Search of human proteins with 54860105

Search of human proteins with 54860105

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54860105 nadrin isoform 2 [Homo sapiens]
         (803 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54860105 nadrin isoform 2 [Homo sapiens]                          1637   0.0  
gi|54860079 nadrin isoform 1 [Homo sapiens]                          1562   0.0  
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]       640   0.0  
gi|85815829 SH3-domain binding protein 1 [Homo sapiens]               503   e-142
gi|23510413 sorting nexin 26 [Homo sapiens]                           125   2e-28
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa...   117   3e-26
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa...   117   6e-26
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...   117   6e-26
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]            114   4e-25
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]   108   3e-23
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]    108   3e-23
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap...   107   4e-23
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap...   107   4e-23
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          106   7e-23
gi|4505507 oligophrenin 1 [Homo sapiens]                              104   3e-22
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]           102   1e-21
gi|21314774 T-cell activation Rho GTPase-activating protein isof...   102   2e-21
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi...   100   4e-21
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi...   100   4e-21
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]          100   5e-21
gi|229094128 active breakpoint cluster region-related  protein i...    99   2e-20
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ...    99   2e-20
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]       99   2e-20
gi|38679957 active breakpoint cluster region-related  protein is...    99   2e-20
gi|38679954 active breakpoint cluster region-related  protein is...    99   2e-20
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap...    99   2e-20
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi...    99   2e-20
gi|33356170 myosin IXB isoform 1 [Homo sapiens]                        98   3e-20
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi...    97   5e-20
gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]              96   1e-19

>gi|54860105 nadrin isoform 2 [Homo sapiens]
          Length = 803

 Score = 1637 bits (4238), Expect = 0.0
 Identities = 803/803 (100%), Positives = 803/803 (100%)

Query: 1   MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
           MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT
Sbjct: 1   MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60

Query: 61  DAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIV 120
           DAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIV
Sbjct: 61  DAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIV 120

Query: 121 DPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEM 180
           DPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEM
Sbjct: 121 DPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEM 180

Query: 181 DEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH 240
           DEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH
Sbjct: 181 DEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH 240

Query: 241 QDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLK 300
           QDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLK
Sbjct: 241 QDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLK 300

Query: 301 AALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL 360
           AALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL
Sbjct: 301 AALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL 360

Query: 361 WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA 420
           WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA
Sbjct: 361 WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA 420

Query: 421 AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERK 480
           AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERK
Sbjct: 421 AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERK 480

Query: 481 RPASMAVMEGDLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQP 540
           RPASMAVMEGDLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQP
Sbjct: 481 RPASMAVMEGDLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQP 540

Query: 541 HNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPP 600
           HNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPP
Sbjct: 541 HNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPP 600

Query: 601 TQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNP 660
           TQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNP
Sbjct: 601 TQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNP 660

Query: 661 MALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPR 720
           MALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPR
Sbjct: 661 MALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPR 720

Query: 721 PVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSD 780
           PVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSD
Sbjct: 721 PVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSD 780

Query: 781 SASKDVPGRILLDIDNDTESTAL 803
           SASKDVPGRILLDIDNDTESTAL
Sbjct: 781 SASKDVPGRILLDIDNDTESTAL 803


>gi|54860079 nadrin isoform 1 [Homo sapiens]
          Length = 881

 Score = 1562 bits (4044), Expect = 0.0
 Identities = 788/881 (89%), Positives = 792/881 (89%), Gaps = 78/881 (8%)

Query: 1   MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
           MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT
Sbjct: 1   MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60

Query: 61  DAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIV 120
           DAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIV
Sbjct: 61  DAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIV 120

Query: 121 DPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEM 180
           DPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEM
Sbjct: 121 DPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEM 180

Query: 181 DEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH 240
           DEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH
Sbjct: 181 DEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH 240

Query: 241 QDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLK 300
           QDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLK
Sbjct: 241 QDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLK 300

Query: 301 AALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL 360
           AALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL
Sbjct: 301 AALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL 360

Query: 361 WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA 420
           WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA
Sbjct: 361 WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA 420

Query: 421 AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERK 480
           AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERK
Sbjct: 421 AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERK 480

Query: 481 RPASMAVMEGDLVKKES---------------------------PPKPKDPVSAAVPA-- 511
           RPASMAVMEGDLVKKES                           PP P    S  VPA  
Sbjct: 481 RPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTVVPAGP 540

Query: 512 ---PGRNNSQIASG---------------------------------------------- 522
              P  + ++ +SG                                              
Sbjct: 541 EPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASG 600

Query: 523 QNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTS 582
           QNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTS
Sbjct: 601 QNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTS 660

Query: 583 QHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPT 642
           QHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPT
Sbjct: 661 QHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPT 720

Query: 643 QATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLA 702
           QATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLA
Sbjct: 721 QATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLA 780

Query: 703 GGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDS 762
           GGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDS
Sbjct: 781 GGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDS 840

Query: 763 NSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL 803
           NSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL
Sbjct: 841 NSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL 881


>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
          Length = 818

 Score =  640 bits (1652), Expect = 0.0
 Identities = 367/765 (47%), Positives = 471/765 (61%), Gaps = 113/765 (14%)

Query: 1   MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT 60
           MKKQFNRM+QLANQTVGRAEKTEVLSEDLLQ+E+RL+ V+ + H +HK+L AC QGQ G 
Sbjct: 1   MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA 60

Query: 61  DAERRHKKLPLTALAQNMQEASTQL-EDSLLGKMLETCGDAENQLALELSQHEVFVEKEI 119
           +A++R KKLPLT LAQ + E S  L +D+LLGKML+ CG+ E++LA EL   E+ VE+++
Sbjct: 61  EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV 120

Query: 120 VDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSG--TNFQGLPSKIDTLK 177
           ++PL+ +AEVEIPNIQKQRK LA+LVLD DS R RW Q  KSSG  ++ Q   +K D L+
Sbjct: 121 IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR 180

Query: 178 EEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEM 237
           EEM+EA N+VE C+DQL+ADMY+F+AKE +Y  +F TL+E QA+YHRK+L +L+  LP++
Sbjct: 181 EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI 240

Query: 238 RAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLK 297
           +A Q+ W EKP+FG PLEEHL  SGREIA PIEACV +LLE GM+EEGLFR+   ASKLK
Sbjct: 241 KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK 300

Query: 298 KLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKL 357
           KLKAALDC    + E+ +DPHA+AGALKSYLRELPEPLMTF LY+EW Q ++VQ+QDKKL
Sbjct: 301 KLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360

Query: 358 QDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLA 417
           Q LW  C+KLP  N  N RYLIKFL+KL++  DVNKMTPSN+AIVLGPNLLW + EG + 
Sbjct: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT 420

Query: 418 EMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTL 477
           EM    S+ +V +IEPIIQHADWFFP E+EFN++  +      + N ++ +    D    
Sbjct: 421 EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA 480

Query: 478 ER------KRPASMA-----------------------VMEGDLVKKE------------ 496
           +R      +RP S+A                       VM+ + V +             
Sbjct: 481 DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAP 540

Query: 497 ---SPPKPKDPVSAAVPA-------------------------PGRNNSQIASGQNQPQA 528
               PP P   ++A +P+                         P R ++  +   +   A
Sbjct: 541 PSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSA 600

Query: 529 AAGSHQLSMG--------------QPHNAAGPS-------PHTLRRAVKKPAPAPPKPGN 567
             GS   S G              QP  +  PS       PHTLR+  KK AP PPK   
Sbjct: 601 QKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPK--- 657

Query: 568 PPPGHPGGQSSSGTSQ-HPPSLSPKPPTRSPSP----PTQHTGQPPGQ--PSAPSQLSAP 620
            P G PG  +     Q  P SLSP PP+ +PSP      Q      GQ  P+A   L++P
Sbjct: 658 VPFGQPGAMADQSAGQPSPVSLSPTPPS-TPSPYGLSYPQGYSLASGQLSPAAAPPLASP 716

Query: 621 RRYSSSLS-------PIQAPNHPPPQPPTQATPLMHTKPNSQGPP 658
             ++S+LS       P Q P  PPPQPPT    L  + P S   P
Sbjct: 717 SVFTSTLSKSRPTPKPRQRPTLPPPQPPT--VNLSASSPQSTEAP 759


>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
          Length = 701

 Score =  503 bits (1294), Expect = e-142
 Identities = 318/774 (41%), Positives = 435/774 (56%), Gaps = 109/774 (14%)

Query: 1   MKKQFNRMKQLANQ-TVGRAEKT-EVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQH 58
           MK+Q +RM+QLA   ++GR  +T E L EDLLQ+E+RL+  +   H+ HKRL AC QGQ 
Sbjct: 2   MKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQS 61

Query: 59  GTDAERRHKKLPLTALAQNMQEASTQLE-DSLLGKMLETCGDAENQLALELSQHEVFVEK 117
           G D ++R KKLPL AL+  M E+  +L+ DS +GK LE     +NQLA  L++ E+ +E+
Sbjct: 62  GADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLER 121

Query: 118 EIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGL-------- 169
           +++ PL  ++E E+P I K +K L +LV DW+++++R +QA K+SG++ QGL        
Sbjct: 122 DVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSS-QGLGGSPGSHS 180

Query: 170 ----PSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRK 225
                +K++TLKEE +E   KVEQC+D+  AD+Y+F+ KE  Y  +F+ LLE QADYHR+
Sbjct: 181 HTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRR 240

Query: 226 ALAVLEKTLPEMRAHQDKWAEKPA---------FGTPLEEHLKRSGREIALPIEACVMLL 276
           +L+ L+  L E+R +  +    P+         +G  L  HL+  GREIALPIEACVM+L
Sbjct: 241 SLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMML 300

Query: 277 LETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLM 336
           L  GMKEEGLFR+ AGAS LK+LK  +      L+EF SDPHAVAGALKSYLRELPEPLM
Sbjct: 301 LSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLM 360

Query: 337 TFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTP 396
           TF+LY++W + AS+++   +LQ L   C +LPP+N  N RYL+KFLA+LA+  +VNKMTP
Sbjct: 361 TFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTP 420

Query: 397 SNIAIVLGPNLLW-ARNEGTLAEMAAA--TSVHVVAVIEPIIQHADWFFPEEVEFNVSEA 453
           SNIAIVLGPNLLW    EG  A++ AA  +S+ VV V+E +IQ AD  FP ++ FNVS  
Sbjct: 421 SNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGL 480

Query: 454 FVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESPPKPKDPVSAAVPAPG 513
           F  +T            D+ S  L  +   S AV         +P     P  A  PAP 
Sbjct: 481 FSAVTL----------QDTVSDRLASEELPSTAV--------PTPATTPAPAPAPAPAPA 522

Query: 514 RNNSQIAS---GQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPP 570
              +  A+    +++      S +++   P  AA      + R  K+PAPA  +P  PPP
Sbjct: 523 PALASAATKERTESEVPPRPASPKVTRSPPETAA--PVEDMARRTKRPAPA--RPTMPPP 578

Query: 571 GHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPI 630
              G +SS                  P+PP      PPG  S  +  + PRR     S +
Sbjct: 579 QVSGSRSS-----------------PPAPPL-----PPGSGSPGTPQALPRRLVG--SSL 614

Query: 631 QAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGK 690
           +AP  PPP PPT              PP P    S      PS   P +P P S  P+  
Sbjct: 615 RAPTVPPPLPPT--------------PPQPARRQSRRSPASPS---PASPGPASPSPVSL 657

Query: 691 QNPSLP--APQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHS 742
            NP+       T  GG PE              VP P   P++PP P+P  + S
Sbjct: 658 SNPAQVDLGAATAEGGAPEAIS----------GVPTP---PAIPPQPRPRSLAS 698



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 55/224 (24%), Positives = 71/224 (31%), Gaps = 56/224 (25%)

Query: 532 SHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPK 591
           S +L+  +  + A P+P T       PAPAP     P P      +   T    P   P 
Sbjct: 491 SDRLASEELPSTAVPTPATT------PAPAPAPAPAPAPALASAATKERTESEVPP-RPA 543

Query: 592 PPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTK 651
            P  + SPP   T  P    +  ++  AP R +     +      PP PP          
Sbjct: 544 SPKVTRSPP--ETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLP-------- 593

Query: 652 PNSQGPPNPMALPSE---HGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPET 708
           P S  P  P ALP       L  P+  PP  PTP                          
Sbjct: 594 PGSGSPGTPQALPRRLVGSSLRAPTVPPPLPPTP-------------------------- 627

Query: 709 AQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTA 752
                     P+P  +   R    P P  PG  S    SL+N A
Sbjct: 628 ----------PQPARRQSRRSPASPSPASPGPASPSPVSLSNPA 661



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 28/117 (23%), Positives = 39/117 (33%), Gaps = 14/117 (11%)

Query: 641 PTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQT 700
           P+ A P   T P     P P   P+         T  + P  P++P + +  P   AP  
Sbjct: 500 PSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAP-- 557

Query: 701 LAGGNPETAQPHAGTLPRPRP----VPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAP 753
                    +  A    RP P    +P P+   S   PP PP    +G        P
Sbjct: 558 --------VEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALP 606



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 23/77 (29%), Positives = 26/77 (33%), Gaps = 21/77 (27%)

Query: 706 PETAQPHAGTLPRPRPVPKPRNRPS-------------VPPPPQPPGVHSAGDSSLTNTA 752
           P TA P   T P P P P P   P+             VPP P  P V        T + 
Sbjct: 500 PSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKV--------TRSP 551

Query: 753 PTASKIVTDSNSRVSEP 769
           P  +  V D   R   P
Sbjct: 552 PETAAPVEDMARRTKRP 568


>gi|23510413 sorting nexin 26 [Homo sapiens]
          Length = 1126

 Score =  125 bits (314), Expect = 2e-28
 Identities = 144/564 (25%), Positives = 220/564 (39%), Gaps = 85/564 (15%)

Query: 224 RKALAVLEKTLPEMRAHQDKWAEKP-----AFGTPLEEHLKRSGREIALPIEACVMLLLE 278
           R  LA L +T    R  + +  ++       FG  L EHL  SG+++   +  C   +  
Sbjct: 282 RGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEA 341

Query: 279 TGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDE-----FYSDPHAVAGALKSYLRELPE 333
            G+ + G++R+   +S +++L+   D  +  + E     F  D H+V+   K Y RELP 
Sbjct: 342 HGVVD-GIYRLSGVSSNIQRLRHEFD--SERIPELSGPAFLQDIHSVSSLCKLYFRELPN 398

Query: 334 PLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNK 393
           PL+T+ LY ++++  SV  ++++L  +    Q+LPP ++    YL++ LA++A+ S    
Sbjct: 399 PLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTS 458

Query: 394 MTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHV---VAVIEPIIQHADWFFPEEVEFNV 450
           M   N+AIV  PNLL +    ++    AA    V     V+E ++ H D  F        
Sbjct: 459 MHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF-------- 510

Query: 451 SEAFVPLTTPSSNHSFHTGNDSDSGTLERKR----PASMAVMEGDLVKKESPPKPKDPVS 506
           S+ F       +         S +G+    R      + A  +G L     P  PK P S
Sbjct: 511 SDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPAS 570

Query: 507 AAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAP------ 560
            A    G    +    Q +P  ++     ++G+     GPS        KKP P      
Sbjct: 571 PAERRKGERGEK----QRKPGGSSWKTFFALGR-----GPSVPR-----KKPLPWLGGTR 616

Query: 561 APPKPGNPPP---------------GHPGGQSSSGTSQHPPSLSPKP---PTRSPSP--- 599
           APP+P    P                   G    G    P S +P P   P RS  P   
Sbjct: 617 APPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASATPTPALSPGRSLRPHLI 676

Query: 600 PTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPN 659
           P    G       AP   +  +   S L   Q P  P  + P    PL   +P    PP 
Sbjct: 677 PLLLRG-----AEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPP 731

Query: 660 P------MALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHA 713
           P      MAL      +Q +    Q      TPP   Q+P   +     GG P      +
Sbjct: 732 PKNPARLMALALAERAQQVAEQQSQQEC-GGTPP-ASQSPFHRSLSLEVGGEPLGT---S 786

Query: 714 GTLPRPRPVPKPRNRPSVPPPPQP 737
           G+ P P  +  P      PPP  P
Sbjct: 787 GSGPPPNSLAHPGAWVPGPPPYLP 810



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 64/257 (24%), Positives = 95/257 (36%), Gaps = 20/257 (7%)

Query: 489  EGDLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSP 548
            +G L++ +   +P       +  P + ++Q+ +G     A   + Q     P     P+P
Sbjct: 815  DGSLLRSQ---RPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSPCSVPSQV--PTP 869

Query: 549  HTLRRAVKKPAP---APPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTG 605
                 A ++  P     PKPG  P G P  Q SS       SL P  P           G
Sbjct: 870  GFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLDRGENLYYEIG 929

Query: 606  QPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPN--SQGPPNPMAL 663
               G P      S P R  S    +              +P +H  P+     PP P   
Sbjct: 930  ASEGSP-----YSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCF 984

Query: 664  PSEH-GLEQPSHTPPQTPTPPSTPPLG-KQNPSLPAPQTLAGGNPETAQPHAGTLPRPRP 721
            P +H G   P H P + PTPP    +     P  P+P + +  +P  A P + + P P P
Sbjct: 985  PPDHLGYSAPQH-PARRPTPPEPLYVNLALGPRGPSPASSSSSSP-PAHPRSRSDPGP-P 1041

Query: 722  VPKPRNRPSVPPPPQPP 738
            VP+   +   P  P+ P
Sbjct: 1042 VPRLPQKQRAPWGPRTP 1058



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 52/186 (27%), Positives = 71/186 (38%), Gaps = 30/186 (16%)

Query: 566  GNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSS 625
            G  PP H   +S      +PP+ S  PP        QH   P  +P+ P  L        
Sbjct: 962  GQSPPLH---RSPDFLLSYPPAPSCFPPDHLGYSAPQH---PARRPTPPEPLY------- 1008

Query: 626  SLSPIQAPNHPPPQPPTQATPLMHTKPNSQ-GPPNPMALPSEHGLEQPSHTPPQTPTPPS 684
             ++    P  P P   + ++P  H +  S  GPP P  LP +        TP + P P  
Sbjct: 1009 -VNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVP-RLPQKQRAPWGPRTPHRVPGPWG 1066

Query: 685  TP-PLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPP---GV 740
             P PL     + PA     GG     + H G+L R       R   + PPPP P     +
Sbjct: 1067 PPEPLLLYRAAPPAYG--RGG-----ELHRGSLYRN---GGQRGEGAGPPPPYPTPSWSL 1116

Query: 741  HSAGDS 746
            HS G +
Sbjct: 1117 HSEGQT 1122



 Score = 30.8 bits (68), Expect = 5.2
 Identities = 32/129 (24%), Positives = 42/129 (32%), Gaps = 24/129 (18%)

Query: 501  PKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAP 560
            P+ P     P P      +A G   P  A+ S       P + + P P   R   K+ AP
Sbjct: 994  PQHPARRPTP-PEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAP 1052

Query: 561  -------------APPKP-----GNPPPGHPGGQSSSGT-----SQHPPSLSPKPPTRSP 597
                          PP+P       PP    GG+   G+      Q      P PP  +P
Sbjct: 1053 WGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTP 1112

Query: 598  SPPTQHTGQ 606
            S      GQ
Sbjct: 1113 SWSLHSEGQ 1121


>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
           sapiens]
          Length = 655

 Score =  117 bits (294), Expect = 3e-26
 Identities = 72/207 (34%), Positives = 118/207 (57%), Gaps = 8/207 (3%)

Query: 247 KPAFGTPLEEHL---KRSGREIA-LPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAA 302
           K  FG  LE+ +   KR G  +A + +E CV  + + G+KEEGLFR+   A+ +K+L+ A
Sbjct: 37  KGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDA 96

Query: 303 LDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASV--QDQDKKLQDL 360
            DC      +  +D H VA  LK YLRELPEP++ +  YE++   A +  ++++  +++L
Sbjct: 97  FDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKEL 156

Query: 361 WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA 420
            +  + LP  N+   +Y+ +FL ++   S VNKM+  N+A V GPN+L  + E  L  M 
Sbjct: 157 AKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIME 216

Query: 421 AATSVHVVAVIEPIIQHADWFFPEEVE 447
              +V V  ++  +I   D  FP++ E
Sbjct: 217 G--TVVVQQLMSVMISKHDCLFPKDAE 241


>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
           sapiens]
          Length = 653

 Score =  117 bits (292), Expect = 6e-26
 Identities = 71/204 (34%), Positives = 117/204 (57%), Gaps = 8/204 (3%)

Query: 250 FGTPLEEHL---KRSGREIA-LPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDC 305
           FG  LE+ +   KR G  +A + +E CV  + + G+KEEGLFR+   A+ +K+L+ A DC
Sbjct: 38  FGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDC 97

Query: 306 STSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASV--QDQDKKLQDLWRT 363
                 +  +D H VA  LK YLRELPEP++ +  YE++   A +  ++++  +++L + 
Sbjct: 98  GEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQ 157

Query: 364 CQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAAT 423
            + LP  N+   +Y+ +FL ++   S VNKM+  N+A V GPN+L  + E  L  M    
Sbjct: 158 VKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEG-- 215

Query: 424 SVHVVAVIEPIIQHADWFFPEEVE 447
           +V V  ++  +I   D  FP++ E
Sbjct: 216 TVVVQQLMSVMISKHDCLFPKDAE 239


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score =  117 bits (292), Expect = 6e-26
 Identities = 71/204 (34%), Positives = 117/204 (57%), Gaps = 8/204 (3%)

Query: 250 FGTPLEEHL---KRSGREIA-LPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDC 305
           FG  LE+ +   KR G  +A + +E CV  + + G+KEEGLFR+   A+ +K+L+ A DC
Sbjct: 133 FGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDC 192

Query: 306 STSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASV--QDQDKKLQDLWRT 363
                 +  +D H VA  LK YLRELPEP++ +  YE++   A +  ++++  +++L + 
Sbjct: 193 GEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQ 252

Query: 364 CQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAAT 423
            + LP  N+   +Y+ +FL ++   S VNKM+  N+A V GPN+L  + E  L  M    
Sbjct: 253 VKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEG-- 310

Query: 424 SVHVVAVIEPIIQHADWFFPEEVE 447
           +V V  ++  +I   D  FP++ E
Sbjct: 311 TVVVQQLMSVMISKHDCLFPKDAE 334


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score =  114 bits (285), Expect = 4e-25
 Identities = 73/199 (36%), Positives = 113/199 (56%), Gaps = 9/199 (4%)

Query: 250 FGTPLEE---HLKRSGREIA-LPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDC 305
           FG  LEE   H ++ G  +A L +E CV  + E G+ EEGLFR+   A+ ++ L+ + DC
Sbjct: 153 FGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDC 212

Query: 306 STSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASV--QDQDKKLQDLWRT 363
               L +  +D H VA  LK YLRELPEP++ F  YE++   A +  +D+ +   +L + 
Sbjct: 213 GEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQ 272

Query: 364 CQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAAT 423
              LP  N+   RY+ KFL ++   S+VNKM+  N+A V GPN+L  + E  +  M   +
Sbjct: 273 VSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTS 332

Query: 424 SV-HVVAVIEPIIQHADWF 441
            V H++ V+  I +H+  F
Sbjct: 333 LVQHLMTVL--IRKHSQLF 349


>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
          Length = 2087

 Score =  108 bits (269), Expect = 3e-23
 Identities = 65/221 (29%), Positives = 112/221 (50%), Gaps = 11/221 (4%)

Query: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
           FG  L EHL  SG E+   +++C   +   G+ + G++R+   AS +++L+   D  + H
Sbjct: 370 FGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFD--SEH 426

Query: 310 LDEFYSDP-----HAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTC 364
           + +   +P     H+V    K Y RELP PL+T+ LYE+++   S    +++L  +    
Sbjct: 427 VPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVI 486

Query: 365 QKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAR--NEGTLAEMAAA 422
           Q+LPP ++    +L++ L+ LA    +  M   N+AIV  PNLL ++       +  AA 
Sbjct: 487 QQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAF 546

Query: 423 TSVHVVA-VIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSS 462
             V + + V+E I+ H D  F   +   + E    L+ P S
Sbjct: 547 MEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKS 587



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 55/219 (25%), Positives = 80/219 (36%), Gaps = 30/219 (13%)

Query: 560  PAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRS----PSPPTQHTGQPPGQPSAPS 615
            P P       P H    + SG   H   L+   P ++         + T  P     +  
Sbjct: 1120 PLPETTATGDPTH-SNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDD 1178

Query: 616  QLSAPRRYSS-----SLSPIQAPNHPP-----PQPPT----QATPLMHTKPNSQGPPNPM 661
             +S P   S      ++S +     PP      QPP+        L H    +   P P 
Sbjct: 1179 HVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPP 1238

Query: 662  ALPSEHGLEQPSHTPPQ-----TPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTL 716
             LPS+  +  PS +P +     T T  +T P   Q  +  A   +A   P TA   A TL
Sbjct: 1239 NLPSDK-IYPPSGSPEENTSTATMTYMTTTPATAQMSTKEASWDVAE-QPTTADFAAATL 1296

Query: 717  PRP----RPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNT 751
             R     RP+P P ++ S   PP    V +A +  L N+
Sbjct: 1297 QRTHRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNS 1335



 Score = 33.9 bits (76), Expect = 0.62
 Identities = 61/293 (20%), Positives = 96/293 (32%), Gaps = 43/293 (14%)

Query: 458  TTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESPPKPK-----DPVSAAVPAP 512
            TT  +  S ++    D    +  RPA    ++ +       P P+     DP  +     
Sbjct: 1079 TTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTES 1138

Query: 513  GRNNSQIASGQNQPQAAAGSHQLSMGQ-----------------PHNAAGP-SPHTLRRA 554
            G  + Q+    NQP  A  S      +                 P + +G  S  T+   
Sbjct: 1139 GEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFL 1198

Query: 555  VKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAP 614
             +  +P     G+ PP + G  +S     HP   + K PT  P+ P+     P G P   
Sbjct: 1199 DQDQSPPRFYSGDQPPSYLG--ASVDKLHHPLEFADKSPT-PPNLPSDKIYPPSGSPEEN 1255

Query: 615  SQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQG-PPNPMALPSEHGLEQPS 673
            +  +A   Y ++               T AT  M TK  S      P          Q +
Sbjct: 1256 TS-TATMTYMTT---------------TPATAQMSTKEASWDVAEQPTTADFAAATLQRT 1299

Query: 674  HTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPR 726
            H   +   PP +    +Q P +   Q         +    G +P P   P+PR
Sbjct: 1300 HRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNSHKVQGVVPVPERPPEPR 1352


>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
          Length = 1738

 Score =  108 bits (269), Expect = 3e-23
 Identities = 65/221 (29%), Positives = 112/221 (50%), Gaps = 11/221 (4%)

Query: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
           FG  L EHL  SG E+   +++C   +   G+ + G++R+   AS +++L+   D  + H
Sbjct: 21  FGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFD--SEH 77

Query: 310 LDEFYSDP-----HAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTC 364
           + +   +P     H+V    K Y RELP PL+T+ LYE+++   S    +++L  +    
Sbjct: 78  VPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVI 137

Query: 365 QKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAR--NEGTLAEMAAA 422
           Q+LPP ++    +L++ L+ LA    +  M   N+AIV  PNLL ++       +  AA 
Sbjct: 138 QQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAF 197

Query: 423 TSVHVVA-VIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSS 462
             V + + V+E I+ H D  F   +   + E    L+ P S
Sbjct: 198 MEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKS 238



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 55/219 (25%), Positives = 80/219 (36%), Gaps = 30/219 (13%)

Query: 560 PAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRS----PSPPTQHTGQPPGQPSAPS 615
           P P       P H    + SG   H   L+   P ++         + T  P     +  
Sbjct: 771 PLPETTATGDPTH-SNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDD 829

Query: 616 QLSAPRRYSS-----SLSPIQAPNHPP-----PQPPT----QATPLMHTKPNSQGPPNPM 661
            +S P   S      ++S +     PP      QPP+        L H    +   P P 
Sbjct: 830 HVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPP 889

Query: 662 ALPSEHGLEQPSHTPPQ-----TPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTL 716
            LPS+  +  PS +P +     T T  +T P   Q  +  A   +A   P TA   A TL
Sbjct: 890 NLPSDK-IYPPSGSPEENTSTATMTYMTTTPATAQMSTKEASWDVAE-QPTTADFAAATL 947

Query: 717 PRP----RPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNT 751
            R     RP+P P ++ S   PP    V +A +  L N+
Sbjct: 948 QRTHRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNS 986



 Score = 33.9 bits (76), Expect = 0.62
 Identities = 61/293 (20%), Positives = 96/293 (32%), Gaps = 43/293 (14%)

Query: 458  TTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESPPKPK-----DPVSAAVPAP 512
            TT  +  S ++    D    +  RPA    ++ +       P P+     DP  +     
Sbjct: 730  TTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTES 789

Query: 513  GRNNSQIASGQNQPQAAAGSHQLSMGQ-----------------PHNAAGP-SPHTLRRA 554
            G  + Q+    NQP  A  S      +                 P + +G  S  T+   
Sbjct: 790  GEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFL 849

Query: 555  VKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAP 614
             +  +P     G+ PP + G  +S     HP   + K PT  P+ P+     P G P   
Sbjct: 850  DQDQSPPRFYSGDQPPSYLG--ASVDKLHHPLEFADKSPT-PPNLPSDKIYPPSGSPEEN 906

Query: 615  SQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQG-PPNPMALPSEHGLEQPS 673
            +  +A   Y ++               T AT  M TK  S      P          Q +
Sbjct: 907  TS-TATMTYMTT---------------TPATAQMSTKEASWDVAEQPTTADFAAATLQRT 950

Query: 674  HTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPR 726
            H   +   PP +    +Q P +   Q         +    G +P P   P+PR
Sbjct: 951  HRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNSHKVQGVVPVPERPPEPR 1003


>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
           sapiens]
          Length = 890

 Score =  107 bits (267), Expect = 4e-23
 Identities = 128/523 (24%), Positives = 200/523 (38%), Gaps = 95/523 (18%)

Query: 245 AEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALD 304
           A++  FG  L+EHL+ SG+E+   +++C   + E G+ + G++R+   +S ++KL+   +
Sbjct: 13  AKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEFE 71

Query: 305 CSTS---HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLW 361
                    D +  D H V+   K+Y RELP+PL+T+ LY+++ +   VQ + ++L  + 
Sbjct: 72  SERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKIL 131

Query: 362 RTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN------EGT 415
              ++LP  N+    +L++ L  +A  S    M   N+AIV  PNLL +++       GT
Sbjct: 132 EVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191

Query: 416 LAEMAAATSVHVVAVIEPIIQHADWFF------------------------------PEE 445
            A M          V+E I+ H D  F                              P  
Sbjct: 192 AAFMEVRVQ---SIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRP 248

Query: 446 VEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEG----DLVKKESPPKP 501
           + +++         P     +HT  +      E KR  S+ V +     +L +     K 
Sbjct: 249 LPYHLPSILQAGDGPPQMRPYHTIIE----IAEHKRKGSLKVRKWRSIFNLGRSGHETKR 304

Query: 502 KDPVSAAVPAPGRNNSQI--ASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPA 559
           K P  A       N   +  A   +   AAAG+      +P    GPS          P 
Sbjct: 305 KLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASD----EPEGLVGPS---------SPR 351

Query: 560 PAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSA 619
           P+P  P          +S    S        +P   +       T   PG P A    SA
Sbjct: 352 PSPLLP----------ESLENDSIEAAEGEQEPEAEA----LGGTNSEPGTPRAGR--SA 395

Query: 620 PRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPS----EHGLEQPS-- 673
            R   SS +   A  H     P      +H       PPN ++  S      GLE P+  
Sbjct: 396 IRAGGSSRAERCAGVH--ISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECPALQ 453

Query: 674 HTPPQTPTPPSTPPLGKQNP-----SLPAPQTLAGGNPETAQP 711
           H P     P   P LG   P     + PA   LA   P+   P
Sbjct: 454 HRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAP 496


>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
           sapiens]
          Length = 1101

 Score =  107 bits (267), Expect = 4e-23
 Identities = 128/523 (24%), Positives = 200/523 (38%), Gaps = 95/523 (18%)

Query: 245 AEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALD 304
           A++  FG  L+EHL+ SG+E+   +++C   + E G+ + G++R+   +S ++KL+   +
Sbjct: 13  AKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQKLRQEFE 71

Query: 305 CSTS---HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLW 361
                    D +  D H V+   K+Y RELP+PL+T+ LY+++ +   VQ + ++L  + 
Sbjct: 72  SERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKIL 131

Query: 362 RTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN------EGT 415
              ++LP  N+    +L++ L  +A  S    M   N+AIV  PNLL +++       GT
Sbjct: 132 EVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGT 191

Query: 416 LAEMAAATSVHVVAVIEPIIQHADWFF------------------------------PEE 445
            A M          V+E I+ H D  F                              P  
Sbjct: 192 AAFMEVRVQ---SIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLMPRP 248

Query: 446 VEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEG----DLVKKESPPKP 501
           + +++         P     +HT  +      E KR  S+ V +     +L +     K 
Sbjct: 249 LPYHLPSILQAGDGPPQMRPYHTIIE----IAEHKRKGSLKVRKWRSIFNLGRSGHETKR 304

Query: 502 KDPVSAAVPAPGRNNSQI--ASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPA 559
           K P  A       N   +  A   +   AAAG+      +P    GPS          P 
Sbjct: 305 KLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASD----EPEGLVGPS---------SPR 351

Query: 560 PAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSA 619
           P+P  P          +S    S        +P   +       T   PG P A    SA
Sbjct: 352 PSPLLP----------ESLENDSIEAAEGEQEPEAEA----LGGTNSEPGTPRAGR--SA 395

Query: 620 PRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPS----EHGLEQPS-- 673
            R   SS +   A  H     P      +H       PPN ++  S      GLE P+  
Sbjct: 396 IRAGGSSRAERCAGVH--ISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECPALQ 453

Query: 674 HTPPQTPTPPSTPPLGKQNP-----SLPAPQTLAGGNPETAQP 711
           H P     P   P LG   P     + PA   LA   P+   P
Sbjct: 454 HRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAP 496


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  106 bits (265), Expect = 7e-23
 Identities = 83/361 (22%), Positives = 153/361 (42%), Gaps = 28/361 (7%)

Query: 241  QDKWAEKPAFGTPLEE-HLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKL 299
            ++K A   AFG  LEE       + + L + AC  ++   G++  G++R+    + +  L
Sbjct: 800  KNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSL 859

Query: 300  KAALDCSTSHL---DEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKK 356
            +  L+     +   DE + D + ++  LKS+ R+LPEPL T + Y ++ +   ++D  ++
Sbjct: 860  QEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARER 919

Query: 357  LQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTL 416
            ++ L +  + LP   +   ++L+  L  +A  S+ NKM P N+A+V GP L+   +E  +
Sbjct: 920  MRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLV-RTSEDNM 978

Query: 417  AEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAF----------VPLTTPSSNHSF 466
             +M          ++E +IQH+DWFF +E +                 +    P+   + 
Sbjct: 979  TDMVTHMPDR-YKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTV 1037

Query: 467  HTGNDSDSGTLERKRPASMAVMEGDLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQP 526
              G+     T       S A  +G    K+ P   +    + + A  R   +    +   
Sbjct: 1038 PPGDPGSDST-----TCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLG 1092

Query: 527  QAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPP 586
             +     +    +P  A   +P T  R      P  P PG   P  PG  S     +  P
Sbjct: 1093 SSTDDDSEQEAHKP-GAGATAPGTQER------PQGPLPGAVAPEAPGRLSPPAAPEERP 1145

Query: 587  S 587
            +
Sbjct: 1146 A 1146



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 27/121 (22%), Positives = 44/121 (36%), Gaps = 7/121 (5%)

Query: 607  PPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSE 666
            PPG P + S   +  +   S +P + P +            ++ K   +     +   ++
Sbjct: 1038 PPGDPGSDSTTCSSAKSKGSWAPKKEP-YAREMLAISFISAVNRKRKKRREARGLGSSTD 1096

Query: 667  HGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPR 726
               EQ +H P    T P T    ++ P  P P  +A   P    P A   P  RP    R
Sbjct: 1097 DDSEQEAHKPGAGATAPGT----QERPQGPLPGAVAPEAPGRLSPPAA--PEERPAADTR 1150

Query: 727  N 727
            +
Sbjct: 1151 S 1151


>gi|4505507 oligophrenin 1 [Homo sapiens]
          Length = 802

 Score =  104 bits (260), Expect = 3e-22
 Identities = 101/398 (25%), Positives = 166/398 (41%), Gaps = 58/398 (14%)

Query: 246 EKPAFGTPLEEHLKRSGREIALP-IEACVMLLLETGMKEEGLFR-IGAGASKLKKLKAAL 303
           ++P + +P+ +  +    E+    +  C+ ++   G+K EGL+R +G+     K L A  
Sbjct: 366 KEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFF 425

Query: 304 DCSTSHLDEFYS---DPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL 360
           D       +F++   D   +  +LK YLR L EP+MT+ L++E    A   + D +L  +
Sbjct: 426 DPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAI 485

Query: 361 WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA 420
                KLP +N      LI+ L  + + S  N MTPSN+ ++ GP L+ A+ E T+A M 
Sbjct: 486 HSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQ-EDTVAAMM 544

Query: 421 AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHS--------------F 466
                ++  V+E +I+H    +    E + +    P    +  H               F
Sbjct: 545 NIKFQNI--VVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVF 602

Query: 467 HTGN-DSDSGTLERKRPASMAVMEGDLVKKESPPK----PKDPVS-AAVPAPGRNNSQ-- 518
           +T + D     ++ + P       G +     PPK    PK P+  +    PGR +    
Sbjct: 603 YTSSLDESEDEIQHQTP------NGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRP 656

Query: 519 IASGQNQPQAAAGSHQL--------SMGQPHNAAGPSP-----HTLRRAVKKPAPAPPKP 565
           I  G+ +P       +L        +   P    GP P      T    +K+PAP     
Sbjct: 657 ILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAP----- 711

Query: 566 GNPPPGHPGGQSSSGTSQHPPSLSP---KPPTRSPSPP 600
             P   H  G + S +   PP   P   +PP R P PP
Sbjct: 712 -RPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPP 748



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 37/146 (25%), Positives = 54/146 (36%), Gaps = 31/146 (21%)

Query: 587 SLSPKPPTRSPSPPTQHTGQ-PPGQ--PSAP---------------SQLSAPRRYSSSLS 628
           S+ P  P + P  P Q +G+  PG+  PS P                 +S  +   + ++
Sbjct: 626 SIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKIT 685

Query: 629 PIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPP--------QTP 680
           P +A N P P      TP  H K   +  P P+A   E   +  S   P        + P
Sbjct: 686 P-KATNGPMPGSGPTKTPSFHIK---RPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPP 741

Query: 681 TPPSTPPLGKQNPSLPAPQ-TLAGGN 705
             P  PP     P  P P+  +  GN
Sbjct: 742 VRPPDPPCRAATPQKPEPKPDIVAGN 767


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score =  102 bits (254), Expect = 1e-21
 Identities = 66/200 (33%), Positives = 105/200 (52%), Gaps = 7/200 (3%)

Query: 249 AFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAAL---DC 305
           AFG  L E+L+ SG+++   +++C   + ET    +G++R+    S +++L+       C
Sbjct: 18  AFGCDLTEYLESSGQDVPYVLKSCAEFI-ETHGIVDGIYRLSGVTSNIQRLRQEFGSDQC 76

Query: 306 STSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQ 365
                + +  D H V    K Y RELP PL+T+ LYE++T+  S   ++ +L  +    Q
Sbjct: 77  PDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQ 136

Query: 366 KLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN-EGTLAE-MAAAT 423
           +LPP ++    YLI+ LA +A  S    M   N+A+V  PNLL ++  E T     AA  
Sbjct: 137 ELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFL 196

Query: 424 SVHV-VAVIEPIIQHADWFF 442
           +V V   VIE I+ H D  F
Sbjct: 197 AVRVQQVVIEFILNHVDQIF 216



 Score = 34.3 bits (77), Expect = 0.47
 Identities = 25/104 (24%), Positives = 43/104 (41%), Gaps = 9/104 (8%)

Query: 573 PGGQSSSGTSQHPPSLSPKP-----PTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSL 627
           P  QS+ G S       P+P     P  +   P +        P A  ++  P     +L
Sbjct: 722 PANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGP----GNL 777

Query: 628 SPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQ 671
           SP   P  PPP P  ++TP++ +K   +   +   L ++  ++Q
Sbjct: 778 SPPLPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQ 821


>gi|21314774 T-cell activation Rho GTPase-activating protein isoform
           b [Homo sapiens]
          Length = 731

 Score =  102 bits (253), Expect = 2e-21
 Identities = 80/310 (25%), Positives = 135/310 (43%), Gaps = 28/310 (9%)

Query: 268 PIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSY 327
           PI+  + +L   G   EG+FR  A     K+LK  L+ S   +D      H +A   K +
Sbjct: 103 PIQDILTILCLKGPSTEGIFRRAANEKARKELKEELN-SGDAVDLERLPVHLLAVVFKDF 161

Query: 328 LRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQ 387
           LR +P  L++ +L+EEW     +QD++ +++ L +   KLP  N +  ++L+  L  +++
Sbjct: 162 LRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISK 221

Query: 388 TSDVNKMTPSNIAIVLGPNLLWARNEGTLA-EMAAATSVHVVAVIEPIIQHADWFFPEEV 446
            S+VN+M  SN+AI +GPN+L   N+ +L+ E     +  V  ++E +I +    F E +
Sbjct: 222 NSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEIFGENI 281

Query: 447 EFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESPPKPKDPVS 506
                            HS  T +DS    LE    + ++ ++ D     + P  +   S
Sbjct: 282 PV---------------HSSITSDDS----LEHTDSSDVSTLQNDSAYDSNDPDVESNSS 322

Query: 507 AAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPG 566
           + + +P R           P A A     +  Q      P P     A  K + A P   
Sbjct: 323 SGISSPSRQ-------PQVPMATAAGLDSAGPQDAREVSPEPIVSTVARLKSSLAQPDRR 375

Query: 567 NPPPGHPGGQ 576
              P  P  Q
Sbjct: 376 YSEPSMPSSQ 385


>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
          Length = 1502

 Score =  100 bits (250), Expect = 4e-21
 Identities = 62/198 (31%), Positives = 107/198 (54%), Gaps = 5/198 (2%)

Query: 246  EKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDC 305
            E   FG PL++ L  + + I L +E CV  + +TG+  EGL+R+    +    ++   D 
Sbjct: 1256 ESNYFGMPLQD-LVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQ 1314

Query: 306  STS-HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTC 364
              + +L       +AVAGALK++  +LP+PL+ ++L+ E  + A + D+ ++L  L    
Sbjct: 1315 DHNINLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIV 1374

Query: 365  QKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATS 424
            +K  P N+  FRY+I  L +++Q   +N MT  N++I   P L+  R +    E  + T 
Sbjct: 1375 KKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLM--RPDFENREFLSTTK 1432

Query: 425  VHVVAVIEPIIQHADWFF 442
            +H  +V+E  IQ   +FF
Sbjct: 1433 IH-QSVVETFIQQCQFFF 1449


>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
          Length = 1501

 Score =  100 bits (250), Expect = 4e-21
 Identities = 62/198 (31%), Positives = 107/198 (54%), Gaps = 5/198 (2%)

Query: 246  EKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDC 305
            E   FG PL++ L  + + I L +E CV  + +TG+  EGL+R+    +    ++   D 
Sbjct: 1255 ESNYFGMPLQD-LVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQ 1313

Query: 306  STS-HLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTC 364
              + +L       +AVAGALK++  +LP+PL+ ++L+ E  + A + D+ ++L  L    
Sbjct: 1314 DHNINLVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIV 1373

Query: 365  QKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATS 424
            +K  P N+  FRY+I  L +++Q   +N MT  N++I   P L+  R +    E  + T 
Sbjct: 1374 KKFHPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLM--RPDFENREFLSTTK 1431

Query: 425  VHVVAVIEPIIQHADWFF 442
            +H  +V+E  IQ   +FF
Sbjct: 1432 IH-QSVVETFIQQCQFFF 1448


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score =  100 bits (249), Expect = 5e-21
 Identities = 61/202 (30%), Positives = 105/202 (51%), Gaps = 11/202 (5%)

Query: 261  SGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLD---EFYSDP 317
            + R I L ++ C  L+ E G++  G++R+    + +  ++  L+   + +D   + + D 
Sbjct: 1157 TNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDL 1216

Query: 318  HAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRY 377
            + ++  LKS+ R+LPEPL T + Y ++ +    +D   +L+ L R    LP  ++   ++
Sbjct: 1217 NVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKF 1276

Query: 378  LIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQH 437
            L   L  +A+ S+ NKM P N+AIV GP L+   +E  +  M          ++E +IQH
Sbjct: 1277 LSAHLKTVAENSEKNKMEPRNLAIVFGPTLV-RTSEDNMTHMVTHMP-DQYKIVETLIQH 1334

Query: 438  ADWFFPEEVEFNVSEAFVPLTT 459
             DWFF EE       A  PLTT
Sbjct: 1335 HDWFFTEE------GAEEPLTT 1350


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 61/203 (30%), Positives = 104/203 (51%), Gaps = 8/203 (3%)

Query: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
           FG  +    KR   ++   +  CV  + + G++E G++RI   A+ ++ LKA  D +   
Sbjct: 599 FGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKD 658

Query: 310 LDEFYSDP--HAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKL 367
           +    SD   +A+AG LK Y RELPEPL+T  LY  + +  ++ D   K   +    + L
Sbjct: 659 ILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSL 718

Query: 368 PPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSV-- 425
           P  N + F +L++ L ++A+   +NKM+  N+A V GP LL      + A + +A  +  
Sbjct: 719 PDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWS 778

Query: 426 -HVVAVIEPI---IQHADWFFPE 444
             V+A ++ +   +QH    F E
Sbjct: 779 HDVMAQVQVLLYYLQHPPISFAE 801


>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
            sapiens]
          Length = 1499

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 73/268 (27%), Positives = 127/268 (47%), Gaps = 21/268 (7%)

Query: 246  EKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDC 305
            E   FG PL   +    + I + IE C+  +  TG+  EG++R+    S+++ L+   D 
Sbjct: 1243 ESNYFGVPLTTVVTPE-KPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFD- 1300

Query: 306  STSHLDEFYSD--PHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRT 363
               +LD    D   + VAGA+KS+  ELP+PL+ +N+  +  +   + D+++KL  L   
Sbjct: 1301 QDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEV 1360

Query: 364  CQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAAT 423
             +K P +N   F+Y+I  L K++  + VN MT  N++I   P L+  R + +  +   AT
Sbjct: 1361 LKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLM--RPDFSTMDALTAT 1418

Query: 424  SVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPA 483
              +   +IE  IQ   +FF     +N      P   PSS  +  +     + T    +P+
Sbjct: 1419 RTY-QTIIELFIQQCPFFF-----YNRPITEPPGARPSSPSAVASTVPFLTSTPVTSQPS 1472

Query: 484  SMAVMEGDLVKKESPPKPKDPVSAAVPA 511
                       +  PP P+ P+   +P+
Sbjct: 1473 P---------PQSPPPTPQSPMQPLLPS 1491



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 24/58 (41%), Positives = 27/58 (46%), Gaps = 3/58 (5%)

Query: 564  KPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQH--TGQPPGQPSAPSQLSA 619
            +P   PPG     S S  +   P L+  P T  PSPP     T Q P QP  PSQL A
Sbjct: 1439 RPITEPPG-ARPSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTPQSPMQPLLPSQLQA 1495



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 9/65 (13%)

Query: 606  QPPG-QPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALP 664
            +PPG +PS+PS +++   + +S      P+ P   PPT  +P+         P  P  L 
Sbjct: 1443 EPPGARPSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTPQSPMQ--------PLLPSQLQ 1494

Query: 665  SEHGL 669
            +EH L
Sbjct: 1495 AEHTL 1499


>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
          Length = 1136

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 67/248 (27%), Positives = 112/248 (45%), Gaps = 27/248 (10%)

Query: 223 HRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMK 282
           H+K L    +TL     H+        FG       + +   +   ++ CV  +    ++
Sbjct: 736 HKKCL----ETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALR 791

Query: 283 EEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYE 342
            +G++R+    ++++KL  A +     ++   + PH ++  LK YLR+LPEPL++F LY 
Sbjct: 792 TKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYH 851

Query: 343 EWTQV--------ASVQDQDKKLQD--------------LWRTCQKLPPQNFVNFRYLIK 380
           E   +        A  +   +  QD              L    + LPP+N  + +YL++
Sbjct: 852 ELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLR 911

Query: 381 FLAKLAQTSDVNKMTPSNIAIVLGPNLLWAR-NEGTLAEMAAATSVHVVAVIEPIIQHAD 439
            L ++ +    NKMTP N+ IV GP LL  R  E T++  +     H   VIE +I H  
Sbjct: 912 HLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYG 971

Query: 440 WFFPEEVE 447
             F EE E
Sbjct: 972 LVFEEEPE 979


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 61/203 (30%), Positives = 104/203 (51%), Gaps = 8/203 (3%)

Query: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
           FG  +    KR   ++   +  CV  + + G++E G++RI   A+ ++ LKA  D +   
Sbjct: 645 FGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKD 704

Query: 310 LDEFYSDP--HAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKL 367
           +    SD   +A+AG LK Y RELPEPL+T  LY  + +  ++ D   K   +    + L
Sbjct: 705 ILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSL 764

Query: 368 PPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSV-- 425
           P  N + F +L++ L ++A+   +NKM+  N+A V GP LL      + A + +A  +  
Sbjct: 765 PDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWS 824

Query: 426 -HVVAVIEPI---IQHADWFFPE 444
             V+A ++ +   +QH    F E
Sbjct: 825 HDVMAQVQVLLYYLQHPPISFAE 847


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 61/203 (30%), Positives = 104/203 (51%), Gaps = 8/203 (3%)

Query: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
           FG  +    KR   ++   +  CV  + + G++E G++RI   A+ ++ LKA  D +   
Sbjct: 608 FGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKD 667

Query: 310 LDEFYSDP--HAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKL 367
           +    SD   +A+AG LK Y RELPEPL+T  LY  + +  ++ D   K   +    + L
Sbjct: 668 ILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSL 727

Query: 368 PPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSV-- 425
           P  N + F +L++ L ++A+   +NKM+  N+A V GP LL      + A + +A  +  
Sbjct: 728 PDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWS 787

Query: 426 -HVVAVIEPI---IQHADWFFPE 444
             V+A ++ +   +QH    F E
Sbjct: 788 HDVMAQVQVLLYYLQHPPISFAE 810


>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
           sapiens]
          Length = 645

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 107/459 (23%), Positives = 182/459 (39%), Gaps = 72/459 (15%)

Query: 181 DEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH 240
           DE   K + C       +        E GKF   ++ A  D +R         +   +A 
Sbjct: 80  DEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYV-LMASSQAE 138

Query: 241 QDKWAE--KPAFGTPLEEHLKRSGREIA-----------LPIEACVMLLLETGMKEEGLF 287
            ++W +  +   GTP     +R    +A           + +E C   +LE G  EEG+F
Sbjct: 139 MEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEHGRNEEGIF 198

Query: 288 RIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQV 347
           R+    + +K+L+ A D       +  +D H VA  LK YLR+LPEP++ ++ YE +   
Sbjct: 199 RLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLC 258

Query: 348 ASV--QDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGP 405
             +   D+ K  Q+L +    LP  N+    Y+ +FL ++     VNKM+  N+A V+G 
Sbjct: 259 GQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGV 318

Query: 406 NLLWARNEGTLAEMAAATSVHVVAV-----------------IEPIIQHAD--------- 439
           NL+ ++ E     M     +  V                   + P  Q  D         
Sbjct: 319 NLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQKNDPKKAPVARS 378

Query: 440 ---WFFPEEVEFNVSEAFVPLTTPSSNHSFHTGND------SDSGTLERKRPASMAVMEG 490
              W   E++  + +++F  +T+ S   S  TG         DS  + R++P    +   
Sbjct: 379 SVGWDATEDLRISRTDSFSSMTSDSDTTS-PTGQQPSDAFPEDSSKVPREKPGDWKMQS- 436

Query: 491 DLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQ-----PQAAAG-SHQLSMGQPHNAA 544
              +K +   P           G N+S++   +N+      +A AG  H+ +M Q     
Sbjct: 437 ---RKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQL 493

Query: 545 GPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQ 583
             S  T   +     P+        PG PG ++S+ +SQ
Sbjct: 494 SDSQRT---STYDNVPS-------LPGSPGEEASALSSQ 522


>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
           sapiens]
          Length = 638

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 107/459 (23%), Positives = 182/459 (39%), Gaps = 72/459 (15%)

Query: 181 DEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH 240
           DE   K + C       +        E GKF   ++ A  D +R         +   +A 
Sbjct: 73  DEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYV-LMASSQAE 131

Query: 241 QDKWAE--KPAFGTPLEEHLKRSGREIA-----------LPIEACVMLLLETGMKEEGLF 287
            ++W +  +   GTP     +R    +A           + +E C   +LE G  EEG+F
Sbjct: 132 MEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEHGRNEEGIF 191

Query: 288 RIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQV 347
           R+    + +K+L+ A D       +  +D H VA  LK YLR+LPEP++ ++ YE +   
Sbjct: 192 RLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLC 251

Query: 348 ASV--QDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGP 405
             +   D+ K  Q+L +    LP  N+    Y+ +FL ++     VNKM+  N+A V+G 
Sbjct: 252 GQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGV 311

Query: 406 NLLWARNEGTLAEMAAATSVHVVAV-----------------IEPIIQHAD--------- 439
           NL+ ++ E     M     +  V                   + P  Q  D         
Sbjct: 312 NLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQKNDPKKAPVARS 371

Query: 440 ---WFFPEEVEFNVSEAFVPLTTPSSNHSFHTGND------SDSGTLERKRPASMAVMEG 490
              W   E++  + +++F  +T+ S   S  TG         DS  + R++P    +   
Sbjct: 372 SVGWDATEDLRISRTDSFSSMTSDSDTTS-PTGQQPSDAFPEDSSKVPREKPGDWKMQS- 429

Query: 491 DLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQ-----PQAAAG-SHQLSMGQPHNAA 544
              +K +   P           G N+S++   +N+      +A AG  H+ +M Q     
Sbjct: 430 ---RKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQL 486

Query: 545 GPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQ 583
             S  T   +     P+        PG PG ++S+ +SQ
Sbjct: 487 SDSQRT---STYDNVPS-------LPGSPGEEASALSSQ 515


>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
          Length = 2157

 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 111/449 (24%), Positives = 180/449 (40%), Gaps = 66/449 (14%)

Query: 280  GMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFN 339
            G+  EGL+R    A++ ++L+ AL    + +       HA+ G LK +LRELPEPLMTF 
Sbjct: 1727 GLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMTFA 1786

Query: 340  LYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNI 399
             Y ++ +   + ++ ++L  ++   + LP  N  +   LI  L K+A   DVN+M+P  +
Sbjct: 1787 QYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGAL 1846

Query: 400  AIVLGPNLL-WARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFP------EEVEFNVSE 452
            AI+  P LL    N   L  M     + +   +E +I+     +        ++E   S 
Sbjct: 1847 AIIFAPCLLRCPDNSDPLTSMKDV--LKITTCVEMLIKEQMRKYKVKMEEISQLEAAESI 1904

Query: 453  AFVPLTTPSSNHSF--HTGNDSDSGTLERKRPASMAVMEGDL------------------ 492
            AF  L+    N  +    G  S    +  K P +  + E +L                  
Sbjct: 1905 AFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKE 1964

Query: 493  ---VKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPH 549
                + +S  + K+ ++  +P      S   +  ++  A+  S          + GP   
Sbjct: 1965 ILIERIQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESLLEERAGRGASEGP--- 2021

Query: 550  TLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSP--------KPPTRSPSPPT 601
                    PAPA P PG P P      S   T   PP   P        K P R+P  PT
Sbjct: 2022 --------PAPALPCPGAPTP------SPLPTVAAPPRRRPSSFVTVRVKTPRRTPIMPT 2067

Query: 602  QHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPM 661
             +   PPG PS   + +   R   + +P++    PP + P Q   +  T P +  P    
Sbjct: 2068 ANIKLPPGLPSHLPRWAPGAR--EAAAPVRR-REPPARRPDQIHSVYIT-PGADLPVQGA 2123

Query: 662  ALPSEH-----GLEQPSHTPPQTPTPPST 685
              P E      G ++    PP    PP++
Sbjct: 2124 LEPLEEDGQPPGAKRRYSDPPTYCLPPAS 2152


>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapiens]
          Length = 1085

 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 132/579 (22%), Positives = 215/579 (37%), Gaps = 94/579 (16%)

Query: 250  FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
            F   LE  +K SG+ I L +E+C+  +   G++ +G+FR+     ++  +K + +   + 
Sbjct: 504  FNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENP 563

Query: 310  L--DEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKL 367
            L  D+   D ++VAG LK Y R L  PL     + +      + +  ++   + +    L
Sbjct: 564  LADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTL 623

Query: 368  PPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHV 427
            P    +  RYL  FL  L+Q SD N M P N+AI  GP L+         +   +   HV
Sbjct: 624  PRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPE----IQDQVSCQAHV 679

Query: 428  VAVIEPIIQHADWFFPE--EVEFNVSEAFVP----LTTPSSNHSFHTGNDSDSGTLERKR 481
              +I+ II H +  FP+  E++  V E  +       +P S H      D D+GT     
Sbjct: 680  NEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTS 739

Query: 482  PASMAVMEGDLVKKESPPKPKDPVSAAVPA-------------PGRNN------------ 516
                  +E  + K +   +    +S    A              GR+N            
Sbjct: 740  EDECEPIEA-IAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIV 798

Query: 517  --------SQIASGQNQPQAAAG------SHQLSMGQPHNAAGPSPHTLRRAVKKPAPAP 562
                    S   S +   +A++G      S    M  P +         +R   +P P  
Sbjct: 799  VQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPV 858

Query: 563  PKPGNPPPGH-----PGGQSSSGTSQHPPSLSPKP----PTRSPSPPTQHTGQPPGQPSA 613
             +PG    GH     P   S+S      PSL+  P      R  +  +    + PG  S 
Sbjct: 859  RRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRRRPGHGSL 918

Query: 614  PS--------QLSAP--RRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMAL 663
             +        ++ +P  RR +SS       +H P  P T A  +  T   +      +  
Sbjct: 919  TNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELER 978

Query: 664  PS--EHG-------LEQPSHTP-PQTPTPPSTP----PLGKQNPSLPAPQTLAGGNPETA 709
             S  +H        LEQ  ++P P T T   +P     L    P +    + +     T 
Sbjct: 979  QSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTF 1038

Query: 710  QPHAG---------TLPRPRPVPKPRNRPSVPPPPQPPG 739
            +P               RP+P   P+  P++ P P P G
Sbjct: 1039 KPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQG 1077


>gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]
          Length = 439

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 54/165 (32%), Positives = 93/165 (56%), Gaps = 3/165 (1%)

Query: 250 FGTPLEEHLKRSGREIALPI--EACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCST 307
           FG  L+   +++  +  +PI     V  L    +  EG+FR  A    +++++   +   
Sbjct: 242 FGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGL 301

Query: 308 SHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKL 367
               + Y++ H  A  LK++LRELPEPL+TF+LY       ++ D+ +++    +  Q L
Sbjct: 302 PVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTL 360

Query: 368 PPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARN 412
           P +N+   R+L  FL +++  SD NKMT +N+A+V GPNLLWA++
Sbjct: 361 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKD 405


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,877,766
Number of Sequences: 37866
Number of extensions: 2865875
Number of successful extensions: 57222
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 898
Number of HSP's successfully gapped in prelim test: 2677
Number of HSP's that attempted gapping in prelim test: 16273
Number of HSP's gapped (non-prelim): 18223
length of query: 803
length of database: 18,247,518
effective HSP length: 110
effective length of query: 693
effective length of database: 14,082,258
effective search space: 9759004794
effective search space used: 9759004794
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.