Search of human proteins with 134304853

Search of human proteins with 134304853

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134304853 PTPL1-associated RhoGAP 1 [Homo sapiens]
         (1261 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134304853 PTPL1-associated RhoGAP 1 [Homo sapiens]                2501   0.0  
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]      590   e-168
gi|91208437 GEM interacting protein [Homo sapiens]                    477   e-134
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     120   8e-27
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    120   8e-27
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            115   2e-25
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          114   4e-25
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]           108   3e-23
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...   103   8e-22
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...   103   8e-22
gi|156119615 myosin IXA [Homo sapiens]                                103   1e-21
gi|33356170 myosin IXB isoform 1 [Homo sapiens]                       100   9e-21
gi|188497642 ARHGAP15 [Homo sapiens]                                  100   1e-20
gi|194272142 myosin IXB isoform 2 [Homo sapiens]                       98   6e-20
gi|229094128 active breakpoint cluster region-related  protein i...    97   7e-20
gi|38679957 active breakpoint cluster region-related  protein is...    97   7e-20
gi|38679954 active breakpoint cluster region-related  protein is...    97   7e-20
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           97   1e-19
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]           95   5e-19
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]            95   5e-19
gi|186910302 Rac GTPase activating protein 1 [Homo sapiens]            94   1e-18
gi|186910300 Rac GTPase activating protein 1 [Homo sapiens]            94   1e-18
gi|21361397 Rac GTPase activating protein 1 [Homo sapiens]             94   1e-18
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap...    94   1e-18
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap...    94   1e-18
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap...    92   3e-18
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap...    92   3e-18
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]            92   4e-18
gi|4505507 oligophrenin 1 [Homo sapiens]                               91   5e-18
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]         91   9e-18

>gi|134304853 PTPL1-associated RhoGAP 1 [Homo sapiens]
          Length = 1261

 Score = 2501 bits (6481), Expect = 0.0
 Identities = 1261/1261 (100%), Positives = 1261/1261 (100%)

Query: 1    MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL 60
            MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
Sbjct: 1    MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL 60

Query: 61   YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV 120
            YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
Sbjct: 61   YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV 120

Query: 121  NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV 180
            NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
Sbjct: 121  NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV 180

Query: 181  DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM 240
            DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
Sbjct: 181  DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM 240

Query: 241  VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM 300
            VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
Sbjct: 241  VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM 300

Query: 301  EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL 360
            EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
Sbjct: 301  EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL 360

Query: 361  AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ 420
            AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
Sbjct: 361  AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ 420

Query: 421  CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG 480
            CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
Sbjct: 421  CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG 480

Query: 481  NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD 540
            NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
Sbjct: 481  NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD 540

Query: 541  SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT 600
            SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
Sbjct: 541  SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT 600

Query: 601  FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ 660
            FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
Sbjct: 601  FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ 660

Query: 661  KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ 720
            KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
Sbjct: 661  KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ 720

Query: 721  ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK 780
            ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
Sbjct: 721  ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK 780

Query: 781  KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK 840
            KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
Sbjct: 781  KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK 840

Query: 841  NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG 900
            NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
Sbjct: 841  NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG 900

Query: 901  VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL 960
            VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
Sbjct: 901  VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL 960

Query: 961  GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL 1020
            GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
Sbjct: 961  GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL 1020

Query: 1021 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI 1080
            PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
Sbjct: 1021 PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI 1080

Query: 1081 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE 1140
            QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
Sbjct: 1081 QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE 1140

Query: 1141 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG 1200
            RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
Sbjct: 1141 RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG 1200

Query: 1201 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF 1260
            LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF
Sbjct: 1201 LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQF 1260

Query: 1261 V 1261
            V
Sbjct: 1261 V 1261


>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
          Length = 1136

 Score =  590 bits (1521), Expect = e-168
 Identities = 370/1028 (35%), Positives = 564/1028 (54%), Gaps = 80/1028 (7%)

Query: 45   IKELVNDIRKFSHMLLYLKEAIFSDCFKEV----IHIRLEELLRVLKSIMNKHQNLNSVD 100
            I  L+ D+ +F+  L  LKE +  D   E      H  L E LRV+  I++K+  LN+V+
Sbjct: 116  ISHLLADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVE 175

Query: 101  LQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFS-SIETLAFTFGNILTNFLMGDVGNDS 159
               AA  L AKVKA ++     E+ NDL ++ F  ++ET+A  F + ++ FLMG+V + +
Sbjct: 176  TLTAAGTLIAKVKAFHY-----ESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSST 230

Query: 160  LLRLPVSRETKSFENV----------SVESVDSSSEKGNFSPLELDNVLLKNTDSIELAL 209
            LL +P    ++S E++          S+E  D+    G     E+D +L +    ++ AL
Sbjct: 231  LLAVPPGDSSQSMESLYGPGSEGTPPSLEDCDA----GCLPAEEVDVLLQRCEGGVDAAL 286

Query: 210  SYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLN 269
             YAK  +KY K+++S++EK+  LE+E  + + K+A   R ++  +  MPL S+++ AL  
Sbjct: 287  LYAKNMAKYMKDLISYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQ 346

Query: 270  DIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAK 329
            D+E  H + Q +  LQ   F+QPL  R+ E EK+RKEIKE W + Q K+ EAE+ L+KAK
Sbjct: 347  DLEFGHSMVQAVGTLQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAK 406

Query: 330  LLCMQRQDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELY 389
               +QR ++++KA+  + +AEEE   S+ G      K L+K+RRLEEEA  K EEA   Y
Sbjct: 407  QGYVQRCEDHDKARFLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATY 466

Query: 390  KVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQS 449
            + CV + + ++ +LE+TK   L Q++ ++ Q D T+K+ T++ + M H+Q A L    Q 
Sbjct: 467  RTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQM 526

Query: 450  LCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPAN----SLEDVVR 505
            LC+S+KLYDPGQ+Y+  V+     +E  V  +   H++++  S    A     ++ DV R
Sbjct: 527  LCESSKLYDPGQQYASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVAR 586

Query: 506  LPDSSNKIEEDRCSNSADI------TGPSFIRSWTFGMFSDSESTGGSSESRSLDSESIS 559
               + +  EE  C+            G    +SW   + SDS+S         LD     
Sbjct: 587  PEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSI-SDSDS--------GLD-PGPG 636

Query: 560  PGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNS--------------LGTFKKTL 605
             GDF +K  RT SSGTMSS ++L + +  + +     +               G F+   
Sbjct: 637  AGDF-KKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEG 695

Query: 606  MSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGK 665
            +SKAA TH+ RKLR+P KCR+C   V FQG ECEEC L CH+KCLE L I CGH+KL G+
Sbjct: 696  LSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGR 755

Query: 666  IHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENG 725
            + LFG +F+  A+  PDG+PFI+K C  EIE RAL  +GIYRV G K + EKLCQA ENG
Sbjct: 756  LQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENG 815

Query: 726  MHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLE 785
              LV++S+ S HDI +VLKLYLRQLPEP I FRLY E + LAK+      E +      +
Sbjct: 816  KELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQ 875

Query: 786  DKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVI 845
            D    +  + +  +  + ++LLR LP  N  SL +L+ HL+R+V+  ++NKM   NLG++
Sbjct: 876  DGS-ESEAVAV-ALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIV 933

Query: 846  FGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIF------------DGSLQPQ 893
            FGP+L+RPRPT A +++SSL +Y +QAR++E LI +   +F            + S Q  
Sbjct: 934  FGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRA 993

Query: 894  DVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIH-----TSESESKIFERAT 948
            +V+  +  ++ G      L     D  R  + +   S  D+       S SE+       
Sbjct: 994  EVVVQVPYLEAGEAVVYPLQEAAADGCRESRVVSNDSDSDLEEASELLSSSEASALGH-L 1052

Query: 949  SFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVER 1008
            SF E ++ + +L       S   +  L+  A       EDG   +     +++S N ++ 
Sbjct: 1053 SFLEQQQSEASLEVASGSHSGSEE-QLEATAREDGDGDEDGPAQQLSGFNTNQSNNVLQA 1111

Query: 1009 HTPRTKIR 1016
              P  ++R
Sbjct: 1112 PLPPMRLR 1119


>gi|91208437 GEM interacting protein [Homo sapiens]
          Length = 970

 Score =  477 bits (1228), Expect = e-134
 Identities = 302/788 (38%), Positives = 443/788 (56%), Gaps = 64/788 (8%)

Query: 129 FQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESVDSSSEKGN 188
           + ++F S++ L  + GN+    L GD     L   P   +T +    +  S  S      
Sbjct: 18  YSDIFRSLDNLEISLGNVTLEMLAGD---PLLSEDPEPDKTPTATVTNEASCWSGPSPEG 74

Query: 189 FSPL---ELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAE 245
             PL   ELD  L++    ++ AL YAKTWS+Y K +++W EK+ + ELE  ++ +K+AE
Sbjct: 75  PVPLTGEELDLRLIRTKGGVDAALEYAKTWSRYAKELLAWTEKRASYELEFAKSTMKIAE 134

Query: 246 ATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRK 305
           A + +I  Q  MPLQ ++T  L +D+    L  +T+A  Q   + QPL  ++ E+EK RK
Sbjct: 135 AGKVSIQQQSHMPLQYIYTLFLEHDLSLGTLAMETVAQ-QKRDYYQPLAAKRTEIEKWRK 193

Query: 306 EIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGLAKNLN 365
           E KE W +EQ +M EA  AL++A+L  +QR ++  +A+S     +    +S G      +
Sbjct: 194 EFKEQWMKEQKRMNEAVQALRRAQLQYVQRSEDL-RARSQGSPEDSAPQASPGP-----S 247

Query: 366 KQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTL 425
           KQ E++RR  EEA  K +EA  LY+ CV     R+ DLE  K+ I++ +R LVFQ D  L
Sbjct: 248 KQQERRRRSREEAQAKAQEAEALYQACVREANARQQDLEIAKQRIVSHVRKLVFQGDEVL 307

Query: 426 KAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKH 485
           + VT++LF ++  QA     +  +L +    ++PGQ Y EFV+A                
Sbjct: 308 RRVTLSLFGLRGAQAERGPRAFAALAECCAPFEPGQRYQEFVRA---------------- 351

Query: 486 LNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCS---------NSADI-----TGPSFIR 531
           L    P    PA S ++ +   +SS      + S         NSA+       G  +  
Sbjct: 352 LRPEAPPPPPPAFSFQEFLPSLNSSPLDIRKKLSGPLPPRLDENSAEPGPWEDPGTGWRW 411

Query: 532 SWTFGMF--SDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPS 589
             T G    SD +S GG SESRSLDS + SPG   R+L +  S+GT SS DD +ER+P  
Sbjct: 412 QGTPGPTPGSDVDSVGGGSESRSLDSPTSSPGAGTRQLVKASSTGTESS-DDFEERDPDL 470

Query: 590 PSETGPNSLGT-FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRK 648
             +   N LG+ F K  +S AA TH+ R+LR P KCR+CE  +V  G ECEEC L CH++
Sbjct: 471 -GDGLENGLGSPFGKWTLSSAAQTHQLRRLRGPAKCRECEAFMV-SGTECEECFLTCHKR 528

Query: 649 CLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRV 708
           CLE L+I+CGH++LP +  LFG +F Q+ +  P+ +PF++  C +EIE+RAL +QGIYRV
Sbjct: 529 CLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRV 588

Query: 709 CGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAK 768
            G++++ E+LCQA ENG  LV++S  S HD+  VLK +L++L EP I F LY  FI LAK
Sbjct: 589 SGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAK 648

Query: 769 EIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRV 828
            +           +  +D   P+   E+ R L   K LL QLP SN+N+L  L+ HL RV
Sbjct: 649 TLH---------ADPGDDPGTPSPSPEVIRSL---KTLLVQLPDSNYNTLRHLVAHLFRV 696

Query: 829 VDHAEENKMNSKNLGVIFGPSLIRPRP---TTAPITISSLAEYSNQARLVEFLITYSQKI 885
                ENKM++ NLG++FGP+L+RP       + I ++ L +  +QA+LVEFLI + ++I
Sbjct: 697 AARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQI 756

Query: 886 FDGSLQPQ 893
           F     PQ
Sbjct: 757 FGMDELPQ 764


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  120 bits (301), Expect = 8e-27
 Identities = 89/302 (29%), Positives = 141/302 (46%), Gaps = 47/302 (15%)

Query: 604 TLMSKAALTH-------------KFRKLRSPTKCRDCEGIV---VFQGVECEECLLVCHR 647
           +L+ +AALTH             K    R P  C  C   +   + QGV C +C L  H+
Sbjct: 195 SLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHK 254

Query: 648 KCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYR 707
           +C +++   C    L     ++  + T + K      P ++ IC  EIE R L  +G+YR
Sbjct: 255 QCSKHVPNDC-QPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYR 313

Query: 708 VCGNKIKTEKLCQALENGMHLVDISEFSSHDI---CDVLKLYLRQLPEPFILFRLYKEFI 764
           V G     E +  A +      DIS     DI      LKLY R LP P I +  Y +FI
Sbjct: 314 VSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFI 373

Query: 765 DLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVH 824
           D AK I + +E  E                          ++L  LP +++ +L +L++H
Sbjct: 374 DAAK-ISNADERLEAVH-----------------------EVLMLLPPAHYETLRYLMIH 409

Query: 825 LKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQK 884
           LK+V  + ++N MN++NLG++FGP+L+RP   +   T+++L +   Q  +V+ LI     
Sbjct: 410 LKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDS---TLTTLHDMRYQKLIVQILIENEDV 466

Query: 885 IF 886
           +F
Sbjct: 467 LF 468


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  120 bits (301), Expect = 8e-27
 Identities = 89/302 (29%), Positives = 141/302 (46%), Gaps = 47/302 (15%)

Query: 604 TLMSKAALTH-------------KFRKLRSPTKCRDCEGIV---VFQGVECEECLLVCHR 647
           +L+ +AALTH             K    R P  C  C   +   + QGV C +C L  H+
Sbjct: 59  SLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHK 118

Query: 648 KCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYR 707
           +C +++   C    L     ++  + T + K      P ++ IC  EIE R L  +G+YR
Sbjct: 119 QCSKHVPNDC-QPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYR 177

Query: 708 VCGNKIKTEKLCQALENGMHLVDISEFSSHDI---CDVLKLYLRQLPEPFILFRLYKEFI 764
           V G     E +  A +      DIS     DI      LKLY R LP P I +  Y +FI
Sbjct: 178 VSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFI 237

Query: 765 DLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVH 824
           D AK I + +E  E                          ++L  LP +++ +L +L++H
Sbjct: 238 DAAK-ISNADERLEAVH-----------------------EVLMLLPPAHYETLRYLMIH 273

Query: 825 LKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQK 884
           LK+V  + ++N MN++NLG++FGP+L+RP   +   T+++L +   Q  +V+ LI     
Sbjct: 274 LKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDS---TLTTLHDMRYQKLIVQILIENEDV 330

Query: 885 IF 886
           +F
Sbjct: 331 LF 332


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score =  115 bits (289), Expect = 2e-25
 Identities = 85/279 (30%), Positives = 130/279 (46%), Gaps = 34/279 (12%)

Query: 614 KFRKLRSPTKCRDCEGIV---VFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFG 670
           K    R P  C  C   +   + QGV+C +C L  H++C + +   C    L     ++ 
Sbjct: 209 KVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDC-KPDLKHVKKVYS 267

Query: 671 AEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVD 730
            + T + K      P ++ +C  EIE+R L  +G+YRV G     E +  A +      D
Sbjct: 268 CDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKAD 327

Query: 731 ISEFSSHD---ICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDK 787
           IS     D   I   LKLY R LP P I +  Y +FI+ AK I   +E+ ET        
Sbjct: 328 ISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAK-IMDPDEQLET-------- 378

Query: 788 KWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFG 847
                            + L+ LP ++  +L +L+ HLKRV  H +EN MN++NLG++FG
Sbjct: 379 ---------------LHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFG 423

Query: 848 PSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIF 886
           P+L+R     A   +++L +   Q  +VE LI     +F
Sbjct: 424 PTLMRSPELDA---MAALNDIRYQRLVVELLIKNEDILF 459


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score =  114 bits (286), Expect = 4e-25
 Identities = 84/274 (30%), Positives = 129/274 (47%), Gaps = 34/274 (12%)

Query: 619 RSPTKCRDCEGIV---VFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQ 675
           R P  C  C   +   + QGV+C +C L  H++C + +   C    L     ++  + T 
Sbjct: 188 RGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDC-KPDLKHVKKVYSCDLTT 246

Query: 676 VAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFS 735
           + K      P ++ +C  EIE+R L  +G+YRV G     E +  A +      DIS   
Sbjct: 247 LVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNM 306

Query: 736 SHD---ICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNM 792
             D   I   LKLY R LP P I +  Y +FI+ AK I   +E+ ET             
Sbjct: 307 YEDINIITGALKLYFRDLPIPLITYDAYPKFIESAK-IMDPDEQLET------------- 352

Query: 793 CIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIR 852
                       + L+ LP ++  +L +L+ HLKRV  H +EN MN++NLG++FGP+L+R
Sbjct: 353 ----------LHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMR 402

Query: 853 PRPTTAPITISSLAEYSNQARLVEFLITYSQKIF 886
                A   +++L +   Q  +VE LI     +F
Sbjct: 403 SPELDA---MAALNDIRYQRLVVELLIKNEDILF 433


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score =  108 bits (270), Expect = 3e-23
 Identities = 64/224 (28%), Positives = 112/224 (50%), Gaps = 31/224 (13%)

Query: 665 KIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALEN 724
           K  +FG+    + ++E   +P  +K+C   +E   L + GIYRV GN    +KL  A+ +
Sbjct: 650 KDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNH 709

Query: 725 G--MHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKN 782
              + L D      H I   LK++ R+LPEP   F  + +F++  K+             
Sbjct: 710 DEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQ------------- 756

Query: 783 SLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNL 842
                       E  + +   KDL+RQLP  N +++  L  HL+RV+++ E+N+M  +++
Sbjct: 757 ------------EPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSI 804

Query: 843 GVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIF 886
            ++FGP+L++P   T  I + ++  Y NQ  +VE ++     IF
Sbjct: 805 AIVFGPTLLKPEKETGNIAVHTV--YQNQ--IVELILLELSSIF 844


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score =  103 bits (258), Expect = 8e-22
 Identities = 67/226 (29%), Positives = 116/226 (51%), Gaps = 34/226 (15%)

Query: 665 KIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALEN 724
           K  +FG     + ++E   +P  ++ C   +E R L + G+YR+ GN    +KL   +++
Sbjct: 323 KDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDH 382

Query: 725 GMHL-VDISEFSS-HDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKN 782
              L +D   +   H I   LKL+ R+LPEP   F  +++FI   K              
Sbjct: 383 DERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIK-------------- 428

Query: 783 SLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNL 842
            L+D+   + C+         +DL+R LPA N ++L  L  HL RV++H E+N+M+ +++
Sbjct: 429 -LQDQARRSRCV---------RDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSV 478

Query: 843 GVIFGPSLIRP--RPTTAPITISSLAEYSNQARLVEFLITYSQKIF 886
            ++FGP+L+RP    T+ P+T+     + NQ  +VE ++     IF
Sbjct: 479 AIVFGPTLLRPEVEETSMPMTM----VFQNQ--VVELILQQCADIF 518


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score =  103 bits (258), Expect = 8e-22
 Identities = 67/226 (29%), Positives = 116/226 (51%), Gaps = 34/226 (15%)

Query: 665 KIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALEN 724
           K  +FG     + ++E   +P  ++ C   +E R L + G+YR+ GN    +KL   +++
Sbjct: 350 KDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDH 409

Query: 725 GMHL-VDISEFSS-HDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKN 782
              L +D   +   H I   LKL+ R+LPEP   F  +++FI   K              
Sbjct: 410 DERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIK-------------- 455

Query: 783 SLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNL 842
            L+D+   + C+         +DL+R LPA N ++L  L  HL RV++H E+N+M+ +++
Sbjct: 456 -LQDQARRSRCV---------RDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSV 505

Query: 843 GVIFGPSLIRP--RPTTAPITISSLAEYSNQARLVEFLITYSQKIF 886
            ++FGP+L+RP    T+ P+T+     + NQ  +VE ++     IF
Sbjct: 506 AIVFGPTLLRPEVEETSMPMTM----VFQNQ--VVELILQQCADIF 545


>gi|156119615 myosin IXA [Homo sapiens]
          Length = 2548

 Score =  103 bits (257), Expect = 1e-21
 Identities = 69/274 (25%), Positives = 124/274 (45%), Gaps = 30/274 (10%)

Query: 621  PTKCRDCEGIV--VFQGVECEECLLVCHRKCLENLVIICGHQKLPG-KIHLFGAEFTQVA 677
            PT C  C  ++  + +   C+ C   CH+KC       C  +  P      FG E +++ 
Sbjct: 2010 PTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLT 2069

Query: 678  KKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSH 737
             ++   +P +++   + IE   L  +GIYR  G+  K ++L Q L+     V++ +++ H
Sbjct: 2070 SEDRT-VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIH 2128

Query: 738  DICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEIN 797
             I  V K +LR LP P + F LY+EF+        + E +ET +                
Sbjct: 2129 VIASVFKQWLRDLPNPLMTFELYEEFL----RAMGLQERKETIRGVY------------- 2171

Query: 798  RILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTT 857
                    ++ QL  ++ N+L  LI HL R+    + N+M++  L ++F P ++R   TT
Sbjct: 2172 -------SVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTT 2224

Query: 858  APITISSLAEYSNQARLVEFLITYSQKIFDGSLQ 891
             P  + S+ + S     VE ++      +   L+
Sbjct: 2225 DP--LQSVQDISKTTTCVELIVVEQMNKYKARLK 2256


>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
          Length = 2157

 Score =  100 bits (249), Expect = 9e-21
 Identities = 104/438 (23%), Positives = 175/438 (39%), Gaps = 57/438 (13%)

Query: 621  PTKCRDCEGIV--VFQGVECEECLLVCHRKCLENLVIIC----GHQKLPGKIHLFGAEFT 674
            P  C  C   +  + + + C  C + CH+KC+  +   C    G +  PG          
Sbjct: 1643 PQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCV 1702

Query: 675  QVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEF 734
                 +   +P +L+     +E   L  +G+YR  G   +T +L QAL+     V +  F
Sbjct: 1703 DSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENF 1762

Query: 735  SSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCI 794
              H I  VLK +LR+LPEP + F  Y +F+   +    + E+QE                
Sbjct: 1763 PIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVE----LPEKQEQ--------------- 1803

Query: 795  EINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR 854
                 L     +L  LP +N NSL  LI HL +V    + N+M+   L +IF P L+R  
Sbjct: 1804 -----LAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCP 1858

Query: 855  PTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCS--------IGVVDQGC 906
              + P+T  S+ +       VE LI    + +   ++    + +        + ++ Q  
Sbjct: 1859 DNSDPLT--SMKDVLKITTCVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNA 1916

Query: 907  FPKPL----LSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNALGK 962
             P PL     SP E  + +S K+       DI   E E  + E A   +E   K+  + +
Sbjct: 1917 -PWPLKLGFSSPYEGVLNKSPKT------RDIQEEELEVLLEEEAAGGDEDREKEILIER 1969

Query: 963  CDACLSDKAQL---LLDQEAESASQKIEDGKTPKPL-SLKSDRSTNNVERHTPRTKIRPV 1018
              +   +K  +   L + +   + ++  D +T     SL  +R+        P   +   
Sbjct: 1970 IQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESLLEERAGRGASEGPPAPALPCP 2029

Query: 1019 SLPVDRLL--LASPPNER 1034
              P    L  +A+PP  R
Sbjct: 2030 GAPTPSPLPTVAAPPRRR 2047



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 30/124 (24%), Positives = 47/124 (37%), Gaps = 8/124 (6%)

Query: 1132 VRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVP 1191
            V  + +  E R  ++  +    A  T Q Q      +P A  +     E +   PS +  
Sbjct: 1188 VSLLEDKKESREDETLLVVETEAENTSQKQPTE---QPQAMAVGKVSEETEKTLPSGSPR 1244

Query: 1192 PGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRP-RLKRMQQF 1250
            PG    P  L + S   P      PG A   P++ S+  G P V      P    ++Q++
Sbjct: 1245 PGQLERPTSLALDSRVSP----PAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRY 1300

Query: 1251 EDLE 1254
             D E
Sbjct: 1301 LDAE 1304


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score =  100 bits (248), Expect = 1e-20
 Identities = 62/224 (27%), Positives = 115/224 (51%), Gaps = 30/224 (13%)

Query: 665 KIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQAL-- 722
           K  +FG+   +V ++E   +P+ +K C   +E R L + GIYRV GN    +KL   +  
Sbjct: 275 KDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQ 334

Query: 723 ENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKN 782
           E  ++L D      H +   LK++ R+LPEP   +  +++F++  K+     ++  T+  
Sbjct: 335 EEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKK-----QDNNTRIE 389

Query: 783 SLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNL 842
           ++                   K L+++LP  N +++  L  HL ++V  A +N M++++L
Sbjct: 390 AV-------------------KSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSL 430

Query: 843 GVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIF 886
           G++FGP+L+R    T  + I  +  Y NQ  + E +++   KIF
Sbjct: 431 GIVFGPTLLRAENETGNMAIHMV--YQNQ--IAELMLSEYSKIF 470


>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
          Length = 2022

 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 91/371 (24%), Positives = 151/371 (40%), Gaps = 51/371 (13%)

Query: 621  PTKCRDCEGIV--VFQGVECEECLLVCHRKCLENLVIIC----GHQKLPGKIHLFGAEFT 674
            P  C  C   +  + + + C  C + CH+KC+  +   C    G +  PG          
Sbjct: 1643 PQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCV 1702

Query: 675  QVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEF 734
                 +   +P +L+     +E   L  +G+YR  G   +T +L QAL+     V +  F
Sbjct: 1703 DSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENF 1762

Query: 735  SSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCI 794
              H I  VLK +LR+LPEP + F  Y +F+   +    + E+QE                
Sbjct: 1763 PIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVE----LPEKQEQ--------------- 1803

Query: 795  EINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPR 854
                 L     +L  LP +N NSL  LI HL +V    + N+M+   L +IF P L+R  
Sbjct: 1804 -----LAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCP 1858

Query: 855  PTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCS--------IGVVDQGC 906
              + P+T  S+ +       VE LI    + +   ++    + +        + ++ Q  
Sbjct: 1859 DNSDPLT--SMKDVLKITTCVEMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNA 1916

Query: 907  FPKPL----LSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNALGK 962
             P PL     SP E  + +S K+       DI   E E  + E A   +E   K+  + +
Sbjct: 1917 -PWPLKLGFSSPYEGVLNKSPKT------RDIQEEELEVLLEEEAAGGDEDREKEILIER 1969

Query: 963  CDACLSDKAQL 973
              +   +K  +
Sbjct: 1970 IQSIKEEKEDI 1980



 Score = 31.6 bits (70), Expect = 5.0
 Identities = 30/124 (24%), Positives = 47/124 (37%), Gaps = 8/124 (6%)

Query: 1132 VRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVP 1191
            V  + +  E R  ++  +    A  T Q Q      +P A  +     E +   PS +  
Sbjct: 1188 VSLLEDKKESREDETLLVVETEAENTSQKQPTE---QPQAMAVGKVSEETEKTLPSGSPR 1244

Query: 1192 PGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRP-RLKRMQQF 1250
            PG    P  L + S   P      PG A   P++ S+  G P V      P    ++Q++
Sbjct: 1245 PGQLERPTSLALDSRVSP----PAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRY 1300

Query: 1251 EDLE 1254
             D E
Sbjct: 1301 LDAE 1304


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 64/202 (31%), Positives = 97/202 (48%), Gaps = 26/202 (12%)

Query: 668 LFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCG--NKIKTEKLCQALENG 725
           +FG + + V K+E   +P+I++ C  E+E R +   GIYR+ G    I+  K      N 
Sbjct: 598 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 657

Query: 726 MHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLE 785
             L+ +S+   + I   LKLY R+LPEP +  RLY  F++                 +L 
Sbjct: 658 DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGI---------------ALS 702

Query: 786 DKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVI 845
           D      C+           LLR LP  N  +  FL+ HLKRV +    NKM+  NL  +
Sbjct: 703 DPAAKENCM---------MHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 753

Query: 846 FGPSLIRPRPTTAPITISSLAE 867
           FGP+L+RP    +   ++S A+
Sbjct: 754 FGPTLLRPSEVESKAHLTSAAD 775


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 64/202 (31%), Positives = 97/202 (48%), Gaps = 26/202 (12%)

Query: 668 LFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCG--NKIKTEKLCQALENG 725
           +FG + + V K+E   +P+I++ C  E+E R +   GIYR+ G    I+  K      N 
Sbjct: 644 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 703

Query: 726 MHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLE 785
             L+ +S+   + I   LKLY R+LPEP +  RLY  F++                 +L 
Sbjct: 704 DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGI---------------ALS 748

Query: 786 DKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVI 845
           D      C+           LLR LP  N  +  FL+ HLKRV +    NKM+  NL  +
Sbjct: 749 DPAAKENCM---------MHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 799

Query: 846 FGPSLIRPRPTTAPITISSLAE 867
           FGP+L+RP    +   ++S A+
Sbjct: 800 FGPTLLRPSEVESKAHLTSAAD 821


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 64/202 (31%), Positives = 97/202 (48%), Gaps = 26/202 (12%)

Query: 668 LFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCG--NKIKTEKLCQALENG 725
           +FG + + V K+E   +P+I++ C  E+E R +   GIYR+ G    I+  K      N 
Sbjct: 607 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 666

Query: 726 MHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLE 785
             L+ +S+   + I   LKLY R+LPEP +  RLY  F++                 +L 
Sbjct: 667 DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGI---------------ALS 711

Query: 786 DKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVI 845
           D      C+           LLR LP  N  +  FL+ HLKRV +    NKM+  NL  +
Sbjct: 712 DPAAKENCM---------MHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 762

Query: 846 FGPSLIRPRPTTAPITISSLAE 867
           FGP+L+RP    +   ++S A+
Sbjct: 763 FGPTLLRPSEVESKAHLTSAAD 784


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 70/230 (30%), Positives = 106/230 (46%), Gaps = 32/230 (13%)

Query: 684  IPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHD---IC 740
            IP I+ IC   +E R L   GIYRV GN      + + L  GM  +DI +    D   I 
Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220

Query: 741  DVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRIL 800
             +LK + R+LPEP      Y +FI           E   K++ L+  K            
Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFI-----------EANRKEDPLDRLK------------ 1257

Query: 801  LKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPI 860
               K L+  LP  ++ +L FL  HLK V +++E+NKM  +NL ++FGP+L+R   T+   
Sbjct: 1258 -TLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVR---TSEDN 1313

Query: 861  TISSLAEYSNQARLVEFLITYSQKIF--DGSLQPQDVMCSIGVVDQGCFP 908
                +    +Q ++VE LI +    F  +G+ +P   +     VD    P
Sbjct: 1314 MTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVP 1363


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 63/210 (30%), Positives = 97/210 (46%), Gaps = 30/210 (14%)

Query: 680  EPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHD- 738
            E   +P I+  C   +E R L   GIYRV GN      L + L  G   +++ +    D 
Sbjct: 821  ENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDL 880

Query: 739  --ICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEI 796
              I  +LK + R+LPEP      Y +FI+ A  I+   E   T +               
Sbjct: 881  NVISSLLKSFFRKLPEPLFTDDKYNDFIE-ANRIEDARERMRTLRK-------------- 925

Query: 797  NRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPT 856
                     L+R LP   + +L FL+ HLK + DH+E+NKM  +NL ++FGP+L+R   T
Sbjct: 926  ---------LIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVR---T 973

Query: 857  TAPITISSLAEYSNQARLVEFLITYSQKIF 886
            +       +    ++ ++VE LI +S   F
Sbjct: 974  SEDNMTDMVTHMPDRYKIVETLIQHSDWFF 1003


>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
          Length = 786

 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 65/205 (31%), Positives = 103/205 (50%), Gaps = 33/205 (16%)

Query: 687 ILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALE-----NGMHLVDISEFSSHDICD 741
           I++ C S +E R +  QG+YRV G   K ++L   L      N + L + +++    I  
Sbjct: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457

Query: 742 VLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILL 801
            LK YLR LPEP + + L+ +FI  AK     +   E++ N++                 
Sbjct: 458 ALKQYLRSLPEPLMTYELHGDFIVPAK-----SGSPESRVNAIHF--------------- 497

Query: 802 KSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPIT 861
               L+ +LP  N   L  L+ HL  V +H+++N M   NLGV+FGP+L+RP+      T
Sbjct: 498 ----LVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEE----T 549

Query: 862 ISSLAEYSNQARLVEFLITYSQKIF 886
           +++L +   Q  +VE LI   +KIF
Sbjct: 550 VAALMDLKFQNIVVEILIENHEKIF 574


>gi|186910302 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 138/634 (21%), Positives = 258/634 (40%), Gaps = 98/634 (15%)

Query: 372 RRLEEEALQKVE---EANELYKVCVT-NVEERRNDLENTKREILAQLRTLVFQCDLTLKA 427
           R L E+ +++VE   E NE+  + +  + E+ R   + T  E L + + L+ + +    A
Sbjct: 9   RNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHE-LGKYKDLLMKAETERSA 67

Query: 428 VTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNS-----TEEEKVDGNV 482
           + V L H ++     +    ++  D  KL    Q   E +    S     +EE+K   + 
Sbjct: 68  LDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQK---SA 124

Query: 483 NKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADIT---GPSFIRSWTFGMFS 539
              LN  QPS     N     +   D S  I  D   +  D +     S ++++      
Sbjct: 125 LAFLNRGQPSSSNAGNKRLSTI---DESGSILSDISFDKTDESLDWDSSLVKTFKLKKRE 181

Query: 540 DSEST---------GGSSESRSLDS------ESIS-------PGD--------------- 562
              ST         G   ++RS+ S      ESI        P D               
Sbjct: 182 KRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVPY 241

Query: 563 FHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKF--RKLRS 620
           + R   +T +    +S   L+ R+    +ET  +S+GT +    +     H F  + +  
Sbjct: 242 WTRSRRKTGTLQPWNSDSTLNSRQLEPRTET--DSVGTPQS---NGGMRLHDFVSKTVIK 296

Query: 621 PTKCRDCEGIVVFQ--GVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAK 678
           P  C  C   + F    ++C +C +V H +C +   + C    +   + +          
Sbjct: 297 PESCVPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPTLIGTPVKIGEGMLADFVS 356

Query: 679 KEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSS-H 737
           +    IP I+  C +EIE R L   G+YR+ G     ++L +       +  +S+    H
Sbjct: 357 QTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSKVDDIH 416

Query: 738 DICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEIN 797
            IC +LK +LR L EP + FRL + F++ A+    + +E  +                  
Sbjct: 417 AICSLLKDFLRNLKEPLLTFRLNRAFMEAAE----ITDEDNS------------------ 454

Query: 798 RILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLI-RPRPT 856
             +      + +LP +N ++L FL++HL+RV   +   KM+  NL  +FGP+++    P 
Sbjct: 455 --IAAMYQAVGELPQANRDTLAFLMIHLQRVA-QSPHTKMDVANLAKVFGPTIVAHAVPN 511

Query: 857 TAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQ-PQDVMCSIGVVDQGCFPKPLLSPE 915
             P+T+  L +   Q ++VE L++   + +   +   Q+ +  + V++         +P+
Sbjct: 512 PDPVTM--LQDIKRQPKVVERLLSLPLEYWSQFMMVEQENIDPLHVIENS---NAFSTPQ 566

Query: 916 ERDIERSMKSLFFSSKEDIHTSESESKIFERATS 949
             DI+ S+     + +  +  + S S + +R  S
Sbjct: 567 TPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRS 600


>gi|186910300 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 138/634 (21%), Positives = 258/634 (40%), Gaps = 98/634 (15%)

Query: 372 RRLEEEALQKVE---EANELYKVCVT-NVEERRNDLENTKREILAQLRTLVFQCDLTLKA 427
           R L E+ +++VE   E NE+  + +  + E+ R   + T  E L + + L+ + +    A
Sbjct: 9   RNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHE-LGKYKDLLMKAETERSA 67

Query: 428 VTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNS-----TEEEKVDGNV 482
           + V L H ++     +    ++  D  KL    Q   E +    S     +EE+K   + 
Sbjct: 68  LDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQK---SA 124

Query: 483 NKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADIT---GPSFIRSWTFGMFS 539
              LN  QPS     N     +   D S  I  D   +  D +     S ++++      
Sbjct: 125 LAFLNRGQPSSSNAGNKRLSTI---DESGSILSDISFDKTDESLDWDSSLVKTFKLKKRE 181

Query: 540 DSEST---------GGSSESRSLDS------ESIS-------PGD--------------- 562
              ST         G   ++RS+ S      ESI        P D               
Sbjct: 182 KRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVPY 241

Query: 563 FHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKF--RKLRS 620
           + R   +T +    +S   L+ R+    +ET  +S+GT +    +     H F  + +  
Sbjct: 242 WTRSRRKTGTLQPWNSDSTLNSRQLEPRTET--DSVGTPQS---NGGMRLHDFVSKTVIK 296

Query: 621 PTKCRDCEGIVVFQ--GVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAK 678
           P  C  C   + F    ++C +C +V H +C +   + C    +   + +          
Sbjct: 297 PESCVPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPTLIGTPVKIGEGMLADFVS 356

Query: 679 KEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSS-H 737
           +    IP I+  C +EIE R L   G+YR+ G     ++L +       +  +S+    H
Sbjct: 357 QTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSKVDDIH 416

Query: 738 DICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEIN 797
            IC +LK +LR L EP + FRL + F++ A+    + +E  +                  
Sbjct: 417 AICSLLKDFLRNLKEPLLTFRLNRAFMEAAE----ITDEDNS------------------ 454

Query: 798 RILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLI-RPRPT 856
             +      + +LP +N ++L FL++HL+RV   +   KM+  NL  +FGP+++    P 
Sbjct: 455 --IAAMYQAVGELPQANRDTLAFLMIHLQRVA-QSPHTKMDVANLAKVFGPTIVAHAVPN 511

Query: 857 TAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQ-PQDVMCSIGVVDQGCFPKPLLSPE 915
             P+T+  L +   Q ++VE L++   + +   +   Q+ +  + V++         +P+
Sbjct: 512 PDPVTM--LQDIKRQPKVVERLLSLPLEYWSQFMMVEQENIDPLHVIENS---NAFSTPQ 566

Query: 916 ERDIERSMKSLFFSSKEDIHTSESESKIFERATS 949
             DI+ S+     + +  +  + S S + +R  S
Sbjct: 567 TPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRS 600


>gi|21361397 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 138/634 (21%), Positives = 258/634 (40%), Gaps = 98/634 (15%)

Query: 372 RRLEEEALQKVE---EANELYKVCVT-NVEERRNDLENTKREILAQLRTLVFQCDLTLKA 427
           R L E+ +++VE   E NE+  + +  + E+ R   + T  E L + + L+ + +    A
Sbjct: 9   RNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHE-LGKYKDLLMKAETERSA 67

Query: 428 VTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNS-----TEEEKVDGNV 482
           + V L H ++     +    ++  D  KL    Q   E +    S     +EE+K   + 
Sbjct: 68  LDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEEQK---SA 124

Query: 483 NKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADIT---GPSFIRSWTFGMFS 539
              LN  QPS     N     +   D S  I  D   +  D +     S ++++      
Sbjct: 125 LAFLNRGQPSSSNAGNKRLSTI---DESGSILSDISFDKTDESLDWDSSLVKTFKLKKRE 181

Query: 540 DSEST---------GGSSESRSLDS------ESIS-------PGD--------------- 562
              ST         G   ++RS+ S      ESI        P D               
Sbjct: 182 KRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVPY 241

Query: 563 FHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKF--RKLRS 620
           + R   +T +    +S   L+ R+    +ET  +S+GT +    +     H F  + +  
Sbjct: 242 WTRSRRKTGTLQPWNSDSTLNSRQLEPRTET--DSVGTPQS---NGGMRLHDFVSKTVIK 296

Query: 621 PTKCRDCEGIVVFQ--GVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAK 678
           P  C  C   + F    ++C +C +V H +C +   + C    +   + +          
Sbjct: 297 PESCVPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPTLIGTPVKIGEGMLADFVS 356

Query: 679 KEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSS-H 737
           +    IP I+  C +EIE R L   G+YR+ G     ++L +       +  +S+    H
Sbjct: 357 QTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSKVDDIH 416

Query: 738 DICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEIN 797
            IC +LK +LR L EP + FRL + F++ A+    + +E  +                  
Sbjct: 417 AICSLLKDFLRNLKEPLLTFRLNRAFMEAAE----ITDEDNS------------------ 454

Query: 798 RILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLI-RPRPT 856
             +      + +LP +N ++L FL++HL+RV   +   KM+  NL  +FGP+++    P 
Sbjct: 455 --IAAMYQAVGELPQANRDTLAFLMIHLQRVA-QSPHTKMDVANLAKVFGPTIVAHAVPN 511

Query: 857 TAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQ-PQDVMCSIGVVDQGCFPKPLLSPE 915
             P+T+  L +   Q ++VE L++   + +   +   Q+ +  + V++         +P+
Sbjct: 512 PDPVTM--LQDIKRQPKVVERLLSLPLEYWSQFMMVEQENIDPLHVIENS---NAFSTPQ 566

Query: 916 ERDIERSMKSLFFSSKEDIHTSESESKIFERATS 949
             DI+ S+     + +  +  + S S + +R  S
Sbjct: 567 TPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRS 600


>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
           sapiens]
          Length = 731

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 65/242 (26%), Positives = 115/242 (47%), Gaps = 54/242 (22%)

Query: 668 LFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLC-------- 719
           +FG +   + ++E D +P  L++C + ++ R L + GIYRV GN    +KL         
Sbjct: 520 VFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERA 579

Query: 720 -----------QALENGMHLVDISEFSS-HDICDVLKLYLRQLPEPFI---LFRLYKEFI 764
                      Q  + G   +D +E+   H +   LKL+LR+LP+P +   L   ++  +
Sbjct: 580 VTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAAL 639

Query: 765 DLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVH 824
            L++  Q +++ QE                           L+  +P  N ++L +L+ H
Sbjct: 640 ALSESEQCLSQIQE---------------------------LIGSMPKPNHDTLRYLLEH 672

Query: 825 LKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQK 884
           L RV+ H+++N+M   NLG++FGP+L RP   T+     +L  Y  Q  LV+ ++T    
Sbjct: 673 LCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHAL--YPGQ--LVQLMLTNFTS 728

Query: 885 IF 886
           +F
Sbjct: 729 LF 730


>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
           sapiens]
          Length = 547

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 65/242 (26%), Positives = 115/242 (47%), Gaps = 54/242 (22%)

Query: 668 LFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLC-------- 719
           +FG +   + ++E D +P  L++C + ++ R L + GIYRV GN    +KL         
Sbjct: 336 VFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERA 395

Query: 720 -----------QALENGMHLVDISEFSS-HDICDVLKLYLRQLPEPFI---LFRLYKEFI 764
                      Q  + G   +D +E+   H +   LKL+LR+LP+P +   L   ++  +
Sbjct: 396 VTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAAL 455

Query: 765 DLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVH 824
            L++  Q +++ QE                           L+  +P  N ++L +L+ H
Sbjct: 456 ALSESEQCLSQIQE---------------------------LIGSMPKPNHDTLRYLLEH 488

Query: 825 LKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQK 884
           L RV+ H+++N+M   NLG++FGP+L RP   T+     +L  Y  Q  LV+ ++T    
Sbjct: 489 LCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHAL--YPGQ--LVQLMLTNFTS 544

Query: 885 IF 886
           +F
Sbjct: 545 LF 546


>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
           sapiens]
          Length = 890

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 63/242 (26%), Positives = 118/242 (48%), Gaps = 40/242 (16%)

Query: 658 GHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEK 717
           G +K   K  +FG +  +  +     +P +LK CA  +E   + + GIYR+ G     +K
Sbjct: 7   GKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQK 65

Query: 718 LCQALEN--------GMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKE 769
           L Q  E+         ++L DI     H +  + K Y R+LP+P + +RLY +F +    
Sbjct: 66  LRQEFESERKPDLRRDVYLQDI-----HCVSSLCKAYFRELPDPLLTYRLYDKFAEA--- 117

Query: 770 IQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVV 829
              V  + E ++                  L+K  ++LR+LP  N+ +L FL+ HL  + 
Sbjct: 118 ---VGVQLEPER------------------LVKILEVLRELPVPNYRTLEFLMRHLVHMA 156

Query: 830 DHAEENKMNSKNLGVIFGPSLIRPRPTTAP--ITISSLAEYSNQARLVEFLITYSQKIFD 887
             + +  M+++NL +++ P+L+R +   A      ++  E   Q+ +VEF++T+  ++F 
Sbjct: 157 SFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFG 216

Query: 888 GS 889
           G+
Sbjct: 217 GA 218


>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
           sapiens]
          Length = 1101

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 63/242 (26%), Positives = 118/242 (48%), Gaps = 40/242 (16%)

Query: 658 GHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEK 717
           G +K   K  +FG +  +  +     +P +LK CA  +E   + + GIYR+ G     +K
Sbjct: 7   GKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQK 65

Query: 718 LCQALEN--------GMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKE 769
           L Q  E+         ++L DI     H +  + K Y R+LP+P + +RLY +F +    
Sbjct: 66  LRQEFESERKPDLRRDVYLQDI-----HCVSSLCKAYFRELPDPLLTYRLYDKFAEA--- 117

Query: 770 IQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVV 829
              V  + E ++                  L+K  ++LR+LP  N+ +L FL+ HL  + 
Sbjct: 118 ---VGVQLEPER------------------LVKILEVLRELPVPNYRTLEFLMRHLVHMA 156

Query: 830 DHAEENKMNSKNLGVIFGPSLIRPRPTTAP--ITISSLAEYSNQARLVEFLITYSQKIFD 887
             + +  M+++NL +++ P+L+R +   A      ++  E   Q+ +VEF++T+  ++F 
Sbjct: 157 SFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFG 216

Query: 888 GS 889
           G+
Sbjct: 217 GA 218


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 78/324 (24%), Positives = 149/324 (45%), Gaps = 54/324 (16%)

Query: 661 KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKL-- 718
           K  G    FG + T+  +     +P++LK CA  IE   + + GIYR+ G     ++L  
Sbjct: 11  KRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQ 69

Query: 719 ------CQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQH 772
                 C  L   ++L DI     H +  + KLY R+LP P + + LY++F +    + H
Sbjct: 70  EFGSDQCPDLTREVYLQDI-----HCVGSLCKLYFRELPNPLLTYELYEKFTEA---VSH 121

Query: 773 VNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHA 832
             EE +                     L + ++++++LP S++ +L +LI HL  +   +
Sbjct: 122 CPEEGQ---------------------LARIQNVIQELPPSHYRTLEYLIRHLAHIASFS 160

Query: 833 EENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQAR--LVEFLITYSQKIFD--- 887
            +  M+++NL +++ P+L+R +   A       A  + + +  ++EF++ +  +IF+   
Sbjct: 161 SKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGA 220

Query: 888 -GSLQPQD---VMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESE--- 940
            GSL+  +   +M S+  +     P  L+S EE    RS+ +   + KE    S  E   
Sbjct: 221 PGSLENDENRPIMKSL-TLPALSLPMKLVSLEEAQ-ARSLATNHPARKERRENSLPEIVP 278

Query: 941 --SKIFERATSFEESERKQNALGK 962
               +F       +++RK ++  K
Sbjct: 279 PMGTLFHTVLELPDNKRKLSSKSK 302


>gi|4505507 oligophrenin 1 [Homo sapiens]
          Length = 802

 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 67/234 (28%), Positives = 112/234 (47%), Gaps = 33/234 (14%)

Query: 660 QKLPGKIHLFGAEFTQVAKKEPDGIPF-ILKICASEIENRALCLQGIYRVCGNKIKTEKL 718
           + + GK  ++ +  T+  + E + + F  ++ C + IE + +  +G+YR  G+ I+ +KL
Sbjct: 361 EAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKL 420

Query: 719 CQALENGMHLVDI----SEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVN 774
             A  +     D+    S++    I   LK YLR L EP + +RL+KE +  AK      
Sbjct: 421 LNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKS----- 475

Query: 775 EEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEE 834
                           N+   +  I      L+ +LP  N   L  LI HL  V +H++E
Sbjct: 476 ---------------DNLDYRLGAI----HSLVYKLPEKNREMLELLIRHLVNVCEHSKE 516

Query: 835 NKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDG 888
           N M   N+GVIFGP+L+R +      T++++     Q  +VE LI +  KI+ G
Sbjct: 517 NLMTPSNMGVIFGPTLMRAQED----TVAAMMNIKFQNIVVEILIEHFGKIYLG 566



 Score = 35.0 bits (79), Expect = 0.45
 Identities = 46/204 (22%), Positives = 87/204 (42%), Gaps = 11/204 (5%)

Query: 245 EATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQR 304
           E  RTN  I++ +   +   +A+ N   +     QT+ + Q +     L   +  + +  
Sbjct: 28  ELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESF 87

Query: 305 KEIKELWKQEQNKML----EAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL 360
           KE  EL  + +N+ +     A + L K      + Q  + K +   F  + E   S   L
Sbjct: 88  KEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSL--L 145

Query: 361 AKNLNKQLEKKR-RLEEEALQKVEEANELYKVCVTNVEERRNDLENTK----REILAQLR 415
            ++L+   +KK  +L+E  LQ  +E +  ++  +  V + +   E+ K      +LA L 
Sbjct: 146 DRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLH 205

Query: 416 TLVFQCDLTLKAVTVNLFHMQHLQ 439
           +L     LT++     L + Q LQ
Sbjct: 206 SLFISNSLTVELTQDFLPYKQQLQ 229


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score = 90.5 bits (223), Expect = 9e-18
 Identities = 62/188 (32%), Positives = 87/188 (46%), Gaps = 26/188 (13%)

Query: 668  LFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCG--NKIKTEKLCQALENG 725
            +FG +   V K+E   +P+I++ C  EIE R +   GIYRV G    I+  K    + N 
Sbjct: 1007 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1066

Query: 726  MHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLE 785
               V +SE   + I   LKLY R+LPEP      Y  F                +  +L 
Sbjct: 1067 DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNF---------------AEGIALS 1111

Query: 786  DKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVI 845
            D      C+          +LL  LP +N  +  FL+ HLKRV +    NKM+  NL  +
Sbjct: 1112 DPVAKESCM---------LNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATV 1162

Query: 846  FGPSLIRP 853
            FGP+L+RP
Sbjct: 1163 FGPTLLRP 1170


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,107,528
Number of Sequences: 37866
Number of extensions: 2330547
Number of successful extensions: 10721
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 553
Number of HSP's that attempted gapping in prelim test: 8185
Number of HSP's gapped (non-prelim): 2458
length of query: 1261
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1147
effective length of database: 13,930,794
effective search space: 15978620718
effective search space used: 15978620718
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.