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Search of human proteins with 54607141
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54607141 vacuolar protein sorting 13D isoform 2 [Homo
sapiens]
(4363 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54607141 vacuolar protein sorting 13D isoform 2 [Homo sapiens] 8699 0.0
gi|54607139 vacuolar protein sorting 13D isoform 1 [Homo sapiens] 8683 0.0
gi|42544121 vacuolar protein sorting 13C protein isoform 1A [Hom... 234 2e-60
gi|66348091 vacuolar protein sorting 13C protein isoform 1B [Hom... 234 2e-60
gi|66347845 vacuolar protein sorting 13C protein isoform 2B [Hom... 218 1e-55
gi|66347828 vacuolar protein sorting 13C protein isoform 2A [Hom... 218 1e-55
gi|15619008 vacuolar protein sorting 13A isoform B [Homo sapiens] 212 6e-54
gi|66346676 vacuolar protein sorting 13A isoform D [Homo sapiens] 212 6e-54
gi|66346674 vacuolar protein sorting 13A isoform A [Homo sapiens] 212 6e-54
gi|66346672 vacuolar protein sorting 13A isoform C [Homo sapiens] 212 6e-54
gi|35493713 vacuolar protein sorting 13B isoform 5 [Homo sapiens] 73 7e-12
gi|35493701 vacuolar protein sorting 13B isoform 1 [Homo sapiens] 73 7e-12
gi|119874215 vacuolar protein sorting 13B isoform 4 [Homo sapiens] 65 2e-09
gi|35493725 vacuolar protein sorting 13B isoform 3 [Homo sapiens] 65 2e-09
gi|239047271 autophagy related 2A [Homo sapiens] 50 4e-05
gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens] 49 1e-04
gi|55749659 UHRF1 (ICBP90) binding protein 1-like isoform b [Hom... 43 0.006
gi|55749644 UHRF1 (ICBP90) binding protein 1-like isoform a [Hom... 43 0.006
gi|239754902 PREDICTED: hypothetical protein [Homo sapiens] 40 0.039
gi|98986457 host cell factor 1 [Homo sapiens] 39 0.15
gi|148727247 ubiquitin specific peptidase 5 isoform 2 [Homo sapi... 38 0.25
gi|148727331 ubiquitin specific peptidase 5 isoform 1 [Homo sapi... 38 0.25
gi|171846268 Ts translation elongation factor, mitochondrial pre... 38 0.25
gi|28416946 myosin 18A isoform a [Homo sapiens] 36 0.96
gi|134152667 ICBP90 binding protein 1 [Homo sapiens] 35 1.2
gi|42794779 myosin 18A isoform b [Homo sapiens] 35 1.6
gi|27734911 DAZ interacting protein 1-like [Homo sapiens] 34 2.8
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 34 3.6
gi|75677385 neugrin [Homo sapiens] 33 4.7
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 33 4.7
>gi|54607141 vacuolar protein sorting 13D isoform 2 [Homo sapiens]
Length = 4363
Score = 8699 bits (22572), Expect = 0.0
Identities = 4363/4363 (100%), Positives = 4363/4363 (100%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF
Sbjct: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK
Sbjct: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
Query: 121 WKNDRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVS 180
WKNDRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVS
Sbjct: 121 WKNDRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVS 180
Query: 181 MQNAVNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLE 240
MQNAVNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLE
Sbjct: 181 MQNAVNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLE 240
Query: 241 PVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQV 300
PVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQV
Sbjct: 241 PVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQV 300
Query: 301 KFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL 360
KFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL
Sbjct: 301 KFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL 360
Query: 361 KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA 420
KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA
Sbjct: 361 KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA 420
Query: 421 PEPGGGSGMLQYLQSWFPGWGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDPT 480
PEPGGGSGMLQYLQSWFPGWGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDPT
Sbjct: 421 PEPGGGSGMLQYLQSWFPGWGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDPT 480
Query: 481 ADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESL 540
ADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESL
Sbjct: 481 ADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESL 540
Query: 541 PRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYP 600
PRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYP
Sbjct: 541 PRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYP 600
Query: 601 AADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFYKGKVHTSGFG 660
AADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFYKGKVHTSGFG
Sbjct: 601 AADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFYKGKVHTSGFG 660
Query: 661 YQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTVRLDISAPQVIF 720
YQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTVRLDISAPQVIF
Sbjct: 661 YQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTVRLDISAPQVIF 720
Query: 721 PDDFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEYKTPLATPPNTPP 780
PDDFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEYKTPLATPPNTPP
Sbjct: 721 PDDFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEYKTPLATPPNTPP 780
Query: 781 PESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQD 840
PESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQD
Sbjct: 781 PESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQD 840
Query: 841 IDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFAL 900
IDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFAL
Sbjct: 841 IDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFAL 900
Query: 901 LTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEFK 960
LTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEFK
Sbjct: 901 LTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEFK 960
Query: 961 VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFDLLM 1020
VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFDLLM
Sbjct: 961 VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFDLLM 1020
Query: 1021 ASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLI 1080
ASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLI
Sbjct: 1021 ASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLI 1080
Query: 1081 KLEYQFVSSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQ 1140
KLEYQFVSSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQ
Sbjct: 1081 KLEYQFVSSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQ 1140
Query: 1141 PLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGG 1200
PLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGG
Sbjct: 1141 PLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGG 1200
Query: 1201 TKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVR 1260
TKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVR
Sbjct: 1201 TKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVR 1260
Query: 1261 MEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKS 1320
MEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKS
Sbjct: 1261 MEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKS 1320
Query: 1321 AATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNIN 1380
AATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNIN
Sbjct: 1321 AATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNIN 1380
Query: 1381 IESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLA 1440
IESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLA
Sbjct: 1381 IESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLA 1440
Query: 1441 GREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKI 1500
GREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKI
Sbjct: 1441 GREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKI 1500
Query: 1501 PIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNK 1560
PIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNK
Sbjct: 1501 PIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNK 1560
Query: 1561 YPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLSNTSQKSLSVKEVKSFTQIQA 1620
YPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLSNTSQKSLSVKEVKSFTQIQA
Sbjct: 1561 YPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLSNTSQKSLSVKEVKSFTQIQA 1620
Query: 1621 TFCISELQVQLSGDLTLGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLEKN 1680
TFCISELQVQLSGDLTLGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLEKN
Sbjct: 1621 TFCISELQVQLSGDLTLGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLEKN 1680
Query: 1681 PDSKYKNLMVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQ 1740
PDSKYKNLMVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQ
Sbjct: 1681 PDSKYKNLMVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQ 1740
Query: 1741 RPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFS 1800
RPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFS
Sbjct: 1741 RPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFS 1800
Query: 1801 SSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEGILHNVKLEPH 1860
SSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEGILHNVKLEPH
Sbjct: 1801 SSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEGILHNVKLEPH 1860
Query: 1861 ASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGS 1920
ASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGS
Sbjct: 1861 ASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGS 1920
Query: 1921 LSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPLLRREHDIRVSLRMASVQYVHTQ 1980
LSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPLLRREHDIRVSLRMASVQYVHTQ
Sbjct: 1921 LSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPLLRREHDIRVSLRMASVQYVHTQ 1980
Query: 1981 RFQAEVVAFIQHFTQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSR 2040
RFQAEVVAFIQHFTQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSR
Sbjct: 1981 RFQAEVVAFIQHFTQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSR 2040
Query: 2041 SNNLIVANLGKLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGT 2100
SNNLIVANLGKLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGT
Sbjct: 2041 SNNLIVANLGKLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGT 2100
Query: 2101 HSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHVCLLDCVVVDL 2160
HSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHVCLLDCVVVDL
Sbjct: 2101 HSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHVCLLDCVVVDL 2160
Query: 2161 QDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSLLTEPCRLKLQVERNLDKEIS 2220
QDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSLLTEPCRLKLQVERNLDKEIS
Sbjct: 2161 QDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSLLTEPCRLKLQVERNLDKEIS 2220
Query: 2221 HTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIEEFMRPYDLQDPRIHTVLSGE 2280
HTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIEEFMRPYDLQDPRIHTVLSGE
Sbjct: 2221 HTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIEEFMRPYDLQDPRIHTVLSGE 2280
Query: 2281 VYTCMCFLIDMVNVSLELKDPKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMM 2340
VYTCMCFLIDMVNVSLELKDPKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMM
Sbjct: 2281 VYTCMCFLIDMVNVSLELKDPKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMM 2340
Query: 2341 AFDTRYAGQKTSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRV 2400
AFDTRYAGQKTSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRV
Sbjct: 2341 AFDTRYAGQKTSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRV 2400
Query: 2401 FLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVVTKRSSLPVSN 2460
FLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVVTKRSSLPVSN
Sbjct: 2401 FLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVVTKRSSLPVSN 2460
Query: 2461 ERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSC 2520
ERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSC
Sbjct: 2461 ERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSC 2520
Query: 2521 RLGNEHDTALSIVDPVQIQMELVGNSSYQNSSGLMDAFNSEDFPPVLEIQLQALDIRLSY 2580
RLGNEHDTALSIVDPVQIQMELVGNSSYQNSSGLMDAFNSEDFPPVLEIQLQALDIRLSY
Sbjct: 2521 RLGNEHDTALSIVDPVQIQMELVGNSSYQNSSGLMDAFNSEDFPPVLEIQLQALDIRLSY 2580
Query: 2581 NDVQLFLAIAKSIPEQANAAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLEL 2640
NDVQLFLAIAKSIPEQANAAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLEL
Sbjct: 2581 NDVQLFLAIAKSIPEQANAAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLEL 2640
Query: 2641 QLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPL 2700
QLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPL
Sbjct: 2641 QLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPL 2700
Query: 2701 ISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHFTLSGDYYNRA 2760
ISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHFTLSGDYYNRA
Sbjct: 2701 ISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHFTLSGDYYNRA 2760
Query: 2761 LSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRLDINITSVLIDQYVSTKESWM 2820
LSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRLDINITSVLIDQYVSTKESWM
Sbjct: 2761 LSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRLDINITSVLIDQYVSTKESWM 2820
Query: 2821 ADYCKDDKDIESAKSEDWMGSSVDPPCFGQTEVKTPKRRQPFVPFALRNHTGCTLWFATL 2880
ADYCKDDKDIESAKSEDWMGSSVDPPCFGQTEVKTPKRRQPFVPFALRNHTGCTLWFATL
Sbjct: 2821 ADYCKDDKDIESAKSEDWMGSSVDPPCFGQTEVKTPKRRQPFVPFALRNHTGCTLWFATL 2880
Query: 2881 TTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEWREVLTGEEIPFEFEARGKLRHRHTH 2940
TTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEWREVLTGEEIPFEFEARGKLRHRHTH
Sbjct: 2881 TTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEWREVLTGEEIPFEFEARGKLRHRHTH 2940
Query: 2941 DLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPDKNSSSSTIGSPSSRTNIIHPQVYFS 3000
DLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPDKNSSSSTIGSPSSRTNIIHPQVYFS
Sbjct: 2941 DLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPDKNSSSSTIGSPSSRTNIIHPQVYFS 3000
Query: 3001 SLPPVRVVFAVTMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGD 3060
SLPPVRVVFAVTMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGD
Sbjct: 3001 SLPPVRVVFAVTMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGD 3060
Query: 3061 SFAVPLHLTSWRLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRF 3120
SFAVPLHLTSWRLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRF
Sbjct: 3061 SFAVPLHLTSWRLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRF 3120
Query: 3121 CVAIKKENYPDYMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING 3180
CVAIKKENYPDYMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING
Sbjct: 3121 CVAIKKENYPDYMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING 3180
Query: 3181 TLKPGKEAALHTADTSQNIELGVSLENFPLCKELLIPPGTQNYMVRMRLYDVNRRQLNLT 3240
TLKPGKEAALHTADTSQNIELGVSLENFPLCKELLIPPGTQNYMVRMRLYDVNRRQLNLT
Sbjct: 3181 TLKPGKEAALHTADTSQNIELGVSLENFPLCKELLIPPGTQNYMVRMRLYDVNRRQLNLT 3240
Query: 3241 IRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCY 3300
IRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCY
Sbjct: 3241 IRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCY 3300
Query: 3301 ADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVK 3360
ADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVK
Sbjct: 3301 ADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVK 3360
Query: 3361 KGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHW 3420
KGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHW
Sbjct: 3361 KGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHW 3420
Query: 3421 PRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRI 3480
PRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRI
Sbjct: 3421 PRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRI 3480
Query: 3481 SFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT 3540
SFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT
Sbjct: 3481 SFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT 3540
Query: 3541 VKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYTFSGLQEGTGRPVASNKAITCAELVL 3600
VKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYTFSGLQEGTGRPVASNKAITCAELVL
Sbjct: 3541 VKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYTFSGLQEGTGRPVASNKAITCAELVL 3600
Query: 3601 DVSPKTQRVILKKKEPGKRSQLWRMTGTGMLAHEGSSVPHNPNKPSAARSTEGSAILDIA 3660
DVSPKTQRVILKKKEPGKRSQLWRMTGTGMLAHEGSSVPHNPNKPSAARSTEGSAILDIA
Sbjct: 3601 DVSPKTQRVILKKKEPGKRSQLWRMTGTGMLAHEGSSVPHNPNKPSAARSTEGSAILDIA 3660
Query: 3661 GLAAVTDNRYEPLMLRKPDRRRSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFDGAEVV 3720
GLAAVTDNRYEPLMLRKPDRRRSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFDGAEVV
Sbjct: 3661 GLAAVTDNRYEPLMLRKPDRRRSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFDGAEVV 3720
Query: 3721 LGPDTSMELLGPVPPEQQFINQKMRPGSGMLSIRVIPDGPTRALQITDFCHRKSSRSYEV 3780
LGPDTSMELLGPVPPEQQFINQKMRPGSGMLSIRVIPDGPTRALQITDFCHRKSSRSYEV
Sbjct: 3721 LGPDTSMELLGPVPPEQQFINQKMRPGSGMLSIRVIPDGPTRALQITDFCHRKSSRSYEV 3780
Query: 3781 DELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLSLINKVPEELVFASLTGINVHYTQLA 3840
DELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLSLINKVPEELVFASLTGINVHYTQLA
Sbjct: 3781 DELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLSLINKVPEELVFASLTGINVHYTQLA 3840
Query: 3841 TSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNENEVIETGPAVQVNAVKFPSKSALTN 3900
TSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNENEVIETGPAVQVNAVKFPSKSALTN
Sbjct: 3841 TSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNENEVIETGPAVQVNAVKFPSKSALTN 3900
Query: 3901 IYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAESEVEKYDENLHEKTAEQGGTPIRYYF 3960
IYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAESEVEKYDENLHEKTAEQGGTPIRYYF
Sbjct: 3901 IYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAESEVEKYDENLHEKTAEQGGTPIRYYF 3960
Query: 3961 ENLKISIPQIKLSVFTSNKLPLDLKALKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFI 4020
ENLKISIPQIKLSVFTSNKLPLDLKALKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFI
Sbjct: 3961 ENLKISIPQIKLSVFTSNKLPLDLKALKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFI 4020
Query: 4021 INDILKHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGVTGLIKYGNVGGLIRNVTHGV 4080
INDILKHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGVTGLIKYGNVGGLIRNVTHGV
Sbjct: 4021 INDILKHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGVTGLIKYGNVGGLIRNVTHGV 4080
Query: 4081 SNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVI 4140
SNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVI
Sbjct: 4081 SNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVI 4140
Query: 4141 TSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQ 4200
TSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQ
Sbjct: 4141 TSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQ 4200
Query: 4201 RVRKPRCCTGPQGLLPRYSESQAEGQEQLFKLTDNIQDEFFIAVENIDSYCVLISSKAVY 4260
RVRKPRCCTGPQGLLPRYSESQAEGQEQLFKLTDNIQDEFFIAVENIDSYCVLISSKAVY
Sbjct: 4201 RVRKPRCCTGPQGLLPRYSESQAEGQEQLFKLTDNIQDEFFIAVENIDSYCVLISSKAVY 4260
Query: 4261 FLKSGDYVDREAIFLEVKYDDLYHCLVSKDHGKVYVQVTKKAVSTSSGVSIPGPSHQKPM 4320
FLKSGDYVDREAIFLEVKYDDLYHCLVSKDHGKVYVQVTKKAVSTSSGVSIPGPSHQKPM
Sbjct: 4261 FLKSGDYVDREAIFLEVKYDDLYHCLVSKDHGKVYVQVTKKAVSTSSGVSIPGPSHQKPM 4320
Query: 4321 VHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLSENREQLELDS 4363
VHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLSENREQLELDS
Sbjct: 4321 VHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLSENREQLELDS 4363
>gi|54607139 vacuolar protein sorting 13D isoform 1 [Homo sapiens]
Length = 4388
Score = 8683 bits (22532), Expect = 0.0
Identities = 4362/4388 (99%), Positives = 4363/4388 (99%), Gaps = 25/4388 (0%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF
Sbjct: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK
Sbjct: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
Query: 121 WKNDRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVS 180
WKNDRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVS
Sbjct: 121 WKNDRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVS 180
Query: 181 MQNAVNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLE 240
MQNAVNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLE
Sbjct: 181 MQNAVNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLE 240
Query: 241 PVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQV 300
PVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQV
Sbjct: 241 PVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQV 300
Query: 301 KFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL 360
KFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL
Sbjct: 301 KFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL 360
Query: 361 KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA 420
KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA
Sbjct: 361 KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA 420
Query: 421 PEPGGGSGMLQYLQSWFPGWGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDPT 480
PEPGGGSGMLQYLQSWFPGWGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDPT
Sbjct: 421 PEPGGGSGMLQYLQSWFPGWGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDPT 480
Query: 481 ADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESL 540
ADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESL
Sbjct: 481 ADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESL 540
Query: 541 PRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYP 600
PRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYP
Sbjct: 541 PRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYP 600
Query: 601 AADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFYKGKVHTSGFG 660
AADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFYKGKVHTSGFG
Sbjct: 601 AADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFFYKGKVHTSGFG 660
Query: 661 YQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTVRLDISAPQVIF 720
YQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTVRLDISAPQVIF
Sbjct: 661 YQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTVRLDISAPQVIF 720
Query: 721 PDDFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEYKTPLATPPNTPP 780
PDDFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEYKTPLATPPNTPP
Sbjct: 721 PDDFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEYKTPLATPPNTPP 780
Query: 781 PESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQD 840
PESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQD
Sbjct: 781 PESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQD 840
Query: 841 IDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFAL 900
IDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFAL
Sbjct: 841 IDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFAL 900
Query: 901 LTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEFK 960
LTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEFK
Sbjct: 901 LTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEFK 960
Query: 961 VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFDLLM 1020
VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFDLLM
Sbjct: 961 VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFDLLM 1020
Query: 1021 ASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLI 1080
ASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLI
Sbjct: 1021 ASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLI 1080
Query: 1081 KLEYQFVSSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQ 1140
KLEYQFVSSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQ
Sbjct: 1081 KLEYQFVSSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQ 1140
Query: 1141 PLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGG 1200
PLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGG
Sbjct: 1141 PLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGG 1200
Query: 1201 TKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVR 1260
TKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVR
Sbjct: 1201 TKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVR 1260
Query: 1261 MEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKS 1320
MEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKS
Sbjct: 1261 MEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKS 1320
Query: 1321 AATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNIN 1380
AATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNIN
Sbjct: 1321 AATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNIN 1380
Query: 1381 IESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLA 1440
IESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLA
Sbjct: 1381 IESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLA 1440
Query: 1441 GREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKI 1500
GREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKI
Sbjct: 1441 GREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKI 1500
Query: 1501 PIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNK 1560
PIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNK
Sbjct: 1501 PIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNK 1560
Query: 1561 YPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLSNTSQKSLSVKEVKSFTQIQA 1620
YPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLSNTSQKSLSVKEVKSFTQIQA
Sbjct: 1561 YPASATSSPCPDSPLPPLSTCGESSVERKENGLFSHSSLSNTSQKSLSVKEVKSFTQIQA 1620
Query: 1621 TFCISELQVQLSGDLTLGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLEKN 1680
TFCISELQVQLSGDLTLGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLEKN
Sbjct: 1621 TFCISELQVQLSGDLTLGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLEKN 1680
Query: 1681 PDSKYKNLMVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQ 1740
PDSKYKNLMVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQ
Sbjct: 1681 PDSKYKNLMVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQ 1740
Query: 1741 RPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFS 1800
RPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFS
Sbjct: 1741 RPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFS 1800
Query: 1801 SSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEGILHNVKLEPH 1860
SSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEGILHNVKLEPH
Sbjct: 1801 SSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHAMRLPPEGILHNVKLEPH 1860
Query: 1861 ASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGS 1920
ASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGS
Sbjct: 1861 ASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGS 1920
Query: 1921 LSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPLLRREHDIRVSLRMASVQYVHTQ 1980
LSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPLLRREHDIRVSLRMASVQYVHTQ
Sbjct: 1921 LSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPLLRREHDIRVSLRMASVQYVHTQ 1980
Query: 1981 RFQAEVVAFIQHFTQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSR 2040
RFQAEVVAFIQHFTQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSR
Sbjct: 1981 RFQAEVVAFIQHFTQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSR 2040
Query: 2041 SNNLIVANLGKLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGT 2100
SNNLIVANLGKLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGT
Sbjct: 2041 SNNLIVANLGKLKVKNKFLFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGT 2100
Query: 2101 HSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHVCLLDCVVVDL 2160
HSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHVCLLDCVVVDL
Sbjct: 2101 HSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPEDHVCLLDCVVVDL 2160
Query: 2161 QDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSLLTEPCRLKLQVERNLDKEIS 2220
QDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSLLTEPCRLKLQVERNLDKEIS
Sbjct: 2161 QDMDIFAAERHPREYSKAPEDSSGDLIFPSYFVRQTGGSLLTEPCRLKLQVERNLDKEIS 2220
Query: 2221 HTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIEEFMRPYDLQDPRIHTVLSGE 2280
HTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIEEFMRPYDLQDPRIHTVLSGE
Sbjct: 2221 HTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIEEFMRPYDLQDPRIHTVLSGE 2280
Query: 2281 VYTCMCFLIDMVNVSLELKDPKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMM 2340
VYTCMCFLIDMVNVSLELKDPKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMM
Sbjct: 2281 VYTCMCFLIDMVNVSLELKDPKRKEGAGSLARFDFKKCKLLYESFSNQTKSINLVSHSMM 2340
Query: 2341 AFDTRYAGQKTSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRV 2400
AFDTRYAGQKTSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRV
Sbjct: 2341 AFDTRYAGQKTSPGMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRV 2400
Query: 2401 FLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVVTKRSSLPVSN 2460
FLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVVTKRSSLPVSN
Sbjct: 2401 FLIFDWLLLVHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKSGVVTKRSSLPVSN 2460
Query: 2461 ERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSC 2520
ERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSC
Sbjct: 2461 ERHLEVKVNVTGTEFVVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSC 2520
Query: 2521 RLGNEHDTALSIVDPVQIQMELVGNSSYQNSSGLMDAFNSEDFPPVLEIQLQALDIRLSY 2580
RLGNEHDTALSIVDPVQIQMELVGNSSYQNSSGLMDAFNSEDFPPVLEIQLQALDIRLSY
Sbjct: 2521 RLGNEHDTALSIVDPVQIQMELVGNSSYQNSSGLMDAFNSEDFPPVLEIQLQALDIRLSY 2580
Query: 2581 NDVQLFLAIAKSIPEQANAAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLEL 2640
NDVQLFLAIAKSIPEQANAAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLEL
Sbjct: 2581 NDVQLFLAIAKSIPEQANAAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLEL 2640
Query: 2641 QLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPL 2700
QLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPL
Sbjct: 2641 QLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAEPLKSLSLASTSRDSPGAVAAPL 2700
Query: 2701 ISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHFTLSGDYYNRA 2760
ISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHFTLSGDYYNRA
Sbjct: 2701 ISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLNFLQRVRTSPEGYAHFTLSGDYYNRA 2760
Query: 2761 LSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRLDINITSVLIDQYVSTKESWM 2820
LSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRLDINITSVLIDQYVSTKESWM
Sbjct: 2761 LSGWEPFIEPWPCSVSWQQQAASRLHPPRLKLEAKAKPRLDINITSVLIDQYVSTKESWM 2820
Query: 2821 ADYCKDDKDIESAKSEDWMGSSVDPPCFGQT-------------------------EVKT 2855
ADYCKDDKDIESAKSEDWMGSSVDPPCFGQ+ EVKT
Sbjct: 2821 ADYCKDDKDIESAKSEDWMGSSVDPPCFGQSLPLVYLRTRSTASLTNLEHQIYARAEVKT 2880
Query: 2856 PKRRQPFVPFALRNHTGCTLWFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEW 2915
PKRRQPFVPFALRNHTGCTLWFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEW
Sbjct: 2881 PKRRQPFVPFALRNHTGCTLWFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEW 2940
Query: 2916 REVLTGEEIPFEFEARGKLRHRHTHDLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPD 2975
REVLTGEEIPFEFEARGKLRHRHTHDLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPD
Sbjct: 2941 REVLTGEEIPFEFEARGKLRHRHTHDLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPD 3000
Query: 2976 KNSSSSTIGSPSSRTNIIHPQVYFSSLPPVRVVFAVTMEGSARKVITVRSALIVRNRLET 3035
KNSSSSTIGSPSSRTNIIHPQVYFSSLPPVRVVFAVTMEGSARKVITVRSALIVRNRLET
Sbjct: 3001 KNSSSSTIGSPSSRTNIIHPQVYFSSLPPVRVVFAVTMEGSARKVITVRSALIVRNRLET 3060
Query: 3036 PMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSWRLQARPKGLGVFFCKAPIHWTNVV 3095
PMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSWRLQARPKGLGVFFCKAPIHWTNVV
Sbjct: 3061 PMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSWRLQARPKGLGVFFCKAPIHWTNVV 3120
Query: 3096 KTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPDYMPSNIFSDSAKQIFRQPGHTIYL 3155
KTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPDYMPSNIFSDSAKQIFRQPGHTIYL
Sbjct: 3121 KTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPDYMPSNIFSDSAKQIFRQPGHTIYL 3180
Query: 3156 LPTVVICNLLPCELDFYVKGMPINGTLKPGKEAALHTADTSQNIELGVSLENFPLCKELL 3215
LPTVVICNLLPCELDFYVKGMPINGTLKPGKEAALHTADTSQNIELGVSLENFPLCKELL
Sbjct: 3181 LPTVVICNLLPCELDFYVKGMPINGTLKPGKEAALHTADTSQNIELGVSLENFPLCKELL 3240
Query: 3216 IPPGTQNYMVRMRLYDVNRRQLNLTIRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDN 3275
IPPGTQNYMVRMRLYDVNRRQLNLTIRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDN
Sbjct: 3241 IPPGTQNYMVRMRLYDVNRRQLNLTIRIVCRAEGSLKIFISAPYWLINKTGLPLIFRQDN 3300
Query: 3276 AKTDAAGQFEEHELARSLSPLLFCYADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGS 3335
AKTDAAGQFEEHELARSLSPLLFCYADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGS
Sbjct: 3301 AKTDAAGQFEEHELARSLSPLLFCYADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGS 3360
Query: 3336 GVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREF 3395
GVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREF
Sbjct: 3361 GVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREF 3420
Query: 3396 ARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHI 3455
ARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHI
Sbjct: 3421 ARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHI 3480
Query: 3456 NMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLR 3515
NMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLR
Sbjct: 3481 NMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLR 3540
Query: 3516 TEVKPMTSLDYAWDEPTLPPFITLTVKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYT 3575
TEVKPMTSLDYAWDEPTLPPFITLTVKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYT
Sbjct: 3541 TEVKPMTSLDYAWDEPTLPPFITLTVKGAGSSEINCNMNDFQDNRQLYYENFIYIAATYT 3600
Query: 3576 FSGLQEGTGRPVASNKAITCAELVLDVSPKTQRVILKKKEPGKRSQLWRMTGTGMLAHEG 3635
FSGLQEGTGRPVASNKAITCAELVLDVSPKTQRVILKKKEPGKRSQLWRMTGTGMLAHEG
Sbjct: 3601 FSGLQEGTGRPVASNKAITCAELVLDVSPKTQRVILKKKEPGKRSQLWRMTGTGMLAHEG 3660
Query: 3636 SSVPHNPNKPSAARSTEGSAILDIAGLAAVTDNRYEPLMLRKPDRRRSTTQTWSFREGKL 3695
SSVPHNPNKPSAARSTEGSAILDIAGLAAVTDNRYEPLMLRKPDRRRSTTQTWSFREGKL
Sbjct: 3661 SSVPHNPNKPSAARSTEGSAILDIAGLAAVTDNRYEPLMLRKPDRRRSTTQTWSFREGKL 3720
Query: 3696 TCGLHGLVVQAKGGLSGLFDGAEVVLGPDTSMELLGPVPPEQQFINQKMRPGSGMLSIRV 3755
TCGLHGLVVQAKGGLSGLFDGAEVVLGPDTSMELLGPVPPEQQFINQKMRPGSGMLSIRV
Sbjct: 3721 TCGLHGLVVQAKGGLSGLFDGAEVVLGPDTSMELLGPVPPEQQFINQKMRPGSGMLSIRV 3780
Query: 3756 IPDGPTRALQITDFCHRKSSRSYEVDELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLS 3815
IPDGPTRALQITDFCHRKSSRSYEVDELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLS
Sbjct: 3781 IPDGPTRALQITDFCHRKSSRSYEVDELPVTEQELQKLKNPDTEQELEVLVRLEGGIGLS 3840
Query: 3816 LINKVPEELVFASLTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNE 3875
LINKVPEELVFASLTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNE
Sbjct: 3841 LINKVPEELVFASLTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLYVTPLSNE 3900
Query: 3876 NEVIETGPAVQVNAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAES 3935
NEVIETGPAVQVNAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAES
Sbjct: 3901 NEVIETGPAVQVNAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAES 3960
Query: 3936 EVEKYDENLHEKTAEQGGTPIRYYFENLKISIPQIKLSVFTSNKLPLDLKALKSTLGFPL 3995
EVEKYDENLHEKTAEQGGTPIRYYFENLKISIPQIKLSVFTSNKLPLDLKALKSTLGFPL
Sbjct: 3961 EVEKYDENLHEKTAEQGGTPIRYYFENLKISIPQIKLSVFTSNKLPLDLKALKSTLGFPL 4020
Query: 3996 IRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFLGNPMGLLND 4055
IRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFLGNPMGLLND
Sbjct: 4021 IRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFLGNPMGLLND 4080
Query: 4056 VSEGVTGLIKYGNVGGLIRNVTHGVSNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAA 4115
VSEGVTGLIKYGNVGGLIRNVTHGVSNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAA
Sbjct: 4081 VSEGVTGLIKYGNVGGLIRNVTHGVSNSAAKFAGTLSDGLGKTMDNRHQSEREYIRYHAA 4140
Query: 4116 TSGEHLVAGIHGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGA 4175
TSGEHLVAGIHGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGA
Sbjct: 4141 TSGEHLVAGIHGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGA 4200
Query: 4176 LDFASETAQAVRDTATLSGPRTQAQRVRKPRCCTGPQGLLPRYSESQAEGQEQLFKLTDN 4235
LDFASETAQAVRDTATLSGPRTQAQRVRKPRCCTGPQGLLPRYSESQAEGQEQLFKLTDN
Sbjct: 4201 LDFASETAQAVRDTATLSGPRTQAQRVRKPRCCTGPQGLLPRYSESQAEGQEQLFKLTDN 4260
Query: 4236 IQDEFFIAVENIDSYCVLISSKAVYFLKSGDYVDREAIFLEVKYDDLYHCLVSKDHGKVY 4295
IQDEFFIAVENIDSYCVLISSKAVYFLKSGDYVDREAIFLEVKYDDLYHCLVSKDHGKVY
Sbjct: 4261 IQDEFFIAVENIDSYCVLISSKAVYFLKSGDYVDREAIFLEVKYDDLYHCLVSKDHGKVY 4320
Query: 4296 VQVTKKAVSTSSGVSIPGPSHQKPMVHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLSEN 4355
VQVTKKAVSTSSGVSIPGPSHQKPMVHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLSEN
Sbjct: 4321 VQVTKKAVSTSSGVSIPGPSHQKPMVHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLSEN 4380
Query: 4356 REQLELDS 4363
REQLELDS
Sbjct: 4381 REQLELDS 4388
>gi|42544121 vacuolar protein sorting 13C protein isoform 1A [Homo
sapiens]
Length = 3710
Score = 234 bits (596), Expect = 2e-60
Identities = 313/1479 (21%), Positives = 604/1479 (40%), Gaps = 268/1479 (18%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
+LE +VA +LN +LG YV NLN QL + + G V L+NL +K++AL EL++PF+VKAG
Sbjct: 2 VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQ 61
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
I K+TL+IP+ + + V ++ L+L+ P ++ KE+ ++ K+ L +EE
Sbjct: 62 IDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEA 121
Query: 121 WKN--DRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKN 178
+ ++ + E+ + + T++++N+++KI D+H+++ED VT+P P +FG+ +
Sbjct: 122 LQKAAEKDKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGE 181
Query: 179 VSMQNA--------VNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSM 230
+S+ A +NE + + + +LD S YW+V+C++ + ++ + + +
Sbjct: 182 LSLLTANEHWTPCILNEADKIIYKLIRLD--SLSAYWNVNCSMSYQRSREQILDQLKNEI 239
Query: 231 ESR-----SHHYVLEPVFASALLKRN-CSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYR 284
+ ++ Y+ +P+ ASA L N ++ L+ +P++DC+I+++ I ++L++ QY
Sbjct: 240 LTSGNIPPNYQYIFQPISASAKLYMNPYAESELK---TPKLDCNIEIQNIAIELTKPQYL 296
Query: 285 QIMEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFML 343
+++ L+ ++ R +R++KP + + N R WW +A+++ L IR + +W +
Sbjct: 297 SMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIK 356
Query: 344 HRARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELA 403
+ SY Y NKL +S + ++E+ +E+ + + R Q+
Sbjct: 357 KHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILAR---------QQAQV 407
Query: 404 ESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPG-WGGWYGQQTPEGNVVEGLSAEQQ 462
E +R Q + + GG WF G WG ++ + +
Sbjct: 408 EVIRSGQKLRKKSADTGEKRGG----------WFSGLWGKKESKK------------KDE 445
Query: 463 EQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNE 522
E IPE I + T ++D +F + +TL P+
Sbjct: 446 ESLIPETI-------------DDLMTPEEKDKLFTAIGYSESTHNLTL-------PKQYV 485
Query: 523 SAFMQLEFSDVKLLAESLPRRNS----SLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKE 578
+ M L KL++ S+ R + +L +++ GL GT V P +
Sbjct: 486 AHIMTL-----KLVSTSVTIRENKNIPEILKIQIIGL--------GTQ----VSQRPGAQ 528
Query: 579 VGRVSQSF------GLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRP 632
+V GL+ S D + ++ +E NP S ++ L V ++P
Sbjct: 529 ALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQP 588
Query: 633 LNIIYNPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTL 692
+ +IY+ + + V +FF K G E ++ A + ++K +T +
Sbjct: 589 VEVIYDAKTVNAVVEFFQSNK------GLDLE---QITSATLMKLEEIKERTATGLTH-- 637
Query: 693 DRLLVGDFIEESKRWTVRLDISAPQVIFPD-DFKFKNPVLVVVDLGRMLLTNTQDNSRRK 751
IE K +R+++ ++ P F + L+++D G L N++D +K
Sbjct: 638 -------IIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGTFQL-NSKDQGLQK 689
Query: 752 SRDGSASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMST 811
+ + S E +
Sbjct: 690 TTNSSLEE-------------------------------------------------IMD 700
Query: 812 KMYERYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYP 871
K Y+++ + ++Q++ R ++ WK + H+++ ++H++L + ++ D +
Sbjct: 701 KAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMA 759
Query: 872 GAVLSGNLPDLKIHINEDK---ISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQRGSLQ 928
+SG LP + + I++ K + L N L ++ + Q+ +G L
Sbjct: 760 RFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSSIPIISGGTKGLLG 819
Query: 929 DSVMNLTQSIVLLEQHTREVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTN---A 985
S++ T +++ E Q + + N I++L F
Sbjct: 820 TSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVIL 879
Query: 986 HFVKRPYDAEVSL--TVHGLLLVDTMQTYGADFDLLMASH-KNLSFDIPTGSLRDSRAQS 1042
F K+ + + L V L TM+T FDL + S+ K +S D
Sbjct: 880 EFTKQQKEEDTILVFNVTQLGTEATMRT----FDLTVVSYLKKISLDY------------ 923
Query: 1043 PVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTL 1100
H +G+ S S K L+K+EY PS T
Sbjct: 924 --------HEIEGSKRKPLHLISSS-----DKPGLDLLKVEYIKADKNGPSFQTAFGKTE 970
Query: 1101 QVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQPLMTDFERSFREQGTYQSTY 1160
Q + + ++L+++L + +V I +L P + +S + ++ T
Sbjct: 971 QTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAI 1030
Query: 1161 EQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGGTKVNVSMGS-TFDMNGSLGC 1219
+ + + RL L + EK IA I G ++S+ S + L
Sbjct: 1031 VSSRDSDIIDFRLFAKLNAFCVIVCNEK--NNIAEIKIQGLDSSLSLQSRKQSLFARLEN 1088
Query: 1220 LQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSK 1279
+ + D+ V + V +GN V N+ D+ DA TE +T + SK
Sbjct: 1089 IIVTDVDPKTVHKKAVSIMGNEVFRFNL--DL---------YPDA--TEGDLYT--DMSK 1133
Query: 1280 QECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEM 1339
+ L+L + + + KFL L NF ++A ++ A +
Sbjct: 1134 VDGVLSLNVGCIQIVYLHKFLMSLL--------NFLNNFQTAKESLSAATAQAAERAATS 1185
Query: 1340 VSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLV 1399
V DLA + ++ +NI++++PV+ IP+ S +V
Sbjct: 1186 VK----------------------DLAQR---SFRVSINIDLKAPVIVIPQSSISTNAVV 1220
Query: 1400 GHLGQIFIQN-FVAGDDESR-----SDRLQVEIKDIKLY 1432
LG I + N F DE DR+ V++ + LY
Sbjct: 1221 VDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLY 1259
Score = 144 bits (362), Expect = 2e-33
Identities = 139/574 (24%), Positives = 258/574 (44%), Gaps = 63/574 (10%)
Query: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887
L+GI + + Q + L + +QVDNQL G P + + V P + E P + V
Sbjct: 3141 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDV 3200
Query: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAESEVEK-----YDE 3942
+ + ++ + +K+ M+ Q ++I++ L +++ F + E E+ +
Sbjct: 3201 SVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFT-PTTDPEAERRRTKLIQQ 3259
Query: 3943 NLHEKTAEQGGTP-----IRYYFENLKISIPQIKLSVFT------SNKLPLDLKALKS-- 3989
++ AE T I +FE+ IS ++ LS+ S+K ++ A+ S
Sbjct: 3260 DIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHSVN 3319
Query: 3990 ----TLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDF 4045
++G L +D + L + + + ++ +I +++H+ E+ L Q ++ +D
Sbjct: 3320 LLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDV 3379
Query: 4046 LGNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFA 4088
LGNP GL+ +SEGV L G V G L + G + ++
Sbjct: 3380 LGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3439
Query: 4089 GTLSDGLGK-TMDNRHQSE-REYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEG 4146
G++ GL TMD +Q + RE + G+ L G G G++GG+T +IT VEG
Sbjct: 3440 GSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEG 3499
Query: 4147 VKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPR 4206
K E G +GF G+GKGLVG V +P G +D AS T Q ++ A + + +R PR
Sbjct: 3500 AKKE-GAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAEST---EEVSSLRPPR 3555
Query: 4207 CCTGPQGLLPRYSESQAEGQEQLFKLTDNIQDE---FFIAVENIDSYCVLISSKAVYFLK 4263
G++ Y ++EG + L ++ E + A+ ++++++ V +K
Sbjct: 3556 -LIHEDGIIRPYDRQESEGSDLLENHIKKLEGETYRYHCAIPGSKKTILMVTNRRVLCIK 3614
Query: 4264 SGDYVDREAIFLEVKYDD-LYHCLVSKDHGKVYVQ---VTKKAVSTSSGVSIPGPSHQKP 4319
+ + + + ++D ++ VS++ K+ V+ + K S + G
Sbjct: 3615 EVEILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDSANQGC--------VR 3666
Query: 4320 MVHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLS 4353
V++K A + I A+S +Q+LM + S
Sbjct: 3667 KVYLKDTATAERACNAIEDAQSTRQQQKLMKQSS 3700
Score = 84.3 bits (207), Expect = 2e-15
Identities = 65/289 (22%), Positives = 140/289 (48%), Gaps = 17/289 (5%)
Query: 1784 LVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHA 1843
L+ + DK P F +++ + +++ V F+ L++L+ Q V +++ +D+ +
Sbjct: 947 LLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQS 1006
Query: 1844 MRLPPEGILHNVKLE-----PHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANV 1898
+ + E + K + P A + S D ++ +L K+++ +++ + +A+ +
Sbjct: 1007 ISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKI 1066
Query: 1899 SKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPL 1958
L + L + +L + ++ ++D+ +++ + G E F Y PD
Sbjct: 1067 QGLDSSLSLQSRKQSLFARLENIIVTDVDPK-TVHKKAVSIMGNEVFRFNLDLY--PDAT 1123
Query: 1959 L------RREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIEG 2009
+ D +SL + +Q V+ +F ++ F+ +F ++ L Q A
Sbjct: 1124 EGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAA 1183
Query: 2010 QTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058
+V+D AQR RV ++I+ APV++IP+SS S N +V +LG ++V N+F
Sbjct: 1184 TSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQF 1232
Score = 82.8 bits (203), Expect = 7e-15
Identities = 66/305 (21%), Positives = 147/305 (48%), Gaps = 20/305 (6%)
Query: 1770 EPKILVGKSKF-DDSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVV 1828
EP ++ S D+ L+ + + D PEF + ++ + + V F LD+++ L+ +
Sbjct: 1447 EPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1506
Query: 1829 ILDF------FGIGSTADNHAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSL 1882
+DF F S+++ + P G ++ ++ +S S +D + K+ ++++
Sbjct: 1507 FMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQ-KDVFDLKITAELNAF 1565
Query: 1883 SLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGE 1942
++ + +A + + A + + + + + + ++ +++ + G+
Sbjct: 1566 NVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQS-IHKKAVSILGD 1624
Query: 1943 EALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQL 1996
E FQ Y PD + D ++S ++ +Q V+ +F ++ F+ +F
Sbjct: 1625 EVFRFQLTLY--PDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1682
Query: 1997 QDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLK 2053
++ L Q A +++D AQ+ R+L+DI APV++IP+SS S N ++A+LG ++
Sbjct: 1683 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1742
Query: 2054 VKNKF 2058
V+NKF
Sbjct: 1743 VENKF 1747
Score = 53.9 bits (128), Expect = 3e-06
Identities = 96/441 (21%), Positives = 173/441 (39%), Gaps = 70/441 (15%)
Query: 3151 HTIYLLPTVVICNLLPCELDFYVKGMPINGTLKPGKEA-ALHTADTSQNIELGVSLENFP 3209
+ I+L P++ + NLLP L + ++G L G A LH+ + + +EL
Sbjct: 2619 YIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTADVLHSRISGEIMEL-------- 2670
Query: 3210 LCKELLIPPGTQNYMVRMRLYDV------------NRRQLNLTIRIVCRAEGSLKIF-IS 3256
+L+ +N+ R+ D + + + + R GS + +
Sbjct: 2671 ----VLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRIGSRMVLSVF 2726
Query: 3257 APYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKE--QPNLCTMRIG 3314
+PYWLINKT L +R ++ F + +LF + K N ++I
Sbjct: 2727 SPYWLINKTTRVLQYRSEDIHVKHPADFRD--------IILFSFKKKNIFTKNKVQLKIS 2778
Query: 3315 RGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIF 3374
W FSLD +K + Y +G+ +K + + +V
Sbjct: 2779 TS-------AWSSSFSLDTVGSYGCVKCPAN----NMEYLVGVSIK--MSSFNLSRIVTL 2825
Query: 3375 APRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLM 3434
P + NKSS +L + + G N YI++ S + WP + LCVR
Sbjct: 2826 TPFCTIANKSSLELEVGEIA-SDGSMPTNKWNYIAS---SECLPFWPES-LSGKLCVR-- 2878
Query: 3435 DVPNCIWSGG--FEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPF 3492
V C S F ++N +++ D G + V++ + I+FSD + P
Sbjct: 2879 -VVGCEGSSKPFFYNRQDNGTLLSLEDLNGG---ILVDVNTAEHSTVITFSDYHEGSAPA 2934
Query: 3493 RIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT-VKGAGSSEI- 3549
I N + ++ + Q G E + + P + +AW +PT +T T G ++
Sbjct: 2935 LIMNHTPWDILTYKQSGSPEEMV---LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLL 2991
Query: 3550 --NCNMNDFQDNRQLYYENFI 3568
C + N Q+++ +F+
Sbjct: 2992 KDGCGQFPYDANIQIHWVSFL 3012
Score = 52.0 bits (123), Expect = 1e-05
Identities = 122/611 (19%), Positives = 236/611 (38%), Gaps = 138/611 (22%)
Query: 848 VVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFALLTTPEMK 907
++ N+ + R L + K P + G+L + + +N++ ++ L F +LT E
Sbjct: 1274 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLL---FRILT--ENL 1328
Query: 908 TSDTQIKEKIFPQEEQRG--------SLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEF 959
T+ +K+ P+ ++ G S+ V + ++ + R V + + LL E
Sbjct: 1329 CEGTEDLDKVKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEI 1388
Query: 960 K--VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFD 1017
K V + E GR + L V + YD +T L +MQ + DF
Sbjct: 1389 KEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYD----MTAKAYLKKISMQCF--DFT 1442
Query: 1018 LLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQE 1077
DS+ + P+ N +++TD E
Sbjct: 1443 -------------------DSKGE-PLHIINSSNVTD----------------------E 1460
Query: 1078 SLIKLEYQFVSSECPSMNL--DSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKD 1135
L+K+ S+ P DST Q + + +LD++L+ E ++ + FL + P +
Sbjct: 1461 PLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPFSEP 1520
Query: 1136 DLSPQ-----PLMTDFERSFREQGTYQSTYEQNT---EVAVEIHRLNLLLLRTVGMANRE 1187
S + PL+ + RS + + +++ ++ E++ N+ +
Sbjct: 1521 SSSEKESELKPLVGE-SRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVC--------- 1570
Query: 1188 KYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYEN 1246
IA I G ++S+ D+ L + +M++ ++ + V +G+ V
Sbjct: 1571 DQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEV---- 1626
Query: 1247 IISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLS 1306
F DA EA + + SK + L+ K+ + + KF +S
Sbjct: 1627 -------FRFQLTLYPDATEGEA----YADMSKVDGKLSFKVGCIQIVYVHKFF----MS 1671
Query: 1307 MDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLA 1366
+ NF+ ++ +T TV A + A S DLA
Sbjct: 1672 LLNFLNNFQTAKEALST--ATVQAAERAASSMK------------------------DLA 1705
Query: 1367 SSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDDESRS-----D 1420
+ +L+++IN+++PV+ IP+ SP ++ LG I ++N F E S D
Sbjct: 1706 QK---SFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSLPPVID 1762
Query: 1421 RLQVEIKDIKL 1431
++ +E+ +KL
Sbjct: 1763 KMNIELTQLKL 1773
Score = 39.7 bits (91), Expect = 0.066
Identities = 86/375 (22%), Positives = 148/375 (39%), Gaps = 50/375 (13%)
Query: 2201 LTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIE 2260
L P L+ V RNL H VP + I G+L S++ SL+ L+ +L NL E E
Sbjct: 1274 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTE 1333
Query: 2261 EF--MRPY-----DLQDPRIHTVLSGEVYTCMCFL---------IDMVNVSLELKDPKRK 2304
+ ++P ++++P + +S +V+ L +D++N+ L + K
Sbjct: 1334 DLDKVKPRVQETGEIKEP-LEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNF---EIK 1389
Query: 2305 EGAGSLARFDFKKCKLLYE------------SFSNQTKSINLVSHSMMAFDTRYAGQKTS 2352
E +L + KK + L+E + T L SM FD + K
Sbjct: 1390 EVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFD--FTDSKGE 1447
Query: 2353 P-GMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSS--CFTVVLNNLRVFLIFDWLLL 2409
P + N + +P T+ F++ DS+ V +L + L + LL
Sbjct: 1448 PLHIINSSNVTDEPLLKMLLTKADSD-GPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1506
Query: 2410 VHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKS-GVVTKRSSLPVSNERHLEVKV 2468
DFL + + S +S ES + P +S + K S +S + ++K+
Sbjct: 1507 FMDFLSSAAPF--------SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKI 1558
Query: 2469 NVTGTEF-VVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHD 2527
F V + D C + I ++ KP+ D L I V + L + H
Sbjct: 1559 TAELNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTD--VFARLKDIIVMNVDLQSIHK 1616
Query: 2528 TALSIVDPVQIQMEL 2542
A+SI+ + +L
Sbjct: 1617 KAVSILGDEVFRFQL 1631
>gi|66348091 vacuolar protein sorting 13C protein isoform 1B [Homo
sapiens]
Length = 3585
Score = 234 bits (596), Expect = 2e-60
Identities = 313/1479 (21%), Positives = 604/1479 (40%), Gaps = 268/1479 (18%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
+LE +VA +LN +LG YV NLN QL + + G V L+NL +K++AL EL++PF+VKAG
Sbjct: 2 VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQ 61
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
I K+TL+IP+ + + V ++ L+L+ P ++ KE+ ++ K+ L +EE
Sbjct: 62 IDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEA 121
Query: 121 WKN--DRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKN 178
+ ++ + E+ + + T++++N+++KI D+H+++ED VT+P P +FG+ +
Sbjct: 122 LQKAAEKDKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGE 181
Query: 179 VSMQNA--------VNEPVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSM 230
+S+ A +NE + + + +LD S YW+V+C++ + ++ + + +
Sbjct: 182 LSLLTANEHWTPCILNEADKIIYKLIRLD--SLSAYWNVNCSMSYQRSREQILDQLKNEI 239
Query: 231 ESR-----SHHYVLEPVFASALLKRN-CSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYR 284
+ ++ Y+ +P+ ASA L N ++ L+ +P++DC+I+++ I ++L++ QY
Sbjct: 240 LTSGNIPPNYQYIFQPISASAKLYMNPYAESELK---TPKLDCNIEIQNIAIELTKPQYL 296
Query: 285 QIMEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFML 343
+++ L+ ++ R +R++KP + + N R WW +A+++ L IR + +W +
Sbjct: 297 SMIDLLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIK 356
Query: 344 HRARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELA 403
+ SY Y NKL +S + ++E+ +E+ + + R Q+
Sbjct: 357 KHRQLLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILAR---------QQAQV 407
Query: 404 ESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPG-WGGWYGQQTPEGNVVEGLSAEQQ 462
E +R Q + + GG WF G WG ++ + +
Sbjct: 408 EVIRSGQKLRKKSADTGEKRGG----------WFSGLWGKKESKK------------KDE 445
Query: 463 EQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNE 522
E IPE I + T ++D +F + +TL P+
Sbjct: 446 ESLIPETI-------------DDLMTPEEKDKLFTAIGYSESTHNLTL-------PKQYV 485
Query: 523 SAFMQLEFSDVKLLAESLPRRNS----SLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKE 578
+ M L KL++ S+ R + +L +++ GL GT V P +
Sbjct: 486 AHIMTL-----KLVSTSVTIRENKNIPEILKIQIIGL--------GTQ----VSQRPGAQ 528
Query: 579 VGRVSQSF------GLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRP 632
+V GL+ S D + ++ +E NP S ++ L V ++P
Sbjct: 529 ALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQP 588
Query: 633 LNIIYNPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTL 692
+ +IY+ + + V +FF K G E ++ A + ++K +T +
Sbjct: 589 VEVIYDAKTVNAVVEFFQSNK------GLDLE---QITSATLMKLEEIKERTATGLTH-- 637
Query: 693 DRLLVGDFIEESKRWTVRLDISAPQVIFPD-DFKFKNPVLVVVDLGRMLLTNTQDNSRRK 751
IE K +R+++ ++ P F + L+++D G L N++D +K
Sbjct: 638 -------IIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGTFQL-NSKDQGLQK 689
Query: 752 SRDGSASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMST 811
+ + S E +
Sbjct: 690 TTNSSLEE-------------------------------------------------IMD 700
Query: 812 KMYERYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYP 871
K Y+++ + ++Q++ R ++ WK + H+++ ++H++L + ++ D +
Sbjct: 701 KAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMA 759
Query: 872 GAVLSGNLPDLKIHINEDK---ISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQRGSLQ 928
+SG LP + + I++ K + L N L ++ + Q+ +G L
Sbjct: 760 RFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSAQSPERQVSSIPIISGGTKGLLG 819
Query: 929 DSVMNLTQSIVLLEQHTREVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTN---A 985
S++ T +++ E Q + + N I++L F
Sbjct: 820 TSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVIL 879
Query: 986 HFVKRPYDAEVSL--TVHGLLLVDTMQTYGADFDLLMASH-KNLSFDIPTGSLRDSRAQS 1042
F K+ + + L V L TM+T FDL + S+ K +S D
Sbjct: 880 EFTKQQKEEDTILVFNVTQLGTEATMRT----FDLTVVSYLKKISLDY------------ 923
Query: 1043 PVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTL 1100
H +G+ S S K L+K+EY PS T
Sbjct: 924 --------HEIEGSKRKPLHLISSS-----DKPGLDLLKVEYIKADKNGPSFQTAFGKTE 970
Query: 1101 QVISLQVNNLDIILNPETIVELIGFLQKSFPKEKDDLSPQPLMTDFERSFREQGTYQSTY 1160
Q + + ++L+++L + +V I +L P + +S + ++ T
Sbjct: 971 QTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAI 1030
Query: 1161 EQNTEVAVEIHRLNLLLLRTVGMANREKYGRKIATASIGGTKVNVSMGS-TFDMNGSLGC 1219
+ + + RL L + EK IA I G ++S+ S + L
Sbjct: 1031 VSSRDSDIIDFRLFAKLNAFCVIVCNEK--NNIAEIKIQGLDSSLSLQSRKQSLFARLEN 1088
Query: 1220 LQLMDLTQDNVKNQYVVSIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSK 1279
+ + D+ V + V +GN V N+ D+ DA TE +T + SK
Sbjct: 1089 IIVTDVDPKTVHKKAVSIMGNEVFRFNL--DL---------YPDA--TEGDLYT--DMSK 1133
Query: 1280 QECFLNLKMASLHYNHSAKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEM 1339
+ L+L + + + KFL L NF ++A ++ A +
Sbjct: 1134 VDGVLSLNVGCIQIVYLHKFLMSLL--------NFLNNFQTAKESLSAATAQAAERAATS 1185
Query: 1340 VSLFETPRKTREPFILEENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLV 1399
V DLA + ++ +NI++++PV+ IP+ S +V
Sbjct: 1186 VK----------------------DLAQR---SFRVSINIDLKAPVIVIPQSSISTNAVV 1220
Query: 1400 GHLGQIFIQN-FVAGDDESR-----SDRLQVEIKDIKLY 1432
LG I + N F DE DR+ V++ + LY
Sbjct: 1221 VDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLY 1259
Score = 139 bits (350), Expect = 6e-32
Identities = 117/443 (26%), Positives = 204/443 (46%), Gaps = 48/443 (10%)
Query: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887
L+GI + + Q + L + +QVDNQL G P + + V P + E P + V
Sbjct: 3141 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDV 3200
Query: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAESEVEK-----YDE 3942
+ + ++ + +K+ M+ Q ++I++ L +++ F + E E+ +
Sbjct: 3201 SVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFT-PTTDPEAERRRTKLIQQ 3259
Query: 3943 NLHEKTAEQGGTP-----IRYYFENLKISIPQIKLSVFT------SNKLPLDLKALKS-- 3989
++ AE T I +FE+ IS ++ LS+ S+K ++ A+ S
Sbjct: 3260 DIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHSVN 3319
Query: 3990 ----TLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDF 4045
++G L +D + L + + + ++ +I +++H+ E+ L Q ++ +D
Sbjct: 3320 LLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDV 3379
Query: 4046 LGNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFA 4088
LGNP GL+ +SEGV L G V G L + G + ++
Sbjct: 3380 LGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3439
Query: 4089 GTLSDGLGK-TMDNRHQSE-REYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEG 4146
G++ GL TMD +Q + RE + G+ L G G G++GG+T +IT VEG
Sbjct: 3440 GSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEG 3499
Query: 4147 VKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPR 4206
K E G +GF G+GKGLVG V +P G +D AS T Q ++ A + + +R PR
Sbjct: 3500 AKKE-GAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAEST---EEVSSLRPPR 3555
Query: 4207 CCTGPQGLLPRYSESQAEGQEQL 4229
G++ Y ++EG + L
Sbjct: 3556 -LIHEDGIIRPYDRQESEGSDLL 3577
Score = 84.3 bits (207), Expect = 2e-15
Identities = 65/289 (22%), Positives = 140/289 (48%), Gaps = 17/289 (5%)
Query: 1784 LVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHA 1843
L+ + DK P F +++ + +++ V F+ L++L+ Q V +++ +D+ +
Sbjct: 947 LLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQS 1006
Query: 1844 MRLPPEGILHNVKLE-----PHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANV 1898
+ + E + K + P A + S D ++ +L K+++ +++ + +A+ +
Sbjct: 1007 ISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKI 1066
Query: 1899 SKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPL 1958
L + L + +L + ++ ++D+ +++ + G E F Y PD
Sbjct: 1067 QGLDSSLSLQSRKQSLFARLENIIVTDVDPK-TVHKKAVSIMGNEVFRFNLDLY--PDAT 1123
Query: 1959 L------RREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIEG 2009
+ D +SL + +Q V+ +F ++ F+ +F ++ L Q A
Sbjct: 1124 EGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAA 1183
Query: 2010 QTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058
+V+D AQR RV ++I+ APV++IP+SS S N +V +LG ++V N+F
Sbjct: 1184 TSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQF 1232
Score = 82.8 bits (203), Expect = 7e-15
Identities = 66/305 (21%), Positives = 147/305 (48%), Gaps = 20/305 (6%)
Query: 1770 EPKILVGKSKF-DDSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVV 1828
EP ++ S D+ L+ + + D PEF + ++ + + V F LD+++ L+ +
Sbjct: 1447 EPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1506
Query: 1829 ILDF------FGIGSTADNHAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSL 1882
+DF F S+++ + P G ++ ++ +S S +D + K+ ++++
Sbjct: 1507 FMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQ-KDVFDLKITAELNAF 1565
Query: 1883 SLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGE 1942
++ + +A + + A + + + + + + ++ +++ + G+
Sbjct: 1566 NVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQS-IHKKAVSILGD 1624
Query: 1943 EALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQL 1996
E FQ Y PD + D ++S ++ +Q V+ +F ++ F+ +F
Sbjct: 1625 EVFRFQLTLY--PDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1682
Query: 1997 QDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLK 2053
++ L Q A +++D AQ+ R+L+DI APV++IP+SS S N ++A+LG ++
Sbjct: 1683 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1742
Query: 2054 VKNKF 2058
V+NKF
Sbjct: 1743 VENKF 1747
Score = 53.9 bits (128), Expect = 3e-06
Identities = 96/441 (21%), Positives = 173/441 (39%), Gaps = 70/441 (15%)
Query: 3151 HTIYLLPTVVICNLLPCELDFYVKGMPINGTLKPGKEA-ALHTADTSQNIELGVSLENFP 3209
+ I+L P++ + NLLP L + ++G L G A LH+ + + +EL
Sbjct: 2619 YIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTADVLHSRISGEIMEL-------- 2670
Query: 3210 LCKELLIPPGTQNYMVRMRLYDV------------NRRQLNLTIRIVCRAEGSLKIF-IS 3256
+L+ +N+ R+ D + + + + R GS + +
Sbjct: 2671 ----VLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRIGSRMVLSVF 2726
Query: 3257 APYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKE--QPNLCTMRIG 3314
+PYWLINKT L +R ++ F + +LF + K N ++I
Sbjct: 2727 SPYWLINKTTRVLQYRSEDIHVKHPADFRD--------IILFSFKKKNIFTKNKVQLKIS 2778
Query: 3315 RGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIF 3374
W FSLD +K + Y +G+ +K + + +V
Sbjct: 2779 TS-------AWSSSFSLDTVGSYGCVKCPAN----NMEYLVGVSIK--MSSFNLSRIVTL 2825
Query: 3375 APRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLM 3434
P + NKSS +L + + G N YI++ S + WP + LCVR
Sbjct: 2826 TPFCTIANKSSLELEVGEIA-SDGSMPTNKWNYIAS---SECLPFWPES-LSGKLCVR-- 2878
Query: 3435 DVPNCIWSGG--FEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPF 3492
V C S F ++N +++ D G + V++ + I+FSD + P
Sbjct: 2879 -VVGCEGSSKPFFYNRQDNGTLLSLEDLNGG---ILVDVNTAEHSTVITFSDYHEGSAPA 2934
Query: 3493 RIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT-VKGAGSSEI- 3549
I N + ++ + Q G E + + P + +AW +PT +T T G ++
Sbjct: 2935 LIMNHTPWDILTYKQSGSPEEMV---LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLL 2991
Query: 3550 --NCNMNDFQDNRQLYYENFI 3568
C + N Q+++ +F+
Sbjct: 2992 KDGCGQFPYDANIQIHWVSFL 3012
Score = 52.0 bits (123), Expect = 1e-05
Identities = 122/611 (19%), Positives = 236/611 (38%), Gaps = 138/611 (22%)
Query: 848 VVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFALLTTPEMK 907
++ N+ + R L + K P + G+L + + +N++ ++ L F +LT E
Sbjct: 1274 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLL---FRILT--ENL 1328
Query: 908 TSDTQIKEKIFPQEEQRG--------SLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEF 959
T+ +K+ P+ ++ G S+ V + ++ + R V + + LL E
Sbjct: 1329 CEGTEDLDKVKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEI 1388
Query: 960 K--VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFD 1017
K V + E GR + L V + YD +T L +MQ + DF
Sbjct: 1389 KEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYD----MTAKAYLKKISMQCF--DFT 1442
Query: 1018 LLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQE 1077
DS+ + P+ N +++TD E
Sbjct: 1443 -------------------DSKGE-PLHIINSSNVTD----------------------E 1460
Query: 1078 SLIKLEYQFVSSECPSMNL--DSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKD 1135
L+K+ S+ P DST Q + + +LD++L+ E ++ + FL + P +
Sbjct: 1461 PLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPFSEP 1520
Query: 1136 DLSPQ-----PLMTDFERSFREQGTYQSTYEQNT---EVAVEIHRLNLLLLRTVGMANRE 1187
S + PL+ + RS + + +++ ++ E++ N+ +
Sbjct: 1521 SSSEKESELKPLVGE-SRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVC--------- 1570
Query: 1188 KYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYEN 1246
IA I G ++S+ D+ L + +M++ ++ + V +G+ V
Sbjct: 1571 DQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEV---- 1626
Query: 1247 IISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLS 1306
F DA EA + + SK + L+ K+ + + KF +S
Sbjct: 1627 -------FRFQLTLYPDATEGEA----YADMSKVDGKLSFKVGCIQIVYVHKFF----MS 1671
Query: 1307 MDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLA 1366
+ NF+ ++ +T TV A + A S DLA
Sbjct: 1672 LLNFLNNFQTAKEALST--ATVQAAERAASSMK------------------------DLA 1705
Query: 1367 SSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDDESRS-----D 1420
+ +L+++IN+++PV+ IP+ SP ++ LG I ++N F E S D
Sbjct: 1706 QK---SFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSLPPVID 1762
Query: 1421 RLQVEIKDIKL 1431
++ +E+ +KL
Sbjct: 1763 KMNIELTQLKL 1773
Score = 39.7 bits (91), Expect = 0.066
Identities = 86/375 (22%), Positives = 148/375 (39%), Gaps = 50/375 (13%)
Query: 2201 LTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIE 2260
L P L+ V RNL H VP + I G+L S++ SL+ L+ +L NL E E
Sbjct: 1274 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTE 1333
Query: 2261 EF--MRPY-----DLQDPRIHTVLSGEVYTCMCFL---------IDMVNVSLELKDPKRK 2304
+ ++P ++++P + +S +V+ L +D++N+ L + K
Sbjct: 1334 DLDKVKPRVQETGEIKEP-LEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNF---EIK 1389
Query: 2305 EGAGSLARFDFKKCKLLYE------------SFSNQTKSINLVSHSMMAFDTRYAGQKTS 2352
E +L + KK + L+E + T L SM FD + K
Sbjct: 1390 EVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFD--FTDSKGE 1447
Query: 2353 P-GMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSS--CFTVVLNNLRVFLIFDWLLL 2409
P + N + +P T+ F++ DS+ V +L + L + LL
Sbjct: 1448 PLHIINSSNVTDEPLLKMLLTKADSD-GPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1506
Query: 2410 VHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKS-GVVTKRSSLPVSNERHLEVKV 2468
DFL + + S +S ES + P +S + K S +S + ++K+
Sbjct: 1507 FMDFLSSAAPF--------SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKI 1558
Query: 2469 NVTGTEF-VVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHD 2527
F V + D C + I ++ KP+ D L I V + L + H
Sbjct: 1559 TAELNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTD--VFARLKDIIVMNVDLQSIHK 1616
Query: 2528 TALSIVDPVQIQMEL 2542
A+SI+ + +L
Sbjct: 1617 KAVSILGDEVFRFQL 1631
>gi|66347845 vacuolar protein sorting 13C protein isoform 2B [Homo
sapiens]
Length = 3628
Score = 218 bits (555), Expect = 1e-55
Identities = 320/1522 (21%), Positives = 604/1522 (39%), Gaps = 311/1522 (20%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
+LE +VA +LN +LG YV NLN QL + + G V L+NL +K++AL EL++PF+VKAG
Sbjct: 2 VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQ 61
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLI---GAPEKIQDFNDEKE----KLLERERKKAL 113
I K+TL+IP+ + + V ++ L+L+ GA K +EK K E R +
Sbjct: 62 IDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEA 121
Query: 114 LQALEEKW------------------KNDRQQKGESYWY--------------------S 135
LQ EK K R++K + +
Sbjct: 122 LQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKDT 181
Query: 136 VTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQNA--------VNE 187
+ T++++N+++KI D+H+++ED VT+P P +FG+ + +S+ A +NE
Sbjct: 182 FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
Query: 188 PVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESR-----SHHYVLEPV 242
+ + + +LD S YW+V+C++ + ++ + + + + ++ Y+ +P+
Sbjct: 242 ADKIIYKLIRLD--SLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPI 299
Query: 243 FASALLKRN-CSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVK 301
ASA L N ++ L++ P++DC+I+++ I ++L++ QY +++ L+ ++ R
Sbjct: 300 SASAKLYMNPYAESELKT---PKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAP 356
Query: 302 FRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL 360
+R++KP + + N R WW +A+++ L IR + +W + + SY Y NKL
Sbjct: 357 YRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKL 416
Query: 361 KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA 420
+S + ++E+ +E+ + + R Q+ E +R Q +
Sbjct: 417 TQSKVSEEIQKEIQDLEKTLDVFNIILAR---------QQAQVEVIRSGQKLRKKSADTG 467
Query: 421 PEPGGGSGMLQYLQSWFPG-WGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDP 479
+ GG WF G WG ++ + +E IPE I
Sbjct: 468 EKRGG----------WFSGLWGKKESKK------------KDEESLIPETI--------- 496
Query: 480 TADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAES 539
+ T ++D +F + +TL P+ + M L KL++ S
Sbjct: 497 ----DDLMTPEEKDKLFTAIGYSESTHNLTL-------PKQYVAHIMTL-----KLVSTS 540
Query: 540 LPRRNS----SLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSF------GLQ 589
+ R + +L +++ GL GT V P + +V GL+
Sbjct: 541 VTIRENKNIPEILKIQIIGL--------GTQ----VSQRPGAQALKVEAKLEHWYITGLR 588
Query: 590 TTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFF 649
S D + ++ +E NP S ++ L V ++P+ +IY+ + + V +FF
Sbjct: 589 QQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFF 648
Query: 650 YKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTV 709
K G E ++ A + ++K +T + IE K +
Sbjct: 649 QSNK------GLDLE---QITSATLMKLEEIKERTATGLTH---------IIETRKVLDL 690
Query: 710 RLDISAPQVIFPD-DFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEY 768
R+++ ++ P F + L+++D G L N++D +K+ + S E
Sbjct: 691 RINLKPSYLVVPQTGFHHEKSDLLILDFGTFQL-NSKDQGLQKTTNSSLEE--------- 740
Query: 769 KTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMV 828
+ K Y+++ + ++Q++
Sbjct: 741 ----------------------------------------IMDKAYDKFDVEIKNVQLLF 760
Query: 829 GRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINE 888
R ++ WK + H+++ ++H++L + ++ D + +SG LP + + I++
Sbjct: 761 ARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISD 819
Query: 889 DK---ISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHT 945
K + L N L ++ + Q+ +G L S++ T +++
Sbjct: 820 QKMKDVLYLMNSIPLPQKSSAQSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYF 879
Query: 946 REVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTN---AHFVKRPYDAEVSL--TV 1000
E Q + + N I++L F F K+ + + L V
Sbjct: 880 DAEDGEPQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNV 939
Query: 1001 HGLLLVDTMQTYGADFDLLMASH-KNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLN 1059
L TM+T FDL + S+ K +S D H +G+
Sbjct: 940 TQLGTEATMRT----FDLTVVSYLKKISLDY--------------------HEIEGSKRK 975
Query: 1060 DRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTLQVISLQVNNLDIILNPE 1117
S S K L+K+EY PS T Q + + ++L+++L +
Sbjct: 976 PLHLISSS-----DKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQ 1030
Query: 1118 TIVELIGFLQKSFPKEKDDLSPQPLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLL 1177
+V I +L P + +S + ++ T + + + RL L
Sbjct: 1031 ALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKL 1090
Query: 1178 LRTVGMANREKYGRKIATASIGGTKVNVSMGS-TFDMNGSLGCLQLMDLTQDNVKNQYVV 1236
+ EK IA I G ++S+ S + L + + D+ V + V
Sbjct: 1091 NAFCVIVCNEK--NNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPKTVHKKAVS 1148
Query: 1237 SIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHS 1296
+GN V N+ D+ DA TE +T + SK + L+L + + +
Sbjct: 1149 IMGNEVFRFNL--DL---------YPDA--TEGDLYT--DMSKVDGVLSLNVGCIQIVYL 1193
Query: 1297 AKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILE 1356
KFL L NF ++A ++ A + V
Sbjct: 1194 HKFLMSLL--------NFLNNFQTAKESLSAATAQAAERAATSVK--------------- 1230
Query: 1357 ENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDD 1415
DLA + ++ +NI++++PV+ IP+ S +V LG I + N F D
Sbjct: 1231 -------DLAQR---SFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSD 1280
Query: 1416 ESR-----SDRLQVEIKDIKLY 1432
E DR+ V++ + LY
Sbjct: 1281 EDYLNPPVIDRMDVQLTKLTLY 1302
Score = 139 bits (350), Expect = 6e-32
Identities = 117/443 (26%), Positives = 204/443 (46%), Gaps = 48/443 (10%)
Query: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887
L+GI + + Q + L + +QVDNQL G P + + V P + E P + V
Sbjct: 3184 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDV 3243
Query: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAESEVEK-----YDE 3942
+ + ++ + +K+ M+ Q ++I++ L +++ F + E E+ +
Sbjct: 3244 SVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFT-PTTDPEAERRRTKLIQQ 3302
Query: 3943 NLHEKTAEQGGTP-----IRYYFENLKISIPQIKLSVFT------SNKLPLDLKALKS-- 3989
++ AE T I +FE+ IS ++ LS+ S+K ++ A+ S
Sbjct: 3303 DIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHSVN 3362
Query: 3990 ----TLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDF 4045
++G L +D + L + + + ++ +I +++H+ E+ L Q ++ +D
Sbjct: 3363 LLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDV 3422
Query: 4046 LGNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFA 4088
LGNP GL+ +SEGV L G V G L + G + ++
Sbjct: 3423 LGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3482
Query: 4089 GTLSDGLGK-TMDNRHQSE-REYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEG 4146
G++ GL TMD +Q + RE + G+ L G G G++GG+T +IT VEG
Sbjct: 3483 GSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEG 3542
Query: 4147 VKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPR 4206
K E G +GF G+GKGLVG V +P G +D AS T Q ++ A + + +R PR
Sbjct: 3543 AKKE-GAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAEST---EEVSSLRPPR 3598
Query: 4207 CCTGPQGLLPRYSESQAEGQEQL 4229
G++ Y ++EG + L
Sbjct: 3599 -LIHEDGIIRPYDRQESEGSDLL 3620
Score = 84.3 bits (207), Expect = 2e-15
Identities = 65/289 (22%), Positives = 140/289 (48%), Gaps = 17/289 (5%)
Query: 1784 LVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHA 1843
L+ + DK P F +++ + +++ V F+ L++L+ Q V +++ +D+ +
Sbjct: 990 LLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQS 1049
Query: 1844 MRLPPEGILHNVKLE-----PHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANV 1898
+ + E + K + P A + S D ++ +L K+++ +++ + +A+ +
Sbjct: 1050 ISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKI 1109
Query: 1899 SKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPL 1958
L + L + +L + ++ ++D+ +++ + G E F Y PD
Sbjct: 1110 QGLDSSLSLQSRKQSLFARLENIIVTDVDPK-TVHKKAVSIMGNEVFRFNLDLY--PDAT 1166
Query: 1959 L------RREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIEG 2009
+ D +SL + +Q V+ +F ++ F+ +F ++ L Q A
Sbjct: 1167 EGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAA 1226
Query: 2010 QTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058
+V+D AQR RV ++I+ APV++IP+SS S N +V +LG ++V N+F
Sbjct: 1227 TSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQF 1275
Score = 82.8 bits (203), Expect = 7e-15
Identities = 66/305 (21%), Positives = 147/305 (48%), Gaps = 20/305 (6%)
Query: 1770 EPKILVGKSKF-DDSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVV 1828
EP ++ S D+ L+ + + D PEF + ++ + + V F LD+++ L+ +
Sbjct: 1490 EPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1549
Query: 1829 ILDF------FGIGSTADNHAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSL 1882
+DF F S+++ + P G ++ ++ +S S +D + K+ ++++
Sbjct: 1550 FMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQ-KDVFDLKITAELNAF 1608
Query: 1883 SLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGE 1942
++ + +A + + A + + + + + + ++ +++ + G+
Sbjct: 1609 NVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQS-IHKKAVSILGD 1667
Query: 1943 EALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQL 1996
E FQ Y PD + D ++S ++ +Q V+ +F ++ F+ +F
Sbjct: 1668 EVFRFQLTLY--PDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1725
Query: 1997 QDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLK 2053
++ L Q A +++D AQ+ R+L+DI APV++IP+SS S N ++A+LG ++
Sbjct: 1726 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1785
Query: 2054 VKNKF 2058
V+NKF
Sbjct: 1786 VENKF 1790
Score = 53.9 bits (128), Expect = 3e-06
Identities = 96/441 (21%), Positives = 173/441 (39%), Gaps = 70/441 (15%)
Query: 3151 HTIYLLPTVVICNLLPCELDFYVKGMPINGTLKPGKEA-ALHTADTSQNIELGVSLENFP 3209
+ I+L P++ + NLLP L + ++G L G A LH+ + + +EL
Sbjct: 2662 YIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTADVLHSRISGEIMEL-------- 2713
Query: 3210 LCKELLIPPGTQNYMVRMRLYDV------------NRRQLNLTIRIVCRAEGSLKIF-IS 3256
+L+ +N+ R+ D + + + + R GS + +
Sbjct: 2714 ----VLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRIGSRMVLSVF 2769
Query: 3257 APYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKE--QPNLCTMRIG 3314
+PYWLINKT L +R ++ F + +LF + K N ++I
Sbjct: 2770 SPYWLINKTTRVLQYRSEDIHVKHPADFRD--------IILFSFKKKNIFTKNKVQLKIS 2821
Query: 3315 RGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIF 3374
W FSLD +K + Y +G+ +K + + +V
Sbjct: 2822 TS-------AWSSSFSLDTVGSYGCVKCPAN----NMEYLVGVSIK--MSSFNLSRIVTL 2868
Query: 3375 APRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLM 3434
P + NKSS +L + + G N YI++ S + WP + LCVR
Sbjct: 2869 TPFCTIANKSSLELEVGEIA-SDGSMPTNKWNYIAS---SECLPFWPES-LSGKLCVR-- 2921
Query: 3435 DVPNCIWSGG--FEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPF 3492
V C S F ++N +++ D G + V++ + I+FSD + P
Sbjct: 2922 -VVGCEGSSKPFFYNRQDNGTLLSLEDLNGG---ILVDVNTAEHSTVITFSDYHEGSAPA 2977
Query: 3493 RIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT-VKGAGSSEI- 3549
I N + ++ + Q G E + + P + +AW +PT +T T G ++
Sbjct: 2978 LIMNHTPWDILTYKQSGSPEEMV---LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLL 3034
Query: 3550 --NCNMNDFQDNRQLYYENFI 3568
C + N Q+++ +F+
Sbjct: 3035 KDGCGQFPYDANIQIHWVSFL 3055
Score = 52.0 bits (123), Expect = 1e-05
Identities = 122/611 (19%), Positives = 236/611 (38%), Gaps = 138/611 (22%)
Query: 848 VVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFALLTTPEMK 907
++ N+ + R L + K P + G+L + + +N++ ++ L F +LT E
Sbjct: 1317 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLL---FRILT--ENL 1371
Query: 908 TSDTQIKEKIFPQEEQRG--------SLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEF 959
T+ +K+ P+ ++ G S+ V + ++ + R V + + LL E
Sbjct: 1372 CEGTEDLDKVKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEI 1431
Query: 960 K--VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFD 1017
K V + E GR + L V + YD +T L +MQ + DF
Sbjct: 1432 KEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYD----MTAKAYLKKISMQCF--DFT 1485
Query: 1018 LLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQE 1077
DS+ + P+ N +++TD E
Sbjct: 1486 -------------------DSKGE-PLHIINSSNVTD----------------------E 1503
Query: 1078 SLIKLEYQFVSSECPSMNL--DSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKD 1135
L+K+ S+ P DST Q + + +LD++L+ E ++ + FL + P +
Sbjct: 1504 PLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPFSEP 1563
Query: 1136 DLSPQ-----PLMTDFERSFREQGTYQSTYEQNT---EVAVEIHRLNLLLLRTVGMANRE 1187
S + PL+ + RS + + +++ ++ E++ N+ +
Sbjct: 1564 SSSEKESELKPLVGE-SRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVC--------- 1613
Query: 1188 KYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYEN 1246
IA I G ++S+ D+ L + +M++ ++ + V +G+ V
Sbjct: 1614 DQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEV---- 1669
Query: 1247 IISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLS 1306
F DA EA + + SK + L+ K+ + + KF +S
Sbjct: 1670 -------FRFQLTLYPDATEGEA----YADMSKVDGKLSFKVGCIQIVYVHKFF----MS 1714
Query: 1307 MDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLA 1366
+ NF+ ++ +T TV A + A S DLA
Sbjct: 1715 LLNFLNNFQTAKEALST--ATVQAAERAASSMK------------------------DLA 1748
Query: 1367 SSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDDESRS-----D 1420
+ +L+++IN+++PV+ IP+ SP ++ LG I ++N F E S D
Sbjct: 1749 QK---SFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSLPPVID 1805
Query: 1421 RLQVEIKDIKL 1431
++ +E+ +KL
Sbjct: 1806 KMNIELTQLKL 1816
Score = 39.7 bits (91), Expect = 0.066
Identities = 86/375 (22%), Positives = 148/375 (39%), Gaps = 50/375 (13%)
Query: 2201 LTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIE 2260
L P L+ V RNL H VP + I G+L S++ SL+ L+ +L NL E E
Sbjct: 1317 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTE 1376
Query: 2261 EF--MRPY-----DLQDPRIHTVLSGEVYTCMCFL---------IDMVNVSLELKDPKRK 2304
+ ++P ++++P + +S +V+ L +D++N+ L + K
Sbjct: 1377 DLDKVKPRVQETGEIKEP-LEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNF---EIK 1432
Query: 2305 EGAGSLARFDFKKCKLLYE------------SFSNQTKSINLVSHSMMAFDTRYAGQKTS 2352
E +L + KK + L+E + T L SM FD + K
Sbjct: 1433 EVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFD--FTDSKGE 1490
Query: 2353 P-GMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSS--CFTVVLNNLRVFLIFDWLLL 2409
P + N + +P T+ F++ DS+ V +L + L + LL
Sbjct: 1491 PLHIINSSNVTDEPLLKMLLTKADSD-GPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1549
Query: 2410 VHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKS-GVVTKRSSLPVSNERHLEVKV 2468
DFL + + S +S ES + P +S + K S +S + ++K+
Sbjct: 1550 FMDFLSSAAPF--------SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKI 1601
Query: 2469 NVTGTEF-VVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHD 2527
F V + D C + I ++ KP+ D L I V + L + H
Sbjct: 1602 TAELNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTD--VFARLKDIIVMNVDLQSIHK 1659
Query: 2528 TALSIVDPVQIQMEL 2542
A+SI+ + +L
Sbjct: 1660 KAVSILGDEVFRFQL 1674
>gi|66347828 vacuolar protein sorting 13C protein isoform 2A [Homo
sapiens]
Length = 3753
Score = 218 bits (555), Expect = 1e-55
Identities = 320/1522 (21%), Positives = 604/1522 (39%), Gaps = 311/1522 (20%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
+LE +VA +LN +LG YV NLN QL + + G V L+NL +K++AL EL++PF+VKAG
Sbjct: 2 VLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQ 61
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLI---GAPEKIQDFNDEKE----KLLERERKKAL 113
I K+TL+IP+ + + V ++ L+L+ GA K +EK K E R +
Sbjct: 62 IDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEA 121
Query: 114 LQALEEKW------------------KNDRQQKGESYWY--------------------S 135
LQ EK K R++K + +
Sbjct: 122 LQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKDT 181
Query: 136 VTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQNA--------VNE 187
+ T++++N+++KI D+H+++ED VT+P P +FG+ + +S+ A +NE
Sbjct: 182 FVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILNE 241
Query: 188 PVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESR-----SHHYVLEPV 242
+ + + +LD S YW+V+C++ + ++ + + + + ++ Y+ +P+
Sbjct: 242 ADKIIYKLIRLD--SLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPI 299
Query: 243 FASALLKRN-CSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVK 301
ASA L N ++ L++ P++DC+I+++ I ++L++ QY +++ L+ ++ R
Sbjct: 300 SASAKLYMNPYAESELKT---PKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAP 356
Query: 302 FRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHRARDAVSYTDKYFNKL 360
+R++KP + + N R WW +A+++ L IR + +W + + SY Y NKL
Sbjct: 357 YRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKL 416
Query: 361 KGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGA 420
+S + ++E+ +E+ + + R Q+ E +R Q +
Sbjct: 417 TQSKVSEEIQKEIQDLEKTLDVFNIILAR---------QQAQVEVIRSGQKLRKKSADTG 467
Query: 421 PEPGGGSGMLQYLQSWFPG-WGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDP 479
+ GG WF G WG ++ + +E IPE I
Sbjct: 468 EKRGG----------WFSGLWGKKESKK------------KDEESLIPETI--------- 496
Query: 480 TADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAES 539
+ T ++D +F + +TL P+ + M L KL++ S
Sbjct: 497 ----DDLMTPEEKDKLFTAIGYSESTHNLTL-------PKQYVAHIMTL-----KLVSTS 540
Query: 540 LPRRNS----SLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSF------GLQ 589
+ R + +L +++ GL GT V P + +V GL+
Sbjct: 541 VTIRENKNIPEILKIQIIGL--------GTQ----VSQRPGAQALKVEAKLEHWYITGLR 588
Query: 590 TTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIYNPQAIKKVADFF 649
S D + ++ +E NP S ++ L V ++P+ +IY+ + + V +FF
Sbjct: 589 QQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFF 648
Query: 650 YKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTV 709
K G E ++ A + ++K +T + IE K +
Sbjct: 649 QSNK------GLDLE---QITSATLMKLEEIKERTATGLTH---------IIETRKVLDL 690
Query: 710 RLDISAPQVIFPD-DFKFKNPVLVVVDLGRMLLTNTQDNSRRKSRDGSASEETQFSDDEY 768
R+++ ++ P F + L+++D G L N++D +K+ + S E
Sbjct: 691 RINLKPSYLVVPQTGFHHEKSDLLILDFGTFQL-NSKDQGLQKTTNSSLEE--------- 740
Query: 769 KTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMV 828
+ K Y+++ + ++Q++
Sbjct: 741 ----------------------------------------IMDKAYDKFDVEIKNVQLLF 760
Query: 829 GRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINE 888
R ++ WK + H+++ ++H++L + ++ D + +SG LP + + I++
Sbjct: 761 ARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISD 819
Query: 889 DK---ISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHT 945
K + L N L ++ + Q+ +G L S++ T +++
Sbjct: 820 QKMKDVLYLMNSIPLPQKSSAQSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYF 879
Query: 946 REVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTN---AHFVKRPYDAEVSL--TV 1000
E Q + + N I++L F F K+ + + L V
Sbjct: 880 DAEDGEPQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNV 939
Query: 1001 HGLLLVDTMQTYGADFDLLMASH-KNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLN 1059
L TM+T FDL + S+ K +S D H +G+
Sbjct: 940 TQLGTEATMRT----FDLTVVSYLKKISLDY--------------------HEIEGSKRK 975
Query: 1060 DRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTLQVISLQVNNLDIILNPE 1117
S S K L+K+EY PS T Q + + ++L+++L +
Sbjct: 976 PLHLISSS-----DKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQ 1030
Query: 1118 TIVELIGFLQKSFPKEKDDLSPQPLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLL 1177
+V I +L P + +S + ++ T + + + RL L
Sbjct: 1031 ALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKL 1090
Query: 1178 LRTVGMANREKYGRKIATASIGGTKVNVSMGS-TFDMNGSLGCLQLMDLTQDNVKNQYVV 1236
+ EK IA I G ++S+ S + L + + D+ V + V
Sbjct: 1091 NAFCVIVCNEK--NNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPKTVHKKAVS 1148
Query: 1237 SIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHS 1296
+GN V N+ D+ DA TE +T + SK + L+L + + +
Sbjct: 1149 IMGNEVFRFNL--DL---------YPDA--TEGDLYT--DMSKVDGVLSLNVGCIQIVYL 1193
Query: 1297 AKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILE 1356
KFL L NF ++A ++ A + V
Sbjct: 1194 HKFLMSLL--------NFLNNFQTAKESLSAATAQAAERAATSVK--------------- 1230
Query: 1357 ENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDD 1415
DLA + ++ +NI++++PV+ IP+ S +V LG I + N F D
Sbjct: 1231 -------DLAQR---SFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSD 1280
Query: 1416 ESR-----SDRLQVEIKDIKLY 1432
E DR+ V++ + LY
Sbjct: 1281 EDYLNPPVIDRMDVQLTKLTLY 1302
Score = 144 bits (362), Expect = 2e-33
Identities = 139/574 (24%), Positives = 258/574 (44%), Gaps = 63/574 (10%)
Query: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887
L+GI + + Q + L + +QVDNQL G P + + V P + E P + V
Sbjct: 3184 LSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDV 3243
Query: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQAESEVEK-----YDE 3942
+ + ++ + +K+ M+ Q ++I++ L +++ F + E E+ +
Sbjct: 3244 SVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFT-PTTDPEAERRRTKLIQQ 3302
Query: 3943 NLHEKTAEQGGTP-----IRYYFENLKISIPQIKLSVFT------SNKLPLDLKALKS-- 3989
++ AE T I +FE+ IS ++ LS+ S+K ++ A+ S
Sbjct: 3303 DIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHSVN 3362
Query: 3990 ----TLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDF 4045
++G L +D + L + + + ++ +I +++H+ E+ L Q ++ +D
Sbjct: 3363 LLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDV 3422
Query: 4046 LGNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFA 4088
LGNP GL+ +SEGV L G V G L + G + ++
Sbjct: 3423 LGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRIT 3482
Query: 4089 GTLSDGLGK-TMDNRHQSE-REYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEG 4146
G++ GL TMD +Q + RE + G+ L G G G++GG+T +IT VEG
Sbjct: 3483 GSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEG 3542
Query: 4147 VKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPR 4206
K E G +GF G+GKGLVG V +P G +D AS T Q ++ A + + +R PR
Sbjct: 3543 AKKE-GAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAEST---EEVSSLRPPR 3598
Query: 4207 CCTGPQGLLPRYSESQAEGQEQLFKLTDNIQDE---FFIAVENIDSYCVLISSKAVYFLK 4263
G++ Y ++EG + L ++ E + A+ ++++++ V +K
Sbjct: 3599 -LIHEDGIIRPYDRQESEGSDLLENHIKKLEGETYRYHCAIPGSKKTILMVTNRRVLCIK 3657
Query: 4264 SGDYVDREAIFLEVKYDD-LYHCLVSKDHGKVYVQ---VTKKAVSTSSGVSIPGPSHQKP 4319
+ + + + ++D ++ VS++ K+ V+ + K S + G
Sbjct: 3658 EVEILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDSANQGC--------VR 3709
Query: 4320 MVHVKSEVLAVKLSQEINYAKSLYYEQQLMLRLS 4353
V++K A + I A+S +Q+LM + S
Sbjct: 3710 KVYLKDTATAERACNAIEDAQSTRQQQKLMKQSS 3743
Score = 84.3 bits (207), Expect = 2e-15
Identities = 65/289 (22%), Positives = 140/289 (48%), Gaps = 17/289 (5%)
Query: 1784 LVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADNHA 1843
L+ + DK P F +++ + +++ V F+ L++L+ Q V +++ +D+ +
Sbjct: 990 LLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQS 1049
Query: 1844 MRLPPEGILHNVKLE-----PHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANV 1898
+ + E + K + P A + S D ++ +L K+++ +++ + +A+ +
Sbjct: 1050 ISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKI 1109
Query: 1899 SKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDPL 1958
L + L + +L + ++ ++D+ +++ + G E F Y PD
Sbjct: 1110 QGLDSSLSLQSRKQSLFARLENIIVTDVDPK-TVHKKAVSIMGNEVFRFNLDLY--PDAT 1166
Query: 1959 L------RREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIEG 2009
+ D +SL + +Q V+ +F ++ F+ +F ++ L Q A
Sbjct: 1167 EGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAA 1226
Query: 2010 QTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058
+V+D AQR RV ++I+ APV++IP+SS S N +V +LG ++V N+F
Sbjct: 1227 TSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQF 1275
Score = 82.8 bits (203), Expect = 7e-15
Identities = 66/305 (21%), Positives = 147/305 (48%), Gaps = 20/305 (6%)
Query: 1770 EPKILVGKSKF-DDSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVV 1828
EP ++ S D+ L+ + + D PEF + ++ + + V F LD+++ L+ +
Sbjct: 1490 EPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1549
Query: 1829 ILDF------FGIGSTADNHAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSL 1882
+DF F S+++ + P G ++ ++ +S S +D + K+ ++++
Sbjct: 1550 FMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQ-KDVFDLKITAELNAF 1608
Query: 1883 SLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGE 1942
++ + +A + + A + + + + + + ++ +++ + G+
Sbjct: 1609 NVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQS-IHKKAVSILGD 1667
Query: 1943 EALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQL 1996
E FQ Y PD + D ++S ++ +Q V+ +F ++ F+ +F
Sbjct: 1668 EVFRFQLTLY--PDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1725
Query: 1997 QDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLK 2053
++ L Q A +++D AQ+ R+L+DI APV++IP+SS S N ++A+LG ++
Sbjct: 1726 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1785
Query: 2054 VKNKF 2058
V+NKF
Sbjct: 1786 VENKF 1790
Score = 53.9 bits (128), Expect = 3e-06
Identities = 96/441 (21%), Positives = 173/441 (39%), Gaps = 70/441 (15%)
Query: 3151 HTIYLLPTVVICNLLPCELDFYVKGMPINGTLKPGKEA-ALHTADTSQNIELGVSLENFP 3209
+ I+L P++ + NLLP L + ++G L G A LH+ + + +EL
Sbjct: 2662 YIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTADVLHSRISGEIMEL-------- 2713
Query: 3210 LCKELLIPPGTQNYMVRMRLYDV------------NRRQLNLTIRIVCRAEGSLKIF-IS 3256
+L+ +N+ R+ D + + + + R GS + +
Sbjct: 2714 ----VLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRIGSRMVLSVF 2769
Query: 3257 APYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKE--QPNLCTMRIG 3314
+PYWLINKT L +R ++ F + +LF + K N ++I
Sbjct: 2770 SPYWLINKTTRVLQYRSEDIHVKHPADFRD--------IILFSFKKKNIFTKNKVQLKIS 2821
Query: 3315 RGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIF 3374
W FSLD +K + Y +G+ +K + + +V
Sbjct: 2822 TS-------AWSSSFSLDTVGSYGCVKCPAN----NMEYLVGVSIK--MSSFNLSRIVTL 2868
Query: 3375 APRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLM 3434
P + NKSS +L + + G N YI++ S + WP + LCVR
Sbjct: 2869 TPFCTIANKSSLELEVGEIA-SDGSMPTNKWNYIAS---SECLPFWPES-LSGKLCVR-- 2921
Query: 3435 DVPNCIWSGG--FEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPF 3492
V C S F ++N +++ D G + V++ + I+FSD + P
Sbjct: 2922 -VVGCEGSSKPFFYNRQDNGTLLSLEDLNGG---ILVDVNTAEHSTVITFSDYHEGSAPA 2977
Query: 3493 RIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEPTLPPFITLT-VKGAGSSEI- 3549
I N + ++ + Q G E + + P + +AW +PT +T T G ++
Sbjct: 2978 LIMNHTPWDILTYKQSGSPEEMV---LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLL 3034
Query: 3550 --NCNMNDFQDNRQLYYENFI 3568
C + N Q+++ +F+
Sbjct: 3035 KDGCGQFPYDANIQIHWVSFL 3055
Score = 52.0 bits (123), Expect = 1e-05
Identities = 122/611 (19%), Positives = 236/611 (38%), Gaps = 138/611 (22%)
Query: 848 VVEKFNVHLQLERRLIYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFALLTTPEMK 907
++ N+ + R L + K P + G+L + + +N++ ++ L F +LT E
Sbjct: 1317 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLL---FRILT--ENL 1371
Query: 908 TSDTQIKEKIFPQEEQRG--------SLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEF 959
T+ +K+ P+ ++ G S+ V + ++ + R V + + LL E
Sbjct: 1372 CEGTEDLDKVKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEI 1431
Query: 960 K--VNCMQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLTVHGLLLVDTMQTYGADFD 1017
K V + E GR + L V + YD +T L +MQ + DF
Sbjct: 1432 KEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYD----MTAKAYLKKISMQCF--DFT 1485
Query: 1018 LLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLTDGATLNDRSATSVSLDKILTKEQE 1077
DS+ + P+ N +++TD E
Sbjct: 1486 -------------------DSKGE-PLHIINSSNVTD----------------------E 1503
Query: 1078 SLIKLEYQFVSSECPSMNL--DSTLQVISLQVNNLDIILNPETIVELIGFLQKSFPKEKD 1135
L+K+ S+ P DST Q + + +LD++L+ E ++ + FL + P +
Sbjct: 1504 PLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPFSEP 1563
Query: 1136 DLSPQ-----PLMTDFERSFREQGTYQSTYEQNT---EVAVEIHRLNLLLLRTVGMANRE 1187
S + PL+ + RS + + +++ ++ E++ N+ +
Sbjct: 1564 SSSEKESELKPLVGE-SRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVC--------- 1613
Query: 1188 KYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYEN 1246
IA I G ++S+ D+ L + +M++ ++ + V +G+ V
Sbjct: 1614 DQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEV---- 1669
Query: 1247 IISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLS 1306
F DA EA + + SK + L+ K+ + + KF +S
Sbjct: 1670 -------FRFQLTLYPDATEGEA----YADMSKVDGKLSFKVGCIQIVYVHKFF----MS 1714
Query: 1307 MDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREPFILEENEIYGFDLA 1366
+ NF+ ++ +T TV A + A S DLA
Sbjct: 1715 LLNFLNNFQTAKEALST--ATVQAAERAASSMK------------------------DLA 1748
Query: 1367 SSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQN-FVAGDDESRS-----D 1420
+ +L+++IN+++PV+ IP+ SP ++ LG I ++N F E S D
Sbjct: 1749 QK---SFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSLPPVID 1805
Query: 1421 RLQVEIKDIKL 1431
++ +E+ +KL
Sbjct: 1806 KMNIELTQLKL 1816
Score = 39.7 bits (91), Expect = 0.066
Identities = 86/375 (22%), Positives = 148/375 (39%), Gaps = 50/375 (13%)
Query: 2201 LTEPCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIE 2260
L P L+ V RNL H VP + I G+L S++ SL+ L+ +L NL E E
Sbjct: 1317 LLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTE 1376
Query: 2261 EF--MRPY-----DLQDPRIHTVLSGEVYTCMCFL---------IDMVNVSLELKDPKRK 2304
+ ++P ++++P + +S +V+ L +D++N+ L + K
Sbjct: 1377 DLDKVKPRVQETGEIKEP-LEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNF---EIK 1432
Query: 2305 EGAGSLARFDFKKCKLLYE------------SFSNQTKSINLVSHSMMAFDTRYAGQKTS 2352
E +L + KK + L+E + T L SM FD + K
Sbjct: 1433 EVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFD--FTDSKGE 1490
Query: 2353 P-GMTNVFSCIFQPAKNSSTTQGSIQIELHFRSTKDSS--CFTVVLNNLRVFLIFDWLLL 2409
P + N + +P T+ F++ DS+ V +L + L + LL
Sbjct: 1491 PLHIINSSNVTDEPLLKMLLTKADSD-GPEFKTIHDSTKQRLKVSFASLDLVLHLEALLS 1549
Query: 2410 VHDFLHTPSDIKKQNHVTPSRHRNSSSESAIVPKTVKS-GVVTKRSSLPVSNERHLEVKV 2468
DFL + + S +S ES + P +S + K S +S + ++K+
Sbjct: 1550 FMDFLSSAAPF--------SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKI 1601
Query: 2469 NVTGTEF-VVIEDVSCFDTNAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHD 2527
F V + D C + I ++ KP+ D L I V + L + H
Sbjct: 1602 TAELNAFNVFVCDQKCNIADIKIHGMDASISVKPKQTD--VFARLKDIIVMNVDLQSIHK 1659
Query: 2528 TALSIVDPVQIQMEL 2542
A+SI+ + +L
Sbjct: 1660 KAVSILGDEVFRFQL 1674
>gi|15619008 vacuolar protein sorting 13A isoform B [Homo sapiens]
Length = 3095
Score = 212 bits (540), Expect = 6e-54
Identities = 205/933 (21%), Positives = 401/933 (42%), Gaps = 160/933 (17%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
+ E +V VLN +LG YV +L+T QLS+ + KGAV L+NL +K++AL +L++PF+VK G
Sbjct: 2 VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGH 61
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
IG + L IP+ + P + ++L+ P ++ KE+ E K+ L+ +EE
Sbjct: 62 IGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEA 121
Query: 121 WKN--DRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKN 178
+ D++Q + +VT+I++N+++KI +H+R+ED +TN P +FGI ++N
Sbjct: 122 KQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQN 181
Query: 179 VSMQN-------AVNEPVQKLMRKKQLDVAEFSIYWDVDCTL--LGDLPQM--ELQEAMA 227
+SMQ +++ +KL+R K + + YW+V + L D +L+ +
Sbjct: 182 LSMQTTDQYWVPCLHDETEKLVR-KLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
Query: 228 -RSMESRSHHYVLEPVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQI 286
++ + +V P+ A+A L N ++ +P+I+ +I+L I ++ ++ QY I
Sbjct: 241 NENIVPEGYDFVFRPISANAKLVMN--RRSDFDFSAPKINLEIELHNIAIEFNKPQYFSI 298
Query: 287 MEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHR 345
ME L+ ++ + + +R++KP V + + REWW +A++ L + + +W +
Sbjct: 299 MELLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKH 358
Query: 346 ARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHK--QEELA 403
+ Y + Y KL + + +E+ + I R+ K +
Sbjct: 359 RQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYK 418
Query: 404 ESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPE------GNVVEGL 457
E +++P+ D+ G WF W Q T E +E +
Sbjct: 419 EGVKDPE-DNKG--------------------WFSWLWSWSEQNTNEQQPDVQPETLEEM 457
Query: 458 SAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGT 517
+++ + E I +E DPT + T+ K + L+ ++ L Q
Sbjct: 458 LTPEEKALLYEAIGYSETAVDPT----LLKTFEA-----LKFFVHLKSMSIVLRENHQ-K 507
Query: 518 PQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQK 577
P++ V ++ E S+L+ R G ++ T+ F + P+ +
Sbjct: 508 PEL------------VDIVIEEF----STLIVQRPGAQAIK-FETKIDSFHITGLPDNSE 550
Query: 578 EVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIY 637
+ +S + D +F++ +E NP +R + PL IIY
Sbjct: 551 KPRLLS-----------------SLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIY 593
Query: 638 NPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIR-QTLDRLL 696
+ + + + +FF K E+ +A+ KL+ E R +T LL
Sbjct: 594 DARTVNSIVEFFRPPK------------EVHLAQLTAATLTKLE-----EFRSKTATGLL 636
Query: 697 VGDFIEESKRWTVRLDISAPQVIFPDDFKFK-NPVLVVVDLGRMLLTNTQDNSRRKSRDG 755
IE K +++++ A +I P D F L+++DLG + +T+ + + G
Sbjct: 637 Y--IIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQG 694
Query: 756 SASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYE 815
A+ + + + Y+
Sbjct: 695 EANLKE-----------------------------------------------IMDRAYD 707
Query: 816 RYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVL 875
+ + +Q++ RV DNW+ + + V H++ + +L+L + +++ D + P +
Sbjct: 708 SFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVF-MDVRMPKFKI 766
Query: 876 SGNLPDLKIHINEDKISALKNCFALLTTPEMKT 908
G LP + + I++ K+ + + PE T
Sbjct: 767 YGKLPLISLRISDKKLQGIMELIESIPKPEPVT 799
Score = 127 bits (320), Expect = 2e-28
Identities = 108/445 (24%), Positives = 194/445 (43%), Gaps = 47/445 (10%)
Query: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887
L + V Y A + I +Q+ NQ+ G PF+ Y V P + P V
Sbjct: 2627 LPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDV 2686
Query: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQA--ESEVEKYDENLH 3945
+ V + + + K+ + Q ++++ + L + +EVE + +++
Sbjct: 2687 SIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIE 2746
Query: 3946 E-----KTA---EQGGTPIRYYFE------NLKISIP----QIKLSVFTSNKLPL-DLKA 3986
KTA +Q + YF +L +S+ + K S +P+ L
Sbjct: 2747 AFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNL 2806
Query: 3987 LKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFL 4046
L ++G L +D V L F + + T + +++++H+ ++ + Q ++ +D L
Sbjct: 2807 LLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVL 2866
Query: 4047 GNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFAG 4089
GNP GL+ + SEGV G + G L+ G++ +A+K G
Sbjct: 2867 GNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITG 2926
Query: 4090 TLSDGLGK-TMDNRHQSER-EYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGV 4147
++ G+ TMD +Q +R E + A E + G GL G + G+T ++T ++G
Sbjct: 2927 AMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGA 2986
Query: 4148 KTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRC 4207
+ +GG +GF G+GKGLVG V +P G +D AS T Q ++ S + + +R PR
Sbjct: 2987 Q-KGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS----EVESLRPPR- 3040
Query: 4208 CTGPQGLLPRYSESQAEGQEQLFKL 4232
G++ Y G + L K+
Sbjct: 3041 FFNEDGVIRPYRLRDGTGNQMLQKI 3065
Score = 75.1 bits (183), Expect = 1e-12
Identities = 74/311 (23%), Positives = 142/311 (45%), Gaps = 60/311 (19%)
Query: 1782 DSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADN 1841
+ L+ + +K P+ S+YN V + I V+F+ LD+ + + + +++
Sbjct: 959 EDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINY--------- 1009
Query: 1842 HAMRLPPEGILHNV------KLEPHASMESGLQDPVNTKLDLKVHSLSLVLN-KTTSELA 1894
LHN+ K P ++ E+ + V KL LK+ + ++ + +EL+
Sbjct: 1010 ----------LHNILPQSEEKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELS 1059
Query: 1895 ---------KANVSKLVAHLEMIEGDLALQGSIGSLSL---------SDLTCHGEFYRER 1936
K N+S++ +E ++ ++ ++ S ++ SD+T Y++
Sbjct: 1060 CLQIFIQDQKCNISEI--KIEGLDSEMIMRPSETEINAKLRNIIVLDSDITA---IYKKA 1114
Query: 1937 FTTSGEEALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFI 1990
+G+E F+ Y D + DI+V+L + ++ V +F ++AFI
Sbjct: 1115 VYITGKEVFSFKMVSY--MDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFI 1172
Query: 1991 QHFTQLQDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVA 2047
+F + L Q A + V++ AQR SR+ LDI APV++IP+S S N+ VA
Sbjct: 1173 DNFQAAKQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVA 1232
Query: 2048 NLGKLKVKNKF 2058
+ G + + N F
Sbjct: 1233 DFGLITMTNTF 1243
Score = 71.6 bits (174), Expect = 2e-11
Identities = 111/531 (20%), Positives = 223/531 (41%), Gaps = 72/531 (13%)
Query: 3012 TMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSW 3071
T+EGS K +T+RS + +RN P+ S + +L P + F +PL
Sbjct: 1983 TVEGS--KKVTIRSPVQIRNHFSVPL-------SVYEGDTLLGTASPENEFNIPLGSYRS 2033
Query: 3072 RLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPD 3131
+ +P+ C+ I + ++K + + K++C S + K F + +K+N
Sbjct: 2034 FIFLKPEDENYQMCEG-IDFEEIIKN-DGALLKKKCRSKNPSKESFL-INIVPEKDNLTS 2090
Query: 3132 YMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING-TLKPGKEAAL 3190
+++S+ + + ++L P +++ NLLP ++ +Y++G+ + TL G A +
Sbjct: 2091 L---SVYSEDGWDL----PYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQI 2143
Query: 3191 HTADTSQ---NIELGVSLENFPLCKELLIPPGTQN--YMVRMRLYDVNRRQLNLTIRIVC 3245
TA + +++L + N E I P Q+ ++ + ++ + L++ + +
Sbjct: 2144 CTAQLGKARLHLKL-LDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTY 2202
Query: 3246 RAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKEQ 3305
G + +PYW++NKTG L ++ D +++ L S P F +K Q
Sbjct: 2203 NT-GQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLF-SFQPNHFFNNNKVQ 2260
Query: 3306 PNLCTMRIGRGIHPEGMPGWCQGFSLD--GGSGVRALKVIQQGNRPGLIYNIGIDVKKGR 3363
+ + FS+D G G K ++ + Y +G+ +
Sbjct: 2261 LMVTDSELS------------NQFSIDTVGSHGAVKCKGLK------MDYQVGVTI--DL 2300
Query: 3364 GRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRN 3423
+ T +V F P Y++ NKS + ++ A+ + ++S L + WP
Sbjct: 2301 SSFNITRIVTFTPFYMIKNKSKYHISVAEE---------GNDKWLS-LDLEQCIPFWPEY 2350
Query: 3424 DYDQLL--CVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRIS 3481
+LL R D P I+ + N + + + LG + E+ L + I+
Sbjct: 2351 ASSKLLIQVERSEDPPKRIYFN----KQENCILLRLDNELGG---IIAEVNLAEHSTVIT 2403
Query: 3482 FSDTDQLPPPFRIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEP 3531
F D F + N +K +V + Q ++E + + P ++ Y W +P
Sbjct: 2404 FLDYHDGAATFLLINHTKNELVQYNQSSLSE--IEDSLPPGKAVFYTWADP 2452
Score = 47.0 bits (110), Expect = 4e-04
Identities = 76/386 (19%), Positives = 143/386 (37%), Gaps = 70/386 (18%)
Query: 1060 DRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTLQVISLQVNNLDIILNPE 1117
D + V L L E L+ LEY P + ++ LQ+I + ++LDI L+ E
Sbjct: 942 DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001
Query: 1118 TIVELIGFLQKSFPKEKDDLSPQPLMTDFERS--FREQGTYQSTYEQ--NTEVAVEIHRL 1173
++ I +L P+ ++ +P ++ ++ ST E ++ E+ L
Sbjct: 1002 ALLNTINYLHNILPQSEEKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELSCL 1061
Query: 1174 NLLLLRTVGMANREKYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKN 1232
+ + + I+ I G + M S ++N L + ++D +
Sbjct: 1062 QIFI---------QDQKCNISEIKIEGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYK 1112
Query: 1233 QYVVSIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLH 1292
+ V G V F V DA A + + + + +NL + +
Sbjct: 1113 KAVYITGKEV-----------FSFKMVSYMDATAGSA----YTDMNVVDIQVNLIVGCIE 1157
Query: 1293 YNHSAKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREP 1352
KFL + +D + + L A + + AT E ++ S
Sbjct: 1158 VVFVTKFLYSILAFIDNFQAA-KQALAEATVQAAGMAATGVKELAQRSS----------- 1205
Query: 1353 FILEENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVA 1412
++ L+INI++PVV IP+ P S + V G I + N
Sbjct: 1206 ---------------------RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFH 1244
Query: 1413 GDDESRS------DRLQVEIKDIKLY 1432
ES+S D + +++ +++LY
Sbjct: 1245 MITESQSSPPPVIDLITIKLSEMRLY 1270
Score = 39.7 bits (91), Expect = 0.066
Identities = 30/138 (21%), Positives = 67/138 (48%), Gaps = 11/138 (7%)
Query: 878 NLPDLKIHINEDKISALKNCFALLTT---PEMKTSDTQIKEKIFPQEEQRGSLQDSVMNL 934
N+PDLK N + + +K F+ L E + I PQ E++ + +
Sbjct: 972 NVPDLKSTYN-NVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEKSAPVSTTETE 1030
Query: 935 TQSIVL----LEQHTREVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTNAHFVKR 990
+ V+ L+ T E ++ Q+L +++C+Q+ ++ IS +K+ G ++ + R
Sbjct: 1031 DKGDVIKKLALKLSTNEDIITLQILA---ELSCLQIFIQDQKCNISEIKIEGLDSEMIMR 1087
Query: 991 PYDAEVSLTVHGLLLVDT 1008
P + E++ + ++++D+
Sbjct: 1088 PSETEINAKLRNIIVLDS 1105
>gi|66346676 vacuolar protein sorting 13A isoform D [Homo sapiens]
Length = 3069
Score = 212 bits (540), Expect = 6e-54
Identities = 205/933 (21%), Positives = 401/933 (42%), Gaps = 160/933 (17%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
+ E +V VLN +LG YV +L+T QLS+ + KGAV L+NL +K++AL +L++PF+VK G
Sbjct: 2 VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGH 61
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
IG + L IP+ + P + ++L+ P ++ KE+ E K+ L+ +EE
Sbjct: 62 IGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEA 121
Query: 121 WKN--DRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKN 178
+ D++Q + +VT+I++N+++KI +H+R+ED +TN P +FGI ++N
Sbjct: 122 KQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQN 181
Query: 179 VSMQN-------AVNEPVQKLMRKKQLDVAEFSIYWDVDCTL--LGDLPQM--ELQEAMA 227
+SMQ +++ +KL+R K + + YW+V + L D +L+ +
Sbjct: 182 LSMQTTDQYWVPCLHDETEKLVR-KLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
Query: 228 -RSMESRSHHYVLEPVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQI 286
++ + +V P+ A+A L N ++ +P+I+ +I+L I ++ ++ QY I
Sbjct: 241 NENIVPEGYDFVFRPISANAKLVMN--RRSDFDFSAPKINLEIELHNIAIEFNKPQYFSI 298
Query: 287 MEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHR 345
ME L+ ++ + + +R++KP V + + REWW +A++ L + + +W +
Sbjct: 299 MELLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKH 358
Query: 346 ARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHK--QEELA 403
+ Y + Y KL + + +E+ + I R+ K +
Sbjct: 359 RQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYK 418
Query: 404 ESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPE------GNVVEGL 457
E +++P+ D+ G WF W Q T E +E +
Sbjct: 419 EGVKDPE-DNKG--------------------WFSWLWSWSEQNTNEQQPDVQPETLEEM 457
Query: 458 SAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGT 517
+++ + E I +E DPT + T+ K + L+ ++ L Q
Sbjct: 458 LTPEEKALLYEAIGYSETAVDPT----LLKTFEA-----LKFFVHLKSMSIVLRENHQ-K 507
Query: 518 PQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQK 577
P++ V ++ E S+L+ R G ++ T+ F + P+ +
Sbjct: 508 PEL------------VDIVIEEF----STLIVQRPGAQAIK-FETKIDSFHITGLPDNSE 550
Query: 578 EVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIY 637
+ +S + D +F++ +E NP +R + PL IIY
Sbjct: 551 KPRLLS-----------------SLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIY 593
Query: 638 NPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIR-QTLDRLL 696
+ + + + +FF K E+ +A+ KL+ E R +T LL
Sbjct: 594 DARTVNSIVEFFRPPK------------EVHLAQLTAATLTKLE-----EFRSKTATGLL 636
Query: 697 VGDFIEESKRWTVRLDISAPQVIFPDDFKFK-NPVLVVVDLGRMLLTNTQDNSRRKSRDG 755
IE K +++++ A +I P D F L+++DLG + +T+ + + G
Sbjct: 637 Y--IIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQG 694
Query: 756 SASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYE 815
A+ + + + Y+
Sbjct: 695 EANLKE-----------------------------------------------IMDRAYD 707
Query: 816 RYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVL 875
+ + +Q++ RV DNW+ + + V H++ + +L+L + +++ D + P +
Sbjct: 708 SFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVF-MDVRMPKFKI 766
Query: 876 SGNLPDLKIHINEDKISALKNCFALLTTPEMKT 908
G LP + + I++ K+ + + PE T
Sbjct: 767 YGKLPLISLRISDKKLQGIMELIESIPKPEPVT 799
Score = 126 bits (316), Expect = 5e-28
Identities = 107/442 (24%), Positives = 192/442 (43%), Gaps = 47/442 (10%)
Query: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887
L + V Y A + I +Q+ NQ+ G PF+ Y V P + P V
Sbjct: 2627 LPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDV 2686
Query: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQA--ESEVEKYDENLH 3945
+ V + + + K+ + Q ++++ + L + +EVE + +++
Sbjct: 2687 SIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIE 2746
Query: 3946 E-----KTA---EQGGTPIRYYFE------NLKISIP----QIKLSVFTSNKLPL-DLKA 3986
KTA +Q + YF +L +S+ + K S +P+ L
Sbjct: 2747 AFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNL 2806
Query: 3987 LKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFL 4046
L ++G L +D V L F + + T + +++++H+ ++ + Q ++ +D L
Sbjct: 2807 LLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVL 2866
Query: 4047 GNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFAG 4089
GNP GL+ + SEGV G + G L+ G++ +A+K G
Sbjct: 2867 GNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITG 2926
Query: 4090 TLSDGLGK-TMDNRHQSER-EYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGV 4147
++ G+ TMD +Q +R E + A E + G GL G + G+T ++T ++G
Sbjct: 2927 AMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGA 2986
Query: 4148 KTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRC 4207
+ +GG +GF G+GKGLVG V +P G +D AS T Q ++ S + + +R PR
Sbjct: 2987 Q-KGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS----EVESLRPPR- 3040
Query: 4208 CTGPQGLLPRYSESQAEGQEQL 4229
G++ Y G + L
Sbjct: 3041 FFNEDGVIRPYRLRDGTGNQML 3062
Score = 75.1 bits (183), Expect = 1e-12
Identities = 74/311 (23%), Positives = 142/311 (45%), Gaps = 60/311 (19%)
Query: 1782 DSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADN 1841
+ L+ + +K P+ S+YN V + I V+F+ LD+ + + + +++
Sbjct: 959 EDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINY--------- 1009
Query: 1842 HAMRLPPEGILHNV------KLEPHASMESGLQDPVNTKLDLKVHSLSLVLN-KTTSELA 1894
LHN+ K P ++ E+ + V KL LK+ + ++ + +EL+
Sbjct: 1010 ----------LHNILPQSEEKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELS 1059
Query: 1895 ---------KANVSKLVAHLEMIEGDLALQGSIGSLSL---------SDLTCHGEFYRER 1936
K N+S++ +E ++ ++ ++ S ++ SD+T Y++
Sbjct: 1060 CLQIFIQDQKCNISEI--KIEGLDSEMIMRPSETEINAKLRNIIVLDSDITA---IYKKA 1114
Query: 1937 FTTSGEEALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFI 1990
+G+E F+ Y D + DI+V+L + ++ V +F ++AFI
Sbjct: 1115 VYITGKEVFSFKMVSY--MDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFI 1172
Query: 1991 QHFTQLQDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVA 2047
+F + L Q A + V++ AQR SR+ LDI APV++IP+S S N+ VA
Sbjct: 1173 DNFQAAKQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVA 1232
Query: 2048 NLGKLKVKNKF 2058
+ G + + N F
Sbjct: 1233 DFGLITMTNTF 1243
Score = 71.6 bits (174), Expect = 2e-11
Identities = 111/531 (20%), Positives = 223/531 (41%), Gaps = 72/531 (13%)
Query: 3012 TMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSW 3071
T+EGS K +T+RS + +RN P+ S + +L P + F +PL
Sbjct: 1983 TVEGS--KKVTIRSPVQIRNHFSVPL-------SVYEGDTLLGTASPENEFNIPLGSYRS 2033
Query: 3072 RLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPD 3131
+ +P+ C+ I + ++K + + K++C S + K F + +K+N
Sbjct: 2034 FIFLKPEDENYQMCEG-IDFEEIIKN-DGALLKKKCRSKNPSKESFL-INIVPEKDNLTS 2090
Query: 3132 YMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING-TLKPGKEAAL 3190
+++S+ + + ++L P +++ NLLP ++ +Y++G+ + TL G A +
Sbjct: 2091 L---SVYSEDGWDL----PYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQI 2143
Query: 3191 HTADTSQ---NIELGVSLENFPLCKELLIPPGTQN--YMVRMRLYDVNRRQLNLTIRIVC 3245
TA + +++L + N E I P Q+ ++ + ++ + L++ + +
Sbjct: 2144 CTAQLGKARLHLKL-LDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTY 2202
Query: 3246 RAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKEQ 3305
G + +PYW++NKTG L ++ D +++ L S P F +K Q
Sbjct: 2203 NT-GQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLF-SFQPNHFFNNNKVQ 2260
Query: 3306 PNLCTMRIGRGIHPEGMPGWCQGFSLD--GGSGVRALKVIQQGNRPGLIYNIGIDVKKGR 3363
+ + FS+D G G K ++ + Y +G+ +
Sbjct: 2261 LMVTDSELS------------NQFSIDTVGSHGAVKCKGLK------MDYQVGVTI--DL 2300
Query: 3364 GRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRN 3423
+ T +V F P Y++ NKS + ++ A+ + ++S L + WP
Sbjct: 2301 SSFNITRIVTFTPFYMIKNKSKYHISVAEE---------GNDKWLS-LDLEQCIPFWPEY 2350
Query: 3424 DYDQLL--CVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRIS 3481
+LL R D P I+ + N + + + LG + E+ L + I+
Sbjct: 2351 ASSKLLIQVERSEDPPKRIYFN----KQENCILLRLDNELGG---IIAEVNLAEHSTVIT 2403
Query: 3482 FSDTDQLPPPFRIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEP 3531
F D F + N +K +V + Q ++E + + P ++ Y W +P
Sbjct: 2404 FLDYHDGAATFLLINHTKNELVQYNQSSLSE--IEDSLPPGKAVFYTWADP 2452
Score = 47.0 bits (110), Expect = 4e-04
Identities = 76/386 (19%), Positives = 143/386 (37%), Gaps = 70/386 (18%)
Query: 1060 DRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTLQVISLQVNNLDIILNPE 1117
D + V L L E L+ LEY P + ++ LQ+I + ++LDI L+ E
Sbjct: 942 DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001
Query: 1118 TIVELIGFLQKSFPKEKDDLSPQPLMTDFERS--FREQGTYQSTYEQ--NTEVAVEIHRL 1173
++ I +L P+ ++ +P ++ ++ ST E ++ E+ L
Sbjct: 1002 ALLNTINYLHNILPQSEEKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELSCL 1061
Query: 1174 NLLLLRTVGMANREKYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKN 1232
+ + + I+ I G + M S ++N L + ++D +
Sbjct: 1062 QIFI---------QDQKCNISEIKIEGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYK 1112
Query: 1233 QYVVSIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLH 1292
+ V G V F V DA A + + + + +NL + +
Sbjct: 1113 KAVYITGKEV-----------FSFKMVSYMDATAGSA----YTDMNVVDIQVNLIVGCIE 1157
Query: 1293 YNHSAKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREP 1352
KFL + +D + + L A + + AT E ++ S
Sbjct: 1158 VVFVTKFLYSILAFIDNFQAA-KQALAEATVQAAGMAATGVKELAQRSS----------- 1205
Query: 1353 FILEENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVA 1412
++ L+INI++PVV IP+ P S + V G I + N
Sbjct: 1206 ---------------------RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFH 1244
Query: 1413 GDDESRS------DRLQVEIKDIKLY 1432
ES+S D + +++ +++LY
Sbjct: 1245 MITESQSSPPPVIDLITIKLSEMRLY 1270
Score = 39.7 bits (91), Expect = 0.066
Identities = 30/138 (21%), Positives = 67/138 (48%), Gaps = 11/138 (7%)
Query: 878 NLPDLKIHINEDKISALKNCFALLTT---PEMKTSDTQIKEKIFPQEEQRGSLQDSVMNL 934
N+PDLK N + + +K F+ L E + I PQ E++ + +
Sbjct: 972 NVPDLKSTYN-NVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEKSAPVSTTETE 1030
Query: 935 TQSIVL----LEQHTREVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTNAHFVKR 990
+ V+ L+ T E ++ Q+L +++C+Q+ ++ IS +K+ G ++ + R
Sbjct: 1031 DKGDVIKKLALKLSTNEDIITLQILA---ELSCLQIFIQDQKCNISEIKIEGLDSEMIMR 1087
Query: 991 PYDAEVSLTVHGLLLVDT 1008
P + E++ + ++++D+
Sbjct: 1088 PSETEINAKLRNIIVLDS 1105
>gi|66346674 vacuolar protein sorting 13A isoform A [Homo sapiens]
Length = 3174
Score = 212 bits (540), Expect = 6e-54
Identities = 205/933 (21%), Positives = 401/933 (42%), Gaps = 160/933 (17%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
+ E +V VLN +LG YV +L+T QLS+ + KGAV L+NL +K++AL +L++PF+VK G
Sbjct: 2 VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGH 61
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
IG + L IP+ + P + ++L+ P ++ KE+ E K+ L+ +EE
Sbjct: 62 IGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEA 121
Query: 121 WKN--DRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKN 178
+ D++Q + +VT+I++N+++KI +H+R+ED +TN P +FGI ++N
Sbjct: 122 KQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQN 181
Query: 179 VSMQN-------AVNEPVQKLMRKKQLDVAEFSIYWDVDCTL--LGDLPQM--ELQEAMA 227
+SMQ +++ +KL+R K + + YW+V + L D +L+ +
Sbjct: 182 LSMQTTDQYWVPCLHDETEKLVR-KLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
Query: 228 -RSMESRSHHYVLEPVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQI 286
++ + +V P+ A+A L N ++ +P+I+ +I+L I ++ ++ QY I
Sbjct: 241 NENIVPEGYDFVFRPISANAKLVMN--RRSDFDFSAPKINLEIELHNIAIEFNKPQYFSI 298
Query: 287 MEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHR 345
ME L+ ++ + + +R++KP V + + REWW +A++ L + + +W +
Sbjct: 299 MELLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKH 358
Query: 346 ARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHK--QEELA 403
+ Y + Y KL + + +E+ + I R+ K +
Sbjct: 359 RQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYK 418
Query: 404 ESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPE------GNVVEGL 457
E +++P+ D+ G WF W Q T E +E +
Sbjct: 419 EGVKDPE-DNKG--------------------WFSWLWSWSEQNTNEQQPDVQPETLEEM 457
Query: 458 SAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGT 517
+++ + E I +E DPT + T+ K + L+ ++ L Q
Sbjct: 458 LTPEEKALLYEAIGYSETAVDPT----LLKTFEA-----LKFFVHLKSMSIVLRENHQ-K 507
Query: 518 PQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQK 577
P++ V ++ E S+L+ R G ++ T+ F + P+ +
Sbjct: 508 PEL------------VDIVIEEF----STLIVQRPGAQAIK-FETKIDSFHITGLPDNSE 550
Query: 578 EVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIY 637
+ +S + D +F++ +E NP +R + PL IIY
Sbjct: 551 KPRLLS-----------------SLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIY 593
Query: 638 NPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIR-QTLDRLL 696
+ + + + +FF K E+ +A+ KL+ E R +T LL
Sbjct: 594 DARTVNSIVEFFRPPK------------EVHLAQLTAATLTKLE-----EFRSKTATGLL 636
Query: 697 VGDFIEESKRWTVRLDISAPQVIFPDDFKFK-NPVLVVVDLGRMLLTNTQDNSRRKSRDG 755
IE K +++++ A +I P D F L+++DLG + +T+ + + G
Sbjct: 637 Y--IIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQG 694
Query: 756 SASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYE 815
A+ + + + Y+
Sbjct: 695 EANLKE-----------------------------------------------IMDRAYD 707
Query: 816 RYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVL 875
+ + +Q++ RV DNW+ + + V H++ + +L+L + +++ D + P +
Sbjct: 708 SFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVF-MDVRMPKFKI 766
Query: 876 SGNLPDLKIHINEDKISALKNCFALLTTPEMKT 908
G LP + + I++ K+ + + PE T
Sbjct: 767 YGKLPLISLRISDKKLQGIMELIESIPKPEPVT 799
Score = 128 bits (322), Expect = 1e-28
Identities = 114/483 (23%), Positives = 212/483 (43%), Gaps = 51/483 (10%)
Query: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887
L + V Y A + I +Q+ NQ+ G PF+ Y V P + P V
Sbjct: 2627 LPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDV 2686
Query: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQA--ESEVEKYDENLH 3945
+ V + + + K+ + Q ++++ + L + +EVE + +++
Sbjct: 2687 SIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIE 2746
Query: 3946 E-----KTA---EQGGTPIRYYFE------NLKISIP----QIKLSVFTSNKLPL-DLKA 3986
KTA +Q + YF +L +S+ + K S +P+ L
Sbjct: 2747 AFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNL 2806
Query: 3987 LKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFL 4046
L ++G L +D V L F + + T + +++++H+ ++ + Q ++ +D L
Sbjct: 2807 LLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVL 2866
Query: 4047 GNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFAG 4089
GNP GL+ + SEGV G + G L+ G++ +A+K G
Sbjct: 2867 GNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITG 2926
Query: 4090 TLSDGLGK-TMDNRHQSER-EYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGV 4147
++ G+ TMD +Q +R E + A E + G GL G + G+T ++T ++G
Sbjct: 2927 AMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGA 2986
Query: 4148 KTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRC 4207
+ +GG +GF G+GKGLVG V +P G +D AS T Q ++ S + + +R PR
Sbjct: 2987 Q-KGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS----EVESLRPPR- 3040
Query: 4208 CTGPQGLLPRYSESQAEGQEQLFKLTDN---IQDEFFIAVENIDSYCVLISSKAVYFLKS 4264
G++ Y G Q+ ++ +N + ++F V + ++I+ + V F+
Sbjct: 3041 FFNEDGVIRPYRLRDGTG-NQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTK 3099
Query: 4265 GDY 4267
G +
Sbjct: 3100 GTF 3102
Score = 75.1 bits (183), Expect = 1e-12
Identities = 74/311 (23%), Positives = 142/311 (45%), Gaps = 60/311 (19%)
Query: 1782 DSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADN 1841
+ L+ + +K P+ S+YN V + I V+F+ LD+ + + + +++
Sbjct: 959 EDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINY--------- 1009
Query: 1842 HAMRLPPEGILHNV------KLEPHASMESGLQDPVNTKLDLKVHSLSLVLN-KTTSELA 1894
LHN+ K P ++ E+ + V KL LK+ + ++ + +EL+
Sbjct: 1010 ----------LHNILPQSEEKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELS 1059
Query: 1895 ---------KANVSKLVAHLEMIEGDLALQGSIGSLSL---------SDLTCHGEFYRER 1936
K N+S++ +E ++ ++ ++ S ++ SD+T Y++
Sbjct: 1060 CLQIFIQDQKCNISEI--KIEGLDSEMIMRPSETEINAKLRNIIVLDSDITA---IYKKA 1114
Query: 1937 FTTSGEEALIFQTFKYGRPDPLLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFI 1990
+G+E F+ Y D + DI+V+L + ++ V +F ++AFI
Sbjct: 1115 VYITGKEVFSFKMVSY--MDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFI 1172
Query: 1991 QHFTQLQDVLGR---QRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVA 2047
+F + L Q A + V++ AQR SR+ LDI APV++IP+S S N+ VA
Sbjct: 1173 DNFQAAKQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVA 1232
Query: 2048 NLGKLKVKNKF 2058
+ G + + N F
Sbjct: 1233 DFGLITMTNTF 1243
Score = 71.6 bits (174), Expect = 2e-11
Identities = 111/531 (20%), Positives = 223/531 (41%), Gaps = 72/531 (13%)
Query: 3012 TMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSW 3071
T+EGS K +T+RS + +RN P+ S + +L P + F +PL
Sbjct: 1983 TVEGS--KKVTIRSPVQIRNHFSVPL-------SVYEGDTLLGTASPENEFNIPLGSYRS 2033
Query: 3072 RLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPD 3131
+ +P+ C+ I + ++K + + K++C S + K F + +K+N
Sbjct: 2034 FIFLKPEDENYQMCEG-IDFEEIIKN-DGALLKKKCRSKNPSKESFL-INIVPEKDNLTS 2090
Query: 3132 YMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING-TLKPGKEAAL 3190
+++S+ + + ++L P +++ NLLP ++ +Y++G+ + TL G A +
Sbjct: 2091 L---SVYSEDGWDL----PYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQI 2143
Query: 3191 HTADTSQ---NIELGVSLENFPLCKELLIPPGTQN--YMVRMRLYDVNRRQLNLTIRIVC 3245
TA + +++L + N E I P Q+ ++ + ++ + L++ + +
Sbjct: 2144 CTAQLGKARLHLKL-LDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTY 2202
Query: 3246 RAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKEQ 3305
G + +PYW++NKTG L ++ D +++ L S P F +K Q
Sbjct: 2203 NT-GQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLF-SFQPNHFFNNNKVQ 2260
Query: 3306 PNLCTMRIGRGIHPEGMPGWCQGFSLD--GGSGVRALKVIQQGNRPGLIYNIGIDVKKGR 3363
+ + FS+D G G K ++ + Y +G+ +
Sbjct: 2261 LMVTDSELS------------NQFSIDTVGSHGAVKCKGLK------MDYQVGVTI--DL 2300
Query: 3364 GRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRN 3423
+ T +V F P Y++ NKS + ++ A+ + ++S L + WP
Sbjct: 2301 SSFNITRIVTFTPFYMIKNKSKYHISVAEE---------GNDKWLS-LDLEQCIPFWPEY 2350
Query: 3424 DYDQLL--CVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRIS 3481
+LL R D P I+ + N + + + LG + E+ L + I+
Sbjct: 2351 ASSKLLIQVERSEDPPKRIYFN----KQENCILLRLDNELGG---IIAEVNLAEHSTVIT 2403
Query: 3482 FSDTDQLPPPFRIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEP 3531
F D F + N +K +V + Q ++E + + P ++ Y W +P
Sbjct: 2404 FLDYHDGAATFLLINHTKNELVQYNQSSLSE--IEDSLPPGKAVFYTWADP 2452
Score = 47.0 bits (110), Expect = 4e-04
Identities = 76/386 (19%), Positives = 143/386 (37%), Gaps = 70/386 (18%)
Query: 1060 DRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMN--LDSTLQVISLQVNNLDIILNPE 1117
D + V L L E L+ LEY P + ++ LQ+I + ++LDI L+ E
Sbjct: 942 DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001
Query: 1118 TIVELIGFLQKSFPKEKDDLSPQPLMTDFERS--FREQGTYQSTYEQ--NTEVAVEIHRL 1173
++ I +L P+ ++ +P ++ ++ ST E ++ E+ L
Sbjct: 1002 ALLNTINYLHNILPQSEEKSAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELSCL 1061
Query: 1174 NLLLLRTVGMANREKYGRKIATASIGGTKVNVSMG-STFDMNGSLGCLQLMDLTQDNVKN 1232
+ + + I+ I G + M S ++N L + ++D +
Sbjct: 1062 QIFI---------QDQKCNISEIKIEGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYK 1112
Query: 1233 QYVVSIGNSVGYENIISDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLH 1292
+ V G V F V DA A + + + + +NL + +
Sbjct: 1113 KAVYITGKEV-----------FSFKMVSYMDATAGSA----YTDMNVVDIQVNLIVGCIE 1157
Query: 1293 YNHSAKFLKELTLSMDELEENFRGMLKSAATKVTTVLATKTAEYSEMVSLFETPRKTREP 1352
KFL + +D + + L A + + AT E ++ S
Sbjct: 1158 VVFVTKFLYSILAFIDNFQAA-KQALAEATVQAAGMAATGVKELAQRSS----------- 1205
Query: 1353 FILEENEIYGFDLASSHLDTVKLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVA 1412
++ L+INI++PVV IP+ P S + V G I + N
Sbjct: 1206 ---------------------RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFH 1244
Query: 1413 GDDESRS------DRLQVEIKDIKLY 1432
ES+S D + +++ +++LY
Sbjct: 1245 MITESQSSPPPVIDLITIKLSEMRLY 1270
Score = 39.7 bits (91), Expect = 0.066
Identities = 30/138 (21%), Positives = 67/138 (48%), Gaps = 11/138 (7%)
Query: 878 NLPDLKIHINEDKISALKNCFALLTT---PEMKTSDTQIKEKIFPQEEQRGSLQDSVMNL 934
N+PDLK N + + +K F+ L E + I PQ E++ + +
Sbjct: 972 NVPDLKSTYN-NVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEKSAPVSTTETE 1030
Query: 935 TQSIVL----LEQHTREVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTNAHFVKR 990
+ V+ L+ T E ++ Q+L +++C+Q+ ++ IS +K+ G ++ + R
Sbjct: 1031 DKGDVIKKLALKLSTNEDIITLQILA---ELSCLQIFIQDQKCNISEIKIEGLDSEMIMR 1087
Query: 991 PYDAEVSLTVHGLLLVDT 1008
P + E++ + ++++D+
Sbjct: 1088 PSETEINAKLRNIIVLDS 1105
>gi|66346672 vacuolar protein sorting 13A isoform C [Homo sapiens]
Length = 3135
Score = 212 bits (540), Expect = 6e-54
Identities = 205/933 (21%), Positives = 401/933 (42%), Gaps = 160/933 (17%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60
+ E +V VLN +LG YV +L+T QLS+ + KGAV L+NL +K++AL +L++PF+VK G
Sbjct: 2 VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGH 61
Query: 61 IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120
IG + L IP+ + P + ++L+ P ++ KE+ E K+ L+ +EE
Sbjct: 62 IGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEA 121
Query: 121 WKN--DRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKN 178
+ D++Q + +VT+I++N+++KI +H+R+ED +TN P +FGI ++N
Sbjct: 122 KQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQN 181
Query: 179 VSMQN-------AVNEPVQKLMRKKQLDVAEFSIYWDVDCTL--LGDLPQM--ELQEAMA 227
+SMQ +++ +KL+R K + + YW+V + L D +L+ +
Sbjct: 182 LSMQTTDQYWVPCLHDETEKLVR-KLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
Query: 228 -RSMESRSHHYVLEPVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQI 286
++ + +V P+ A+A L N ++ +P+I+ +I+L I ++ ++ QY I
Sbjct: 241 NENIVPEGYDFVFRPISANAKLVMN--RRSDFDFSAPKINLEIELHNIAIEFNKPQYFSI 298
Query: 287 MEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHR 345
ME L+ ++ + + +R++KP V + + REWW +A++ L + + +W +
Sbjct: 299 MELLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKH 358
Query: 346 ARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHK--QEELA 403
+ Y + Y KL + + +E+ + I R+ K +
Sbjct: 359 RQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYK 418
Query: 404 ESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPE------GNVVEGL 457
E +++P+ D+ G WF W Q T E +E +
Sbjct: 419 EGVKDPE-DNKG--------------------WFSWLWSWSEQNTNEQQPDVQPETLEEM 457
Query: 458 SAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGT 517
+++ + E I +E DPT + T+ K + L+ ++ L Q
Sbjct: 458 LTPEEKALLYEAIGYSETAVDPT----LLKTFEA-----LKFFVHLKSMSIVLRENHQ-K 507
Query: 518 PQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQK 577
P++ V ++ E S+L+ R G ++ T+ F + P+ +
Sbjct: 508 PEL------------VDIVIEEF----STLIVQRPGAQAIK-FETKIDSFHITGLPDNSE 550
Query: 578 EVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIY 637
+ +S + D +F++ +E NP +R + PL IIY
Sbjct: 551 KPRLLS-----------------SLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIY 593
Query: 638 NPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIR-QTLDRLL 696
+ + + + +FF K E+ +A+ KL+ E R +T LL
Sbjct: 594 DARTVNSIVEFFRPPK------------EVHLAQLTAATLTKLE-----EFRSKTATGLL 636
Query: 697 VGDFIEESKRWTVRLDISAPQVIFPDDFKFK-NPVLVVVDLGRMLLTNTQDNSRRKSRDG 755
IE K +++++ A +I P D F L+++DLG + +T+ + + G
Sbjct: 637 Y--IIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQG 694
Query: 756 SASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYE 815
A+ + + + Y+
Sbjct: 695 EANLKE-----------------------------------------------IMDRAYD 707
Query: 816 RYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVL 875
+ + +Q++ RV DNW+ + + V H++ + +L+L + +++ D + P +
Sbjct: 708 SFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVF-MDVRMPKFKI 766
Query: 876 SGNLPDLKIHINEDKISALKNCFALLTTPEMKT 908
G LP + + I++ K+ + + PE T
Sbjct: 767 YGKLPLISLRISDKKLQGIMELIESIPKPEPVT 799
Score = 128 bits (322), Expect = 1e-28
Identities = 114/483 (23%), Positives = 212/483 (43%), Gaps = 51/483 (10%)
Query: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887
L + V Y A + I +Q+ NQ+ G PF+ Y V P + P V
Sbjct: 2588 LPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDV 2647
Query: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQA--ESEVEKYDENLH 3945
+ V + + + K+ + Q ++++ + L + +EVE + +++
Sbjct: 2648 SIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIE 2707
Query: 3946 E-----KTA---EQGGTPIRYYFE------NLKISIP----QIKLSVFTSNKLPL-DLKA 3986
KTA +Q + YF +L +S+ + K S +P+ L
Sbjct: 2708 AFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNL 2767
Query: 3987 LKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFL 4046
L ++G L +D V L F + + T + +++++H+ ++ + Q ++ +D L
Sbjct: 2768 LLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVL 2827
Query: 4047 GNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFAG 4089
GNP GL+ + SEGV G + G L+ G++ +A+K G
Sbjct: 2828 GNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITG 2887
Query: 4090 TLSDGLGK-TMDNRHQSER-EYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGV 4147
++ G+ TMD +Q +R E + A E + G GL G + G+T ++T ++G
Sbjct: 2888 AMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGA 2947
Query: 4148 KTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRC 4207
+ +GG +GF G+GKGLVG V +P G +D AS T Q ++ S + + +R PR
Sbjct: 2948 Q-KGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS----EVESLRPPR- 3001
Query: 4208 CTGPQGLLPRYSESQAEGQEQLFKLTDN---IQDEFFIAVENIDSYCVLISSKAVYFLKS 4264
G++ Y G Q+ ++ +N + ++F V + ++I+ + V F+
Sbjct: 3002 FFNEDGVIRPYRLRDGTG-NQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTK 3060
Query: 4265 GDY 4267
G +
Sbjct: 3061 GTF 3063
Score = 71.6 bits (174), Expect = 2e-11
Identities = 111/531 (20%), Positives = 223/531 (41%), Gaps = 72/531 (13%)
Query: 3012 TMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSW 3071
T+EGS K +T+RS + +RN P+ S + +L P + F +PL
Sbjct: 1944 TVEGS--KKVTIRSPVQIRNHFSVPL-------SVYEGDTLLGTASPENEFNIPLGSYRS 1994
Query: 3072 RLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPD 3131
+ +P+ C+ I + ++K + + K++C S + K F + +K+N
Sbjct: 1995 FIFLKPEDENYQMCEG-IDFEEIIKN-DGALLKKKCRSKNPSKESFL-INIVPEKDNLTS 2051
Query: 3132 YMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING-TLKPGKEAAL 3190
+++S+ + + ++L P +++ NLLP ++ +Y++G+ + TL G A +
Sbjct: 2052 L---SVYSEDGWDL----PYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQI 2104
Query: 3191 HTADTSQ---NIELGVSLENFPLCKELLIPPGTQN--YMVRMRLYDVNRRQLNLTIRIVC 3245
TA + +++L + N E I P Q+ ++ + ++ + L++ + +
Sbjct: 2105 CTAQLGKARLHLKL-LDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTY 2163
Query: 3246 RAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKEQ 3305
G + +PYW++NKTG L ++ D +++ L S P F +K Q
Sbjct: 2164 NT-GQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLF-SFQPNHFFNNNKVQ 2221
Query: 3306 PNLCTMRIGRGIHPEGMPGWCQGFSLD--GGSGVRALKVIQQGNRPGLIYNIGIDVKKGR 3363
+ + FS+D G G K ++ + Y +G+ +
Sbjct: 2222 LMVTDSELS------------NQFSIDTVGSHGAVKCKGLK------MDYQVGVTI--DL 2261
Query: 3364 GRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRN 3423
+ T +V F P Y++ NKS + ++ A+ + ++S L + WP
Sbjct: 2262 SSFNITRIVTFTPFYMIKNKSKYHISVAEE---------GNDKWLS-LDLEQCIPFWPEY 2311
Query: 3424 DYDQLL--CVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRIS 3481
+LL R D P I+ + N + + + LG + E+ L + I+
Sbjct: 2312 ASSKLLIQVERSEDPPKRIYFN----KQENCILLRLDNELGG---IIAEVNLAEHSTVIT 2364
Query: 3482 FSDTDQLPPPFRIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEP 3531
F D F + N +K +V + Q ++E + + P ++ Y W +P
Sbjct: 2365 FLDYHDGAATFLLINHTKNELVQYNQSSLSE--IEDSLPPGKAVFYTWADP 2413
Score = 69.3 bits (168), Expect = 8e-11
Identities = 71/290 (24%), Positives = 127/290 (43%), Gaps = 57/290 (19%)
Query: 1782 DSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADN 1841
+ L+ + +K P+ S+YN V + I V+F+ LD+ + + + +++
Sbjct: 959 EDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINY--------- 1009
Query: 1842 HAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKL 1901
LHN+ P + +S PV+T T +E + KL
Sbjct: 1010 ----------LHNIL--PQSEEKSA---PVST---------------TETEDKGDVIKKL 1039
Query: 1902 VAHLEMI--EGDLALQGSIGSLSL--SDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDP 1957
EMI + + + ++ + SD+T Y++ +G+E F+ Y D
Sbjct: 1040 GLDSEMIMRPSETEINAKLRNIIVLDSDITA---IYKKAVYITGKEVFSFKMVSY--MDA 1094
Query: 1958 LLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIE 2008
+ DI+V+L + ++ V +F ++AFI +F + L Q A +
Sbjct: 1095 TAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMA 1154
Query: 2009 GQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058
V++ AQR SR+ LDI APV++IP+S S N+ VA+ G + + N F
Sbjct: 1155 ATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTF 1204
Score = 37.0 bits (84), Expect = 0.43
Identities = 21/65 (32%), Positives = 37/65 (56%), Gaps = 6/65 (9%)
Query: 1374 KLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRS------DRLQVEIK 1427
++ L+INI++PVV IP+ P S + V G I + N ES+S D + +++
Sbjct: 1167 RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIKLS 1226
Query: 1428 DIKLY 1432
+++LY
Sbjct: 1227 EMRLY 1231
>gi|35493713 vacuolar protein sorting 13B isoform 5 [Homo sapiens]
Length = 4022
Score = 72.8 bits (177), Expect = 7e-12
Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 27/218 (12%)
Query: 4003 INLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGVTG 4062
++ F R + T +++ + H+ L +A ++GS+D LG+P L+ + GV
Sbjct: 3614 LSFSVFERGPIFTTARQLVHALAMHYAAGALFRAGWVVGSLDILGSPASLVRSIGNGVAD 3673
Query: 4063 LIKYGNVG-----------------GLIRNVTHGVSNSAAKFAGTLSDGLGK-TMDNRHQ 4104
+ G +++++ G S A +L+ + + ++D H
Sbjct: 3674 FFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHY 3733
Query: 4105 SEREYIRYHAATS-GEHLVAGIHGLAHGIIGGLTSVITSTVEGVK--TEGGVS------G 4155
+ +E R S GE L G+ L ++G + ++ ++ + +E S G
Sbjct: 3734 NRQEEWRRQLPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKG 3793
Query: 4156 FISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLS 4193
ISG+GKG++G TKP+ GA + S+T + A LS
Sbjct: 3794 VISGVGKGIMGVFTKPIGGAAELVSQTGYGILHGAGLS 3831
Score = 64.7 bits (156), Expect = 2e-09
Identities = 47/170 (27%), Positives = 87/170 (51%), Gaps = 10/170 (5%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDAL-KELELPFEVKAG 59
MLE V +L +Y+ +Y+ NL L ++L G V L L LK D L +EL+LPF +G
Sbjct: 1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60
Query: 60 FIGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQD-FNDEKEKLLERERKKALLQALE 118
I ++ + +P+ + +P VI+I+++ I K++D D+ E ++ ++ +
Sbjct: 61 HIHELRIHVPWTKLGSEPVVITINTMECI---LKLKDGIQDDHESCGSNSTNRSTAESTK 117
Query: 119 EKWKNDRQQKG----ESYWYSVTASVVTRIVENIELKIQDVHLRF-EDGV 163
K R Q+ S++ R+V N+ + I ++ L++ ED +
Sbjct: 118 SSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDI 167
>gi|35493701 vacuolar protein sorting 13B isoform 1 [Homo sapiens]
Length = 3997
Score = 72.8 bits (177), Expect = 7e-12
Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 27/218 (12%)
Query: 4003 INLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGVTG 4062
++ F R + T +++ + H+ L +A ++GS+D LG+P L+ + GV
Sbjct: 3589 LSFSVFERGPIFTTARQLVHALAMHYAAGALFRAGWVVGSLDILGSPASLVRSIGNGVAD 3648
Query: 4063 LIKYGNVG-----------------GLIRNVTHGVSNSAAKFAGTLSDGLGK-TMDNRHQ 4104
+ G +++++ G S A +L+ + + ++D H
Sbjct: 3649 FFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHY 3708
Query: 4105 SEREYIRYHAATS-GEHLVAGIHGLAHGIIGGLTSVITSTVEGVK--TEGGVS------G 4155
+ +E R S GE L G+ L ++G + ++ ++ + +E S G
Sbjct: 3709 NRQEEWRRQLPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKG 3768
Query: 4156 FISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLS 4193
ISG+GKG++G TKP+ GA + S+T + A LS
Sbjct: 3769 VISGVGKGIMGVFTKPIGGAAELVSQTGYGILHGAGLS 3806
Score = 64.7 bits (156), Expect = 2e-09
Identities = 47/170 (27%), Positives = 87/170 (51%), Gaps = 10/170 (5%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDAL-KELELPFEVKAG 59
MLE V +L +Y+ +Y+ NL L ++L G V L L LK D L +EL+LPF +G
Sbjct: 1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60
Query: 60 FIGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQD-FNDEKEKLLERERKKALLQALE 118
I ++ + +P+ + +P VI+I+++ I K++D D+ E ++ ++ +
Sbjct: 61 HIHELRIHVPWTKLGSEPVVITINTMECI---LKLKDGIQDDHESCGSNSTNRSTAESTK 117
Query: 119 EKWKNDRQQKG----ESYWYSVTASVVTRIVENIELKIQDVHLRF-EDGV 163
K R Q+ S++ R+V N+ + I ++ L++ ED +
Sbjct: 118 SSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDI 167
>gi|119874215 vacuolar protein sorting 13B isoform 4 [Homo sapiens]
Length = 415
Score = 64.7 bits (156), Expect = 2e-09
Identities = 47/170 (27%), Positives = 87/170 (51%), Gaps = 10/170 (5%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDAL-KELELPFEVKAG 59
MLE V +L +Y+ +Y+ NL L ++L G V L L LK D L +EL+LPF +G
Sbjct: 1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60
Query: 60 FIGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQD-FNDEKEKLLERERKKALLQALE 118
I ++ + +P+ + +P VI+I+++ I K++D D+ E ++ ++ +
Sbjct: 61 HIHELRIHVPWTKLGSEPVVITINTMECI---LKLKDGIQDDHESCGSNSTNRSTAESTK 117
Query: 119 EKWKNDRQQKG----ESYWYSVTASVVTRIVENIELKIQDVHLRF-EDGV 163
K R Q+ S++ R+V N+ + I ++ L++ ED +
Sbjct: 118 SSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDI 167
>gi|35493725 vacuolar protein sorting 13B isoform 3 [Homo sapiens]
Length = 863
Score = 64.7 bits (156), Expect = 2e-09
Identities = 47/170 (27%), Positives = 87/170 (51%), Gaps = 10/170 (5%)
Query: 1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDAL-KELELPFEVKAG 59
MLE V +L +Y+ +Y+ NL L ++L G V L L LK D L +EL+LPF +G
Sbjct: 1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60
Query: 60 FIGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQD-FNDEKEKLLERERKKALLQALE 118
I ++ + +P+ + +P VI+I+++ I K++D D+ E ++ ++ +
Sbjct: 61 HIHELRIHVPWTKLGSEPVVITINTMECI---LKLKDGIQDDHESCGSNSTNRSTAESTK 117
Query: 119 EKWKNDRQQKG----ESYWYSVTASVVTRIVENIELKIQDVHLRF-EDGV 163
K R Q+ S++ R+V N+ + I ++ L++ ED +
Sbjct: 118 SSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDI 167
>gi|239047271 autophagy related 2A [Homo sapiens]
Length = 1938
Score = 50.4 bits (119), Expect = 4e-05
Identities = 29/96 (30%), Positives = 53/96 (55%), Gaps = 5/96 (5%)
Query: 3 EGLVAWVLNTYLGKYVN-NLNTDQLSVALLKGAVELENLPLK----KDALKELELPFEVK 57
E + ++L+ YLG + +L+ DQLS+ L KG+V L ++ L+ + L+ +E P E+
Sbjct: 14 ERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELV 73
Query: 58 AGFIGKVTLQIPFYRPHVDPWVISISSLHLIGAPEK 93
GF+G + + +P+ D + +S L L P +
Sbjct: 74 EGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQPRR 109
>gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens]
Length = 2078
Score = 48.9 bits (115), Expect = 1e-04
Identities = 48/217 (22%), Positives = 86/217 (39%), Gaps = 17/217 (7%)
Query: 8 WVLNTYLGKYVNN-LNTDQLSVALLKGAVELENLPLKKDALKEL----ELPFEVKAGFIG 62
++L YLG ++ L+ +QLS+ L +G L +PL K L E+ + P EV GFI
Sbjct: 16 YLLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESADAPLEVTEGFIQ 75
Query: 63 KVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKE--KLLERERKKALLQALEEK 120
++L +P+ D + + L ++ P E + + L +K
Sbjct: 76 SISLSVPWGSLLQDNCALEVRGLEMVFRPRPRPATGSEPMYWSSFMTSSMQLAKECLSQK 135
Query: 121 WKNDRQQKGESYWYSVT--ASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGI---- 174
D Q +G + + A + ++ +++ D LR E N A I
Sbjct: 136 -LTDEQGEGSQPFEGLEKFAETIETVLRRVKVTFIDTVLRIEHVPENSKTGTALEIRIER 194
Query: 175 ---CIKNVSMQNAVNEPVQKLMRKKQLDVAEFSIYWD 208
C + + +N K L ++ S++WD
Sbjct: 195 TVYCDETADESSGINVHQPTAFAHKLLQLSGVSLFWD 231
>gi|55749659 UHRF1 (ICBP90) binding protein 1-like isoform b [Homo
sapiens]
Length = 522
Score = 43.1 bits (100), Expect = 0.006
Identities = 23/87 (26%), Positives = 50/87 (57%), Gaps = 3/87 (3%)
Query: 2 LEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKE-LELP--FEVKA 58
+ G++ + +L ++ NL+ D+++++ LKG EL+NL L ++ L+ L+LP +
Sbjct: 1 MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINK 60
Query: 59 GFIGKVTLQIPFYRPHVDPWVISISSL 85
F K +++IP+ + P +S+ +
Sbjct: 61 VFCNKASIRIPWTKLKTHPICLSLDKV 87
>gi|55749644 UHRF1 (ICBP90) binding protein 1-like isoform a [Homo
sapiens]
Length = 1464
Score = 43.1 bits (100), Expect = 0.006
Identities = 23/87 (26%), Positives = 50/87 (57%), Gaps = 3/87 (3%)
Query: 2 LEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKE-LELP--FEVKA 58
+ G++ + +L ++ NL+ D+++++ LKG EL+NL L ++ L+ L+LP +
Sbjct: 1 MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINK 60
Query: 59 GFIGKVTLQIPFYRPHVDPWVISISSL 85
F K +++IP+ + P +S+ +
Sbjct: 61 VFCNKASIRIPWTKLKTHPICLSLDKV 87
>gi|239754902 PREDICTED: hypothetical protein [Homo sapiens]
Length = 274
Score = 40.4 bits (93), Expect = 0.039
Identities = 48/212 (22%), Positives = 84/212 (39%), Gaps = 20/212 (9%)
Query: 2871 TGCTLWFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEWREVLTGEEIPFEFEA 2930
TGC W T + R HS G P G G+F D + E ++++
Sbjct: 64 TGCPAWSPLKTQSEIRGCTHHSSGAG--PAGTGSFCDTCRITRLCEQTQLPELTEYQYQH 121
Query: 2931 R---GKLRHRHTH-DLRIHQLQVRVNGWEQVSPVSVDKVGTFFRYAAPDKNSSSS---TI 2983
+ GK+ + + L++H Q R + +VS K+ +P N SSS +
Sbjct: 122 QKLTGKMNNTSSSPGLQLHNPQTRTSAPPRVSSCKTLKLEHQLLPGSPANNISSSPGLQL 181
Query: 2984 GSPSSRTNIIHPQVYFSSLPPVRVVFAVTMEGSARKVITVRSALIVR-NRLETPMELRLD 3042
P +RT+ P ++ S+ + ++ ++ + T S + R L+ +L +
Sbjct: 182 HDPQTRTS-APPCIFSSTTLNLEHHSSLGLQLQGPQTKTSASPRVFRCTTLKLEHQLLSE 240
Query: 3043 SPSAPDKPVVLPA---------IMPGDSFAVP 3065
SP P P V ++PG + A P
Sbjct: 241 SPKTPVPPQVFSCKTLKLEKHQLLPGSTAARP 272
>gi|98986457 host cell factor 1 [Homo sapiens]
Length = 2035
Score = 38.5 bits (88), Expect = 0.15
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 14/127 (11%)
Query: 4080 VSNSAAKFAGTLSDGLGKTMDNR-HQSEREYIRYHAATSGEHLVAGIHGLAHGIIGGLTS 4138
VSN A + T + +G ++ + + S R I H SG VA + ++GG+T
Sbjct: 602 VSNPATRMLKTAAAQVGTSVSSATNTSTRPIITVHK--SGTVTVAQQAQVVTTVVGGVTK 659
Query: 4139 VITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQ 4198
IT + GG S IS LGK + TKPV ++ T QA +GP TQ
Sbjct: 660 TITLVKSPISVPGG-SALISNLGKVMSVVQTKPV----QTSAVTGQA------STGPVTQ 708
Query: 4199 AQRVRKP 4205
+ + P
Sbjct: 709 IIQTKGP 715
>gi|148727247 ubiquitin specific peptidase 5 isoform 2 [Homo sapiens]
Length = 835
Score = 37.7 bits (86), Expect = 0.25
Identities = 30/88 (34%), Positives = 40/88 (45%), Gaps = 10/88 (11%)
Query: 2616 LPGASRVGEEIREGTRHTLDPVLELQLARLQELGFSMDDCRKALLACQGQLKKAASWLFK 2675
LPG+S G T DP E + + +GFS D KAL A L++A W+F
Sbjct: 684 LPGSSGPGS-----TSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFS 738
Query: 2676 NAEPLKSLSLASTSRD-SPGAVAAPLIS 2702
+ + L A + D S G AA IS
Sbjct: 739 HIDDLD----AEAAMDISEGRSAADSIS 762
>gi|148727331 ubiquitin specific peptidase 5 isoform 1 [Homo sapiens]
Length = 858
Score = 37.7 bits (86), Expect = 0.25
Identities = 30/88 (34%), Positives = 40/88 (45%), Gaps = 10/88 (11%)
Query: 2616 LPGASRVGEEIREGTRHTLDPVLELQLARLQELGFSMDDCRKALLACQGQLKKAASWLFK 2675
LPG+S G T DP E + + +GFS D KAL A L++A W+F
Sbjct: 707 LPGSSGPGS-----TSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFS 761
Query: 2676 NAEPLKSLSLASTSRD-SPGAVAAPLIS 2702
+ + L A + D S G AA IS
Sbjct: 762 HIDDLD----AEAAMDISEGRSAADSIS 785
>gi|171846268 Ts translation elongation factor, mitochondrial
precursor [Homo sapiens]
Length = 325
Score = 37.7 bits (86), Expect = 0.25
Identities = 17/40 (42%), Positives = 25/40 (62%)
Query: 2639 ELQLARLQELGFSMDDCRKALLACQGQLKKAASWLFKNAE 2678
EL + ++ G+S +C+KAL C G LK+A WL K A+
Sbjct: 48 ELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQ 87
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 35.8 bits (81), Expect = 0.96
Identities = 75/332 (22%), Positives = 140/332 (42%), Gaps = 41/332 (12%)
Query: 95 QDFNDEKEKLLERERKKALL---QALEEKWKNDR-------QQKGESYWYSVTASVVTRI 144
+DF EK + +R KALL Q + + KN Q K + T + +
Sbjct: 1646 RDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKA 1705
Query: 145 VENIELKIQDVHLRFED---GVTNPSHPFAFGICIKNVSMQNAV---NEPVQKLMRKKQL 198
+ +E++I+D+HL+ +D T + KN +QN + E + +LM+K +
Sbjct: 1706 RKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN-EIQNRLEEDQEDMNELMKKHKA 1764
Query: 199 DVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLEPVFASALLKRNCSKKPLR 258
VA+ S D + DL Q +L+EA E + L+ L+++ K L
Sbjct: 1765 AVAQAS----RDLAQINDL-QAQLEEANKEKQELQEKLQALQS--QVEFLEQSMVDKSLV 1817
Query: 259 SRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVKFRRWKPKVAISKNCREW 318
SR +I +LET L+ + Q +++ L KE K + + ++N +
Sbjct: 1818 SRQEAKIR---ELET-RLEFERTQVKRLESLASRL--KENMEKLTEERDQRIAAENREKE 1871
Query: 319 WYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEE 378
L L + +E+ M AR + K ++L+ L S + + + +
Sbjct: 1872 QNKRLQRQLRDTKEE--------MGELARKEAEASRKK-HELEMDLESLEAANQSLQADL 1922
Query: 379 EQSFEELKILRELVHDRFH--KQEELAESLRE 408
+ +F+ + L+ + D + E+L SL++
Sbjct: 1923 KLAFKRIGDLQAAIEDEMESDENEDLINSLQD 1954
>gi|134152667 ICBP90 binding protein 1 [Homo sapiens]
Length = 1440
Score = 35.4 bits (80), Expect = 1.2
Identities = 17/53 (32%), Positives = 34/53 (64%), Gaps = 1/53 (1%)
Query: 2 LEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKE-LELP 53
+ G++ + +L ++ NL+ D+++++ LKG +L NL L ++ L+ LELP
Sbjct: 1 MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGQLTNLELDEEVLQNVLELP 53
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 35.0 bits (79), Expect = 1.6
Identities = 76/337 (22%), Positives = 140/337 (41%), Gaps = 41/337 (12%)
Query: 95 QDFNDEKEKLLERERKKALL---QALEEKWKNDR-------QQKGESYWYSVTASVVTRI 144
+DF EK + +R KALL Q + + KN Q K + T + +
Sbjct: 1646 RDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKA 1705
Query: 145 VENIELKIQDVHLRFED---GVTNPSHPFAFGICIKNVSMQNAV---NEPVQKLMRKKQL 198
+ +E++I+D+HL+ +D T + KN +QN + E + +LM+K +
Sbjct: 1706 RKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN-EIQNRLEEDQEDMNELMKKHKA 1764
Query: 199 DVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLEPVFASALLKRNCSKKPLR 258
VA+ S D + DL Q +L+EA E + L+ L+++ K L
Sbjct: 1765 AVAQAS----RDLAQINDL-QAQLEEANKEKQELQEKLQALQS--QVEFLEQSMVDKSLV 1817
Query: 259 SRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVKFRRWKPKVAISKNCREW 318
SR +I +LET L+ + Q +++ L KE K + + ++N +
Sbjct: 1818 SRQEAKIR---ELET-RLEFERTQVKRLESLASRL--KENMEKLTEERDQRIAAENREKE 1871
Query: 319 WYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEE 378
L L + +E+ M AR + K ++L+ L S + + + +
Sbjct: 1872 QNKRLQRQLRDTKEE--------MGELARKEAEASRKK-HELEMDLESLEAANQSLQADL 1922
Query: 379 EQSFEELKILRELVHDRFH--KQEELAESLREPQFDS 413
+ +F+ + L+ + D + E+L S + DS
Sbjct: 1923 KLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDS 1959
>gi|27734911 DAZ interacting protein 1-like [Homo sapiens]
Length = 767
Score = 34.3 bits (77), Expect = 2.8
Identities = 32/88 (36%), Positives = 39/88 (44%), Gaps = 15/88 (17%)
Query: 750 RKSRDGSASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSE-EQLQ-AH 807
R+S S TQ S L P +TPP SS G TPPFS E SE +++Q
Sbjct: 574 RQSHGSHGSSLTQVSAPAPHPGLHGPSSTPP---SSGPGMSTPPFSSEEDSEGDRVQRVS 630
Query: 808 LMSTKMYERYSLSFMDLQIMVGRVKDNW 835
L K+ R MV R KD+W
Sbjct: 631 LQPPKVPSR----------MVPRPKDDW 648
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 33.9 bits (76), Expect = 3.6
Identities = 33/123 (26%), Positives = 53/123 (43%), Gaps = 7/123 (5%)
Query: 1679 KNPDSKYKNLMVSRGAPKPSSLAQKEY------LSQSCPSVSNVEYPDMPRSLPSHMEEA 1732
K +K K+L+ S P PS + E+ +SQS S+ + + S S +
Sbjct: 802 KQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSS-SLKSSSNSNKETSGSSKNSSS 860
Query: 1733 PNVFQLYQRPTSASRKKQKEVQDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLV 1792
+ + + TS+S K+ KE PP +PT+D K K FDD + +L
Sbjct: 861 TSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKLVFDDRNYSADHYLQ 920
Query: 1793 DKK 1795
+ K
Sbjct: 921 EAK 923
>gi|75677385 neugrin [Homo sapiens]
Length = 291
Score = 33.5 bits (75), Expect = 4.7
Identities = 23/63 (36%), Positives = 35/63 (55%), Gaps = 6/63 (9%)
Query: 2069 LQDKES--VPSASPTGIPKHSLRKTTSTEEPRGTHSQGQFTMPLAGMSLGSLKSEFVPST 2126
+QD E VP A+P G P+ + ++ +E PRGT G +P +G L LK+E +
Sbjct: 214 IQDLEESFVPVAAPLGHPRELQKYSSDSESPRGT---GSGALP-SGQKLEELKAEEPDNF 269
Query: 2127 STK 2129
S+K
Sbjct: 270 SSK 272
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 33.5 bits (75), Expect = 4.7
Identities = 41/198 (20%), Positives = 88/198 (44%), Gaps = 24/198 (12%)
Query: 221 ELQEAMAR--SMESRSHHYVLEPVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKL 278
ELQ A++ + ++ Y+ E L + + + + + ++Q + L+L
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEK---LRL 198
Query: 279 SQLQYRQIMEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANLYEIREQRKRCT 338
++ + +I +KEL+RK + KF P+V + E W E+REQ K+
Sbjct: 199 AESEKSEIQLNVKELKRKLERAKF--LLPQVQTNTLQEEMW-----RQEEELREQEKK-- 249
Query: 339 WDFMLHRARDAVSYTDKYFNKLKGGLLSTDDK----EEMCRIEEEQSFEELKILRELVHD 394
+ + + + ++ + +G + ++K E+ R +E++ E+ K LRE
Sbjct: 250 ----IRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE--QK 303
Query: 395 RFHKQEELAESLREPQFD 412
+ +QEE + E ++
Sbjct: 304 KLREQEEQMQEQEEKMWE 321
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 166,164,587
Number of Sequences: 37866
Number of extensions: 7767429
Number of successful extensions: 24500
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 24106
Number of HSP's gapped (non-prelim): 293
length of query: 4363
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4240
effective length of database: 13,590,000
effective search space: 57621600000
effective search space used: 57621600000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.