++ A + G+ Sbjct: 1366 KALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNN 1425 Query: 268 DKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAIC 327 A++ + A++ + T+ FL TN RG E + Q A+ Sbjct: 1426 FAAMQDINAAMKISTTAEFL------------------TN---RGVIHEFMGHK-QNAMK 1463 Query: 328 KFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLR 368 ++ I L + +AY + Y +A ++F K L+ Sbjct: 1464 DYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504 Score = 29.3 bits (64), Expect = 8.1 Identities = 34/144 (23%), Positives = 60/144 (41%), Gaps = 13/144 (9%) Query: 155 KNYERAKTCFEKALEGNPENPEFNTGYAITVYR-LDKFNTASGRNKAFSLHVLKRAVRLN 213 K YE + + + P F +YR L K +A ++ L+R + L Sbjct: 896 KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA--------MNDLQRVILLE 947 Query: 214 PD--DVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKAL 271 P + Y L QD+ EA + +++AY+ + A+ YR K + A+ Sbjct: 948 PLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK--AEIYRGKKDITLAI 1005 Query: 272 ELLKMALETTPTSAFLHHQMGLCY 295 A+++TPT A ++ + G Y Sbjct: 1006 LNYTQAIKSTPTDADIYFRRGEMY 1029 >gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo sapiens] Length = 1614 Score = 33.5 bits (75), Expect = 0.43 Identities = 51/224 (22%), Positives = 85/224 (37%), Gaps = 50/224 (22%) Query: 261 YRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDR 320 Y G ALE K A + T+ L H +C+ ++ + +EA N+ Sbjct: 1280 YVELGQYGFALEDFKQAALISRTNGSLCHATAMCHH-RINEFEEAVNF------------ 1326 Query: 321 LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH---RKAEEHFQKGLRMKIFEDQLK 377 F + + F AYV +Y E GH ++A++ F K L I +K Sbjct: 1327 --------FTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALH--INPAYIK 1376 Query: 378 QEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIH------ 431 I + Y + GK Q KA H+ + + ++ A E A C+ Sbjct: 1377 ARISFGYN--LQAQGKFQ-KAWNHFTIAIDTDPKNYL------AYEGRAVVCLQMGNNFA 1427 Query: 432 --QNVRVVESVSLL-------GLIHKLKGEVSDALLCYERALRL 466 Q++ +S G+IH+ G +A+ Y+ A+ L Sbjct: 1428 AMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471 Score = 29.6 bits (65), Expect = 6.2 Identities = 31/161 (19%), Positives = 64/161 (39%), Gaps = 22/161 (13%) Query: 208 RAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSV 267 +A+ +NP + R+ LQ +G+ + + A+ + ++ A + G+ Sbjct: 1366 KALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNN 1425 Query: 268 DKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAIC 327 A++ + A++ + T+ FL TN RG E + Q A+ Sbjct: 1426 FAAMQDINAAMKISTTAEFL------------------TN---RGVIHEFMGHK-QNAMK 1463 Query: 328 KFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLR 368 ++ I L + +AY + Y +A ++F K L+ Sbjct: 1464 DYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504 Score = 29.3 bits (64), Expect = 8.1 Identities = 34/144 (23%), Positives = 60/144 (41%), Gaps = 13/144 (9%) Query: 155 KNYERAKTCFEKALEGNPENPEFNTGYAITVYR-LDKFNTASGRNKAFSLHVLKRAVRLN 213 K YE + + + P F +YR L K +A ++ L+R + L Sbjct: 896 KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA--------MNDLQRVILLE 947 Query: 214 PD--DVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKAL 271 P + Y L QD+ EA + +++AY+ + A+ YR K + A+ Sbjct: 948 PLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK--AEIYRGKKDITLAI 1005 Query: 272 ELLKMALETTPTSAFLHHQMGLCY 295 A+++TPT A ++ + G Y Sbjct: 1006 LNYTQAIKSTPTDADIYFRRGEMY 1029 >gi|222418587 hypothetical protein LOC57495 [Homo sapiens] Length = 1742 Score = 33.1 bits (74), Expect = 0.56 Identities = 40/165 (24%), Positives = 72/165 (43%), Gaps = 29/165 (17%) Query: 234 AEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSV--DKALELLKMALETT-------PTS 284 AE EK +E I +F+ A K KG + +A L A+E T Sbjct: 194 AENEKTWQEISDEIKK---IFKAAVKLLHEKGKMKHSQAKRYLFSAIEDEFDFALGKQTP 250 Query: 285 AFLHHQMGLCYRAQMIQIK------------EATNWQPRG-QDRETVDRLVQLAICKFEK 331 AFL + +CY ++ I+ + T +PR +D E ++L++L +F Sbjct: 251 AFL--KKCVCYIRKIANIERFVKIPEMGKYMDITGTEPRIIRDPEAQEKLIKLRD-EFIP 307 Query: 332 TIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQL 376 TI+ + Y + ++G+ ++ E H+ +GL + +ED + Sbjct: 308 TIVASSNLRV-YTSVTHCDMKLGYSQEIENHYIEGLGKQFYEDMI 351 >gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] Length = 2481 Score = 32.3 bits (72), Expect = 0.96 Identities = 35/145 (24%), Positives = 62/145 (42%), Gaps = 19/145 (13%) Query: 328 KFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRF 387 K K + KR AY +L Y H+R+ +F K + + +L QE+ Sbjct: 382 KIAKDLGNKREEARAYSNLGSAY----HYRR---NFDKAMSYHNYVLELAQELMEKAIEM 434 Query: 388 QEHHGKSQDKAITHYLKGLK-IEKMSHSREKLLNALEKLAKRCIHQNVRVVESVSLLGLI 446 + + G + H + ++ +E+ E+ L E L R S LG+I Sbjct: 435 RAYAG------LGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRAS-----SNLGII 483 Query: 447 HKLKGEVSDALLCYERALRLAADLN 471 H++KG+ AL ++ L +A +L+ Sbjct: 484 HQMKGDYDTALKLHKTHLCIAQELS 508 Score = 31.6 bits (70), Expect = 1.6 Identities = 30/130 (23%), Positives = 52/130 (40%), Gaps = 19/130 (14%) Query: 342 AYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGK-SQDKAIT 400 AY ++ Y +G + +A ++ ++ L++ + + + H + + D+A+ Sbjct: 516 AYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQ 575 Query: 401 HYLKGLKIEKMSHSREKLLNALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCY 460 HY L I + + AL S LG H +GE A Y Sbjct: 576 HYQNHLNIARELRDIQSEARAL------------------SNLGNFHCSRGEYVQAAPYY 617 Query: 461 ERALRLAADL 470 E+ LRLA DL Sbjct: 618 EQYLRLAPDL 627 >gi|74271826 glutamine synthetase [Homo sapiens] Length = 373 Score = 32.3 bits (72), Expect = 0.96 Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 7/81 (8%) Query: 232 QEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQM 291 +E G KYIEEA+ +S + QY + Y KG +D A L ET+ + F Sbjct: 262 REENGLKYIEEAIEKLSKR---HQYHIRAYDPKGGLDNARRLTGFH-ETSNINDF---SA 314 Query: 292 GLCYRAQMIQIKEATNWQPRG 312 G+ R+ I+I + +G Sbjct: 315 GVANRSASIRIPRTVGQEKKG 335 >gi|74271837 glutamine synthetase [Homo sapiens] Length = 373 Score = 32.3 bits (72), Expect = 0.96 Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 7/81 (8%) Query: 232 QEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQM 291 +E G KYIEEA+ +S + QY + Y KG +D A L ET+ + F Sbjct: 262 REENGLKYIEEAIEKLSKR---HQYHIRAYDPKGGLDNARRLTGFH-ETSNINDF---SA 314 Query: 292 GLCYRAQMIQIKEATNWQPRG 312 G+ R+ I+I + +G Sbjct: 315 GVANRSASIRIPRTVGQEKKG 335 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.134 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,872,792 Number of Sequences: 37866 Number of extensions: 722772 Number of successful extensions: 2279 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 25 Number of HSP's successfully gapped in prelim test: 42 Number of HSP's that attempted gapping in prelim test: 2107 Number of HSP's gapped (non-prelim): 175 length of query: 474 length of database: 18,247,518 effective HSP length: 106 effective length of query: 368 effective length of database: 14,233,722 effective search space: 5238009696 effective search space used: 5238009696 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.