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Search of human proteins with 57165424
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57165424 cullin 4A isoform 1 [Homo sapiens]
(759 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57165424 cullin 4A isoform 1 [Homo sapiens] 1509 0.0
gi|11140811 cullin 4A isoform 2 [Homo sapiens] 1311 0.0
gi|121114302 cullin 4B isoform 2 [Homo sapiens] 1243 0.0
gi|121114298 cullin 4B isoform 1 [Homo sapiens] 1243 0.0
gi|4503165 cullin 3 [Homo sapiens] 500 e-141
gi|32307161 cullin 1 [Homo sapiens] 328 9e-90
gi|19482174 cullin 2 [Homo sapiens] 286 6e-77
gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1 ... 228 2e-59
gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens] 65 2e-10
gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo... 42 0.002
gi|169218008 PREDICTED: similar to anaphase-promoting complex su... 40 0.006
gi|50083279 centrosome protein 4 [Homo sapiens] 40 0.011
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 38 0.040
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 38 0.040
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 34 0.58
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 34 0.58
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 34 0.58
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 34 0.58
gi|4506751 restin isoform a [Homo sapiens] 32 1.7
gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens] 32 1.7
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 32 1.7
gi|239753136 PREDICTED: hypothetical protein [Homo sapiens] 32 2.2
gi|239747702 PREDICTED: hypothetical protein XP_002348252 [Homo ... 32 2.2
gi|239741569 PREDICTED: hypothetical protein XP_002342240 [Homo ... 32 2.2
gi|163659918 sacsin [Homo sapiens] 32 2.9
gi|4507531 toll-like receptor 3 [Homo sapiens] 31 3.7
gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo s... 31 3.7
gi|155969697 keratin 6C [Homo sapiens] 31 4.9
gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens] 31 4.9
gi|119703753 keratin 6B [Homo sapiens] 31 4.9
>gi|57165424 cullin 4A isoform 1 [Homo sapiens]
Length = 759
Score = 1509 bits (3908), Expect = 0.0
Identities = 759/759 (100%), Positives = 759/759 (100%)
Query: 1 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQ 60
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQ
Sbjct: 1 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQ 60
Query: 61 DTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILP 120
DTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILP
Sbjct: 61 DTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILP 120
Query: 121 FREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT 180
FREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT
Sbjct: 121 FREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT 180
Query: 181 HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETN 240
HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETN
Sbjct: 181 HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETN 240
Query: 241 CLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLT 300
CLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLT
Sbjct: 241 CLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLT 300
Query: 301 AILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD 360
AILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD
Sbjct: 301 AILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD 360
Query: 361 MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAG 420
MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAG
Sbjct: 361 MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAG 420
Query: 421 NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLK 480
NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLK
Sbjct: 421 NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLK 480
Query: 481 HECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPME 540
HECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPME
Sbjct: 481 HECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPME 540
Query: 541 VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLL 600
VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLL
Sbjct: 541 VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLL 600
Query: 601 MFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEF 660
MFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEF
Sbjct: 601 MFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEF 660
Query: 661 KHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY 720
KHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY
Sbjct: 661 KHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY 720
Query: 721 NQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
NQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
Sbjct: 721 NQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
>gi|11140811 cullin 4A isoform 2 [Homo sapiens]
Length = 659
Score = 1311 bits (3392), Expect = 0.0
Identities = 659/659 (100%), Positives = 659/659 (100%)
Query: 101 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY 160
MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY
Sbjct: 1 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY 60
Query: 161 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM 220
VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM
Sbjct: 61 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM 120
Query: 221 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH 280
LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
Sbjct: 121 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH 180
Query: 281 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW 340
STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW
Sbjct: 181 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW 240
Query: 341 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK 400
SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK
Sbjct: 241 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK 300
Query: 401 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 460
RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
Sbjct: 301 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 360
Query: 461 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP 520
LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP
Sbjct: 361 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP 420
Query: 521 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA 580
IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA
Sbjct: 421 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA 480
Query: 581 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI 640
EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI
Sbjct: 481 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI 540
Query: 641 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI 700
KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI
Sbjct: 541 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI 600
Query: 701 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
Sbjct: 601 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
>gi|121114302 cullin 4B isoform 2 [Homo sapiens]
Length = 895
Score = 1243 bits (3217), Expect = 0.0
Identities = 620/749 (82%), Positives = 683/749 (91%), Gaps = 5/749 (0%)
Query: 13 ALVGRTNGLTKPAALAA--APAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAV 70
A V NGL K + + A +KPG A KKLVIKNF+D+P+LP+NYT +TW+KL EAV
Sbjct: 150 ASVHHANGLAKSSTTVSSFANSKPGSA---KKLVIKNFKDKPKLPENYTDETWQKLKEAV 206
Query: 71 RAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVL 130
A+Q+STSI+YNLEELYQAVENLCS+K+S LYKQLRQ CEDH++AQI FREDSLDSVL
Sbjct: 207 EAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVL 266
Query: 131 FLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS 190
FLKKI+ CWQ+HCRQMIMIRSIFLFLDRTYVLQNS LPSIWDMGLELFR HIISD+ VQ+
Sbjct: 267 FLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQN 326
Query: 191 KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRL 250
KTIDGILLLIERER+GEA+DRSLLRSLL MLSDLQ+Y+DSFE +FLEETN LYAAEGQ+L
Sbjct: 327 KTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKL 386
Query: 251 MQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHL 310
MQEREVPEYL+HV+KRLEEE DR+ITYLD +TQK LIA VEKQLLGEHLTAILQKGL++L
Sbjct: 387 MQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNL 446
Query: 311 LDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKD 370
LDENR+ DL+ +YQLFSRVRGG Q LLQ W EYIK FG+ IVINPEKDK MVQ+LLDFKD
Sbjct: 447 LDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKD 506
Query: 371 KVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELE 430
KVDH+I++CF KNE+F+N MKE+FETFINKRPNKPAELIAK+VDSKLRAGNKEATDEELE
Sbjct: 507 KVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELE 566
Query: 431 RTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 490
+ LDKIMI+FRFI+GKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK
Sbjct: 567 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 626
Query: 491 LEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKL 550
LEGMFKDMELSKDIM+ FKQ+MQNQ+ G I+LTVNILTMGYWPTY PMEVHL PEM+KL
Sbjct: 627 LEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKL 686
Query: 551 QEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSF 610
QE+FK FYLGKHSGRKLQWQ+TLGH VLKAEFKEGKKE QVSLFQTLVLLMFNEG+ FS
Sbjct: 687 QEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSL 746
Query: 611 EEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKIN 670
EEIK ATGIED ELRRTLQSLACGKARVL K+PKGK++EDGDKFI N +FKHKLFRIKIN
Sbjct: 747 EEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKIN 806
Query: 671 QIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPG 730
QIQMKETVEEQ STTERVFQDRQYQIDAAIVRIMKMRKTL HNLLVSE+YNQLKFPVKP
Sbjct: 807 QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPA 866
Query: 731 DLKKRIESLIDRDYMERDKDNPNQYHYVA 759
DLKKRIESLIDRDYMERDK+NPNQY+Y+A
Sbjct: 867 DLKKRIESLIDRDYMERDKENPNQYNYIA 895
>gi|121114298 cullin 4B isoform 1 [Homo sapiens]
Length = 913
Score = 1243 bits (3217), Expect = 0.0
Identities = 620/749 (82%), Positives = 683/749 (91%), Gaps = 5/749 (0%)
Query: 13 ALVGRTNGLTKPAALAA--APAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAV 70
A V NGL K + + A +KPG A KKLVIKNF+D+P+LP+NYT +TW+KL EAV
Sbjct: 168 ASVHHANGLAKSSTTVSSFANSKPGSA---KKLVIKNFKDKPKLPENYTDETWQKLKEAV 224
Query: 71 RAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVL 130
A+Q+STSI+YNLEELYQAVENLCS+K+S LYKQLRQ CEDH++AQI FREDSLDSVL
Sbjct: 225 EAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVL 284
Query: 131 FLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS 190
FLKKI+ CWQ+HCRQMIMIRSIFLFLDRTYVLQNS LPSIWDMGLELFR HIISD+ VQ+
Sbjct: 285 FLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQN 344
Query: 191 KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRL 250
KTIDGILLLIERER+GEA+DRSLLRSLL MLSDLQ+Y+DSFE +FLEETN LYAAEGQ+L
Sbjct: 345 KTIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKL 404
Query: 251 MQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHL 310
MQEREVPEYL+HV+KRLEEE DR+ITYLD +TQK LIA VEKQLLGEHLTAILQKGL++L
Sbjct: 405 MQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNL 464
Query: 311 LDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKD 370
LDENR+ DL+ +YQLFSRVRGG Q LLQ W EYIK FG+ IVINPEKDK MVQ+LLDFKD
Sbjct: 465 LDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKD 524
Query: 371 KVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELE 430
KVDH+I++CF KNE+F+N MKE+FETFINKRPNKPAELIAK+VDSKLRAGNKEATDEELE
Sbjct: 525 KVDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELE 584
Query: 431 RTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 490
+ LDKIMI+FRFI+GKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK
Sbjct: 585 KMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 644
Query: 491 LEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKL 550
LEGMFKDMELSKDIM+ FKQ+MQNQ+ G I+LTVNILTMGYWPTY PMEVHL PEM+KL
Sbjct: 645 LEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKL 704
Query: 551 QEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSF 610
QE+FK FYLGKHSGRKLQWQ+TLGH VLKAEFKEGKKE QVSLFQTLVLLMFNEG+ FS
Sbjct: 705 QEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSL 764
Query: 611 EEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKIN 670
EEIK ATGIED ELRRTLQSLACGKARVL K+PKGK++EDGDKFI N +FKHKLFRIKIN
Sbjct: 765 EEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKIN 824
Query: 671 QIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPG 730
QIQMKETVEEQ STTERVFQDRQYQIDAAIVRIMKMRKTL HNLLVSE+YNQLKFPVKP
Sbjct: 825 QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPA 884
Query: 731 DLKKRIESLIDRDYMERDKDNPNQYHYVA 759
DLKKRIESLIDRDYMERDK+NPNQY+Y+A
Sbjct: 885 DLKKRIESLIDRDYMERDKENPNQYNYIA 913
>gi|4503165 cullin 3 [Homo sapiens]
Length = 768
Score = 500 bits (1288), Expect = e-141
Identities = 304/766 (39%), Positives = 437/766 (57%), Gaps = 51/766 (6%)
Query: 39 GSKKLVIKNFRDRPRLPDN-YTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHK 97
GS+K R P D Y W L A++ +Q + + EELY+ + HK
Sbjct: 9 GSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHK 68
Query: 98 VSPMLYKQLRQACEDHVQAQILPFREDSLDSVL--FLKKINTCWQDHCRQMIMIRSIFLF 155
LY LR+ +H+ ++ RED L+S+ FL+ +N W DH M+MIR I ++
Sbjct: 69 HGEKLYTGLREVVTEHLINKV---REDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 125
Query: 156 LDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLR 215
+DR YV QN+ + +++++GL +FR ++ ++ +L +I RER GE VDR +R
Sbjct: 126 MDRVYVQQNN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIR 184
Query: 216 SLLGMLSDL-----QVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE 270
+ ML L VY++ FE FLE + + E Q+ + E Y+ V R+ EE
Sbjct: 185 NACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEE 244
Query: 271 GDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDENRVPDLAQMYQLFS 327
+RV+ LD ST++P++ VE++L+ +H+ I++ GL H+L + DL MY+LFS
Sbjct: 245 IERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFS 304
Query: 328 RVRGGQQALLQHWSEYIKTFGTAIVINPEKDK---DMVQDLLDFKDKVDHVIEVCFQKNE 384
RV G + + + S Y++ G A+V + K D +Q LLD K + D + F +
Sbjct: 305 RVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDR 364
Query: 385 RFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIH 444
F + FE F+N P E ++ +D KL+ G K T++E+E LDK M+LFRF+
Sbjct: 365 LFKQTIAGDFEYFLNLNSRSP-EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQ 423
Query: 445 GKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDI 504
KDVFE +YK+ LA+RLL KS S D+EK+M+SKLK ECG FTSKLEGMF+DM +S
Sbjct: 424 EKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTT 483
Query: 505 MVHFKQHMQNQSDS-GPIDLTVNILTMGYWPTY--TPMEVHLTPEMIKLQEVFKAFYLGK 561
M F+QH+Q S G +DLTV +LT GYWPT TP + ++ P E+F+ FYL K
Sbjct: 484 MDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATP-KCNIPPAPRHAFEIFRRFYLAK 542
Query: 562 HSGRKLQWQTTLGHAVLKAEF-----KEGKKE-----------------FQVSLFQTLVL 599
HSGR+L Q +G A L A F KE E QVS FQ +L
Sbjct: 543 HSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTIL 602
Query: 600 LMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGK--ARVLIKSPKGKEVEDGDKFIFN 657
++FN + ++FEEI+ T I + EL R LQSLACGK RVL K PK KE+E+G F N
Sbjct: 603 MLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVN 662
Query: 658 GEFKHKLFRIKINQIQMK--ETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLL 715
+F KL R+KI + K E+ E+ T ++V DR+++I+AAIVRIMK RK + HN+L
Sbjct: 663 DQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVL 722
Query: 716 VSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
V+E+ QLK F P +KKRIE LI+R+Y+ R ++ Y YVA
Sbjct: 723 VAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
>gi|32307161 cullin 1 [Homo sapiens]
Length = 776
Score = 328 bits (842), Expect = 9e-90
Identities = 228/698 (32%), Positives = 366/698 (52%), Gaps = 49/698 (7%)
Query: 102 LYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV 161
LYK+L++ ++++ +L ED +D + LK W+D+ ++ I +L+R +V
Sbjct: 88 LYKRLKEFLKNYL-TNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKVLNGICAYLNRHWV 145
Query: 162 LQNST-----LPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRS 216
+ + I+ + L +R + + + + + +L LIE+ER+GE ++ L+
Sbjct: 146 RRECDEGRKGIYEIYSLALVTWRDCLF--RPLNKQVTNAVLKLIEKERNGETINTRLISG 203
Query: 217 L------LGMLSD--------LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNH 262
+ LG+ D L VYK+SFE +FL +T Y E +Q+ V EY+
Sbjct: 204 VVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKK 263
Query: 263 VSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQM 322
RL EE RV YL STQ L E+ L+ +HL I +LLD ++ DL +M
Sbjct: 264 AEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLE-IFHTEFQNLLDADKNEDLGRM 322
Query: 323 YQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEK-----DKDMVQDLLDFKDKVDHVIE 377
Y L SR++ G L + +I G A + + K VQ +LD K + ++
Sbjct: 323 YNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVM 382
Query: 378 VCFQKNERFVNLMKESFETFINKRP--------NKPAELIAKHVDSKLRAGNKEATDEEL 429
F + FV + ++ FIN +K EL+A++ DS L+ +K + EL
Sbjct: 383 SAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAEL 442
Query: 430 ERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTS 489
E TL+++M++F++I KDVF+ FY K LAKRL+ SAS DAE SM+SKLK CG +TS
Sbjct: 443 EDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTS 502
Query: 490 KLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIK 549
KL+ MF+D+ +SKD+ FK+H+ N S+ +D ++ +L+ G WP L E+ +
Sbjct: 503 KLQRMFQDIGVSKDLNEQFKKHLTN-SEPLDLDFSIQVLSSGSWPFQQSCTFALPSELER 561
Query: 550 LQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFS 609
+ F AFY +HSGRKL W L L + + Q S FQ +LL +N D ++
Sbjct: 562 SYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYT 621
Query: 610 FEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDK------FIFNGEFKHK 663
+++ +T I+ L + LQ L K+++L+ + V++ + ++ G +K+K
Sbjct: 622 VQQLTDSTQIKMDILAQVLQILL--KSKLLVLEDENANVDEVELKPDTLIKLYLG-YKNK 678
Query: 664 LFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQL 723
R+ IN E +EQ +T + + +DR+ I AAIVRIMKMRK L H L+ E+ QL
Sbjct: 679 KLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQL 738
Query: 724 KFPVKP--GDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
KP +KK I+ LI+++Y+ER + Y Y+A
Sbjct: 739 SSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
>gi|19482174 cullin 2 [Homo sapiens]
Length = 745
Score = 286 bits (731), Expect = 6e-77
Identities = 212/756 (28%), Positives = 370/756 (48%), Gaps = 61/756 (8%)
Query: 51 RPRLPDNYTQDTWRKLHEAVRAVQSSTSI-RYNLEELYQAVENLCSHKVSPM---LYKQL 106
+PR+ D +TW KL ++AV + R + + + LC P+ LY +
Sbjct: 4 KPRVVD--FDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTET 61
Query: 107 RQACEDHVQ---AQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ 163
+ E+HV+ ++L E L V++ + W+++ + + ++ +L+ ++ +
Sbjct: 62 KIFLENHVRHLHKRVLESEEQVL--VMY----HRYWEEYSKGADYMDCLYRYLNTQFIKK 115
Query: 164 NST-----------------LPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSG 206
N L I ++ L+++R ++ +Q+ I +L I+ +R G
Sbjct: 116 NKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEP--LQAILIRMLLREIKNDRGG 173
Query: 207 EAVDRSLLRSLLGMLSDLQVYKDSFELKF---------LEETNCLYAAEGQRLMQEREVP 257
E ++ ++ ++ ++ YK F LKF L ET Y E L+QE
Sbjct: 174 EDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCS 233
Query: 258 EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVP 317
+Y+ V RL++E R YL S+ +I +++++ +HL L +++ + +
Sbjct: 234 QYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQ-FLHAECHNIIRQEKKN 292
Query: 318 DLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD---MVQDLLDFKDKVDH 374
D+A MY L V G ++Q +I G N ++ V+ +L+ K
Sbjct: 293 DMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQ 352
Query: 375 VIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKLRAGNKEATDEELE 430
+I ++ F++ + ++ + +N R K EL+AK+ D+ L+ K T+ E+E
Sbjct: 353 LINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVE 412
Query: 431 RTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 490
L + +F++I KDVF+ FY + LAKRL+ G S S+D+E++M++KLK CG FTSK
Sbjct: 413 DRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSK 472
Query: 491 LEGMFKDMELSKDIMVHFKQHMQNQS---DSGPIDLTVNILTMGYWP-TYTPMEVHLTP- 545
L M+ DM +S D+ F ++NQ D G I + +L G WP T P P
Sbjct: 473 LHRMYTDMSVSADLNNKFNNFIKNQDTVIDLG-ISFQIYVLQAGAWPLTQAPSSTFAIPQ 531
Query: 546 EMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEG 605
E+ K ++F+ FY SGRKL W L +K + V+ +Q VLL FN
Sbjct: 532 ELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNS 591
Query: 606 DGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLF 665
+ S++E++ +T + + EL +T++SL +++ + ++++ F N F K
Sbjct: 592 ETVSYKELQDSTQMNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMNFSSKRT 649
Query: 666 RIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKF 725
+ KI K+T +E T V +DR+ + AAIVRIMK RK L HN L+ E+ +Q +
Sbjct: 650 KFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRA 709
Query: 726 PVKP--GDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
P +KK IE LID+ Y+ER + + ++Y YVA
Sbjct: 710 RFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 745
>gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1
[Homo sapiens]
Length = 780
Score = 228 bits (580), Expect = 2e-59
Identities = 203/773 (26%), Positives = 372/773 (48%), Gaps = 81/773 (10%)
Query: 60 QDTWRKLHEAVRAVQSSTSI-RYNLEELYQAVENLC--SHKVSPMLYKQLRQACEDHV-- 114
+D W + V + S+ + +L+ V +C K +++ L++ + +
Sbjct: 16 EDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQ 75
Query: 115 -QAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV-LQNSTLPS--- 169
QA++L ++D+ LK W+ Q ++ F L+ T + Q S S
Sbjct: 76 AQARVLSHQDDTA----LLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVE 131
Query: 170 ---IWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLL----RSLLGMLS 222
+ + L+ + I S+ ++++ D + L+ ER GEA D L+ S + + S
Sbjct: 132 DSIVRKLMLDTWNESIFSN--IKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCS 189
Query: 223 D----LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYL 278
+ LQ+Y+D+FE +L+ T Y + +Q+ V Y+ + +L+EE R + YL
Sbjct: 190 NPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYL 249
Query: 279 DHSTQ----KPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQ 334
+ + + L+ C L+ IL + ++ N L M+ L +V G +
Sbjct: 250 ETRRECNSVEALMECCVNALVTSFKETILAE-CQGMIKRNETEKLHLMFSLMDKVPNGIE 308
Query: 335 ALLQHWSEYIKTFGTAIVINPEK-----DKDMVQDLLDFKDKVDHVIEVCFQKNERFVNL 389
+L+ E+I + G A ++ + + V+ LL ++ +++ FQ + RF+
Sbjct: 309 PMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTA 368
Query: 390 MKESFETFIN--------------------KRPNKPAELIAKHVDSKLRAG--NKEATDE 427
++++ +N + +K EL+A + D LR +K+ T E
Sbjct: 369 RDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSE 428
Query: 428 ELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--A 485
E+E L +++++ +++ KDVF ++K L +RL++ SA + E++M+ L+ E G A
Sbjct: 429 EIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPA 487
Query: 486 AFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPID-LTVNILTMGYWP-TYTPMEVHL 543
+ +KL MF+D+++S+D+ FK+ +N + P D + + IL G W + + V L
Sbjct: 488 DYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSL 547
Query: 544 TPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFN 603
E+ L + FY HSGRKL W + + ++ + + G+ + +V+ FQ VL +N
Sbjct: 548 PTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWN 607
Query: 604 E--GDGFSFEEIKMATGIEDSELRRTLQSLACG---KARVLIKSPK---GKEVEDGDKFI 655
+ + SFE +K+AT + D+ELRRTL SL K +VL+ P+ K+ +G F
Sbjct: 608 QRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFS 667
Query: 656 FNGEFK-----HKLFRIKINQIQMKETVEEQV--STTERVFQDRQYQIDAAIVRIMKMRK 708
N EF R KIN I + E++ E + Q R + AI++IMKMRK
Sbjct: 668 VNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRK 727
Query: 709 TLGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
+ + L +EL LK F + +K++IE LI+ Y+ RD+ + N + Y+A
Sbjct: 728 KISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
>gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens]
Length = 822
Score = 65.5 bits (158), Expect = 2e-10
Identities = 52/200 (26%), Positives = 89/200 (44%), Gaps = 2/200 (1%)
Query: 431 RTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 490
R+ D I +L KD+F Y+ LA RLL S S + E + LK G A
Sbjct: 497 RSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHF 556
Query: 491 LEGMFKDMELSKDIMVHFKQHMQNQ--SDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMI 548
E M KDM S+ I + ++ + + + P + IL+ +WP + ++ + ++
Sbjct: 557 CEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIR 616
Query: 549 KLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGF 608
E + Y + R L W+ TLG + E + V+ Q ++LL F + +
Sbjct: 617 AALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASW 676
Query: 609 SFEEIKMATGIEDSELRRTL 628
+ EE+ A + + LRR +
Sbjct: 677 TLEELSKAVKMPVALLRRRM 696
>gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo
sapiens]
Length = 2517
Score = 42.0 bits (97), Expect = 0.002
Identities = 66/286 (23%), Positives = 121/286 (42%), Gaps = 70/286 (24%)
Query: 389 LMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDE-----ELERTLDKIMILFRFI 443
L+++SF T + +E A+++D +++ G +L+R L+ IM+L +
Sbjct: 1534 LLQQSFLTAAHM-----SEQFARYIDQQIQGGLIGGAPGVEMLGQLQRHLEPIMVLSG-L 1587
Query: 444 HGKDVFEAFYKKDLAKRLLVGKSASVDA--------------------EKSMLSKLKHEC 483
FE FY+ +A RLL S+ ++ S +L+ +
Sbjct: 1588 ELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQIGLCFPNRLPQLMLQSLSTSEELQRQF 1647
Query: 484 GAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS---------DSGPIDLTVNILTMGYWP 534
+L+ +F + E ++ + ++ + + D P +++ +L+ WP
Sbjct: 1648 HLFQLQRLDKLFLEQEDEEEKRLEEEEEEEEEEEAEKELFIEDPSPA-ISILVLSPRCWP 1706
Query: 535 T------YTPMEVHLTPEMIKLQEVFKAFY----------LGKHSGRKLQWQTTLGHAVL 578
Y P + L E + F +FY +G H R+LQW T LG
Sbjct: 1707 VSPLCYLYHPRKC-LPTEFCDALDRFSSFYSQSQNHPVLDMGPH--RRLQW-TWLG---- 1758
Query: 579 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSEL 624
+AE + GK+ VS Q +LL FN+ EE+ + T ++DS+L
Sbjct: 1759 RAELQFGKQILHVSTVQMWLLLKFNQ-----TEEVSVETLLKDSDL 1799
>gi|169218008 PREDICTED: similar to anaphase-promoting complex
subunit 2 [Homo sapiens]
Length = 430
Score = 40.4 bits (93), Expect = 0.006
Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 3/121 (2%)
Query: 431 RTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 490
R+ D I +L KD+F Y+ LA RLL S S + E + LK G A
Sbjct: 271 RSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHF 330
Query: 491 LEGMFKDMELSKDIMVHFKQHMQNQ--SDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMI 548
E M KDM S+ I + ++ + + + P + IL+ +WP + ++ + PE I
Sbjct: 331 CEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEV-PEDI 389
Query: 549 K 549
+
Sbjct: 390 R 390
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 39.7 bits (91), Expect = 0.011
Identities = 88/475 (18%), Positives = 184/475 (38%), Gaps = 103/475 (21%)
Query: 251 MQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHL 310
M E V +Y + R E E +R+ LD +++ + E L A L +D L
Sbjct: 222 MMESGVRDYSKQIELR-EREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFL 280
Query: 311 LDEN-----RVPDLAQ------------------MYQLFSRVRGGQQALLQHWSEYIKTF 347
N R+ +L + + Q + + Q L +H E ++T
Sbjct: 281 QQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETA 340
Query: 348 GTAIVINPEKDKDMVQDLLDFKD---KVDHVIEVCFQKNERFVN--LMKESFETFINKRP 402
+ ++ K + ++ D ++ K+ + +C ++ ER + L+K ET +++
Sbjct: 341 DKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLE 400
Query: 403 NKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMI-------------LFRFIHGKDVF 449
+ L +K V+S T+ +L ++++ + L F+ G +
Sbjct: 401 QEKQRL-SKKVESFA------VTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEE 453
Query: 450 EAFYKKDLAK--RLLVGKSASVD---AEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDI 504
+YKK+L + ++ +S S EKS + + + + S++ + ++ + + +
Sbjct: 454 RDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEK--GDYNSEIHQITRERDELQRM 511
Query: 505 MVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSG 564
+ F+++M+ D+ N+ LT E KL ++ +
Sbjct: 512 LERFEKYME--------DIQSNVKL-------------LTAERDKLSVLYNEAQEELSAL 550
Query: 565 RKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSEL 624
RK QTT H ++ +KE +++L ++ E E I+ + SEL
Sbjct: 551 RKESTQTTAPHNIVSLM----EKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSEL 606
Query: 625 RRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVE 679
+T++ L C N + + + + +K + MKET+E
Sbjct: 607 EKTIEHLTC----------------------VNHQLESEKYELKSKVLIMKETIE 639
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 37.7 bits (86), Expect = 0.040
Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 17/149 (11%)
Query: 303 LQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMV 362
LQK +D ++ E R +L ++ +ALL+ + K FG + N E +KD+
Sbjct: 1717 LQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLK---KVKKLFGESRGENEEMEKDLR 1773
Query: 363 QDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA--------ELIAKHVD 414
+ L D+K+KVD ++ + ++ ++E+ F + N A E + ++
Sbjct: 1774 EKLADYKNKVDDAWDLLREATDK----IREANRLFAVNQKNMTALEKKKEAVESGKRQIE 1829
Query: 415 SKLRAGNKEATDEELERTLDKIMILFRFI 443
+ L+ GN +E R D+I + ++
Sbjct: 1830 NTLKEGNDIL--DEANRLADEINSIIDYV 1856
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 37.7 bits (86), Expect = 0.040
Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 17/149 (11%)
Query: 303 LQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMV 362
LQK +D ++ E R +L ++ +ALL+ + K FG + N E +KD+
Sbjct: 1717 LQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLK---KVKKLFGESRGENEEMEKDLR 1773
Query: 363 QDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA--------ELIAKHVD 414
+ L D+K+KVD ++ + ++ ++E+ F + N A E + ++
Sbjct: 1774 EKLADYKNKVDDAWDLLREATDK----IREANRLFAVNQKNMTALEKKKEAVESGKRQIE 1829
Query: 415 SKLRAGNKEATDEELERTLDKIMILFRFI 443
+ L+ GN +E R D+I + ++
Sbjct: 1830 NTLKEGNDIL--DEANRLADEINSIIDYV 1856
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 33.9 bits (76), Expect = 0.58
Identities = 66/290 (22%), Positives = 116/290 (40%), Gaps = 43/290 (14%)
Query: 236 LEETNCLYAAEGQRLMQEREVP----EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVE 291
LEE + E + L Q+ E + L RL++E D ++ LD+ Q+ L++ +E
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLE 1447
Query: 292 KQLLGEHLTAILQKGLDHLLDE-----NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKT 346
K+ Q+ D LL E ++ D + +R + + L E
Sbjct: 1448 KK----------QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 347 FGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA 406
+ + K ++DL+ KD V + +K++R + E +T + + +
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELED--- 1553
Query: 407 ELIAKHVDSKLRAG-NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGK 465
EL A D+KLR N +A + ER L +D ++ L ++L +
Sbjct: 1554 ELQATE-DAKLRLEVNMQALKGQFERDLQ----------ARDEQNEEKRRQLQRQLHEYE 1602
Query: 466 SASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQ 515
+ D K + AA KLEG KD+EL D + ++ Q
Sbjct: 1603 TELEDERK------QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 33.9 bits (76), Expect = 0.58
Identities = 66/290 (22%), Positives = 116/290 (40%), Gaps = 43/290 (14%)
Query: 236 LEETNCLYAAEGQRLMQEREVP----EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVE 291
LEE + E + L Q+ E + L RL++E D ++ LD+ Q+ L++ +E
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLE 1454
Query: 292 KQLLGEHLTAILQKGLDHLLDE-----NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKT 346
K+ Q+ D LL E ++ D + +R + + L E
Sbjct: 1455 KK----------QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 347 FGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA 406
+ + K ++DL+ KD V + +K++R + E +T + + +
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELED--- 1560
Query: 407 ELIAKHVDSKLRAG-NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGK 465
EL A D+KLR N +A + ER L +D ++ L ++L +
Sbjct: 1561 ELQATE-DAKLRLEVNMQALKGQFERDLQ----------ARDEQNEEKRRQLQRQLHEYE 1609
Query: 466 SASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQ 515
+ D K + AA KLEG KD+EL D + ++ Q
Sbjct: 1610 TELEDERK------QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 33.9 bits (76), Expect = 0.58
Identities = 66/290 (22%), Positives = 116/290 (40%), Gaps = 43/290 (14%)
Query: 236 LEETNCLYAAEGQRLMQEREVP----EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVE 291
LEE + E + L Q+ E + L RL++E D ++ LD+ Q+ L++ +E
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLE 1454
Query: 292 KQLLGEHLTAILQKGLDHLLDE-----NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKT 346
K+ Q+ D LL E ++ D + +R + + L E
Sbjct: 1455 KK----------QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 347 FGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA 406
+ + K ++DL+ KD V + +K++R + E +T + + +
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELED--- 1560
Query: 407 ELIAKHVDSKLRAG-NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGK 465
EL A D+KLR N +A + ER L +D ++ L ++L +
Sbjct: 1561 ELQATE-DAKLRLEVNMQALKGQFERDLQ----------ARDEQNEEKRRQLQRQLHEYE 1609
Query: 466 SASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQ 515
+ D K + AA KLEG KD+EL D + ++ Q
Sbjct: 1610 TELEDERK------QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 33.9 bits (76), Expect = 0.58
Identities = 66/290 (22%), Positives = 116/290 (40%), Gaps = 43/290 (14%)
Query: 236 LEETNCLYAAEGQRLMQEREVP----EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVE 291
LEE + E + L Q+ E + L RL++E D ++ LD+ Q+ L++ +E
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLE 1447
Query: 292 KQLLGEHLTAILQKGLDHLLDE-----NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKT 346
K+ Q+ D LL E ++ D + +R + + L E
Sbjct: 1448 KK----------QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 347 FGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA 406
+ + K ++DL+ KD V + +K++R + E +T + + +
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELED--- 1553
Query: 407 ELIAKHVDSKLRAG-NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGK 465
EL A D+KLR N +A + ER L +D ++ L ++L +
Sbjct: 1554 ELQATE-DAKLRLEVNMQALKGQFERDLQ----------ARDEQNEEKRRQLQRQLHEYE 1602
Query: 466 SASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQ 515
+ D K + AA KLEG KD+EL D + ++ Q
Sbjct: 1603 TELEDERK------QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 32.3 bits (72), Expect = 1.7
Identities = 111/529 (20%), Positives = 202/529 (38%), Gaps = 78/529 (14%)
Query: 253 EREVPEYLNHVSK----------RLEEEGDRVITYLDHSTQKPL----IACVEKQLLGEH 298
+RE E LN + + R+EEE IT D TQ L I +E+ LL E
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEES---ITKGDLETQTKLEHARIKELEQSLLFEK 477
Query: 299 LTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKD 358
A L L++ RV +++ SR+ ++ L E + P D
Sbjct: 478 TKA---DKLQRELEDTRVATVSEK----SRIMELEKDLALRVQEVAELRRRLESNKPAGD 530
Query: 359 KDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLR 418
DM LL + +EV ++R + +KE F + E+ A + ++
Sbjct: 531 VDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA---REETHQKEIKALYTATEKL 587
Query: 419 AGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSK 478
+ E+ +LE + DV A +K L + + A + + S
Sbjct: 588 SKENESLKSKLEHANKE---------NSDVI-ALWKSKLETAIASHQQAMEELKVSFSKG 637
Query: 479 LKHECG--AAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTY 536
L E A +++E M D + H +++QNQ DS + +
Sbjct: 638 LGTETAEFAELKTQIEKMRLDYQ-------HEIENLQNQQDSERAAHAKEMEALRAKLMK 690
Query: 537 TPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLF-- 594
E + E I+ + L K + L + + +AE K KE +V
Sbjct: 691 VIKEKENSLEAIRSK-------LDKAEDQHLVEMEDTLNKLQEAEIKV--KELEVLQAKC 741
Query: 595 --QTLVL------LMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARV----LIKS 642
QT V+ L E + ++ A+ SE+++ Q L + ++ + K+
Sbjct: 742 NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 801
Query: 643 PKGKEVEDGDKFIFNGEFKHKLFRIKINQI-QMKETVEEQVSTTERVFQDRQYQIDAAIV 701
+ + + + E K + ++++ Q+KET+E+++ + F + + A+
Sbjct: 802 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS---EEAVS 858
Query: 702 RIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKD 750
M++T+ E +N L DL+K E+L D + R+KD
Sbjct: 859 VQRSMQETVNKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKD 902
>gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens]
Length = 4490
Score = 32.3 bits (72), Expect = 1.7
Identities = 39/155 (25%), Positives = 69/155 (44%), Gaps = 14/155 (9%)
Query: 330 RGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNL 389
R ++AL+ S ++ + IV + E + +V+ + F D V E FQ+ R ++
Sbjct: 2980 RWPREALIAVASYFLSDYN--IVCSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHV 3037
Query: 390 MKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVF 449
+S+ +FIN N AE K++ N++A E + LDK+M +
Sbjct: 3038 TPKSYLSFINGYKNIYAE--------KVKFINEQA--ERMNIGLDKLMEASESVAKLSQD 3087
Query: 450 EAFYKKDLAKRLLVGKS--ASVDAEKSMLSKLKHE 482
A +K+LA + A V +K+K+E
Sbjct: 3088 LAVKEKELAVASIKADEVLAEVTVSAQASAKIKNE 3122
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 32.3 bits (72), Expect = 1.7
Identities = 33/141 (23%), Positives = 62/141 (43%), Gaps = 24/141 (17%)
Query: 628 LQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLF-RIKINQIQMKETVEEQVSTTE 686
L+ + + L S G VE+ ++ I KH++F ++ Q + + + E++ T
Sbjct: 2026 LEEILAAQEVSLKTSALGSSVEEVEQLIR----KHEVFLKVLTAQDKKEAALRERLKTLR 2081
Query: 687 RV-FQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY------------------NQLKFPV 727
R +DR + +R+ ++ ++ GH L S L QLK PV
Sbjct: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141
Query: 728 KPGDLKKRIESLIDRDYMERD 748
PGDL+ +++ L+ E +
Sbjct: 2142 PPGDLRDKLKPLLKHQAFEAE 2162
>gi|239753136 PREDICTED: hypothetical protein [Homo sapiens]
Length = 136
Score = 32.0 bits (71), Expect = 2.2
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 7/55 (12%)
Query: 589 FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIED-------SELRRTLQSLACGKA 636
FQV + L+ + EG GF E I + TG ED + LQ ACG+A
Sbjct: 21 FQVCYRCDVPLIFYGEGTGFHHERINVLTGAEDQTEASSHTSTSLYLQPEACGRA 75
>gi|239747702 PREDICTED: hypothetical protein XP_002348252 [Homo
sapiens]
Length = 136
Score = 32.0 bits (71), Expect = 2.2
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 7/55 (12%)
Query: 589 FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIED-------SELRRTLQSLACGKA 636
FQV + L+ + EG GF E I + TG ED + LQ ACG+A
Sbjct: 21 FQVCYRCDVPLIFYGEGTGFHHERINVLTGAEDQTEASSHTSTSLYLQPEACGRA 75
>gi|239741569 PREDICTED: hypothetical protein XP_002342240 [Homo
sapiens]
Length = 136
Score = 32.0 bits (71), Expect = 2.2
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 7/55 (12%)
Query: 589 FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIED-------SELRRTLQSLACGKA 636
FQV + L+ + EG GF E I + TG ED + LQ ACG+A
Sbjct: 21 FQVCYRCDVPLIFYGEGTGFHHERINVLTGAEDQTEASSHTSTSLYLQPEACGRA 75
>gi|163659918 sacsin [Homo sapiens]
Length = 4579
Score = 31.6 bits (70), Expect = 2.9
Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 22/122 (18%)
Query: 253 EREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLD 312
E ++PE+L + ++L G V+ LD S Q PLI +K + +A+LQ
Sbjct: 833 EAQLPEFLADIVQKL---GGFVLKKLDASIQHPLI---KKYIHSPLPSAVLQ-------- 878
Query: 313 ENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKV 372
+ + + +L +++ +LL + ++ F ++ + EK+K ++Q+L FK ++
Sbjct: 879 ---IMEKMPLQKLCNQIT----SLLPTHKDALRKFLASLTDSSEKEKRIIQELAIFK-RI 930
Query: 373 DH 374
+H
Sbjct: 931 NH 932
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 31.2 bits (69), Expect = 3.7
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 350 AIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFIN--KRPNKPAE 407
A +I+ KDKD V + +K D ++ C ++ + + + E +N KR K
Sbjct: 758 AYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFE--LEAIVNSIKRSRKIIF 815
Query: 408 LIAKHVDSK---LRAGNKEATDEELERTLDKIMILF 440
+I H+ R A + +E+ LD I+++F
Sbjct: 816 VITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVF 851
>gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo
sapiens]
Length = 731
Score = 31.2 bits (69), Expect = 3.7
Identities = 55/258 (21%), Positives = 102/258 (39%), Gaps = 27/258 (10%)
Query: 176 ELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKF 235
E F T IIS + + + ++R+ + A D + M ++ K+ F LK
Sbjct: 198 EDFLTRIISQLQEAHEEKNELECALKRKIA--AYDEEIQHLYEEMEQQIKSEKEQFLLKD 255
Query: 236 LEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLL 295
E Q+L+ + + E L KRLE + T L H + + +L
Sbjct: 256 TERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQ----CTALHHDKHETKAENTKLKLT 311
Query: 296 GEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINP 355
+ L L++ L D + + Q Q+A H + ++ + +
Sbjct: 312 NQELARELERTSWELQDAQQQLESLQ-----------QEACKLHQEKEMEVYRVTESLQR 360
Query: 356 EKDKDMVQDLLDF-KDKVDHV---IEVCFQKNERFVNLMKESFETFINKRPNKPAELIAK 411
EK + Q LDF +++ H+ ++CFQKN+ K + + +I K
Sbjct: 361 EKAGLLKQ--LDFLRERNKHLRDERDICFQKNK----AAKANTAASRASWKKRSGSVIGK 414
Query: 412 HVDSKLRAGNKEATDEEL 429
+VDS+ ++ +EE+
Sbjct: 415 YVDSRGILRSQSEEEEEV 432
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 30.8 bits (68), Expect = 4.9
Identities = 36/189 (19%), Positives = 80/189 (42%), Gaps = 32/189 (16%)
Query: 453 YKKDLAKRL--LVGKSASVDAE----KSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMV 506
Y +L ++L +VG+ +D+E + ++ LK++ + + + L KD+
Sbjct: 217 YINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDA 276
Query: 507 HFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRK 566
+ ++ Q+ + + +N L Y + M+ H++ + L + R
Sbjct: 277 AYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSV---------VLSMDNNRN 327
Query: 567 LQWQTTLGHAVLKAEFKEGKKEFQV---SLFQTLVLLMFNEGDGFSFEEIKMATGIEDSE 623
L + + A +KA+++E + + S +QT +EE+++ G +
Sbjct: 328 LDLDSII--AEVKAQYEEIAQRSRAEAESWYQT------------KYEELQVTAGRHGDD 373
Query: 624 LRRTLQSLA 632
LR T Q +A
Sbjct: 374 LRNTKQEIA 382
>gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens]
Length = 4624
Score = 30.8 bits (68), Expect = 4.9
Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 5/136 (3%)
Query: 356 EKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDS 415
E K++VQ + F+D V FQ+ R ++ +S+ +FI E KHV+
Sbjct: 3140 EIKKEVVQCMGSFQDGVAEKCVDYFQRFRRSTHVTPKSYLSFIQGYKFIYGE---KHVEV 3196
Query: 416 KLRAGNKEATDEELERTLDKIMILFRFIHG--KDVFEAFYKKDLAKRLLVGKSASVDAEK 473
+ A E+L+ + + L + + K++ A K D+ + + K+ + + K
Sbjct: 3197 RTLANRMNTGLEKLKEASESVAALSKELEAKEKELQVANDKADMVLKEVTMKAQAAEKVK 3256
Query: 474 SMLSKLKHECGAAFTS 489
+ + K+K A S
Sbjct: 3257 AEVQKVKDRAQAIVDS 3272
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 30.8 bits (68), Expect = 4.9
Identities = 36/189 (19%), Positives = 80/189 (42%), Gaps = 32/189 (16%)
Query: 453 YKKDLAKRL--LVGKSASVDAE----KSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMV 506
Y +L ++L +VG+ +D+E + ++ LK++ + + + L KD+
Sbjct: 217 YINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDA 276
Query: 507 HFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRK 566
+ ++ Q+ + + +N L Y + M+ H++ + L + R
Sbjct: 277 AYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSV---------VLSMDNNRN 327
Query: 567 LQWQTTLGHAVLKAEFKEGKKEFQV---SLFQTLVLLMFNEGDGFSFEEIKMATGIEDSE 623
L + + A +KA+++E + + S +QT +EE+++ G +
Sbjct: 328 LDLDSII--AEVKAQYEEIAQRSRAEAESWYQT------------KYEELQITAGRHGDD 373
Query: 624 LRRTLQSLA 632
LR T Q +A
Sbjct: 374 LRNTKQEIA 382
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,642,370
Number of Sequences: 37866
Number of extensions: 1164116
Number of successful extensions: 3786
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 3723
Number of HSP's gapped (non-prelim): 68
length of query: 759
length of database: 18,247,518
effective HSP length: 110
effective length of query: 649
effective length of database: 14,082,258
effective search space: 9139385442
effective search space used: 9139385442
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.