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Search of human proteins with 52486251
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]
(752 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens] 1528 0.0
gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens] 1476 0.0
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 115 1e-25
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 114 4e-25
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 114 4e-25
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 114 4e-25
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 112 1e-24
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 112 1e-24
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 112 1e-24
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 112 1e-24
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 112 1e-24
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 110 5e-24
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 102 1e-21
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 100 6e-21
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 100 8e-21
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 94 6e-19
gi|30348954 mindbomb homolog 1 [Homo sapiens] 94 6e-19
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 93 1e-18
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 91 4e-18
gi|21264330 mindbomb homolog 2 [Homo sapiens] 87 4e-17
gi|48525351 patatin-like phospholipase domain containing 8 [Homo... 86 2e-16
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 85 2e-16
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 84 5e-16
gi|134133226 protein expressed in prostate, ovary, testis, and p... 82 2e-15
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 81 3e-15
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 80 5e-15
gi|52856434 POTE ankyrin domain family, member G [Homo sapiens] 80 7e-15
gi|224282147 prostate-specific P704P [Homo sapiens] 80 7e-15
gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens] 80 7e-15
gi|153791352 prostate, ovary, testis expressed protein on chromo... 80 7e-15
>gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]
Length = 752
Score = 1528 bits (3955), Expect = 0.0
Identities = 752/752 (100%), Positives = 752/752 (100%)
Query: 1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV 60
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV
Sbjct: 1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV 60
Query: 61 NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW 120
NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW
Sbjct: 61 NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW 120
Query: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD
Sbjct: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
Query: 181 VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL
Sbjct: 181 VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
Query: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA
Sbjct: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
Query: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK
Sbjct: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
Query: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEK 420
DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEK
Sbjct: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEK 420
Query: 421 RTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSM 480
RTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSM
Sbjct: 421 RTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSM 480
Query: 481 AYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPA 540
AYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPA
Sbjct: 481 AYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPA 540
Query: 541 ELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGG 600
ELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGG
Sbjct: 541 ELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGG 600
Query: 601 LLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNP 660
LLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNP
Sbjct: 601 LLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNP 660
Query: 661 WELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVS 720
WELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVS
Sbjct: 661 WELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVS 720
Query: 721 DTVLVNALWETEVYIYEHREEFQKLIQLLLSP 752
DTVLVNALWETEVYIYEHREEFQKLIQLLLSP
Sbjct: 721 DTVLVNALWETEVYIYEHREEFQKLIQLLLSP 752
>gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]
Length = 806
Score = 1476 bits (3820), Expect = 0.0
Identities = 741/806 (91%), Positives = 744/806 (92%), Gaps = 54/806 (6%)
Query: 1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV 60
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV
Sbjct: 1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV 60
Query: 61 NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW 120
NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW
Sbjct: 61 NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW 120
Query: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD
Sbjct: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
Query: 181 VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL
Sbjct: 181 VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
Query: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA
Sbjct: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
Query: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK
Sbjct: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
Query: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQL----------------------- 397
DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR +
Sbjct: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG 420
Query: 398 ----------QDLMHISRARKP---------------------AFILGSMRDEKRTHDHL 426
+ RA+ P AFILGSMRDEKRTHDHL
Sbjct: 421 VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL 480
Query: 427 LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM 486
LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM
Sbjct: 481 LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM 540
Query: 487 YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR 546
YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR
Sbjct: 541 YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR 600
Query: 547 NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP 606
NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP
Sbjct: 601 NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP 660
Query: 607 TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT 666
TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT
Sbjct: 661 TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT 720
Query: 667 VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN 726
VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN
Sbjct: 721 VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN 780
Query: 727 ALWETEVYIYEHREEFQKLIQLLLSP 752
ALWETEVYIYEHREEFQKLIQLLLSP
Sbjct: 781 ALWETEVYIYEHREEFQKLIQLLLSP 806
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 115 bits (289), Expect = 1e-25
Identities = 81/275 (29%), Positives = 134/275 (48%), Gaps = 8/275 (2%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
H++ LG + + A G TPLHL+ R+G ++ L+ + + +T
Sbjct: 504 HISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH-GASLSITT 562
Query: 184 YKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCN 243
KG T H A + +V LL + + A + GLTPLH+A Q++ +LL
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKS-ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
Query: 244 ARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEM 299
A + NGY P+H A K +Q A ++ + + R G + +H A + +M
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA--NAVTRQGIASVHLAAQEGHVDM 679
Query: 300 ARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMS 359
+LL R NVN ++ +G T LH+A +R + A VL+ GA+ DA+ + G TPLH+
Sbjct: 680 VSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCH 739
Query: 360 KDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
N++++ L+ A+V+ G TP A++ G
Sbjct: 740 YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQG 774
Score = 112 bits (281), Expect = 1e-24
Identities = 82/280 (29%), Positives = 138/280 (49%), Gaps = 16/280 (5%)
Query: 124 HLAVELG----IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQM 179
H+A +G + + HH + N G T LH+A R G E++ LVQ Q+
Sbjct: 438 HVAAFMGHVNIVSQLMHHGASPNTTNV----RGETALHMAARSGQAEVVRYLVQD-GAQV 492
Query: 180 DVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
+ +T H + + + ++Q L + A N G TPLHL+ + G +++ L
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQG-ASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Query: 240 LLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK--- 295
L A +I G+ P+H A K+ + A +++ +S + G +PLH A
Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP--DAAGKSGLTPLHVAAHYD 609
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N ++A +LL +G + ++ + G T LH+A +N+ D A LL +GA+A+A G +H
Sbjct: 610 NQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
LA + +V+M+ L+ A V+ N G TP LA++ R
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDR 709
Score = 103 bits (256), Expect = 8e-22
Identities = 71/254 (27%), Positives = 124/254 (48%), Gaps = 8/254 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ +G TPLH R G +++ L+ + T G + H A QGD+ +QLL
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK-NGLSPLHMATQGDHLNCVQLLL 354
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ V ++ V N LT LH+A G ++ +VLL A N NG+ P+H A K ++
Sbjct: 355 QHNVP-VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRI 413
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
E+++ +S G +P+H A + + L+ G + N+T+ G TALH
Sbjct: 414 KVMELLLKHGAS--IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALH 471
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+A + + L+ GA +A+ + TPLH++ ++++ L+ GA +
Sbjct: 472 MAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
Query: 383 GETPTFLASKIGRQ 396
G TP L+++ G +
Sbjct: 532 GYTPLHLSAREGHE 545
Score = 102 bits (253), Expect = 2e-21
Identities = 74/262 (28%), Positives = 124/262 (47%), Gaps = 12/262 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G E++ EL+Q +D KG T H A ++V+++L N
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQR-EANVDAATKKGNTALHIASLAGQAEVVKVLVTN 129
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + G TPL++A Q E+V+ LL A ++ +G+ P+ A++
Sbjct: 130 G-ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQV 188
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+++ D+ + LH A + + A +LL+ N + S +G T LH+A
Sbjct: 189 VSLLLENDTKG------KVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL A D + TPLH+A + N M+K L+ GA++D G
Sbjct: 243 AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL 302
Query: 385 TPTFLASKIGRQLQDLMHISRA 406
TP ++ G + M + RA
Sbjct: 303 TPLHCGARSGHEQVVEMLLDRA 324
Score = 99.4 bits (246), Expect = 1e-20
Identities = 74/252 (29%), Positives = 126/252 (50%), Gaps = 8/252 (3%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
E++ G TPLH+A G+ + L+ +D T T H A + N+ +++LL
Sbjct: 231 ESKSGFTPLHIAAHYGNINVATLLLNRA-AAVDFTARNDITPLHVASKRGNANMVKLL-L 288
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
+ A ++ GLTPLH + G +++V +LL A NG P+H A +
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 267 CAEMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHV 323
C ++++ + + Y + LH A + ++A++LL + N N+ + G T LH+
Sbjct: 349 CVQLLLQ-HNVPVDDVTNDY-LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A +NR +LL HGA+ A E G TP+H+A +V ++ L+ GA +T N G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 384 ETPTFLASKIGR 395
ET +A++ G+
Sbjct: 467 ETALHMAARSGQ 478
Score = 90.1 bits (222), Expect = 7e-18
Identities = 69/260 (26%), Positives = 120/260 (46%), Gaps = 8/260 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
T LH+A G ++ L+ + G T H A + + +V++LL ++ A +
Sbjct: 369 TALHVAAHCGHYKVAKVLLDK-KANPNAKALNGFTPLHIACKKNRIKVMELLLKHG-ASI 426
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMII 272
V GLTP+H+A +G +V L+ A N G +H A + Q ++
Sbjct: 427 QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLV 486
Query: 273 SMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D +Q+ +K + +PLH + A++ + LL++G + N+ +++G T LH++
Sbjct: 487 Q-DGAQVEAK-AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGH 544
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
D A LL HGA+ + G TPLH+A +E+ L+ A D G TP +
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 390 ASKIGRQLQDLMHISRARKP 409
A+ Q L+ + + P
Sbjct: 605 AAHYDNQKVALLLLDQGASP 624
Score = 78.2 bits (191), Expect = 3e-14
Identities = 71/278 (25%), Positives = 119/278 (42%), Gaps = 9/278 (3%)
Query: 106 VLQHLTDL-IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGD 164
+L H L I ++ H+A + G E + S + A + G TPLH+A +
Sbjct: 551 LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN 610
Query: 165 GEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPL 224
++ + L+ G T H A + + + L A N V QG+ +
Sbjct: 611 QKVALLLLDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG-ADANAVTRQGIASV 668
Query: 225 HLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKD 283
HLA Q G +MV +LL NA N+ +G P+H A + + AE++++ +
Sbjct: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV--DAQ 726
Query: 284 PRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHG 340
+ G +PLH N ++ LL+ VN+ + G T LH A + VLL +
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
Query: 341 ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
A+ + +GNT L +A + ++ L + E T
Sbjct: 787 ASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMT 824
Score = 73.9 bits (180), Expect = 5e-13
Identities = 47/149 (31%), Positives = 84/149 (56%), Gaps = 8/149 (5%)
Query: 287 GASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A + E+ LL+R NV++ + GNTALH+A + + + VL+T+GAN
Sbjct: 74 GLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR-QLQDLM- 401
+A+ ++G TPL++A ++++E++K L+ GA + G TP +A + G Q+ L+
Sbjct: 134 NAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193
Query: 402 ---HISRARKPAFILGSMRDEKRTHDHLL 427
+ R PA + + +D+ + LL
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLL 222
Score = 60.5 bits (145), Expect = 6e-09
Identities = 33/99 (33%), Positives = 51/99 (51%)
Query: 294 AKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTP 353
A + E A +K G ++N + G ALH+A + LL AN DA + GNT
Sbjct: 51 AGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTA 110
Query: 354 LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
LH+A E++K L+ GA V+ + G TP ++A++
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQ 149
Score = 34.7 bits (78), Expect = 0.33
Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 1/98 (1%)
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
E R KR + S A + L A + A+ + +G + + ++G LHLA
Sbjct: 23 EKKRKHRKRSRDRKKKSDANASYLRAA-RAGHLEKALDYIKNGVDINICNQNGLNALHLA 81
Query: 358 MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
+ +VE++ L+ A VD G T +AS G+
Sbjct: 82 SKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 114 bits (284), Expect = 4e-25
Identities = 79/253 (31%), Positives = 130/253 (51%), Gaps = 10/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH++ R+G ++ L++ + KG T H A + + V +LL
Sbjct: 504 AATTNGYTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+ A + GLTPLH+A Q++ +LL A + NGY P+H A K +Q
Sbjct: 563 QRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621
Query: 266 GCAEMIISMDS-SQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTAL 321
A +++ + + I +K G +PLH A + +M +LL +G N++ ++ +G T+L
Sbjct: 622 QIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678
Query: 322 HVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
H+A ++ + A +L HGA+ DA + G TPL +A NV+M+ L+ GA V+
Sbjct: 679 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 738
Query: 382 FGETPTFLASKIG 394
G TP A++ G
Sbjct: 739 NGYTPLHQAAQQG 751
Score = 99.4 bits (246), Expect = 1e-20
Identities = 73/253 (28%), Positives = 124/253 (49%), Gaps = 8/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ +G TPLH A R G ++ VEL+ + G + H A QGD+ + ++ L
Sbjct: 273 AKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 331
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ A ++ V LT LH+A G + ++LL A N NG+ P+H A K ++
Sbjct: 332 QHK-APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 390
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
E+++ +S + G +P+H A + + +LL+ G + + T+ G TALH
Sbjct: 391 KVMELLVKYGASIQAITES--GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 448
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+A + + LL +GA DAR TPLH+A E+++ L+ A D
Sbjct: 449 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 508
Query: 383 GETPTFLASKIGR 395
G TP ++++ G+
Sbjct: 509 GYTPLHISAREGQ 521
Score = 94.4 bits (233), Expect = 4e-19
Identities = 69/257 (26%), Positives = 119/257 (46%), Gaps = 18/257 (7%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G ++ EL+ + +D KG T H A ++V+++L +
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 98
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + G TPL++A Q ++V+ LL A + +G+ P+ A++
Sbjct: 99 G-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQA 157
Query: 268 AEMIISMDSS----------QIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAG 317
+++ D+ D + A L NA++ ++ VN T+ +G
Sbjct: 158 VAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM-----VNRTTESG 212
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
T LH+A + A +LL GA D +G TPLH+A + N M+K L+ G ++D
Sbjct: 213 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 272
Query: 378 TPNDFGETPTFLASKIG 394
G TP A++ G
Sbjct: 273 AKTRDGLTPLHCAARSG 289
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/248 (28%), Positives = 122/248 (49%), Gaps = 8/248 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A ++G+ +V+L+ Q+D G T H A + + QV++LL
Sbjct: 245 GITPLHVASKRGNTN-MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEM 270
L + N GL+PLH+A Q E V+ LL A + + + +H A ++
Sbjct: 304 LLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 362
Query: 271 IISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ D + G +PLH A ++ +L+K G ++ + + +G T +HVA
Sbjct: 363 LL--DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
+ ++LL +GA+ D G T LH+A VE+++ L+ GA VD +TP
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
Query: 388 FLASKIGR 395
+AS++G+
Sbjct: 481 HIASRLGK 488
Score = 93.2 bits (230), Expect = 8e-19
Identities = 75/235 (31%), Positives = 113/235 (48%), Gaps = 12/235 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
+ G TPLH+A + ++ + L++ T G T H A + + Q+ L N
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTL-LNY 630
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCA 268
A N V QG+TPLHLA Q G +MV +LL A ++ +G +H A + + A
Sbjct: 631 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 690
Query: 269 EMIISMDSSQ-IHSKDPRYGASPL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHV 323
+++ + Q H+K G +PL H+ N +M LLK+G NVN+ + G T LH
Sbjct: 691 DILTKHGADQDAHTK---LGYTPLIVACHYG-NVKMVNFLLKQGANVNAKTKNGYTPLHQ 746
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
A + VLL HGA +A +GNT L +A + ++ L V EV T
Sbjct: 747 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 801
Score = 90.9 bits (224), Expect = 4e-18
Identities = 80/307 (26%), Positives = 138/307 (44%), Gaps = 23/307 (7%)
Query: 116 NHPSWSVAHLAVELG----IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVEL 171
N + HLA + G ++E + A ++G T LH+A G E++ L
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT----KKGNTALHIASLAGQAEVVKVL 95
Query: 172 VQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLG 231
V+ ++ G T + A Q ++ V++ L N A + G TPL +A Q G
Sbjct: 96 VKE-GANINAQSQNGFTPLYMAAQENHIDVVKYLLENG-ANQSTATEDGFTPLAVALQQG 153
Query: 232 KQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMD------SSQIHSKDPR 285
+ V +LL + + + P +H A + A +++ D S + ++
Sbjct: 154 HNQAVAILLENDTKGKVRLP---ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 210
Query: 286 YGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGAN 342
G +PLH A N +A +LL RG V+ T+ G T LHVA R + +LL G
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 270
Query: 343 ADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMH 402
DA+ G TPLH A + ++++ L+ GA + G +P +A++ G ++ + H
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQ-GDHVECVKH 329
Query: 403 ISRARKP 409
+ + + P
Sbjct: 330 LLQHKAP 336
Score = 82.4 bits (202), Expect = 1e-15
Identities = 70/261 (26%), Positives = 118/261 (45%), Gaps = 39/261 (14%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+AC+K +++ LV+Y + +T+ G T H A + ++ LL +N A
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITE-SGLTPIHVAAFMGHLNIVLLLLQNG-A 434
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMI 271
+ N +G T LH+A + G+ E+VR LL NG + + + Q
Sbjct: 435 SPDVTNIRGETALHMAARAGQVEVVRCLLR----------NGALVDARAREEQ------- 477
Query: 272 ISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALHVAVMRN 328
+PLH A E+ ++LL+ + ++ ++ G T LH++
Sbjct: 478 -----------------TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
Query: 329 RFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTF 388
+ D A VLL GA + G TPLH+A ++++ K L+ A D+ G TP
Sbjct: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580
Query: 389 LASKIGRQLQDLMHISRARKP 409
+A+ Q L+ + + P
Sbjct: 581 VAAHYDNQKVALLLLEKGASP 601
Score = 72.0 bits (175), Expect = 2e-12
Identities = 45/149 (30%), Positives = 82/149 (55%), Gaps = 8/149 (5%)
Query: 287 GASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A + + + LL RG +V+S + GNTALH+A + + + VL+ GAN
Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQ-----LQ 398
+A+ ++G TPL++A +++++++K L+ GA T + G TP +A + G L
Sbjct: 103 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Query: 399 DLMHISRARKPAFILGSMRDEKRTHDHLL 427
+ + R PA + + +D+ ++ LL
Sbjct: 163 ENDTKGKVRLPALHIAARKDDTKSAALLL 191
Score = 57.4 bits (137), Expect = 5e-08
Identities = 30/99 (30%), Positives = 51/99 (51%)
Query: 294 AKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTP 353
A N + LK G ++N+ + G ALH+A LL G++ D+ + GNT
Sbjct: 20 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 79
Query: 354 LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
LH+A E++K L+ GA ++ + G TP ++A++
Sbjct: 80 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 118
Score = 35.0 bits (79), Expect = 0.26
Identities = 21/81 (25%), Positives = 37/81 (45%)
Query: 315 SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
S N + A D + L G + + ++G LHLA + +V +++ L+ G+
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 375 EVDTPNDFGETPTFLASKIGR 395
VD+ G T +AS G+
Sbjct: 68 SVDSATKKGNTALHIASLAGQ 88
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 114 bits (284), Expect = 4e-25
Identities = 79/253 (31%), Positives = 130/253 (51%), Gaps = 10/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH++ R+G ++ L++ + KG T H A + + V +LL
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+ A + GLTPLH+A Q++ +LL A + NGY P+H A K +Q
Sbjct: 584 QRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
Query: 266 GCAEMIISMDS-SQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTAL 321
A +++ + + I +K G +PLH A + +M +LL +G N++ ++ +G T+L
Sbjct: 643 QIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Query: 322 HVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
H+A ++ + A +L HGA+ DA + G TPL +A NV+M+ L+ GA V+
Sbjct: 700 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 759
Query: 382 FGETPTFLASKIG 394
G TP A++ G
Sbjct: 760 NGYTPLHQAAQQG 772
Score = 99.4 bits (246), Expect = 1e-20
Identities = 73/253 (28%), Positives = 124/253 (49%), Gaps = 8/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ +G TPLH A R G ++ VEL+ + G + H A QGD+ + ++ L
Sbjct: 294 AKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ A ++ V LT LH+A G + ++LL A N NG+ P+H A K ++
Sbjct: 353 QHK-APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
E+++ +S + G +P+H A + + +LL+ G + + T+ G TALH
Sbjct: 412 KVMELLVKYGASIQAITES--GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 469
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+A + + LL +GA DAR TPLH+A E+++ L+ A D
Sbjct: 470 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 529
Query: 383 GETPTFLASKIGR 395
G TP ++++ G+
Sbjct: 530 GYTPLHISAREGQ 542
Score = 94.4 bits (233), Expect = 4e-19
Identities = 69/257 (26%), Positives = 119/257 (46%), Gaps = 18/257 (7%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G ++ EL+ + +D KG T H A ++V+++L +
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + G TPL++A Q ++V+ LL A + +G+ P+ A++
Sbjct: 120 G-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQA 178
Query: 268 AEMIISMDSS----------QIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAG 317
+++ D+ D + A L NA++ ++ VN T+ +G
Sbjct: 179 VAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM-----VNRTTESG 233
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
T LH+A + A +LL GA D +G TPLH+A + N M+K L+ G ++D
Sbjct: 234 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 378 TPNDFGETPTFLASKIG 394
G TP A++ G
Sbjct: 294 AKTRDGLTPLHCAARSG 310
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/248 (28%), Positives = 122/248 (49%), Gaps = 8/248 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A ++G+ +V+L+ Q+D G T H A + + QV++LL
Sbjct: 266 GITPLHVASKRGNTN-MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEM 270
L + N GL+PLH+A Q E V+ LL A + + + +H A ++
Sbjct: 325 LLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 271 IISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ D + G +PLH A ++ +L+K G ++ + + +G T +HVA
Sbjct: 384 LL--DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
+ ++LL +GA+ D G T LH+A VE+++ L+ GA VD +TP
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 388 FLASKIGR 395
+AS++G+
Sbjct: 502 HIASRLGK 509
Score = 93.2 bits (230), Expect = 8e-19
Identities = 75/235 (31%), Positives = 113/235 (48%), Gaps = 12/235 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
+ G TPLH+A + ++ + L++ T G T H A + + Q+ L N
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTL-LNY 651
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCA 268
A N V QG+TPLHLA Q G +MV +LL A ++ +G +H A + + A
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 269 EMIISMDSSQ-IHSKDPRYGASPL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHV 323
+++ + Q H+K G +PL H+ N +M LLK+G NVN+ + G T LH
Sbjct: 712 DILTKHGADQDAHTK---LGYTPLIVACHYG-NVKMVNFLLKQGANVNAKTKNGYTPLHQ 767
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
A + VLL HGA +A +GNT L +A + ++ L V EV T
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 90.9 bits (224), Expect = 4e-18
Identities = 80/307 (26%), Positives = 138/307 (44%), Gaps = 23/307 (7%)
Query: 116 NHPSWSVAHLAVELG----IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVEL 171
N + HLA + G ++E + A ++G T LH+A G E++ L
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT----KKGNTALHIASLAGQAEVVKVL 116
Query: 172 VQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLG 231
V+ ++ G T + A Q ++ V++ L N A + G TPL +A Q G
Sbjct: 117 VKE-GANINAQSQNGFTPLYMAAQENHIDVVKYLLENG-ANQSTATEDGFTPLAVALQQG 174
Query: 232 KQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMD------SSQIHSKDPR 285
+ V +LL + + + P +H A + A +++ D S + ++
Sbjct: 175 HNQAVAILLENDTKGKVRLP---ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
Query: 286 YGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGAN 342
G +PLH A N +A +LL RG V+ T+ G T LHVA R + +LL G
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 343 ADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMH 402
DA+ G TPLH A + ++++ L+ GA + G +P +A++ G ++ + H
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQ-GDHVECVKH 350
Query: 403 ISRARKP 409
+ + + P
Sbjct: 351 LLQHKAP 357
Score = 82.4 bits (202), Expect = 1e-15
Identities = 70/261 (26%), Positives = 118/261 (45%), Gaps = 39/261 (14%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+AC+K +++ LV+Y + +T+ G T H A + ++ LL +N A
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITE-SGLTPIHVAAFMGHLNIVLLLLQNG-A 455
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMI 271
+ N +G T LH+A + G+ E+VR LL NG + + + Q
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLR----------NGALVDARAREEQ------- 498
Query: 272 ISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALHVAVMRN 328
+PLH A E+ ++LL+ + ++ ++ G T LH++
Sbjct: 499 -----------------TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 329 RFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTF 388
+ D A VLL GA + G TPLH+A ++++ K L+ A D+ G TP
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
Query: 389 LASKIGRQLQDLMHISRARKP 409
+A+ Q L+ + + P
Sbjct: 602 VAAHYDNQKVALLLLEKGASP 622
Score = 72.0 bits (175), Expect = 2e-12
Identities = 45/149 (30%), Positives = 82/149 (55%), Gaps = 8/149 (5%)
Query: 287 GASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A + + + LL RG +V+S + GNTALH+A + + + VL+ GAN
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQ-----LQ 398
+A+ ++G TPL++A +++++++K L+ GA T + G TP +A + G L
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 399 DLMHISRARKPAFILGSMRDEKRTHDHLL 427
+ + R PA + + +D+ ++ LL
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLL 212
Score = 57.4 bits (137), Expect = 5e-08
Identities = 30/99 (30%), Positives = 51/99 (51%)
Query: 294 AKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTP 353
A N + LK G ++N+ + G ALH+A LL G++ D+ + GNT
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
Query: 354 LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
LH+A E++K L+ GA ++ + G TP ++A++
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 139
Score = 35.0 bits (79), Expect = 0.26
Identities = 21/81 (25%), Positives = 37/81 (45%)
Query: 315 SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
S N + A D + L G + + ++G LHLA + +V +++ L+ G+
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 375 EVDTPNDFGETPTFLASKIGR 395
VD+ G T +AS G+
Sbjct: 89 SVDSATKKGNTALHIASLAGQ 109
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 114 bits (284), Expect = 4e-25
Identities = 79/253 (31%), Positives = 130/253 (51%), Gaps = 10/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH++ R+G ++ L++ + KG T H A + + V +LL
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+ A + GLTPLH+A Q++ +LL A + NGY P+H A K +Q
Sbjct: 584 QRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
Query: 266 GCAEMIISMDS-SQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTAL 321
A +++ + + I +K G +PLH A + +M +LL +G N++ ++ +G T+L
Sbjct: 643 QIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Query: 322 HVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
H+A ++ + A +L HGA+ DA + G TPL +A NV+M+ L+ GA V+
Sbjct: 700 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 759
Query: 382 FGETPTFLASKIG 394
G TP A++ G
Sbjct: 760 NGYTPLHQAAQQG 772
Score = 99.4 bits (246), Expect = 1e-20
Identities = 73/253 (28%), Positives = 124/253 (49%), Gaps = 8/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ +G TPLH A R G ++ VEL+ + G + H A QGD+ + ++ L
Sbjct: 294 AKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ A ++ V LT LH+A G + ++LL A N NG+ P+H A K ++
Sbjct: 353 QHK-APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
E+++ +S + G +P+H A + + +LL+ G + + T+ G TALH
Sbjct: 412 KVMELLVKYGASIQAITES--GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 469
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+A + + LL +GA DAR TPLH+A E+++ L+ A D
Sbjct: 470 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 529
Query: 383 GETPTFLASKIGR 395
G TP ++++ G+
Sbjct: 530 GYTPLHISAREGQ 542
Score = 94.4 bits (233), Expect = 4e-19
Identities = 69/257 (26%), Positives = 119/257 (46%), Gaps = 18/257 (7%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G ++ EL+ + +D KG T H A ++V+++L +
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + G TPL++A Q ++V+ LL A + +G+ P+ A++
Sbjct: 120 G-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQA 178
Query: 268 AEMIISMDSS----------QIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAG 317
+++ D+ D + A L NA++ ++ VN T+ +G
Sbjct: 179 VAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM-----VNRTTESG 233
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
T LH+A + A +LL GA D +G TPLH+A + N M+K L+ G ++D
Sbjct: 234 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 378 TPNDFGETPTFLASKIG 394
G TP A++ G
Sbjct: 294 AKTRDGLTPLHCAARSG 310
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/248 (28%), Positives = 122/248 (49%), Gaps = 8/248 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A ++G+ +V+L+ Q+D G T H A + + QV++LL
Sbjct: 266 GITPLHVASKRGNTN-MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEM 270
L + N GL+PLH+A Q E V+ LL A + + + +H A ++
Sbjct: 325 LLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 271 IISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ D + G +PLH A ++ +L+K G ++ + + +G T +HVA
Sbjct: 384 LL--DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
+ ++LL +GA+ D G T LH+A VE+++ L+ GA VD +TP
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 388 FLASKIGR 395
+AS++G+
Sbjct: 502 HIASRLGK 509
Score = 93.2 bits (230), Expect = 8e-19
Identities = 75/235 (31%), Positives = 113/235 (48%), Gaps = 12/235 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
+ G TPLH+A + ++ + L++ T G T H A + + Q+ L N
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTL-LNY 651
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCA 268
A N V QG+TPLHLA Q G +MV +LL A ++ +G +H A + + A
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 269 EMIISMDSSQ-IHSKDPRYGASPL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHV 323
+++ + Q H+K G +PL H+ N +M LLK+G NVN+ + G T LH
Sbjct: 712 DILTKHGADQDAHTK---LGYTPLIVACHYG-NVKMVNFLLKQGANVNAKTKNGYTPLHQ 767
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
A + VLL HGA +A +GNT L +A + ++ L V EV T
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 90.9 bits (224), Expect = 4e-18
Identities = 80/307 (26%), Positives = 138/307 (44%), Gaps = 23/307 (7%)
Query: 116 NHPSWSVAHLAVELG----IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVEL 171
N + HLA + G ++E + A ++G T LH+A G E++ L
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT----KKGNTALHIASLAGQAEVVKVL 116
Query: 172 VQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLG 231
V+ ++ G T + A Q ++ V++ L N A + G TPL +A Q G
Sbjct: 117 VKE-GANINAQSQNGFTPLYMAAQENHIDVVKYLLENG-ANQSTATEDGFTPLAVALQQG 174
Query: 232 KQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMD------SSQIHSKDPR 285
+ V +LL + + + P +H A + A +++ D S + ++
Sbjct: 175 HNQAVAILLENDTKGKVRLP---ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
Query: 286 YGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGAN 342
G +PLH A N +A +LL RG V+ T+ G T LHVA R + +LL G
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQ 291
Query: 343 ADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMH 402
DA+ G TPLH A + ++++ L+ GA + G +P +A++ G ++ + H
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQ-GDHVECVKH 350
Query: 403 ISRARKP 409
+ + + P
Sbjct: 351 LLQHKAP 357
Score = 82.4 bits (202), Expect = 1e-15
Identities = 70/261 (26%), Positives = 118/261 (45%), Gaps = 39/261 (14%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+AC+K +++ LV+Y + +T+ G T H A + ++ LL +N A
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITE-SGLTPIHVAAFMGHLNIVLLLLQNG-A 455
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMI 271
+ N +G T LH+A + G+ E+VR LL NG + + + Q
Sbjct: 456 SPDVTNIRGETALHMAARAGQVEVVRCLLR----------NGALVDARAREEQ------- 498
Query: 272 ISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALHVAVMRN 328
+PLH A E+ ++LL+ + ++ ++ G T LH++
Sbjct: 499 -----------------TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 329 RFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTF 388
+ D A VLL GA + G TPLH+A ++++ K L+ A D+ G TP
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
Query: 389 LASKIGRQLQDLMHISRARKP 409
+A+ Q L+ + + P
Sbjct: 602 VAAHYDNQKVALLLLEKGASP 622
Score = 72.0 bits (175), Expect = 2e-12
Identities = 45/149 (30%), Positives = 82/149 (55%), Gaps = 8/149 (5%)
Query: 287 GASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A + + + LL RG +V+S + GNTALH+A + + + VL+ GAN
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQ-----LQ 398
+A+ ++G TPL++A +++++++K L+ GA T + G TP +A + G L
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 399 DLMHISRARKPAFILGSMRDEKRTHDHLL 427
+ + R PA + + +D+ ++ LL
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLL 212
Score = 57.4 bits (137), Expect = 5e-08
Identities = 30/99 (30%), Positives = 51/99 (51%)
Query: 294 AKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTP 353
A N + LK G ++N+ + G ALH+A LL G++ D+ + GNT
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
Query: 354 LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
LH+A E++K L+ GA ++ + G TP ++A++
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ 139
Score = 35.0 bits (79), Expect = 0.26
Identities = 21/81 (25%), Positives = 37/81 (45%)
Query: 315 SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
S N + A D + L G + + ++G LHLA + +V +++ L+ G+
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 375 EVDTPNDFGETPTFLASKIGR 395
VD+ G T +AS G+
Sbjct: 89 SVDSATKKGNTALHIASLAGQ 109
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 490
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 491 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 550 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 607
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 608 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 667
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 668 GVTPLHLAAQEG 679
Score = 109 bits (272), Expect = 1e-23
Identities = 79/245 (32%), Positives = 126/245 (51%), Gaps = 8/245 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 472 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 529
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 590 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 647
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 707
Query: 390 ASKIG 394
++ G
Sbjct: 708 VAQEG 712
Score = 109 bits (272), Expect = 1e-23
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A R+G E ++ L++ +Q +T KG T H A + +V +LL A
Sbjct: 536 GHTPLHIAAREGHVETVLALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERD-A 593
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEM 270
N GLTPLH+A ++V++LL + NGY P+H A K +Q A
Sbjct: 594 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ S + + G +PLH A +AEM +LL + N N + +G T LH+
Sbjct: 654 LLQYGGSA--NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 711
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
A VL+ HG DA G TPLH+A N++++K L+ A+V+ G +P
Sbjct: 712 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 771
Query: 388 FLASKIG 394
A++ G
Sbjct: 772 HQAAQQG 778
Score = 97.1 bits (240), Expect = 5e-20
Identities = 72/250 (28%), Positives = 124/250 (49%), Gaps = 12/250 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 132
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 192
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 193 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 246
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 247 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 306
Query: 385 TPTFLASKIG 394
TP A++ G
Sbjct: 307 TPLHCAARNG 316
Score = 96.3 bits (238), Expect = 9e-20
Identities = 74/250 (29%), Positives = 122/250 (48%), Gaps = 10/250 (4%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 567 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 626 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 681
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 801
Query: 385 TPTFLASKIG 394
TP +A ++G
Sbjct: 802 TPLAIAKRLG 811
Score = 91.3 bits (225), Expect = 3e-18
Identities = 80/276 (28%), Positives = 120/276 (43%), Gaps = 41/276 (14%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 210 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 267
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 326
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 327 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 385
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 445
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
++ ++K L+ GA + N ETP +A++ G
Sbjct: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 481
Score = 86.3 bits (212), Expect = 1e-16
Identities = 78/283 (27%), Positives = 123/283 (43%), Gaps = 37/283 (13%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 359
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 360 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 418
Query: 267 CAEMII----SMDSSQIHSKDPRYGAS---------------------------PLHWAK 295
E+++ S+D+ P + AS PLH A
Sbjct: 419 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 478
Query: 296 NA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
A E+A+ LL+ VN+ + T LH A + +LL + AN + G+T
Sbjct: 479 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 538
Query: 353 PLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
PLH+A + +VE + AL+ A G TP +A+K G+
Sbjct: 539 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 581
Score = 67.4 bits (163), Expect = 5e-11
Identities = 44/150 (29%), Positives = 79/150 (52%), Gaps = 10/150 (6%)
Query: 287 GASPLHWAKNAEMARM---LLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A +M LL + + +T+ GNTALH+A + + + L+ +GAN
Sbjct: 78 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 137
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHI 403
+A+ + G TPL++A ++++E++K L+ GA + + G TP +A + G + + H+
Sbjct: 138 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE-NVVAHL 196
Query: 404 ------SRARKPAFILGSMRDEKRTHDHLL 427
+ R PA + + D+ RT LL
Sbjct: 197 INYGTKGKVRLPALHIAARNDDTRTAAVLL 226
Score = 57.8 bits (138), Expect = 4e-08
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 35/179 (19%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
AE+ +G TPLHLA ++G E +V L+ ++ + G T H Q + V +L
Sbjct: 663 AESVQGVTPLHLAAQEGHAE-MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 721
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ V ++ G TPLH+A G ++V+ LL A N GY P+H A +Q+
Sbjct: 722 KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA---AQQ 777
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVA 324
G + ++ +LLK G + N SS G T L +A
Sbjct: 778 G-----------------------------HTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/97 (26%), Positives = 48/97 (49%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 57 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 116
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
+A E+++ L+ +GA V+ + G TP ++A++
Sbjct: 117 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 153
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH+A G+ +++ L+Q+ ++ G + H A Q ++ ++ LL
Sbjct: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
+N A N+V++ G TPL +A +LG + VL
Sbjct: 788 KNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 458 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 517 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 635 GVTPLHLAAQEG 646
Score = 109 bits (272), Expect = 1e-23
Identities = 79/245 (32%), Positives = 126/245 (51%), Gaps = 8/245 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 496
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 557 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 390 ASKIG 394
++ G
Sbjct: 675 VAQEG 679
Score = 109 bits (272), Expect = 1e-23
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A R+G E ++ L++ +Q +T KG T H A + +V +LL A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERD-A 560
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEM 270
N GLTPLH+A ++V++LL + NGY P+H A K +Q A
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ S + + G +PLH A +AEM +LL + N N + +G T LH+
Sbjct: 621 LLQYGGSA--NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 678
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
A VL+ HG DA G TPLH+A N++++K L+ A+V+ G +P
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738
Query: 388 FLASKIG 394
A++ G
Sbjct: 739 HQAAQQG 745
Score = 97.1 bits (240), Expect = 5e-20
Identities = 72/250 (28%), Positives = 124/250 (49%), Gaps = 12/250 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 99
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 160 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 385 TPTFLASKIG 394
TP A++ G
Sbjct: 274 TPLHCAARNG 283
Score = 96.3 bits (238), Expect = 9e-20
Identities = 74/250 (29%), Positives = 122/250 (48%), Gaps = 10/250 (4%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 534 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 593 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 648
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768
Query: 385 TPTFLASKIG 394
TP +A ++G
Sbjct: 769 TPLAIAKRLG 778
Score = 91.3 bits (225), Expect = 3e-18
Identities = 80/276 (28%), Positives = 120/276 (43%), Gaps = 41/276 (14%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 177 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 293
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 294 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
++ ++K L+ GA + N ETP +A++ G
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Score = 86.3 bits (212), Expect = 1e-16
Identities = 78/283 (27%), Positives = 123/283 (43%), Gaps = 37/283 (13%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 327 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 267 CAEMII----SMDSSQIHSKDPRYGAS---------------------------PLHWAK 295
E+++ S+D+ P + AS PLH A
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 296 NA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
A E+A+ LL+ VN+ + T LH A + +LL + AN + G+T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 353 PLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
PLH+A + +VE + AL+ A G TP +A+K G+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Score = 67.4 bits (163), Expect = 5e-11
Identities = 44/150 (29%), Positives = 79/150 (52%), Gaps = 10/150 (6%)
Query: 287 GASPLHWAKNAEMARM---LLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A +M LL + + +T+ GNTALH+A + + + L+ +GAN
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHI 403
+A+ + G TPL++A ++++E++K L+ GA + + G TP +A + G + + H+
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE-NVVAHL 163
Query: 404 ------SRARKPAFILGSMRDEKRTHDHLL 427
+ R PA + + D+ RT LL
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLL 193
Score = 57.8 bits (138), Expect = 4e-08
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 35/179 (19%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
AE+ +G TPLHLA ++G E +V L+ ++ + G T H Q + V +L
Sbjct: 630 AESVQGVTPLHLAAQEGHAE-MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ V ++ G TPLH+A G ++V+ LL A N GY P+H A +Q+
Sbjct: 689 KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA---AQQ 744
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVA 324
G + ++ +LLK G + N SS G T L +A
Sbjct: 745 G-----------------------------HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/97 (26%), Positives = 48/97 (49%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 83
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
+A E+++ L+ +GA V+ + G TP ++A++
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH+A G+ +++ L+Q+ ++ G + H A Q ++ ++ LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
+N A N+V++ G TPL +A +LG + VL
Sbjct: 755 KNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 458 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 517 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 635 GVTPLHLAAQEG 646
Score = 109 bits (272), Expect = 1e-23
Identities = 79/245 (32%), Positives = 126/245 (51%), Gaps = 8/245 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 496
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 557 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 390 ASKIG 394
++ G
Sbjct: 675 VAQEG 679
Score = 109 bits (272), Expect = 1e-23
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A R+G E ++ L++ +Q +T KG T H A + +V +LL A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERD-A 560
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEM 270
N GLTPLH+A ++V++LL + NGY P+H A K +Q A
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ S + + G +PLH A +AEM +LL + N N + +G T LH+
Sbjct: 621 LLQYGGSA--NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 678
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
A VL+ HG DA G TPLH+A N++++K L+ A+V+ G +P
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738
Query: 388 FLASKIG 394
A++ G
Sbjct: 739 HQAAQQG 745
Score = 97.1 bits (240), Expect = 5e-20
Identities = 72/250 (28%), Positives = 124/250 (49%), Gaps = 12/250 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 99
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 160 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 385 TPTFLASKIG 394
TP A++ G
Sbjct: 274 TPLHCAARNG 283
Score = 96.3 bits (238), Expect = 9e-20
Identities = 74/250 (29%), Positives = 122/250 (48%), Gaps = 10/250 (4%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 534 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 593 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 648
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768
Query: 385 TPTFLASKIG 394
TP +A ++G
Sbjct: 769 TPLAIAKRLG 778
Score = 91.3 bits (225), Expect = 3e-18
Identities = 80/276 (28%), Positives = 120/276 (43%), Gaps = 41/276 (14%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 177 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 293
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 294 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
++ ++K L+ GA + N ETP +A++ G
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Score = 86.3 bits (212), Expect = 1e-16
Identities = 78/283 (27%), Positives = 123/283 (43%), Gaps = 37/283 (13%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 327 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 267 CAEMII----SMDSSQIHSKDPRYGAS---------------------------PLHWAK 295
E+++ S+D+ P + AS PLH A
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 296 NA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
A E+A+ LL+ VN+ + T LH A + +LL + AN + G+T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 353 PLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
PLH+A + +VE + AL+ A G TP +A+K G+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Score = 67.4 bits (163), Expect = 5e-11
Identities = 44/150 (29%), Positives = 79/150 (52%), Gaps = 10/150 (6%)
Query: 287 GASPLHWAKNAEMARM---LLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A +M LL + + +T+ GNTALH+A + + + L+ +GAN
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHI 403
+A+ + G TPL++A ++++E++K L+ GA + + G TP +A + G + + H+
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE-NVVAHL 163
Query: 404 ------SRARKPAFILGSMRDEKRTHDHLL 427
+ R PA + + D+ RT LL
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLL 193
Score = 57.8 bits (138), Expect = 4e-08
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 35/179 (19%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
AE+ +G TPLHLA ++G E +V L+ ++ + G T H Q + V +L
Sbjct: 630 AESVQGVTPLHLAAQEGHAE-MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ V ++ G TPLH+A G ++V+ LL A N GY P+H A +Q+
Sbjct: 689 KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA---AQQ 744
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVA 324
G + ++ +LLK G + N SS G T L +A
Sbjct: 745 G-----------------------------HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/97 (26%), Positives = 48/97 (49%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 83
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
+A E+++ L+ +GA V+ + G TP ++A++
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH+A G+ +++ L+Q+ ++ G + H A Q ++ ++ LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
+N A N+V++ G TPL +A +LG + VL
Sbjct: 755 KNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 458 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 517 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 635 GVTPLHLAAQEG 646
Score = 109 bits (272), Expect = 1e-23
Identities = 79/245 (32%), Positives = 126/245 (51%), Gaps = 8/245 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 496
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 557 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 390 ASKIG 394
++ G
Sbjct: 675 VAQEG 679
Score = 109 bits (272), Expect = 1e-23
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A R+G E ++ L++ +Q +T KG T H A + +V +LL A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERD-A 560
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEM 270
N GLTPLH+A ++V++LL + NGY P+H A K +Q A
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ S + + G +PLH A +AEM +LL + N N + +G T LH+
Sbjct: 621 LLQYGGSA--NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 678
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
A VL+ HG DA G TPLH+A N++++K L+ A+V+ G +P
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738
Query: 388 FLASKIG 394
A++ G
Sbjct: 739 HQAAQQG 745
Score = 97.1 bits (240), Expect = 5e-20
Identities = 72/250 (28%), Positives = 124/250 (49%), Gaps = 12/250 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 99
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 160 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 385 TPTFLASKIG 394
TP A++ G
Sbjct: 274 TPLHCAARNG 283
Score = 96.3 bits (238), Expect = 9e-20
Identities = 74/250 (29%), Positives = 122/250 (48%), Gaps = 10/250 (4%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 534 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 593 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 648
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768
Query: 385 TPTFLASKIG 394
TP +A ++G
Sbjct: 769 TPLAIAKRLG 778
Score = 91.3 bits (225), Expect = 3e-18
Identities = 80/276 (28%), Positives = 120/276 (43%), Gaps = 41/276 (14%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 177 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 293
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 294 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
++ ++K L+ GA + N ETP +A++ G
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Score = 86.3 bits (212), Expect = 1e-16
Identities = 78/283 (27%), Positives = 123/283 (43%), Gaps = 37/283 (13%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 327 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 267 CAEMII----SMDSSQIHSKDPRYGAS---------------------------PLHWAK 295
E+++ S+D+ P + AS PLH A
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 296 NA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
A E+A+ LL+ VN+ + T LH A + +LL + AN + G+T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 353 PLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
PLH+A + +VE + AL+ A G TP +A+K G+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Score = 67.4 bits (163), Expect = 5e-11
Identities = 44/150 (29%), Positives = 79/150 (52%), Gaps = 10/150 (6%)
Query: 287 GASPLHWAKNAEMARM---LLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A +M LL + + +T+ GNTALH+A + + + L+ +GAN
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHI 403
+A+ + G TPL++A ++++E++K L+ GA + + G TP +A + G + + H+
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE-NVVAHL 163
Query: 404 ------SRARKPAFILGSMRDEKRTHDHLL 427
+ R PA + + D+ RT LL
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLL 193
Score = 57.8 bits (138), Expect = 4e-08
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 35/179 (19%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
AE+ +G TPLHLA ++G E +V L+ ++ + G T H Q + V +L
Sbjct: 630 AESVQGVTPLHLAAQEGHAE-MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ V ++ G TPLH+A G ++V+ LL A N GY P+H A +Q+
Sbjct: 689 KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA---AQQ 744
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVA 324
G + ++ +LLK G + N SS G T L +A
Sbjct: 745 G-----------------------------HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/97 (26%), Positives = 48/97 (49%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 83
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
+A E+++ L+ +GA V+ + G TP ++A++
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH+A G+ +++ L+Q+ ++ G + H A Q ++ ++ LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
+N A N+V++ G TPL +A +LG + VL
Sbjct: 755 KNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 458 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 517 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 635 GVTPLHLAAQEG 646
Score = 109 bits (272), Expect = 1e-23
Identities = 79/245 (32%), Positives = 126/245 (51%), Gaps = 8/245 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 496
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 557 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 390 ASKIG 394
++ G
Sbjct: 675 VAQEG 679
Score = 109 bits (272), Expect = 1e-23
Identities = 80/247 (32%), Positives = 122/247 (49%), Gaps = 8/247 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A R+G E ++ L++ +Q +T KG T H A + +V +LL A
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERD-A 560
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEM 270
N GLTPLH+A ++V++LL + NGY P+H A K +Q A
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ S + + G +PLH A +AEM +LL + N N + +G T LH+
Sbjct: 621 LLQYGGSA--NAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQE 678
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
A VL+ HG DA G TPLH+A N++++K L+ A+V+ G +P
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738
Query: 388 FLASKIG 394
A++ G
Sbjct: 739 HQAAQQG 745
Score = 97.1 bits (240), Expect = 5e-20
Identities = 72/250 (28%), Positives = 124/250 (49%), Gaps = 12/250 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 99
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 160 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 385 TPTFLASKIG 394
TP A++ G
Sbjct: 274 TPLHCAARNG 283
Score = 96.3 bits (238), Expect = 9e-20
Identities = 74/250 (29%), Positives = 122/250 (48%), Gaps = 10/250 (4%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 534 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 593 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 648
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768
Query: 385 TPTFLASKIG 394
TP +A ++G
Sbjct: 769 TPLAIAKRLG 778
Score = 91.3 bits (225), Expect = 3e-18
Identities = 80/276 (28%), Positives = 120/276 (43%), Gaps = 41/276 (14%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 177 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 293
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 294 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
++ ++K L+ GA + N ETP +A++ G
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Score = 86.3 bits (212), Expect = 1e-16
Identities = 78/283 (27%), Positives = 123/283 (43%), Gaps = 37/283 (13%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 327 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 267 CAEMII----SMDSSQIHSKDPRYGAS---------------------------PLHWAK 295
E+++ S+D+ P + AS PLH A
Sbjct: 386 VMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA 445
Query: 296 NA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
A E+A+ LL+ VN+ + T LH A + +LL + AN + G+T
Sbjct: 446 RAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 353 PLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
PLH+A + +VE + AL+ A G TP +A+K G+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGK 548
Score = 67.4 bits (163), Expect = 5e-11
Identities = 44/150 (29%), Positives = 79/150 (52%), Gaps = 10/150 (6%)
Query: 287 GASPLHWAKNAEMARM---LLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
G + LH A +M LL + + +T+ GNTALH+A + + + L+ +GAN
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHI 403
+A+ + G TPL++A ++++E++K L+ GA + + G TP +A + G + + H+
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE-NVVAHL 163
Query: 404 ------SRARKPAFILGSMRDEKRTHDHLL 427
+ R PA + + D+ RT LL
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLL 193
Score = 57.8 bits (138), Expect = 4e-08
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 35/179 (19%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
AE+ +G TPLHLA ++G E +V L+ ++ + G T H Q + V +L
Sbjct: 630 AESVQGVTPLHLAAQEGHAE-MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ V ++ G TPLH+A G ++V+ LL A N GY P+H A +Q+
Sbjct: 689 KHGVM-VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA---AQQ 744
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVA 324
G + ++ +LLK G + N SS G T L +A
Sbjct: 745 G-----------------------------HTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/97 (26%), Positives = 48/97 (49%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 83
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
+A E+++ L+ +GA V+ + G TP ++A++
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH+A G+ +++ L+Q+ ++ G + H A Q ++ ++ LL
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQH-QADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
+N A N+V++ G TPL +A +LG + VL
Sbjct: 755 KNG-ASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 110 bits (275), Expect = 5e-24
Identities = 85/279 (30%), Positives = 132/279 (47%), Gaps = 9/279 (3%)
Query: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
S+ HLAVE G EC + + N G TPLH+A + + VEL+ ++
Sbjct: 440 SLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGV-VELLLARKISVN 498
Query: 181 VTDYKGETVFHYAVQ-GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
D T H+A Q GD S LL +NA +N+V+ +G TP+H+ACQ G++ +VR+L
Sbjct: 499 AKDEDQWTALHFAAQNGDESSTRLLLEKNA--SVNEVDFEGRTPMHVACQHGQENIVRIL 556
Query: 240 LLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNA- 297
L ++ G + + P+H A +++ ++++ G +PLH A
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD-GRTPLHLAAQRG 615
Query: 298 --EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
+AR+L+ +VN S T LHVA A +LL GA +A G T LH
Sbjct: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALH 675
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
LA ++ +K L+ A+V +T LA+ G
Sbjct: 676 LAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714
Score = 82.0 bits (201), Expect = 2e-15
Identities = 61/223 (27%), Positives = 112/223 (50%), Gaps = 10/223 (4%)
Query: 177 TQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMV 236
+ + TD + + + V GD S+++++L V + + G + LHLA + G++E
Sbjct: 398 SDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDV---DLALDSGASLLHLAVEAGQEECA 454
Query: 237 RVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK 295
+ LLL NA N+ G P+H A++ +G E++++ S +++KD + LH+A
Sbjct: 455 KWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS-VNAKDEDQWTA-LHFAA 512
Query: 296 ---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
+ R+LL++ +VN G T +HVA + + +LL G + +G+
Sbjct: 513 QNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWL 572
Query: 353 PLHLAMSKDNVEMIKALIVF-GAEVDTPNDFGETPTFLASKIG 394
PLH A + ++ ++K L G V+ G TP LA++ G
Sbjct: 573 PLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/113 (31%), Positives = 54/113 (47%), Gaps = 3/113 (2%)
Query: 287 GASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANA 343
GAS LH A A E A+ LL N N ++ G+T LH+AV R +LL +
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQ 396
+A+ E T LH A + + L+ A V+ + G TP +A + G++
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/123 (23%), Positives = 58/123 (47%), Gaps = 4/123 (3%)
Query: 309 NVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKA 368
+V+ +G + LH+AV + +CA LL + AN + G+TPLH+A+ + +++
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
Query: 369 LIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLC 428
L+ V+ ++ T A++ G + + + + + + E RT H+ C
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNAS----VNEVDFEGRTPMHVAC 545
Query: 429 LDG 431
G
Sbjct: 546 QHG 548
Score = 36.2 bits (82), Expect = 0.11
Identities = 32/102 (31%), Positives = 45/102 (44%), Gaps = 3/102 (2%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A +G T LHLA R G + LV+ + +T H A +S+V++ L
Sbjct: 665 AMTSDGYTALHLAARNGHLATVKLLVEE-KADVLARGPLNQTALHLAAAHGHSEVVEELV 723
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNI 248
V L + QGL+ LHLA Q + V LL A N+
Sbjct: 724 SADVIDL--FDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 102 bits (255), Expect = 1e-21
Identities = 71/221 (32%), Positives = 110/221 (49%), Gaps = 7/221 (3%)
Query: 179 MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV 238
++ D + T H A ++++++LL + A +N +N LTPLH A +E V+V
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSG-ARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 239 LLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK-- 295
L+ +A N N P+H A CAE+II + SS ++ D R G + LH A
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSS-VNVSD-RGGRTALHHAALN 125
Query: 296 -NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
+ EM +LL +G N+N+ ALH A D +L+ HGA + + G TPL
Sbjct: 126 GHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPL 185
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
H A S + ++K L+ G E+D N +G T +A G+
Sbjct: 186 HAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226
Score = 87.4 bits (215), Expect = 4e-17
Identities = 67/250 (26%), Positives = 116/250 (46%), Gaps = 13/250 (5%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQV-LQLLGR 207
N G T LH+AC G ++ EL+ Y ++ + G T H+A + + L+LL
Sbjct: 211 NVYGNTALHIACYNGQDAVVNELIDY-GANVNQPNNNGFTPLHFAAASTHGALCLELLVN 269
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
N A +N + G +PLH+ G+ + L+ + + +G P+H A ++
Sbjct: 270 NG-ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH-- 326
Query: 267 CAEMIISM--DSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTAL 321
E++I+ S +K + PLH A +++ R LL G +++ G T L
Sbjct: 327 --ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCL 384
Query: 322 HVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
H A +C +L + GA+ + + G TPLH A + + I+ L+ GA V+ +D
Sbjct: 385 HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
Query: 382 FGETPTFLAS 391
+G T A+
Sbjct: 445 WGRTALHYAA 454
Score = 87.4 bits (215), Expect = 4e-17
Identities = 69/217 (31%), Positives = 109/217 (50%), Gaps = 11/217 (5%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
GCT LH G E + L++ + D +G T HYA ++ L L + A++
Sbjct: 678 GCTALHRGIMTGHEECVQMLLEQ-EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALS 736
Query: 212 GLNQV--NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAE 269
+ +NQG TPLH AC G + + VLL +G P+H A+ CA
Sbjct: 737 EEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCAS 796
Query: 270 MII-SMDSSQIHSKDPRYGASPLH---WAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
+++ ++DSS + +D + G +PL +A + E ++LL+ VN+ ++G TAL +A
Sbjct: 797 LLLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAA 855
Query: 326 MRNRFDCAIVLLTHGANAD--ARGEHGNTPLHLAMSK 360
N A+ +L + A AD + + NTPLHLA SK
Sbjct: 856 -ENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSK 891
Score = 82.0 bits (201), Expect = 2e-15
Identities = 60/219 (27%), Positives = 96/219 (43%), Gaps = 11/219 (5%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N G TPLH A G + +EL+ +++ G++ H Q L +N
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNA---RCNIMGPNGYPIHSAMKFSQK 265
++ V+ G TPLH+A + G + ++ L A +C I +P+H A +
Sbjct: 304 G-GEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM--FPLHLAALNAHS 360
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
C ++S +I + D ++G + LH A N E ++L G + + G T LH
Sbjct: 361 DCCRKLLS-SGFEIDTPD-KFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLH 418
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
A F C L+T GAN + + G T LH A + D
Sbjct: 419 YAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
Score = 81.3 bits (199), Expect = 3e-15
Identities = 66/261 (25%), Positives = 121/261 (46%), Gaps = 19/261 (7%)
Query: 147 AENEEGCTPLHLACRKGD---GEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQ 203
A ++ TPLH+A E+++ L+ + ++V+D G T H+A + +++
Sbjct: 77 ARDKNWQTPLHVAAANKAVKCAEVIIPLL----SSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 204 LLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKF 262
LL A +N + + LH A +G ++V +L+ A GY P+H+A
Sbjct: 133 LLLAKG-ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
Query: 263 SQKGCAEMIISM--DSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAG 317
Q + ++++ + +I+ YG + LH A + L+ G NVN ++ G
Sbjct: 192 GQINVVKHLLNLGVEIDEINV----YGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247
Query: 318 NTALHVAVMRNRFD-CAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEV 376
T LH A C +L+ +GA+ + + + G +PLH+ + LI G E+
Sbjct: 248 FTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEI 307
Query: 377 DTPNDFGETPTFLASKIGRQL 397
D + G TP +A++ G +L
Sbjct: 308 DCVDKDGNTPLHVAARYGHEL 328
Score = 75.9 bits (185), Expect = 1e-13
Identities = 71/284 (25%), Positives = 124/284 (43%), Gaps = 40/284 (14%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
+ E TPLH+A GD EI +EL+ +++ D T H AV + + +Q+L ++
Sbjct: 13 DSEKRTPLHVAAFLGDAEI-IELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKH 71
Query: 209 A--------------------------------VAGLNQVNNQGLTPLHLACQLGKQEMV 236
+ ++ +N + G T LH A G EMV
Sbjct: 72 SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMV 131
Query: 237 RVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK 295
+LL A N +H A ++I+ +++ KD + G +PLH A
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN-HGAEVTCKDKK-GYTPLHAAA 189
Query: 296 N---AEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
+ + + LL G ++ + GNTALH+A + L+ +GAN + +G T
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249
Query: 353 PLHLAMSKDNVEM-IKALIVFGAEVDTPNDFGETPTFLASKIGR 395
PLH A + + + ++ L+ GA+V+ + G++P + + GR
Sbjct: 250 PLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGR 293
Score = 75.1 bits (183), Expect = 2e-13
Identities = 90/321 (28%), Positives = 139/321 (43%), Gaps = 26/321 (8%)
Query: 92 LPFYESSPQVLHTEVLQHLTDL-IRNHPSWSVAHLAVELGIRECFHHSRIISCANC--AE 148
L Y Q L +LQ L DL IR+ + LA G EC + I A+ +
Sbjct: 548 LAAYNGHHQALEV-LLQSLVDLDIRDEKGRTALDLAAFKGHTECVE-ALINPGASIFVKD 605
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQ--MDVTDYKGETVFHYAVQGDNSQVLQLLG 206
N TPLH + G L L++ +DV D KG+T AV + + LL
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
A ++ V+ G T LH G +E V++LL G P+H A + +
Sbjct: 666 EKE-ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA---AAR 721
Query: 266 GCAEMIISMDSSQIHSKD----PRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGN 318
G A + + + +D G +PLHWA N +LL++ C GN
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC---FRKFIGN 778
Query: 319 --TALHVAVMRNRFDCAIVLL--THGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
T LH A++ + +CA +LL + R + G TPL A D+VE ++ L+ A
Sbjct: 779 PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838
Query: 375 EVDTPNDFGETPTFLASKIGR 395
V+ ++ G+T +A++ G+
Sbjct: 839 PVNAVDNSGKTALMMAAENGQ 859
Score = 63.9 bits (154), Expect = 5e-10
Identities = 62/262 (23%), Positives = 106/262 (40%), Gaps = 37/262 (14%)
Query: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCT--PLHLACRKGDGEILVEL 171
IR+ ++ H A G R+C + + E++ G T PLHLA G + L L
Sbjct: 502 IRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVL 561
Query: 172 VQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLG 231
+Q +D+ D KG T A +++ ++ L + + N TPLH + G
Sbjct: 562 LQSL-VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVING 620
Query: 232 KQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPL 291
+R+LL I+ + + KD + G +PL
Sbjct: 621 HTLCLRLLLE------------------------------IADNPEAVDVKDAK-GQTPL 649
Query: 292 HWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGE 348
A + + +LL++ NV++ G TALH +M +C +LL + +
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709
Query: 349 HGNTPLHLAMSKDNVEMIKALI 370
G TPLH A ++ + + L+
Sbjct: 710 RGRTPLHYAAARGHATWLSELL 731
Score = 62.4 bits (150), Expect = 1e-09
Identities = 86/352 (24%), Positives = 143/352 (40%), Gaps = 51/352 (14%)
Query: 155 PLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLN 214
PLHLA + +L+ ++D D G T H A G N + ++LL +++ A +
Sbjct: 350 PLHLAALNAHSDCCRKLLS-SGFEIDTPDKFGRTCLHAAAAGGNVECIKLL-QSSGADFH 407
Query: 215 QVNNQGLTPLHLACQLGKQEMVRVLLLCNARCN-----------------------IMG- 250
+ + G TPLH A + L+ A N I+G
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
Query: 251 --PNGYPIHSAMKFSQKG---CAEMIISMDSS-QIHSKDPRYGASPLHWAK---NAEMAR 301
N + A + +K C E ++ D++ I K+ G + +H+A + +
Sbjct: 468 AHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKE---GYNSIHYAAAYGHRQCLE 524
Query: 302 MLLKRGCN--VNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMS 359
+LL+R + S S A + LH+A VLL + D R E G T L LA
Sbjct: 525 LLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAF 584
Query: 360 KDNVEMIKALIVFGAEVDTPNDFGETPTFLASKI-GRQLQDLMHISRARKPAFILGSMRD 418
K + E ++ALI GA + ++ + AS I G L + + A P + ++D
Sbjct: 585 KGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAV--DVKD 642
Query: 419 EKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVA---GTSTG 467
K +L + G + + ++ +EK + V T D+ A G TG
Sbjct: 643 AKGQTPLMLAVAYGHIDAVSLL-----LEKEANVDTVDILGCTALHRGIMTG 689
Score = 45.8 bits (107), Expect = 1e-04
Identities = 27/90 (30%), Positives = 47/90 (52%)
Query: 302 MLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
ML+ + +VN+ S T LHVA + +L+ GA +A+ TPLH A++
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 362 NVEMIKALIVFGAEVDTPNDFGETPTFLAS 391
+ E ++ LI A+V+ + +TP +A+
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAA 90
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 138 SRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGD 197
S I+SC +++G TPL A E L L+++ ++ D G+T A +
Sbjct: 804 SSIVSC----RDDKGRTPLRAAAFADHVECLQLLLRHS-APVNAVDNSGKTALMMAAENG 858
Query: 198 NSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
+ + +L +A A L + TPLHLAC G ++ ++L
Sbjct: 859 QAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 100 bits (248), Expect = 6e-21
Identities = 95/302 (31%), Positives = 144/302 (47%), Gaps = 24/302 (7%)
Query: 120 WSVAHLAVELGIRECFHHSRIISCANCAEN---EEGCTPLHLACRKGDGEILVELVQYCH 176
W+ HLA + +R++ N EG TPLH+A G LV+L+
Sbjct: 462 WTPLHLAAQNNFENV---ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVS-LVKLLTSQG 517
Query: 177 TQMDVTDYKGETVFHYAVQGDNSQVLQ-LLGRNAVAGLNQVNNQGLTPLHLACQLGKQEM 235
++D T H AV+ + +Q LL AV + ++ G PLH A GK +
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP--DALDQSGYGPLHTAAARGKYLI 575
Query: 236 VRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGA---SPL 291
++LL A + G+ P+H A + KG E+I + S H+ GA +PL
Sbjct: 576 CKMLLRYGASLELPTHQGWTPLHLA---AYKGHLEIIHLLAES--HANMGALGAVNWTPL 630
Query: 292 HWA-KNAEMARM--LLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGE 348
H A ++ E A + LL+ G + N+ +G T LH+AV R+ F I LL H AN AR +
Sbjct: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
Query: 349 HGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARK 408
G TP HLA K N ++K L+ GA++D + TP LA + + Q +M ++
Sbjct: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA--LRSRKQGIMSFLEGKE 748
Query: 409 PA 410
P+
Sbjct: 749 PS 750
Score = 86.7 bits (213), Expect = 7e-17
Identities = 72/250 (28%), Positives = 112/250 (44%), Gaps = 10/250 (4%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
E TPLH +G E V L+ +D G T A Q + LL +
Sbjct: 360 ENKVTPLHFLVAQGSVE-QVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHG 418
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
A N+V+ G PLH A Q G R+LL A + G+ P+H A + + + A
Sbjct: 419 -ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 269 EMIISMDSS-QIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+++S + +H + G +PLH A + + ++L +G +++ T LH+A
Sbjct: 478 RLLVSRQADPNLHEAE---GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
V R + LL GA DA + G PLH A ++ + K L+ +GA ++ P G
Sbjct: 535 VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594
Query: 385 TPTFLASKIG 394
TP LA+ G
Sbjct: 595 TPLHLAAYKG 604
Score = 71.2 bits (173), Expect = 3e-12
Identities = 58/189 (30%), Positives = 94/189 (49%), Gaps = 12/189 (6%)
Query: 221 LTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIIS--MDSS 277
+TPLH G E VR+LL + +GY P+ A + Q ++++ D++
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 278 QIHSKDPRYGASPLHWA-KNAE--MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAI 334
++ G +PLH+A +N + AR+LL G V++ G T LH+A N + A
Sbjct: 423 RVDED----GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVAR 478
Query: 335 VLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
+L++ A+ + G TPLH+A +V ++K L GAE+D TP LA + G
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538
Query: 395 --RQLQDLM 401
R +Q L+
Sbjct: 539 KVRAIQHLL 547
Score = 55.5 bits (132), Expect = 2e-07
Identities = 39/137 (28%), Positives = 63/137 (45%), Gaps = 13/137 (9%)
Query: 289 SPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
+PLH+ + E R+LL +V+ +++G T L +A + D +LL HGA+A+
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 346 RGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK----------IGR 395
E G PLH A + + L+ GA VD G TP LA++ + R
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 396 QLQDLMHISRARKPAFI 412
Q +H + + P +
Sbjct: 484 QADPNLHEAEGKTPLHV 500
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 99.8 bits (247), Expect = 8e-21
Identities = 79/299 (26%), Positives = 137/299 (45%), Gaps = 14/299 (4%)
Query: 103 HTEVLQHLTD-----LIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLH 157
H EV++ L ++ S++ H A G+ + + N G TPLH
Sbjct: 185 HIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
Query: 158 LACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQV-LQLLGRNAVAGLNQV 216
+AC G ++ EL+ C ++ + KG T H+A + + L+LL N A +N
Sbjct: 245 VACYNGQDVVVNELID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNG-ADVNMK 302
Query: 217 NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMD 275
+ G TPLH+ G+ + ++ A + NG P+H A ++ + +I+
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
Query: 276 SSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
+ +K +G PLH A + + R LL G ++++ G T LH A +C
Sbjct: 363 ADT--AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 420
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLAS 391
+LL GA+ + + + G +PLH A + N + + AL+ GA V+ ++ G TP A+
Sbjct: 421 LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Score = 99.0 bits (245), Expect = 1e-20
Identities = 66/219 (30%), Positives = 111/219 (50%), Gaps = 7/219 (3%)
Query: 183 DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLC 242
D + T H A ++++++LL + A +N +++ LTPLH A +E V+VLL
Sbjct: 38 DNEKRTPLHAAAYLGDAEIIELLILSG-ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96
Query: 243 NARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAE 298
+A N N P+H A CAE ++ + S ++ D R G + LH A + E
Sbjct: 97 SADVNARDKNWQTPLHIAAANKAVKCAEALVPL-LSNVNVSD-RAGRTALHHAAFSGHGE 154
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
M ++LL RG N+N+ A+H A + +L++HGA + + TPLH A
Sbjct: 155 MVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAA 214
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQL 397
S + ++K L+ G +++ PN +G TP +A G+ +
Sbjct: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV 253
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/236 (30%), Positives = 110/236 (46%), Gaps = 11/236 (4%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
+H A G E++ LV + ++ D K T H A V++ L V +N+
Sbjct: 177 IHWAAYMGHIEVVKLLVSH-GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGV-DMNE 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG-CAEMIIS 273
N G TPLH+AC G+ +V L+ C A N G+ P+H A + C E+++
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294
Query: 274 MDSS-QIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
+ + SKD G +PLH ++ +++ G ++ GNT LH+A
Sbjct: 295 NGADVNMKSKD---GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
L+T GA+ RG HG PLHLA + + L+ G ++DTP+DFG T
Sbjct: 352 ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRT 407
Score = 92.4 bits (228), Expect = 1e-18
Identities = 88/308 (28%), Positives = 135/308 (43%), Gaps = 20/308 (6%)
Query: 96 ESSPQVLHTEVLQHLTDLIRNHPSWSVA-HLAVELGIRECFHHS-RIISCANCAENEEGC 153
E + QVL L+H D+ +W H+A +C ++S N ++ G
Sbjct: 87 EEAVQVL----LKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRA-GR 141
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
T LH A G GE +V+L+ ++ D K H+A + +V++LL + A +
Sbjct: 142 TALHHAAFSGHGE-MVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG-AEV 199
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY---PIHSAMKFSQKGCAEM 270
+ + TPLH A G +V+ LL N PN Y P+H A Q
Sbjct: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN--EPNAYGNTPLHVACYNGQDVVVNE 257
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK----NAEMARMLLKRGCNVNSTSSAGNTALHVAVM 326
+I D I ++ G +PLH+A A +L+ G +VN S G T LH+ +
Sbjct: 258 LI--DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTAL 315
Query: 327 RNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETP 386
RF + ++ GA D ++GNTPLH+A + +I LI GA+ G P
Sbjct: 316 HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFP 375
Query: 387 TFLASKIG 394
LA+ G
Sbjct: 376 LHLAALSG 383
Score = 87.4 bits (215), Expect = 4e-17
Identities = 86/300 (28%), Positives = 133/300 (44%), Gaps = 19/300 (6%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQ--MDVTDYKGETVFHYAV-QGDNSQVLQLLGRNAV 210
TP+H A G E L L+ Q +D+ D G+T +V G V LL + A
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA- 677
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAE 269
++ + G T LH G +E V LL A+C + G PIH + G
Sbjct: 678 -NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736
Query: 270 MII----SMDSSQIHSKDPRYGASPLHWA--KNAEMARMLLKRGCNVNSTSSAGNTALHV 323
++ SMD++ + + +G + LHWA E LL T + LH
Sbjct: 737 ALLQSAASMDANPATADN--HGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHC 794
Query: 324 AVMRNRFDCAIVLL-THGAN-ADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
AV+ + A +L+ T GA+ +A G TPLH A D+VE ++ L+ A+V++ +
Sbjct: 795 AVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDS 854
Query: 382 FGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQ 441
G+TP +A++ G+ M +S A L + K T HL C G L+I++
Sbjct: 855 TGKTPLMMAAENGQTNTVEMLVSSASAE---LTLQDNSKNTALHLACSKGHETSALLILE 911
Score = 86.7 bits (213), Expect = 7e-17
Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 9/219 (4%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHY-AVQGDNSQVLQLLG 206
+NE+G TPLH A G + +EL+ +++ G+T H A+ G S+ ++
Sbjct: 268 KNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQK 265
AV N G TPLH+A + G + ++ L+ A G +G +P+H A
Sbjct: 328 SGAVIDCEDKN--GNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
C ++S I + D +G + LH A N E +LL G + N G + LH
Sbjct: 386 DCCRKLLS-SGFDIDTPDD-FGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLH 443
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
A + C L+ GA+ + E G TPLH A + D
Sbjct: 444 YAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
Score = 82.0 bits (201), Expect = 2e-15
Identities = 67/260 (25%), Positives = 119/260 (45%), Gaps = 17/260 (6%)
Query: 147 AENEEGCTPLHLACRKGD---GEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQ 203
A ++ TPLH+A E LV L+ + ++V+D G T H+A + ++++
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPLL----SNVNVSDRAGRTALHHAAFSGHGEMVK 157
Query: 204 LLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKF 262
LL A +N + + +H A +G E+V++L+ A Y P+H+A
Sbjct: 158 LLLSRG-ANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASS 216
Query: 263 SQKGCAEMIISMDSSQIHSKDPR-YGASPLHWA-KNAE--MARMLLKRGCNVNSTSSAGN 318
+ ++ + + +P YG +PLH A N + + L+ G VN + G
Sbjct: 217 GMISVVKYLLDLG---VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGF 273
Query: 319 TALHVAVMRNRFD-CAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
T LH A C +L+ +GA+ + + + G TPLH+ + +I GA +D
Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID 333
Query: 378 TPNDFGETPTFLASKIGRQL 397
+ G TP +A++ G +L
Sbjct: 334 CEDKNGNTPLHIAARYGHEL 353
Score = 82.0 bits (201), Expect = 2e-15
Identities = 72/265 (27%), Positives = 117/265 (44%), Gaps = 21/265 (7%)
Query: 149 NEEGCTPLHLACRKG-DGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+E GCTPLH A DG+ L L++ + D +G HY+ + LQL+
Sbjct: 468 DERGCTPLHYAATSDTDGKCLEYLLRN-DANPGIRDKQGYNAVHYSAAYGHRLCLQLIAS 526
Query: 208 NA-------VAGLNQV----NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-P 255
+G + + N ++PLHLA G + + VL+ ++ +G P
Sbjct: 527 ETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTP 586
Query: 256 IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNS 312
+ A C +++I+ +S I KD +P+H A ++E R+L+ N+
Sbjct: 587 LDLAAFKGHVECVDVLINQGAS-ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
Query: 313 TS---SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKAL 369
G T L ++V+ DC LL GAN DA+ + G T LH + E + AL
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 370 IVFGAEVDTPNDFGETPTFLASKIG 394
+ GA+ + G TP L++ G
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACG 730
Score = 72.0 bits (175), Expect = 2e-12
Identities = 72/270 (26%), Positives = 114/270 (42%), Gaps = 18/270 (6%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHY-AVQGDNSQVLQLLG 206
++ G TPL L+ G + + L+ +D D G T H AV G V LL
Sbjct: 649 QDGNGQTPLMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQ 707
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNI----MGPNGYP-IHSAMK 261
A L +++G TP+HL+ G ++ LL A + +GY +H A
Sbjct: 708 HGAKCLLR--DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACY 765
Query: 262 FSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKR--GCNVNSTSSA 316
+ C E+++ + + K SPLH A N A ML+ VN+T S
Sbjct: 766 NGHETCVELLLEQE---VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK 822
Query: 317 GNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALI-VFGAE 375
G T LH A + +C +LL+H A ++ G TPL +A ++ L+ AE
Sbjct: 823 GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
Query: 376 VDTPNDFGETPTFLASKIGRQLQDLMHISR 405
+ ++ T LA G + L+ + +
Sbjct: 883 LTLQDNSKNTALHLACSKGHETSALLILEK 912
Score = 68.9 bits (167), Expect = 2e-11
Identities = 74/283 (26%), Positives = 113/283 (39%), Gaps = 44/283 (15%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+++ G T LH G E + L+Q+ + + D +G T H + + VL L
Sbjct: 681 AKDKWGRTALHRGAVTGHEECVDALLQH-GAKCLLRDSRGRTPIHLSAACGHIGVLGALL 739
Query: 207 RNAV---AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFS 263
++A A +N G T LH AC G + V +LL G P+H A+
Sbjct: 740 QSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVIND 799
Query: 264 QKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAG--- 317
+G AEM+I + I + G +PLH A + E ++LL VNS S G
Sbjct: 800 NEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTP 859
Query: 318 -------------------------------NTALHVAVMRNRFDCAIVLL---THGANA 343
NTALH+A + A+++L T
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
Query: 344 DARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETP 386
+A TPLH+A +++ L+ GA V ++ G TP
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 67.8 bits (164), Expect = 4e-11
Identities = 79/278 (28%), Positives = 125/278 (44%), Gaps = 15/278 (5%)
Query: 106 VLQHLTD-LIRNHPSWSVAHLAV---ELGIRECFHHSRIISCANCAE-NEEGCTPLHLAC 160
+LQH L+R+ + HL+ +G+ S AN A + G T LH AC
Sbjct: 705 LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764
Query: 161 RKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL-NQVNNQ 219
G E VEL+ T+ + H AV DN ++L A + N +++
Sbjct: 765 YNGH-ETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK 822
Query: 220 GLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQ 278
G TPLH A E +++LL NA+ N + G P+ A + Q EM++S S++
Sbjct: 823 GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
Query: 279 IHSKD-PRYGASPLHWAKNAEMARMLLKRGCN----VNSTSSAGNTALHVAVMRNRFDCA 333
+ +D + A L +K E + +L+ +N+T++A T LHVA
Sbjct: 883 LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVV 942
Query: 334 IVLLTHGANADARGEHGNTP-LHLAMSKDNVEMIKALI 370
LL GA+ A E+G TP L A +KD + + ++
Sbjct: 943 QELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
Score = 40.0 bits (92), Expect = 0.008
Identities = 24/91 (26%), Positives = 45/91 (49%)
Query: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
R L+ + +VN + T LH A + +L+ GA +A+ TPLH A++
Sbjct: 25 RALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVAS 84
Query: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLAS 391
+ E ++ L+ A+V+ + +TP +A+
Sbjct: 85 CSEEAVQVLLKHSADVNARDKNWQTPLHIAA 115
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 93.6 bits (231), Expect = 6e-19
Identities = 71/213 (33%), Positives = 105/213 (49%), Gaps = 11/213 (5%)
Query: 180 DVTDYKGETVFHYAVQ-GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV 238
DV + T H A Q G++ Q+ QL+ A +NQV +TPLH A G+ V++
Sbjct: 13 DVGFWVERTPVHEAAQRGESLQLQQLIESGAC--VNQVTVDSITPLHAASLQGQARCVQL 70
Query: 239 LLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA--- 294
LL A+ + +G P+ A C ++++S + P Y ASPLH A
Sbjct: 71 LLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKV---NPPLYTASPLHEACMS 127
Query: 295 KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
++E R+L+ G N+ + T LHVA R DC VLL GAN +A H T L
Sbjct: 128 GSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETAL 186
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
H A NV++I+ LI FG + ++ G+ P+
Sbjct: 187 HHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPS 219
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 15/181 (8%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A N +G TPL AC G E + L+ Y +++ Y + H A +S+ ++LL
Sbjct: 80 ARNIDGSTPLCDACASGSIECVKLLLSY-GAKVNPPLYTASPL-HEACMSGSSECVRLL- 136
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKG 266
+ A L + TPLH+AC + V+VLL A N + +H A K
Sbjct: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVD 196
Query: 267 CAEMIISMDSSQIHSKDPRYGASP--LHWAKNA--------EMARMLLKRGCNVNSTSSA 316
EM+I I+++D R G P W+ +A E + L + C VN +
Sbjct: 197 LIEMLIEF-GGNIYARDNR-GKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKAT 254
Query: 317 G 317
G
Sbjct: 255 G 255
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 93.6 bits (231), Expect = 6e-19
Identities = 83/298 (27%), Positives = 145/298 (48%), Gaps = 25/298 (8%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G T + A + G +IL L++ + ++ D G+ H+A GD V+++L R + A
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQ-NVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS-A 521
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEM 270
LN N + TPLH+A G ++V+ LL ++ G P+H A+ S+K +
Sbjct: 522 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAI--SKKRDDIL 579
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLK---RGCNVNSTSSAGNTALHVA 324
+ +++ + G + LH A N R+LL R V+ G TALH+A
Sbjct: 580 AVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 639
Query: 325 VMRNRFDCAIVLLTHG-ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
+ N + A +L+ G AN D + + T LHLA+ + + ++++ L+ GA++D + G
Sbjct: 640 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDG 699
Query: 384 ETPTFLASKIG-----RQLQDLMHISR---ARKPA-----FILGSMRDEKRTHDHLLC 428
+TP A + RQLQD+ + + A +P+ LG+ EK++ + C
Sbjct: 700 DTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIAC 757
Score = 56.2 bits (134), Expect = 1e-07
Identities = 64/274 (23%), Positives = 108/274 (39%), Gaps = 39/274 (14%)
Query: 159 ACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNN 218
A GE L +L++ + D E V A GD ++V LL R V VN
Sbjct: 406 AISNASGERLSQLLKKLFETQESGDLNEELV-KAAANGDVAKVEDLLKRPDV----DVNG 460
Query: 219 Q--GLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDS 276
Q G T + A Q G +++++LL N +G F +G ++ S
Sbjct: 461 QCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS 520
Query: 277 SQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVL 336
+ +++++ R T LH+AV + L
Sbjct: 521 ADLNARNKRR-------------------------------QTPLHIAVNKGHLQVVKTL 549
Query: 337 LTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQ 396
L G + + G+TPLH A+SK +++ L+ GA+V N+ G A+ G
Sbjct: 550 LDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNP 609
Query: 397 LQDLMHISRARKPAFILGSMRDEKRTHDHLLCLD 430
+ +S+ +P +I+ +D+ T HL L+
Sbjct: 610 SAMRVLLSKLPRP-WIVDEKKDDGYTALHLAALN 642
Score = 49.7 bits (117), Expect = 1e-05
Identities = 60/258 (23%), Positives = 103/258 (39%), Gaps = 20/258 (7%)
Query: 115 RNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQY 174
RN + H+AV G + C ++ EG TPLH A K +IL L++
Sbjct: 526 RNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLE- 584
Query: 175 CHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAG--LNQVNNQGLTPLHLACQLGK 232
+ +T+ G H+A N +++L +++ + G T LHLA
Sbjct: 585 AGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNH 644
Query: 233 QEMVRVLL-LCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSS-QIHSKDPRYGAS 289
E+ +L+ NA +I N +H A++ +++ + I KD G +
Sbjct: 645 VEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD---GDT 701
Query: 290 PLHWAKNAEMARML--LKRGCNVNSTSSAGNTALHVAVM---------RNRFDCAIVLLT 338
PLH A L L+ +V +A + + +M ++ A L
Sbjct: 702 PLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAA 761
Query: 339 HGANADARGEHGNTPLHL 356
+GA+ R + G +PL L
Sbjct: 762 NGADLSIRNKKGQSPLDL 779
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 92.8 bits (229), Expect = 1e-18
Identities = 72/249 (28%), Positives = 118/249 (47%), Gaps = 9/249 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A + L + ++V D G + H+AV + + + LL N A L
Sbjct: 109 TPLHVAAANRATKCAEALAPLL-SSLNVADRSGRSALHHAVHSGHLETVNLL-LNKGASL 166
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPI-HSAMKFSQKGCAEMII 272
N + + PLH A LG E++++L+ A GY + H+A Q + ++
Sbjct: 167 NVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVA-VMRN 328
M + + +G + LH A +A L+ G NVN + G T LHVA V N
Sbjct: 227 RMGAEI--DEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN 284
Query: 329 RFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTF 388
C +L+ +GA+ + + + G +PLH+A + LI G+E+D + FG TP
Sbjct: 285 GALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLH 344
Query: 389 LASKIGRQL 397
+A++ G +L
Sbjct: 345 VAARYGHEL 353
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/244 (25%), Positives = 114/244 (46%), Gaps = 16/244 (6%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N++G TPLH+A +G + +EL+ ++ +G++ H A Q+L +N
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGC 267
+ ++ + G TPLH+A + G + ++ L+ A G + +P+H A+ F C
Sbjct: 329 G-SEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDC 387
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++S S Q++S ++ +L G ++N+ + G T LH A
Sbjct: 388 CRKLLS--SGQLYS------------IVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASG 433
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
+C +LL+ GA+ R + G TPLH A + + + L+ GA V+ + G +P
Sbjct: 434 GNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL 493
Query: 388 FLAS 391
A+
Sbjct: 494 HYAA 497
Score = 83.2 bits (204), Expect = 8e-16
Identities = 65/221 (29%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 179 MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV 238
++V D + T H A + +LQLL + A +N + LTPLH A ++++ +
Sbjct: 34 INVLDQERRTPLHAAAYVGDVPILQLLLMSG-ANVNAKDTLWLTPLHRAAASRNEKVLGL 92
Query: 239 LLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNA 297
LL +A N P+H A CAE + + SS ++ D R G S LH A ++
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS-LNVAD-RSGRSALHHAVHS 150
Query: 298 ---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
E +LL +G ++N LH A + +L+ GA+ + G L
Sbjct: 151 GHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLL 210
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
H A + +E++K L+ GAE+D PN FG T +A +G+
Sbjct: 211 HTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
Score = 82.8 bits (203), Expect = 1e-15
Identities = 84/299 (28%), Positives = 128/299 (42%), Gaps = 18/299 (6%)
Query: 106 VLQHLTDLIRNHPSWSVA-HLAVELGIRECFHH-SRIISCANCAENEEGCTPLHLACRKG 163
+L H D+ W H+A +C + ++S N A+ G + LH A G
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS-GRSALHHAVHSG 151
Query: 164 DGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLL-GRNAVAGLNQVNNQGLT 222
E V L+ ++V D K H+A + +VL+LL R A G GL
Sbjct: 152 HLET-VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGL- 209
Query: 223 PLHLACQLGKQEMVRVLLLCNARCNIMGPNGY---PIHSAMKFSQKGCAEMIISMDSSQI 279
LH A G+ E+V+ LL A I PN + +H A Q A +++ ++
Sbjct: 210 -LHTAAASGQIEVVKYLLRMGAE--IDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
Query: 280 HSKDPRYGASPLHWA----KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIV 335
D G +PLH A A +L+ G +VN S G + LH+A + RF + +
Sbjct: 267 QPNDK--GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQI 324
Query: 336 LLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
L+ +G+ D + GNTPLH+A + +I L+ GA+ P LA G
Sbjct: 325 LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFG 383
Score = 80.5 bits (197), Expect = 5e-15
Identities = 70/248 (28%), Positives = 109/248 (43%), Gaps = 10/248 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
++E TPLH A GD IL +L+ ++ D T H A N +VL LL +
Sbjct: 38 DQERRTPLHAAAYVGDVPIL-QLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAH 96
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGC 267
+ A +N + TPLH+A + L + N+ +G +H A+
Sbjct: 97 S-ADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLET 155
Query: 268 AEMIISMDSS-QIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHV 323
++++ +S + K R PLHWA + E+ ++L+ RG ++ G LH
Sbjct: 156 VNLLLNKGASLNVCDKKER---QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHT 212
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A + + LL GA D GNT LH+A + L+ GA V+ PND G
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
Query: 384 ETPTFLAS 391
TP +A+
Sbjct: 273 FTPLHVAA 280
Score = 79.0 bits (193), Expect = 2e-14
Identities = 70/276 (25%), Positives = 115/276 (41%), Gaps = 40/276 (14%)
Query: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGC---TPLHLACRKGDGEILVE 170
+R+ ++ H A G R+ +S NC E+ E +PLHLA G E L
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSF-NCLEDVESTIPVSPLHLAAYNGHCEALKT 603
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
L + +DV D+KG T A + +++ +++L + + L + + TPLH A
Sbjct: 604 LAETL-VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
Query: 231 GKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASP 290
G + + +L+ R A++ MD+ YG +P
Sbjct: 663 GHTDSLHLLIDSGER----------------------ADITDVMDA---------YGQTP 691
Query: 291 LHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARG 347
L A + + +LL++G ++ G TALH + DC LL H A R
Sbjct: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751
Query: 348 EHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
G TP+HLA + + +++ L+ D P D G
Sbjct: 752 FKGRTPIHLASACGHTAVLRTLLQAALSTD-PLDAG 786
Score = 76.6 bits (187), Expect = 8e-14
Identities = 79/283 (27%), Positives = 124/283 (43%), Gaps = 17/283 (6%)
Query: 125 LAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDY 184
LA+ G +C H A + G T LH G + L L+ + + D+
Sbjct: 694 LAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL-CRDF 752
Query: 185 KGETVFHYAVQGDNSQVLQLLGRNAV------AGLNQVNNQGLTPLHLACQLGKQEMVRV 238
KG T H A ++ VL+ L + A+ AG V+ G +P+H A G ++ + +
Sbjct: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAG---VDYSGYSPMHWASYTGHEDCLEL 809
Query: 239 LLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLH---WAK 295
LL + + G P+H A+ +Q EM++ ++I + G +PLH +A
Sbjct: 810 LLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFAD 869
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHG-ANADARGEHGNTPL 354
N RMLL+ VN+T G TAL A + LL G A+ E+ NT L
Sbjct: 870 NVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTAL 929
Query: 355 HLAMSKDNVE---MIKALIVFGAEVDTPNDFGETPTFLASKIG 394
HLA SK + + MI A ++ N + P +A++ G
Sbjct: 930 HLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972
Score = 76.3 bits (186), Expect = 1e-13
Identities = 79/298 (26%), Positives = 122/298 (40%), Gaps = 64/298 (21%)
Query: 155 PLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLN 214
PLH A G E+L LV + D KG + H A +V++ L R A ++
Sbjct: 176 PLHWAAFLGHLEVLKLLVAR-GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG-AEID 233
Query: 215 QVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPN--GY-PIH-SAMKFSQKGCAEM 270
+ N G T LH+AC LG+ + + L NA N+ PN G+ P+H +A+ + C E+
Sbjct: 234 EPNAFGNTALHIACYLGQDAVA--IELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLEL 291
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
+++ + + + G SPLH A +++L++ G ++ GNT LHVA
Sbjct: 292 LVNNGADVNYQS--KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY 349
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAM----------------------------- 358
L+T+GA+ RG H PLHLA+
Sbjct: 350 GHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHV 409
Query: 359 ----------------------SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
S NVE + L+ GA++ + FG TP A+ G
Sbjct: 410 LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467
Score = 72.0 bits (175), Expect = 2e-12
Identities = 91/356 (25%), Positives = 139/356 (39%), Gaps = 25/356 (7%)
Query: 103 HTEVLQHLTDL-----IRNHPSWSVAHLAVELGIRECFH----HSRIISCANCAENEEGC 153
H E L+ L + +R+H + LA E G EC H + A E +
Sbjct: 597 HCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHG---ASALIKERKRKW 653
Query: 154 TPLHLACRKGDGEILVELVQYCHTQ--MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
TPLH A G + L L+ DV D G+T A+ + + LL
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEM 270
+ + +G T LH G ++ + LL +A G PIH A
Sbjct: 714 A-DAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
Query: 271 II--SMDSSQIHSKDPRYGASPLHWAKNA--EMARMLLKRGCNVNSTSSAGNTALHVAVM 326
++ ++ + + + G SP+HWA E LL + T LH AV+
Sbjct: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVI 832
Query: 327 RNRFDCAIVLL-THGAN-ADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
N+ +LL GA ++R G TPLH A DNV ++ L+ AEV+ + G
Sbjct: 833 NNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892
Query: 385 TPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIII 440
T A++ G+ + R + +L + K T HL C G L+I+
Sbjct: 893 TALMTAAENGQTAAVEFLLYRGKADLTVLD---ENKNTALHLACSKGHEKCALMIL 945
Score = 65.9 bits (159), Expect = 1e-10
Identities = 62/220 (28%), Positives = 96/220 (43%), Gaps = 9/220 (4%)
Query: 183 DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQ-GLTPLHLACQLGKQEMVRVLLL 241
D +G T HYA N Q L+LL + L V + ++PLHLA G E ++ L
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
Query: 242 CNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NA 297
++ G + A + C E++ + +S + K+ + +PLH A +
Sbjct: 607 TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL-IKERKRKWTPLHAAAASGHT 665
Query: 298 EMARMLLKRGCNVNSTS---SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
+ +L+ G + T + G T L +A+M DC +LL G+ ADA G T L
Sbjct: 666 DSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
H + + AL+ A V + G TP LAS G
Sbjct: 726 HRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACG 765
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/99 (28%), Positives = 48/99 (48%)
Query: 293 WAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
++++ E R LL + N+N T LH A +LL GAN +A+ T
Sbjct: 17 FSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLT 76
Query: 353 PLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLAS 391
PLH A + N +++ L+ A+V+ + +TP +A+
Sbjct: 77 PLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAA 115
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 90.9 bits (224), Expect = 4e-18
Identities = 69/250 (27%), Positives = 119/250 (47%), Gaps = 8/250 (3%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G PL +A G+ +IL L++ +++DV D G ++A + + L+ L N
Sbjct: 376 NKHGTPPLLIAAGCGNIQILQLLIKR-GSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
L+ + G LH+A + G ++ ++L + NI P+H A
Sbjct: 435 KCP-LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSV 493
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVA 324
A+ + + ++ K+ R G +PL A ++ L + G ++N+ G+ ALH+A
Sbjct: 494 AKALCEAGCN-VNIKN-REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
V R + + LL+ G D + HGNTPLH+A N+ ++ AL +D N +G
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGR 611
Query: 385 TPTFLASKIG 394
TP LA+ G
Sbjct: 612 TPLHLAANNG 621
Score = 82.0 bits (201), Expect = 2e-15
Identities = 70/251 (27%), Positives = 114/251 (45%), Gaps = 16/251 (6%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLL-- 205
+++ G ++ A R G + L L + +DV D GE H A + ++ V QLL
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSEN-KCPLDVKDKSGEMALHVAARYGHADVAQLLCS 466
Query: 206 -GRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQ 264
G N N + + TPLH A G + + L C A CN+ N + S
Sbjct: 467 FGSNP----NIQDKEEETPLHCAAWHGYYSVAKAL--CEAGCNVNIKNREGETPLLTASA 520
Query: 265 KGCAEMI--ISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNT 319
+G +++ ++ + +++ D + G LH A E+ + LL +GC V+ GNT
Sbjct: 521 RGYHDIVECLAEHGADLNACD-KDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Query: 320 ALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTP 379
LHVA + L N D ++G TPLHLA + +++++ L + GA V+
Sbjct: 580 PLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEAL 639
Query: 380 NDFGETPTFLA 390
G+T LA
Sbjct: 640 TTDGKTAEDLA 650
Score = 79.7 bits (195), Expect = 9e-15
Identities = 66/242 (27%), Positives = 104/242 (42%), Gaps = 42/242 (17%)
Query: 192 YAVQGDNSQVLQ-LLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMG 250
+A+ DN LQ LLG + +NQ N G PL +A G +++++L+ +R ++
Sbjct: 350 HAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQD 409
Query: 251 PNG----------------------------------YPIHSAMKFSQKGCAEMIISMDS 276
G +H A ++ A+++ S S
Sbjct: 410 KGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGS 469
Query: 277 S-QIHSKDPRYGASPLH---WAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
+ I K+ +PLH W +A+ L + GCNVN + G T L A R D
Sbjct: 470 NPNIQDKEEE---TPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDI 526
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
L HGA+ +A + G+ LHLA+ + +E+IK L+ G VD + G TP +A K
Sbjct: 527 VECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACK 586
Query: 393 IG 394
G
Sbjct: 587 DG 588
Score = 61.6 bits (148), Expect = 3e-09
Identities = 61/225 (27%), Positives = 95/225 (42%), Gaps = 10/225 (4%)
Query: 143 CANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVL 202
C +++ G LH+A R G ++ L + + ++ D + ET H A V
Sbjct: 436 CPLDVKDKSGEMALHVAARYGHADVAQLLCSF-GSNPNIQDKEEETPLHCAAWHGYYSVA 494
Query: 203 QLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKF 262
+ L A +N N +G TPL A G ++V L A N +G H A+
Sbjct: 495 KALCE-AGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDG---HIALHL 550
Query: 263 SQKGCAEMIISMDSSQIHSKD--PRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAG 317
+ + C +I SQ D R+G +PLH A N + L + CN++ ++ G
Sbjct: 551 AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYG 610
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDN 362
T LH+A D L GA+ +A G T LA S+ +
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQH 655
>gi|21264330 mindbomb homolog 2 [Homo sapiens]
Length = 1013
Score = 87.4 bits (215), Expect = 4e-17
Identities = 70/250 (28%), Positives = 125/250 (50%), Gaps = 15/250 (6%)
Query: 151 EGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAV 210
+G T L +A G E L+ L+ +D+ D +G T HYA G+ + ++L +A
Sbjct: 522 QGRTALQVAAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVL-LSAG 579
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY---PIHSAMK--FSQK 265
+ +N+ T LH+A Q G E+VR LC C++ P+ + P+HSA+
Sbjct: 580 CRADAINSTQSTALHVAVQRGFLEVVRA--LCERGCDVNLPDAHSDTPLHSAISAGTGAS 637
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCN-VNSTSSAGNTAL 321
G E++ + + + + + + G + LH A +A R +L R V++ G TAL
Sbjct: 638 GIVEVLTEVPNIDVTATNSQ-GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTAL 696
Query: 322 HVAVMRNRFDCAIVLLTHG-ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN 380
H+A + N + A +L+ G + + R +PLHLA+ + +V ++ L+ G V+ +
Sbjct: 697 HLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAED 756
Query: 381 DFGETPTFLA 390
+ G+T +A
Sbjct: 757 EEGDTALHVA 766
Score = 65.9 bits (159), Expect = 1e-10
Identities = 76/286 (26%), Positives = 129/286 (45%), Gaps = 36/286 (12%)
Query: 138 SRIISCANC---AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVT--DYKGETVFHY 192
+R++ A C A N T LH+A ++G E++ L C DV D +T H
Sbjct: 572 TRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL---CERGCDVNLPDAHSDTPLHS 628
Query: 193 AVQGDN--SQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR-VLLLCNARCNIM 249
A+ S ++++L + N+QG T LH A G VR +L +
Sbjct: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAK 688
Query: 250 GPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLK 305
+G+ +H A + + A+++I ++ ++ + SPLH A + + +L+
Sbjct: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD 747
Query: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANAD-----------ARGEHGNTPL 354
GC+VN+ G+TALHVA+ R++ + L+ GA D A G G+ L
Sbjct: 748 AGCSVNAEDEEGDTALHVALQRHQL---LPLVADGAGGDPGPLQLLSRLQASGLPGSAEL 804
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDL 400
+ + + L + GA+V N G +P LA++ GR L+ L
Sbjct: 805 TVGAA-----VACFLALEGADVSYTNHRGRSPLDLAAE-GRVLKAL 844
Score = 64.3 bits (155), Expect = 4e-10
Identities = 70/266 (26%), Positives = 114/266 (42%), Gaps = 48/266 (18%)
Query: 183 DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVN--NQGLTPLHLACQLGKQEMVRVLL 240
++ G V A+ G+ ++ L LL R QV+ NQG T L +A LG+ E++R+LL
Sbjct: 489 EHPGRLVVEVAL-GNAARALDLLRRRP----EQVDTKNQGRTALQVAAYLGQVELIRLLL 543
Query: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
A ++ G ++A+ ++ G E
Sbjct: 544 QARAGVDLPDDEG---NTALHYAALG----------------------------NQPEAT 572
Query: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
R+LL GC ++ +S +TALHVAV R + L G + + H +TPLH A+S
Sbjct: 573 RVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISA 632
Query: 361 DN-----VEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGS 415
VE++ V +V N G T AS G L ++RAR+ ++ +
Sbjct: 633 GTGASGIVEVLTE--VPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQ---LVDA 687
Query: 416 MRDEKRTHDHLLCLDGGGVKGLIIIQ 441
+++ T HL L+ I+I+
Sbjct: 688 KKEDGFTALHLAALNNHREVAQILIR 713
Score = 45.1 bits (105), Expect = 2e-04
Identities = 36/129 (27%), Positives = 55/129 (42%), Gaps = 2/129 (1%)
Query: 268 AEMIISMDSSQIHSKDPRY-GASPLHWAK-NAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
+ + +++D + DP + G + A NA A LL+R T + G TAL VA
Sbjct: 472 SSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAA 531
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
+ + +LL A D + GNT LH A + E + L+ G D N T
Sbjct: 532 YLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQST 591
Query: 386 PTFLASKIG 394
+A + G
Sbjct: 592 ALHVAVQRG 600
>gi|48525351 patatin-like phospholipase domain containing 8 [Homo
sapiens]
Length = 782
Score = 85.5 bits (210), Expect = 2e-16
Identities = 100/379 (26%), Positives = 155/379 (40%), Gaps = 63/379 (16%)
Query: 395 RQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVAT 454
RQ++D + R+ ++G + K +L +DGGG +G++ +Q L + + +
Sbjct: 413 RQIKDETLQAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPV 472
Query: 455 KDLFDWVAGTSTGGILALAI-LHSKSMAYMRGMYFRMKDEVFR------------GSRPY 501
LFD++ G STG ILA + L + +Y ++ +VF Y
Sbjct: 473 HQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFY 532
Query: 502 ESGPLEEFLKREFGEHTKMTDVRK---PKVMLTGTLSDRQ-PAELHLFRNYDAPETVREP 557
+S E LK G + R PKV T+ +R + +FRNY P
Sbjct: 533 DSQTWENILKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYG-----HFP 587
Query: 558 RFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRP----NGRFLDGGLLANNPTLDAMTE 613
N + +W+A R+S AAP YF N DGGLL NNP+ AM E
Sbjct: 588 GINSHY-----LGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALAMHE 642
Query: 614 IHEYNQDLIRKGQANKVKKLSIVVSLGTGR-SPQVPVTCVDVFRPSNPWELAKTVFGAKE 672
D+ L +VSLGTGR V T V S +L+ + A +
Sbjct: 643 CKCLWPDV----------PLECIVSLGTGRYESDVRNT---VTYTSLKTKLSNVINSATD 689
Query: 673 LGK--MVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWE 730
+ +++D PD YFR NP + +I LDE + L E
Sbjct: 690 TEEVHIMLDGLLPPD----------------TYFRFNPVMCENIPLDESRNEKLDQLQLE 733
Query: 731 TEVYIYEHREEFQKLIQLL 749
YI + ++ +K+ ++L
Sbjct: 734 GLKYIERNEQKMKKVAKIL 752
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 85.1 bits (209), Expect = 2e-16
Identities = 64/228 (28%), Positives = 109/228 (47%), Gaps = 17/228 (7%)
Query: 177 TQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMV 236
+Q D E + A +G V+QL+ + A V G TPLHLA G +V
Sbjct: 2 SQQDAVAALSERLLVAAYKGQTENVVQLINKGARVA---VTKHGRTPLHLAANKGHLPVV 58
Query: 237 RVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHS-----KDPRYGASPL 291
++LL A C++ + + + + G E+I ++ IH + + G + L
Sbjct: 59 QILL--KAGCDLDVQDDGDQTALHRATVVGNTEIIAAL----IHEGCALDRQDKDGNTAL 112
Query: 292 H---WAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGE 348
H W ++ A++L+K G NV + + AGNTALH+A + VLL G+ AD +
Sbjct: 113 HEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNN 172
Query: 349 HGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQ 396
G+T LH+A +++ +I+ L+ V N G+T +A+ + +
Sbjct: 173 AGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHK 220
Score = 78.2 bits (191), Expect = 3e-14
Identities = 65/246 (26%), Positives = 108/246 (43%), Gaps = 39/246 (15%)
Query: 144 ANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQ 203
A A + G TPLHLA KG + V+++ +DV D +T H A N++++
Sbjct: 34 ARVAVTKHGRTPLHLAANKGHLPV-VQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIA 92
Query: 204 LLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFS 263
L A L++ + G T LH A G + + LL A N++ N
Sbjct: 93 ALIHEGCA-LDRQDKDGNTALHEASWHGFSQSAK--LLVKAGANVLAKN----------- 138
Query: 264 QKGCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTA 320
+ G + LH A +++ R+LL G + ++AG+T
Sbjct: 139 ---------------------KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTC 177
Query: 321 LHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN 380
LHVA N +LLT + + + G+T LH+A + ++ ++ K L+ GA+ N
Sbjct: 178 LHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVN 237
Query: 381 DFGETP 386
+ G+TP
Sbjct: 238 NAGQTP 243
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 84.0 bits (206), Expect = 5e-16
Identities = 66/246 (26%), Positives = 107/246 (43%), Gaps = 41/246 (16%)
Query: 151 EGCTPLHLACR---KGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
EGC + C G E L E + + TD T H+A ++++++ L +
Sbjct: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGC 267
V +N ++ G +PLH+A G+ E+V+ LL A+ N + N
Sbjct: 62 LGVP-VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN--------------- 105
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVA 324
G +PLH+A + E+A MLL+ G N ++ TA+H A
Sbjct: 106 -------------------GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ +LL + A+ + + GNTPLHLA ++ VE K L+ GA + N +
Sbjct: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEK 206
Query: 385 TPTFLA 390
TP +A
Sbjct: 207 TPLQVA 212
Score = 63.9 bits (154), Expect = 5e-10
Identities = 58/213 (27%), Positives = 94/213 (44%), Gaps = 41/213 (19%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
+++ T LH AC G EI+ L+Q LG
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQ-------------------------------LG-- 63
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGC 267
+N ++ G +PLH+A G+ E+V+ LL A+ N + NG P+H A ++
Sbjct: 64 --VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
A M++ + +KD Y A+ +H A N +M +LL + N + GNT LH+A
Sbjct: 122 AVMLLE-GGANPDAKD-HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
R + A +L++ GA+ + TPL +A
Sbjct: 180 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
Score = 59.3 bits (142), Expect = 1e-08
Identities = 38/107 (35%), Positives = 53/107 (49%), Gaps = 3/107 (2%)
Query: 291 LHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARG 347
LHWA +A E+ LL+ G VN AG + LH+A R + LL GA +A
Sbjct: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
Query: 348 EHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
++G TPLH A SK+ E+ L+ GA D + + T A+ G
Sbjct: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKG 150
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/143 (30%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 103 HTEVLQHLTDL-----IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLH 157
HTE+++ L L ++ WS H+A G E A N+ GCTPLH
Sbjct: 52 HTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLH 111
Query: 158 LACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVN 217
A K EI V L++ D D+ T H A N +++ +L A N +
Sbjct: 112 YAASKNRHEIAVMLLE-GGANPDAKDHYEATAMHRAAAKGNLKMIHIL-LYYKASTNIQD 169
Query: 218 NQGLTPLHLACQLGKQEMVRVLL 240
+G TPLHLAC + E ++L+
Sbjct: 170 TEGNTPLHLACDEERVEEAKLLV 192
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/115 (28%), Positives = 49/115 (42%)
Query: 295 KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
K E+ +L T TALH A + LL G + + + G +PL
Sbjct: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKP 409
H+A S E++KAL+ GA+V+ N G TP A+ R +M + P
Sbjct: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
>gi|134133226 protein expressed in prostate, ovary, testis, and
placenta 2 [Homo sapiens]
Length = 1075
Score = 81.6 bits (200), Expect = 2e-15
Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 4/148 (2%)
Query: 245 RCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMAR 301
R ++ G + +H A + + ++I+ + + ++ KD + + LH A N+E+ +
Sbjct: 132 RYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKD-KQKRTALHLASANGNSEVVK 190
Query: 302 MLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
+LL R C +N + TAL AV +CA++LL HG + + E+GNT LH A+ +
Sbjct: 191 LLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNE 250
Query: 362 NVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ M KAL+++GA++++ N G TP L
Sbjct: 251 DKLMAKALLLYGADIESKNKHGLTPLLL 278
Score = 59.7 bits (143), Expect = 1e-08
Identities = 50/178 (28%), Positives = 79/178 (44%), Gaps = 31/178 (17%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N+ + Q T LHLA G E+V++LL + RC + + + +K Q C E
Sbjct: 166 VNKKDKQKRTALHLASANGNSEVVKLLL--DRRCQLNVLDNKKRTALIKAVQ--CQE--- 218
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
E A MLL+ G + N GNT LH A+
Sbjct: 219 ------------------------DECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLM 254
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 255 AKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILA 312
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T ++ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 158 IVMLRDTDVNKKDKQKRTALHLASANGNSEVVKLL-LDRRCQLNVLDNKKRTALIKAVQC 216
Query: 231 GKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 217 QEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 274
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G TAL +AV +LL + +
Sbjct: 275 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSS 333
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 334 QDLSGQTAREYAVS 347
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 81.3 bits (199), Expect = 3e-15
Identities = 75/279 (26%), Positives = 125/279 (44%), Gaps = 14/279 (5%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
HLA G+ E A++ EG TP+H+A G I+ LV + ++V D
Sbjct: 776 HLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRD 835
Query: 184 YKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCN 243
+G T F A+ N++ + + + QV+N+G LH+A Q E V L+ +
Sbjct: 836 RQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVH 895
Query: 244 ARCNIMGPNG---YPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEM- 299
A N + P+H A++ + ++ + ++ ++ + LH A ++
Sbjct: 896 ANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKV--NELTKHRQTALHLAAQQDLP 953
Query: 300 --ARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTH-GANADARGEHGNTPLHL 356
+LL+ G + + GN ALH+AVM R + VLLT +A+A G +PLH+
Sbjct: 954 TICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHI 1013
Query: 357 --AMSKDNVEMIKALIVF---GAEVDTPNDFGETPTFLA 390
K+N I L + G +D P+ G T LA
Sbjct: 1014 LGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLA 1052
Score = 75.9 bits (185), Expect = 1e-13
Identities = 78/344 (22%), Positives = 132/344 (38%), Gaps = 93/344 (27%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGET-----VFHYAVQGDNS--- 199
++ +G TPLH++ G+ + +L+Q +++ D++G T V H V D S
Sbjct: 363 QDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNP 422
Query: 200 -------------------QVLQ---------------LLGRNAVAG------------- 212
+++Q LL R A AG
Sbjct: 423 FEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGA 482
Query: 213 -LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPI--------------- 256
+N N G TPLH AC+ G + LL A N+ P+
Sbjct: 483 HVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVH 542
Query: 257 -----HSAMKFSQKGCAEMIISMDSSQIHSKD-----PRYGASPLH---------WAKNA 297
H A+ ++ +I+ ++ +H+ + P + W
Sbjct: 543 LQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMH 602
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANAD-ARGEHGNTPLHL 356
+A LL G +N T S G T LH+A+ R A+ LL H A+ + +R + G T L L
Sbjct: 603 TIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQL 662
Query: 357 AMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDL 400
A+ ++ A+ GA++ P++ G P +LA + L+D+
Sbjct: 663 AIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLA--LANNLEDI 704
Score = 65.5 bits (158), Expect = 2e-10
Identities = 69/253 (27%), Positives = 99/253 (39%), Gaps = 39/253 (15%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
E +G TPLHLA G E + L+++ ++ D +G T H A+ + ++QLL
Sbjct: 767 EARDGQTPLHLAASWGLEETVQCLLEF-GANVNAQDAEGRTPIHVAISSQHGVIIQLLVS 825
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGC 267
+ LN + QGLTP AC AM F
Sbjct: 826 HPDIHLNVRDRQGLTPF--AC------------------------------AMTFKNNKS 853
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGN--TALH 322
AE I+ +S D + G + LH A + E L+ NVNS + T LH
Sbjct: 854 AEAILKRESGAAEQVDNK-GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLH 912
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+AV LL GA + +H T LHLA +D + L+ G + ++
Sbjct: 913 LAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDEN 972
Query: 383 GETPTFLASKIGR 395
G LA GR
Sbjct: 973 GNNALHLAVMHGR 985
Score = 57.8 bits (138), Expect = 4e-08
Identities = 69/283 (24%), Positives = 117/283 (41%), Gaps = 38/283 (13%)
Query: 142 SCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVT------------DYKGETV 189
S + A++ TPLH+A +++ +++ + T D + +TV
Sbjct: 533 SLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTV 592
Query: 190 FHYAV-QGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNI 248
A+ G ++ QLLG A +N + G T LH+A Q +Q+ L L + +I
Sbjct: 593 LGLALWTGMHTIAAQLLGSGAA--INDTMSDGQTLLHMAIQ--RQDSKSALFLLEHQADI 648
Query: 249 MGPNGYPIHSAMKFSQKGCAEMIISMDSSQ-IHSKDPRYGASPLHW---AKNAE-MARML 303
+A++ + + +++ ++ P +P W A N E +A L
Sbjct: 649 NVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTL 708
Query: 304 LKRGCNVN----STSSAGNTALHVAVMRNRFDCAIVLLTHGAN--------ADARGEH-- 349
++ GC+ T LH A+ N A L+ G + A+ GE
Sbjct: 709 VRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEA 768
Query: 350 --GNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
G TPLHLA S E ++ L+ FGA V+ + G TP +A
Sbjct: 769 RDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVA 811
Score = 53.1 bits (126), Expect = 9e-07
Identities = 55/237 (23%), Positives = 97/237 (40%), Gaps = 50/237 (21%)
Query: 151 EGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYK---GETVFHYAVQGDNSQVLQLLGR 207
+G T LH+A ++ D + + L+++ Q D+ + GET A++ V+ +
Sbjct: 621 DGQTLLHMAIQRQDSKSALFLLEH---QADINVSRTQDGETALQLAIRNQLPLVVDAICT 677
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLL--CNARCNIMGPNGYPIHSAMKFSQK 265
A ++ + +G PL LA +++ L+ C+A C GP G
Sbjct: 678 RG-ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGG------------ 724
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAG-------- 317
C + ++ + N A L++ GC+VNS G
Sbjct: 725 -CLQTLLHRAIDE----------------NNEPTACFLIRSGCDVNSPRQPGANGEGEEE 767
Query: 318 ----NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALI 370
T LH+A + LL GAN +A+ G TP+H+A+S + +I+ L+
Sbjct: 768 ARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLV 824
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/211 (23%), Positives = 89/211 (42%), Gaps = 29/211 (13%)
Query: 155 PLHLACRKGDGEI----LVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAV 210
PLH A + ++ L+E+ +++ D+ G+ A+ + L +
Sbjct: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHK- 279
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNI--MGPNGYPIHSAMKFSQKGCA 268
A ++ V+ G + LH Q G L+ A N +G P+H
Sbjct: 280 ADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLH----------- 328
Query: 269 EMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR- 327
++++ SS+ HS D ++ A++A LL+ G N N S G T LHV++M
Sbjct: 329 --LVALYSSKKHSADVM--------SEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
N + + +L + + + G+T L LA+
Sbjct: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAV 409
Score = 34.7 bits (78), Expect = 0.33
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 12/83 (14%)
Query: 300 ARMLLKRGCNVNS-TSSAGNTALHVA-----------VMRNRFDCAIVLLTHGANADARG 347
A L+K G VN+ T A T LH+ VM A LL GAN + +
Sbjct: 305 ATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQD 364
Query: 348 EHGNTPLHLAMSKDNVEMIKALI 370
G TPLH+++ N + L+
Sbjct: 365 SKGRTPLHVSIMAGNEYVFSQLL 387
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 80.5 bits (197), Expect = 5e-15
Identities = 74/287 (25%), Positives = 132/287 (45%), Gaps = 17/287 (5%)
Query: 124 HLAVELGIRECFHHSRIISCA-NCAEN-----EEGCTPLHLACRKGDGEILVELVQYCHT 177
H + L R+ H+++++C C N ++G T L A G E++ L+ Y
Sbjct: 579 HTPLTLAARQ--GHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGV 635
Query: 178 QMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR 237
++D D T A G + ++ L ++ A +N+ +N+G T L A +G +E+V
Sbjct: 636 KVDCADADSRTALRAAAWGGHEDIVLNLLQHG-AEVNKADNEGRTALIAAAYMGHREIVE 694
Query: 238 VLLLCNARCN---IMGPNGYPIHSAMKFSQKGCAEMI-ISMDSSQIHSKDPRYGASPLHW 293
LL A N + G + + + KG A ++ + +D + G +PL
Sbjct: 695 HLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLV 754
Query: 294 AK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHG 350
A + ++ +LL+ G +V+ T + G T L A LL GA D+ G
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Query: 351 NTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQL 397
T L +A ++ NVE+++ L+ G + + +D G TP +A+ G +L
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL 861
Score = 76.6 bits (187), Expect = 8e-14
Identities = 61/236 (25%), Positives = 107/236 (45%), Gaps = 6/236 (2%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYA-VQGDNSQVLQLLGR 207
+ G TPL A G ++ L+ + +D D +G TV A QG+ V LL R
Sbjct: 778 DNNGRTPLLAAASMGHASVVNTLL-FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKG 266
N ++ G TPLH+A G + + L+ AR N + +G P A +
Sbjct: 837 GLDE--NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYD 894
Query: 267 CAEMIISMDSS-QIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
C ++++ S+ D R + ++ +L G +VN + G L++
Sbjct: 895 CVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILA 954
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
+ N+ A L +GAN +A G T LH++ + ++EM++ LI + A+V+ ++
Sbjct: 955 LENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADN 1010
Score = 73.9 bits (180), Expect = 5e-13
Identities = 62/250 (24%), Positives = 116/250 (46%), Gaps = 8/250 (3%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
++ G TPLH+A +G I L++ ++ D G F A Q + +Q+L N
Sbjct: 844 DDAGWTPLHMAAFEGHRLICEALIEQGARTNEI-DNDGRIPFILASQEGHYDCVQILLEN 902
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGC 267
+ ++Q G L +A G +++V +L A N +G P ++ +Q
Sbjct: 903 K-SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTM 961
Query: 268 AEMIISMDSSQIHSKDPRYGASPLH---WAKNAEMARMLLKRGCNVNSTSSAGNTALHVA 324
AE + + + + + D G + LH W + EM ++L+ +VN+ + +AL A
Sbjct: 962 AEYFLE-NGANVEASDAE-GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ +L+ HGA D G T L +A + ++++++ L+ GA+ + + FG
Sbjct: 1020 AWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGR 1079
Query: 385 TPTFLASKIG 394
T +A+K G
Sbjct: 1080 TAMRVAAKNG 1089
Score = 68.6 bits (166), Expect = 2e-11
Identities = 64/249 (25%), Positives = 114/249 (45%), Gaps = 6/249 (2%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
+ EG T L +A +G+ E++ L+ + + D G T H A + + + L
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDE-NHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A N+++N G P LA Q G + V++LL + + G +G + A +
Sbjct: 870 G-ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDI 928
Query: 268 AEMIISMDSSQIHSKDP--RYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
E++ S + ++ KD R L MA L+ G NV ++ + G TALHV+
Sbjct: 929 VELLFS-HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSC 987
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
+ + VL+ + A+ +A + L A + +V++++ LI GA VD + G T
Sbjct: 988 WQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT 1047
Query: 386 PTFLASKIG 394
+A++ G
Sbjct: 1048 ALCIAAQEG 1056
Score = 65.9 bits (159), Expect = 1e-10
Identities = 60/221 (27%), Positives = 92/221 (41%), Gaps = 12/221 (5%)
Query: 183 DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLC 242
D G T+ A + V+ LL A L + G TPL LA + G ++V L+ C
Sbjct: 542 DSNGRTLLANAAYSGSLDVVNLLVSRG-ADLEIEDAHGHTPLTLAARQGHTKVVNCLIGC 600
Query: 243 NARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIH----SKDPRYGASPLHWAKNAE 298
A N +G+ + + G E++ ++ + + D R W + +
Sbjct: 601 GANINHTDQDGWTALRSAAWG--GHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA- 357
+ LL+ G VN + G TAL A + LL HGA + G T L +A
Sbjct: 659 IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718
Query: 358 ----MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
SK + ++ LI GAEVD + G TP +A+ G
Sbjct: 719 LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEG 759
Score = 53.9 bits (128), Expect = 5e-07
Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 4/137 (2%)
Query: 252 NGYPIHSAMKF---SQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGC 308
NG P+ ++ ++ ++++ + ++S+D R + + R LL G
Sbjct: 478 NGTPVRDSLSTLIPKEQEVLQLLVKA-GAHVNSEDDRTSCIVRQALEREDSIRTLLDNGA 536
Query: 309 NVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKA 368
+VN S G T L A D +L++ GA+ + HG+TPL LA + + +++
Sbjct: 537 SVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNC 596
Query: 369 LIVFGAEVDTPNDFGET 385
LI GA ++ + G T
Sbjct: 597 LIGCGANINHTDQDGWT 613
Score = 44.7 bits (104), Expect = 3e-04
Identities = 28/100 (28%), Positives = 52/100 (52%), Gaps = 2/100 (2%)
Query: 295 KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
K E+ ++L+K G +VNS + + A+ R D LL +GA+ + +G T L
Sbjct: 492 KEQEVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLL 549
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
A +++++ L+ GA+++ + G TP LA++ G
Sbjct: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQG 589
Score = 40.8 bits (94), Expect = 0.005
Identities = 45/197 (22%), Positives = 84/197 (42%), Gaps = 8/197 (4%)
Query: 151 EGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAV 210
+G L +A +G +I VEL+ ++ D G + + + + N
Sbjct: 912 DGRNALRVAALEGHRDI-VELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENG- 969
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIM-GPNGYPIHSAMKFSQKGCAE 269
A + + +G T LH++C G EMV+VL+ +A N + SA +
Sbjct: 970 ANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQ 1029
Query: 270 MIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVM 326
++I + H+ + GA+ L A + ++ ++LL+ G + N G TA+ VA
Sbjct: 1030 LLIEHGAVVDHTCNQ--GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAK 1087
Query: 327 RNRFDCAIVLLTHGANA 343
+L +GA++
Sbjct: 1088 NGHSQIIKLLEKYGASS 1104
Score = 30.8 bits (68), Expect = 4.8
Identities = 23/103 (22%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 151 EGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAV 210
+G T L +A ++G +++ L+++ + D G T A + +SQ+++LL +
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEH-GADPNHADQFGRTAMRVAAKNGHSQIIKLLEK--- 1099
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG 253
G + +N +P+H Q Q + + + N G G
Sbjct: 1100 YGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTG 1142
>gi|52856434 POTE ankyrin domain family, member G [Homo sapiens]
Length = 508
Score = 80.1 bits (196), Expect = 7e-15
Identities = 44/137 (32%), Positives = 78/137 (56%), Gaps = 4/137 (2%)
Query: 256 IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNS 312
+H A + + ++I+ + + ++ KD + + LH A N+E+ ++LL R C +N
Sbjct: 143 LHRAAWWGKVPRKDLIVMLKDTDMNKKD-KQKRTALHLASANGNSEVVKLLLDRRCQLNI 201
Query: 313 TSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVF 372
+ TAL AV +CA++LL HG + + E+GNT LH A+ ++ M KAL+++
Sbjct: 202 LDNKKRTALTKAVQCREDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLY 261
Query: 373 GAEVDTPNDFGETPTFL 389
GA++++ N G TP L
Sbjct: 262 GADIESKNKHGLTPLLL 278
Score = 62.8 bits (151), Expect = 1e-09
Identities = 49/178 (27%), Positives = 77/178 (43%), Gaps = 31/178 (17%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N+ + Q T LHLA G E+V++LL + RC +
Sbjct: 166 MNKKDKQKRTALHLASANGNSEVVKLLL--DRRCQL------------------------ 199
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
I R + + E A MLL+ G + N GNTALH A+
Sbjct: 200 -----NILDNKKRTALTKAVQCREDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLM 254
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 255 AKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILA 312
Score = 50.4 bits (119), Expect = 6e-06
Identities = 53/194 (27%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T M+ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 158 IVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLL-LDRRCQLNILDNKKRTALTKAVQC 216
Query: 231 GKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 217 REDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 274
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G TAL +AV +LL + +
Sbjct: 275 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSS 333
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 334 QDLSGQTAREYAVS 347
>gi|224282147 prostate-specific P704P [Homo sapiens]
Length = 508
Score = 80.1 bits (196), Expect = 7e-15
Identities = 44/137 (32%), Positives = 78/137 (56%), Gaps = 4/137 (2%)
Query: 256 IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNS 312
+H A + + ++I+ + + ++ KD + + LH A N+E+ ++LL R C +N
Sbjct: 143 LHRAAWWGKVPRKDLIVMLKDTDMNKKD-KQKRTALHLASANGNSEVVKLLLDRRCQLNI 201
Query: 313 TSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVF 372
+ TAL AV +CA++LL HG + + E+GNT LH A+ ++ M KAL+++
Sbjct: 202 LDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLY 261
Query: 373 GAEVDTPNDFGETPTFL 389
GA++++ N G TP L
Sbjct: 262 GADIESKNKHGLTPLLL 278
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/178 (27%), Positives = 77/178 (43%), Gaps = 31/178 (17%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N+ + Q T LHLA G E+V++LL + RC +
Sbjct: 166 MNKKDKQKRTALHLASANGNSEVVKLLL--DRRCQL------------------------ 199
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
I R + + E A MLL+ G + N GNTALH A+
Sbjct: 200 -----NILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLM 254
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 255 AKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTVLILA 312
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/194 (26%), Positives = 88/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T M+ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 158 IVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLL-LDRRCQLNILDNKKRTALTKAVQC 216
Query: 231 GKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 217 QEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 274
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G T L +AV +LL + +
Sbjct: 275 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTVLILAVCCGSASIVSLLLEQNIDVSS 333
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 334 QDLSGQTAREYAVS 347
Score = 38.5 bits (88), Expect = 0.023
Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 8/103 (7%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDN---SQVLQLLGRNAV 210
T L A + + E + L+++ T ++ D G T HYA+ ++ ++ L L G
Sbjct: 208 TALTKAVQCQEDECALMLLEH-GTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYG---- 262
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG 253
A + N GLTPL L KQ++V+ L+ A N + G
Sbjct: 263 ADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYG 305
>gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens]
Length = 545
Score = 80.1 bits (196), Expect = 7e-15
Identities = 44/137 (32%), Positives = 78/137 (56%), Gaps = 4/137 (2%)
Query: 256 IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNS 312
+H A + + ++I+ + + ++ KD + + LH A N+E+ ++LL R C +N
Sbjct: 180 LHRAAWWGKVPRKDLIVMLKDTDMNKKD-KQKRTALHLASANGNSEVVKLLLDRRCQLNI 238
Query: 313 TSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVF 372
+ TAL AV +CA++LL HG + + E+GNT LH A+ ++ M KAL+++
Sbjct: 239 LDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLY 298
Query: 373 GAEVDTPNDFGETPTFL 389
GA++++ N G TP L
Sbjct: 299 GADIESKNKHGLTPLLL 315
Score = 62.4 bits (150), Expect = 1e-09
Identities = 49/178 (27%), Positives = 77/178 (43%), Gaps = 31/178 (17%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N+ + Q T LHLA G E+V++LL + RC +
Sbjct: 203 MNKKDKQKRTALHLASANGNSEVVKLLL--DRRCQL------------------------ 236
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
I R + + E A MLL+ G + N GNTALH A+
Sbjct: 237 -----NILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLM 291
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 292 AKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILA 349
Score = 50.4 bits (119), Expect = 6e-06
Identities = 53/194 (27%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T M+ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 195 IVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLL-LDRRCQLNILDNKKRTALTKAVQC 253
Query: 231 GKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 254 QEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 311
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G TAL +AV +LL + +
Sbjct: 312 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSS 370
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 371 QDLSGQTAREYAVS 384
>gi|153791352 prostate, ovary, testis expressed protein on
chromosome 2 [Homo sapiens]
Length = 1075
Score = 80.1 bits (196), Expect = 7e-15
Identities = 45/148 (30%), Positives = 83/148 (56%), Gaps = 4/148 (2%)
Query: 245 RCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMAR 301
R ++ G + +H A + + ++I+ + + ++ +D + + LH A N+E+ +
Sbjct: 132 RYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKQD-KQKRTALHLASANGNSEVVK 190
Query: 302 MLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
+LL R C +N + TAL AV +CA++LL HG + + E+GNT LH A+ +
Sbjct: 191 LLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNE 250
Query: 362 NVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ M KAL+++GA++++ N G TP L
Sbjct: 251 DKLMAKALLLYGADIESKNKHGLTPLLL 278
Score = 59.7 bits (143), Expect = 1e-08
Identities = 50/178 (28%), Positives = 79/178 (44%), Gaps = 31/178 (17%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N+ + Q T LHLA G E+V++LL + RC + + + +K Q C E
Sbjct: 166 VNKQDKQKRTALHLASANGNSEVVKLLL--DRRCQLNVLDNKKRTALIKAVQ--CQE--- 218
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
E A MLL+ G + N GNT LH A+
Sbjct: 219 ------------------------DECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLM 254
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 255 AKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILA 312
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T ++ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 158 IVMLRDTDVNKQDKQKRTALHLASANGNSEVVKLL-LDRRCQLNVLDNKKRTALIKAVQC 216
Query: 231 GKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 217 QEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 274
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G TAL +AV +LL + +
Sbjct: 275 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSS 333
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 334 QDLSGQTAREYAVS 347
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,532,935
Number of Sequences: 37866
Number of extensions: 1291572
Number of successful extensions: 6379
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 338
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 2495
Number of HSP's gapped (non-prelim): 1919
length of query: 752
length of database: 18,247,518
effective HSP length: 110
effective length of query: 642
effective length of database: 14,082,258
effective search space: 9040809636
effective search space used: 9040809636
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.