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Search of human proteins with 55743151
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55743151 WD repeat domain 19 [Homo sapiens]
(1342 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55743151 WD repeat domain 19 [Homo sapiens] 2722 0.0
gi|209969680 Fzr1 protein isoform 1 [Homo sapiens] 60 2e-08
gi|33620742 Fzr1 protein isoform 2 [Homo sapiens] 60 2e-08
gi|41281447 intraflagellar transport 140 [Homo sapiens] 57 1e-07
gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens] 57 2e-07
gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens] 56 2e-07
gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens] 56 2e-07
gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens] 56 2e-07
gi|46358428 selective LIM binding factor homolog [Homo sapiens] 49 2e-05
gi|118402582 cell division cycle 20 [Homo sapiens] 49 4e-05
gi|209969678 Fzr1 protein isoform 3 [Homo sapiens] 49 4e-05
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 45 4e-04
gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform ... 44 8e-04
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1... 44 8e-04
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 40 0.012
gi|44917606 N-ethylmaleimide-sensitive factor attachment protein... 38 0.057
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 37 0.098
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 37 0.098
gi|113865883 WD repeat domain 38 [Homo sapiens] 37 0.13
gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Ho... 37 0.13
gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [H... 37 0.13
gi|223029510 echinoderm microtubule associated protein like 4 is... 37 0.13
gi|19923497 echinoderm microtubule associated protein like 4 iso... 37 0.13
gi|47933379 N-ethylmaleimide-sensitive factor attachment protein... 36 0.28
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 36 0.28
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 36 0.28
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 36 0.28
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 35 0.37
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 35 0.37
gi|83415184 transmembrane and tetratricopeptide repeat containin... 35 0.37
>gi|55743151 WD repeat domain 19 [Homo sapiens]
Length = 1342
Score = 2722 bits (7057), Expect = 0.0
Identities = 1342/1342 (100%), Positives = 1342/1342 (100%)
Query: 1 MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGNCVAM 60
MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGNCVAM
Sbjct: 1 MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGNCVAM 60
Query: 61 DWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGN 120
DWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGN
Sbjct: 61 DWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGN 120
Query: 121 LLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDKMITVSNQEGDTIRQTQVRSE 180
LLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDKMITVSNQEGDTIRQTQVRSE
Sbjct: 121 LLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDKMITVSNQEGDTIRQTQVRSE 180
Query: 181 PSNMQFFLMKMDDRTSAAESMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWY 240
PSNMQFFLMKMDDRTSAAESMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWY
Sbjct: 181 PSNMQFFLMKMDDRTSAAESMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWY 240
Query: 241 GDGRIMIGFSCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKI 300
GDGRIMIGFSCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKI
Sbjct: 241 GDGRIMIGFSCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKI 300
Query: 301 QDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTR 360
QDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTR
Sbjct: 301 QDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTR 360
Query: 361 IAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKK 420
IAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKK
Sbjct: 361 IAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKK 420
Query: 421 LKDMEYLGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDKCRILC 480
LKDMEYLGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDKCRILC
Sbjct: 421 LKDMEYLGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDKCRILC 480
Query: 481 HALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFV 540
HALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFV
Sbjct: 481 HALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKSDGFV 540
Query: 541 YCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGAKVILAG 600
YCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGAKVILAG
Sbjct: 541 YCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIAYDDDKVYTYVFHKDTIQGAKVILAG 600
Query: 601 STKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLAQNLMLK 660
STKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLAQNLMLK
Sbjct: 601 STKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLAQNLMLK 660
Query: 661 RFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYN 720
RFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYN
Sbjct: 661 RFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYN 720
Query: 721 LLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKE 780
LLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKE
Sbjct: 721 LLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKE 780
Query: 781 YAIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSR 840
YAIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSR
Sbjct: 781 YAIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSR 840
Query: 841 VLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQ 900
VLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQ
Sbjct: 841 VLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQ 900
Query: 901 YAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARF 960
YAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARF
Sbjct: 901 YAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARF 960
Query: 961 FLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYFEGE 1020
FLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYFEGE
Sbjct: 961 FLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYFEGE 1020
Query: 1021 KRYLQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLG 1080
KRYLQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLG
Sbjct: 1021 KRYLQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQLIDHLLG 1080
Query: 1081 ENDGMPKDAKYLFRLYMALKQYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQK 1140
ENDGMPKDAKYLFRLYMALKQYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQK
Sbjct: 1081 ENDGMPKDAKYLFRLYMALKQYREAAQTAIIIAREEQSAGNYRNAHDVLFSMYAELKSQK 1140
Query: 1141 IKIPSEMATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIE 1200
IKIPSEMATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIE
Sbjct: 1141 IKIPSEMATNLMILHSYILVKIHVKNGDHMKGARMLIRVANNISKFPSHIVPILTSTVIE 1200
Query: 1201 CHRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEATTPCPFCKFLL 1260
CHRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEATTPCPFCKFLL
Sbjct: 1201 CHRAGLKNSAFSFAAMLMRPEYRSKIDAKYKKKIEGMVRRPDISEIEEATTPCPFCKFLL 1260
Query: 1261 PECELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCDFPALYSELKIMLNTESTCPMCSER 1320
PECELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCDFPALYSELKIMLNTESTCPMCSER
Sbjct: 1261 PECELLCPGCKNSIPYCIATGRHMLKDDWTVCPHCDFPALYSELKIMLNTESTCPMCSER 1320
Query: 1321 LNAAQLKKISDCTQYLRTEEEL 1342
LNAAQLKKISDCTQYLRTEEEL
Sbjct: 1321 LNAAQLKKISDCTQYLRTEEEL 1342
>gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]
Length = 496
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/88 (37%), Positives = 55/88 (62%), Gaps = 3/88 (3%)
Query: 77 SCIYLWDANTNKTSQL-DNGMR-DQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPV 134
+C+YLW A T++ ++L D + D ++ + WS+ G+ +AVGT KG + I++ +K+ +
Sbjct: 207 TCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSM 266
Query: 135 LGKHTKRITCGCWNAENLLALGGEDKMI 162
L HT R+ WNAE L+ G D+MI
Sbjct: 267 LEGHTARVGALAWNAEQ-LSSGSRDRMI 293
Score = 33.1 bits (74), Expect = 1.8
Identities = 34/153 (22%), Positives = 56/153 (36%), Gaps = 46/153 (30%)
Query: 50 EINLPGNCV-AMDWDKDGDVLAVIAEKSSCIYLWDANTNK------------------TS 90
++++ G+ V ++ W + G+++AV K + +WDA K
Sbjct: 224 DLSVEGDSVTSVGWSERGNLVAVGTHKGF-VQIWDAAAGKKLSMLEGHTARVGALAWNAE 282
Query: 91 QLDNGMRDQMSF------------------------LLWSKVGSFLAVGTVKGNLLIYNH 126
QL +G RD+M L WS LA G LL++NH
Sbjct: 283 QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 342
Query: 127 QTSRKIPVLGKHTKRITCGCW--NAENLLALGG 157
+ + +H + W + LLA GG
Sbjct: 343 SSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGG 375
>gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
Length = 493
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/88 (37%), Positives = 55/88 (62%), Gaps = 3/88 (3%)
Query: 77 SCIYLWDANTNKTSQL-DNGMR-DQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPV 134
+C+YLW A T++ ++L D + D ++ + WS+ G+ +AVGT KG + I++ +K+ +
Sbjct: 207 TCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSM 266
Query: 135 LGKHTKRITCGCWNAENLLALGGEDKMI 162
L HT R+ WNAE L+ G D+MI
Sbjct: 267 LEGHTARVGALAWNAEQ-LSSGSRDRMI 293
Score = 33.1 bits (74), Expect = 1.8
Identities = 34/153 (22%), Positives = 56/153 (36%), Gaps = 46/153 (30%)
Query: 50 EINLPGNCV-AMDWDKDGDVLAVIAEKSSCIYLWDANTNK------------------TS 90
++++ G+ V ++ W + G+++AV K + +WDA K
Sbjct: 224 DLSVEGDSVTSVGWSERGNLVAVGTHKGF-VQIWDAAAGKKLSMLEGHTARVGALAWNAE 282
Query: 91 QLDNGMRDQMSF------------------------LLWSKVGSFLAVGTVKGNLLIYNH 126
QL +G RD+M L WS LA G LL++NH
Sbjct: 283 QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 342
Query: 127 QTSRKIPVLGKHTKRITCGCW--NAENLLALGG 157
+ + +H + W + LLA GG
Sbjct: 343 SSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGG 375
>gi|41281447 intraflagellar transport 140 [Homo sapiens]
Length = 1462
Score = 57.0 bits (136), Expect = 1e-07
Identities = 111/564 (19%), Positives = 191/564 (33%), Gaps = 90/564 (15%)
Query: 664 DAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIEDYNLLA 723
+A++ +++ EA W +AR C+ ++ A +GN+G ++ E L
Sbjct: 790 EAFKSIKLIKSEAVWENMARMCVKTQRLDVAKVC---LGNMGHARGARALREAEQEPELE 846
Query: 724 GHLAMFTNDYNLAQD---LYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKE 780
+A+ + +D LY + + W ALQ+A+H +
Sbjct: 847 ARVAVLATQLGMLEDAEQLYRKCKRHDLLNKFYQAAGRWQEALQVAEHHDRVHLRSTYHR 906
Query: 781 YAIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSR 840
YA LE + D AL++YEK D +S + + VN K +
Sbjct: 907 YAGHLEASADCSRALSYYEKS--------DTHRFEVPRMLSEDLPSLELYVN---KMKDK 955
Query: 841 VLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQ 900
L R LE+ + A YE + ++ N K + +
Sbjct: 956 TLWRWWAQYLESQGEMDAALHYYELARDHFSLVRIHCFQGNVQKAAQIANETGNLAASYH 1015
Query: 901 YAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDH-----------LNNPE---------- 939
A+ E+ +AV Y A+ +++ IR+ ++ L++PE
Sbjct: 1016 LARQYESQEEVGQAVHFYTRAQAFKNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYE 1075
Query: 940 --------------------KAVNIVRETQSLDGAKMVAR----------------FFLQ 963
KA+ + TQ +++A FF++
Sbjct: 1076 EKGVQMDRAVMLYHKAGHFSKALELAFATQQFVALQLIAEDLDETSDPALLARCSDFFIE 1135
Query: 964 LGDYGSAIQFLVMSKCNNEAFTLAQQHN---------KMEIYADIIG-SEDTTNEDYQSI 1013
Y A++ L+ ++ EA L N KM + D E++ E + I
Sbjct: 1136 HSQYERAVELLLAARKYQEALQLCLGQNMSITEEMAEKMTVAKDSSDLPEESRRELLEQI 1195
Query: 1014 ALYFEGEKRYLQAGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKDELLTNQ 1073
A + Y A K + G +A++ LK S D I Q + ++
Sbjct: 1196 ADCCMRQGSYHLATKKYTQAGNKLKAMRALLK---SGDTEKITFFASVSRQKEIYIMAAN 1252
Query: 1074 LIDHLLGENDGMPKDAKYLFRLYMALKQYREAAQTAIIIAREE-QSAGNYRNAHDVLFSM 1132
+ L + P+ K + Y + A A+ E NY AH L
Sbjct: 1253 YLQSLDWRKE--PEIMKNIIGFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEA 1310
Query: 1133 YAELKSQKIKIPSEMATNLMILHS 1156
Y L K K P + T L L S
Sbjct: 1311 YKCLAKAKAKSPLDQETRLAQLQS 1334
>gi|16554625 WD repeat domain 10 isoform 4 [Homo sapiens]
Length = 1131
Score = 56.6 bits (135), Expect = 2e-07
Identities = 135/686 (19%), Positives = 260/686 (37%), Gaps = 85/686 (12%)
Query: 307 KDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTS 366
KD + + E+N + T D + + Q G++ + + R AY S
Sbjct: 198 KDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDS 257
Query: 367 LLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEY 426
+ +V V + + E + + +A+ LA+ + + Y L + L DM Y
Sbjct: 258 MTDVIVQHLIT-EQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYS---EDLSDMHY 313
Query: 427 LGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDK----------C 476
I FE + + IL ++ + F V ++
Sbjct: 314 RVKEKII--------KKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYI 365
Query: 477 RILCHALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKS 536
+++ + L+ G G + ++++ + + +V+ + + +L +DE
Sbjct: 366 KVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDEND 425
Query: 537 DGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIA--YDDDKVYTYVFHKDTIQGA 594
VY + T E+ P V W D F Y + K T+ H+ +QG
Sbjct: 426 TCLVY---DIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGF 482
Query: 595 KVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLA 654
V GS ++ C H F ++ + PM
Sbjct: 483 VVGYNGS---------------KIFC-------------LHVF--SISAVEVPQSAPMY- 511
Query: 655 QNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVG---IVMSLE 711
Q L K F +A+++ + + W ELA L ++ E A + + R+ ++ ++ S+E
Sbjct: 512 QYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIE 571
Query: 712 QIK--GIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHL 769
+ K G + +L + + ++ A LY S ALEM DL ++ A
Sbjct: 572 ERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSG 631
Query: 770 APDQIPFISKEYAIQLEFAGDYVNALAHYEKGIT-GDNKEHDEACLA-GVAQMSIRMGDI 827
P + + + Q ++A + A E I+ G++ + E C G M I DI
Sbjct: 632 DPKETKMLITK---QADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLI---DI 685
Query: 828 RRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK--- 884
R +++A + P + C L+ + AA+ Y K +++ ++ W +
Sbjct: 686 ARKLDKAEREPLLL----CATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFA 741
Query: 885 VGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNI 944
+G+ P I++ YA+ + R++EA A+ A + + +++ L+ L N N
Sbjct: 742 LGEKHPEFKDD-IYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQV-LEQLTN-----NA 794
Query: 945 VRETQSLDGAKMVARFFLQLGDYGSA 970
V E++ D A +Q D A
Sbjct: 795 VAESRFNDAAYYYWMLSMQCLDIAQA 820
Score = 38.5 bits (88), Expect = 0.044
Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 29/204 (14%)
Query: 855 QFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKE- 913
+F EAA+LY++ + + A +Y + D L + + K + KE
Sbjct: 594 KFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEP 653
Query: 914 --AVVAYENAKQWQSVIRIYLDH------------LNNPEKAVNIVRET--QSLDGAKMV 957
AV Y +A + I I DH L+ E+ ++ T + LD
Sbjct: 654 KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYA 713
Query: 958 ARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYF 1017
A +L++GD S +Q V ++ +EAF L ++H + + ++ Y A +
Sbjct: 714 AETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK------------DDIYMPYAQWL 761
Query: 1018 EGEKRYLQAGKFFLLCGQYSRALK 1041
R+ +A K F G+ A++
Sbjct: 762 AENDRFEEAQKAFHKAGRQREAVQ 785
>gi|16554621 WD repeat domain 10 isoform 1 [Homo sapiens]
Length = 1292
Score = 56.2 bits (134), Expect = 2e-07
Identities = 132/670 (19%), Positives = 256/670 (38%), Gaps = 85/670 (12%)
Query: 307 KDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTS 366
KD + + E+N + T D + + Q G++ + + R AY S
Sbjct: 360 KDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDS 419
Query: 367 LLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEY 426
+ +V V + + E + + +A+ LA+ + + Y L + L DM Y
Sbjct: 420 MTDVIVQHLIT-EQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYS---EDLSDMHY 475
Query: 427 LGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDK----------C 476
I FE + + IL ++ + F V ++
Sbjct: 476 RVKEKII--------KKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYI 527
Query: 477 RILCHALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKS 536
+++ + L+ G G + ++++ + + +V+ + + +L +DE
Sbjct: 528 KVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDEND 587
Query: 537 DGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIA--YDDDKVYTYVFHKDTIQGA 594
VY + T E+ P V W D F Y + K T+ H+ +QG
Sbjct: 588 TCLVY---DIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGF 644
Query: 595 KVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLA 654
V GS ++ C H F ++ + PM
Sbjct: 645 VVGYNGS---------------KIFC-------------LHVF--SISAVEVPQSAPMY- 673
Query: 655 QNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVG---IVMSLE 711
Q L K F +A+++ + + W ELA L ++ E A + + R+ ++ ++ S+E
Sbjct: 674 QYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIE 733
Query: 712 QIK--GIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHL 769
+ K G + +L + + ++ A LY S ALEM DL ++ A
Sbjct: 734 ERKKQGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSG 793
Query: 770 APDQIPFISKEYAIQLEFAGDYVNALAHYEKGIT-GDNKEHDEACLA-GVAQMSIRMGDI 827
P + + + Q ++A + A E I+ G++ + E C G M I DI
Sbjct: 794 DPKETKMLITK---QADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLI---DI 847
Query: 828 RRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK--- 884
R +++A + P + C L+ + AA+ Y K +++ ++ W +
Sbjct: 848 ARKLDKAEREPLLL----CATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFA 903
Query: 885 VGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNI 944
+G+ P I++ YA+ + R++EA A+ A + + +++ L+ L N N
Sbjct: 904 LGEKHPEFKDD-IYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQV-LEQLTN-----NA 956
Query: 945 VRETQSLDGA 954
V E++ D A
Sbjct: 957 VAESRFNDAA 966
Score = 38.5 bits (88), Expect = 0.044
Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 29/204 (14%)
Query: 855 QFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKE- 913
+F EAA+LY++ + + A +Y + D L + + K + KE
Sbjct: 756 KFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEP 815
Query: 914 --AVVAYENAKQWQSVIRIYLDH------------LNNPEKAVNIVRET--QSLDGAKMV 957
AV Y +A + I I DH L+ E+ ++ T + LD
Sbjct: 816 KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYA 875
Query: 958 ARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYF 1017
A +L++GD S +Q V ++ +EAF L ++H + + ++ Y A +
Sbjct: 876 AETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK------------DDIYMPYAQWL 923
Query: 1018 EGEKRYLQAGKFFLLCGQYSRALK 1041
R+ +A K F G+ A++
Sbjct: 924 AENDRFEEAQKAFHKAGRQREAVQ 947
>gi|16554619 WD repeat domain 10 isoform 3 [Homo sapiens]
Length = 1182
Score = 56.2 bits (134), Expect = 2e-07
Identities = 132/670 (19%), Positives = 256/670 (38%), Gaps = 85/670 (12%)
Query: 307 KDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTS 366
KD + + E+N + T D + + Q G++ + + R AY S
Sbjct: 250 KDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDS 309
Query: 367 LLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEY 426
+ +V V + + E + + +A+ LA+ + + Y L + L DM Y
Sbjct: 310 MTDVIVQHLIT-EQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYS---EDLSDMHY 365
Query: 427 LGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDK----------C 476
I FE + + IL ++ + F V ++
Sbjct: 366 RVKEKII--------KKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYI 417
Query: 477 RILCHALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKS 536
+++ + L+ G G + ++++ + + +V+ + + +L +DE
Sbjct: 418 KVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDEND 477
Query: 537 DGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIA--YDDDKVYTYVFHKDTIQGA 594
VY + T E+ P V W D F Y + K T+ H+ +QG
Sbjct: 478 TCLVY---DIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGF 534
Query: 595 KVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLA 654
V GS ++ C H F ++ + PM
Sbjct: 535 VVGYNGS---------------KIFC-------------LHVF--SISAVEVPQSAPMY- 563
Query: 655 QNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVG---IVMSLE 711
Q L K F +A+++ + + W ELA L ++ E A + + R+ ++ ++ S+E
Sbjct: 564 QYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIE 623
Query: 712 QIK--GIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHL 769
+ K G + +L + + ++ A LY S ALEM DL ++ A
Sbjct: 624 ERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSG 683
Query: 770 APDQIPFISKEYAIQLEFAGDYVNALAHYEKGIT-GDNKEHDEACLA-GVAQMSIRMGDI 827
P + + + Q ++A + A E I+ G++ + E C G M I DI
Sbjct: 684 DPKETKMLITK---QADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLI---DI 737
Query: 828 RRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK--- 884
R +++A + P + C L+ + AA+ Y K +++ ++ W +
Sbjct: 738 ARKLDKAEREPLLL----CATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFA 793
Query: 885 VGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNI 944
+G+ P I++ YA+ + R++EA A+ A + + +++ L+ L N N
Sbjct: 794 LGEKHPEFKDD-IYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQV-LEQLTN-----NA 846
Query: 945 VRETQSLDGA 954
V E++ D A
Sbjct: 847 VAESRFNDAA 856
Score = 38.5 bits (88), Expect = 0.044
Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 29/204 (14%)
Query: 855 QFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKE- 913
+F EAA+LY++ + + A +Y + D L + + K + KE
Sbjct: 646 KFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEP 705
Query: 914 --AVVAYENAKQWQSVIRIYLDH------------LNNPEKAVNIVRET--QSLDGAKMV 957
AV Y +A + I I DH L+ E+ ++ T + LD
Sbjct: 706 KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYA 765
Query: 958 ARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYF 1017
A +L++GD S +Q V ++ +EAF L ++H + + ++ Y A +
Sbjct: 766 AETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK------------DDIYMPYAQWL 813
Query: 1018 EGEKRYLQAGKFFLLCGQYSRALK 1041
R+ +A K F G+ A++
Sbjct: 814 AENDRFEEAQKAFHKAGRQREAVQ 837
>gi|16554623 WD repeat domain 10 isoform 2 [Homo sapiens]
Length = 1241
Score = 56.2 bits (134), Expect = 2e-07
Identities = 132/670 (19%), Positives = 256/670 (38%), Gaps = 85/670 (12%)
Query: 307 KDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTS 366
KD + + E+N + T D + + Q G++ + + R AY S
Sbjct: 309 KDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDS 368
Query: 367 LLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKLKDMEY 426
+ +V V + + E + + +A+ LA+ + + Y L + L DM Y
Sbjct: 369 MTDVIVQHLIT-EQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYS---EDLSDMHY 424
Query: 427 LGTVASICLHSDYAAALFEGKVQLHLIESEILDAQEERETRLFPAVDDK----------C 476
I FE + + IL ++ + F V ++
Sbjct: 425 RVKEKII--------KKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYI 476
Query: 477 RILCHALTSDFLIYGTDTGVVQYFYIEDWQFVNDYRHPVSVKKIFPDPNGTRLVFIDEKS 536
+++ + L+ G G + ++++ + + +V+ + + +L +DE
Sbjct: 477 KVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDEND 536
Query: 537 DGFVYCPVNDATYEIPDFSPTIKGVLWENWPMDKGVFIA--YDDDKVYTYVFHKDTIQGA 594
VY + T E+ P V W D F Y + K T+ H+ +QG
Sbjct: 537 TCLVY---DIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGF 593
Query: 595 KVILAGSTKVPFAHKPLLLYNGELTCQTQSGKVNNIYLSTHGFLSNLKDTGPDELRPMLA 654
V GS ++ C H F ++ + PM
Sbjct: 594 VVGYNGS---------------KIFC-------------LHVF--SISAVEVPQSAPMY- 622
Query: 655 QNLMLKRFSDAWEMCRILNDEAAWNELARACLHHMEVEFAIRVYRRIGNVG---IVMSLE 711
Q L K F +A+++ + + W ELA L ++ E A + + R+ ++ ++ S+E
Sbjct: 623 QYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIE 682
Query: 712 QIK--GIEDYNLLAGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHL 769
+ K G + +L + + ++ A LY S ALEM DL ++ A
Sbjct: 683 ERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSG 742
Query: 770 APDQIPFISKEYAIQLEFAGDYVNALAHYEKGIT-GDNKEHDEACLA-GVAQMSIRMGDI 827
P + + + Q ++A + A E I+ G++ + E C G M I DI
Sbjct: 743 DPKETKMLITK---QADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLI---DI 796
Query: 828 RRGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK--- 884
R +++A + P + C L+ + AA+ Y K +++ ++ W +
Sbjct: 797 ARKLDKAEREPLLL----CATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFA 852
Query: 885 VGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNI 944
+G+ P I++ YA+ + R++EA A+ A + + +++ L+ L N N
Sbjct: 853 LGEKHPEFKDD-IYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQV-LEQLTN-----NA 905
Query: 945 VRETQSLDGA 954
V E++ D A
Sbjct: 906 VAESRFNDAA 915
Score = 38.5 bits (88), Expect = 0.044
Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 29/204 (14%)
Query: 855 QFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKE- 913
+F EAA+LY++ + + A +Y + D L + + K + KE
Sbjct: 705 KFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEP 764
Query: 914 --AVVAYENAKQWQSVIRIYLDH------------LNNPEKAVNIVRET--QSLDGAKMV 957
AV Y +A + I I DH L+ E+ ++ T + LD
Sbjct: 765 KAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYA 824
Query: 958 ARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSEDTTNEDYQSIALYF 1017
A +L++GD S +Q V ++ +EAF L ++H + + ++ Y A +
Sbjct: 825 AETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFK------------DDIYMPYAQWL 872
Query: 1018 EGEKRYLQAGKFFLLCGQYSRALK 1041
R+ +A K F G+ A++
Sbjct: 873 AENDRFEEAQKAFHKAGRQREAVQ 896
>gi|46358428 selective LIM binding factor homolog [Homo sapiens]
Length = 1749
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/388 (22%), Positives = 150/388 (38%), Gaps = 47/388 (12%)
Query: 740 YLASSCPIAALEMRRDLQHWDSALQLA----KHLAPDQIPFISKEYAIQLEFAGDYVNAL 795
Y+ + C I A+E + W A+ + ++ A P +++ YA E Y A
Sbjct: 877 YIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLVAQHYASLQE----YEIAE 932
Query: 796 AHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALK----HPSRVLKRDCGAILE 851
Y KG ++ D M + G + A+K VL +E
Sbjct: 933 ELYTKG----DRTKD------AIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEME 982
Query: 852 NMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK----VGDLLPHVSSPKIHLQYAKAKEA 907
++ EA +LY D A ++Y + K + VG P + S HL K EA
Sbjct: 983 KQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDT-HLHLGKELEA 1041
Query: 908 DGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDY 967
+GR +EA Y A++W++ + +Y E+A + R + K VA + +
Sbjct: 1042 EGRLQEAEYHYLEAQEWKATVNMYRAS-GLWEEAYRVARTQGGANAHKHVAYLWAKSLGG 1100
Query: 968 GSAIQFLVMSKCNNEAFTLAQQHNKMEIYADI--IGSEDTTNEDYQSIALYFEGEKRYLQ 1025
+A++ L A A + E ++ + + T E + A++ E E ++ +
Sbjct: 1101 EAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKHKTPEVHLKYAMFLEDEGKFEE 1160
Query: 1026 AGKFFLLCGQYSRALKHFLKCPSSEDNVAIEMAIETVGQAKD-----ELLTNQLIDHLLG 1080
A F+ G+ A+ F+ E A + V +A D E+L Q L
Sbjct: 1161 AEAEFIRAGKPKEAVLMFVHNQDWE-------AAQRVAEAHDPDSVAEVLVGQARGAL-- 1211
Query: 1081 ENDGMPKDAKYLFRLY---MALKQYREA 1105
E K L R +AL Y+EA
Sbjct: 1212 EEKDFQKAEGLLLRAQRPGLALNYYKEA 1239
Score = 47.4 bits (111), Expect = 9e-05
Identities = 50/207 (24%), Positives = 77/207 (37%), Gaps = 42/207 (20%)
Query: 727 AMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEY----- 781
A+ D+ A+ L L + P AL ++ W AL++ K P Q+ + +EY
Sbjct: 1210 ALEEKDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREAT 1269
Query: 782 -------------AIQLEFAGDYVNALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIR 828
A E AG+Y A+ Y K N E C A++SI+ +
Sbjct: 1270 KKGARGVEGFVEQARHWEQAGEYSRAVDCYLKVRDSGNSGLAEKCWMKAAELSIKFLPPQ 1329
Query: 829 RGVNQALKHPSRVLKRDCGAILENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDL 888
R + L G L + + S AA+LY +A +I + W K +
Sbjct: 1330 RNMEVVLA---------VGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRV 1380
Query: 889 LPHVSSPKIHLQYAKAKEADGRYKEAV 915
AKE D RY++ V
Sbjct: 1381 ---------------AKELDPRYEDYV 1392
Score = 47.0 bits (110), Expect = 1e-04
Identities = 82/440 (18%), Positives = 156/440 (35%), Gaps = 94/440 (21%)
Query: 675 EAAWNELARACLHHMEVEFAIRVYRRIGNVGIVMSLEQIKGIED------------YNLL 722
EA W L++ L ++ A R + +G V L + I D + +
Sbjct: 625 EAMWKTLSKLALEARQLHIAERCFSALGQVAKARFLHETNEIADQVSREYGGEGTDFYQV 684
Query: 723 AGHLAMFTNDYNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEYA 782
LAM +Y LA+ ++L + A+ M ++L WD + +A+ + + + Y
Sbjct: 685 RARLAMLEKNYKLAEMIFLEQNAVEEAMGMYQELHRWDECIAVAEAKGHPALEKLRRSYY 744
Query: 783 IQL-------------EFAGDYVNALAHYEKG-----------------ITGDNKEHDEA 812
L E GD + A++ Y K + EH A
Sbjct: 745 QWLMDTQQEERAGELQESQGDGLAAISLYLKAGLPAKAARLVLTREELLANTELVEHITA 804
Query: 813 CLAGVAQMSIRMGDIRRGVNQ---------------------ALKHPSRVLKRD--CGAI 849
L ++ R GD+ ++ L P V+K + G
Sbjct: 805 ALI-KGELYERAGDLFEKIHNPQKALECYRKGNAFMKAVELARLAFPVEVVKLEEAWGDH 863
Query: 850 LENMKQFSEAAQLYEKGLYYDKAASVYIRSKNWAK---VGDLLPHVSS----PKIHLQYA 902
L KQ A Y + KA + ++ W K + DL ++ P + YA
Sbjct: 864 LVQQKQLDAAINHYIEARCSIKAIEAALGARQWKKAIYILDLQDRNTASKYYPLVAQHYA 923
Query: 903 KAKEAD---------GRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDG 953
+E + R K+A+ Y A +W+ ++ + + + +V + + Q ++
Sbjct: 924 SLQEYEIAEELYTKGDRTKDAIDMYTQAGRWEQAHKLAMKCMRPEDVSVLYITQAQEME- 982
Query: 954 AKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKMEIYADIIGSE--DTTNEDYQ 1011
+ G Y A + V + + A T+ ++H + ++G D ++ +
Sbjct: 983 ---------KQGKYREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHL 1033
Query: 1012 SIALYFEGEKRYLQAGKFFL 1031
+ E E R +A +L
Sbjct: 1034 HLGKELEAEGRLQEAEYHYL 1053
Score = 41.2 bits (95), Expect = 0.007
Identities = 70/332 (21%), Positives = 136/332 (40%), Gaps = 28/332 (8%)
Query: 733 YNLAQDLYLASSCPIAALEMRRDLQHWDSALQLAKHLAPDQIPFISKEYAIQLEFAGDYV 792
Y A+ LY+ P A+ M + + +D ++L PD + +LE G
Sbjct: 987 YREAERLYVTVQEPDLAITMYKKHKLYDDMIRLVGKHHPDLLSDTHLHLGKELEAEGRLQ 1046
Query: 793 NALAHYEKGITGDNKEHDEACLAGVAQMSIRMGDIRRGVNQALKHPSRVLKRDCGAILEN 852
A HY + + +G+ + + R+ + G N A KH + + + G
Sbjct: 1047 EAEYHYLEAQEWKATVNMYRA-SGLWEEAYRVARTQGGAN-AHKHVAYLWAKSLGG---- 1100
Query: 853 MKQFSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDL----LPHVSSPKIHLQYAKAKEAD 908
A +L K + A + ++ +L L H +P++HL+YA E +
Sbjct: 1101 ----EAAVRLLNKLGLLEAAVDHAADNCSFEFAFELSRLALKH-KTPEVHLKYAMFLEDE 1155
Query: 909 GRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMV----ARFFLQL 964
G+++EA + A + + + +++ N +A V E D V AR L+
Sbjct: 1156 GKFEEAEAEFIRAGKPKEAVLMFVH--NQDWEAAQRVAEAHDPDSVAEVLVGQARGALEE 1213
Query: 965 GDYGSAIQFLVMSKCNNEAFTLAQQ----HNKMEIYADIIGSE-DTTNEDYQSIALY--F 1017
D+ A L+ ++ A ++ + + I D + S+ + E+Y+ A
Sbjct: 1214 KDFQKAEGLLLRAQRPGLALNYYKEAGLWSDALRICKDYVPSQLEALQEEYEREATKKGA 1273
Query: 1018 EGEKRYLQAGKFFLLCGQYSRALKHFLKCPSS 1049
G + +++ + + G+YSRA+ +LK S
Sbjct: 1274 RGVEGFVEQARHWEQAGEYSRAVDCYLKVRDS 1305
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 48.5 bits (114), Expect = 4e-05
Identities = 28/92 (30%), Positives = 51/92 (55%), Gaps = 5/92 (5%)
Query: 60 MDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMR--DQMSFLLWSKVGSFLAVGTV 117
+DW G+VLAV + S +YLW A++ QL + + +S + W K G++LAVGT
Sbjct: 190 VDWSS-GNVLAVALDNS--VYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTS 246
Query: 118 KGNLLIYNHQTSRKIPVLGKHTKRITCGCWNA 149
+ +++ Q +++ + H+ R+ WN+
Sbjct: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS 278
>gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
Length = 404
Score = 48.5 bits (114), Expect = 4e-05
Identities = 25/65 (38%), Positives = 40/65 (61%), Gaps = 1/65 (1%)
Query: 98 DQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGG 157
D ++ + WS+ G+ +AVGT KG + I++ +K+ +L HT R+ WNAE L+ G
Sbjct: 141 DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ-LSSGS 199
Query: 158 EDKMI 162
D+MI
Sbjct: 200 RDRMI 204
Score = 33.1 bits (74), Expect = 1.8
Identities = 34/153 (22%), Positives = 56/153 (36%), Gaps = 46/153 (30%)
Query: 50 EINLPGNCV-AMDWDKDGDVLAVIAEKSSCIYLWDANTNK------------------TS 90
++++ G+ V ++ W + G+++AV K + +WDA K
Sbjct: 135 DLSVEGDSVTSVGWSERGNLVAVGTHKGF-VQIWDAAAGKKLSMLEGHTARVGALAWNAE 193
Query: 91 QLDNGMRDQMSF------------------------LLWSKVGSFLAVGTVKGNLLIYNH 126
QL +G RD+M L WS LA G LL++NH
Sbjct: 194 QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNH 253
Query: 127 QTSRKIPVLGKHTKRITCGCW--NAENLLALGG 157
+ + +H + W + LLA GG
Sbjct: 254 SSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGG 286
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 45.4 bits (106), Expect = 4e-04
Identities = 80/367 (21%), Positives = 142/367 (38%), Gaps = 56/367 (15%)
Query: 15 APIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGN---CVAMDWDKDGDVLAV 71
A I A+ T G YLA D V+ +D + G+ +++ W DG LA
Sbjct: 116 AVISVAFSPT-GKYLASGSGDTTVRFWDL-STETPHFTCKGHRHWVLSISWSPDGRKLAS 173
Query: 72 IAEKSSCIYLWDANTNK-TSQLDNGMRDQMSFLLWSKVGS-----FLAVGTVKGNLLIYN 125
K+ I LWD +T K + G ++ L W + + ++A + G++ I++
Sbjct: 174 GC-KNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 126 HQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDKMITVSNQEGDTIRQT---------- 175
R +L HT+ +TC W + LL +D+ I V + +T
Sbjct: 233 TTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNT 292
Query: 176 -----------------QVRSEPSNMQFFLMKMDDRTSAAESMI------SVVLGKK--T 210
+ P ++Q L ++ +R + +++ +V G T
Sbjct: 293 MALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFT 352
Query: 211 LFFLNLNEPDNP-ADLEFQQDFGNIVCYNWYGDGRIMIGFSCGHFVVISTHTGELGQEIF 269
LF + E P + Q N V ++ D RI+ S I G G+ +
Sbjct: 353 LFLWSPAEDKKPLTRMTGHQALINQVLFS--PDSRIVA--SASFDKSIKLWDGRTGKYLA 408
Query: 270 QARNHKDNLTSIAVS-QTLNKVATCGDNCIKIQDLVDLKDMYVILNLDEENKGLGTLSWT 328
R H + IA S + V+ D+ +K+ D+K + ++L + + W+
Sbjct: 409 SLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW---DVKAQKLAMDLPGHADEVYAVDWS 465
Query: 329 DDGQLLA 335
DGQ +A
Sbjct: 466 PDGQRVA 472
>gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform 2
[Homo sapiens]
Length = 1006
Score = 44.3 bits (103), Expect = 8e-04
Identities = 22/78 (28%), Positives = 42/78 (53%)
Query: 51 INLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGS 110
IN C K G +LA+ EKS +Y ++ +++ DN + ++ + WS G
Sbjct: 61 INAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQ 120
Query: 111 FLAVGTVKGNLLIYNHQT 128
+LA G++ G ++++N +T
Sbjct: 121 YLAAGSINGLIIVWNVET 138
>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
[Homo sapiens]
Length = 1129
Score = 44.3 bits (103), Expect = 8e-04
Identities = 22/78 (28%), Positives = 42/78 (53%)
Query: 51 INLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGS 110
IN C K G +LA+ EKS +Y ++ +++ DN + ++ + WS G
Sbjct: 184 INAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQ 243
Query: 111 FLAVGTVKGNLLIYNHQT 128
+LA G++ G ++++N +T
Sbjct: 244 YLAAGSINGLIIVWNVET 261
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 40.4 bits (93), Expect = 0.012
Identities = 58/296 (19%), Positives = 115/296 (38%), Gaps = 47/296 (15%)
Query: 789 GDYVNALAHYEKGITGDNKEHDEAC----LAGVAQMSIRMGDIRRGVNQALKHPSRVLKR 844
GDY NALA +++ + + DE L + + I MGD V +H + +
Sbjct: 328 GDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLK--IAK 385
Query: 845 DCGAILENMKQFSEAAQLYEKGLYYDKAASVY--------------IRSKNWAKVGDLLP 890
D G E + +S Y +DKA S + I + +A +G
Sbjct: 386 DLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAAR 445
Query: 891 HVSSPKIHLQY----------AKAKEADGRYKEAV-VAYENAKQWQSVIRIYLDHLNNPE 939
+ + QY K + A+GR + + ++ + + ++++ HL +
Sbjct: 446 CMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQ 505
Query: 940 KAVNIVRETQSLDGAKMVARFFLQLGDYGSAIQF----LVMSKCNNEAFTLAQQHNKMEI 995
+ + + ++ + + LG Y A+++ L +S N+ + A H + +
Sbjct: 506 ELSDYAAQGRAYGN---MGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAV 562
Query: 996 YADIIGSEDTTNEDYQSIALYFEGEKRYLQA--------GKFFLLCGQYSRALKHF 1043
+G+ D + YQ+ L E R +Q+ G F G+Y +A ++
Sbjct: 563 AYQALGAHDRALQHYQN-HLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYY 617
>gi|44917606 N-ethylmaleimide-sensitive factor attachment protein,
beta [Homo sapiens]
Length = 298
Score = 38.1 bits (87), Expect = 0.057
Identities = 53/262 (20%), Positives = 99/262 (37%), Gaps = 49/262 (18%)
Query: 869 YDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVI 928
Y +AA+++ +KNW+ G+ + K+H+Q ++ + +A AY+ A
Sbjct: 45 YTRAANMFKMAKNWSAAGNAF--CQAAKLHMQLQSKHDSATSFVDAGNAYKKA------- 95
Query: 929 RIYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQ 988
+P++A+N + + + +G FT+A
Sbjct: 96 --------DPQEAINCLNAAIDI---------YTDMG-----------------RFTIAA 121
Query: 989 QHN--KMEIYADIIGSEDTTNEDYQSIALYFEGEKRYLQAGKFFLLCGQYSRALKHFLKC 1046
+H+ EIY + + Y+ A Y++GE+ A K L Y+ L+ + K
Sbjct: 122 KHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKA 181
Query: 1047 PSSEDNVAIEMAIETV--GQAKDELLTNQLIDHLLGENDGMPKDAKYLFRLYMALKQYRE 1104
+ V + AKD L ++ E + KY ++ A RE
Sbjct: 182 IEIYEQVGANTMDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKY-EEMFPAFTDSRE 240
Query: 1105 A-AQTAIIIAREEQSAGNYRNA 1125
++ A EEQ++ Y A
Sbjct: 241 CKLLKKLLEAHEEQNSEAYTEA 262
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 37.4 bits (85), Expect = 0.098
Identities = 59/237 (24%), Positives = 94/237 (39%), Gaps = 57/237 (24%)
Query: 98 DQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN---LLA 154
D++ +S F+A +V + I+N T + +H++++ C + + LLA
Sbjct: 658 DEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLA 717
Query: 155 LGGED---KMITVSNQE------GDTIRQTQVRSEPSNMQFF------LMKMDDRTSAAE 199
G D K+ ++ +E G T R P + +K+ D TSA E
Sbjct: 718 TGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777
Query: 200 -SMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIV-CYNWYGDGRIMIGFSCGHFVVI 257
I+V FFLNL +P Q+D IV C +W DG ++ + +
Sbjct: 778 RKSINV-----KQFFLNLEDP--------QEDMEVIVKCCSWSADGARIMVAAKNKIFLF 824
Query: 258 STHTGELGQEI------------FQARNHKDNLTSIAVSQ---------TLNKVATC 293
HT L EI F +NH L +A+SQ + +KVA C
Sbjct: 825 DIHTSGLLGEIHTGHHSTIQYCDFSPQNH---LAVVALSQYCVELWNTDSRSKVADC 878
Score = 32.3 bits (72), Expect = 3.1
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 250 SCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCG-DNCIKIQDLVDLKD 308
SCG + E G+++ + + H+D + A S +ATC D +KI + + +
Sbjct: 632 SCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE- 690
Query: 309 MYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFL 347
++ DE ++ + +T+ L L+T GS FL
Sbjct: 691 --LVHTYDEHSEQVNCCHFTNSSHHLLLAT--GSSDCFL 725
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 37.4 bits (85), Expect = 0.098
Identities = 59/237 (24%), Positives = 94/237 (39%), Gaps = 57/237 (24%)
Query: 98 DQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN---LLA 154
D++ +S F+A +V + I+N T + +H++++ C + + LLA
Sbjct: 647 DEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLA 706
Query: 155 LGGED---KMITVSNQE------GDTIRQTQVRSEPSNMQFF------LMKMDDRTSAAE 199
G D K+ ++ +E G T R P + +K+ D TSA E
Sbjct: 707 TGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
Query: 200 -SMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIV-CYNWYGDGRIMIGFSCGHFVVI 257
I+V FFLNL +P Q+D IV C +W DG ++ + +
Sbjct: 767 RKSINV-----KQFFLNLEDP--------QEDMEVIVKCCSWSADGARIMVAAKNKIFLF 813
Query: 258 STHTGELGQEI------------FQARNHKDNLTSIAVSQ---------TLNKVATC 293
HT L EI F +NH L +A+SQ + +KVA C
Sbjct: 814 DIHTSGLLGEIHTGHHSTIQYCDFSPQNH---LAVVALSQYCVELWNTDSRSKVADC 867
Score = 32.3 bits (72), Expect = 3.1
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 250 SCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCG-DNCIKIQDLVDLKD 308
SCG + E G+++ + + H+D + A S +ATC D +KI + + +
Sbjct: 621 SCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE- 679
Query: 309 MYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFL 347
++ DE ++ + +T+ L L+T GS FL
Sbjct: 680 --LVHTYDEHSEQVNCCHFTNSSHHLLLAT--GSSDCFL 714
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 37.0 bits (84), Expect = 0.13
Identities = 38/155 (24%), Positives = 67/155 (43%), Gaps = 8/155 (5%)
Query: 16 PIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGNCVAMD---WDKDGDVLAVI 72
P++F G+ A D V+++D K + L G+ +++ + D LA
Sbjct: 65 PVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRV-LKGHQRSVETVSFSPDSRQLAS- 122
Query: 73 AEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKI 132
+ LWD + + +L G RD + +S + LA G+ + I++ +
Sbjct: 123 GGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPA 182
Query: 133 ---PVLGKHTKRITCGCWNAENLLALGGEDKMITV 164
L H+ I+C C++A LLA G DK I +
Sbjct: 183 VSHQALEGHSANISCLCYSASGLLASGSWDKTIHI 217
Score = 32.7 bits (73), Expect = 2.4
Identities = 31/138 (22%), Positives = 61/138 (44%), Gaps = 12/138 (8%)
Query: 38 VKIFDRHGQKRSEINLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMR 97
VK F +HG E+N + + DG +L +E C+Y W+ + + G
Sbjct: 14 VKFFGQHG---GEVN------SSAFSPDGQMLLTGSE-DGCVYGWETRSGQLLWRLGGHT 63
Query: 98 DQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN-LLALG 156
+ F +S G A + + +++ ++ + VL H + + ++ ++ LA G
Sbjct: 64 GPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123
Query: 157 GEDKMITVSN-QEGDTIR 173
G DK + + + Q G +R
Sbjct: 124 GWDKRVMLWDVQSGQMLR 141
>gi|22749275 CDC20 cell division cycle 20 homolog B isoform 1 [Homo
sapiens]
Length = 515
Score = 37.0 bits (84), Expect = 0.13
Identities = 23/91 (25%), Positives = 44/91 (48%), Gaps = 5/91 (5%)
Query: 60 MDWDKDGDVLAVIAEKSSCIYLWDA-NTNKTSQLDNGMR-DQMSFLLWSKVGSFLAVGTV 117
+DW V + S +Y+W+ N N +D + + +S + W K G+ LAVGT
Sbjct: 237 LDWSFQNLVAIALG---SAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTS 293
Query: 118 KGNLLIYNHQTSRKIPVLGKHTKRITCGCWN 148
+G + +++ T +++ + H + WN
Sbjct: 294 EGEVQLWDVVTKKRLRNMLGHLSVVGALSWN 324
>gi|224593764 CDC20 cell division cycle 20 homolog B isoform 2 [Homo
sapiens]
Length = 477
Score = 37.0 bits (84), Expect = 0.13
Identities = 23/91 (25%), Positives = 44/91 (48%), Gaps = 5/91 (5%)
Query: 60 MDWDKDGDVLAVIAEKSSCIYLWDA-NTNKTSQLDNGMR-DQMSFLLWSKVGSFLAVGTV 117
+DW V + S +Y+W+ N N +D + + +S + W K G+ LAVGT
Sbjct: 237 LDWSFQNLVAIALG---SAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTS 293
Query: 118 KGNLLIYNHQTSRKIPVLGKHTKRITCGCWN 148
+G + +++ T +++ + H + WN
Sbjct: 294 EGEVQLWDVVTKKRLRNMLGHLSVVGALSWN 324
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 37.0 bits (84), Expect = 0.13
Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 7/105 (6%)
Query: 51 INLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGS 110
++ PG+C D+ G V+A I S ++ DA T + +Q+S + +S G+
Sbjct: 574 VDEPGHCA--DFHPSGTVVA-IGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGT 630
Query: 111 FLAVGTVKGNLLIY-NHQTSRKIPVLGK---HTKRITCGCWNAEN 151
FLAVG+ + +Y + RK G+ H+ IT W+ +N
Sbjct: 631 FLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDN 675
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 37.0 bits (84), Expect = 0.13
Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 7/105 (6%)
Query: 51 INLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGS 110
++ PG+C D+ G V+A I S ++ DA T + +Q+S + +S G+
Sbjct: 632 VDEPGHCA--DFHPSGTVVA-IGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGT 688
Query: 111 FLAVGTVKGNLLIY-NHQTSRKIPVLGK---HTKRITCGCWNAEN 151
FLAVG+ + +Y + RK G+ H+ IT W+ +N
Sbjct: 689 FLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDN 733
>gi|47933379 N-ethylmaleimide-sensitive factor attachment protein,
alpha [Homo sapiens]
Length = 295
Score = 35.8 bits (81), Expect = 0.28
Identities = 54/272 (19%), Positives = 101/272 (37%), Gaps = 49/272 (18%)
Query: 856 FSEAAQLYEKGLYYDKAASVYIRSKNWAKVGDLLPHVSSPKIHLQYAKAKEADGRYKEAV 915
F ++++ E Y +AA+++ +KNW+ G+ + ++HLQ +A + +A
Sbjct: 32 FGGSSKIEEACEIYARAANMFKMAKNWSAAGNAF--CQAAQLHLQLQSKHDAATCFVDAG 89
Query: 916 VAYENAKQWQSVIRIYLDHLNNPEKAVNIVRETQSLDGAKMVARFFLQLGDYGSAIQFLV 975
A++ A +P++A+N + + +G
Sbjct: 90 NAFKKA---------------DPQEAINCLMR---------AIEIYTDMG---------- 115
Query: 976 MSKCNNEAFTLAQQH--NKMEIYADIIGSEDTTNEDYQSIALYFEGEKRYLQAGKFFLLC 1033
FT+A +H + EIY + + Y+ A Y++GE+ A K L
Sbjct: 116 -------RFTIAAKHHISIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKV 168
Query: 1034 GQYSRALKHFLKCPSSEDNVAIEMAIETV--GQAKDELLTNQLIDHLLGENDGMPKDAKY 1091
Y+ L+ + K + V + AKD L + + KY
Sbjct: 169 AGYAALLEQYQKAIDIYEQVGTNAMDSPLLKYSAKDYFFKAALCHFCIDMLNAKLAVQKY 228
Query: 1092 LFRLYMALKQYREA-AQTAIIIAREEQSAGNY 1122
L+ A RE ++ A EEQ+ +Y
Sbjct: 229 -EELFPAFSDSRECKLMKKLLEAHEEQNVDSY 259
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 35.8 bits (81), Expect = 0.28
Identities = 26/84 (30%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 105 WSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN--LLALGGEDKMI 162
+S G L G+V ++++Y+ T + L +HT+ +T C A N LLA G DK +
Sbjct: 247 FSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTT-CAFAPNTLLLATGSMDKTV 305
Query: 163 TVSNQEGDTIRQTQVRSEPSNMQF 186
+ + +T+ Q + R+E QF
Sbjct: 306 NIWQFDLETLCQAR-RTEHQLKQF 328
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 35.8 bits (81), Expect = 0.28
Identities = 26/84 (30%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 105 WSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN--LLALGGEDKMI 162
+S G L G+V ++++Y+ T + L +HT+ +T C A N LLA G DK +
Sbjct: 247 FSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTT-CAFAPNTLLLATGSMDKTV 305
Query: 163 TVSNQEGDTIRQTQVRSEPSNMQF 186
+ + +T+ Q + R+E QF
Sbjct: 306 NIWQFDLETLCQAR-RTEHQLKQF 328
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 35.8 bits (81), Expect = 0.28
Identities = 26/84 (30%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 105 WSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN--LLALGGEDKMI 162
+S G L G+V ++++Y+ T + L +HT+ +T C A N LLA G DK +
Sbjct: 247 FSHDGQMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTT-CAFAPNTLLLATGSMDKTV 305
Query: 163 TVSNQEGDTIRQTQVRSEPSNMQF 186
+ + +T+ Q + R+E QF
Sbjct: 306 NIWQFDLETLCQAR-RTEHQLKQF 328
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 35.4 bits (80), Expect = 0.37
Identities = 46/171 (26%), Positives = 73/171 (42%), Gaps = 34/171 (19%)
Query: 98 DQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN---LLA 154
D++ +S F+A +V + I+N T + +H++++ C + + LLA
Sbjct: 658 DEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLA 717
Query: 155 LGGED---KMITVSNQE------GDTIRQTQVRSEPSNMQFF------LMKMDDRTSAAE 199
G D K+ ++ +E G T R P + +K+ D TSA E
Sbjct: 718 TGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777
Query: 200 -SMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIV-CYNWYGDG-RIMI 247
I+V FFLNL +P Q+D IV C +W DG RIM+
Sbjct: 778 RKSINV-----KQFFLNLEDP--------QEDMEVIVKCCSWSADGARIMV 815
Score = 32.3 bits (72), Expect = 3.1
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 250 SCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCG-DNCIKIQDLVDLKD 308
SCG + E G+++ + + H+D + A S +ATC D +KI + + +
Sbjct: 632 SCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE- 690
Query: 309 MYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFL 347
++ DE ++ + +T+ L L+T GS FL
Sbjct: 691 --LVHTYDEHSEQVNCCHFTNSSHHLLLAT--GSSDCFL 725
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 35.4 bits (80), Expect = 0.37
Identities = 46/171 (26%), Positives = 73/171 (42%), Gaps = 34/171 (19%)
Query: 98 DQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAEN---LLA 154
D++ +S F+A +V + I+N T + +H++++ C + + LLA
Sbjct: 647 DEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLA 706
Query: 155 LGGED---KMITVSNQE------GDTIRQTQVRSEPSNMQFF------LMKMDDRTSAAE 199
G D K+ ++ +E G T R P + +K+ D TSA E
Sbjct: 707 TGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
Query: 200 -SMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIV-CYNWYGDG-RIMI 247
I+V FFLNL +P Q+D IV C +W DG RIM+
Sbjct: 767 RKSINV-----KQFFLNLEDP--------QEDMEVIVKCCSWSADGARIMV 804
Score = 32.3 bits (72), Expect = 3.1
Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 250 SCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCG-DNCIKIQDLVDLKD 308
SCG + E G+++ + + H+D + A S +ATC D +KI + + +
Sbjct: 621 SCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE- 679
Query: 309 MYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFL 347
++ DE ++ + +T+ L L+T GS FL
Sbjct: 680 --LVHTYDEHSEQVNCCHFTNSSHHLLLAT--GSSDCFL 714
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 35.4 bits (80), Expect = 0.37
Identities = 43/166 (25%), Positives = 65/166 (39%), Gaps = 30/166 (18%)
Query: 889 LPHVSSPKIHLQYAKAKEADGRYKEAVVAYENAKQWQSVIRIYLDHLNNPEKAVNIVRET 948
LPH + K+H YA + GR KEA+ Y A +++Y H + + R+T
Sbjct: 371 LPH--NAKVHYNYANFLKDQGRNKEAIYHYRTA------LKLYPRHASALNNLGTLTRDT 422
Query: 949 QSLDGAKMVARFFLQLGDYGSAIQFLVMSKCNNEAFTLAQQHNKME---IYADIIGSEDT 1005
AKM + LQL + F N L Q K E + D I
Sbjct: 423 AE---AKMYYQRALQLHPQHNRALF-------NLGNLLKSQEKKEEAITLLKDSIKYGPE 472
Query: 1006 TNEDYQSIALYFEGEKRYLQAGKFFLLCGQYSRALKHFLKCPSSED 1051
+ Y S+A ++R+ +A + Y +K+ CP S D
Sbjct: 473 FADAYSSLASLLAEQERFKEAEEI------YQTGIKN---CPDSSD 509
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,014,918
Number of Sequences: 37866
Number of extensions: 2065113
Number of successful extensions: 4710
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 4543
Number of HSP's gapped (non-prelim): 211
length of query: 1342
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1228
effective length of database: 13,930,794
effective search space: 17107015032
effective search space used: 17107015032
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.