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Search of human proteins with 55742857
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
(722 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 1429 0.0
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 139 7e-33
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 139 7e-33
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 139 7e-33
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 138 2e-32
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 137 3e-32
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 137 3e-32
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 137 3e-32
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 137 3e-32
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 137 3e-32
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 133 5e-31
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 129 1e-29
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 129 1e-29
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 127 3e-29
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 123 5e-28
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 122 9e-28
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 120 4e-27
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 119 1e-26
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 118 2e-26
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 118 2e-26
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 118 2e-26
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 117 3e-26
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 117 4e-26
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 117 4e-26
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 115 1e-25
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 113 7e-25
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 113 7e-25
gi|30348954 mindbomb homolog 1 [Homo sapiens] 112 1e-24
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 112 1e-24
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 112 1e-24
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 1429 bits (3700), Expect = 0.0
Identities = 722/722 (100%), Positives = 722/722 (100%)
Query: 1 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 60
MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI
Sbjct: 1 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 60
Query: 61 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 120
LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF
Sbjct: 61 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 120
Query: 121 SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 180
SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV
Sbjct: 121 SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 180
Query: 181 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 240
AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG
Sbjct: 181 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 240
Query: 241 QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 300
QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG
Sbjct: 241 QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 300
Query: 301 SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG 360
SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG
Sbjct: 301 SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG 360
Query: 361 HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK 420
HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK
Sbjct: 361 HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK 420
Query: 421 LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL 480
LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL
Sbjct: 421 LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL 480
Query: 481 QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCVDQLVVT 540
QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCVDQLVVT
Sbjct: 481 QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCVDQLVVT 540
Query: 541 AGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAAR 600
AGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAAR
Sbjct: 541 AGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAAR 600
Query: 601 SDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQAL 660
SDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQAL
Sbjct: 601 SDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQAL 660
Query: 661 ELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQK 720
ELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQK
Sbjct: 661 ELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQK 720
Query: 721 EN 722
EN
Sbjct: 721 EN 722
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 139 bits (351), Expect = 7e-33
Identities = 88/247 (35%), Positives = 131/247 (53%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + + + L+ GA + A+T+ G TP+H+AA GHL +V +LL+ G DV +
Sbjct: 381 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 440
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+TALH A G E++ L+ G +D + ++ T LH AS G ++ +LL++ A
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 500
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A G T LH++ + VLL AG+ L G T LHVAA+Y L + +L
Sbjct: 501 HPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 560
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G T LHVAA +++KVA +LLE GA G TPL A N
Sbjct: 561 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 620
Query: 253 PEVALLL 259
++A L
Sbjct: 621 MQIASTL 627
Score = 136 bits (342), Expect = 8e-32
Identities = 92/252 (36%), Positives = 128/252 (50%), Gaps = 2/252 (0%)
Query: 16 VAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG 74
VAA+ G V+ L+ GA VT G T LH+AA G + VV+ LL+ G +D +
Sbjct: 416 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE 475
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
+QT LH A+ +G TEI+ L+ D +G T LH ++ G A +L++AGA
Sbjct: 476 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 535
Query: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
K G T LH+A + ++LL + AD G T LHVAA Y++ + LLL
Sbjct: 536 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 595
Query: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
S H + G T LH+AA N ++A LL GA+T IV G TPL A + +
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 655
Query: 255 -VALLLTKAPQV 265
V LLL K +
Sbjct: 656 MVTLLLDKGANI 667
Score = 128 bits (321), Expect = 2e-29
Identities = 83/255 (32%), Positives = 128/255 (50%), Gaps = 9/255 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV---------TKHGRTPLHLAANKGHLPVVQILLKA 64
L +AA K T++ L+ V T+ G TPLH+AA+ G++ V +LL
Sbjct: 175 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234
Query: 65 GCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSA 124
G +D T LH A+ GNT ++ L+ G +D + +DG T LH A+ G Q
Sbjct: 235 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294
Query: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
+LL++ GA +LA+ K G + LH+A Q H + + LL + D T LHVAA
Sbjct: 295 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 354
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL 244
H + +LLL + + + G T LH+A N KV ++L++ GA + +G TP+
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 414
Query: 245 ETARYHNNPEVALLL 259
A + + + LLL
Sbjct: 415 HVAAFMGHLNIVLLL 429
Score = 127 bits (320), Expect = 3e-29
Identities = 83/249 (33%), Positives = 129/249 (51%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A+ G+TE V L+ A A T +G TPLH++A +G + V +LL+AG +
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 539
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ ++ L+ A D K+G T LH A+ + + A LL++ GA
Sbjct: 540 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 599
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A + + Q LL G+ ++ G T LH+A++ H ++ L
Sbjct: 600 SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 659
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL ++H ++G T+LH+AA + VA IL + GAD G TPL A ++ N
Sbjct: 660 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 719
Query: 253 PEVALLLTK 261
++ L K
Sbjct: 720 VKMVNFLLK 728
Score = 122 bits (307), Expect = 9e-28
Identities = 86/247 (34%), Positives = 123/247 (49%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA+ +G T V L+++G ++ A T+ G TPLH AA GH VV++LL+ G L +
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 308
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ LH A + E + L+ +D D TALH A+ G + KLL+ A
Sbjct: 309 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 368
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N A+ G T LH+AC+ + + +L+ G+ +G T +HVAA HL+I+ L
Sbjct: 369 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 428
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S N G+TALH+AA +V + LL GA QTPL A
Sbjct: 429 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 488
Query: 253 PEVALLL 259
E+ LL
Sbjct: 489 TEIVQLL 495
Score = 116 bits (290), Expect = 8e-26
Identities = 84/261 (32%), Positives = 123/261 (47%), Gaps = 14/261 (5%)
Query: 15 LVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
L AA G + VV+ + G + ++G LHLAA +GH+ +VQ LL G +D
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
TALH A++ G E++ L+ EG ++ Q ++G T L+ A+ K L++ GAN
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 134 VLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL 193
+ G T L +A Q H+Q+ +LL D K LH+AAR + LL
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALL 190
Query: 194 L--------TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
L + V+ ++G T LH+AA + VA +LL GA G TPL
Sbjct: 191 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 250
Query: 246 TARYHNNPE-VALLLTKAPQV 265
A N V LLL + Q+
Sbjct: 251 VASKRGNTNMVKLLLDRGGQI 271
Score = 108 bits (270), Expect = 2e-23
Identities = 75/236 (31%), Positives = 108/236 (45%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G + L+ + A + K+G TPLH+AA+ + V +LL+ G
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A +I + L++ G + K G T LH AS G + LL+ GA
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N+ K+G T+LHLA Q +L G+ D G T L VA Y ++ ++
Sbjct: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 725
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL +V+ K + G T LH AA H + +LL+ GA G T L A+
Sbjct: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
Score = 108 bits (269), Expect = 2e-23
Identities = 84/257 (32%), Positives = 121/257 (47%), Gaps = 13/257 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTP-LHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA +G + V L+ + V R P LH+AA K +LL+ + DVQ
Sbjct: 146 LAVALQQGHNQAVAILLENDTKGKV----RLPALHIAARKDDTKSAALLLQNDHNADVQS 201
Query: 73 --------DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSA 124
+ T LH A GN + L++ G A+D ++G T LH AS G +
Sbjct: 202 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 261
Query: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
KLL+ G + AK + G T LH A ++ H Q +LL G+ + G + LH+AA+
Sbjct: 262 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 321
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL 244
+H+ ++ LL V + TALHVAA H +V K+LL+ A+ G TPL
Sbjct: 322 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 381
Query: 245 ETARYHNNPEVALLLTK 261
A N +V LL K
Sbjct: 382 HIACKKNRIKVMELLVK 398
Score = 106 bits (265), Expect = 7e-23
Identities = 78/247 (31%), Positives = 117/247 (47%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA E V L+ A V VT T LH+AA+ GH V ++LL + + +
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A +++ L+ G ++ + G T +H A++ G LL++ GA
Sbjct: 375 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ N G TALH+A + + R LL G+ D + T LH+A+R I++L
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL G T LH++A VA +LLEAGA ++ G TPL A + +
Sbjct: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554
Query: 253 PEVALLL 259
+VA LL
Sbjct: 555 LDVAKLL 561
Score = 106 bits (265), Expect = 7e-23
Identities = 75/247 (30%), Positives = 114/247 (46%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L ++A +GQ + L+ GA ++ TK G TPLH+AA G L V ++LL+ D
Sbjct: 513 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 572
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N ++ L+ +G + K+G T LH A+ Q A L+ GA
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
K G T LHLA Q H+ +LL G+ + +G T LH+AA+ + +++ +
Sbjct: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L + G T L VA + K+ LL+ GA+ G TPL A +
Sbjct: 693 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 752
Query: 253 PEVALLL 259
+ +L
Sbjct: 753 THIINVL 759
Score = 105 bits (263), Expect = 1e-22
Identities = 73/225 (32%), Positives = 109/225 (48%), Gaps = 4/225 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ + + L+ KGA A K+G TPLH+AA K + + LL G + ++
Sbjct: 579 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 638
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A+ G+T+++ L+ +G + K G T+LH A+ A +L K GA
Sbjct: 639 KQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 698
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T L +AC + + LL G+ + K G T LH AA+ H II +
Sbjct: 699 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 758
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVA---KILLEAGADTT 234
LL + G+TAL +A L + V K++ E TT
Sbjct: 759 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 803
Score = 103 bits (258), Expect = 4e-22
Identities = 73/229 (31%), Positives = 110/229 (48%), Gaps = 12/229 (5%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA G+L V LK G D++ + ALH A G+ ++ L+ G ++D K G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH AS G ++ K+LVK GAN+ A+++ G T L++A Q +H + LL G+
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
G T L VA + H + +LL K + ALH+AA + K A +LL+
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 229 AGADTTI--------VNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ + +G TPL A ++ N VA LL + F+
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241
Score = 80.5 bits (197), Expect = 5e-15
Identities = 51/157 (32%), Positives = 79/157 (50%), Gaps = 1/157 (0%)
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLA 163
Q D N + A+ G +K G ++ N+ G ALHLA + H + LL
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
Query: 164 GSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVA 223
GS D G+T LH+A+ ++++L+ +++ ++Q G T L++AA NH V
Sbjct: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 224 KILLEAGADTTIVNNAGQTPLETA-RYHNNPEVALLL 259
K LLE GA+ + G TPL A + +N VA+LL
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Score = 73.6 bits (179), Expect = 6e-13
Identities = 45/159 (28%), Positives = 80/159 (50%)
Query: 70 VQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129
+Q + RA GN + + + G ++ +++G ALH A+ G + L+
Sbjct: 5 LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 130 AGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSI 189
G++V + K GNTALH+A ++ +VL+ G+ + ++ G T L++AA+ NH+ +
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
Query: 190 IRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
++ LL + + G T L VA H + ILLE
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE 163
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 139 bits (351), Expect = 7e-33
Identities = 88/247 (35%), Positives = 131/247 (53%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + + + L+ GA + A+T+ G TP+H+AA GHL +V +LL+ G DV +
Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+TALH A G E++ L+ G +D + ++ T LH AS G ++ +LL++ A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A G T LH++ + VLL AG+ L G T LHVAA+Y L + +L
Sbjct: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 581
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G T LHVAA +++KVA +LLE GA G TPL A N
Sbjct: 582 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 641
Query: 253 PEVALLL 259
++A L
Sbjct: 642 MQIASTL 648
Score = 136 bits (342), Expect = 8e-32
Identities = 92/252 (36%), Positives = 128/252 (50%), Gaps = 2/252 (0%)
Query: 16 VAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG 74
VAA+ G V+ L+ GA VT G T LH+AA G + VV+ LL+ G +D +
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE 496
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
+QT LH A+ +G TEI+ L+ D +G T LH ++ G A +L++AGA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
K G T LH+A + ++LL + AD G T LHVAA Y++ + LLL
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
S H + G T LH+AA N ++A LL GA+T IV G TPL A + +
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 255 -VALLLTKAPQV 265
V LLL K +
Sbjct: 677 MVTLLLDKGANI 688
Score = 128 bits (321), Expect = 2e-29
Identities = 83/255 (32%), Positives = 128/255 (50%), Gaps = 9/255 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV---------TKHGRTPLHLAANKGHLPVVQILLKA 64
L +AA K T++ L+ V T+ G TPLH+AA+ G++ V +LL
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 65 GCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSA 124
G +D T LH A+ GNT ++ L+ G +D + +DG T LH A+ G Q
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
Query: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
+LL++ GA +LA+ K G + LH+A Q H + + LL + D T LHVAA
Sbjct: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL 244
H + +LLL + + + G T LH+A N KV ++L++ GA + +G TP+
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Query: 245 ETARYHNNPEVALLL 259
A + + + LLL
Sbjct: 436 HVAAFMGHLNIVLLL 450
Score = 127 bits (320), Expect = 3e-29
Identities = 83/249 (33%), Positives = 129/249 (51%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A+ G+TE V L+ A A T +G TPLH++A +G + V +LL+AG +
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ ++ L+ A D K+G T LH A+ + + A LL++ GA
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A + + Q LL G+ ++ G T LH+A++ H ++ L
Sbjct: 621 SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 680
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL ++H ++G T+LH+AA + VA IL + GAD G TPL A ++ N
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740
Query: 253 PEVALLLTK 261
++ L K
Sbjct: 741 VKMVNFLLK 749
Score = 122 bits (307), Expect = 9e-28
Identities = 86/247 (34%), Positives = 123/247 (49%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA+ +G T V L+++G ++ A T+ G TPLH AA GH VV++LL+ G L +
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 329
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ LH A + E + L+ +D D TALH A+ G + KLL+ A
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N A+ G T LH+AC+ + + +L+ G+ +G T +HVAA HL+I+ L
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 449
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S N G+TALH+AA +V + LL GA QTPL A
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
Query: 253 PEVALLL 259
E+ LL
Sbjct: 510 TEIVQLL 516
Score = 116 bits (290), Expect = 8e-26
Identities = 84/261 (32%), Positives = 123/261 (47%), Gaps = 14/261 (5%)
Query: 15 LVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
L AA G + VV+ + G + ++G LHLAA +GH+ +VQ LL G +D
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
TALH A++ G E++ L+ EG ++ Q ++G T L+ A+ K L++ GAN
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 134 VLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL 193
+ G T L +A Q H+Q+ +LL D K LH+AAR + LL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALL 211
Query: 194 L--------TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
L + V+ ++G T LH+AA + VA +LL GA G TPL
Sbjct: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 271
Query: 246 TARYHNNPE-VALLLTKAPQV 265
A N V LLL + Q+
Sbjct: 272 VASKRGNTNMVKLLLDRGGQI 292
Score = 108 bits (270), Expect = 2e-23
Identities = 75/236 (31%), Positives = 108/236 (45%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G + L+ + A + K+G TPLH+AA+ + V +LL+ G
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A +I + L++ G + K G T LH AS G + LL+ GA
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N+ K+G T+LHLA Q +L G+ D G T L VA Y ++ ++
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL +V+ K + G T LH AA H + +LL+ GA G T L A+
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Score = 108 bits (269), Expect = 2e-23
Identities = 84/257 (32%), Positives = 121/257 (47%), Gaps = 13/257 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTP-LHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA +G + V L+ + V R P LH+AA K +LL+ + DVQ
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKV----RLPALHIAARKDDTKSAALLLQNDHNADVQS 222
Query: 73 --------DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSA 124
+ T LH A GN + L++ G A+D ++G T LH AS G +
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
KLL+ G + AK + G T LH A ++ H Q +LL G+ + G + LH+AA+
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL 244
+H+ ++ LL V + TALHVAA H +V K+LL+ A+ G TPL
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402
Query: 245 ETARYHNNPEVALLLTK 261
A N +V LL K
Sbjct: 403 HIACKKNRIKVMELLVK 419
Score = 106 bits (265), Expect = 7e-23
Identities = 78/247 (31%), Positives = 117/247 (47%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA E V L+ A V VT T LH+AA+ GH V ++LL + + +
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A +++ L+ G ++ + G T +H A++ G LL++ GA
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ N G TALH+A + + R LL G+ D + T LH+A+R I++L
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL G T LH++A VA +LLEAGA ++ G TPL A + +
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 253 PEVALLL 259
+VA LL
Sbjct: 576 LDVAKLL 582
Score = 106 bits (265), Expect = 7e-23
Identities = 75/247 (30%), Positives = 114/247 (46%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L ++A +GQ + L+ GA ++ TK G TPLH+AA G L V ++LL+ D
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N ++ L+ +G + K+G T LH A+ Q A L+ GA
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
K G T LHLA Q H+ +LL G+ + +G T LH+AA+ + +++ +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L + G T L VA + K+ LL+ GA+ G TPL A +
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 253 PEVALLL 259
+ +L
Sbjct: 774 THIINVL 780
Score = 105 bits (263), Expect = 1e-22
Identities = 73/225 (32%), Positives = 109/225 (48%), Gaps = 4/225 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ + + L+ KGA A K+G TPLH+AA K + + LL G + ++
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 659
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A+ G+T+++ L+ +G + K G T+LH A+ A +L K GA
Sbjct: 660 KQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T L +AC + + LL G+ + K G T LH AA+ H II +
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 779
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVA---KILLEAGADTT 234
LL + G+TAL +A L + V K++ E TT
Sbjct: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 824
Score = 103 bits (258), Expect = 4e-22
Identities = 73/229 (31%), Positives = 110/229 (48%), Gaps = 12/229 (5%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA G+L V LK G D++ + ALH A G+ ++ L+ G ++D K G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH AS G ++ K+LVK GAN+ A+++ G T L++A Q +H + LL G+
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
G T L VA + H + +LL K + ALH+AA + K A +LL+
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 229 AGADTTI--------VNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ + +G TPL A ++ N VA LL + F+
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Score = 79.0 bits (193), Expect = 1e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 1/154 (0%)
Query: 107 DGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR 166
D N + A+ G +K G ++ N+ G ALHLA + H + LL GS
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 167 ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKIL 226
D G+T LH+A+ ++++L+ +++ ++Q G T L++AA NH V K L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 227 LEAGADTTIVNNAGQTPLETA-RYHNNPEVALLL 259
LE GA+ + G TPL A + +N VA+LL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/123 (28%), Positives = 57/123 (46%)
Query: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196
K N + A + + L G + N G LH+AA+ H+ +++ LL
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 197 FCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVA 256
SV + G+TALH+A+ +V K+L++ GA+ + G TPL A N+ +V
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 257 LLL 259
L
Sbjct: 147 KYL 149
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 139 bits (351), Expect = 7e-33
Identities = 88/247 (35%), Positives = 131/247 (53%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + + + L+ GA + A+T+ G TP+H+AA GHL +V +LL+ G DV +
Sbjct: 402 LHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTN 461
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+TALH A G E++ L+ G +D + ++ T LH AS G ++ +LL++ A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A G T LH++ + VLL AG+ L G T LHVAA+Y L + +L
Sbjct: 522 HPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKL 581
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G T LHVAA +++KVA +LLE GA G TPL A N
Sbjct: 582 LLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQ 641
Query: 253 PEVALLL 259
++A L
Sbjct: 642 MQIASTL 648
Score = 136 bits (342), Expect = 8e-32
Identities = 92/252 (36%), Positives = 128/252 (50%), Gaps = 2/252 (0%)
Query: 16 VAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG 74
VAA+ G V+ L+ GA VT G T LH+AA G + VV+ LL+ G +D +
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE 496
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
+QT LH A+ +G TEI+ L+ D +G T LH ++ G A +L++AGA
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Query: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
K G T LH+A + ++LL + AD G T LHVAA Y++ + LLL
Sbjct: 557 SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
S H + G T LH+AA N ++A LL GA+T IV G TPL A + +
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 255 -VALLLTKAPQV 265
V LLL K +
Sbjct: 677 MVTLLLDKGANI 688
Score = 128 bits (321), Expect = 2e-29
Identities = 83/255 (32%), Positives = 128/255 (50%), Gaps = 9/255 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV---------TKHGRTPLHLAANKGHLPVVQILLKA 64
L +AA K T++ L+ V T+ G TPLH+AA+ G++ V +LL
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 65 GCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSA 124
G +D T LH A+ GNT ++ L+ G +D + +DG T LH A+ G Q
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
Query: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
+LL++ GA +LA+ K G + LH+A Q H + + LL + D T LHVAA
Sbjct: 316 ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL 244
H + +LLL + + + G T LH+A N KV ++L++ GA + +G TP+
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Query: 245 ETARYHNNPEVALLL 259
A + + + LLL
Sbjct: 436 HVAAFMGHLNIVLLL 450
Score = 127 bits (320), Expect = 3e-29
Identities = 83/249 (33%), Positives = 129/249 (51%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A+ G+TE V L+ A A T +G TPLH++A +G + V +LL+AG +
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ ++ L+ A D K+G T LH A+ + + A LL++ GA
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A + + Q LL G+ ++ G T LH+A++ H ++ L
Sbjct: 621 SPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 680
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL ++H ++G T+LH+AA + VA IL + GAD G TPL A ++ N
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740
Query: 253 PEVALLLTK 261
++ L K
Sbjct: 741 VKMVNFLLK 749
Score = 122 bits (307), Expect = 9e-28
Identities = 86/247 (34%), Positives = 123/247 (49%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA+ +G T V L+++G ++ A T+ G TPLH AA GH VV++LL+ G L +
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 329
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ LH A + E + L+ +D D TALH A+ G + KLL+ A
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N A+ G T LH+AC+ + + +L+ G+ +G T +HVAA HL+I+ L
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLL 449
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S N G+TALH+AA +V + LL GA QTPL A
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
Query: 253 PEVALLL 259
E+ LL
Sbjct: 510 TEIVQLL 516
Score = 116 bits (290), Expect = 8e-26
Identities = 84/261 (32%), Positives = 123/261 (47%), Gaps = 14/261 (5%)
Query: 15 LVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
L AA G + VV+ + G + ++G LHLAA +GH+ +VQ LL G +D
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
TALH A++ G E++ L+ EG ++ Q ++G T L+ A+ K L++ GAN
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 134 VLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL 193
+ G T L +A Q H+Q+ +LL D K LH+AAR + LL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALL 211
Query: 194 L--------TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
L + V+ ++G T LH+AA + VA +LL GA G TPL
Sbjct: 212 LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 271
Query: 246 TARYHNNPE-VALLLTKAPQV 265
A N V LLL + Q+
Sbjct: 272 VASKRGNTNMVKLLLDRGGQI 292
Score = 108 bits (270), Expect = 2e-23
Identities = 75/236 (31%), Positives = 108/236 (45%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G + L+ + A + K+G TPLH+AA+ + V +LL+ G
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A +I + L++ G + K G T LH AS G + LL+ GA
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N+ K+G T+LHLA Q +L G+ D G T L VA Y ++ ++
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL +V+ K + G T LH AA H + +LL+ GA G T L A+
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Score = 108 bits (269), Expect = 2e-23
Identities = 84/257 (32%), Positives = 121/257 (47%), Gaps = 13/257 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTP-LHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA +G + V L+ + V R P LH+AA K +LL+ + DVQ
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKV----RLPALHIAARKDDTKSAALLLQNDHNADVQS 222
Query: 73 --------DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSA 124
+ T LH A GN + L++ G A+D ++G T LH AS G +
Sbjct: 223 KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 282
Query: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
KLL+ G + AK + G T LH A ++ H Q +LL G+ + G + LH+AA+
Sbjct: 283 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL 244
+H+ ++ LL V + TALHVAA H +V K+LL+ A+ G TPL
Sbjct: 343 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPL 402
Query: 245 ETARYHNNPEVALLLTK 261
A N +V LL K
Sbjct: 403 HIACKKNRIKVMELLVK 419
Score = 106 bits (265), Expect = 7e-23
Identities = 78/247 (31%), Positives = 117/247 (47%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA E V L+ A V VT T LH+AA+ GH V ++LL + + +
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A +++ L+ G ++ + G T +H A++ G LL++ GA
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ N G TALH+A + + R LL G+ D + T LH+A+R I++L
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL G T LH++A VA +LLEAGA ++ G TPL A + +
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 253 PEVALLL 259
+VA LL
Sbjct: 576 LDVAKLL 582
Score = 106 bits (265), Expect = 7e-23
Identities = 75/247 (30%), Positives = 114/247 (46%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L ++A +GQ + L+ GA ++ TK G TPLH+AA G L V ++LL+ D
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N ++ L+ +G + K+G T LH A+ Q A L+ GA
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
K G T LHLA Q H+ +LL G+ + +G T LH+AA+ + +++ +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L + G T L VA + K+ LL+ GA+ G TPL A +
Sbjct: 714 LTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 253 PEVALLL 259
+ +L
Sbjct: 774 THIINVL 780
Score = 105 bits (263), Expect = 1e-22
Identities = 73/225 (32%), Positives = 109/225 (48%), Gaps = 4/225 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ + + L+ KGA A K+G TPLH+AA K + + LL G + ++
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 659
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A+ G+T+++ L+ +G + K G T+LH A+ A +L K GA
Sbjct: 660 KQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T L +AC + + LL G+ + K G T LH AA+ H II +
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 779
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVA---KILLEAGADTT 234
LL + G+TAL +A L + V K++ E TT
Sbjct: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTT 824
Score = 103 bits (258), Expect = 4e-22
Identities = 73/229 (31%), Positives = 110/229 (48%), Gaps = 12/229 (5%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA G+L V LK G D++ + ALH A G+ ++ L+ G ++D K G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH AS G ++ K+LVK GAN+ A+++ G T L++A Q +H + LL G+
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
G T L VA + H + +LL K + ALH+AA + K A +LL+
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 229 AGADTTI--------VNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ + +G TPL A ++ N VA LL + F+
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Score = 79.0 bits (193), Expect = 1e-14
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 1/154 (0%)
Query: 107 DGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR 166
D N + A+ G +K G ++ N+ G ALHLA + H + LL GS
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 167 ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKIL 226
D G+T LH+A+ ++++L+ +++ ++Q G T L++AA NH V K L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 227 LEAGADTTIVNNAGQTPLETA-RYHNNPEVALLL 259
LE GA+ + G TPL A + +N VA+LL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/123 (28%), Positives = 57/123 (46%)
Query: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196
K N + A + + L G + N G LH+AA+ H+ +++ LL
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 197 FCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVA 256
SV + G+TALH+A+ +V K+L++ GA+ + G TPL A N+ +V
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 257 LLL 259
L
Sbjct: 147 KYL 149
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 138 bits (347), Expect = 2e-32
Identities = 98/341 (28%), Positives = 170/341 (49%), Gaps = 51/341 (14%)
Query: 1 MSQQDAVAALSER--------LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAAN 51
+ ++DAV AL+E LL++A+ G + L+N GA++ +K G T LH AA
Sbjct: 74 VDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQ 133
Query: 52 KGHLPVVQILLK-----------------------------------AGCDLDVQDDGDQ 76
KGH+PV+ +++ +GCD +V+D
Sbjct: 134 KGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGN 193
Query: 77 TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLA 136
TALH A G+ ++ L+ G L+ Q+ +G TALH A+ +LL++AG+ V A
Sbjct: 194 TALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA 253
Query: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196
+ + LH A + +RVL+ AG A++ ++ G + LH+A R+N +++RLL+ +
Sbjct: 254 LTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINS 313
Query: 197 FCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVA 256
V+ + T LH+AA + +A +LL AG D + + G+T L A N+ +
Sbjct: 314 DSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLV 373
Query: 257 LLLTKAPQVLRFSR-------GRSLRKKRERLKEERRAQSV 290
++ KA + R+ + G+SL K++ +E ++ +SV
Sbjct: 374 DMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSV 414
Score = 116 bits (290), Expect = 8e-26
Identities = 88/303 (29%), Positives = 131/303 (43%), Gaps = 46/303 (15%)
Query: 3 QQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKH-GRTPLHLAANK--------- 52
+ D + L +L AA + + +LI + H GR LH AA
Sbjct: 8 ETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLL 67
Query: 53 ----------------------------------GHLPVVQILLKAGCDLDVQDDGDQTA 78
GHL ++QIL+ +G + + T
Sbjct: 68 LEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTL 127
Query: 79 LHRATVVGNTEIIAALIH--EGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLA 136
LH A G+ ++A ++ E ALD DK G TA H A+ HG + LV +G +
Sbjct: 128 LHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNV 187
Query: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196
K+K GNTALHLA H + L+ G + +N G T LH AA +H ++LLL A
Sbjct: 188 KDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRA 247
Query: 197 FCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVA 256
+V+ Q + LH AA + V+++L+ AG +V++ G +PL A HN P +
Sbjct: 248 GSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALV 307
Query: 257 LLL 259
LL
Sbjct: 308 RLL 310
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 137 bits (345), Expect = 3e-32
Identities = 87/247 (35%), Positives = 129/247 (52%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ G L++KGA+ + +G TPLH+A K H+ V+++LLK G +D
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ T LH A+ +G+ I+ L+ G + + + T LH A+ G ++ AK L++ A
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V AK K T LH A + H+ ++LL + +L AG T LH+AAR H+ +
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 554
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + G T LHVAA +VA++LLE A G TPL A +HNN
Sbjct: 555 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 614
Query: 253 PEVALLL 259
++ LL
Sbjct: 615 LDIVKLL 621
Score = 127 bits (318), Expect = 5e-29
Identities = 84/244 (34%), Positives = 121/244 (49%), Gaps = 1/244 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + L+ GA + AVT+ G TPLH+A+ GHLP+V+ LL+ G +V +
Sbjct: 408 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+T LH A G+TE+ L+ ++ + KD T LH A+ G + KLL++ A
Sbjct: 468 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 527
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N AG+T LH+A + H ++ LL + G T LHVAA+Y + + L
Sbjct: 528 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 587
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G T LHVA N+ + K+LL G G TPL A N
Sbjct: 588 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 647
Query: 253 PEVA 256
EVA
Sbjct: 648 VEVA 651
Score = 120 bits (302), Expect = 3e-27
Identities = 83/258 (32%), Positives = 129/258 (50%), Gaps = 3/258 (1%)
Query: 17 AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
AA G L++ GA + A TK+G +P+H+AA HL V++LL+ ++D
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
T LH A G+ + L+ +G + + +G T LH A + +LL+K GA++
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
A ++G T LH+A H + LL G+ ++ N +T LH+AAR H + + LL
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 491
Query: 196 AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE- 254
V+ K + T LH AA + H + K+LLE A+ + AG TPL A + E
Sbjct: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 551
Query: 255 -VALLLTKAPQVLRFSRG 271
+ALL +A Q +G
Sbjct: 552 VLALLEKEASQACMTKKG 569
Score = 120 bits (300), Expect = 6e-27
Identities = 83/250 (33%), Positives = 124/250 (49%), Gaps = 2/250 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA++ G V L+ +GA V+ TPLH+AA GH V + LL+ ++ +
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
DQT LH A +G+T ++ L+ + G+T LH A+ G ++ L++ A
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 560
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K G T LH+A + + +LL + + G T LHVA +N+L I++L
Sbjct: 561 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 620
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S H G T LH+AA N +VA+ LL+ G + G TPL A +
Sbjct: 621 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 680
Query: 253 PE-VALLLTK 261
E VALLL+K
Sbjct: 681 AEMVALLLSK 690
Score = 119 bits (298), Expect = 1e-26
Identities = 82/248 (33%), Positives = 124/248 (50%), Gaps = 2/248 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A+ +G V L+++GA++ TK TPLH AA GH+ + +ILL G + +
Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 335
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ +H A + + + L+ +D D T LH A+ G + AK+L+ GA
Sbjct: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
++ G T LH+AC+ +H + +LL G+ D +G T LHVA+ HL I++
Sbjct: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE-TARYHN 251
LL S + N +T LH+AA H +VAK LL+ A QTPL AR +
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515
Query: 252 NPEVALLL 259
V LLL
Sbjct: 516 TNMVKLLL 523
Score = 118 bits (296), Expect = 2e-26
Identities = 79/249 (31%), Positives = 124/249 (49%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA +G E V+ L+ K A A +TK G TPLH+AA G + V ++LL+ +
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N +I+ L+ G + +G T LH A+ + A+ L++ G
Sbjct: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A++ G T LHLA Q H++ +LL + +L N +G T LH+ A+ H+ + +
Sbjct: 660 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 719
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L+ V + G T LHVA+ + K+ K LL+ AD G +PL A +
Sbjct: 720 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 779
Query: 253 PEVALLLTK 261
++ LL K
Sbjct: 780 TDIVTLLLK 788
Score = 116 bits (291), Expect = 6e-26
Identities = 77/236 (32%), Positives = 114/236 (48%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G+ L+ + A A K+G TPLH+A + +L +V++LL G
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A E+ +L+ G + + + G T LH A+ G ++ LL+ A
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 692
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N NK+G T LHL Q H VL+ G D G T LHVA+ Y ++ +++
Sbjct: 693 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 752
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL V+ K + G + LH AA H + +LL+ GA V++ G TPL A+
Sbjct: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808
Score = 114 bits (286), Expect = 2e-25
Identities = 81/249 (32%), Positives = 126/249 (50%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA G TE L+ A+V A K +TPLH AA GH +V++LL+ + ++
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E + AL+ + + K G T LH A+ +G + A+LL++ A
Sbjct: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A +++ ++LL G G T LH+AA+ N + + R
Sbjct: 594 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + ++ G T LH+AA H ++ +LL A+ + N +G TPL +
Sbjct: 654 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 713
Query: 253 PEVALLLTK 261
VA +L K
Sbjct: 714 VPVADVLIK 722
Score = 110 bits (276), Expect = 4e-24
Identities = 79/247 (31%), Positives = 130/247 (52%), Gaps = 5/247 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA GQ E V +L+N GA V A ++ G TPL++AA + HL VV+ LL+ G + +V
Sbjct: 115 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 174
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ T L A G+ ++A LI+ G + K ALH A+ + +++A +L++
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYG----TKGKVRLPALHIAARNDDTRTAAVLLQNDP 230
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N +K G T LH+A + ++LL G+ + G T LH+A+R ++ ++RL
Sbjct: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRL 290
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + K + T LH AA H ++++ILL+ GA G +P+ A ++
Sbjct: 291 LLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDH 350
Query: 253 PEVALLL 259
+ LL
Sbjct: 351 LDCVRLL 357
Score = 110 bits (275), Expect = 5e-24
Identities = 84/249 (33%), Positives = 118/249 (47%), Gaps = 5/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTP-LHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA +G V LIN G + V R P LH+AA +LL+ + DV
Sbjct: 181 LAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNPDVLS 236
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N + L++ G +++ ++G T LH AS G +LL+ GA
Sbjct: 237 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 296
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K K T LH A +N H + + +LL G+ K G + +H+AA+ +HL +RL
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + T LHVAA H +VAK+LL+ GA G TPL A N+
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 416
Query: 253 PEVALLLTK 261
V LL K
Sbjct: 417 VRVMELLLK 425
Score = 102 bits (255), Expect = 1e-21
Identities = 66/221 (29%), Positives = 113/221 (51%), Gaps = 4/221 (1%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA G+L L+ G D++ + LH A+ G+ +++ L+H+ L+ K G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH A+ G + + LV GANV A+++ G T L++A Q +H + + LL G+ +
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
+ G T L VA + H +++ L+ + K + ALH+AA + + A +LL+
Sbjct: 172 VATEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ 227
Query: 229 AGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ +++ G TPL A ++ N VA LL + F+
Sbjct: 228 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Score = 102 bits (254), Expect = 1e-21
Identities = 76/275 (27%), Positives = 126/275 (45%), Gaps = 30/275 (10%)
Query: 15 LVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
L AA G + + + G + ++G LHLA+ +GH+ +V LL L+
Sbjct: 50 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 109
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA- 132
TALH A + G E++ L++ G ++ Q + G T L+ A+ + K L++ GA
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 169
Query: 133 ---------------------NVLA-------KNKAGNTALHLACQNSHSQSTRVLLLAG 164
NV+A K K ALH+A +N +++ VLL
Sbjct: 170 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 229
Query: 165 SRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224
D+ + G T LH+AA Y +L++ +LLL SV+ Q G T LH+A+ + + +
Sbjct: 230 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVR 289
Query: 225 ILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
+LL+ GA TPL A + + ++ +L
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
Score = 93.6 bits (231), Expect = 6e-19
Identities = 91/351 (25%), Positives = 152/351 (43%), Gaps = 18/351 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA + + V L+ +G + +G TPLH+AA + + V + LL+ G + +
Sbjct: 606 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 665
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E++A L+ + + +K G T LH + G A +L+K G
Sbjct: 666 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 725
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V A + G T LH+A + + + LL + + K G + LH AA+ H I+ L
Sbjct: 726 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 785
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV-------NNAGQTPLE 245
LL S +E + G T L +A L + V +L +T+ V + +T E
Sbjct: 786 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 845
Query: 246 TARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPR-DEVAQSKG---- 300
+ A + +++ F R R R+ +E+ VP+ D+V +S
Sbjct: 846 ILDVSEDEGTAHITIMGEELISFKAER--RDSRDVDEEKELLDFVPKLDQVVESPAIPRI 903
Query: 301 SVSAGDT---PSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAF 348
+ +T S EQ A KE + + +SP D+ + P + F
Sbjct: 904 PCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGF 954
Score = 69.3 bits (168), Expect = 1e-11
Identities = 48/155 (30%), Positives = 74/155 (47%), Gaps = 1/155 (0%)
Query: 102 DRQDK-DGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL 160
DR+ K D T+ A+ G A ++ G ++ N+ G LHLA + H + L
Sbjct: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
Query: 161 LLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHK 220
L + G+T LH+AA ++R L+ +V+ ++Q G T L++AA NH
Sbjct: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 157
Query: 221 KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEV 255
+V K LLE GA+ + G TPL A + V
Sbjct: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 192
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 137 bits (345), Expect = 3e-32
Identities = 87/247 (35%), Positives = 129/247 (52%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ G L++KGA+ + +G TPLH+A K H+ V+++LLK G +D
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ T LH A+ +G+ I+ L+ G + + + T LH A+ G ++ AK L++ A
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V AK K T LH A + H+ ++LL + +L AG T LH+AAR H+ +
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + G T LHVAA +VA++LLE A G TPL A +HNN
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
Query: 253 PEVALLL 259
++ LL
Sbjct: 582 LDIVKLL 588
Score = 127 bits (318), Expect = 5e-29
Identities = 84/244 (34%), Positives = 121/244 (49%), Gaps = 1/244 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + L+ GA + AVT+ G TPLH+A+ GHLP+V+ LL+ G +V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+T LH A G+TE+ L+ ++ + KD T LH A+ G + KLL++ A
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N AG+T LH+A + H ++ LL + G T LHVAA+Y + + L
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G T LHVA N+ + K+LL G G TPL A N
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 253 PEVA 256
EVA
Sbjct: 615 VEVA 618
Score = 120 bits (302), Expect = 3e-27
Identities = 83/258 (32%), Positives = 129/258 (50%), Gaps = 3/258 (1%)
Query: 17 AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
AA G L++ GA + A TK+G +P+H+AA HL V++LL+ ++D
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
T LH A G+ + L+ +G + + +G T LH A + +LL+K GA++
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
A ++G T LH+A H + LL G+ ++ N +T LH+AAR H + + LL
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 196 AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE- 254
V+ K + T LH AA + H + K+LLE A+ + AG TPL A + E
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518
Query: 255 -VALLLTKAPQVLRFSRG 271
+ALL +A Q +G
Sbjct: 519 VLALLEKEASQACMTKKG 536
Score = 120 bits (300), Expect = 6e-27
Identities = 83/250 (33%), Positives = 124/250 (49%), Gaps = 2/250 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA++ G V L+ +GA V+ TPLH+AA GH V + LL+ ++ +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
DQT LH A +G+T ++ L+ + G+T LH A+ G ++ L++ A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K G T LH+A + + +LL + + G T LHVA +N+L I++L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S H G T LH+AA N +VA+ LL+ G + G TPL A +
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Query: 253 PE-VALLLTK 261
E VALLL+K
Sbjct: 648 AEMVALLLSK 657
Score = 119 bits (298), Expect = 1e-26
Identities = 82/248 (33%), Positives = 124/248 (50%), Gaps = 2/248 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A+ +G V L+++GA++ TK TPLH AA GH+ + +ILL G + +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ +H A + + + L+ +D D T LH A+ G + AK+L+ GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
++ G T LH+AC+ +H + +LL G+ D +G T LHVA+ HL I++
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE-TARYHN 251
LL S + N +T LH+AA H +VAK LL+ A QTPL AR +
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 252 NPEVALLL 259
V LLL
Sbjct: 483 TNMVKLLL 490
Score = 118 bits (296), Expect = 2e-26
Identities = 79/249 (31%), Positives = 124/249 (49%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA +G E V+ L+ K A A +TK G TPLH+AA G + V ++LL+ +
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N +I+ L+ G + +G T LH A+ + A+ L++ G
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A++ G T LHLA Q H++ +LL + +L N +G T LH+ A+ H+ + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L+ V + G T LHVA+ + K+ K LL+ AD G +PL A +
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 253 PEVALLLTK 261
++ LL K
Sbjct: 747 TDIVTLLLK 755
Score = 116 bits (291), Expect = 6e-26
Identities = 77/236 (32%), Positives = 114/236 (48%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G+ L+ + A A K+G TPLH+A + +L +V++LL G
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A E+ +L+ G + + + G T LH A+ G ++ LL+ A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N NK+G T LHL Q H VL+ G D G T LHVA+ Y ++ +++
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL V+ K + G + LH AA H + +LL+ GA V++ G TPL A+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 114 bits (286), Expect = 2e-25
Identities = 81/249 (32%), Positives = 126/249 (50%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA G TE L+ A+V A K +TPLH AA GH +V++LL+ + ++
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E + AL+ + + K G T LH A+ +G + A+LL++ A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A +++ ++LL G G T LH+AA+ N + + R
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + ++ G T LH+AA H ++ +LL A+ + N +G TPL +
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 253 PEVALLLTK 261
VA +L K
Sbjct: 681 VPVADVLIK 689
Score = 110 bits (275), Expect = 5e-24
Identities = 84/249 (33%), Positives = 118/249 (47%), Gaps = 5/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTP-LHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA +G V LIN G + V R P LH+AA +LL+ + DV
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N + L++ G +++ ++G T LH AS G +LL+ GA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K K T LH A +N H + + +LL G+ K G + +H+AA+ +HL +RL
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + T LHVAA H +VAK+LL+ GA G TPL A N+
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 253 PEVALLLTK 261
V LL K
Sbjct: 384 VRVMELLLK 392
Score = 103 bits (256), Expect = 7e-22
Identities = 80/286 (27%), Positives = 132/286 (46%), Gaps = 32/286 (11%)
Query: 4 QDAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILL 62
++A AA S L AA G + + + G + ++G LHLA+ +GH+ +V LL
Sbjct: 8 READAATS--FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 63 KAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQ 122
L+ TALH A + G E++ L++ G ++ Q + G T L+ A+ +
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 123 SAKLLVKAGA----------------------NVLA-------KNKAGNTALHLACQNSH 153
K L++ GA NV+A K K ALH+A +N
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 185
Query: 154 SQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213
+++ VLL D+ + G T LH+AA Y +L++ +LLL SV+ Q G T LH+
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
A+ + + ++LL+ GA TPL A + + ++ +L
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 102 bits (255), Expect = 1e-21
Identities = 66/221 (29%), Positives = 113/221 (51%), Gaps = 4/221 (1%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA G+L L+ G D++ + LH A+ G+ +++ L+H+ L+ K G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH A+ G + + LV GANV A+++ G T L++A Q +H + + LL G+ +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
+ G T L VA + H +++ L+ + K + ALH+AA + + A +LL+
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 229 AGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ +++ G TPL A ++ N VA LL + F+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Score = 90.5 bits (223), Expect = 5e-18
Identities = 91/347 (26%), Positives = 149/347 (42%), Gaps = 18/347 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA + + V L+ +G + +G TPLH+AA + + V + LL+ G + +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E++A L+ + + +K G T LH + G A +L+K G
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V A + G T LH+A + + + LL + + K G + LH AA+ H I+ L
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV-------NNAGQTPLE 245
LL S +E + G T L +A L + V +L +T+ V + +T E
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 812
Query: 246 TARYHNNPEVALLLTKAPQVLRFSRGRSLRKKR----ERLKEERRAQSVPRDEVAQSKGS 301
+ L+ KA + R SR K+ +L + + ++PR A +
Sbjct: 813 ILDVSEDEGEELISFKAER--RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
Query: 302 VSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAF 348
V S EQ A KE + + +SP D+ + P + F
Sbjct: 871 V----IRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGF 913
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 137 bits (345), Expect = 3e-32
Identities = 87/247 (35%), Positives = 129/247 (52%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ G L++KGA+ + +G TPLH+A K H+ V+++LLK G +D
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ T LH A+ +G+ I+ L+ G + + + T LH A+ G ++ AK L++ A
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V AK K T LH A + H+ ++LL + +L AG T LH+AAR H+ +
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + G T LHVAA +VA++LLE A G TPL A +HNN
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
Query: 253 PEVALLL 259
++ LL
Sbjct: 582 LDIVKLL 588
Score = 127 bits (318), Expect = 5e-29
Identities = 84/244 (34%), Positives = 121/244 (49%), Gaps = 1/244 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + L+ GA + AVT+ G TPLH+A+ GHLP+V+ LL+ G +V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+T LH A G+TE+ L+ ++ + KD T LH A+ G + KLL++ A
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N AG+T LH+A + H ++ LL + G T LHVAA+Y + + L
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G T LHVA N+ + K+LL G G TPL A N
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 253 PEVA 256
EVA
Sbjct: 615 VEVA 618
Score = 120 bits (302), Expect = 3e-27
Identities = 83/258 (32%), Positives = 129/258 (50%), Gaps = 3/258 (1%)
Query: 17 AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
AA G L++ GA + A TK+G +P+H+AA HL V++LL+ ++D
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
T LH A G+ + L+ +G + + +G T LH A + +LL+K GA++
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
A ++G T LH+A H + LL G+ ++ N +T LH+AAR H + + LL
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 196 AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE- 254
V+ K + T LH AA + H + K+LLE A+ + AG TPL A + E
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518
Query: 255 -VALLLTKAPQVLRFSRG 271
+ALL +A Q +G
Sbjct: 519 VLALLEKEASQACMTKKG 536
Score = 120 bits (300), Expect = 6e-27
Identities = 83/250 (33%), Positives = 124/250 (49%), Gaps = 2/250 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA++ G V L+ +GA V+ TPLH+AA GH V + LL+ ++ +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
DQT LH A +G+T ++ L+ + G+T LH A+ G ++ L++ A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K G T LH+A + + +LL + + G T LHVA +N+L I++L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S H G T LH+AA N +VA+ LL+ G + G TPL A +
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Query: 253 PE-VALLLTK 261
E VALLL+K
Sbjct: 648 AEMVALLLSK 657
Score = 119 bits (298), Expect = 1e-26
Identities = 82/248 (33%), Positives = 124/248 (50%), Gaps = 2/248 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A+ +G V L+++GA++ TK TPLH AA GH+ + +ILL G + +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ +H A + + + L+ +D D T LH A+ G + AK+L+ GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
++ G T LH+AC+ +H + +LL G+ D +G T LHVA+ HL I++
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE-TARYHN 251
LL S + N +T LH+AA H +VAK LL+ A QTPL AR +
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 252 NPEVALLL 259
V LLL
Sbjct: 483 TNMVKLLL 490
Score = 118 bits (296), Expect = 2e-26
Identities = 79/249 (31%), Positives = 124/249 (49%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA +G E V+ L+ K A A +TK G TPLH+AA G + V ++LL+ +
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N +I+ L+ G + +G T LH A+ + A+ L++ G
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A++ G T LHLA Q H++ +LL + +L N +G T LH+ A+ H+ + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L+ V + G T LHVA+ + K+ K LL+ AD G +PL A +
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 253 PEVALLLTK 261
++ LL K
Sbjct: 747 TDIVTLLLK 755
Score = 116 bits (291), Expect = 6e-26
Identities = 77/236 (32%), Positives = 114/236 (48%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G+ L+ + A A K+G TPLH+A + +L +V++LL G
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A E+ +L+ G + + + G T LH A+ G ++ LL+ A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N NK+G T LHL Q H VL+ G D G T LHVA+ Y ++ +++
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL V+ K + G + LH AA H + +LL+ GA V++ G TPL A+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 114 bits (286), Expect = 2e-25
Identities = 81/249 (32%), Positives = 126/249 (50%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA G TE L+ A+V A K +TPLH AA GH +V++LL+ + ++
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E + AL+ + + K G T LH A+ +G + A+LL++ A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A +++ ++LL G G T LH+AA+ N + + R
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + ++ G T LH+AA H ++ +LL A+ + N +G TPL +
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 253 PEVALLLTK 261
VA +L K
Sbjct: 681 VPVADVLIK 689
Score = 110 bits (275), Expect = 5e-24
Identities = 84/249 (33%), Positives = 118/249 (47%), Gaps = 5/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTP-LHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA +G V LIN G + V R P LH+AA +LL+ + DV
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N + L++ G +++ ++G T LH AS G +LL+ GA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K K T LH A +N H + + +LL G+ K G + +H+AA+ +HL +RL
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + T LHVAA H +VAK+LL+ GA G TPL A N+
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 253 PEVALLLTK 261
V LL K
Sbjct: 384 VRVMELLLK 392
Score = 103 bits (256), Expect = 7e-22
Identities = 80/286 (27%), Positives = 132/286 (46%), Gaps = 32/286 (11%)
Query: 4 QDAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILL 62
++A AA S L AA G + + + G + ++G LHLA+ +GH+ +V LL
Sbjct: 8 READAATS--FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 63 KAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQ 122
L+ TALH A + G E++ L++ G ++ Q + G T L+ A+ +
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 123 SAKLLVKAGA----------------------NVLA-------KNKAGNTALHLACQNSH 153
K L++ GA NV+A K K ALH+A +N
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 185
Query: 154 SQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213
+++ VLL D+ + G T LH+AA Y +L++ +LLL SV+ Q G T LH+
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
A+ + + ++LL+ GA TPL A + + ++ +L
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 102 bits (255), Expect = 1e-21
Identities = 66/221 (29%), Positives = 113/221 (51%), Gaps = 4/221 (1%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA G+L L+ G D++ + LH A+ G+ +++ L+H+ L+ K G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH A+ G + + LV GANV A+++ G T L++A Q +H + + LL G+ +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
+ G T L VA + H +++ L+ + K + ALH+AA + + A +LL+
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 229 AGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ +++ G TPL A ++ N VA LL + F+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Score = 90.5 bits (223), Expect = 5e-18
Identities = 91/347 (26%), Positives = 149/347 (42%), Gaps = 18/347 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA + + V L+ +G + +G TPLH+AA + + V + LL+ G + +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E++A L+ + + +K G T LH + G A +L+K G
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V A + G T LH+A + + + LL + + K G + LH AA+ H I+ L
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV-------NNAGQTPLE 245
LL S +E + G T L +A L + V +L +T+ V + +T E
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 812
Query: 246 TARYHNNPEVALLLTKAPQVLRFSRGRSLRKKR----ERLKEERRAQSVPRDEVAQSKGS 301
+ L+ KA + R SR K+ +L + + ++PR A +
Sbjct: 813 ILDVSEDEGEELISFKAER--RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
Query: 302 VSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAF 348
V S EQ A KE + + +SP D+ + P + F
Sbjct: 871 V----IRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGF 913
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 137 bits (345), Expect = 3e-32
Identities = 87/247 (35%), Positives = 129/247 (52%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ G L++KGA+ + +G TPLH+A K H+ V+++LLK G +D
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ T LH A+ +G+ I+ L+ G + + + T LH A+ G ++ AK L++ A
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V AK K T LH A + H+ ++LL + +L AG T LH+AAR H+ +
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + G T LHVAA +VA++LLE A G TPL A +HNN
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
Query: 253 PEVALLL 259
++ LL
Sbjct: 582 LDIVKLL 588
Score = 127 bits (318), Expect = 5e-29
Identities = 84/244 (34%), Positives = 121/244 (49%), Gaps = 1/244 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + L+ GA + AVT+ G TPLH+A+ GHLP+V+ LL+ G +V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+T LH A G+TE+ L+ ++ + KD T LH A+ G + KLL++ A
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N AG+T LH+A + H ++ LL + G T LHVAA+Y + + L
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G T LHVA N+ + K+LL G G TPL A N
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 253 PEVA 256
EVA
Sbjct: 615 VEVA 618
Score = 120 bits (302), Expect = 3e-27
Identities = 83/258 (32%), Positives = 129/258 (50%), Gaps = 3/258 (1%)
Query: 17 AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
AA G L++ GA + A TK+G +P+H+AA HL V++LL+ ++D
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
T LH A G+ + L+ +G + + +G T LH A + +LL+K GA++
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
A ++G T LH+A H + LL G+ ++ N +T LH+AAR H + + LL
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 196 AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE- 254
V+ K + T LH AA + H + K+LLE A+ + AG TPL A + E
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518
Query: 255 -VALLLTKAPQVLRFSRG 271
+ALL +A Q +G
Sbjct: 519 VLALLEKEASQACMTKKG 536
Score = 120 bits (300), Expect = 6e-27
Identities = 83/250 (33%), Positives = 124/250 (49%), Gaps = 2/250 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA++ G V L+ +GA V+ TPLH+AA GH V + LL+ ++ +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
DQT LH A +G+T ++ L+ + G+T LH A+ G ++ L++ A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K G T LH+A + + +LL + + G T LHVA +N+L I++L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S H G T LH+AA N +VA+ LL+ G + G TPL A +
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Query: 253 PE-VALLLTK 261
E VALLL+K
Sbjct: 648 AEMVALLLSK 657
Score = 119 bits (298), Expect = 1e-26
Identities = 82/248 (33%), Positives = 124/248 (50%), Gaps = 2/248 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A+ +G V L+++GA++ TK TPLH AA GH+ + +ILL G + +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ +H A + + + L+ +D D T LH A+ G + AK+L+ GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
++ G T LH+AC+ +H + +LL G+ D +G T LHVA+ HL I++
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE-TARYHN 251
LL S + N +T LH+AA H +VAK LL+ A QTPL AR +
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 252 NPEVALLL 259
V LLL
Sbjct: 483 TNMVKLLL 490
Score = 118 bits (296), Expect = 2e-26
Identities = 79/249 (31%), Positives = 124/249 (49%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA +G E V+ L+ K A A +TK G TPLH+AA G + V ++LL+ +
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N +I+ L+ G + +G T LH A+ + A+ L++ G
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A++ G T LHLA Q H++ +LL + +L N +G T LH+ A+ H+ + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L+ V + G T LHVA+ + K+ K LL+ AD G +PL A +
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 253 PEVALLLTK 261
++ LL K
Sbjct: 747 TDIVTLLLK 755
Score = 116 bits (291), Expect = 6e-26
Identities = 77/236 (32%), Positives = 114/236 (48%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G+ L+ + A A K+G TPLH+A + +L +V++LL G
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A E+ +L+ G + + + G T LH A+ G ++ LL+ A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N NK+G T LHL Q H VL+ G D G T LHVA+ Y ++ +++
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL V+ K + G + LH AA H + +LL+ GA V++ G TPL A+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 114 bits (286), Expect = 2e-25
Identities = 81/249 (32%), Positives = 126/249 (50%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA G TE L+ A+V A K +TPLH AA GH +V++LL+ + ++
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E + AL+ + + K G T LH A+ +G + A+LL++ A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A +++ ++LL G G T LH+AA+ N + + R
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + ++ G T LH+AA H ++ +LL A+ + N +G TPL +
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 253 PEVALLLTK 261
VA +L K
Sbjct: 681 VPVADVLIK 689
Score = 110 bits (275), Expect = 5e-24
Identities = 84/249 (33%), Positives = 118/249 (47%), Gaps = 5/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTP-LHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA +G V LIN G + V R P LH+AA +LL+ + DV
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N + L++ G +++ ++G T LH AS G +LL+ GA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K K T LH A +N H + + +LL G+ K G + +H+AA+ +HL +RL
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + T LHVAA H +VAK+LL+ GA G TPL A N+
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 253 PEVALLLTK 261
V LL K
Sbjct: 384 VRVMELLLK 392
Score = 103 bits (256), Expect = 7e-22
Identities = 80/286 (27%), Positives = 132/286 (46%), Gaps = 32/286 (11%)
Query: 4 QDAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILL 62
++A AA S L AA G + + + G + ++G LHLA+ +GH+ +V LL
Sbjct: 8 READAATS--FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 63 KAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQ 122
L+ TALH A + G E++ L++ G ++ Q + G T L+ A+ +
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 123 SAKLLVKAGA----------------------NVLA-------KNKAGNTALHLACQNSH 153
K L++ GA NV+A K K ALH+A +N
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 185
Query: 154 SQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213
+++ VLL D+ + G T LH+AA Y +L++ +LLL SV+ Q G T LH+
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
A+ + + ++LL+ GA TPL A + + ++ +L
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 102 bits (255), Expect = 1e-21
Identities = 66/221 (29%), Positives = 113/221 (51%), Gaps = 4/221 (1%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA G+L L+ G D++ + LH A+ G+ +++ L+H+ L+ K G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH A+ G + + LV GANV A+++ G T L++A Q +H + + LL G+ +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
+ G T L VA + H +++ L+ + K + ALH+AA + + A +LL+
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 229 AGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ +++ G TPL A ++ N VA LL + F+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Score = 90.5 bits (223), Expect = 5e-18
Identities = 91/347 (26%), Positives = 149/347 (42%), Gaps = 18/347 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA + + V L+ +G + +G TPLH+AA + + V + LL+ G + +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E++A L+ + + +K G T LH + G A +L+K G
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V A + G T LH+A + + + LL + + K G + LH AA+ H I+ L
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV-------NNAGQTPLE 245
LL S +E + G T L +A L + V +L +T+ V + +T E
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 812
Query: 246 TARYHNNPEVALLLTKAPQVLRFSRGRSLRKKR----ERLKEERRAQSVPRDEVAQSKGS 301
+ L+ KA + R SR K+ +L + + ++PR A +
Sbjct: 813 ILDVSEDEGEELISFKAER--RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
Query: 302 VSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAF 348
V S EQ A KE + + +SP D+ + P + F
Sbjct: 871 V----IRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGF 913
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 137 bits (345), Expect = 3e-32
Identities = 87/247 (35%), Positives = 129/247 (52%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ G L++KGA+ + +G TPLH+A K H+ V+++LLK G +D
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ T LH A+ +G+ I+ L+ G + + + T LH A+ G ++ AK L++ A
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V AK K T LH A + H+ ++LL + +L AG T LH+AAR H+ +
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + G T LHVAA +VA++LLE A G TPL A +HNN
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
Query: 253 PEVALLL 259
++ LL
Sbjct: 582 LDIVKLL 588
Score = 127 bits (318), Expect = 5e-29
Identities = 84/244 (34%), Positives = 121/244 (49%), Gaps = 1/244 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + L+ GA + AVT+ G TPLH+A+ GHLP+V+ LL+ G +V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+T LH A G+TE+ L+ ++ + KD T LH A+ G + KLL++ A
Sbjct: 435 VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N AG+T LH+A + H ++ LL + G T LHVAA+Y + + L
Sbjct: 495 NPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G T LHVA N+ + K+LL G G TPL A N
Sbjct: 555 LLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 253 PEVA 256
EVA
Sbjct: 615 VEVA 618
Score = 120 bits (302), Expect = 3e-27
Identities = 83/258 (32%), Positives = 129/258 (50%), Gaps = 3/258 (1%)
Query: 17 AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
AA G L++ GA + A TK+G +P+H+AA HL V++LL+ ++D
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
T LH A G+ + L+ +G + + +G T LH A + +LL+K GA++
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
A ++G T LH+A H + LL G+ ++ N +T LH+AAR H + + LL
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Query: 196 AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE- 254
V+ K + T LH AA + H + K+LLE A+ + AG TPL A + E
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVET 518
Query: 255 -VALLLTKAPQVLRFSRG 271
+ALL +A Q +G
Sbjct: 519 VLALLEKEASQACMTKKG 536
Score = 120 bits (300), Expect = 6e-27
Identities = 83/250 (33%), Positives = 124/250 (49%), Gaps = 2/250 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA++ G V L+ +GA V+ TPLH+AA GH V + LL+ ++ +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
DQT LH A +G+T ++ L+ + G+T LH A+ G ++ L++ A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K G T LH+A + + +LL + + G T LHVA +N+L I++L
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKL 587
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S H G T LH+AA N +VA+ LL+ G + G TPL A +
Sbjct: 588 LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Query: 253 PE-VALLLTK 261
E VALLL+K
Sbjct: 648 AEMVALLLSK 657
Score = 119 bits (298), Expect = 1e-26
Identities = 82/248 (33%), Positives = 124/248 (50%), Gaps = 2/248 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A+ +G V L+++GA++ TK TPLH AA GH+ + +ILL G + +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ +H A + + + L+ +D D T LH A+ G + AK+L+ GA
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
++ G T LH+AC+ +H + +LL G+ D +G T LHVA+ HL I++
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE-TARYHN 251
LL S + N +T LH+AA H +VAK LL+ A QTPL AR +
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 252 NPEVALLL 259
V LLL
Sbjct: 483 TNMVKLLL 490
Score = 118 bits (296), Expect = 2e-26
Identities = 79/249 (31%), Positives = 124/249 (49%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA +G E V+ L+ K A A +TK G TPLH+AA G + V ++LL+ +
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N +I+ L+ G + +G T LH A+ + A+ L++ G
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A++ G T LHLA Q H++ +LL + +L N +G T LH+ A+ H+ + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L+ V + G T LHVA+ + K+ K LL+ AD G +PL A +
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 253 PEVALLLTK 261
++ LL K
Sbjct: 747 TDIVTLLLK 755
Score = 116 bits (291), Expect = 6e-26
Identities = 77/236 (32%), Positives = 114/236 (48%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G+ L+ + A A K+G TPLH+A + +L +V++LL G
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A E+ +L+ G + + + G T LH A+ G ++ LL+ A
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQA 659
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N NK+G T LHL Q H VL+ G D G T LHVA+ Y ++ +++
Sbjct: 660 NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF 719
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL V+ K + G + LH AA H + +LL+ GA V++ G TPL A+
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 114 bits (286), Expect = 2e-25
Identities = 81/249 (32%), Positives = 126/249 (50%), Gaps = 1/249 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA G TE L+ A+V A K +TPLH AA GH +V++LL+ + ++
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E + AL+ + + K G T LH A+ +G + A+LL++ A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A +++ ++LL G G T LH+AA+ N + + R
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S + ++ G T LH+AA H ++ +LL A+ + N +G TPL +
Sbjct: 621 LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGH 680
Query: 253 PEVALLLTK 261
VA +L K
Sbjct: 681 VPVADVLIK 689
Score = 110 bits (275), Expect = 5e-24
Identities = 84/249 (33%), Positives = 118/249 (47%), Gaps = 5/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTP-LHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA +G V LIN G + V R P LH+AA +LL+ + DV
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N + L++ G +++ ++G T LH AS G +LL+ GA
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ K K T LH A +N H + + +LL G+ K G + +H+AA+ +HL +RL
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + T LHVAA H +VAK+LL+ GA G TPL A N+
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383
Query: 253 PEVALLLTK 261
V LL K
Sbjct: 384 VRVMELLLK 392
Score = 103 bits (256), Expect = 7e-22
Identities = 80/286 (27%), Positives = 132/286 (46%), Gaps = 32/286 (11%)
Query: 4 QDAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILL 62
++A AA S L AA G + + + G + ++G LHLA+ +GH+ +V LL
Sbjct: 8 READAATS--FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 63 KAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQ 122
L+ TALH A + G E++ L++ G ++ Q + G T L+ A+ +
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 123 SAKLLVKAGA----------------------NVLA-------KNKAGNTALHLACQNSH 153
K L++ GA NV+A K K ALH+A +N
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 185
Query: 154 SQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213
+++ VLL D+ + G T LH+AA Y +L++ +LLL SV+ Q G T LH+
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Query: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
A+ + + ++LL+ GA TPL A + + ++ +L
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Score = 102 bits (255), Expect = 1e-21
Identities = 66/221 (29%), Positives = 113/221 (51%), Gaps = 4/221 (1%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA G+L L+ G D++ + LH A+ G+ +++ L+H+ L+ K G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH A+ G + + LV GANV A+++ G T L++A Q +H + + LL G+ +
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
+ G T L VA + H +++ L+ + K + ALH+AA + + A +LL+
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLI----NYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 229 AGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ +++ G TPL A ++ N VA LL + F+
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Score = 90.5 bits (223), Expect = 5e-18
Identities = 91/347 (26%), Positives = 149/347 (42%), Gaps = 18/347 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VA + + V L+ +G + +G TPLH+AA + + V + LL+ G + +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G+ E++A L+ + + +K G T LH + G A +L+K G
Sbjct: 633 VQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGV 692
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V A + G T LH+A + + + LL + + K G + LH AA+ H I+ L
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV-------NNAGQTPLE 245
LL S +E + G T L +A L + V +L +T+ V + +T E
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDE 812
Query: 246 TARYHNNPEVALLLTKAPQVLRFSRGRSLRKKR----ERLKEERRAQSVPRDEVAQSKGS 301
+ L+ KA + R SR K+ +L + + ++PR A +
Sbjct: 813 ILDVSEDEGEELISFKAER--RDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETV 870
Query: 302 VSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAF 348
V S EQ A KE + + +SP D+ + P + F
Sbjct: 871 V----IRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGF 913
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 133 bits (335), Expect = 5e-31
Identities = 83/247 (33%), Positives = 128/247 (51%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A K + + + L+ GA + AVT+ G TP+H+AA GH+ +V L+ G + +
Sbjct: 404 LHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTN 463
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+TALH A G E++ L+ +G ++ + KD T LH ++ G + + L++ GA
Sbjct: 464 VRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A +G T LHL+ + H LL G+ + G T LHVAA+Y L + L
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S ++G T LHVAA +++KVA +LL+ GA G TPL A N
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643
Query: 253 PEVALLL 259
++A L
Sbjct: 644 MDIATTL 650
Score = 133 bits (334), Expect = 7e-31
Identities = 83/247 (33%), Positives = 130/247 (52%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ G + L++K A A +G TPLH+A K + V+++LLK G +
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ T +H A +G+ I++ L+H G + + + G TALH A+ G ++ + LV+ GA
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA 490
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V AK K T LH++ + + + LL G+ + +G T LH++AR H +
Sbjct: 491 QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF 550
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S+ + G T LHVAA +VA +LL+ A +G TPL A +++N
Sbjct: 551 LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN 610
Query: 253 PEVALLL 259
+VALLL
Sbjct: 611 QKVALLL 617
Score = 127 bits (320), Expect = 3e-29
Identities = 96/323 (29%), Positives = 145/323 (44%), Gaps = 4/323 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA K T+ L+ V +K G TPLH+AA+ G++ V +LL +D
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
D T LH A+ GN ++ L+ G +D + +DG T LH + G Q ++L+ A
Sbjct: 266 RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+L+K K G + LH+A Q H ++LL D N T LHVAA H + ++
Sbjct: 326 PILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKV 385
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARY--H 250
LL + + K G T LH+A N KV ++LL+ GA V +G TP+ A + H
Sbjct: 386 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGH 445
Query: 251 NNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSS 310
N L+ A RG + R + + + +D AQ + TP
Sbjct: 446 VNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG-AQVEAKAKDDQTPLH 504
Query: 311 EQAVARKEEAREEFLSASPEPRA 333
A K + ++ L P A
Sbjct: 505 ISARLGKADIVQQLLQQGASPNA 527
Score = 126 bits (316), Expect = 8e-29
Identities = 80/245 (32%), Positives = 119/245 (48%), Gaps = 1/245 (0%)
Query: 16 VAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG 74
VAA+ G V QL++ GA T G T LH+AA G VV+ L++ G ++ +
Sbjct: 439 VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
DQT LH + +G +I+ L+ +G + + G T LH ++ G A L+ GA++
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558
Query: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
K G T LH+A + + +LL + D +G T LHVAA Y++ + LLL
Sbjct: 559 SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLL 618
Query: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
S H + G T LH+AA N +A LLE GAD V G + A + +
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
Query: 255 VALLL 259
+ LL
Sbjct: 679 MVSLL 683
Score = 124 bits (312), Expect = 2e-28
Identities = 81/247 (32%), Positives = 123/247 (49%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L ++A G+ + V QL+ +GA A T G TPLHL+A +GH V LL G L +
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A G E+ L+ + + D K G T LH A+ + + A LL+ GA
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K G T LH+A + + LL G+ A+ G +H+AA+ H+ ++ L
Sbjct: 623 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSL 682
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL +V+ N++G T LH+AA + VA++L+ GA G TPL ++ N
Sbjct: 683 LLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGN 742
Query: 253 PEVALLL 259
++ L
Sbjct: 743 IKIVNFL 749
Score = 118 bits (296), Expect = 2e-26
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA GQ E V L+ GA+V A K +TPLH++A G +VQ LL+ G +
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH + G+ ++ A L+ G +L K G T LH A+ +G + A LL++ A
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A K+G T LH+A + + +LL G+ G T LH+AA+ N + I
Sbjct: 590 SPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATT 649
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + G ++H+AA H + +LL A+ + N +G TPL A +
Sbjct: 650 LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDR 709
Query: 253 PEVALLL 259
VA +L
Sbjct: 710 VNVAEVL 716
Score = 115 bits (287), Expect = 2e-25
Identities = 74/221 (33%), Positives = 114/221 (51%), Gaps = 4/221 (1%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108
AA GHL +K G D+++ + ALH A+ G+ E+++ L+ +D K G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
NTALH AS G ++ K+LV GANV A+++ G T L++A Q +H + + LL G+
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167
Query: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE 228
L G T L VA + H ++ LLL K + ALH+AA + K A +LL+
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
Query: 229 AGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
+ + + +G TPL A ++ N VA LL + F+
Sbjct: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Score = 110 bits (276), Expect = 4e-24
Identities = 79/283 (27%), Positives = 132/283 (46%), Gaps = 31/283 (10%)
Query: 15 LVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
L AA G E + I G + + ++G LHLA+ +GH+ VV LL+ ++D
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
TALH A++ G E++ L+ G ++ Q ++G T L+ A+ + K L+ GA+
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165
Query: 134 VLAKNKAGNT-----------------------------ALHLACQNSHSQSTRVLLLAG 164
+ G T ALH+A + +++ +LL
Sbjct: 166 QSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQND 225
Query: 165 SRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224
+ AD+++ +G T LH+AA Y ++++ LLL +V + T LHVA+ + + K
Sbjct: 226 NNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVK 285
Query: 225 ILLEAGADTTIVNNAGQTPLET-ARYHNNPEVALLLTKAPQVL 266
+LL+ GA G TPL AR + V +LL +A +L
Sbjct: 286 LLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Score = 110 bits (275), Expect = 5e-24
Identities = 72/243 (29%), Positives = 120/243 (49%), Gaps = 1/243 (0%)
Query: 18 AYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQ 76
A G + V L+++ A + + TK+G +PLH+A HL VQ+LL+ +D +
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL 368
Query: 77 TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLA 136
TALH A G+ ++ L+ + + + +G T LH A + +LL+K GA++ A
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 137 KNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTA 196
++G T +H+A H L+ G+ + N G+T LH+AAR ++R L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 197 FCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVA 256
V K + T LH++A L + + LL+ GA +G TPL + + +VA
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548
Query: 257 LLL 259
L
Sbjct: 549 AFL 551
Score = 110 bits (274), Expect = 6e-24
Identities = 72/247 (29%), Positives = 117/247 (47%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L ++A +G + L++ GA +++T K G TPLH+AA G L V +LL+ D
Sbjct: 536 LHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG 595
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A N ++ L+ +G + K+G T LH A+ A L++ GA
Sbjct: 596 KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A + G ++HLA Q H +LL + +L N +G T LH+AA+ + +++ +
Sbjct: 656 DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEV 715
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L+ V + + G T LHV + K+ LL+ A G TPL A +
Sbjct: 716 LVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGH 775
Query: 253 PEVALLL 259
+ +L
Sbjct: 776 THIINVL 782
Score = 110 bits (274), Expect = 6e-24
Identities = 77/236 (32%), Positives = 104/236 (44%), Gaps = 1/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G+ E L+ K A A K G TPLH+AA+ + V +LL G
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A +I L+ G + + G ++H A+ G LL+ A
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
NV NK+G T LHLA Q VL+ G+ D + G T LHV Y ++ I+
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
LL V+ K + G T LH AA H + +LL+ A + G T L AR
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR 804
Score = 105 bits (262), Expect = 1e-22
Identities = 73/227 (32%), Positives = 114/227 (50%), Gaps = 4/227 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ + + L+++GA A K+G TPLH+AA K + + LL+ G D +
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
++H A G+ ++++ L+ ++ +K G T LH A+ A++LV GA
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+V A+ K G T LH+ C + + LL ++ + K G T LH AA+ H II +
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVA---KILLEAGADTTIV 236
LL S +E G+TAL +A L + V KI+ E TT V
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTV 828
Score = 99.4 bits (246), Expect = 1e-20
Identities = 81/276 (29%), Positives = 124/276 (44%), Gaps = 30/276 (10%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCD----- 67
L +A+ GQ E V L+ GA V A +++G TPL++AA + HL VV+ LL G
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLAT 170
Query: 68 --------LDVQDDGDQT----------------ALHRATVVGNTEIIAALIHEGCALDR 103
+ +Q DQ ALH A +T+ A L+ D
Sbjct: 171 EDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV 230
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLA 163
+ K G T LH A+ +G A LL+ A V + T LH+A + ++ ++LL
Sbjct: 231 ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR 290
Query: 164 GSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVA 223
G++ D K G T LH AR H ++ +LL + K + G + LH+A +H
Sbjct: 291 GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCV 350
Query: 224 KILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
++LL+ V N T L A + + +VA +L
Sbjct: 351 QLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Score = 84.7 bits (208), Expect = 3e-16
Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 1/165 (0%)
Query: 96 HEGCALDRQDK-DGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHS 154
H + DR+ K D N + A+ G + A +K G ++ N+ G ALHLA + H
Sbjct: 28 HRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHV 87
Query: 155 QSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVA 214
+ LL + D G+T LH+A+ ++++L+T +V+ ++Q G T L++A
Sbjct: 88 EVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA 147
Query: 215 AALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
A NH +V K LL+ GA ++ G TPL A + +V LL
Sbjct: 148 AQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Score = 32.3 bits (72), Expect = 1.6
Identities = 46/213 (21%), Positives = 78/213 (36%), Gaps = 9/213 (4%)
Query: 119 GFSQSAKLLVKAGA--NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT 176
G Q +KL +KA + + N NT Q S S+ T+ L + S D+K+
Sbjct: 3858 GIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKALTTS-SCVDVKSRIPVK 3916
Query: 177 CLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV 236
H R N +++ + T EK +A + + V A TT
Sbjct: 3917 NTH---RDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTT 3973
Query: 237 NNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVA 296
+ R EV + + + G +L+ +EE++ QS DE
Sbjct: 3974 TTTTTSCTVKVRKSQLKEVC---KHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEE 4030
Query: 297 QSKGSVSAGDTPSSEQAVARKEEAREEFLSASP 329
+ + S +T Q + AR++ A+P
Sbjct: 4031 STSRNTSLSETSRGGQPSVTTKSARDKKTEAAP 4063
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 129 bits (324), Expect = 1e-29
Identities = 86/254 (33%), Positives = 135/254 (53%), Gaps = 2/254 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L+ A YKG+T+ V L++ GA +VT + P+ AA +GH +V +LL+ G ++ D
Sbjct: 108 LMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSD 167
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T L A G+ E + L+ G +D++ + TAL A G++QS K ++K
Sbjct: 168 KYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNP 227
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
NV +K GNTAL +A + H++ + LL AG+ ++ + +GDT L A R H+ I+R
Sbjct: 228 NVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRA 287
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL + + + Q TAL+ A + + + +L+ DT I G+TPL A N
Sbjct: 288 LLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRN 347
Query: 253 PEVA-LLLTKAPQV 265
EV LLL K +V
Sbjct: 348 IEVVELLLDKGAKV 361
Score = 115 bits (287), Expect = 2e-25
Identities = 79/252 (31%), Positives = 130/252 (51%), Gaps = 1/252 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
++ AA +G + V L+ GA+V + K+G TPL AA KGHL V+ LL G D+D +
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
TAL A G T+ + ++ ++ DKDGNTAL AS G ++ + L+ AG
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V +++G+T L A + H + R LL + D++ T L+ A + +++R
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
+L + G+T L A + + +V ++LL+ GA + V+ G TPL A +
Sbjct: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
Query: 253 PEVALLLTKAPQ 264
++A LL + P+
Sbjct: 381 RKLAELLLRNPK 392
Score = 90.1 bits (222), Expect = 6e-18
Identities = 62/214 (28%), Positives = 104/214 (48%)
Query: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101
G+TPL +AA +G+L +V+ L+K G + +++D + TAL A+ G+ I+ L+ G L
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 97
Query: 102 DRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLL 161
+ +D G TAL A + G + +LL+ GAN + A H+ +LL
Sbjct: 98 EHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLL 157
Query: 162 LAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKK 221
G++ + + G T L AAR HL ++ LL V ++ TAL VA + +
Sbjct: 158 QNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQ 217
Query: 222 VAKILLEAGADTTIVNNAGQTPLETARYHNNPEV 255
K +L+ + + + G T L A + E+
Sbjct: 218 SVKEILKRNPNVNLTDKDGNTALMIASKEGHTEI 251
Score = 76.6 bits (187), Expect = 7e-14
Identities = 57/179 (31%), Positives = 84/179 (46%)
Query: 54 HLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALH 113
++P ++ LL+ D+D +++ QT L A GN EI+ LI G + +D D TAL
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 114 EASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA 173
AS G + L+K G N+ ++ G TAL AC + +LL G+ +
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 174 GDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
+ AA H I+ LLL V+ ++ G T L AA H + K LL GAD
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Score = 62.4 bits (150), Expect = 1e-09
Identities = 44/150 (29%), Positives = 76/150 (50%), Gaps = 4/150 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L+ A G E V L+ K A + + + +T L+ A KG+ +V+ +L+ D ++
Sbjct: 273 LIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICT 332
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLV---K 129
+T L +AT + N E++ L+ +G + DK G+T LH A + A+LL+ K
Sbjct: 333 KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPK 392
Query: 130 AGANVLAKNKAGNTALHLACQNSHSQSTRV 159
G + NKAG T ++ C + S T++
Sbjct: 393 DGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/135 (23%), Positives = 64/135 (47%)
Query: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
K L++ +V +N+ G T L +A + + + + L+ G+ +L++ T L A++
Sbjct: 22 KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL 244
H+ I+ LL ++ ++ G TAL A V ++LL GA+ ++ P+
Sbjct: 82 GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
Query: 245 ETARYHNNPEVALLL 259
A + ++ LL
Sbjct: 142 IWAAGRGHADIVHLL 156
Score = 30.8 bits (68), Expect = 4.6
Identities = 19/76 (25%), Positives = 37/76 (48%)
Query: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
++ ++ LL V E+N+ G T L +AA + ++ K L++ GA+ + + T L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 246 TARYHNNPEVALLLTK 261
+A + + L K
Sbjct: 77 SASKEGHVHIVEELLK 92
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 129 bits (323), Expect = 1e-29
Identities = 80/235 (34%), Positives = 120/235 (51%), Gaps = 1/235 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
LL+AA G + + LI +G+R+ V K G ++ AA GH+ ++ L + C LDV+D
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ ALH A G+ ++ L G + QDK+ T LH A+WHG+ AK L +AG
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGC 502
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
NV KN+ G T L A + L G+ + + G LH+A R + +I+
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKT 562
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
LL+ C V +++ G+T LHVA + + L EA + I N G+TPL A
Sbjct: 563 LLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Score = 104 bits (259), Expect = 3e-22
Identities = 72/221 (32%), Positives = 108/221 (48%), Gaps = 1/221 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G + L + G+ + K TPLH AA G+ V + L +AGC++++++
Sbjct: 449 LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+T L A+ G +I+ L G L+ DKDG+ ALH A + K L+ G
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGC 568
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V +++ GNT LH+AC++ + L A D+ N G T LH+AA L ++R
Sbjct: 569 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 628
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADT 233
L SV G TA +A + H+ VA +L DT
Sbjct: 629 LCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDT 669
Score = 86.3 bits (212), Expect = 9e-17
Identities = 59/191 (30%), Positives = 95/191 (49%), Gaps = 8/191 (4%)
Query: 69 DVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQD-----KDGNTALHEASWHGFSQS 123
D D+ D + N + + L H +L D K G L A+ G Q
Sbjct: 335 DTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQI 394
Query: 124 AKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAAR 183
+LL+K G+ + ++K G+ A++ A ++ H + + L D+K+ +G+ LHVAAR
Sbjct: 395 LQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAAR 454
Query: 184 YNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTP 243
Y H + +LL + + + +++ +T LH AA + VAK L EAG + I N G+TP
Sbjct: 455 YGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETP 514
Query: 244 LETAR---YHN 251
L TA YH+
Sbjct: 515 LLTASARGYHD 525
Score = 75.1 bits (183), Expect = 2e-13
Identities = 41/125 (32%), Positives = 68/125 (54%)
Query: 138 NKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAF 197
NK G L +A + Q ++L+ GSR D+++ G ++ AAR+ H+ ++ L
Sbjct: 376 NKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENK 435
Query: 198 CSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVAL 257
C + K+++G+ ALHVAA H VA++L G++ I + +TPL A +H VA
Sbjct: 436 CPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAK 495
Query: 258 LLTKA 262
L +A
Sbjct: 496 ALCEA 500
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 127 bits (320), Expect = 3e-29
Identities = 93/290 (32%), Positives = 136/290 (46%), Gaps = 3/290 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPV-VQILLKAGCDLDVQ 71
L +A Y GQ V +LI+ GA V +G TPLH AA H + +++L+ G D+++Q
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ LH V G LI G +D DKDGNT LH A+ +G L +G
Sbjct: 278 SKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG 337
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A+ LHLA N+HS R LL +G D + G TCLH AA ++ I+
Sbjct: 338 ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIK 397
Query: 192 LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHN 251
LL ++ H+K++ G T LH AAA H + L+ GA+ ++ G+T L A +
Sbjct: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
Query: 252 NPEVALLLTKA-PQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 300
+L A R R L++K L E Q+ + +G
Sbjct: 458 MDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEG 507
Score = 119 bits (297), Expect = 1e-26
Identities = 78/236 (33%), Positives = 120/236 (50%), Gaps = 3/236 (1%)
Query: 18 AYKGQTENVVQ-LINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
A ++E VQ LI A V A K+ +TPLH+AA + ++++ ++V D G
Sbjct: 56 AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
+TALH A + G+ E++ L+ +G ++ DK ALH A++ G LL+ GA V
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
K+K G T LH A N + LL G D N G+T LH+A +++ L+
Sbjct: 176 CKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID 235
Query: 196 AFCSVHEKNQAGDTALHVAAALNHKKVA-KILLEAGADTTIVNNAGQTPLETARYH 250
+V++ N G T LH AAA H + ++L+ GAD I + G++PL H
Sbjct: 236 YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVH 291
Score = 118 bits (295), Expect = 2e-26
Identities = 80/235 (34%), Positives = 114/235 (48%), Gaps = 1/235 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA+ G E + LI GARV A TPLH A VQ+L+K D++ +D
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 79
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
QT LH A + +I +++ D+ G TALH A+ +G + LL+ GA
Sbjct: 80 KNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGA 139
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N+ A +K ALH A H +L+ G+ K+ G T LH AA +++++
Sbjct: 140 NINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKH 199
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
LL + E N G+TALH+A V L++ GA+ NN G TPL A
Sbjct: 200 LLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254
Score = 109 bits (273), Expect = 8e-24
Identities = 66/213 (30%), Positives = 108/213 (50%)
Query: 43 RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD 102
RTPLH+AA G ++++L+ +G ++ +D+ T LHRA + E + LI ++
Sbjct: 17 RTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVN 76
Query: 103 RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLL 162
+DK+ T LH A+ + + A++++ ++V ++ G TALH A N H + +LL
Sbjct: 77 ARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLA 136
Query: 163 AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV 222
G+ + + LH AA HL ++ LL+ V K++ G T LH AA+ V
Sbjct: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196
Query: 223 AKILLEAGADTTIVNNAGQTPLETARYHNNPEV 255
K LL G + +N G T L A Y+ V
Sbjct: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229
Score = 103 bits (258), Expect = 4e-22
Identities = 75/236 (31%), Positives = 117/236 (49%), Gaps = 7/236 (2%)
Query: 24 ENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRAT 83
E +++ N G + + ++PLHLAA GH +++LL++ DLD++D+ +TAL A
Sbjct: 524 ELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAA 583
Query: 84 VVGNTEIIAALIHEGCALDRQDK-DGNTALHEASWHGFSQSAKLLVKAGAN---VLAKNK 139
G+TE + ALI+ G ++ +D T LH + +G + +LL++ N V K+
Sbjct: 584 FKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDA 643
Query: 140 AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCS 199
G T L LA H + +LL + D + G T LH H +++LL S
Sbjct: 644 KGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
Query: 200 VHEKNQAGDTALHVAAALNHKKVAKILLE---AGADTTIVNNAGQTPLETARYHNN 252
+ K+ G T LH AAA H LL+ + D +N G TPL A Y+ N
Sbjct: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGN 759
Score = 103 bits (257), Expect = 6e-22
Identities = 84/259 (32%), Positives = 132/259 (50%), Gaps = 17/259 (6%)
Query: 16 VAAYKGQTENVVQLINKGARVAVTKH--GRTPLHLAANKGHLPVVQILLKAGCD---LDV 70
+AA+KG TE V LIN GA + V + RTPLH + GH +++LL+ + +DV
Sbjct: 581 LAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDV 640
Query: 71 QDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKA 130
+D QT L A G+ + ++ L+ + +D D G TALH G + ++L++
Sbjct: 641 KDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQ 700
Query: 131 GANVLAKNKAGNTALHLACQNSHSQ-STRVLLLAGSRAD--LKNNAGDTCLHVAARYNHL 187
++L K+ G T LH A H+ + +L +A S D K+N G T LH A +
Sbjct: 701 EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760
Query: 188 SIIRLLLTAFCSVHEKNQAGD--TALHVAAALNHKKVAKILLEAGADTTIV---NNAGQT 242
+ I +LL C + G+ T LH A +H A +LL A D++IV ++ G+T
Sbjct: 761 NCIEVLLEQKCF---RKFIGNPFTPLHCAIINDHGNCASLLLGA-IDSSIVSCRDDKGRT 816
Query: 243 PLETARYHNNPEVALLLTK 261
PL A + ++ E LL +
Sbjct: 817 PLRAAAFADHVECLQLLLR 835
Score = 102 bits (254), Expect = 1e-21
Identities = 83/272 (30%), Positives = 117/272 (43%), Gaps = 31/272 (11%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAA G + L GA A H PLHLAA H + LL +G ++D D
Sbjct: 318 LHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPD 377
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+T LH A GN E I L G ++DK G T LH A+ + + LV GA
Sbjct: 378 KFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGA 437
Query: 133 NVLAKNKAGNTALHLACQ-----------NSHSQSTRV-----------------LLLAG 164
NV + G TALH A N+H S + LL
Sbjct: 438 NVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQND 497
Query: 165 SRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTA--LHVAAALNHKKV 222
+ +++ G +H AA Y H + LLL S E++ +G T LH+AA H +
Sbjct: 498 ANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQA 557
Query: 223 AKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
++LL++ D I + G+T L+ A + + E
Sbjct: 558 LEVLLQSLVDLDIRDEKGRTALDLAAFKGHTE 589
Score = 95.9 bits (237), Expect = 1e-19
Identities = 57/181 (31%), Positives = 93/181 (51%)
Query: 67 DLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKL 126
D++ D +T LH A +G+ EII LI G ++ +D T LH A ++ ++
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 127 LVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNH 186
L+K A+V A++K T LH+A N + V++ S ++ + G T LH AA H
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 187 LSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLET 246
+ ++ LLL +++ ++ ALH AA + H V +L+ GA+ T + G TPL
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187
Query: 247 A 247
A
Sbjct: 188 A 188
Score = 75.1 bits (183), Expect = 2e-13
Identities = 48/166 (28%), Positives = 84/166 (50%)
Query: 94 LIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSH 153
LIH+ ++ D + T LH A++ G ++ +LL+ +GA V AK+ T LH A +
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 154 SQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213
++ +VL+ + + ++ T LHVAA + +++ SV+ ++ G TALH
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121
Query: 214 AAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
AA H ++ +LL GA+ + + L A Y + +V LL
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Score = 55.8 bits (133), Expect = 1e-07
Identities = 38/146 (26%), Positives = 71/146 (48%), Gaps = 1/146 (0%)
Query: 126 LLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYN 185
+L+ +V + T LH+A ++ +L+L+G+R + K+N T LH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
+++L+ V+ +++ T LHVAAA K A++++ + + + G+T L
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 246 TARYHNNPE-VALLLTKAPQVLRFSR 270
A + + E V LLL K + F +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDK 146
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 1/88 (1%)
Query: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA- 100
GRTPL AA H+ +Q+LL+ ++ D+ +TAL A G + L++ A
Sbjct: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 873
Query: 101 LDRQDKDGNTALHEASWHGFSQSAKLLV 128
L +DKD NT LH A G + A L++
Sbjct: 874 LTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 123 bits (309), Expect = 5e-28
Identities = 77/257 (29%), Positives = 134/257 (52%), Gaps = 4/257 (1%)
Query: 12 ERLLVAAYKGQTENVVQLINKGARVAVT---KHGRTPLHLAANKGHLPVVQILLKAGCDL 68
++L +A +G+ + V+ ++ G ++ R+PLH AA GH+ + +L++AG ++
Sbjct: 740 KQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI 799
Query: 69 DVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLV 128
D + +T L A + E + LI G +D +D +G+T LH A+ G + + L+
Sbjct: 800 DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLL 859
Query: 129 KAGA-NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHL 187
G +V ++ G T + A + H ++LL GS ++++N + CLH AA +
Sbjct: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCV 919
Query: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
I +LL A C +H N GD+ LH+AA N + L +D T+ N G+TPL+ A
Sbjct: 920 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
Query: 248 RYHNNPEVALLLTKAPQ 264
++ AL ++KA Q
Sbjct: 980 SLNSQVWSALQMSKALQ 996
Score = 38.9 bits (89), Expect = 0.017
Identities = 32/123 (26%), Positives = 54/123 (43%), Gaps = 2/123 (1%)
Query: 145 LHLACQNSHSQSTRVLLLAGSRADLKNNAGD--TCLHVAARYNHLSIIRLLLTAFCSVHE 202
L+ + + Q ++L+ G + K + + LH AA H+ I +L+ A ++
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
Query: 203 KNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 262
++ T L AA NH + K L++AGA + G T L A + EV L
Sbjct: 802 CSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSN 861
Query: 263 PQV 265
Q+
Sbjct: 862 GQM 864
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 122 bits (307), Expect = 9e-28
Identities = 101/387 (26%), Positives = 168/387 (43%), Gaps = 20/387 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +AA++G LI +GAR + GR P LA+ +GH VQILL+ ++D +
Sbjct: 851 LHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRG 910
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+ AL A + G+ +I+ L G ++ +D DG L+ + A+ ++ GA
Sbjct: 911 YDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGA 970
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
NV A + G TALH++C H + +VL+ + + +N + L AA H+ +++L
Sbjct: 971 NVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 1030
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L+ V G TAL +AA H V ++LLE GAD + G+T + A + +
Sbjct: 1031 LIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGH 1090
Query: 253 PEVALLLTK-APQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSE 311
++ LL K L + ++ + ++ + S GS GD S
Sbjct: 1091 SQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSL 1150
Query: 312 QAVARKEEAREEFLSASPEPRAKDDRRRKS--------------RPKVSAFSDPTPPAD- 356
+ + F S S P + DR++ S R S + T P D
Sbjct: 1151 RGL--PNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDS 1208
Query: 357 -QQPGHQKNLHAHNHPKKRNRHRCSSP 382
+ + H+ P+ R+R SP
Sbjct: 1209 FHNLSFTEQIQQHSLPRSRSRQSIVSP 1235
Score = 118 bits (295), Expect = 2e-26
Identities = 78/252 (30%), Positives = 125/252 (49%), Gaps = 6/252 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L AA+ G + V+ L+ GA V GRT L AA GH +V+ LL G +++ +D
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
Query: 73 DGDQTALHRATVV-----GNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLL 127
+TAL A + G+ +++ LI G +D DKDG T L A++ G LL
Sbjct: 708 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
Query: 128 VKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHL 187
++ GA+V + G T L A H+ LL G+ D ++ G T L +A+ ++
Sbjct: 768 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNV 827
Query: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
++R LL + ++ AG T LH+AA H+ + + L+E GA T ++N G+ P A
Sbjct: 828 EVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 887
Query: 248 RYHNNPEVALLL 259
+ + +L
Sbjct: 888 SQEGHYDCVQIL 899
Score = 117 bits (292), Expect = 5e-26
Identities = 80/242 (33%), Positives = 118/242 (48%), Gaps = 6/242 (2%)
Query: 24 ENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRA 82
+++ L++ GA V +GRT L AA G L VV +L+ G DL+++D T L A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 83 TVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGN 142
G+T+++ LI G ++ D+DG TAL A+W G ++ L+ AG V +
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR 645
Query: 143 TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHE 202
TAL A H LL G+ + +N G T L AA H I+ LL V+
Sbjct: 646 TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNH 705
Query: 203 KNQAGDTALHVA-----AALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVAL 257
++ G TAL VA A+ H V +L++ GA+ + G TPL A Y + +V
Sbjct: 706 EDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD 765
Query: 258 LL 259
LL
Sbjct: 766 LL 767
Score = 116 bits (291), Expect = 6e-26
Identities = 80/254 (31%), Positives = 125/254 (49%), Gaps = 2/254 (0%)
Query: 5 DAVAALS-ERLLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILL 62
D ALS L V A KG V LI++GA V K G TPL +AA +GH+ VV +LL
Sbjct: 709 DGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL 768
Query: 63 KAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQ 122
+ G D+D D+ +T L A +G+ ++ L+ G A+D D +G T L AS G +
Sbjct: 769 EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE 828
Query: 123 SAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAA 182
+ L+ G + ++ AG T LH+A H L+ G+R + +N G +A+
Sbjct: 829 VVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILAS 888
Query: 183 RYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQT 242
+ H +++LL ++ ++ G AL VAA H+ + ++L GAD + G+
Sbjct: 889 QEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
Query: 243 PLETARYHNNPEVA 256
L N +A
Sbjct: 949 TLYILALENQLTMA 962
Score = 115 bits (289), Expect = 1e-25
Identities = 81/247 (32%), Positives = 119/247 (48%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
LLVAAY+G + V L+ GA V T +GRTPL AA+ GH VV LL G +D D
Sbjct: 752 LLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSID 811
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
+T L A+ GN E++ L+ G + +D G T LH A++ G + L++ GA
Sbjct: 812 SEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA 871
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ G LA Q H ++LL S D + G L VAA H I+ L
Sbjct: 872 RTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL 931
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L + V+ K+ G L++ A N +A+ LE GA+ + G+T L + + +
Sbjct: 932 LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGH 991
Query: 253 PEVALLL 259
E+ +L
Sbjct: 992 MEMVQVL 998
Score = 108 bits (269), Expect = 2e-23
Identities = 73/247 (29%), Positives = 119/247 (48%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
LL AA G V L+ GA V ++ GRT L +A+ +G++ VV+ LL G D + +D
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
D T LH A G+ I ALI +G + D DG AS G ++L++ +
Sbjct: 845 DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS 904
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N+ + G AL +A H +L G+ + K+ G L++ A N L++
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L +V + G TALHV+ H ++ ++L+ AD +N ++ L++A + +
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH 1024
Query: 253 PEVALLL 259
+V LL
Sbjct: 1025 VKVVQLL 1031
Score = 87.0 bits (214), Expect = 5e-17
Identities = 58/199 (29%), Positives = 99/199 (49%), Gaps = 2/199 (1%)
Query: 57 VVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEAS 116
V+Q+L+KAG ++ +DD + +A + + I L+ G ++++ D +G T L A+
Sbjct: 496 VLQLLVKAGAHVNSEDDRTSCIVRQA--LEREDSIRTLLDNGASVNQCDSNGRTLLANAA 553
Query: 117 WHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT 176
+ G LLV GA++ ++ G+T L LA + H++ L+ G+ + + G T
Sbjct: 554 YSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWT 613
Query: 177 CLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIV 236
L AA H ++ LL A V + TAL AA H+ + LL+ GA+
Sbjct: 614 ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673
Query: 237 NNAGQTPLETARYHNNPEV 255
+N G+T L A Y + E+
Sbjct: 674 DNEGRTALIAAAYMGHREI 692
Score = 53.5 bits (127), Expect = 7e-07
Identities = 41/138 (29%), Positives = 67/138 (48%), Gaps = 2/138 (1%)
Query: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
+LLVKAGA+V +++ + + A + S R LL G+ + ++ G T L AA
Sbjct: 498 QLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANAAYS 555
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL 244
L ++ LL++ + ++ G T L +AA H KV L+ GA+ + G T L
Sbjct: 556 GSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTAL 615
Query: 245 ETARYHNNPEVALLLTKA 262
+A + + EV L A
Sbjct: 616 RSAAWGGHTEVVSALLYA 633
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 120 bits (301), Expect = 4e-27
Identities = 87/265 (32%), Positives = 130/265 (49%), Gaps = 15/265 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKH-GRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L+VAAY G + V +L+ +GA + + + G T L AA +GH VV+ L G + +
Sbjct: 50 LMVAAYAGHIDCVRELVLQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRT 109
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
TAL A+ G+ +++ L+ G + Q DG TAL A+ G+ +LL+ +GA
Sbjct: 110 KDGGTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
V + G L +A Q HS+ RV+LL G+ D N G T L AA + +I+
Sbjct: 170 KVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKE 229
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL F + G +ALH A + K +LLEAGAD ++ N A + P E
Sbjct: 230 LLK-FSPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAE------- 281
Query: 253 PEVALLLTKAPQVLRFSRGRSLRKK 277
LTK ++LR R + +K
Sbjct: 282 ------LTKNERILRLLRSKEGPRK 300
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 119 bits (298), Expect = 1e-26
Identities = 83/246 (33%), Positives = 126/246 (51%), Gaps = 4/246 (1%)
Query: 17 AAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
AAY G E V L++ GA V K TPLH AA+ G + VV+ LL G D++ +
Sbjct: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALH--EASWHGFSQSAKLLVKAGAN 133
T LH A G ++ LI G ++++++ G T LH AS HG + +LLV GA+
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG-ALCLELLVGNGAD 298
Query: 134 VLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL 193
V K+K G T LH+ + ++ ++ +G+ D ++ G+T LH+AARY H +I L
Sbjct: 299 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Query: 194 LTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNP 253
+T+ ++ G LH+AA + LL +G D ++ G+T L A N
Sbjct: 359 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 418
Query: 254 EVALLL 259
E LL
Sbjct: 419 ECLNLL 424
Score = 119 bits (297), Expect = 1e-26
Identities = 81/235 (34%), Positives = 113/235 (48%), Gaps = 1/235 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L AAY G E + LI GARV A TPLH A VQ+LLK D++ +D
Sbjct: 45 LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD 104
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
QT LH A + AL+ ++ D+ G TALH A++ G + KLL+ GA
Sbjct: 105 KNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGA 164
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
N+ A +K A+H A H + ++L+ G+ K+ T LH AA +S+++
Sbjct: 165 NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKY 224
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
LL ++E N G+T LHVA V L++ GA N G TPL A
Sbjct: 225 LLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
Score = 116 bits (291), Expect = 6e-26
Identities = 79/236 (33%), Positives = 120/236 (50%), Gaps = 2/236 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPV-VQILLKAGCDLDVQ 71
L VA Y GQ V +LI+ GA V + G TPLH AA H + +++L+ G D++++
Sbjct: 243 LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMK 302
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+T LH + G +I G +D +DK+GNT LH A+ +G L+ +G
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A+ + G LHLA + S R LL +G D ++ G TCLH AA +L +
Sbjct: 363 ADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLN 422
Query: 192 LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
LLL ++K++ G + LH AAA + + L+ +GA ++ G TPL A
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478
Score = 115 bits (287), Expect = 2e-25
Identities = 75/243 (30%), Positives = 121/243 (49%), Gaps = 1/243 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHG-RTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L+ A + G + V LI K V + RTPLH AA G ++++L+ +G ++ +D
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LHRA + E + L+ ++ +DK+ T LH A+ + + A+ LV +
Sbjct: 72 SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLS 131
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
NV ++AG TALH A + H + ++LL G+ + + +H AA H+ +++L
Sbjct: 132 NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L++ V K++ T LH AA+ V K LL+ G D N G TPL A Y+
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ 251
Query: 253 PEV 255
V
Sbjct: 252 DVV 254
Score = 111 bits (277), Expect = 3e-24
Identities = 84/290 (28%), Positives = 133/290 (45%), Gaps = 43/290 (14%)
Query: 16 VAAYKGQTENVVQLINKGARVAVTKH--GRTPLHLAANKGHLPVVQILL---KAGCDLDV 70
+AA+KG E V LIN+GA + V + RTP+H AA GH +++L+ + +D+
Sbjct: 589 LAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDI 648
Query: 71 QDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKA 130
QD QT L + + G+T+ + +L+++G +D +DK G TALH + G + L++
Sbjct: 649 QDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQH 708
Query: 131 GANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLK----NNAGDTCLHVAARYNH 186
GA L ++ G T +HL+ H LL + + D +N G T LH A H
Sbjct: 709 GAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGH 768
Query: 187 LSIIRLLL----------TAF----CSVHEKNQA--------------------GDTALH 212
+ + LLL AF C+V N+ G T LH
Sbjct: 769 ETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLH 828
Query: 213 VAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 262
AA +H + ++LL A V++ G+TPL A + +L +
Sbjct: 829 AAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS 878
Score = 110 bits (276), Expect = 4e-24
Identities = 75/229 (32%), Positives = 114/229 (49%), Gaps = 2/229 (0%)
Query: 24 ENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRA 82
E V L+ A V A K+ +TPLH+AA + + L+ +++V D +TALH A
Sbjct: 88 EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
Query: 83 TVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGN 142
G+ E++ L+ G ++ DK A+H A++ G + KLLV GA V K+K
Sbjct: 148 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSY 207
Query: 143 TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHE 202
T LH A + + LL G + N G+T LHVA ++ L+ V++
Sbjct: 208 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQ 267
Query: 203 KNQAGDTALHVAAALNHKKVA-KILLEAGADTTIVNNAGQTPLETARYH 250
KN+ G T LH AAA H + ++L+ GAD + + G+TPL H
Sbjct: 268 KNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316
Score = 107 bits (266), Expect = 5e-23
Identities = 86/268 (32%), Positives = 131/268 (48%), Gaps = 11/268 (4%)
Query: 1 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQ 59
+S D A +S L +AAY G + + L+ + V GRTPL LAA KGH+ V
Sbjct: 542 LSDSDNRATISP-LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVD 600
Query: 60 ILLKAGCDLDVQDDG-DQTALHRATVVGNTEIIAALIHEG---CALDRQDKDGNTALHEA 115
+L+ G + V+D +T +H A G++E + LI A+D QD +G T L +
Sbjct: 601 VLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
Query: 116 SWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGD 175
+G + L+ GANV AK+K G TALH H + LL G++ L+++ G
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
Query: 176 TCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGD----TALHVAAALNHKKVAKILLEAGA 231
T +H++A H+ ++ LL + S+ D TALH A H+ ++LLE
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780
Query: 232 DTTIVNNAGQTPLETARYHNNPEVALLL 259
NA +PL A ++N A +L
Sbjct: 781 FQKTEGNA-FSPLHCAVINDNEGAAEML 807
Score = 102 bits (253), Expect = 2e-21
Identities = 79/256 (30%), Positives = 127/256 (49%), Gaps = 13/256 (5%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L+++ G T+ V L+NKGA V A K GRT LH A GH V LL+ G ++D
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQ----DKDGNTALHEASWHGFSQSAKLLV 128
+T +H + G+ ++ AL+ ++D D G TALH A ++G +LL+
Sbjct: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
Query: 129 KAGANVLAKNKAGN--TALHLACQNSHSQSTRVLL--LAGSRADLKNNAGDTCLHVAARY 184
+ V K + GN + LH A N + + +L+ L S + ++ G T LH AA
Sbjct: 777 EQ--EVFQKTE-GNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFT 833
Query: 185 NHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL-EAGADTTIVNNAGQTP 243
+H+ ++LLL+ V+ + G T L +AA ++L+ A A+ T+ +N+ T
Sbjct: 834 DHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTA 893
Query: 244 LETARYHNNPEVALLL 259
L A + ALL+
Sbjct: 894 LHLACSKGHETSALLI 909
Score = 89.7 bits (221), Expect = 8e-18
Identities = 67/238 (28%), Positives = 115/238 (48%), Gaps = 3/238 (1%)
Query: 29 LINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGN 87
L+ GA V + +K G+TPLH+ A G Q ++++G +D +D T LH A G+
Sbjct: 292 LVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351
Query: 88 TEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHL 147
+I LI G ++ G LH A+ GFS + L+ +G ++ + G T LH
Sbjct: 352 ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHA 411
Query: 148 ACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAG 207
A + + +LL G+ + K+ G + LH AA + + L+ + SV++ ++ G
Sbjct: 412 AAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERG 471
Query: 208 DTALHVAAALN-HKKVAKILLEAGADTTIVNNAGQTPLE-TARYHNNPEVALLLTKAP 263
T LH AA + K + LL A+ I + G + +A Y + + L+ ++ P
Sbjct: 472 CTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETP 529
Score = 85.9 bits (211), Expect = 1e-16
Identities = 56/185 (30%), Positives = 96/185 (51%)
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
DQ +L +A G+ + + ALI + ++ QD + T LH A++ G ++ +LL+ +GA V
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
AK+ T LH A + ++ +VLL + + ++ T LH+AA + L+
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127
Query: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
+V+ ++AG TALH AA H ++ K+LL GA+ + + + A Y + E
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE 187
Query: 255 VALLL 259
V LL
Sbjct: 188 VVKLL 192
Score = 63.9 bits (154), Expect = 5e-10
Identities = 47/150 (31%), Positives = 69/150 (46%), Gaps = 4/150 (2%)
Query: 20 KGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTAL 79
+G E ++ + A GRTPLH AA H+ +Q+LL ++ D +T L
Sbjct: 801 EGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPL 860
Query: 80 HRATVVGNTEIIAALIHEGCA-LDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN---VL 135
A G T + L+ A L QD NTALH A G SA L+++ + +
Sbjct: 861 MMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLIN 920
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGS 165
A N A T LH+A +N + + LL G+
Sbjct: 921 ATNAALQTPLHVAARNGLTMVVQELLGKGA 950
Score = 55.8 bits (133), Expect = 1e-07
Identities = 49/156 (31%), Positives = 76/156 (48%), Gaps = 7/156 (4%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLK-AGCDLDVQ 71
L AA+ E + L++ A+V +V G+TPL +AA G V++L+ A +L +Q
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQ 886
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCA----LDRQDKDGNTALHEASWHGFSQSAKLL 127
D+ TALH A G+ E A LI E ++ + T LH A+ +G + + L
Sbjct: 887 DNSKNTALHLACSKGH-ETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQEL 945
Query: 128 VKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLA 163
+ GA+VLA ++ G T N L+LA
Sbjct: 946 LGKGASVLAVDENGYTPALACAPNKDVADCLALILA 981
Score = 31.2 bits (69), Expect = 3.5
Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 8 AALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTP-LHLAANKGHLPVVQILL 62
AAL L VAA G T V +L+ KGA V AV ++G TP L A NK + ++L
Sbjct: 924 AALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 118 bits (296), Expect = 2e-26
Identities = 78/219 (35%), Positives = 115/219 (52%), Gaps = 2/219 (0%)
Query: 17 AAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
A + G E V L+NKGA + V K R PLH AA GHL V+++L+ G DL +D
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
LH A G E++ L+ G +D + GNTALH A + G A LV AGANV
Sbjct: 207 YGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLL-AGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
N G T LH+A +++ LL+ G+ + ++ G + LH+AA + + ++L+
Sbjct: 267 QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
Query: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADT 233
+ ++ G+T LHVAA H+ + L+ GADT
Sbjct: 327 QNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADT 365
Score = 113 bits (282), Expect = 7e-25
Identities = 75/250 (30%), Positives = 128/250 (51%), Gaps = 1/250 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L+ A + E V L+++ + V + RTPLH AA G +P++Q+LL +G +++ +D
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LHRA N +++ L+ ++ +DK T LH A+ + ++ A+ L +
Sbjct: 72 TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLS 131
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
++ +++G +ALH A + H ++ +LL G+ ++ + LH AA HL +++L
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
L+ + K++ G LH AAA +V K LL GA+ N G T L A Y
Sbjct: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
Query: 253 PEVALLLTKA 262
VA+ L A
Sbjct: 252 DAVAIELVNA 261
Score = 100 bits (250), Expect = 4e-21
Identities = 80/255 (31%), Positives = 115/255 (45%), Gaps = 22/255 (8%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAA--NKGHLPVVQILLKAGCDLDV 70
L +A Y GQ ++L+N GA V G TPLH+AA G L +++L+ G D++
Sbjct: 243 LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNY 301
Query: 71 QDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKA 130
Q ++ LH A + G LI G +D DK GNT LH A+ +G L+
Sbjct: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTN 361
Query: 131 GANVLAKNKAGNTALHLACQNSHSQSTRVL------------------LLAGSRADLKNN 172
GA+ + LHLA S R L L AG + +N
Sbjct: 362 GADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDN 421
Query: 173 AGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
G TCLH AA ++ + LLL++ + +++ G T LH AAA + A L+ AGA
Sbjct: 422 LGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAG 481
Query: 233 TTIVNNAGQTPLETA 247
+ G +PL A
Sbjct: 482 VNEADCKGCSPLHYA 496
Score = 95.9 bits (237), Expect = 1e-19
Identities = 77/229 (33%), Positives = 113/229 (49%), Gaps = 9/229 (3%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAAL-IHEGCALD 102
+PLHLAA GH ++ L + +LDV+D +TAL AT G+TE + L H AL
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646
Query: 103 RQDKDGNTALHEASWHGFSQSAKLLVKAG--ANVL-AKNKAGNTALHLACQNSHSQSTRV 159
++ K T LH A+ G + S LL+ +G A++ + G T L LA N H +
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706
Query: 160 LLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNH 219
LL GS AD + G T LH A + LL V ++ G T +H+A+A H
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH 766
Query: 220 KKVAKILLEAGADT----TIVNNAGQTPLETARYHNNPE-VALLLTKAP 263
V + LL+A T V+ +G +P+ A Y + + + LLL +P
Sbjct: 767 TAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSP 815
Score = 95.9 bits (237), Expect = 1e-19
Identities = 79/263 (30%), Positives = 125/263 (47%), Gaps = 17/263 (6%)
Query: 1 MSQQDAVAALSER------LLVAAYKGQTENVVQLINKGARVAVTK----HGRTPLHLAA 50
++ A A + ER L AA G T+++ LI+ G R +T +G+TPL LA
Sbjct: 637 LTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAI 696
Query: 51 NKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNT 110
GH+ V +LL+ G D D +TALHR V G + +AAL+ + +D G T
Sbjct: 697 MNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRT 756
Query: 111 ALHEASWHGFSQSAKLLVKAGANV----LAKNKAGNTALHLACQNSHSQSTRVLLLAGSR 166
+H AS G + + L++A + + +G + +H A H +LL
Sbjct: 757 PIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPF 816
Query: 167 ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCS--VHEKNQAGDTALHVAAALNHKKVAK 224
+ L+ N T LH A N S +LL A + V+ ++ G T LH AA ++ +
Sbjct: 817 SYLEGNP-FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875
Query: 225 ILLEAGADTTIVNNAGQTPLETA 247
+LL+ A+ ++ G+T L TA
Sbjct: 876 MLLQHQAEVNATDHTGRTALMTA 898
Score = 83.6 bits (205), Expect = 6e-16
Identities = 64/217 (29%), Positives = 100/217 (46%)
Query: 45 PLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQ 104
PL A + V+ LL +++V D +T LH A VG+ I+ L+ G ++ +
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 105 DKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAG 164
D T LH A+ + LL+ A+V A++K T LH+A N ++ L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130
Query: 165 SRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224
S ++ + +G + LH A HL + LLL S++ ++ LH AA L H +V K
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
Query: 225 ILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 261
+L+ GAD + G L TA EV L +
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
Score = 80.9 bits (198), Expect = 4e-15
Identities = 69/241 (28%), Positives = 111/241 (46%), Gaps = 7/241 (2%)
Query: 29 LINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAG--CDLDVQDDGDQTALHRATVV 85
L++ GA ++ + G T +H AA G+ +++LL+ C DV+ + LH A
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
Query: 86 GNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGN-TA 144
G+ E + L LD +D G TAL A+ G ++ ++L GA+ L K + T
Sbjct: 596 GHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTP 655
Query: 145 LHLACQNSHSQSTRVLLLAGSRADL---KNNAGDTCLHVAARYNHLSIIRLLLTAFCSVH 201
LH A + H+ S +L+ +G RAD+ + G T L +A H+ + LLL +
Sbjct: 656 LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTAD 715
Query: 202 EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTK 261
+ G TALH A + LL+ A + G+TP+ A + V L +
Sbjct: 716 AADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775
Query: 262 A 262
A
Sbjct: 776 A 776
Score = 80.1 bits (196), Expect = 7e-15
Identities = 84/296 (28%), Positives = 123/296 (41%), Gaps = 49/296 (16%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAA------------NKGHLPVV-- 58
L VAA G + L+ GA A H PLHLA + G L +
Sbjct: 343 LHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVS 402
Query: 59 ----QILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHE 114
+ +L AG D++ D+ +T LH A GN E + L+ G L R+DK G T LH
Sbjct: 403 SLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHY 462
Query: 115 ASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNS-------HSQST---------- 157
A+ +G Q A LV AGA V + G + LH A + H+ S+
Sbjct: 463 AAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLK 522
Query: 158 -----------RVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL--TAFCSVHEKN 204
LL G+ L++ G T +H AA Y + + LLL + C ++
Sbjct: 523 ESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVES 582
Query: 205 QAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLT 260
+ LH+AA H + K L E + + ++ G+T L A + E +LT
Sbjct: 583 TIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLT 638
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/245 (26%), Positives = 101/245 (41%), Gaps = 44/245 (17%)
Query: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG----DQTALHRATVVGNTEIIAALIHE 97
GRTP+HLA+ GH V++ LL+A D D G + +H A+ G+ + + L+
Sbjct: 754 GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
Query: 98 G--------------CAL--------------------DRQDKDGNTALHEASWHGFSQS 123
CA+ + +D G T LH A++
Sbjct: 814 SPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSG 873
Query: 124 AKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLK--NNAGDTCLHVA 181
++L++ A V A + G TAL A +N + + LL G +ADL + +T LH+A
Sbjct: 874 LRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG-KADLTVLDENKNTALHLA 932
Query: 182 ARYNHLSIIRLLLTAFCS---VHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNN 238
H ++L ++ N A LH+AA V + LL GA V+
Sbjct: 933 CSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDE 992
Query: 239 AGQTP 243
G TP
Sbjct: 993 EGHTP 997
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/185 (27%), Positives = 88/185 (47%)
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
DQ L +A + E + +L+ + ++ D++ T LH A++ G +LL+ +GANV
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
AK+ T LH A + + + +LL + + ++ T LHVAA L
Sbjct: 68 NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127
Query: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE 254
S++ +++G +ALH A H + +LL GA + + + PL A + + E
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLE 187
Query: 255 VALLL 259
V LL
Sbjct: 188 VLKLL 192
Score = 56.2 bits (134), Expect = 1e-07
Identities = 44/150 (29%), Positives = 75/150 (50%), Gaps = 6/150 (4%)
Query: 33 GARVAVTKH--GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEI 90
GA++ ++ GRTPLH AA ++ +++LL+ +++ D +TAL A G T
Sbjct: 847 GAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAA 906
Query: 91 IAALIHEGCA-LDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN---VLAKNKAGNTALH 146
+ L++ G A L D++ NTALH A G + A +++ + + A N A LH
Sbjct: 907 VEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLH 966
Query: 147 LACQNSHSQSTRVLLLAGSRADLKNNAGDT 176
+A +N + + LL G+ + G T
Sbjct: 967 IAARNGLASVVQALLSHGATVLAVDEEGHT 996
Score = 54.7 bits (130), Expect = 3e-07
Identities = 53/150 (35%), Positives = 68/150 (45%), Gaps = 24/150 (16%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKH-GRTPLHLAANKGHLPVVQILLKAG-CDLDVQ 71
L AA+ + L+ A V T H GRT L AA G V+ LL G DL V
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCAL----DRQD----KDGNTAL----HEASWHG 119
D+ TALH A G HE CAL + QD N+AL H A+ +G
Sbjct: 922 DENKNTALHLACSKG---------HEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972
Query: 120 FSQSAKLLVKAGANVLAKNKAGNTALHLAC 149
+ + L+ GA VLA ++ G+T LAC
Sbjct: 973 LASVVQALLSHGATVLAVDEEGHTPA-LAC 1001
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 118 bits (295), Expect = 2e-26
Identities = 76/224 (33%), Positives = 120/224 (53%), Gaps = 2/224 (0%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103
TPL AAN GH+ +V++LL D++ Q TAL A G +++ L+ G +++
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKAGANVLA-KNKAGNTALHLACQNSHSQSTRVLLL 162
+++G+T L EA G + A+LL++ GA + N+ +AL LAC H + R LL
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 163 AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV 222
AG+ + K + T L A H+ + RLLL + V+ + ++ L +AA H ++
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 223 AKILLEAGADTTIVNNAGQTPL-ETARYHNNPEVALLLTKAPQV 265
A +L+E GA VN+ G TPL E AR + VALLL + +
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
Score = 111 bits (278), Expect = 2e-24
Identities = 88/256 (34%), Positives = 125/256 (48%), Gaps = 6/256 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L +AA G E LI +GA + V G TPL AA +GH +V +LL G +++ Q
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ +TAL A G E+ LI G ++ +T L EA+ G + K L+ AG
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAG 587
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
ANV A G+TAL AC+N H+ VLL AG+ + ++ G T L AAR H+ ++
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647
Query: 192 LLLTAFCSVHEKNQAGD-TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
L++ +V+ D T L +A A H V ++LL GAD T G T L A
Sbjct: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707
Query: 251 NNPEVALLLTKAPQVL 266
+ V L P L
Sbjct: 708 GHTSVVCYLLDYPNNL 723
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/225 (32%), Positives = 117/225 (52%), Gaps = 7/225 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A G E V L+ +GA + K G TPL LAA GH+ VV+ILL G D++ Q
Sbjct: 1087 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 1146
Query: 73 DGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ + T L A G E++ L+ G + ++ T L A+ G+ K+L+ AG
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206
Query: 132 ANVLAK--NKAGNTALHLACQNSHSQSTRVLLLAGS--RADLKNNAGDTCLHVAARYNHL 187
A + ++ +K G + L LA N H+ + ++LL GS A ++ N +T L +A
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR-NTALTLACFQGRT 1265
Query: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
++ LLL +V + + G T L AA+ + +V ++LL+ GAD
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1310
Score = 93.6 bits (231), Expect = 6e-19
Identities = 72/252 (28%), Positives = 125/252 (49%), Gaps = 4/252 (1%)
Query: 15 LVAAYKGQTENVVQLI--NKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L+AA G +V+L+ +K A + G T L A G++ VV++LL++G ++ +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKD-GNTALHEASWHGFSQSAKLLVKAG 131
+ T L A G+ E+ L+ G ++ + +AL A + G + + L++AG
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A+ K +TAL AC + H + R+LL +G++ ++ ++ ++ L +AA H+ +
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
Query: 192 LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTI-VNNAGQTPLETARYH 250
LL+ S+ E N G T L AA H+++ +LL GA+ +T L A
Sbjct: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
Query: 251 NNPEVALLLTKA 262
EVA L KA
Sbjct: 545 GFLEVADFLIKA 556
Score = 93.6 bits (231), Expect = 6e-19
Identities = 102/413 (24%), Positives = 172/413 (41%), Gaps = 65/413 (15%)
Query: 14 LLVAAYKGQTENVVQLINKGARV---AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDV 70
L +AA G + L+N GA + +K G +PL LAA GH V++LL G D++
Sbjct: 1187 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 1246
Query: 71 QDDGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129
Q + ++ TAL A G TE+++ L+ ++ + K G T L EA+ G+++ ++L+
Sbjct: 1247 QIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1306
Query: 130 AGANVLA-----------------------------------KNKAGNTALHLACQNSHS 154
GA+V A +NK GNT L LA H
Sbjct: 1307 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHL 1366
Query: 155 QSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQ--AGDTALH 212
++L+ AG+ D +N T L A R H+ ++R L V E NQ + +
Sbjct: 1367 DVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL------VKEVNQFPSDSECMR 1420
Query: 213 VAAALNHKKVAK---ILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
A + K++ K + +E +IV + + A + N + L ++ S
Sbjct: 1421 YIATITDKEMLKKCHLCME-----SIVQAKDR---QAAEANKNASILLEELDLEKLREES 1472
Query: 270 RGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASP 329
R +L KRE+ KE+RR + ++E + + A + + E A+++E L
Sbjct: 1473 RRLALAAKREKRKEKRRKK---KEEQRRKLEEIEAKNKENFELQAAQEKEK----LKVED 1525
Query: 330 EPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSP 382
EP + + S G + N K++NR +P
Sbjct: 1526 EPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITP 1578
Score = 88.6 bits (218), Expect = 2e-17
Identities = 70/245 (28%), Positives = 122/245 (49%), Gaps = 9/245 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L A G + V L+ GA + ++G TPL A + GH+ V ++LL+ G ++
Sbjct: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ ++AL A G+ E++ L+ G + + + +TAL EA G + A+LL+ +G
Sbjct: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A V + + L LA H + +L+ G+ + N+ G T L AAR H ++
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 192 LLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGAD------TTIVNNAGQTPL 244
LLL +++ + + +TAL +A +VA L++AGAD T ++ A + L
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHL 577
Query: 245 ETARY 249
E +Y
Sbjct: 578 ELVKY 582
Score = 82.0 bits (201), Expect = 2e-15
Identities = 61/221 (27%), Positives = 110/221 (49%), Gaps = 10/221 (4%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQ-TALHRATVVGNTEIIAALIHEGCALD 102
TP + + LP+ + D+D Q + + TAL A G+ E++ L+ G +++
Sbjct: 1056 TPSPIISPSAMLPIYPAI-----DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIE 1110
Query: 103 RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKN-KAGNTALHLACQNSHSQSTRVLL 161
+DK G T L A+ G ++L+ GA++ A++ + +T L LAC + +LL
Sbjct: 1111 HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 1170
Query: 162 LAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEK--NQAGDTALHVAAALNH 219
G+ + +N + T L +AA +++II++LL A ++ + ++ G + L +AA H
Sbjct: 1171 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1230
Query: 220 KKVAKILLEAGADTTI-VNNAGQTPLETARYHNNPEVALLL 259
K+LL+ G+D + T L A + EV LL
Sbjct: 1231 TAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
Score = 77.0 bits (188), Expect = 6e-14
Identities = 68/220 (30%), Positives = 104/220 (47%), Gaps = 3/220 (1%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL-DRQDKD 107
A ++G + V+ LL G ++ + ++ L A G E+ L+ + DR K
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167
T L A+ G + KLL+ A+V A++ GNTAL AC + +VLL +G+
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 168 DLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKIL 226
+ N G T L A H+ + RLLL ++ N+ ++AL +A H ++ + L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 227 LEAGADTTIVNNAGQTPLETARYHNNPEVA-LLLTKAPQV 265
LEAGAD + T L A + EVA LLL QV
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
Score = 72.8 bits (177), Expect = 1e-12
Identities = 51/190 (26%), Positives = 96/190 (50%), Gaps = 2/190 (1%)
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
D +L A G+ + L+ EG +++ ++G + L A G+ + A++L+ ANV
Sbjct: 234 DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 293
Query: 135 LAKNKAGN-TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL 193
+ G+ T L A H + ++LL + + +++ G+T L A ++ ++++L
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 194 LTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD-TTIVNNAGQTPLETARYHNN 252
L + S+ + N+ G T L A + H +VA++LLE GA T N ++ L A Y +
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
Query: 253 PEVALLLTKA 262
E+ L +A
Sbjct: 414 LEMVRFLLEA 423
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/156 (26%), Positives = 73/156 (46%), Gaps = 2/156 (1%)
Query: 121 SQSAKLLVKAGANVLAKNKAGN-TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLH 179
S SA L + ++ A+ ++ + TAL LAC H + + LL G+ + ++ G T L
Sbjct: 1062 SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 1121
Query: 180 VAARYNHLSIIRLLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNN 238
+AA H+ ++ +LL + + + DT L +A + ++V ++LL GA+ N
Sbjct: 1122 LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181
Query: 239 AGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSL 274
+ TPL A + +L A + G L
Sbjct: 1182 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 1217
Score = 52.4 bits (124), Expect = 1e-06
Identities = 47/167 (28%), Positives = 68/167 (40%), Gaps = 35/167 (20%)
Query: 5 DAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLK 63
D S L+ AA +G E V L+ GA V A T G T L A GH V +LL+
Sbjct: 559 DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
Query: 64 AGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQD------------------ 105
AG DL+ + +G +T L +A G+ + LI +G ++R
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678
Query: 106 ----------------KDGNTALHEASWHGFSQSAKLLVKAGANVLA 136
KDG+T L EA+ G + L+ N+L+
Sbjct: 679 VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLS 725
Score = 51.2 bits (121), Expect = 3e-06
Identities = 47/173 (27%), Positives = 70/173 (40%), Gaps = 35/173 (20%)
Query: 122 QSAKLLVKAGANVLAK-NKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT--CL 178
++A L + A A ++ N +L AC + R LL+ G + G++ CL
Sbjct: 214 EAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCL 273
Query: 179 HVAARY--------------------------------NHLSIIRLLLTAFCSVHEKNQA 206
+A Y H+ I++LLL V+ ++
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 207 GDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
G+TAL A A + V K+LLE+GA N G TPL A + EVA LL
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 118 bits (295), Expect = 2e-26
Identities = 76/224 (33%), Positives = 120/224 (53%), Gaps = 2/224 (0%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103
TPL AAN GH+ +V++LL D++ Q TAL A G +++ L+ G +++
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKAGANVLA-KNKAGNTALHLACQNSHSQSTRVLLL 162
+++G+T L EA G + A+LL++ GA + N+ +AL LAC H + R LL
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 163 AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV 222
AG+ + K + T L A H+ + RLLL + V+ + ++ L +AA H ++
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 223 AKILLEAGADTTIVNNAGQTPL-ETARYHNNPEVALLLTKAPQV 265
A +L+E GA VN+ G TPL E AR + VALLL + +
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
Score = 111 bits (278), Expect = 2e-24
Identities = 88/256 (34%), Positives = 125/256 (48%), Gaps = 6/256 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L +AA G E LI +GA + V G TPL AA +GH +V +LL G +++ Q
Sbjct: 471 LTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT 530
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ +TAL A G E+ LI G ++ +T L EA+ G + K L+ AG
Sbjct: 531 EETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAG 587
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
ANV A G+TAL AC+N H+ VLL AG+ + ++ G T L AAR H+ ++
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647
Query: 192 LLLTAFCSVHEKNQAGD-TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
L++ +V+ D T L +A A H V ++LL GAD T G T L A
Sbjct: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707
Query: 251 NNPEVALLLTKAPQVL 266
+ V L P L
Sbjct: 708 GHTSVVCYLLDYPNNL 723
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/225 (32%), Positives = 117/225 (52%), Gaps = 7/225 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A G E V L+ +GA + K G TPL LAA GH+ VV+ILL G D++ Q
Sbjct: 836 LTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS 895
Query: 73 DGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ + T L A G E++ L+ G + ++ T L A+ G+ K+L+ AG
Sbjct: 896 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955
Query: 132 ANVLAK--NKAGNTALHLACQNSHSQSTRVLLLAGS--RADLKNNAGDTCLHVAARYNHL 187
A + ++ +K G + L LA N H+ + ++LL GS A ++ N +T L +A
Sbjct: 956 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR-NTALTLACFQGRT 1014
Query: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
++ LLL +V + + G T L AA+ + +V ++LL+ GAD
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1059
Score = 93.6 bits (231), Expect = 6e-19
Identities = 72/252 (28%), Positives = 125/252 (49%), Gaps = 4/252 (1%)
Query: 15 LVAAYKGQTENVVQLI--NKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L+AA G +V+L+ +K A + G T L A G++ VV++LL++G ++ +
Sbjct: 305 LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHN 364
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKD-GNTALHEASWHGFSQSAKLLVKAG 131
+ T L A G+ E+ L+ G ++ + +AL A + G + + L++AG
Sbjct: 365 ENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAG 424
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A+ K +TAL AC + H + R+LL +G++ ++ ++ ++ L +AA H+ +
Sbjct: 425 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 484
Query: 192 LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTI-VNNAGQTPLETARYH 250
LL+ S+ E N G T L AA H+++ +LL GA+ +T L A
Sbjct: 485 LLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCG 544
Query: 251 NNPEVALLLTKA 262
EVA L KA
Sbjct: 545 GFLEVADFLIKA 556
Score = 93.6 bits (231), Expect = 6e-19
Identities = 102/413 (24%), Positives = 172/413 (41%), Gaps = 65/413 (15%)
Query: 14 LLVAAYKGQTENVVQLINKGARV---AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDV 70
L +AA G + L+N GA + +K G +PL LAA GH V++LL G D++
Sbjct: 936 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINA 995
Query: 71 QDDGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129
Q + ++ TAL A G TE+++ L+ ++ + K G T L EA+ G+++ ++L+
Sbjct: 996 QIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1055
Query: 130 AGANVLA-----------------------------------KNKAGNTALHLACQNSHS 154
GA+V A +NK GNT L LA H
Sbjct: 1056 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHL 1115
Query: 155 QSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQ--AGDTALH 212
++L+ AG+ D +N T L A R H+ ++R L V E NQ + +
Sbjct: 1116 DVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYL------VKEVNQFPSDSECMR 1169
Query: 213 VAAALNHKKVAK---ILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFS 269
A + K++ K + +E +IV + + A + N + L ++ S
Sbjct: 1170 YIATITDKEMLKKCHLCME-----SIVQAKDR---QAAEANKNASILLEELDLEKLREES 1221
Query: 270 RGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASP 329
R +L KRE+ KE+RR + ++E + + A + + E A+++E L
Sbjct: 1222 RRLALAAKREKRKEKRRKK---KEEQRRKLEEIEAKNKENFELQAAQEKEK----LKVED 1274
Query: 330 EPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSP 382
EP + + S G + N K++NR +P
Sbjct: 1275 EPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITP 1327
Score = 88.6 bits (218), Expect = 2e-17
Identities = 70/245 (28%), Positives = 122/245 (49%), Gaps = 9/245 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L A G + V L+ GA + ++G TPL A + GH+ V ++LL+ G ++
Sbjct: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ ++AL A G+ E++ L+ G + + + +TAL EA G + A+LL+ +G
Sbjct: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A V + + L LA H + +L+ G+ + N+ G T L AAR H ++
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 192 LLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGAD------TTIVNNAGQTPL 244
LLL +++ + + +TAL +A +VA L++AGAD T ++ A + L
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHL 577
Query: 245 ETARY 249
E +Y
Sbjct: 578 ELVKY 582
Score = 82.0 bits (201), Expect = 2e-15
Identities = 61/221 (27%), Positives = 110/221 (49%), Gaps = 10/221 (4%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQ-TALHRATVVGNTEIIAALIHEGCALD 102
TP + + LP+ + D+D Q + + TAL A G+ E++ L+ G +++
Sbjct: 805 TPSPIISPSAMLPIYPAI-----DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIE 859
Query: 103 RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKN-KAGNTALHLACQNSHSQSTRVLL 161
+DK G T L A+ G ++L+ GA++ A++ + +T L LAC + +LL
Sbjct: 860 HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
Query: 162 LAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEK--NQAGDTALHVAAALNH 219
G+ + +N + T L +AA +++II++LL A ++ + ++ G + L +AA H
Sbjct: 920 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 979
Query: 220 KKVAKILLEAGADTTI-VNNAGQTPLETARYHNNPEVALLL 259
K+LL+ G+D + T L A + EV LL
Sbjct: 980 TAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
Score = 77.0 bits (188), Expect = 6e-14
Identities = 68/220 (30%), Positives = 104/220 (47%), Gaps = 3/220 (1%)
Query: 49 AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL-DRQDKD 107
A ++G + V+ LL G ++ + ++ L A G E+ L+ + DR K
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167
T L A+ G + KLL+ A+V A++ GNTAL AC + +VLL +G+
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASI 360
Query: 168 DLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKIL 226
+ N G T L A H+ + RLLL ++ N+ ++AL +A H ++ + L
Sbjct: 361 EDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFL 420
Query: 227 LEAGADTTIVNNAGQTPLETARYHNNPEVA-LLLTKAPQV 265
LEAGAD + T L A + EVA LLL QV
Sbjct: 421 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
Score = 72.8 bits (177), Expect = 1e-12
Identities = 51/190 (26%), Positives = 96/190 (50%), Gaps = 2/190 (1%)
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
D +L A G+ + L+ EG +++ ++G + L A G+ + A++L+ ANV
Sbjct: 234 DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 293
Query: 135 LAKNKAGN-TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL 193
+ G+ T L A H + ++LL + + +++ G+T L A ++ ++++L
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 194 LTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD-TTIVNNAGQTPLETARYHNN 252
L + S+ + N+ G T L A + H +VA++LLE GA T N ++ L A Y +
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
Query: 253 PEVALLLTKA 262
E+ L +A
Sbjct: 414 LEMVRFLLEA 423
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/156 (26%), Positives = 73/156 (46%), Gaps = 2/156 (1%)
Query: 121 SQSAKLLVKAGANVLAKNKAGN-TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLH 179
S SA L + ++ A+ ++ + TAL LAC H + + LL G+ + ++ G T L
Sbjct: 811 SPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLI 870
Query: 180 VAARYNHLSIIRLLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNN 238
+AA H+ ++ +LL + + + DT L +A + ++V ++LL GA+ N
Sbjct: 871 LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
Query: 239 AGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSL 274
+ TPL A + +L A + G L
Sbjct: 931 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKL 966
Score = 52.4 bits (124), Expect = 1e-06
Identities = 47/167 (28%), Positives = 68/167 (40%), Gaps = 35/167 (20%)
Query: 5 DAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLK 63
D S L+ AA +G E V L+ GA V A T G T L A GH V +LL+
Sbjct: 559 DIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618
Query: 64 AGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQD------------------ 105
AG DL+ + +G +T L +A G+ + LI +G ++R
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLA 678
Query: 106 ----------------KDGNTALHEASWHGFSQSAKLLVKAGANVLA 136
KDG+T L EA+ G + L+ N+L+
Sbjct: 679 VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLS 725
Score = 51.2 bits (121), Expect = 3e-06
Identities = 47/173 (27%), Positives = 70/173 (40%), Gaps = 35/173 (20%)
Query: 122 QSAKLLVKAGANVLAK-NKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT--CL 178
++A L + A A ++ N +L AC + R LL+ G + G++ CL
Sbjct: 214 EAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCL 273
Query: 179 HVAARY--------------------------------NHLSIIRLLLTAFCSVHEKNQA 206
+A Y H+ I++LLL V+ ++
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 207 GDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
G+TAL A A + V K+LLE+GA N G TPL A + EVA LL
Sbjct: 334 GNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 117 bits (294), Expect = 3e-26
Identities = 87/255 (34%), Positives = 125/255 (49%), Gaps = 4/255 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L VAAY G V L ++GA + A ++ RTPLHLA +G + +Q LLK+G D D
Sbjct: 498 LHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALD 557
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
LH A G I L+ G +L+ G T LH A++ G + LL ++ A
Sbjct: 558 QSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHA 617
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAA-RYNHLSIIR 191
N+ A T LHLA ++ LL G+ + +G T LH+A R LS+I
Sbjct: 618 NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVIN 677
Query: 192 LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA-RYH 250
LL +VH +N+ G T H+AA + + K+L+EAGA + + TPL+ A R
Sbjct: 678 -LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSR 736
Query: 251 NNPEVALLLTKAPQV 265
++ L K P V
Sbjct: 737 KQGIMSFLEGKEPSV 751
Score = 108 bits (269), Expect = 2e-23
Identities = 75/232 (32%), Positives = 112/232 (48%), Gaps = 1/232 (0%)
Query: 17 AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
AA G L++ GA V A + G TPLHLAA V ++L+ D ++ +
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
Query: 76 QTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVL 135
+T LH A G+ ++ L +G LD Q ++ T LH A G ++ + L+K+GA
Sbjct: 495 KTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
A +++G LH A ++LL G+ +L + G T LH+AA HL II LL
Sbjct: 555 ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAE 614
Query: 196 AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
+ ++ T LH+AA + V LL+ GAD +G TPL A
Sbjct: 615 SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
Score = 105 bits (262), Expect = 1e-22
Identities = 68/219 (31%), Positives = 113/219 (51%)
Query: 29 LINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNT 88
L+ + + + ++ TPLH +G + V++LL D+D Q T L A
Sbjct: 349 LVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQP 408
Query: 89 EIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLA 148
++ A L+ G +R D+DG LH A+ +G +A+LL+ GA V A+ + G T LHLA
Sbjct: 409 DLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLA 468
Query: 149 CQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGD 208
QN+ R+L+ + +L G T LHVAA + H+S+++LL + + + +
Sbjct: 469 AQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR 528
Query: 209 TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETA 247
T LH+A + + LL++GA ++ +G PL TA
Sbjct: 529 TPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTA 567
Score = 102 bits (253), Expect = 2e-21
Identities = 72/245 (29%), Positives = 109/245 (44%)
Query: 42 GRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCAL 101
G+TPLH+AA GH+ +V++L G +LD Q +T LH A G I L+ G
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
Query: 102 DRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLL 161
D D+ G LH A+ G K+L++ GA++ G T LHLA H + +L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613
Query: 162 LAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKK 221
+ + T LH+AAR+ +++ LL + Q+G T LH+A +
Sbjct: 614 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFL 673
Query: 222 VAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERL 281
LLE A+ N G TP A N + +L +A L G S + L
Sbjct: 674 SVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733
Query: 282 KEERR 286
+ ++
Sbjct: 734 RSRKQ 738
Score = 98.6 bits (244), Expect = 2e-20
Identities = 68/224 (30%), Positives = 102/224 (45%)
Query: 39 TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEG 98
T G TPL +AA + +LL G D + D+ LH A G+ L+ G
Sbjct: 392 TASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHG 451
Query: 99 CALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTR 158
+D Q+++G T LH A+ + F A+LLV A+ G T LH+A H +
Sbjct: 452 ACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVK 511
Query: 159 VLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALN 218
+L G+ D + T LH+A + I+ LL + +Q+G LH AAA
Sbjct: 512 LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
Query: 219 HKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 262
+ K+LL GA + + G TPL A Y + E+ LL ++
Sbjct: 572 KYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAES 615
Score = 97.4 bits (241), Expect = 4e-20
Identities = 73/247 (29%), Positives = 109/247 (44%), Gaps = 1/247 (0%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
LL+AA Q + L+ GA V + G PLH AA G ++LL G +D Q+
Sbjct: 399 LLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE 458
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
T LH A + L+ + + +G T LH A++ G KLL GA
Sbjct: 459 REGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGA 518
Query: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRL 192
+ A+ + T LHLA + ++ + LL +G+ D + +G LH AA I ++
Sbjct: 519 ELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKM 578
Query: 193 LLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNN 252
LL S+ G T LH+AA H ++ +L E+ A+ + TPL A H
Sbjct: 579 LLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGE 638
Query: 253 PEVALLL 259
V L
Sbjct: 639 EAVVSAL 645
Score = 67.8 bits (164), Expect = 3e-11
Identities = 62/242 (25%), Positives = 104/242 (42%), Gaps = 13/242 (5%)
Query: 69 DVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLV 128
++ D L RA + + + + E C + + T LH G + +LL+
Sbjct: 327 ELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKV----TPLHFLVAQGSVEQVRLLL 382
Query: 129 KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLS 188
+V + +G T L +A Q+ +LL G+ A+ + G LH AA+
Sbjct: 383 AHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDG 442
Query: 189 IIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
RLLL V + + G T LH+AA N + VA++L+ AD + G+TPL A
Sbjct: 443 TARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAA 502
Query: 249 YHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTP 308
Y + + LLT S+G L ++ L+ +V R +V + + +G P
Sbjct: 503 YFGHVSLVKLLT--------SQGAELDAQQRNLRTPLHL-AVERGKVRAIQHLLKSGAVP 553
Query: 309 SS 310
+
Sbjct: 554 DA 555
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 117 bits (293), Expect = 4e-26
Identities = 77/252 (30%), Positives = 130/252 (51%), Gaps = 6/252 (2%)
Query: 43 RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD 102
RTPLH AA KG + + +LL+AG +++ D +T L A V + E+ ++ G +
Sbjct: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711
Query: 103 RQDKDGNTALHEASWHGFSQSAKLLVKAG-ANVLAKNKAGNTALHLACQNSHSQSTRVLL 161
+++DG+T LH A+ G + LL+ G +V A++ G T + A ++ H + R+LL
Sbjct: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 771
Query: 162 LAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKK 221
G+ L +N + CLH A+ +I +LL A C +H N GDT LH+AA ++
Sbjct: 772 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 831
Query: 222 VAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRG-RSLRKKRER 280
+ L GA+ + N G T + ++ AL L + LR G R++R ++
Sbjct: 832 CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK---LRLGVGNRAIRTEKII 888
Query: 281 LKEERRA-QSVP 291
++ R ++VP
Sbjct: 889 CRDVARGYENVP 900
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/200 (33%), Positives = 99/200 (49%), Gaps = 4/200 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILL-KAGCDLDVQ 71
L AA KG E L+ GA + AV K RTPL A HL V + ++ + GC +
Sbjct: 655 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 714
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEG-CALDRQDKDGNTALHEASWHGFSQSAKLLVKA 130
+DG T LH A +GN E+++ L+ G ++ QD G T + A+ H + ++L+
Sbjct: 715 EDGS-TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 131 GANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSII 190
GA+V + N LH A + VLL A N GDT LH+AAR ++ +
Sbjct: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 833
Query: 191 RLLLTAFCSVHEKNQAGDTA 210
L L+ + +N+ GDTA
Sbjct: 834 LLFLSRGANPELRNKEGDTA 853
Score = 65.9 bits (159), Expect = 1e-10
Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 4/139 (2%)
Query: 17 AAYKGQTENVVQLINKGARVAVTKH---GRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
AA G E V L++ G +V V G TP+ AA H+ V+++LL G D+ + D+
Sbjct: 724 AAKIGNLEMVSLLLSTG-QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN 782
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
+ LH A+ G+ I L++ C L + G+T LH A+ + L + GAN
Sbjct: 783 EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 842
Query: 134 VLAKNKAGNTALHLACQNS 152
+NK G+TA L + S
Sbjct: 843 PELRNKEGDTAWDLTPERS 861
Score = 60.1 bits (144), Expect = 7e-09
Identities = 43/142 (30%), Positives = 66/142 (46%), Gaps = 2/142 (1%)
Query: 126 LLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYN 185
LL N + ++ T LH A Q + VLL AG+ + + T L A N
Sbjct: 636 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNN 695
Query: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG-ADTTIVNNAGQTPL 244
HL + R ++ V+ K + G T LH AA + + ++ +LL G D ++ G TP+
Sbjct: 696 HLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPI 755
Query: 245 ETARYHNNPEV-ALLLTKAPQV 265
A H + EV +LLT+ V
Sbjct: 756 IWAAEHKHIEVIRMLLTRGADV 777
Score = 37.0 bits (84), Expect = 0.064
Identities = 23/68 (33%), Positives = 35/68 (51%)
Query: 189 IIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
I+ LL + Q+ T LH AA ++ +LL+AGA+ V+ +TPL A
Sbjct: 633 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 692
Query: 249 YHNNPEVA 256
+N+ EVA
Sbjct: 693 VNNHLEVA 700
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 117 bits (293), Expect = 4e-26
Identities = 77/252 (30%), Positives = 130/252 (51%), Gaps = 6/252 (2%)
Query: 43 RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD 102
RTPLH AA KG + + +LL+AG +++ D +T L A V + E+ ++ G +
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745
Query: 103 RQDKDGNTALHEASWHGFSQSAKLLVKAG-ANVLAKNKAGNTALHLACQNSHSQSTRVLL 161
+++DG+T LH A+ G + LL+ G +V A++ G T + A ++ H + R+LL
Sbjct: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL 805
Query: 162 LAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKK 221
G+ L +N + CLH A+ +I +LL A C +H N GDT LH+AA ++
Sbjct: 806 TRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHD 865
Query: 222 VAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRG-RSLRKKRER 280
+ L GA+ + N G T + ++ AL L + LR G R++R ++
Sbjct: 866 CVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRK---LRLGVGNRAIRTEKII 922
Query: 281 LKEERRA-QSVP 291
++ R ++VP
Sbjct: 923 CRDVARGYENVP 934
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/200 (33%), Positives = 99/200 (49%), Gaps = 4/200 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILL-KAGCDLDVQ 71
L AA KG E L+ GA + AV K RTPL A HL V + ++ + GC +
Sbjct: 689 LHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 748
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEG-CALDRQDKDGNTALHEASWHGFSQSAKLLVKA 130
+DG T LH A +GN E+++ L+ G ++ QD G T + A+ H + ++L+
Sbjct: 749 EDGS-TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 131 GANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSII 190
GA+V + N LH A + VLL A N GDT LH+AAR ++ +
Sbjct: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCV 867
Query: 191 RLLLTAFCSVHEKNQAGDTA 210
L L+ + +N+ GDTA
Sbjct: 868 LLFLSRGANPELRNKEGDTA 887
Score = 65.9 bits (159), Expect = 1e-10
Identities = 45/139 (32%), Positives = 69/139 (49%), Gaps = 4/139 (2%)
Query: 17 AAYKGQTENVVQLINKGARVAVTKH---GRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
AA G E V L++ G +V V G TP+ AA H+ V+++LL G D+ + D+
Sbjct: 758 AAKIGNLEMVSLLLSTG-QVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN 816
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
+ LH A+ G+ I L++ C L + G+T LH A+ + L + GAN
Sbjct: 817 EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGAN 876
Query: 134 VLAKNKAGNTALHLACQNS 152
+NK G+TA L + S
Sbjct: 877 PELRNKEGDTAWDLTPERS 895
Score = 60.1 bits (144), Expect = 7e-09
Identities = 43/142 (30%), Positives = 66/142 (46%), Gaps = 2/142 (1%)
Query: 126 LLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYN 185
LL N + ++ T LH A Q + VLL AG+ + + T L A N
Sbjct: 670 LLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNN 729
Query: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAG-ADTTIVNNAGQTPL 244
HL + R ++ V+ K + G T LH AA + + ++ +LL G D ++ G TP+
Sbjct: 730 HLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPI 789
Query: 245 ETARYHNNPEV-ALLLTKAPQV 265
A H + EV +LLT+ V
Sbjct: 790 IWAAEHKHIEVIRMLLTRGADV 811
Score = 37.0 bits (84), Expect = 0.064
Identities = 23/68 (33%), Positives = 35/68 (51%)
Query: 189 IIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETAR 248
I+ LL + Q+ T LH AA ++ +LL+AGA+ V+ +TPL A
Sbjct: 667 ILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAV 726
Query: 249 YHNNPEVA 256
+N+ EVA
Sbjct: 727 VNNHLEVA 734
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 115 bits (289), Expect = 1e-25
Identities = 72/215 (33%), Positives = 113/215 (52%), Gaps = 2/215 (0%)
Query: 17 AAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD 75
AA G + L+ K A V V GRTP+H+A G +V+ILL+ G D+ +Q
Sbjct: 511 AAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDA 570
Query: 76 QTALHRATVVGNTEIIAALIHE-GCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANV 134
LH A G+ I+ L + G +++ Q DG T LH A+ G + A++L+ ++V
Sbjct: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
Query: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
+ T LH+A + H+ + R+LL G+ + + G T LH+AAR HL+ ++LL+
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 690
Query: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEA 229
V + TALH+AAA H +V + L+ A
Sbjct: 691 EEKADVLARGPLNQTALHLAAAHGHSEVVEELVSA 725
Score = 109 bits (273), Expect = 8e-24
Identities = 76/220 (34%), Positives = 99/220 (45%), Gaps = 1/220 (0%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103
T LH AA G ++LL+ ++ D +T +H A G I+ L+ G +
Sbjct: 506 TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL 565
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKA-GANVLAKNKAGNTALHLACQNSHSQSTRVLLL 162
Q KD LH A+W G KLL K G +V A+ G T LHLA Q H + R+L+
Sbjct: 566 QGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILID 625
Query: 163 AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV 222
S ++ + T LHVAA H S RLLL G TALH+AA H
Sbjct: 626 LCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLAT 685
Query: 223 AKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKA 262
K+L+E AD QT L A H + EV L A
Sbjct: 686 VKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSA 725
Score = 107 bits (267), Expect = 4e-23
Identities = 71/181 (39%), Positives = 99/181 (54%), Gaps = 5/181 (2%)
Query: 17 AAYKGQTENVVQLINKGARVAV---TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
AA++G +V+L+ K V+V T GRTPLHLAA +GH V +IL+ D++V
Sbjct: 577 AAWQGHLP-IVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSL 635
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGAN 133
QT LH A G+T L+H G + DG TALH A+ +G + KLLV+ A+
Sbjct: 636 LAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKAD 695
Query: 134 VLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL 193
VLA+ TALHLA + HS+ L+ A DL + G + LH+AA+ H + L
Sbjct: 696 VLARGPLNQTALHLAAAHGHSEVVEELVSA-DVIDLFDEQGLSALHLAAQGRHAQTVETL 754
Query: 194 L 194
L
Sbjct: 755 L 755
Score = 103 bits (257), Expect = 6e-22
Identities = 72/249 (28%), Positives = 119/249 (47%), Gaps = 1/249 (0%)
Query: 12 ERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ 71
++L+ A G T +++++ G + LHLA G + LL + ++
Sbjct: 408 KKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLS 467
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ T LH A ++ L+ +++ +D+D TALH A+ +G S +LL++
Sbjct: 468 NRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A+V + G T +H+ACQ+ R+LL G L+ LH AA HL I++
Sbjct: 528 ASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVK 587
Query: 192 LLL-TAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
LL SV+ + G T LH+AA H +VA+IL++ +D + + QTPL A
Sbjct: 588 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAET 647
Query: 251 NNPEVALLL 259
+ A LL
Sbjct: 648 GHTSTARLL 656
Score = 72.4 bits (176), Expect = 1e-12
Identities = 54/170 (31%), Positives = 76/170 (44%), Gaps = 5/170 (2%)
Query: 101 LDRQDKD-----GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQ 155
L QD D G + LH A G + AK L+ AN N+ G+T LH+A +
Sbjct: 426 LQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRG 485
Query: 156 STRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAA 215
+LL + K+ T LH AA+ S RLLL SV+E + G T +HVA
Sbjct: 486 VVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVAC 545
Query: 216 ALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQV 265
+ + +ILL G D ++ PL A + + + LL K P V
Sbjct: 546 QHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 595
Score = 33.5 bits (75), Expect = 0.71
Identities = 19/58 (32%), Positives = 31/58 (53%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ 71
L +AA G +E V +L++ + G + LHLAA H V+ LL+ G +++Q
Sbjct: 707 LHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQ 764
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 113 bits (282), Expect = 7e-25
Identities = 90/257 (35%), Positives = 130/257 (50%), Gaps = 7/257 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L +AA G E LI +GA + V G TPL AA +GH +V +LL G +++ Q
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ +TAL A G +E+ LI G ++ +T L EAS G + K L+ +G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASG 558
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
ANV A G+TAL AC+N H+ VLL AG+ + ++ G T L AAR HL ++
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618
Query: 192 LLLTAFCSVHEKNQAGD-TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL-ETARY 249
L++ +V+ D T + +A A H V ++LL GAD T G T L E A+
Sbjct: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
Query: 250 HNNPEVALLLTKAPQVL 266
+ V+ LL VL
Sbjct: 679 GHTNVVSYLLDYPNNVL 695
Score = 112 bits (280), Expect = 1e-24
Identities = 75/224 (33%), Positives = 121/224 (54%), Gaps = 2/224 (0%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103
TPL A++ G+L +V++LL D++ Q TAL A G +I+ L++EG ++
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKAGANVLA-KNKAGNTALHLACQNSHSQSTRVLLL 162
+++G+T L EA+ G + A++L+ GA + N+ +AL LAC H R LL
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 163 AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV 222
AG+ + K + T L A H+ + RLLL + V+ + ++ L +AA H ++
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 223 AKILLEAGADTTIVNNAGQTPL-ETARYHNNPEVALLLTKAPQV 265
A +L+E GA+ VN+ G TPL E AR + VALLL + +
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Score = 100 bits (248), Expect = 6e-21
Identities = 78/249 (31%), Positives = 123/249 (49%), Gaps = 3/249 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDL-DVQ 71
L A G V +L+++G V T+ G + L LA + G+ + Q+LL ++ D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ GD T L A+ G +I+ L+ ++ Q GNTAL A GF K+L+ G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSII 190
AN+ N+ G+T L A H + RVLL G+ + +N ++ L +A HL ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 191 RLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
R LL A K TAL A H +VA++LL++GA + ++ ++PL A
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 251 NNPEVALLL 259
+ E+A LL
Sbjct: 449 GHVELAALL 457
Score = 93.6 bits (231), Expect = 6e-19
Identities = 73/225 (32%), Positives = 116/225 (51%), Gaps = 7/225 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A G E V LI + A++ K G TPL LAA GH+ VV+ILL G D++ Q
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
Query: 73 DGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ + T L A G E++ L+ G + ++ T L A+ G+ K+L+ AG
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178
Query: 132 ANVLAK--NKAGNTALHLACQNSHSQSTRVLLLAGS--RADLKNNAGDTCLHVAARYNHL 187
A + ++ +K G + L LA N H + ++LL GS A ++ N +T L +A
Sbjct: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-NTALTLACFQGRA 1237
Query: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
++ LLL +V + + G T L AA+ + +V ++LL+ GAD
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1282
Score = 92.0 bits (227), Expect = 2e-18
Identities = 72/249 (28%), Positives = 124/249 (49%), Gaps = 6/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L A G + V L+N+GA + ++G TPL AA+ GH+ V ++LL G ++
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ ++AL A G+ +++ L+ G + + + +TAL EA G + A+LL+ +G
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A V + + L LA H + +L+ G+ + N+ G T L AAR H ++
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 192 LLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
LLL +++ + + +TAL +A +VA L++AGAD + TPL A
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545
Query: 251 NNPEVALLL 259
+ E+ L
Sbjct: 546 GHLELVKYL 554
Score = 92.0 bits (227), Expect = 2e-18
Identities = 93/355 (26%), Positives = 156/355 (43%), Gaps = 57/355 (16%)
Query: 14 LLVAAYKGQTENVVQLINKGARV---AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDV 70
L +AA G + L+N GA + +K G +PL LAA GH+P V++LL G D++
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1218
Query: 71 QDDGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129
Q + ++ TAL A G E+++ L+ ++ + K G T L EA+ G+++ ++L+
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278
Query: 130 AGANVLA-----------------------------------KNKAGNTALHLACQNSHS 154
GA+V A +NK GNT L LA H
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF 1338
Query: 155 QSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQ--AGDTALH 212
++L+ AG+ D +N T L A R H+ +++ L V E NQ + +
Sbjct: 1339 DVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL------VKEVNQFPSDIECMR 1392
Query: 213 VAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGR 272
A + K++ K + TIV Q + A + N + L + SR +
Sbjct: 1393 YIATITDKELLKKCHQ--CVETIVKAKDQ---QAAEANKNASILLKELDLEKSREESRKQ 1447
Query: 273 SLRKKRERLKEERR----AQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREE 323
+L KRE+ KE+R+ Q ++E ++K ++ + P E E+ +E
Sbjct: 1448 ALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENS-ELPEDEDEEENDEDVEQE 1501
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/198 (27%), Positives = 99/198 (50%), Gaps = 5/198 (2%)
Query: 67 DLDVQDDGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAK 125
D+D + + TAL A G+ E+++ LI ++ +DK G T L A+ G +
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 126 LLVKAGANVLAKN-KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
+L+ G ++ A++ + +T L LAC + +LL G+ + +N + T L +AA
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 185 NHLSIIRLLLTAFCSVHEK--NQAGDTALHVAAALNHKKVAKILLEAGADTTI-VNNAGQ 241
+++II++LL A ++ + ++ G + L +AA H K+LL+ G+D +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 242 TPLETARYHNNPEVALLL 259
T L A + EV LL
Sbjct: 1226 TALTLACFQGRAEVVSLL 1243
Score = 67.0 bits (162), Expect = 6e-11
Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGN--------TALHEASWHGFSQSAKL 126
D L R T + + AL AL R + + +L EA G + +
Sbjct: 168 DPEVLRRLT----SSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRK 223
Query: 127 LVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGD-TCLHVAARYN 185
L+ G +V + G + L LAC + + +VLL + + + N GD T L A+
Sbjct: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283
Query: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
+L I++LLL V+ ++ G+TAL A A + K+LL GA+ N G TPL
Sbjct: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343
Query: 246 TARYHNNPEVALLL 259
A + EVA +L
Sbjct: 344 EAASAGHVEVARVL 357
Score = 53.5 bits (127), Expect = 7e-07
Identities = 47/167 (28%), Positives = 68/167 (40%), Gaps = 35/167 (20%)
Query: 5 DAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLK 63
D S L+ A+ +G E V L+ GA V A T G T L A GH V +LL+
Sbjct: 530 DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 64 AGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQD------------------ 105
AG DL+ + +G +T L +A G+ + LI +G ++R
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLA 649
Query: 106 ----------------KDGNTALHEASWHGFSQSAKLLVKAGANVLA 136
KDG+T L EA+ G + L+ NVL+
Sbjct: 650 VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
Score = 50.8 bits (120), Expect = 4e-06
Identities = 35/134 (26%), Positives = 62/134 (46%), Gaps = 1/134 (0%)
Query: 142 NTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVH 201
+TAL LAC H + VL+ ++ + ++ G T L +AA H+ ++ +LL +
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 202 EKNQ-AGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLT 260
+++ DT L +A + ++V +LL GA+ N + TPL A + +L
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 261 KAPQVLRFSRGRSL 274
A + G L
Sbjct: 1176 NAGAEINSRTGSKL 1189
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 113 bits (282), Expect = 7e-25
Identities = 90/257 (35%), Positives = 130/257 (50%), Gaps = 7/257 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L +AA G E LI +GA + V G TPL AA +GH +V +LL G +++ Q
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ +TAL A G +E+ LI G ++ +T L EAS G + K L+ +G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASG 558
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
ANV A G+TAL AC+N H+ VLL AG+ + ++ G T L AAR HL ++
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618
Query: 192 LLLTAFCSVHEKNQAGD-TALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPL-ETARY 249
L++ +V+ D T + +A A H V ++LL GAD T G T L E A+
Sbjct: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
Query: 250 HNNPEVALLLTKAPQVL 266
+ V+ LL VL
Sbjct: 679 GHTNVVSYLLDYPNNVL 695
Score = 112 bits (280), Expect = 1e-24
Identities = 75/224 (33%), Positives = 121/224 (54%), Gaps = 2/224 (0%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103
TPL A++ G+L +V++LL D++ Q TAL A G +I+ L++EG ++
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKAGANVLA-KNKAGNTALHLACQNSHSQSTRVLLL 162
+++G+T L EA+ G + A++L+ GA + N+ +AL LAC H R LL
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 163 AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV 222
AG+ + K + T L A H+ + RLLL + V+ + ++ L +AA H ++
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 223 AKILLEAGADTTIVNNAGQTPL-ETARYHNNPEVALLLTKAPQV 265
A +L+E GA+ VN+ G TPL E AR + VALLL + +
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Score = 100 bits (248), Expect = 6e-21
Identities = 78/249 (31%), Positives = 123/249 (49%), Gaps = 3/249 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDL-DVQ 71
L A G V +L+++G V T+ G + L LA + G+ + Q+LL ++ D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ GD T L A+ G +I+ L+ ++ Q GNTAL A GF K+L+ G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSII 190
AN+ N+ G+T L A H + RVLL G+ + +N ++ L +A HL ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 191 RLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
R LL A K TAL A H +VA++LL++GA + ++ ++PL A
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 251 NNPEVALLL 259
+ E+A LL
Sbjct: 449 GHVELAALL 457
Score = 93.6 bits (231), Expect = 6e-19
Identities = 73/225 (32%), Positives = 116/225 (51%), Gaps = 7/225 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVT-KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A G E V LI + A++ K G TPL LAA GH+ VV+ILL G D++ Q
Sbjct: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
Query: 73 DGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ + T L A G E++ L+ G + ++ T L A+ G+ K+L+ AG
Sbjct: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178
Query: 132 ANVLAK--NKAGNTALHLACQNSHSQSTRVLLLAGS--RADLKNNAGDTCLHVAARYNHL 187
A + ++ +K G + L LA N H + ++LL GS A ++ N +T L +A
Sbjct: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR-NTALTLACFQGRA 1237
Query: 188 SIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
++ LLL +V + + G T L AA+ + +V ++LL+ GAD
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGAD 1282
Score = 92.0 bits (227), Expect = 2e-18
Identities = 72/249 (28%), Positives = 124/249 (49%), Gaps = 6/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L A G + V L+N+GA + ++G TPL AA+ GH+ V ++LL G ++
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ ++AL A G+ +++ L+ G + + + +TAL EA G + A+LL+ +G
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A V + + L LA H + +L+ G+ + N+ G T L AAR H ++
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 192 LLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
LLL +++ + + +TAL +A +VA L++AGAD + TPL A
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545
Query: 251 NNPEVALLL 259
+ E+ L
Sbjct: 546 GHLELVKYL 554
Score = 92.0 bits (227), Expect = 2e-18
Identities = 93/355 (26%), Positives = 156/355 (43%), Gaps = 57/355 (16%)
Query: 14 LLVAAYKGQTENVVQLINKGARV---AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDV 70
L +AA G + L+N GA + +K G +PL LAA GH+P V++LL G D++
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1218
Query: 71 QDDGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVK 129
Q + ++ TAL A G E+++ L+ ++ + K G T L EA+ G+++ ++L+
Sbjct: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278
Query: 130 AGANVLA-----------------------------------KNKAGNTALHLACQNSHS 154
GA+V A +NK GNT L LA H
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHF 1338
Query: 155 QSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQ--AGDTALH 212
++L+ AG+ D +N T L A R H+ +++ L V E NQ + +
Sbjct: 1339 DVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL------VKEVNQFPSDIECMR 1392
Query: 213 VAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGR 272
A + K++ K + TIV Q + A + N + L + SR +
Sbjct: 1393 YIATITDKELLKKCHQ--CVETIVKAKDQ---QAAEANKNASILLKELDLEKSREESRKQ 1447
Query: 273 SLRKKRERLKEERR----AQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREE 323
+L KRE+ KE+R+ Q ++E ++K ++ + P E E+ +E
Sbjct: 1448 ALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENS-ELPEDEDEEENDEDVEQE 1501
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/198 (27%), Positives = 99/198 (50%), Gaps = 5/198 (2%)
Query: 67 DLDVQDDGDQ-TALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAK 125
D+D + + TAL A G+ E+++ LI ++ +DK G T L A+ G +
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 126 LLVKAGANVLAKN-KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARY 184
+L+ G ++ A++ + +T L LAC + +LL G+ + +N + T L +AA
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 185 NHLSIIRLLLTAFCSVHEK--NQAGDTALHVAAALNHKKVAKILLEAGADTTI-VNNAGQ 241
+++II++LL A ++ + ++ G + L +AA H K+LL+ G+D +
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225
Query: 242 TPLETARYHNNPEVALLL 259
T L A + EV LL
Sbjct: 1226 TALTLACFQGRAEVVSLL 1243
Score = 67.0 bits (162), Expect = 6e-11
Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGN--------TALHEASWHGFSQSAKL 126
D L R T + + AL AL R + + +L EA G + +
Sbjct: 168 DPEVLRRLT----SSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRK 223
Query: 127 LVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGD-TCLHVAARYN 185
L+ G +V + G + L LAC + + +VLL + + + N GD T L A+
Sbjct: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283
Query: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
+L I++LLL V+ ++ G+TAL A A + K+LL GA+ N G TPL
Sbjct: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343
Query: 246 TARYHNNPEVALLL 259
A + EVA +L
Sbjct: 344 EAASAGHVEVARVL 357
Score = 53.5 bits (127), Expect = 7e-07
Identities = 47/167 (28%), Positives = 68/167 (40%), Gaps = 35/167 (20%)
Query: 5 DAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLK 63
D S L+ A+ +G E V L+ GA V A T G T L A GH V +LL+
Sbjct: 530 DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 64 AGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQD------------------ 105
AG DL+ + +G +T L +A G+ + LI +G ++R
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLA 649
Query: 106 ----------------KDGNTALHEASWHGFSQSAKLLVKAGANVLA 136
KDG+T L EA+ G + L+ NVL+
Sbjct: 650 VVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
Score = 50.8 bits (120), Expect = 4e-06
Identities = 35/134 (26%), Positives = 62/134 (46%), Gaps = 1/134 (0%)
Query: 142 NTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVH 201
+TAL LAC H + VL+ ++ + ++ G T L +AA H+ ++ +LL +
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 202 EKNQ-AGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLT 260
+++ DT L +A + ++V +LL GA+ N + TPL A + +L
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 261 KAPQVLRFSRGRSL 274
A + G L
Sbjct: 1176 NAGAEINSRTGSKL 1189
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 112 bits (280), Expect = 1e-24
Identities = 86/282 (30%), Positives = 128/282 (45%), Gaps = 42/282 (14%)
Query: 10 LSERLLVAAYKGQTENVVQLINK-GARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDL 68
L+E L+ AA G V L+ + V G T + A+ GH+ ++++LLK D+
Sbjct: 431 LNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDV 490
Query: 69 DVQD-DGD--------------------------------QTALHRATVVGNTEIIAALI 95
+ +D DGD QT LH A G+ +++ L+
Sbjct: 491 EAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLL 550
Query: 96 HEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQ 155
GC QD +G+T LH+A +L++AGA+V N G ALH A +
Sbjct: 551 DFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPS 610
Query: 156 STRVLLLAGSR---ADLKNNAGDTCLHVAARYNHLSIIRLLL---TAFCSVHEKNQAGDT 209
+ RVLL R D K + G T LH+AA NH+ + LL+ A + NQ T
Sbjct: 611 AMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQ--QT 668
Query: 210 ALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHN 251
ALH+A H ++ ++L+ AGA I + G TPL A H+
Sbjct: 669 ALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHH 710
Score = 109 bits (273), Expect = 8e-24
Identities = 86/281 (30%), Positives = 129/281 (45%), Gaps = 47/281 (16%)
Query: 12 ERLLVAAYKGQTENVVQLINKGARV--AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLD 69
+R + A G V++++++G+ A K +TPLH+A NKGHL VV+ LL GC
Sbjct: 498 DRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPS 557
Query: 70 VQDDGDQTALHRATVVGNTEIIAALIHEGC------------------------------ 99
+QD T LH A +I+A L+ G
Sbjct: 558 LQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLS 617
Query: 100 ------ALDRQDKDGNTALHEASWHGFSQSAKLLVKAG-ANVLAKNKAGNTALHLACQNS 152
+D + DG TALH A+ + + A+LLV G AN+ +N TALHLA +
Sbjct: 618 KLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQ 677
Query: 153 HSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLL--------LTAFCSVHEKN 204
H+Q R+L+ AG++ D+++ GDT LH A R++ LS +R L + A +
Sbjct: 678 HTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNT 737
Query: 205 QAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
A + +A L GAD +I N GQ+PL+
Sbjct: 738 LIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLD 778
Score = 94.4 bits (233), Expect = 3e-19
Identities = 75/240 (31%), Positives = 115/240 (47%), Gaps = 5/240 (2%)
Query: 24 ENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD-GDQTALHRA 82
E + QL+ K + L AA G + V+ LLK D+DV TA+ A
Sbjct: 413 ERLSQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRP-DVDVNGQCAGHTAMQAA 471
Query: 83 TVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGN 142
+ G+ +I+ L+ + ++ +DKDG+ A+H A++ ++L + A++ A+NK
Sbjct: 472 SQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQ 531
Query: 143 TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHE 202
T LH+A H Q + LL G L+++ GDT LH A I+ +LL A V
Sbjct: 532 TPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTI 591
Query: 203 KNQAGDTALHVAAALNHKKVAKILLEAGADTTIVN---NAGQTPLETARYHNNPEVALLL 259
N G ALH AA + ++LL IV+ + G T L A +N+ EVA LL
Sbjct: 592 TNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELL 651
Score = 91.7 bits (226), Expect = 2e-18
Identities = 63/190 (33%), Positives = 91/190 (47%), Gaps = 12/190 (6%)
Query: 87 NTEIIAALIHEGCA-----LDRQDKD------GNTALHEASWHGFSQSAKLLVKAGANVL 135
N E++ A + A L R D D G+TA+ AS +G KLL+K +V
Sbjct: 432 NEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLLLKQNVDVE 491
Query: 136 AKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLT 195
A++K G+ A+H A VL + + +N T LH+A HL +++ LL
Sbjct: 492 AEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLD 551
Query: 196 AFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPE- 254
C ++ GDT LH A + + +LLEAGAD TI NN G L A NP
Sbjct: 552 FGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
Query: 255 VALLLTKAPQ 264
+ +LL+K P+
Sbjct: 612 MRVLLSKLPR 621
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 112 bits (280), Expect = 1e-24
Identities = 75/224 (33%), Positives = 121/224 (54%), Gaps = 2/224 (0%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103
TPL A++ G+L +V++LL D++ Q TAL A G +I+ L++EG ++
Sbjct: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKAGANVLA-KNKAGNTALHLACQNSHSQSTRVLLL 162
+++G+T L EA+ G + A++L+ GA + N+ +AL LAC H R LL
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 163 AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV 222
AG+ + K + T L A H+ + RLLL + V+ + ++ L +AA H ++
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 223 AKILLEAGADTTIVNNAGQTPL-ETARYHNNPEVALLLTKAPQV 265
A +L+E GA+ VN+ G TPL E AR + VALLL + +
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
Score = 108 bits (271), Expect = 1e-23
Identities = 76/221 (34%), Positives = 113/221 (51%), Gaps = 5/221 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGA-RVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A YKG + V L+ GA + T T L A GH+ V ++LL +G +++
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 435
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
D ++ L A G+ E+ A LI G L+ + +G T L EA+ G + LL+ GA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 133 NVLAKNK-AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
N+ A+ + TAL LAC S+ L+ AG+ +L T L A++ HL +++
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVK 552
Query: 192 LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
LL + +VH GDTAL A H VA +LL+AGAD
Sbjct: 553 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
Score = 100 bits (248), Expect = 6e-21
Identities = 78/249 (31%), Positives = 123/249 (49%), Gaps = 3/249 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDL-DVQ 71
L A G V +L+++G V T+ G + L LA + G+ + Q+LL ++ D
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ GD T L A+ G +I+ L+ ++ Q GNTAL A GF K+L+ G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSII 190
AN+ N+ G+T L A H + RVLL G+ + +N ++ L +A HL ++
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 191 RLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
R LL A K TAL A H +VA++LL++GA + ++ ++PL A
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 251 NNPEVALLL 259
+ E+A LL
Sbjct: 449 GHVELAALL 457
Score = 92.0 bits (227), Expect = 2e-18
Identities = 72/249 (28%), Positives = 124/249 (49%), Gaps = 6/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L A G + V L+N+GA + ++G TPL AA+ GH+ V ++LL G ++
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ ++AL A G+ +++ L+ G + + + +TAL EA G + A+LL+ +G
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A V + + L LA H + +L+ G+ + N+ G T L AAR H ++
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 192 LLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
LLL +++ + + +TAL +A +VA L++AGAD + TPL A
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545
Query: 251 NNPEVALLL 259
+ E+ L
Sbjct: 546 GHLELVKYL 554
Score = 82.8 bits (203), Expect = 1e-15
Identities = 70/252 (27%), Positives = 114/252 (45%), Gaps = 6/252 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV--TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ 71
L+ AA G E L++ GA + + + L LA KGHL +V+ LL+AG D + +
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
D TAL A + G+ E+ L+ G ++ + L A+ G + A LL++ G
Sbjct: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNN-AGDTCLHVAARYNHLSII 190
AN+ N G T L A + H + +LL G+ + + +T L +A +
Sbjct: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
Query: 191 RLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
L+ A + T L A+ H ++ K LL +GA+ G T L A +
Sbjct: 522 DFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
Query: 251 NNPEVALLLTKA 262
+ +VA +L +A
Sbjct: 579 GHTDVADVLLQA 590
Score = 82.8 bits (203), Expect = 1e-15
Identities = 59/157 (37%), Positives = 83/157 (52%), Gaps = 5/157 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L +AA G E LI +GA + V G TPL AA +GH +V +LL G +++ Q
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ +TAL A G +E+ LI G ++ +T L EAS G + K L+ +G
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASG 558
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
ANV A G+TAL AC+N H+ VLL AG+ D
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 67.0 bits (162), Expect = 6e-11
Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGN--------TALHEASWHGFSQSAKL 126
D L R T + + AL AL R + + +L EA G + +
Sbjct: 168 DPEVLRRLT----SSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRK 223
Query: 127 LVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGD-TCLHVAARYN 185
L+ G +V + G + L LAC + + +VLL + + + N GD T L A+
Sbjct: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283
Query: 186 HLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLE 245
+L I++LLL V+ ++ G+TAL A A + K+LL GA+ N G TPL
Sbjct: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343
Query: 246 TARYHNNPEVALLL 259
A + EVA +L
Sbjct: 344 EAASAGHVEVARVL 357
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/70 (41%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 5 DAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLK 63
D S L+ A+ +G E V L+ GA V A T G T L A GH V +LL+
Sbjct: 530 DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 64 AGCDLDVQDD 73
AG DLD Q+D
Sbjct: 590 AGADLDKQED 599
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/92 (32%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
L +A G +E LI GA + + TPL A+ +GHL +V+ LL +G ++
Sbjct: 509 LTLACCGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA 566
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQD 105
TAL A G+T++ L+ G LD+Q+
Sbjct: 567 TGDTALTYACENGHTDVADVLLQAGADLDKQE 598
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 112 bits (280), Expect = 1e-24
Identities = 75/224 (33%), Positives = 121/224 (54%), Gaps = 2/224 (0%)
Query: 44 TPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDR 103
TPL A++ G+L +V++LL D++ Q TAL A G +I+ L++EG ++
Sbjct: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
Query: 104 QDKDGNTALHEASWHGFSQSAKLLVKAGANVLA-KNKAGNTALHLACQNSHSQSTRVLLL 162
+++G+T L EA+ G + A++L+ GA + N+ +AL LAC H R LL
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
Query: 163 AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV 222
AG+ + K + T L A H+ + RLLL + V+ + ++ L +AA H ++
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
Query: 223 AKILLEAGADTTIVNNAGQTPL-ETARYHNNPEVALLLTKAPQV 265
A +L+E GA+ VN+ G TPL E AR + VALLL + +
Sbjct: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 486
Score = 108 bits (271), Expect = 1e-23
Identities = 76/221 (34%), Positives = 113/221 (51%), Gaps = 5/221 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGA-RVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
L +A YKG + V L+ GA + T T L A GH+ V ++LL +G +++
Sbjct: 365 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 424
Query: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
D ++ L A G+ E+ A LI G L+ + +G T L EA+ G + LL+ GA
Sbjct: 425 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 484
Query: 133 NVLAKNK-AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
N+ A+ + TAL LAC S+ L+ AG+ +L T L A++ HL +++
Sbjct: 485 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVK 541
Query: 192 LLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGAD 232
LL + +VH GDTAL A H VA +LL+AGAD
Sbjct: 542 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
Score = 100 bits (248), Expect = 6e-21
Identities = 78/249 (31%), Positives = 123/249 (49%), Gaps = 3/249 (1%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDL-DVQ 71
L A G V +L+++G V T+ G + L LA + G+ + Q+LL ++ D
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
+ GD T L A+ G +I+ L+ ++ Q GNTAL A GF K+L+ G
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSII 190
AN+ N+ G+T L A H + RVLL G+ + +N ++ L +A HL ++
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
Query: 191 RLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
R LL A K TAL A H +VA++LL++GA + ++ ++PL A
Sbjct: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
Query: 251 NNPEVALLL 259
+ E+A LL
Sbjct: 438 GHVELAALL 446
Score = 92.0 bits (227), Expect = 2e-18
Identities = 72/249 (28%), Positives = 124/249 (49%), Gaps = 6/249 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L A G + V L+N+GA + ++G TPL AA+ GH+ V ++LL G ++
Sbjct: 298 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 357
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ ++AL A G+ +++ L+ G + + + +TAL EA G + A+LL+ +G
Sbjct: 358 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 417
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIR 191
A V + + L LA H + +L+ G+ + N+ G T L AAR H ++
Sbjct: 418 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 477
Query: 192 LLLTAFCSVH-EKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
LLL +++ + + +TAL +A +VA L++AGAD + TPL A
Sbjct: 478 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 534
Query: 251 NNPEVALLL 259
+ E+ L
Sbjct: 535 GHLELVKYL 543
Score = 82.8 bits (203), Expect = 1e-15
Identities = 70/252 (27%), Positives = 114/252 (45%), Gaps = 6/252 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAV--TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ 71
L+ AA G E L++ GA + + + L LA KGHL +V+ LL+AG D + +
Sbjct: 331 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 390
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
D TAL A + G+ E+ L+ G ++ + L A+ G + A LL++ G
Sbjct: 391 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 450
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNN-AGDTCLHVAARYNHLSII 190
AN+ N G T L A + H + +LL G+ + + +T L +A +
Sbjct: 451 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 510
Query: 191 RLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYH 250
L+ A + T L A+ H ++ K LL +GA+ G T L A +
Sbjct: 511 DFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 567
Query: 251 NNPEVALLLTKA 262
+ +VA +L +A
Sbjct: 568 GHTDVADVLLQA 579
Score = 82.8 bits (203), Expect = 1e-15
Identities = 59/157 (37%), Positives = 83/157 (52%), Gaps = 5/157 (3%)
Query: 14 LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQ- 71
L +AA G E LI +GA + V G TPL AA +GH +V +LL G +++ Q
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
Query: 72 DDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAG 131
++ +TAL A G +E+ LI G ++ +T L EAS G + K L+ +G
Sbjct: 491 EETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASG 547
Query: 132 ANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168
ANV A G+TAL AC+N H+ VLL AG+ D
Sbjct: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 68.2 bits (165), Expect = 3e-11
Identities = 63/215 (29%), Positives = 94/215 (43%), Gaps = 20/215 (9%)
Query: 65 GCDLDVQDDGDQT---ALHRATVVGNTEIIAALIHE-GCALD---------RQDKDGNT- 110
G DL D Q AL A + E++ L CALD + + N
Sbjct: 132 GADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAG 191
Query: 111 -----ALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGS 165
+L EA G + + L+ G +V + G + L LAC + + +VLL +
Sbjct: 192 QVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 251
Query: 166 RADLKNNAGD-TCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAK 224
+ + N GD T L A+ +L I++LLL V+ ++ G+TAL A A + K
Sbjct: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
Query: 225 ILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
+LL GA+ N G TPL A + EVA +L
Sbjct: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 346
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/70 (41%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 5 DAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLK 63
D S L+ A+ +G E V L+ GA V A T G T L A GH V +LL+
Sbjct: 519 DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 578
Query: 64 AGCDLDVQDD 73
AG DLD Q+D
Sbjct: 579 AGADLDKQED 588
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/92 (32%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
L +A G +E LI GA + + TPL A+ +GHL +V+ LL +G ++
Sbjct: 498 LTLACCGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA 555
Query: 74 GDQTALHRATVVGNTEIIAALIHEGCALDRQD 105
TAL A G+T++ L+ G LD+Q+
Sbjct: 556 TGDTALTYACENGHTDVADVLLQAGADLDKQE 587
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.125 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,800,081
Number of Sequences: 37866
Number of extensions: 1314122
Number of successful extensions: 11704
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 387
Number of HSP's successfully gapped in prelim test: 268
Number of HSP's that attempted gapping in prelim test: 6305
Number of HSP's gapped (non-prelim): 2936
length of query: 722
length of database: 18,247,518
effective HSP length: 110
effective length of query: 612
effective length of database: 14,082,258
effective search space: 8618341896
effective search space used: 8618341896
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.