Guide to the Human Genome
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Search of human proteins with 58330892

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58330892 interferon-induced protein with tetratricopeptide
repeats 1-like [Homo sapiens]
         (474 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58330892 interferon-induced protein with tetratricopeptide re...   961   0.0  
gi|116534937 interferon-induced protein with tetratricopeptide r...   652   0.0  
gi|6912630 interferon-induced protein with tetratricopeptide rep...   520   e-147
gi|31542980 interferon-induced protein with tetratricopeptide re...   391   e-109
gi|72534658 interferon-induced protein with tetratricopeptide re...   391   e-109
gi|153082755 interferon-induced protein with tetratricopeptide r...   384   e-106
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       51   3e-06
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       51   3e-06
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ...    49   1e-05
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H...    42   0.001
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H...    42   0.001
gi|17149828 NMDA receptor regulated 1 [Homo sapiens]                   42   0.001
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ...    42   0.002
gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Ho...    40   0.005
gi|54607135 translocase of outer mitochondrial membrane 70 homol...    39   0.013
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    38   0.023
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 37   0.039
gi|83415184 transmembrane and tetratricopeptide repeat containin...    37   0.039
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]           35   0.11 
gi|118766328 transmembrane and tetratricopeptide repeat containi...    35   0.15 
gi|118766330 transmembrane and tetratricopeptide repeat containi...    35   0.15 
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-...    35   0.19 
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     34   0.25 
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    33   0.43 
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...    33   0.43 
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom...    33   0.43 
gi|222418587 hypothetical protein LOC57495 [Homo sapiens]              33   0.56 
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         32   0.96 
gi|74271826 glutamine synthetase [Homo sapiens]                        32   0.96 
gi|74271837 glutamine synthetase [Homo sapiens]                        32   0.96 

>gi|58330892 interferon-induced protein with tetratricopeptide
           repeats 1-like [Homo sapiens]
          Length = 474

 Score =  961 bits (2483), Expect = 0.0
 Identities = 474/474 (100%), Positives = 474/474 (100%)

Query: 1   MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60
           MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY
Sbjct: 1   MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60

Query: 61  VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120
           VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK
Sbjct: 61  VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120

Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180
           VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG
Sbjct: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180

Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240
           YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI
Sbjct: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240

Query: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300
           EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI
Sbjct: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300

Query: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360
           QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE
Sbjct: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360

Query: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420
           EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN
Sbjct: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420

Query: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF 474
           ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF
Sbjct: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAADLNPIF 474


>gi|116534937 interferon-induced protein with tetratricopeptide
           repeats 1 isoform 2 [Homo sapiens]
          Length = 478

 Score =  652 bits (1681), Expect = 0.0
 Identities = 319/469 (68%), Positives = 386/469 (82%)

Query: 1   MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60
           MS   D   ++DSL QLRCHFTW+L I+  E+PDLENR+ ++I+FLDTKY+VGIHNLLAY
Sbjct: 1   MSTNGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAY 60

Query: 61  VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120
           VKHLKGQNEEAL SLK+AE+L+Q+EH NQA++RSLVTWGNFAW+YYHMGRLAEAQTYLDK
Sbjct: 61  VKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEAQTYLDK 120

Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180
           VEN CKK +NP RYRMECPE+DCEEGWAL KCGGKNYERAK CFEK LE +PENPE + G
Sbjct: 121 VENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAG 180

Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240
           YAI+ YRLD F  A+  +K FSL  L++AVRLNPD+ YI+VLLALKLQDEGQEAEGEKYI
Sbjct: 181 YAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYI 240

Query: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300
           EEAL ++SSQ YVF+YAAKFYRRKGSVDKALELLK AL+ TPTS  LHHQ+GLCY+AQMI
Sbjct: 241 EEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMI 300

Query: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360
           QIKEAT  QPRGQ+RE +D++++ AI  FE  +  K TFE+A++DLA  Y E G+HRKAE
Sbjct: 301 QIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAE 360

Query: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420
           E+FQK L MK   ++  Q+IH+HYGRFQE   KS   AI HYLK +KIE+ S +R+K +N
Sbjct: 361 ENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSIN 420

Query: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAAD 469
           +L+KL  R + +    +ES+SLLG ++KL+G +++AL  YERALRLAAD
Sbjct: 421 SLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAAD 469


>gi|6912630 interferon-induced protein with tetratricopeptide
           repeats 5 [Homo sapiens]
          Length = 482

 Score =  520 bits (1339), Expect = e-147
 Identities = 258/453 (56%), Positives = 337/453 (74%), Gaps = 1/453 (0%)

Query: 14  LIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAYVKHLKGQNEEALV 73
           L++L CHFTW LL E  ++ ++E+ I ++++FL TK  + ++NLLAYVKHLKGQN++AL 
Sbjct: 13  LLELECHFTWNLLKEDIDLFEVEDTIGQQLEFLTTKSRLALYNLLAYVKHLKGQNKDALE 72

Query: 74  SLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDKVENTCKKFANPSR 133
            L++AE++IQ+EH+++ ++RSLVTWGN+AWVYYHM +L EAQ Y  K+ N CKK ++PS 
Sbjct: 73  CLEQAEEIIQQEHSDKEEVRSLVTWGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSN 132

Query: 134 YRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNT 193
           Y++ECPE DCE+GWAL K GGK Y++AK  FEKALE  P+NPEFN GYAITVYRLD  + 
Sbjct: 133 YKLECPETDCEKGWALLKFGGKYYQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDD-SD 191

Query: 194 ASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYV 253
             G  K+FSL  L++AV LNPD+ YI+V LALKLQD   EAEGEKYIEE L  ISSQ YV
Sbjct: 192 REGSVKSFSLGPLRKAVTLNPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYV 251

Query: 254 FQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQ 313
            +YAAKFYRRK S +KALELLK ALE TPTS+FLHHQMGLCYRAQMIQIK+AT+ +P+G+
Sbjct: 252 LRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGK 311

Query: 314 DRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFE 373
           D+  VD L+  AI  F+  +     F  AY DLA  YAE G +  AE+ F+K LR++   
Sbjct: 312 DKLKVDELISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENIT 371

Query: 374 DQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIHQN 433
           D  K +IHYHYGRFQE H KS++ AI HYL+ LK++  S  R KL +AL+KL+ + +  N
Sbjct: 372 DDHKHQIHYHYGRFQEFHRKSENTAIHHYLEALKVKDRSPLRTKLTSALKKLSTKRLCHN 431

Query: 434 VRVVESVSLLGLIHKLKGEVSDALLCYERALRL 466
              V+S+S LG ++KL+GE   A   YE+A ++
Sbjct: 432 ALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKI 464


>gi|31542980 interferon-induced protein with tetratricopeptide
           repeats 3 [Homo sapiens]
          Length = 490

 Score =  391 bits (1004), Expect = e-109
 Identities = 217/470 (46%), Positives = 301/470 (64%), Gaps = 23/470 (4%)

Query: 1   MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60
           MSE +   L E  L QL+CHFTW L  E     DLE+R+  +I+FL+T++   ++NLLAY
Sbjct: 1   MSEVTKNSL-EKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAY 59

Query: 61  VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120
           +KHL G NE AL  L++AE+LIQ+EHA+QA+IRSLVTWGN+AWVYYH+GRL++AQ Y+DK
Sbjct: 60  IKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDK 119

Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180
           V+ TCKKF+NP  Y +E  E+DCEEGW   KCG    ERAK CFEKALE  P NPEF++G
Sbjct: 120 VKQTCKKFSNP--YSIEYSELDCEEGWTQLKCG--RNERAKVCFEKALEEKPNNPEFSSG 175

Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240
            AI +Y LD     +   K FS  VLK+A+ L+PD+ Y++VLL LKLQ   +EAEGE+++
Sbjct: 176 LAIAMYHLD-----NHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFV 230

Query: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300
           EEAL     Q  V + AAKFYRRKG +DKA+EL +  LE+TP + +L+HQ+G CY+A++ 
Sbjct: 231 EEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVR 290

Query: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360
           Q++     +  G ++E ++ L Q A+    K +        AY DLAE            
Sbjct: 291 QMQNTGESEASG-NKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFL--------ET 341

Query: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420
           E +Q     ++  D  KQ+ H  Y   Q+++GKS+D A+ H L+GL I K S  +E++ +
Sbjct: 342 ECYQTPFNKEV-PDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKD 400

Query: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERAL-RLAAD 469
             + +++  + QN        L GLIHK  G++  A  CYE+ L RL  D
Sbjct: 401 QPQNVSENLLPQN--APNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRD 448


>gi|72534658 interferon-induced protein with tetratricopeptide
           repeats 3 [Homo sapiens]
          Length = 490

 Score =  391 bits (1004), Expect = e-109
 Identities = 217/470 (46%), Positives = 301/470 (64%), Gaps = 23/470 (4%)

Query: 1   MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60
           MSE +   L E  L QL+CHFTW L  E     DLE+R+  +I+FL+T++   ++NLLAY
Sbjct: 1   MSEVTKNSL-EKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAY 59

Query: 61  VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120
           +KHL G NE AL  L++AE+LIQ+EHA+QA+IRSLVTWGN+AWVYYH+GRL++AQ Y+DK
Sbjct: 60  IKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDK 119

Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180
           V+ TCKKF+NP  Y +E  E+DCEEGW   KCG    ERAK CFEKALE  P NPEF++G
Sbjct: 120 VKQTCKKFSNP--YSIEYSELDCEEGWTQLKCG--RNERAKVCFEKALEEKPNNPEFSSG 175

Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYI 240
            AI +Y LD     +   K FS  VLK+A+ L+PD+ Y++VLL LKLQ   +EAEGE+++
Sbjct: 176 LAIAMYHLD-----NHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFV 230

Query: 241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMI 300
           EEAL     Q  V + AAKFYRRKG +DKA+EL +  LE+TP + +L+HQ+G CY+A++ 
Sbjct: 231 EEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVR 290

Query: 301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360
           Q++     +  G ++E ++ L Q A+    K +        AY DLAE            
Sbjct: 291 QMQNTGESEASG-NKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFL--------ET 341

Query: 361 EHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLN 420
           E +Q     ++  D  KQ+ H  Y   Q+++GKS+D A+ H L+GL I K S  +E++ +
Sbjct: 342 ECYQTPFNKEV-PDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKD 400

Query: 421 ALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERAL-RLAAD 469
             + +++  + QN        L GLIHK  G++  A  CYE+ L RL  D
Sbjct: 401 QPQNVSENLLPQN--APNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRD 448


>gi|153082755 interferon-induced protein with tetratricopeptide
           repeats 2 [Homo sapiens]
          Length = 472

 Score =  384 bits (985), Expect = e-106
 Identities = 212/469 (45%), Positives = 297/469 (63%), Gaps = 17/469 (3%)

Query: 1   MSEESDGKLIEDSLIQLRCHFTWKLLIEAPEIPDLENRIWEEIQFLDTKYNVGIHNLLAY 60
           MSE +   L E SL QL+CHFTW L+     + D E++++   +F + ++   + NLLAY
Sbjct: 1   MSENNKNSL-ESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAY 59

Query: 61  VKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLAEAQTYLDK 120
           +KHLKGQNE AL  L+KAE+LIQ+EHA+QA+IRSLVTWGN+AWVYYHMGRL++ Q Y+DK
Sbjct: 60  LKHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDK 119

Query: 121 VENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEFNTG 180
           V++ C+KF++P  YR+E PE+DCEEGW   KCGG   ERAK CFEKALE  P+NPEF +G
Sbjct: 120 VKHVCEKFSSP--YRIESPELDCEEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSG 177

Query: 181 YAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKL---QDEG-QEAEG 236
            AI  YRLD +  +       ++  L++A+RLNPD+ Y++VLLALKL   ++EG +E EG
Sbjct: 178 LAIASYRLDNWPPSQN-----AIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEG 232

Query: 237 EKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYR 296
           EK +EEAL        V + AAKFYRRK   DKA+ELLK ALE  P +A+LH Q+G CYR
Sbjct: 233 EKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYR 292

Query: 297 AQMIQIKEATNWQPRGQ-DRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGH 355
           A++ Q+    N +  G   +  +  L+  A+   +K              LA  +A    
Sbjct: 293 AKVFQV---MNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQ 349

Query: 356 HRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSR 415
           +  AE +FQK    K      KQ +H  YG FQ +  K +DKAI H+++G+KI + S  +
Sbjct: 350 YEDAEYYFQKEF-SKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREK 408

Query: 416 EKLLNALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERAL 464
           EK+ + L+K+AK  + +N    E++ +L  + +L  ++  A    ER L
Sbjct: 409 EKMKDKLQKIAKMRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGL 457


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/401 (21%), Positives = 141/401 (35%), Gaps = 110/401 (27%)

Query: 111 LAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEG 170
           LA A      +E   + + +  +Y  +   V  + G  L   G    E AK C+ KA+E 
Sbjct: 119 LAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALG--RLEEAKACYLKAIET 176

Query: 171 NPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPD--DVYIRVLLALKLQ 228
            P        +A+    L     A G     ++H  ++AV L+P+  D YI         
Sbjct: 177 QPN-------FAVAWSNLGCVFNAQGEIW-LAIHHFEKAVTLDPNFLDAYIN-------- 220

Query: 229 DEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLH 288
                          L ++  +A +F  A   Y R             AL  +P  A +H
Sbjct: 221 ---------------LGNVLKEARIFDRAVAAYLR-------------ALSLSPNHAVVH 252

Query: 289 HQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAE 348
             +   Y  Q                      L+ LAI  + + I L+  F  AY +LA 
Sbjct: 253 GNLACVYYEQ---------------------GLIDLAIDTYRRAIELQPHFPDAYCNLAN 291

Query: 349 TYAEIGHHRKAEEHFQKGLRM-------------------------KIFEDQLK-----Q 378
              E G   +AE+ +   LR+                         +++   L+      
Sbjct: 292 ALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA 351

Query: 379 EIHYHYGRFQEHHGKSQDKAITHYLKGLKIE-KMSHSREKLLNALEKLA---------KR 428
             H +     +  GK Q+ A+ HY + ++I    + +   + N L+++           R
Sbjct: 352 AAHSNLASVLQQQGKLQE-ALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 410

Query: 429 CIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAAD 469
            I  N    ++ S L  IHK  G + +A+  Y  AL+L  D
Sbjct: 411 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/401 (21%), Positives = 141/401 (35%), Gaps = 110/401 (27%)

Query: 111 LAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEG 170
           LA A      +E   + + +  +Y  +   V  + G  L   G    E AK C+ KA+E 
Sbjct: 129 LAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALG--RLEEAKACYLKAIET 186

Query: 171 NPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPD--DVYIRVLLALKLQ 228
            P        +A+    L     A G     ++H  ++AV L+P+  D YI         
Sbjct: 187 QPN-------FAVAWSNLGCVFNAQGEIW-LAIHHFEKAVTLDPNFLDAYIN-------- 230

Query: 229 DEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLH 288
                          L ++  +A +F  A   Y R             AL  +P  A +H
Sbjct: 231 ---------------LGNVLKEARIFDRAVAAYLR-------------ALSLSPNHAVVH 262

Query: 289 HQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAE 348
             +   Y  Q                      L+ LAI  + + I L+  F  AY +LA 
Sbjct: 263 GNLACVYYEQ---------------------GLIDLAIDTYRRAIELQPHFPDAYCNLAN 301

Query: 349 TYAEIGHHRKAEEHFQKGLRM-------------------------KIFEDQLK-----Q 378
              E G   +AE+ +   LR+                         +++   L+      
Sbjct: 302 ALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA 361

Query: 379 EIHYHYGRFQEHHGKSQDKAITHYLKGLKIE-KMSHSREKLLNALEKLA---------KR 428
             H +     +  GK Q+ A+ HY + ++I    + +   + N L+++           R
Sbjct: 362 AAHSNLASVLQQQGKLQE-ALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTR 420

Query: 429 CIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAAD 469
            I  N    ++ S L  IHK  G + +A+  Y  AL+L  D
Sbjct: 421 AIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461


>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
           sapiens]
          Length = 860

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 67/276 (24%), Positives = 107/276 (38%), Gaps = 30/276 (10%)

Query: 119 DKVENTCKKFANPSRYRMECPEVDCEEGWALAKC--GGKNYERAKTCFEKALEGNPENPE 176
           +K+ +  K  A   R+          E  A+A    G   Y+ A   F   L+  P+   
Sbjct: 119 EKILSQAKSIAEQKRFPFATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVS 178

Query: 177 FNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEG 236
              G  I      K      +N   +L  L R + L PD   +    A  L   G+    
Sbjct: 179 AIYGRGIAY---GKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGR---- 231

Query: 237 EKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYR 296
              I EA+  ++ +A   Q +A+ YR +G++    E    A E    S  L+    +   
Sbjct: 232 ---INEAVNDLT-KAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIA-- 285

Query: 297 AQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH 356
                + +   +  RG        L++ AI  F++ +  K  F  AY  L + Y E+G+ 
Sbjct: 286 ----MLYKGLTFFHRG--------LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNF 333

Query: 357 RKAEEHFQKGLRMK---IFEDQLKQEIHYHYGRFQE 389
             A E FQK L +    +   QL+  + YH+G  QE
Sbjct: 334 EAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQE 369


>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
           sapiens]
          Length = 631

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 9/109 (8%)

Query: 102 AWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGK-----N 156
           AW    + R+ +    LDK ++T +  +  S    +   VD ++   L + G K      
Sbjct: 92  AWAKLDVDRILDE---LDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGK 148

Query: 157 YERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTA-SGRNKAFSLH 204
           Y+ A  C+ K ++ +P NP   T  A   +RL KF  A S  N A +L+
Sbjct: 149 YDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALN 197


>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
           sapiens]
          Length = 665

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 9/109 (8%)

Query: 102 AWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGK-----N 156
           AW    + R+ +    LDK ++T +  +  S    +   VD ++   L + G K      
Sbjct: 92  AWAKLDVDRILDE---LDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGK 148

Query: 157 YERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTA-SGRNKAFSLH 204
           Y+ A  C+ K ++ +P NP   T  A   +RL KF  A S  N A +L+
Sbjct: 149 YDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALN 197


>gi|17149828 NMDA receptor regulated 1 [Homo sapiens]
          Length = 866

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 29/91 (31%), Positives = 41/91 (45%), Gaps = 2/91 (2%)

Query: 252 YVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPR 311
           +V  Y A+ Y + G    ALE +  A+E+TPT   L       Y+     IKEA  W   
Sbjct: 375 WVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYK-HAGNIKEAARWMDE 433

Query: 312 GQDRETVDRLVQLAICKFE-KTIMLKRTFEM 341
            Q  +T DR +     K+  K  ++K   EM
Sbjct: 434 AQALDTADRFINSKCAKYMLKANLIKEAEEM 464



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 40/162 (24%), Positives = 66/162 (40%), Gaps = 18/162 (11%)

Query: 158 ERAKTCFEKALEGNPEN---PEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRL-N 213
           E+ K C +K L  N      P FNT    ++Y+ DK   A             ++ RL N
Sbjct: 304 EKFKECLDKFLRMNFSKGCPPVFNT--LRSLYK-DKEKVAIIEELVVGYETSLKSCRLFN 360

Query: 214 PDD----------VYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRR 263
           P+D          ++++  LA      GQ +   +YI  A+ S  +   +F   AK Y+ 
Sbjct: 361 PNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKH 420

Query: 264 KGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEA 305
            G++ +A   +  A        F++ +    Y  +   IKEA
Sbjct: 421 AGNIKEAARWMDEAQALDTADRFINSKCAK-YMLKANLIKEA 461


>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
           sapiens]
          Length = 807

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/153 (26%), Positives = 68/153 (44%), Gaps = 18/153 (11%)

Query: 240 IEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQM 299
           I EA+  ++ +A   Q +A+ YR +G++    E    A E    S  L+    +      
Sbjct: 179 INEAVNDLT-KAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIA----- 232

Query: 300 IQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKA 359
             + +   +  RG        L++ AI  F++ +  K  F  AY  L + Y E+G+   A
Sbjct: 233 -MLYKGLTFFHRG--------LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAA 283

Query: 360 EEHFQKGLRMK---IFEDQLKQEIHYHYGRFQE 389
            E FQK L +    +   QL+  + YH+G  QE
Sbjct: 284 TESFQKALLLNQNHVQTLQLRGMMLYHHGSLQE 316


>gi|33356128 NMDA receptor regulated 1-like protein isoform 1 [Homo
           sapiens]
          Length = 864

 Score = 40.0 bits (92), Expect = 0.005
 Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 2/91 (2%)

Query: 252 YVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPR 311
           +V  + A+ + + G    AL+ +  A+ +TPT   L +     Y+  +  +KEA  W   
Sbjct: 375 WVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYK-HIGNLKEAAKWMDE 433

Query: 312 GQDRETVDRLVQLAICKFE-KTIMLKRTFEM 341
            Q  +T DR +     K+  +  M+K   EM
Sbjct: 434 AQSLDTADRFINSKCAKYMLRANMIKEAEEM 464



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 17/58 (29%), Positives = 28/58 (48%), Gaps = 5/58 (8%)

Query: 353 IGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEK 410
           +G   +A E  +KGLR     + +K  + +H     +   K  D+AI  Y   LK++K
Sbjct: 59  LGKKEEAYEFVRKGLR-----NDVKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKLDK 111



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 21/89 (23%), Positives = 39/89 (43%), Gaps = 1/89 (1%)

Query: 217 VYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKM 276
           ++++  LA      GQ +    YI  A+ S  +   +F   AK Y+  G++ +A + +  
Sbjct: 374 LWVQYFLAQHFDKLGQYSLALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWMDE 433

Query: 277 ALETTPTSAFLHHQMGLCYRAQMIQIKEA 305
           A        F++ +    Y  +   IKEA
Sbjct: 434 AQSLDTADRFINSKCAK-YMLRANMIKEA 461


>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
           A [Homo sapiens]
          Length = 608

 Score = 38.5 bits (88), Expect = 0.013
 Identities = 41/195 (21%), Positives = 81/195 (41%), Gaps = 13/195 (6%)

Query: 104 VYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCG--GKNYERAK 161
           VY+H G+L   +  LD+VE     F    R R E      ++ +AL +    G N  + +
Sbjct: 403 VYHHRGQL---KILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQ 459

Query: 162 TCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDV--YI 219
              +   E   + P    GYA+    L         ++ +      + + L PD+   Y+
Sbjct: 460 AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYD-----KCIDLEPDNATTYV 514

Query: 220 RVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALE 279
              L L+LQ +     G + I +A+   +   + ++       ++G+++KA+++   A+ 
Sbjct: 515 HKGL-LQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAIN 573

Query: 280 TTPTSAFLHHQMGLC 294
              +   + H   LC
Sbjct: 574 LAKSEMEMAHLYSLC 588


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score = 37.7 bits (86), Expect = 0.023
 Identities = 40/175 (22%), Positives = 77/175 (44%), Gaps = 11/175 (6%)

Query: 298 QMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHR 357
           Q+  I EA   + RG D E +  L        E+   LK   E    +  E    + H  
Sbjct: 605 QLQAILEAER-RDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSE 663

Query: 358 KAEEHFQKGL--RMKIFEDQLKQEIHYHY---GRFQEHHGKSQD-KAITHYLKGLKIEKM 411
           K + + +  L  ++K  + +L+QE++ H     R  + H   ++ K++       K+++ 
Sbjct: 664 KEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEE 723

Query: 412 SHSREKLLNALEKLAKRCIHQNVRVVESVS----LLGLIHKLKGEVSDALLCYER 462
             +REK  N + ++ K+C   +V + +S      L G   +++ EV +  L  E+
Sbjct: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQ 778


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 37.0 bits (84), Expect = 0.039
 Identities = 67/255 (26%), Positives = 96/255 (37%), Gaps = 46/255 (18%)

Query: 146 GWALAKCGGKNYERAKTCFEKALEGNPENP-EFNTGYAITVYRLDKFNTASGRNKAFSLH 204
           G A      K+Y  A   ++KAL  NP  P E   G      +L+K   A     AFS  
Sbjct: 168 GKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKA---RLAFS-- 222

Query: 205 VLKRAVRLNPDDVYIRVLLALKLQDEGQEAE----GEKYIEEALTSISSQAYVFQYAAKF 260
              RA+ LN   V   V LA+ L+   +EA+    G + +  A T   S   V  + A  
Sbjct: 223 ---RALELNSKCVGALVGLAV-LELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANH 278

Query: 261 YRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDR 320
           +  K    K   L   A   T   A    Q   CY     Q+  + + Q      E  D+
Sbjct: 279 FFFKKDYSKVQHLALHAFHNTEVEAM---QAESCY-----QLARSFHVQ------EDYDQ 324

Query: 321 LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLR--------MKIF 372
             Q     ++ T     +F + +  L + Y   G    A + F+K L+        MKI 
Sbjct: 325 AFQY---YYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKIL 381

Query: 373 -------EDQLKQEI 380
                  EDQ K++I
Sbjct: 382 GSLYAASEDQEKRDI 396


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score = 37.0 bits (84), Expect = 0.039
 Identities = 69/335 (20%), Positives = 139/335 (41%), Gaps = 37/335 (11%)

Query: 160 AKTCFEKALEGNPENPE--FNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDV 217
           AK  +++AL+ +P++    FN G  +           S   K  ++ +LK +++  P+  
Sbjct: 425 AKMYYQRALQLHPQHNRALFNLGNLLK----------SQEKKEEAITLLKDSIKYGPEFA 474

Query: 218 YIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMA 277
                LA  L ++ +  E E+  +  + +    + +      F    G  +KA+   + A
Sbjct: 475 DAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQA 534

Query: 278 LETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPR----GQDRETVDRLVQL--------- 324
           ++ +P+       +G  YR+ + +   A  W  R        E +  L  L         
Sbjct: 535 IKLSPSHHVAMVNLGRLYRS-LGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEE 593

Query: 325 AICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHY 384
           A+  +++   L+ +     + LA+  A +G  ++AE+     +  +    +  + +   Y
Sbjct: 594 ALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIY 653

Query: 385 GRFQEHHGKSQ---DKAITHYLKGLKI------EKMSHSREK-LLNALEKLAKRCIHQNV 434
            + QE+H K+    DKA+    K  K+       K +  RE+ LL+   +  +  +  N 
Sbjct: 654 SK-QENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNP 712

Query: 435 RVVESVSLLGLIHKLKGEVSDALLCYERALRLAAD 469
              ++   +G I  +KG+   A   YERAL+L  D
Sbjct: 713 DQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPD 747


>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
          Length = 1564

 Score = 35.4 bits (80), Expect = 0.11
 Identities = 43/196 (21%), Positives = 82/196 (41%), Gaps = 31/196 (15%)

Query: 240 IEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQM 299
           ++E+    S   ++ +   K +R K +V    + LK+ ++    S    +Q  LC   + 
Sbjct: 299 LKESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALKI-VDNLGASGNSLYQRNLCLHLKA 357

Query: 300 IQIKEATNWQPRGQDRETVDRLVQ------LAICK---------FEKTIMLKRTFEMAYV 344
             + + +++    +   T+D++        L + K         F++   +      +Y 
Sbjct: 358 EALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYP 417

Query: 345 DLAETYA--EIGHHRK-----AEEHFQKGLRMKIFEDQLKQEIHYHYGR----FQEHHGK 393
           DLAE +A   + H  K     AE+ FQ+ L     +D    E HY  G       E   K
Sbjct: 418 DLAEVHALEALIHFTKKDYLQAEKCFQRALE----KDTEVAEYHYQLGLTYWFMGEETRK 473

Query: 394 SQDKAITHYLKGLKIE 409
            + KA+TH+LK  +++
Sbjct: 474 DKTKALTHFLKAARLD 489



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 23/75 (30%), Positives = 36/75 (48%)

Query: 221 VLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALET 280
           VL +L  +++G   E  K +E+ L+S    A V    A  +  K    +A +  + ALE 
Sbjct: 390 VLKSLAYRNKGSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEK 449

Query: 281 TPTSAFLHHQMGLCY 295
               A  H+Q+GL Y
Sbjct: 450 DTEVAEYHYQLGLTY 464



 Score = 30.4 bits (67), Expect = 3.7
 Identities = 18/55 (32%), Positives = 32/55 (58%), Gaps = 2/55 (3%)

Query: 155 KNYERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRA 209
           K+Y +A+ CF++ALE + E  E++    +T + + +  T   + KA + H LK A
Sbjct: 434 KDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGE-ETRKDKTKALT-HFLKAA 486


>gi|118766328 transmembrane and tetratricopeptide repeat containing
           4 isoform 2 [Homo sapiens]
          Length = 741

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 63/268 (23%), Positives = 106/268 (39%), Gaps = 30/268 (11%)

Query: 38  RIWEEIQFLDTKYNVGIHNLLAYVKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVT 97
           R + E   L+ KY   ++NL      LK +NE     L++AE+L+      Q D  +   
Sbjct: 503 RYYREAVRLNPKYVHAMNNL---GNILKERNE-----LQEAEELLSLAVQIQPDFAA--- 551

Query: 98  WGNFAWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNY 157
               AW+      L   Q  L + E   + +    ++R + P  DC             +
Sbjct: 552 ----AWM-----NLGIVQNSLKRFEAAEQSYRTAIKHRRKYP--DCYYNLGRLYADLNRH 600

Query: 158 ERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDV 217
             A   +  A    PE+   +  +   +  LD  NT    N A +  V + A+ L P+D 
Sbjct: 601 VDALNAWRNATVLKPEH---SLAWNNMIILLD--NTG---NLAQAEAVGREALELIPNDH 652

Query: 218 YIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMA 277
            +   LA  L    +  E E    +A+ +  + A      A  Y R G +D A +  +++
Sbjct: 653 SLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEIS 712

Query: 278 LETTPTSAFLHHQMGLCYRAQMIQIKEA 305
           L+  PT++      GL  R   +  K+A
Sbjct: 713 LQLDPTASGTKENYGLLRRKLELMQKKA 740


>gi|118766330 transmembrane and tetratricopeptide repeat containing
           4 isoform 1 [Homo sapiens]
          Length = 760

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 63/268 (23%), Positives = 106/268 (39%), Gaps = 30/268 (11%)

Query: 38  RIWEEIQFLDTKYNVGIHNLLAYVKHLKGQNEEALVSLKKAEDLIQKEHANQADIRSLVT 97
           R + E   L+ KY   ++NL      LK +NE     L++AE+L+      Q D  +   
Sbjct: 522 RYYREAVRLNPKYVHAMNNL---GNILKERNE-----LQEAEELLSLAVQIQPDFAA--- 570

Query: 98  WGNFAWVYYHMGRLAEAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNY 157
               AW+      L   Q  L + E   + +    ++R + P  DC             +
Sbjct: 571 ----AWM-----NLGIVQNSLKRFEAAEQSYRTAIKHRRKYP--DCYYNLGRLYADLNRH 619

Query: 158 ERAKTCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDV 217
             A   +  A    PE+   +  +   +  LD  NT    N A +  V + A+ L P+D 
Sbjct: 620 VDALNAWRNATVLKPEH---SLAWNNMIILLD--NTG---NLAQAEAVGREALELIPNDH 671

Query: 218 YIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMA 277
            +   LA  L    +  E E    +A+ +  + A      A  Y R G +D A +  +++
Sbjct: 672 SLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEIS 731

Query: 278 LETTPTSAFLHHQMGLCYRAQMIQIKEA 305
           L+  PT++      GL  R   +  K+A
Sbjct: 732 LQLDPTASGTKENYGLLRRKLELMQKKA 759


>gi|24308141 small glutamine-rich tetratricopeptide repeat
           (TPR)-containing, beta [Homo sapiens]
          Length = 304

 Score = 34.7 bits (78), Expect = 0.19
 Identities = 25/102 (24%), Positives = 47/102 (46%), Gaps = 8/102 (7%)

Query: 104 VYYHMGRLAEAQT--YLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAK 161
           VYY     A+++   Y D +++  K  A  S+Y      +       LA      +E A 
Sbjct: 120 VYYCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGRM------GLALTALNKFEEAV 173

Query: 162 TCFEKALEGNPENPEFNTGYAITVYRLDKFNTASGRNKAFSL 203
           T ++KAL+ +PEN  + +   I   +L + ++ +G   +F +
Sbjct: 174 TSYQKALDLDPENDSYKSNLKIAEQKLREVSSPTGTGLSFDM 215


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 34.3 bits (77), Expect = 0.25
 Identities = 27/100 (27%), Positives = 49/100 (49%), Gaps = 2/100 (2%)

Query: 196 GRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQ 255
           G++KA ++ V   A +LN  D  I   L +      Q  + +  +  AL +++     + 
Sbjct: 115 GKHKA-AIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNAL-NLNRHDLTYI 172

Query: 256 YAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCY 295
              K +  +G +DKA+E+ K A+E +P +  L   +GL Y
Sbjct: 173 MLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLY 212



 Score = 32.3 bits (72), Expect = 0.96
 Identities = 21/94 (22%), Positives = 40/94 (42%)

Query: 202 SLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFY 261
           ++ V K+AV  +P++  +   L L     G   +  +++  ALT   +       A    
Sbjct: 187 AIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMM 246

Query: 262 RRKGSVDKALELLKMALETTPTSAFLHHQMGLCY 295
           +  G  D AL   ++     P S  L + +G+C+
Sbjct: 247 QTHGDFDVALTKYRVVACAVPESPPLWNNIGMCF 280


>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 33.5 bits (75), Expect = 0.43
 Identities = 51/224 (22%), Positives = 85/224 (37%), Gaps = 50/224 (22%)

Query: 261  YRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDR 320
            Y   G    ALE  K A   + T+  L H   +C+  ++ + +EA N+            
Sbjct: 1280 YVELGQYGFALEDFKQAALISRTNGSLCHATAMCHH-RINEFEEAVNF------------ 1326

Query: 321  LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH---RKAEEHFQKGLRMKIFEDQLK 377
                    F   + +   F  AYV    +Y E GH    ++A++ F K L   I    +K
Sbjct: 1327 --------FTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALH--INPAYIK 1376

Query: 378  QEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIH------ 431
              I + Y    +  GK Q KA  H+   +  +  ++       A E  A  C+       
Sbjct: 1377 ARISFGYN--LQAQGKFQ-KAWNHFTIAIDTDPKNYL------AYEGRAVVCLQMGNNFA 1427

Query: 432  --QNVRVVESVSLL-------GLIHKLKGEVSDALLCYERALRL 466
              Q++     +S         G+IH+  G   +A+  Y+ A+ L
Sbjct: 1428 AMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 31/161 (19%), Positives = 64/161 (39%), Gaps = 22/161 (13%)

Query: 208  RAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSV 267
            +A+ +NP  +  R+     LQ +G+  +   +   A+ +       ++  A    + G+ 
Sbjct: 1366 KALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNN 1425

Query: 268  DKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAIC 327
              A++ +  A++ + T+ FL                  TN   RG   E +    Q A+ 
Sbjct: 1426 FAAMQDINAAMKISTTAEFL------------------TN---RGVIHEFMGHK-QNAMK 1463

Query: 328  KFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLR 368
             ++  I L   + +AY +    Y       +A ++F K L+
Sbjct: 1464 DYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 34/144 (23%), Positives = 60/144 (41%), Gaps = 13/144 (9%)

Query: 155  KNYERAKTCFEKALEGNPENPEFNTGYAITVYR-LDKFNTASGRNKAFSLHVLKRAVRLN 213
            K YE       + +    + P F       +YR L K  +A        ++ L+R + L 
Sbjct: 896  KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA--------MNDLQRVILLE 947

Query: 214  PD--DVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKAL 271
            P   + Y    L    QD+  EA  +          +++AY+ +  A+ YR K  +  A+
Sbjct: 948  PLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK--AEIYRGKKDITLAI 1005

Query: 272  ELLKMALETTPTSAFLHHQMGLCY 295
                 A+++TPT A ++ + G  Y
Sbjct: 1006 LNYTQAIKSTPTDADIYFRRGEMY 1029


>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 33.5 bits (75), Expect = 0.43
 Identities = 51/224 (22%), Positives = 85/224 (37%), Gaps = 50/224 (22%)

Query: 261  YRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDR 320
            Y   G    ALE  K A   + T+  L H   +C+  ++ + +EA N+            
Sbjct: 1280 YVELGQYGFALEDFKQAALISRTNGSLCHATAMCHH-RINEFEEAVNF------------ 1326

Query: 321  LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH---RKAEEHFQKGLRMKIFEDQLK 377
                    F   + +   F  AYV    +Y E GH    ++A++ F K L   I    +K
Sbjct: 1327 --------FTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALH--INPAYIK 1376

Query: 378  QEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIH------ 431
              I + Y    +  GK Q KA  H+   +  +  ++       A E  A  C+       
Sbjct: 1377 ARISFGYN--LQAQGKFQ-KAWNHFTIAIDTDPKNYL------AYEGRAVVCLQMGNNFA 1427

Query: 432  --QNVRVVESVSLL-------GLIHKLKGEVSDALLCYERALRL 466
              Q++     +S         G+IH+  G   +A+  Y+ A+ L
Sbjct: 1428 AMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 31/161 (19%), Positives = 64/161 (39%), Gaps = 22/161 (13%)

Query: 208  RAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSV 267
            +A+ +NP  +  R+     LQ +G+  +   +   A+ +       ++  A    + G+ 
Sbjct: 1366 KALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNN 1425

Query: 268  DKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAIC 327
              A++ +  A++ + T+ FL                  TN   RG   E +    Q A+ 
Sbjct: 1426 FAAMQDINAAMKISTTAEFL------------------TN---RGVIHEFMGHK-QNAMK 1463

Query: 328  KFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLR 368
             ++  I L   + +AY +    Y       +A ++F K L+
Sbjct: 1464 DYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 34/144 (23%), Positives = 60/144 (41%), Gaps = 13/144 (9%)

Query: 155  KNYERAKTCFEKALEGNPENPEFNTGYAITVYR-LDKFNTASGRNKAFSLHVLKRAVRLN 213
            K YE       + +    + P F       +YR L K  +A        ++ L+R + L 
Sbjct: 896  KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA--------MNDLQRVILLE 947

Query: 214  PD--DVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKAL 271
            P   + Y    L    QD+  EA  +          +++AY+ +  A+ YR K  +  A+
Sbjct: 948  PLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK--AEIYRGKKDITLAI 1005

Query: 272  ELLKMALETTPTSAFLHHQMGLCY 295
                 A+++TPT A ++ + G  Y
Sbjct: 1006 LNYTQAIKSTPTDADIYFRRGEMY 1029


>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
            sapiens]
          Length = 1614

 Score = 33.5 bits (75), Expect = 0.43
 Identities = 51/224 (22%), Positives = 85/224 (37%), Gaps = 50/224 (22%)

Query: 261  YRRKGSVDKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDR 320
            Y   G    ALE  K A   + T+  L H   +C+  ++ + +EA N+            
Sbjct: 1280 YVELGQYGFALEDFKQAALISRTNGSLCHATAMCHH-RINEFEEAVNF------------ 1326

Query: 321  LVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH---RKAEEHFQKGLRMKIFEDQLK 377
                    F   + +   F  AYV    +Y E GH    ++A++ F K L   I    +K
Sbjct: 1327 --------FTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALH--INPAYIK 1376

Query: 378  QEIHYHYGRFQEHHGKSQDKAITHYLKGLKIEKMSHSREKLLNALEKLAKRCIH------ 431
              I + Y    +  GK Q KA  H+   +  +  ++       A E  A  C+       
Sbjct: 1377 ARISFGYN--LQAQGKFQ-KAWNHFTIAIDTDPKNYL------AYEGRAVVCLQMGNNFA 1427

Query: 432  --QNVRVVESVSLL-------GLIHKLKGEVSDALLCYERALRL 466
              Q++     +S         G+IH+  G   +A+  Y+ A+ L
Sbjct: 1428 AMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 31/161 (19%), Positives = 64/161 (39%), Gaps = 22/161 (13%)

Query: 208  RAVRLNPDDVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSV 267
            +A+ +NP  +  R+     LQ +G+  +   +   A+ +       ++  A    + G+ 
Sbjct: 1366 KALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNN 1425

Query: 268  DKALELLKMALETTPTSAFLHHQMGLCYRAQMIQIKEATNWQPRGQDRETVDRLVQLAIC 327
              A++ +  A++ + T+ FL                  TN   RG   E +    Q A+ 
Sbjct: 1426 FAAMQDINAAMKISTTAEFL------------------TN---RGVIHEFMGHK-QNAMK 1463

Query: 328  KFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLR 368
             ++  I L   + +AY +    Y       +A ++F K L+
Sbjct: 1464 DYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 34/144 (23%), Positives = 60/144 (41%), Gaps = 13/144 (9%)

Query: 155  KNYERAKTCFEKALEGNPENPEFNTGYAITVYR-LDKFNTASGRNKAFSLHVLKRAVRLN 213
            K YE       + +    + P F       +YR L K  +A        ++ L+R + L 
Sbjct: 896  KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSA--------MNDLQRVILLE 947

Query: 214  PD--DVYIRVLLALKLQDEGQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKAL 271
            P   + Y    L    QD+  EA  +          +++AY+ +  A+ YR K  +  A+
Sbjct: 948  PLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK--AEIYRGKKDITLAI 1005

Query: 272  ELLKMALETTPTSAFLHHQMGLCY 295
                 A+++TPT A ++ + G  Y
Sbjct: 1006 LNYTQAIKSTPTDADIYFRRGEMY 1029


>gi|222418587 hypothetical protein LOC57495 [Homo sapiens]
          Length = 1742

 Score = 33.1 bits (74), Expect = 0.56
 Identities = 40/165 (24%), Positives = 72/165 (43%), Gaps = 29/165 (17%)

Query: 234 AEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSV--DKALELLKMALETT-------PTS 284
           AE EK  +E    I     +F+ A K    KG +   +A   L  A+E          T 
Sbjct: 194 AENEKTWQEISDEIKK---IFKAAVKLLHEKGKMKHSQAKRYLFSAIEDEFDFALGKQTP 250

Query: 285 AFLHHQMGLCYRAQMIQIK------------EATNWQPRG-QDRETVDRLVQLAICKFEK 331
           AFL  +  +CY  ++  I+            + T  +PR  +D E  ++L++L   +F  
Sbjct: 251 AFL--KKCVCYIRKIANIERFVKIPEMGKYMDITGTEPRIIRDPEAQEKLIKLRD-EFIP 307

Query: 332 TIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQL 376
           TI+      + Y  +     ++G+ ++ E H+ +GL  + +ED +
Sbjct: 308 TIVASSNLRV-YTSVTHCDMKLGYSQEIENHYIEGLGKQFYEDMI 351


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 32.3 bits (72), Expect = 0.96
 Identities = 35/145 (24%), Positives = 62/145 (42%), Gaps = 19/145 (13%)

Query: 328 KFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRF 387
           K  K +  KR    AY +L   Y    H+R+   +F K +    +  +L QE+       
Sbjct: 382 KIAKDLGNKREEARAYSNLGSAY----HYRR---NFDKAMSYHNYVLELAQELMEKAIEM 434

Query: 388 QEHHGKSQDKAITHYLKGLK-IEKMSHSREKLLNALEKLAKRCIHQNVRVVESVSLLGLI 446
           + + G      + H  + ++ +E+     E+ L   E L  R            S LG+I
Sbjct: 435 RAYAG------LGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRAS-----SNLGII 483

Query: 447 HKLKGEVSDALLCYERALRLAADLN 471
           H++KG+   AL  ++  L +A +L+
Sbjct: 484 HQMKGDYDTALKLHKTHLCIAQELS 508



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 30/130 (23%), Positives = 52/130 (40%), Gaps = 19/130 (14%)

Query: 342 AYVDLAETYAEIGHHRKAEEHFQKGLRMKIFEDQLKQEIHYHYGRFQEHHGK-SQDKAIT 400
           AY ++   Y  +G + +A ++ ++ L++ +  +    +   H      +    + D+A+ 
Sbjct: 516 AYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQ 575

Query: 401 HYLKGLKIEKMSHSREKLLNALEKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCY 460
           HY   L I +     +    AL                  S LG  H  +GE   A   Y
Sbjct: 576 HYQNHLNIARELRDIQSEARAL------------------SNLGNFHCSRGEYVQAAPYY 617

Query: 461 ERALRLAADL 470
           E+ LRLA DL
Sbjct: 618 EQYLRLAPDL 627


>gi|74271826 glutamine synthetase [Homo sapiens]
          Length = 373

 Score = 32.3 bits (72), Expect = 0.96
 Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 7/81 (8%)

Query: 232 QEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQM 291
           +E  G KYIEEA+  +S +    QY  + Y  KG +D A  L     ET+  + F     
Sbjct: 262 REENGLKYIEEAIEKLSKR---HQYHIRAYDPKGGLDNARRLTGFH-ETSNINDF---SA 314

Query: 292 GLCYRAQMIQIKEATNWQPRG 312
           G+  R+  I+I      + +G
Sbjct: 315 GVANRSASIRIPRTVGQEKKG 335


>gi|74271837 glutamine synthetase [Homo sapiens]
          Length = 373

 Score = 32.3 bits (72), Expect = 0.96
 Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 7/81 (8%)

Query: 232 QEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQM 291
           +E  G KYIEEA+  +S +    QY  + Y  KG +D A  L     ET+  + F     
Sbjct: 262 REENGLKYIEEAIEKLSKR---HQYHIRAYDPKGGLDNARRLTGFH-ETSNINDF---SA 314

Query: 292 GLCYRAQMIQIKEATNWQPRG 312
           G+  R+  I+I      + +G
Sbjct: 315 GVANRSASIRIPRTVGQEKKG 335


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,872,792
Number of Sequences: 37866
Number of extensions: 722772
Number of successful extensions: 2279
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 2107
Number of HSP's gapped (non-prelim): 175
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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