Search of human proteins with 134133265

Search of human proteins with 134133265

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo
sapiens]
         (725 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]  1467   0.0  
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]  1467   0.0  
gi|24797153 faciogenital dysplasia protein [Homo sapiens]             630   e-180
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]   506   e-143
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]   469   e-132
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]   210   3e-54
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]   171   3e-42
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   126   8e-29
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   124   3e-28
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   112   9e-25
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   101   2e-21
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    99   1e-20
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    99   1e-20
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]           98   2e-20
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]           98   2e-20
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]           91   3e-18
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]            91   3e-18
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    91   5e-18
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...    87   7e-17
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...    87   7e-17
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    85   2e-16
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi...    85   2e-16
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    85   3e-16
gi|166197690 neuronal guanine nucleotide exchange factor isoform...    84   5e-16
gi|166197688 neuronal guanine nucleotide exchange factor isoform...    84   5e-16
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi...    84   5e-16
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]             84   6e-16
gi|23308553 spermatogenesis associated 13 [Homo sapiens]               82   2e-15
gi|71274148 pleckstrin homology domain containing, family G (wit...    81   4e-15
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    81   4e-15

>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 1467 bits (3799), Expect = 0.0
 Identities = 725/725 (100%), Positives = 725/725 (100%)

Query: 1   MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG 60
           MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG
Sbjct: 1   MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG 60

Query: 61  PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV 120
           PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV
Sbjct: 61  PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV 120

Query: 121 TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD 180
           TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD
Sbjct: 121 TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD 180

Query: 181 QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL 240
           QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL
Sbjct: 181 QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL 240

Query: 241 APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV 300
           APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV
Sbjct: 241 APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV 300

Query: 301 PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG 360
           PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG
Sbjct: 301 PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG 360

Query: 361 EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD 420
           EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD
Sbjct: 361 EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD 420

Query: 421 ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA 480
           ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA
Sbjct: 421 ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA 480

Query: 481 FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS 540
           FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS
Sbjct: 481 FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS 540

Query: 541 CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA 600
           CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA
Sbjct: 541 CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA 600

Query: 601 DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP 660
           DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP
Sbjct: 601 DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP 660

Query: 661 DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM 720
           DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM
Sbjct: 661 DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM 720

Query: 721 GAAAP 725
           GAAAP
Sbjct: 721 GAAAP 725


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 1467 bits (3799), Expect = 0.0
 Identities = 725/725 (100%), Positives = 725/725 (100%)

Query: 1   MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG 60
           MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG
Sbjct: 1   MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG 60

Query: 61  PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV 120
           PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV
Sbjct: 61  PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV 120

Query: 121 TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD 180
           TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD
Sbjct: 121 TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD 180

Query: 181 QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL 240
           QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL
Sbjct: 181 QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL 240

Query: 241 APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV 300
           APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV
Sbjct: 241 APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV 300

Query: 301 PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG 360
           PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG
Sbjct: 301 PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG 360

Query: 361 EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD 420
           EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD
Sbjct: 361 EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD 420

Query: 421 ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA 480
           ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA
Sbjct: 421 ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA 480

Query: 481 FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS 540
           FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS
Sbjct: 481 FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS 540

Query: 541 CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA 600
           CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA
Sbjct: 541 CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA 600

Query: 601 DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP 660
           DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP
Sbjct: 601 DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP 660

Query: 661 DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM 720
           DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM
Sbjct: 661 DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM 720

Query: 721 GAAAP 725
           GAAAP
Sbjct: 721 GAAAP 725


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score =  630 bits (1625), Expect = e-180
 Identities = 353/740 (47%), Positives = 458/740 (61%), Gaps = 81/740 (10%)

Query: 11  PGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLK 70
           PGP      P   P  +S   +  LP G  + C     L     G  D    GE     K
Sbjct: 232 PGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRC-----LFLLAPGPRD----GE-----K 277

Query: 71  IPNRDSGIDSPSSSVAGEN--FPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQEE 125
           +PNRDSGIDS SS    E   F  ++G  +    P P  L +      D   P     +E
Sbjct: 278 VPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPG---SQE 334

Query: 126 ADSDVGEEPDSENTPQKADKDAGL--------AQHSGPQKLLHIAQELLHTEETYVKRLH 177
            DSD+ EE D E   +K D++  +         + +  QK+ HIA ELL TE+ YV RLH
Sbjct: 335 VDSDLEEEDDEEEEEEK-DREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLH 393

Query: 178 LLDQVFCTRLTD-----AGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPR 232
           LLDQVFC RL +     +  P +V+ GIFSNI SI+ FH QFLLPEL+ R+ EEWD  PR
Sbjct: 394 LLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRM-EEWDRYPR 452

Query: 233 LGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHH 292
           +GDILQKLAPFLKMYGEYVKNFDRAV LV+TWT+RS  FK ++H +QK+E CGNLTLQHH
Sbjct: 453 IGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHH 512

Query: 293 MLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLL 352
           MLEPVQR+PRYELLLKDYL +LP  +PD KDA++SLELI+TAA HSNAAIRK+E+MHKLL
Sbjct: 513 MLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLL 572

Query: 353 EVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQK 412
           +VYE LGGEEDIV+P  ELIKEG I KLSAKNGT QDR+L LFN  +LYCVP+LRL+GQK
Sbjct: 573 KVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQK 632

Query: 413 FSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHK 472
           FSVR ++D+ G+++++    N   TF+++G++RSLELQ RTEEEKK+W+Q I +T+ KH+
Sbjct: 633 FSVRARIDVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHE 692

Query: 473 QNSETFKAFGGAFSQDED-PSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRR 531
           Q  ETFK       +DED P  SP++ +   +P  P+                      R
Sbjct: 693 QTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPT-PI----------------------R 729

Query: 532 DKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKA----ENSRQSRVCRDCFLTQ 587
           +KE   C  C E FNSITKRRHHCK CG V+CGKCSEF+A    +N+R +RVC DC++  
Sbjct: 730 EKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVAL 789

Query: 588 PVAPEST---------------EKTPTADPQPSLLCGPLR-LSESGETWSEVWAAIPMSD 631
              P S+               EK  +   + S++C  L  + + G+ W + W  +P ++
Sbjct: 790 HGVPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENE 849

Query: 632 PQVLHLQGGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQ 691
           P VL++ G  QD +  R++PL   ++  P+  ER D  HV+K+  +  SWY S  + ELQ
Sbjct: 850 PLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQ 909

Query: 692 QQWLETLSTAAHGDTAQDSP 711
           ++W+  L  A  GDT    P
Sbjct: 910 RRWMAVLGRAGRGDTFCPGP 929


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score =  506 bits (1303), Expect = e-143
 Identities = 278/608 (45%), Positives = 379/608 (62%), Gaps = 49/608 (8%)

Query: 120 VTPQEEADSDVGEEPDSENTPQKADKDAGLAQH-----SGPQKLLHIAQELLHTEETYVK 174
           V P EE  ++   +       +   +   L QH     +  QKL  IA ELL TE  YV 
Sbjct: 164 VLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVN 223

Query: 175 RLHLLDQVFCTRLTD----AGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTN 230
           RL LLDQVF  +L +       P E++  IFSNISSI+ FH +FLLPEL+ R+ +EW+T 
Sbjct: 224 RLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRM-QEWETT 282

Query: 231 PRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQ 290
           PR+GDILQKLAPFLKMYGEYVK FD A+ LV   T+R P FK VV  IQKQ++CG+LTLQ
Sbjct: 283 PRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQ 342

Query: 291 HHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHK 350
           HHMLEPVQR+PRYE+LLKDYL++LP D+ D  DA++SLE+ISTAA+HSN+AIRK+E + K
Sbjct: 343 HHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKK 402

Query: 351 LLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMG 410
           LLE+YE LG EEDIVNP+NELIKEGQI KL+A+N + Q+R+LFLFN+M+LYCVPK  L+G
Sbjct: 403 LLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVG 462

Query: 411 QKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEK 470
            KF+VR ++ I G+++ +       HTF ++G++R+LELQ  + ++K+EWI+ +Q TI+ 
Sbjct: 463 SKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDA 522

Query: 471 HKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTR 530
             Q  ETF+    A ++D D                  + +E S+   G    K + +  
Sbjct: 523 FHQRHETFR---NAIAKDND------------------IHSEVSTAELG----KRAPRWI 557

Query: 531 RDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKA----ENSRQSRVCRDCFLT 586
           RD E   C  C E FN++T+RRHHC+ CG V+C KCS++KA    +  + S+VC+DC+  
Sbjct: 558 RDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQI 617

Query: 587 QPVAPESTEKTPTADPQ--------PSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQ 638
                +S EK      +         S++C  L+  E  + W + W  IP  DP VL++ 
Sbjct: 618 ISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMY 677

Query: 639 GGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETL 698
           G  QD R   TIPL      V +     D  H +KL  +K     +A S EL+Q+WL+ +
Sbjct: 678 GAPQDVRAQATIPL--LGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVI 735

Query: 699 STAAHGDT 706
             A  G+T
Sbjct: 736 LLAVTGET 743


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score =  469 bits (1208), Expect = e-132
 Identities = 248/566 (43%), Positives = 368/566 (65%), Gaps = 51/566 (9%)

Query: 161 IAQELLHTEETYVKRLHLLDQVFCTRL-----TDAGIPPEVIMGIFSNISSIHRFHGQFL 215
           I QELL TE+ YV RLHLLDQVF   L     +    P +V+  IFSNISSI++FH QF 
Sbjct: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFF 165

Query: 216 LPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVV 275
           LPEL+ R+ ++W  NPR+GD++QKLAPFLKMY EYVKNF+RA  L++TWT +SPLF++V+
Sbjct: 166 LPELQRRL-DDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVL 224

Query: 276 HSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAA 335
             IQ  E  G+LTLQHHMLEPVQR+PRYELLLK+Y+++LP  APD+ DA+++L++I +AA
Sbjct: 225 TRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAA 284

Query: 336 NHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLF 395
            HSNAAI ++E++  L EVY++LG E+DIV+P+N L++EG + K+S +   P +R+LFLF
Sbjct: 285 QHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLF 344

Query: 396 NSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEE 455
           N+M+LYCVP++  +G +F VR ++D++G++V++++     H+F+++G++R+LELQ R++E
Sbjct: 345 NNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQE 404

Query: 456 EKKEWIQIIQATIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSS 515
           E   W+Q  QA I++ ++ +ETFKA                    +  P   +   E  S
Sbjct: 405 EMISWMQAFQAAIDQIEKRNETFKA-------------------AAQGPEGDIQEQELQS 445

Query: 516 GAAGLEPRKLSSKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAE--- 572
              GL     + +  RDK    C  C E FN++T+RRHHC+ CG V+C +CS+++AE   
Sbjct: 446 EELGLR----APQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKY 501

Query: 573 -NSRQSRVCRDC--FLTQPVAPES--------TEKTPTADPQPSLLCGPLRL--SESGET 619
            ++R +RVC  C  FLT  V PE+         EK  +A P  SL+C  L+L   + G++
Sbjct: 502 DDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKS 561

Query: 620 WSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSV-PDPEERLDSGHVWKLQWAK 678
               W  IP  DP VL++    QD R   +IPL   +++V P  + R     V++LQ + 
Sbjct: 562 GPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTVGPQGDPR-----VFQLQQSG 616

Query: 679 QSWYLSASSAELQQQWLETLSTAAHG 704
           Q +   A + EL+ +W++ +  AA G
Sbjct: 617 QLYTFKAETEELKGRWVKAMERAASG 642


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score =  210 bits (535), Expect = 3e-54
 Identities = 162/583 (27%), Positives = 262/583 (44%), Gaps = 76/583 (13%)

Query: 113  LDSQVPKVTPQEEADSDVGEEPDSENTP--QKADKDAGLAQHSGPQKLLHIAQELLHTEE 170
            L S   ++    + D    E    E  P   K D+D G+       K+ HIA+E++ +E+
Sbjct: 830  LPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQDEDNGMKS-----KVHHIAKEIMSSEK 884

Query: 171  TYVKRLHLLDQVFCTRLTDAG-------IPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223
             +V  L LL   F   +  A        I   ++  I   +  ++  +   LL EL+ R+
Sbjct: 885  VFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRD-LLKELEERM 943

Query: 224  TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283
               W    R+ DI  K  P+LKMY  Y+K FD+ + L+    +++P F  VV   +    
Sbjct: 944  LH-WTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPR 1002

Query: 284  CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343
            C NL L+H++L+PVQR+P+Y LLL DYLK L +DA D +D + +L ++   ANH+N  ++
Sbjct: 1003 CANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMK 1062

Query: 344  KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403
            + +   KL+++   L G  +IV P    +KEG + KLS K    Q R  FLFN  +LY  
Sbjct: 1063 QGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRK--VMQPRMFFLFNDALLYTT 1120

Query: 404  PKLRLMGQKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQI 463
            P   +    + +   + ++G++V+   +    +   I   +RS  L   +  E+ EW++ 
Sbjct: 1121 P---VQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEA 1177

Query: 464  IQATIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPR 523
            I   IE++ +   TF            PS S D    + S  +  V+  GS     +   
Sbjct: 1178 ISRAIEEYAKKRITF-----------CPSRSLD---EADSENKEEVSPLGSKAPIWIP-- 1221

Query: 524  KLSSKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAE----NSRQSRV 579
                    D     C  C   F ++T RRHHC+ CG ++C  CS  K       ++ +RV
Sbjct: 1222 --------DTRATMCMICTSEF-TLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARV 1272

Query: 580  CRDCFLTQPVAPESTEKTPTADPQPSLLCG-PLRLSESGETWSEVWAAIPMSDPQVLHLQ 638
            C  CF          ++    D Q S   G P          S V  +IP          
Sbjct: 1273 CEHCF----------QELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIP---------- 1312

Query: 639  GGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSW 681
                 GR  + IP    ++S  + E+   SG++++ +  K+ W
Sbjct: 1313 ----SGRKQKKIPAALKEVSA-NTEDSSMSGYLYRSKGNKKPW 1350


>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
          Length = 1462

 Score =  171 bits (432), Expect = 3e-42
 Identities = 163/700 (23%), Positives = 281/700 (40%), Gaps = 110/700 (15%)

Query: 66   SGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKVTPQEE 125
            S +L   N + G    SS      F   E  +         A+ E      +    P+E+
Sbjct: 808  SRALSTANENDGYVDMSS------FNAFESKQQSADQDAESAYTEPYKVCPISSAAPKED 861

Query: 126  ADSDVGEEPDSENTPQKADKDAGLAQH-SGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184
              SD  EE  S      A +D  +     G  + L IAQELL +E+ YV+ L  L+  F 
Sbjct: 862  LTSD--EEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFH 919

Query: 185  TRLTDA----------GIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLG 234
              +  A           +  E +    S + +IH  H Q +L EL+ R++  W++  ++ 
Sbjct: 920  GAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLH-QGILEELEERLSN-WESQQKVA 977

Query: 235  DILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHML 294
            D+          +  ++  FDR +GL+S     SP     V   ++    G+ T +H +L
Sbjct: 978  DVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLL 1037

Query: 295  EPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEV 354
              VQR+ +Y++LL DYL  L  D+ +  + + +L LIS   + +N ++ + E + KL+ +
Sbjct: 1038 RVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHI 1097

Query: 355  YEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFS 414
               + G+ D++ P  E +KEG + K++ KN  P  RHLFL N ++LY  P+      K+ 
Sbjct: 1098 EHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRP--RHLFLMNDVLLYTYPQ---KDGKYR 1152

Query: 415  VREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQN 474
            ++  + ++ ++V   V     +   I   +  L L   +  E+ EW   +   + +    
Sbjct: 1153 LKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYGCLSRALPE-DYK 1211

Query: 475  SETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKE 534
            ++   AF  +    E   +S      +  PV  V+                         
Sbjct: 1212 AQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVM------------------------- 1246

Query: 535  KQSCKSCGETFNSITKRRHHCKLCGAVICGKCSE----FKAENSRQSRVCRDCF------ 584
               C +CG  F S+T RRHHC  CG ++C  CS      K    R ++VC  CF      
Sbjct: 1247 --MCMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKR 1303

Query: 585  -------------------------------LTQPVAPESTEKTP---------TADPQP 604
                                           + Q + P + +K            A  + 
Sbjct: 1304 GRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEG 1363

Query: 605  SLLCGPLRLSESGET-WSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVPDPE 663
            S + G L   + G+  W ++W  I     +VL+    S+D     ++PL    ++    E
Sbjct: 1364 SAISGYLSRCKRGKRHWKKLWFVI---KGKVLYTYMASEDKVALESMPLLGFTIAPEKEE 1420

Query: 664  ERLDSGHVWKLQWAKQSWY-LSASSAELQQQWLETLSTAA 702
               + G ++ L   K  +Y   A      Q+W+E +  A+
Sbjct: 1421 GSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDAS 1460


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
            [Homo sapiens]
          Length = 1045

 Score =  126 bits (316), Expect = 8e-29
 Identities = 130/595 (21%), Positives = 240/595 (40%), Gaps = 78/595 (13%)

Query: 118  PKVTPQ-EEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRL 176
            P ++P  ++A   +    + +  P+  D+D G  +     K   IA+E+  TE TY+K L
Sbjct: 500  PNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDL 559

Query: 177  HLLDQVFCTRLTDAGIPPEVIMG-IFSNISSIHRFHGQFLLPELKTRITEEWDTNP---- 231
             ++   F + ++     PE +   IF N   +H+FH  FL  E++ R+   W+       
Sbjct: 560  EVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFL-KEIEQRLAL-WEGRSNAQI 617

Query: 232  ----RLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNL 287
                R+GD++ K    +K    ++     A+  +    + S   ++     + Q+VC  L
Sbjct: 618  RDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVC-YL 676

Query: 288  TLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEK 347
             L   +L P+ R+  Y+ +L+   K  P    D +D   +L  I+      +  + K+E 
Sbjct: 677  PLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMEN 736

Query: 348  MHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLR 407
              KL E+ + L G +++V P  E I+ G + KLS K    Q R  FLFN ++LY    L 
Sbjct: 737  FQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKG--LQQRMFFLFNDVLLYTSRGLT 794

Query: 408  LMGQKFSVREKMDISGLQVQDIVKP-NTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQA 466
               Q F V  ++ + G+ +++        H   + G+++S+ +   +  E ++W+     
Sbjct: 795  ASNQ-FKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWV----- 848

Query: 467  TIEKHKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLS 526
                                  ED  ++ D+   S+SP    + +      +  E     
Sbjct: 849  ----------------------EDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEA---- 882

Query: 527  SKTRRDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLT 586
              T  D+E +   S   T  S+ ++  H       +C           R + V    F  
Sbjct: 883  --TAADQESEDDLSASRT--SLERQAPHRGNTMVHVCWH---------RNTSVSMVDF-- 927

Query: 587  QPVAPESTEKTPTADPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRL 646
              +A E+            L    LR  ++   W ++W          L      QD   
Sbjct: 928  -SIAVEN-----------QLSGNLLRKFKNSNGWQKLWVVFTNF---CLFFYKSHQDNHP 972

Query: 647  PRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTA 701
              ++PL    L++P   E +   +V+KL +    +Y  A S    ++W+E + +A
Sbjct: 973  LASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSA 1027


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score =  124 bits (311), Expect = 3e-28
 Identities = 125/487 (25%), Positives = 202/487 (41%), Gaps = 39/487 (8%)

Query: 8   STPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSG 67
           S  P  +   G+P+    SSSL   Q   V  ++   +  S A AG   PD      L  
Sbjct: 408 SLSPSTLVPSGLPEFKDSSSSLTDPQVSYV--KSPAAERRSGAVAG--GPDTPSAQPLGP 463

Query: 68  SLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKVTPQEEAD 127
               P       SP  S +    P    L   P+  V    AE      +  V       
Sbjct: 464 PALQPGPGLSTKSPQPSPSSRKSP----LSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGA 519

Query: 128 SDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRL 187
               EEP  +  P                +   I +E+L TE TY+K L ++   F + +
Sbjct: 520 GMDCEEPRHKRVPA--------------DEAYFIVKEILATERTYLKDLEVITVWFRSAV 565

Query: 188 TDAGIPPEVIMGI-FSNISSIHRFHGQFLLPELKTRITEEWD---------TNPRLGDIL 237
                 P  +M + FSNI  I+ FH  FL  E++ R+   W+         ++ R+GDIL
Sbjct: 566 VKEDAMPATLMTLLFSNIDPIYEFHRGFLR-EVEQRLAL-WEGPSKAHTKGSHQRIGDIL 623

Query: 238 QKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPV 297
            +    LK +  Y +  D  +  +   T+R    + V    + Q+VC  L L   +L+P+
Sbjct: 624 LRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVC-YLPLNTFLLKPI 682

Query: 298 QRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQ 357
           QR+  Y LLL+           D  D   +L+ I+         + ++E + KL E+   
Sbjct: 683 QRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRD 742

Query: 358 LGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVRE 417
           L G E+++ P  E I+EG + KL+ K    Q R  FLF+ M+LY   K       F +R 
Sbjct: 743 LVGIENLIAPGREFIREGCLHKLTKKG--LQQRMFFLFSDMLLY-TSKGVAGTSHFRIRG 799

Query: 418 KMDISGLQVQDIVKP-NTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSE 476
            + + G+ V++     +  H F I   ++++ +   T  EK++W+  + + I+  K   +
Sbjct: 800 LLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGD 859

Query: 477 TFKAFGG 483
           T  A  G
Sbjct: 860 TAPALPG 866


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  112 bits (281), Expect = 9e-25
 Identities = 89/343 (25%), Positives = 159/343 (46%), Gaps = 43/343 (12%)

Query: 159 LHIAQELLHTEETYVKRLHLLDQVFCTRL-------TDAGIPPEVIMGIFSNISSIHRFH 211
           L +  E+L TE  YV  L  L   F  R+        + G+  E +  +FSNI  I   H
Sbjct: 51  LCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVH 110

Query: 212 GQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTW----TQR 267
             FL   L+  +  E  +   LG++  K      +Y EY  N ++A+ L+       T R
Sbjct: 111 KDFLAA-LEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVR 169

Query: 268 SPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERS 327
           + L   ++   +K     ++ L+ ++L P+QR+ +Y LLLK+  KR P   PD    + +
Sbjct: 170 AFLLSCMLLGGRKTT---DIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSA 226

Query: 328 LELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEE--DIVNPANELIKEGQIQKLSAKNG 385
           L+ + T  ++ N   R++EK+  L ++   + G E  ++ +   +L+ +G + K+SA  G
Sbjct: 227 LQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA--G 284

Query: 386 TPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMDISGL----------------QVQDI 429
             Q+R  FLF+++++YC  K R+ G K S +    I+G                  V+D 
Sbjct: 285 NIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG 344

Query: 430 VKPNTAHTFII--------TGRKRSLELQTRTEEEKKEWIQII 464
                ++ + +        T + +      +T EEK++W+  I
Sbjct: 345 TADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAI 387


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  101 bits (252), Expect = 2e-21
 Identities = 82/303 (27%), Positives = 138/303 (45%), Gaps = 22/303 (7%)

Query: 116  QVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQH-----SGPQKLL--HIAQELLHT 168
            +VP   P +     +   P +E  P +A + A          S PQ  +  H+A  LL T
Sbjct: 1018 EVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDT 1077

Query: 169  EETYVKRLHLLDQVFCTRLTDAG----IPPEVIMGIFSNISSIHRFHGQFLLPELKTRIT 224
            E++YV+ L  L Q +   L          P ++  IF  I  +   H QFL  E      
Sbjct: 1078 EQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL--EQVRHCM 1135

Query: 225  EEWDTNPRLGDILQKLAP---FLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQ 281
            + W    ++G +L +       + +Y  Y+ NF  A   V    +  P F   +    ++
Sbjct: 1136 QTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRE 1195

Query: 282  EVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK---DAERSLELISTAANHS 338
                   L   M++PVQR+PRYELL+KD LK  P+D PD     +A+R+++ ++   N  
Sbjct: 1196 NK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKG 1254

Query: 339  NAAIRKVEKMHKLL-EVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNS 397
              +  + E+  ++L E+   + G ED+  P    +++  + ++ A  G  +DR LFLF  
Sbjct: 1255 VRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGG-KKDRSLFLFTD 1313

Query: 398  MIL 400
            +I+
Sbjct: 1314 LIV 1316


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 96/368 (26%), Positives = 159/368 (43%), Gaps = 34/368 (9%)

Query: 138 NTPQKADKDAGLAQHSGP------------QKLLHIAQELLHTEETYVKRLHLLDQVF-- 183
           N  + AD DA LA +SG             Q   ++  E+L TE  Y+K L  + + +  
Sbjct: 253 NQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVR 312

Query: 184 -CTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKLAP 242
            C +  D     E +  IF NI  I+R    F+   L+ R   E      LG    +   
Sbjct: 313 QCRKRADM-FSEEQLRTIFGNIEDIYRCQKAFV-KALEQRFNRERPHLSELGACFLEHQA 370

Query: 243 FLKMYGEYVKNFDRAVGLVSTWTQRSPL--FKDVVHSIQKQEVCGNLTLQHHMLEPVQRV 300
             ++Y EY  N   A   +S  T+ S    F +    +QK     +++L   +L PVQ++
Sbjct: 371 DFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMI---DISLDGFLLTPVQKI 427

Query: 301 PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG 360
            +Y L L + LK       D KD E +L  +   A   N   R++E + K+ +    +  
Sbjct: 428 CKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIED 487

Query: 361 --EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREK 418
              ED++  ++ELI  G++ +++      Q R  FLF+  ++YC   L L       + +
Sbjct: 488 WEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDL-LRRDVLYYKGR 546

Query: 419 MDISGLQVQDIV--KPNTAHTFIITGRK-------RSLELQTRTEEEKKEWIQIIQATIE 469
           +D+ GL+V D+   K    H  I    +        S  L TR  E+K+ W++      E
Sbjct: 547 LDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFARERE 606

Query: 470 KHKQNSET 477
           + + + ET
Sbjct: 607 QVQLDQET 614


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 96/368 (26%), Positives = 159/368 (43%), Gaps = 34/368 (9%)

Query: 138 NTPQKADKDAGLAQHSGP------------QKLLHIAQELLHTEETYVKRLHLLDQVF-- 183
           N  + AD DA LA +SG             Q   ++  E+L TE  Y+K L  + + +  
Sbjct: 253 NQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVR 312

Query: 184 -CTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKLAP 242
            C +  D     E +  IF NI  I+R    F+   L+ R   E      LG    +   
Sbjct: 313 QCRKRADM-FSEEQLRTIFGNIEDIYRCQKAFV-KALEQRFNRERPHLSELGACFLEHQA 370

Query: 243 FLKMYGEYVKNFDRAVGLVSTWTQRSPL--FKDVVHSIQKQEVCGNLTLQHHMLEPVQRV 300
             ++Y EY  N   A   +S  T+ S    F +    +QK     +++L   +L PVQ++
Sbjct: 371 DFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMI---DISLDGFLLTPVQKI 427

Query: 301 PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG 360
            +Y L L + LK       D KD E +L  +   A   N   R++E + K+ +    +  
Sbjct: 428 CKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIED 487

Query: 361 --EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREK 418
              ED++  ++ELI  G++ +++      Q R  FLF+  ++YC   L L       + +
Sbjct: 488 WEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDL-LRRDVLYYKGR 546

Query: 419 MDISGLQVQDIV--KPNTAHTFIITGRK-------RSLELQTRTEEEKKEWIQIIQATIE 469
           +D+ GL+V D+   K    H  I    +        S  L TR  E+K+ W++      E
Sbjct: 547 LDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFARERE 606

Query: 470 KHKQNSET 477
           + + + ET
Sbjct: 607 QVQLDQET 614


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 84/344 (24%), Positives = 157/344 (45%), Gaps = 38/344 (11%)

Query: 161 IAQELLHTEETYVKRLHLLDQVFCTRLT-------DAGIPPEVIMGIFSNISSIHRFHGQ 213
           +  EL  TE  YV  L  L   F  R+        D  +  E +  +FSNI  I   H +
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 214 FLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLV----STWTQRSP 269
           FL   ++  +  E +    +G          ++Y EY  N ++A  L+       T R+ 
Sbjct: 87  FL-KVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTF 145

Query: 270 LFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLE 329
           L   ++   +K     ++ L+ +++ P+QR+ +Y L+LK+ LKR P+   D      +L+
Sbjct: 146 LLNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 330 LISTAANHSNAAIRKVEKMHKLLEVYEQLGGEE--DIVNPANELIKEGQIQKLSAKNGTP 387
            +    ++ N A R++EK+  L E    + G E  +I +   E++  G + K+S  +G  
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNI 260

Query: 388 QDRHLFLFNSMILYCVPKLRLM--------GQKFSVREKMDISGLQVQDIVK-----PNT 434
           Q+R  FLF+++++YC  K R +        G ++  R +++   ++V+++        ++
Sbjct: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320

Query: 435 AHTFI------ITGRKRSLELQTRTEEEKKEWIQIIQATIEKHK 472
            H  +       T + +      +T EEK EW + I    E+ K
Sbjct: 321 GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRK 364


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 84/344 (24%), Positives = 157/344 (45%), Gaps = 38/344 (11%)

Query: 161 IAQELLHTEETYVKRLHLLDQVFCTRLT-------DAGIPPEVIMGIFSNISSIHRFHGQ 213
           +  EL  TE  YV  L  L   F  R+        D  +  E +  +FSNI  I   H +
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 214 FLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLV----STWTQRSP 269
           FL   ++  +  E +    +G          ++Y EY  N ++A  L+       T R+ 
Sbjct: 87  FL-KVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTF 145

Query: 270 LFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLE 329
           L   ++   +K     ++ L+ +++ P+QR+ +Y L+LK+ LKR P+   D      +L+
Sbjct: 146 LLNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 330 LISTAANHSNAAIRKVEKMHKLLEVYEQLGGEE--DIVNPANELIKEGQIQKLSAKNGTP 387
            +    ++ N A R++EK+  L E    + G E  +I +   E++  G + K+S  +G  
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNI 260

Query: 388 QDRHLFLFNSMILYCVPKLRLM--------GQKFSVREKMDISGLQVQDIVK-----PNT 434
           Q+R  FLF+++++YC  K R +        G ++  R +++   ++V+++        ++
Sbjct: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320

Query: 435 AHTFI------ITGRKRSLELQTRTEEEKKEWIQIIQATIEKHK 472
            H  +       T + +      +T EEK EW + I    E+ K
Sbjct: 321 GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRK 364


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 100/444 (22%), Positives = 191/444 (43%), Gaps = 37/444 (8%)

Query: 39   PRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEA 98
            P+    D  S    G+  PD      L   +KI + D   D  SSS+        E   A
Sbjct: 1813 PQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTA 1872

Query: 99   GPSPTVLGAHAEMALDSQVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKL 158
                  +    +  L  +        +  +    E  +  TP K  ++   A+    +  
Sbjct: 1873 ADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAK--ALRGR 1930

Query: 159  LHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMG----IFSNISSIHRFHGQF 214
            + +  EL+ TE+ YVK L ++ + F  R+ + G+P E + G    +F NI  I+ +H  F
Sbjct: 1931 MFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVP-EDMRGKDKIVFGNIHQIYDWHKDF 1989

Query: 215  LLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDV 274
             L EL+  I E+     RL  +  K    L +Y  Y +N  R+  +V+ +      F++V
Sbjct: 1990 FLAELEKCIQEQ----DRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY---DAYFEEV 2042

Query: 275  VHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTA 334
                 KQE+   LTL   +++P+QR+ +Y+LLLKD+L+   +   +  D E+++EL+   
Sbjct: 2043 -----KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097

Query: 335  ANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNG---TPQDRH 391
                N  +              +L G E  +    +L+++     +    G     ++R 
Sbjct: 2098 PKRCNDMMN-----------LGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERR 2146

Query: 392  LFLFNSMILYC-VPKLRLMGQKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRS--LE 448
            +FLF  ++++  + +   +   +  +  + ++ L +++ V  N    F +  R+ S  + 
Sbjct: 2147 VFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENV-DNDPCKFALMNRETSERVV 2205

Query: 449  LQTRTEEEKKEWIQIIQATIEKHK 472
            LQ    + ++ W+Q I   +E  +
Sbjct: 2206 LQAANADIQQAWVQDINQVLETQR 2229



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 92/349 (26%), Positives = 158/349 (45%), Gaps = 39/349 (11%)

Query: 135  DSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDA--GI 192
            D E   + A+ +    +    +K   I  ELL TE+ YV+ LH   + +   +T     I
Sbjct: 1259 DREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEI 1318

Query: 193  PPEVIMG---IFSNISSIHRFHGQFLLPELKTRITEEWDTNPR-LGDILQKLAPFLKMYG 248
            PP ++     IF NI  I+ FH    L EL     E+++  P  +G      A   +MY 
Sbjct: 1319 PPGILNKEHIIFGNIQEIYDFHNNIFLKEL-----EKYEQLPEDVGHCFVTWADKFQMYV 1373

Query: 249  EYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLK 308
             Y KN   +  L+    + +  F D    IQ++    N ++  ++++PVQR+ +Y+LLLK
Sbjct: 1374 TYCKNKPDSNQLI---LEHAGTFFD---EIQQRHGLAN-SISSYLIKPVQRITKYQLLLK 1426

Query: 309  DYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPA 368
            + L    +   + KD    LE++ +    +N A      MH        L G ++ ++  
Sbjct: 1427 ELLTCCEEGKGELKD---GLEVMLSVPKKANDA------MH-----VSMLEGFDENLDVQ 1472

Query: 369  NELIKEGQIQKLSAKN--GTPQDRHLFLFNSMILYCVPKLRLMGQ-KFSVREKMDISGLQ 425
             ELI +   Q    K+     ++RHLFLF   +++        G  K+  + K+  S L 
Sbjct: 1473 GELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELG 1532

Query: 426  VQDIVKPNTAHTFIITGRKRSLE----LQTRTEEEKKEWIQIIQATIEK 470
            V + V+ +     + +GR  S +    L+    E K+EWI+ I+  I++
Sbjct: 1533 VTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQE 1581


>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
          Length = 1289

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 100/444 (22%), Positives = 191/444 (43%), Gaps = 37/444 (8%)

Query: 39  PRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEA 98
           P+    D  S    G+  PD      L   +KI + D   D  SSS+        E   A
Sbjct: 116 PQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTA 175

Query: 99  GPSPTVLGAHAEMALDSQVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKL 158
                 +    +  L  +        +  +    E  +  TP K  ++   A+    +  
Sbjct: 176 ADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEEEQKAK--ALRGR 233

Query: 159 LHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMG----IFSNISSIHRFHGQF 214
           + +  EL+ TE+ YVK L ++ + F  R+ + G+P E + G    +F NI  I+ +H  F
Sbjct: 234 MFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVP-EDMRGKDKIVFGNIHQIYDWHKDF 292

Query: 215 LLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDV 274
            L EL+  I E+     RL  +  K    L +Y  Y +N  R+  +V+ +      F++V
Sbjct: 293 FLAELEKCIQEQ----DRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEY---DAYFEEV 345

Query: 275 VHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTA 334
                KQE+   LTL   +++P+QR+ +Y+LLLKD+L+   +   +  D E+++EL+   
Sbjct: 346 -----KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400

Query: 335 ANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNG---TPQDRH 391
               N  +              +L G E  +    +L+++     +    G     ++R 
Sbjct: 401 PKRCNDMMN-----------LGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERR 449

Query: 392 LFLFNSMILYC-VPKLRLMGQKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRS--LE 448
           +FLF  ++++  + +   +   +  +  + ++ L +++ V  N    F +  R+ S  + 
Sbjct: 450 VFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENV-DNDPCKFALMNRETSERVV 508

Query: 449 LQTRTEEEKKEWIQIIQATIEKHK 472
           LQ    + ++ W+Q I   +E  +
Sbjct: 509 LQAANADIQQAWVQDINQVLETQR 532


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 83/317 (26%), Positives = 136/317 (42%), Gaps = 29/317 (9%)

Query: 118 PKVTPQEEADSDVGEEPDSENTPQ---------KADKDAGLAQHSGPQKLL---HIAQEL 165
           P+  P  E    +G   D  NTP+         K+   +  +    P K      +A+EL
Sbjct: 370 PRKRPSAEHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAKEL 429

Query: 166 LHTEETYVKRLHLLDQVFCTRLTDAG------IPPEVIMGIFSNISSIHRFHGQFLLPEL 219
             TE  YV  L  + Q+F   L + G      + PE I  IF +I  I   H + +  +L
Sbjct: 430 YQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK-IKDDL 488

Query: 220 KTRITEEWDTNPRLGDILQKLAPFL-KMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSI 278
           +  I   WD +  +GDI  K +  L K Y  +V  F+ +   +    ++ P F   +   
Sbjct: 489 EDLIVN-WDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAFLKIN 547

Query: 279 QKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHS 338
           Q +  CG  +L   ++ PVQR+P   LLL D  K    + PD+   E+++  +     H 
Sbjct: 548 QAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEVMTHI 607

Query: 339 NAAIRKVEKMHKLLE-VYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDR----HLF 393
           N   RK E   ++ + VYE  G   ++++    L++  +   L      P DR     LF
Sbjct: 608 NEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEH---PCDRGEQVTLF 664

Query: 394 LFNSMILYCVPKLRLMG 410
           LFN  +     + +++G
Sbjct: 665 LFNDCLEIARKRHKVIG 681


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 1 [Homo sapiens]
          Length = 1279

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 76/303 (25%), Positives = 145/303 (47%), Gaps = 40/303 (13%)

Query: 124 EEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLL--HIAQELLHTEETYVKRLHLLDQ 181
           EE D  + E   S+  P  A +   + +   PQ+++  HI   ++ +E +YV+ L  + Q
Sbjct: 282 EEEDMGLLEVSVSDIKPP-APELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQ 340

Query: 182 VFCTRLTDAGIPPEVIMG-----IFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDI 236
            +   L +  + P+ +       +F  +  I   H  F +  L +R+ E WD+  ++GD+
Sbjct: 341 DYRNPLME--MEPKALSARKCQVVFFRVKEILHCHSMFQIA-LSSRVAE-WDSTEKIGDL 396

Query: 237 LQKLAPFLK-----MYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCG--NLTL 289
              +A F K     +Y +YV NF  A+ ++       P F +    +++++VC    +TL
Sbjct: 397 F--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEF---LKRRQVCSPDRVTL 451

Query: 290 QHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMH 349
              M++P+QR P++ LLL+D LK  P+  PDR   + +L  + T A   N   R  +++ 
Sbjct: 452 YGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVA 511

Query: 350 KLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGT------------PQDRHLFLFNS 397
           ++ ++ + +     +    N+L+  GQ Q L  +  T             ++R +FL N 
Sbjct: 512 EIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLND 567

Query: 398 MIL 400
           M++
Sbjct: 568 MLV 570


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 2 [Homo sapiens]
          Length = 1240

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 76/303 (25%), Positives = 145/303 (47%), Gaps = 40/303 (13%)

Query: 124 EEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLL--HIAQELLHTEETYVKRLHLLDQ 181
           EE D  + E   S+  P  A +   + +   PQ+++  HI   ++ +E +YV+ L  + Q
Sbjct: 243 EEEDMGLLEVSVSDIKPP-APELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQ 301

Query: 182 VFCTRLTDAGIPPEVIMG-----IFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDI 236
            +   L +  + P+ +       +F  +  I   H  F +  L +R+ E WD+  ++GD+
Sbjct: 302 DYRNPLME--MEPKALSARKCQVVFFRVKEILHCHSMFQIA-LSSRVAE-WDSTEKIGDL 357

Query: 237 LQKLAPFLK-----MYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCG--NLTL 289
              +A F K     +Y +YV NF  A+ ++       P F +    +++++VC    +TL
Sbjct: 358 F--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEF---LKRRQVCSPDRVTL 412

Query: 290 QHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMH 349
              M++P+QR P++ LLL+D LK  P+  PDR   + +L  + T A   N   R  +++ 
Sbjct: 413 YGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVA 472

Query: 350 KLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGT------------PQDRHLFLFNS 397
           ++ ++ + +     +    N+L+  GQ Q L  +  T             ++R +FL N 
Sbjct: 473 EIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLND 528

Query: 398 MIL 400
           M++
Sbjct: 529 MLV 531


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 89/396 (22%), Positives = 170/396 (42%), Gaps = 46/396 (11%)

Query: 101  SPTVLGAHAEMALDSQVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGP----- 155
            S T   A    A++  V      E+  S +  +    ++P     D  L   S P     
Sbjct: 1901 SETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEME 1960

Query: 156  -------QKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMG---IFSNIS 205
                   ++  ++ QEL+ TE  YV+ L  + + +   + + G+P ++      +F NI 
Sbjct: 1961 ERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIH 2020

Query: 206  SIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWT 265
             I+ +H  F L EL+  + +      +LG +  K    L MY  Y +N  ++  +VS + 
Sbjct: 2021 QIYDWHRDFFLGELEKCLEDP----EKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYI 2076

Query: 266  QRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAE 325
                 F+D+     KQ +   L L   +++PVQR+ +Y+LLLKD+LK   + + D  + E
Sbjct: 2077 DT--FFEDL-----KQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELE 2129

Query: 326  RSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNG 385
            R++E++       N           ++ V    G +  IV     L+++  +        
Sbjct: 2130 RAVEVMCIVPRRCN----------DMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGL 2179

Query: 386  TP--QDRHLFLFNSMILYCVPKLRLMG---QKFSVREKMDISGLQVQDIVKPNTAHTFII 440
             P  ++R +FLF  ++++  P  +  G     F  +  + +S L +++ V+ N    F +
Sbjct: 2180 LPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVE-NDPCKFAL 2238

Query: 441  TGRK----RSLELQTRTEEEKKEWIQIIQATIEKHK 472
            T R      +  L + +   ++ WI  I   +E  +
Sbjct: 2239 TSRTGDVVETFILHSSSPSVRQTWIHEINQILENQR 2274



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 89/373 (23%), Positives = 162/373 (43%), Gaps = 39/373 (10%)

Query: 111  MALDSQVPKVTPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEE 170
            + + S   K +   + D      P SE   + A  +    +    ++   I  EL+ TE+
Sbjct: 1246 LGISSDSNKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEK 1305

Query: 171  TYVKRLHLLDQVFCTRLTDA--GIPPEVI---MGIFSNISSIHRFHGQFLLPELKTRITE 225
             YV+ L      +   +T     IPP ++   + IF N+  I+ FH    L EL     E
Sbjct: 1306 AYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKEL-----E 1360

Query: 226  EWDTNPR-LGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVC 284
            +++  P  +G      A   +MY  Y KN   +  L+    + +  + D    IQ++   
Sbjct: 1361 KYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLI---LEHAGSYFD---EIQQRHGL 1414

Query: 285  GNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRK 344
             N ++  ++++PVQR+ +Y+LLLK+ L    +   + KD    LE++ +    +N A   
Sbjct: 1415 AN-SISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKD---GLEVMLSVPKRANDA--- 1467

Query: 345  VEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKN--GTPQDRHLFLFNSMILYC 402
               MH        L G ++ +    ELI +   Q    K      ++RHLFLF   +++ 
Sbjct: 1468 ---MH-----LSMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFS 1519

Query: 403  VPKLRLMGQ-KFSVREKMDISGLQVQDIVKPNTAHTFIITGR----KRSLELQTRTEEEK 457
                   G+ K+  + K+  S L V + V+ +     +  GR       + L+  + E K
Sbjct: 1520 KEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENK 1579

Query: 458  KEWIQIIQATIEK 470
            ++WI+ I+  I++
Sbjct: 1580 QDWIKHIREVIQE 1592


>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo
           sapiens]
          Length = 619

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 99/402 (24%), Positives = 174/402 (43%), Gaps = 51/402 (12%)

Query: 14  IAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPN 73
           +A    P++   + S G + A      A    P S  ++G  SP  GP G +SG  +  +
Sbjct: 65  LAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLD 122

Query: 74  RDSGIDS----PSSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQE 124
                 S      S  AG  EN+  E  L  G   P  T+L    E   D   P   P+E
Sbjct: 123 HSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEE 179

Query: 125 EADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFC 184
           E    + + P+SE   +K             ++ +++  EL+ TE+ YV  L  + + + 
Sbjct: 180 ET---LSQAPESEEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYM 226

Query: 185 TRLTDAGIPPEVIMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQK 239
             +   G+P E + G    +F NI  I+ +H  + L EL+  + + +W     L  +  K
Sbjct: 227 ATMAAQGVP-ESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIK 280

Query: 240 LAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQR 299
               L MY  Y +N  ++  +VS        F D      +Q++   L L   +++PVQR
Sbjct: 281 HERRLHMYVVYCQNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQR 333

Query: 300 VPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLG 359
           + +Y+LLLKD+LK   +   D  D E+++E++       N     +  + +L     +L 
Sbjct: 334 IMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLT 389

Query: 360 GEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401
            +  ++      + E +   L +  G  ++R +FLF  +I++
Sbjct: 390 AQGKLLGQDTFWVTEPEAGGLLSSRG--RERRVFLFEQIIIF 429


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 73/330 (22%), Positives = 143/330 (43%), Gaps = 22/330 (6%)

Query: 164 ELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223
           E+  TE  Y + L  +++ + + L    + P  +  +F N+  + + H  FL   +   +
Sbjct: 200 EIQETEAKYYRTLEDIEKNYMSPLRLV-LSPADMAAVFINLEDLIKVHHSFLRA-IDVSV 257

Query: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283
                T   L  +       L +YGEY  + + A   ++        F+  V     +  
Sbjct: 258 MVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQ 314

Query: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343
            G   LQ  ++ P+QRV +Y LLLK+ L     + P+R+  + +LE +   A + N   R
Sbjct: 315 DGKFKLQDLLVVPMQRVLKYHLLLKELLSH-SAERPERQQLKEALEAMQDLAMYINEVKR 373

Query: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403
             E + K+ E    +   +  +        +G+++  S  N T QDR+LFLF+ +++ C 
Sbjct: 374 DKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCK 433

Query: 404 PKLRLMGQKFSVRE-------KMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEE 456
            K    G  + ++E       KM    +  +D+ K +     I    K+  +   +TE+ 
Sbjct: 434 RK----GYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDM 489

Query: 457 KKEWIQIIQATI-----EKHKQNSETFKAF 481
           K++W++  +  +     +K   N  +F+ +
Sbjct: 490 KRKWMEQFEMAMSNIKPDKANANHHSFQMY 519


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 618

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 90/386 (23%), Positives = 171/386 (44%), Gaps = 51/386 (13%)

Query: 121 TPQEEADSDVGEEPDS----ENTPQ-----------------KADKDAGLAQHSGPQ--K 157
           TP+EE + +  EEP S    +  PQ                    + +G+ +   P+  K
Sbjct: 122 TPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIK 181

Query: 158 LLHIAQELLHTEETYVKRLHLLDQVFCT--RLTDAGIPPEVIMGIFSNISSIHRFHGQFL 215
           L     EL+ +E +Y K L+LL   F    R+     P E  + +FSN+  +     +FL
Sbjct: 182 LQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHI-LFSNVLDVLAVSERFL 240

Query: 216 LPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVV 275
           L EL+ R+ E    +     + +  A    +Y  YV N            Q    F++++
Sbjct: 241 L-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELI 299

Query: 276 HSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK----DAERSLELI 331
             ++    C  L     ++ P QR+ R +LL+++ LKR+ ++  +R+    DA + LE++
Sbjct: 300 AQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRV-EERSERECTALDAHKELEMV 358

Query: 332 STAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDR- 390
             A N     + + E+M  + +  E       I++ +  L+K+G++Q++S    +   R 
Sbjct: 359 VKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRT 418

Query: 391 -------HLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVK--PNTAHTFII- 440
                  +LFLFN +++ C    ++ G K+ V +      L+V+++       A+ FI+ 
Sbjct: 419 KKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILR 475

Query: 441 -----TGRKRSLELQTRTEEEKKEWI 461
                  R+ +  L+  ++ E K W+
Sbjct: 476 LLENADDREATYMLKASSQSEMKRWM 501


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 710

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 90/386 (23%), Positives = 171/386 (44%), Gaps = 51/386 (13%)

Query: 121 TPQEEADSDVGEEPDS----ENTPQ-----------------KADKDAGLAQHSGPQ--K 157
           TP+EE + +  EEP S    +  PQ                    + +G+ +   P+  K
Sbjct: 214 TPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIK 273

Query: 158 LLHIAQELLHTEETYVKRLHLLDQVFCT--RLTDAGIPPEVIMGIFSNISSIHRFHGQFL 215
           L     EL+ +E +Y K L+LL   F    R+     P E  + +FSN+  +     +FL
Sbjct: 274 LQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHI-LFSNVLDVLAVSERFL 332

Query: 216 LPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVV 275
           L EL+ R+ E    +     + +  A    +Y  YV N            Q    F++++
Sbjct: 333 L-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELI 391

Query: 276 HSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK----DAERSLELI 331
             ++    C  L     ++ P QR+ R +LL+++ LKR+ ++  +R+    DA + LE++
Sbjct: 392 AQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRV-EERSERECTALDAHKELEMV 450

Query: 332 STAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDR- 390
             A N     + + E+M  + +  E       I++ +  L+K+G++Q++S    +   R 
Sbjct: 451 VKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRT 510

Query: 391 -------HLFLFNSMILYCVPKLRLMGQKFSVREKMDISGLQVQDIVK--PNTAHTFII- 440
                  +LFLFN +++ C    ++ G K+ V +      L+V+++       A+ FI+ 
Sbjct: 511 KKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILR 567

Query: 441 -----TGRKRSLELQTRTEEEKKEWI 461
                  R+ +  L+  ++ E K W+
Sbjct: 568 LLENADDREATYMLKASSQSEMKRWM 593


>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo
           sapiens]
          Length = 580

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 97/390 (24%), Positives = 169/390 (43%), Gaps = 51/390 (13%)

Query: 26  SSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIGPTGELSGSLKIPNRDSGIDS----P 81
           + S G + A      A    P S  ++G  SP  GP G +SG  +  +      S     
Sbjct: 38  AGSEGSISASAASGLAAPSGPSSGLSSGPCSP--GPPGPVSGLRRWLDHSKHCLSVETEA 95

Query: 82  SSSVAG--ENFPCEEGLEAG---PSPTVLGAHAEMALDSQVPKVTPQEEADSDVGEEPDS 136
            S  AG  EN+  E  L  G   P  T+L    E   D   P   P+EE    + + P+S
Sbjct: 96  DSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQP---PEEET---LSQAPES 149

Query: 137 ENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEV 196
           E   +K             ++ +++  EL+ TE+ YV  L  + + +   +   G+P E 
Sbjct: 150 EEEQKK----------KALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVP-ES 198

Query: 197 IMG----IFSNISSIHRFHGQFLLPELKTRITE-EWDTNPRLGDILQKLAPFLKMYGEYV 251
           + G    +F NI  I+ +H  + L EL+  + + +W     L  +  K    L MY  Y 
Sbjct: 199 LRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDW-----LAQLFIKHERRLHMYVVYC 253

Query: 252 KNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYL 311
           +N  ++  +VS        F D      +Q++   L L   +++PVQR+ +Y+LLLKD+L
Sbjct: 254 QNKPKSEHVVSE-------FGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFL 306

Query: 312 KRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANEL 371
           K   +   D  D E+++E++       N     +  + +L     +L  +  ++      
Sbjct: 307 KYYNRAGMDTADLEQAVEVMCFVPKRCN----DMMTLGRLRGFEGKLTAQGKLLGQDTFW 362

Query: 372 IKEGQIQKLSAKNGTPQDRHLFLFNSMILY 401
           + E +   L +  G  ++R +FLF  +I++
Sbjct: 363 VTEPEAGGLLSSRG--RERRVFLFEQIIIF 390


>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
          Length = 1663

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 92/349 (26%), Positives = 158/349 (45%), Gaps = 39/349 (11%)

Query: 135  DSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDA--GI 192
            D E   + A+ +    +    +K   I  ELL TE+ YV+ LH   + +   +T     I
Sbjct: 1259 DREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEI 1318

Query: 193  PPEVIMG---IFSNISSIHRFHGQFLLPELKTRITEEWDTNPR-LGDILQKLAPFLKMYG 248
            PP ++     IF NI  I+ FH    L EL     E+++  P  +G      A   +MY 
Sbjct: 1319 PPGILNKEHIIFGNIQEIYDFHNNIFLKEL-----EKYEQLPEDVGHCFVTWADKFQMYV 1373

Query: 249  EYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLK 308
             Y KN   +  L+    + +  F D    IQ++    N ++  ++++PVQR+ +Y+LLLK
Sbjct: 1374 TYCKNKPDSNQLI---LEHAGTFFD---EIQQRHGLAN-SISSYLIKPVQRITKYQLLLK 1426

Query: 309  DYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPA 368
            + L    +   + KD    LE++ +    +N A      MH        L G ++ ++  
Sbjct: 1427 ELLTCCEEGKGELKD---GLEVMLSVPKKANDA------MH-----VSMLEGFDENLDVQ 1472

Query: 369  NELIKEGQIQKLSAKN--GTPQDRHLFLFNSMILYCVPKLRLMGQ-KFSVREKMDISGLQ 425
             ELI +   Q    K+     ++RHLFLF   +++        G  K+  + K+  S L 
Sbjct: 1473 GELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELG 1532

Query: 426  VQDIVKPNTAHTFIITGRKRSLE----LQTRTEEEKKEWIQIIQATIEK 470
            V + V+ +     + +GR  S +    L+    E K+EWI+ I+  I++
Sbjct: 1533 VTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQE 1581


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 82/357 (22%), Positives = 164/357 (45%), Gaps = 31/357 (8%)

Query: 130 VGEEPDSEN---TP-QKADKDAGLAQH----SGPQKLLHIAQELLHTEETYVKRLHLLDQ 181
           V +E  SEN   TP ++ D++A  ++H    +  Q   ++ +E++ TE  Y+K L  + +
Sbjct: 205 VNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICE 264

Query: 182 VF---CTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQ 238
            +   C + T      ++   IF NI  I++F  +FL  +L+ +  +E      +G    
Sbjct: 265 GYIRQCRKHTGMFTVAQLAT-IFGNIEDIYKFQRKFL-KDLEKQYNKEEPHLSEIGSCFL 322

Query: 239 KLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQ 298
           +      +Y EY  N   A   ++   ++   ++    + +  +   ++ +   +L PVQ
Sbjct: 323 QNQEGFAIYSEYCNNHPGACLELANLMKQGK-YRHFFEACRLLQQMIDIAIDGFLLTPVQ 381

Query: 299 RVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQL 358
           ++ +Y L L + LK   Q+  D  + + + E +   A   N   RK+E + K+      +
Sbjct: 382 KICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSI 441

Query: 359 GGEE--DIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVR 416
            G E  DI++ ++ELI  G++ K++ K G  Q R  FLF+  ++ C   L L       +
Sbjct: 442 VGWEGLDILDRSSELIHSGELTKIT-KQGKSQQRTFFLFDHQLVSCKKDL-LRRDMLYYK 499

Query: 417 EKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRT-----------EEEKKEWIQ 462
            ++D+  +++ D+         +    K + +L +RT           +E+K  W+Q
Sbjct: 500 GRLDMDEMELVDLGDGRDKDCNLSV--KNAFKLVSRTTDEVYLFCAKKQEDKARWLQ 554


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 87/362 (24%), Positives = 164/362 (45%), Gaps = 27/362 (7%)

Query: 121 TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHI---AQELLHTEETYVKRLH 177
           T Q+ AD      P ++           +A  +   KLL++    QE+L TE TYV+ L 
Sbjct: 74  TGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLK 133

Query: 178 LL--DQVFCTR-LTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNP-RL 233
            +  D + C R  T   +  E    +F NI  I+ F+ + LL +L     E  + +P  +
Sbjct: 134 SIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSE-LLQDL-----ENCENDPVAI 187

Query: 234 GDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHM 293
            +     +    +Y +Y  N+ R+V +++   +   L K      +++ +  +L L  ++
Sbjct: 188 AECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAK--FFRERQETLKHSLPLGSYL 245

Query: 294 LEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLE 353
           L+PVQR+ +Y LLL +    L +D         +++ +   A H N   RK E   +L E
Sbjct: 246 LKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQE 305

Query: 354 VYEQL-GGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQK 412
           +   L   +   +    EL+ EG  +   AKN    +R LFLF+ ++L  + K R     
Sbjct: 306 IQSLLTNWKGPDLTSYGELVLEGTFRIQRAKN----ERTLFLFDKLLL--ITKKR--DDT 357

Query: 413 FSVREKMDISGLQVQDIV--KPNTAHTFIITGRKRSLELQTRTEEEKKEWI-QIIQATIE 469
           F+ +  +    L + +++  +P +   F     K    +Q +++++K+ W+  + +  +E
Sbjct: 358 FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILE 417

Query: 470 KH 471
            H
Sbjct: 418 NH 419


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 85/339 (25%), Positives = 150/339 (44%), Gaps = 45/339 (13%)

Query: 148 GLAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGI---PPEVIMGIFSNI 204
           G+   + P +L  +A+E++ TE  YV+ L  + + +   L D G+     E +  +F+NI
Sbjct: 93  GIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANI 152

Query: 205 SSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQ---KLAPFLKMYGEYVKNFDRAVGLV 261
             I+ F  + L         E+ + +   G I +   + +    +Y  Y  N+  ++ L+
Sbjct: 153 EDIYEFSSELL---------EDLENSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALL 203

Query: 262 STWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQ--DAP 319
              +   P    +    ++ ++  +L LQ  +L+PVQR+ +Y LLL++  K   +     
Sbjct: 204 RELSLSPPAALWLQE--RQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTG 261

Query: 320 DRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG-EEDIVNPANELIKEGQIQ 378
            R+  E ++  ++  A + N   RK E   +L EV  +LGG     ++   EL+ EG  +
Sbjct: 262 GREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFR 321

Query: 379 KLSAKNGTPQ----DRHLFLFNSMILYC-------VPKLRLMGQKFSVREK-MDISGLQV 426
                 G P+    +R LFLF+ M+L           K  +     SV E   D  G +V
Sbjct: 322 --GGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHIFCCNLSVSESPRDPLGFKV 379

Query: 427 QDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQ 465
            D+  P   H            LQ + +EEK+ WI  +Q
Sbjct: 380 SDLTIPKHRHL-----------LQAKNQEEKRLWIHCLQ 407


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,231,213
Number of Sequences: 37866
Number of extensions: 1705374
Number of successful extensions: 7903
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 211
Number of HSP's that attempted gapping in prelim test: 7209
Number of HSP's gapped (non-prelim): 766
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.