Search of human proteins with 54792084

Search of human proteins with 54792084

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54792084 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 3 [Homo sapiens]
         (300 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54792084 pleckstrin homology domain containing, family A (pho...   611   e-175
gi|14249174 pleckstrin homology domain containing, family A (pho...   259   3e-69
gi|4505531 oxysterol binding protein [Homo sapiens]                    96   3e-20
gi|22547173 oxysterol binding protein-like 9 isoform d [Homo sap...    92   6e-19
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap...    89   5e-18
gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens]       87   1e-17
gi|14165452 alpha 3 type IV collagen binding protein isoform 2 [...    86   4e-17
gi|194294543 alpha 3 type IV collagen binding protein isoform 3 ...    86   4e-17
gi|5031717 alpha 3 type IV collagen binding protein isoform 1 [H...    86   4e-17
gi|22547176 oxysterol binding protein-like 9 isoform f [Homo sap...    84   1e-16
gi|7705684 pleckstrin homology domain containing, family A (phos...    67   1e-11
gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]           56   4e-08
gi|19923812 oxysterol-binding protein-like protein 10 [Homo sapi...    52   5e-07
gi|217416392 pleckstrin homology domain containing, family H (wi...    49   7e-06
gi|29788755 SET binding factor 2 [Homo sapiens]                        47   2e-05
gi|93102364 SWAP-70 protein [Homo sapiens]                             44   2e-04
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    43   3e-04
gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo sa...    42   7e-04
gi|55741447 pleckstrin homology domain containing, family H (wit...    42   7e-04
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]    41   0.001
gi|22035612 oxysterol-binding protein-like protein 6 isoform b [...    40   0.003
gi|14210532 oxysterol-binding protein-like protein 6 isoform a [...    40   0.003
gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens]    40   0.003
gi|239735519 SET binding factor 1 [Homo sapiens]                       37   0.016
gi|156616273 pleckstrin [Homo sapiens]                                 37   0.021
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    37   0.021
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do...    36   0.036
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do...    36   0.036
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    36   0.036
gi|21735584 oxysterol-binding protein-like protein 3 isoform d [...    36   0.047

>gi|54792084 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 3 [Homo
           sapiens]
          Length = 300

 Score =  611 bits (1576), Expect = e-175
 Identities = 300/300 (100%), Positives = 300/300 (100%)

Query: 1   MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTR 60
           MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTR
Sbjct: 1   MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTR 60

Query: 61  MELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSEL 120
           MELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSEL
Sbjct: 61  MELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSEL 120

Query: 121 RLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAK 180
           RLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAK
Sbjct: 121 RLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAK 180

Query: 181 FKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRR 240
           FKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRR
Sbjct: 181 FKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRR 240

Query: 241 RTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS 300
           RTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS
Sbjct: 241 RTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS 300


>gi|14249174 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 8 [Homo
           sapiens]
          Length = 440

 Score =  259 bits (661), Expect = 3e-69
 Identities = 130/213 (61%), Positives = 158/213 (74%), Gaps = 10/213 (4%)

Query: 1   MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTR 60
           MEGVLYKWTNYL+GWQPRWF+L  GILSYYDS +D  KG KGSI+MAVCEI+VHS DNTR
Sbjct: 1   MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTR 60

Query: 61  MELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSEL 120
           M+LIIPGEQ+FY+KA + AERQRWLVALGS+KACLTD+RT+KEKE +E +E+LKTKMSEL
Sbjct: 61  MDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSEL 120

Query: 121 RLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAK 180
           RLYCDLL+QQV   +E      ++S    E   +  +LL +TCNTF+ TLEEC++IANA 
Sbjct: 121 RLYCDLLVQQVDKTKEVTTTGVSNS----EEGIDVGTLLKSTCNTFLKTLEECMQIANAA 176

Query: 181 FKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHP 213
           F  E+           P SP    +    + HP
Sbjct: 177 FTSELLY------RTPPGSPQLAMLKSSKMKHP 203


>gi|4505531 oxysterol binding protein [Homo sapiens]
          Length = 807

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 60/199 (30%), Positives = 98/199 (49%), Gaps = 20/199 (10%)

Query: 2   EGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRM 61
           EG L+KWTNY+ G+Q RWFVL NG+LSYY S+ ++    +G+I +A   I V   D+   
Sbjct: 92  EGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVE--DSCNF 149

Query: 62  ELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEK-------------EISE 108
            +   G Q +++KA +  ERQRW+ AL  +KA       + ++             E+  
Sbjct: 150 IISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQN 209

Query: 109 TSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAEN-----MNEASSLLSATC 163
           T  +L +K+ +L    DL+ +    +Q  +   E+   P+  N     +NE ++L   T 
Sbjct: 210 TLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITS 269

Query: 164 NTFITTLEECVKIANAKFK 182
           N  I    + + +A    K
Sbjct: 270 NAMINACRDFLMLAQTHSK 288


>gi|22547173 oxysterol binding protein-like 9 isoform d [Homo
           sapiens]
          Length = 723

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 82/309 (26%), Positives = 138/309 (44%), Gaps = 49/309 (15%)

Query: 1   MEGVLYKWTNYLTGWQPRWFVLD--NGILSYYDSQDDVCKGS-KGSIKMAVCEIKVHSAD 57
           MEG L KWTN + GWQ RWFVLD   G+LSYY S+D + +GS +G +++    I +   D
Sbjct: 5   MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64

Query: 58  NTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKM 117
           ++   + +  ++ F+ +A +A ER++W+ AL  +    T      +     + +    K+
Sbjct: 65  DSTFTITV-DQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKL 123

Query: 118 SELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECV--- 174
           +E   Y  +L++Q+         D+   +   +   +    L  T N+ + +++ C+   
Sbjct: 124 TEADAYLQILIEQLKLF------DDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLL 177

Query: 175 KIANAKFKPEMFQLHHPDPLVSPVS---------PSPVQMMKRSVSHPGSCSSERSSHSI 225
           +IA +   P +  ++ P PL   +S         P PVQ+          C SE+   S+
Sbjct: 178 QIAKSTINP-VDAIYQPSPLEPVISTMPSQTVLPPEPVQL----------CKSEQRPSSL 226

Query: 226 KEPVS-TLHRLSQRRRRTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLM 284
             PV   L  L   +  T + T S    P      P H        +L+  T+PE S   
Sbjct: 227 --PVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHV-------NLSPNTVPEFS--- 274

Query: 285 AKKQSESED 293
               S SED
Sbjct: 275 ---YSSSED 280


>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
           sapiens]
          Length = 736

 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 81/312 (25%), Positives = 140/312 (44%), Gaps = 42/312 (13%)

Query: 1   MEGVLYKWTNYLTGWQPRWFVLD--NGILSYYDSQDDVCKGS-KGSIKMAVCEIKVHSAD 57
           MEG L KWTN + GWQ RWFVLD   G+LSYY S+D + +GS +G +++    I +   D
Sbjct: 5   MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64

Query: 58  NTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKM 117
           ++   + +  ++ F+ +A +A ER++W+ AL  +    T      +     + +    K+
Sbjct: 65  DSTFTITV-DQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKL 123

Query: 118 SELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIA 177
           +E   Y  +L++Q+         D+   +   +   +    L  T N+ + +++ C+ + 
Sbjct: 124 TEADAYLQILIEQLKLF------DDKLQNCKEDEQRKKIETLKETTNSMVESIKHCIVLL 177

Query: 178 NAKFKPEMFQLHHPDPLVSPVS-------PSPVQ-----MMKRSVSHPGS---CSSERSS 222
               K +     H D ++S ++       PSP++     M  ++V  P     C SE+  
Sbjct: 178 QIA-KDQSNAEKHADGMISTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRP 236

Query: 223 HSIKEPVS-TLHRLSQRRRRTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEES 281
            S+  PV   L  L   +  T + T S    P      P H        +L+  T+PE S
Sbjct: 237 SSL--PVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHV-------NLSPNTVPEFS 287

Query: 282 RLMAKKQSESED 293
                  S SED
Sbjct: 288 ------YSSSED 293


>gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens]
          Length = 916

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 55/196 (28%), Positives = 93/196 (47%), Gaps = 23/196 (11%)

Query: 2   EGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRM 61
           EG L KWTNYL G+Q RWFVL NG+LSYY +Q ++    +G+I ++   I    +     
Sbjct: 186 EGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDSCGI-- 243

Query: 62  ELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLT---------------DTRTKKEKEI 106
            L+  G + +++KA +  +RQ+W+ AL  +KA                   T    + E+
Sbjct: 244 -LLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSEL 302

Query: 107 SETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAEN-----MNEASSLLSA 161
             T ++L  K+ +L    DL+ +    +Q  +   +    PS        +NE ++L   
Sbjct: 303 HHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRI 362

Query: 162 TCNTFITTLEECVKIA 177
           T N  I    + +++A
Sbjct: 363 TSNAMINACRDFLELA 378


>gi|14165452 alpha 3 type IV collagen binding protein isoform 2
           [Homo sapiens]
          Length = 598

 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 51/161 (31%), Positives = 81/161 (50%), Gaps = 33/161 (20%)

Query: 3   GVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRME 62
           GVL KWTNY+ GWQ RW VL N  LSYY S+D+   G +GSI ++   I  H  D  R +
Sbjct: 28  GVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFD 87

Query: 63  LIIPGEQHFYMKAVNAAERQRWLVAL--------------------------GSSKACLT 96
           + +  +  +Y++A +   RQ+W+ A+                          G+S    T
Sbjct: 88  ISV-NDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSAT 146

Query: 97  DTRTKKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEF 137
            T + K+        SL+ K++E+  + D+L +QV T+Q++
Sbjct: 147 STSSFKK------GHSLREKLAEMETFRDILCRQVDTLQKY 181


>gi|194294543 alpha 3 type IV collagen binding protein isoform 3
           [Homo sapiens]
          Length = 752

 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 51/161 (31%), Positives = 81/161 (50%), Gaps = 33/161 (20%)

Query: 3   GVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRME 62
           GVL KWTNY+ GWQ RW VL N  LSYY S+D+   G +GSI ++   I  H  D  R +
Sbjct: 156 GVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFD 215

Query: 63  LIIPGEQHFYMKAVNAAERQRWLVAL--------------------------GSSKACLT 96
           + +  +  +Y++A +   RQ+W+ A+                          G+S    T
Sbjct: 216 ISV-NDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSAT 274

Query: 97  DTRTKKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEF 137
            T + K+        SL+ K++E+  + D+L +QV T+Q++
Sbjct: 275 STSSFKK------GHSLREKLAEMETFRDILCRQVDTLQKY 309


>gi|5031717 alpha 3 type IV collagen binding protein isoform 1 [Homo
           sapiens]
          Length = 624

 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 51/161 (31%), Positives = 81/161 (50%), Gaps = 33/161 (20%)

Query: 3   GVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRME 62
           GVL KWTNY+ GWQ RW VL N  LSYY S+D+   G +GSI ++   I  H  D  R +
Sbjct: 28  GVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFD 87

Query: 63  LIIPGEQHFYMKAVNAAERQRWLVAL--------------------------GSSKACLT 96
           + +  +  +Y++A +   RQ+W+ A+                          G+S    T
Sbjct: 88  ISV-NDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSAT 146

Query: 97  DTRTKKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEF 137
            T + K+        SL+ K++E+  + D+L +QV T+Q++
Sbjct: 147 STSSFKK------GHSLREKLAEMETFRDILCRQVDTLQKY 181


>gi|22547176 oxysterol binding protein-like 9 isoform f [Homo
           sapiens]
          Length = 746

 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 84/332 (25%), Positives = 142/332 (42%), Gaps = 72/332 (21%)

Query: 1   MEGVLYKWTNYLTGWQPRWFVLD--NGILSYYDSQDDVCKGS-KGSIKMAVCEIKVHSAD 57
           MEG L KWTN + GWQ RWFVLD   G+LSYY S+D + +GS +G +++    I +   D
Sbjct: 5   MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64

Query: 58  NTRMELIIPGEQHFYMKAVNAAERQRWLVAL-------------GSSKACLTDTRTKKEK 104
           ++   + +  ++ F+ +A +A ER++W+ AL              ++ A    +      
Sbjct: 65  DSTFTITV-DQKTFHFQARDADEREKWIHALEETILRHTLQLQISTTLAFFQSSGISPVL 123

Query: 105 EISE----------TSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNE 154
           E S+          + +    K++E   Y  +L++Q+         D+   +   +   +
Sbjct: 124 EFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQLKLF------DDKLQNCKEDEQRK 177

Query: 155 ASSLLSATCNTFITTLEECV---KIANAKFKPEMFQLHHPDPLVSPVS---------PSP 202
               L  T N+ + +++ C+   +IA +   P +  ++ P PL   +S         P P
Sbjct: 178 KIETLKETTNSMVESIKHCIVLLQIAKSTINP-VDAIYQPSPLEPVISTMPSQTVLPPEP 236

Query: 203 VQMMKRSVSHPGSCSSERSSHSIKEPVS-TLHRLSQRRRRTYSDTDSCSDIPLEDPDRPV 261
           VQ+          C SE+   S+  PV   L  L   +  T + T S    P      P 
Sbjct: 237 VQL----------CKSEQRPSSL--PVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPS 284

Query: 262 HCSKNTLNGDLASATIPEESRLMAKKQSESED 293
           H        +L+  T+PE S       S SED
Sbjct: 285 HV-------NLSPNTVPEFS------YSSSED 303


>gi|7705684 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 9 [Homo
           sapiens]
          Length = 391

 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 41/97 (42%), Positives = 55/97 (56%), Gaps = 10/97 (10%)

Query: 117 MSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKI 176
           MSELRL CDLL+QQV   +E      ++S    E   +  +LL +TCNTF+ TLEEC++I
Sbjct: 1   MSELRLCCDLLVQQVDKTKEVTTTGVSNS----EEGIDVGTLLKSTCNTFLKTLEECMQI 56

Query: 177 ANAKFKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHP 213
           ANA F  E+  L+H      P SP    +    + HP
Sbjct: 57  ANAAFTSEL--LYH----TPPGSPQLAMLKSSKMKHP 87


>gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]
          Length = 747

 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 33/113 (29%), Positives = 57/113 (50%), Gaps = 2/113 (1%)

Query: 3   GVLYKWTNYLTGWQPRWFVLDN--GILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTR 60
           G L K+TN +TGWQ R+FVL+N  G+L Y+ ++    +  +G++++A   I     D+  
Sbjct: 63  GYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHT 122

Query: 61  MELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESL 113
             +     + + ++A +A ERQ W+  L       T+   K    +   S SL
Sbjct: 123 FTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSL 175


>gi|19923812 oxysterol-binding protein-like protein 10 [Homo
           sapiens]
          Length = 764

 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 30/96 (31%), Positives = 52/96 (54%), Gaps = 5/96 (5%)

Query: 1   MEGVLYKWTNYLTGWQPRWFVLD--NGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADN 58
           +EGVL K+TN L GWQ R+FVLD   GIL Y+ ++    +  +G + ++   + +     
Sbjct: 77  LEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAP 136

Query: 59  TRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKAC 94
             + +     + F ++A +A E+Q W+  L   +AC
Sbjct: 137 HMLVVYSANGEMFKLRAADAKEKQFWVTQL---RAC 169


>gi|217416392 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 2 [Homo sapiens]
          Length = 1493

 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 32/128 (25%), Positives = 56/128 (43%), Gaps = 4/128 (3%)

Query: 3   GVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRME 62
           G L K +  +  W+ RWFVL  G L YY S  DV +  +G I+++     +   DN +  
Sbjct: 708 GYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELS-ASCSILRGDNKQTV 766

Query: 63  LIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMS---E 119
            +   +  +Y+ A +    + W+  L +            + E   T + L TK+     
Sbjct: 767 QLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYS 826

Query: 120 LRLYCDLL 127
            R++C L+
Sbjct: 827 KRVWCTLI 834


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 34/108 (31%), Positives = 53/108 (49%), Gaps = 18/108 (16%)

Query: 2    EGVLYKWTNYLTGWQPRWFVLD--NGILSYYDSQDDVCKGSKGSIKMAVCEIKV------ 53
            EG LYK    L GW+PRWFVLD     L YYDS +D     KG I +A  E+ +      
Sbjct: 1747 EGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDT--SCKGHIDLAEVEMVIPAGPSM 1804

Query: 54   ----HSADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTD 97
                H++D    +L    ++ +   A +    Q+W+  +   ++C++D
Sbjct: 1805 GAPKHTSDKAFFDL-KTSKRVYNFCAQDGQSAQQWMDKI---QSCISD 1848


>gi|93102364 SWAP-70 protein [Homo sapiens]
          Length = 585

 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 39/179 (21%), Positives = 80/179 (44%), Gaps = 18/179 (10%)

Query: 2   EGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKM--AVCEIKVHSADNT 59
           +G + K  +    W  RWFVL   I+SYY S+D   K  KG I +    C   +   D  
Sbjct: 214 QGYMMKKGHRRKNWTERWFVLKPNIISYYVSED--LKDKKGDILLDENCCVESLPDKDGK 271

Query: 60  R-MELIIPGEQHFYMKAVNAAERQRWLVALGSS------------KACLTDTRTKKEKEI 106
           + + L+   ++ F + A +  ++Q W+ A+ S+            K      +  ++K++
Sbjct: 272 KCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQL 331

Query: 107 SETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNT 165
           +E  E L+ +M EL+   +   Q++  +++ +    + ++   +   +    L A  +T
Sbjct: 332 AE-QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFST 389


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 32/138 (23%), Positives = 61/138 (44%), Gaps = 5/138 (3%)

Query: 2   EGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKM-AVCEIKV-HSADNT 59
           +G L+K  +    W  RWF L    L Y+ S++  CK  +G I + A C ++V    D  
Sbjct: 220 QGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEE--CKEKRGIIPLDAHCCVEVLPDRDGK 277

Query: 60  R-MELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMS 118
           R M  +    + + M A +  +RQ W  A+  +     + +T   K++ +     + +  
Sbjct: 278 RCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRE 337

Query: 119 ELRLYCDLLMQQVHTIQE 136
             R   +  + ++  +QE
Sbjct: 338 RRRAAKEEELLRLQQLQE 355


>gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
           sapiens]
          Length = 950

 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 37/131 (28%), Positives = 62/131 (47%), Gaps = 17/131 (12%)

Query: 2   EGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVC-----KGSKGSIKMAVCEIKVHSA 56
           EG L+K + +  GW+  W VL++G+LS+Y  Q D       +G K  +  AVC +K  S 
Sbjct: 239 EGPLWKSSRFF-GWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCK-HLTQAVCTVK--ST 294

Query: 57  DNTRMEL-IIPGEQHFYMKAVNAAERQR--WLVALGSSKA-----CLTDTRTKKEKEISE 108
           D+    +       H +    N+ ++ R  WL A+    A     C  D  T +E+E + 
Sbjct: 295 DSCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTV 354

Query: 109 TSESLKTKMSE 119
           ++  LK  + +
Sbjct: 355 SAADLKKSLEK 365


>gi|55741447 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 1 [Homo sapiens]
          Length = 1364

 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 3/89 (3%)

Query: 3   GVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKM-AVCEIKVHSADNTRM 61
           G L K  + +  W+ RWFVL  G + YY S  DV +  +G + + + C+I     + ++ 
Sbjct: 583 GYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIV--RGEGSQT 640

Query: 62  ELIIPGEQHFYMKAVNAAERQRWLVALGS 90
             +I  ++ +Y+ A + +  + W+  L S
Sbjct: 641 FQLISEKKTYYLTADSPSLLEEWIRVLQS 669


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score = 41.2 bits (95), Expect = 0.001
 Identities = 23/88 (26%), Positives = 43/88 (48%), Gaps = 1/88 (1%)

Query: 1    MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCK-GSKGSIKMAVCEIKVHSADNT 59
            M G LY+       W+  WFV+ N +L  Y + +DV    S+  +   V ++K  ++++ 
Sbjct: 1336 MSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTVIQVKDENSESK 1395

Query: 60   RMELIIPGEQHFYMKAVNAAERQRWLVA 87
              +L+      +  KA +A   Q+W+ A
Sbjct: 1396 VFQLLHKNMLFYVFKAEDAHSAQKWIEA 1423


>gi|22035612 oxysterol-binding protein-like protein 6 isoform b
           [Homo sapiens]
          Length = 938

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 6/75 (8%)

Query: 7   KWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGS-KGSIKMAVCEIKVHSADNTRMELII 65
           KW   L GW  R+FVLDNG+L Y  +  D+ KG   GSI +    + V S       + +
Sbjct: 77  KWP--LKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVG---LSVMSIKKKARRIDL 131

Query: 66  PGEQHFYMKAVNAAE 80
             E+H Y   V + +
Sbjct: 132 DTEEHIYHLKVKSQD 146


>gi|14210532 oxysterol-binding protein-like protein 6 isoform a
           [Homo sapiens]
          Length = 934

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 6/75 (8%)

Query: 7   KWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGS-KGSIKMAVCEIKVHSADNTRMELII 65
           KW   L GW  R+FVLDNG+L Y  +  D+ KG   GSI +    + V S       + +
Sbjct: 98  KWP--LKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVG---LSVMSIKKKARRIDL 152

Query: 66  PGEQHFYMKAVNAAE 80
             E+H Y   V + +
Sbjct: 153 DTEEHIYHLKVKSQD 167


>gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens]
          Length = 842

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 7/84 (8%)

Query: 7   KWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGS-KGSIKMAVCEIKVHSADNTRMELII 65
           KW   L GW  R+FVL++GIL Y  ++ D+ KG   GSI +    + V S +     + +
Sbjct: 59  KWP--LKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDV---RLSVMSINKKAQRIDL 113

Query: 66  PGEQHFYMKAVNAAER-QRWLVAL 88
             E + Y   + + +  Q W+  L
Sbjct: 114 DTEDNIYHLKIKSQDLFQSWVAQL 137


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score = 37.4 bits (85), Expect = 0.016
 Identities = 20/41 (48%), Positives = 24/41 (58%), Gaps = 3/41 (7%)

Query: 2    EGVLYKWTNYLTGWQPRWFVLD--NGILSYYDSQ-DDVCKG 39
            EG LYK   ++  W+ RWFVLD     L YYD + D  CKG
Sbjct: 1791 EGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKG 1831


>gi|156616273 pleckstrin [Homo sapiens]
          Length = 350

 Score = 37.0 bits (84), Expect = 0.021
 Identities = 28/97 (28%), Positives = 43/97 (44%), Gaps = 12/97 (12%)

Query: 2   EGVLYKWTNYLTGWQPRWFVL--DNGILSYYDSQDDVCKGSKGSIKMAVCEI-KVHSADN 58
           +G L K  +    W+ R F+L  D   L YYD      +   G+I +  C +  V S  N
Sbjct: 248 QGCLLKQGHRRKNWKVRKFILREDPAYLHYYDPAG--AEDPLGAIHLRGCVVTSVESNSN 305

Query: 59  TR-------MELIIPGEQHFYMKAVNAAERQRWLVAL 88
            R        E+I   E H++++A    ER  W+ A+
Sbjct: 306 GRKSEEENLFEIITADEVHYFLQAATPKERTEWIRAI 342



 Score = 31.6 bits (70), Expect = 0.89
 Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 12/101 (11%)

Query: 2   EGVLYKWTNYLTGWQPRWFV-LDNGILSYYDSQDDVCKGS---KGSIKMAVCEIKVHSAD 57
           EG L K  +    W+P W V L++GI  Y    D+  KG    KGS   + C+       
Sbjct: 8   EGYLVKKGSVFNTWKPMWVVLLEDGIEFYKKKSDNSPKGMIPLKGSTLTSPCQ-----DF 62

Query: 58  NTRM---ELIIPGEQHFYMKAVNAAERQRWLVALGSSKACL 95
             RM   ++    +Q  + +A    ER  W+  +  +  C+
Sbjct: 63  GKRMFVFKITTTKQQDHFFQAAFLEERDAWVRDIKKAIKCI 103


>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
           2 [Homo sapiens]
          Length = 1704

 Score = 37.0 bits (84), Expect = 0.021
 Identities = 21/78 (26%), Positives = 37/78 (47%), Gaps = 8/78 (10%)

Query: 18  RWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSAD---NTR----MELIIPGEQH 70
           +W VL+ G LSYY++          +I   +C + +H  D   NT      E+ +P E+ 
Sbjct: 922 KWCVLEGGFLSYYENDKSTTPNGTININEVIC-LAIHKEDFYLNTGPIFIFEIYLPSERV 980

Query: 71  FYMKAVNAAERQRWLVAL 88
           F   A  +  +++W  A+
Sbjct: 981 FLFGAETSQAQRKWTEAI 998



 Score = 28.5 bits (62), Expect = 7.6
 Identities = 19/74 (25%), Positives = 35/74 (47%), Gaps = 4/74 (5%)

Query: 15  WQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRMELIIPGEQHFYMK 74
           +Q RW   D   +SYY+++ ++   SKG I ++         DN + E ++  ++ F  +
Sbjct: 500 FQKRWVKFDGLSISYYNNEKEMY--SKGIIPLSAISTVRVQGDN-KFE-VVTTQRTFVFR 555

Query: 75  AVNAAERQRWLVAL 88
                ER  W+  L
Sbjct: 556 VEKEEERNDWISIL 569


>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
           domain 1 isoform d [Homo sapiens]
          Length = 1133

 Score = 36.2 bits (82), Expect = 0.036
 Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 4/79 (5%)

Query: 15  WQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRMELIIPGEQHFYMK 74
           +Q RW  LD   L Y+DS  D    SK  I +A C   V +  + + E +I   + F  +
Sbjct: 100 YQKRWVRLDTDHLRYFDSNKDAY--SKRFISVA-CISHVAAIGDQKFE-VITNNRTFAFR 155

Query: 75  AVNAAERQRWLVALGSSKA 93
           A +  ER+ W+ AL  + A
Sbjct: 156 AESDVERKEWMQALQQAMA 174



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 18/78 (23%), Positives = 35/78 (44%), Gaps = 5/78 (6%)

Query: 18  RWFVLDNGILSYYDSQDDVCKGSKGSIKMAVC----EIKVHSADNTRMELIIPGEQHFYM 73
           RW VL +G+LSY++++  V    +      VC        H  ++T  E+   GE+ +  
Sbjct: 466 RWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHT-FEVYTEGERLYLF 524

Query: 74  KAVNAAERQRWLVALGSS 91
              +A +   W+  +  +
Sbjct: 525 GLESAEQAHEWVKCIAKA 542


>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
           domain 1 isoform a [Homo sapiens]
          Length = 1205

 Score = 36.2 bits (82), Expect = 0.036
 Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 4/79 (5%)

Query: 15  WQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRMELIIPGEQHFYMK 74
           +Q RW  LD   L Y+DS  D    SK  I +A C   V +  + + E +I   + F  +
Sbjct: 100 YQKRWVRLDTDHLRYFDSNKDAY--SKRFISVA-CISHVAAIGDQKFE-VITNNRTFAFR 155

Query: 75  AVNAAERQRWLVALGSSKA 93
           A +  ER+ W+ AL  + A
Sbjct: 156 AESDVERKEWMQALQQAMA 174



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 18/78 (23%), Positives = 35/78 (44%), Gaps = 5/78 (6%)

Query: 18  RWFVLDNGILSYYDSQDDVCKGSKGSIKMAVC----EIKVHSADNTRMELIIPGEQHFYM 73
           RW VL +G+LSY++++  V    +      VC        H  ++T  E+   GE+ +  
Sbjct: 527 RWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHT-FEVYTEGERLYLF 585

Query: 74  KAVNAAERQRWLVALGSS 91
              +A +   W+  +  +
Sbjct: 586 GLESAEQAHEWVKCIAKA 603


>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
           1 isoform c [Homo sapiens]
          Length = 1450

 Score = 36.2 bits (82), Expect = 0.036
 Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 4/79 (5%)

Query: 15  WQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRMELIIPGEQHFYMK 74
           +Q RW  LD   L Y+DS  D    SK  I +A C   V +  + + E +I   + F  +
Sbjct: 345 YQKRWVRLDTDHLRYFDSNKDAY--SKRFISVA-CISHVAAIGDQKFE-VITNNRTFAFR 400

Query: 75  AVNAAERQRWLVALGSSKA 93
           A +  ER+ W+ AL  + A
Sbjct: 401 AESDVERKEWMQALQQAMA 419



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 18/78 (23%), Positives = 35/78 (44%), Gaps = 5/78 (6%)

Query: 18  RWFVLDNGILSYYDSQDDVCKGSKGSIKMAVC----EIKVHSADNTRMELIIPGEQHFYM 73
           RW VL +G+LSY++++  V    +      VC        H  ++T  E+   GE+ +  
Sbjct: 772 RWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHT-FEVYTEGERLYLF 830

Query: 74  KAVNAAERQRWLVALGSS 91
              +A +   W+  +  +
Sbjct: 831 GLESAEQAHEWVKCIAKA 848


>gi|21735584 oxysterol-binding protein-like protein 3 isoform d
           [Homo sapiens]
          Length = 820

 Score = 35.8 bits (81), Expect = 0.047
 Identities = 25/75 (33%), Positives = 35/75 (46%), Gaps = 6/75 (8%)

Query: 7   KWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGS-KGSIKMAVCEIKVHSADNTRMELII 65
           KW   L GW  R+F LD GIL Y  SQ D+ +    G I +    + V S   +   + +
Sbjct: 63  KWP--LKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVG---LSVMSVKKSSKCIDL 117

Query: 66  PGEQHFYMKAVNAAE 80
             E+H Y   V + E
Sbjct: 118 DTEEHIYHLKVKSEE 132


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.126    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,961,125
Number of Sequences: 37866
Number of extensions: 542017
Number of successful extensions: 1985
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 87
Number of HSP's that attempted gapping in prelim test: 1883
Number of HSP's gapped (non-prelim): 175
length of query: 300
length of database: 18,247,518
effective HSP length: 102
effective length of query: 198
effective length of database: 14,385,186
effective search space: 2848266828
effective search space used: 2848266828
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.