Search of human proteins with 134152725

Search of human proteins with 134152725

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
         (937 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso...  1939   0.0  
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec...  1070   0.0  
gi|134152686 receptor tyrosine kinase-like orphan receptor 1 iso...   821   0.0  
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    302   1e-81
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   254   3e-67
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   254   3e-67
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   251   2e-66
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   251   2e-66
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   251   2e-66
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   247   4e-65
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   237   3e-62
gi|62420886 discoidin domain receptor family, member 2 precursor...   211   3e-54
gi|62420884 discoidin domain receptor family, member 2 precursor...   211   3e-54
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 210   4e-54
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   210   6e-54
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]             208   2e-53
gi|38327632 discoidin domain receptor family, member 1 isoform b...   208   2e-53
gi|83977450 discoidin domain receptor family, member 1 isoform a...   208   2e-53
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   206   8e-53
gi|221316650 ephrin receptor EphA1 [Homo sapiens]                     204   3e-52
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]   204   4e-52
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]   204   4e-52
gi|32528301 EPH receptor B4 precursor [Homo sapiens]                  204   4e-52
gi|83977452 discoidin domain receptor family, member 1 isoform c...   202   9e-52
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs...   202   9e-52
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs...   202   9e-52
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap...   201   2e-51
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi...   201   2e-51
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   201   3e-51
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   201   3e-51

>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
           isoform 1 [Homo sapiens]
          Length = 937

 Score = 1939 bits (5023), Expect = 0.0
 Identities = 937/937 (100%), Positives = 937/937 (100%)

Query: 1   MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL 60
           MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL
Sbjct: 1   MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL 60

Query: 61  DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN 120
           DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN
Sbjct: 61  DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN 120

Query: 121 LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR 180
           LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR
Sbjct: 121 LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR 180

Query: 181 FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS 240
           FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS
Sbjct: 181 FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS 240

Query: 241 VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG 300
           VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG
Sbjct: 241 VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG 300

Query: 301 IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS 360
           IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS
Sbjct: 301 IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS 360

Query: 361 YCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAL 420
           YCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAL
Sbjct: 361 YCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAL 420

Query: 421 LFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELG 480
           LFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELG
Sbjct: 421 LFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELG 480

Query: 481 ECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLG 540
           ECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLG
Sbjct: 481 ECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLG 540

Query: 541 AVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIA 600
           AVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIA
Sbjct: 541 AVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIA 600

Query: 601 AGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMP 660
           AGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMP
Sbjct: 601 AGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMP 660

Query: 661 PEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPR 720
           PEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPR
Sbjct: 661 PEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPR 720

Query: 721 MYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSN 780
           MYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSN
Sbjct: 721 MYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSN 780

Query: 781 LSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTG 840
           LSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTG
Sbjct: 781 LSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTG 840

Query: 841 PPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGIT 900
           PPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGIT
Sbjct: 841 PPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGIT 900

Query: 901 VFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL 937
           VFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL
Sbjct: 901 VFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL 937


>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
           precursor [Homo sapiens]
          Length = 943

 Score = 1070 bits (2766), Expect = 0.0
 Identities = 531/884 (60%), Positives = 656/884 (74%), Gaps = 20/884 (2%)

Query: 4   PRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEP 63
           PRR     P +   AALLL+    + +   L  +  L P    +      K  +L   EP
Sbjct: 8   PRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEP 67

Query: 64  MNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDT 123
           +NNIT   GQTA LHCKV+GNPPP +RW KNDAPVVQEPRR+  R T YGSRLRI++LDT
Sbjct: 68  VNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDT 127

Query: 124 TDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIG 183
           TDTGY+QCVATNG + +++TGVLFV+ GP  + +  + D+Y EDGFCQPYRGIACARFIG
Sbjct: 128 TDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIG 187

Query: 184 NRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPK 243
           NRT+Y++SL MQGEIEN+ITAAFTMIGTS+HLSD+CSQFAIPS CH+ FP CD  S  PK
Sbjct: 188 NRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPK 247

Query: 244 PRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPM 303
           PR+LCRDECE+LE+ LC+ EY  ARSNP+ILMRL+LP CE LP PESP+AANC+RIGIP 
Sbjct: 248 PRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIP- 306

Query: 304 ADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCR 363
           A+ + + H+CYN +G+DYRGT S TKSG QCQPW  Q+PH+H  ++  FPEL GGH+YCR
Sbjct: 307 AERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCR 366

Query: 364 NPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFF 423
           NPG Q E PWCFT ++N + +LCD+P+C  +DS   +KM ILYILVPS+AIPL IA LFF
Sbjct: 367 NPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDS---SKMGILYILVPSIAIPLVIACLFF 423

Query: 424 FICVCRNNQK-SSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGEC 482
            +C+CRN QK S+S P +RQ      Q++EM ++N +K ++K KE+ LSAVRFMEELGE 
Sbjct: 424 LVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHK-QAKLKEISLSAVRFMEELGED 482

Query: 483 AFGKIYKGHLYLPGM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGA 541
            FGK+YKGHL+ P   +  Q VAIKTLKD        EF+ EA L A L HPN+VCLLG 
Sbjct: 483 RFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGV 542

Query: 542 VTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAA 601
           VT++QP+ M+F Y + GDLHEFL+MRSPHSDVG S+D+D TVKS+L+  DF+H+  QIAA
Sbjct: 543 VTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVG-STDDDRTVKSALEPPDFVHLVAQIAA 601

Query: 602 GMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPP 661
           GMEYLSSH  VHKDLA RN+L+ ++L+VKISDLGL RE+Y+ADYY++   SLLPIRWM P
Sbjct: 602 GMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAP 661

Query: 662 EAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRM 721
           EAIMYGKFS DSDIWS+GVVLWE+FS+GLQPY G+SNQ+V+EM+R RQ+LPC +DCP  +
Sbjct: 662 EAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWV 721

Query: 722 YSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNL 781
           Y+LM ECWNE PSRRPRFKDIH RLR+W  LS++ SS   SG + TTQT+SLS SPVSN+
Sbjct: 722 YALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNV 781

Query: 782 SNPRYPNYMFPSQGITPQGQ-----IAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHY 836
           SN R   Y+ P Q   P  Q     + G I P +P  Q ++P+NGY   P Y A+    Y
Sbjct: 782 SNAR---YVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFY 838

Query: 837 QPTGPPRVI-QHCPP---PKSRSPSSASGSTSTGHVTSLPSSGS 876
               P ++  Q  PP   PK  S  S SGSTSTG+VT+ PS+ S
Sbjct: 839 PVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTS 882


>gi|134152686 receptor tyrosine kinase-like orphan receptor 1
           isoform 2 [Homo sapiens]
          Length = 393

 Score =  821 bits (2121), Expect = 0.0
 Identities = 391/391 (100%), Positives = 391/391 (100%)

Query: 1   MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL 60
           MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL
Sbjct: 1   MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL 60

Query: 61  DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN 120
           DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN
Sbjct: 61  DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN 120

Query: 121 LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR 180
           LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR
Sbjct: 121 LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR 180

Query: 181 FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS 240
           FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS
Sbjct: 181 FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS 240

Query: 241 VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG 300
           VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG
Sbjct: 241 VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG 300

Query: 301 IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS 360
           IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS
Sbjct: 301 IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS 360

Query: 361 YCRNPGNQKEAPWCFTLDENFKSDLCDIPAC 391
           YCRNPGNQKEAPWCFTLDENFKSDLCDIPAC
Sbjct: 361 YCRNPGNQKEAPWCFTLDENFKSDLCDIPAC 391


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  302 bits (773), Expect = 1e-81
 Identities = 224/704 (31%), Positives = 332/704 (47%), Gaps = 96/704 (13%)

Query: 65  NNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTT 124
           +N+T   G    LHC  +G P PTI W +N   V     + S +  +  SRL+   L  T
Sbjct: 221 HNVT--FGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQ---LFIT 275

Query: 125 DTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGN 184
             G + C+ATN      ST            + P    + +  G+C  YRG  C      
Sbjct: 276 KPGLYTCIATNKHGEKFSTAKAAATISIAEWSKP----QKDNKGYCAQYRGEVC------ 325

Query: 185 RTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKP 244
                          N + A   ++  ++  +D   + A   L H A+      S V   
Sbjct: 326 ---------------NAVLAKDALVFLNTSYADP--EEAQELLVHTAWNELKVVSPV--- 365

Query: 245 RDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMA 304
              CR   E L   LC   +IF   +P ++    +P C +     + +   C +  + M 
Sbjct: 366 ---CRPAAEAL---LCN--HIFQECSPGVVPT-PIPICREYCL--AVKELFCAKEWLVME 414

Query: 305 DPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRN 364
           +   K H+        YR  + +  S  +C    S   H       R P L+       N
Sbjct: 415 E---KTHRGL------YRSEMHLL-SVPECSKLPSM--HWDPTACARLPHLD------YN 456

Query: 365 PGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKN-----KMEILYILVPSVAIPLAIA 419
             N K  P              DIP   S  S   +      M ++  ++ S AI + + 
Sbjct: 457 KENLKTFP-----PMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLT 511

Query: 420 LLFFFICVCRN---NQKSSSA-------PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELP 469
           +   + C  R    N+K  SA       P +     +    +   M     PK  + E P
Sbjct: 512 ITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYP 571

Query: 470 LSAVRFMEELGECAFGKIYKGHLYLPGM---DHAQLVAIKTLKDYNNPQQWTEFQQEASL 526
            + + ++ ++GE AFG++++     PG+   +   +VA+K LK+  +     +FQ+EA+L
Sbjct: 572 RNNIEYVRDIGEGAFGRVFQARA--PGLLPYEPFTMVAVKMLKEEASADMQADFQREAAL 629

Query: 527 MAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPH-------SDVGCSSDE 579
           MAE  +PNIV LLG     +P+C+LFEY+  GDL+EFL   SPH       SD+   +  
Sbjct: 630 MAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQV 689

Query: 580 DGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSRE 639
                  L   + L IA Q+AAGM YLS   FVH+DLA RN L+GE + VKI+D GLSR 
Sbjct: 690 SSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRN 749

Query: 640 IYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQ 699
           IYSADYY+      +PIRWMPPE+I Y +++++SD+W++GVVLWEIFS+GLQPYYG +++
Sbjct: 750 IYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHE 809

Query: 700 EVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIH 743
           EVI  VR   +L C E+CP  +Y+LM  CW+++P+ RP F  IH
Sbjct: 810 EVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIH 853



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 4/76 (5%)

Query: 60  LDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIR 119
           +  P  N+    G  A L C   GNP P++ W K D+P+    R  S  + +    LRI 
Sbjct: 123 ITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPL----RENSRIAVLESGSLRIH 178

Query: 120 NLDTTDTGYFQCVATN 135
           N+   D G ++CVA N
Sbjct: 179 NVQKEDAGQYRCVAKN 194



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 30/97 (30%), Positives = 41/97 (42%), Gaps = 3/97 (3%)

Query: 63  PMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLD 122
           P+  +   + + A   C V   P P I W +N   +     R S R    G  L I +++
Sbjct: 33  PLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIREN--GQLLTILSVE 90

Query: 123 TTDTGYFQCVATNG-KEVVSSTGVLFVKFGPPPTASP 158
            +D G + C A NG    V S G L VK  P  T  P
Sbjct: 91  DSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPP 127


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score =  254 bits (648), Expect = 3e-67
 Identities = 136/313 (43%), Positives = 187/313 (59%), Gaps = 14/313 (4%)

Query: 438 PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY--LP 495
           PV   P++    N ++      KP +  + +    +    ELGE AFGK++    Y   P
Sbjct: 509 PVIENPQYFGITNSQL------KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCP 562

Query: 496 GMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYI 555
             D   LVA+KTLKD ++  +  +F +EA L+  L H +IV   G   +  P+ M+FEY+
Sbjct: 563 EQDKI-LVAVKTLKDASDNAR-KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYM 620

Query: 556 NQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKD 615
             GDL++FL    P + +      +G   + L     LHIA QIAAGM YL+S  FVH+D
Sbjct: 621 KHGDLNKFLRAHGPDAVLMA----EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRD 676

Query: 616 LAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDI 675
           LA RN L+GE L VKI D G+SR++YS DYYRV   ++LPIRWMPPE+IMY KF+++SD+
Sbjct: 677 LATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDV 736

Query: 676 WSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSR 735
           WS GVVLWEIF++G QP+Y  SN EVIE + + ++L     CP  +Y LM  CW   P  
Sbjct: 737 WSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHM 796

Query: 736 RPRFKDIHVRLRS 748
           R   K IH  L++
Sbjct: 797 RKNIKGIHTLLQN 809



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 6/91 (6%)

Query: 66  NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTD 125
           N+T   G++  L C V+G+P P + W   +       + ++  S   GS LRI N+ + D
Sbjct: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDVGNL----VSKHMNETSHTQGS-LRITNISSDD 259

Query: 126 TG-YFQCVATNGKEVVSSTGVLFVKFGPPPT 155
           +G    CVA N       +  L V F P  T
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTIT 290



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 8/94 (8%)

Query: 81  VSGNPPPTIRWFKNDAPVVQEPRRLSFR-----STIYGSRLRIRNLDTTDTGYFQCVATN 135
           V GNP P ++WF N A ++ E + +  +      T Y   L++ N    + G +  +A N
Sbjct: 307 VKGNPKPALQWFYNGA-ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365

Query: 136 --GKEVVSSTGVLFVKFGPPPTASPGYSDEYEED 167
             GK+    +       G    A+P Y D   ED
Sbjct: 366 EYGKDEKQISAHFMGWPGIDDGANPNYPDVIYED 399


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
           a precursor [Homo sapiens]
          Length = 838

 Score =  254 bits (648), Expect = 3e-67
 Identities = 136/313 (43%), Positives = 187/313 (59%), Gaps = 14/313 (4%)

Query: 438 PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY--LP 495
           PV   P++    N ++      KP +  + +    +    ELGE AFGK++    Y   P
Sbjct: 525 PVIENPQYFGITNSQL------KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCP 578

Query: 496 GMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYI 555
             D   LVA+KTLKD ++  +  +F +EA L+  L H +IV   G   +  P+ M+FEY+
Sbjct: 579 EQDKI-LVAVKTLKDASDNAR-KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYM 636

Query: 556 NQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKD 615
             GDL++FL    P + +      +G   + L     LHIA QIAAGM YL+S  FVH+D
Sbjct: 637 KHGDLNKFLRAHGPDAVLMA----EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRD 692

Query: 616 LAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDI 675
           LA RN L+GE L VKI D G+SR++YS DYYRV   ++LPIRWMPPE+IMY KF+++SD+
Sbjct: 693 LATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDV 752

Query: 676 WSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSR 735
           WS GVVLWEIF++G QP+Y  SN EVIE + + ++L     CP  +Y LM  CW   P  
Sbjct: 753 WSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHM 812

Query: 736 RPRFKDIHVRLRS 748
           R   K IH  L++
Sbjct: 813 RKNIKGIHTLLQN 825



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 6/91 (6%)

Query: 66  NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTD 125
           N+T   G++  L C V+G+P P + W   +       + ++  S   GS LRI N+ + D
Sbjct: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDVGNL----VSKHMNETSHTQGS-LRITNISSDD 259

Query: 126 TG-YFQCVATNGKEVVSSTGVLFVKFGPPPT 155
           +G    CVA N       +  L V F P  T
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTIT 290



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 8/94 (8%)

Query: 81  VSGNPPPTIRWFKNDAPVVQEPRRLSFR-----STIYGSRLRIRNLDTTDTGYFQCVATN 135
           V GNP P ++WF N A ++ E + +  +      T Y   L++ N    + G +  +A N
Sbjct: 307 VKGNPKPALQWFYNGA-ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365

Query: 136 --GKEVVSSTGVLFVKFGPPPTASPGYSDEYEED 167
             GK+    +       G    A+P Y D   ED
Sbjct: 366 EYGKDEKQISAHFMGWPGIDDGANPNYPDVIYED 399


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score =  251 bits (641), Expect = 2e-66
 Identities = 128/273 (46%), Positives = 177/273 (64%), Gaps = 6/273 (2%)

Query: 478 ELGECAFGKIYKG--HLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNI 535
           ELGE AFGK++    H  LP  D   LVA+K LK+ +   +  +FQ+EA L+  L H +I
Sbjct: 509 ELGEGAFGKVFLAECHNLLPEQDK-MLVAVKALKEASESAR-QDFQREAELLTMLQHQHI 566

Query: 536 VCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHI 595
           V   G  T+ +P+ M+FEY+  GDL+ FL  RS   D    +  +      L  G  L +
Sbjct: 567 VRFFGVCTEGRPLLMVFEYMRHGDLNRFL--RSHGPDAKLLAGGEDVAPGPLGLGQLLAV 624

Query: 596 AIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLP 655
           A Q+AAGM YL+   FVH+DLA RN L+G+ L VKI D G+SR+IYS DYYRV  +++LP
Sbjct: 625 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 684

Query: 656 IRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSE 715
           IRWMPPE+I+Y KF+++SD+WSFGVVLWEIF++G QP+Y  SN E I+ + + + L    
Sbjct: 685 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 744

Query: 716 DCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS 748
            CPP +Y++M  CW   P +R   KD+H RL++
Sbjct: 745 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA 777


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score =  251 bits (641), Expect = 2e-66
 Identities = 128/273 (46%), Positives = 177/273 (64%), Gaps = 6/273 (2%)

Query: 478 ELGECAFGKIYKG--HLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNI 535
           ELGE AFGK++    H  LP  D   LVA+K LK+ +   +  +FQ+EA L+  L H +I
Sbjct: 515 ELGEGAFGKVFLAECHNLLPEQDK-MLVAVKALKEASESAR-QDFQREAELLTMLQHQHI 572

Query: 536 VCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHI 595
           V   G  T+ +P+ M+FEY+  GDL+ FL  RS   D    +  +      L  G  L +
Sbjct: 573 VRFFGVCTEGRPLLMVFEYMRHGDLNRFL--RSHGPDAKLLAGGEDVAPGPLGLGQLLAV 630

Query: 596 AIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLP 655
           A Q+AAGM YL+   FVH+DLA RN L+G+ L VKI D G+SR+IYS DYYRV  +++LP
Sbjct: 631 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 690

Query: 656 IRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSE 715
           IRWMPPE+I+Y KF+++SD+WSFGVVLWEIF++G QP+Y  SN E I+ + + + L    
Sbjct: 691 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 750

Query: 716 DCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS 748
            CPP +Y++M  CW   P +R   KD+H RL++
Sbjct: 751 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA 783


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score =  251 bits (641), Expect = 2e-66
 Identities = 128/273 (46%), Positives = 177/273 (64%), Gaps = 6/273 (2%)

Query: 478 ELGECAFGKIYKG--HLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNI 535
           ELGE AFGK++    H  LP  D   LVA+K LK+ +   +  +FQ+EA L+  L H +I
Sbjct: 479 ELGEGAFGKVFLAECHNLLPEQDK-MLVAVKALKEASESAR-QDFQREAELLTMLQHQHI 536

Query: 536 VCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHI 595
           V   G  T+ +P+ M+FEY+  GDL+ FL  RS   D    +  +      L  G  L +
Sbjct: 537 VRFFGVCTEGRPLLMVFEYMRHGDLNRFL--RSHGPDAKLLAGGEDVAPGPLGLGQLLAV 594

Query: 596 AIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLP 655
           A Q+AAGM YL+   FVH+DLA RN L+G+ L VKI D G+SR+IYS DYYRV  +++LP
Sbjct: 595 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 654

Query: 656 IRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSE 715
           IRWMPPE+I+Y KF+++SD+WSFGVVLWEIF++G QP+Y  SN E I+ + + + L    
Sbjct: 655 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 714

Query: 716 DCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS 748
            CPP +Y++M  CW   P +R   KD+H RL++
Sbjct: 715 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA 747


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score =  247 bits (630), Expect = 4e-65
 Identities = 130/307 (42%), Positives = 182/307 (59%), Gaps = 9/307 (2%)

Query: 438 PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-LPG 496
           PV   P++ R  +      N +KP +  + +    +    ELGE AFGK++    Y L  
Sbjct: 509 PVIENPQYFRQGH------NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSP 562

Query: 497 MDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYIN 556
                LVA+K LKD     +  +FQ+EA L+  L H +IV   G      P+ M+FEY+ 
Sbjct: 563 TKDKMLVAVKALKDPTLAAR-KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMK 621

Query: 557 QGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDL 616
            GDL++FL    P + +     +    K  L     LHIA QIA+GM YL+S  FVH+DL
Sbjct: 622 HGDLNKFLRAHGPDAMI-LVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDL 680

Query: 617 AARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIW 676
           A RN L+G  L VKI D G+SR++YS DYYRV   ++LPIRWMPPE+IMY KF+++SD+W
Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740

Query: 677 SFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRR 736
           SFGV+LWEIF++G QP++  SN EVIE + + ++L     CP  +Y +M  CW   P +R
Sbjct: 741 SFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQR 800

Query: 737 PRFKDIH 743
              K+I+
Sbjct: 801 LNIKEIY 807



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 1/88 (1%)

Query: 66  NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTD 125
           N+T   G  A + C  SG+P P + W       +   +     + ++   L + N+ + D
Sbjct: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277

Query: 126 TGY-FQCVATNGKEVVSSTGVLFVKFGP 152
            G+   C+A N   + +++  L V + P
Sbjct: 278 NGFTLTCIAENVVGMSNASVALTVYYPP 305



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 17/55 (30%), Positives = 24/55 (43%), Gaps = 3/55 (5%)

Query: 47  NISSELNKDSYLTLDEPMNNITTSLGQTAELHC---KVSGNPPPTIRWFKNDAPV 98
           N+    N    LT+  P   ++    +    HC    V GNPPPT+ W  N  P+
Sbjct: 288 NVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPL 342


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
           a precursor [Homo sapiens]
          Length = 839

 Score =  237 bits (605), Expect = 3e-62
 Identities = 130/321 (40%), Positives = 183/321 (57%), Gaps = 23/321 (7%)

Query: 438 PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-LPG 496
           PV   P++ R  +      N +KP +  + +    +    ELGE AFGK++    Y L  
Sbjct: 509 PVIENPQYFRQGH------NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSP 562

Query: 497 MDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYIN 556
                LVA+K LKD     +  +FQ+EA L+  L H +IV   G      P+ M+FEY+ 
Sbjct: 563 TKDKMLVAVKALKDPTLAAR-KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMK 621

Query: 557 QGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDL 616
            GDL++FL    P + +     +    K  L     LHIA QIA+GM YL+S  FVH+DL
Sbjct: 622 HGDLNKFLRAHGPDAMI-LVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDL 680

Query: 617 AARNILIGEQLHVKISDLGLSREIYSADYYRVQSKS--------------LLPIRWMPPE 662
           A RN L+G  L VKI D G+SR++YS DYYR+ + S              +LPIRWMPPE
Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPE 740

Query: 663 AIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMY 722
           +IMY KF+++SD+WSFGV+LWEIF++G QP++  SN EVIE + + ++L     CP  +Y
Sbjct: 741 SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVY 800

Query: 723 SLMTECWNEIPSRRPRFKDIH 743
            +M  CW   P +R   K+I+
Sbjct: 801 DVMLGCWQREPQQRLNIKEIY 821



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 1/88 (1%)

Query: 66  NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTD 125
           N+T   G  A + C  SG+P P + W       +   +     + ++   L + N+ + D
Sbjct: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277

Query: 126 TGY-FQCVATNGKEVVSSTGVLFVKFGP 152
            G+   C+A N   + +++  L V + P
Sbjct: 278 NGFTLTCIAENVVGMSNASVALTVYYPP 305



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 17/55 (30%), Positives = 24/55 (43%), Gaps = 3/55 (5%)

Query: 47  NISSELNKDSYLTLDEPMNNITTSLGQTAELHC---KVSGNPPPTIRWFKNDAPV 98
           N+    N    LT+  P   ++    +    HC    V GNPPPT+ W  N  P+
Sbjct: 288 NVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPL 342


>gi|62420886 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  211 bits (536), Expect = 3e-54
 Identities = 120/301 (39%), Positives = 173/301 (57%), Gaps = 27/301 (8%)

Query: 466 KELPLSAVRFMEELGECAFGKIY----KGHLYLPGMDHAQ--------LVAIKTLKDYNN 513
           +E P   + F E+LGE  FG+++    +G       D A         LVA+K L+   N
Sbjct: 556 EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN 615

Query: 514 PQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDV 573
                +F +E  +M+ L  PNI+ LL     + P+CM+ EY+  GDL++FL   S H   
Sbjct: 616 KNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFL---SRHEPP 672

Query: 574 GCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISD 633
             SS +  TV     + +   +A QIA+GM+YLSS  FVH+DLA RN L+G+   +KI+D
Sbjct: 673 NSSSSDVRTVS----YTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIAD 728

Query: 634 LGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSF-GLQP 692
            G+SR +YS DYYR+Q +++LPIRWM  E+I+ GKF++ SD+W+FGV LWE F+F   QP
Sbjct: 729 FGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQP 788

Query: 693 YYGFSNQEVIEMV-------RKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVR 745
           Y   S+++VIE          ++  LP    CP  +Y LM  CW      RP F++IH+ 
Sbjct: 789 YSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLL 848

Query: 746 L 746
           L
Sbjct: 849 L 849


>gi|62420884 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  211 bits (536), Expect = 3e-54
 Identities = 120/301 (39%), Positives = 173/301 (57%), Gaps = 27/301 (8%)

Query: 466 KELPLSAVRFMEELGECAFGKIY----KGHLYLPGMDHAQ--------LVAIKTLKDYNN 513
           +E P   + F E+LGE  FG+++    +G       D A         LVA+K L+   N
Sbjct: 556 EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN 615

Query: 514 PQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDV 573
                +F +E  +M+ L  PNI+ LL     + P+CM+ EY+  GDL++FL   S H   
Sbjct: 616 KNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFL---SRHEPP 672

Query: 574 GCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISD 633
             SS +  TV     + +   +A QIA+GM+YLSS  FVH+DLA RN L+G+   +KI+D
Sbjct: 673 NSSSSDVRTVS----YTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIAD 728

Query: 634 LGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSF-GLQP 692
            G+SR +YS DYYR+Q +++LPIRWM  E+I+ GKF++ SD+W+FGV LWE F+F   QP
Sbjct: 729 FGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQP 788

Query: 693 YYGFSNQEVIEMV-------RKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVR 745
           Y   S+++VIE          ++  LP    CP  +Y LM  CW      RP F++IH+ 
Sbjct: 789 YSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLL 848

Query: 746 L 746
           L
Sbjct: 849 L 849


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  210 bits (535), Expect = 4e-54
 Identities = 126/358 (35%), Positives = 188/358 (52%), Gaps = 25/358 (6%)

Query: 404  ILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQ-PKHVRGQNVEMSMLNAYKPK 462
            IL ++  ++   L +A     I   R +Q+  +  ++ Q P++   +    +++  Y P 
Sbjct: 1036 ILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPN 1095

Query: 463  ----------SKAKELPLSAVRFMEELGECAFGKIYKGHLY-LPGMDHAQLVAIKTLKDY 511
                      S  KE+P   +  +  LG  AFG++Y+G +  +P       VA+KTL + 
Sbjct: 1096 YCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEV 1155

Query: 512  NNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHS 571
             + Q   +F  EA ++++ +H NIV  +G   Q  P  +L E +  GDL  FL    P  
Sbjct: 1156 CSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRP 1215

Query: 572  DVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILI---GEQLH 628
                      +  SSL   D LH+A  IA G +YL  + F+H+D+AARN L+   G    
Sbjct: 1216 ----------SQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRV 1265

Query: 629  VKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSF 688
             KI D G++R+IY A YYR    ++LP++WMPPEA M G F+S +D WSFGV+LWEIFS 
Sbjct: 1266 AKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSL 1325

Query: 689  GLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL 746
            G  PY   SNQEV+E V     +   ++CP  +Y +MT+CW   P  RP F  I  R+
Sbjct: 1326 GYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI 1383


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  210 bits (534), Expect = 6e-54
 Identities = 109/277 (39%), Positives = 168/277 (60%), Gaps = 8/277 (2%)

Query: 467  ELPLSAVRFMEELGECAFGKIYKGHLY-LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEAS 525
            E+P   +  + ELG+ +FG +Y+G    L   + +  VA+KT+ +  +P++  EF +EAS
Sbjct: 973  EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEAS 1032

Query: 526  LMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKS 585
            +M      ++V LLG V+Q QP  ++ E + +GDL   L    P ++     +  G  + 
Sbjct: 1033 VMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE-----NNPGLPQP 1087

Query: 586  SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADY 645
            +L  G+ + +A +IA GM YL+++ FVH+DLAARN ++ +   VKI D G++R++Y  DY
Sbjct: 1088 AL--GEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDY 1145

Query: 646  YRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMV 705
            YR   K LLP+RWM PE++  G F++ SD+WSFGVVLWEI +   QPY G SN++V++ V
Sbjct: 1146 YRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV 1205

Query: 706  RKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDI 742
                +L   E CP ++  LM+ CW   P  RP F  I
Sbjct: 1206 MDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHI 1242


>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
          Length = 984

 Score =  208 bits (530), Expect = 2e-53
 Identities = 117/281 (41%), Positives = 165/281 (58%), Gaps = 20/281 (7%)

Query: 465 AKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEA 524
           AKE+ +S V+  E +G   FG++YKG L LPG      VAIKTLK   + +Q  +F  EA
Sbjct: 611 AKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIY-VAIKTLKAGYSEKQRRDFLSEA 669

Query: 525 SLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVK 584
           S+M +  HPNI+ L G VT+ +PV ++ E++  G L  FL            +D   TV 
Sbjct: 670 SIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQ----------NDGQFTVI 719

Query: 585 SSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSAD 644
                   + +   IAAGM+YL+   +VH+DLAARNIL+   L  K+SD GLSR +    
Sbjct: 720 Q------LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDT 773

Query: 645 YYRVQSKSL---LPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEV 701
                + SL   +P+RW  PEAI Y KF+S SD+WS+G+V+WE+ SFG +PY+  SNQ+V
Sbjct: 774 SDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDV 833

Query: 702 IEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDI 742
           I  + +   LP   DCP  ++ LM +CW +  + RPRF +I
Sbjct: 834 INAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI 874


>gi|38327632 discoidin domain receptor family, member 1 isoform b
           [Homo sapiens]
          Length = 876

 Score =  208 bits (529), Expect = 2e-53
 Identities = 113/299 (37%), Positives = 170/299 (56%), Gaps = 22/299 (7%)

Query: 467 ELPLSAVRFMEELGECAFGKIYKGHLYLP----GMD--------HAQLVAIKTLKDYNNP 514
           + P S +RF E+LGE  FG+++   +  P     +D        H  LVA+K L+     
Sbjct: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626

Query: 515 QQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVG 574
               +F +E  +M+ L  PNI+ LLG   Q+ P+CM+ +Y+  GDL++FL          
Sbjct: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686

Query: 575 CSSDEDGTVKS--SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKIS 632
             +  DG      ++ +   LH+A QIA+GM YL++  FVH+DLA RN L+GE   +KI+
Sbjct: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746

Query: 633 DLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSF-GLQ 691
           D G+SR +Y+ DYYRVQ +++LPIRWM  E I+ GKF++ SD+W+FGV LWE+      Q
Sbjct: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ 806

Query: 692 PYYGFSNQEVIEMV------RKRQL-LPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIH 743
           P+   ++++VIE        + RQ+ L     CP  +Y LM  CW+    +RP F  +H
Sbjct: 807 PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865


>gi|83977450 discoidin domain receptor family, member 1 isoform a
           [Homo sapiens]
          Length = 913

 Score =  208 bits (529), Expect = 2e-53
 Identities = 113/299 (37%), Positives = 170/299 (56%), Gaps = 22/299 (7%)

Query: 467 ELPLSAVRFMEELGECAFGKIYKGHLYLP----GMD--------HAQLVAIKTLKDYNNP 514
           + P S +RF E+LGE  FG+++   +  P     +D        H  LVA+K L+     
Sbjct: 604 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 663

Query: 515 QQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVG 574
               +F +E  +M+ L  PNI+ LLG   Q+ P+CM+ +Y+  GDL++FL          
Sbjct: 664 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 723

Query: 575 CSSDEDGTVKS--SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKIS 632
             +  DG      ++ +   LH+A QIA+GM YL++  FVH+DLA RN L+GE   +KI+
Sbjct: 724 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 783

Query: 633 DLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSF-GLQ 691
           D G+SR +Y+ DYYRVQ +++LPIRWM  E I+ GKF++ SD+W+FGV LWE+      Q
Sbjct: 784 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQ 843

Query: 692 PYYGFSNQEVIEMV------RKRQL-LPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIH 743
           P+   ++++VIE        + RQ+ L     CP  +Y LM  CW+    +RP F  +H
Sbjct: 844 PFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 902


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  206 bits (524), Expect = 8e-53
 Identities = 110/277 (39%), Positives = 162/277 (58%), Gaps = 8/277 (2%)

Query: 467  ELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQL-VAIKTLKDYNNPQQWTEFQQEAS 525
            E+    +    ELG+ +FG +Y+G       D  +  VAIKT+ +  + ++  EF  EAS
Sbjct: 993  EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1052

Query: 526  LMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKS 585
            +M E +  ++V LLG V+Q QP  ++ E + +GDL  +L    P         E+  V +
Sbjct: 1053 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEM-------ENNPVLA 1105

Query: 586  SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADY 645
                   + +A +IA GM YL+++ FVH+DLAARN ++ E   VKI D G++R+IY  DY
Sbjct: 1106 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 1165

Query: 646  YRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMV 705
            YR   K LLP+RWM PE++  G F++ SD+WSFGVVLWEI +   QPY G SN++V+  V
Sbjct: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225

Query: 706  RKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDI 742
             +  LL   ++CP  ++ LM  CW   P  RP F +I
Sbjct: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262


>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
          Length = 976

 Score =  204 bits (519), Expect = 3e-52
 Identities = 109/268 (40%), Positives = 156/268 (58%), Gaps = 17/268 (6%)

Query: 479 LGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCL 538
           +GE  FG++Y+G L LP  D  + VAIKTLKD +   QW  F +EA++M +  HP+I+ L
Sbjct: 630 IGEGEFGEVYRGTLRLPSQD-CKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHL 688

Query: 539 LGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQ 598
            G VT+ +P+ ++ E++  G L  FL  R                +  L  G  + +   
Sbjct: 689 EGVVTKRKPIMIITEFMENGALDAFLRER----------------EDQLVPGQLVAMLQG 732

Query: 599 IAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRW 658
           IA+GM YLS+H +VH+DLAARNIL+ + L  K+SD GL+R +   D         +PIRW
Sbjct: 733 IASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRW 792

Query: 659 MPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCP 718
             PEAI +  F++ SD+WSFG+V+WE+ SFG +PY   SNQEV++ +     LP   DCP
Sbjct: 793 TAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCP 852

Query: 719 PRMYSLMTECWNEIPSRRPRFKDIHVRL 746
             +Y LM  CW    +RRP F+ +   L
Sbjct: 853 APLYELMKNCWAYDRARRPHFQKLQAHL 880


>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
          Length = 1074

 Score =  204 bits (518), Expect = 4e-52
 Identities = 130/381 (34%), Positives = 191/381 (50%), Gaps = 34/381 (8%)

Query: 461 PKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEF 520
           P ++  E+    +     +GE  FG +++G +Y+   + A  VAIKT K+  +     +F
Sbjct: 432 PSTRDYEIQRERIELGRCIGEGQFGDVHQG-IYMSPENPALAVAIKTCKNCTSDSVREKF 490

Query: 521 QQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDED 580
            QEA  M +  HP+IV L+G +T E PV ++ E    G+L  FL +R             
Sbjct: 491 LQEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVR------------- 536

Query: 581 GTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREI 640
              K SLD    +  A Q++  + YL S  FVH+D+AARN+L+     VK+ D GLSR +
Sbjct: 537 ---KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM 593

Query: 641 YSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQE 700
             + YY+  SK  LPI+WM PE+I + +F+S SD+W FGV +WEI   G++P+ G  N +
Sbjct: 594 EDSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND 652

Query: 701 VIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS---WEGLSSHTS 757
           VI  +   + LP   +CPP +YSLMT+CW   PSRRPRF ++  +L +    E       
Sbjct: 653 VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEER 712

Query: 758 STTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFP--SQGITPQGQIAGFIGPPIPQNQR 815
               S   AT    S  +        P  P Y  P  S+G  P  Q        + Q   
Sbjct: 713 MRMESRRQATVSWDSGGSDEAP--PKPSRPGYPSPRSSEGFYPSPQ-------HMVQTNH 763

Query: 816 FIPINGYPIPPGYAAFPAAHY 836
           +  ++GYP   G  A   + Y
Sbjct: 764 Y-QVSGYPGSHGITAMAGSIY 783


>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
          Length = 1052

 Score =  204 bits (518), Expect = 4e-52
 Identities = 130/381 (34%), Positives = 191/381 (50%), Gaps = 34/381 (8%)

Query: 461 PKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEF 520
           P ++  E+    +     +GE  FG +++G +Y+   + A  VAIKT K+  +     +F
Sbjct: 410 PSTRDYEIQRERIELGRCIGEGQFGDVHQG-IYMSPENPALAVAIKTCKNCTSDSVREKF 468

Query: 521 QQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDED 580
            QEA  M +  HP+IV L+G +T E PV ++ E    G+L  FL +R             
Sbjct: 469 LQEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVR------------- 514

Query: 581 GTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREI 640
              K SLD    +  A Q++  + YL S  FVH+D+AARN+L+     VK+ D GLSR +
Sbjct: 515 ---KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM 571

Query: 641 YSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQE 700
             + YY+  SK  LPI+WM PE+I + +F+S SD+W FGV +WEI   G++P+ G  N +
Sbjct: 572 EDSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND 630

Query: 701 VIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS---WEGLSSHTS 757
           VI  +   + LP   +CPP +YSLMT+CW   PSRRPRF ++  +L +    E       
Sbjct: 631 VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEER 690

Query: 758 STTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFP--SQGITPQGQIAGFIGPPIPQNQR 815
               S   AT    S  +        P  P Y  P  S+G  P  Q        + Q   
Sbjct: 691 MRMESRRQATVSWDSGGSDEAP--PKPSRPGYPSPRSSEGFYPSPQ-------HMVQTNH 741

Query: 816 FIPINGYPIPPGYAAFPAAHY 836
           +  ++GYP   G  A   + Y
Sbjct: 742 Y-QVSGYPGSHGITAMAGSIY 761


>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
          Length = 987

 Score =  204 bits (518), Expect = 4e-52
 Identities = 126/357 (35%), Positives = 181/357 (50%), Gaps = 39/357 (10%)

Query: 403 EILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQPKHVR-----GQNVEMSMLN 457
           E L ++  +  + + + L+   + V    ++S+    +   KH +     G  V +    
Sbjct: 536 EQLALIAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFT 595

Query: 458 AYKPKSK----AKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNN 513
              P       AKE+ +S V+  E +G   FG++ +G L  PG   +  VAIKTLK    
Sbjct: 596 YEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKES-CVAIKTLKGGYT 654

Query: 514 PQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDV 573
            +Q  EF  EAS+M +  HPNI+ L G VT   PV +L E++  G L  FL         
Sbjct: 655 ERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFL--------- 705

Query: 574 GCSSDEDGTVKSSLDHGDFLHIAIQ-----IAAGMEYLSSHFFVHKDLAARNILIGEQLH 628
                        L+ G F  I +      IA+GM YL+   +VH+DLAARNIL+   L 
Sbjct: 706 ------------RLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLV 753

Query: 629 VKISDLGLSR---EIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEI 685
            K+SD GLSR   E  S   Y       +PIRW  PEAI + KF+S SD WS+G+V+WE+
Sbjct: 754 CKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEV 813

Query: 686 FSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDI 742
            SFG +PY+  SNQ+VI  + +   LP   DCP  ++ LM +CW +  + RPRF  +
Sbjct: 814 MSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQV 870


>gi|83977452 discoidin domain receptor family, member 1 isoform c
           [Homo sapiens]
          Length = 919

 Score =  202 bits (515), Expect = 9e-52
 Identities = 114/305 (37%), Positives = 173/305 (56%), Gaps = 28/305 (9%)

Query: 467 ELPLSAVRFMEELGECAFGKIYKGHLYLP----GMD--------HAQLVAIKTLK-DYNN 513
           + P S +RF E+LGE  FG+++   +  P     +D        H  LVA+K L+ D   
Sbjct: 604 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 663

Query: 514 PQQWT-----EFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRS 568
              ++     +F +E  +M+ L  PNI+ LLG   Q+ P+CM+ +Y+  GDL++FL    
Sbjct: 664 NASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQ 723

Query: 569 PHSDVGCSSDEDGTVKS--SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQ 626
                   +  DG      ++ +   LH+A QIA+GM YL++  FVH+DLA RN L+GE 
Sbjct: 724 LEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN 783

Query: 627 LHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIF 686
             +KI+D G+SR +Y+ DYYRVQ +++LPIRWM  E I+ GKF++ SD+W+FGV LWE+ 
Sbjct: 784 FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 843

Query: 687 SF-GLQPYYGFSNQEVIEMV------RKRQL-LPCSEDCPPRMYSLMTECWNEIPSRRPR 738
                QP+   ++++VIE        + RQ+ L     CP  +Y LM  CW+    +RP 
Sbjct: 844 MLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPP 903

Query: 739 FKDIH 743
           F  +H
Sbjct: 904 FSQLH 908


>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
           [Homo sapiens]
          Length = 864

 Score =  202 bits (515), Expect = 9e-52
 Identities = 114/285 (40%), Positives = 159/285 (55%), Gaps = 14/285 (4%)

Query: 467 ELPLSAVRFMEELGECAFGKIYKGHLY-LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEAS 525
           E+  + V  +  LG  AFG++Y+G +  LPG      VAIKTL +  +PQ   +F  EA 
Sbjct: 504 EVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEAL 563

Query: 526 LMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKS 585
           ++++  H NIV  +G   +  P  +L E ++ GD+  FL    PH              S
Sbjct: 564 IISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQ----------PS 613

Query: 586 SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILI---GEQLHVKISDLGLSREIYS 642
            L   D L +A  IA G  YL  + F+H+D+AARN L+   G     KI D G++R+IY 
Sbjct: 614 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 673

Query: 643 ADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVI 702
           A YYR   ++LLP++WMPPEA + G F+S +D WSFGV+LWEIFS G  PY G +NQEV+
Sbjct: 674 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 733

Query: 703 EMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLR 747
           + V     +     CP  +Y +MT+CW   P  RP F  I  RL+
Sbjct: 734 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778


>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
           [Homo sapiens]
          Length = 803

 Score =  202 bits (515), Expect = 9e-52
 Identities = 114/285 (40%), Positives = 159/285 (55%), Gaps = 14/285 (4%)

Query: 467 ELPLSAVRFMEELGECAFGKIYKGHLY-LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEAS 525
           E+  + V  +  LG  AFG++Y+G +  LPG      VAIKTL +  +PQ   +F  EA 
Sbjct: 443 EVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEAL 502

Query: 526 LMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKS 585
           ++++  H NIV  +G   +  P  +L E ++ GD+  FL    PH              S
Sbjct: 503 IISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQ----------PS 552

Query: 586 SLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILI---GEQLHVKISDLGLSREIYS 642
            L   D L +A  IA G  YL  + F+H+D+AARN L+   G     KI D G++R+IY 
Sbjct: 553 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 612

Query: 643 ADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVI 702
           A YYR   ++LLP++WMPPEA + G F+S +D WSFGV+LWEIFS G  PY G +NQEV+
Sbjct: 613 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 672

Query: 703 EMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLR 747
           + V     +     CP  +Y +MT+CW   P  RP F  I  RL+
Sbjct: 673 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 717


>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
           sapiens]
          Length = 986

 Score =  201 bits (512), Expect = 2e-51
 Identities = 112/281 (39%), Positives = 160/281 (56%), Gaps = 20/281 (7%)

Query: 465 AKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEA 524
           AKE+ +S V+  + +G   FG++  GHL LPG      VAIKTLK     +Q  +F  EA
Sbjct: 613 AKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREI-FVAIKTLKSGYTEKQRRDFLSEA 671

Query: 525 SLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVK 584
           S+M +  HPN++ L G VT+  PV ++ E++  G L  FL            +D   TV 
Sbjct: 672 SIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQ----------NDGQFTVI 721

Query: 585 SSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIY--- 641
                   + +   IAAGM+YL+   +VH+DLAARNIL+   L  K+SD GLSR +    
Sbjct: 722 Q------LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDT 775

Query: 642 SADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEV 701
           S   Y       +PIRW  PEAI Y KF+S SD+WS+G+V+WE+ S+G +PY+  +NQ+V
Sbjct: 776 SDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDV 835

Query: 702 IEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDI 742
           I  + +   LP   DCP  ++ LM +CW +  + RP+F  I
Sbjct: 836 INAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQI 876


>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
           sapiens]
          Length = 987

 Score =  201 bits (512), Expect = 2e-51
 Identities = 112/281 (39%), Positives = 160/281 (56%), Gaps = 20/281 (7%)

Query: 465 AKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEA 524
           AKE+ +S V+  + +G   FG++  GHL LPG      VAIKTLK     +Q  +F  EA
Sbjct: 614 AKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREI-FVAIKTLKSGYTEKQRRDFLSEA 672

Query: 525 SLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVK 584
           S+M +  HPN++ L G VT+  PV ++ E++  G L  FL            +D   TV 
Sbjct: 673 SIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQ----------NDGQFTVI 722

Query: 585 SSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIY--- 641
                   + +   IAAGM+YL+   +VH+DLAARNIL+   L  K+SD GLSR +    
Sbjct: 723 Q------LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDT 776

Query: 642 SADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEV 701
           S   Y       +PIRW  PEAI Y KF+S SD+WS+G+V+WE+ S+G +PY+  +NQ+V
Sbjct: 777 SDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDV 836

Query: 702 IEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDI 742
           I  + +   LP   DCP  ++ LM +CW +  + RP+F  I
Sbjct: 837 INAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQI 877


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  201 bits (510), Expect = 3e-51
 Identities = 121/354 (34%), Positives = 185/354 (52%), Gaps = 17/354 (4%)

Query: 433 KSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHL 492
           KSSS+ V+       G  +   +++   P     E P   +   + LGE  FG++ +   
Sbjct: 387 KSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEA 446

Query: 493 YLPGMD-----HAQLVAIKTLKDYNNPQQWTEFQQEASLMAEL-HHPNIVCLLGAVTQEQ 546
           +  GMD      A  VA+K LKD  + +   +   E  +M  +  H NI+ LLG  TQE 
Sbjct: 447 F--GMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG 504

Query: 547 PVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYL 606
           P+ ++ E   +G+L EFL  R P      S D   + +  L     +  A Q+A GM+YL
Sbjct: 505 PLYVIVECAAKGNLREFLRARRPPGP-DLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYL 563

Query: 607 SSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMY 666
            S   +H+DLAARN+L+ E   +KI+D GL+R ++  DYY+  S   LP++WM PEA+  
Sbjct: 564 ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD 623

Query: 667 GKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMT 726
             ++  SD+WSFG++LWEIF+ G  PY G   +E+  ++R+   +     CPP +Y LM 
Sbjct: 624 RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMR 683

Query: 727 ECWNEIPSRRPRFKDIHVRL--------RSWEGLSSHTSSTTPSGGNATTQTTS 772
           ECW+  PS+RP FK +   L          +  L       +PSGG+A++  +S
Sbjct: 684 ECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSS 737



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 20/64 (31%), Positives = 29/64 (45%)

Query: 72  GQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQC 131
           G T +  C  +GNP PTIRW K+      E R    R       L + ++  +D G + C
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224

Query: 132 VATN 135
           +  N
Sbjct: 225 LVEN 228



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 12/81 (14%)

Query: 66  NITTSLGQTAELHCKVSGNPPPTIRWFK-----------NDAPVVQEPRRLSFRSTIYGS 114
           N T  +G   EL CKV  +  P I+W K           +  P VQ  +     S+    
Sbjct: 258 NTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEV-E 316

Query: 115 RLRIRNLDTTDTGYFQCVATN 135
            L +RN+   D G + C+A N
Sbjct: 317 VLYLRNVSAEDAGEYTCLAGN 337


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  201 bits (510), Expect = 3e-51
 Identities = 121/354 (34%), Positives = 185/354 (52%), Gaps = 17/354 (4%)

Query: 433 KSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHL 492
           KSSS+ V+       G  +   +++   P     E P   +   + LGE  FG++ +   
Sbjct: 427 KSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEA 486

Query: 493 YLPGMD-----HAQLVAIKTLKDYNNPQQWTEFQQEASLMAEL-HHPNIVCLLGAVTQEQ 546
           +  GMD      A  VA+K LKD  + +   +   E  +M  +  H NI+ LLG  TQE 
Sbjct: 487 F--GMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEG 544

Query: 547 PVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYL 606
           P+ ++ E   +G+L EFL  R P      S D   + +  L     +  A Q+A GM+YL
Sbjct: 545 PLYVIVECAAKGNLREFLRARRPPGP-DLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYL 603

Query: 607 SSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMY 666
            S   +H+DLAARN+L+ E   +KI+D GL+R ++  DYY+  S   LP++WM PEA+  
Sbjct: 604 ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD 663

Query: 667 GKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMT 726
             ++  SD+WSFG++LWEIF+ G  PY G   +E+  ++R+   +     CPP +Y LM 
Sbjct: 664 RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMR 723

Query: 727 ECWNEIPSRRPRFKDIHVRL--------RSWEGLSSHTSSTTPSGGNATTQTTS 772
           ECW+  PS+RP FK +   L          +  L       +PSGG+A++  +S
Sbjct: 724 ECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSS 777



 Score = 38.5 bits (88), Expect = 0.030
 Identities = 20/64 (31%), Positives = 29/64 (45%)

Query: 72  GQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQC 131
           G T +  C  +GNP PTIRW K+      E R    R       L + ++  +D G + C
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224

Query: 132 VATN 135
           +  N
Sbjct: 225 LVEN 228



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 12/81 (14%)

Query: 66  NITTSLGQTAELHCKVSGNPPPTIRWFK-----------NDAPVVQEPRRLSFRSTIYGS 114
           N T  +G   EL CKV  +  P I+W K           +  P VQ  +     S+    
Sbjct: 258 NTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEV-E 316

Query: 115 RLRIRNLDTTDTGYFQCVATN 135
            L +RN+   D G + C+A N
Sbjct: 317 VLYLRNVSAEDAGEYTCLAGN 337


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,535,750
Number of Sequences: 37866
Number of extensions: 2159636
Number of successful extensions: 11453
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 724
Number of HSP's successfully gapped in prelim test: 477
Number of HSP's that attempted gapping in prelim test: 7088
Number of HSP's gapped (non-prelim): 3180
length of query: 937
length of database: 18,247,518
effective HSP length: 112
effective length of query: 825
effective length of database: 14,006,526
effective search space: 11555383950
effective search space used: 11555383950
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.