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Search of human proteins with 56121815
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56121815 ADAM metallopeptidase with thrombospondin type 1
motif, 10 preproprotein [Homo sapiens]
(1103 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 2350 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 1447 0.0
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 698 0.0
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 684 0.0
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 681 0.0
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 641 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 596 e-170
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 580 e-165
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 541 e-153
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 496 e-140
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 494 e-139
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 474 e-133
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 473 e-133
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 468 e-131
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 433 e-121
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 431 e-120
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 402 e-111
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 399 e-111
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 399 e-111
gi|145309328 papilin [Homo sapiens] 351 2e-96
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 346 8e-95
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 346 8e-95
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 325 2e-88
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 292 1e-78
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 285 1e-76
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 284 4e-76
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 266 8e-71
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 261 2e-69
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 261 2e-69
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 222 2e-57
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 2350 bits (6091), Expect = 0.0
Identities = 1103/1103 (100%), Positives = 1103/1103 (100%)
Query: 1 MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPP 60
MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPP
Sbjct: 1 MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPP 60
Query: 61 PRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARP 120
PRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARP
Sbjct: 61 PRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARP 120
Query: 121 HCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVY 180
HCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVY
Sbjct: 121 HCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVY 180
Query: 181 KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERY 240
KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERY
Sbjct: 181 KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERY 240
Query: 241 VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPT 300
VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPT
Sbjct: 241 VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPT 300
Query: 301 LEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT 360
LEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT
Sbjct: 301 LEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT 360
Query: 361 LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM 420
LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM
Sbjct: 361 LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM 420
Query: 421 AAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCR 480
AAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCR
Sbjct: 421 AAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCR 480
Query: 481 FQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFG 540
FQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFG
Sbjct: 481 FQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFG 540
Query: 541 SRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDD 600
SRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDD
Sbjct: 541 SRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDD 600
Query: 601 CPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVD 660
CPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVD
Sbjct: 601 CPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVD 660
Query: 661 GTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAG 720
GTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAG
Sbjct: 661 GTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAG 720
Query: 721 YEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQ 780
YEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQ
Sbjct: 721 YEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQ 780
Query: 781 GPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQ 840
GPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQ
Sbjct: 781 GPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQ 840
Query: 841 CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC 900
CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC
Sbjct: 841 CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC 900
Query: 901 DAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSC 960
DAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSC
Sbjct: 901 DAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSC 960
Query: 961 GPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCG 1020
GPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCG
Sbjct: 961 GPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCG 1020
Query: 1021 VGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPL 1080
VGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPL
Sbjct: 1021 VGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPL 1080
Query: 1081 VLKFQFCSRAYFRQMCCKTCQGH 1103
VLKFQFCSRAYFRQMCCKTCQGH
Sbjct: 1081 VLKFQFCSRAYFRQMCCKTCQGH 1103
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 1447 bits (3745), Expect = 0.0
Identities = 671/1114 (60%), Positives = 838/1114 (75%), Gaps = 22/1114 (1%)
Query: 8 LRWALALGLGLM-FEVTH--AFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQ 64
L W L+L + F H ++ SQ+EFL+ LE Y++ P RVD NGA L+F+ +
Sbjct: 8 LTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHS 67
Query: 65 RRGTGAT------AESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAA 118
RR A S+LF+K+++ HF LNLT ++ ++ H +VEYW ++G W+
Sbjct: 68 RRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDF 127
Query: 119 RPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSR--SPEESGP 176
+C Y G+LQ Q ST+ VA+S C GLHG+I ++EEY IEPL + S+ S E P
Sbjct: 128 LDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHP 187
Query: 177 HVVYKRSSLRHPHL--DTACGVRDEKPWKGRPWWLR-TLKPPPARPLGNETERGQPGLKR 233
HV+YK+S+L+ HL + CGV D G+PWWL T + P+ N + KR
Sbjct: 188 HVIYKKSALQQRHLYDHSHCGVSDFTR-SGKPWWLNDTSTVSYSLPINNTHIHHRQ--KR 244
Query: 234 SVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLIL 293
SVS ER+VETLVVADKMMV YHGR+D+E Y+L++MNIVAKL++DSSLG+ VNI+V RLI+
Sbjct: 245 SVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIV 304
Query: 294 LTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIY 353
LTEDQP LEI HHA KSLDSFCKWQKSI++H GN IPENG+A+HD AVLITRYDIC Y
Sbjct: 305 LTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTY 364
Query: 354 KNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARG 413
KNKPCGTLGLA V GMCE ERSCS+NEDIGL +AFTIAHEIGH FGMNHDG+GNSCG +G
Sbjct: 365 KNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKG 424
Query: 414 QDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAY 473
+ AKLMAAHIT TNPF WS+CSRDYITSFLDSG G CL+N PP++DF+YP VAPGQ Y
Sbjct: 425 HEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVY 484
Query: 474 DADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYK 533
DADEQCRFQ+G SRQCKYGEVC ELWCLSKSNRC+TNSIPAAEGTLCQT I+KGWCY+
Sbjct: 485 DADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQ 544
Query: 534 RVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRH 593
CVPFG+ P+ +DG WGPW+ WG+CSRTCGGGVSSS RHCDSP P+ GGKYCLGER+R+
Sbjct: 545 GDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRY 604
Query: 594 RSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTE 653
RSCNTD CP GS+DFRE QC++FD++PFRGK+Y WK Y GGGVK C+L CLAEG+NFYTE
Sbjct: 605 RSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTE 664
Query: 654 RAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFS 713
RA AV+DGT C D++DIC++GECKHVGCD +LGSD RED+CRVCGGDGS C+ IEG F+
Sbjct: 665 RAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFN 724
Query: 714 PASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAG 773
+ P GY +VV IP+GSVHI ++++ +S +++ALK + + + G P + +AG
Sbjct: 725 DSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAG 784
Query: 774 TTFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIAR----DSLPPYSW 829
T F ++ D+ +SLEALGP + +LIVMVL + + +RY+FN PI R D+ ++W
Sbjct: 785 TAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTW 844
Query: 830 HYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWV 889
++ PW++CSA CAGG Q Q V C+ D+S V +YC SK P+ QRACNTEPCPP+W
Sbjct: 845 NHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWF 904
Query: 890 VGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWA 949
+G+W CS++CD G+R+R+V+C R++ +EE+ LD S C RP E C+ +CPP+W
Sbjct: 905 IGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWV 964
Query: 950 ALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVA 1009
ALDWSECTP CGPG +HR+VLCKS+D T P A C +KPP +RC+L RCPP RWV
Sbjct: 965 ALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVT 1024
Query: 1010 GEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEEC 1069
G+WG+CSAQCG+GQ+ R+V+C S+TGQAS +C E +RPP+ QQCE+KCDS TP EEC
Sbjct: 1025 GDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDS-TPISNTEEC 1083
Query: 1070 KDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQGH 1103
KDVNKVAYCPLVLKF+FCSRAYFRQMCCKTCQGH
Sbjct: 1084 KDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH 1117
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 698 bits (1801), Expect = 0.0
Identities = 392/1047 (37%), Positives = 565/1047 (53%), Gaps = 77/1047 (7%)
Query: 37 ESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSR 96
+ Y P VD G+ ++ R++R + A S L Y+ ++ L L + S
Sbjct: 59 DDYVFVTPVEVDSAGSYISHDILHNGRKKR-SAQNARSSLHYRFSAFGQELHLEL-KPSA 116
Query: 97 LLAGHVSVEYWTREGLA-WQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEE 155
+L+ H V+ ++G + Q+ C Y G ++ +S+S VA+STC GL GLI + E
Sbjct: 117 ILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSS-VAVSTCAGLSGLIRTRKNE 175
Query: 156 YLIEPLH---GGPKGSRSPEESGPHVVYKR--------------SSLRHP-----HLDTA 193
+LI PL SP PHV+YKR S +P H+ A
Sbjct: 176 FLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHA 235
Query: 194 CGVRD---------EKPWKGRPWWLRTLKPPPARPLGNETERGQPGL-KRSVSRERY--- 240
R+ ++ + GR KPP E G G +RS + +
Sbjct: 236 SQSRETEYHHRRLQKQHFCGRRKKYAP-KPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLN 294
Query: 241 VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPT 300
VETLVVADK MV HG+ +V Y+L +MN+V+ LF+D ++GS +N++V LILL ++
Sbjct: 295 VETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGG 354
Query: 301 LEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT 360
L I HHA +SL+SFC+WQ +++ +G HD A+L+T +DIC +KN+PC T
Sbjct: 355 LLINHHADQSLNSFCQWQSALIGKNGK----------RHDHAILLTGFDICSWKNEPCDT 404
Query: 361 LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM 420
LG AP+ GMC + RSC++NED GL AFTIAHE GH FGM HDG GN C + +M
Sbjct: 405 LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCR---KAEGNIM 461
Query: 421 AAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQ-DFVYPTVAPGQAYDADEQC 479
+ +T F WSSCSR Y+ FL + CL + P + + YP PGQ YDAD QC
Sbjct: 462 SPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQC 521
Query: 480 RFQHGVKSRQCKYG---EVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVC 536
++Q G K++ C G ++C LWC +RC T +PAAEGT+C WC + C
Sbjct: 522 KWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSM----WCRQGQC 577
Query: 537 VPFGSR-PEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRS 595
V FG P + G W W+ W +CSRTCGGGV RHC++P+P GG +C G R ++
Sbjct: 578 VKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQL 637
Query: 596 CNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTY-RGGGVKACSLTCLAEGFNFYTER 654
CN + C S DFR QC+E++S PFRG FY+WK Y + C L C AE F F+
Sbjct: 638 CNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAM 697
Query: 655 AAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSP 714
+ V DGTPC P+ D+C+ G C+ VGCD LGS D C VC GD S C+ +G++
Sbjct: 698 SGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLN 757
Query: 715 ASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGT 774
Y VV IP G+ I IQ+L +S S+LA++ + L G P P AGT
Sbjct: 758 QHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGT 817
Query: 775 TFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPP------YS 828
TF+ ++ ++ + L A GP N +L+ +L + + P + +++ P + PP Y+
Sbjct: 818 TFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYT 877
Query: 829 WHYAPWTKCSAQCAGG-SQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPD 887
W ++CS C GG V+A+ R+Q ++ V +CSA +K + CN CP
Sbjct: 878 WSIVQ-SECSVSCGGGYINVKAICLRDQ--NTQVNSSFCSAKTKPVTEPKICNAFSCPAY 934
Query: 888 WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPE 947
W+ G WS CS++C G +SR + C ++ +E+A+ S CP P ++AC+ CPP+
Sbjct: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQ 994
Query: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP--- 1004
W+ WS+C+ +CG G+R R +LCK + TLP + C+ +P C L RCP
Sbjct: 995 WSLGPWSQCSKTCGRGVRKRELLCKGS-AAETLPESQCTSLPRPELQEGCVLGRCPKNSR 1053
Query: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCT 1031
+WVA W ECSA CG+G R+R ++C+
Sbjct: 1054 LQWVASSWSECSATCGLGVRKREMKCS 1080
Score = 167 bits (422), Expect = 7e-41
Identities = 101/299 (33%), Positives = 141/299 (47%), Gaps = 32/299 (10%)
Query: 823 SLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLD---SSAVAPHYCSAHSKLPKRQRAC 879
S P Y W W+ CS CAGG Q + ++C + AV C + P + +AC
Sbjct: 930 SCPAY-WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST--PTQVQAC 986
Query: 880 NTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEA 938
N+ CPP W +G WS CS++C GVR R ++C+ SAAE L +S C PRP + E
Sbjct: 987 NSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG--SAAE--TLPESQCTSLPRPELQEG 1042
Query: 939 CHGPTCPP----EWAALDWSECTPSCGPGLRHRVVLCKSADHRA---TLPPAHCSPAAKP 991
C CP +W A WSEC+ +CG G+R R + C + T P C KP
Sbjct: 1043 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP 1102
Query: 992 PATMR--CNLRRCPP-------ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECT 1042
+ CN R CP A W + W +C+ CG G + RSV C G+ S C
Sbjct: 1103 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ-GRPSSSCL 1161
Query: 1043 EALRPPTTQQCEAK-CDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
+PP + C C +P + P C D +C LV + C+ ++ + CCK+C
Sbjct: 1162 LHQKPPVLRACNTNFCPAPEKREDP-SCVDF--FNWCHLVPQHGVCNHKFYGKQCCKSC 1217
Score = 41.2 bits (95), Expect = 0.005
Identities = 22/51 (43%), Positives = 29/51 (56%), Gaps = 6/51 (11%)
Query: 555 PWGDCSRTCGGGVSSSSRHC-DSPRPTIGGKYCLGERRRH--RSCNTDDCP 602
PW C+ TCGGGV + S HC RP+ CL ++ R+CNT+ CP
Sbjct: 1131 PWQQCTVTCGGGVQTRSVHCVQQGRPS---SSCLLHQKPPVLRACNTNFCP 1178
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 684 bits (1766), Expect = 0.0
Identities = 396/1080 (36%), Positives = 570/1080 (52%), Gaps = 82/1080 (7%)
Query: 39 YEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLL 98
Y++ VDH G ++ +R+RR + L ++ F ++L SS L+
Sbjct: 60 YDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLV 119
Query: 99 AGHVSVEYWTREGLAWQRAARPH--CLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEY 156
A V+ + G + P C Y G L+ ++S VA+STC GL G+I +E +Y
Sbjct: 120 APGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSS-VALSTCQGLSGMIRTEEADY 178
Query: 157 LIEPL--HGGPKGSRSPEESGP-HVVYKRSS------------------LRHPHL---DT 192
+ PL H K R+ + S P HV+YKRS+ L H L D
Sbjct: 179 FLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDL 238
Query: 193 ACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGL--KRSVSR-----ERYVETLV 245
G+ ++ + GR + + PP L + + L KRS+ R E VETLV
Sbjct: 239 RLGLPQKQHFCGRR--KKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLV 296
Query: 246 VADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITH 305
V DK M+ HG ++ YVL I+N+V+ LF+D ++G +NI + LILL ++QP L I+H
Sbjct: 297 VVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISH 356
Query: 306 HAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAP 365
HA +L SFC+WQ ++ G HD A+L+T DIC +KN+PC TLG AP
Sbjct: 357 HADHTLSSFCQWQSGLMGKDG----------TRHDHAILLTGLDICSWKNEPCDTLGFAP 406
Query: 366 VGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHIT 425
+ GMC + RSC++NED GL AFTIAHE GH FGM HDG GN C + +M+ +
Sbjct: 407 ISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCK---KSEGNIMSPTLA 463
Query: 426 MKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP-PRQDFVYPTVAPGQAYDADEQCRFQHG 484
+ F WS CSR Y+ FL + +CL ++P P +++ YP PG+ YDA+ QC++Q G
Sbjct: 464 GRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFG 523
Query: 485 VKSRQCKYG---EVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGS 541
K++ C ++C LWC +C T +PAAEGT+C H + WC CV +G
Sbjct: 524 EKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICG-HDM---WCRGGQCVKYGD 579
Query: 542 R-PEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDD 600
P+ G W W+ W CSRTCGGGVS SR C +P+P+ GGK+C G R + CN+
Sbjct: 580 EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK 639
Query: 601 CPPGSQDFREVQCSEFDSIPFRGKFYKWKTY-RGGGVKACSLTCLAEGFNFYTERAAAVV 659
CP S DFR QC+E +S FRG+ YKWK Y + C L C+AEGF+F+ + V
Sbjct: 640 CPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVK 699
Query: 660 DGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGA 719
DGTPC D+ ++C+ G C+ VGCD VLGSD ED C VC G+ SAC G+++
Sbjct: 700 DGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTN 759
Query: 720 GYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLR 779
Y +V IP G+ I I ++N+S S+++++ L G P R +GTTF R
Sbjct: 760 QYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYR 819
Query: 780 QGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAP-IARDSLPP----YSWHYAPW 834
+ ++ ++L A GP N +LIV +L + P + + ++ P + + PP Y+W
Sbjct: 820 RSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVR- 878
Query: 835 TKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWS 894
++CS C GG C L V +C+ ++ C CPP W VGNWS
Sbjct: 879 SECSVSCGGGQMTVREGCYRDL-KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWS 937
Query: 895 LCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWS 954
CSR+C G +SR V C RRV + + + S CPQP P +AC+ +CPP W+A W+
Sbjct: 938 ACSRTCGGGAQSRPVQCTRRVH-YDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWA 996
Query: 955 ECTPSCGPGLRHRVVLCKSADHRA---TLPPAHCSPAAKPPATMRCNLRRC---PPARWV 1008
EC+ +CG G R R V CKS + A LP A C+ KP C L+RC +W+
Sbjct: 997 ECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWL 1056
Query: 1009 AGEWGECSAQCGVGQRQRSVRCT------SHTGQASHECTEALRPPTTQQCEAKCDSPTP 1062
W +CS C G ++R ++C + AS +C+ +P + + E C +P P
Sbjct: 1057 VSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKP--SLELERAC-APLP 1113
Score = 97.1 bits (240), Expect = 8e-20
Identities = 61/205 (29%), Positives = 91/205 (44%), Gaps = 28/205 (13%)
Query: 823 SLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSA---VAPHYCSAHSKLPKRQRAC 879
S PP +W PW +CS C G + +AV C++ S+ + C++ K P+ AC
Sbjct: 985 SCPP-AWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPK-PRMHEAC 1042
Query: 880 NTEPCPP----DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSAC---PQPR 932
+ C W+V WS CS +C+ G + R + C + + + + L C P+P
Sbjct: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Query: 933 PPVLEACHGPTCPPE------------WAALDWSECTPSCGPGLRHRVVLCKSADHRATL 980
+ AC CP W A WS+CT SCG G++ R V C +
Sbjct: 1103 LELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGR---- 1158
Query: 981 PPAHCSPAAKPPATMRCNLRRCPPA 1005
P + C KP A++ CN CP A
Sbjct: 1159 PASGCLLHQKPSASLACNTHFCPIA 1183
Score = 47.8 bits (112), Expect = 6e-05
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 13/77 (16%)
Query: 817 APIARDSLPPY--------SWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSA 868
AP+ PP+ SW +PW++C+A C GG Q ++V+C + C
Sbjct: 1110 APLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL----AGGRPASGCLL 1165
Query: 869 HSKLPKRQRACNTEPCP 885
H K P ACNT CP
Sbjct: 1166 HQK-PSASLACNTHFCP 1181
Score = 40.0 bits (92), Expect = 0.012
Identities = 28/79 (35%), Positives = 35/79 (44%), Gaps = 12/79 (15%)
Query: 533 KRVCVPFGSRPEGVDGAWGP----W--TPWGDCSRTCGGGVSSSSRHC-DSPRPTIGGKY 585
+R C P A GP W +PW C+ +CGGGV + S C RP G
Sbjct: 1106 ERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG--- 1162
Query: 586 CLGERRRHRS--CNTDDCP 602
CL ++ S CNT CP
Sbjct: 1163 CLLHQKPSASLACNTHFCP 1181
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 681 bits (1756), Expect = 0.0
Identities = 400/1004 (39%), Positives = 530/1004 (52%), Gaps = 75/1004 (7%)
Query: 40 EIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLA 99
+I P RVD G+ L++ P ++R ++ FY++ NLT + LLA
Sbjct: 44 DIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLA 103
Query: 100 GHVSVEYWTREGL--AWQRAARPHCLYAGHLQG-QASTSHVAISTCGGLHGLIVADEEEY 156
E R GL A RA P C G +Q + AIS C GL G+ E+Y
Sbjct: 104 PGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDY 163
Query: 157 LIEPLHGGPKGSRSPEESGPHVVYKRSSLRH------PHLDTACGVR-------DEKPWK 203
IEPL P P + PHVVYKR + + CGV+ + W+
Sbjct: 164 FIEPLDSAPA---RPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWE 220
Query: 204 GRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQY 263
R W R P R L +RSVS+E++VETLVVAD MV YHG+ VE Y
Sbjct: 221 QRQQWRR----PRLRRLH----------QRSVSKEKWVETLVVADAKMVEYHGQPQVESY 266
Query: 264 VLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVN 323
VL IMN+VA LF D S+G+ ++I + RL+LL +++ L+ITHHA +L SFCKWQKSI
Sbjct: 267 VLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSI-- 324
Query: 324 HSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIG 383
+ G+A P +HDTA+L+TR D+C N+PC TLGL+ V GMC+ RSCS+NED G
Sbjct: 325 -NMKGDAHP----LHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTG 379
Query: 384 LATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITS 443
L AFT+AHE+GH+FG+ HDG GN C G+ P +M+ + P WS CSR YIT
Sbjct: 380 LPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPF-IMSPQLLYDAAPLTWSRCSRQYITR 438
Query: 444 FLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCK-YGEVCSELWCL 502
FLD G GLCL++ P + +P+V PG YD QCR Q+G S C+ VC LWC
Sbjct: 439 FLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWC- 497
Query: 503 SKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRT 562
S C + A +GT C + WC CVP G RPE VDG W W+ W CSR+
Sbjct: 498 SVGTTCHSKLDAAVDGTRCG----ENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRS 553
Query: 563 CGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFR 622
CG GV S+ R C P P G+YC+GER+R R CN CP G FR VQCS FD++ ++
Sbjct: 554 CGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYK 613
Query: 623 GKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRP--DTVDICVSGECKHV 680
G+ + W V C L C F + AVVDGTPC + D+C++G CK+V
Sbjct: 614 GQLHTWVPV-VNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNV 672
Query: 681 GCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLN 740
GCD + S ED+C VC G+GS C T+ G F A G GY DV IP G+ I IQ++
Sbjct: 673 GCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAE-GLGYVDVGLIPAGAREIRIQEVA 731
Query: 741 LSLSHLALKG-DQESLLLEGLPGTPQPHRLPLAGTTF-QLRQGPDQVQSLEALGPINASL 798
+ + LAL+ D E L G +AGTTF R+G ++L + GP +
Sbjct: 732 EAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRG--NWENLTSPGPTKEPV 789
Query: 799 IVMVLARTELPALRYRF---NAPIARDSLPP--YSWHYAPWTKCSAQCAGGSQVQAVECR 853
+ +L + P + Y + D +PP +SWHY PWTKC+ C G Q Q V C
Sbjct: 790 WIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCL 849
Query: 854 NQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC-DAGVRSRSVVCQ 912
+ + V +C + +QR C+ +PCP W G W LCS SC G+ R+V+C
Sbjct: 850 ER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCI 908
Query: 913 RRVSAAEEKALDDSACPQ-PRPPVLEAC--HGPTCPPEWAALDWSECTPSCGPGLRHRVV 969
R V E+ AL+ AC PRPP C H P CP WA +WS+C+ +CG G + R V
Sbjct: 909 RSVGLDEQSALEPPACEHLPRPPTETPCNRHVP-CPATWAVGNWSQCSVTCGEGTQRRNV 967
Query: 970 LCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWG 1013
LC + C A +P + + C+L C RW G G
Sbjct: 968 LCTND------TGVPCDEAQQPASEVTCSLPLC---RWPLGTLG 1002
Score = 135 bits (341), Expect = 2e-31
Identities = 112/383 (29%), Positives = 154/383 (40%), Gaps = 66/383 (17%)
Query: 743 LSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPD-QVQSLEALGPINASLIVM 801
L +A+ G L GL P+P L GP Q +SL P+++ L+
Sbjct: 1327 LQTVAVWGTFLPTTLTGLGHMPEP----------ALNPGPKGQPESLSPEVPLSSRLLST 1376
Query: 802 VLARTELPALRYRFN-----APIARDSLPPYS--------WHYAPWTKCSAQCAGGSQVQ 848
+ PA +R AP ++ PP W W++CS C G+ +
Sbjct: 1377 --PAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWR 1434
Query: 849 AVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRS 908
V C + D A + P+ R C+ PC W GNWS CSRSC G R
Sbjct: 1435 PVRCSSGRDEDC-------APAGRPQPARRCHLRPCAT-WHSGNWSKCSRSCGGGSSVRD 1486
Query: 909 VVCQRRVSAAEEKALDDSAC-PQP-RPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRH 966
V C V + + L C P P +PP C C W W EC+ +CG G +
Sbjct: 1487 VQC---VDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCL-SWYTSSWRECSEACGGGEQQ 1542
Query: 967 RVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQR 1026
R+V C P C A +P T CN C +WV G WG+CS CG G ++R
Sbjct: 1543 RLVTCPE--------PGLCEEALRPNTTRPCNTHPC--TQWVVGPWGQCSGPCGGGVQRR 1592
Query: 1027 SVRC-TSHTG-------QASHEC-TEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAY 1077
V+C + TG Q HE E+ RP T+ CE P + P +D +
Sbjct: 1593 LVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCE-------PVEPPRCERDRLSFGF 1645
Query: 1078 CPLVLKFQFCSRAYFRQMCCKTC 1100
C + C R CC++C
Sbjct: 1646 CETLRLLGRCQLPTIRTQCCRSC 1668
Score = 36.6 bits (83), Expect = 0.13
Identities = 20/54 (37%), Positives = 23/54 (42%), Gaps = 5/54 (9%)
Query: 555 PWGDCSRTCGGGVSSSSRHCDSPR---PTIGGKYCLGER--RRHRSCNTDDCPP 603
PWG CS CGGGV C + + P C E R C T+DC P
Sbjct: 1577 PWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 641 bits (1653), Expect = 0.0
Identities = 374/1012 (36%), Positives = 539/1012 (53%), Gaps = 79/1012 (7%)
Query: 27 RSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPP----RRQRRGTGATAESRLFYKVAS 82
R Q+ F+ L Y + P RVD +G L++ P RR+R G+ E ++Y+++
Sbjct: 40 RRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGS--EDWVYYRISH 97
Query: 83 PSTHFLLNLTRSSRLLAGHVSVE--YWTREGLAWQRAARPHCLYAGH-LQGQASTSHVAI 139
NLT + L+ +E Y + ++ P C +G LQ A+
Sbjct: 98 EEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAAL 157
Query: 140 STCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESG--PHVVYKRSSLRHPHLDTACGVR 197
S C GL G ++ IEP+ P E G PH+VY+R + T CG++
Sbjct: 158 SACHGLTGFFQLPHGDFFIEPVKKHPL-----VEGGYHPHIVYRRQKVPETKEPT-CGLK 211
Query: 198 D-------EKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKM 250
D ++ W+ + W L P+R L +RS+S+ER+VETLVVAD
Sbjct: 212 DSVNISQKQELWREK-WERHNL---PSRSLS----------RRSISKERWVETLVVADTK 257
Query: 251 MVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKS 310
M+ YHG +VE Y+L IMN+V LF + S+G+ ++I+V RLILL E++ L+I HHA K+
Sbjct: 258 MIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKT 317
Query: 311 LDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMC 370
L SFCKWQKSI N + +HD AVL+TR DIC N+PC TLGL+ + GMC
Sbjct: 318 LSSFCKWQKSI-------NPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMC 370
Query: 371 ERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNP 430
+ RSC++NED GL AFTIAHE+GH+FG+ HDG N C G+ P +M+ + P
Sbjct: 371 QPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPY-IMSRQLQYDPTP 429
Query: 431 FVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC 490
WS CS +YIT FLD G G CL++ P ++ +APG YD QC+ Q+G + C
Sbjct: 430 LTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFC 489
Query: 491 KYGE-VCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGA 549
+ E VC LWC S C + AA+GT C +K WC C+ G +PE + G
Sbjct: 490 QEVENVCQTLWC-SVKGFCRSKLDAAADGTQCG----EKKWCMAGKCITVGKKPESIPGG 544
Query: 550 WGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFR 609
WG W+PW CSRTCG GV S+ R C++P P GGKYC GER+R+R CN C + FR
Sbjct: 545 WGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFR 604
Query: 610 EVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPC--RPD 667
++QCSEFD++P++ + Y W C L C F + AV+DGTPC +
Sbjct: 605 QMQCSEFDTVPYKNELYHWFPI-FNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGN 663
Query: 668 TVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWI 727
+ ++C++G CK VGCD + S+ ED+C VC GDGS+C+T+ +F G+GY D+ I
Sbjct: 664 SRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFK-QKEGSGYVDIGLI 722
Query: 728 PKGSVHIFIQDLNLSLSHLALKG-DQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQ 786
PKG+ I + ++ + + LA++ D E L G LAGT FQ + D ++
Sbjct: 723 PKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGD-LE 781
Query: 787 SLEALGPINASLIVMVLARTELPALRYRFNAPIARDSL------PPYSWHYAPWTKCSAQ 840
L A GP N S+ + +L + P ++Y + I +D L Y W Y WT+CS
Sbjct: 782 KLMATGPTNESVWIQLLFQVTNPGIKYEYT--IQKDGLDNDVEQQMYFWQYGHWTECSVT 839
Query: 841 CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC 900
C G + Q C + V +C ++ RQ+ C+ + CPP W G W CS +C
Sbjct: 840 CGTGIRRQTAHCIKK-GRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATC 898
Query: 901 DA-GVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEACHGP-TCPPEWAALDWSECT 957
G + R+V+C + + ++E+AL + C +P L +C+ CP +W +WSEC+
Sbjct: 899 GPHGEKKRTVLCIQTM-VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECS 957
Query: 958 PSCGPGLRHRVVLC-KSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWV 1008
SCG G+R R V C K+ D C KP + C L++CP +R V
Sbjct: 958 VSCGGGVRIRSVTCAKNHDE-------PCDVTRKPNSRALCGLQQCPSSRRV 1002
Score = 135 bits (340), Expect = 2e-31
Identities = 84/281 (29%), Positives = 123/281 (43%), Gaps = 35/281 (12%)
Query: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDW 888
W W++CS C G+ + VEC Q+DS C+A + P + C+ PC W
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQR-PDPAKRCHLRPCA-GW 1368
Query: 889 VVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPR---PPVLEACHGPTCP 945
VGNWS CSR+C G + R + C V + + + L C PP+ +C+ C
Sbjct: 1369 KVGNWSKCSRNCSGGFKIREIQC---VDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE 1425
Query: 946 PEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPA 1005
W WS+C+ SCG G++ R V C P C +P +TM CN C
Sbjct: 1426 A-WQVEPWSQCSRSCGGGVQERGVFC---------PGGLCDWTKRPTSTMSCNEHLC--C 1473
Query: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHE-----CTEALRPPTTQQCEAKCDSP 1060
W G W CS CG G ++R+V+C G + + C RPP ++C +
Sbjct: 1474 HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533
Query: 1061 TPGDGPEEC-KDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
+ C KD ++C + + CS R CC +C
Sbjct: 1534 S---ADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
Score = 105 bits (261), Expect = 3e-22
Identities = 57/171 (33%), Positives = 81/171 (47%), Gaps = 12/171 (7%)
Query: 888 WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEA-CHGPTCPP 946
W G+W+ CS +C G+R ++ C ++ + D P+ +P + CH CPP
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCD---PETQPNGRQKKCHEKACPP 884
Query: 947 EWAALDWSECTPSCGP-GLRHRVVLCKS---ADHRATLPPAHCSPAAKPPATMRCNLRRC 1002
W A +W C+ +CGP G + R VLC +D +A LPP C KP + CN
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQA-LPPTDCQHLLKPKTLLSCNRDIL 943
Query: 1003 PPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQC 1053
P+ W G W ECS CG G R RSV C + + C +P + C
Sbjct: 944 CPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE---PCDVTRKPNSRALC 991
Score = 100 bits (248), Expect = 1e-20
Identities = 54/181 (29%), Positives = 81/181 (44%), Gaps = 16/181 (8%)
Query: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKL-PKRQRACNTEP 883
P W W+KCS C+GG +++ ++C + D + P +C + + P +CN EP
Sbjct: 1364 PCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
Query: 884 CPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPT 943
C W V WS CSRSC GV+ R V C + ++ +C + CH
Sbjct: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHL-----CCH--- 1474
Query: 944 CPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRAT--LPPAHCSPAAKPPATMRCNLRR 1001
WA +W C+ SCG G + R V C ++ T C +PP +CN +
Sbjct: 1475 ----WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQA 1530
Query: 1002 C 1002
C
Sbjct: 1531 C 1531
Score = 45.4 bits (106), Expect = 3e-04
Identities = 18/52 (34%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAK 1056
A W+ G W ECS CG+G R V C++ Q +C RP ++C +
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVECST---QMDSDCAAIQRPDPAKRCHLR 1363
Score = 36.6 bits (83), Expect = 0.13
Identities = 31/124 (25%), Positives = 45/124 (36%), Gaps = 22/124 (17%)
Query: 555 PWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCS 614
PW CSR+CGGGV G +C G C+ P + E C
Sbjct: 1431 PWSQCSRSCGGGVQER------------GVFCPG-----GLCDWTKRPTSTMSCNEHLCC 1473
Query: 615 EFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVS 674
+ + G + T GGG + ++ C+ N ++ + D P RP C
Sbjct: 1474 HWAT----GNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKP-RPPEFKKCNQ 1528
Query: 675 GECK 678
CK
Sbjct: 1529 QACK 1532
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 596 bits (1537), Expect = e-170
Identities = 388/1164 (33%), Positives = 550/1164 (47%), Gaps = 162/1164 (13%)
Query: 29 QDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGAT-------------AESR 75
Q + L +L YEI P RV+ G + R +R AT S+
Sbjct: 38 QVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQ 97
Query: 76 LFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGL------AWQRAARPHCLYAGHLQ 129
Y++++ FL NLT ++ +A +V G+ + + A HC Y G++
Sbjct: 98 AHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVN 157
Query: 130 GQASTSHVA-ISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSS-LRH 187
++ H A IS C G+ G + + +Y IEPL + E++ PH++Y+RS+ R
Sbjct: 158 --TNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQRE 215
Query: 188 PHLDT-ACGV--------RDEKPWKGRPWWLRT------------LKPPPARPLGNETE- 225
P AC +D+K + R W R L GN+T+
Sbjct: 216 PSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDN 275
Query: 226 ----RGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLG 281
R KR +S R+VE LVVAD MV+YHG +++ Y+L +M+IVA +++D S+G
Sbjct: 276 TREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGE-NLQHYILTLMSIVASIYKDPSIG 334
Query: 282 STVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDT 341
+ +NI++ LI++ +Q I+ +A +L +FC+WQ H P G +HDT
Sbjct: 335 NLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQ--------HSKNSP--GGIHHDT 384
Query: 342 AVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMN 401
AVL+TR DIC +K C TLGLA +G +C+ RSCS++ED GL+TAFTIAHE+GH F M
Sbjct: 385 AVLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMP 443
Query: 402 HDGVGNSCGARG-QDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQ 460
HD N C G + P +MA + TNP++WS CSR YIT FLD+G G CL N P +
Sbjct: 444 HDD-NNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESR 502
Query: 461 DFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSN---RCITNSIPAAE 517
+ P PG Y+ ++QC G S+ C Y C LWC + + C T P A+
Sbjct: 503 PYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWAD 562
Query: 518 GTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSP 577
GT C+ C CVP DG+WG W+P+G CSRTCGGG+ ++ R C+ P
Sbjct: 563 GTECEPGK----HCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRP 618
Query: 578 RPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGK----FYKW-KTYR 632
P GGKYC+G R + +SCNT+ C +DFR+ QC+ FD F +W Y
Sbjct: 619 EPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYS 678
Query: 633 GGGVK-ACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLR 691
G +K C L C G Y + V+DGTPC DT DICV G C+ GCD VL S R
Sbjct: 679 GILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKAR 738
Query: 692 EDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLS-----LSHL 746
DKC VCGGD S+C+T+ G F+ GY VV IP G+ +I ++ + S ++L
Sbjct: 739 RDKCGVCGGDNSSCKTVAGTFNTVH--YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYL 796
Query: 747 ALKGDQESLLLEG-LPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLAR 805
AL + LL G T + + + V+ + + I L++ VL+
Sbjct: 797 ALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSV 856
Query: 806 TEL--PALRYRFNAPIARDSLPPYSWH-YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVA 862
+L P +RY FN PI D + W+ + PW CS C G + + V C + D V+
Sbjct: 857 GKLYNPDVRYSFNIPI-EDKPQQFYWNSHGPWQACSKPCQGERKRKLV-CTRESDQLTVS 914
Query: 863 PH--------------------------------------------YCSAHSKL------ 872
YC+ +S+L
Sbjct: 915 DQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEK 974
Query: 873 -----------PKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEK 921
P + C+ E W W+ CS+SCD G + R +C
Sbjct: 975 VDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVN----TRND 1030
Query: 922 ALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLP 981
LDDS C ++ C C P+W + DWSEC +CG G +HR V C+ + R L
Sbjct: 1031 VLDDSKCTHQEKVTIQRCSEFPC-PQWKSGDWSECLVTCGKGHKHRQVWCQFGEDR--LN 1087
Query: 982 PAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA---S 1038
C P KP + C C A W AG WG+CS CG G + R+V+C T +
Sbjct: 1088 DRMCDPETKPTSMQTCQQPEC--ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDD 1145
Query: 1039 HECTEALRPPTTQQCEAKCDSPTP 1062
++C A RP TQ CE P P
Sbjct: 1146 NDCNAATRPTDTQDCELPSCHPPP 1169
Score = 168 bits (426), Expect = 2e-41
Identities = 188/696 (27%), Positives = 253/696 (36%), Gaps = 158/696 (22%)
Query: 433 WSSCSRDYITSFLDSGL----GLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSR 488
W+ CS+ D G +C+N R D D +C Q V +
Sbjct: 1006 WTECSKS-----CDGGTQRRRAICVNTRNDVLD--------------DSKCTHQEKVTIQ 1046
Query: 489 QCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCY-------KRVCVPFGS 541
+C E W + C+ T + H + WC R+C P +
Sbjct: 1047 RCS--EFPCPQWKSGDWSECLV--------TCGKGHKHRQVWCQFGEDRLNDRMCDP-ET 1095
Query: 542 RPEGVDGAWGP----WT--PWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRS 595
+P + P W PWG CS TCG G + C I G Y
Sbjct: 1096 KPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKC------IIGTYM--SVVDDND 1147
Query: 596 CNTDDCPPGSQDFREVQCSEFDSIPF--RGKFYKWKT-YRGGGVKACSLTCLAEGFNFYT 652
CN P +QD C + P R + +T +R G CS TC Y
Sbjct: 1148 CNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYV 1207
Query: 653 ---ERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIE 709
+ +V D + C + EC C + D C V G G A +
Sbjct: 1208 SCRDENGSVADESACATLPRPVAKE-ECSVTPCGQWKALDW--SSCSVTCGQGRATRQVM 1264
Query: 710 GV-FSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHR 768
V +S D +IP+ QD ++S P P R
Sbjct: 1265 CVNYSDHVIDRSECDQDYIPETD-----QDCSMS---------------------PCPQR 1298
Query: 769 LPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYS 828
P +G L Q P Q + R R +P L
Sbjct: 1299 TPDSG----LAQHPFQNEDY-----------------------RPRSASPSRTHVLGGNQ 1331
Query: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDW 888
W PW CS+ CAGGSQ + V C+ D + + C K P QRAC + PCP W
Sbjct: 1332 WRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIK-PDEQRACESGPCP-QW 1386
Query: 889 VVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPE- 947
GNW C++ C G+R+R VVCQR + E+ D S +PP E C+ CP +
Sbjct: 1387 AYGNWGECTKLCGGGIRTRLVVCQR---SNGERFPDLSCEILDKPPDREQCNTHACPHDA 1443
Query: 948 -WAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPAR 1006
W+ WS C+ SCG G + R V C + D + L +C AKP +C RCP +
Sbjct: 1444 AWSTGPWSSCSVSCGRGHKQRNVYCMAKD-GSHLESDYCKHLAKPHGHRKCRGGRCP--K 1500
Query: 1007 WVAGEWGECSAQCGVGQRQRSVRCT--SHTGQASHECTEALRPPTTQQCEAKCDSPTPGD 1064
W AG W +CS CG G +QR V C +H EC RP + + C+
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQ---------- 1550
Query: 1065 GPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
GP CPL + RA Q C KTC
Sbjct: 1551 GPR----------CPL-----YTWRAEEWQECTKTC 1571
Score = 135 bits (339), Expect = 3e-31
Identities = 79/256 (30%), Positives = 120/256 (46%), Gaps = 20/256 (7%)
Query: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHY-CSAHSKLPKRQRACNTEPCPP- 886
W W++CS C G Q + V C Q+ + +A C+ +++ P+ +R C CP
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGC--QIGTHKIARETECNPYTR-PESERDCQGPRCPLY 1557
Query: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPV-LEACHGPTCP 945
W W C+++C G R R VVC + + + C + PV E+C C
Sbjct: 1558 TWRAEEWQECTKTCGEGSRYRKVVCVDD----NKNEVHGARCDVSKRPVDRESCSLQPCE 1613
Query: 946 PEWAALDWSECTPSCGPGLRHRVVLCKSA-----DHRATLPPAHCSPAAKPPATMRCNLR 1000
W +WSEC+ +CG G + R+V C ++ + P +PP+ C LR
Sbjct: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
Query: 1001 RCP-PARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDS 1059
CP A W G WG CS CGVG QRSV+C ++ Q SH C L+P + C +
Sbjct: 1674 DCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
Query: 1060 PTPGDGPEECKDVNKV 1075
+ P+ CK+V ++
Sbjct: 1734 ----ELPQNCKEVKRL 1745
Score = 94.4 bits (233), Expect = 5e-19
Identities = 55/185 (29%), Positives = 82/185 (44%), Gaps = 13/185 (7%)
Query: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
P Y+W W +C+ C GS+ + V C + + + V C SK P + +C+ +PC
Sbjct: 1555 PLYTWRAEEWQECTKTCGEGSRYRKVVCVDD-NKNEVHGARCDV-SKRPVDRESCSLQPC 1612
Query: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSA---CPQPRPPVLEACHG 941
W+ G WS CS +C G + R V C + E CP +PP + C+
Sbjct: 1613 EYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
Query: 942 PTCP--PEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAH-CSPAAKPPATMRC- 997
CP W +W C+ SCG G+ R V C + + + P+H C KP C
Sbjct: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQ----PSHLCHTDLKPEERKTCR 1728
Query: 998 NLRRC 1002
N+ C
Sbjct: 1729 NVYNC 1733
Score = 32.3 bits (72), Expect = 2.5
Identities = 17/64 (26%), Positives = 24/64 (37%), Gaps = 3/64 (4%)
Query: 821 RDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACN 880
RD +W W CS C G ++V+C D + H C K +R+ N
Sbjct: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPS---HLCHTDLKPEERKTCRN 1729
Query: 881 TEPC 884
C
Sbjct: 1730 VYNC 1733
Score = 31.6 bits (70), Expect = 4.3
Identities = 47/187 (25%), Positives = 68/187 (36%), Gaps = 42/187 (22%)
Query: 433 WSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKY 492
WSSCS + G G +Q VY G ++D R+C+
Sbjct: 1450 WSSCS-------VSCGRG-------HKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRG 1495
Query: 493 GEVCSELWCLSKSNRCITNSIPAAEGTL-----CQ--THTIDKGWCYKRVCVPFGSRPEG 545
G C + W ++C S+ G CQ TH I + + C P+ +RPE
Sbjct: 1496 GR-CPK-WKAGAWSQC---SVSCGRGVQQRHVGCQIGTHKIAR----ETECNPY-TRPES 1545
Query: 546 VDGAWGPWTP--------WGDCSRTCGGGVSSSSRHC-DSPRPTIGGKYCLGERR--RHR 594
GP P W +C++TCG G C D + + G C +R
Sbjct: 1546 ERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRE 1605
Query: 595 SCNTDDC 601
SC+ C
Sbjct: 1606 SCSLQPC 1612
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 580 bits (1496), Expect = e-165
Identities = 375/1100 (34%), Positives = 540/1100 (49%), Gaps = 81/1100 (7%)
Query: 7 ILRWALALGLGLMFEVTHAFR-----SQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPP 61
+ +W L L +T ++ Q+ + +L SYE+ P RV+ G + S
Sbjct: 3 VAKWLTGLLYHLSLFITRSWEVDFHPRQEALVRTLTSYEVVIPERVNEFGEVFPQSHHFS 62
Query: 62 RRQRRGTGATAES-RLFYKVASPSTHFLLNLTR-SSRLLAGHVSVEYWTREGLAWQRAAR 119
R++R R Y+ + F LNLT +S L AG+ V T E AW+ A
Sbjct: 63 RQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAG 122
Query: 120 P----HCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESG 175
P HC Y G + Q V +S CGGL G EY +EP+ +
Sbjct: 123 PSDLRHCFYRGQVNSQEDYKAV-VSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNK 181
Query: 176 PHVVYKRSSLRHPHLDTA--CGVRDEK------PWKGRPWWLRTLKPPPARPLGNET--- 224
PH++Y R L + L T C V + + P+ L R LG+ +
Sbjct: 182 PHLIY-RQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNV 240
Query: 225 ----ERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSL 280
ER KR +S RY+E +V AD +V+ HG +++ Y+L +M+IVA +++D S+
Sbjct: 241 PLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSI 299
Query: 281 GSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHD 340
G+ ++I+V +L+++ ++ I +L +FC WQ++ N + + ++HD
Sbjct: 300 GNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQT-------QNDLDDVHPSHHD 352
Query: 341 TAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGM 400
TAVLITR DIC K K C LGL+ +G +C+ +SC +NE+ GL +AFTIAHE+GHT G+
Sbjct: 353 TAVLITREDICSSKEK-CNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGV 411
Query: 401 NHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQ 460
HD C +MA ++ +P+ WS+CSR Y+T FLD+G G CL ++P +
Sbjct: 412 QHDD-NPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEE 470
Query: 461 DFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNR---CITNSIPAAE 517
+ P+ PG YD ++QC G S+ C + +C LWC S C T +P A+
Sbjct: 471 IYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPAD 530
Query: 518 GTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSP 577
GT C C +CV + V+G WGPW P+ CSRTCGGG+ S++R C+ P
Sbjct: 531 GTDCGPGM----HCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRP 586
Query: 578 RPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFD-------SIPFRGKFYKWKT 630
P GG YC+G R + RSCNTD CP G+QDFRE QCS+F+ IP ++
Sbjct: 587 EPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWL--PR 644
Query: 631 YRGGGVK-ACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSD 689
Y G G K C L C G N++ V DGTPC +T DICV G+C GCD VL S
Sbjct: 645 YSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSS 704
Query: 690 LREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLS----LSH 745
+ DKC VCGGD S+C+TI GVF+ S GY VV IP G+ ++ I+ + S S+
Sbjct: 705 AKIDKCGVCGGDNSSCKTITGVFN--SSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSY 762
Query: 746 LALKGDQESLLLEG---LPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMV 802
LAL + + L G L + + + T + + V+ + + LI+ V
Sbjct: 763 LALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQV 822
Query: 803 LARTEL--PALRYRFNAPIARDSLPPYSWH-YAPWTKCSAQCAGGSQVQAVECRNQLDSS 859
L L P + Y FN P+ S ++W Y PW C+ C G Q + + C ++ D S
Sbjct: 823 LCVGNLYNPDVHYSFNIPLEERS-DMFTWDPYGPWEGCTKMCQ-GLQRRNITCIHKSDHS 880
Query: 860 AVAPHYCSAHSKLPK-RQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQR-RVSA 917
V+ C H LP ++CNT+ C W V S CS C G R+ + C + +
Sbjct: 881 VVSDKECD-HLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHE 938
Query: 918 AEEKALDDSAC-PQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLC-KSAD 975
+ +DD C Q +PP E CHG W +WS+C+ SCG G R R C +
Sbjct: 939 GQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFG 998
Query: 976 HRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTG 1035
HR L C ++ CN CP W A EW EC CG G +QR V C +
Sbjct: 999 HR--LADNECQELSR-VTRENCNEFSCP--SWAASEWSECLVTCGKGTKQRQVWCQLNVD 1053
Query: 1036 QASHE-CTEALRPPTTQQCE 1054
S C + +P + CE
Sbjct: 1054 HLSDGFCNSSTKPESLSPCE 1073
Score = 157 bits (398), Expect = 4e-38
Identities = 89/240 (37%), Positives = 120/240 (50%), Gaps = 17/240 (7%)
Query: 819 IARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRA 878
+ S+ W PW CS+ C+GG Q +AV C+++ SA YC A SK P+ Q+
Sbjct: 1298 VVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA---SYCDAASKPPELQQ- 1353
Query: 879 CNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPVLE 937
C PCP W GNW CS++C G++SR V+CQ + L+D C +PP +
Sbjct: 1354 CGPGPCP-QWNYGNWGECSQTCGGGIKSRLVICQ----FPNGQILEDHNCEIVNKPPSVI 1408
Query: 938 ACHGPTCPPE--WAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATM 995
CH CP + W W+ C+ SCG G ++R V C R L +CS KPP
Sbjct: 1409 QCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQR-KLEDTNCSQVQKPPTHK 1467
Query: 996 RCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRC-TSHTGQASHE-CTEALRPPTTQQC 1053
C RCP W A W ECS CG G +QR V C GQ E C ++ RP + ++C
Sbjct: 1468 ACRSVRCP--SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRC 1525
Score = 134 bits (338), Expect = 4e-31
Identities = 79/233 (33%), Positives = 104/233 (44%), Gaps = 19/233 (8%)
Query: 829 WHYAPWTKCSAQCAGGSQVQAVECR----NQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
WH ++CS+QC G + + C ++ + V HYC K P Q C+
Sbjct: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLK-PPTQELCHGNCV 966
Query: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTC 944
W WS CSRSC G RSR C L D+ C + E C+ +C
Sbjct: 967 FTRWHYSEWSQCSRSCGGGERSRESYCMNNFG----HRLADNECQELSRVTRENCNEFSC 1022
Query: 945 PPEWAALDWSECTPSCGPGLRHRVVLCK-SADHRATLPPAHCSPAAKPPATMRCNLRRCP 1003
P WAA +WSEC +CG G + R V C+ + DH L C+ + KP + C L C
Sbjct: 1023 P-SWAASEWSECLVTCGKGTKQRQVWCQLNVDH---LSDGFCNSSTKPESLSPCELHTC- 1077
Query: 1004 PARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA---SHECTEALRPPTTQQC 1053
A W G WG C+ CG G + R V+C + A EC EA RP Q C
Sbjct: 1078 -ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSC 1129
Score = 134 bits (337), Expect = 5e-31
Identities = 83/285 (29%), Positives = 117/285 (41%), Gaps = 68/285 (23%)
Query: 828 SWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCP-- 885
SW PW C+ C G Q++ V+C N+L S+ + C S+ P +++C PC
Sbjct: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASR-PSDRQSCVLTPCSFI 1137
Query: 886 ----------------PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP 929
W G+W+ CS SC G ++R V C+ A ++ D+S C
Sbjct: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRD----ALDRIADESYCA 1193
Query: 930 Q-PRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPA 988
PRP + C P EW A DWS C+ SCG G R VLC + + + +C P
Sbjct: 1194 HLPRPAEIWDCFTPC--GEWQAGDWSPCSASCGHGKTTRQVLCMN--YHQPIDENYCDPE 1249
Query: 989 AKPPATMRCNLRRCPPA----------------------------------------RWV 1008
+P C+L CPPA +W
Sbjct: 1250 VRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWR 1309
Query: 1009 AGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQC 1053
G WG CS+ C G + R+V C GQ++ C A +PP QQC
Sbjct: 1310 TGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQC 1354
Score = 126 bits (316), Expect = 1e-28
Identities = 77/281 (27%), Positives = 118/281 (41%), Gaps = 57/281 (20%)
Query: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
P W W+ CSA C G + V C N + +YC + P ++ C+ C
Sbjct: 1207 PCGEWQAGDWSPCSASCGHGKTTRQVLCMNY--HQPIDENYCDPEVR-PLMEQECSLAAC 1263
Query: 885 PP-----------------------------------------DWVVGNWSLCSRSCDAG 903
PP W G W CS SC G
Sbjct: 1264 PPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGG 1323
Query: 904 VRSRSVVCQRRVSAAEEKALDDSAC-PQPRPPVLEACHGPTCPPEWAALDWSECTPSCGP 962
++ R+VVCQ +E S C +PP L+ C GP P+W +W EC+ +CG
Sbjct: 1324 LQHRAVVCQ------DENGQSASYCDAASKPPELQQC-GPGPCPQWNYGNWGECSQTCGG 1376
Query: 963 GLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP-PARWVAGEWGECSAQCGV 1021
G++ R+V+C+ + + L +C KPP+ ++C++ CP W W CSA CG
Sbjct: 1377 GIKSRLVICQFPNGQ-ILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGK 1435
Query: 1022 GQRQRSVRCTSHTGQASHE--CTEALRPPTTQQCEA-KCDS 1059
G++ R V C + + C++ +PPT + C + +C S
Sbjct: 1436 GRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPS 1476
Score = 85.9 bits (211), Expect = 2e-16
Identities = 76/309 (24%), Positives = 106/309 (34%), Gaps = 74/309 (23%)
Query: 828 SWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPD 887
SWH PWT CSA C G + + V C +Q + CS K P +AC + CP
Sbjct: 1420 SWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTN-CSQVQK-PPTHKACRSVRCP-S 1476
Query: 888 WVVGNWSLCS------------------------RSCDAGVR------------------ 905
W +W+ CS CD R
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGM 1536
Query: 906 -----SRSVVCQRRVSAAEEKALDDSACPQPRPPVLEA---------CHGPTCPPEWAAL 951
+ S C+R+ S + D+ Q V + C P C
Sbjct: 1537 ERGRLNCSTSCERKDSHQRMECTDNQI-RQVNEIVYNSSTISLTSKNCRNPPCNYIVVTA 1595
Query: 952 DWSECTPSCGPGLRHRVVLC-------KSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004
D S+C +CG R R+ C K HR P +C
Sbjct: 1596 DSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHL 1655
Query: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAK-CDSPTPG 1063
A W G+W +CS CG+G +R V+C + G +S C L+P ++C A C S T
Sbjct: 1656 ATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDCKSFT-- 1713
Query: 1064 DGPEECKDV 1072
CK++
Sbjct: 1714 ----TCKEI 1718
Score = 56.2 bits (134), Expect = 2e-07
Identities = 36/113 (31%), Positives = 45/113 (39%), Gaps = 11/113 (9%)
Query: 953 WSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP-ATMRCNLRRCPPARWVAGE 1011
W CT C GL+ R + C + + C P T CN C RW
Sbjct: 856 WEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD-CE-LRWHVIG 912
Query: 1012 WGECSAQCGVGQRQRSVRCTS---HTGQA----SHECTEALRPPTTQQCEAKC 1057
ECS+QCG G R + C H GQ H C + L+PPT + C C
Sbjct: 913 KSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNC 965
Score = 35.0 bits (79), Expect = 0.39
Identities = 25/83 (30%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 548 GAW--GPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERR--RHRSCNTDDCPP 603
G W G W+P CS +CG G ++ C + I YC E R + C+ CPP
Sbjct: 1209 GEWQAGDWSP---CSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPP 1265
Query: 604 GSQDFREVQCSEFDSIPFRGKFY 626
S F S P + +Y
Sbjct: 1266 AH--------SHFPSSPVQPSYY 1280
Score = 34.7 bits (78), Expect = 0.51
Identities = 13/26 (50%), Positives = 16/26 (61%)
Query: 556 WGDCSRTCGGGVSSSSRHCDSPRPTI 581
WG+CS+TCGGG+ S C P I
Sbjct: 1367 WGECSQTCGGGIKSRLVICQFPNGQI 1392
Score = 31.2 bits (69), Expect = 5.7
Identities = 37/155 (23%), Positives = 52/155 (33%), Gaps = 39/155 (25%)
Query: 433 WSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKY 492
WS CSR S C+NN R AD +C+ V C
Sbjct: 975 WSQCSRS-CGGGERSRESYCMNNFGHRL--------------ADNECQELSRVTRENCN- 1018
Query: 493 GEVCSELWCLSKSNRCITNSIPAAEGTL-----CQTHT--IDKGWCYKRVCVPFGSRPEG 545
E W S+ + C+ + +GT CQ + + G+C ++PE
Sbjct: 1019 -EFSCPSWAASEWSECL---VTCGKGTKQRQVWCQLNVDHLSDGFCNS------STKPES 1068
Query: 546 VDGA----WGPWT--PWGDCSRTCGGGVSSSSRHC 574
+ W PWG C+ TCG G C
Sbjct: 1069 LSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKC 1103
Score = 31.2 bits (69), Expect = 5.7
Identities = 23/109 (21%), Positives = 40/109 (36%), Gaps = 15/109 (13%)
Query: 555 PWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCS 614
PWG CS +C GG+ + C G+ + C+ PP Q C
Sbjct: 1312 PWGSCSSSCSGGLQHRAVVCQDEN---------GQSASY--CDAASKPPELQQCGPGPCP 1360
Query: 615 EFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTP 663
+++ G + + GGG+K+ + C + +V+ P
Sbjct: 1361 QWN----YGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPP 1405
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 541 bits (1395), Expect = e-153
Identities = 373/1121 (33%), Positives = 517/1121 (46%), Gaps = 134/1121 (11%)
Query: 40 EIAFPTRVDHNGALLAFSP--PPPRRQRRGTGATAESR-------LFYKVASPSTHFLLN 90
E+ P RV + L P P PRR+RR A R L + + L
Sbjct: 36 EVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQ 95
Query: 91 LTRSSRLLAGHVSVEYWTREGLAWQRAARPH--CLYAGHLQGQASTSHVAISTCG---GL 145
L R R L+ VE E A +R RP C Y+G + G S V++S CG GL
Sbjct: 96 LRRDLRFLSRGFEVE----EAGAARRRGRPAELCFYSGRVLGHPG-SLVSLSACGAAGGL 150
Query: 146 HGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSL------RHPHLDTACGVRDE 199
GLI +E+ LI+PL+ S+ P H++ ++ SL + C V E
Sbjct: 151 VGLIQLGQEQVLIQPLNN----SQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTE 206
Query: 200 KPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRD 259
K KP RP + ER ++ E VETLVVAD MV YHG
Sbjct: 207 KK-----------KPTWGRPSRDWRERRNA---IRLTSEHTVETLVVADADMVQYHGAEA 252
Query: 260 VEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQK 319
++++L +MN+V +FQ SLG +NI VT+L+LL + L I HH +SL+SFC WQ
Sbjct: 253 AQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQN 312
Query: 320 SIVNHSGH--GNAIP--ENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERS 375
+ + N +P ++ D AV +TR D C++K++PC T+G+A +GG+C +R
Sbjct: 313 EEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRK 372
Query: 376 CSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNP--FVW 433
C + ED GL AFTIAHE+GH GMNHD +SC R +M+ NP W
Sbjct: 373 CVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSH----IMSGEWVKGRNPSDLSW 428
Query: 434 SSCSRDYITSFLDSGLGLCLNNRPPRQDFVY--PTVAPGQAYDADEQCRFQHGVKSRQCK 491
SSCSRD + +FL S + CL PR P PG Y A+EQC+ G+ + C+
Sbjct: 429 SSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCR 488
Query: 492 YGE--VCSELWCLSKSNR-CITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDG 548
E +C+ LWCL + + C T P +GT C DK WC CV PE VDG
Sbjct: 489 NMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGA---DK-WCRAGECVSKTPIPEHVDG 544
Query: 549 AWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDF 608
W PW W CSRTCG G R CD+P P GG +C G H C CP G F
Sbjct: 545 DWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSF 604
Query: 609 REVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDT 668
R+ QC D + + K K C L C G A V+DGTPC P
Sbjct: 605 RDQQCQAHDRLSPKKKGLLTAVVVDD--KPCELYCSPLGKESPLLVADRVLDGTPCGPYE 662
Query: 669 VDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIP 728
D+CV G+C+ +GCD ++GS +ED+C VC GDG C ++G FS A G +D
Sbjct: 663 TDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHAR-GTALKDS---G 718
Query: 729 KGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQ-LRQGPDQVQS 787
KGS++ D + L P +AGTT + +R+G +
Sbjct: 719 KGSIN---SDWKIEL----------------------PGEFQIAGTTVRYVRRG--LWEK 751
Query: 788 LEALGPINASLIVMVLARTELP-ALRYRFNAPIAR------------DSLPPYSWHYAPW 834
+ A GP L +MVL + + Y + P+ R DSL + W ++ W
Sbjct: 752 ISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSL--FIWTHSGW 809
Query: 835 TKCSAQCAGGSQVQAVECRNQLDSSA--VAPHYCSAHSKLPKRQRACNTEPCPPDWVVGN 892
CS QC GG + V C ++ + V C S+ + R CN PC WV G
Sbjct: 810 EGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGP 869
Query: 893 WSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALD 952
WS CS +C+ G + R V C ++ A CP PRP +++C G C W A +
Sbjct: 870 WSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASE 929
Query: 953 WSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC-NLRRCPPARWVAGE 1011
WS+C+ SCG G+ R V C ++ + C + +P A C + C W G+
Sbjct: 930 WSQCSASCGKGVWKRTVACTNSQGK-------CDASTRPRAEEACEDYSGC--YEWKTGD 980
Query: 1012 WGECSAQCGVGQRQRSVRCTSH-TGQASHECTEALRPPTTQQC-EAKCD---------SP 1060
W CS+ CG G + R V+C TG+ EC +P +QC + C+ SP
Sbjct: 981 WSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANTITSP 1040
Query: 1061 TPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ 1101
+C YC ++ + C + Q CC+TC+
Sbjct: 1041 RLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCR 1081
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 496 bits (1278), Expect = e-140
Identities = 368/1134 (32%), Positives = 519/1134 (45%), Gaps = 111/1134 (9%)
Query: 29 QDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESR-----LFYKVASP 83
+DE L S E + GA ++ PPPP + + + ++ +
Sbjct: 113 EDEELESQELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAF 172
Query: 84 STHFLLNLTRSSRLLAGHVSVEYWTREG-------LAWQRAARPH--CLYAGHLQGQAST 134
S L L R R LA +VE G A Q A P C Y G +
Sbjct: 173 SRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPG- 231
Query: 135 SHVAISTCGG-LHGLIVADEEEYLIEPLH------GGPKGSRSPEESGPHVVYKRSSLRH 187
S + STCGG L G I +E+ IEPL+ G P + S V ++S+L H
Sbjct: 232 SLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSAL-H 290
Query: 188 PHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVA 247
H CG+ +K GRP +R + E+ RG+ + +E +ET+VVA
Sbjct: 291 SHY---CGIISDK---GRP---------RSRKIA-ESGRGKR-YSYKLPQEYNIETVVVA 333
Query: 248 DKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHA 307
D MV+YHG +++L I+N+V LFQ SL VN+ V +LILL E P L I HH
Sbjct: 334 DPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHG 393
Query: 308 GKSLDSFCKWQKSIVNHSGHGNAIPENGVANH-------DTAVLITRYDICIYKNKPCGT 360
K L+SFCKWQ G N I N D A+LITR D C++K++PC T
Sbjct: 394 EKMLESFCKWQHE---EFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDT 450
Query: 361 LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM 420
+G+A + GMC +R C + ED GL AFTIAHE+GH G+NHD SC D +M
Sbjct: 451 VGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCA----DGLHIM 506
Query: 421 AAHITMKTN--PFVWSSCSRDYITSFLDSGLGLCLNNRPPRQ--DFVYPTVAPGQAYDAD 476
+ N WS CS++ + FL S CL P+ + P+ PG Y AD
Sbjct: 507 SGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTAD 566
Query: 477 EQCRFQHGVKSRQCKYGE--VCSELWCLSKSNR-CITNSIPAAEGTLCQTHTIDKG-WCY 532
EQC+ G + C+ + +C+ LWC + + C T P +GT C D G WC
Sbjct: 567 EQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDC-----DLGKWCK 621
Query: 533 KRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRR 592
C S PE + G W W+P CSRTC G+SS R C P + C G R++
Sbjct: 622 AGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQ 676
Query: 593 HRSCNTDDCPPGSQDFREVQCSEFDSIPFRGK-FYKWKTYRGGGVKACSLTCLAEGFNFY 651
+R C CP G FR+ QC + K +W+ K C+L C G
Sbjct: 677 YRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEE-KPCALFCSPVGKEQP 735
Query: 652 TERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGV 711
+ V+DGT C +DIC +G C+ VGCD +LGS RED C VC G+G +C+ I+G
Sbjct: 736 ILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGD 795
Query: 712 FSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPL 771
F+ GAGY +V+ IP G+ I + + + S+LAL+ D + L
Sbjct: 796 FNHTR-GAGYVEVLVIPAGARRIKVVEEKPAHSYLALR-DAGKQSINSDWKIEHSGAFNL 853
Query: 772 AGTTFQ-LRQGPDQVQSLEALGPINASLIVMVLA-RTELPALRYRFNAPI--------AR 821
AGTT +R+G + + A GP A L ++VL + + L Y + P ++
Sbjct: 854 AGTTVHYVRRG--LWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSK 911
Query: 822 DSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDS--SAVAPHYCSAHSKLPKRQRAC 879
P + W + W C A C GG + V C + S V C +K + R C
Sbjct: 912 APEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKC 971
Query: 880 NTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEAC 939
N +PC W++ W+ CSR+C G++SR V C +++S + C P+P + C
Sbjct: 972 NEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRC 1031
Query: 940 HGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC-N 998
G C W A WSEC+ CG G+RHR V C T P C + +P C +
Sbjct: 1032 EGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC-------TNPRKKCVLSTRPREAEDCED 1084
Query: 999 LRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSH-TGQASHEC-----TEALRPPTTQQ 1052
+C W G+W +CS CG G + R ++C TG+ +EC A RP Q
Sbjct: 1085 YSKC--YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQP 1142
Query: 1053 CEAKCD-----SPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ 1101
C K + SP +C YC ++ + C + Q CC+TC+
Sbjct: 1143 CNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCR 1196
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 494 bits (1273), Expect = e-139
Identities = 334/1066 (31%), Positives = 498/1066 (46%), Gaps = 118/1066 (11%)
Query: 74 SRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQAS 133
S LFY V L L ++RL+A ++E+ +G CLY G + G A
Sbjct: 107 SHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAE 166
Query: 134 TSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSLRHP----- 188
S VA+S C GL GLI +EEE+ IEPL G ++ E+ HVVY+R P
Sbjct: 167 ASSVALSNCDGLAGLIRMEEEEFFIEPLEKG-LAAQEAEQGRVHVVYRRPPTSPPLGGPQ 225
Query: 189 HLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRS----VSRERYVETL 244
LDT + L +L +R LG E +R+ + +E L
Sbjct: 226 ALDTGASLDS----------LDSL----SRALGVLEEHANSSRRRARRHAADDDYNIEVL 271
Query: 245 VVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLT--EDQPTLE 302
+ D +V +HG+ V++Y+L +MNIV +++ D SLG+ +N+++ R+ILL+ + +E
Sbjct: 272 LGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIE 331
Query: 303 ITHHAGKSLDSFCKW----QKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPC 358
I + + +SL++ C+W QK H + HD A+ +TR D P
Sbjct: 332 IGNPS-QSLENVCRWAYLQQKPDTGHDEY-----------HDHAIFLTRQDF-----GPS 374
Query: 359 GTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAK 418
G G APV GMC RSC++N + G ++AF +AHE GH GM HDG GN CG +
Sbjct: 375 GMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVR-LGS 433
Query: 419 LMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQ 478
+MA + + F WS CS+ ++ +L S CL + P D+ PG Y +EQ
Sbjct: 434 IMAPLVQAAFHRFHWSRCSQQELSRYLHSYD--CLLDDPFAHDWPALPQLPGLHYSMNEQ 491
Query: 479 CRFQHGVKSRQC---KYGEVCSELWCLSKSNR--CITNSIPAAEGTLCQTHTIDKGWCYK 533
CRF G+ C + + C +LWC N C T P +GT+C C+K
Sbjct: 492 CRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGK----HCFK 547
Query: 534 RVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRH 593
C+ DG+WG W+P+G CSRTCG GV +R CD+P P GG+ C G
Sbjct: 548 GHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDF 607
Query: 594 RSCNTDDCPPGSQDFREVQCSEFDSIPFRGKF-YKWKTYRGGGVK-ACSLTCLAEGFNFY 651
+ C+ DCP DFRE QC ++D G + W + K C L C +
Sbjct: 608 QLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEV 667
Query: 652 TERAAAVVDGTPCR-PDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEG 710
V DGT C D +CV G+C+ VGCD V+GS +EDKC VCGGD S C+ ++G
Sbjct: 668 VSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKG 727
Query: 711 VFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQ--ESLLLEGLPGTPQPHR 768
F+ + GY + IP G+ H+ IQ+++ + HLA+K + + +L E
Sbjct: 728 TFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKT 787
Query: 769 LPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTEL-PALRYRF-----------N 816
G ++ R D ++L+ +GP++ ++ V+V+ + +L Y++ N
Sbjct: 788 FIAMGVEWEYRD-EDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDN 846
Query: 817 APIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQ 876
+ DS+ Y W W+ CS C GGSQ CR +LD V +C+A SK +
Sbjct: 847 NVLEEDSV-VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIR 905
Query: 877 RACNTEPC-PPDWVVGNWSLCSRSCD-AGVRSRSVVCQRRVSAAEEKALDDSACPQPRPP 934
RACN + C P WV G W CS++C G++ RSV C + + +++ C RP
Sbjct: 906 RACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPE 965
Query: 935 VLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPAT 994
AC CP W A WS+C+ +CG G + R VLC++AD + +P
Sbjct: 966 SRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGI-----CQEERPETA 1020
Query: 995 MRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCE 1054
C L CP R S + S+ RP
Sbjct: 1021 RTCRLGPCP-------------------------RNISDPSKKSYVVQWLSRPDP----- 1050
Query: 1055 AKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
DSP + +K +C + + ++CS + ++CCK+C
Sbjct: 1051 ---DSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 474 bits (1220), Expect = e-133
Identities = 318/1022 (31%), Positives = 475/1022 (46%), Gaps = 106/1022 (10%)
Query: 39 YEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAE-SRLFYKVASPSTHFLLNLTRSSRL 97
YE+ P + G L+ + ++R ++ +LF+ + + F L L +++L
Sbjct: 42 YELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQL 101
Query: 98 LAGHVSVEYWT---------------REGLAWQRAARP-----HCLYAGHLQGQASTSHV 137
+A VE+ + G A R + +C Y G + TS V
Sbjct: 102 VAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTS-V 160
Query: 138 AISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGP-HVVYKRSSLRHPHLDTACGV 196
AIS C GL G+I +D EEY IEPL +G + EE G HVVYKRS++ +D +
Sbjct: 161 AISNCDGLAGMIKSDNEEYFIEPLE---RGKQMEEEKGRIHVVYKRSAVEQAPIDMS--- 214
Query: 197 RDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERY-------VETLVVADK 249
K + R L L LG L ++ R R+ +E L+ D
Sbjct: 215 ---KDFHYRESDLEGLDD-----LGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDD 266
Query: 250 MMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITH-HAG 308
+V +HG+ V+ Y+L +MNIV +++ D SLG +N+++ R+I+L + I +
Sbjct: 267 SVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPS 326
Query: 309 KSLDSFCKW----QKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLA 364
+SL++ C+W Q+S +NHS H HD A+ +TR D P G G A
Sbjct: 327 RSLENVCRWASQQQRSDLNHSEH-----------HDHAIFLTRQDF-----GPAGMQGYA 370
Query: 365 PVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHI 424
PV GMC RSC++N + G ++AF +AHE GH GM HDG GN CG +MA +
Sbjct: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA-MGSVMAPLV 429
Query: 425 TMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHG 484
+ + WS CS + ++ S CL + P D+ PG Y DEQCRF G
Sbjct: 430 QAAFHRYHWSRCSGQELKRYIHSYD--CLLDDPFDHDWPKLPELPGINYSMDEQCRFDFG 487
Query: 485 VKSRQC---KYGEVCSELWCLSKSNR--CITNSIPAAEGTLCQTHTIDKGWCYKRVCVPF 539
V + C + + C +LWC N C T P +GT C WCYK C+
Sbjct: 488 VGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGK----WCYKGHCMWK 543
Query: 540 GSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTD 599
+ + DG WG WT +G CSRTCG GV +R C++P P GG+ C G ++ CNT+
Sbjct: 544 NANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTE 603
Query: 600 DCPPGSQDFREVQCSEFDS-IPFRGKFYKWKTY-RGGGVKACSLTCLAEGFNFYTERAAA 657
+C +DFR QC + +S ++ + W Y K C L C ++
Sbjct: 604 ECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQL 663
Query: 658 VVDGTPCR-PDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPAS 716
V DGT C D ICV GEC VGCD+ +GS+ EDKC VCGGD S C T++G F+
Sbjct: 664 VHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTP 723
Query: 717 PGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQES-LLLEGLPGTPQPHRLPLAGTT 775
GY + IP G+ H+ IQ+ S LA+K +L G + G
Sbjct: 724 RKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVE 783
Query: 776 FQLRQGPDQVQSLEALGPINASLIVMVLARTE--LPALRYRF-----------NAPIARD 822
+ D ++SL GP++ +IV+++ + +L Y++ + + ++
Sbjct: 784 WDYNI-EDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQE 842
Query: 823 SLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTE 882
L + W W++CS C GG Q CR + D+ V +C A+ K +R CN +
Sbjct: 843 ELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQ 902
Query: 883 PCP-PDWVVGNWSLCSRSC-DAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACH 940
C P WV W C+++C +G + R+V C + + +++ C RP C+
Sbjct: 903 ECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCN 962
Query: 941 GPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLR 1000
CP +W WSEC+ +CG G R VLC++ DH KP + C L
Sbjct: 963 RVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH---------CDGEKPESVRACQLP 1013
Query: 1001 RC 1002
C
Sbjct: 1014 PC 1015
Score = 43.9 bits (102), Expect = 8e-04
Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 10/70 (14%)
Query: 826 PYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCP 885
P W PW++CS C G++V+ V CR A +C P+ RAC PC
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCR--------AGDHCDGEK--PESVRACQLPPCN 1016
Query: 886 PDWVVGNWSL 895
+ +G+ S+
Sbjct: 1017 DEPCLGDKSI 1026
Score = 30.8 bits (68), Expect = 7.4
Identities = 29/117 (24%), Positives = 48/117 (41%), Gaps = 26/117 (22%)
Query: 997 CNLRRCPP---ARWVAGEW---GECSAQCGVGQRQRSVRCTSHT--GQASHECTEALRPP 1048
C ++ PP AG+W G C + Q+++ S T G S C +R
Sbjct: 516 CKTKKGPPLDGTECAAGKWCYKGHCMWK-NANQQKQDGNWGSWTKFGSCSRTCGTGVRFR 574
Query: 1049 TTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCS----RAYFRQMCCKTCQ 1101
T Q C++P P +G ++C VN ++Q C+ + +F + CQ
Sbjct: 575 TRQ-----CNNPMPINGGQDCPGVN--------FEYQLCNTEECQKHFEDFRAQQCQ 618
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 473 bits (1216), Expect = e-133
Identities = 292/840 (34%), Positives = 425/840 (50%), Gaps = 75/840 (8%)
Query: 121 HCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPK--GSRSPEESGPHV 178
HC Y+G + G S++ A+S C G+ G E Y I+PL + + +P E P
Sbjct: 122 HCFYSGTVNGDPSSA-AALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAP 180
Query: 179 VYKRSSLRHPHLDTA--CGVRDEKPW------------------KGRPWWLRTLKPPPAR 218
+ R+ D CGV D++P +G W + + P +
Sbjct: 181 LQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQW---SPQDPALQ 237
Query: 219 PLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDS 278
+G T G KR VS RYVET++VAD+ M +HG ++ Y+L + ++ A+L++
Sbjct: 238 GVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGS-GLKHYLLTLFSVAARLYKHP 296
Query: 279 SLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVAN 338
S+ ++V+++V +++++ ++Q E+T +A +L +FC WQK N + +
Sbjct: 297 SIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQ-------HNPPSDRDAEH 349
Query: 339 HDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTF 398
+DTA+L TR D+C ++ C TLG+A VG +C+ RSCSV ED GL AFT AHE+GH F
Sbjct: 350 YDTAILFTRQDLC--GSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVF 407
Query: 399 GMNHDGVGNSCGARG-QDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
M HD G + +MA+ ++ + WS CS ITSFLD+G G CL ++P
Sbjct: 408 NMPHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP 467
Query: 458 PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCK-YGEVCSELWCLSKSNR---CITNSI 513
+ P PG +YDA+ QC+F G S+ C CS LWC S C T
Sbjct: 468 -QNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHF 526
Query: 514 PAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE---GVDGAWGPWTPWGDCSRTCGGGVSSS 570
P A+GT C + WC CV R G+WG W PWGDCSRTCGGGV +
Sbjct: 527 PWADGTSCG----EGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYT 582
Query: 571 SRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGS-QDFREVQC---SEFDSIPF-RGKF 625
R CD+P P GGKYC G+R R+RSCN +DCP + + FRE QC +EF F G
Sbjct: 583 MRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPA 642
Query: 626 YKW-KTYRGGGVK-ACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCD 683
+W Y G K C L C A+G ++ VVDGTPC PD+ +CV G+C GCD
Sbjct: 643 VEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCD 702
Query: 684 RVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNL-- 741
R++ S + DKC VCGG+GS C+ I G + A P GY D++ IP G+ +I ++ N
Sbjct: 703 RIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKP--GYHDIITIPTGATNIEVKQRNQRG 760
Query: 742 ---SLSHLALKGDQESLLLEG-LPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINAS 797
+ S LA+K + +L G + + G + ++ + + P+
Sbjct: 761 SRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEP 820
Query: 798 LIVMVL--ARTELPALRYRFNAPIARDS---LPPYS-WHYAPWTKCSAQCAGGSQVQAVE 851
L + VL P ++Y + ++S +P +S W W +CS C G Q + VE
Sbjct: 821 LTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVE 880
Query: 852 CRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVC 911
CR D + C+ K P R C PC P W +G WS CS++C G + RS+ C
Sbjct: 881 CR---DINGQPASECAKEVK-PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKC 935
Score = 80.5 bits (197), Expect = 8e-15
Identities = 38/102 (37%), Positives = 55/102 (53%), Gaps = 6/102 (5%)
Query: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARW 1007
W +W EC+ SC G + R+V C+ + + P + C+ KP +T C CP +W
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ---PASECAKEVKPASTRPCADHPCP--QW 912
Query: 1008 VAGEWGECSAQCGVGQRQRSVRCTSHTGQA-SHECTEALRPP 1048
GEW CS CG G ++RS++C SH G SHE + L+ P
Sbjct: 913 QLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 10/131 (7%)
Query: 874 KRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSAC-PQPR 932
K++ + N P WV+ W CS+SC+ G + R V C+ + S C + +
Sbjct: 844 KKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECR------DINGQPASECAKEVK 897
Query: 933 PPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP 992
P C C P+W +WS C+ +CG G + R + C S D L C P KP
Sbjct: 898 PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKCLSHD-GGVLSHESCDPLKKPK 955
Query: 993 ATMR-CNLRRC 1002
+ C + C
Sbjct: 956 HFIDFCTMAEC 966
Score = 54.3 bits (129), Expect = 6e-07
Identities = 23/56 (41%), Positives = 32/56 (57%), Gaps = 3/56 (5%)
Query: 1007 WVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTP 1062
WV EWGECS C +G ++R V C GQ + EC + ++P +T+ C D P P
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPC---ADHPCP 910
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 468 bits (1205), Expect = e-131
Identities = 326/911 (35%), Positives = 438/911 (48%), Gaps = 98/911 (10%)
Query: 66 RGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYW--TREGLAWQRAARPHCL 123
RG + + L +++ + F L+LT ++ LA S E+ +GL + C
Sbjct: 43 RGPEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCF 102
Query: 124 YAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRS 183
Y+G + + S A+S CGGL G EY+I PL + G H++ +R
Sbjct: 103 YSGDVNAEPD-SFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRG 161
Query: 184 SLRHPHLD--TACGVRDEKPWKGRPWWLRTLKPPPARPLG---NETERGQPGLKRSVSRE 238
P D + CGV W P LR L P R G + + R KR VS
Sbjct: 162 VPGGPSGDPTSRCGVASG--WN--PAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIP 217
Query: 239 RYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQ 298
RYVETLVVAD+ MV +HG D+E Y+L ++ A+L++ S+ + +NI+V +++LL +
Sbjct: 218 RYVETLVVADESMVKFHGA-DLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRD 276
Query: 299 PTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPC 358
++T +A +L +FC WQK + N + + DTA+L TR D+C C
Sbjct: 277 SGPKVTGNAALTLRNFCAWQKKL-------NKVSDKHPEYWDTAILFTRQDLC--GATTC 327
Query: 359 GTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAK 418
TLG+A VG MC+ +RSCSV ED GL +AFT AHE+GH F M HD V G K
Sbjct: 328 DTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFG----K 383
Query: 419 LMAAHITMKT-------NPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQ 471
L A H+ T NP WS+CS IT FLDSG G CL ++P + P PG
Sbjct: 384 LRANHMMSPTLIQIDRANP--WSACSAAIITDFLDSGHGDCLLDQPSKP-ISLPEDLPGA 440
Query: 472 AYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNR---CITNSIPAAEGTLCQTHTIDK 528
+Y +QC GV S+ C Y + C++LWC K+ C T P A+GT C +
Sbjct: 441 SYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKL-- 498
Query: 529 GWCYKRVCVP-FGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCL 587
C K CV VDG+W W P+G CSRTCGGGV + R C +P P GGKYC
Sbjct: 499 --CLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCE 556
Query: 588 GERRRHRSCNTDDCPPGS--QDFREVQCSEFDSIPFRGK----FYKW-KTYRGGGVK-AC 639
G R ++RSCN + CP + + FRE QC F+ W Y G + C
Sbjct: 557 GVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKC 616
Query: 640 SLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCG 699
L C A G ++ A VVDGT C PD+ +CV G+C GCD LGS R DKC VCG
Sbjct: 617 KLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCG 676
Query: 700 GDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQD-----LNLSLSHLALKGDQES 754
GD +C+ + G+F+ P GY VV IP G+ I I+ L ++LALK Q
Sbjct: 677 GDNKSCKKVTGLFT--KPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGK 734
Query: 755 LLLEGLPGTPQPHR-LPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTEL--PAL 811
LL G R L + G+ + V+SL+A PI L V VL+ ++ P +
Sbjct: 735 YLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRV 794
Query: 812 RYRFNAP-------------------------------IARDSLPPYSWHYAPWTKCSAQ 840
RY F P D PP W W CSA
Sbjct: 795 RYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSAS 854
Query: 841 CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC 900
C G Q +AV+CR V P +AH P +AC EPC P W + WS CS+SC
Sbjct: 855 CGSGLQKRAVDCRGSAGQRTV-PACDAAHR--PVETQACG-EPC-PTWELSAWSPCSKSC 909
Query: 901 DAGVRSRSVVC 911
G + RS+ C
Sbjct: 910 GRGFQRRSLKC 920
Score = 73.2 bits (178), Expect = 1e-12
Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 7/111 (6%)
Query: 945 PPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004
P W A W C+ SCG GL+ R V C+ + + T+P C A +P T C CP
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA--CDAAHRPVETQACG-EPCP- 895
Query: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQ--ASHECTEALRPPTTQQC 1053
W W CS CG G ++RS++C H G+ A +C +P C
Sbjct: 896 -TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
Score = 62.8 bits (151), Expect = 2e-09
Identities = 29/56 (51%), Positives = 33/56 (58%), Gaps = 1/56 (1%)
Query: 1003 PPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQAS-HECTEALRPPTTQQCEAKC 1057
PPARWVAG WG CSA CG G ++R+V C GQ + C A RP TQ C C
Sbjct: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPC 894
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 433 bits (1114), Expect = e-121
Identities = 332/1111 (29%), Positives = 478/1111 (43%), Gaps = 142/1111 (12%)
Query: 44 PTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVS 103
PT H+ L P G L++ V L L + RL+ S
Sbjct: 74 PTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSS 133
Query: 104 VEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHG 163
VE+ +++ R C+Y G + G + VAIS C GL GLI D ++ IEPL
Sbjct: 134 VEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE- 191
Query: 164 GPKGSRSPEESG-PHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGN 222
+G + E SG HVVY+R +++ + + +E G L L LG+
Sbjct: 192 --RGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGD---LPNLLGLVGDQLGD 246
Query: 223 ETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGS 282
+ + S S +E L+V D +V +HG+ V+ YVL +MNIV +++ D SLG
Sbjct: 247 TERKRRHAKPGSYS----IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGV 302
Query: 283 TVNILVTRLILLTEDQPTLEITH-HAGKSLDSFCKW----QKSIVNHSGHGNAIPENGVA 337
+NI + RLI++ Q I + +SL+ C+W Q+ +H+ H
Sbjct: 303 HINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEH---------- 352
Query: 338 NHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHT 397
HD V +TR D P G G APV GMC RSC++N + G ++AF IAHE GH
Sbjct: 353 -HDHVVFLTRQDF-----GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHV 406
Query: 398 FGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
GM HDG GN C A +MA + + F WS CS+ ++ +L S CL + P
Sbjct: 407 LGMEHDGQGNGC-ADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYD--CLLDDP 463
Query: 458 PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC---KYGEVCSELWCLSKSNR--CITNS 512
+ P PG Y DEQCRF G + C + E C +LWC N C T
Sbjct: 464 FDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKK 523
Query: 513 IPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE---GVDGAWGPWTPWGDCSRTCGGGVSS 569
P +GT C WC+K C+ PE G DG W WT +G CSR+CGGGV S
Sbjct: 524 GPPLDGTECAPGK----WCFKGHCI--WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 577
Query: 570 SSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSI-PFRGKFYKW 628
SR C++P P GG+ CLG ++ CN+++CP +DFR QC++ +S + + W
Sbjct: 578 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSW 637
Query: 629 KTYR-GGGVKACSLTCLAEGFNFYTERAAAVVDGTPCR-PDTVDICVSGECKHVGCDRVL 686
Y + C L C + V DGT C D +C GEC VGCD+ +
Sbjct: 638 VPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEV 697
Query: 687 GSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHL 746
GS +DKC VCGGD S C T++G AS AG +V IP G+ HI I+ L S +
Sbjct: 698 GSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRI 757
Query: 747 ALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLART 806
+K + G R A D +SL+ GP+ ++ ++ L T
Sbjct: 758 VVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPT 817
Query: 807 EL-PALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHY 865
E P + I D LP G + V E
Sbjct: 818 EGGPRSSLAYKYVIHEDLLP---------------LIGSNNVLLEEMDTY---------- 852
Query: 866 CSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDD 925
+W + +W+ CS++C G++ C+RR + +
Sbjct: 853 ---------------------EWALKSWAPCSKACGGGIQFTKYGCRRR---RDHHMVQR 888
Query: 926 SACP-QPRP-PVLEACHGPTCP-PEWAALDWSECTPSCGP-GLRHRVVLCKSADHRAT-- 979
C + RP P+ C+ C P W +W C+ SCG G++ R + C T
Sbjct: 889 HLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHK 948
Query: 980 LPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASH 1039
+ PA +P A C LR PA+W G W +CSA CG G +QR V C ++ H
Sbjct: 949 VMPAKACAGDRPEARRPC-LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH 1007
Query: 1040 ECTEALRPPTTQQCEAKC------DSPTPGD-------------GPEECKDVNKVA---- 1076
E RP T Q C +S D E +NK++
Sbjct: 1008 --CEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEP 1065
Query: 1077 -------YCPLVLKFQFCSRAYFRQMCCKTC 1100
+C + + ++CS + ++CC +C
Sbjct: 1066 CTGDRSVFCQMEVLDRYCSIPGYHRLCCVSC 1096
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 431 bits (1107), Expect = e-120
Identities = 331/1111 (29%), Positives = 477/1111 (42%), Gaps = 145/1111 (13%)
Query: 44 PTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVS 103
PT H+ L P G L++ V L L + RL+ S
Sbjct: 74 PTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSS 133
Query: 104 VEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHG 163
VE+ +++ R C+Y G + G + VAIS C GL GLI D ++ IEPL
Sbjct: 134 VEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE- 191
Query: 164 GPKGSRSPEESG-PHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGN 222
+G + E SG HVVY+R +++ + + +E G L L LG+
Sbjct: 192 --RGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGD---LPNLLGLVGDQLGD 246
Query: 223 ETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGS 282
+ + S S +E L+V D +V +HG+ V+ YVL +MNIV +++ D SLG
Sbjct: 247 TERKRRHAKPGSYS----IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGV 302
Query: 283 TVNILVTRLILLTEDQPTLEITH-HAGKSLDSFCKW----QKSIVNHSGHGNAIPENGVA 337
+NI + RLI++ Q I + +SL+ C+W Q+ +H+ H
Sbjct: 303 HINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEH---------- 352
Query: 338 NHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHT 397
HD V +TR D G G APV GMC RSC++N + G ++AF IAHE GH
Sbjct: 353 -HDHVVFLTRQDF--------GPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHV 403
Query: 398 FGMNHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
GM HDG GN C A +MA + + F WS CS+ ++ +L S CL + P
Sbjct: 404 LGMEHDGQGNGC-ADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYD--CLLDDP 460
Query: 458 PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC---KYGEVCSELWCLSKSNR--CITNS 512
+ P PG Y DEQCRF G + C + E C +LWC N C T
Sbjct: 461 FDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKK 520
Query: 513 IPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE---GVDGAWGPWTPWGDCSRTCGGGVSS 569
P +GT C WC+K C+ PE G DG W WT +G CSR+CGGGV S
Sbjct: 521 GPPLDGTECAPGK----WCFKGHCI--WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 574
Query: 570 SSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSI-PFRGKFYKW 628
SR C++P P GG+ CLG ++ CN+++CP +DFR QC++ +S + + W
Sbjct: 575 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSW 634
Query: 629 KTYR-GGGVKACSLTCLAEGFNFYTERAAAVVDGTPCR-PDTVDICVSGECKHVGCDRVL 686
Y + C L C + V DGT C D +C GEC VGCD+ +
Sbjct: 635 VPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEV 694
Query: 687 GSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHL 746
GS +DKC VCGGD S C T++G AS AG +V IP G+ HI I+ L S +
Sbjct: 695 GSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRI 754
Query: 747 ALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLART 806
+K + G R A D +SL+ GP+ ++ ++ L T
Sbjct: 755 VVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPT 814
Query: 807 EL-PALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHY 865
E P + I D LP G + V E
Sbjct: 815 EGGPRSSLAYKYVIHEDLLP---------------LIGSNNVLLEEMDTY---------- 849
Query: 866 CSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDD 925
+W + +W+ CS++C G++ C+RR + +
Sbjct: 850 ---------------------EWALKSWAPCSKACGGGIQFTKYGCRRR---RDHHMVQR 885
Query: 926 SACP-QPRP-PVLEACHGPTCP-PEWAALDWSECTPSCGP-GLRHRVVLCKSADHRAT-- 979
C + RP P+ C+ C P W +W C+ SCG G++ R + C T
Sbjct: 886 HLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHK 945
Query: 980 LPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASH 1039
+ PA +P A C LR PA+W G W +CSA CG G +QR V C ++ H
Sbjct: 946 VMPAKACAGDRPEARRPC-LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH 1004
Query: 1040 ECTEALRPPTTQQCEAKC------DSPTPGD-------------GPEECKDVNKVA---- 1076
E RP T Q C +S D E +NK++
Sbjct: 1005 --CEGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEP 1062
Query: 1077 -------YCPLVLKFQFCSRAYFRQMCCKTC 1100
+C + + ++CS + ++CC +C
Sbjct: 1063 CTGDRSVFCQMEVLDRYCSIPGYHRLCCVSC 1093
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 402 bits (1032), Expect = e-111
Identities = 281/863 (32%), Positives = 423/863 (49%), Gaps = 102/863 (11%)
Query: 87 FLLNLTRSSRLLAGHVSVEYWTREGLAW--QRAARPHCLYAGHLQGQASTSHVAISTCGG 144
F+L L LA +E G A +R R C ++G + G+ S A+S C G
Sbjct: 64 FVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRG-CFFSGTVNGEPE-SLAAVSLCRG 121
Query: 145 LHGLIVADEEEYLIEPLHGG-------------PKGSRSPEESGPHVVYK----RSSLRH 187
L G + D EE+ I+P G P G+R P GP + + R
Sbjct: 122 LSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGAR-PLPRGPEWEVETGEGQRQERG 180
Query: 188 PHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVA 247
H + + E+ +G +PPP PLG + KR VS R+VETL+VA
Sbjct: 181 DHQEDSEEESQEEEAEGAS------EPPP--PLGATSRT-----KRFVSEARFVETLLVA 227
Query: 248 DKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHA 307
D M A++G D++ ++L +M++ A++++ S+ +++N++V +++++ +++ E++ +
Sbjct: 228 DASMAAFYGA-DLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNG 286
Query: 308 GKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVG 367
G +L +FC WQ+ N + ++DTA+L+TR + C + C TLG+A +G
Sbjct: 287 GLTLRNFCNWQRRF-------NQPSDRHPEHYDTAILLTRQNFCGQEGL-CDTLGVADIG 338
Query: 368 GMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSC----GARGQDPAKLMAAH 423
+C+ +SCSV ED GL A T+AHE+GH M HD C G G+ +MA
Sbjct: 339 TICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDD-SKPCTRLFGPMGKH--HVMAPL 395
Query: 424 ITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQA--YDADEQCRF 481
WS CS Y+T LD G G CL + P PT PG+ Y D+QCR
Sbjct: 396 FVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAA-LPLPTGLPGRMALYQLDQQCRQ 454
Query: 482 QHGVKSRQC---KYGEVCSELWCLSKSNR--CITN--SIPAAEGTLCQT-HTIDKGWCYK 533
G R C +VC++LWC + C T S+P A+GT C H +G C
Sbjct: 455 IFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLP 514
Query: 534 RVCVPFGSRPEGV-DGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRR 592
V RP+ V DG W PW PWG+CSRTCGGGV S R C P P GG+YCLG R +
Sbjct: 515 EEEV---ERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAK 571
Query: 593 HRSCNTDDCPPGSQDFREVQCSEFDSIPFR---GKFYKW-KTYRGGGVK-ACSLTCLAEG 647
++SC+T++CPP + FRE QC ++++ + G +W Y G + C L C A G
Sbjct: 572 YQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARG 631
Query: 648 FNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACET 707
+ + A V+DGT C P+T+ ICV G+C GCD V+ S + DKC VCGG G++C
Sbjct: 632 RSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRK 691
Query: 708 IEGVFSPASPGAGYEDVVWIPKGSVHIFIQD-----LNLSLSHLALK-GDQESLLLEGLP 761
+ G +P + GY D+V IP G+ +I ++ + ++LALK D + LL L
Sbjct: 692 VSGSLTPTN--YGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLA 749
Query: 762 GTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVL---ARTELPALRYRFNAP 818
+ + + GT + ++ L++ P+ L V +L P ++Y F P
Sbjct: 750 ISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVP 809
Query: 819 IARD----------------SLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVA 862
D L W W++CS+ C G Q + VECR D S A
Sbjct: 810 NDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECR---DPSGQA 866
Query: 863 PHYCSAHSKLPKRQRACNTEPCP 885
C+ K P+ + C ++ CP
Sbjct: 867 SATCNKALK-PEDAKPCESQLCP 888
Score = 62.8 bits (151), Expect = 2e-09
Identities = 24/52 (46%), Positives = 36/52 (69%)
Query: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAK 1056
A+WV G+W ECS+ CG G ++R+V C +GQAS C +AL+P + CE++
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQ 885
Score = 48.1 bits (113), Expect = 4e-05
Identities = 22/62 (35%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 942 PTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRR 1001
P +W DWSEC+ +CG G + R V C+ +A+ A C+ A KP C +
Sbjct: 830 PLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQAS---ATCNKALKPEDAKPCESQL 886
Query: 1002 CP 1003
CP
Sbjct: 887 CP 888
Score = 35.0 bits (79), Expect = 0.39
Identities = 23/94 (24%), Positives = 36/94 (38%), Gaps = 7/94 (7%)
Query: 864 HYCSAHSKLPKRQRACNTEPCPPDWVV-GNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKA 922
H CS S LP+ + W G W CSR+C GV+ C+ + +
Sbjct: 505 HLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECK------DPEP 558
Query: 923 LDDSACPQPRPPVLEACHGPTCPPEWAALDWSEC 956
+ R ++CH CPP+ + +C
Sbjct: 559 QNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQC 592
Score = 31.6 bits (70), Expect = 4.3
Identities = 28/81 (34%), Positives = 33/81 (40%), Gaps = 19/81 (23%)
Query: 942 PTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRR 1001
P C + +L W++ TP CGPG LC + LP KP A
Sbjct: 484 PLCHTKNGSLPWADGTP-CGPGH-----LCSEG---SCLPEEEVE-RPKPVADGGW---- 529
Query: 1002 CPPARWVAGEWGECSAQCGVG 1022
A W G WGECS CG G
Sbjct: 530 ---APW--GPWGECSRTCGGG 545
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 399 bits (1026), Expect = e-111
Identities = 289/912 (31%), Positives = 414/912 (45%), Gaps = 126/912 (13%)
Query: 58 PPPPRRQRRGTGATAE--------SRLFYKVASPSTHFLLNLTRSSRL-LAGHVSVEYWT 108
P P ++RR G ++ Y V + FLL+L R + +AG V T
Sbjct: 61 PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT 120
Query: 109 REGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGS 168
W+ R HC Y G + G + S CGGL G Y ++PL GP
Sbjct: 121 --SAPWRH--RSHCFYRGTVDG-SPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAE 175
Query: 169 RSPEESGPHVVYKRSSLRHPHLDTACG--------------------VRDEKPWKGRPWW 208
EE G VY S R H+ T G + P P
Sbjct: 176 ---EEKGR--VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSG 230
Query: 209 LRTLKPP--------PARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDV 260
L PA G +T + +RS+SR R VE L+VAD M +GR +
Sbjct: 231 RAALASQLLDQSALSPAGGSGPQTWWRRR--RRSISRARQVELLLVADASMARLYGR-GL 287
Query: 261 EQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKS 320
+ Y+L + +I +L+ +S+ + + + V ++++L + +LE++ +A +L +FCKWQ
Sbjct: 288 QHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQ 347
Query: 321 IVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNE 380
N + ++ ++D A+L TR D+C + + C TLG+A VG +C ERSC+V E
Sbjct: 348 -------HNQLGDDHEEHYDAAILFTREDLCGHHS--CDTLGMADVGTICSPERSCAVIE 398
Query: 381 DIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQ-DPAKLMAAHITMKTNPFVWSSCSRD 439
D GL AFT+AHEIGH G++HD G + +LM++ +T WS C+
Sbjct: 399 DDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSA 458
Query: 440 YITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSEL 499
IT FLD G G CL + P R+ + P PGQ YDA +QC G + C +VC+ L
Sbjct: 459 TITEFLDDGHGNCLLDLP-RKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARL 517
Query: 500 WCLSKSNR---CITNSIPAAEGTLCQTHTID-KGWCYKRVCVPFGSRPEGVDGAWGPWTP 555
WC C+T +PA EGT C I +G C + + S G WG W
Sbjct: 518 WCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSS--HGNWGSWGS 575
Query: 556 WGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSE 615
WG CSR+CGGGV + RHC++P P G+YC G+R +RSC+ CPP + FR QC
Sbjct: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEA 635
Query: 616 FDSIPFRGK----FYKWKTYRGGGVKA--CSLTCLAEGFNFYTERAAAVVDGTPCRPDTV 669
+ K F +W G + A C LTC A+G +Y + V DGT CR +
Sbjct: 636 KNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSN 695
Query: 670 DICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPK 729
+CV G+C GCD ++GS L+ DKC VCGGD S+C I G F+ S G Y DVV IP+
Sbjct: 696 SVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKG--YTDVVRIPE 753
Query: 730 GSVHIFIQ-----DLNLSLSHLALKGDQESLLLEG--LPGTPQPHRLPLAGTTFQLRQGP 782
G+ HI ++ D ++LALK L+ G + T + + + GT
Sbjct: 754 GATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETI-IDINGTVMNYSGWS 812
Query: 783 DQVQSLEALG--PINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQ 840
+ L +G LIV +LA L R++ + + S P + S
Sbjct: 813 HRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVN---------SVT 863
Query: 841 CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC 900
G ++V + P WV G W CSR+C
Sbjct: 864 SHGSNKV--------------------------------GSHTSQPQWVTGPWLACSRTC 891
Query: 901 DAGVRSRSVVCQ 912
D G +R+V CQ
Sbjct: 892 DTGWHTRTVQCQ 903
Score = 39.7 bits (91), Expect = 0.016
Identities = 17/51 (33%), Positives = 24/51 (47%)
Query: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAK 1056
+WV G W CS C G R+V+C + + C + RP +QC K
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLK 928
Score = 37.0 bits (84), Expect = 0.10
Identities = 16/60 (26%), Positives = 27/60 (45%), Gaps = 3/60 (5%)
Query: 943 TCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRC 1002
T P+W W C+ +C G R V C+ + + C + +P A +C L++C
Sbjct: 874 TSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLA---KGCPLSQRPSAFKQCLLKKC 930
Score = 31.2 bits (69), Expect = 5.7
Identities = 31/135 (22%), Positives = 52/135 (38%), Gaps = 17/135 (12%)
Query: 879 CNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEA 938
CN P V +C+R A VR +VC + + A++ + C + R +
Sbjct: 497 CNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTK----KLPAVEGTPCGKGRICLQGK 552
Query: 939 C--------HGPTCPPEWAAL-DWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAA 989
C + + W + W +C+ SCG G++ C + R +C+
Sbjct: 553 CVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNN--GRYCT--G 608
Query: 990 KPPATMRCNLRRCPP 1004
K C+L CPP
Sbjct: 609 KRAIYRSCSLMPCPP 623
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 399 bits (1025), Expect = e-111
Identities = 286/816 (35%), Positives = 390/816 (47%), Gaps = 84/816 (10%)
Query: 40 EIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLA 99
EI FP ++ NG++L G+ A +RL ++ + LL L + S +
Sbjct: 60 EIVFPEKL--NGSVLP-------------GSGAPARLLCRLQAFGETLLLELEQDSGVQV 104
Query: 100 GHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIE 159
++V+Y + A P G + G + G L G++ E ++
Sbjct: 105 EGLTVQY-LGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQ 163
Query: 160 PLHGG-PKGSRSPEESGPHVVYKRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPAR 218
PL GG P + P G H++ ++S C V+
Sbjct: 164 PLEGGTPNSAGGP---GAHILRRKSPASGQ--GPMCNVK--------------------A 198
Query: 219 PLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDS 278
PLG+ + R + KR S R+VETLVVAD M A+HG +++Y+L +M AK F+
Sbjct: 199 PLGSPSPRPRRA-KRFASLSRFVETLVVADDKMAAFHGA-GLKRYLLTVMAAAAKAFKHP 256
Query: 279 SLGSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVAN 338
S+ + V+++VTRL++L + ++ A ++L SFC WQ+ G PE+ +
Sbjct: 257 SIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR--------GLNTPEDSDPD 308
Query: 339 H-DTAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHT 397
H DTA+L TR D+C C TLG+A VG +C+ RSC++ ED GL +AFT AHE+GH
Sbjct: 309 HFDTAILFTRQDLCGVST--CDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHV 366
Query: 398 FGMNHDGVGNSCGARGQ-DPAKLMAAHITMKTNPFV-WSSCSRDYITSFLDSGLGLCLNN 455
F M HD G ++ + A + +P WS CS +IT FLD+G G CL +
Sbjct: 367 FNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLD 426
Query: 456 RPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC-KYGEVCSELWCLSKSN---RCITN 511
+P P PG+ YDAD QC+ G SR C + C+ LWC N C T
Sbjct: 427 KP-EAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTK 485
Query: 512 SIPAAEGTLC-QTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSS 570
P A+GT C G C + + P+ G WGPW PWGDCSRTCGGGV S
Sbjct: 486 HSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQA--GGWGPWGPWGDCSRTCGGGVQFS 543
Query: 571 SRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQ-DFREVQCSEFDS-----IPFRGK 624
SR C P P GGKYC G R R RSCNT+DCP GS FRE QC+ ++ F G
Sbjct: 544 SRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGP 603
Query: 625 FYKWKTYRGGGVK-ACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCD 683
Y G + C LTC A+ +Y VVDGTPC PD+ +CV G C H GCD
Sbjct: 604 MDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCD 663
Query: 684 RVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQ---DLN 740
R++GS + DKC VCGGDGS C G F GY +VV IP G+ HI ++ +
Sbjct: 664 RIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR--YGYNNVVTIPAGATHILVRQQGNPG 721
Query: 741 LSLSHLALKGDQESLLLEG-LPGTPQPHRLPLAGTTFQLRQGPDQV-QSLEALGPI--NA 796
+LALK S L G P P + L G G ++L GP+
Sbjct: 722 HRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPL 781
Query: 797 SLIVMVLARTELPALRYRFNAPIARDSLP---PYSW 829
+L V+V + LRY F P S P P W
Sbjct: 782 TLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDW 817
Score = 39.3 bits (90), Expect = 0.021
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 5/55 (9%)
Query: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCP 885
+ PW CS C GG Q + +C + + YC R R+CNTE CP
Sbjct: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRN--GGKYCEGRR---TRFRSCNTEDCP 575
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 351 bits (900), Expect = 2e-96
Identities = 195/529 (36%), Positives = 261/529 (49%), Gaps = 49/529 (9%)
Query: 550 WGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFR 609
WGPW+ W CSRTCGGGVS R C S R GG C+G R HRSC T+ CP G++DFR
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 610 EVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTV 669
QC+EFD F+G+ Y+W Y K C L C+ +G NFY + AVVDGTPC P
Sbjct: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNK-CELNCIPKGENFYYKHREAVVDGTPCEPGKR 146
Query: 670 DICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPK 729
D+CV G C+ VGCD L S +EDKC CGGDG+ C + G F
Sbjct: 147 DVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA--------------- 191
Query: 730 GSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPD---QVQ 786
DL+ A+K + L G LP A T +G + +
Sbjct: 192 -------NDLSR-----AVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPE 239
Query: 787 SLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQ 846
L A GP + L++ ++++ P + Y ++ P+ R S P +SW + W+ CSA+C GG Q
Sbjct: 240 RLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPS-PGFSWSHGSWSDCSAECGGGHQ 298
Query: 847 VQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPD--WVVGNWSLCSRSCDAGV 904
+ V C +D A H C + P +R+CN PCP W G W+ CS SC G
Sbjct: 299 SRLVFCT--IDHEAYPDHMCQRQPR-PADRRSCNLHPCPETKRWKAGPWAPCSASCGGGS 355
Query: 905 RSRSVVCQRRVSAAEEKALDDSACP--QPRPPVLEACHGPTCPPEWAALDWSECTPSCGP 962
+SRSV C A ++A++++ C +PP ++AC+ C W+ W EC+ SCG
Sbjct: 356 QSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA-WSPEPWGECSVSCGV 414
Query: 963 GLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP---PARWVAGEWGECSAQC 1019
G+R R V C+ + + L A CS +PP T C CP W G WG CS C
Sbjct: 415 GVRKRSVTCRG-ERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSC 473
Query: 1020 GVGQRQRSVRCT----SHTGQASHECTEALRPPTTQQCEAKCDSPTPGD 1064
G R+R V C SH G H + P TQ C + P+ D
Sbjct: 474 SSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQD 522
Score = 40.8 bits (94), Expect = 0.007
Identities = 16/64 (25%), Positives = 33/64 (51%)
Query: 1037 ASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMC 1096
++++ ++A+ T + + + P D +C D ++A C L+L+ Q C Y+ C
Sbjct: 1176 SAYQGSQAVSRSTEVKVVSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFC 1235
Query: 1097 CKTC 1100
C +C
Sbjct: 1236 CASC 1239
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 346 bits (887), Expect = 8e-95
Identities = 264/885 (29%), Positives = 373/885 (42%), Gaps = 95/885 (10%)
Query: 229 PGLKRSVSRER-------YVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLG 281
PG +R R+R ++E LV + H + D E+YVL +NI A+L +D SLG
Sbjct: 63 PGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLG 121
Query: 282 STVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDT 341
+ + + ++++LTE + IT + SL S C W ++I N + + D
Sbjct: 122 AQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTI-------NPEDDTDPGHADL 174
Query: 342 AVLITRYDICIYKNKPCGTL---GLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTF 398
+ ITR+D+ + P G G+ +GG C SC + ED G TIAHEIGH+F
Sbjct: 175 VLYITRFDLEL----PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSF 230
Query: 399 GMNHDGV-GNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
G+ HDG G+ CG G +MA+ WS CSR + S L +G C+ + P
Sbjct: 231 GLEHDGAPGSGCGPSGH----VMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPP 286
Query: 458 ---PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYG----EVCSELWCLSK---SNR 507
P P PG Y A+EQCR G K+ C + ++C L C + +
Sbjct: 287 RPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSS 346
Query: 508 CITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE--GVDGAWGPWTPWGDCSRTCGG 565
C +P +GT C WC K C V G W W P CSR+CGG
Sbjct: 347 CSRLLVPLLDGTECGVEK----WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGG 402
Query: 566 GVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFR--- 622
GV + R C++PRP GG+ C+G + CNT C +F QC+ D P R
Sbjct: 403 GVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSP 462
Query: 623 --GKFYKW--KTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPD------TVDIC 672
FY W G C C A G +F +R + +DGT C P T+ +C
Sbjct: 463 GGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLC 522
Query: 673 VSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSV 732
VSG C+ GCD + S D+C+VCGGD S C +G F+ A Y + +
Sbjct: 523 VSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLT 581
Query: 733 HIFIQDLNLSLSHLALKGDQESLLLEGL---PGTPQPHRLPLAGTTFQLRQGPDQVQSLE 789
++I + +HLA++ ++ + P T P L +++ D++ LE
Sbjct: 582 SVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLE 641
Query: 790 AL---GPINASLIVMVLAR-------TELPALRYRFNAPIARDSLPPYSWHYAPWT-KCS 838
+ GP+ + V R P + + + P P +W +A CS
Sbjct: 642 EIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQP-----KPRQAWVWAAVRGPCS 696
Query: 839 AQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSR 898
C G + C +Q V C + P AC EPCPP W VG++ CS
Sbjct: 697 VSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSA 756
Query: 899 SCDAGVRSRSVVCQRRVSAAEEKALDDSAC---PQPRPPVLEACHGPTCPPEWAALDWSE 955
SC G+R R V C + K L + C Q LE C+ CP W + S
Sbjct: 757 SCGGGLRERPVRCV-EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
Query: 956 CTPSCGPGLRHRVVLC-KSADH-RATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWG 1013
CT + G GL C AD A + S K PA C CPP WG
Sbjct: 816 CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG------WG 869
Query: 1014 ECSAQCGVGQRQRSVRCTSHTG-QASHECTEALRPPTTQQCEAKC 1057
A G++ S + TG QA+H T P C C
Sbjct: 870 HLDA-TSAGEKAPSPWGSIRTGAQAAHVWT-----PAAGSCSVSC 908
Score = 112 bits (280), Expect = 2e-24
Identities = 77/243 (31%), Positives = 94/243 (38%), Gaps = 16/243 (6%)
Query: 834 WT----KCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWV 889
WT CS C G C + V C SK R+ C PCP W
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQ 956
Query: 890 VGNWSLCSRSCDAGVRSRSVVCQRRVSA--AEEKALDDSACPQPRPPVLEACHGPTCPPE 947
+ CS SC GV R + C R EE LD PRP EAC CPP
Sbjct: 957 Y-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 1015
Query: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHR--ATLPPAHCSPAAKPPATMRCNLRRCPPA 1005
W + C+ SCG G R V C D + A C+ +P A++ C + C
Sbjct: 1016 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT-Y 1074
Query: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA---SHECTEALRPPTTQQCEAKCDSPTP 1062
RW G W ECS CG G ++R C QA + C +P T + C A P
Sbjct: 1075 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWA---GPCV 1131
Query: 1063 GDG 1065
G G
Sbjct: 1132 GQG 1134
Score = 85.1 bits (209), Expect = 3e-16
Identities = 52/176 (29%), Positives = 71/176 (40%), Gaps = 6/176 (3%)
Query: 826 PYSWHYAPWTKCSAQCAGGSQVQAVEC---RNQLDSSAVAPHYCSAHSKLPKRQRACNTE 882
P W Y CS C G + + C + D + P+ Q AC+ E
Sbjct: 952 PARWQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 1010
Query: 883 PCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEACHG 941
PCPP W V + CS SC G RSV C ++ ++ +D++AC RP C
Sbjct: 1011 PCPPRWKVMSLGPCSASCGLGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLI 1069
Query: 942 PTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC 997
C W W EC+ SCG G++ R C +A +P C KP C
Sbjct: 1070 ADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1125
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 346 bits (887), Expect = 8e-95
Identities = 264/885 (29%), Positives = 373/885 (42%), Gaps = 95/885 (10%)
Query: 229 PGLKRSVSRER-------YVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLG 281
PG +R R+R ++E LV + H + D E+YVL +NI A+L +D SLG
Sbjct: 63 PGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLG 121
Query: 282 STVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDT 341
+ + + ++++LTE + IT + SL S C W ++I N + + D
Sbjct: 122 AQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTI-------NPEDDTDPGHADL 174
Query: 342 AVLITRYDICIYKNKPCGTL---GLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTF 398
+ ITR+D+ + P G G+ +GG C SC + ED G TIAHEIGH+F
Sbjct: 175 VLYITRFDLEL----PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSF 230
Query: 399 GMNHDGV-GNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
G+ HDG G+ CG G +MA+ WS CSR + S L +G C+ + P
Sbjct: 231 GLEHDGAPGSGCGPSGH----VMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPP 286
Query: 458 ---PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYG----EVCSELWCLSK---SNR 507
P P PG Y A+EQCR G K+ C + ++C L C + +
Sbjct: 287 RPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSS 346
Query: 508 CITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPE--GVDGAWGPWTPWGDCSRTCGG 565
C +P +GT C WC K C V G W W P CSR+CGG
Sbjct: 347 CSRLLVPLLDGTECGVEK----WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGG 402
Query: 566 GVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFR--- 622
GV + R C++PRP GG+ C+G + CNT C +F QC+ D P R
Sbjct: 403 GVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSP 462
Query: 623 --GKFYKW--KTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPD------TVDIC 672
FY W G C C A G +F +R + +DGT C P T+ +C
Sbjct: 463 GGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLC 522
Query: 673 VSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSV 732
VSG C+ GCD + S D+C+VCGGD S C +G F+ A Y + +
Sbjct: 523 VSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLT 581
Query: 733 HIFIQDLNLSLSHLALKGDQESLLLEGL---PGTPQPHRLPLAGTTFQLRQGPDQVQSLE 789
++I + +HLA++ ++ + P T P L +++ D++ LE
Sbjct: 582 SVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLE 641
Query: 790 AL---GPINASLIVMVLAR-------TELPALRYRFNAPIARDSLPPYSWHYAPWT-KCS 838
+ GP+ + V R P + + + P P +W +A CS
Sbjct: 642 EIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQP-----KPRQAWVWAAVRGPCS 696
Query: 839 AQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSR 898
C G + C +Q V C + P AC EPCPP W VG++ CS
Sbjct: 697 VSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSA 756
Query: 899 SCDAGVRSRSVVCQRRVSAAEEKALDDSAC---PQPRPPVLEACHGPTCPPEWAALDWSE 955
SC G+R R V C + K L + C Q LE C+ CP W + S
Sbjct: 757 SCGGGLRERPVRCV-EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
Query: 956 CTPSCGPGLRHRVVLC-KSADH-RATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWG 1013
CT + G GL C AD A + S K PA C CPP WG
Sbjct: 816 CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG------WG 869
Query: 1014 ECSAQCGVGQRQRSVRCTSHTG-QASHECTEALRPPTTQQCEAKC 1057
A G++ S + TG QA+H T P C C
Sbjct: 870 HLDA-TSAGEKAPSPWGSIRTGAQAAHVWT-----PAAGSCSVSC 908
Score = 112 bits (280), Expect = 2e-24
Identities = 77/243 (31%), Positives = 94/243 (38%), Gaps = 16/243 (6%)
Query: 834 WT----KCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWV 889
WT CS C G C + V C SK R+ C PCP W
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQ 956
Query: 890 VGNWSLCSRSCDAGVRSRSVVCQRRVSA--AEEKALDDSACPQPRPPVLEACHGPTCPPE 947
+ CS SC GV R + C R EE LD PRP EAC CPP
Sbjct: 957 Y-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 1015
Query: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHR--ATLPPAHCSPAAKPPATMRCNLRRCPPA 1005
W + C+ SCG G R V C D + A C+ +P A++ C + C
Sbjct: 1016 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT-Y 1074
Query: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA---SHECTEALRPPTTQQCEAKCDSPTP 1062
RW G W ECS CG G ++R C QA + C +P T + C A P
Sbjct: 1075 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWA---GPCV 1131
Query: 1063 GDG 1065
G G
Sbjct: 1132 GQG 1134
Score = 85.1 bits (209), Expect = 3e-16
Identities = 52/176 (29%), Positives = 71/176 (40%), Gaps = 6/176 (3%)
Query: 826 PYSWHYAPWTKCSAQCAGGSQVQAVEC---RNQLDSSAVAPHYCSAHSKLPKRQRACNTE 882
P W Y CS C G + + C + D + P+ Q AC+ E
Sbjct: 952 PARWQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 1010
Query: 883 PCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEACHG 941
PCPP W V + CS SC G RSV C ++ ++ +D++AC RP C
Sbjct: 1011 PCPPRWKVMSLGPCSASCGLGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLI 1069
Query: 942 PTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC 997
C W W EC+ SCG G++ R C +A +P C KP C
Sbjct: 1070 ADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1125
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 325 bits (832), Expect = 2e-88
Identities = 256/882 (29%), Positives = 363/882 (41%), Gaps = 120/882 (13%)
Query: 229 PGLKRSVSRER-------YVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLG 281
PG +R R+R ++E LV + H + D E+YVL +NI A+L +D SLG
Sbjct: 63 PGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLG 121
Query: 282 STVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDT 341
+ + + ++++LTE + IT + SL S C W ++I N + + D
Sbjct: 122 AQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTI-------NPEDDTDPGHADL 174
Query: 342 AVLITRYDICIYKNKPCGTL---GLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTF 398
+ ITR+D+ + P G G+ +GG C SC + ED G TIAHEIGH+F
Sbjct: 175 VLYITRFDLEL----PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSF 230
Query: 399 GMNHDGV-GNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
G+ HDG G+ CG G +MA+ WS CSR + S L
Sbjct: 231 GLEHDGAPGSGCGPSGH----VMASDGAAPRAGLAWSPCSRRQLLSLL------------ 274
Query: 458 PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYG----EVCSELWCLS---KSNRCIT 510
A+EQCR G K+ C + ++C L C + + C
Sbjct: 275 ----------------SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSR 318
Query: 511 NSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRP--EGVDGAWGPWTPWGDCSRTCGGGVS 568
+P +GT C + WC K C V G W W P CSR+CGGGV
Sbjct: 319 LLVPLLDGTECGV----EKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVV 374
Query: 569 SSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFR-----G 623
+ R C++PRP GG+ C+G + CNT C +F QC+ D P R
Sbjct: 375 TRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGA 434
Query: 624 KFYKW--KTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPD------TVDICVSG 675
FY W G C C A G +F +R + +DGT C P T+ +CVSG
Sbjct: 435 SFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSG 494
Query: 676 ECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIF 735
C+ GCD + S D+C+VCGGD S C +G F+ A Y + + ++
Sbjct: 495 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVY 553
Query: 736 IQDLNLSLSHLALKGDQESLLLEGL---PGTPQPHRLPLAGTTFQLRQGPDQVQSLEAL- 791
I + +HLA++ ++ + P T P L +++ D++ LE +
Sbjct: 554 IANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIR 613
Query: 792 --GPINASLIVMVLAR-------TELPALRYRFNAPIARDSLPPYSWHYAPWT-KCSAQC 841
GP+ + V R P + + + P P +W +A CS C
Sbjct: 614 IWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQP-----KPRQAWVWAAVRGPCSVSC 668
Query: 842 AGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCD 901
G + C +Q V C + P AC EPCPP W VG++ CS SC
Sbjct: 669 GAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG 728
Query: 902 AGVRSRSVVCQRRVSAAEEKALDDSAC---PQPRPPVLEACHGPTCPPEWAALDWSECTP 958
G+R R V C + K L + C Q LE C+ CP W + S CT
Sbjct: 729 GGLRERPVRCV-EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTS 787
Query: 959 SCGPGLRHRVVLC-KSADH-RATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECS 1016
+ G GL C AD A + S K PA C CPP WG
Sbjct: 788 AGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG------WGHLD 841
Query: 1017 AQCGVGQRQRSVRCTSHTG-QASHECTEALRPPTTQQCEAKC 1057
A G++ S + TG QA+H T P C C
Sbjct: 842 A-TSAGEKAPSPWGSIRTGAQAAHVWT-----PAAGSCSVSC 877
Score = 112 bits (280), Expect = 2e-24
Identities = 77/243 (31%), Positives = 94/243 (38%), Gaps = 16/243 (6%)
Query: 834 WT----KCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWV 889
WT CS C G C + V C SK R+ C PCP W
Sbjct: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQ 925
Query: 890 VGNWSLCSRSCDAGVRSRSVVCQRRVSA--AEEKALDDSACPQPRPPVLEACHGPTCPPE 947
+ CS SC GV R + C R EE LD PRP EAC CPP
Sbjct: 926 Y-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 984
Query: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHR--ATLPPAHCSPAAKPPATMRCNLRRCPPA 1005
W + C+ SCG G R V C D + A C+ +P A++ C + C
Sbjct: 985 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT-Y 1043
Query: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA---SHECTEALRPPTTQQCEAKCDSPTP 1062
RW G W ECS CG G ++R C QA + C +P T + C A P
Sbjct: 1044 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWA---GPCV 1100
Query: 1063 GDG 1065
G G
Sbjct: 1101 GQG 1103
Score = 85.1 bits (209), Expect = 3e-16
Identities = 52/176 (29%), Positives = 71/176 (40%), Gaps = 6/176 (3%)
Query: 826 PYSWHYAPWTKCSAQCAGGSQVQAVEC---RNQLDSSAVAPHYCSAHSKLPKRQRACNTE 882
P W Y CS C G + + C + D + P+ Q AC+ E
Sbjct: 921 PARWQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 979
Query: 883 PCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEACHG 941
PCPP W V + CS SC G RSV C ++ ++ +D++AC RP C
Sbjct: 980 PCPPRWKVMSLGPCSASCGLGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLI 1038
Query: 942 PTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC 997
C W W EC+ SCG G++ R C +A +P C KP C
Sbjct: 1039 ADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1094
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 292 bits (748), Expect = 1e-78
Identities = 195/594 (32%), Positives = 268/594 (45%), Gaps = 98/594 (16%)
Query: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPP 603
E DG W W PW +CSRTCGGG S S R C + K C G R+R+C+ DCPP
Sbjct: 30 EDRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPP 83
Query: 604 GSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTP 663
+ DFR QCS + + G+FY+W CSL C A+G E A V+DGT
Sbjct: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
Query: 664 CRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVF-SPASPGAGYE 722
C +++D+C+SG C+ VGCD LGS ++ED C VC GDGS C + G + S S +
Sbjct: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDD 203
Query: 723 DVVWIPKGSVHIFIQDLNLSLSHLALKG-DQESLLLEGLPGTPQPHRLPLAGT------T 775
VV IP GS HI L LKG D L + L GT + L GT +
Sbjct: 204 TVVAIPYGSRHI----------RLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSS 253
Query: 776 FQLRQGPDQVQSLEALGPINASLIVMVL-ARTELPALRYRFNAPIARDSLPPYSWHYAPW 834
++ PD+ + L GP+ A IV + + + +++ F PI + W +
Sbjct: 254 VDFQKFPDK-EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII------HRWRETDF 306
Query: 835 TKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSK----LPKRQRACNTEPCP----- 885
CSA C GG Q+ + EC + + VA YC + + PK Q CN +PCP
Sbjct: 307 FPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNLDPCPASDGY 365
Query: 886 ------------PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPR 932
P W W+ CS SC G++SR+V C ++++ C P+
Sbjct: 366 KQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPK 425
Query: 933 PPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP 992
P+ + C+ C P+W A +WS CT +CG GLR+RVVLC DHR + CSP KP
Sbjct: 426 MPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLC--IDHRG-MHTGGCSPKTKPH 481
Query: 993 ATMRCNL--------RRCP----------------------PARWVAGEWGECSAQCGVG 1022
C + + P ++ W C+ CGVG
Sbjct: 482 IKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVG 541
Query: 1023 QRQRSVRC-------TSHTGQASHECTEALRPPTTQQCEA-KCDSPTPGDGPEE 1068
+ R VRC S EC E +P + + C A C P P+E
Sbjct: 542 TQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCSGEIPEFNPDE 594
Score = 163 bits (412), Expect = 1e-39
Identities = 79/209 (37%), Positives = 106/209 (50%), Gaps = 7/209 (3%)
Query: 827 YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886
Y W Y +TKCS C GG Q V C N+ + C + P+ ++CN +PCP
Sbjct: 609 YDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA 668
Query: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAA--EEKALDDSACPQPRPPVLEACHGPTC 944
W +G WS CS +C G+++R V C +S E L D C QP+P ++AC+ C
Sbjct: 669 RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNC 728
Query: 945 PPEWAALDWSECTPSCGPGLRHRVVLCKS--ADHR-ATLPPAHCSPAAKPPATMRCNLRR 1001
PP W W C+ +CG G++ R VLCK AD LP CS A+KP C
Sbjct: 729 PPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDD 787
Query: 1002 CPPARWVAGEWGECSAQCGVGQRQRSVRC 1030
C P+ W+ +W ECS CG G + RS C
Sbjct: 788 C-PSEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 150 bits (378), Expect = 8e-36
Identities = 96/283 (33%), Positives = 133/283 (46%), Gaps = 21/283 (7%)
Query: 827 YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886
Y W CSA C G VQ R L+S+ V P +C+ + + ACN CP
Sbjct: 1489 YWWSVDRLATCSASC-GNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
Query: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ--PRPPVLEACHGPTC 944
W+V +WS C+RSC GV++R V CQ+ ++ + + C Q RP +AC+ C
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
Query: 945 PPEWAALDWSECTPSC-GPGL--RHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRR 1001
EWA W +C C GP L +HR V C++ D TLP CS +P +T C
Sbjct: 1608 -VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD-GITLPSEQCSALPRPVSTQNCWSEA 1665
Query: 1002 CPPARWVAGEWGECSAQCG-VGQRQRSVRCT-SHTGQA--SHECTEALRPPTTQQCEAKC 1057
C W W C+A CG G + R V C + T +A H C+ RP Q+C
Sbjct: 1666 C-SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI-- 1722
Query: 1058 DSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
TP + EC+D + YC V + + C + F+ CC TC
Sbjct: 1723 ---TPCEN-MECRDTTR--YCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 111 bits (277), Expect = 4e-24
Identities = 59/185 (31%), Positives = 85/185 (45%), Gaps = 15/185 (8%)
Query: 826 PYSWHYAPWTKCSAQCAGGSQVQAVECRNQL-----DSSAVAPHYCSAHSKLPKRQRACN 880
P W W+ CS C G Q + V C + L ++ +A C P +ACN
Sbjct: 667 PARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELC--RQPKPSTVQACN 724
Query: 881 TEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACH 940
CPP W W CSR+C GV+ R V+C++R++ L ++ C +P +AC
Sbjct: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACK 784
Query: 941 GPTCPPEWAALDWSECTPSCGPGLRHRVVLCK-------SADHRATL-PPAHCSPAAKPP 992
CP EW DW+EC+ SCG G + R +C+ S +TL PP S + +P
Sbjct: 785 KDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPC 844
Query: 993 ATMRC 997
C
Sbjct: 845 MLATC 849
Score = 104 bits (259), Expect = 5e-22
Identities = 74/257 (28%), Positives = 101/257 (39%), Gaps = 37/257 (14%)
Query: 834 WTKCSAQCAGGSQVQAVECRNQLD-SSAVAP-HYCSAHSKLPKRQRACNTEPCPP----- 886
W+ C+ C G+QV+ V C+ L S +VA P QRAC PC
Sbjct: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEF 590
Query: 887 -------------------DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSA 927
DW ++ CS SC GV+ V C + + E A ++
Sbjct: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQT--REPAEENLC 648
Query: 928 CPQPRPP-VLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLC-----KSADHRATLP 981
RPP +L++C+ CP W WS C+ +CG GL+ R V C + + L
Sbjct: 649 VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILA 708
Query: 982 PAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASH-E 1040
C KP CN CPPA W +W CS CG G ++R V C S E
Sbjct: 709 DELCRQP-KPSTVQACNRFNCPPA-WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE 766
Query: 1041 CTEALRPPTTQQCEAKC 1057
E + C+ C
Sbjct: 767 LPETFCSASKPACQQAC 783
Score = 94.4 bits (233), Expect = 5e-19
Identities = 72/285 (25%), Positives = 109/285 (38%), Gaps = 61/285 (21%)
Query: 829 WHYAPWTKCSAQCAGGSQVQAVEC---------------RNQLDSSAVAPHYC------- 866
W W+ C+ C G + + V C + + + P C
Sbjct: 440 WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKL 499
Query: 867 SAHSKLPKRQRACNTEPCP-----PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEK 921
+KLP ++A E P ++ WS C+ +C G + R V CQ +S ++
Sbjct: 500 PVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSV 559
Query: 922 A-LDDSACPQPRPPVLEACHGPTCPPE------------------------WAALDWSEC 956
A L C P+P AC+ C E W +++C
Sbjct: 560 ADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKC 619
Query: 957 TPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMR-CNLRRCPPARWVAGEWGEC 1015
+ SCG G++ VV C + R C + +PP ++ CNL CP ARW G+W C
Sbjct: 620 SESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP-ARWEIGKWSPC 678
Query: 1016 SAQCGVGQRQRSVRCT-------SHTGQASHECTEALRPPTTQQC 1053
S CGVG + R V C+ + T + E +P T Q C
Sbjct: 679 SLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQAC 723
Score = 89.4 bits (220), Expect = 2e-17
Identities = 55/185 (29%), Positives = 75/185 (40%), Gaps = 13/185 (7%)
Query: 826 PYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAP---HYCSAHSKLPKRQRACNTE 882
P W W+ C+ C GG Q + V C+ S P C+ +K P +ACN +
Sbjct: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
Query: 883 PCPPDWVVGNWSLCSRSC---DAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEA 938
C +W +W C+ C V+ R V CQ R + L C PRP +
Sbjct: 1606 LC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR----DGITLPSEQCSALPRPVSTQN 1660
Query: 939 CHGPTCPPEWAALDWSECTPSCGP-GLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC 997
C C W W+ CT +CG G + R V C A +P CS +P RC
Sbjct: 1661 CWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRC 1720
Query: 998 NLRRC 1002
N+ C
Sbjct: 1721 NITPC 1725
Score = 38.1 bits (87), Expect = 0.046
Identities = 31/122 (25%), Positives = 45/122 (36%), Gaps = 17/122 (13%)
Query: 487 SRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGV 546
S C G +++C +R + ++ A+ Q C + C P
Sbjct: 679 SLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP-------- 730
Query: 547 DGAWGPWTPWGDCSRTCGGGVSS-----SSRHCDSPRPTIGGKYCLGERRR-HRSCNTDD 600
AW P W CSRTCGGGV R D + +C + ++C DD
Sbjct: 731 --AWYP-AQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
Query: 601 CP 602
CP
Sbjct: 788 CP 789
Score = 35.4 bits (80), Expect = 0.30
Identities = 48/188 (25%), Positives = 59/188 (31%), Gaps = 58/188 (30%)
Query: 559 CSRTCGGGVSSSSRHC--DSPRPTIGGKYCLGERRRH---RSCNTDDCPPGSQDFREVQC 613
CS +CGGGV + C R C+ RR +SCN D CP
Sbjct: 619 CSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA---------- 668
Query: 614 SEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTE------------RAAAVVDG 661
R + KW CSLTC G T ++
Sbjct: 669 --------RWEIGKW--------SPCSLTC---GVGLQTRDVFCSHLLSREMNETVILAD 709
Query: 662 TPCR---PDTVDICVSGEC-------KHVGCDRVLGSDL--REDKCRVCGGDGSACETIE 709
CR P TV C C + C R G + RE C+ DGS E E
Sbjct: 710 ELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPE 769
Query: 710 GVFSPASP 717
S + P
Sbjct: 770 TFCSASKP 777
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 285 bits (730), Expect = 1e-76
Identities = 183/583 (31%), Positives = 272/583 (46%), Gaps = 91/583 (15%)
Query: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPP 603
E DG W W W DCSRTCGGG S S R C + G+ C G+ R+++C+ DCPP
Sbjct: 72 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNHDCPP 125
Query: 604 GSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTP 663
++DFR QCS ++ + ++G +Y+W C+L C A+G N E A V+DGT
Sbjct: 126 DAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
Query: 664 CRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVF-SPASPGAGYE 722
C D++D+C+SG C+ VGCDR LGS+ +ED C VC GDGS C + G S SP E
Sbjct: 186 CNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREE 245
Query: 723 DVVWIPKG--SVHIFIQDLNLSLSHLALKGDQESLLLEGLPGT---PQPHRLPLAGTTFQ 777
+V+ +P G SV I ++ +HL + ES L+G G P + TT +
Sbjct: 246 NVIAVPLGSRSVRITVK----GPAHLFI----ESKTLQGSKGEHSFNSPGVFLVENTTVE 297
Query: 778 LRQGPDQVQSLEALGPINASLIVMV-LARTELPALRYRFNAPIARDSLPPYSWHYAPWTK 836
++G ++ Q+ + GP+ A I + +++ F PI+ + W +
Sbjct: 298 FQRGSER-QTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPIS------HQWRQTDFFP 350
Query: 837 CSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPK---RQRACNTEPCP-------- 885
C+ C GG Q+ + EC + V HYC + + K + + C+ +PCP
Sbjct: 351 CTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEI 410
Query: 886 ---------PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPV 935
P W W+ CS SC G++ RS VC E +++ C P+P V
Sbjct: 411 MPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKV 470
Query: 936 LEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHR------------------ 977
++ C+ C P+W A++WS+CT +CG GLR+RVVLC +HR
Sbjct: 471 MQTCNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLC--INHRGEHVGGCNPQLKLHIKEE 527
Query: 978 ATLPPAHCSPAAKPPATMRCNLRR-----------CPPARWVAGEWGECSAQCGVGQRQR 1026
+P P K P + + ++ W CS CG G + R
Sbjct: 528 CVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVR 587
Query: 1027 SVRC-------TSHTGQASHECTEALRPPTTQQC--EAKCDSP 1060
V+C + T EC E + PT + C EA +SP
Sbjct: 588 EVKCRVLLTFTQTETELPEEEC-EGPKLPTERPCLLEACDESP 629
Score = 145 bits (367), Expect = 2e-34
Identities = 76/226 (33%), Positives = 103/226 (45%), Gaps = 8/226 (3%)
Query: 807 ELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYC 866
E PA R + P+ DS Y W YA +T C+A C GG Q C + V C
Sbjct: 627 ESPASR-ELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC 685
Query: 867 SAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDS 926
+ P +ACNTEPCPP W VG+W CS +C G+++R V C E
Sbjct: 686 DMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLH----PGETPAPPE 741
Query: 927 ACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKS--ADHRATLPPAH 984
C +P L+AC+ CPP W +W +C+ +CG G ++R V C+ D
Sbjct: 742 ECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE 801
Query: 985 CSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRC 1030
K + C CPP G+W +CS CGVG ++R C
Sbjct: 802 LCQGPKASSHKSCARTDCPP-HLAVGDWSKCSVSCGVGIQRRKQVC 846
Score = 112 bits (279), Expect = 3e-24
Identities = 57/180 (31%), Positives = 82/180 (45%), Gaps = 6/180 (3%)
Query: 826 PYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCP 885
P WH W CSA C G Q + V C + ++ A P C + P +ACN CP
Sbjct: 704 PPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPA-PPEEC--RDEKPHALQACNQFDCP 760
Query: 886 PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCP 945
P W + W CSR+C G ++R V C++ ++ L D C P+ ++C CP
Sbjct: 761 PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCP 820
Query: 946 PEWAALDWSECTPSCGPGLRHRVVLCK---SADHRATLPPAHCSPAAKPPATMRCNLRRC 1002
P A DWS+C+ SCG G++ R +C+ + R L C P C + C
Sbjct: 821 PHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPEC 880
Score = 108 bits (271), Expect = 2e-23
Identities = 84/306 (27%), Positives = 119/306 (38%), Gaps = 33/306 (10%)
Query: 808 LPALRYRFNAPIARDSLPPYS--WHYAPWTKCSAQCAG-GSQVQAVECRNQLDSSAVAPH 864
L A R N+ PP W W+ CSA C G+++Q +C + V+
Sbjct: 1405 LQATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEA 1463
Query: 865 YCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALD 924
C K CN CP W WS CS SC G SR V C+R + + +
Sbjct: 1464 LCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVS 1523
Query: 925 DSAC-PQPRPPVLEACHGPTCPPEWAALDWSECTPSC---GPGLRHRVVLCKSADHRATL 980
AC P+ RP + C G C +W + C C ++ R C+ H ++
Sbjct: 1524 PRACAPKDRPLGRKPCFGHPC-VQWE--PGNRCPGRCMGRAVRMQQRHTACQ---HNSS- 1576
Query: 981 PPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQ---- 1036
++C +P C C W G W C+A CG G + R V C HT
Sbjct: 1577 -DSNCDDRKRPTLRRNCTSGACDVC-WHTGPWKPCTAACGRGFQSRKVDCI-HTRSCKPV 1633
Query: 1037 ASHECTEALRPPTTQQC-EAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQM 1095
A C + +P + + C CD +C D YC V CS ++Q
Sbjct: 1634 AKRHCVQKKKPISWRHCLGPSCD--------RDCTDTTH--YCMFVKHLNLCSLDRYKQR 1683
Query: 1096 CCKTCQ 1101
CC++CQ
Sbjct: 1684 CCQSCQ 1689
Score = 82.8 bits (203), Expect = 2e-15
Identities = 92/365 (25%), Positives = 129/365 (35%), Gaps = 100/365 (27%)
Query: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAV--APHYCSAHSKLPKRQRACNTEPCPP 886
W + PWT CS C GG Q ++ C + + + ++ PK + CN CP
Sbjct: 422 WEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPK 481
Query: 887 DWVVGNWSLCSRSCDAGVRSRSVVC-------------QRRVSAAEEKALDDSAC-PQPR 932
W+ WS C+ +C G+R R V+C Q ++ EE + P+ +
Sbjct: 482 -WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
Query: 933 PPV------------LEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCK----SADH 976
PV LE T P + WS C+ +CGPG++ R V C+
Sbjct: 541 SPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQT 600
Query: 977 RATLPPAHCSPAAKPPATMRCNLRRC---PPAR---------------WVAGEWGECSAQ 1018
LP C K P C L C P +R W + C+A
Sbjct: 601 ETELPEEECE-GPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTAT 659
Query: 1019 CGVGQRQRSVRCTSH--TGQASHE--CTEALRPPTTQQ------------------CEAK 1056
C VG Q ++ H T Q ++ C RPP Q C A
Sbjct: 660 C-VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSAT 718
Query: 1057 C---------------DSPTPGDGPEECKDVNKVAYCPLVLKFQF-CSRAYF---RQMCC 1097
C ++P P PEEC+D A L QF C + Q C
Sbjct: 719 CGVGIQTRDVYCLHPGETPAP---PEECRDEKPHA---LQACNQFDCPPGWHIEEWQQCS 772
Query: 1098 KTCQG 1102
+TC G
Sbjct: 773 RTCGG 777
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/61 (36%), Positives = 29/61 (47%), Gaps = 2/61 (3%)
Query: 556 WGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRH--RSCNTDDCPPGSQDFREVQC 613
WG CS TCG G+ + +C P T + + H ++CN DCPPG QC
Sbjct: 712 WGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQC 771
Query: 614 S 614
S
Sbjct: 772 S 772
Score = 40.8 bits (94), Expect = 0.007
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 6/54 (11%)
Query: 556 WGDCSRTCGGGVSSSSRHC-----DSPRPTIGGKYCLGER-RRHRSCNTDDCPP 603
W CSRTCGGG + C D + + C G + H+SC DCPP
Sbjct: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
Score = 32.0 bits (71), Expect = 3.3
Identities = 30/112 (26%), Positives = 43/112 (38%), Gaps = 28/112 (25%)
Query: 507 RCITNSIPAAEG-TLCQTHTIDKGWC--YKRVCVPFGSRPEGVDGAW--GPWTPWGDCSR 561
RC+ ++ + T CQ ++ D C KR + D W GPW P C+
Sbjct: 1556 RCMGRAVRMQQRHTACQHNSSDSN-CDDRKRPTLRRNCTSGACDVCWHTGPWKP---CTA 1611
Query: 562 TCGGGVSS--------------SSRHCDSPRPTIGGKYCLGERRRHRSCNTD 599
CG G S + RHC + I ++CLG SC+ D
Sbjct: 1612 ACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP-----SCDRD 1658
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 284 bits (726), Expect = 4e-76
Identities = 173/485 (35%), Positives = 236/485 (48%), Gaps = 59/485 (12%)
Query: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPP 603
E DG W W PW +CSRTCGGG S S R C + K C G R+R+C+ DCPP
Sbjct: 30 EDRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPP 83
Query: 604 GSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTP 663
+ DFR QCS + + G+FY+W CSL C A+G E A V+DGT
Sbjct: 84 EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 143
Query: 664 CRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVF-SPASPGAGYE 722
C +++D+C+SG C+ VGCD LGS ++ED C VC GDGS C + G + S S +
Sbjct: 144 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDD 203
Query: 723 DVVWIPKGSVHIFIQDLNLSLSHLALKG-DQESLLLEGLPGTPQPHRLPLAGT------T 775
VV IP GS HI L LKG D L + L GT + L GT +
Sbjct: 204 TVVAIPYGSRHI----------RLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSS 253
Query: 776 FQLRQGPDQVQSLEALGPINASLIVMVL-ARTELPALRYRFNAPIARDSLPPYSWHYAPW 834
++ PD+ + L GP+ A IV + + + +++ F PI + W +
Sbjct: 254 VDFQKFPDK-EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII------HRWRETDF 306
Query: 835 TKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSK----LPKRQRACNTEPCP----- 885
CSA C GG Q+ + EC + + VA YC + + PK Q CN +PCP
Sbjct: 307 FPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNLDPCPASDGY 365
Query: 886 ------------PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPR 932
P W W+ CS SC G++SR+V C ++++ C P+
Sbjct: 366 KQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPK 425
Query: 933 PPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP 992
P+ + C+ C P+W A +WS CT +CG GLR+RVVLC DHR + CSP KP
Sbjct: 426 MPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLC--IDHRG-MHTGGCSPKTKPH 481
Query: 993 ATMRC 997
C
Sbjct: 482 IKEEC 486
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 266 bits (680), Expect = 8e-71
Identities = 170/505 (33%), Positives = 245/505 (48%), Gaps = 42/505 (8%)
Query: 586 CLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRG-GGVKACSLTCL 644
C+G R+++ CNT+ CP S+ REVQC+ +++ PF G+FY+W+ + G + C L C
Sbjct: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQ 350
Query: 645 AEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSA 704
A G+ FY +A V+DGTPC + ICVSG+CK +GCD LGSD DKC VCGGD +
Sbjct: 351 AMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTG 410
Query: 705 CETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTP 764
C+ + GVF A GY VV IP+G+ I I ++ S ++LAL+ ++ G
Sbjct: 411 CQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID 470
Query: 765 QPHRLPLAGTTFQLRQGPDQV-----QSLEALGPINASLIVMVLARTELPALRYRFNAPI 819
+P + GT F ++ P+++ +S A GP N L V ++ + P + Y +
Sbjct: 471 RPGKYEGGGTMFTYKR-PNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMG 529
Query: 820 ARDSLPPYSWHYAPWTKCSAQCA--GGSQVQAVE-CRNQ--LDSSAVAPHYCSAHS---- 870
P H P + Q G SQ + + RN+ D AP ++ S
Sbjct: 530 TNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTF 589
Query: 871 --KLPKR---QRACNTEPCPP---------DWVVGNWSLCSRSCDAGVRSRSVVCQRRVS 916
+ P R R N P P +W + CS +C G + C R +
Sbjct: 590 PVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRST 649
Query: 917 --AAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKS- 973
A E D S P P E C+ CP W +WSEC+ +CG G++HR VLC+
Sbjct: 650 HEEAPESYCDSSMKPTPEE---EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQV 706
Query: 974 -ADHRATLPPAHCSPAAKPPATMRCNLRRCPPARW-VAGEWGECSAQCGVGQRQRSVRCT 1031
A+ T+ P C KP T C L+ C + W + +W CS CGVGQR R V+C
Sbjct: 707 YANRSLTVQPYRCQHLEKPETTSTCQLKIC--SEWQIRTDWTSCSVPCGVGQRTRDVKCV 764
Query: 1032 SHTGQA--SHECTEALRPPTTQQCE 1054
S+ G EC LRP + C+
Sbjct: 765 SNIGDVVDDEECNMKLRPNDIENCD 789
Score = 154 bits (390), Expect = 3e-37
Identities = 92/272 (33%), Positives = 126/272 (46%), Gaps = 17/272 (6%)
Query: 834 WTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNW 893
WT CS C G + + V+C + + V C+ + P C+ PC W + W
Sbjct: 745 WTSCSVPCGVGQRTRDVKCVSNI-GDVVDDEECNMKLR-PNDIENCDMGPCAKSWFLTEW 802
Query: 894 S-LCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPP--EWAA 950
S CS C AGVR+RSVVC +L C RP C C EW A
Sbjct: 803 SERCSAECGAGVRTRSVVCMTN----HVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFA 858
Query: 951 LDWSECTPSCGPGLRHRVVLC--KSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWV 1008
WS+C+ CG G + R V+C K+AD L P+ CS KPP+ C+L+ C A+W
Sbjct: 859 GSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCG-AKWF 917
Query: 1009 AGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEE 1068
+ EW CS C G R R VRC S S+ C L+P + C + P + E
Sbjct: 918 STEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVP---EVDEN 974
Query: 1069 CKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
CKD K C +V++ + C Y++ CC +C
Sbjct: 975 CKD--KYYNCNVVVQARLCVYNYYKTACCASC 1004
Score = 102 bits (254), Expect = 2e-21
Identities = 61/181 (33%), Positives = 85/181 (46%), Gaps = 11/181 (6%)
Query: 828 SWHYAPWT-KCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886
SW W+ +CSA+C G + ++V C SS + P C+ PC
Sbjct: 796 SWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLE---GCGNNRPAEATPCDNGPCTG 852
Query: 887 --DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPVLEACHGPT 943
+W G+WS CS C +G + R V+C R+ +A + LD S C +PP ++CH
Sbjct: 853 KVEWFAGSWSQCSIECGSGTQQREVICVRK-NADTFEVLDPSECSFLEKPPSQQSCHLKP 911
Query: 944 CPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP 1003
C +W + +WS C+ SC G R R V C S D TL C P KP CN + C
Sbjct: 912 CGAKWFSTEWSMCSKSCQGGFRVREVRCLSDD--MTLSNL-CDPQLKPEERESCNPQDCV 968
Query: 1004 P 1004
P
Sbjct: 969 P 969
Score = 79.3 bits (194), Expect = 2e-14
Identities = 42/121 (34%), Positives = 61/121 (50%), Gaps = 8/121 (6%)
Query: 829 WHYAPWTKCSAQCAGGSQVQAVEC-RNQLDSSAVA-PHYCSAHSKLPKRQRACNTEPCPP 886
W W++CS +C G+Q + V C R D+ V P CS K P Q++C+ +PC
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEK-PPSQQSCHLKPCGA 914
Query: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPP 946
W WS+CS+SC G R R V C +++ L + PQ +P E+C+ C P
Sbjct: 915 KWFSTEWSMCSKSCQGGFRVREVRC-----LSDDMTLSNLCDPQLKPEERESCNPQDCVP 969
Query: 947 E 947
E
Sbjct: 970 E 970
Score = 46.2 bits (108), Expect = 2e-04
Identities = 16/30 (53%), Positives = 18/30 (60%)
Query: 545 GVDGAWGPWTPWGDCSRTCGGGVSSSSRHC 574
G G WG W PW CSR+C GGV +R C
Sbjct: 51 GAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 34.7 bits (78), Expect = 0.51
Identities = 23/64 (35%), Positives = 28/64 (43%), Gaps = 13/64 (20%)
Query: 861 VAPHYCSAHSKLPKRQRACNTEPCPPD---------WVV-GNWSLCSRSCDAGVRSRSVV 910
V P + H K+P+R A E P D W G WS CSRSC GV ++
Sbjct: 23 VCPQPSTQHRKVPQRMAA---EGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRP 79
Query: 911 CQRR 914
C R
Sbjct: 80 CLPR 83
Score = 30.4 bits (67), Expect = 9.6
Identities = 17/52 (32%), Positives = 22/52 (42%), Gaps = 3/52 (5%)
Query: 554 TPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERR--RHRSCNTDDCPP 603
T W CS++C GG C S T+ C + + SCN DC P
Sbjct: 919 TEWSMCSKSCQGGFRVREVRCLSDDMTL-SNLCDPQLKPEERESCNPQDCVP 969
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 261 bits (668), Expect = 2e-69
Identities = 165/492 (33%), Positives = 228/492 (46%), Gaps = 41/492 (8%)
Query: 586 CLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRG-GGVKACSLTCL 644
C GE + R+C+ CPP D R +QC+ F+S F G+ Y+W+ + G + C L C
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 645 AEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSA 704
GF FY V DGT C+P DICV+G C GCD +LGS R D C VCGGD S
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 705 CETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTP 764
C + G + GY+ ++WIP G++ + I L S ++LAL+G ++ G
Sbjct: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
Query: 765 QPHRLPLAGTTFQLRQGPDQV---QSLEALGPINASLIVMVLARTELPALRYRFNAPIAR 821
P GT F+ + P + +SL A GP + V ++ + E P + Y++
Sbjct: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQY----VI 599
Query: 822 DSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNT 881
S PP + P Q+Q R + A AP L +RQ
Sbjct: 600 SSPPPILENPTPEPPV-------PQLQPEILRVE-PPLAPAPRPARTPGTL-QRQVRIPQ 650
Query: 882 EPCPPD-----------WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ 930
P PP W S CS SC GV +C R S E LD+ +C
Sbjct: 651 MPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEE---LDERSCAA 707
Query: 931 -PRPPVL-EACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKS--ADHRATLPPAHCS 986
RPP E CHG CPP W A +W+ C+ SCGPG +HR + C+ +++PP C
Sbjct: 708 GARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
Query: 987 PAAKPPATMRCNLRRCPPARWVAGE-WGECSAQCGVGQRQRSVRCTSHTGQ--ASHECTE 1043
+P T C LR C W G W +CS +CG GQR R VRC + G + EC
Sbjct: 768 HLPRPNITQSCQLRLC--GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECAS 825
Query: 1044 A-LRPPTTQQCE 1054
+PP+ + C+
Sbjct: 826 GPPQPPSREACD 837
Score = 154 bits (388), Expect = 6e-37
Identities = 88/280 (31%), Positives = 129/280 (46%), Gaps = 18/280 (6%)
Query: 832 APWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVG 891
+PW++CS +C G + + V C + V+ C++ P + AC+ PC W
Sbjct: 790 SPWSQCSVRCGRGQRSRQVRCVGN-NGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
Query: 892 NWSL-CSRSCDAGVRSRSVVCQRRVSA-----AEEKALDDSACPQ-PRPPVLEACHGPTC 944
+WS CS C G++ RSVVC +A E A +CP RPP + AC C
Sbjct: 849 DWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC 908
Query: 945 PPEWAALD--WSECTPSCGPGLRHRVVLC--KSADHRATLPPAHCSPAAKPPATMRCNLR 1000
W W EC+ CG G + R ++C K P++CS +PPA C +
Sbjct: 909 ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQ 968
Query: 1001 RCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSP 1060
C RW + W CS C G + R V+C S S C LRP + C ++ S
Sbjct: 969 ACQD-RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
Query: 1061 TPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
P D +CKD + +CPLV++ + C Y+ CC++C
Sbjct: 1028 RPDD---QCKDSS--PHCPLVVQARLCVYPYYTATCCRSC 1062
Score = 48.1 bits (113), Expect = 4e-05
Identities = 17/34 (50%), Positives = 20/34 (58%)
Query: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSP 577
+G +G WGPW W CS+ CG GV SR C P
Sbjct: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 38.9 bits (89), Expect = 0.027
Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 7/64 (10%)
Query: 554 TPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERR--RHRSCNTDDCPPGSQDFREV 611
TPW CSR+C GG + C S T+ + C + R R R CN+ C D
Sbjct: 977 TPWSPCSRSCQGGTQTREVQCLSTNQTLSTR-CPPQLRPSRKRPCNSQPCSQRPDD---- 1031
Query: 612 QCSE 615
QC +
Sbjct: 1032 QCKD 1035
Score = 33.9 bits (76), Expect = 0.87
Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 3/62 (4%)
Query: 1007 WVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPT-TQQCEAKCDSPTPGDG 1065
WV +W CS CGVG ++RS C T Q RPP + + P P
Sbjct: 50 WV--QWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTS 107
Query: 1066 PE 1067
PE
Sbjct: 108 PE 109
Score = 33.1 bits (74), Expect = 1.5
Identities = 32/107 (29%), Positives = 41/107 (38%), Gaps = 32/107 (29%)
Query: 538 PFGSRPEGV--------DGAWGPWT-PWGDCSRTCGGG-----------------VSSSS 571
P GSRP + + W +T PWG+CS CG G V+S S
Sbjct: 892 PTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPS 951
Query: 572 RHCDSPRPTIGGKYCLGERRRHRSCNTDDCP-----PGSQDFREVQC 613
PRP + C G+ + R +T P G REVQC
Sbjct: 952 NCSHLPRPP-ALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQC 997
Score = 30.4 bits (67), Expect = 9.6
Identities = 22/68 (32%), Positives = 26/68 (38%), Gaps = 7/68 (10%)
Query: 867 SAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDS 926
S HS + E WV W+ CS+ C GV+ RS CQ L S
Sbjct: 29 SGHSLQTPTEEGQGPEGVWGPWV--QWASCSQPCGVGVQRRSRTCQ-----LPTVQLHPS 81
Query: 927 ACPQPRPP 934
PRPP
Sbjct: 82 LPLPPRPP 89
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 261 bits (668), Expect = 2e-69
Identities = 165/492 (33%), Positives = 228/492 (46%), Gaps = 41/492 (8%)
Query: 586 CLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRG-GGVKACSLTCL 644
C GE + R+C+ CPP D R +QC+ F+S F G+ Y+W+ + G + C L C
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 645 AEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSA 704
GF FY V DGT C+P DICV+G C GCD +LGS R D C VCGGD S
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 705 CETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTP 764
C + G + GY+ ++WIP G++ + I L S ++LAL+G ++ G
Sbjct: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
Query: 765 QPHRLPLAGTTFQLRQGPDQV---QSLEALGPINASLIVMVLARTELPALRYRFNAPIAR 821
P GT F+ + P + +SL A GP + V ++ + E P + Y++
Sbjct: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQY----VI 599
Query: 822 DSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNT 881
S PP + P Q+Q R + A AP L +RQ
Sbjct: 600 SSPPPILENPTPEPPV-------PQLQPEILRVE-PPLAPAPRPARTPGTL-QRQVRIPQ 650
Query: 882 EPCPPD-----------WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ 930
P PP W S CS SC GV +C R S E LD+ +C
Sbjct: 651 MPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEE---LDERSCAA 707
Query: 931 -PRPPVL-EACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKS--ADHRATLPPAHCS 986
RPP E CHG CPP W A +W+ C+ SCGPG +HR + C+ +++PP C
Sbjct: 708 GARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
Query: 987 PAAKPPATMRCNLRRCPPARWVAGE-WGECSAQCGVGQRQRSVRCTSHTGQ--ASHECTE 1043
+P T C LR C W G W +CS +CG GQR R VRC + G + EC
Sbjct: 768 HLPRPNITQSCQLRLC--GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECAS 825
Query: 1044 A-LRPPTTQQCE 1054
+PP+ + C+
Sbjct: 826 GPPQPPSREACD 837
Score = 95.9 bits (237), Expect = 2e-19
Identities = 50/188 (26%), Positives = 75/188 (39%), Gaps = 1/188 (0%)
Query: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
P W + CSA C G C ++ + C+A ++ P C+ PC
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
Query: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTC 944
PP W G W+ CSRSC G + R + C++ + PRP + ++C C
Sbjct: 724 PPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
Query: 945 PPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004
WS+C+ CG G R R V C + S +PP+ C++ C
Sbjct: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTT 843
Query: 1005 ARWVAGEW 1012
A W +W
Sbjct: 844 A-WFHSDW 850
Score = 79.7 bits (195), Expect = 1e-14
Identities = 48/133 (36%), Positives = 62/133 (46%), Gaps = 8/133 (6%)
Query: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDS--SAVAPHYCSAHSKLPKRQRACNTE 882
PPY W WT CS C G+Q + ++CR + S+V P C H P ++C
Sbjct: 724 PPY-WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG-HLPRPNITQSCQLR 781
Query: 883 PCPPDWVVGN-WSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHG 941
C W VG+ WS CS C G RSR V C + +E + + A P+PP EAC
Sbjct: 782 LCG-HWEVGSPWSQCSVRCGRGQRSRQVRCVG--NNGDEVSEQECASGPPQPPSREACDM 838
Query: 942 PTCPPEWAALDWS 954
C W DWS
Sbjct: 839 GPCTTAWFHSDWS 851
Score = 48.1 bits (113), Expect = 4e-05
Identities = 17/34 (50%), Positives = 20/34 (58%)
Query: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSP 577
+G +G WGPW W CS+ CG GV SR C P
Sbjct: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 33.9 bits (76), Expect = 0.87
Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 3/62 (4%)
Query: 1007 WVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPT-TQQCEAKCDSPTPGDG 1065
WV +W CS CGVG ++RS C T Q RPP + + P P
Sbjct: 50 WV--QWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTS 107
Query: 1066 PE 1067
PE
Sbjct: 108 PE 109
Score = 30.4 bits (67), Expect = 9.6
Identities = 22/68 (32%), Positives = 26/68 (38%), Gaps = 7/68 (10%)
Query: 867 SAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDS 926
S HS + E WV W+ CS+ C GV+ RS CQ L S
Sbjct: 29 SGHSLQTPTEEGQGPEGVWGPWV--QWASCSQPCGVGVQRRSRTCQ-----LPTVQLHPS 81
Query: 927 ACPQPRPP 934
PRPP
Sbjct: 82 LPLPPRPP 89
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 222 bits (565), Expect = 2e-57
Identities = 154/468 (32%), Positives = 228/468 (48%), Gaps = 55/468 (11%)
Query: 74 SRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQAS 133
S LFY V L L ++RL+A ++E+ +G CLY G + G A
Sbjct: 107 SHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAE 166
Query: 134 TSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSLRHP----- 188
S VA+S C GL GLI +EEE+ IEPL G ++ E+ HVVY+R P
Sbjct: 167 ASSVALSNCDGLAGLIRMEEEEFFIEPLEKG-LAAQEAEQGRVHVVYRRPPTSPPLGGPQ 225
Query: 189 HLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRS----VSRERYVETL 244
LDT + L +L +R LG E +R+ + +E L
Sbjct: 226 ALDTGASLDS----------LDSL----SRALGVLEEHANSSRRRARRHAADDDYNIEVL 271
Query: 245 VVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLT--EDQPTLE 302
+ D +V +HG+ V++Y+L +MNIV +++ D SLG+ +N+++ R+ILL+ + +E
Sbjct: 272 LGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIE 331
Query: 303 ITHHAGKSLDSFCKW----QKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPC 358
I + + +SL++ C+W QK H + HD A+ +TR D P
Sbjct: 332 IGNPS-QSLENVCRWAYLQQKPDTGHDEY-----------HDHAIFLTRQDF-----GPS 374
Query: 359 GTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAK 418
G G APV GMC RSC++N + G ++AF +AHE GH GM HDG GN CG +
Sbjct: 375 GMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVR-LGS 433
Query: 419 LMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQ 478
+MA + + F WS CS+ ++ +L S CL + P D+ PG Y +EQ
Sbjct: 434 IMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQLPGLHYSMNEQ 491
Query: 479 CRFQHGVKSRQC---KYGEVCSELWCLSKSNR--CITNSIPAAEGTLC 521
CRF G+ C + + C +LWC N C T P +GT+C
Sbjct: 492 CRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMC 539
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.449
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,170,216
Number of Sequences: 37866
Number of extensions: 2849720
Number of successful extensions: 10377
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 8193
Number of HSP's gapped (non-prelim): 1039
length of query: 1103
length of database: 18,247,518
effective HSP length: 113
effective length of query: 990
effective length of database: 13,968,660
effective search space: 13828973400
effective search space used: 13828973400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.