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Search of human proteins with 54607053
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54607053 GCN1 general control of amino-acid synthesis 1-like
1 [Homo sapiens]
(2671 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ... 5153 0.0
gi|122937211 KIAA0368 protein [Homo sapiens] 59 6e-08
gi|21361399 alpha isoform of regulatory subunit A, protein phosp... 54 3e-06
gi|32455246 beta isoform of regulatory subunit A, protein phosph... 52 8e-06
gi|32455244 beta isoform of regulatory subunit A, protein phosph... 52 8e-06
gi|157388904 HEAT repeat containing 2 [Homo sapiens] 50 4e-05
gi|62460637 importin 4 [Homo sapiens] 47 3e-04
gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens] 42 0.008
gi|21361794 TIP120 protein [Homo sapiens] 41 0.018
gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens] 40 0.024
gi|27477070 BTAF1 RNA polymerase II, B-TFIID transcription facto... 40 0.031
gi|4504811 junction plakoglobin [Homo sapiens] 39 0.053
gi|12056468 junction plakoglobin [Homo sapiens] 39 0.053
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 39 0.069
gi|148746195 trichohyalin [Homo sapiens] 39 0.090
gi|57863301 CLIP-associating protein 2 [Homo sapiens] 39 0.090
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 38 0.12
gi|110815815 centlein isoform 1 [Homo sapiens] 38 0.12
gi|167555106 centlein isoform 2 [Homo sapiens] 38 0.12
gi|156766050 AHNAK nucleoprotein 2 [Homo sapiens] 37 0.20
gi|148352331 cell division cycle 10 isoform 1 [Homo sapiens] 37 0.26
gi|148352329 cell division cycle 10 isoform 2 [Homo sapiens] 37 0.26
gi|54112117 splicing factor 3b, subunit 1 isoform 1 [Homo sapiens] 37 0.26
gi|24308179 CTTNBP2 N-terminal like [Homo sapiens] 37 0.26
gi|4504901 karyopherin alpha 4 [Homo sapiens] 37 0.26
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 37 0.34
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 37 0.34
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso... 36 0.44
gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso... 36 0.44
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof... 36 0.44
>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
[Homo sapiens]
Length = 2671
Score = 5153 bits (13366), Expect = 0.0
Identities = 2671/2671 (100%), Positives = 2671/2671 (100%)
Query: 1 MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHR 60
MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHR
Sbjct: 1 MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHR 60
Query: 61 YRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALTWT 120
YRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALTWT
Sbjct: 61 YRDAASRRALQAAIQQLAEAQPEATAKNLLHSLQSSGIGSKAGVPSKSSGSAALLALTWT 120
Query: 121 CLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDGAVKKLTKLWKENPGLV 180
CLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDGAVKKLTKLWKENPGLV
Sbjct: 121 CLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDGAVKKLTKLWKENPGLV 180
Query: 181 EQYLSAILSLEPNQNYAGMLGLLVQFCTSHKEMDVVSQHKSALLDFYMKNILMSKVKPPK 240
EQYLSAILSLEPNQNYAGMLGLLVQFCTSHKEMDVVSQHKSALLDFYMKNILMSKVKPPK
Sbjct: 181 EQYLSAILSLEPNQNYAGMLGLLVQFCTSHKEMDVVSQHKSALLDFYMKNILMSKVKPPK 240
Query: 241 YLLDSCAPLLRYLSHSEFKDLILPTIQKSLLRSPENVIETISSLLASVTLDLSQYAMDIV 300
YLLDSCAPLLRYLSHSEFKDLILPTIQKSLLRSPENVIETISSLLASVTLDLSQYAMDIV
Sbjct: 241 YLLDSCAPLLRYLSHSEFKDLILPTIQKSLLRSPENVIETISSLLASVTLDLSQYAMDIV 300
Query: 301 KGLAGHLKSNSPRLMDEAVLALRNLARQCSDSSAMESLTKHLFAILGGSEGKLTVVAQKM 360
KGLAGHLKSNSPRLMDEAVLALRNLARQCSDSSAMESLTKHLFAILGGSEGKLTVVAQKM
Sbjct: 301 KGLAGHLKSNSPRLMDEAVLALRNLARQCSDSSAMESLTKHLFAILGGSEGKLTVVAQKM 360
Query: 361 SVLSGIGSVSHHVVSGPSSQVLNGIVAELFIPFLQQEVHEGTLVHAVSVLALWCNRFTME 420
SVLSGIGSVSHHVVSGPSSQVLNGIVAELFIPFLQQEVHEGTLVHAVSVLALWCNRFTME
Sbjct: 361 SVLSGIGSVSHHVVSGPSSQVLNGIVAELFIPFLQQEVHEGTLVHAVSVLALWCNRFTME 420
Query: 421 VPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLASYRGDTLLQALDLLPLLIQTVEKAASQS 480
VPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLASYRGDTLLQALDLLPLLIQTVEKAASQS
Sbjct: 421 VPKKLTEWFKKAFSLKTSTSAVRHAYLQCMLASYRGDTLLQALDLLPLLIQTVEKAASQS 480
Query: 481 TQVPTITEGVAAALLLLKLSVADSQAEAKLSSFWQLIVDEKKQVFTSEKFLVMASEDALC 540
TQVPTITEGVAAALLLLKLSVADSQAEAKLSSFWQLIVDEKKQVFTSEKFLVMASEDALC
Sbjct: 481 TQVPTITEGVAAALLLLKLSVADSQAEAKLSSFWQLIVDEKKQVFTSEKFLVMASEDALC 540
Query: 541 TVLHLTERLFLDHPHRLTGNKVQQYHRALVAVLLSRTWHVRRQAQQTVRKLLSSLGGFKL 600
TVLHLTERLFLDHPHRLTGNKVQQYHRALVAVLLSRTWHVRRQAQQTVRKLLSSLGGFKL
Sbjct: 541 TVLHLTERLFLDHPHRLTGNKVQQYHRALVAVLLSRTWHVRRQAQQTVRKLLSSLGGFKL 600
Query: 601 AHGLLEELKTVLSSHKVLPLEALVTDAGEVTEAGKAYVPPRVLQEALCVISGVPGLKGDV 660
AHGLLEELKTVLSSHKVLPLEALVTDAGEVTEAGKAYVPPRVLQEALCVISGVPGLKGDV
Sbjct: 601 AHGLLEELKTVLSSHKVLPLEALVTDAGEVTEAGKAYVPPRVLQEALCVISGVPGLKGDV 660
Query: 661 TDTEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFITRHLDQIIPRMTTQSPLN 720
TDTEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFITRHLDQIIPRMTTQSPLN
Sbjct: 661 TDTEQLAQEMLIISHHPSLVAVQSGLWPALLARMKIDPEAFITRHLDQIIPRMTTQSPLN 720
Query: 721 QSSMNAMGSLSVLSPDRVLPQLISTITASVQNPALRLVTREEFAIMQTPAGELYDKSIIQ 780
QSSMNAMGSLSVLSPDRVLPQLISTITASVQNPALRLVTREEFAIMQTPAGELYDKSIIQ
Sbjct: 721 QSSMNAMGSLSVLSPDRVLPQLISTITASVQNPALRLVTREEFAIMQTPAGELYDKSIIQ 780
Query: 781 SAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDR 840
SAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDR
Sbjct: 781 SAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDR 840
Query: 841 EAQVRRRLQELDGELEAALGLLDIILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKNP 900
EAQVRRRLQELDGELEAALGLLDIILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKNP
Sbjct: 841 EAQVRRRLQELDGELEAALGLLDIILAKNPSGLTQYIPVLVDSFLPLLKSPLAAPRIKNP 900
Query: 901 FLSLAACVMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVKRAVMLLHTHTIT 960
FLSLAACVMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVKRAVMLLHTHTIT
Sbjct: 901 FLSLAACVMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVKRAVMLLHTHTIT 960
Query: 961 SRVGKGEPGAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEEWMAQILQILTVQAQLRASP 1020
SRVGKGEPGAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEEWMAQILQILTVQAQLRASP
Sbjct: 961 SRVGKGEPGAAPLSAPAFSLVFPFLKMVLTEMPHHSEEEEEWMAQILQILTVQAQLRASP 1020
Query: 1021 NTPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLTTLCASSSGDDGCAFAE 1080
NTPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLTTLCASSSGDDGCAFAE
Sbjct: 1021 NTPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLTTLCASSSGDDGCAFAE 1080
Query: 1081 QEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEE 1140
QEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEE
Sbjct: 1081 QEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEE 1140
Query: 1141 IRKLAERLWSMMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGR 1200
IRKLAERLWSMMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGR
Sbjct: 1141 IRKLAERLWSMMGLDLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGR 1200
Query: 1201 LMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQYLDSSQVKPLFQFF 1260
LMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQYLDSSQVKPLFQFF
Sbjct: 1201 LMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKLSQYLDSSQVKPLFQFF 1260
Query: 1261 VPDALNDRHPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVV 1320
VPDALNDRHPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVV
Sbjct: 1261 VPDALNDRHPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVV 1320
Query: 1321 VLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQR 1380
VLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQR
Sbjct: 1321 VLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQR 1380
Query: 1381 LMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALF 1440
LMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALF
Sbjct: 1381 LMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALF 1440
Query: 1441 AFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLP 1500
AFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLP
Sbjct: 1441 AFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLP 1500
Query: 1501 SLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQ 1560
SLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQ
Sbjct: 1501 SLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQ 1560
Query: 1561 ALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIV 1620
ALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIV
Sbjct: 1561 ALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIV 1620
Query: 1621 QRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKA 1680
QRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKA
Sbjct: 1621 QRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKA 1680
Query: 1681 LGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIV 1740
LGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIV
Sbjct: 1681 LGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIV 1740
Query: 1741 ATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRA 1800
ATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRA
Sbjct: 1741 ATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRA 1800
Query: 1801 GQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASE 1860
GQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASE
Sbjct: 1801 GQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASE 1860
Query: 1861 DDNFGTAQSNKAIITALGVERRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLR 1920
DDNFGTAQSNKAIITALGVERRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLR
Sbjct: 1861 DDNFGTAQSNKAIITALGVERRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLR 1920
Query: 1921 EILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDER 1980
EILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDER
Sbjct: 1921 EILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDER 1980
Query: 1981 QGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQA 2040
QGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQA
Sbjct: 1981 QGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQA 2040
Query: 2041 LEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSV 2100
LEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSV
Sbjct: 2041 LEDILPFLLKQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSV 2100
Query: 2101 AGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEAT 2160
AGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEAT
Sbjct: 2101 AGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEAT 2160
Query: 2161 RSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAIT 2220
RSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAIT
Sbjct: 2161 RSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAIT 2220
Query: 2221 KKLDAGNQLALIEELHKEIRLIGNESKGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQK 2280
KKLDAGNQLALIEELHKEIRLIGNESKGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQK
Sbjct: 2221 KKLDAGNQLALIEELHKEIRLIGNESKGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQK 2280
Query: 2281 EEAAKALGLVIRLTSADALRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIA 2340
EEAAKALGLVIRLTSADALRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIA
Sbjct: 2281 EEAAKALGLVIRLTSADALRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIA 2340
Query: 2341 LKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFTELLNGIRAMEDPGV 2400
LKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFTELLNGIRAMEDPGV
Sbjct: 2341 LKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFTELLNGIRAMEDPGV 2400
Query: 2401 RDTMLQALRFVIQGAGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEE 2460
RDTMLQALRFVIQGAGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEE
Sbjct: 2401 RDTMLQALRFVIQGAGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEE 2460
Query: 2461 ELSAVLQQCLLADVSGIDWMVRHGRSLALSVAVNVAPGRLCAGRYSSDVQEMILSSATAD 2520
ELSAVLQQCLLADVSGIDWMVRHGRSLALSVAVNVAPGRLCAGRYSSDVQEMILSSATAD
Sbjct: 2461 ELSAVLQQCLLADVSGIDWMVRHGRSLALSVAVNVAPGRLCAGRYSSDVQEMILSSATAD 2520
Query: 2521 RIPIAVSGVRGMGFLMRHHIETGGGQLPAKLSSLFVKCLQNPSSDIRLVAEKMIWWANKD 2580
RIPIAVSGVRGMGFLMRHHIETGGGQLPAKLSSLFVKCLQNPSSDIRLVAEKMIWWANKD
Sbjct: 2521 RIPIAVSGVRGMGFLMRHHIETGGGQLPAKLSSLFVKCLQNPSSDIRLVAEKMIWWANKD 2580
Query: 2581 PLPPLDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLSKILDVAS 2640
PLPPLDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLSKILDVAS
Sbjct: 2581 PLPPLDPQAIKPILKALLDNTKDKNTVVRAYSDQAIVNLLKMRQGEEVFQSLSKILDVAS 2640
Query: 2641 LEVLNEVNRRSLKKLASQADSTEQVDDTILT 2671
LEVLNEVNRRSLKKLASQADSTEQVDDTILT
Sbjct: 2641 LEVLNEVNRRSLKKLASQADSTEQVDDTILT 2671
>gi|122937211 KIAA0368 protein [Homo sapiens]
Length = 2017
Score = 58.9 bits (141), Expect = 6e-08
Identities = 105/554 (18%), Positives = 207/554 (37%), Gaps = 70/554 (12%)
Query: 1292 VNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLD---KSDPKVKPIVAKLIAAL 1348
VN ++P + + N + VRQ+ + + SL + L + +K I + ++ L
Sbjct: 1107 VNDVVPWVLDVILNKHIISPNPHVRQAACIWLLSLVRKLSTHKEVKSHLKEIQSAFVSVL 1166
Query: 1349 STPSQQVQESVASCLPPLVPAI--KEDAGGMIQRLMQQLLESDKYAER--------KGAA 1398
S + ++ + VAS LV + ++D ++ L++ L+ + +G A
Sbjct: 1167 SE-NDELSQDVASKGLGLVYELGNEQDQQELVSTLVETLMTGKRVKHEVSGETVVFQGGA 1225
Query: 1399 YGLAGLVKGLGILS--------LKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLG 1450
G +GL L Q +++ + + R+GA F F ++ T G
Sbjct: 1226 LGKTPDGQGLSTYKELCSLASDLSQPDLVYKFMNLANHHAMWNSRKGAAFGFNVIATRAG 1285
Query: 1451 KLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSA--HGVKLVLPSLLAALEE 1508
+ P++ ++P L D N +R+A A++++ S +K +L L+ L
Sbjct: 1286 EQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIWNALVTDKSMVDKYLKEILQDLVKNLTS 1345
Query: 1509 ESWRTKAGSVELLGAMAYCAP-KQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGS 1567
WR + S L + P + LP I L V D V+KA + AL+ +
Sbjct: 1346 NMWRVRESSCLALNDLLRGRPLDDIIDKLPEIWETLFRVQDDIKESVRKAAELALKTLSK 1405
Query: 1568 VIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMP-IVQRAFQD 1626
V + DP++ ++A ++P ++ +
Sbjct: 1406 VCVK-------------MCDPAKGA---------------AGQRTIAALLPCLLDKGMMS 1437
Query: 1627 RSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVK 1686
T+ R ++ + + S + L P+ P + P L SL P+V + K
Sbjct: 1438 TVTEVRALSINTLVKI-SKSAGAMLKPHAPKLIPALLESLSVLEPQVLNYLSLRATEQEK 1496
Query: 1687 GMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKV 1746
+S S+ S + + + L V L +L+P + +
Sbjct: 1497 AAMDSA--------------RLSAAKSSPMMETINMCLQYLDVSVLGELVPRL-CELIRS 1541
Query: 1747 DIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVIS 1806
+ + G + L TPY G ++ +L L D N ++ + A ++
Sbjct: 1542 GVGLGTKGGCASVIVSLTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAFAMGHLVR 1601
Query: 1807 MYAETAIALLLPQL 1820
+++ LL +L
Sbjct: 1602 TSRDSSTEKLLQKL 1615
Score = 42.4 bits (98), Expect = 0.006
Identities = 52/224 (23%), Positives = 99/224 (44%), Gaps = 31/224 (13%)
Query: 1645 LTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETL 1704
L+ K++ +L + + L + + V++K LG + + E ++L+ L+ETL
Sbjct: 1145 LSTHKEVKSHLKEIQSAFVSVLSENDELSQDVASKGLGLVYELGNEQDQQELVSTLVETL 1204
Query: 1705 -TYEQSSVDRSGAA---QG--LAEVMAGLGVEKLEKL--------MPEIVATASKVDIAP 1750
T ++ + SG QG L + G G+ ++L P++V +++A
Sbjct: 1205 MTGKRVKHEVSGETVVFQGGALGKTPDGQGLSTYKELCSLASDLSQPDLVYKF--MNLAN 1262
Query: 1751 H-----VRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDT------ALR 1799
H R G FN + G++ P++ ++P + + D N +R AL
Sbjct: 1263 HHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIWNALV 1322
Query: 1800 AGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLL 1843
+ ++ Y + +L L + L ++WR+R SS L DLL
Sbjct: 1323 TDKSMVDKYLKE----ILQDLVKNLTSNMWRVRESSCLALNDLL 1362
Score = 40.0 bits (92), Expect = 0.031
Identities = 50/235 (21%), Positives = 91/235 (38%), Gaps = 24/235 (10%)
Query: 2162 SPEVGMRQAAAIILNIYCSR--SKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAI 2219
SP +RQAA I L + + + SHL+ + S + + +++ + + + L +
Sbjct: 1125 SPNPHVRQAACIWLLSLVRKLSTHKEVKSHLKEIQSAFVSVLSENDELSQDVASKGLGLV 1184
Query: 2220 TKKLDAGNQLALIEELHKEIRLIGNESKGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQ 2279
+ + +Q L+ L E + G K E V+ V + G L +P+
Sbjct: 1185 YELGNEQDQQELVSTL-VETLMTGKRVKHE-----------VSGETVVFQGGALGKTPD- 1231
Query: 2280 KEEAAKALGLVIRLTS--ADALRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKV 2337
+ L L S +D +P +V + + WN + +++ +
Sbjct: 1232 ----GQGLSTYKELCSLASDLSQPDLVY---KFMNLANHHAMWNSRKGAAFGFNVIATRA 1284
Query: 2338 GIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFTELLNGI 2392
G L PFLPQL + D N G+R L++ VD E+L +
Sbjct: 1285 GEQLAPFLPQLVPRLYRYQFDPNLGIRQAMTSIWNALVTDKSMVDKYLKEILQDL 1339
Score = 33.5 bits (75), Expect = 2.9
Identities = 59/310 (19%), Positives = 120/310 (38%), Gaps = 45/310 (14%)
Query: 1954 RKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKA 2013
+ + +K L EI+ L + L S R+ C+ L+++++ D ++ + T +
Sbjct: 1325 KSMVDKYLKEILQDLVKNLTSNMWRVRESSCLALNDLLRGRPLDDIIDKLPEIWETLFRV 1384
Query: 2014 LCDPLEEVREAA-----------AKTFEQLHSTIGHQALEDILPFLLKQ---LDDEEVSE 2059
D E VR+AA K + G + + +LP LL + EV
Sbjct: 1385 QDDIKESVRKAAELALKTLSKVCVKMCDPAKGAAGQRTIAALLPCLLDKGMMSTVTEVRA 1444
Query: 2060 FALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLA 2119
+++ L ++ ++ P+ PKL AL L V+ P V+
Sbjct: 1445 LSINTLVKISKSAGAMLKPH-APKLI-----------------PALLESLSVLEPQVLNY 1486
Query: 2120 L------KEKLGTPDEQLEMANCQAVILSVE------DDTGHRIIIEDLLEATRS-PEVG 2166
L +EK +L A ++ ++ D + ++ L E RS +G
Sbjct: 1487 LSLRATEQEKAAMDSARLSAAKSSPMMETINMCLQYLDVSVLGELVPRLCELIRSGVGLG 1546
Query: 2167 MRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAG 2226
+ A ++ ++ D T + L+S L+ D + V+ + A+ + +
Sbjct: 1547 TKGGCASVIVSLTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAFAMGHLVRTSRDS 1606
Query: 2227 NQLALIEELH 2236
+ L+++L+
Sbjct: 1607 STEKLLQKLN 1616
>gi|21361399 alpha isoform of regulatory subunit A, protein
phosphatase 2 [Homo sapiens]
Length = 589
Score = 53.5 bits (127), Expect = 3e-06
Identities = 124/590 (21%), Positives = 217/590 (36%), Gaps = 62/590 (10%)
Query: 1401 LAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVH- 1459
L+ + LG+ + E++ LTD I D+ E L E L T + P VH
Sbjct: 35 LSTIALALGV-ERTRSELLPFLTDTIYDED-----EVLLALAEQLGTFTTLVGGPEYVHC 88
Query: 1460 VLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVE 1519
+LP L VR+ A + +A+ S ++ L+ L W T S
Sbjct: 89 LLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSA- 147
Query: 1520 LLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAP 1579
G + C P+ S+ + + +D V++A L + V+ + +
Sbjct: 148 -CGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEII 206
Query: 1580 VLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSL-ALIMPIVQRAFQDRSTDTRKMAAQI 1638
+ L + + + L + L AL+MP +++A +D+S R M A
Sbjct: 207 PMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADK 266
Query: 1639 IGNMYSLTDQKDLAPYL--PSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDL 1696
+ QK + P + + P + + D EVR ++ + + + C E++
Sbjct: 267 FTEL-----QKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENV 321
Query: 1697 LPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGV-----EKLEKLMPEIVATASKVDIAPH 1751
+ + E S LA V+ GL +E L+P +A D P
Sbjct: 322 IMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLK--DECPE 379
Query: 1752 VRDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRVISMYAET 1811
VR I + + G + + +L A+ E D R +I
Sbjct: 380 VRLNIISNLDCVNEVIG------IRQLSQSLLPAIV---ELAEDAKWRVRLAIIEY---- 426
Query: 1812 AIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNK 1871
+ LL QL FD+ + +S+ + L+ H+ + T+ + FG ++
Sbjct: 427 -MPLLAGQLGVEFFDE----KLNSL-CMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA 480
Query: 1872 AIITALGVERRNRVLAGLYMGRSDTQLVVRQASLHVWKIV--VSNTPRTLREILPTLFGL 1929
II +VLA D + R +L ++ V T + +LPT
Sbjct: 481 TIIP--------KVLA----MSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPT---- 524
Query: 1930 LLGFLASTCADKRTIAARTLGDLVRKLGEKIL-PEIIPILEEGLRSQKSD 1978
+L A+ R A++L + L L E+ PILE+ + Q D
Sbjct: 525 VLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVD 574
Score = 48.1 bits (113), Expect = 1e-04
Identities = 76/351 (21%), Positives = 131/351 (37%), Gaps = 54/351 (15%)
Query: 1778 IIPCILKALADENEFVRDTALRAGQRVISMYAETAI-ALLLPQLEQGLFDDLWRIRFSSV 1836
IIP +DE + VR A+ A + + + + AL++P L Q D WR+R+
Sbjct: 205 IIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRY--- 261
Query: 1837 QLLGDLLFHISGVTGKMTTET------------ASEDDNFGTAQSNKAIITALGVERRNR 1884
++ D + G T+T + + K L + R
Sbjct: 262 -MVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCREN 320
Query: 1885 VLAGLYMGRSDTQLVVRQASLHVWKIVVS---------NTPRTLREILPTLFGLLLGFLA 1935
V+ + + +V A+ HV + S T+ +LP L L L
Sbjct: 321 VIMSQIL--PCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLP----LFLAQLK 374
Query: 1936 STCADKRTIAARTLGDL-----VRKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEI 1990
C + R L + +R+L + +LP I+ + E D + V + + E
Sbjct: 375 DECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAE--------DAKWRVRLAIIEY 426
Query: 1991 MKSTSRD-AVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQ-ALEDILPFL 2048
M + V +F E L L D + +REAA ++L G + A I+P +
Sbjct: 427 MPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKV 486
Query: 2049 LKQLDDEE-----VSEFALDGLKQVMA--IKSRVVLPYLVPKLTTPPVNTR 2092
L D + F ++ L +V I ++ +LP ++ P N R
Sbjct: 487 LAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVR 537
>gi|32455246 beta isoform of regulatory subunit A, protein phosphatase
2 isoform a [Homo sapiens]
Length = 601
Score = 52.0 bits (123), Expect = 8e-06
Identities = 63/352 (17%), Positives = 143/352 (40%), Gaps = 16/352 (4%)
Query: 1460 VLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVK-LVLPSLLAALEEESWRTKAGSV 1518
++P D VR A + ++ LS ++ LV+P+L A E++SWR +
Sbjct: 217 IVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVA 276
Query: 1519 ELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGS--VIRNPEIL- 1575
+ + +++ L +++P +L D +V+ A ++++G I + E +
Sbjct: 277 DRFSELQKAMGPKIT--LNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETII 334
Query: 1576 --AIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRK 1633
I P + + ++D ++ + L +++ ++ ++P+ +D D R
Sbjct: 335 MNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVR- 393
Query: 1634 MAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCF 1693
II N+ + + + S+ P + D VR + + + +G F
Sbjct: 394 --LNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFF 451
Query: 1694 EDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEK-LMPEIVATASKVDIAPHV 1752
++ L L + R A L +++ G E + ++P+++ A+ + +
Sbjct: 452 DEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRM 511
Query: 1753 RDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRV 1804
+ N L G + T ++P +LK D+ VR ++ Q++
Sbjct: 512 TT--LFCINALSEACGQEIT--TKQMLPIVLKMAGDQVANVRFNVAKSLQKI 559
Score = 48.9 bits (115), Expect = 7e-05
Identities = 80/350 (22%), Positives = 135/350 (38%), Gaps = 52/350 (14%)
Query: 1778 IIPCILKALADENEFVRDTALRAGQRVISMYAETAI-ALLLPQLEQGLFDDLWRI----- 1831
I+P +DE + VR A+ A + + ++ + L++P L Q D WR+
Sbjct: 217 IVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVA 276
Query: 1832 -RFSSVQ-------LLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVERR- 1882
RFS +Q L DL+ + E + A K + L +E R
Sbjct: 277 DRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRA-----AAAHKVKELGENLPIEDRE 331
Query: 1883 ----NRVLAGLYMGRSDTQLVVRQ--ASLHVWKIVVSNTPRTLREILPTLFGLLLGFLAS 1936
N++L + SDT V+ AS+ + + T+ +LP L L L
Sbjct: 332 TIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLP----LFLAQLKD 387
Query: 1937 TCADKRTIAARTLGDL-----VRKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEIM 1991
C D R L + +R+L + +LP I+ + E D + V + + E M
Sbjct: 388 ECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAE--------DAKWRVRLAIIEYM 439
Query: 1992 KSTSRD-AVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQ-ALEDILPFLL 2049
+ V +F E L L D + +REAA +L G + A I+P +L
Sbjct: 440 PLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVL 499
Query: 2050 KQLDDEE-----VSEFALDGLKQV--MAIKSRVVLPYLVPKLTTPPVNTR 2092
+D + F ++ L + I ++ +LP ++ N R
Sbjct: 500 VMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVR 549
Score = 42.0 bits (97), Expect = 0.008
Identities = 120/526 (22%), Positives = 209/526 (39%), Gaps = 84/526 (15%)
Query: 1068 ASSSGDDGCAFAEQEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLL 1127
A GDD + VL+ L++ +R ++ L + + L E+ LL
Sbjct: 14 AGGDGDDSLY-----PIAVLIDELRNEDVQLRLNSIKKLSTIALALGV----ERTRSELL 64
Query: 1128 RRLWVVKFDKEEEIRKLAERLWSMMGLDLQPDLCSLLIDDV----IYHEAAVRQAGAEAL 1183
L +D++E + LAE+L + GL PD L+ + E VR E+L
Sbjct: 65 PFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESL 124
Query: 1184 SQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNK 1243
Q + A E Y P V R+ S + CGL
Sbjct: 125 RQISQEHTPVALEA------------YFVPLV----KRLASGDWFTSRTSACGLFSVCYP 168
Query: 1244 LSQYLDSSQVKPLFQFFVPDALNDRHPDVRKCMLDAALATLNTHGK----ENVNS-LLPV 1298
+ ++++ F+ +D P VR+ AA + L K ++V S ++P+
Sbjct: 169 RASNAVKAEIRQQFR----SLCSDDTPMVRR----AAASKLGEFAKVLELDSVKSEIVPL 220
Query: 1299 FEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQES 1358
F + D+VR V S+A+ L + D + ++ L A S +V+
Sbjct: 221 FTSLASD-----EQDSVRLLAVEACVSIAQLLSQDDLETL-VMPTLRQAAEDKSWRVRYM 274
Query: 1359 VASCLPPLVPAI--KEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGI---LSL 1413
VA L A+ K +I Q LL+ + R AA+ + L + L I ++
Sbjct: 275 VADRFSELQKAMGPKITLNDLIP-AFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETI 333
Query: 1414 KQQEMMAALTDAIQDKKNFRRREGALFAFEM-LCTMLGKLFEPYVVHVLPHLLLCFGDGN 1472
+++ + + + D + + AL + M L T+LGK E + H+LP L
Sbjct: 334 IMNQILPYIKELVSDTN--QHVKSALASVIMGLSTILGK--ENTIEHLLPLFL------- 382
Query: 1473 QYVREAADDCAKAVMSNL----SAHGVKLVLPSLLAAL----EEESWRTKAGSVELLGAM 1524
+++ D ++SNL G++ + SLL A+ E+ WR + +E + +
Sbjct: 383 AQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLL 442
Query: 1525 A------YCAPKQLSSCLPNIVP---KLTEVLTDSHVK-VQKAGQQ 1560
A + K S C+ +V + E T++ +K VQK G +
Sbjct: 443 AGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTE 488
>gi|32455244 beta isoform of regulatory subunit A, protein phosphatase
2 isoform b [Homo sapiens]
Length = 667
Score = 52.0 bits (123), Expect = 8e-06
Identities = 63/352 (17%), Positives = 143/352 (40%), Gaps = 16/352 (4%)
Query: 1460 VLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVK-LVLPSLLAALEEESWRTKAGSV 1518
++P D VR A + ++ LS ++ LV+P+L A E++SWR +
Sbjct: 217 IVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVA 276
Query: 1519 ELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGS--VIRNPEIL- 1575
+ + +++ L +++P +L D +V+ A ++++G I + E +
Sbjct: 277 DRFSELQKAMGPKIT--LNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETII 334
Query: 1576 --AIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRK 1633
I P + + ++D ++ + L +++ ++ ++P+ +D D R
Sbjct: 335 MNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVR- 393
Query: 1634 MAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCF 1693
II N+ + + + S+ P + D VR + + + +G F
Sbjct: 394 --LNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFF 451
Query: 1694 EDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEK-LMPEIVATASKVDIAPHV 1752
++ L L + R A L +++ G E + ++P+++ A+ + +
Sbjct: 452 DEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRM 511
Query: 1753 RDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRV 1804
+ N L G + T ++P +LK D+ VR ++ Q++
Sbjct: 512 TT--LFCINALSEACGQEIT--TKQMLPIVLKMAGDQVANVRFNVAKSLQKI 559
Score = 48.9 bits (115), Expect = 7e-05
Identities = 80/350 (22%), Positives = 135/350 (38%), Gaps = 52/350 (14%)
Query: 1778 IIPCILKALADENEFVRDTALRAGQRVISMYAETAI-ALLLPQLEQGLFDDLWRI----- 1831
I+P +DE + VR A+ A + + ++ + L++P L Q D WR+
Sbjct: 217 IVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVA 276
Query: 1832 -RFSSVQ-------LLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVERR- 1882
RFS +Q L DL+ + E + A K + L +E R
Sbjct: 277 DRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRA-----AAAHKVKELGENLPIEDRE 331
Query: 1883 ----NRVLAGLYMGRSDTQLVVRQ--ASLHVWKIVVSNTPRTLREILPTLFGLLLGFLAS 1936
N++L + SDT V+ AS+ + + T+ +LP L L L
Sbjct: 332 TIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLP----LFLAQLKD 387
Query: 1937 TCADKRTIAARTLGDL-----VRKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEIM 1991
C D R L + +R+L + +LP I+ + E D + V + + E M
Sbjct: 388 ECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAE--------DAKWRVRLAIIEYM 439
Query: 1992 KSTSRD-AVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQ-ALEDILPFLL 2049
+ V +F E L L D + +REAA +L G + A I+P +L
Sbjct: 440 PLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVL 499
Query: 2050 KQLDDEE-----VSEFALDGLKQV--MAIKSRVVLPYLVPKLTTPPVNTR 2092
+D + F ++ L + I ++ +LP ++ N R
Sbjct: 500 VMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVR 549
Score = 42.0 bits (97), Expect = 0.008
Identities = 120/526 (22%), Positives = 209/526 (39%), Gaps = 84/526 (15%)
Query: 1068 ASSSGDDGCAFAEQEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLL 1127
A GDD + VL+ L++ +R ++ L + + L E+ LL
Sbjct: 14 AGGDGDDSLY-----PIAVLIDELRNEDVQLRLNSIKKLSTIALALGV----ERTRSELL 64
Query: 1128 RRLWVVKFDKEEEIRKLAERLWSMMGLDLQPDLCSLLIDDV----IYHEAAVRQAGAEAL 1183
L +D++E + LAE+L + GL PD L+ + E VR E+L
Sbjct: 65 PFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESL 124
Query: 1184 SQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNK 1243
Q + A E Y P V R+ S + CGL
Sbjct: 125 RQISQEHTPVALEA------------YFVPLV----KRLASGDWFTSRTSACGLFSVCYP 168
Query: 1244 LSQYLDSSQVKPLFQFFVPDALNDRHPDVRKCMLDAALATLNTHGK----ENVNS-LLPV 1298
+ ++++ F+ +D P VR+ AA + L K ++V S ++P+
Sbjct: 169 RASNAVKAEIRQQFR----SLCSDDTPMVRR----AAASKLGEFAKVLELDSVKSEIVPL 220
Query: 1299 FEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQES 1358
F + D+VR V S+A+ L + D + ++ L A S +V+
Sbjct: 221 FTSLASD-----EQDSVRLLAVEACVSIAQLLSQDDLETL-VMPTLRQAAEDKSWRVRYM 274
Query: 1359 VASCLPPLVPAI--KEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGI---LSL 1413
VA L A+ K +I Q LL+ + R AA+ + L + L I ++
Sbjct: 275 VADRFSELQKAMGPKITLNDLIP-AFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETI 333
Query: 1414 KQQEMMAALTDAIQDKKNFRRREGALFAFEM-LCTMLGKLFEPYVVHVLPHLLLCFGDGN 1472
+++ + + + D + + AL + M L T+LGK E + H+LP L
Sbjct: 334 IMNQILPYIKELVSDTN--QHVKSALASVIMGLSTILGK--ENTIEHLLPLFL------- 382
Query: 1473 QYVREAADDCAKAVMSNL----SAHGVKLVLPSLLAAL----EEESWRTKAGSVELLGAM 1524
+++ D ++SNL G++ + SLL A+ E+ WR + +E + +
Sbjct: 383 AQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLL 442
Query: 1525 A------YCAPKQLSSCLPNIVP---KLTEVLTDSHVK-VQKAGQQ 1560
A + K S C+ +V + E T++ +K VQK G +
Sbjct: 443 AGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTE 488
>gi|157388904 HEAT repeat containing 2 [Homo sapiens]
Length = 855
Score = 49.7 bits (117), Expect = 4e-05
Identities = 64/285 (22%), Positives = 112/285 (39%), Gaps = 23/285 (8%)
Query: 1531 QLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIG-----SVIRNPEILAIAPVLLDAL 1585
+LS L ++P L + +A ++AL + G + + P + P LL L
Sbjct: 26 ELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCL 85
Query: 1586 TDPSRKTQKCLQTLLDT----------KFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMA 1635
+DP+ + LLD + A + L P+ R + + R
Sbjct: 86 SDPAEGCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLAL 145
Query: 1636 AQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCF-- 1693
Q++G L LAP+L L+ SLLDP VR S A+ + +
Sbjct: 146 VQLLGLAVDLCGAA-LAPHLDDALRALRCSLLDPFAAVRRESCSCAAALAQATPDHFHMQ 204
Query: 1694 -EDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHV 1752
E L+ LM+T++++ V R A + V+ + ++ ++ D P V
Sbjct: 205 SESLIGPLMQTISHQHWKV-RVAAIEATGAVIHFGNGKSVDDVLSHFAQRL--FDDVPQV 261
Query: 1753 RDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTA 1797
R + + D+++ + +IP +L +L DE VR A
Sbjct: 262 RRAVASVVGGWLLCLRDRYS-FFHKLIPLLLSSLNDEVPEVRQLA 305
Score = 41.6 bits (96), Expect = 0.011
Identities = 132/595 (22%), Positives = 219/595 (36%), Gaps = 66/595 (11%)
Query: 1803 RVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDD 1862
R +S AE AL + L+ GL R R + +LL L ++G A E+
Sbjct: 83 RCLSDPAEGCRALAVHLLDLGLRRAA-RPRDALPRLLPALAARLAGPVPARRPPEACEEL 141
Query: 1863 NFGTAQSNKAIITALGVE---RRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTL 1919
Q + G + L L D VR+ S + TP
Sbjct: 142 RLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFAAVRRESCSCAAALAQATPDHF 201
Query: 1920 REILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDE 1979
+L G L+ ++ R A G ++ K + +++ + L
Sbjct: 202 HMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQV 261
Query: 1980 RQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLH---STI 2036
R+ V + + RD +F + L+P +L D + EVR+ AA +E +
Sbjct: 262 RRAVASVVGGWLLCL-RDRYSFFHK-LIPLLLSSLNDEVPEVRQLAASLWEDVGLQWQKE 319
Query: 2037 GHQALEDILPFLLKQLDDEEVSEFA-LDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRV-- 2093
+ L+D L F E + G ++++ +LP L +T V TRV
Sbjct: 320 NEEDLKDKLDFAPPTPPHYPPHERRPVLGCRELVFRNLSKILPALCHDITDWVVGTRVKS 379
Query: 2094 ---LAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVEDDTGHR 2150
L L A D T+HL V+L + A T +E + +C
Sbjct: 380 AQLLPVLLLHAEDHATQHLEVVLRTLFQAC-----TDEEAAVVQSC-------------- 420
Query: 2151 IIIEDLLEATRSPE-VGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVL 2209
TRS E VG + + L + S K ++ SGL+ L +
Sbjct: 421 ---------TRSAELVGTFVSPEVFLKLILSTLKKTPSA------SGLLVLASAMRGCPR 465
Query: 2210 EESWDALNAITKKLDAGNQLALIE-ELHKEIRLIGNESKGEHVPGFCLPKKGVTSI---- 2264
E L AI +L + E +L+ E L+ ++ + C GV S+
Sbjct: 466 EALQPHLAAIATELAQAHICQASENDLYLERLLLCVQA----LVSVCHEDCGVASLQLLD 521
Query: 2265 --LPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVSITGPLI-RILGDRFSWN 2321
L ++ TG ++ +E +L +V ++S L + GPL+ R+ W
Sbjct: 522 VLLTIVALAGATGLRDKAQETMDSLAMVEGVSSCQDLYRKHI---GPLLERVTASHLDWT 578
Query: 2322 VKAALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDS-NRGVRLKAADALGKLI 2375
+ L S+++A+ G AL LP + T LQ S + +RLK L ++
Sbjct: 579 AHSPELLQFSVIVAQSGPALGEALPHVVPTLRACLQPSQDPQMRLKLFSILSTVL 633
>gi|62460637 importin 4 [Homo sapiens]
Length = 1081
Score = 46.6 bits (109), Expect = 3e-04
Identities = 52/200 (26%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 1958 EKILPEIIPILEEGLRSQKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDP 2017
EK+ P+++P+LEE LRS+ +R+ + L+ + L+ K L DP
Sbjct: 347 EKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDP 406
Query: 2018 LEEVREAA----AKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSE--------FALDGL 2065
+ VR AA + E L I + E ++P LL L + +AL+
Sbjct: 407 SQVVRNAALFALGQFSENLQPHISSYSRE-VMPLLLAYLKSVPLGHTHHLAKACYALENF 465
Query: 2066 KQVMAIKSRVVLPYLVP---KLTTPPVNTRVLAFLSSVAGDALTRHLGVIL---PAVMLA 2119
+ + K + LP L+ +L P + R S G T +L PA+M
Sbjct: 466 VENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEH 525
Query: 2120 LKEKLGTPDEQLEMANCQAV 2139
L+E L T E L+ Q++
Sbjct: 526 LREFLLTGREDLQPVQIQSL 545
Score = 44.7 bits (104), Expect = 0.001
Identities = 88/374 (23%), Positives = 156/374 (41%), Gaps = 49/374 (13%)
Query: 1496 KLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQ 1555
++++P L+ A++ +A + E L A+ + L S +P I P L+EVLT ++
Sbjct: 200 RMLVPKLIMAMQTLIPIDEAKACEALEAL----DELLESEVPVITPYLSEVLTFC---LE 252
Query: 1556 KAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLAL 1615
A AL G+ IR IL L+ + K + L LL T F P +A
Sbjct: 253 VARNVAL---GNAIRI-RILCCLTFLVKVKSKALLKN-RLLPPLLHTLF------PIVAA 301
Query: 1616 IMPIVQRAFQDRSTDTRKMAAQIIGNM---YSLTDQKDLAPYLP------SVTPGLKASL 1666
P Q +D+ ++ ++ +++G +++ LA +LP + P L+ +L
Sbjct: 302 EPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEAL 361
Query: 1667 LDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETL---TYEQSSVDRSGAAQGLAEV 1723
P R L + G G+ + LLP L++ + + S V R+ A L +
Sbjct: 362 RSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQF 421
Query: 1724 MAGLG---VEKLEKLMPEIVATASKVDI--APHVRDGYIMMFNYLPITFGDKFTPYVGPI 1778
L ++MP ++A V + H+ + N++ G K PY+ +
Sbjct: 422 SENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVE-NLGPKVQPYLPEL 480
Query: 1779 IPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLP-------QLEQGLF---DDL 1828
+ C+L+ L + + A + A A A LLP L + L +DL
Sbjct: 481 MECMLQLLRNPSS---PRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDL 537
Query: 1829 WRIRFSSVQLLGDL 1842
++ S++ LG L
Sbjct: 538 QPVQIQSLETLGVL 551
>gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens]
Length = 1236
Score = 42.0 bits (97), Expect = 0.008
Identities = 133/618 (21%), Positives = 225/618 (36%), Gaps = 76/618 (12%)
Query: 1885 VLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTI 1944
V+ L D + RQ + + P +L E +P L ++ LA + TI
Sbjct: 437 VVKALQRQLKDRSVRARQGCFSLLTELAGVLPGSLAEHMPVLVSGIIFSLADRSSSS-TI 495
Query: 1945 AARTLGDLVRKLGEK-----------ILPEIIPILEEGLRSQKSDER---QGVCIGLSEI 1990
L L LG + +LP ++ + + ++ Q + L +
Sbjct: 496 RMDALAFLQGLLGTEPAEAFHPHLPILLPPVMACVADSFYKIAAEALVVLQELVRALWPL 555
Query: 1991 MKSTSRDAVLYFSE-SLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLL 2049
+ D Y E S V AR D +EV+E A L +G + +D+ P LL
Sbjct: 556 HRPRMLDPEPYVGEMSAVTLARLRATDLDQEVKERAISCMGHLVGHLGDRLGDDLEPTLL 615
Query: 2050 KQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPV--------------NTRVLA 2095
LD + + ++ AIK+ ++ +L P+ N R L
Sbjct: 616 LLLDRLR------NEITRLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKNQRALR 669
Query: 2096 FLSSVAGDALTRHLGVILP--AVMLALKEKLGTPDEQ-LEMANCQAVILSVEDDTGHRII 2152
+ A DAL + G+ LP AV L E +E + +A L+ +
Sbjct: 670 LATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQAQPASL 729
Query: 2153 IE-------DLLEATRSP--EVGMRQAAAIILNIYCSRSK--ADYTSHLRSLVSGLIRLF 2201
+E +LL RSP G+ AA L DY + L + +
Sbjct: 730 VEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYAKLISLLTAPVYEQA 789
Query: 2202 NDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRLIGNESKGEHVPGFCLPKKGV 2261
D P + ++ + +L L A E RL+ + G V
Sbjct: 790 VDGGPGLHKQVFHSLARCVAALSAACPQ---EAASTASRLVCDARSPHSSTGV-----KV 841
Query: 2262 TSILPVLREGVLTGSPEQKEEAA---KALGLV---IRLTSADALRPSVVSITGPLIRILG 2315
+ L + G + G Q+E A +ALG +R ++ AL + L
Sbjct: 842 LAFLSLAEVGQVAGPGHQRELKAVLLEALGSPSEDVRAAASYALGRVGAGSLPDFLPFLL 901
Query: 2316 DRFSWNVKAALLETLSL---LLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALG 2372
++ + L SL L A +LKP+ + + + + G R A+ +G
Sbjct: 902 EQIEAEPRRQYLLLHSLREALGAAQPDSLKPYAEDIWALLFQRCEGAEEGTRGVVAECIG 961
Query: 2373 KLISIHIKVDPLFTELLNGIR---AMEDPGVRDTMLQALRFVIQGAGAKVDAVIRKNIVS 2429
KL + V+P F LL +R A P R T++ A++F+I +D +++ I
Sbjct: 962 KL----VLVNPSF--LLPRLRKQLAAGRPHTRSTVITAVKFLISDQPHPIDPLLKSFIGE 1015
Query: 2430 LLLSMLGHDEDNTRISSA 2447
+ S+ D + R + A
Sbjct: 1016 FMESLQDPDLNVRRATLA 1033
Score = 35.8 bits (81), Expect = 0.58
Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 11/142 (7%)
Query: 1322 LMGSLAKH-LDKSDPKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQR 1380
LM L K + + + +V L+ L + +VQ CL PLV +KE I
Sbjct: 30 LMSELQKDSIQLDEDSERKVVKMLLRLLEDKNGEVQNLAVKCLGPLVVKVKEYQVETIVD 89
Query: 1381 LMQQLLESDKYAERKGAAYGLAGLVK-------GLGILSLKQQEMMAALTDAIQDKKNFR 1433
+ + SDK R A GL ++ G G+ + +++ LT AI +++
Sbjct: 90 TLCTNMRSDKEQLRDIAGIGLKTVLSELPPAATGSGLATNVCRKITGQLTSAIAQQEDVA 149
Query: 1434 RREGALFAFEMLCTMLGKLFEP 1455
+ L A ++L ML +L P
Sbjct: 150 VQ---LEALDILSDMLSRLGVP 168
Score = 34.3 bits (77), Expect = 1.7
Identities = 54/233 (23%), Positives = 93/233 (39%), Gaps = 33/233 (14%)
Query: 1495 VKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKV 1554
V LV+ +L L++ S R + G LL +A P L+ +P +V + L D
Sbjct: 434 VPLVVKALQRQLKDRSVRARQGCFSLLTELAGVLPGSLAEHMPVLVSGIIFSLAD----- 488
Query: 1555 QKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLA 1614
R S IR + LA LL T+P+ L LL
Sbjct: 489 --------RSSSSTIRM-DALAFLQGLLG--TEPAEAFHPHLPILLPP------------ 525
Query: 1615 LIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQK--DLAPYLPSVTPGLKASL--LDPV 1670
+M V +F + + + +++ ++ L + D PY+ ++ A L D
Sbjct: 526 -VMACVADSFYKIAAEALVVLQELVRALWPLHRPRMLDPEPYVGEMSAVTLARLRATDLD 584
Query: 1671 PEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEV 1723
EV+ + +G +V +G+ +DL P L+ L ++ + R A + L V
Sbjct: 585 QEVKERAISCMGHLVGHLGDRLGDDLEPTLLLLLDRLRNEITRLPAIKALTLV 637
>gi|21361794 TIP120 protein [Homo sapiens]
Length = 1230
Score = 40.8 bits (94), Expect = 0.018
Identities = 58/268 (21%), Positives = 98/268 (36%), Gaps = 13/268 (4%)
Query: 1539 IVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQT 1598
+V + ++L D + +VQ + L + S ++ ++ I L + + +
Sbjct: 49 VVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSI 108
Query: 1599 LLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKD-------- 1650
L T A S + + V + R T + + +L D
Sbjct: 109 GLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGL 168
Query: 1651 LAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSS 1710
L + PS+ L L P VR + ALG +V G F DL+ L+ L+ S
Sbjct: 169 LVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSM 228
Query: 1711 VDRSGAAQGLAEVMAGLG---VEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITF 1767
Q +A + G E LEK++P +V + D +R+ I F
Sbjct: 229 STTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDD--DELREYCIQAFESFVRRC 286
Query: 1768 GDKFTPYVGPIIPCILKALADENEFVRD 1795
+ P+V II LK L + + D
Sbjct: 287 PKEVYPHVSTIINICLKYLTYDPNYNYD 314
Score = 40.4 bits (93), Expect = 0.024
Identities = 153/763 (20%), Positives = 283/763 (37%), Gaps = 187/763 (24%)
Query: 1778 IIPCILKALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIR-FSSV 1836
++ ILK L D+N V++ A++ ++S E + ++ L + D ++R SS+
Sbjct: 49 VVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSI 108
Query: 1837 QL---LGDLLFHISG----------VTGKMTTETASEDDNFGTAQSNKAIITALGVERRN 1883
L +G+L SG +TG++T+ A ++D + AL +
Sbjct: 109 GLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDV-------SVQLEALDIM--- 158
Query: 1884 RVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRT 1943
++ RQ L +V+ P L +LP L L KRT
Sbjct: 159 ------------ADMLSRQGGL-----LVNFHPSILTCLLPQLTSPRLA------VRKRT 195
Query: 1944 IAARTLGDLVRKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEIMKSTSRDAVLYFS 2003
I A LG LV G + ++I L LSE+ K+ S +
Sbjct: 196 IIA--LGHLVMSCGNIVFVDLIEHL------------------LSELSKNDSMSTTRTYI 235
Query: 2004 ESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQA---LEDILPFLLK--QLDDEEVS 2058
+ + +R+A GH+ LE I+P ++K +DD+E+
Sbjct: 236 QCIAAISRQA-----------------------GHRIGEYLEKIIPLVVKFCNVDDDELR 272
Query: 2059 EFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVML 2118
E+ + + + PK P V+T + L + D +
Sbjct: 273 EYCIQAFESFVR---------RCPKEVYPHVSTIINICLKYLTYDPNYNY---------- 313
Query: 2119 ALKEKLGTPDEQLEMANCQAVILSVEDDTGHRIIIEDLLEATRSPEVGMRQAAAIILNIY 2178
D++ E N +DD G +D +R+AAA L+
Sbjct: 314 ---------DDEDEDENAMDADGGDDDDQGS----DDEYSDDDDMSWKVRRAAAKCLDAV 360
Query: 2179 CSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKL----------DAGNQ 2228
S +++ LI F + V + + A ++ K+ DA Q
Sbjct: 361 VSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQ 420
Query: 2229 LA------------LIEELHKEIRLIGNESKG----------EHVPGFCLPKKGVTSILP 2266
+++ LHK+++ +++ +PG +T +P
Sbjct: 421 GETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPG------ALTQHIP 474
Query: 2267 VLREGVL------TGSPEQKEEAAKALGLVIRLTSADALRPSVVSITGPLIRILGDRFSW 2320
VL G++ + S K +A L +++ S P V ++ P++ +GD F
Sbjct: 475 VLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYK 534
Query: 2321 NVKAALLETLSL------LLAKVGIALKPFLPQLQTTFTKALQ--DSNRGVRLKAADALG 2372
ALL T L L P++ L T K L+ D ++ V+ +A +G
Sbjct: 535 ITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMG 594
Query: 2373 KLISIHIKVDPLFTELLNGIR----AMEDPGVRDTMLQALRFVIQGAGAKVD-AVIRKNI 2427
++I D L ++L N ++ +++ R T ++AL +I G+ K+D +
Sbjct: 595 QIIC--NLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALT-LIAGSPLKIDLRPVLGEG 651
Query: 2428 VSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSAVLQQCL 2470
V +L S L ++ ++ + L L ++ +A++ L
Sbjct: 652 VPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVL 694
Score = 37.0 bits (84), Expect = 0.26
Identities = 51/207 (24%), Positives = 82/207 (39%), Gaps = 19/207 (9%)
Query: 2239 IRLIGNESKGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADA 2298
IRL+ S GE G + G + V+ E + S E K A+ ALG + +
Sbjct: 834 IRLLALLSLGE--VGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEY 891
Query: 2299 LRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIA-LKPFLPQLQTTFTKALQ 2357
L + IT R + LL +L +++ + LKP++ + K +
Sbjct: 892 LPFVLQEITSQPKR----------QYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCE 941
Query: 2358 DSNRGVRLKAADALGKLISIHIKVDP-LFTELLNGIRAMEDPGVRDTMLQALRFVIQGAG 2416
+ G R A+ LGKL I DP L G R +++ A++F I
Sbjct: 942 CAEEGTRNVVAECLGKLTLI----DPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHP 997
Query: 2417 AKVDAVIRKNIVSLLLSMLGHDEDNTR 2443
+D ++ KN + L L + N R
Sbjct: 998 QPIDPLL-KNCIGDFLKTLEDPDLNVR 1023
Score = 34.3 bits (77), Expect = 1.7
Identities = 66/304 (21%), Positives = 119/304 (39%), Gaps = 21/304 (6%)
Query: 1301 EFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQESVA 1360
E + ++ D + A + L K D S+ KV ++ KL L + +VQ
Sbjct: 13 EKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKL---LEDKNGEVQNLAV 69
Query: 1361 SCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLV-------KGLGILSL 1413
CL PLV +KE I + + SDK R ++ GL ++ G + +
Sbjct: 70 KCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAAN 129
Query: 1414 KQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQ 1473
+++ LT AI +++ + AL + + G L + +L LL
Sbjct: 130 VCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRL 189
Query: 1474 YVRE-AADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQL 1532
VR+ VMS + V L+ L + +S T ++ + A++ A ++
Sbjct: 190 AVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRI 249
Query: 1533 SSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRN------PEILAIAPVLLDALT 1586
L I+P V+ +V + + ++ S +R P + I + L LT
Sbjct: 250 GEYLEKIIPL---VVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLT 306
Query: 1587 -DPS 1589
DP+
Sbjct: 307 YDPN 310
>gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]
Length = 1119
Score = 40.4 bits (93), Expect = 0.024
Identities = 129/598 (21%), Positives = 217/598 (36%), Gaps = 76/598 (12%)
Query: 1885 VLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTI 1944
V+ L D + RQ + + P +L E +P L ++ LA + TI
Sbjct: 344 VVKALQRQLKDRSVRARQGCFSLLTELAGVLPGSLAEHMPVLVSGIIFSLADRSSSS-TI 402
Query: 1945 AARTLGDLVRKLGEK-----------ILPEIIPILEEGLRSQKSDER---QGVCIGLSEI 1990
L L LG + +LP ++ + + ++ Q + L +
Sbjct: 403 RMDALAFLQGLLGTEPAEAFHPHLPILLPPVMACVADSFYKIAAEALVVLQELVRALWPL 462
Query: 1991 MKSTSRDAVLYFSE-SLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLL 2049
+ D Y E S V AR D +EV+E A L +G + +D+ P LL
Sbjct: 463 HRPRMLDPEPYVGEMSAVTLARLRATDLDQEVKERAISCMGHLVGHLGDRLGDDLEPTLL 522
Query: 2050 KQLDDEEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPV--------------NTRVLA 2095
LD + + ++ AIK+ ++ +L P+ N R L
Sbjct: 523 LLLDRLR------NEITRLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKNQRALR 576
Query: 2096 FLSSVAGDALTRHLGVILP--AVMLALKEKLGTPDEQ-LEMANCQAVILSVEDDTGHRII 2152
+ A DAL + G+ LP AV L E +E + +A L+ +
Sbjct: 577 LATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQAQPASL 636
Query: 2153 IE-------DLLEATRSP--EVGMRQAAAIILNIYCSRSK--ADYTSHLRSLVSGLIRLF 2201
+E +LL RSP G+ AA L DY + L + +
Sbjct: 637 VEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYAKLISLLTAPVYEQA 696
Query: 2202 NDSSPVVLEESWDALNAITKKLDAGNQLALIEELHKEIRLIGNESKGEHVPGFCLPKKGV 2261
D P + ++ + +L L A E RL+ + G V
Sbjct: 697 VDGGPGLHKQVFHSLARCVAALSAACPQ---EAASTASRLVCDARSPHSSTGV-----KV 748
Query: 2262 TSILPVLREGVLTGSPEQKEEAA---KALGLV---IRLTSADALRPSVVSITGPLIRILG 2315
+ L + G + G Q+E A +ALG +R ++ AL + L
Sbjct: 749 LAFLSLAEVGQVAGPGHQRELKAVLLEALGSPSEDVRAAASYALGRVGAGSLPDFLPFLL 808
Query: 2316 DRFSWNVKAALLETLSL---LLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALG 2372
++ + L SL L A +LKP+ + + + + G R A+ +G
Sbjct: 809 EQIEAEPRRQYLLLHSLREALGAAQPDSLKPYAEDIWALLFQRCEGAEEGTRGVVAECIG 868
Query: 2373 KLISIHIKVDPLFTELLNGIR---AMEDPGVRDTMLQALRFVIQGAGAKVDAVIRKNI 2427
KL + V+P F LL +R A P R T++ A++F+I +D +++ I
Sbjct: 869 KL----VLVNPSF--LLPRLRKQLAAGRPHTRSTVITAVKFLISDQPHPIDPLLKSFI 920
Score = 34.3 bits (77), Expect = 1.7
Identities = 54/233 (23%), Positives = 93/233 (39%), Gaps = 33/233 (14%)
Query: 1495 VKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKV 1554
V LV+ +L L++ S R + G LL +A P L+ +P +V + L D
Sbjct: 341 VPLVVKALQRQLKDRSVRARQGCFSLLTELAGVLPGSLAEHMPVLVSGIIFSLAD----- 395
Query: 1555 QKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLA 1614
R S IR + LA LL T+P+ L LL
Sbjct: 396 --------RSSSSTIRM-DALAFLQGLLG--TEPAEAFHPHLPILLPP------------ 432
Query: 1615 LIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQK--DLAPYLPSVTPGLKASL--LDPV 1670
+M V +F + + + +++ ++ L + D PY+ ++ A L D
Sbjct: 433 -VMACVADSFYKIAAEALVVLQELVRALWPLHRPRMLDPEPYVGEMSAVTLARLRATDLD 491
Query: 1671 PEVRTVSAKALGAMVKGMGESCFEDLLPWLMETLTYEQSSVDRSGAAQGLAEV 1723
EV+ + +G +V +G+ +DL P L+ L ++ + R A + L V
Sbjct: 492 QEVKERAISCMGHLVGHLGDRLGDDLEPTLLLLLDRLRNEITRLPAIKALTLV 544
>gi|27477070 BTAF1 RNA polymerase II, B-TFIID transcription
factor-associated, 170kDa [Homo sapiens]
Length = 1849
Score = 40.0 bits (92), Expect = 0.031
Identities = 49/211 (23%), Positives = 88/211 (41%), Gaps = 22/211 (10%)
Query: 1468 FGD--GNQYVREAADDCAKA---VMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLG 1522
FGD ++ V + CA+ V+ +++ GV + LL L +E W + G LLG
Sbjct: 355 FGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLLTQEQWEVRHGG--LLG 412
Query: 1523 AMAYCAPKQ--LSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGS---VIRNPEILAI 1577
A +Q +++ LP ++ ++ E L D V+ +L + ++ ++ I
Sbjct: 413 IKYALAVRQDVINTLLPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESLVYLQTQKVPFI 472
Query: 1578 APVLLDAL--TDPSRKTQKCLQTLLDTKFVH-----FIDAPSLALIMPIVQRAFQDRSTD 1630
L DAL D + + TLL + + SL +++P V +
Sbjct: 473 INTLWDALLELDDLTASTNSIMTLLSSLLTYPQVQQCSIQQSLTVLVPRVWPFLHHTISS 532
Query: 1631 TRKMAAQIIGNMYSLTDQKD---LAPYLPSV 1658
R+ A + + + S DQ L P LP +
Sbjct: 533 VRRAALETLFTLLSTQDQNSSSWLIPILPDM 563
Score = 36.6 bits (83), Expect = 0.34
Identities = 64/286 (22%), Positives = 114/286 (39%), Gaps = 46/286 (16%)
Query: 1353 QQVQESVASCLPPLVPAIKEDAG----GMIQRLMQQLLESDK--YAERKGAAYGLAGLVK 1406
Q+ ++ S P A+K G ++ +L E+ K +R+GA + L +VK
Sbjct: 977 QKAAFAITSRRGPTPKAVKAQIADLPAGSSGNILVELDEAQKPYLVQRRGAEFALTTIVK 1036
Query: 1407 GLG-ILSLKQQEMMAALTDAIQDKKNFRRREG----------------ALFAFEMLCTML 1449
G +++K + A+ +++ + +G +L FE +
Sbjct: 1037 HFGGEMAVKLPHLWDAMVGPLRNTIDINNFDGKSLLDKGDSPAQELVNSLQVFETAAASM 1096
Query: 1450 GKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHG-----VKLVLPSLLA 1504
P +V LPHL +C + VR A C VMS ++ ++ VLP L
Sbjct: 1097 DSELHPLLVQHLPHLYMCLQYPSTAVRHMAARCV-GVMSKIATMETMNIFLEKVLP-WLG 1154
Query: 1505 ALEEESWRTKAGSVELLGAMAYCAPKQLS-SCLPNIVPKLTEVLTDSHVKVQKAGQQALR 1563
A+++ + G++E L C +QL +P IV + VL + A +
Sbjct: 1155 AIDDSV--KQEGAIEALA----CVMEQLDVGIVPYIVLLVVPVLGRMSDQTDSVRFMATQ 1208
Query: 1564 QIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFID 1609
++IR + A P DP + + +Q L K HF++
Sbjct: 1209 CFATLIRLMPLEAGIP-------DPPNMSAELIQ--LKAKERHFLE 1245
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 39.3 bits (90), Expect = 0.053
Identities = 40/132 (30%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 223 LLDFYMKNILMSKVKPPKYLL--DSCAPLLRYLSHSEFKDLIL----PTIQKSLLR--SP 274
L D K + + PK+L C LL Y + E K +IL P ++R S
Sbjct: 266 LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSY 324
Query: 275 ENVIETISSLLASVTLDLSQYAMDIVKG----LAGHLKSNSPRLMDEAVLALRNLARQCS 330
E ++ T S +L +++ S + G L HL SNSPRL+ + LRNL+ +
Sbjct: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVAT 384
Query: 331 DSSAMESLTKHL 342
+ES+ K L
Sbjct: 385 KQEGLESVLKIL 396
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 39.3 bits (90), Expect = 0.053
Identities = 40/132 (30%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 223 LLDFYMKNILMSKVKPPKYLL--DSCAPLLRYLSHSEFKDLIL----PTIQKSLLR--SP 274
L D K + + PK+L C LL Y + E K +IL P ++R S
Sbjct: 266 LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSY 324
Query: 275 ENVIETISSLLASVTLDLSQYAMDIVKG----LAGHLKSNSPRLMDEAVLALRNLARQCS 330
E ++ T S +L +++ S + G L HL SNSPRL+ + LRNL+ +
Sbjct: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVAT 384
Query: 331 DSSAMESLTKHL 342
+ES+ K L
Sbjct: 385 KQEGLESVLKIL 396
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 38.9 bits (89), Expect = 0.069
Identities = 32/163 (19%), Positives = 72/163 (44%), Gaps = 6/163 (3%)
Query: 2297 DALRPSVVSITGPLIRILGDRFSWNVKAALLETLSLLLAKVGIALKPFLPQLQTTFTKAL 2356
D P+V + L+RI D+ + +++ ++ + +G+ FLPQ+ TF +
Sbjct: 944 DEFYPAVSMVA--LMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVI 1001
Query: 2357 QDSNRGVRLKAADALGKLIS-IHIKVDPLFTELLNGIRA--MEDPGVRDTMLQALRFVIQ 2413
+ + +R LG L+S + + P E++ +R + + ++ T++ + ++
Sbjct: 1002 RVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVV 1061
Query: 2414 GAGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAF 2456
G + + ++ +L + HD RI S L + F
Sbjct: 1062 ALGGEFKLYL-PQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLF 1103
Score = 32.7 bits (73), Expect = 4.9
Identities = 50/248 (20%), Positives = 93/248 (37%), Gaps = 47/248 (18%)
Query: 1215 VLDALGR--VISESPPDQWEARCGLALALNKLSQYLDSSQVKPLFQFFVPDALNDRHPDV 1272
V D L + V+ + PD C LA + +L +Q + L FV ALND+ ++
Sbjct: 652 VADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHL--AQAENLQALFV--ALNDQVFEI 707
Query: 1273 RKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAV---RQSVVVLMGSLAKH 1329
R + A+ T+ N ++P + L + + + ++ ++G L +
Sbjct: 708 R----ELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSN 763
Query: 1330 LDKS-DPKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQRLMQQLLES 1388
+ P ++PI+ LI L P V + + + + + +G LE
Sbjct: 764 APRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSG----------LEM 813
Query: 1389 DKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAIQDKKNFRRREGALFAFEMLCTM 1448
K+ + E+ + D +QD +R+ AL+ L
Sbjct: 814 RKWVD-----------------------ELFIIIMDMLQDSSLLAKRQVALWTLGQLVAS 850
Query: 1449 LGKLFEPY 1456
G + EPY
Sbjct: 851 TGYVVEPY 858
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 38.5 bits (88), Expect = 0.090
Identities = 27/101 (26%), Positives = 49/101 (48%)
Query: 756 RLVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIK 815
R + EE + + EL + + QQ +++ R + +EQ E ++E +
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328
Query: 816 KKKGIKEEVQLTSKQKEMLQAQLDREAQVRRRLQELDGELE 856
+++ + E QL +Q+E + QL RE + RR Q+L E E
Sbjct: 329 EQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369
Score = 34.7 bits (78), Expect = 1.3
Identities = 22/83 (26%), Positives = 46/83 (55%), Gaps = 8/83 (9%)
Query: 779 IQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQK------- 831
++ +Q+ ++ +KRE ++Q+++ E +EE ++++ ++ E Q +Q+
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEE-RRQQQLRREQQERREQRLKREEEE 665
Query: 832 EMLQAQLDREAQVRRRLQELDGE 854
E L+ +L RE + RR QEL E
Sbjct: 666 ERLEQRLKREHEEERREQELAEE 688
Score = 32.7 bits (73), Expect = 4.9
Identities = 20/67 (29%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 783 QQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDREA 842
+Q+ ++ ++RE + +EQ + E +EE ++++ ++ E QL +Q+ + QL RE
Sbjct: 342 EQEERREQQLRREQEEER-REQQLRREQEEE-RREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 843 QVRRRLQ 849
Q+RR Q
Sbjct: 400 QLRREQQ 406
Score = 32.3 bits (72), Expect = 6.4
Identities = 23/100 (23%), Positives = 50/100 (50%), Gaps = 9/100 (9%)
Query: 760 REEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKE------- 812
R++ + E + + +++ +++ +R+ + +EQ+ +LE +E
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE 292
Query: 813 EIKKKKGIKEEVQLTSKQKEMLQAQLD--REAQVRRRLQE 850
E ++++ ++ E QL KQ+E + Q + RE Q RR QE
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
>gi|57863301 CLIP-associating protein 2 [Homo sapiens]
Length = 1506
Score = 38.5 bits (88), Expect = 0.090
Identities = 21/51 (41%), Positives = 28/51 (54%), Gaps = 3/51 (5%)
Query: 1430 KNFRRREGALFAFEMLCTMLGKLFEPYVVH-VLPHLLLCFGDGNQYVREAA 1479
KNFR REG + G +P V+ ++PHL + FGD N VR+AA
Sbjct: 139 KNFRSREGVCLCLIETLNIFGA--QPLVISKLIPHLCILFGDSNSQVRDAA 187
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 38.1 bits (87), Expect = 0.12
Identities = 40/173 (23%), Positives = 83/173 (47%), Gaps = 20/173 (11%)
Query: 706 LDQIIPRMTTQSP-LNQSSMNAMGSLSVLSPDRV---------LPQLISTITASV-QNPA 754
LD+ + R+T + L ++ A+G L DRV L Q + + S+ Q
Sbjct: 1034 LDESVARLTKEKKALQEAHQQALGDLQA-EEDRVSALTKAKLRLEQQVEDLECSLEQEKK 1092
Query: 755 LRLVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYS------FKEQIIEL 808
LR+ T ++ +L +S+ +AQ + +K+++ S EQ++
Sbjct: 1093 LRMDTERAKRKLEGDL-KLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGA 1151
Query: 809 ELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDRE-AQVRRRLQELDGELEAALG 860
+++++IK+ + EE++ + + +A+++++ A+ R L+EL LE A G
Sbjct: 1152 QMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGG 1204
Score = 32.3 bits (72), Expect = 6.4
Identities = 24/86 (27%), Positives = 43/86 (50%), Gaps = 5/86 (5%)
Query: 766 MQTPAGELYDKSIIQSAQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQ 825
+QT +GEL S + ++ I + + + A S +E + +L+EE K K + VQ
Sbjct: 1329 LQTESGEL---SRLLEEKECLISQLSRGKALAAQSLEE--LRRQLEEESKAKSALAHAVQ 1383
Query: 826 LTSKQKEMLQAQLDREAQVRRRLQEL 851
++L+ Q + EA+ + LQ L
Sbjct: 1384 ALRHDCDLLREQHEEEAEAQAELQRL 1409
>gi|110815815 centlein isoform 1 [Homo sapiens]
Length = 1406
Score = 38.1 bits (87), Expect = 0.12
Identities = 21/69 (30%), Positives = 39/69 (56%), Gaps = 1/69 (1%)
Query: 783 QQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDREA 842
Q+ ++K + K +F++ +IE + E+ + K +QL++KQ E++Q +D
Sbjct: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD-IT 325
Query: 843 QVRRRLQEL 851
VR+ LQEL
Sbjct: 326 LVRKELQEL 334
>gi|167555106 centlein isoform 2 [Homo sapiens]
Length = 391
Score = 38.1 bits (87), Expect = 0.12
Identities = 21/69 (30%), Positives = 39/69 (56%), Gaps = 1/69 (1%)
Query: 783 QQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDREA 842
Q+ ++K + K +F++ +IE + E+ + K +QL++KQ E++Q +D
Sbjct: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD-IT 325
Query: 843 QVRRRLQEL 851
VR+ LQEL
Sbjct: 326 LVRKELQEL 334
>gi|156766050 AHNAK nucleoprotein 2 [Homo sapiens]
Length = 5795
Score = 37.4 bits (85), Expect = 0.20
Identities = 73/341 (21%), Positives = 130/341 (38%), Gaps = 47/341 (13%)
Query: 624 VTDAGEVTEAGKAYVPPRVLQEALCVISGVPGLKGDVTDTEQLAQEMLIISHHPSLVAVQ 683
V+ G+ EA PP+V + +P ++GD+ T+ Q + + V VQ
Sbjct: 2165 VSAPGKSIEASVDVSPPKVEADM-----SLPSMQGDLKTTDLSIQPL------SADVKVQ 2213
Query: 684 SGLWPALLARMKIDPEAFITRHLDQI------IPRMTTQSP---LNQSSMNAMG-SLSVL 733
+G L + E + HL ++ +P++ + P + ++ + V
Sbjct: 2214 AGQVDVKLLEGPVPEEVGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDLKDPKVEVT 2273
Query: 734 SPDRVLPQLISTITASVQNPALRLVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMK 793
+PD + + ++ V+ P +L M L DK + +A+ K K
Sbjct: 2274 APD--VEVSLPSVEVDVKAPGAKLDGARLEGDMS-----LADKDV--TAKDSKFKMPKFK 2324
Query: 794 RENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDREAQVRRRLQELDG 853
+ S + IE K ++ +V L S Q ++ L +Q
Sbjct: 2325 MLSFGVSALGKSIEASADVSALK---VEADVSLPSMQGDLKTTDLS--------VQPPSA 2373
Query: 854 ELEAALGLLDIILAKNP----SGLTQYIPVLVDSFLPLLKSPLAAPRI--KNPFLSLAAC 907
+LE G +D+ L + P +GL ++P L + K L P+I K P L L
Sbjct: 2374 DLEVQAGQVDVKLPEGPVPEGAGLKGHLPKLQMPSFKMPKVDLKGPQIDVKGPKLDLKGP 2433
Query: 908 VMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVK 948
+ V + + P LD +W + +LSVA K
Sbjct: 2434 KTDVMAPDVEVSQPSVEVDVEAPGAKLDGAWLEGDLSVADK 2474
>gi|148352331 cell division cycle 10 isoform 1 [Homo sapiens]
Length = 437
Score = 37.0 bits (84), Expect = 0.26
Identities = 22/83 (26%), Positives = 46/83 (55%), Gaps = 1/83 (1%)
Query: 782 AQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQ-KEMLQAQLDR 840
AQ + ++ ++ + K EQ+ E+++KE+++K K + E+Q +Q K+ L+AQ
Sbjct: 337 AQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKE 396
Query: 841 EAQVRRRLQELDGELEAALGLLD 863
+ RR+ ++ EA +L+
Sbjct: 397 LEEKRRQFEDEKANWEAQQRILE 419
>gi|148352329 cell division cycle 10 isoform 2 [Homo sapiens]
Length = 436
Score = 37.0 bits (84), Expect = 0.26
Identities = 22/83 (26%), Positives = 46/83 (55%), Gaps = 1/83 (1%)
Query: 782 AQQDSIKKANMKRENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQ-KEMLQAQLDR 840
AQ + ++ ++ + K EQ+ E+++KE+++K K + E+Q +Q K+ L+AQ
Sbjct: 336 AQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKE 395
Query: 841 EAQVRRRLQELDGELEAALGLLD 863
+ RR+ ++ EA +L+
Sbjct: 396 LEEKRRQFEDEKANWEAQQRILE 418
>gi|54112117 splicing factor 3b, subunit 1 isoform 1 [Homo sapiens]
Length = 1304
Score = 37.0 bits (84), Expect = 0.26
Identities = 59/280 (21%), Positives = 114/280 (40%), Gaps = 36/280 (12%)
Query: 1309 DASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIA-ALSTPSQQVQESVASCLPPLV 1367
DA Y V+L+ L + D ++K IV K++ T + LPP
Sbjct: 758 DAEYANYYTREVMLI--LIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILPPFF 815
Query: 1368 PAIKEDAGGMIQRLMQQLLESD-KYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTDAI 1426
+ + +R +QL+++ + A + GAA ++ +V L + + ++M+ + I
Sbjct: 816 KHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKI 875
Query: 1427 QD---------KKNFRRREGALFAFEMLCT--------------MLGKLFEPYVVHVLPH 1463
K + +G L+AF+ T LGK +PY+ +
Sbjct: 876 MGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICGT 935
Query: 1464 LLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEE---ESWRTKAGSVEL 1520
+L + + VR+ A D + + ++ L L E E + GS+
Sbjct: 936 VLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSI-- 993
Query: 1521 LGAMA----YCAPKQLSSCLPNIVPKLTEVLTDSHVKVQK 1556
LGA+ +++ + +++P+LT +L + H KVQ+
Sbjct: 994 LGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQE 1033
>gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]
Length = 639
Score = 37.0 bits (84), Expect = 0.26
Identities = 33/120 (27%), Positives = 53/120 (44%), Gaps = 13/120 (10%)
Query: 746 ITASVQNPALRLVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANM---------KREN 796
+T ++ RL + EF Q E K + +++ + + K N
Sbjct: 132 VTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATN 191
Query: 797 KAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDREAQVRRRLQELDGELE 856
KA ++ EL LK E +K + K E +L +++K LQ EAQV ++L E D E E
Sbjct: 192 KAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQT----EAQVEKQLSEFDIERE 247
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 37.0 bits (84), Expect = 0.26
Identities = 49/192 (25%), Positives = 78/192 (40%), Gaps = 29/192 (15%)
Query: 1486 VMSNLSAHG--------VKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLP 1537
VM NL H ++ +LP+L + +V L + +Q+ +
Sbjct: 223 VMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVID 282
Query: 1538 N-IVPKLTEVLTDSHVKVQKAGQQALRQIGS----------VIRNPEILAIAPVLLDALT 1586
+ IVP L +L+ VKVQ A ALR +G+ V+ N + L+ P L LT
Sbjct: 283 SGIVPHLVPLLSHQEVKVQTA---ALRAVGNIVTGTDEQTQVVLNCDALSHFPAL---LT 336
Query: 1587 DPSRKTQKCLQTLLDTKFV---HFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMY 1643
P K K L + A A ++P++ T+K AA I N+
Sbjct: 337 HPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNL- 395
Query: 1644 SLTDQKDLAPYL 1655
+++ +KD YL
Sbjct: 396 TISGRKDQVAYL 407
Score = 33.9 bits (76), Expect = 2.2
Identities = 28/118 (23%), Positives = 52/118 (44%), Gaps = 11/118 (9%)
Query: 2347 QLQTTFTKAL----QDSNRGVRLKAADALGKLISI--HIKVDPLFTE-----LLNGIRAM 2395
++Q T +A+ N+G++L A A KL+S + +D L L++ +
Sbjct: 67 RVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERD 126
Query: 2396 EDPGVRDTMLQALRFVIQGAGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGEL 2453
++P ++ AL + G + AV++ N V L L +L N + LG +
Sbjct: 127 DNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNI 184
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 36.6 bits (83), Expect = 0.34
Identities = 91/404 (22%), Positives = 161/404 (39%), Gaps = 48/404 (11%)
Query: 792 MKRENKAYSFKEQIIEL---ELKEE----IKKKKGI-----KEEVQLTSKQK---EMLQA 836
++++ +SF E+ E+ EL+EE +K K + K+E++ SK K E L
Sbjct: 843 IEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHL 902
Query: 837 QLDREAQVRRRLQELDGELEAALGLLDI--ILAKNPSGLTQYIPVLVDSFLPL------L 888
Q V+ + D + L++ ++ K+ + L + + V L L L
Sbjct: 903 QRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDL 962
Query: 889 KSPLAAPRIKNPFLSLAACVMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVK 948
L + FL+ +K+L V+LR + E +++ + + S +
Sbjct: 963 SEQLKQKHGEISFLN-------EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1015
Query: 949 RAVMLLHTHTITSRVGKGEPGAAPLSAPAFSLVFPFLKMVLTEMPHHSE-EEEEWMAQIL 1007
+ +L T+TSR +G S S + K+ M E ++E+ + L
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075
Query: 1008 QILTVQAQLRASPNTPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLTTLC 1067
+T ++ LRA T P D+ EL + L RLQ+ A +L
Sbjct: 1076 PSVTKESSLRA---TQPSENDKLQKELNVLKSEQNDL---------RLQMEAQRICLSLV 1123
Query: 1068 ASSSGDDGCAFAEQEEVDVLLCALQSPCASVRETVLRGLMELHMV-LPAPDTDEKNGLNL 1126
S+ D + E E+ D LC+L+ +E ++ L ++H + L T E
Sbjct: 1124 YSTHVDQVREYMENEK-DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGK 1182
Query: 1127 LRRLWVVKFDK--EEEIRKLAERLWSMMGLDLQPDL-CSLLIDD 1167
L + K K EE + L S++G P L C + +D
Sbjct: 1183 PLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAED 1226
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 36.6 bits (83), Expect = 0.34
Identities = 91/404 (22%), Positives = 161/404 (39%), Gaps = 48/404 (11%)
Query: 792 MKRENKAYSFKEQIIEL---ELKEE----IKKKKGI-----KEEVQLTSKQK---EMLQA 836
++++ +SF E+ E+ EL+EE +K K + K+E++ SK K E L
Sbjct: 843 IEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHL 902
Query: 837 QLDREAQVRRRLQELDGELEAALGLLDI--ILAKNPSGLTQYIPVLVDSFLPL------L 888
Q V+ + D + L++ ++ K+ + L + + V L L L
Sbjct: 903 QRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDL 962
Query: 889 KSPLAAPRIKNPFLSLAACVMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVK 948
L + FL+ +K+L V+LR + E +++ + + S +
Sbjct: 963 SEQLKQKHGEISFLN-------EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1015
Query: 949 RAVMLLHTHTITSRVGKGEPGAAPLSAPAFSLVFPFLKMVLTEMPHHSE-EEEEWMAQIL 1007
+ +L T+TSR +G S S + K+ M E ++E+ + L
Sbjct: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHL 1075
Query: 1008 QILTVQAQLRASPNTPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLTTLC 1067
+T ++ LRA T P D+ EL + L RLQ+ A +L
Sbjct: 1076 PSVTKESSLRA---TQPSENDKLQKELNVLKSEQNDL---------RLQMEAQRICLSLV 1123
Query: 1068 ASSSGDDGCAFAEQEEVDVLLCALQSPCASVRETVLRGLMELHMV-LPAPDTDEKNGLNL 1126
S+ D + E E+ D LC+L+ +E ++ L ++H + L T E
Sbjct: 1124 YSTHVDQVREYMENEK-DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGK 1182
Query: 1127 LRRLWVVKFDK--EEEIRKLAERLWSMMGLDLQPDL-CSLLIDD 1167
L + K K EE + L S++G P L C + +D
Sbjct: 1183 PLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAED 1226
>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) isoform
1 [Homo sapiens]
Length = 897
Score = 36.2 bits (82), Expect = 0.44
Identities = 31/121 (25%), Positives = 51/121 (42%), Gaps = 8/121 (6%)
Query: 1478 AADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLP 1537
A D A L H +LP L L W K + +LGA+A + + LP
Sbjct: 379 ALDVLANVFREELLPH----LLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLP 434
Query: 1538 NIVPKLTEVLTDSHVKVQKAGQQAL-RQIGSVIRNPEILAIAPV---LLDALTDPSRKTQ 1593
++P L + L+D V+ L R V+ P + + P+ LL + D +++ Q
Sbjct: 435 ELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQ 494
Query: 1594 K 1594
+
Sbjct: 495 E 495
Score = 33.9 bits (76), Expect = 2.2
Identities = 36/136 (26%), Positives = 57/136 (41%), Gaps = 7/136 (5%)
Query: 1921 EILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKI---LPEIIPILEEGLRSQKS 1977
E+LP L LL G L + LG + + + LPE+IP L + L +K+
Sbjct: 390 ELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKA 449
Query: 1978 DERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIG 2037
R C LS + L+ K + D + V+EAA F +T+
Sbjct: 450 LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAF----ATLE 505
Query: 2038 HQALEDILPFLLKQLD 2053
+A +++P+L LD
Sbjct: 506 EEACTELVPYLSYILD 521
>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) isoform
3 [Homo sapiens]
Length = 887
Score = 36.2 bits (82), Expect = 0.44
Identities = 31/121 (25%), Positives = 51/121 (42%), Gaps = 8/121 (6%)
Query: 1478 AADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLP 1537
A D A L H +LP L L W K + +LGA+A + + LP
Sbjct: 379 ALDVLANVFREELLPH----LLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLP 434
Query: 1538 NIVPKLTEVLTDSHVKVQKAGQQAL-RQIGSVIRNPEILAIAPV---LLDALTDPSRKTQ 1593
++P L + L+D V+ L R V+ P + + P+ LL + D +++ Q
Sbjct: 435 ELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQ 494
Query: 1594 K 1594
+
Sbjct: 495 E 495
Score = 33.9 bits (76), Expect = 2.2
Identities = 36/136 (26%), Positives = 57/136 (41%), Gaps = 7/136 (5%)
Query: 1921 EILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKI---LPEIIPILEEGLRSQKS 1977
E+LP L LL G L + LG + + + LPE+IP L + L +K+
Sbjct: 390 ELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKA 449
Query: 1978 DERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIG 2037
R C LS + L+ K + D + V+EAA F +T+
Sbjct: 450 LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAF----ATLE 505
Query: 2038 HQALEDILPFLLKQLD 2053
+A +++P+L LD
Sbjct: 506 EEACTELVPYLSYILD 521
>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform 2
[Homo sapiens]
Length = 887
Score = 36.2 bits (82), Expect = 0.44
Identities = 31/121 (25%), Positives = 51/121 (42%), Gaps = 8/121 (6%)
Query: 1478 AADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLP 1537
A D A L H +LP L L W K + +LGA+A + + LP
Sbjct: 379 ALDVLANVFREELLPH----LLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLP 434
Query: 1538 NIVPKLTEVLTDSHVKVQKAGQQAL-RQIGSVIRNPEILAIAPV---LLDALTDPSRKTQ 1593
++P L + L+D V+ L R V+ P + + P+ LL + D +++ Q
Sbjct: 435 ELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQ 494
Query: 1594 K 1594
+
Sbjct: 495 E 495
Score = 33.9 bits (76), Expect = 2.2
Identities = 36/136 (26%), Positives = 57/136 (41%), Gaps = 7/136 (5%)
Query: 1921 EILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKI---LPEIIPILEEGLRSQKS 1977
E+LP L LL G L + LG + + + LPE+IP L + L +K+
Sbjct: 390 ELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKA 449
Query: 1978 DERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIG 2037
R C LS + L+ K + D + V+EAA F +T+
Sbjct: 450 LVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAF----ATLE 505
Query: 2038 HQALEDILPFLLKQLD 2053
+A +++P+L LD
Sbjct: 506 EEACTELVPYLSYILD 521
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,329,381
Number of Sequences: 37866
Number of extensions: 3967560
Number of successful extensions: 13817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 101
Number of HSP's that attempted gapping in prelim test: 13294
Number of HSP's gapped (non-prelim): 611
length of query: 2671
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2551
effective length of database: 13,703,598
effective search space: 34957878498
effective search space used: 34957878498
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.