Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 56847634
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56847634 hypothetical protein LOC441294 [Homo sapiens]
(777 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56847634 hypothetical protein LOC441294 [Homo sapiens] 1561 0.0
gi|146262005 CTAGE family, member 6 [Homo sapiens] 1555 0.0
gi|193290160 CTAGE family, member 4 [Homo sapiens] 1504 0.0
gi|224586773 hypothetical protein LOC643854 [Homo sapiens] 1493 0.0
gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens] 1300 0.0
gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens] 1261 0.0
gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens] 1248 0.0
gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens] 1215 0.0
gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isofo... 1144 0.0
gi|122891870 melanoma inhibitory activity family, member 3 [Homo... 242 8e-64
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 82 2e-15
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 80 7e-15
gi|55770834 centromere protein F [Homo sapiens] 80 9e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 79 1e-14
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 77 6e-14
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 77 8e-14
gi|118498356 kinectin 1 isoform a [Homo sapiens] 75 2e-13
gi|33620775 kinectin 1 isoform a [Homo sapiens] 75 2e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 75 3e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 75 3e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 75 3e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 75 3e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 74 4e-13
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 74 5e-13
gi|42794779 myosin 18A isoform b [Homo sapiens] 74 7e-13
gi|28416946 myosin 18A isoform a [Homo sapiens] 74 7e-13
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 73 9e-13
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 72 2e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 72 3e-12
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 72 3e-12
>gi|56847634 hypothetical protein LOC441294 [Homo sapiens]
Length = 777
Score = 1561 bits (4043), Expect = 0.0
Identities = 777/777 (100%), Positives = 777/777 (100%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW
Sbjct: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA
Sbjct: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE
Sbjct: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE
Sbjct: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ
Sbjct: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ
Sbjct: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE
Sbjct: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
Query: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR
Sbjct: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ
Sbjct: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
Query: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP
Sbjct: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
Query: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE
Sbjct: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP
Sbjct: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF 777
FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF
Sbjct: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF 777
>gi|146262005 CTAGE family, member 6 [Homo sapiens]
Length = 777
Score = 1555 bits (4027), Expect = 0.0
Identities = 773/777 (99%), Positives = 776/777 (99%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW
Sbjct: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA
Sbjct: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE
Sbjct: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG+VSE
Sbjct: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ
Sbjct: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ
Sbjct: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
TQQ SLQSENIYFESENQKLQQKLKIMTEFYQE+EMKLYRKLTVEENYRIEEEEKLS+VE
Sbjct: 361 TQQESLQSENIYFESENQKLQQKLKIMTEFYQEDEMKLYRKLTVEENYRIEEEEKLSKVE 420
Query: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR
Sbjct: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ
Sbjct: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
Query: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP
Sbjct: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
Query: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE
Sbjct: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP
Sbjct: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF 777
FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF
Sbjct: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF 777
>gi|193290160 CTAGE family, member 4 [Homo sapiens]
Length = 777
Score = 1504 bits (3893), Expect = 0.0
Identities = 751/777 (96%), Positives = 758/777 (97%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW
Sbjct: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA
Sbjct: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE
Sbjct: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG+VSE
Sbjct: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ
Sbjct: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ
Sbjct: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE
Sbjct: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
Query: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EK+SRATE LETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR
Sbjct: 421 EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREH+P P+PLG+ SSETRAF SPQ
Sbjct: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
Query: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
TLLEDPL LSPVLP GGGRGP PGNPLDHQITNERGEPS DRL DPHRAPSDTGSLSSP
Sbjct: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
Query: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
VEQD +MMFPPPGQSYPDS LPPQREDRFYSNSERLSG AEPRSFKMTSLDKMD SMPSE
Sbjct: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
MESSRNDAKDDLGNLNVPDSSLPAENEATGPG IPPPLAP+ GPLFPVDTRGPFMRRGPP
Sbjct: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF 777
FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPY HPRPGFYPNP F
Sbjct: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF 777
>gi|224586773 hypothetical protein LOC643854 [Homo sapiens]
Length = 777
Score = 1493 bits (3866), Expect = 0.0
Identities = 746/777 (96%), Positives = 755/777 (97%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPGATPQPYLGLVLEEL RVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW
Sbjct: 1 MEEPGATPQPYLGLVLEELGRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA
Sbjct: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
AAEEARSLEATCEKL+RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE
Sbjct: 121 AAEEARSLEATCEKLSRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE
Sbjct: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLEL+VNSQ
Sbjct: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELKVNSQ 300
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
WENGANLDDP KGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ
Sbjct: 301 WENGANLDDPPKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE
Sbjct: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
Query: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EK+S ATE+LETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR
Sbjct: 421 EKISHATEELETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
KENAHNKQKLTE ELKFELLEKDPNALDVSNTAFGREH+P P+PLG+ SSETRAF SPQ
Sbjct: 481 KENAHNKQKLTERELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
Query: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
TLLEDPL LSPVLP GGGRGP PGNPLDHQITNERGEPS DRL DPHRAPSDTGSLSSP
Sbjct: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
Query: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
VEQD +MMFPPPGQSYPDS LPPQREDRFYSNSERLSG AEPRSFKMTSLDKMD SMPSE
Sbjct: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
MESSRNDAKDDLGNLNVPDSSLPAENEATGPG IPPPLAP+ GPLFPVDTRGPFMRRGPP
Sbjct: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF 777
FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPY HPRPGFYPNP F
Sbjct: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF 777
>gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]
Length = 804
Score = 1300 bits (3364), Expect = 0.0
Identities = 651/775 (84%), Positives = 699/775 (90%), Gaps = 2/775 (0%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPG TPQPYLGL+LEELRRVVAALPE MRPD N YGFP ELV+CAAV+GFF VL FLW
Sbjct: 1 MEEPGVTPQPYLGLLLEELRRVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGRE+KL LSGLIEEK KLLEKFSL+QKEYEGYEVESSL+DASFEK
Sbjct: 61 RSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKE 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
A E A+SLEATCEKLNRSNSELEDEILCLEK+LKEEKSKHS+QDELMADISK IQSLEDE
Sbjct: 121 ATE-AQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDE 179
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
SKSLKSQ+AEAK+ K F+M+EER IAIKDALNENSQLQ S KQL Q EAEVWK QVSE
Sbjct: 180 SKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQ-EAEVWKEQVSE 238
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQK+TFEDSKVHAEQVLNDKE+HIKTLT L MKD AA+L ED TDDDNLELE+NS+
Sbjct: 239 LNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSE 298
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
ENGA LD+P KGALKKLIHAAKLN SLK+LEGERN I IQLSEVDKTKEELTEHIKNLQ
Sbjct: 299 SENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQ 358
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
T+QASLQSEN +FE+ENQKLQQKLK+MTE YQENEMKL+RKLTVEENYR+E+EEKLS+V+
Sbjct: 359 TEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVD 418
Query: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EK+S ATE+LETYRK AKDLEEELERT+H YQ Q+IS+EK+ HDNWLAAR AERNL+DLR
Sbjct: 419 EKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLR 478
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
KENAHN+QKLTETELKFELLEKDP ALDV NTAFGREH+P GP+PLG SSETRAFLSP
Sbjct: 479 KENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPP 538
Query: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
TLLE PL LSP+LP GGGRG RGPGNPLDHQITNERGE SCDRLTDPHRAPSDTGSLS P
Sbjct: 539 TLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPP 598
Query: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
+QD +MMFPPPGQSYPDSALPPQR+DRF SNS RLSG AE RSF M SLDKMDGSMPSE
Sbjct: 599 WDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSE 658
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
MESSRND KDDLGNLNVPDSSLPAENEATGPGF+PPPLAP+RGPLFPVD RGPF+RRGPP
Sbjct: 659 MESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPP 718
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNP 775
FPPPPPG MFGASR YFPP DFPGPP APFAMRN+YPPRG PPY PRPGF+P P
Sbjct: 719 FPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPP 773
>gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens]
Length = 792
Score = 1261 bits (3262), Expect = 0.0
Identities = 632/754 (83%), Positives = 679/754 (90%), Gaps = 2/754 (0%)
Query: 22 VVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGAT 81
VVAALPE MRPD N YGFP ELV+CAAV+GFF VL FLWRSFRSVRSRLYVGRE+KL
Sbjct: 10 VVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALM 69
Query: 82 LSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSE 141
LSGLIEEK KLLEKFSL+QKEYEGYEVESSL+DASFEK A E A+SLEATCEKLNRSNSE
Sbjct: 70 LSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATE-AQSLEATCEKLNRSNSE 128
Query: 142 LEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMS 201
LEDEILCLEK+LKEEKSKHS+QDELMADISK IQSLEDESKSLKSQ+AEAK+ K F+M+
Sbjct: 129 LEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMN 188
Query: 202 EERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLND 261
EER IAIKDALNENSQLQ S KQL Q EAEVWK QVSELNKQK+TFEDSKVHAEQVLND
Sbjct: 189 EERLKIAIKDALNENSQLQESQKQLLQ-EAEVWKEQVSELNKQKVTFEDSKVHAEQVLND 247
Query: 262 KENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHA 321
KE+HIKTLT L MKD AA+L ED TDDDNLELE+NS+ ENGA LD+P KGALKKLIHA
Sbjct: 248 KESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHA 307
Query: 322 AKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQ 381
AKLN SLK+LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FE+ENQKLQ
Sbjct: 308 AKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQ 367
Query: 382 QKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLE 441
QKLK+MTE YQENEMKL+RKLTVEENYR+E+EEKLS+V+EK+S ATE+LETYRK AKDLE
Sbjct: 368 QKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLE 427
Query: 442 EELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLE 501
EELERT+H YQ Q+IS+EK+ HDNWLAAR AERNL+DLRKENAHN+QKLTETELKFELLE
Sbjct: 428 EELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLE 487
Query: 502 KDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDPLGLSPVLPEGGGRGP 561
KDP ALDV NTAFGREH+P GP+PLG SSETRAFLSP TLLE PL LSP+LP GGGRG
Sbjct: 488 KDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGS 547
Query: 562 RGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSAL 621
RGPGNPLDHQITNERGE SCDRLTDPHRAPSDTGSLS P +QD +MMFPPPGQSYPDSAL
Sbjct: 548 RGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSAL 607
Query: 622 PPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPDSS 681
PPQR+DRF SNS RLSG AE RSF M SLDKMDGSMPSEMESSRND KDDLGNLNVPDSS
Sbjct: 608 PPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSS 667
Query: 682 LPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRD 741
LPAENEATGPGF+PPPLAP+RGPLFPVD RGPF+RRGPPFPPPPPG MFGASR YFPP D
Sbjct: 668 LPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGD 727
Query: 742 FPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNP 775
FPGPP APFAMRN+YPPRG PPY PRPGF+P P
Sbjct: 728 FPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPP 761
>gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]
Length = 775
Score = 1248 bits (3230), Expect = 0.0
Identities = 625/746 (83%), Positives = 672/746 (90%), Gaps = 2/746 (0%)
Query: 30 MRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEK 89
MRPD N YGFP ELV+CAAV+GFF VL FLWRSFRSVRSRLYVGRE+KL LSGLIEEK
Sbjct: 1 MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
Query: 90 CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCL 149
KLLEKFSL+QKEYEGYEVESSL+DASFEK A E A+SLEATCEKLNRSNSELEDEILCL
Sbjct: 61 SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATE-AQSLEATCEKLNRSNSELEDEILCL 119
Query: 150 EKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAI 209
EK+LKEEKSKHS+QDELMADISK IQSLEDESKSLKSQ+AEAK+ K F+M+EER IAI
Sbjct: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
Query: 210 KDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTL 269
KDALNENSQLQ S KQL Q EAEVWK QVSELNKQK+TFEDSKVHAEQVLNDKE+HIKTL
Sbjct: 180 KDALNENSQLQESQKQLLQ-EAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTL 238
Query: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329
T L MKD AA+L ED TDDDNLELE+NS+ ENGA LD+P KGALKKLIHAAKLN SLK
Sbjct: 239 TERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLK 298
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
+LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FE+ENQKLQQKLK+MTE
Sbjct: 299 TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTE 358
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVH 449
YQENEMKL+RKLTVEENYR+E+EEKLS+V+EK+S ATE+LETYRK AKDLEEELERT+H
Sbjct: 359 LYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIH 418
Query: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV 509
YQ Q+IS+EK+ HDNWLAAR AERNL+DLRKENAHN+QKLTETELKFELLEKDP ALDV
Sbjct: 419 SYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDV 478
Query: 510 SNTAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDPLGLSPVLPEGGGRGPRGPGNPLD 569
NTAFGREH+P GP+PLG SSETRAFLSP TLLE PL LSP+LP GGGRG RGPGNPLD
Sbjct: 479 PNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLD 538
Query: 570 HQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSALPPQREDRF 629
HQITNERGE SCDRLTDPHRAPSDTGSLS P +QD +MMFPPPGQSYPDSALPPQR+DRF
Sbjct: 539 HQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRF 598
Query: 630 YSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEAT 689
SNS RLSG AE RSF M SLDKMDGSMPSEMESSRND KDDLGNLNVPDSSLPAENEAT
Sbjct: 599 CSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEAT 658
Query: 690 GPGFIPPPLAPVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAP 749
GPGF+PPPLAP+RGPLFPVD RGPF+RRGPPFPPPPPG MFGASR YFPP DFPGPP AP
Sbjct: 659 GPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAP 718
Query: 750 FAMRNIYPPRGLPPYFHPRPGFYPNP 775
FAMRN+YPPRG PPY PRPGF+P P
Sbjct: 719 FAMRNVYPPRGFPPYLPPRPGFFPPP 744
>gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]
Length = 761
Score = 1215 bits (3143), Expect = 0.0
Identities = 618/775 (79%), Positives = 663/775 (85%), Gaps = 45/775 (5%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPG TPQPYLGL+LEELRRVVAALPE MRPD N YGFP ELV+CAAV+GFF VL FLW
Sbjct: 1 MEEPGVTPQPYLGLLLEELRRVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGRE+KL LSGLIEEK KLLEKFSL+QKEYEGYEVESSL+DASFEK
Sbjct: 61 RSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKE 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
A E A+SLEATCEKLNRSNSELEDEILCLEK+LKEEKSKHS+QDELMADISK IQSLEDE
Sbjct: 121 ATE-AQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDE 179
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
SKSLKSQ+AEAK+ K F+M+EER IAIKDALNENSQLQ S KQL Q EAEVWK QVSE
Sbjct: 180 SKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQ-EAEVWKEQVSE 238
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQK+TFEDSKVHAEQVLNDKE+HIKTLT L MKD AA+L ED TDDDNLELE+NS+
Sbjct: 239 LNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSE 298
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
ENGA LD+P KGALKKLIHAAKLN SLK+LEGERN I IQLSEVDKTKEELTEHIKNLQ
Sbjct: 299 SENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQ 358
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
T+QASLQSEN +FE+ENQKLQQKLK+MTE YQENEMKL+RKLTVEENYR+E+EEKLS+V+
Sbjct: 359 TEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVD 418
Query: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EK+S ATE+LETYRK AKDLEEELERT+H YQ Q+IS+EK+ HDNWLAAR AERNL+DLR
Sbjct: 419 EKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLR 478
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
KENAHN+QKLTETELKFELLEKDP ALDV NTAFG
Sbjct: 479 KENAHNRQKLTETELKFELLEKDPYALDVPNTAFG------------------------- 513
Query: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
RG RGPGNPLDHQITNERGE SCDRLTDPHRAPSDTGSLS P
Sbjct: 514 ------------------RGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPP 555
Query: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
+QD +MMFPPPGQSYPDSALPPQR+DRF SNS RLSG AE RSF M SLDKMDGSMPSE
Sbjct: 556 WDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSE 615
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
MESSRND KDDLGNLNVPDSSLPAENEATGPGF+PPPLAP+RGPLFPVD RGPF+RRGPP
Sbjct: 616 MESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPP 675
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNP 775
FPPPPPG MFGASR YFPP DFPGPP APFAMRN+YPPRG PPY PRPGF+P P
Sbjct: 676 FPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPP 730
>gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isoform
1 [Homo sapiens]
Length = 745
Score = 1144 bits (2960), Expect = 0.0
Identities = 583/744 (78%), Positives = 638/744 (85%), Gaps = 4/744 (0%)
Query: 30 MRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEK 89
MRPD +PYGFP ELV+ AAV GFF VL FLWRSFRSV SRLYV RE+K LSGLIEEK
Sbjct: 1 MRPDSHPYGFPWELVIRAAVAGFFAVL-FLWRSFRSVTSRLYVRREKKFAVALSGLIEEK 59
Query: 90 CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCL 149
CKLLEKFSL+QKEYEGYEVESSL++ASFEK A E A+SLEATCEKLNR NSEL EILCL
Sbjct: 60 CKLLEKFSLVQKEYEGYEVESSLKNASFEKEATE-AQSLEATCEKLNRFNSELVHEILCL 118
Query: 150 EKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAI 209
EK+LKEEKSKHS+Q+ELMADISK IQSLEDESKSLKSQ+AEAK+ K F+ +EER I I
Sbjct: 119 EKELKEEKSKHSEQNELMADISKRIQSLEDESKSLKSQVAEAKMTFKRFQANEERLEIEI 178
Query: 210 KDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTL 269
+DA ENS+LQ S KQL Q EAEVWK QVSEL KQK TFEDSKVHAEQVLNDKENHIKTL
Sbjct: 179 QDAWKENSELQESQKQLLQ-EAEVWKEQVSELIKQKRTFEDSKVHAEQVLNDKENHIKTL 237
Query: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329
T L MKD A+LEED TDDDNLELE+NS+ E+GA LD+P KGALKKLIHAAKLN SLK
Sbjct: 238 TERLLKMKDGVAMLEEDVTDDDNLELEMNSESEDGAYLDNPPKGALKKLIHAAKLNASLK 297
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
+LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FESENQKLQQKLK+MTE
Sbjct: 298 TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFESENQKLQQKLKVMTE 357
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVH 449
YQENEMKLYRKL VEE R+E+EEKLS+V+E +S ATE+LETYRK AKDL+E E+T+H
Sbjct: 358 LYQENEMKLYRKLIVEEKCRLEKEEKLSKVDEMISHATEELETYRKRAKDLKE-FEKTIH 416
Query: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV 509
FYQK++I +EK+ HDNW AA TAERNL+DLRKENAHN+QKLTE E K +LLEKDP LDV
Sbjct: 417 FYQKKIILHEKKAHDNWSAAWTAERNLNDLRKENAHNRQKLTEIEFKIKLLEKDPYGLDV 476
Query: 510 SNTAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDPLGLSPVLPEGGGRGPRGPGNPLD 569
NTAFGR+H+P GP+PLG SSETRA L P TLLE PL LSP+LP GGGRG RGPGNP D
Sbjct: 477 PNTAFGRQHSPYGPSPLGWPSSETRASLYPPTLLEGPLRLSPLLPRGGGRGSRGPGNPPD 536
Query: 570 HQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSALPPQREDRF 629
HQIT ERGE SCDRLTDPHRAPSD G L+ P EQD +MMFPPPGQSYPDSALPPQR+DRF
Sbjct: 537 HQITKERGESSCDRLTDPHRAPSDAGPLAPPWEQDYRMMFPPPGQSYPDSALPPQRQDRF 596
Query: 630 YSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEAT 689
YSN RLSG AE RSF M SLDKMDGSMPSEMESSRND KD+LGNL VPDSSLPAENEAT
Sbjct: 597 YSNCARLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDNLGNLKVPDSSLPAENEAT 656
Query: 690 GPGFIPPPLAPVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAP 749
GPGF+PPPLAP+RG LFPVDTRGPF+RRGPPFPPPPPGT+FGAS YF PRD PGPP AP
Sbjct: 657 GPGFVPPPLAPIRGLLFPVDTRGPFIRRGPPFPPPPPGTVFGASPDYFSPRDVPGPPRAP 716
Query: 750 FAMRNIYPPRGLPPYFHPRPGFYP 773
FAMRN+Y PRG PY PRP F+P
Sbjct: 717 FAMRNVYLPRGFLPYRPPRPAFFP 740
>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
sapiens]
Length = 1907
Score = 242 bits (618), Expect = 8e-64
Identities = 217/789 (27%), Positives = 368/789 (46%), Gaps = 103/789 (13%)
Query: 20 RRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLG 79
+ +VA LP+ ++P + YG P + V A +G +FLWR+ V+ R+Y EQ++
Sbjct: 1158 KSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQIS 1217
Query: 80 ATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAA-AEEARSLEATCEKLNRS 138
L +++E +L++K S +++ + E + +++ + ++EA + + L ++
Sbjct: 1218 EKLKTIMKENTELVQKLSNYEQKIK--ESKKHVQETRKQNMILSDEAIKYKDKIKTLEKN 1275
Query: 139 NSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
L+D L L+ E+ ++ + +L+++ KSI+ L+D S+ +E +I
Sbjct: 1276 QEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEA 1335
Query: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQV 258
K+SEE+ EN++L+ +QL QQE E W +EL++Q +FE S+ E
Sbjct: 1336 KLSEEKVKSECHRVQEENARLKKKKEQL-QQEIEDWSKLHAELSEQIKSFEKSQKDLEVA 1394
Query: 259 LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL 318
L K+++I LT + + E + + + + + E G + ++ +K +K++
Sbjct: 1395 LTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQM 1454
Query: 319 IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQ 378
+ ++ ++ +E + + ++L TK L + +K L+ + SLQ+ E E +
Sbjct: 1455 MDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECK 1514
Query: 379 KLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAK 438
L+QK++I+ E YQ+ EM L +KL+ EE R E E +LS +EK A E+++TY++ +
Sbjct: 1515 TLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIE 1574
Query: 439 DLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFE 498
++E+EL++T ++ Q+ ++EK+ H+NWL AR AER +++ ++E A+ + KL E K
Sbjct: 1575 EMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMA 1634
Query: 499 LLEKDPNALDVSNTAFGREHAPNGP--APLGQRSSETRAFLSPQTLLEDPLGLSPVLPEG 556
+L+++P + G+ + N P PL Q S G SPV G
Sbjct: 1635 MLQEEP---VIVKPMPGKPNTQNPPRRGPLSQNGS---------------FGPSPV--SG 1674
Query: 557 GGRGP----RGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPP 612
G P P PL + N R P S+ GS+ P+ P P
Sbjct: 1675 GECSPPLTVEPPVRPLSATL-NRRDMPR-----------SEFGSVDGPL--------PHP 1714
Query: 613 GQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDL 672
S S P S S+ SG+A M S + GS P+ + D
Sbjct: 1715 RWSAEASGKP--------SPSDPGSGTAT----MMNSSSR--GSSPTRVL--------DE 1752
Query: 673 GNLNV------PDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRR--GPPFPP- 723
G +N+ P +P + G G +PPP+ GP P GPF R PPF P
Sbjct: 1753 GKVNMAPKGPPPFPGVPLMSTPMG-GPVPPPIR--YGP--PPQLCGPFGPRPLPPPFGPG 1807
Query: 724 --PP-------PGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPR-------GLPPYFHP 767
PP PG G PR F P HAPF PR LPP H
Sbjct: 1808 MRPPLGLREFAPGVPPGRRDLPLHPRGFL-PGHAPFRPLGSLGPREYFIPGTRLPPPTHG 1866
Query: 768 RPGFYPNPA 776
+ P PA
Sbjct: 1867 PQEYPPPPA 1875
Score = 30.0 bits (66), Expect = 8.6
Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 24/163 (14%)
Query: 314 ALKKLIHAAKLNVSL-KSLEGERNHIIIQLSEVDKTKEELTE----------HIKNLQTQ 362
A++K + + N L K E E + E D E TE H + +Q
Sbjct: 157 AVEKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQ 216
Query: 363 QASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEEN----YRIEEEEKLSR 418
Q E FES + LQ KLK+ + N+ +++ E++ Y++ ++E
Sbjct: 217 ANHAQGEQASFESFEEMLQDKLKVPES--ENNKTSNSSQVSNEQDKIDAYKLLKKEMTLD 274
Query: 419 VEEKLSRATEQL----ETYR---KLAKDLEEELERTVHFYQKQ 454
++ K + L ET R L D +EEL+ + K+
Sbjct: 275 LKTKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKE 317
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 82.0 bits (201), Expect = 2e-15
Identities = 89/395 (22%), Positives = 178/395 (45%), Gaps = 44/395 (11%)
Query: 74 REQKL---GATLSGLIEEKCKLLEKFSLIQKEYEGYEV--ESSLEDASFEKAAAEEARSL 128
+EQK+ T++ L E + +L ++ +QK + E+ + + + A+ R +
Sbjct: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLM 1169
Query: 129 EATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI 188
+ +KL N+++ED LE+++K +K K E + + S+Q E+++ +K +
Sbjct: 1170 KELNQKLTNKNNKIED----LEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLL 1225
Query: 189 AEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHK---QLFQQEAEVWKGQVSELNKQK 245
+ K + K A ++ LQ S K + QQ+ EV+K Q++E
Sbjct: 1226 VKTK-----------KELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE----- 1269
Query: 246 ITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGA 305
IT E K+H E + E H +TL+ + + + L+E+ + V S++E
Sbjct: 1270 ITSEKHKIH-EHLKTSAEQHQRTLSAY----QQRVTALQEECRAAKAEQATVTSEFE--- 1321
Query: 306 NLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQAS 365
+ + LK+ + + + + ER H+ + +D+ K +L + NLQ +
Sbjct: 1322 SYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEML---IDQLKIKLQDSQNNLQINVSE 1378
Query: 366 LQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKL-TVEENYRIEEEEKLSRVEEKLS 424
LQ+ +SE+ L ++ M + E +L KL +++ + + E V + S
Sbjct: 1379 LQT----LQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTS 1434
Query: 425 RATEQLETYRKLAKDLEEELERTVHFYQKQVISYE 459
+ ++R + L+EE +TV Q+Q+ E
Sbjct: 1435 QNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKME 1469
Score = 69.3 bits (168), Expect = 1e-11
Identities = 101/452 (22%), Positives = 192/452 (42%), Gaps = 70/452 (15%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKL 135
Q +G +L+ + EEKC L Q++ + E+E + K EE+ CE+L
Sbjct: 784 QAVGESLAKINEEKCNLA-----FQRDEKVLELEKEI------KCLQEES---VVQCEEL 829
Query: 136 NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
+ E E + L K+L+E +S+ + ++ + + E+++L Q+ E C
Sbjct: 830 KSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHA 255
++ E+ IK+ +EN + K+L + AE+ I +DS +
Sbjct: 890 SKSEIHNEKEKCFIKE--HENLKPLLEQKELRDRRAEL------------ILLKDSLAKS 935
Query: 256 EQVLNDKENHIKTLTGHLPMMKDQ-------------AAVLEEDTTDDDNLELE-VNSQW 301
V ND + +K L + ++ + AV + D E + V +
Sbjct: 936 PSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEEL 995
Query: 302 ENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTK--------EELT 353
E+ + D L +++ LI A+ S K+L E QL +V+K + E+LT
Sbjct: 996 ESLRSEKDQLSASMRDLIQGAE---SYKNLLLEYEKQSEQL-DVEKERANNFEHRIEDLT 1051
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
++N Q ++ S+N + + LQ K++ E + K V++ E+
Sbjct: 1052 RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR---AKAMVDKELEAEKL 1108
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAE 473
+K +++E + E E +L K+ +++L++T+ Q + K+ A +T
Sbjct: 1109 QKEQKIKEHATTVNELEELQVQLQKE-KKQLQKTM-----QELELVKKD-----AQQTTL 1157
Query: 474 RN--LSDLRKENAHNKQKLTETELKFELLEKD 503
N ++D + QKLT K E LE++
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQE 1189
Score = 60.8 bits (146), Expect = 5e-09
Identities = 88/446 (19%), Positives = 193/446 (43%), Gaps = 64/446 (14%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKL 135
++L ++ L EEK + K +E + + + E E+ E + +E T +
Sbjct: 583 KELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE----ERLILELGKKVEQTIQY- 637
Query: 136 NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
NSELE ++ L L+E + Q D+ + + ++ L ++ + L +++
Sbjct: 638 ---NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV------- 687
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQ--------LFQQEAEVWKGQVSELNKQKIT 247
K EN++L + KQ L Q+E + K +++L K+
Sbjct: 688 --------------KSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 733
Query: 248 FEDSKVHAEQVL-NDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
+ + + ++L N++ + T +K+ + + ED+ + D + + + + E+ A
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNV-LQAVGESLAK 792
Query: 307 L-DDPLKGALKKLIHAAKLNVSLKSLEGER----NHIIIQLSEVDKTKEELTEHIKNLQT 361
+ ++ A ++ +L +K L+ E + L + ++ K L + ++ +Q+
Sbjct: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQS 852
Query: 362 QQASLQSENIYFESENQKLQ---QKLKIMTEFYQE--NEMKLYRKLTVEENYRIEEEEKL 416
++ +LQS+ + ++ N+K + Q L I E + ++ +++ + +E I+E E L
Sbjct: 853 EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNE---KEKCFIKEHENL 909
Query: 417 SRV---EEKLSRATEQLETYRKLAKDLE---------EELERTVHFYQKQVISYEKRGHD 464
+ +E R E + LAK +ELE + +K+ E++ +
Sbjct: 910 KPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINK 969
Query: 465 NWLAARTAERNLSDLRKENAHNKQKL 490
L A A++ L RKE K++L
Sbjct: 970 IKLVAVKAKKELDSSRKETQTVKEEL 995
Score = 54.3 bits (129), Expect = 4e-07
Identities = 98/457 (21%), Positives = 195/457 (42%), Gaps = 71/457 (15%)
Query: 77 KLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLN 136
KL L+++ C+ EK IQK+YE LE+ + A A C L
Sbjct: 272 KLNELKENLVKQ-CEASEKN--IQKKYE-----CELENL---RKATSNANQDNQICSILL 320
Query: 137 RSNSELE----DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI---- 188
+ N+ +E +++ LE LKE +S+HS + + ++ LE +++ +K +
Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHER 380
Query: 189 AEAKIICKTFKMSEERRAIAIKDALNENSQLQ-------TSHKQLFQQEAEVWKGQVSEL 241
+ + +++E + I+ +E + L H + Q E + ++SEL
Sbjct: 381 EDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL 440
Query: 242 NKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQW 301
N E L+D E TL + +K+Q L+++ + E +
Sbjct: 441 N-------------ETFLSDSEKEKLTLMFEIQGLKEQCENLQQE-------KQEAILNY 480
Query: 302 ENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKT----KEELTEHIK 357
E+ + + L+ L + A K++ +S++ ++ + +L + +T K+ L E +
Sbjct: 481 ESLREIMEILQTELGE--SAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVN 538
Query: 358 NLQTQQASLQS-ENIYFESEN--QKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEE 414
LQ + L S + + E EN + LQ+K + + + L ++L + N EE++
Sbjct: 539 RLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTML-KELEGKINSLTEEKD 597
Query: 415 ----KLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAAR 470
KL E++ ++ E +L +L +++E+T+ + + E N L
Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY------NSELEQKVNELTG- 650
Query: 471 TAERNLSDLRKENAHNKQKLTETELKFELLEKDPNAL 507
L + KE N QKL + ++ ++L +D L
Sbjct: 651 ----GLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVL 683
Score = 47.4 bits (111), Expect = 5e-05
Identities = 61/300 (20%), Positives = 130/300 (43%), Gaps = 24/300 (8%)
Query: 149 LEKDLKEEKSKHSQQDELMADISKS-IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAI 207
LE KE+ K +++ ++ +KS LE E + L+S+ ++E A+
Sbjct: 22 LETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDAL 81
Query: 208 AIKDALNENSQLQTSHKQL-FQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHI 266
++ A E L + + +QE E ++ + +K+ E S ++ + + + +N +
Sbjct: 82 LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE---LEQSHINYVKEIENLKNEL 138
Query: 267 KTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNV 326
+ + A L++ + N +LE++ Q + N +D +K KL
Sbjct: 139 MAVRSKY---SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVK----------KLQE 185
Query: 327 SLKSLE-GERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLK 385
++ + G I+ ++D T +E E + LQ +++ + +++ LQ++L
Sbjct: 186 EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQN---IIEANSQHYQKNINSLQEELL 242
Query: 386 IMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELE 445
+ +QE +L ++ E KL+ ++E L + E E + + K E ELE
Sbjct: 243 QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASE--KNIQKKYECELE 300
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 80.1 bits (196), Expect = 7e-15
Identities = 100/441 (22%), Positives = 191/441 (43%), Gaps = 32/441 (7%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSL-IQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEK 134
+K TL E + K+LE+ + + + S + + K +E + L + ++
Sbjct: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598
Query: 135 LNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKII 194
+ S++E E ++K+L+ K K + +EL + LE E++ L+ +I KI
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEEL----ENELHHLEKENELLQKKITNLKIT 654
Query: 195 CKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEA-EVWKGQVSELNKQKITFEDSKV 253
C+ + E+ + ++ L + FQ E+ E Q+ E N + +S
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Query: 254 HAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKG 313
A + + K L +K +L+ + LE+ L L+
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 314 ALKKLIHAAKLNVSLKSLEGERNHIIIQLSEV---DKTKEELTEHIKNLQTQQASLQSEN 370
+ KK+ +L L+ LE E + L E+ K E+L + K+L+ + + L+ +
Sbjct: 775 SNKKI---QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 371 IYFESENQKLQQKLKIMTEFYQENEMK----------LYRKLTV--EENYRIEEEEKLSR 418
E EN++L+Q+ +I +EN +K L +++ + E R++E EK ++
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 419 VEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSD 478
E + RAT ++T L +DL E +T Q+ EK H+ ER L D
Sbjct: 892 --ELVKRATIDIKTLVTLREDLVSEKLKT----QQMNNDLEKLTHELEKIGLNKERLLHD 945
Query: 479 LRKENAHNKQKLTETELKFEL 499
+++ ++ KL E++L+ L
Sbjct: 946 --EQSTDDRYKLLESKLESTL 964
Score = 80.1 bits (196), Expect = 7e-15
Identities = 119/501 (23%), Positives = 202/501 (40%), Gaps = 82/501 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAA----EEARSLE 129
+ ++L + GL E +L + K+ + ++ES L+D E EE +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQ--QLESELQDLEMENQTLQKNLEELKISS 807
Query: 130 ATCEKLNRSNSELEDEILCLEKDLK--EEKSKHSQQ-----DELMADISKSIQSLEDESK 182
E+L + N LE E LEKD K E+++K +Q D + + + I +LE E+K
Sbjct: 808 KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Query: 183 SLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELN 242
+L +I K C K E+ +K A + L T + L +E K Q +
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV---SEKLKTQQMNND 924
Query: 243 KQKITFEDSKV--------HAEQVLNDKENHIK-----TLTGHLPMMKDQAAV----LEE 285
+K+T E K+ H EQ +D+ ++ TL L + +++ A LEE
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 984
Query: 286 DTTDDDNLELEVNSQWENGANL------------DDPLKGALKKLIHAAK------LNVS 327
T + L E+ + +N L P+ G K ++ L V
Sbjct: 985 STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044
Query: 328 LKSLEGERNHIII---------QLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQ 378
+ +E ERN+ + QL +++ L I LQ Q SLQ +N +++N
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104
Query: 379 KLQQKLKIM----TEFYQENEMKLYRKLTVEENYR--IEEEEKLSRVEEKLSRATEQLET 432
KLQ + + T +N L ++ ++E I+E E L + + L + E+LE
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL 1164
Query: 433 YRKLAKDLEEELERTVHFYQKQVISYE--KRGHDNWLAARTAERNLSDLRKENAHNKQKL 490
ER Y+ + + K H N R+L D + K +L
Sbjct: 1165 LH----------ERQASEYESLISKHGTLKSAHKN---LEVEHRDLEDRYNQLLKQKGQL 1211
Query: 491 TETELKFELLEKDPNALDVSN 511
+ E K +E++ L+ N
Sbjct: 1212 EDLE-KMLKVEQEKMLLENKN 1231
Score = 75.1 bits (183), Expect = 2e-13
Identities = 91/410 (22%), Positives = 176/410 (42%), Gaps = 34/410 (8%)
Query: 124 EARSLEATCEKLNRSNSELE---DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
E +SL T E+L + +E +IL +EK+ + K + + +S+Q+ ++
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
SK L + A+ + +T + + ER+ ++ +Q +S +Q Q AE + +
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 241 LNK-------------QKITFEDSKVHAE-QVLNDKENHIKTLTGHLPMMKDQAAVLEED 286
NK KI FE ++ E + +K + L L ++ + +L++
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 287 TTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVD 346
T+ ++ + + + L+ + K L L L+SLE E + QL E +
Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEEN 703
Query: 347 KTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEM--KLYRKLTV 404
E +K + A LQ EN ESE ++L++ L+++ +++ E Y+ L +
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 405 EENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHD 464
EN R+ ++ L +K+ + +L+ + L++ LE + K++ EK
Sbjct: 764 -ENQRL--QKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSKRLEQLEKENKS 819
Query: 465 NWLAARTAERNLSDLRKENAHNKQK-------LTETELKFELLEKDPNAL 507
E++ L KEN +Q+ L E +K LEK+ L
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Score = 60.5 bits (145), Expect = 6e-09
Identities = 81/388 (20%), Positives = 175/388 (45%), Gaps = 41/388 (10%)
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
K S L E+ + ++ + + ++ E + D + ++ +E E K L+ +
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 194 ICKTFKM-SEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSK 252
++ +M +E A+ K + + + S + + E +K +V EL + ++K
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 253 VHAEQVLN------------DKEN-HIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNS 299
E L +KEN +K + M +D E+ ++ N+ LE+
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE-NMTLEMAQ 419
Query: 300 QWENGANLDDPLKGALKKLIHAAKLNVS-LKSLEGERNHIII-QLSEVDKTKEELTEHIK 357
+ +L L L+++ ++L+ + KSL E N + +L +++ + LT+ ++
Sbjct: 420 KQSMDESLH--LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 358 NLQTQQASLQ---SENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEE 414
L+T S++ S+ + E ENQ+L +K++I+ ENE+ V+E ++ +
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEIL-----ENEI-------VQEKQSLQNCQ 525
Query: 415 KLSR-VEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAE 473
LS+ + ++ ++ + +ET R+ ++ + LE+ + V S +R + +AE
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR------SQISAE 579
Query: 474 RNLSDLRKENAHNKQKLTETELKFELLE 501
+ D+ KEN + + ET K +E
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIE 607
Score = 56.2 bits (134), Expect = 1e-07
Identities = 95/465 (20%), Positives = 193/465 (41%), Gaps = 69/465 (14%)
Query: 74 REQKLGATLSGLIEEKC----KLLEKFSLIQKEYEGYE--------VESSL----EDASF 117
+E+K+ A L +EE +L ++ ++K YE + V+SS ED +
Sbjct: 971 KEEKIAA-LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW 1029
Query: 118 EKAAAEEARSLEATCEKL---NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSI 174
E+ + E R L ++L R+N+ L+ E L+ LK+ +++++ + + +
Sbjct: 1030 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1089
Query: 175 QSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV- 233
SL++++ +L++Q A+ ++ T L + S L+ ++ + ++ ++
Sbjct: 1090 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1149
Query: 234 --WKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD 291
+ + + K ++ E E +++ G L V D D
Sbjct: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKH--------GTLKSAHKNLEVEHRDLEDRY 1201
Query: 292 NLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSL----KSLEGERNHIIIQLSEVDK 347
N L+ Q E+ L+ LK +K++ K + ++ K L GE + + S++ K
Sbjct: 1202 NQLLKQKGQLED---LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1258
Query: 348 TKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIM--TEFYQENEMKLYRKL--- 402
E L KNL++ + + E E+E KL+++ + + T N+ +L +L
Sbjct: 1259 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1318
Query: 403 TVEENYRI------------------EEEEKLSRVEEKLSRATEQLETYRKLAKDLEEEL 444
EEN + E + L VE++ + ++L R+ + LEE++
Sbjct: 1319 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR--QYIDKLNELRRQKEKLEEKI 1376
Query: 445 ERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQK 489
FY R NW+ + R L +K+ +QK
Sbjct: 1377 MDQYKFYDPS----PPRRRGNWITLKM--RKLIKSKKDINRERQK 1415
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 79.7 bits (195), Expect = 9e-15
Identities = 105/456 (23%), Positives = 198/456 (43%), Gaps = 50/456 (10%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEK--------AAAEEARSLEATCEKLN 136
L++E L + S + +YE V +LE A EK + EE L EKL
Sbjct: 2068 LVKESESLQARLS--ESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
Query: 137 RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICK 196
E + L + + LKE + ++ + + ++ + +Q E+ + + +K +
Sbjct: 2126 VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVE 2185
Query: 197 TFKMSEERRAIAIK----DALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFE--- 249
T K E A ++K D + S+ + KQ+ +++ GQ+SEL+K +F+
Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ-----GQLSELDKLLSSFKSLL 2240
Query: 250 DSKVHAE-QVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLD 308
+ K AE Q+ + + ++ L L + + A L D E+ E +LD
Sbjct: 2241 EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ--------EIMKATEQ--SLD 2290
Query: 309 DPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQ--ASL 366
P++ + KL L++ E ++ ++ QL E + + L ++NL+ + A
Sbjct: 2291 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIART 2350
Query: 367 QSENIYFESENQK-----LQQKLKIMTEFYQENEMKLYRKLTVEENYRIE---EEEKLSR 418
E+ E+EN K L+ K++ MT+ + E+ + + +EN E E+E++S
Sbjct: 2351 NQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISE 2410
Query: 419 VEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRG---HDNWLAARTAERN 475
+E S L+ + ++E+ + Q Q+ +R H++ A + E+N
Sbjct: 2411 LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN 2470
Query: 476 LSD----LRKENAHNKQKLTETELKFELLEKDPNAL 507
LS L E A Q L E + + +L+ N L
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
Score = 58.5 bits (140), Expect = 2e-08
Identities = 90/436 (20%), Positives = 184/436 (42%), Gaps = 54/436 (12%)
Query: 72 VGREQKLGATLSGLIE-------EKCKLLEKFSLIQKEYEGYEVESSLED-----ASFEK 119
VG +K + LS +E E + +E + + E + +SS ED A
Sbjct: 1832 VGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND 1891
Query: 120 AAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED 179
+ E +E ++ + +E E L LE DL+ +++ ++ + K I LE+
Sbjct: 1892 SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE 1951
Query: 180 ESKSLKSQIAEAKIICKTFKMSEERRAI-AIKDALNENSQLQTSHKQLFQQEAEVWKGQV 238
E + S+ + + T MS++ A+ + + + E +Q SH+ +V + +V
Sbjct: 1952 ELSVVTSERNQLRGELDT--MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
Query: 239 SELNKQKITFED-------SKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEED----T 287
E + T K H ++ L E + L+ +++Q A L ++
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069
Query: 288 TDDDNLELEVNSQWENGANLDDPLKGAL-------------KKLIH-----AAKLNVSLK 329
+ ++L+ ++ N+ L+ AL ++ +H KL V ++
Sbjct: 2070 KESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIE 2129
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNL--QTQQASLQSENIYFESENQK-----LQQ 382
+ E ++ HI +L E ++ + L + ++NL + Q + E + ++EN K L+
Sbjct: 2130 ADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT 2189
Query: 383 KLKIMTEFYQENEMKLYRKLTVEENYRIEEEEK---LSRVEEKLSRATEQLETYRKLAKD 439
+++ M + E+ L + +EN + +EK LS +++ LS LE +
Sbjct: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Query: 440 LEEELERTVHFYQKQV 455
++EE + V Q Q+
Sbjct: 2250 IKEESKTAVEMLQNQL 2265
Score = 57.4 bits (137), Expect = 5e-08
Identities = 106/531 (19%), Positives = 216/531 (40%), Gaps = 105/531 (19%)
Query: 59 LWRSFRSVRSRLYVGREQKL--GATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDAS 116
L R +R R+ +++L L E L +K +++E + E L
Sbjct: 2117 LRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILD 2176
Query: 117 FEKAAAEEARSLEATCEKLNRSNSELEDEILCLE-------KDLKEEKSKHSQQDELMAD 169
E + AE +L+ E++ RS E +++ L K ++E++ + S+ D+L++
Sbjct: 2177 AENSKAE-VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS 2235
Query: 170 ISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIA---------------IKDALN 214
++ E +K + A + + ++ E A+A + +
Sbjct: 2236 FKSLLEEKEQAEIQIKEESKTAVEMLQN-QLKELNEAVAALCGDQEIMKATEQSLDPPIE 2294
Query: 215 ENSQLQTSHKQL--------------------FQQEAEVWKGQVSELNKQKITFEDSKVH 254
E QL+ S ++L + A++ KG+V L ++ ++ H
Sbjct: 2295 EEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH 2354
Query: 255 AEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT----TDDDNL------------ELEV- 297
A + + ++TL + M LE D ++ +NL ELE+
Sbjct: 2355 AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEII 2414
Query: 298 NSQWENGANLDDPLKGALKKLIHAAK--LNVSLKSLEGERNHIIIQLSEVDKTKEE-LTE 354
NS +EN + K +K+ A L LK L ER + E K KE+ L+
Sbjct: 2415 NSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELN-ERVAALHNDQEACKAKEQNLSS 2473
Query: 355 HIKNLQTQQASL-----QSENIYF-------------ESENQKLQQK------------- 383
++ L+ ++A L +++N Y E QKL++K
Sbjct: 2474 QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD 2533
Query: 384 -LKIMTEFYQ-ENEMKLYRKLTVE-ENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDL 440
+++++ Q E E +L+++ +E N +E E+K+ ++ K + + LE + K+L
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593
Query: 441 EEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLT 491
E ELE T + +S+ ++ + +R + ++ ++ A +++L+
Sbjct: 2594 ENELELT----KMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELS 2640
Score = 53.9 bits (128), Expect = 6e-07
Identities = 86/381 (22%), Positives = 161/381 (42%), Gaps = 49/381 (12%)
Query: 107 EVESSLEDASFE-KAAAEEARSLEATCEKLNRSNSELED---EILCLEKDLKEEKSKHSQ 162
E S+LE+ E + ++ + +A ++L +SN LED E+ L + L EK + S
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMS- 959
Query: 163 QDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTS 222
+++ + I+ L E+ +LK I +LN+
Sbjct: 960 --SIISLNKREIEELTQENGTLKE----------------------INASLNQEKMNLIQ 995
Query: 223 HKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAV 282
+ F + + +SEL+ Q ++ K+ Q + N + L+ K +AA
Sbjct: 996 KSESFANYIDEREKSISELSDQ---YKQEKLILLQRCEETGNAYEDLS-----QKYKAA- 1046
Query: 283 LEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQL 342
+E + + L E S EN N + LK A K + L E +++++L
Sbjct: 1047 -QEKNSKLECLLNECTSLCENRKNELEQLKEAFAK--EHQEFLTKLAFAEERNQNLMLEL 1103
Query: 343 SEVDKT-KEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRK 401
V + + E+T++ N +++ L+ E + + E K+Q K + + QENE +
Sbjct: 1104 ETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQ---KEVNDLLQENEQLMKVM 1160
Query: 402 LTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKR 461
T E +E E + V+E R +E+ + K DLE + E ++ Y Q++ E
Sbjct: 1161 KTKHECQNLESEPIRNSVKE---RESERNQCNFKPQMDLEVK-EISLDSYNAQLVQLEAM 1216
Query: 462 GHDNWLAARTAERNLSDLRKE 482
+ L + +E+ L+ E
Sbjct: 1217 LRNKELKLQESEKEKECLQHE 1237
Score = 52.8 bits (125), Expect = 1e-06
Identities = 88/433 (20%), Positives = 183/433 (42%), Gaps = 54/433 (12%)
Query: 85 LIEEKCKLLEKFSLIQK-EYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELE 143
L + K +L+EK ++ K E + + AS + A E+ L+ E L+ E
Sbjct: 322 LEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ--KLKKLTEDLSCQRQNAE 379
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFK---M 200
LE+ +KE++ + Q+EL +S Q+L+ E +K+++ + K
Sbjct: 380 SARCSLEQKIKEKEKEF--QEELSRQ-QRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 201 SEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKV------- 253
+E + ++K L N L+ ++L + E Q+ E N+ + + E+ K
Sbjct: 437 AELDKLTSVKQQLENN--LEEFKQKLCRAEQAFQASQIKE-NELRRSMEEMKKENNLLKS 493
Query: 254 HAEQVLNDK---ENHIKTLTGHLPMMKDQAAVLEEDTTDDD----NLELEVNSQWENGAN 306
H+EQ + E +K + L ++ A ++ T + +L+ ++N Q EN
Sbjct: 494 HSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ-ENSLT 552
Query: 307 LDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASL 366
L+ KL +++ LE +R+ L + + E+L + + + + +L
Sbjct: 553 LE--------------KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
Query: 367 QSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRA 426
S + E ++L+++ + + + ENE L + + +EN + K++ +E L
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL----QSKINHLETCLKTQ 654
Query: 427 TEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHN 486
+ Y + + LE + E +S E R N L +++ E L
Sbjct: 655 QIKSHEYNERVRTLEMDREN---------LSVEIRNLHNVLDSKSVEVETQKLAYMELQQ 705
Query: 487 KQKLTETELKFEL 499
K + ++ + + E+
Sbjct: 706 KAEFSDQKHQKEI 718
Score = 50.4 bits (119), Expect = 6e-06
Identities = 89/439 (20%), Positives = 178/439 (40%), Gaps = 62/439 (14%)
Query: 126 RSLEATCEKLNRSNSELED----------EILCLEKDLKEEKSKHSQQDELMADISKSIQ 175
+ +E C K ++ ++ED EI+ ++ ++ +++ +L+ S+
Sbjct: 716 KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775
Query: 176 SLEDESKSLKSQIAE-------AKIICKTFKMSEERRAIAIK-DALNENSQLQTSHKQLF 227
+ ED +SL + + A II + M ER ++ D +NS + +
Sbjct: 776 TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
Query: 228 QQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT 287
+ E K S+L KQ K E+ L E ++ + + L+EDT
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAET---SQRISKLQEDT 892
Query: 288 TDDDNLELEVNSQWENGAN----LDDPLKGALKKLIHAAKLNVSLK-------------S 330
+ N+ E S EN L+D ++ ++ K N L+ S
Sbjct: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLS 952
Query: 331 LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSE--NIYFESEN-----QKLQQK 383
LE + II L++ + EELT+ L+ ASL E N+ +SE+ + ++
Sbjct: 953 LEKKEMSSIISLNK--REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKS 1010
Query: 384 LKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEE 443
+ +++ Y++ ++ L ++ N + +K +EK S+ L L ++ + E
Sbjct: 1011 ISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNE 1070
Query: 444 LERTVHFYQKQVISY-------EKRGHDNWLAARTAERNLSDLRKENAHN--------KQ 488
LE+ + K+ + E+R + L T ++ L +N +N KQ
Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130
Query: 489 KLTETELKFELLEKDPNAL 507
++ + + ++K+ N L
Sbjct: 1131 EIMTLKEEQNKMQKEVNDL 1149
Score = 47.0 bits (110), Expect = 7e-05
Identities = 74/369 (20%), Positives = 151/369 (40%), Gaps = 41/369 (11%)
Query: 138 SNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKT 197
S S+ ED K+++E K ++ L A K+ Q+L + + + IA +
Sbjct: 160 SGSKYEDLKEKYNKEVEERKRLEAEVKALQA--KKASQTLPQATMNHRD-IARHQASSSV 216
Query: 198 FKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQ 257
F +E+ L+ NSQ + A + G+ E+ + T + K A
Sbjct: 217 FSWQQEKTP----SHLSSNSQRTPIRRDF---SASYFSGE-QEVTPSRSTLQIGKRDANS 268
Query: 258 VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKK 317
D + P + DQ ++ + N ELE+ Q + +KG + K
Sbjct: 269 SFFDNSSS--------PHLLDQLKAQNQELRNKIN-ELELRLQGH-----EKEMKGQVNK 314
Query: 318 L----IHAAKLNVSL----KSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ--TQQASLQ 367
+ K V L K L R+ ++ ++ D+ + T + L+ T+ S Q
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374
Query: 368 SENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRAT 427
+N ES L+QK+K + +QE + R + I+ + +L++ ++
Sbjct: 375 RQNA--ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
Query: 428 EQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKEN---- 483
L+ ++++LE + +++++ E+ + + R++ +++KEN
Sbjct: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
Query: 484 AHNKQKLTE 492
+H++QK E
Sbjct: 493 SHSEQKARE 501
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/363 (20%), Positives = 145/363 (39%), Gaps = 87/363 (23%)
Query: 71 YVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEA 130
+V + K+ A + L E ++ +K + +Q+E G + + E + EE +S +
Sbjct: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE----LQLLLEEIKSSKD 2662
Query: 131 TCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAE 190
++L NSEL+ + C+ KD E++ K ++ +IAE
Sbjct: 2663 QLKELTLENSELKKSLDCMHKDQVEKEGK------------------------VREEIAE 2698
Query: 191 AKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFED 250
++ + + ++ +A+ + ++QT ++L +E L+ QK+ +
Sbjct: 2699 YQL--RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKE--------ECLSSQKLEIDL 2748
Query: 251 SKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEE-DTTDDDNLELEVNSQWENGANLDD 309
K E++ N +K +LEE T DNL+ + EN +
Sbjct: 2749 LKSSKEELNNS--------------LKATTQILEELKKTKMDNLKYVNQLKKEN-----E 2789
Query: 310 PLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSE 369
+G +K LI + K ++++ KE L + + LQ Q Q
Sbjct: 2790 RAQGKMKLLIKSCK--------------------QLEEEKEILQKELSQLQAAQEK-QKT 2828
Query: 370 NIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQ 429
+++ +L ++K + E +E T E + +++ L EKL +A E
Sbjct: 2829 GTVMDTKVDELTTEIKELKETLEEK--------TKEADEYLDKYCSLLISHEKLEKAKEM 2880
Query: 430 LET 432
LET
Sbjct: 2881 LET 2883
Score = 39.3 bits (90), Expect = 0.014
Identities = 81/387 (20%), Positives = 150/387 (38%), Gaps = 40/387 (10%)
Query: 141 ELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED---ESKSLKSQIAEAKIICKT 197
ELE + L+K KE++ + Q D L A + K Q +E+ E +LK + IC++
Sbjct: 22 ELEGQ---LDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78
Query: 198 FKMSEER--RAIAIKDA-LN-ENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKV 253
+ ++++ + +K++ +N + QL + KQ+ + E E+ K SEL + + +
Sbjct: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQEL-KRCKSELERS----QQAAQ 133
Query: 254 HAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE------NGANL 307
A+ LN K T L + + ED + N E+E + E
Sbjct: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKA 193
Query: 308 DDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKT--------------KEELT 353
L A A+ S ++ LS + ++E+T
Sbjct: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
LQ + S + + S + L +LK + + +L +L E +
Sbjct: 254 PSRSTLQIGKRDANS-SFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAE 473
K ++ +L +A +L K+ +EL RT Y + Y + L T +
Sbjct: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKY--TALEQKLKKLTED 370
Query: 474 RNLSDLRKENAH--NKQKLTETELKFE 498
+ E+A +QK+ E E +F+
Sbjct: 371 LSCQRQNAESARCSLEQKIKEKEKEFQ 397
Score = 35.8 bits (81), Expect = 0.16
Identities = 89/445 (20%), Positives = 172/445 (38%), Gaps = 41/445 (9%)
Query: 82 LSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSE 141
L L E + LEK ++++ E + + E E+ + E + L+ ++ N +
Sbjct: 1552 LESLCEVYRQSLEK---LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQ 1608
Query: 142 LEDEI----LCLEKDLKEEKSKHSQQDELMADISK-SIQSLEDESKSLKSQIAEAKIICK 196
+ ++ L +E L EK K ++Q L ++++ +Q L+ S+SL E I
Sbjct: 1609 WQQKLTSVTLEMESKLAAEK-KQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAI--- 1664
Query: 197 TFKMSEERRAIAIKDALNENSQLQTSHK------QLFQQEAEVWKGQVSELNKQKITFED 250
K+ +E ++ H + QQ+ + +++E K T E
Sbjct: 1665 ---QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGEC 1721
Query: 251 S-----KVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEE---DTTDDDNLELEVNSQWE 302
S + E DK L A V + + D NL+L V
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781
Query: 303 NGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ 362
L ++ +K+ L +K L+ + + +QL + EL + + L+ +
Sbjct: 1782 ENLRLLHVIEDRDRKV---ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKE 1838
Query: 363 QASLQSENIYFESENQKLQQKLKIMTEFYQENEM---KLYRKLTVEENYRIEE--EEKLS 417
+ L + YF ++Q+L Q+++ + EM K R+ + ++ + +E+
Sbjct: 1839 NSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFL 1898
Query: 418 RVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLS 477
VE +LSR + + A LE +LE Q + + EK + E LS
Sbjct: 1899 DVENELSRIRSEKASIEHEALYLEADLE----VVQTEKLCLEKDNENKQKVIVCLEEELS 1954
Query: 478 DLRKENAHNKQKLTETELKFELLEK 502
+ E + +L K L++
Sbjct: 1955 VVTSERNQLRGELDTMSKKTTALDQ 1979
Score = 35.4 bits (80), Expect = 0.20
Identities = 32/144 (22%), Positives = 68/144 (47%), Gaps = 21/144 (14%)
Query: 314 ALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYF 373
AL+K+ +L L L+ E+ QL ++ ++ + ++N +T+ +L+ EN
Sbjct: 16 ALQKI---QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN--- 69
Query: 374 ESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETY 433
Q+L + E ++ + K+ +L V+E+ +++ E +L+ +Q+E
Sbjct: 70 --------QRLMEICESLEKTKQKISHELQVKES-------QVNFQEGQLNSGKKQIEKL 114
Query: 434 RKLAKDLEEELERTVHFYQKQVIS 457
+ K + ELER+ Q +S
Sbjct: 115 EQELKRCKSELERSQQAAQSADVS 138
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 79.3 bits (194), Expect = 1e-14
Identities = 119/502 (23%), Positives = 200/502 (39%), Gaps = 83/502 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAA----EEARSLE 129
+ ++L + GL E +L + K+ + ++ES L+D E EE +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQ--QLESELQDLEMENQTLQKNLEELKISS 807
Query: 130 ATCEKLNRSNSELEDEILCLEKDLK--EEKSKHSQQ-----DELMADISKSIQSLEDESK 182
E+L + N LE E LEKD K E+++K +Q D + + + I +LE E+K
Sbjct: 808 KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Query: 183 SLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELN 242
+L +I K C K E+ +K A + L T + L +E K Q +
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV---SEKLKTQQMNND 924
Query: 243 KQKITFEDSKV--------HAEQVLNDKENHI------KTLTGHLPMMKDQAAV----LE 284
+K+T E K+ H EQ +D + TL L + +++ A LE
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984
Query: 285 EDTTDDDNLELEVNSQWENGANL------------DDPLKGALKKLIHAAK------LNV 326
E T + L E+ + +N L P+ G K ++ L V
Sbjct: 985 ESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKV 1044
Query: 327 SLKSLEGERNHIII---------QLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESEN 377
+ +E ERN+ + QL +++ L I LQ Q SLQ +N +++N
Sbjct: 1045 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1104
Query: 378 QKLQQKLKIM----TEFYQENEMKLYRKLTVEENYR--IEEEEKLSRVEEKLSRATEQLE 431
KLQ + + T +N L ++ ++E I+E E L + + L + E+LE
Sbjct: 1105 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1164
Query: 432 TYRKLAKDLEEELERTVHFYQKQVISYE--KRGHDNWLAARTAERNLSDLRKENAHNKQK 489
ER Y+ + + K H N R+L D + K +
Sbjct: 1165 LLH----------ERQASEYESLISKHGTLKSAHKN---LEVEHRDLEDRYNQLLKQKGQ 1211
Query: 490 LTETELKFELLEKDPNALDVSN 511
L + E K +E++ L+ N
Sbjct: 1212 LEDLE-KMLKVEQEKMLLENKN 1232
Score = 78.6 bits (192), Expect = 2e-14
Identities = 100/441 (22%), Positives = 189/441 (42%), Gaps = 31/441 (7%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSL-IQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEK 134
+K TL E + K+LE+ + + + S + + K +E + L + ++
Sbjct: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598
Query: 135 LNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKII 194
+ S++E E ++K+L+ K K + +EL + LE E++ L+ +I KI
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEEL----ENELHHLEKENELLQKKITNLKIT 654
Query: 195 CKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEA-EVWKGQVSELNKQKITFEDSKV 253
C+ + E+ + ++ L + FQ E+ E Q+ E N + +S
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Query: 254 HAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKG 313
A + + K L +K +L+ + LE+ L L+
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 314 ALKKLIHAAKLNVSLKSLEGERNHIIIQLSEV---DKTKEELTEHIKNLQTQQASLQSEN 370
+ KK+ +L L+ LE E + L E+ K E+L + K+L+ + + L+ +
Sbjct: 775 SNKKI---QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 371 IYFESENQKLQQKLKIMTEFYQENEMK----------LYRKLTV--EENYRIEEEEKLSR 418
E EN++L+Q+ +I +EN +K L +++ + E R++E EK ++
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 419 VEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSD 478
E + RAT ++T L +DL E +T Q+ EK H+ ER L D
Sbjct: 892 --ELVKRATIDIKTLVTLREDLVSEKLKT----QQMNNDLEKLTHELEKIGLNKERLLHD 945
Query: 479 LRKENAHNKQKLTETELKFEL 499
+ ++ KL E++L+ L
Sbjct: 946 -EQSTDDSRYKLLESKLESTL 965
Score = 75.1 bits (183), Expect = 2e-13
Identities = 91/410 (22%), Positives = 176/410 (42%), Gaps = 34/410 (8%)
Query: 124 EARSLEATCEKLNRSNSELE---DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
E +SL T E+L + +E +IL +EK+ + K + + +S+Q+ ++
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
SK L + A+ + +T + + ER+ ++ +Q +S +Q Q AE + +
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 241 LNK-------------QKITFEDSKVHAE-QVLNDKENHIKTLTGHLPMMKDQAAVLEED 286
NK KI FE ++ E + +K + L L ++ + +L++
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 287 TTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVD 346
T+ ++ + + + L+ + K L L L+SLE E + QL E +
Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEEN 703
Query: 347 KTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEM--KLYRKLTV 404
E +K + A LQ EN ESE ++L++ L+++ +++ E Y+ L +
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 405 EENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHD 464
EN R+ ++ L +K+ + +L+ + L++ LE + K++ EK
Sbjct: 764 -ENQRL--QKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSKRLEQLEKENKS 819
Query: 465 NWLAARTAERNLSDLRKENAHNKQK-------LTETELKFELLEKDPNAL 507
E++ L KEN +Q+ L E +K LEK+ L
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Score = 60.5 bits (145), Expect = 6e-09
Identities = 81/388 (20%), Positives = 175/388 (45%), Gaps = 41/388 (10%)
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
K S L E+ + ++ + + ++ E + D + ++ +E E K L+ +
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 194 ICKTFKM-SEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSK 252
++ +M +E A+ K + + + S + + E +K +V EL + ++K
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 253 VHAEQVLN------------DKEN-HIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNS 299
E L +KEN +K + M +D E+ ++ N+ LE+
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE-NMTLEMAQ 419
Query: 300 QWENGANLDDPLKGALKKLIHAAKLNVS-LKSLEGERNHIII-QLSEVDKTKEELTEHIK 357
+ +L L L+++ ++L+ + KSL E N + +L +++ + LT+ ++
Sbjct: 420 KQSMDESLH--LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 358 NLQTQQASLQ---SENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEE 414
L+T S++ S+ + E ENQ+L +K++I+ ENE+ V+E ++ +
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEIL-----ENEI-------VQEKQSLQNCQ 525
Query: 415 KLSR-VEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAE 473
LS+ + ++ ++ + +ET R+ ++ + LE+ + V S +R + +AE
Sbjct: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR------SQISAE 579
Query: 474 RNLSDLRKENAHNKQKLTETELKFELLE 501
+ D+ KEN + + ET K +E
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIE 607
Score = 57.0 bits (136), Expect = 7e-08
Identities = 105/513 (20%), Positives = 213/513 (41%), Gaps = 74/513 (14%)
Query: 74 REQKLGATLSGLIEEKC----KLLEKFSLIQKEYEGYE--------VESSL----EDASF 117
+E+K+ A L +EE +L ++ ++K YE + V+SS ED +
Sbjct: 972 KEEKIAA-LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW 1030
Query: 118 EKAAAEEARSLEATCEKL---NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSI 174
E+ + E R L ++L R+N+ L+ E L+ LK+ +++++ + + +
Sbjct: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
Query: 175 QSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV- 233
SL++++ +L++Q A+ ++ T L + S L+ ++ + ++ ++
Sbjct: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1150
Query: 234 --WKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD 291
+ + + K ++ E E +++ G L V D D
Sbjct: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKH--------GTLKSAHKNLEVEHRDLEDRY 1202
Query: 292 NLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSL----KSLEGERNHIIIQLSEVDK 347
N L+ Q E+ L+ LK +K++ K + ++ K L GE + + S++ K
Sbjct: 1203 NQLLKQKGQLED---LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259
Query: 348 TKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIM--TEFYQENEMKLYRKL--- 402
E L KNL++ + + E E+E KL+++ + + T N+ +L +L
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1319
Query: 403 TVEENYRI------------------EEEEKLSRVEEKLSRATEQLETYRKLAKDLEEEL 444
EEN + E + L VE++ + ++L R+ + LEE++
Sbjct: 1320 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR--QYIDKLNELRRQKEKLEEKI 1377
Query: 445 ERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKE-NAHNKQKLTETELKFELLE-- 501
FY R NW+ + R L +K+ N ++ LT T + + E
Sbjct: 1378 MDQYKFYDPS----PPRRRGNWITLKM--RKLIKSKKDINRERQKSLTLTPTRSDSSEGF 1431
Query: 502 -KDPNALDVSNTAFGREHAPNGPAPLGQRSSET 533
+ P+ +++ G +G LG + S T
Sbjct: 1432 LQLPHQDSQDSSSVGSNSLEDGQT-LGTKKSST 1463
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 77.0 bits (188), Expect = 6e-14
Identities = 105/473 (22%), Positives = 208/473 (43%), Gaps = 79/473 (16%)
Query: 76 QKLGATLSGLIEEK----CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEAT 131
++L + L++EK C++ E +QK + + D + E E
Sbjct: 1357 EELHHNIDDLLQEKKSLECEVEELHRTVQKRQQ----QKDFIDGNVESLMTE------LE 1406
Query: 132 CEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEA 191
EK + + ++ DEI C+EK L + +S+ + D L+A+ + ++++K+ + +A
Sbjct: 1407 IEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 1466
Query: 192 K-IICKTFKMSEERRAIAIKDALN------ENSQLQTSHKQLFQ---QEAEVWKG----- 236
K + +T +EE A + A+N + LQ K L Q ++ E+ K
Sbjct: 1467 KRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIV 1526
Query: 237 -------QVSELNKQKITFEDSKVHAE-QVLNDKENHIKTLTGHLPMMKDQAAVLEEDTT 288
Q K+K+T E K+ + ++ E+H HL ++K+ +L+
Sbjct: 1527 AAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDH------HLQVLKESEVLLQAKRA 1580
Query: 289 DDDNLELEVNSQWENGANLDDPLKGALKKLIH---------AAKLNVSLKSLEGERNHII 339
+ + L+ +V SQ + A LD L G K+ +H A L +L+ E E
Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQL-GHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC 1639
Query: 340 IQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKL- 398
+ EV EEL+ L Q + +++ + E +K ++ L+++ +++ +L
Sbjct: 1640 NHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
Query: 399 ------------YRKLTVEENYRIEEEEK--LSRVEEKLSRATEQLETYRKLAKDLEEEL 444
+ L ++ + R+ E EK ++ +EEKL +LE +++++ + E+
Sbjct: 1700 NILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL-----ELENLQQISQQQKGEI 1754
Query: 445 ERTVHFYQKQVISYEKRGHDNWLA-ARTAERNLSDLRKENAHNKQKLTETELK 496
E +QKQ++ +KR + A +R + + L KE ++K E K
Sbjct: 1755 E-----WQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK 1802
Score = 69.3 bits (168), Expect = 1e-11
Identities = 67/385 (17%), Positives = 176/385 (45%), Gaps = 26/385 (6%)
Query: 86 IEEKCKLLEK-FSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELED 144
++EKC + EK + ++ E S +E ++ EK R L+ ++LNR L +
Sbjct: 1792 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELN-VRKLQQELDQLNRDKLSLHN 1850
Query: 145 EILCLEKDLKEEKSKHSQQDELMADI--------------SKSIQSLEDESKSLKSQIAE 190
+I +++ L+E++ + E +A++ +K L E L+ I+E
Sbjct: 1851 DISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISE 1910
Query: 191 AKII---CKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKIT 247
C+ + +++++ +++ + EN + +FQ+ + + + S+L K+T
Sbjct: 1911 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1970
Query: 248 FEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANL 307
++ + E+ L D+++ + + + +++ L+E+ ++LE ++ +
Sbjct: 1971 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 2030
Query: 308 DDPLKGALKKLIHAAKLNVSLKS-LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASL 366
+ L +L+ K S+++ RN + + + +K L E +K Q++ L
Sbjct: 2031 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALK---IQRSQL 2087
Query: 367 QSENIYFESENQKLQQK---LKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKL 423
+ + + EN +Q++ ++++ + E +L ++L + E +++++ ++
Sbjct: 2088 EKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLE 2147
Query: 424 SRATEQLETYRKLAKDLEEELERTV 448
R E + R L ++++E+ ++
Sbjct: 2148 RRQMEISDAMRTLKSEVKDEIRTSL 2172
Score = 64.3 bits (155), Expect = 4e-10
Identities = 105/451 (23%), Positives = 194/451 (43%), Gaps = 62/451 (13%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEA--RSLEATCEKLNRSNSEL 142
L ++K KL E+ +QK+ E E ED + E ++ A EKL +
Sbjct: 1536 LSKKKEKLTEELQKLQKDIEMAERN---EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQ 1592
Query: 143 EDEILCLEKDLKEEKSK-HSQQDELM---ADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
+ E+ L++ L +K + H Q ++ AD+ ++++ E E + I E K + +
Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEEL 1652
Query: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDS----KVH 254
+ + I + +QL T KQ ++E E + + +++K K ++ ++
Sbjct: 1653 SFQKGELNVQISE---RKTQL-TLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLE 1708
Query: 255 AEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGA 314
++ K H + ++ + K Q AVLEE LELE N + KG
Sbjct: 1709 NHELQGLKLQHDQRVS---ELEKTQVAVLEE------KLELE------NLQQISQQQKGE 1753
Query: 315 L---KKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHI-----KNLQTQQA-S 365
+ K+L+ K + + E ++ + K KE+L E K QT++ +
Sbjct: 1754 IEWQKQLLERDKREIERMTAESRALQSCVEC--LSKEKEDLQEKCDIWEKKLAQTKRVLA 1811
Query: 366 LQSENIYFESEN-QKLQQKL-KIMTEFYQEN--EMKLYRKLTVEENYRIEEEEKLSRVEE 421
EN E N +KL+ + K+ E Q N ++ L+ ++ + E+ E ++ ++E
Sbjct: 1812 AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQE 1871
Query: 422 KLSRATEQLETYRKLAKDLEEELERTVHF---------YQKQVISYEKRGHDNWLAARTA 472
+L+ + L LAK ++ L T H QK + + R D T
Sbjct: 1872 ELANVQDHLN----LAK--QDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETK 1925
Query: 473 ERNLSDLRKENAHNKQKLTETELKFELLEKD 503
++ L L+ E NK KL + E+ F+ L+K+
Sbjct: 1926 QQQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
Score = 59.7 bits (143), Expect = 1e-08
Identities = 92/473 (19%), Positives = 197/473 (41%), Gaps = 70/473 (14%)
Query: 75 EQKLGATLSGLIEEKCKL---LEKFSLIQKEYEGYEVESSLEDASFEK---AAAEEARSL 128
E+ L L + + K +L L+ L E +G +++ + EK A EE L
Sbjct: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1740
Query: 129 EATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI 188
E + + E+E + LE+D +E E M S+++QS + K +
Sbjct: 1741 ENLQQISQQQKGEIEWQKQLLERDKREI--------ERMTAESRALQSCVECLSKEKEDL 1792
Query: 189 AEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITF 248
E I + K+++ +R +A A ENS+++ S+ + + + ++ +LN+ K++
Sbjct: 1793 QEKCDIWEK-KLAQTKRVLA---AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSL 1848
Query: 249 EDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEED---TTDDDNLELEVN------- 298
+ +Q L +K + +L L ++D + ++D TT ++ L
Sbjct: 1849 HNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDI 1908
Query: 299 SQWENGAN---------------LDDPLKGALKKLIHA---------------AKLNVSL 328
S+W N L + ++ KL+ +KL S
Sbjct: 1909 SEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
Query: 329 KSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMT 388
+L+ +++ + +L++ +++ + + + +LQ E + ES + L Q + ++
Sbjct: 1969 VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLS 2028
Query: 389 EFYQENEMKLYRKLTVEEN----------YRIEEEEKLSRVEEKLSRATEQLETYR-KLA 437
E Q+ K L +++ R + + + E++++ E L+ R +L
Sbjct: 2029 EREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLE 2088
Query: 438 KDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKL 490
K+L E+ + QK++ + E DN AR + L+ ++ E K+++
Sbjct: 2089 KNLLEQKQEN-SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQM 2140
Score = 50.1 bits (118), Expect = 8e-06
Identities = 73/337 (21%), Positives = 138/337 (40%), Gaps = 57/337 (16%)
Query: 123 EEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESK 182
+EA LE EK + + + EI L+ + SK + + A S Q L+ +K
Sbjct: 510 QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK 569
Query: 183 S---LKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVS 239
L+S++ E I+ + K +EE IKD + ++ Q + + +++ E G +S
Sbjct: 570 QYQQLESRLDE--ILSRIAKETEE-----IKDLEEQLTEGQIAANEALKKDLE---GVIS 619
Query: 240 ELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNS 299
L + T + A+ + +TL L ++ + LE D +N+ E+
Sbjct: 620 GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL-- 677
Query: 300 QWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQL--------SEVDKTKEE 351
A L+ L+ ++N SL+ +G+ + +L +E ++ KEE
Sbjct: 678 -----AELESALQ-------EQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE 725
Query: 352 LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIE 411
L + + Q +Q++LQ+E E E Q L+ L + + E
Sbjct: 726 LEKVTRLTQLEQSALQAE---LEKERQALKNALG-------------------KAQFSEE 763
Query: 412 EEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTV 448
+E++ S + KL + ++ KD + L V
Sbjct: 764 KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVV 800
Score = 48.9 bits (115), Expect = 2e-05
Identities = 93/426 (21%), Positives = 178/426 (41%), Gaps = 66/426 (15%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESS------LEDASFEKAAAEEAR---SLEATCEKL 135
L +EK LL++ + +++E + E+ + E A E A E+ SL+ T L
Sbjct: 642 LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDL 701
Query: 136 NRSNSELEDEILCLEKD---LKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAK 192
+ +ELE + + + LKEE K ++ +L ++ LE E ++LK+ + +A+
Sbjct: 702 SAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQA--ELEKERQALKNALGKAQ 759
Query: 193 IICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG---------QVSELNK 243
+ + + E A +K ++N+ L+ K V G +V EL +
Sbjct: 760 FSEEKEQENSELHA-KLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRR 818
Query: 244 Q-KITFEDSKVHAE-----QVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELE- 296
+ K+ + +H+ + L D + + +D+A V E ++ L+ E
Sbjct: 819 KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK 878
Query: 297 -VNSQWENGANLDDPLKGALK--KLIHAAK----------LNVSLKSLEGERNHIIIQLS 343
Q E + L+ + K H A+ L +LKS+E + +QL
Sbjct: 879 LATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQ 938
Query: 344 EVDKTKEELTEHIKNLQ----TQQASLQSENIYFESENQKLQQ------KLKIMTEFYQE 393
E D+ KE + ++ L+ + A Q + + E +KL++ KL +
Sbjct: 939 EADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAK 998
Query: 394 NEMK----LYRKLTVEENYRIEEEEKLSR----VEEKLSRATEQLETYRKLAKDLEE--- 442
+++K K+ E ++E E+ SR L+RA ++E + L + E
Sbjct: 999 DQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFR 1058
Query: 443 -ELERT 447
E+E+T
Sbjct: 1059 LEMEKT 1064
Score = 43.1 bits (100), Expect = 0.001
Identities = 90/416 (21%), Positives = 169/416 (40%), Gaps = 79/416 (18%)
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
+E+ LE+DL+++ + + + I++ + +KSLK + K C+ K
Sbjct: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLN 329
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEA-----------EVWKGQVSELNKQ-------- 244
+ +K E ++ +L Q+ A + + +E++K
Sbjct: 330 TKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389
Query: 245 KITFEDSKVHAEQVLNDK---------------ENHIKTLTGHLPM--------MKDQAA 281
K ++ + E + D N L GH P+ K AA
Sbjct: 390 KSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAA 449
Query: 282 V--LEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGE----- 334
L E + + E ++ E L++ ++ LKK+ A K ++ K L G
Sbjct: 450 QTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGK-DLLYKQLSGRLQLVN 506
Query: 335 --RNHIIIQLSEVDKTKEELT---EHIKNLQTQQASLQS---ENIYFESENQKLQQKLKI 386
R + +++K K+E+ + IK+LQ SL S ++ + +++ +Q+L I
Sbjct: 507 KLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDI 566
Query: 387 MTEFYQENEMKLYRKLTVEENYRI-EEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELE 445
M + YQ+ E +L L+ RI +E E++ +EE+L+ Q+ L KD LE
Sbjct: 567 MNKQYQQLESRLDEILS-----RIAKETEEIKDLEEQLTEG--QIAANEALKKD----LE 615
Query: 446 RTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLE 501
+ Q+ + + + + A A+ LR E Q+LTE E + + LE
Sbjct: 616 GVISGLQEYLGTIKGQ-------ATQAQNECRKLRDEKETLLQRLTEVEQERDQLE 664
Score = 38.5 bits (88), Expect = 0.024
Identities = 74/355 (20%), Positives = 140/355 (39%), Gaps = 71/355 (20%)
Query: 142 LEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMS 201
LE+E+ LE ++ KSK ++ + A +S + +E+ ++ + E K + ++
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL--ECEVE 1378
Query: 202 EERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLND 261
E R + Q QQ+ + G V L ++ E S H E ++++
Sbjct: 1379 ELHRTV-----------------QKRQQQKDFIDGNVESL-MTELEIEKSLKHHEDIVDE 1420
Query: 262 KENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHA 321
E KTL +++ +L E E E++ E N + A + L+
Sbjct: 1421 IECIEKTLLKRRSELREADRLLAE-------AESELSCTKEKTKNAVEKFTDAKRSLLQT 1473
Query: 322 AKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQ 381
+ LE + L + D+ L K+L+ Q
Sbjct: 1474 ES---DAEELERRAQETAVNLVKADQQLRSLQADAKDLE--------------------Q 1510
Query: 382 QKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLE 441
K+K QE +K K+ ++ + + LS+ +EKL TE+L+ KL KD+E
Sbjct: 1511 HKIK------QEEILKEINKIVAAKD---SDFQCLSKKKEKL---TEELQ---KLQKDIE 1555
Query: 442 EELERTVHFYQ----KQVISYEKRGHDNWLAAR--TAERNLSDLRKENAHNKQKL 490
H Q +V+ KR L ++ + ++ ++ L ++ H K++L
Sbjct: 1556 MAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
Score = 37.7 bits (86), Expect = 0.041
Identities = 39/183 (21%), Positives = 76/183 (41%), Gaps = 10/183 (5%)
Query: 328 LKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIM 387
LKS + E + + +K EEL +I +L ++ SL+ E QK QQ+
Sbjct: 1335 LKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQ---- 1390
Query: 388 TEFYQENEMKLYRKLTVEENYRIEEE--EKLSRVEEKLSRATEQLETYRKLAKDLEEELE 445
+F N L +L +E++ + E+ +++ +E+ L + +L +L + E EL
Sbjct: 1391 KDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELS 1450
Query: 446 RTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPN 505
T + V + D + E + +L + L + + + L+ D
Sbjct: 1451 CTKEKTKNAVEKFT----DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAK 1506
Query: 506 ALD 508
L+
Sbjct: 1507 DLE 1509
Score = 30.0 bits (66), Expect = 8.6
Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 25/201 (12%)
Query: 315 LKKLIHAAKLNVS---LKSLEGERNHIIIQL-----SEVDKTKEELTEHIKNLQTQQASL 366
L KL+ +LN+S + +EG N +Q +E++ L + +K+L+ +L
Sbjct: 143 LDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRV--LNL 200
Query: 367 QSENIYFESENQKLQQKLKIMTEFYQENEMKL---YRKLTVEENYRIEEEEKLSRVEEKL 423
+ I + KL+ +++ EN + Y + T+ +E E +
Sbjct: 201 KGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDR 260
Query: 424 SRATEQ--LETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDN----------WLAART 471
A E+ LE +L +DLE+++ T KQ E+ + + L ++
Sbjct: 261 QEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQS 320
Query: 472 AERNLSDLRKENAHNKQKLTE 492
E SDL +N KQK E
Sbjct: 321 CEELKSDLNTKNELLKQKTIE 341
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 76.6 bits (187), Expect = 8e-14
Identities = 101/449 (22%), Positives = 191/449 (42%), Gaps = 47/449 (10%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEI 146
++K + LE +L+QK E + + + K A E + A +L N L++++
Sbjct: 522 DQKIQNLE--ALLQKSKENISLLEKEREDLYAKIQAGEGET--AVLNQLQEKNHTLQEQV 577
Query: 147 LCLEKDLKEEKSKHSQQDELMADISKS----IQSLEDESKSLKSQIAEAKIICKTFKMSE 202
L + LK + H Q E + D + +++ +D SL++ + E K
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 203 ERRAIAIK---DALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQ--KITFEDSKVHAEQ 257
+ I IK + L +T+ + Q + + + + ++ KIT + +V A+
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK- 696
Query: 258 VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKK 317
L DK+ H L HL K++ LE+ T + LE ++ + + + AL+
Sbjct: 697 -LQDKQEHCSQLESHLKEYKEKYLSLEQKT---EELEGQIKKLEADSLEVKASKEQALQD 752
Query: 318 LIHAAKLNVSL--------KSLEGERNHIIIQLSEVD-KTKEELTEHIKNLQTQQASLQS 368
L +LN L K LE E+ I+ + +D + K E E IK T+Q +
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKE--IVSSTRLDLQKKSEALESIKQKLTKQ---EE 807
Query: 369 ENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE---EKLSRVEEKLSR 425
E + + + L Q+ KI ++E ++ +T + ++E+E +LS V++KLS+
Sbjct: 808 EKQILKQDFETLSQETKIQ---HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 864
Query: 426 ATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKE--N 483
++ L K+ + E E+ + ++ EK + + N +KE
Sbjct: 865 VSDSL-------KNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 484 AHNKQKLTETELKFELLEKDPNALDVSNT 512
+ K+K +LK EL + NT
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Score = 73.9 bits (180), Expect = 5e-13
Identities = 96/457 (21%), Positives = 189/457 (41%), Gaps = 58/457 (12%)
Query: 87 EEKCKLLEKFSLIQKEY---EGYEVESSLEDASFEKAAAE---EARSLEATCEKLNRSNS 140
EE K LEK+ +Q++ +G +SS E S E+ E E +++ + + +
Sbjct: 107 EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAA 166
Query: 141 ELEDEILCLEKDLKEEKSKHSQQDELMADISKS-------IQSLEDESKS---------L 184
+L EI ++ EE+S ++ + +++ IQ L+ E L
Sbjct: 167 QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
Query: 185 KSQIAEAKIICKTFKMSEERRAIAIKDALNE-NSQLQTSHKQLFQQEAEVWKGQ------ 237
K ++ + + + + ER + +KD + SQ +S + Q +E+ KG
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 238 VSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD----NL 293
V EL K K + +N+ +TLT +L + LEE ++ N+
Sbjct: 287 VQELQKLKSS-----------VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI 335
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELT 353
+ ++ + + L L + L +++V L + +LSEV+ + L
Sbjct: 336 QATLHQKDLDCQQLQSRLSASETSL---HRIHVELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
K LQ Q+ + + +SE +L KL E +L + + +++E
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE 452
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAE 473
++++ ++ KLSR EQL+ + +L+ +L++T +Q+Q + R A+
Sbjct: 453 QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ----QALQQSTTAKLREAQ 508
Query: 474 RNLSDLRKENAHNKQKLTETEL-------KFELLEKD 503
+L + ++ QK+ E LLEK+
Sbjct: 509 NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Score = 68.2 bits (165), Expect = 3e-11
Identities = 100/427 (23%), Positives = 195/427 (45%), Gaps = 48/427 (11%)
Query: 94 EKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDL 153
EK+ ++++ E E + +A + A + ++L+ ++ + N++LE L K L
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ-DLQQQRQLNTDLELRATELSKQL 774
Query: 154 KEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDAL 213
+ EK S D+ K ++LE + L Q E +I+ + F+ + I ++ L
Sbjct: 775 EMEKEIVSST---RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE-L 830
Query: 214 NENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHL 273
N Q + Q + E E ++S + + DS +++ +KEN
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF-EKENQ-------- 881
Query: 274 PMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAA-KLNVSLKSLE 332
K +AA+L+ + T + L+ ++ Q EN LK +L+K A+ +L + L S++
Sbjct: 882 ---KGKAAILDLEKTCKE-LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 333 GERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQ 392
+ L + +K +++L +I L+ Q+S Q + + + LQ +LKI
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELK--QSSEQKKK-----QIEALQGELKIAVLQKT 990
Query: 393 ENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDL---EEEL----- 444
E E KL ++LT E+EK+S ++ ++ ET+++L D E EL
Sbjct: 991 ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ---ETFKQLQSDFYGRESELLATRQ 1047
Query: 445 -----ERTVHFYQKQVISYEKR-GHDNWL--AARTAERNLSDLRKENAHNKQKLTETELK 496
E + Q+ +IS + G+ N L +TA+ + L +++A +Q+L E
Sbjct: 1048 DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAK---ATLEQDSAKKEQQLQERCKA 1104
Query: 497 FELLEKD 503
+ ++K+
Sbjct: 1105 LQDIQKE 1111
Score = 65.9 bits (159), Expect = 1e-10
Identities = 97/485 (20%), Positives = 206/485 (42%), Gaps = 82/485 (16%)
Query: 70 LYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLE 129
+YV QKL ++++ L ++ L E +L++KE + ++E + S K ++++
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTE--NLLKKEQDYTKLEEKHNEESVSK------KNIQ 336
Query: 130 ATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIA 189
AT + + +L+ + E L + S++ E + + + +E + + LK++
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE-- 394
Query: 190 EAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWK--GQVSE---LNKQ 244
FK +++R + L S++ H +L + E ++ + G++ E L+ +
Sbjct: 395 --------FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE 446
Query: 245 KITFEDSKV--------HAEQVLNDKENHIKTLTGHLPMMK----DQAAVLEEDTTDDDN 292
K+ ++ +V E+ L +K + L L K +Q A+ + T
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Query: 293 LELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGE-----------RNHIIIQ 341
+ ++ + D ++ L+ L+ +K N+SL E E ++ Q
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQN-LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 342 LSEVDKTKEE----LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMK 397
L E + T +E LTE +KN Q++ EN++ + + QK + Q+ +
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKN-QSESHKQAQENLHDQVQEQKAHLRAA------QDRVLS 618
Query: 398 LYRKLTVEENYRIEEEEKLSRVEEKLSRATE------------------QLETYRKLAKD 439
L + + E +EK+S+++ ++ TE L+T + +D
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 440 LEEELER-TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFE 498
++EL + T Q +K+ H + L E +L + +++ +QK E E + +
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQL-----ESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 499 LLEKD 503
LE D
Sbjct: 734 KLEAD 738
Score = 65.5 bits (158), Expect = 2e-10
Identities = 82/340 (24%), Positives = 159/340 (46%), Gaps = 44/340 (12%)
Query: 62 SFRSVRSRLYVGREQKLGATLSGL--IEEKCKLLEKFSLIQKEYEGYE----VESSLEDA 115
+F+ ++S Y GRE +L AT L +EEK L ++ + + G + E A
Sbjct: 1027 TFKQLQSDFY-GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085
Query: 116 SFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQ 175
+ E+ +A++ + L+ C+ L +++ E EK+L EKSK ++ +E+ K I
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQ----DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT 1141
Query: 176 SLEDESKSLK-------SQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQ 228
L +E KS K + + +AK + K+ + +A ++K A+ + + Q K +
Sbjct: 1142 KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
Query: 229 QEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTT 288
+E E EL K+ I +++K+H+E + +KE G +++A + + T
Sbjct: 1202 KEEE-------ELKKEFIE-KEAKLHSE--IKEKE------VGMKKHEENEAKLTMQITA 1245
Query: 289 DDDNLELEVNSQWENGANLDDPLKGALKKLI-HAAKLNVSLKSLEGERNHIIIQL----S 343
++NL V +W++ L+ L A L ++++ + ER ++ +
Sbjct: 1246 LNENLG-TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG 1304
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
E++K + ++ E + L A++Q ENQ LQ K
Sbjct: 1305 EIEKLQTKVLELQRKLDNTTAAVQE----LGRENQSLQIK 1340
Score = 60.8 bits (146), Expect = 5e-09
Identities = 82/439 (18%), Positives = 185/439 (42%), Gaps = 28/439 (6%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKL 135
Q+ TL + + + L+ S K+ + + E + +AA + SLE + +L
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
Query: 136 NRSNSELEDEILCLEKDLK--------EEKSKHSQQDELMADISKSIQSLEDESKSLKSQ 187
N +E ++++ L+ +K E +K +Q+ +L + + +L+D+ + L
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
Query: 188 IAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKIT 247
+ + + +E ++ L E + S +Q+ E +GQ+ +L +
Sbjct: 687 TTQLDQVTAKLQDKQE-HCSQLESHLKEYKEKYLS----LEQKTEELEGQIKKLEADSLE 741
Query: 248 FEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANL 307
+ SK A Q L + L + Q +E++ L+L+ S
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLE-MEKEIVSSTRLDLQKKS-------- 792
Query: 308 DDPLKGALKKLIHAAKLNVSLK-SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASL 366
+ L+ +KL + LK E IQ E++ + ++ ++ ++ +L
Sbjct: 793 -EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851
Query: 367 QSENIYFESENQKLQQKLK-IMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSR 425
+E + + K+ LK +EF +EN+ L +E+ + + + ++E L
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 426 ATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAH 485
E ++ K K+ +L+ ++ Q+Q+I + N + + N+++L++ +
Sbjct: 912 QKELKKSLEK-EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
Query: 486 NKQKL--TETELKFELLEK 502
K+++ + ELK +L+K
Sbjct: 971 KKKQIEALQGELKIAVLQK 989
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/475 (20%), Positives = 197/475 (41%), Gaps = 66/475 (13%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARS-LEATCE 133
E K A L+ L ++ +L+ + + E L+ +K AE+A + L+ +
Sbjct: 441 ESKQSAELNKLRQDYARLVNELT---------EKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
+ R E++ I + + ++ + D+ + E+E +SL S++ + +
Sbjct: 492 EAERRWEEVQSYI----------RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 194 ICKTFKMSEERRAIAIKDA----LNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFE 249
K E+R + + ++ +N+ LQ + + +Q E K Q+ + + Q
Sbjct: 542 S----KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN-EALKAQIQQFHSQIAAQT 596
Query: 250 DSKVHAEQ---VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
+ V AE+ V+ +K+ IK L +D+ EE+ D N+
Sbjct: 597 SASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL---------- 646
Query: 307 LDDPLKGALKKLIHAAKLNVSLK-SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQAS 365
LK ++KL A + LE + + ++ ++ +E+L I N +
Sbjct: 647 ----LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI 702
Query: 366 LQSENIYFESENQKLQ---------QKLKIMTEFYQENEMKLYRKLTVEENYRIE---EE 413
L +N +SE QKLQ ++ M + QE + KL + E I+ +E
Sbjct: 703 LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKD------LEEELERTVHFYQKQVISYEKRGHDNWL 467
E+L+ + + S T++++ + D L EEL++ +H ++ S E+ L
Sbjct: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
Query: 468 AARTAERNLSDLRKENAHNKQKLTETEL-KFELLEKDPNALDVSNTAFGREHAPN 521
E+ + DL++E K+++ +L K + L ++ N G+E N
Sbjct: 823 KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMN 877
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/383 (20%), Positives = 168/383 (43%), Gaps = 38/383 (9%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEK--AAAEEARSLEAT 131
+++++ T L E+ +L K ++E + + + L A +K A A E +
Sbjct: 612 KDKQIKQTEDSLASERDRLTSK----EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
Query: 132 CEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEA 191
EK+ +S +D+I LE+ L+ E S ++ +++ D +K+++S + ++L S+
Sbjct: 668 LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Query: 192 KIICKTFKMSEER-RAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQ------ 244
++ + K +E+ + + L E +Q + K ++E + + S L K+
Sbjct: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATK---EEELNAIRTENSSLTKEVQDLKA 784
Query: 245 ----KITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
+++F ++V+++K+ IK++ L + A E+ D L+ E+ +
Sbjct: 785 KQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQD---LKQEIKAL 841
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
E N+ L +L LK E + N + L E +K + +++LQ
Sbjct: 842 KEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 901
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
+ SL++ + Q LK + Q E+++ K E+E +L R+E
Sbjct: 902 EENESLKAH------VQEVAQHNLKEASSASQFEELEIVLK---------EKENELKRLE 946
Query: 421 EKLSRATEQLETYRKLAKDLEEE 443
L L + +L +D+++E
Sbjct: 947 AMLKERESDLSSKTQLLQDVQDE 969
Score = 60.1 bits (144), Expect = 8e-09
Identities = 89/392 (22%), Positives = 174/392 (44%), Gaps = 50/392 (12%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEAT--C 132
+Q+L L L+E + K + K +Q + + ++ A ++ ++ A A+
Sbjct: 543 KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 602
Query: 133 EKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAK 192
E+L++ +E + +I E L E+ + + ++E + DI L+ E + L++ E
Sbjct: 603 EELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQA 662
Query: 193 IICKTFKMSEERRAIAIKD----ALNENSQLQTSHK----QLFQQEAEVWKGQVSELNK- 243
++ + ++++ +KD L E Q + S+K ++ + + K +V +L
Sbjct: 663 --AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 244 -QKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT----TDDDNLELEVN 298
+ +D E+ + +K+ +KT+ L Q A EE+ T++ +L EV
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 299 S--QWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHI 356
+N L LKK+IH + + +KS+E +++++ +KT ++L + I
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIH--EKDGKIKSVEELLEAELLKVANKEKTVQDLKQEI 838
Query: 357 KNLQTQQASLQSEN---IYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
K L+ + ++Q E + S+ Q+LQ LK E Q N MK +EE+
Sbjct: 839 KALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEE--QMNTMKAV----------LEEK 886
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEEELE 445
EK L K +DL+EE E
Sbjct: 887 EK-------------DLANTGKWLQDLQEENE 905
Score = 57.4 bits (137), Expect = 5e-08
Identities = 84/367 (22%), Positives = 146/367 (39%), Gaps = 46/367 (12%)
Query: 143 EDEILCLEKDLKEEKS--KHSQQDELMADISKSIQSLEDESKSL---KSQIAEAKIICKT 197
EDE LC+ LKE+ + + + +++ I L+++ K L K A K CK
Sbjct: 298 EDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357
Query: 198 FK---MSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVH 254
M+E+ R+ + + + +FQ + V E + ++ F+
Sbjct: 358 LTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHV---SYQETQQMQMKFQ----- 409
Query: 255 AEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGA 314
QV E I L +++D AV + E+N ++ A L + L
Sbjct: 410 --QVREQMEAEIAHLKQENGILRD--AVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
Query: 315 LKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ----QASLQSEN 370
KL + V K+ E + +QL E ++ EE+ +I+ + Q LQS+
Sbjct: 466 TGKL---QQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
Query: 371 IYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQL 430
+ E+E Q L KL Q+ E +L +L E R+ +EE L + + E L
Sbjct: 523 VAKENEVQSLHSKLTDTLVSKQQLEQRL-MQLMESEQKRVNKEESLQMQVQDILEQNEAL 581
Query: 431 ETY----------RKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAAR----TAERNL 476
+ + A L EEL + + KQ+ K+ D+ + R + E L
Sbjct: 582 KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI----KQTEDSLASERDRLTSKEEEL 637
Query: 477 SDLRKEN 483
D++ N
Sbjct: 638 KDIQNMN 644
Score = 52.8 bits (125), Expect = 1e-06
Identities = 112/441 (25%), Positives = 192/441 (43%), Gaps = 49/441 (11%)
Query: 70 LYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLE 129
L G+E+++ T+ ++EEK K L K + + E+ A ++ A +
Sbjct: 868 LLKGKEEQMN-TMKAVLEEKEKDLANTG---KWLQDLQEENESLKAHVQEVAQHNLKEAS 923
Query: 130 ATC--EKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQ 187
+ E+L E E+E+ LE LKE +S S + +L+ D+ +DE+K KSQ
Sbjct: 924 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV-------QDENKLFKSQ 976
Query: 188 IAEAK----IICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNK 243
I + K +F EE + I + E S L L + E + + ++L +
Sbjct: 977 IEQLKQQNYQQASSFPPHEELLKV-ISEREKEISGLWNELDSL-KDAVEHQRKKNNDLRE 1034
Query: 244 QKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLE-EDTTDDDNLELEVNSQWE 302
+ ++ E++L DK N T + +A LE ++ ++ V S
Sbjct: 1035 KNWEAMEALASTEKMLQDKVNK----TSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1090
Query: 303 NGANLDDPLKGALKKLIHAAKLNVSLKSL-----EGERNHIIIQLSEVDKTKEELTEHIK 357
G L K A K+ + + +K L E + H ++QL E +K K L E
Sbjct: 1091 YGEWLHGFEKKA-KECMAGTSGSEEVKVLEHKLKEADEMHTLLQL-ECEKYKSVLAETEG 1148
Query: 358 NLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVE---ENYRIEEEE 414
LQ Q S++ E ++ + + + +K M + +E +L R + EN R E E
Sbjct: 1149 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE- 1207
Query: 415 KLSRVEEKLSRATEQLETY----RKLAKDLEEELERTV-HFYQKQVISYEKRGHDNWLAA 469
+E +L +A + TY R+L KDL EL++ + Y + V E+ N L A
Sbjct: 1208 ---HLEMELEKAEMERSTYVTEVREL-KDLLTELQKKLDDSYSEAVRQNEEL---NLLKA 1260
Query: 470 RTAERNLSDLRKENAHNKQKL 490
+ E L+ LR E + +QK+
Sbjct: 1261 QLNE-TLTKLRTEQ-NERQKV 1279
Score = 32.0 bits (71), Expect = 2.3
Identities = 31/143 (21%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 99 IQKEYEGYEVESSL---EDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKE 155
++ E E E+E S E + E + L+ + + R N EL L + L +
Sbjct: 1209 LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK 1268
Query: 156 EKSKHSQQDELMADISKSIQSLE-DESKSLKSQ-----IAEAKIICKTFKMSEERRAIAI 209
+++ +++ ++ D+ K+ QSLE +SK +K+ I + + +T +E ++++
Sbjct: 1269 LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1328
Query: 210 KDALNENSQLQTSHKQLFQQEAE 232
+ + QL + Q +E E
Sbjct: 1329 NQTVTQLQQLLQAVNQQLTKEKE 1351
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 75.1 bits (183), Expect = 2e-13
Identities = 98/475 (20%), Positives = 197/475 (41%), Gaps = 66/475 (13%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARS-LEATCE 133
E K A L+ L ++ +L+ + + E L+ +K AE+A + L+ +
Sbjct: 441 ESKQSAELNKLRQDYARLVNELT---------EKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
+ R E++ I + + ++ + D+ + E+E +SL S++ + +
Sbjct: 492 EAERRWEEVQSYI----------RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 194 ICKTFKMSEERRAIAIKDA----LNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFE 249
K E+R + + ++ +N+ LQ + + +Q E K Q+ + + Q
Sbjct: 542 S----KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN-EALKAQIQQFHSQIAAQT 596
Query: 250 DSKVHAEQ---VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
+ V AE+ V+ +K+ IK L +D+ EE+ D N+
Sbjct: 597 SASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL---------- 646
Query: 307 LDDPLKGALKKLIHAAKLNVSLK-SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQAS 365
LK ++KL A + LE + + ++ ++ +E+L I N +
Sbjct: 647 ----LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI 702
Query: 366 LQSENIYFESENQKLQ---------QKLKIMTEFYQENEMKLYRKLTVEENYRIE---EE 413
L +N +SE QKLQ ++ M + QE + KL + E I+ +E
Sbjct: 703 LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKD------LEEELERTVHFYQKQVISYEKRGHDNWL 467
E+L+ + + S T++++ + D L EEL++ +H ++ S E+ L
Sbjct: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
Query: 468 AARTAERNLSDLRKENAHNKQKLTETEL-KFELLEKDPNALDVSNTAFGREHAPN 521
E+ + DL++E K+++ +L K + L ++ N G+E N
Sbjct: 823 KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMN 877
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/383 (20%), Positives = 168/383 (43%), Gaps = 38/383 (9%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEK--AAAEEARSLEAT 131
+++++ T L E+ +L K ++E + + + L A +K A A E +
Sbjct: 612 KDKQIKQTEDSLASERDRLTSK----EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
Query: 132 CEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEA 191
EK+ +S +D+I LE+ L+ E S ++ +++ D +K+++S + ++L S+
Sbjct: 668 LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Query: 192 KIICKTFKMSEER-RAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQ------ 244
++ + K +E+ + + L E +Q + K ++E + + S L K+
Sbjct: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATK---EEELNAIRTENSSLTKEVQDLKA 784
Query: 245 ----KITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
+++F ++V+++K+ IK++ L + A E+ D L+ E+ +
Sbjct: 785 KQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQD---LKQEIKAL 841
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
E N+ L +L LK E + N + L E +K + +++LQ
Sbjct: 842 KEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 901
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
+ SL++ + Q LK + Q E+++ K E+E +L R+E
Sbjct: 902 EENESLKAH------VQEVAQHNLKEASSASQFEELEIVLK---------EKENELKRLE 946
Query: 421 EKLSRATEQLETYRKLAKDLEEE 443
L L + +L +D+++E
Sbjct: 947 AMLKERESDLSSKTQLLQDVQDE 969
Score = 60.1 bits (144), Expect = 8e-09
Identities = 89/392 (22%), Positives = 174/392 (44%), Gaps = 50/392 (12%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEAT--C 132
+Q+L L L+E + K + K +Q + + ++ A ++ ++ A A+
Sbjct: 543 KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 602
Query: 133 EKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAK 192
E+L++ +E + +I E L E+ + + ++E + DI L+ E + L++ E
Sbjct: 603 EELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQA 662
Query: 193 IICKTFKMSEERRAIAIKD----ALNENSQLQTSHK----QLFQQEAEVWKGQVSELNK- 243
++ + ++++ +KD L E Q + S+K ++ + + K +V +L
Sbjct: 663 --AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 244 -QKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT----TDDDNLELEVN 298
+ +D E+ + +K+ +KT+ L Q A EE+ T++ +L EV
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 299 S--QWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHI 356
+N L LKK+IH + + +KS+E +++++ +KT ++L + I
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIH--EKDGKIKSVEELLEAELLKVANKEKTVQDLKQEI 838
Query: 357 KNLQTQQASLQSEN---IYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
K L+ + ++Q E + S+ Q+LQ LK E Q N MK +EE+
Sbjct: 839 KALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEE--QMNTMKAV----------LEEK 886
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEEELE 445
EK L K +DL+EE E
Sbjct: 887 EK-------------DLANTGKWLQDLQEENE 905
Score = 57.4 bits (137), Expect = 5e-08
Identities = 84/367 (22%), Positives = 146/367 (39%), Gaps = 46/367 (12%)
Query: 143 EDEILCLEKDLKEEKS--KHSQQDELMADISKSIQSLEDESKSL---KSQIAEAKIICKT 197
EDE LC+ LKE+ + + + +++ I L+++ K L K A K CK
Sbjct: 298 EDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ 357
Query: 198 FK---MSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVH 254
M+E+ R+ + + + +FQ + V E + ++ F+
Sbjct: 358 LTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHV---SYQETQQMQMKFQ----- 409
Query: 255 AEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGA 314
QV E I L +++D AV + E+N ++ A L + L
Sbjct: 410 --QVREQMEAEIAHLKQENGILRD--AVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
Query: 315 LKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ----QASLQSEN 370
KL + V K+ E + +QL E ++ EE+ +I+ + Q LQS+
Sbjct: 466 TGKL---QQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
Query: 371 IYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQL 430
+ E+E Q L KL Q+ E +L +L E R+ +EE L + + E L
Sbjct: 523 VAKENEVQSLHSKLTDTLVSKQQLEQRL-MQLMESEQKRVNKEESLQMQVQDILEQNEAL 581
Query: 431 ETY----------RKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAAR----TAERNL 476
+ + A L EEL + + KQ+ K+ D+ + R + E L
Sbjct: 582 KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI----KQTEDSLASERDRLTSKEEEL 637
Query: 477 SDLRKEN 483
D++ N
Sbjct: 638 KDIQNMN 644
Score = 52.8 bits (125), Expect = 1e-06
Identities = 112/441 (25%), Positives = 192/441 (43%), Gaps = 49/441 (11%)
Query: 70 LYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLE 129
L G+E+++ T+ ++EEK K L K + + E+ A ++ A +
Sbjct: 868 LLKGKEEQMN-TMKAVLEEKEKDLANTG---KWLQDLQEENESLKAHVQEVAQHNLKEAS 923
Query: 130 ATC--EKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQ 187
+ E+L E E+E+ LE LKE +S S + +L+ D+ +DE+K KSQ
Sbjct: 924 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV-------QDENKLFKSQ 976
Query: 188 IAEAK----IICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNK 243
I + K +F EE + I + E S L L + E + + ++L +
Sbjct: 977 IEQLKQQNYQQASSFPPHEELLKV-ISEREKEISGLWNELDSL-KDAVEHQRKKNNDLRE 1034
Query: 244 QKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLE-EDTTDDDNLELEVNSQWE 302
+ ++ E++L DK N T + +A LE ++ ++ V S
Sbjct: 1035 KNWEAMEALASTEKMLQDKVNK----TSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1090
Query: 303 NGANLDDPLKGALKKLIHAAKLNVSLKSL-----EGERNHIIIQLSEVDKTKEELTEHIK 357
G L K A K+ + + +K L E + H ++QL E +K K L E
Sbjct: 1091 YGEWLHGFEKKA-KECMAGTSGSEEVKVLEHKLKEADEMHTLLQL-ECEKYKSVLAETEG 1148
Query: 358 NLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVE---ENYRIEEEE 414
LQ Q S++ E ++ + + + +K M + +E +L R + EN R E E
Sbjct: 1149 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE- 1207
Query: 415 KLSRVEEKLSRATEQLETY----RKLAKDLEEELERTV-HFYQKQVISYEKRGHDNWLAA 469
+E +L +A + TY R+L KDL EL++ + Y + V E+ N L A
Sbjct: 1208 ---HLEMELEKAEMERSTYVTEVREL-KDLLTELQKKLDDSYSEAVRQNEEL---NLLKA 1260
Query: 470 RTAERNLSDLRKENAHNKQKL 490
+ E L+ LR E + +QK+
Sbjct: 1261 QLNE-TLTKLRTEQ-NERQKV 1279
Score = 32.0 bits (71), Expect = 2.3
Identities = 31/143 (21%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 99 IQKEYEGYEVESSL---EDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKE 155
++ E E E+E S E + E + L+ + + R N EL L + L +
Sbjct: 1209 LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK 1268
Query: 156 EKSKHSQQDELMADISKSIQSLE-DESKSLKSQ-----IAEAKIICKTFKMSEERRAIAI 209
+++ +++ ++ D+ K+ QSLE +SK +K+ I + + +T +E ++++
Sbjct: 1269 LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1328
Query: 210 KDALNENSQLQTSHKQLFQQEAE 232
+ + QL + Q +E E
Sbjct: 1329 NQTVTQLQQLLQAVNQQLTKEKE 1351
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 74.7 bits (182), Expect = 3e-13
Identities = 98/399 (24%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEAT 131
+E++L A L+ L +E + +K + ++K E EG+ + ED E+AA +A +
Sbjct: 1088 KEEELQAALARLDDE---IAQKNNALKKIRELEGH-ISDLQEDLDSERAARNKAEKQKRD 1143
Query: 132 C-EKLNRSNSELED-----------------EILCLEKDLKEEKSKHSQQDELMADISKS 173
E+L +ELED E+ L+K L EE H Q + M K
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ--KH 1201
Query: 174 IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV 233
Q++E+ ++ L+ Q AK K + E+ + L Q KQ + + +
Sbjct: 1202 AQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQA----KQEVEHKKKK 1256
Query: 234 WKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL 293
+ QV EL + E ++ ++ +N ++++TG L + +A L +D
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---- 1312
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS--LKSLEGERNHIIIQLSEVDKTKEE 351
++SQ ++ L L+ ++ KLNVS L+ LE ERN + QL E + K+
Sbjct: 1313 ---LSSQLQDTQEL---LQEETRQ-----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 352 LTEHIKNLQTQQASLQSENIYF-------ESENQKLQQKLKIMTEFYQENEMKLYRKLTV 404
L HI L Q + + + F E ++ Q++++ +T+ Y+E + Y KL
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE-KAAAYDKL-- 1418
Query: 405 EENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEE 443
E+ +R++++L L+ R+L +LE++
Sbjct: 1419 --------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Score = 67.8 bits (164), Expect = 4e-11
Identities = 80/390 (20%), Positives = 163/390 (41%), Gaps = 41/390 (10%)
Query: 118 EKAAAEEARSLEATCEKLN--RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQ 175
E+ A AR + +K N + ELE I L++DL E++ ++ ++ D+ + ++
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 176 SLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWK 235
+L+ E + A + + + E+ +K AL+E ++ SH+ Q+ +
Sbjct: 1150 ALKTELEDTLDSTATQQEL----RAKREQEVTVLKKALDEETR---SHEAQVQEMRQKHA 1202
Query: 236 GQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLEL 295
V EL +Q F+ +K + ++ E L G L ++ +E +
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Query: 296 EVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEH 355
E+ S+ +G A+LN + L+ E + L+E + +L +
Sbjct: 1263 ELQSKCSDGERA-------------RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 356 IKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQ--ENEMKLYRKLTVEENYRIEEE 413
+ +L +Q Q E ++ +QKL + T+ Q E L +L E + E
Sbjct: 1310 VASLSSQLQDTQ------ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEE-------ELERTVHFYQKQVISYEKRGHDNW 466
+S + +LS + ++L+ + + LEE E+E Y+++ +Y+K
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK--- 1420
Query: 467 LAARTAERNLSDLRKENAHNKQKLTETELK 496
++ L DL + + +Q ++ E K
Sbjct: 1421 -TKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Score = 65.5 bits (158), Expect = 2e-10
Identities = 100/453 (22%), Positives = 184/453 (40%), Gaps = 74/453 (16%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSL---EATCEKLNRSNSELE 143
E K K LE L+ + + S E E+ ++ +L E + L + ++ E
Sbjct: 977 EAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
I LE LK+E+ + ++L + ++ L++QIAE K+ + K EE
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM--QLAKKEEE 1091
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKE 263
+A A+ +E +Q + K++ + E G +S+L + + ++ AE+ D
Sbjct: 1092 LQA-ALARLDDEIAQKNNALKKIRELE-----GHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAK 323
++ L L EDT D + E+ ++ E + LKK +
Sbjct: 1146 EELEALKTEL-----------EDTLDSTATQQELRAKREQEVTV-------LKKALDEET 1187
Query: 324 LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
+ + E + H + EELTE ++ + +A+L E EN L +
Sbjct: 1188 RSHEAQVQEMRQKHA--------QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 384 LKIMTEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETY 433
L+++ + QE E K L K + E R E +K+ +++ ++ T L
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 434 R----KLAKD---LEEELERTVHFYQKQV------------ISYEKRGHDNWL-----AA 469
KLAKD L +L+ T Q++ + E+ + L A
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ER++S L + + +K+KL + E LE+
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Score = 63.2 bits (152), Expect = 9e-10
Identities = 91/436 (20%), Positives = 185/436 (42%), Gaps = 39/436 (8%)
Query: 78 LGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEA-RSLEATCEKLN 136
L L +E K +L +++ E E ++ SS +D E++ R+LE E++
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 137 RSNSELEDEILCLEK-DLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
ELEDE+ E L+ E + + + + D+ + E++ + L+ Q+ E +
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET-- 1603
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG------QVSELNKQKITF- 248
++ +ER+ A+ A + +L+ K L Q KG Q+ +L Q F
Sbjct: 1604 ---ELEDERKQRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 249 ---EDSKVHAEQVL---NDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE 302
ED++ +++ + E K+L L +++ A E D + E+ +
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 303 NGANLDDPLKGALKKL-IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQT 361
+ + + L+ ++L A+L L+ +G + ++ + + E+L+ + ++
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 362 QQASLQSENIYFESENQKLQQKLKIMT----EFYQENEMKLYRKLT-VEENYRIEEEEK- 415
+S E +N++L+ KL M ++ L K+ +EE E EK
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 416 -----LSRVEEKLSRATEQLETYRKLAKDLEEELER---TVHFYQKQVISYEKRGHDNWL 467
L + ++KL Q+E RK+A+ +E+ E+ V ++Q+ E+
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 468 AARTAERNLSDLRKEN 483
R +R L + + N
Sbjct: 1899 NRRKLQRELDEATESN 1914
Score = 55.5 bits (132), Expect = 2e-07
Identities = 101/491 (20%), Positives = 199/491 (40%), Gaps = 89/491 (18%)
Query: 91 KLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE---KLNRSNSELEDEIL 147
+LL + I +Y + E E A AR+LE E +L R+N L+ E+
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM- 1513
Query: 148 CLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFK-------- 199
+DL K D+ K++ LE ++L++Q+ E K + +
Sbjct: 1514 ---EDLVSSKD----------DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 200 ------------MSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV----WKGQVSELNK 243
+ R + +D NE + Q +QL + E E+ + ++ K
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-QRQLHEYETELEDERKQRALAAAAK 1619
Query: 244 QKI--TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD---------- 291
+K+ +D ++ A+ + +E IK L MKD LE+ D
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 292 ----NLELEVNSQWENGANLDDPLKGA-LKKLIHAAKLNVSL---KSLEGERNHIIIQLS 343
+LE ++ E+ A + K A L+K A +L SL +L+ E+ + +++
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 344 EVDKTKEE--------------LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
++++ EE T+ + L + A+ +S ES Q+L+++ K +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELER--- 446
E E + K ++ E K++++EE++ + + + K K +++L+
Sbjct: 1800 KLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 447 TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNA 506
V +K Y+++ + +R L + +E+ Q++ K L+++ +
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES----QRINANRRK---LQRELDE 1909
Query: 507 LDVSNTAFGRE 517
SN A GRE
Sbjct: 1910 ATESNEAMGRE 1920
Score = 39.7 bits (91), Expect = 0.011
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 12/173 (6%)
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLT 403
E+ KTKE + + + L+ ++ E LQ++L+ TE Y E E R
Sbjct: 860 ELQKTKERQ----QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 404 VEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAK---DLEEELERTVHFYQKQVISYEK 460
++ E +R+EE+ R + +K+A+ DLEE+LE QK + EK
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEK 973
Query: 461 RGHDNWLAARTAERNLSDLRKENAHNKQKLTE---TELKFELLEKDPNALDVS 510
+ + E + D + ++KL E ++L L E++ A +++
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 74.7 bits (182), Expect = 3e-13
Identities = 98/399 (24%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEAT 131
+E++L A L+ L +E + +K + ++K E EG+ + ED E+AA +A +
Sbjct: 1095 KEEELQAALARLDDE---IAQKNNALKKIRELEGH-ISDLQEDLDSERAARNKAEKQKRD 1150
Query: 132 C-EKLNRSNSELED-----------------EILCLEKDLKEEKSKHSQQDELMADISKS 173
E+L +ELED E+ L+K L EE H Q + M K
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ--KH 1208
Query: 174 IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV 233
Q++E+ ++ L+ Q AK K + E+ + L Q KQ + + +
Sbjct: 1209 AQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQA----KQEVEHKKKK 1263
Query: 234 WKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL 293
+ QV EL + E ++ ++ +N ++++TG L + +A L +D
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---- 1319
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS--LKSLEGERNHIIIQLSEVDKTKEE 351
++SQ ++ L L+ ++ KLNVS L+ LE ERN + QL E + K+
Sbjct: 1320 ---LSSQLQDTQEL---LQEETRQ-----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 352 LTEHIKNLQTQQASLQSENIYF-------ESENQKLQQKLKIMTEFYQENEMKLYRKLTV 404
L HI L Q + + + F E ++ Q++++ +T+ Y+E + Y KL
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE-KAAAYDKL-- 1425
Query: 405 EENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEE 443
E+ +R++++L L+ R+L +LE++
Sbjct: 1426 --------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Score = 67.8 bits (164), Expect = 4e-11
Identities = 80/390 (20%), Positives = 163/390 (41%), Gaps = 41/390 (10%)
Query: 118 EKAAAEEARSLEATCEKLN--RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQ 175
E+ A AR + +K N + ELE I L++DL E++ ++ ++ D+ + ++
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 176 SLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWK 235
+L+ E + A + + + E+ +K AL+E ++ SH+ Q+ +
Sbjct: 1157 ALKTELEDTLDSTATQQEL----RAKREQEVTVLKKALDEETR---SHEAQVQEMRQKHA 1209
Query: 236 GQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLEL 295
V EL +Q F+ +K + ++ E L G L ++ +E +
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Query: 296 EVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEH 355
E+ S+ +G A+LN + L+ E + L+E + +L +
Sbjct: 1270 ELQSKCSDGERA-------------RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 356 IKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQ--ENEMKLYRKLTVEENYRIEEE 413
+ +L +Q Q E ++ +QKL + T+ Q E L +L E + E
Sbjct: 1317 VASLSSQLQDTQ------ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEE-------ELERTVHFYQKQVISYEKRGHDNW 466
+S + +LS + ++L+ + + LEE E+E Y+++ +Y+K
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK--- 1427
Query: 467 LAARTAERNLSDLRKENAHNKQKLTETELK 496
++ L DL + + +Q ++ E K
Sbjct: 1428 -TKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Score = 65.5 bits (158), Expect = 2e-10
Identities = 100/453 (22%), Positives = 184/453 (40%), Gaps = 74/453 (16%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSL---EATCEKLNRSNSELE 143
E K K LE L+ + + S E E+ ++ +L E + L + ++ E
Sbjct: 984 EAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
I LE LK+E+ + ++L + ++ L++QIAE K+ + K EE
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM--QLAKKEEE 1098
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKE 263
+A A+ +E +Q + K++ + E G +S+L + + ++ AE+ D
Sbjct: 1099 LQA-ALARLDDEIAQKNNALKKIRELE-----GHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAK 323
++ L L EDT D + E+ ++ E + LKK +
Sbjct: 1153 EELEALKTEL-----------EDTLDSTATQQELRAKREQEVTV-------LKKALDEET 1194
Query: 324 LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
+ + E + H + EELTE ++ + +A+L E EN L +
Sbjct: 1195 RSHEAQVQEMRQKHA--------QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 384 LKIMTEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETY 433
L+++ + QE E K L K + E R E +K+ +++ ++ T L
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 434 R----KLAKD---LEEELERTVHFYQKQV------------ISYEKRGHDNWL-----AA 469
KLAKD L +L+ T Q++ + E+ + L A
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ER++S L + + +K+KL + E LE+
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Score = 63.2 bits (152), Expect = 9e-10
Identities = 91/436 (20%), Positives = 185/436 (42%), Gaps = 39/436 (8%)
Query: 78 LGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEA-RSLEATCEKLN 136
L L +E K +L +++ E E ++ SS +D E++ R+LE E++
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 137 RSNSELEDEILCLEK-DLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
ELEDE+ E L+ E + + + + D+ + E++ + L+ Q+ E +
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET-- 1610
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG------QVSELNKQKITF- 248
++ +ER+ A+ A + +L+ K L Q KG Q+ +L Q F
Sbjct: 1611 ---ELEDERKQRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 249 ---EDSKVHAEQVL---NDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE 302
ED++ +++ + E K+L L +++ A E D + E+ +
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 303 NGANLDDPLKGALKKL-IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQT 361
+ + + L+ ++L A+L L+ +G + ++ + + E+L+ + ++
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 362 QQASLQSENIYFESENQKLQQKLKIMT----EFYQENEMKLYRKLT-VEENYRIEEEEK- 415
+S E +N++L+ KL M ++ L K+ +EE E EK
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 416 -----LSRVEEKLSRATEQLETYRKLAKDLEEELER---TVHFYQKQVISYEKRGHDNWL 467
L + ++KL Q+E RK+A+ +E+ E+ V ++Q+ E+
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 468 AARTAERNLSDLRKEN 483
R +R L + + N
Sbjct: 1906 NRRKLQRELDEATESN 1921
Score = 55.5 bits (132), Expect = 2e-07
Identities = 101/491 (20%), Positives = 199/491 (40%), Gaps = 89/491 (18%)
Query: 91 KLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE---KLNRSNSELEDEIL 147
+LL + I +Y + E E A AR+LE E +L R+N L+ E+
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM- 1520
Query: 148 CLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFK-------- 199
+DL K D+ K++ LE ++L++Q+ E K + +
Sbjct: 1521 ---EDLVSSKD----------DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 200 ------------MSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV----WKGQVSELNK 243
+ R + +D NE + Q +QL + E E+ + ++ K
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-QRQLHEYETELEDERKQRALAAAAK 1626
Query: 244 QKI--TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD---------- 291
+K+ +D ++ A+ + +E IK L MKD LE+ D
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 292 ----NLELEVNSQWENGANLDDPLKGA-LKKLIHAAKLNVSL---KSLEGERNHIIIQLS 343
+LE ++ E+ A + K A L+K A +L SL +L+ E+ + +++
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 344 EVDKTKEE--------------LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
++++ EE T+ + L + A+ +S ES Q+L+++ K +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELER--- 446
E E + K ++ E K++++EE++ + + + K K +++L+
Sbjct: 1807 KLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 447 TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNA 506
V +K Y+++ + +R L + +E+ Q++ K L+++ +
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES----QRINANRRK---LQRELDE 1916
Query: 507 LDVSNTAFGRE 517
SN A GRE
Sbjct: 1917 ATESNEAMGRE 1927
Score = 39.7 bits (91), Expect = 0.011
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 12/173 (6%)
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLT 403
E+ KTKE + + + L+ ++ E LQ++L+ TE Y E E R
Sbjct: 867 ELQKTKERQ----QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 404 VEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAK---DLEEELERTVHFYQKQVISYEK 460
++ E +R+EE+ R + +K+A+ DLEE+LE QK + EK
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEK 980
Query: 461 RGHDNWLAARTAERNLSDLRKENAHNKQKLTE---TELKFELLEKDPNALDVS 510
+ + E + D + ++KL E ++L L E++ A +++
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 74.7 bits (182), Expect = 3e-13
Identities = 98/399 (24%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEAT 131
+E++L A L+ L +E + +K + ++K E EG+ + ED E+AA +A +
Sbjct: 1095 KEEELQAALARLDDE---IAQKNNALKKIRELEGH-ISDLQEDLDSERAARNKAEKQKRD 1150
Query: 132 C-EKLNRSNSELED-----------------EILCLEKDLKEEKSKHSQQDELMADISKS 173
E+L +ELED E+ L+K L EE H Q + M K
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ--KH 1208
Query: 174 IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV 233
Q++E+ ++ L+ Q AK K + E+ + L Q KQ + + +
Sbjct: 1209 AQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQA----KQEVEHKKKK 1263
Query: 234 WKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL 293
+ QV EL + E ++ ++ +N ++++TG L + +A L +D
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---- 1319
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS--LKSLEGERNHIIIQLSEVDKTKEE 351
++SQ ++ L L+ ++ KLNVS L+ LE ERN + QL E + K+
Sbjct: 1320 ---LSSQLQDTQEL---LQEETRQ-----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 352 LTEHIKNLQTQQASLQSENIYF-------ESENQKLQQKLKIMTEFYQENEMKLYRKLTV 404
L HI L Q + + + F E ++ Q++++ +T+ Y+E + Y KL
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE-KAAAYDKL-- 1425
Query: 405 EENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEE 443
E+ +R++++L L+ R+L +LE++
Sbjct: 1426 --------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Score = 67.8 bits (164), Expect = 4e-11
Identities = 80/390 (20%), Positives = 163/390 (41%), Gaps = 41/390 (10%)
Query: 118 EKAAAEEARSLEATCEKLN--RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQ 175
E+ A AR + +K N + ELE I L++DL E++ ++ ++ D+ + ++
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 176 SLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWK 235
+L+ E + A + + + E+ +K AL+E ++ SH+ Q+ +
Sbjct: 1157 ALKTELEDTLDSTATQQEL----RAKREQEVTVLKKALDEETR---SHEAQVQEMRQKHA 1209
Query: 236 GQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLEL 295
V EL +Q F+ +K + ++ E L G L ++ +E +
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Query: 296 EVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEH 355
E+ S+ +G A+LN + L+ E + L+E + +L +
Sbjct: 1270 ELQSKCSDGERA-------------RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 356 IKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQ--ENEMKLYRKLTVEENYRIEEE 413
+ +L +Q Q E ++ +QKL + T+ Q E L +L E + E
Sbjct: 1317 VASLSSQLQDTQ------ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEE-------ELERTVHFYQKQVISYEKRGHDNW 466
+S + +LS + ++L+ + + LEE E+E Y+++ +Y+K
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK--- 1427
Query: 467 LAARTAERNLSDLRKENAHNKQKLTETELK 496
++ L DL + + +Q ++ E K
Sbjct: 1428 -TKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Score = 65.5 bits (158), Expect = 2e-10
Identities = 100/453 (22%), Positives = 184/453 (40%), Gaps = 74/453 (16%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSL---EATCEKLNRSNSELE 143
E K K LE L+ + + S E E+ ++ +L E + L + ++ E
Sbjct: 984 EAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
I LE LK+E+ + ++L + ++ L++QIAE K+ + K EE
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM--QLAKKEEE 1098
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKE 263
+A A+ +E +Q + K++ + E G +S+L + + ++ AE+ D
Sbjct: 1099 LQA-ALARLDDEIAQKNNALKKIRELE-----GHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAK 323
++ L L EDT D + E+ ++ E + LKK +
Sbjct: 1153 EELEALKTEL-----------EDTLDSTATQQELRAKREQEVTV-------LKKALDEET 1194
Query: 324 LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
+ + E + H + EELTE ++ + +A+L E EN L +
Sbjct: 1195 RSHEAQVQEMRQKHA--------QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 384 LKIMTEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETY 433
L+++ + QE E K L K + E R E +K+ +++ ++ T L
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 434 R----KLAKD---LEEELERTVHFYQKQV------------ISYEKRGHDNWL-----AA 469
KLAKD L +L+ T Q++ + E+ + L A
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ER++S L + + +K+KL + E LE+
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Score = 63.2 bits (152), Expect = 9e-10
Identities = 91/436 (20%), Positives = 185/436 (42%), Gaps = 39/436 (8%)
Query: 78 LGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEA-RSLEATCEKLN 136
L L +E K +L +++ E E ++ SS +D E++ R+LE E++
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 137 RSNSELEDEILCLEK-DLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
ELEDE+ E L+ E + + + + D+ + E++ + L+ Q+ E +
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET-- 1610
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG------QVSELNKQKITF- 248
++ +ER+ A+ A + +L+ K L Q KG Q+ +L Q F
Sbjct: 1611 ---ELEDERKQRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 249 ---EDSKVHAEQVL---NDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE 302
ED++ +++ + E K+L L +++ A E D + E+ +
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 303 NGANLDDPLKGALKKL-IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQT 361
+ + + L+ ++L A+L L+ +G + ++ + + E+L+ + ++
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 362 QQASLQSENIYFESENQKLQQKLKIMT----EFYQENEMKLYRKLT-VEENYRIEEEEK- 415
+S E +N++L+ KL M ++ L K+ +EE E EK
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 416 -----LSRVEEKLSRATEQLETYRKLAKDLEEELER---TVHFYQKQVISYEKRGHDNWL 467
L + ++KL Q+E RK+A+ +E+ E+ V ++Q+ E+
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 468 AARTAERNLSDLRKEN 483
R +R L + + N
Sbjct: 1906 NRRKLQRELDEATESN 1921
Score = 55.5 bits (132), Expect = 2e-07
Identities = 101/491 (20%), Positives = 199/491 (40%), Gaps = 89/491 (18%)
Query: 91 KLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE---KLNRSNSELEDEIL 147
+LL + I +Y + E E A AR+LE E +L R+N L+ E+
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM- 1520
Query: 148 CLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFK-------- 199
+DL K D+ K++ LE ++L++Q+ E K + +
Sbjct: 1521 ---EDLVSSKD----------DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 200 ------------MSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV----WKGQVSELNK 243
+ R + +D NE + Q +QL + E E+ + ++ K
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-QRQLHEYETELEDERKQRALAAAAK 1626
Query: 244 QKI--TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD---------- 291
+K+ +D ++ A+ + +E IK L MKD LE+ D
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 292 ----NLELEVNSQWENGANLDDPLKGA-LKKLIHAAKLNVSL---KSLEGERNHIIIQLS 343
+LE ++ E+ A + K A L+K A +L SL +L+ E+ + +++
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 344 EVDKTKEE--------------LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
++++ EE T+ + L + A+ +S ES Q+L+++ K +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELER--- 446
E E + K ++ E K++++EE++ + + + K K +++L+
Sbjct: 1807 KLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 447 TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNA 506
V +K Y+++ + +R L + +E+ Q++ K L+++ +
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES----QRINANRRK---LQRELDE 1916
Query: 507 LDVSNTAFGRE 517
SN A GRE
Sbjct: 1917 ATESNEAMGRE 1927
Score = 39.7 bits (91), Expect = 0.011
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 12/173 (6%)
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLT 403
E+ KTKE + + + L+ ++ E LQ++L+ TE Y E E R
Sbjct: 867 ELQKTKERQ----QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 404 VEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAK---DLEEELERTVHFYQKQVISYEK 460
++ E +R+EE+ R + +K+A+ DLEE+LE QK + EK
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEK 980
Query: 461 RGHDNWLAARTAERNLSDLRKENAHNKQKLTE---TELKFELLEKDPNALDVS 510
+ + E + D + ++KL E ++L L E++ A +++
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 74.7 bits (182), Expect = 3e-13
Identities = 98/399 (24%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEAT 131
+E++L A L+ L +E + +K + ++K E EG+ + ED E+AA +A +
Sbjct: 1088 KEEELQAALARLDDE---IAQKNNALKKIRELEGH-ISDLQEDLDSERAARNKAEKQKRD 1143
Query: 132 C-EKLNRSNSELED-----------------EILCLEKDLKEEKSKHSQQDELMADISKS 173
E+L +ELED E+ L+K L EE H Q + M K
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ--KH 1201
Query: 174 IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV 233
Q++E+ ++ L+ Q AK K + E+ + L Q KQ + + +
Sbjct: 1202 AQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQA----KQEVEHKKKK 1256
Query: 234 WKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL 293
+ QV EL + E ++ ++ +N ++++TG L + +A L +D
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---- 1312
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS--LKSLEGERNHIIIQLSEVDKTKEE 351
++SQ ++ L L+ ++ KLNVS L+ LE ERN + QL E + K+
Sbjct: 1313 ---LSSQLQDTQEL---LQEETRQ-----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 352 LTEHIKNLQTQQASLQSENIYF-------ESENQKLQQKLKIMTEFYQENEMKLYRKLTV 404
L HI L Q + + + F E ++ Q++++ +T+ Y+E + Y KL
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE-KAAAYDKL-- 1418
Query: 405 EENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEE 443
E+ +R++++L L+ R+L +LE++
Sbjct: 1419 --------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Score = 67.8 bits (164), Expect = 4e-11
Identities = 80/390 (20%), Positives = 163/390 (41%), Gaps = 41/390 (10%)
Query: 118 EKAAAEEARSLEATCEKLN--RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQ 175
E+ A AR + +K N + ELE I L++DL E++ ++ ++ D+ + ++
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 176 SLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWK 235
+L+ E + A + + + E+ +K AL+E ++ SH+ Q+ +
Sbjct: 1150 ALKTELEDTLDSTATQQEL----RAKREQEVTVLKKALDEETR---SHEAQVQEMRQKHA 1202
Query: 236 GQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLEL 295
V EL +Q F+ +K + ++ E L G L ++ +E +
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Query: 296 EVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEH 355
E+ S+ +G A+LN + L+ E + L+E + +L +
Sbjct: 1263 ELQSKCSDGERA-------------RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 356 IKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQ--ENEMKLYRKLTVEENYRIEEE 413
+ +L +Q Q E ++ +QKL + T+ Q E L +L E + E
Sbjct: 1310 VASLSSQLQDTQ------ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 414 EKLSRVEEKLSRATEQLETYRKLAKDLEE-------ELERTVHFYQKQVISYEKRGHDNW 466
+S + +LS + ++L+ + + LEE E+E Y+++ +Y+K
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK--- 1420
Query: 467 LAARTAERNLSDLRKENAHNKQKLTETELK 496
++ L DL + + +Q ++ E K
Sbjct: 1421 -TKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Score = 65.5 bits (158), Expect = 2e-10
Identities = 100/453 (22%), Positives = 184/453 (40%), Gaps = 74/453 (16%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSL---EATCEKLNRSNSELE 143
E K K LE L+ + + S E E+ ++ +L E + L + ++ E
Sbjct: 977 EAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
I LE LK+E+ + ++L + ++ L++QIAE K+ + K EE
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM--QLAKKEEE 1091
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKE 263
+A A+ +E +Q + K++ + E G +S+L + + ++ AE+ D
Sbjct: 1092 LQA-ALARLDDEIAQKNNALKKIRELE-----GHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAK 323
++ L L EDT D + E+ ++ E + LKK +
Sbjct: 1146 EELEALKTEL-----------EDTLDSTATQQELRAKREQEVTV-------LKKALDEET 1187
Query: 324 LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
+ + E + H + EELTE ++ + +A+L E EN L +
Sbjct: 1188 RSHEAQVQEMRQKHA--------QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 384 LKIMTEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETY 433
L+++ + QE E K L K + E R E +K+ +++ ++ T L
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 434 R----KLAKD---LEEELERTVHFYQKQV------------ISYEKRGHDNWL-----AA 469
KLAKD L +L+ T Q++ + E+ + L A
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ER++S L + + +K+KL + E LE+
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Score = 63.2 bits (152), Expect = 9e-10
Identities = 91/436 (20%), Positives = 185/436 (42%), Gaps = 39/436 (8%)
Query: 78 LGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEA-RSLEATCEKLN 136
L L +E K +L +++ E E ++ SS +D E++ R+LE E++
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 137 RSNSELEDEILCLEK-DLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
ELEDE+ E L+ E + + + + D+ + E++ + L+ Q+ E +
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET-- 1603
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG------QVSELNKQKITF- 248
++ +ER+ A+ A + +L+ K L Q KG Q+ +L Q F
Sbjct: 1604 ---ELEDERKQRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 249 ---EDSKVHAEQVL---NDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE 302
ED++ +++ + E K+L L +++ A E D + E+ +
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 303 NGANLDDPLKGALKKL-IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQT 361
+ + + L+ ++L A+L L+ +G + ++ + + E+L+ + ++
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 362 QQASLQSENIYFESENQKLQQKLKIMT----EFYQENEMKLYRKLT-VEENYRIEEEEK- 415
+S E +N++L+ KL M ++ L K+ +EE E EK
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 416 -----LSRVEEKLSRATEQLETYRKLAKDLEEELER---TVHFYQKQVISYEKRGHDNWL 467
L + ++KL Q+E RK+A+ +E+ E+ V ++Q+ E+
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 468 AARTAERNLSDLRKEN 483
R +R L + + N
Sbjct: 1899 NRRKLQRELDEATESN 1914
Score = 55.5 bits (132), Expect = 2e-07
Identities = 101/491 (20%), Positives = 199/491 (40%), Gaps = 89/491 (18%)
Query: 91 KLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE---KLNRSNSELEDEIL 147
+LL + I +Y + E E A AR+LE E +L R+N L+ E+
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM- 1513
Query: 148 CLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFK-------- 199
+DL K D+ K++ LE ++L++Q+ E K + +
Sbjct: 1514 ---EDLVSSKD----------DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 200 ------------MSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV----WKGQVSELNK 243
+ R + +D NE + Q +QL + E E+ + ++ K
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-QRQLHEYETELEDERKQRALAAAAK 1619
Query: 244 QKI--TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD---------- 291
+K+ +D ++ A+ + +E IK L MKD LE+ D
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 292 ----NLELEVNSQWENGANLDDPLKGA-LKKLIHAAKLNVSL---KSLEGERNHIIIQLS 343
+LE ++ E+ A + K A L+K A +L SL +L+ E+ + +++
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 344 EVDKTKEE--------------LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
++++ EE T+ + L + A+ +S ES Q+L+++ K +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELER--- 446
E E + K ++ E K++++EE++ + + + K K +++L+
Sbjct: 1800 KLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 447 TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNA 506
V +K Y+++ + +R L + +E+ Q++ K L+++ +
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES----QRINANRRK---LQRELDE 1909
Query: 507 LDVSNTAFGRE 517
SN A GRE
Sbjct: 1910 ATESNEAMGRE 1920
Score = 39.7 bits (91), Expect = 0.011
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 12/173 (6%)
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLT 403
E+ KTKE + + + L+ ++ E LQ++L+ TE Y E E R
Sbjct: 860 ELQKTKERQ----QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 404 VEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAK---DLEEELERTVHFYQKQVISYEK 460
++ E +R+EE+ R + +K+A+ DLEE+LE QK + EK
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEK 973
Query: 461 RGHDNWLAARTAERNLSDLRKENAHNKQKLTE---TELKFELLEKDPNALDVS 510
+ + E + D + ++KL E ++L L E++ A +++
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 74.3 bits (181), Expect = 4e-13
Identities = 102/458 (22%), Positives = 192/458 (41%), Gaps = 54/458 (11%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE 133
R ++ G S IE K +F ++++ E ++ A+ K A+ L +
Sbjct: 1150 RLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQID 1209
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
L R +LE K+ E K + M +SKS +LE ++L+ Q++EA+
Sbjct: 1210 NLQRVKQKLE-------KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEAR- 1261
Query: 194 ICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKV 253
K E +R+++ + + S+LQT +L +Q E + VS+L++ K F
Sbjct: 1262 ----GKNEEIQRSLS--ELTTQKSRLQTEAGELSRQLEEK-ESIVSQLSRSKQAFTQQTE 1314
Query: 254 HAEQVLNDKENHIKTLTGH-LPMMKDQAAVLEEDTTDDDNLELEVN----------SQWE 302
++ L ++EN K H L + +L E ++ + E+ +QW
Sbjct: 1315 ELKRQL-EEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1373
Query: 303 NGANLD-----DPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIK 357
D + L+ A KKL A +L S + +E + + + ++KTK+ L ++
Sbjct: 1374 TKYETDAIQRTEELEEAKKKL--AQRLQDSEEQVEA----VNAKCASLEKTKQRLQGEVE 1427
Query: 358 NLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLS 417
+L S + + + + L +E++ +L L + E L
Sbjct: 1428 DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTE----LF 1483
Query: 418 RVEEKLSRATEQLETYRKLAKDLEEELE----------RTVHFYQKQVISYEKRGHDNWL 467
+++ A +QLET ++ K+LE+E+ +T+H +K E D L
Sbjct: 1484 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 1543
Query: 468 AARTAERNLSDLRKENAHNKQKLTE--TELKFELLEKD 503
A AE L + + +LT+ +E+ ++ EKD
Sbjct: 1544 ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKD 1581
Score = 67.0 bits (162), Expect = 6e-11
Identities = 105/477 (22%), Positives = 195/477 (40%), Gaps = 54/477 (11%)
Query: 63 FRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAA 122
F ++ L +K AT+ ++ L K +KE E V E +
Sbjct: 834 FFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ 893
Query: 123 EEARSL---EATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED 179
E+ +L E C++L ++ +LE +I KE + ++E+ A+++ + LED
Sbjct: 894 AESENLLDAEERCDQLIKAKFQLEAKI-------KEVTERAEDEEEINAELTAKKRKLED 946
Query: 180 ESKSLKSQIAEAKIIC------------KTFKMSEERRAI--AIKDALNENSQLQTSHKQ 225
E LK I + ++ K ++EE + I E LQ +H+Q
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 226 LFQQEAEVWKGQVSELNKQKITFE------DSKVHAEQVLN-DKENHIKTLTGHLPMMKD 278
+ + + +V+ LNK K E +S + E+ L D E + + L G L + ++
Sbjct: 1007 AL-DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 1065
Query: 279 QAAVLEEDTTD-DDNLE------LEVNSQWENGANLDDPLKGALKKL-IHAAKLNVSLKS 330
LE D D+ L+ ++ S+ E+ L + +K+L +L +++
Sbjct: 1066 SILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEA 1125
Query: 331 LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEF 390
R Q S+ + EEL+E ++ ++ N E+E KL++ L+ T
Sbjct: 1126 ERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQ 1185
Query: 391 YQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHF 450
++ L +K E+ + L RV++KL + + KL D +L ++
Sbjct: 1186 HEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF----KLEID---DLSSSMES 1238
Query: 451 YQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNAL 507
K + EK RT E LS+ R +N ++ L+E + L+ + L
Sbjct: 1239 VSKSKANLEK-------ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL 1288
Score = 53.5 bits (127), Expect = 7e-07
Identities = 80/408 (19%), Positives = 167/408 (40%), Gaps = 40/408 (9%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEATC 132
EQ++ A L+ I E K + + +K E E +++ +LE+A EEA+ L
Sbjct: 1507 EQEI-ADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAE-AALEHEEAKILRIQL 1564
Query: 133 E------KLNRSNSELEDEILCLEKD-----------LKEEKSKHSQQDELMADISKSIQ 175
E +++R +E ++EI L+++ L E ++ L + +
Sbjct: 1565 ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 1624
Query: 176 SLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWK 235
+E + Q AE ++ + + + + DAL L+ + ++ A + +
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK-EQLAIVERRANLLQ 1683
Query: 236 GQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGH------------LPMMKDQAAVL 283
+V EL E ++ AEQ L D ++ L +M+ Q+ V
Sbjct: 1684 AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV- 1742
Query: 284 EEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLS 343
E+ + D N E + + A + + LK H ++ +L+ + H + +
Sbjct: 1743 EDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Query: 344 EV-----DKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKL 398
++ K ++L I+ L+ + Q +N +K ++++K +T +E+ +
Sbjct: 1803 QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNV 1862
Query: 399 YRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELER 446
R + + +++ + + EE +A L +RK +LEE ER
Sbjct: 1863 LRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Score = 50.1 bits (118), Expect = 8e-06
Identities = 75/359 (20%), Positives = 137/359 (38%), Gaps = 46/359 (12%)
Query: 107 EVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDEL 166
EV S E +K + +E NR +E + ++ LK+ +
Sbjct: 1605 EVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG 1664
Query: 167 MADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQ- 225
D+ + + +E + L++++ E + T + +E R +A ++ L+ N ++Q H Q
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRA---TLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Query: 226 -------------LFQQEAEVWKGQVSELN---KQKITFEDSKVHAEQVLNDKENHIKTL 269
L Q ++EV N K K D+ + AE++ +++
Sbjct: 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT----- 1776
Query: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329
+ HL MK E T D L+ Q LKG K++ KL ++
Sbjct: 1777 SAHLERMKKNL----EQTVKDLQHRLDEAEQLA--------LKGGKKQI---QKLETRIR 1821
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
LE E + +E K + +K L Q + + + KLQ K+K
Sbjct: 1822 ELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKR 1881
Query: 390 FYQENEMKLYRKLTV--EENYRIEEEEKLSRVEE----KLSRATEQLETYRKLAKDLEE 442
+E + + LT + + +EE E+ + + E KL T + R + + EE
Sbjct: 1882 QAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Score = 44.7 bits (104), Expect = 3e-04
Identities = 88/427 (20%), Positives = 188/427 (44%), Gaps = 50/427 (11%)
Query: 87 EEKCKLLEKF-SLIQKEYEGYEVESSLEDASFEKAAAEE-ARSLEATCEKLNRSNSELED 144
E+K L K S ++++ E ++ESSLE + E R LE + S +LE+
Sbjct: 1015 EDKVNSLNKTKSKLEQQVE--DLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN 1072
Query: 145 EILCLEKDLKEE-------KSKHSQQDELMADISKSIQSLEDESKSLKSQI-AEAKIICK 196
+ L++ LK++ +SK + L K I+ L+ + L+ +I AE K
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 1132
Query: 197 TFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKV-HA 255
T E++R+ ++ L E S+ + + E+ K + +E K + E++ + H
Sbjct: 1133 T----EKQRSDYARE-LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHE 1187
Query: 256 EQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGAL 315
V ++ H ++ + + V ++ + +LE++ +L ++
Sbjct: 1188 AMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID-------DLSSSMESVS 1240
Query: 316 KKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFES 375
K + K+ ++LE + + + E+ ++ ELT LQT+ L
Sbjct: 1241 KSKANLEKI---CRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL--------- 1288
Query: 376 ENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKL-SRVEEKLSRATEQLETYR 434
+++L++K I+++ + + + + T E ++EEE K + + L + + R
Sbjct: 1289 -SRQLEEKESIVSQLSRSKQ--AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 1345
Query: 435 KLAKDLEE---ELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLT 491
+ ++ +E EL+R + +V + + ++ RT E L + +K+ A Q+L
Sbjct: 1346 EQYEEEQEGKAELQRALSKANSEVAQWRTK-YETDAIQRTEE--LEEAKKKLA---QRLQ 1399
Query: 492 ETELKFE 498
++E + E
Sbjct: 1400 DSEEQVE 1406
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 73.9 bits (180), Expect = 5e-13
Identities = 91/431 (21%), Positives = 196/431 (45%), Gaps = 80/431 (18%)
Query: 100 QKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSK 159
+ E ++ LE + + A E R L+ ++L + S+ E+++ L L E+++
Sbjct: 1362 EAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAA 1421
Query: 160 HSQ-QDELMA--DISKSIQS-LEDESKSLKSQIAEAKI-IC----KTFKMSEERRA---- 206
++ Q E++ D+ K++ + LE ++K +I + ++ +C K ++ EE RA
Sbjct: 1422 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQI 1481
Query: 207 --------IAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQV 258
I+ K+AL EN L Q+E + +G + L K E S+V A+
Sbjct: 1482 QRKLQAALISRKEALKENKSL--------QEELSLARGTIERLTKSLADVE-SQVSAQNK 1532
Query: 259 LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL 318
D T+ G L +++++ D L E++ + L
Sbjct: 1533 EKD------TVLGRLALLQEER----------DKLITEMD-----------------RSL 1559
Query: 319 IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQ 378
+ L+ S +SL+ + L + + KE+L + I++L++ + +E+ ++ +++
Sbjct: 1560 LENQSLSSSCESLK-------LALEGLTEDKEKLVKEIESLKSSKI---AESTEWQEKHK 1609
Query: 379 KLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEE---KLSRVEEKLSRATEQLETYRK 435
+LQ++ +I+ + Y+ + R V E R E++E KL E +QL+ +
Sbjct: 1610 ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQ 1669
Query: 436 LAKDLEEELERTVHFYQKQVISYEKRGH----DNWLAARTAERNLSDLRKENAHNKQKLT 491
++++E++ + Q++++ E+ + A TA+ + L NA K++L
Sbjct: 1670 EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE 1729
Query: 492 ETELKFELLEK 502
++++E L K
Sbjct: 1730 RVKMEYETLSK 1740
Score = 59.3 bits (142), Expect = 1e-08
Identities = 90/460 (19%), Positives = 193/460 (41%), Gaps = 60/460 (13%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESSL-----EDASFEKAAAEEARSLEATCEKLNRSN 139
L E+ C +L K L Q E++ ++ + +E A E + + C+ L N
Sbjct: 2228 LKEDNCSVL-KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
Query: 140 SEL--------------EDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLK 185
EL ++E+ LE +LK K + + D+S S++ +++ +L+
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQ-------LTDLSNSLEKCKEQKGNLE 2339
Query: 186 SQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQK 245
I + + + K S E+ ++ + S+L H+++ +E ++ +S L+ ++
Sbjct: 2340 GIIRQQEADIQNSKFSYEQLETDLQASRELTSRL---HEEINMKEQKI----ISLLSGKE 2392
Query: 246 ITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT---TDDDNLELEV----- 297
E +V ++ + IK L L +++ VLEE+ D N +E
Sbjct: 2393 ---EAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK 2449
Query: 298 NSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQ----LSEVDKTKEELT 353
+ A LD +K ++ + LE II++ + E +L
Sbjct: 2450 KENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLK 2509
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEE- 412
E I+ L++ L SEN ++E + ++ L + ++++ K ++ +++N +E
Sbjct: 2510 EEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITI-KDSQQKQLLEVQLQQNKELENK 2568
Query: 413 ----EEKLSRVEEKLSRATEQLETYRKLAKDLEEELER---TVHFYQKQVISYEKRGHDN 465
EEKL EE ++ +DL +E+E ++ +QV + ++ G
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628
Query: 466 WLAA--RTAERNLSDLRKENAHNKQKLTETELKFELLEKD 503
A + E + L + +++++ E E + ++K+
Sbjct: 2629 LYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE 2668
Score = 58.9 bits (141), Expect = 2e-08
Identities = 75/374 (20%), Positives = 147/374 (39%), Gaps = 59/374 (15%)
Query: 119 KAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLE 178
K EE L A + +ELE+E++C++K+ +K + +E
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA-----------------AKKVGEIE 2677
Query: 179 DE-SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQ 237
D+ K LK +A I+ + +EER A +D + +L + +E + Q
Sbjct: 2678 DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLL-----MVTKENKGLTAQ 2732
Query: 238 VSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEV 297
+ + + ++S+ HA + L++ + L +K+Q + E +
Sbjct: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
Query: 298 NSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIK 357
NS EN L H KLN L S + + H+ QL E+ ++
Sbjct: 2793 NSTEENS-------------LSHLEKLNQQLLSKDEQLLHLSSQL-------EDSYNQVQ 2832
Query: 358 NLQTQQASLQSENIYFESENQKL------QQKLKIMTEFYQENEMKLYRKLTVEENYRIE 411
+ ASLQ+E + +E +K +Q+ L + ++ +N R
Sbjct: 2833 SFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDR 2892
Query: 412 EEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHD-NWLAAR 470
++L ++++ + +++ L L+E ++T F Q++ E R + +W
Sbjct: 2893 LLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF---QIMQEELRQENLSW---- 2945
Query: 471 TAERNLSDLRKENA 484
+ L LR E +
Sbjct: 2946 --QHELHQLRMEKS 2957
Score = 58.5 bits (140), Expect = 2e-08
Identities = 94/450 (20%), Positives = 177/450 (39%), Gaps = 81/450 (18%)
Query: 83 SGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSEL 142
S I E + EK +QKEYE + S E+ S EA ++ E + + EL
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYE--ILLQSYENVS------NEAERIQHVVEAVRQEKQEL 1646
Query: 143 EDEILCLE-------KDLKEEKSKHSQQDELMADISKSIQS----LEDESKSLKSQIAEA 191
++ E K L+E + + + E M +KS Q LE+E+ L++++ A
Sbjct: 1647 YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
Query: 192 ---------KIICKTFKMSEERRAIAIK-DALNENSQLQTSHKQLFQQEAEVWKGQVSEL 241
++ M EE + ++ + L++ Q S K +E + K Q+
Sbjct: 1707 GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGN 1766
Query: 242 NKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQW 301
++ E ++ H Q N E +++ G +T + D+L +
Sbjct: 1767 VSKQANLEATEKHDNQT-NVTEEGTQSIPG--------------ETEEQDSLSMSTRPTC 1811
Query: 302 ENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQT 361
A+ K S E N+ + Q+ ++L E I L+
Sbjct: 1812 SESVPSAKSANPAVSKDF----------SSHDEINNYLQQI-------DQLKERIAGLEE 1854
Query: 362 QQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEE 421
++ + + E+E L ++ ++ E+K+ ++ + N ++ ++E
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQIST-----KDGELKMLQEEVTKMNLLNQQ------IQE 1903
Query: 422 KLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRK 481
+LSR T+ ET + DLEE L + + +Y + D + E + +L+K
Sbjct: 1904 ELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKK 1963
Query: 482 ---ENAHNKQKL------TETELKFELLEK 502
E KQ+L E+E++ E LEK
Sbjct: 1964 CVSELEEEKQQLVKEKTKVESEIRKEYLEK 1993
Score = 56.6 bits (135), Expect = 9e-08
Identities = 86/401 (21%), Positives = 172/401 (42%), Gaps = 40/401 (9%)
Query: 82 LSGLIEEKCKLLEKFSLI------QKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKL 135
LS +E+ ++ FS ++++ E+E + ++ +A + + A + L
Sbjct: 2820 LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSL 2879
Query: 136 NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
++ S L+++ L K+LK + ++ Q I++ I L LK+Q+ E +
Sbjct: 2880 KKAMSSLQNDRDRLLKELKNLQQQYLQ-------INQEITELHP----LKAQLQEYQDKT 2928
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEA--EVWKGQVSELNKQKITFEDSKV 253
K F++ +E + EN Q QL +++ E+ + ++ E I+ +D ++
Sbjct: 2929 KAFQIMQE-------ELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL 2981
Query: 254 HAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKG 313
Q L + + T L + + A E + D + L ++ L+D LK
Sbjct: 2982 SHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLR-TQLNDSLKE 3040
Query: 314 ALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYF 373
+K + +LN + L E+N + IQL + ++ E +H +L A L+ +
Sbjct: 3041 IHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQ---- 3096
Query: 374 ESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETY 433
E Q + + QE ++RK EE E ++ S +++L +++
Sbjct: 3097 VQELQAGPLNIDVAPGAPQEKN-GVHRKSDPEE--LREPQQSFSEAQQQLCNTRQEVNEL 3153
Query: 434 RKLAKDLEEELERTVHFYQKQVISYE---KRGHDNWLAART 471
RKL LEEE ++ V ++ E + H W ++RT
Sbjct: 3154 RKL---LEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRT 3191
Score = 51.6 bits (122), Expect = 3e-06
Identities = 103/500 (20%), Positives = 205/500 (41%), Gaps = 77/500 (15%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEV---ESSLEDASFEKAAAEEARSLEAT 131
E++L ++EK + EK +++E E E + +K + +L++T
Sbjct: 2124 ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST 2183
Query: 132 CEKL---NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI 188
+L +S S L+D+ ++ + E K + + + + I+ ED LK Q+
Sbjct: 2184 VTQLAAFTKSMSSLQDD---RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240
Query: 189 AEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITF 248
+ I + K++ R D S+ QT QL Q+ + +G+ EL Q
Sbjct: 2241 RQMSIHMEELKINISRLE---HDKQIWESKAQTE-VQLQQKVCDTLQGENKELLSQ---L 2293
Query: 249 EDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAA----VLEEDTTDDDNLELEVNSQWENG 304
E+++ + + +N + L L +KDQ LE+ NLE + Q +
Sbjct: 2294 EETR----HLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADI 2349
Query: 305 AN-------LDDPLKGALKKLIHAAKLNVSLKS------LEGERNHIIIQLSEVDKTKEE 351
N L+ L+ A ++L +++K L G+ I + ++E+ + ++
Sbjct: 2350 QNSKFSYEQLETDLQ-ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDK 2408
Query: 352 LTEHIKNLQTQQASLQSENIYFESENQK-------------------LQQK------LKI 386
+ ++NL +Q+ + ENI E EN+K +QQK +K
Sbjct: 2409 EIKELENLLSQE---EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS 2465
Query: 387 MTEFYQENEMKLYRKLTVEENYR---IEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEE 443
M+ + + + +EE + +E+++ + + ++ E++ R DL E
Sbjct: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
Query: 444 ---LERTVHFYQK---QVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKF 497
L+ + Y++ QVI+ + L + + +L + A ++KL E+E
Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQN--KELENKYAKLEEKLKESEEAN 2583
Query: 498 ELLEKDPNALDVSNTAFGRE 517
E L + NAL +E
Sbjct: 2584 EDLRRSFNALQEEKQDLSKE 2603
Score = 51.2 bits (121), Expect = 4e-06
Identities = 88/406 (21%), Positives = 169/406 (41%), Gaps = 63/406 (15%)
Query: 108 VESSLEDASFEKA-AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEK--------- 157
++S L++ E AE R + + E+L+++ S+ E EI +++ L E+K
Sbjct: 836 LQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT 895
Query: 158 --SKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNE 215
K Q E+ +++ + L +E SL +I K +EE + K+ + E
Sbjct: 896 IEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAK----KEQVEE 951
Query: 216 NSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQ--------VLNDKE--NH 265
++++ + KQ + + + GQ+S+ Q F+ K EQ ++N KE
Sbjct: 952 DNEVSSGLKQNYDEMSPA--GQISKEELQH-EFDLLKKENEQRKRKLQAALINRKELLQR 1008
Query: 266 IKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLN 325
+ L L +KD++ +++ + EV EN + + +++ K
Sbjct: 1009 VSRLEEELANLKDES---KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT 1065
Query: 326 VSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNL------QTQQASLQSENIYFESENQK 379
+S K E E HI L E +E+ +K + +T Q L I SENQ
Sbjct: 1066 ISEK--EVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEI---SENQA 1120
Query: 380 LQQKLKIMTEFYQENEMKLYRKLTV---------EENYRIEEEEKL-----------SRV 419
+ QKL + + K TV E+++ E EEK+ ++
Sbjct: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
Query: 420 EEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDN 465
+E L+ L+ ++ + L EEL++ Y + ++++ +N
Sbjct: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKEN 1226
Score = 48.1 bits (113), Expect = 3e-05
Identities = 93/439 (21%), Positives = 195/439 (44%), Gaps = 70/439 (15%)
Query: 86 IEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDE 145
++EK K + + + +E++ +++ ++S A +EE L + ++L+ +EL +
Sbjct: 711 LDEKAKEISNLNQLIEEFK----KNADNNSSAFTALSEERDQLLSQVKELSMV-TELRAQ 765
Query: 146 ILCLEKDLKEEKSKH-------SQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
+ LE +L E + + + D L+ + S+ S+E +SK +K ++ + ++
Sbjct: 766 VKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL-SIEAKSKDVKIEVLQNELDDVQL 824
Query: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHA-EQ 257
+ SE+ ++ +++ QL +E+EV +G +++ SKV Q
Sbjct: 825 QFSEQ------------STLIRSLQSQLQNKESEVLEGA------ERVRHISSKVEELSQ 866
Query: 258 VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVN-SQWENGANLDDPLKGALK 316
L+ KE I + L K L++ + D E++ S E L++
Sbjct: 867 ALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE------- 919
Query: 317 KLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESE 376
L V +K+L+ + N LS ++ K+E E + + S + Y E
Sbjct: 920 ---EKFSLGVEIKTLKEQLN----LLSRAEEAKKEQVE-----EDNEVSSGLKQNYDEMS 967
Query: 377 NQKLQQKLKIMTEF---YQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETY 433
K ++ EF +ENE + RKL R E +++SR+EE+L+ ++ +
Sbjct: 968 PAGQISKEELQHEFDLLKKENEQRK-RKLQAALINRKELLQRVSRLEEELANLKDESKKE 1026
Query: 434 RKLAK----DLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQK 489
L++ ++EE+ E Y ++ ++ + + + +L ++ +S+ E H ++
Sbjct: 1027 IPLSETERGEVEEDKENKE--YSEKCVTSKCQEIEIYL-----KQTISEKEVELQHIRKD 1079
Query: 490 LTE---TELKFELLEKDPN 505
L E E +F+ L K N
Sbjct: 1080 LEEKLAAEEQFQALVKQMN 1098
Score = 48.1 bits (113), Expect = 3e-05
Identities = 89/416 (21%), Positives = 165/416 (39%), Gaps = 73/416 (17%)
Query: 62 SFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSL----IQKEYEGYEVESSLEDASF 117
S ++ R R+ VG Q+L +I EK +L+++ + +++E G + S ++D +
Sbjct: 2468 SLQNDRDRI-VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRG--LRSHMDDLNS 2524
Query: 118 EKAAAEEARSLEATCEKLNR------------------SNSELEDEILCLEKDLKEEKSK 159
E A + L E LN+ N ELE++ LE+ LKE +
Sbjct: 2525 ENAKLDA--ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEA 2582
Query: 160 HSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQL 219
+ + + Q L E +SLK I S+ R + AL E L
Sbjct: 2583 NEDLRRSFNALQEEKQDLSKEIESLKVSI------------SQLTRQVT---ALQEEGTL 2627
Query: 220 QTSHKQLFQQEAEVWK---------GQVSELNKQKITFEDSKVHAEQVLNDK-ENHIKTL 269
H QL +E EV + +++EL ++ + + + DK + +K L
Sbjct: 2628 GLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL 2687
Query: 270 TGHLPMMKDQAAVLEEDTTD--DDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS 327
+M+++ EE + D +E+E N KG ++ S
Sbjct: 2688 HHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKEN-----KGLTAQI---QSFGRS 2739
Query: 328 LKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIM 387
+ SL+ R+H E+D+ K + +K L A L+ + + E L +
Sbjct: 2740 MSSLQNSRDH---ANEELDELKRKYDASLKEL----AQLKEQGL-LNRERDALLSETAFS 2791
Query: 388 TEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEE 443
+EN + KL + + ++E+L + +L + Q++++ K L+ E
Sbjct: 2792 MNSTEENSLSHLEKLNQQ---LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE 2844
Score = 46.2 bits (108), Expect = 1e-04
Identities = 73/366 (19%), Positives = 158/366 (43%), Gaps = 39/366 (10%)
Query: 107 EVESSLEDASFEKAAAEEARSLEATCEKLNRSN-SELEDEILCLEKDLKEEKSKHSQQDE 165
E++ + E+ +F K + R+ EA E L++ ++E E + K +K Q
Sbjct: 565 EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIK-MKVFLEDTGQDFP 623
Query: 166 LMADISKSIQSLEDESKSLKSQ--------IAEAKIICKTFKMSEERRAIAIKDALN-EN 216
LM + S+ ++E E S + Q + +A + K+ K ++ A+ D
Sbjct: 624 LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683
Query: 217 SQLQTSHKQLFQQEAEVWKGQ-------------VSELNKQKITFE---DSKVHAEQVLN 260
+L+ Q+ + E K Q +S LN+ F+ D+ A L+
Sbjct: 684 DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743
Query: 261 DKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL-I 319
++ + + + L M+ + A +++ + E + +E+ D+ L + L I
Sbjct: 744 EERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 320 HAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQK 379
A +V ++ L+ E + + +Q SE I++LQ+Q + +SE + +
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTL-------IRSLQSQLQNKESEVLEGAERVRH 856
Query: 380 LQQKLKIMTEFYQENEMKLYR--KLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLA 437
+ K++ +++ + E+++ + +L +E+ +E ++ +EEK + TE + +
Sbjct: 857 ISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT--IEEKDQQVTEISFSMTEKM 914
Query: 438 KDLEEE 443
L EE
Sbjct: 915 VQLNEE 920
Score = 39.3 bits (90), Expect = 0.014
Identities = 116/592 (19%), Positives = 221/592 (37%), Gaps = 116/592 (19%)
Query: 110 SSLEDASFEKAAAEEARSLEATCE-KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELM- 167
+ +E+ K +E +T + +L+++ +E + + EKD + E +DEL+
Sbjct: 180 TEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQ 239
Query: 168 ----ADISKSIQS--------LEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNE 215
AD+ +Q LE+ +SL + ++ + +E+R
Sbjct: 240 LVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN---------- 289
Query: 216 NSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPM 275
Q +QL Q EAE TL +
Sbjct: 290 ----QILSQQLQQMEAE---------------------------------HNTLRNTVET 312
Query: 276 MKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGER 335
++++ +L E +ELEV + + NL + + L++ A + L+S R
Sbjct: 313 EREESKILLE------KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES----R 362
Query: 336 NHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENE 395
+ Q + + EE T HI +LQ LQS + +N KL Q +NE
Sbjct: 363 YSALEQKHKAE--MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ---------DKNE 411
Query: 396 MKLYRKLTVEENYRIEEEEKLSRVEEKLSR-ATEQLETYRKLA------KDLEEELERTV 448
+ T+++ + ++K + + L+R +Q ET + + + + E +
Sbjct: 412 QAVQSAQTIQQ-LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENI 470
Query: 449 HFYQKQVISYE-KRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNAL 507
QK+V+ E ++G A + L +L+ EN ++T E + E D
Sbjct: 471 ASLQKRVVELENEKG-----ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVS 525
Query: 508 DVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDPLGLSPVLPEGGGRGPRGPGNP 567
++S + + + + E+ + T + LS +L E + +
Sbjct: 526 EISIVDIANKRSSS--------AEESGQDVLENTFSQKHKELSVLLLE--MKEAQEEIAF 575
Query: 568 LDHQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSALPPQRED 627
L Q+ +R E + + D G +P++ K+ GQ +P L P E
Sbjct: 576 LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKM--KVFLEDTGQDFP---LMPNEES 630
Query: 628 RFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPD 679
+ E+ S E +S + D + E++S++ D L VPD
Sbjct: 631 SLPA-VEKEQASTEHQSRTSEEISLNDAGV--ELKSTKQDGDKSLS--AVPD 677
Score = 34.3 bits (77), Expect = 0.45
Identities = 82/428 (19%), Positives = 179/428 (41%), Gaps = 61/428 (14%)
Query: 104 EGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLK---EEKSKH 160
E E+E + SF EE L E+ ++ +ELE LE+ K EEK+ H
Sbjct: 322 EKMELEVAERKLSFHNLQ-EEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Query: 161 -SQQDELMADISKSIQSLEDE-SKSLKSQIAEAKIICKTFKMSE---ERRAIAIKDALN- 214
+ ++ + +L+D+ SK L+ + +A +T + E ++++ I LN
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440
Query: 215 -----ENSQLQTSHKQLFQQEAE-VWKGQVSELNKQKITFEDSK---VHAEQVLNDKENH 265
+ QTS ++ + + V + ++ L K+ + E+ K + + L + +
Sbjct: 441 LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500
Query: 266 IKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLN 325
+ L+ + +++ Q E D + +++ ++ + A + +
Sbjct: 501 NEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA--------------EESGQD 546
Query: 326 VSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK-- 383
V + + + + L E+ + +EE+ LQ ++A + + E ++++ +
Sbjct: 547 VLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI 606
Query: 384 LKIMTEFYQENEMKLYRKLTVEENY--RIEEE----EKLSRVEEKLS--------RATEQ 429
I + + E+ + + + EE+ +E+E E SR E++S ++T+Q
Sbjct: 607 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQ 666
Query: 430 -----LETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENA 484
L + + ++ELER + Q++ E H A E+NL + KE +
Sbjct: 667 DGDKSLSAVPDIGQCHQDELER----LKSQILELELNFHK---AQEIYEKNLDEKAKEIS 719
Query: 485 HNKQKLTE 492
+ Q + E
Sbjct: 720 NLNQLIEE 727
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 73.6 bits (179), Expect = 7e-13
Identities = 97/477 (20%), Positives = 204/477 (42%), Gaps = 39/477 (8%)
Query: 64 RSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEY-----EGYEVESSLEDASFE 118
+ VR+ ++++ + LS EE + + +Q+E E + ++ LE+ +
Sbjct: 1449 QQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMD 1508
Query: 119 KAA-AEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSL 177
A ++ SLEA + ++ S+ E + ++K L++ ++K Q+E + + + +IQ L
Sbjct: 1509 IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQML 1568
Query: 178 EDESKSLKSQI-----AEAKIICKTFKMSEERRAIAIKDALNENSQLQTSH--KQLFQQE 230
E L+ ++ +K + + EE R K QL+ + KQ +E
Sbjct: 1569 EQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE 1628
Query: 231 AEVWKGQVSELNKQ--KITFEDSK------VHAEQVLNDKENHIKTLTGHLPMMKDQAAV 282
+G+++ L+ Q + FE K + +L D + + L P ++ A +
Sbjct: 1629 KRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQL 1688
Query: 283 LEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHA-AKLNVSLKSLEGERNHIIIQ 341
+ + V ++ ++D L + + A L L L+ E+N I +
Sbjct: 1689 KNQLEESEFTCAAAVKARKAMEVEIED-LHLQIDDIAKAKTALEEQLSRLQREKNEIQNR 1747
Query: 342 LSEVDKTKEELTEHIKNLQTQQA-------SLQSENIYFESENQKLQQKLKIMTEFYQEN 394
L E + EL + K Q + LQ++ E Q+LQ+KL+ + ++
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL-----QS 1802
Query: 395 EMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQ 454
+++ + V+++ +E K+ +E +L Q++ LA L+E +E+ ++
Sbjct: 1803 QVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQR 1862
Query: 455 VISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSN 511
+ + + N + +R L D ++E +K E K LE D +L+ +N
Sbjct: 1863 IAAENREKEQN----KRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAAN 1915
Score = 53.1 bits (126), Expect = 9e-07
Identities = 76/375 (20%), Positives = 150/375 (40%), Gaps = 49/375 (13%)
Query: 100 QKEYEGYEVESSLEDASFEKAAAEEAR---SLEATCEKLNRSNSELEDEILCLEKDLKEE 156
QK+ + EV+ E +K E+ L +++NR + E E L KDLK
Sbjct: 1605 QKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR---LRKDLKRT 1661
Query: 157 KSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC-------KTFKMSEERRAIAI 209
K+ + +LM D K+ + E LK+Q+ E++ C K ++ E + I
Sbjct: 1662 KALLADA-QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720
Query: 210 KDALNENSQLQTSHKQLFQQEAEVW-----------------KGQVSELNKQKITFEDSK 252
D + L+ +L +++ E+ K V++ ++ D +
Sbjct: 1721 DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQ 1780
Query: 253 VHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL--------ELEVNSQWENG 304
E+ +K+ L L ++ Q LE+ D + ELE ++E
Sbjct: 1781 AQLEEANKEKQE----LQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERT 1836
Query: 305 A-----NLDDPLKGALKKLIHAAKLNVSLKSLEGERN-HIIIQLSEVDKTKEELTEHIKN 358
+L LK ++KL ++ ++ E E+N + QL + + EL
Sbjct: 1837 QVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAE 1896
Query: 359 LQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSR 418
++ L+ + E+ NQ LQ LK+ + + + + ++ +EN + E S
Sbjct: 1897 ASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSD 1956
Query: 419 VEEKLSRATEQLETY 433
V+ +L + ++++
Sbjct: 1957 VDSELEDRVDGVKSW 1971
Score = 40.4 bits (93), Expect = 0.006
Identities = 45/227 (19%), Positives = 98/227 (43%), Gaps = 11/227 (4%)
Query: 295 LEVNSQWENGANLDDPLKGALKKLIHAAK----LNVSLKSLEGERNHIIIQLSEVDKTKE 350
+EV E N D+ ++ KL A K L ++ LE + + +L++ T E
Sbjct: 1247 IEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGE 1306
Query: 351 ELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRI 410
++ + ++ + E +++ L++++++M + E +L R E N +
Sbjct: 1307 SASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVME--MEVMEARLIR--AAEINGEV 1362
Query: 411 EEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAAR 470
++++ K RA +++ +K L++E E + Q+ E+R D +
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKR---LQQEFEDKLEVEQQNKRQLERRLGDLQADSE 1419
Query: 471 TAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGRE 517
++R L L+K+ +L +T+L E + + L+ F E
Sbjct: 1420 ESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSE 1466
Score = 34.3 bits (77), Expect = 0.45
Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 20/133 (15%)
Query: 378 QKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLA 437
++LQQ+ + E Q+N+ +L R+L + E + L ++++K R T +L+
Sbjct: 1387 KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQ------ 1440
Query: 438 KDLEEELERTVHFYQKQVISYE----KRGHDNWLAARTAERNLSDLRKENAHNKQKLTET 493
+ +H +QV ++E +R D+ L+ E L++E ++ +
Sbjct: 1441 -------DTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLA 1493
Query: 494 E---LKFELLEKD 503
E LK +L EKD
Sbjct: 1494 EAFSLKQQLEEKD 1506
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 73.6 bits (179), Expect = 7e-13
Identities = 97/477 (20%), Positives = 204/477 (42%), Gaps = 39/477 (8%)
Query: 64 RSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEY-----EGYEVESSLEDASFE 118
+ VR+ ++++ + LS EE + + +Q+E E + ++ LE+ +
Sbjct: 1449 QQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMD 1508
Query: 119 KAA-AEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSL 177
A ++ SLEA + ++ S+ E + ++K L++ ++K Q+E + + + +IQ L
Sbjct: 1509 IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQML 1568
Query: 178 EDESKSLKSQI-----AEAKIICKTFKMSEERRAIAIKDALNENSQLQTSH--KQLFQQE 230
E L+ ++ +K + + EE R K QL+ + KQ +E
Sbjct: 1569 EQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE 1628
Query: 231 AEVWKGQVSELNKQ--KITFEDSK------VHAEQVLNDKENHIKTLTGHLPMMKDQAAV 282
+G+++ L+ Q + FE K + +L D + + L P ++ A +
Sbjct: 1629 KRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQL 1688
Query: 283 LEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHA-AKLNVSLKSLEGERNHIIIQ 341
+ + V ++ ++D L + + A L L L+ E+N I +
Sbjct: 1689 KNQLEESEFTCAAAVKARKAMEVEIED-LHLQIDDIAKAKTALEEQLSRLQREKNEIQNR 1747
Query: 342 LSEVDKTKEELTEHIKNLQTQQA-------SLQSENIYFESENQKLQQKLKIMTEFYQEN 394
L E + EL + K Q + LQ++ E Q+LQ+KL+ + ++
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL-----QS 1802
Query: 395 EMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQ 454
+++ + V+++ +E K+ +E +L Q++ LA L+E +E+ ++
Sbjct: 1803 QVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQR 1862
Query: 455 VISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSN 511
+ + + N + +R L D ++E +K E K LE D +L+ +N
Sbjct: 1863 IAAENREKEQN----KRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAAN 1915
Score = 51.2 bits (121), Expect = 4e-06
Identities = 78/387 (20%), Positives = 153/387 (39%), Gaps = 51/387 (13%)
Query: 100 QKEYEGYEVESSLEDASFEKAAAEEAR---SLEATCEKLNRSNSELEDEILCLEKDLKEE 156
QK+ + EV+ E +K E+ L +++NR + E E L KDLK
Sbjct: 1605 QKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR---LRKDLKRT 1661
Query: 157 KSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC-------KTFKMSEERRAIAI 209
K+ + +LM D K+ + E LK+Q+ E++ C K ++ E + I
Sbjct: 1662 KALLADA-QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720
Query: 210 KDALNENSQLQTSHKQLFQQEAEVW-----------------KGQVSELNKQKITFEDSK 252
D + L+ +L +++ E+ K V++ ++ D +
Sbjct: 1721 DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQ 1780
Query: 253 VHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL--------ELEVNSQWENG 304
E+ +K+ L L ++ Q LE+ D + ELE ++E
Sbjct: 1781 AQLEEANKEKQE----LQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERT 1836
Query: 305 A-----NLDDPLKGALKKLIHAAKLNVSLKSLEGERN-HIIIQLSEVDKTKEELTEHIKN 358
+L LK ++KL ++ ++ E E+N + QL + + EL
Sbjct: 1837 QVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAE 1896
Query: 359 LQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSR 418
++ L+ + E+ NQ LQ LK+ + + + + ++ +EN + L
Sbjct: 1897 ASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDL--INSLQD 1954
Query: 419 VEEKLSRATEQLETYRKLAKDLEEELE 445
+ K + +LE + +LE+ ++
Sbjct: 1955 MVTKYQKRKNKLEGDSDVDSELEDRVD 1981
Score = 40.4 bits (93), Expect = 0.006
Identities = 45/227 (19%), Positives = 98/227 (43%), Gaps = 11/227 (4%)
Query: 295 LEVNSQWENGANLDDPLKGALKKLIHAAK----LNVSLKSLEGERNHIIIQLSEVDKTKE 350
+EV E N D+ ++ KL A K L ++ LE + + +L++ T E
Sbjct: 1247 IEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGE 1306
Query: 351 ELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRI 410
++ + ++ + E +++ L++++++M + E +L R E N +
Sbjct: 1307 SASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVME--MEVMEARLIR--AAEINGEV 1362
Query: 411 EEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAAR 470
++++ K RA +++ +K L++E E + Q+ E+R D +
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKR---LQQEFEDKLEVEQQNKRQLERRLGDLQADSE 1419
Query: 471 TAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGRE 517
++R L L+K+ +L +T+L E + + L+ F E
Sbjct: 1420 ESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSE 1466
Score = 34.3 bits (77), Expect = 0.45
Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 20/133 (15%)
Query: 378 QKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLA 437
++LQQ+ + E Q+N+ +L R+L + E + L ++++K R T +L+
Sbjct: 1387 KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQ------ 1440
Query: 438 KDLEEELERTVHFYQKQVISYE----KRGHDNWLAARTAERNLSDLRKENAHNKQKLTET 493
+ +H +QV ++E +R D+ L+ E L++E ++ +
Sbjct: 1441 -------DTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLA 1493
Query: 494 E---LKFELLEKD 503
E LK +L EKD
Sbjct: 1494 EAFSLKQQLEEKD 1506
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 73.2 bits (178), Expect = 9e-13
Identities = 104/483 (21%), Positives = 192/483 (39%), Gaps = 45/483 (9%)
Query: 63 FRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAA 122
F ++ L +K AT+ E + L + +KE E V E +
Sbjct: 837 FFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQ 896
Query: 123 EEARSL---EATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED 179
E +L E CE L +S + LE +KE + +++E+ +++ ++LED
Sbjct: 897 SETENLMDAEERCEGLIKSK-------ILLEAKVKELTERLEEEEEMNSELVAKKRNLED 949
Query: 180 ESKSLKSQIAEAKIIC------------KTFKMSEERRAIA--IKDALNENSQLQTSHKQ 225
+ SLK I + ++ K +SEE A+ I E LQ +H+Q
Sbjct: 950 KCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQ 1009
Query: 226 L---FQQEAEVWKGQV---SELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQ 279
Q E + G + ++L +Q E S +++ D E + L G L M ++
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQES 1069
Query: 280 AAVLEEDTTD-DDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGE---- 334
LE D ++ L+ + + A +DD +L+ +L ++ LE E
Sbjct: 1070 IMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE 1129
Query: 335 ---RNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFY 391
R I Q S++ + EE++E ++ ++ N E+E QK+++ L+ T +
Sbjct: 1130 HTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQH 1189
Query: 392 QENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLE-TYRKLAKDLE------EEL 444
+ L +K E+ + L RV++KL + +L+ +A ++E +
Sbjct: 1190 EATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNI 1249
Query: 445 ERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDP 504
ERT + Q + + + L+ +N ++ E E L K
Sbjct: 1250 ERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSK 1309
Query: 505 NAL 507
AL
Sbjct: 1310 QAL 1312
Score = 69.7 bits (169), Expect = 1e-11
Identities = 108/441 (24%), Positives = 190/441 (43%), Gaps = 47/441 (10%)
Query: 99 IQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKS 158
IQ+ E E + L E A E + + C L ++ L+ E+ L +DL+ +
Sbjct: 1384 IQRTEELEEAKKKLAQRLQE--AEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441
Query: 159 KHSQQDELMADISKSI----QSLEDESKSLKSQIAEAKIIC-KTFKMSEERRAIA--IKD 211
+ D+ + K + Q L++ L++ E++ + + FKM + ++
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 212 ALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHI----- 266
EN LQ L +Q AE K + E K K E K + L + E +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKN-LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEES 1560
Query: 267 KTLTGHLPMMKDQAAVLEEDTTDDDNLE-LEVNSQWENGANLDDPLKGALKKLIHAAKLN 325
K L L + + ++ + + D+ +E L+ NSQ A L L ++ A +L
Sbjct: 1561 KILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEA-LQSVLDAEIRSRNDALRLK 1619
Query: 326 VSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFES---ENQKLQQ 382
K +EG+ N + IQL + ++ E K+L+T Q L+ ++ + N+ L++
Sbjct: 1620 ---KKMEGDLNEMEIQLGH---SNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKE 1673
Query: 383 KLKIMTE-----FYQENEMKLYRKLTVEENYRIEEEEKL---SRVEEKLSRATEQLETYR 434
+L I+ + EMK+ + T E R+ E+E L RV+ S+ T + T +
Sbjct: 1674 QLAIVERRNGLLLEELEEMKVALEQT-ERTRRLSEQELLDASDRVQLLHSQNTSLINTKK 1732
Query: 435 KLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKE---NAH---NKQ 488
KL D+ + + Q+ + EK AA AE +L+KE +AH K+
Sbjct: 1733 KLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAE----ELKKEQDTSAHLERMKK 1788
Query: 489 KLTET--ELKFELLEKDPNAL 507
L +T +L+ L E + AL
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLAL 1809
Score = 63.9 bits (154), Expect = 5e-10
Identities = 87/396 (21%), Positives = 176/396 (44%), Gaps = 54/396 (13%)
Query: 86 IEEKCKLLEK------FSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSN 139
+E+KC L++ +L + E E + E+ +++ S EE +LE KL +
Sbjct: 947 LEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS------EEMTALEENISKLTKEK 1000
Query: 140 SELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLE---DESKSLKSQIAEAKIICK 196
L++ DL+ E+ K + ++ A + + LE ++ K L++ + AK +
Sbjct: 1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE 1060
Query: 197 -TFKMSEERRAIAIKDALNENSQLQTSHK----QLFQQEAEVWKGQVSELNKQKITFE-- 249
KMS+E +I D N+ Q++ K +L Q +A++ QV L QK E
Sbjct: 1061 GDLKMSQE----SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116
Query: 250 ------DSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE- 302
+ ++ AE L K I+ L ++ + E+ + + ++E+N + E
Sbjct: 1117 ARIEELEEEIEAEHTLRAK---IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173
Query: 303 ---------NGANLDDPLKGAL---KKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKE 350
A L A K+ A+L + +L+ + + + SE+ +
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
Query: 351 ELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTV--EENY 408
++ +I+ L +++++ E + +++ K + T+ + M+ R T E ++
Sbjct: 1234 DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSH 1293
Query: 409 RIEEEEKL-SRVEEKLSRATEQLETYRKLAKDLEEE 443
R+EE+E L S++ + T+QLE +L + +EEE
Sbjct: 1294 RVEEKESLISQLTKSKQALTQQLE---ELKRQMEEE 1326
Score = 53.9 bits (128), Expect = 6e-07
Identities = 81/371 (21%), Positives = 167/371 (45%), Gaps = 62/371 (16%)
Query: 107 EVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQ--- 163
EVE SLE EE++ L E L++ SEL+ +++ EKD + E+ K + Q
Sbjct: 1550 EVEGSLEH--------EESKILRVQLE-LSQVKSELDRKVI--EKDEEIEQLKRNSQRAA 1598
Query: 164 DELMADISKSIQSLEDE---SKSLKSQIAEAKIIC--KTFKMSEERRAIAIKDALNENSQ 218
+ L + + I+S D K ++ + E +I +M+E ++ + ++SQ
Sbjct: 1599 EALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQ 1658
Query: 219 LQT-----SHKQLFQQEAEVWKGQ---VSELNKQKITFEDSKVH---AEQVLNDKENHIK 267
L S++ L +Q A V + + EL + K+ E ++ +EQ L D + ++
Sbjct: 1659 LHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQ 1718
Query: 268 TLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS 327
L + + LE D + EV + + N ++ K K + AA +
Sbjct: 1719 LLHSQNTSLINTKKKLEADIAQ---CQAEVENSIQESRNAEEKAK---KAITDAAMMAEE 1772
Query: 328 LKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIM 387
LK + H+ ++ K+ L + +K+LQ + ++E + + +++Q+ +
Sbjct: 1773 LKKEQDTSAHL-------ERMKKNLEQTVKDLQHRLD--EAEQLALKGGKKQIQKLENRV 1823
Query: 388 TEFYQENEMKL--------------YRKLTVEENYRIEEEEK-LSRVEEKLSRATEQLET 432
E ENE+ + Y + E Y+ EE+ K + R+++ + + ++++
Sbjct: 1824 REL--ENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKS 1881
Query: 433 YRKLAKDLEEE 443
Y++ A++ EE+
Sbjct: 1882 YKRQAEEAEEQ 1892
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 72.4 bits (176), Expect = 2e-12
Identities = 94/436 (21%), Positives = 186/436 (42%), Gaps = 40/436 (9%)
Query: 85 LIEEKCKLLEKFSLIQKEY-EGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELE 143
L ++ +L +K ++E+ E +V + + K + E+ + E+L +
Sbjct: 489 LARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAIL 548
Query: 144 DEILCLEKDLKEEKSKHSQQD-ELMADISKSIQSLEDESKSLKSQI-AEAKIICKTFKMS 201
E +DL++E + + EL + + KS+Q +++SK L + AE K +
Sbjct: 549 TESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM 608
Query: 202 EERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQK--ITFEDSKV----HA 255
E+ ++ ++ L T Q+ +Q+ + ++ E +Q+ +D ++ H
Sbjct: 609 VEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHI 668
Query: 256 EQV-------LNDKENHIKTLTGHLPMMKDQAAVLEE------DTTDDDNLELEVNSQWE 302
E++ L+ K+ +++L+ L + LEE D TD ELE E
Sbjct: 669 EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD-E 727
Query: 303 NGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ 362
+ + +K+ H + + K+L+ + N + + L E DK +E H++NL+
Sbjct: 728 QKNHHQQQVDSIIKE--HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
Query: 363 ----QASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSR 418
+ LQ + + Q Q T+ Y+E +L +KL E RI ++++
Sbjct: 786 IKRSEGELQQASAKLDVF-QSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAE 844
Query: 419 VEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSD 478
VE + +L+ ++ +DL ++LE+ +++V S + E L D
Sbjct: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS----------LTQVYESKLED 894
Query: 479 LRKENAHNKQKLTETE 494
KE KQ L E E
Sbjct: 895 GNKEQEQTKQILVEKE 910
Score = 66.2 bits (160), Expect = 1e-10
Identities = 99/485 (20%), Positives = 204/485 (42%), Gaps = 71/485 (14%)
Query: 77 KLGATLSGLIEEKCKLLEKFS-----LIQKEYEGYEVESSLEDASFEKAAAEE------- 124
+L A L L EE+ L F L +KE + +++ +E EK A ++
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 125 -ARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKS 183
A E+ +L + SE + + ++++LKE+K + S + + D++ +Q+ S S
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN----SIS 1388
Query: 184 LKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQ--QEAEVWKGQVSEL 241
L + A + K + +E + + + + ++ T K+ ++ + W + SE
Sbjct: 1389 LSEKEAAISSLRKQY---DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
Query: 242 NKQ---KITFEDSKVHAEQV--------LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDD 290
K+ + T + V Q+ +K+ I L L + L+ + DD
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 291 --------DNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERN----HI 338
NLE E+ SQ L+D + +K I LN LK+ +++ +
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHIT---QKTIEIESLNEVLKNYNQQKDIEHKEL 1562
Query: 339 IIQLSEVDKTKEELTEHIKN------------------LQTQQASLQSENIYFESENQKL 380
+ +L + EE +K L+T++ L+ N+ +S+ ++L
Sbjct: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEEL 1622
Query: 381 QQKLKIMTEFYQENEMKLYR-KLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKD 439
+ + E+ KL K E+ +++ LS++EEK + + E++
Sbjct: 1623 KA---LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT 1679
Query: 440 LEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTET-ELKFE 498
+E ER VH ++++ S E + + R+A+ + +E A ++ + +T E K
Sbjct: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739
Query: 499 LLEKD 503
+L+++
Sbjct: 1740 VLQRN 1744
Score = 63.9 bits (154), Expect = 5e-10
Identities = 93/447 (20%), Positives = 203/447 (45%), Gaps = 52/447 (11%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE 133
REQK + + EE K L ++ + E + + EK + EE SL+ +
Sbjct: 402 REQKEKSERAAF-EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQ---Q 457
Query: 134 KLNRSNSEL--------EDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLK 185
+L+R E+ E++I L+K ++E ++ Q+ ++K +Q+ E E + +
Sbjct: 458 ELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQE------LTKKLQTREREFQE-Q 510
Query: 186 SQIAEAKIICKTFKMSEERR---AIAIKDA-LNENSQLQTSHKQL--FQQEAEVWKGQVS 239
++A K + K+S+E+ ++A+++ L + + L S +L QQEAE ++ ++
Sbjct: 511 MKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRIL 570
Query: 240 ELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQ-----AAVLEEDTTDDDNLE 294
EL E+ L + +N K L HL K++ ++E+ T+ ++L+
Sbjct: 571 ELESS----------LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
Query: 295 LEVNSQW-ENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELT 353
+ ++ W E L + ++KL K ++L ++ II + +++ E+
Sbjct: 621 HQQDALWTEKLQVLKQQYQTEMEKL--REKCEQEKETLLKDKE--IIFQAHIEEMNEKTL 676
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
E + QT+ SL SE KL+++L ++ + + + +L K+ ++N+ ++
Sbjct: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
Query: 414 EKLSRVEEKLSRATE-----QLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLA 468
+ + + E + TE Q+ L K+ ++ L+ H + + + + + L
Sbjct: 737 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE--HQAHVENLEADIKRSEGELQ 794
Query: 469 ARTAERNLSDLRKENAHNKQKLTETEL 495
+A+ ++ + H + K E +L
Sbjct: 795 QASAKLDVFQSYQSATHEQTKAYEEQL 821
Score = 61.6 bits (148), Expect = 3e-09
Identities = 102/445 (22%), Positives = 187/445 (42%), Gaps = 58/445 (13%)
Query: 89 KCKLLEKFSLIQKEYEGYEVESSLEDASF-----EKAAAEEARSLEATCEKLNRSNSELE 143
K KLL++ + ++KE E +E S ++ F E A A A +A ++E
Sbjct: 971 KKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE 1030
Query: 144 DEILCLEKDLKE-----EKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
++L + EK + Q +EL +Q E E LK +I C+
Sbjct: 1031 SLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI--LLFGCEKE 1088
Query: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQV 258
+M++E + ++ + +++ L +QL Q+ A V N K H E++
Sbjct: 1089 EMNKEITWLK-EEGVKQDTTLNELQEQLKQKSAHV--------NSLAQDETKLKAHLEKL 1139
Query: 259 LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL 318
D +K T +++Q L+ +D E+ S+ + LK + +K
Sbjct: 1140 EVDLNKSLKENT----FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK- 1194
Query: 319 IHAAKLNVSLKSLEGER--NHIIIQLSEVDKTKEEL----TEHIKNLQTQQA-SLQSENI 371
+ ++ KSLE ++ + IQL K E L T + N+ + + ++ S
Sbjct: 1195 ---SNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS 1251
Query: 372 YFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLE 431
+ + K+++ L I T E E +L R+LT E+N + +AT QLE
Sbjct: 1252 HCQHRTTKVKEALLIKTCTVSELEAQL-RQLTEEQN----------TLNISFQQATHQLE 1300
Query: 432 TYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHN----- 486
K ++ ++E V +K+ + +K G + AA E ++ L+KE + N
Sbjct: 1301 EKENQIKSMKADIESLV--TEKEAL--QKEGGNQQQAASEKESCITQLKKELSENINAVT 1356
Query: 487 --KQKLTETELKFELLEKDPNALDV 509
K++L E +++ L K L+V
Sbjct: 1357 LMKEELKEKKVEISSLSKQLTDLNV 1381
Score = 56.2 bits (134), Expect = 1e-07
Identities = 99/474 (20%), Positives = 211/474 (44%), Gaps = 79/474 (16%)
Query: 80 ATLSGLIEEKCKL---LEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLN 136
A ++ L +++ KL LEK + ++ SL++ +F + E+ L+ E+
Sbjct: 1120 AHVNSLAQDETKLKAHLEKLEV--------DLNKSLKENTFLQ---EQLVELKMLAEEDK 1168
Query: 137 RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDES---KSLKSQIAEAKI 193
R SEL ++ +++ + KS H KS +SLED+S K L ++A
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSH----------EKSNKSLEDKSLEFKKLSEELAIQLD 1218
Query: 194 IC--KTFKMSEERRAIAIKDALNENSQL-----QTSHKQLFQQEAEVWK--------GQV 238
IC KT + E + I + ++ + + H+ +EA + K Q+
Sbjct: 1219 ICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQL 1278
Query: 239 SELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEED-------TTDDD 291
+L +++ T S A L +KEN IK++ + + + L+++ ++ +
Sbjct: 1279 RQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
Query: 292 NLELEVNSQWENGANLDDPLKGALK-KLIHAAKLNVSLKSLE---------GERNHIIIQ 341
+ ++ + N +K LK K + + L+ L L E+ I
Sbjct: 1339 SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
Query: 342 L-SEVDKTKEELTEHIKNLQTQQASLQSENI-----YFESENQKLQQKLKIMTEFYQE-- 393
L + D+ K EL + +++L + +L E I + N+ + K K + F Q
Sbjct: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
Query: 394 --NEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFY 451
E+++ +L +E Y E++E+++ ++E+L + ++ + + +D + ++E+
Sbjct: 1459 TVKELQIQLELKSKEAY--EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Query: 452 QKQVISYEKR--GHDNWLAARTAE-RNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ++ S R ++ + +T E +L+++ K +N+QK E + EL++K
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKN--YNQQKDIEHK---ELVQK 1565
Score = 46.2 bits (108), Expect = 1e-04
Identities = 105/511 (20%), Positives = 204/511 (39%), Gaps = 76/511 (14%)
Query: 64 RSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAE 123
+ + S++ EQ T S L E KL E+ E E + +E L+ S E + +E
Sbjct: 1653 KQLLSQMEEKEEQYKKGTESHLSELNTKLQER------EREVHILEEKLK--SVESSQSE 1704
Query: 124 EARSLEATCEKLNRSNSELEDEILCLEKDLKEEKS----KHSQQDELMADISKSIQSLED 179
+ + E D C++K +E+ S +++++L+ + + +
Sbjct: 1705 TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764
Query: 180 ESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVS 239
++ Q E I + + + I E + + + Q E G+ +
Sbjct: 1765 SHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNN 1824
Query: 240 ELNKQKI--TFED-SKVHAEQVLNDK--ENHIKTLTGHLPMMKDQAAV-LEEDTTDDDNL 293
KQ + F+D K E+ L + E IK L L K+ V +EE T+ + L
Sbjct: 1825 IQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL 1884
Query: 294 ELEVNSQWENGAN--LDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEE 351
+ N L++ + K + KL L ++E + N + +L+ ++ K++
Sbjct: 1885 QALQQMDGRNKPTELLEENTEEKSKSHLVQPKL---LSNMEAQHNDLEFKLAGAEREKQK 1941
Query: 352 LTEHIKNLQTQQASLQSEN-----IYFESENQKLQQKLK----------------IMTEF 390
L + I LQ L+ E+ I + +Q+ ++K+K +M EF
Sbjct: 1942 LGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREF 2001
Query: 391 -----YQENEMKLYRKLTVEENYRIEEEEKLSRVEEK---LSRATEQLETYRKLAK---- 438
+E E+++ K T+ + +E E S EE L + E+ + ++ AK
Sbjct: 2002 NTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 439 --------------DLEEELERTVHFYQKQVISYEKRGHDN----WLAARTAERN--LSD 478
DL+ +LE YQ+++ E G+DN L + A++ +SD
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISD 2121
Query: 479 LRKENAHNKQKLTETELKFELLEKDPNALDV 509
+ + ++++ E + + EK+ A V
Sbjct: 2122 SKLKEQEFREQIHNLEDRLKKYEKNVYATTV 2152
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 71.6 bits (174), Expect = 3e-12
Identities = 103/477 (21%), Positives = 202/477 (42%), Gaps = 50/477 (10%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDAS-----FEKAAAEEARSLEA 130
Q+L A +S + +L EK S +Q E + V + LE+A F K AA L+
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDN--VSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 131 TCEKLN---RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQ 187
T E L R L I LE++ + + +++E ++ K + +L+ + K +
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379
Query: 188 IAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVS-ELNKQKI 246
+ + T + EE + +KDA + +L+ K L + E K ++ EL+ +
Sbjct: 1380 VDDD---LGTIESLEEAKKKLLKDAEALSQRLE--EKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 247 TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
+ H QV ++ E K L K +A E+ D E E + +
Sbjct: 1435 DLD----HQRQVASNLEKKQKKFDQLLAEEKSISARYAEER---DRAEAEAREKETKALS 1487
Query: 307 LDDPLKGALKKLIHAAKLNVSLKS----LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ 362
L L+ AL+ + N L++ L ++ + + E++K+K L + ++ ++TQ
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 363 QASLQSENIYFESENQKLQQKLKIMTEFYQ----------ENEMKLYRKLTVEENYRIEE 412
L+ E E +L+ ++ M ++ E + +L K E +E+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 413 EEKLSRV----EEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKR------G 462
E K + ++K+ + LE + A +E+ + + Q Q+ Y++
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 463 HDNWLA-ARTAERNLSDLRKENAHNKQKLTETE--LKFELLEKDPNALDVSNTAFGR 516
D A ++ +E+ L L E +++L +E + E+D A +++N+A G+
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Score = 68.2 bits (165), Expect = 3e-11
Identities = 105/474 (22%), Positives = 210/474 (44%), Gaps = 54/474 (11%)
Query: 107 EVESSLEDASFEKAAAEE------ARSLEATCEKLNRSN--SELEDEILCLEKDLKEEKS 158
E+++ +++ + A EE AR + T K N EL+ +I L++D + EK+
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 159 KHSQQDELMADISKSIQSLEDESK-SLKSQIAEAKIICKTFKMSEERRAIAIKDALNENS 217
++ ++ D+S+ +++L+ E + +L + A+ ++ K + E + ++ N +
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192
Query: 218 QLQ-------TSHKQLFQQ--EAEVWKGQVSELNKQKITFEDSKVHAE-----QVLNDKE 263
Q+Q T+ ++L +Q +A+ +K + E NKQ + ++ ++ E QV + E
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANL-EKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVN---SQWENGA-NLDDPLKGALKKLI 319
+ K L Q L ++ D L +E+ S+ +N N+ L+ A KK I
Sbjct: 1252 HKRKKLDA-------QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 320 HAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQK 379
AK SL+S + + L E + K L+ I+ L+ ++ SLQ + E +
Sbjct: 1305 KFAKDAASLESQLQDTQEL---LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 380 LQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKD 439
L++++ + + + K+ L E+ +++ L E R E+ Y KL K
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 440 ---LEEEL-ERTVHF-YQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETE 494
L++EL + TV +Q+QV S ++ + E+++S E +
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA----- 1476
Query: 495 LKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDPLG 548
E EK+ AL ++ E A +++ + RA + +D +G
Sbjct: 1477 ---EAREKETKALSLARAL---EEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524
Score = 65.1 bits (157), Expect = 2e-10
Identities = 99/484 (20%), Positives = 197/484 (40%), Gaps = 66/484 (13%)
Query: 59 LWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVE-SSLEDASF 117
L+ +R+RL ++Q+L L L + E+ ++Q E + + LE+
Sbjct: 902 LFAEAEEMRARL-AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 118 EKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSL 177
E+ A + LE + ++E+EIL LE ++ SK ++ +LM
Sbjct: 961 EEEGARQKLQLEKVTAEAKIK--KMEEEILLLE----DQNSKFIKEKKLM---------- 1004
Query: 178 EDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQL----------- 226
ED SQ+AE + K ++ + I D + + + ++L
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 227 --FQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLE 284
Q + + Q+ EL Q E+ A +D+ H + ++ Q A L+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124
Query: 285 EDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSL------------KSLE 332
ED + + Q + + + LK L+ + L K+LE
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 333 GERNHIIIQLSEVDK----TKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMT 388
E + Q+ ++ + EEL+E ++ + +A+L+ E++N++L ++K++
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 389 EFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYR---- 434
+ E+E K L+ K++ + R+E EK S+++ +L + LE
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 435 KLAKD---LEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLT 491
K AKD LE +L+ T Q++ + +K + + E+N ++E +K
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEE--TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL 1362
Query: 492 ETEL 495
E ++
Sbjct: 1363 EKQV 1366
Score = 63.9 bits (154), Expect = 5e-10
Identities = 94/414 (22%), Positives = 179/414 (43%), Gaps = 55/414 (13%)
Query: 60 WRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESS--LEDASF 117
WR F V+ L V R+++ L EE K+ EK + ++ E E E + LE+ +
Sbjct: 835 WRVFTKVKPLLQVTRQEE---ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI 891
Query: 118 EKAAAEEARSLEATCE----KLNRSNSELEDEILCLEKDLKEEKSKH----SQQDELMAD 169
+ L A E +L ELE+ + LE ++EE+ ++ +++ ++ A
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 170 ISKSIQSLEDESKS-----LKSQIAEAKI--ICKTFKMSEERRAIAIKDALNENSQLQTS 222
I + L++E + L+ AEAKI + + + E++ + IK+ ++
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 223 HKQLFQQEAEVWKGQVSELNKQKITFEDSKVH---AEQVLNDKENHIKTLTGHLPMMKDQ 279
QL ++E E K NKQ++ D + E+ + E + L G ++DQ
Sbjct: 1012 SSQLAEEE-EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 280 AAVLEEDTTDDDNLELEVNSQWENGA---------NLDDPLKGALKKLIHAAKLNVSLKS 330
A L+ D+ L+L + GA + ++ LK + A+L +S
Sbjct: 1071 IAELQAQ-IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129
Query: 331 LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEF 390
+ RN + +K K +L+E ++ L+T+ + + + Q+L+ K
Sbjct: 1130 EKASRN-------KAEKQKRDLSEELEALKTE----LEDTLDTTAAQQELRTK------- 1171
Query: 391 YQENEMKLYRKLTVEE--NYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEE 442
+E E+ +K EE N+ + ++ R L +EQLE ++ +LE+
Sbjct: 1172 -REQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Score = 63.9 bits (154), Expect = 5e-10
Identities = 92/408 (22%), Positives = 177/408 (43%), Gaps = 59/408 (14%)
Query: 123 EEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESK 182
E+ +E E++ R + +L +E L + L+ E ++ +E+ A ++ Q LE+
Sbjct: 866 EKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 925
Query: 183 SLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSELN 242
L+S++ E EER I NE ++Q +H Q +++ + +G +L
Sbjct: 926 DLESRVEE----------EEERNQI----LQNEKKKMQ-AHIQDLEEQLDEEEGARQKLQ 970
Query: 243 KQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE 302
+K+T E E+ + E+ +M+D+ A +++ E
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE----------E 1020
Query: 303 NGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ 362
NL K K+ + + L LK E R E++K K +L +LQ Q
Sbjct: 1021 KAKNL---AKIRNKQEVMISDLEERLKKEEKTR-------QELEKAKRKLDGETTDLQDQ 1070
Query: 363 QASLQSE----NIYFESENQKLQQKLKIMTE--FYQENEMKLYRKL--TVEENYRIEEEE 414
A LQ++ + + ++LQ L + ++ N +K+ R+L + E E E
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 415 KLSR--VEEKLSRATEQLETYRKLAKDLEEELERT-----VHFYQKQVISYEKRGHDNWL 467
K SR E++ +E+LE L +LE+ L+ T + ++Q ++ K+ +
Sbjct: 1131 KASRNKAEKQKRDLSEELEA---LKTELEDTLDTTAAQQELRTKREQEVAELKKALEE-- 1185
Query: 468 AARTAERNLSDLRKENAHNKQKLT---ETELKFEL-LEKDPNALDVSN 511
+ E + D+R+ +A ++L+ E +F+ LEK+ L+ N
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233
Score = 58.5 bits (140), Expect = 2e-08
Identities = 97/485 (20%), Positives = 199/485 (41%), Gaps = 50/485 (10%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK-----EYEGYEVESSLEDASFEKAAAEEAR-- 126
+ ++L A + L+ K + + ++K E + E+ + LE+ E A E+A+
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 127 ------SLEATCEK-LNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED 179
+++A E+ L + + E++ L K ++E +++ + + A S + +E
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI 1624
Query: 180 ESKSLKSQIAEA-KIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWK--- 235
+ K L++QI A K + K + +A +KD E + + S ++F Q E K
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLRKLQA-QMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Query: 236 ---GQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDN 292
++ +L ++ + E ++ HAEQ ++ + I + D+ LE
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQ--- 1740
Query: 293 LELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEEL 352
LE E+ + N L+D + K + LN L + ER+ + D +++L
Sbjct: 1741 LEEELEEEQSNMELLNDRFR---KTTLQVDTLNAELAA---ERS----AAQKSDNARQQL 1790
Query: 353 TEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEE 412
K L+ + L+ ++ K K + +L +L E R
Sbjct: 1791 ERQNKELKAKLQELEGA----------VKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840
Query: 413 EEKLSRVEEKLSRATEQLETYRKLAKDLEEELERT---VHFYQKQVISYEKRGHDNWLAA 469
+ + R E+KL Q+E R+ A +E++E+ + ++Q+ E+ +
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQR 529
R +R L D + N +++ + LK L P + S + + H L
Sbjct: 1901 RKLQRELDDATEANEGLSREV--STLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDD 1958
Query: 530 SSETR 534
+E++
Sbjct: 1959 DTESK 1963
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 71.6 bits (174), Expect = 3e-12
Identities = 104/459 (22%), Positives = 208/459 (45%), Gaps = 68/459 (14%)
Query: 55 VLLFLW--RSFRSVRS----RLY-----VGREQKLGATLSGLIEEKCKLLEKFSLIQKEY 103
++L W R+F +V++ RL+ + + ++G ++GL EE C L+K +L + E+
Sbjct: 823 LILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEE-CAQLQK-ALEKSEF 880
Query: 104 EGYEVESSLEDASFEK--------AAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKE 155
+ E+++ + EK A E ++E CE L +S +LE + KE
Sbjct: 881 QREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARV-------KE 933
Query: 156 EKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNE 215
+ +++E+ ++++ + LEDE LK +I + + + K +E+R
Sbjct: 934 LSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETM--LVKSEKEKRT--------- 982
Query: 216 NSQLQTSHK-QLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLP 274
T HK + +E E +S+LN+ +++ L+ +E + +L+
Sbjct: 983 -----TEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLS---- 1033
Query: 275 MMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLN-VSLKSLEG 333
+A + E D ELE + E A ++ + L KL KLN S+++LE
Sbjct: 1034 ----KANLKLEQQVD----ELEGALEQERKARMN--CERELHKLEGNLKLNRESMENLES 1083
Query: 334 ERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKI--MTEFY 391
+ H+ +L + + ++ ++N + A LQ +++ + L++KL+ T
Sbjct: 1084 SQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAK 1143
Query: 392 QENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFY 451
E E + + N R+EE S + ++++ +Q ++KL +D+E E T+HF
Sbjct: 1144 MERERADLTQDLADLNERLEEVGGSSLAQLEITK--KQETKFQKLHRDME---EATLHF- 1197
Query: 452 QKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKL 490
+ S +KR D+ NL ++++ +K L
Sbjct: 1198 ETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDL 1236
Score = 56.2 bits (134), Expect = 1e-07
Identities = 91/461 (19%), Positives = 185/461 (40%), Gaps = 75/461 (16%)
Query: 77 KLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAA-AEEARSLEATCEKL 135
K+ + L +K KL + + E E E+ + S EK+ + L EK
Sbjct: 1277 KVTQLANDLAAQKTKLWSESGEFLRRLE--EKEALINQLSREKSNFTRQIEDLRGQLEKE 1334
Query: 136 NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSI--------------------- 174
+S S L + ++D + ++ ++ E+ A++ +++
Sbjct: 1335 TKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQR 1394
Query: 175 -QSLEDESKSLKSQI---AEAKIICKTFKMSEERRA----IAIKDALNENSQLQTSHKQL 226
+ LED K L ++ AEA + S ER + + DAL++ +++++ +L
Sbjct: 1395 TEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARL 1454
Query: 227 FQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEED 286
Q++ + K K + ++ +L+ + ++ L+ L +K+ EE
Sbjct: 1455 DQKQLQSGKALADWKQKHE--------ESQALLDASQKEVQALSTELLKLKN---TYEES 1503
Query: 287 TTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVD 346
+ L E + E +NL + ++ K L K+ K +E E+ + + L E +
Sbjct: 1504 IVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVK---KLIEEEKTEVQVTLEETE 1560
Query: 347 KTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEE 406
E +S+ ++F+ E + E E E KL K E
Sbjct: 1561 GALERN--------------ESKILHFQLE----------LLEAKAELERKLSEKDEEIE 1596
Query: 407 NYRIEEEEKLSRVEEKL-SRATEQLETYRKLAKDLEE---ELERTVHFYQKQVISYEKRG 462
N+R +++ + ++ L S A ++E R L K +EE E+E + +QV K
Sbjct: 1597 NFRRKQQCTIDSLQSSLDSEAKSRIEVTR-LKKKMEEDLNEMELQLSCANRQVSEATKSL 1655
Query: 463 HDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKD 503
+ + + L D + N+ K+++ E + LL+ +
Sbjct: 1656 GQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSE 1696
Score = 55.5 bits (132), Expect = 2e-07
Identities = 89/419 (21%), Positives = 180/419 (42%), Gaps = 66/419 (15%)
Query: 85 LIEEKCKLLEKFS-LIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELE 143
L E L E+ S L + EG + + +E +K EE ++ T E+ + E
Sbjct: 1510 LRRENKNLQEEISNLTNQVREGTKNLTEMEKV--KKLIEEEKTEVQVTLEETEGALERNE 1567
Query: 144 DEILCLEKDLKEEKS----KHSQQDELMADISKSIQ--------SLEDESKS------LK 185
+IL + +L E K+ K S++DE + + + Q SL+ E+KS LK
Sbjct: 1568 SKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLK 1627
Query: 186 SQIAE------AKIICKTFKMSEERRA-----IAIKDA---LNENSQLQTSHKQ---LFQ 228
++ E ++ C ++SE ++ I IKD L++++QL + K+ + +
Sbjct: 1628 KKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAE 1687
Query: 229 QEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTT 288
+ + + ++ +L + E + +E+ L + I + Q LE D
Sbjct: 1688 RRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVA 1747
Query: 289 DDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKT 348
EV + +N + A K I AA L+ LK + H+ ++T
Sbjct: 1748 RMQKEAEEVVQECQNAE------EKAKKAAIEAANLSEELKKKQDTIAHL-------ERT 1794
Query: 349 KEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEEN- 407
+E + + I +LQ + A ++E + +++Q+ + E E E ++ R +
Sbjct: 1795 RENMEQTITDLQKRLA--EAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGA 1852
Query: 408 -----------YRIEEEEK-LSRVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQ 454
Y+ EE++K LSR++ ++ + +++ Y++ + E + + + Y+KQ
Sbjct: 1853 RRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQ 1911
Score = 45.4 bits (106), Expect = 2e-04
Identities = 78/367 (21%), Positives = 142/367 (38%), Gaps = 63/367 (17%)
Query: 168 ADISKSIQSLEDESKSL-----KSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTS 222
+++ + + L++E L KS+ ++ K +++E+ + + QLQ
Sbjct: 855 SEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLIL--------QLQAE 906
Query: 223 HKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAV 282
+ L E Q L K KI E + + ++E LT ++D+
Sbjct: 907 QETLANVEE-----QCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFE 961
Query: 283 LEEDTTDDDNL----ELEVNSQWENGANLDDP---LKGALKKLIHAAKL-----NVSLKS 330
L+++ D + + E E + NL + L + KL AAK+ +L
Sbjct: 962 LKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD 1021
Query: 331 LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEF 390
L E +LS + K +L + + L+ + + E E KL+ LK+ E
Sbjct: 1022 LHMEEE----KLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRES 1077
Query: 391 YQENEMKLYRKLTVEENYRIEEEEKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHF 450
EN R L E+L + E +LS+ ++E K L +L++TV
Sbjct: 1078 -MENLESSQRHLA----------EELRKKELELSQMNSKVEN----EKGLVAQLQKTVKE 1122
Query: 451 YQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTET--------------ELK 496
Q Q+ +++ ER +DL ++ A ++L E E K
Sbjct: 1123 LQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETK 1182
Query: 497 FELLEKD 503
F+ L +D
Sbjct: 1183 FQKLHRD 1189
Score = 40.0 bits (92), Expect = 0.008
Identities = 54/211 (25%), Positives = 92/211 (43%), Gaps = 36/211 (17%)
Query: 83 SGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEA------RSLEATCEKLN 136
+ L+ +K KL + +QKE E E + +KAA E A + + T L
Sbjct: 1733 TSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLE 1792
Query: 137 RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI-------A 189
R+ +E I L+K L E ++Q LM K IQ LE + L+ ++ A
Sbjct: 1793 RTRENMEQTITDLQKRLAE-----AEQMALMGS-RKQIQKLESRVRELEGELEGEIRRSA 1846
Query: 190 EAK---------IICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQ--- 237
EA+ I T++ E+++ ++ + QL+ Q ++Q+ EV + Q
Sbjct: 1847 EAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKV---QNYKQQVEVAETQANQ 1903
Query: 238 -VSELNKQKITFEDSKVHAEQVLNDKENHIK 267
+S+ KQ+ + K AE V + N +K
Sbjct: 1904 YLSKYKKQQHELNEVKERAE-VAESQVNKLK 1933
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,299,234
Number of Sequences: 37866
Number of extensions: 2168113
Number of successful extensions: 18971
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 292
Number of HSP's successfully gapped in prelim test: 1313
Number of HSP's that attempted gapping in prelim test: 10233
Number of HSP's gapped (non-prelim): 5862
length of query: 777
length of database: 18,247,518
effective HSP length: 110
effective length of query: 667
effective length of database: 14,082,258
effective search space: 9392866086
effective search space used: 9392866086
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.