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Search of human proteins with 5729856
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5729856 GRB2-related adaptor protein [Homo sapiens]
(217 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 448 e-126
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 281 3e-76
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 209 1e-54
gi|193220941 hypothetical protein LOC400581 [Homo sapiens] 204 5e-53
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 164 5e-41
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 117 8e-27
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 104 7e-23
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 102 3e-22
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 102 3e-22
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 100 9e-22
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 100 9e-22
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 100 9e-22
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 100 9e-22
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 100 9e-22
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 100 9e-22
gi|4503787 fyn-related kinase [Homo sapiens] 99 4e-21
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 98 6e-21
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 96 2e-20
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 96 2e-20
gi|187475373 c-src tyrosine kinase [Homo sapiens] 94 9e-20
gi|4758078 c-src tyrosine kinase [Homo sapiens] 94 9e-20
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 94 1e-19
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 92 3e-19
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 92 3e-19
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 92 3e-19
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 91 8e-19
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 91 8e-19
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 91 1e-18
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 91 1e-18
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 91 1e-18
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 448 bits (1153), Expect = e-126
Identities = 217/217 (100%), Positives = 217/217 (100%)
Query: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
Sbjct: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
Query: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL
Sbjct: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
Query: 121 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR 180
WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR
Sbjct: 121 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR 180
Query: 181 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL 217
RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
Sbjct: 181 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL 217
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 281 bits (719), Expect = 3e-76
Identities = 129/216 (59%), Positives = 168/216 (77%), Gaps = 2/216 (0%)
Query: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
ME++A Y F+AT DEL+F +GD LK+LN E DQNWYKAEL G +GFIPKNYI +KPHPW
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60
Query: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
+ G+I R AEE+L K+ H GAFLIRESES+PG+FS+SV +G+ VQHFKVLR+ +GKYFL
Sbjct: 61 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL 120
Query: 121 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR 180
W KFNSLNELVD++R+T++++ +QIFLRD E + + P + QA FDF Q+ +L FR
Sbjct: 121 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP--TYVQALFDFDPQEDGELGFR 178
Query: 181 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVH 216
RGD I V++ DP+WW+G G+ G FPR+YV PV+
Sbjct: 179 RGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 214
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 209 bits (532), Expect = 1e-54
Identities = 103/216 (47%), Positives = 135/216 (62%), Gaps = 43/216 (19%)
Query: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
ME++A Y F+AT DEL+F +GD LK+LN E DQNWYKAEL G +GFIPKNYI +KPHP
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHP- 59
Query: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
+G+ VQHFKVLR+ +GKYFL
Sbjct: 60 ----------------------------------------FGNDVQHFKVLRDGAGKYFL 79
Query: 121 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFR 180
W KFNSLNELVD++R+T++++ +QIFLRD E + + P + QA FDF Q+ +L FR
Sbjct: 80 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQP--TYVQALFDFDPQEDGELGFR 137
Query: 181 RGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVH 216
RGD I V++ DP+WW+G G+ G FPR+YV PV+
Sbjct: 138 RGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 173
>gi|193220941 hypothetical protein LOC400581 [Homo sapiens]
Length = 118
Score = 204 bits (519), Expect = 5e-53
Identities = 100/100 (100%), Positives = 100/100 (100%)
Query: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW
Sbjct: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
Query: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVN 100
YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVN
Sbjct: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVN 100
Score = 38.5 bits (88), Expect = 0.004
Identities = 15/50 (30%), Positives = 30/50 (60%), Gaps = 1/50 (2%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLE-RPDPHWWRGRSCGRVGFFPRSYVQ 213
A + F A + +L+F +GD +++L D +W++ G GF P++Y++
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIR 54
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 164 bits (415), Expect = 5e-41
Identities = 79/150 (52%), Positives = 113/150 (75%), Gaps = 3/150 (2%)
Query: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
ME+VA + F A+ DEL+F+ GD LKIL+ +++ W+KAEL EG++PKN+I ++ W
Sbjct: 1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQEE--WFKAELGSQEGYVPKNFIDIQFPKW 58
Query: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
+ +SR AE +LM + +G F+IR S+SSPG+FS+SV + D VQHFKV+R+ G YFL
Sbjct: 59 FHEGLSRHQAENLLMGKE-VGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
Query: 121 WEEKFNSLNELVDFYRTTTIAKKRQIFLRD 150
W EKF SLN+LVD+YRT +I++++QIFLRD
Sbjct: 118 WTEKFPSLNKLVDYYRTNSISRQKQIFLRD 147
Score = 57.8 bits (138), Expect = 7e-09
Identities = 22/54 (40%), Positives = 36/54 (66%)
Query: 162 FAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPV 215
+A+A +DF A + +L F G+++EVL+ +P WW GR ++G FP +YV P+
Sbjct: 275 WARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPM 328
Score = 42.7 bits (99), Expect = 2e-04
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
ALY F+A E DEL F+ G+ +++L+ + +W+ L G P NY+
Sbjct: 278 ALYDFEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYV 325
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/50 (30%), Positives = 31/50 (62%), Gaps = 1/50 (2%)
Query: 163 AQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYV 212
A A+FDF+A +LSF GD++++L + W++ + G+ P++++
Sbjct: 3 AVAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGSQEGYVPKNFI 51
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 117 bits (293), Expect = 8e-27
Identities = 77/226 (34%), Positives = 117/226 (51%), Gaps = 33/226 (14%)
Query: 17 LAFNKGDTLKILNMEDDQNWYKAELRGVE--GFIPKNYIRVKP-----------HPWYSG 63
L N GD +++ E +QNW++ G+ P N RVKP H WY+G
Sbjct: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCN--RVKPYVHGPPQDLSVHLWYAG 674
Query: 64 RISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEE 123
+ R AE IL R+ G FL+R+ EF++S+ Y +V+H K++ A G Y + E+
Sbjct: 675 PMERAGAESILANRSD-GTFLVRQRVKDAAEFAISIKYNVEVKHIKIMT-AEGLYRITEK 732
Query: 124 K-FNSLNELVDFYRTTTI--------AKKRQIFLRDEEPLLKSPGA------CFAQAQFD 168
K F L ELV+FY+ ++ + F E+ + P A+A++D
Sbjct: 733 KAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYD 792
Query: 169 FSAQDPSQLSFRRGDIIEVLERPDPH-WWRGRSCGRVGFFPRSYVQ 213
F A+D S+LS + GDII++L + WWRG GRVG+FP +YV+
Sbjct: 793 FCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVE 838
Score = 48.1 bits (113), Expect = 6e-06
Identities = 20/49 (40%), Positives = 30/49 (61%)
Query: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
A Y F A + EL+ +GD +KILN + Q W++ E+ G G+ P NY+
Sbjct: 789 ARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 104 bits (259), Expect = 7e-23
Identities = 63/237 (26%), Positives = 117/237 (49%), Gaps = 41/237 (17%)
Query: 17 LAFNKGDTLKILNMEDDQNWYKAELRGVE--GFIPKNYIRVKP----------------- 57
L F GD L++L + + W++ L G+ P + ++ P
Sbjct: 599 LTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDY 658
Query: 58 --HPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREAS 115
+PW++G + RQ + +L K + G +LIRE + F++S+ + D+V+H KV+ + +
Sbjct: 659 TAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 717
Query: 116 GKYFLWEEKFNSLNELVDFYRTTTIA---KKRQIFLR--------------DEEPLLKSP 158
+ +KF+SL ELV++Y+ ++ K+ L+ P+
Sbjct: 718 WIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPR 777
Query: 159 GACFAQAQFDFSAQDPSQLSFRRGDIIEVLER--PDPHWWRGRSCGRVGFFPRSYVQ 213
A A+++F+A+D +LS R GD++ + R D WW+G + GR+G+FP +YV+
Sbjct: 778 VIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834
Score = 41.2 bits (95), Expect = 7e-04
Identities = 19/52 (36%), Positives = 31/52 (59%), Gaps = 1/52 (1%)
Query: 3 SVALYSFQATESDELAFNKGDTLKILN-MEDDQNWYKAELRGVEGFIPKNYI 53
+VA Y+F A + EL+ +GD ++I + + DQ W+K E G G+ P Y+
Sbjct: 782 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 102 bits (253), Expect = 3e-22
Identities = 54/139 (38%), Positives = 85/139 (61%), Gaps = 6/139 (4%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIR----VKPHP 59
VALY F A+ + L+ KG+ L++L + W +A+ + +G++P NYI ++ H
Sbjct: 67 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS 126
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK-Y 118
WY G +SR AE +L + G+FL+RESESSPG+ S+S+ Y +V H+++ + GK Y
Sbjct: 127 WYHGPVSRNAAEYLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 185
Query: 119 FLWEEKFNSLNELVDFYRT 137
E +FN+L ELV + T
Sbjct: 186 VSSESRFNTLAELVHHHST 204
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 102 bits (253), Expect = 3e-22
Identities = 54/139 (38%), Positives = 85/139 (61%), Gaps = 6/139 (4%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIR----VKPHP 59
VALY F A+ + L+ KG+ L++L + W +A+ + +G++P NYI ++ H
Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS 145
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK-Y 118
WY G +SR AE +L + G+FL+RESESSPG+ S+S+ Y +V H+++ + GK Y
Sbjct: 146 WYHGPVSRNAAEYLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 204
Query: 119 FLWEEKFNSLNELVDFYRT 137
E +FN+L ELV + T
Sbjct: 205 VSSESRFNTLAELVHHHST 223
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 100 bits (249), Expect = 9e-22
Identities = 53/139 (38%), Positives = 83/139 (59%), Gaps = 6/139 (4%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIR----VKPHP 59
VALY F A+ + L+ KG+ L++L + W + + +G++P NYI ++ H
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK-Y 118
WY G +SR AE +L + G+FL+RESESSPG+ S+S+ Y +V H+++ A GK Y
Sbjct: 158 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 216
Query: 119 FLWEEKFNSLNELVDFYRT 137
E +F++L ELV + T
Sbjct: 217 VTAESRFSTLAELVHHHST 235
Score = 30.0 bits (66), Expect = 1.6
Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLE-RPDPHWWRGRSCGRVGFFPRSYVQPVH 216
A +DF A + LS +G+ + VL + W RS G+ P +Y+ PV+
Sbjct: 99 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 151
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 100 bits (249), Expect = 9e-22
Identities = 53/139 (38%), Positives = 83/139 (59%), Gaps = 6/139 (4%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIR----VKPHP 59
VALY F A+ + L+ KG+ L++L + W + + +G++P NYI ++ H
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 172
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK-Y 118
WY G +SR AE +L + G+FL+RESESSPG+ S+S+ Y +V H+++ A GK Y
Sbjct: 173 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 231
Query: 119 FLWEEKFNSLNELVDFYRT 137
E +F++L ELV + T
Sbjct: 232 VTAESRFSTLAELVHHHST 250
Score = 30.0 bits (66), Expect = 1.6
Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLE-RPDPHWWRGRSCGRVGFFPRSYVQPVH 216
A +DF A + LS +G+ + VL + W RS G+ P +Y+ PV+
Sbjct: 114 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 166
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 100 bits (249), Expect = 9e-22
Identities = 53/139 (38%), Positives = 83/139 (59%), Gaps = 6/139 (4%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIR----VKPHP 59
VALY F A+ + L+ KG+ L++L + W + + +G++P NYI ++ H
Sbjct: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 151
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK-Y 118
WY G +SR AE +L + G+FL+RESESSPG+ S+S+ Y +V H+++ A GK Y
Sbjct: 152 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 210
Query: 119 FLWEEKFNSLNELVDFYRT 137
E +F++L ELV + T
Sbjct: 211 VTAESRFSTLAELVHHHST 229
Score = 30.0 bits (66), Expect = 1.6
Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLE-RPDPHWWRGRSCGRVGFFPRSYVQPVH 216
A +DF A + LS +G+ + VL + W RS G+ P +Y+ PV+
Sbjct: 93 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 145
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 100 bits (249), Expect = 9e-22
Identities = 53/139 (38%), Positives = 83/139 (59%), Gaps = 6/139 (4%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIR----VKPHP 59
VALY F A+ + L+ KG+ L++L + W + + +G++P NYI ++ H
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK-Y 118
WY G +SR AE +L + G+FL+RESESSPG+ S+S+ Y +V H+++ A GK Y
Sbjct: 158 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 216
Query: 119 FLWEEKFNSLNELVDFYRT 137
E +F++L ELV + T
Sbjct: 217 VTAESRFSTLAELVHHHST 235
Score = 30.0 bits (66), Expect = 1.6
Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLE-RPDPHWWRGRSCGRVGFFPRSYVQPVH 216
A +DF A + LS +G+ + VL + W RS G+ P +Y+ PV+
Sbjct: 99 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 151
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 100 bits (249), Expect = 9e-22
Identities = 53/139 (38%), Positives = 83/139 (59%), Gaps = 6/139 (4%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIR----VKPHP 59
VALY F A+ + L+ KG+ L++L + W + + +G++P NYI ++ H
Sbjct: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 136
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGK-Y 118
WY G +SR AE +L + G+FL+RESESSPG+ S+S+ Y +V H+++ A GK Y
Sbjct: 137 WYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 195
Query: 119 FLWEEKFNSLNELVDFYRT 137
E +F++L ELV + T
Sbjct: 196 VTAESRFSTLAELVHHHST 214
Score = 30.0 bits (66), Expect = 1.6
Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLE-RPDPHWWRGRSCGRVGFFPRSYVQPVH 216
A +DF A + LS +G+ + VL + W RS G+ P +Y+ PV+
Sbjct: 78 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVN 130
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 100 bits (249), Expect = 9e-22
Identities = 60/172 (34%), Positives = 91/172 (52%), Gaps = 33/172 (19%)
Query: 5 ALYSFQATESDELAFNKGDTLKILNM-EDDQNWYKA-ELRGVEGFIPKNYIRVKPH---- 58
ALY F ++ +EL F KGD + ++ E+D W+K ++ G+ G +PKNY+ V +
Sbjct: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLT 256
Query: 59 ------------------------PWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGE 94
PWY G+++R AE L +R H G FLIR+SESSP +
Sbjct: 257 SGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPND 316
Query: 95 FSVSVNYGDQVQHFKV-LREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQ 145
FSVS+ + +HFKV L+E Y + + KF+++ ELV+ Y+ I Q
Sbjct: 317 FSVSLKAQGKNKHFKVQLKET--VYCIGQRKFSTMEELVEHYKKAPIFTSEQ 366
Score = 56.6 bits (135), Expect = 2e-08
Identities = 57/250 (22%), Positives = 101/250 (40%), Gaps = 51/250 (20%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAE-LRGVEGFIPKNYIRVKPHPWYS 62
VA + + A + EL K + L +L +D ++W++ GF+P NY+ K
Sbjct: 8 VAKFDYVAQQEQELDIKKNERLWLL--DDSKSWWRVRNSMNKTGFVPSNYVERKN----- 60
Query: 63 GRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVS----VNYGDQVQHFKVLREASGKY 118
S + A + ++ LG ++ S P S + V+ G+++ + Y
Sbjct: 61 ---SARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNY 117
Query: 119 FLWEEKFNSL---------------------NELVDFYRTTTIAKKRQIFLRDEEPLLKS 157
E SL N V ++ + + ++ L D L
Sbjct: 118 MAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTEEGDSPLGDHVGSLSE 177
Query: 158 PGACFA------------QAQFDFSAQDPSQLSFRRGDIIEVLERP--DPHWWRGRSC-G 202
A QA + FS+ + +L+F +GD+++V+E+P DP WW+ R G
Sbjct: 178 KLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKING 237
Query: 203 RVGFFPRSYV 212
VG P++YV
Sbjct: 238 MVGLVPKNYV 247
Score = 35.0 bits (79), Expect = 0.049
Identities = 17/50 (34%), Positives = 29/50 (58%), Gaps = 2/50 (4%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR-SCGRVGFFPRSYVQ 213
A+FD+ AQ +L ++ + + +L+ WWR R S + GF P +YV+
Sbjct: 9 AKFDYVAQQEQELDIKKNERLWLLD-DSKSWWRVRNSMNKTGFVPSNYVE 57
Score = 33.1 bits (74), Expect = 0.19
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVK---P 57
M + +++ A DEL+ KG + ++ D W++ G G+ P NY+ + P
Sbjct: 109 MPAYVKFNYMAEREDELSLIKGTKVIVMEKCSD-GWWRGSYNGQVGWFPSNYVTEEGDSP 167
Query: 58 HPWYSGRISRQLA 70
+ G +S +LA
Sbjct: 168 LGDHVGSLSEKLA 180
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 98.6 bits (244), Expect = 4e-21
Identities = 68/201 (33%), Positives = 108/201 (53%), Gaps = 23/201 (11%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAEL--------RGVEGFIPKNYIR- 54
VAL+ +QA +++L+F GD L++L+ + W+ L + ++G+IP NY+
Sbjct: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
Query: 55 ---VKPHPWYSGRISRQLAE-EILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKV 110
++ PW+ G I R AE ++L N G+FLIRESES GEFS+SV G V+H+++
Sbjct: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRI 167
Query: 111 LREASGKYFLWEEK-FNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDF 169
R G +FL + F++LNE V Y T+ + ++ +P LK A FD
Sbjct: 168 KRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDG----LCVKLGKPCLKIQ----VPAPFDL 219
Query: 170 SAQDPSQLSFRRGDIIEVLER 190
S + Q R I++L+R
Sbjct: 220 SYKTVDQWEIDRNS-IQLLKR 239
Score = 39.7 bits (91), Expect = 0.002
Identities = 26/82 (31%), Positives = 39/82 (47%), Gaps = 19/82 (23%)
Query: 150 DEEPLLKSPGA-CFAQAQ---------FDFSAQDPSQLSFRRGDIIEVLERPDPHWW--- 196
D+ ++++PGA C Q+Q FD+ A+ LSFR GD ++VL+ WW
Sbjct: 24 DKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFAR 83
Query: 197 ------RGRSCGRVGFFPRSYV 212
G S G+ P +YV
Sbjct: 84 HLEKRRDGSSQQLQGYIPSNYV 105
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 97.8 bits (242), Expect = 6e-21
Identities = 65/266 (24%), Positives = 122/266 (45%), Gaps = 70/266 (26%)
Query: 17 LAFNKGDTLKILNMEDDQNWYKAELRGVE--GFIPKNYIRVKP----------------- 57
L F GD L++L + + W++ L G+ P + ++ P
Sbjct: 609 LTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDY 668
Query: 58 --HPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREAS 115
+PW++G + RQ + +L K + G +LIRE + F++S+ + D+V+H KV+ + +
Sbjct: 669 TAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 727
Query: 116 GKYFLWEEKFNSLNELVDFYRTTTIAKK-RQIFLRDEEPL-----------LKSPGAC-- 161
+ +KF+SL ELV++Y+ ++ + +Q+ + P +SP +C
Sbjct: 728 WIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCAS 787
Query: 162 --------------------------------FAQAQFDFSAQDPSQLSFRRGDIIEVLE 189
A A+++F+A+D +LS R GD++ +
Sbjct: 788 YNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYS 847
Query: 190 R--PDPHWWRGRSCGRVGFFPRSYVQ 213
R D WW+G + GR+G+FP +YV+
Sbjct: 848 RIGGDQGWWKGETNGRIGWFPSTYVE 873
Score = 41.2 bits (95), Expect = 7e-04
Identities = 19/52 (36%), Positives = 31/52 (59%), Gaps = 1/52 (1%)
Query: 3 SVALYSFQATESDELAFNKGDTLKILN-MEDDQNWYKAELRGVEGFIPKNYI 53
+VA Y+F A + EL+ +GD ++I + + DQ W+K E G G+ P Y+
Sbjct: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 96.3 bits (238), Expect = 2e-20
Identities = 64/233 (27%), Positives = 109/233 (46%), Gaps = 33/233 (14%)
Query: 13 ESDELAFNKGDTLKILNMEDDQNWYKAE--LRGVEGFIPKNYIRVKP----------HPW 60
E L GDT+++L + +++ G GF P + ++ P PW
Sbjct: 53 EGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPW 112
Query: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
Y+G + R AE L+ R + +L+R GE+++S+ Y ++ +H K+L +
Sbjct: 113 YAGAMERLQAETELINRVN-STYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 171
Query: 121 WEEKFNSLNELVDFYR-------TTTIAKKRQIFLRDEE------------PLLKSPGAC 161
KF SL ELV++Y+ T+ Q ++ E LL
Sbjct: 172 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLG 231
Query: 162 FAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPH-WWRGRSCGRVGFFPRSYVQ 213
A A++DF A+D +LS +GD++++ + + WWRG GRVG+FP +YV+
Sbjct: 232 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 284
Score = 40.0 bits (92), Expect = 0.002
Identities = 17/51 (33%), Positives = 27/51 (52%)
Query: 3 SVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
++A Y F A + EL+ KGD +KI W++ E+ G G+ P Y+
Sbjct: 233 AIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 283
Score = 33.1 bits (74), Expect = 0.19
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 12/88 (13%)
Query: 137 TTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQL------SFRRGDIIEVLER 190
T + +KR LR P PG Q ++S P L + GD +E+L +
Sbjct: 12 TLKLPEKRTNGLR-RTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL-K 69
Query: 191 PDPH--WWRGRSC--GRVGFFPRSYVQP 214
D H +W+GR+ G VGFFP V+P
Sbjct: 70 GDAHSLFWQGRNLASGEVGFFPSDAVKP 97
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 96.3 bits (238), Expect = 2e-20
Identities = 64/233 (27%), Positives = 109/233 (46%), Gaps = 33/233 (14%)
Query: 13 ESDELAFNKGDTLKILNMEDDQNWYKAE--LRGVEGFIPKNYIRVKP----------HPW 60
E L GDT+++L + +++ G GF P + ++ P PW
Sbjct: 613 EGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPW 672
Query: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
Y+G + R AE L+ R + +L+R GE+++S+ Y ++ +H K+L +
Sbjct: 673 YAGAMERLQAETELINRVN-STYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 731
Query: 121 WEEKFNSLNELVDFYR-------TTTIAKKRQIFLRDEE------------PLLKSPGAC 161
KF SL ELV++Y+ T+ Q ++ E LL
Sbjct: 732 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLG 791
Query: 162 FAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPH-WWRGRSCGRVGFFPRSYVQ 213
A A++DF A+D +LS +GD++++ + + WWRG GRVG+FP +YV+
Sbjct: 792 IAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 844
Score = 40.0 bits (92), Expect = 0.002
Identities = 17/51 (33%), Positives = 27/51 (52%)
Query: 3 SVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
++A Y F A + EL+ KGD +KI W++ E+ G G+ P Y+
Sbjct: 793 AIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYV 843
Score = 33.1 bits (74), Expect = 0.19
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 12/88 (13%)
Query: 137 TTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQL------SFRRGDIIEVLER 190
T + +KR LR P PG Q ++S P L + GD +E+L +
Sbjct: 572 TLKLPEKRTNGLR-RTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELL-K 629
Query: 191 PDPH--WWRGRSC--GRVGFFPRSYVQP 214
D H +W+GR+ G VGFFP V+P
Sbjct: 630 GDAHSLFWQGRNLASGEVGFFPSDAVKP 657
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 94.0 bits (232), Expect = 9e-20
Identities = 52/145 (35%), Positives = 83/145 (57%), Gaps = 12/145 (8%)
Query: 2 ESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELR-GVEGFIPKNYIRVKPH-- 58
E +A Y+F T +L F KGD L I+ + D NWYKA+ + G EG IP NY++ +
Sbjct: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72
Query: 59 --------PWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKV 110
PW+ G+I+R+ AE +L G FL+RES + PG++++ V+ +V+H+++
Sbjct: 73 AGTKLSLMPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCDGKVEHYRI 131
Query: 111 LREASGKYFLWEEKFNSLNELVDFY 135
+ AS E F +L +LV+ Y
Sbjct: 132 MYHASKLSIDEEVYFENLMQLVEHY 156
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 94.0 bits (232), Expect = 9e-20
Identities = 52/145 (35%), Positives = 83/145 (57%), Gaps = 12/145 (8%)
Query: 2 ESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELR-GVEGFIPKNYIRVKPH-- 58
E +A Y+F T +L F KGD L I+ + D NWYKA+ + G EG IP NY++ +
Sbjct: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72
Query: 59 --------PWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKV 110
PW+ G+I+R+ AE +L G FL+RES + PG++++ V+ +V+H+++
Sbjct: 73 AGTKLSLMPWFHGKITREQAERLLYPPE-TGLFLVRESTNYPGDYTLCVSCDGKVEHYRI 131
Query: 111 LREASGKYFLWEEKFNSLNELVDFY 135
+ AS E F +L +LV+ Y
Sbjct: 132 MYHASKLSIDEEVYFENLMQLVEHY 156
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 93.6 bits (231), Expect = 1e-19
Identities = 58/175 (33%), Positives = 97/175 (55%), Gaps = 13/175 (7%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAEL-RGVEGFIPKNYI----RVKPH 58
VALY ++A D+L+F+KG+ +ILN + W L G G+IP NY+ ++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 59 PWYSGRISRQLAE-EILMKRNHLGAFLIRESESSPGEFSVSVN-----YGDQVQHFKVLR 112
WY G++ R+ AE ++L N G FLIRESE++ G +S+S+ GD V+H+K+ +
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 113 EASGKYFL-WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQ 166
+G Y++ +F +L +LV Y T + + ++ +P SP + +AQ
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSGTWNGNTK-VAIKTLKPGTMSPESFLEEAQ 261
Score = 45.1 bits (105), Expect = 5e-05
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 2/59 (3%)
Query: 159 GACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRS--CGRVGFFPRSYVQPV 215
G A +D+ A+ LSF +G+ ++L + WW RS G G+ P +YV PV
Sbjct: 83 GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 92.0 bits (227), Expect = 3e-19
Identities = 55/144 (38%), Positives = 80/144 (55%), Gaps = 12/144 (8%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELR-GVEGFIPKNYIR----VKPH 58
+ALY ++A D+L F KG+ ILN + W L G G IP NY+ ++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 59 PWYSGRISRQLAE-EILMKRNHLGAFLIRESESSPGEFSVSV-----NYGDQVQHFKVLR 112
WY G+I R+ AE ++L N GAFLIRESE++ G +S+S+ GD V+H+K+ +
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 113 -EASGKYFLWEEKFNSLNELVDFY 135
+ G Y +FNS+ ELV Y
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHY 226
Score = 41.6 bits (96), Expect = 5e-04
Identities = 18/53 (33%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR--SCGRVGFFPRSYVQPV 215
A +D+ A+ L+F +G+ +L + WW R S G+ G P +YV PV
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 92.0 bits (227), Expect = 3e-19
Identities = 55/144 (38%), Positives = 80/144 (55%), Gaps = 12/144 (8%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELR-GVEGFIPKNYIR----VKPH 58
+ALY ++A D+L F KG+ ILN + W L G G IP NY+ ++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 59 PWYSGRISRQLAE-EILMKRNHLGAFLIRESESSPGEFSVSV-----NYGDQVQHFKVLR 112
WY G+I R+ AE ++L N GAFLIRESE++ G +S+S+ GD V+H+K+ +
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 113 -EASGKYFLWEEKFNSLNELVDFY 135
+ G Y +FNS+ ELV Y
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHY 226
Score = 41.6 bits (96), Expect = 5e-04
Identities = 18/53 (33%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR--SCGRVGFFPRSYVQPV 215
A +D+ A+ L+F +G+ +L + WW R S G+ G P +YV PV
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 92.0 bits (227), Expect = 3e-19
Identities = 55/144 (38%), Positives = 80/144 (55%), Gaps = 12/144 (8%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELR-GVEGFIPKNYIR----VKPH 58
+ALY ++A D+L F KG+ ILN + W L G G IP NY+ ++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 59 PWYSGRISRQLAE-EILMKRNHLGAFLIRESESSPGEFSVSV-----NYGDQVQHFKVLR 112
WY G+I R+ AE ++L N GAFLIRESE++ G +S+S+ GD V+H+K+ +
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 113 -EASGKYFLWEEKFNSLNELVDFY 135
+ G Y +FNS+ ELV Y
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHY 226
Score = 41.6 bits (96), Expect = 5e-04
Identities = 18/53 (33%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR--SCGRVGFFPRSYVQPV 215
A +D+ A+ L+F +G+ +L + WW R S G+ G P +YV PV
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 90.9 bits (224), Expect = 8e-19
Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 12/144 (8%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAEL-RGVEGFIPKNYI----RVKPH 58
VALY ++A D+L+F+KG+ +ILN + W L G G+IP NY+ ++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 59 PWYSGRISRQLAE-EILMKRNHLGAFLIRESESSPGEFSVSVN-----YGDQVQHFKVLR 112
WY G++ R+ AE ++L N G FLIRESE++ G +S+S+ GD V+H+K+ +
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 113 EASGKYFL-WEEKFNSLNELVDFY 135
+G Y++ +F +L +LV Y
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHY 231
Score = 45.1 bits (105), Expect = 5e-05
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 2/59 (3%)
Query: 159 GACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRS--CGRVGFFPRSYVQPV 215
G A +D+ A+ LSF +G+ ++L + WW RS G G+ P +YV PV
Sbjct: 83 GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 90.9 bits (224), Expect = 8e-19
Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 12/144 (8%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAEL-RGVEGFIPKNYI----RVKPH 58
VALY ++A D+L+F+KG+ +ILN + W L G G+IP NY+ ++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 59 PWYSGRISRQLAE-EILMKRNHLGAFLIRESESSPGEFSVSVN-----YGDQVQHFKVLR 112
WY G++ R+ AE ++L N G FLIRESE++ G +S+S+ GD V+H+K+ +
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 113 EASGKYFL-WEEKFNSLNELVDFY 135
+G Y++ +F +L +LV Y
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHY 231
Score = 45.1 bits (105), Expect = 5e-05
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 2/59 (3%)
Query: 159 GACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRS--CGRVGFFPRSYVQPV 215
G A +D+ A+ LSF +G+ ++L + WW RS G G+ P +YV PV
Sbjct: 83 GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 90.5 bits (223), Expect = 1e-18
Identities = 52/177 (29%), Positives = 92/177 (51%), Gaps = 24/177 (13%)
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLRE------ 113
WY GR+SRQ A +L + H G FL+R+S +SPG++ +SV+ +V H+ +
Sbjct: 13 WYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71
Query: 114 -----------ASGKYFLWEEKFNSLNELVDFYR-----TTTIAKKRQIFLRDEEPLLKS 157
+ + + +++F+SL L++FY+ TTT+ + + +L+
Sbjct: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQ 131
Query: 158 PGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR-SCGRVGFFPRSYVQ 213
A + +A FDF+ D L F++GDI+ + ++P+ WW S G+ G P YV+
Sbjct: 132 EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
Score = 40.8 bits (94), Expect = 9e-04
Identities = 17/49 (34%), Positives = 27/49 (55%)
Query: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
AL+ F + ++L F KGD L+I + ++Q W + G G IP Y+
Sbjct: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 90.5 bits (223), Expect = 1e-18
Identities = 52/177 (29%), Positives = 92/177 (51%), Gaps = 24/177 (13%)
Query: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLRE------ 113
WY GR+SRQ A +L + H G FL+R+S +SPG++ +SV+ +V H+ +
Sbjct: 13 WYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71
Query: 114 -----------ASGKYFLWEEKFNSLNELVDFYR-----TTTIAKKRQIFLRDEEPLLKS 157
+ + + +++F+SL L++FY+ TTT+ + + +L+
Sbjct: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQ 131
Query: 158 PGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR-SCGRVGFFPRSYVQ 213
A + +A FDF+ D L F++GDI+ + ++P+ WW S G+ G P YV+
Sbjct: 132 EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
Score = 40.8 bits (94), Expect = 9e-04
Identities = 17/49 (34%), Positives = 27/49 (55%)
Query: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
AL+ F + ++L F KGD L+I + ++Q W + G G IP Y+
Sbjct: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 90.5 bits (223), Expect = 1e-18
Identities = 56/163 (34%), Positives = 86/163 (52%), Gaps = 29/163 (17%)
Query: 6 LYSFQATESDELAFNKGDTLKILNM-EDDQNWYKAE-LRGVEGFIPKNYIRVKP-----H 58
LY F + +EL F KG+T++++ E+D W+K + RG G +PKNY+ V H
Sbjct: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALH 262
Query: 59 P---------------------WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSV 97
P WY G ++R AE L +R G FLIR+SESSP +FSV
Sbjct: 263 PAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSV 322
Query: 98 SVNYGDQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTI 140
S+ + +HFKV + Y + + +F++++ELV+ Y+ I
Sbjct: 323 SLKASGKNKHFKV-QLVDNVYCIGQRRFHTMDELVEHYKKAPI 364
Score = 52.8 bits (125), Expect = 2e-07
Identities = 55/251 (21%), Positives = 106/251 (42%), Gaps = 48/251 (19%)
Query: 4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAE-LRGVEGFIPKNYIRVKPHPWYS 62
+A + + A + EL K + L +L +D + W++ G++P NY+ K +
Sbjct: 8 IAKWDYTAQQDQELDIKKNERLWLL--DDSKTWWRVRNAANRTGYVPSNYVERK-NSLKK 64
Query: 63 GRISRQLAEEILM--KRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
G + + L + + + R A + S+ E+ + + D++ + A K+
Sbjct: 65 GSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNI--PAFVKFAY 122
Query: 121 WEEKFNSLNELVDFYRTTTIAK------------------KRQIFLRDEEPLLKSP---- 158
E+ + L+ LV R T + K + +E +SP
Sbjct: 123 VAEREDELS-LVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLS 181
Query: 159 ---GACFAQAQ-----------FDFSAQDPSQLSFRRGDIIEVLERP--DPHWWRGRSC- 201
GA + Q + FS+ +L+F +G+ +EV+E+P DP WW+ ++
Sbjct: 182 LRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNAR 241
Query: 202 GRVGFFPRSYV 212
G+VG P++YV
Sbjct: 242 GQVGLVPKNYV 252
Score = 33.1 bits (74), Expect = 0.19
Identities = 15/50 (30%), Positives = 30/50 (60%), Gaps = 2/50 (4%)
Query: 165 AQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCG-RVGFFPRSYVQ 213
A++D++AQ +L ++ + + +L+ WWR R+ R G+ P +YV+
Sbjct: 9 AKWDYTAQQDQELDIKKNERLWLLD-DSKTWWRVRNAANRTGYVPSNYVE 57
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,369,438
Number of Sequences: 37866
Number of extensions: 354177
Number of successful extensions: 1866
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 314
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 755
Number of HSP's gapped (non-prelim): 841
length of query: 217
length of database: 18,247,518
effective HSP length: 98
effective length of query: 119
effective length of database: 14,536,650
effective search space: 1729861350
effective search space used: 1729861350
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.