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Search of human proteins with 52486194
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]
(806 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens] 1638 0.0
gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens] 1476 0.0
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 115 1e-25
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 114 5e-25
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 114 5e-25
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 114 5e-25
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 112 1e-24
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 112 1e-24
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 112 1e-24
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 112 1e-24
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 112 1e-24
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 110 5e-24
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 106 1e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 100 5e-21
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 99 2e-20
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 94 5e-19
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 94 7e-19
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 91 3e-18
gi|30348954 mindbomb homolog 1 [Homo sapiens] 90 9e-18
gi|21264330 mindbomb homolog 2 [Homo sapiens] 87 5e-17
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 87 8e-17
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 86 2e-16
gi|48525351 patatin-like phospholipase domain containing 8 [Homo... 85 3e-16
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 84 5e-16
gi|134133226 protein expressed in prostate, ovary, testis, and p... 82 2e-15
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 82 2e-15
gi|52856434 POTE ankyrin domain family, member G [Homo sapiens] 81 4e-15
gi|224282147 prostate-specific P704P [Homo sapiens] 81 4e-15
gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens] 81 4e-15
gi|153791352 prostate, ovary, testis expressed protein on chromo... 81 4e-15
>gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]
Length = 806
Score = 1638 bits (4241), Expect = 0.0
Identities = 806/806 (100%), Positives = 806/806 (100%)
Query: 1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV 60
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV
Sbjct: 1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV 60
Query: 61 NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW 120
NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW
Sbjct: 61 NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW 120
Query: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD
Sbjct: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
Query: 181 VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL
Sbjct: 181 VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
Query: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA
Sbjct: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
Query: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK
Sbjct: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
Query: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG 420
DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG
Sbjct: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG 420
Query: 421 VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL 480
VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL
Sbjct: 421 VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL 480
Query: 481 LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM 540
LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM
Sbjct: 481 LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM 540
Query: 541 YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR 600
YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR
Sbjct: 541 YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR 600
Query: 601 NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP 660
NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP
Sbjct: 601 NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP 660
Query: 661 TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT 720
TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT
Sbjct: 661 TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT 720
Query: 721 VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN 780
VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN
Sbjct: 721 VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN 780
Query: 781 ALWETEVYIYEHREEFQKLIQLLLSP 806
ALWETEVYIYEHREEFQKLIQLLLSP
Sbjct: 781 ALWETEVYIYEHREEFQKLIQLLLSP 806
>gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]
Length = 752
Score = 1476 bits (3820), Expect = 0.0
Identities = 741/806 (91%), Positives = 744/806 (92%), Gaps = 54/806 (6%)
Query: 1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV 60
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV
Sbjct: 1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLV 60
Query: 61 NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW 120
NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW
Sbjct: 61 NPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSW 120
Query: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD
Sbjct: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
Query: 181 VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL
Sbjct: 181 VTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
Query: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA
Sbjct: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
Query: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK
Sbjct: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
Query: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG 420
DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR +
Sbjct: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQL----------------------- 397
Query: 421 VPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHL 480
+ RA+ P AFILGSMRDEKRTHDHL
Sbjct: 398 ----------QDLMHISRARKP---------------------AFILGSMRDEKRTHDHL 426
Query: 481 LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM 540
LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM
Sbjct: 427 LCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGM 486
Query: 541 YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR 600
YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR
Sbjct: 487 YFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFR 546
Query: 601 NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP 660
NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP
Sbjct: 547 NYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNP 606
Query: 661 TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT 720
TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT
Sbjct: 607 TLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKT 666
Query: 721 VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN 780
VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN
Sbjct: 667 VFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVN 726
Query: 781 ALWETEVYIYEHREEFQKLIQLLLSP 806
ALWETEVYIYEHREEFQKLIQLLLSP
Sbjct: 727 ALWETEVYIYEHREEFQKLIQLLLSP 752
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 115 bits (289), Expect = 1e-25
Identities = 81/275 (29%), Positives = 134/275 (48%), Gaps = 8/275 (2%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
H++ LG + + A G TPLHL+ R+G ++ L+ + + +T
Sbjct: 504 HISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH-GASLSITT 562
Query: 184 YKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCN 243
KG T H A + +V LL + + A + GLTPLH+A Q++ +LL
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKS-ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
Query: 244 ARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEM 299
A + NGY P+H A K +Q A ++ + + R G + +H A + +M
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA--NAVTRQGIASVHLAAQEGHVDM 679
Query: 300 ARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMS 359
+LL R NVN ++ +G T LH+A +R + A VL+ GA+ DA+ + G TPLH+
Sbjct: 680 VSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCH 739
Query: 360 KDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
N++++ L+ A+V+ G TP A++ G
Sbjct: 740 YGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQG 774
Score = 114 bits (284), Expect = 5e-25
Identities = 86/306 (28%), Positives = 149/306 (48%), Gaps = 18/306 (5%)
Query: 124 HLAVELG----IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQM 179
H+A +G + + HH + N G T LH+A R G E++ LVQ Q+
Sbjct: 438 HVAAFMGHVNIVSQLMHHGASPNTTNV----RGETALHMAARSGQAEVVRYLVQD-GAQV 492
Query: 180 DVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
+ +T H + + + ++Q L + A N G TPLHL+ + G +++ L
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQG-ASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Query: 240 LLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK--- 295
L A +I G+ P+H A K+ + A +++ +S + G +PLH A
Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP--DAAGKSGLTPLHVAAHYD 609
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N ++A +LL +G + ++ + G T LH+A +N+ D A LL +GA+A+A G +H
Sbjct: 610 NQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE--Y 413
LA + +V+M+ L+ A V+ N G TP LA++ R+ + ++ V A+
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 414 CFPPIH 419
+ P+H
Sbjct: 730 GYTPLH 735
Score = 109 bits (273), Expect = 9e-24
Identities = 85/307 (27%), Positives = 145/307 (47%), Gaps = 11/307 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ ++ TPLH++ R G +I+ +L+Q + T G T H + + + V L
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATT-SGYTPLHLSAREGHEDVAAFLL 552
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+ A L+ +G TPLH+A + GK E+ +LL +A + G +G P+H A + +
Sbjct: 553 DHG-ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ 611
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALH 322
A +++ +S H+ + G +PLH A ++A LL+ G + N+ + G ++H
Sbjct: 612 KVALLLLDQGASP-HAA-AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+A D +LL AN + + G TPLHLA +D V + + L+ GA VD
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 383 GETPTFLASKIGRLVTRKAILTLLRTVGA--EYCFPPIHGVPAEQGSAAPHHPFSLERAQ 440
G TP + G + +L V A + + P+H A+QG + A
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA-AQQGHTHIINVLLQNNAS 788
Query: 441 PPPISLN 447
P +++N
Sbjct: 789 PNELTVN 795
Score = 109 bits (272), Expect = 1e-23
Identities = 73/254 (28%), Positives = 132/254 (51%), Gaps = 8/254 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TP+H+A G I+ +L+ + + T+ +GET H A + ++V++ L
Sbjct: 428 AVTESGLTPIHVAAFMGHVNIVSQLMHH-GASPNTTNVRGETALHMAARSGQAEVVRYLV 486
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ A + TPLH++ +LGK ++V+ LL A N +GY P+H + + +
Sbjct: 487 QDG-AQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE 545
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
A ++ +S S + G +PLH A E+A +LL++ + ++ +G T LH
Sbjct: 546 DVAAFLLDHGASL--SITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VA + A++LL GA+ A ++G TPLH+A K+ +++ L+ +GA+ +
Sbjct: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQ 663
Query: 383 GETPTFLASKIGRL 396
G LA++ G +
Sbjct: 664 GIASVHLAAQEGHV 677
Score = 104 bits (259), Expect = 4e-22
Identities = 93/319 (29%), Positives = 151/319 (47%), Gaps = 16/319 (5%)
Query: 86 QYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLA--VELGIRECFHHSRIISC 143
Q + P Y ++ Q H EV++ L D N S S+A L + H +++S
Sbjct: 136 QSQNGFTPLYMAA-QENHLEVVKFLLD---NGASQSLATEDGFTPLAVALQQGHDQVVSL 191
Query: 144 A--NCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQV 201
N + + LH+A RK D + L+Q DV G T H A N V
Sbjct: 192 LLENDTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVESKSGFTPLHIAAHYGNINV 250
Query: 202 LQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAM 260
LL N A ++ +TPLH+A + G MV++LL A+ + +G P+H
Sbjct: 251 ATLL-LNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGA 309
Query: 261 KFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAE---MARMLLKRGCNVNSTSSAG 317
+ + EM++ ++ I SK + G SPLH A + ++LL+ V+ ++
Sbjct: 310 RSGHEQVVEMLLDR-AAPILSKT-KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY 367
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
TALHVA + A VLL AN +A+ +G TPLH+A K+ +++++ L+ GA +
Sbjct: 368 LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQ 427
Query: 378 TPNDFGETPTFLASKIGRL 396
+ G TP +A+ +G +
Sbjct: 428 AVTESGLTPIHVAAFMGHV 446
Score = 99.4 bits (246), Expect = 1e-20
Identities = 74/252 (29%), Positives = 126/252 (50%), Gaps = 8/252 (3%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
E++ G TPLH+A G+ + L+ +D T T H A + N+ +++LL
Sbjct: 231 ESKSGFTPLHIAAHYGNINVATLLLNRA-AAVDFTARNDITPLHVASKRGNANMVKLL-L 288
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
+ A ++ GLTPLH + G +++V +LL A NG P+H A +
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 267 CAEMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHV 323
C ++++ + + Y + LH A + ++A++LL + N N+ + G T LH+
Sbjct: 349 CVQLLLQ-HNVPVDDVTNDY-LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A +NR +LL HGA+ A E G TP+H+A +V ++ L+ GA +T N G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 384 ETPTFLASKIGR 395
ET +A++ G+
Sbjct: 467 ETALHMAARSGQ 478
Score = 94.7 bits (234), Expect = 3e-19
Identities = 65/250 (26%), Positives = 114/250 (45%), Gaps = 35/250 (14%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ +G TPLH R G +++ L+ + T G + H A QGD+ +QLL
Sbjct: 296 AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTK-NGLSPLHMATQGDHLNCVQLLL 354
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ V ++ V N LT LH+A G ++ +VLL A N NG+ P+H A K ++
Sbjct: 355 QHNVP-VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNR- 412
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
++ +LLK G ++ + + +G T +HVA
Sbjct: 413 -------------------------------IKVMELLLKHGASIQAVTESGLTPIHVAA 441
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
+ L+ HGA+ + G T LH+A E+++ L+ GA+V+ +T
Sbjct: 442 FMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501
Query: 386 PTFLASKIGR 395
P +++++G+
Sbjct: 502 PLHISARLGK 511
Score = 78.2 bits (191), Expect = 3e-14
Identities = 68/279 (24%), Positives = 127/279 (45%), Gaps = 14/279 (5%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+++ G TPL++A ++ E++ L+ +Q T+ G T A+Q + QV+ LL
Sbjct: 135 AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATE-DGFTPLAVALQQGHDQVVSLLL 193
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
N G + L LH+A + + +LL + ++ +G+ P+H A +
Sbjct: 194 ENDTKGKVR-----LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNI 248
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
A ++++ ++ + R +PLH A NA M ++LL RG +++ + G T LH
Sbjct: 249 NVATLLLNRAAAVDFTA--RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLH 306
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+LL A ++ ++G +PLH+A D++ ++ L+ VD +
Sbjct: 307 CGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTND 366
Query: 383 GETPTFLASKIGRLVTRKAILTLLRTVGAEYC--FPPIH 419
T +A+ G K +L A+ F P+H
Sbjct: 367 YLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLH 405
Score = 78.2 bits (191), Expect = 3e-14
Identities = 71/278 (25%), Positives = 119/278 (42%), Gaps = 9/278 (3%)
Query: 106 VLQHLTDL-IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGD 164
+L H L I ++ H+A + G E + S + A + G TPLH+A +
Sbjct: 551 LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN 610
Query: 165 GEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPL 224
++ + L+ G T H A + + + L A N V QG+ +
Sbjct: 611 QKVALLLLDQ-GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG-ADANAVTRQGIASV 668
Query: 225 HLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKD 283
HLA Q G +MV +LL NA N+ +G P+H A + + AE++++ +
Sbjct: 669 HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV--DAQ 726
Query: 284 PRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHG 340
+ G +PLH N ++ LL+ VN+ + G T LH A + VLL +
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
Query: 341 ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
A+ + +GNT L +A + ++ L + E T
Sbjct: 787 ASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMT 824
Score = 73.2 bits (178), Expect = 9e-13
Identities = 66/279 (23%), Positives = 108/279 (38%), Gaps = 70/279 (25%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G E++ EL+Q
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQ----------------------------------- 95
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A ++ +G T LH+A G+ E+V+VL+ A N NG+ P++ A + +
Sbjct: 96 REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV 155
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWA--------------------------------K 295
+ ++ +SQ S G +PL A
Sbjct: 156 VKFLLDNGASQ--SLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKD 213
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
+ + A +LL+ N + S +G T LH+A + A +LL A D + TPLH
Sbjct: 214 DTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
+A + N M+K L+ GA++D G TP ++ G
Sbjct: 274 VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSG 312
Score = 63.2 bits (152), Expect = 1e-09
Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 3/135 (2%)
Query: 294 AKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTP 353
A + E A +K G ++N + G ALH+A + LL AN DA + GNT
Sbjct: 51 AGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTA 110
Query: 354 LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILT--LLRTVGA 411
LH+A E++K L+ GA V+ + G TP ++A++ L K +L +++
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLAT 170
Query: 412 EYCFPPIHGVPAEQG 426
E F P+ V +QG
Sbjct: 171 EDGFTPL-AVALQQG 184
Score = 53.1 bits (126), Expect = 1e-06
Identities = 60/249 (24%), Positives = 94/249 (37%), Gaps = 67/249 (26%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N N GL LHLA + G E+V LL A + ++KG + I
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAA-------------TKKGNTALHI 113
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
+ + Q AE+ ++L+ G NVN+ S G T L++A N +
Sbjct: 114 ASLAGQ------------------AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV 155
Query: 333 AIVLLTHGANADARGEHGNTP-----------------------------LHLAMSKDNV 363
LL +GA+ E G TP LH+A KD+
Sbjct: 156 VKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDT 215
Query: 364 EMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYC----FPPIH 419
+ L+ D + G TP +A+ G + A L L R ++ P+H
Sbjct: 216 KAAALLLQNDNNADVESKSGFTPLHIAAHYGNI--NVATLLLNRAAAVDFTARNDITPLH 273
Query: 420 GVPAEQGSA 428
V +++G+A
Sbjct: 274 -VASKRGNA 281
Score = 38.1 bits (87), Expect = 0.033
Identities = 30/115 (26%), Positives = 50/115 (43%), Gaps = 1/115 (0%)
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
E R KR + S A + L A + A+ + +G + + ++G LHLA
Sbjct: 23 EKKRKHRKRSRDRKKKSDANASYLRAA-RAGHLEKALDYIKNGVDINICNQNGLNALHLA 81
Query: 358 MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
+ +VE++ L+ A VD G T +AS G+ K ++T V A+
Sbjct: 82 SKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 114 bits (284), Expect = 5e-25
Identities = 79/253 (31%), Positives = 130/253 (51%), Gaps = 10/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH++ R+G ++ L++ + KG T H A + + V +LL
Sbjct: 504 AATTNGYTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+ A + GLTPLH+A Q++ +LL A + NGY P+H A K +Q
Sbjct: 563 QRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 621
Query: 266 GCAEMIISMDS-SQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTAL 321
A +++ + + I +K G +PLH A + +M +LL +G N++ ++ +G T+L
Sbjct: 622 QIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 678
Query: 322 HVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
H+A ++ + A +L HGA+ DA + G TPL +A NV+M+ L+ GA V+
Sbjct: 679 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 738
Query: 382 FGETPTFLASKIG 394
G TP A++ G
Sbjct: 739 NGYTPLHQAAQQG 751
Score = 105 bits (263), Expect = 1e-22
Identities = 90/319 (28%), Positives = 139/319 (43%), Gaps = 14/319 (4%)
Query: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173
IR + +A A ++ + C + + A E + TPLH+A R G EI+ L+Q
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---TPLHIASRLGKTEIVQLLLQ 497
Query: 174 YCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQ 233
+ D G T H + + V +L A A + +G TPLH+A + G
Sbjct: 498 HM-AHPDAATTNGYTPLHISAREGQVDVASVL-LEAGAAHSLATKKGFTPLHVAAKYGSL 555
Query: 234 EMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLH 292
++ ++LL A + G NG P+H A + + A +++ +S + G +PLH
Sbjct: 556 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP--HATAKNGYTPLH 613
Query: 293 WA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEH 349
A ++A LL G N + G T LH+A D +LL GAN +
Sbjct: 614 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673
Query: 350 GNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTV 409
G T LHLA +D V + L GA+ D G TP +A G + +L V
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
Query: 410 GA--EYCFPPIHGVPAEQG 426
A + + P+H A+QG
Sbjct: 734 NAKTKNGYTPLHQA-AQQG 751
Score = 103 bits (258), Expect = 5e-22
Identities = 81/287 (28%), Positives = 138/287 (48%), Gaps = 11/287 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ +G TPLH A R G ++ VEL+ + G + H A QGD+ + ++ L
Sbjct: 273 AKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 331
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ A ++ V LT LH+A G + ++LL A N NG+ P+H A K ++
Sbjct: 332 QHK-APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 390
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
E+++ +S G +P+H A + + +LL+ G + + T+ G TALH
Sbjct: 391 KVMELLVKYGAS--IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 448
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+A + + LL +GA DAR TPLH+A E+++ L+ A D
Sbjct: 449 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 508
Query: 383 GETPTFLASKIGRLVTRKAILT--LLRTVGAEYCFPPIHGVPAEQGS 427
G TP ++++ G++ +L ++ + F P+H V A+ GS
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH-VAAKYGS 554
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/267 (30%), Positives = 124/267 (46%), Gaps = 39/267 (14%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TP+H+A G I++ L+Q DVT+ +GET H A + +V++ L
Sbjct: 405 AITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLL 463
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
RN A ++ + TPLH+A +LGK E+V++LL A + NGY P+H + + Q
Sbjct: 464 RNG-ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ- 521
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
++A +LL+ G + + G T LHVA
Sbjct: 522 -------------------------------VDVASVLLEAGAAHSLATKKGFTPLHVAA 550
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
D A +LL A AD+ G++G TPLH+A DN ++ L+ GA G T
Sbjct: 551 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 610
Query: 386 PTFLASKIGRLVTRKAILTLLRTVGAE 412
P +A+K ++ I + L GAE
Sbjct: 611 PLHIAAKKNQM----QIASTLLNYGAE 633
Score = 94.4 bits (233), Expect = 4e-19
Identities = 69/257 (26%), Positives = 119/257 (46%), Gaps = 18/257 (7%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G ++ EL+ + +D KG T H A ++V+++L +
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 98
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + G TPL++A Q ++V+ LL A + +G+ P+ A++
Sbjct: 99 G-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQA 157
Query: 268 AEMIISMDSS----------QIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAG 317
+++ D+ D + A L NA++ ++ VN T+ +G
Sbjct: 158 VAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM-----VNRTTESG 212
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
T LH+A + A +LL GA D +G TPLH+A + N M+K L+ G ++D
Sbjct: 213 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 272
Query: 378 TPNDFGETPTFLASKIG 394
G TP A++ G
Sbjct: 273 AKTRDGLTPLHCAARSG 289
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/258 (27%), Positives = 124/258 (48%), Gaps = 8/258 (3%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
E G TPLH+A G+ + L+ +D T G T H A + N+ +++LL +
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLL-LDR 267
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
++ GLTPLH A + G ++V +LL A NG P+H A + C
Sbjct: 268 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 327
Query: 269 EMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAV 325
+ ++ + + Y + LH A + + ++LL + N N+ + G T LH+A
Sbjct: 328 KHLLQ-HKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 385
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
+NR +L+ +GA+ A E G TP+H+A ++ ++ L+ GA D N GET
Sbjct: 386 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 445
Query: 386 PTFLASKIGRLVTRKAIL 403
+A++ G++ + +L
Sbjct: 446 ALHMAARAGQVEVVRCLL 463
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/248 (28%), Positives = 122/248 (49%), Gaps = 8/248 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A ++G+ +V+L+ Q+D G T H A + + QV++LL
Sbjct: 245 GITPLHVASKRGNTN-MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 303
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEM 270
L + N GL+PLH+A Q E V+ LL A + + + +H A ++
Sbjct: 304 LLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 362
Query: 271 IISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ D + G +PLH A ++ +L+K G ++ + + +G T +HVA
Sbjct: 363 LL--DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
+ ++LL +GA+ D G T LH+A VE+++ L+ GA VD +TP
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
Query: 388 FLASKIGR 395
+AS++G+
Sbjct: 481 HIASRLGK 488
Score = 93.2 bits (230), Expect = 9e-19
Identities = 75/235 (31%), Positives = 113/235 (48%), Gaps = 12/235 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
+ G TPLH+A + ++ + L++ T G T H A + + Q+ L N
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTL-LNY 630
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCA 268
A N V QG+TPLHLA Q G +MV +LL A ++ +G +H A + + A
Sbjct: 631 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 690
Query: 269 EMIISMDSSQ-IHSKDPRYGASPL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHV 323
+++ + Q H+K G +PL H+ N +M LLK+G NVN+ + G T LH
Sbjct: 691 DILTKHGADQDAHTK---LGYTPLIVACHYG-NVKMVNFLLKQGANVNAKTKNGYTPLHQ 746
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
A + VLL HGA +A +GNT L +A + ++ L V EV T
Sbjct: 747 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 801
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/110 (29%), Positives = 55/110 (50%)
Query: 294 AKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTP 353
A N + LK G ++N+ + G ALH+A LL G++ D+ + GNT
Sbjct: 20 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 79
Query: 354 LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403
LH+A E++K L+ GA ++ + G TP ++A++ + K +L
Sbjct: 80 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 129
Score = 35.8 bits (81), Expect = 0.16
Identities = 22/89 (24%), Positives = 40/89 (44%)
Query: 315 SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
S N + A D + L G + + ++G LHLA + +V +++ L+ G+
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 375 EVDTPNDFGETPTFLASKIGRLVTRKAIL 403
VD+ G T +AS G+ K ++
Sbjct: 68 SVDSATKKGNTALHIASLAGQAEVVKVLV 96
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 114 bits (284), Expect = 5e-25
Identities = 79/253 (31%), Positives = 130/253 (51%), Gaps = 10/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH++ R+G ++ L++ + KG T H A + + V +LL
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+ A + GLTPLH+A Q++ +LL A + NGY P+H A K +Q
Sbjct: 584 QRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
Query: 266 GCAEMIISMDS-SQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTAL 321
A +++ + + I +K G +PLH A + +M +LL +G N++ ++ +G T+L
Sbjct: 643 QIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Query: 322 HVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
H+A ++ + A +L HGA+ DA + G TPL +A NV+M+ L+ GA V+
Sbjct: 700 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 759
Query: 382 FGETPTFLASKIG 394
G TP A++ G
Sbjct: 760 NGYTPLHQAAQQG 772
Score = 105 bits (263), Expect = 1e-22
Identities = 90/319 (28%), Positives = 139/319 (43%), Gaps = 14/319 (4%)
Query: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173
IR + +A A ++ + C + + A E + TPLH+A R G EI+ L+Q
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---TPLHIASRLGKTEIVQLLLQ 518
Query: 174 YCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQ 233
+ D G T H + + V +L A A + +G TPLH+A + G
Sbjct: 519 HM-AHPDAATTNGYTPLHISAREGQVDVASVL-LEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 234 EMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLH 292
++ ++LL A + G NG P+H A + + A +++ +S + G +PLH
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP--HATAKNGYTPLH 634
Query: 293 WA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEH 349
A ++A LL G N + G T LH+A D +LL GAN +
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 350 GNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTV 409
G T LHLA +D V + L GA+ D G TP +A G + +L V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 410 GA--EYCFPPIHGVPAEQG 426
A + + P+H A+QG
Sbjct: 755 NAKTKNGYTPLHQA-AQQG 772
Score = 103 bits (258), Expect = 5e-22
Identities = 81/287 (28%), Positives = 138/287 (48%), Gaps = 11/287 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ +G TPLH A R G ++ VEL+ + G + H A QGD+ + ++ L
Sbjct: 294 AKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ A ++ V LT LH+A G + ++LL A N NG+ P+H A K ++
Sbjct: 353 QHK-APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
E+++ +S G +P+H A + + +LL+ G + + T+ G TALH
Sbjct: 412 KVMELLVKYGAS--IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 469
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+A + + LL +GA DAR TPLH+A E+++ L+ A D
Sbjct: 470 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 529
Query: 383 GETPTFLASKIGRLVTRKAILT--LLRTVGAEYCFPPIHGVPAEQGS 427
G TP ++++ G++ +L ++ + F P+H V A+ GS
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH-VAAKYGS 575
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/267 (30%), Positives = 124/267 (46%), Gaps = 39/267 (14%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TP+H+A G I++ L+Q DVT+ +GET H A + +V++ L
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLL 484
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
RN A ++ + TPLH+A +LGK E+V++LL A + NGY P+H + + Q
Sbjct: 485 RNG-ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ- 542
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
++A +LL+ G + + G T LHVA
Sbjct: 543 -------------------------------VDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
D A +LL A AD+ G++G TPLH+A DN ++ L+ GA G T
Sbjct: 572 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 631
Query: 386 PTFLASKIGRLVTRKAILTLLRTVGAE 412
P +A+K ++ I + L GAE
Sbjct: 632 PLHIAAKKNQM----QIASTLLNYGAE 654
Score = 94.4 bits (233), Expect = 4e-19
Identities = 69/257 (26%), Positives = 119/257 (46%), Gaps = 18/257 (7%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G ++ EL+ + +D KG T H A ++V+++L +
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + G TPL++A Q ++V+ LL A + +G+ P+ A++
Sbjct: 120 G-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQA 178
Query: 268 AEMIISMDSS----------QIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAG 317
+++ D+ D + A L NA++ ++ VN T+ +G
Sbjct: 179 VAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM-----VNRTTESG 233
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
T LH+A + A +LL GA D +G TPLH+A + N M+K L+ G ++D
Sbjct: 234 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 378 TPNDFGETPTFLASKIG 394
G TP A++ G
Sbjct: 294 AKTRDGLTPLHCAARSG 310
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/258 (27%), Positives = 124/258 (48%), Gaps = 8/258 (3%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
E G TPLH+A G+ + L+ +D T G T H A + N+ +++LL +
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLL-LDR 288
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
++ GLTPLH A + G ++V +LL A NG P+H A + C
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
Query: 269 EMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAV 325
+ ++ + + Y + LH A + + ++LL + N N+ + G T LH+A
Sbjct: 349 KHLLQ-HKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 406
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
+NR +L+ +GA+ A E G TP+H+A ++ ++ L+ GA D N GET
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Query: 386 PTFLASKIGRLVTRKAIL 403
+A++ G++ + +L
Sbjct: 467 ALHMAARAGQVEVVRCLL 484
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/248 (28%), Positives = 122/248 (49%), Gaps = 8/248 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A ++G+ +V+L+ Q+D G T H A + + QV++LL
Sbjct: 266 GITPLHVASKRGNTN-MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEM 270
L + N GL+PLH+A Q E V+ LL A + + + +H A ++
Sbjct: 325 LLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 271 IISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ D + G +PLH A ++ +L+K G ++ + + +G T +HVA
Sbjct: 384 LL--DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
+ ++LL +GA+ D G T LH+A VE+++ L+ GA VD +TP
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 388 FLASKIGR 395
+AS++G+
Sbjct: 502 HIASRLGK 509
Score = 93.2 bits (230), Expect = 9e-19
Identities = 75/235 (31%), Positives = 113/235 (48%), Gaps = 12/235 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
+ G TPLH+A + ++ + L++ T G T H A + + Q+ L N
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTL-LNY 651
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCA 268
A N V QG+TPLHLA Q G +MV +LL A ++ +G +H A + + A
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 269 EMIISMDSSQ-IHSKDPRYGASPL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHV 323
+++ + Q H+K G +PL H+ N +M LLK+G NVN+ + G T LH
Sbjct: 712 DILTKHGADQDAHTK---LGYTPLIVACHYG-NVKMVNFLLKQGANVNAKTKNGYTPLHQ 767
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
A + VLL HGA +A +GNT L +A + ++ L V EV T
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/110 (29%), Positives = 55/110 (50%)
Query: 294 AKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTP 353
A N + LK G ++N+ + G ALH+A LL G++ D+ + GNT
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
Query: 354 LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403
LH+A E++K L+ GA ++ + G TP ++A++ + K +L
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150
Score = 35.8 bits (81), Expect = 0.16
Identities = 22/89 (24%), Positives = 40/89 (44%)
Query: 315 SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
S N + A D + L G + + ++G LHLA + +V +++ L+ G+
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 375 EVDTPNDFGETPTFLASKIGRLVTRKAIL 403
VD+ G T +AS G+ K ++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLV 117
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 114 bits (284), Expect = 5e-25
Identities = 79/253 (31%), Positives = 130/253 (51%), Gaps = 10/253 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A G TPLH++ R+G ++ L++ + KG T H A + + V +LL
Sbjct: 525 AATTNGYTPLHISAREGQVDVASVLLE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+ A + GLTPLH+A Q++ +LL A + NGY P+H A K +Q
Sbjct: 584 QRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQM 642
Query: 266 GCAEMIISMDS-SQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTAL 321
A +++ + + I +K G +PLH A + +M +LL +G N++ ++ +G T+L
Sbjct: 643 QIASTLLNYGAETNIVTKQ---GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSL 699
Query: 322 HVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
H+A ++ + A +L HGA+ DA + G TPL +A NV+M+ L+ GA V+
Sbjct: 700 HLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTK 759
Query: 382 FGETPTFLASKIG 394
G TP A++ G
Sbjct: 760 NGYTPLHQAAQQG 772
Score = 105 bits (263), Expect = 1e-22
Identities = 90/319 (28%), Positives = 139/319 (43%), Gaps = 14/319 (4%)
Query: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173
IR + +A A ++ + C + + A E + TPLH+A R G EI+ L+Q
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---TPLHIASRLGKTEIVQLLLQ 518
Query: 174 YCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQ 233
+ D G T H + + V +L A A + +G TPLH+A + G
Sbjct: 519 HM-AHPDAATTNGYTPLHISAREGQVDVASVL-LEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 234 EMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLH 292
++ ++LL A + G NG P+H A + + A +++ +S + G +PLH
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP--HATAKNGYTPLH 634
Query: 293 WA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEH 349
A ++A LL G N + G T LH+A D +LL GAN +
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694
Query: 350 GNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTV 409
G T LHLA +D V + L GA+ D G TP +A G + +L V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 410 GA--EYCFPPIHGVPAEQG 426
A + + P+H A+QG
Sbjct: 755 NAKTKNGYTPLHQA-AQQG 772
Score = 103 bits (258), Expect = 5e-22
Identities = 81/287 (28%), Positives = 138/287 (48%), Gaps = 11/287 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A+ +G TPLH A R G ++ VEL+ + G + H A QGD+ + ++ L
Sbjct: 294 AKTRDGLTPLHCAARSGHDQV-VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
++ A ++ V LT LH+A G + ++LL A N NG+ P+H A K ++
Sbjct: 353 QHK-APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
E+++ +S G +P+H A + + +LL+ G + + T+ G TALH
Sbjct: 412 KVMELLVKYGAS--IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 469
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
+A + + LL +GA DAR TPLH+A E+++ L+ A D
Sbjct: 470 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTN 529
Query: 383 GETPTFLASKIGRLVTRKAILT--LLRTVGAEYCFPPIHGVPAEQGS 427
G TP ++++ G++ +L ++ + F P+H V A+ GS
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH-VAAKYGS 575
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/267 (30%), Positives = 124/267 (46%), Gaps = 39/267 (14%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TP+H+A G I++ L+Q DVT+ +GET H A + +V++ L
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDVTNIRGETALHMAARAGQVEVVRCLL 484
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
RN A ++ + TPLH+A +LGK E+V++LL A + NGY P+H + + Q
Sbjct: 485 RNG-ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ- 542
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
++A +LL+ G + + G T LHVA
Sbjct: 543 -------------------------------VDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
D A +LL A AD+ G++G TPLH+A DN ++ L+ GA G T
Sbjct: 572 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 631
Query: 386 PTFLASKIGRLVTRKAILTLLRTVGAE 412
P +A+K ++ I + L GAE
Sbjct: 632 PLHIAAKKNQM----QIASTLLNYGAE 654
Score = 94.4 bits (233), Expect = 4e-19
Identities = 69/257 (26%), Positives = 119/257 (46%), Gaps = 18/257 (7%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G ++ EL+ + +D KG T H A ++V+++L +
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + G TPL++A Q ++V+ LL A + +G+ P+ A++
Sbjct: 120 G-ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQA 178
Query: 268 AEMIISMDSS----------QIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAG 317
+++ D+ D + A L NA++ ++ VN T+ +G
Sbjct: 179 VAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM-----VNRTTESG 233
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
T LH+A + A +LL GA D +G TPLH+A + N M+K L+ G ++D
Sbjct: 234 FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 378 TPNDFGETPTFLASKIG 394
G TP A++ G
Sbjct: 294 AKTRDGLTPLHCAARSG 310
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/258 (27%), Positives = 124/258 (48%), Gaps = 8/258 (3%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
E G TPLH+A G+ + L+ +D T G T H A + N+ +++LL +
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLL-LDR 288
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
++ GLTPLH A + G ++V +LL A NG P+H A + C
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
Query: 269 EMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAV 325
+ ++ + + Y + LH A + + ++LL + N N+ + G T LH+A
Sbjct: 349 KHLLQ-HKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIAC 406
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
+NR +L+ +GA+ A E G TP+H+A ++ ++ L+ GA D N GET
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466
Query: 386 PTFLASKIGRLVTRKAIL 403
+A++ G++ + +L
Sbjct: 467 ALHMAARAGQVEVVRCLL 484
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/248 (28%), Positives = 122/248 (49%), Gaps = 8/248 (3%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G TPLH+A ++G+ +V+L+ Q+D G T H A + + QV++LL
Sbjct: 266 GITPLHVASKRGNTN-MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEM 270
L + N GL+PLH+A Q E V+ LL A + + + +H A ++
Sbjct: 325 LLARTKN-GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 271 IISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++ D + G +PLH A ++ +L+K G ++ + + +G T +HVA
Sbjct: 384 LL--DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
+ ++LL +GA+ D G T LH+A VE+++ L+ GA VD +TP
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Query: 388 FLASKIGR 395
+AS++G+
Sbjct: 502 HIASRLGK 509
Score = 93.2 bits (230), Expect = 9e-19
Identities = 75/235 (31%), Positives = 113/235 (48%), Gaps = 12/235 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
+ G TPLH+A + ++ + L++ T G T H A + + Q+ L N
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEK-GASPHATAKNGYTPLHIAAKKNQMQIASTL-LNY 651
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCA 268
A N V QG+TPLHLA Q G +MV +LL A ++ +G +H A + + A
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 269 EMIISMDSSQ-IHSKDPRYGASPL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHV 323
+++ + Q H+K G +PL H+ N +M LLK+G NVN+ + G T LH
Sbjct: 712 DILTKHGADQDAHTK---LGYTPLIVACHYG-NVKMVNFLLKQGANVNAKTKNGYTPLHQ 767
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
A + VLL HGA +A +GNT L +A + ++ L V EV T
Sbjct: 768 AAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/110 (29%), Positives = 55/110 (50%)
Query: 294 AKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTP 353
A N + LK G ++N+ + G ALH+A LL G++ D+ + GNT
Sbjct: 41 AGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA 100
Query: 354 LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403
LH+A E++K L+ GA ++ + G TP ++A++ + K +L
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150
Score = 35.8 bits (81), Expect = 0.16
Identities = 22/89 (24%), Positives = 40/89 (44%)
Query: 315 SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
S N + A D + L G + + ++G LHLA + +V +++ L+ G+
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 375 EVDTPNDFGETPTFLASKIGRLVTRKAIL 403
VD+ G T +AS G+ K ++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLV 117
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 490
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 491 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 550 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 607
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 608 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 667
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 668 GVTPLHLAAQEG 679
Score = 109 bits (273), Expect = 9e-24
Identities = 79/247 (31%), Positives = 127/247 (51%), Gaps = 8/247 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 472 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 529
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 590 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 647
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 707
Query: 390 ASKIGRL 396
++ G +
Sbjct: 708 VAQEGHV 714
Score = 108 bits (270), Expect = 2e-23
Identities = 95/311 (30%), Positives = 144/311 (46%), Gaps = 15/311 (4%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
H+A G E + A+ ++ TPLH A R G +V+L+ + ++
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN-MVKLLLENNANPNLAT 533
Query: 184 YKGETVFHYAV-QGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLC 242
G T H A +G VL LL + A + +G TPLH+A + GK + +LL
Sbjct: 534 TAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLHVAAKYGKVRVAELLLER 591
Query: 243 NARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRY-GASPLHWA---KNA 297
+A N G NG P+H A+ + ++++ S HS P + G +PLH A
Sbjct: 592 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HS--PAWNGYTPLHIAAKQNQV 648
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
E+AR LL+ G + N+ S G T LH+A + +LL+ AN + + G TPLHL
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708
Query: 358 MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGA--EYCF 415
+ +V + LI G VD G TP +AS G + K +L V A + +
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768
Query: 416 PPIHGVPAEQG 426
P+H A+QG
Sbjct: 769 SPLHQA-AQQG 778
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/288 (28%), Positives = 135/288 (46%), Gaps = 17/288 (5%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 301 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 359
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 360 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 418
Query: 267 CAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHV 323
E+++ +S + G +PLH A + + + LL+RG + N ++ T LH+
Sbjct: 419 VMELLLKTGASIDAVTES--GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A + A LL + A +A+ + TPLH A + M+K L+ A + G
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 536
Query: 384 ETPTFLASKIGRLVTRKAILTLLRTVGAEYC-----FPPIHGVPAEQG 426
TP +A++ G + T +L LL ++ C F P+H V A+ G
Sbjct: 537 HTPLHIAAREGHVET---VLALLEKEASQACMTKKGFTPLH-VAAKYG 580
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/259 (28%), Positives = 128/259 (49%), Gaps = 12/259 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 132
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 133 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 192
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 193 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 246
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 247 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 306
Query: 385 TPTFLASKIGRLVTRKAIL 403
TP A++ G + + +L
Sbjct: 307 TPLHCAARNGHVRISEILL 325
Score = 97.1 bits (240), Expect = 6e-20
Identities = 78/271 (28%), Positives = 131/271 (48%), Gaps = 14/271 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 567 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 626 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 681
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 801
Query: 385 TPTFLASKIGRLVTRKAILTLLRTVGAEYCF 415
TP +A ++G + ++ +L+ V E F
Sbjct: 802 TPLAIAKRLGYI----SVTDVLKVVTDETSF 828
Score = 93.6 bits (231), Expect = 7e-19
Identities = 84/294 (28%), Positives = 126/294 (42%), Gaps = 41/294 (13%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 210 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 267
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 326
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 327 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 385
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 386 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 445
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
++ ++K L+ GA + N ETP +A++ G K +L V A+
Sbjct: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 499
Score = 84.7 bits (208), Expect = 3e-16
Identities = 81/353 (22%), Positives = 154/353 (43%), Gaps = 75/353 (21%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVT------------------------ 182
A+ + G +P+H+A + + + L+QY D+T
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392
Query: 183 --------DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQE 234
G T H A + ++ +V++LL + A ++ V GLTPLH+A +G
Sbjct: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLP 451
Query: 235 MVRVLLLCNARCNIMGPN-GYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHW 293
+V+ LL A N+ P+H A + A+ ++ + +++++K + +PLH
Sbjct: 452 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL-QNKAKVNAK-AKDDQTPLHC 509
Query: 294 AK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAI---------------- 334
A + M ++LL+ N N ++AG+T LH+A + +
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 335 -----------------VLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
+LL A+ +A G++G TPLH+A+ +N++++K L+ G
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
Query: 378 TPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYC--FPPIHGVPAEQGSA 428
+P G TP +A+K ++ +++L + AE P+H + A++G A
Sbjct: 630 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH-LAAQEGHA 681
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 57 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 116
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILT--LLRTVGAEY 413
+A E+++ L+ +GA V+ + G TP ++A++ L K +L + V E
Sbjct: 117 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 176
Query: 414 CFPPIHGVPAEQG 426
F P+ V +QG
Sbjct: 177 GFTPL-AVALQQG 188
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 458 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 517 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 635 GVTPLHLAAQEG 646
Score = 109 bits (273), Expect = 9e-24
Identities = 79/247 (31%), Positives = 127/247 (51%), Gaps = 8/247 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 496
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 557 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 390 ASKIGRL 396
++ G +
Sbjct: 675 VAQEGHV 681
Score = 108 bits (270), Expect = 2e-23
Identities = 95/311 (30%), Positives = 144/311 (46%), Gaps = 15/311 (4%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
H+A G E + A+ ++ TPLH A R G +V+L+ + ++
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN-MVKLLLENNANPNLAT 500
Query: 184 YKGETVFHYAV-QGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLC 242
G T H A +G VL LL + A + +G TPLH+A + GK + +LL
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLHVAAKYGKVRVAELLLER 558
Query: 243 NARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRY-GASPLHWA---KNA 297
+A N G NG P+H A+ + ++++ S HS P + G +PLH A
Sbjct: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HS--PAWNGYTPLHIAAKQNQV 615
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
E+AR LL+ G + N+ S G T LH+A + +LL+ AN + + G TPLHL
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 358 MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGA--EYCF 415
+ +V + LI G VD G TP +AS G + K +L V A + +
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 416 PPIHGVPAEQG 426
P+H A+QG
Sbjct: 736 SPLHQA-AQQG 745
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/288 (28%), Positives = 135/288 (46%), Gaps = 17/288 (5%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 327 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 267 CAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHV 323
E+++ +S + G +PLH A + + + LL+RG + N ++ T LH+
Sbjct: 386 VMELLLKTGASIDAVTES--GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A + A LL + A +A+ + TPLH A + M+K L+ A + G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 384 ETPTFLASKIGRLVTRKAILTLLRTVGAEYC-----FPPIHGVPAEQG 426
TP +A++ G + T +L LL ++ C F P+H V A+ G
Sbjct: 504 HTPLHIAAREGHVET---VLALLEKEASQACMTKKGFTPLH-VAAKYG 547
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/259 (28%), Positives = 128/259 (49%), Gaps = 12/259 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 99
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 160 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 385 TPTFLASKIGRLVTRKAIL 403
TP A++ G + + +L
Sbjct: 274 TPLHCAARNGHVRISEILL 292
Score = 97.1 bits (240), Expect = 6e-20
Identities = 78/271 (28%), Positives = 131/271 (48%), Gaps = 14/271 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 534 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 593 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 648
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768
Query: 385 TPTFLASKIGRLVTRKAILTLLRTVGAEYCF 415
TP +A ++G + ++ +L+ V E F
Sbjct: 769 TPLAIAKRLGYI----SVTDVLKVVTDETSF 795
Score = 93.6 bits (231), Expect = 7e-19
Identities = 84/294 (28%), Positives = 126/294 (42%), Gaps = 41/294 (13%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 177 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 293
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 294 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
++ ++K L+ GA + N ETP +A++ G K +L V A+
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 84.7 bits (208), Expect = 3e-16
Identities = 81/353 (22%), Positives = 154/353 (43%), Gaps = 75/353 (21%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVT------------------------ 182
A+ + G +P+H+A + + + L+QY D+T
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 183 --------DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQE 234
G T H A + ++ +V++LL + A ++ V GLTPLH+A +G
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLP 418
Query: 235 MVRVLLLCNARCNIMGPN-GYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHW 293
+V+ LL A N+ P+H A + A+ ++ + +++++K + +PLH
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL-QNKAKVNAK-AKDDQTPLHC 476
Query: 294 AK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAI---------------- 334
A + M ++LL+ N N ++AG+T LH+A + +
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 335 -----------------VLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
+LL A+ +A G++G TPLH+A+ +N++++K L+ G
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 378 TPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYC--FPPIHGVPAEQGSA 428
+P G TP +A+K ++ +++L + AE P+H + A++G A
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH-LAAQEGHA 648
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 83
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILT--LLRTVGAEY 413
+A E+++ L+ +GA V+ + G TP ++A++ L K +L + V E
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 143
Query: 414 CFPPIHGVPAEQG 426
F P+ V +QG
Sbjct: 144 GFTPL-AVALQQG 155
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 458 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 517 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 635 GVTPLHLAAQEG 646
Score = 109 bits (273), Expect = 9e-24
Identities = 79/247 (31%), Positives = 127/247 (51%), Gaps = 8/247 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 496
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 557 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 390 ASKIGRL 396
++ G +
Sbjct: 675 VAQEGHV 681
Score = 108 bits (270), Expect = 2e-23
Identities = 95/311 (30%), Positives = 144/311 (46%), Gaps = 15/311 (4%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
H+A G E + A+ ++ TPLH A R G +V+L+ + ++
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN-MVKLLLENNANPNLAT 500
Query: 184 YKGETVFHYAV-QGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLC 242
G T H A +G VL LL + A + +G TPLH+A + GK + +LL
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLHVAAKYGKVRVAELLLER 558
Query: 243 NARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRY-GASPLHWA---KNA 297
+A N G NG P+H A+ + ++++ S HS P + G +PLH A
Sbjct: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HS--PAWNGYTPLHIAAKQNQV 615
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
E+AR LL+ G + N+ S G T LH+A + +LL+ AN + + G TPLHL
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 358 MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGA--EYCF 415
+ +V + LI G VD G TP +AS G + K +L V A + +
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 416 PPIHGVPAEQG 426
P+H A+QG
Sbjct: 736 SPLHQA-AQQG 745
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/288 (28%), Positives = 135/288 (46%), Gaps = 17/288 (5%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 327 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 267 CAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHV 323
E+++ +S + G +PLH A + + + LL+RG + N ++ T LH+
Sbjct: 386 VMELLLKTGASIDAVTES--GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A + A LL + A +A+ + TPLH A + M+K L+ A + G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 384 ETPTFLASKIGRLVTRKAILTLLRTVGAEYC-----FPPIHGVPAEQG 426
TP +A++ G + T +L LL ++ C F P+H V A+ G
Sbjct: 504 HTPLHIAAREGHVET---VLALLEKEASQACMTKKGFTPLH-VAAKYG 547
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/259 (28%), Positives = 128/259 (49%), Gaps = 12/259 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 99
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 160 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 385 TPTFLASKIGRLVTRKAIL 403
TP A++ G + + +L
Sbjct: 274 TPLHCAARNGHVRISEILL 292
Score = 97.1 bits (240), Expect = 6e-20
Identities = 78/271 (28%), Positives = 131/271 (48%), Gaps = 14/271 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 534 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 593 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 648
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768
Query: 385 TPTFLASKIGRLVTRKAILTLLRTVGAEYCF 415
TP +A ++G + ++ +L+ V E F
Sbjct: 769 TPLAIAKRLGYI----SVTDVLKVVTDETSF 795
Score = 93.6 bits (231), Expect = 7e-19
Identities = 84/294 (28%), Positives = 126/294 (42%), Gaps = 41/294 (13%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 177 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 293
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 294 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
++ ++K L+ GA + N ETP +A++ G K +L V A+
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 84.7 bits (208), Expect = 3e-16
Identities = 81/353 (22%), Positives = 154/353 (43%), Gaps = 75/353 (21%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVT------------------------ 182
A+ + G +P+H+A + + + L+QY D+T
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 183 --------DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQE 234
G T H A + ++ +V++LL + A ++ V GLTPLH+A +G
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLP 418
Query: 235 MVRVLLLCNARCNIMGPN-GYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHW 293
+V+ LL A N+ P+H A + A+ ++ + +++++K + +PLH
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL-QNKAKVNAK-AKDDQTPLHC 476
Query: 294 AK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAI---------------- 334
A + M ++LL+ N N ++AG+T LH+A + +
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 335 -----------------VLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
+LL A+ +A G++G TPLH+A+ +N++++K L+ G
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 378 TPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYC--FPPIHGVPAEQGSA 428
+P G TP +A+K ++ +++L + AE P+H + A++G A
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH-LAAQEGHA 648
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 83
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILT--LLRTVGAEY 413
+A E+++ L+ +GA V+ + G TP ++A++ L K +L + V E
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 143
Query: 414 CFPPIHGVPAEQG 426
F P+ V +QG
Sbjct: 144 GFTPL-AVALQQG 155
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 458 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 517 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 635 GVTPLHLAAQEG 646
Score = 109 bits (273), Expect = 9e-24
Identities = 79/247 (31%), Positives = 127/247 (51%), Gaps = 8/247 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 496
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 557 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 390 ASKIGRL 396
++ G +
Sbjct: 675 VAQEGHV 681
Score = 108 bits (270), Expect = 2e-23
Identities = 95/311 (30%), Positives = 144/311 (46%), Gaps = 15/311 (4%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
H+A G E + A+ ++ TPLH A R G +V+L+ + ++
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN-MVKLLLENNANPNLAT 500
Query: 184 YKGETVFHYAV-QGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLC 242
G T H A +G VL LL + A + +G TPLH+A + GK + +LL
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLHVAAKYGKVRVAELLLER 558
Query: 243 NARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRY-GASPLHWA---KNA 297
+A N G NG P+H A+ + ++++ S HS P + G +PLH A
Sbjct: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HS--PAWNGYTPLHIAAKQNQV 615
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
E+AR LL+ G + N+ S G T LH+A + +LL+ AN + + G TPLHL
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 358 MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGA--EYCF 415
+ +V + LI G VD G TP +AS G + K +L V A + +
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 416 PPIHGVPAEQG 426
P+H A+QG
Sbjct: 736 SPLHQA-AQQG 745
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/288 (28%), Positives = 135/288 (46%), Gaps = 17/288 (5%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 327 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 267 CAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHV 323
E+++ +S + G +PLH A + + + LL+RG + N ++ T LH+
Sbjct: 386 VMELLLKTGASIDAVTES--GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A + A LL + A +A+ + TPLH A + M+K L+ A + G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 384 ETPTFLASKIGRLVTRKAILTLLRTVGAEYC-----FPPIHGVPAEQG 426
TP +A++ G + T +L LL ++ C F P+H V A+ G
Sbjct: 504 HTPLHIAAREGHVET---VLALLEKEASQACMTKKGFTPLH-VAAKYG 547
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/259 (28%), Positives = 128/259 (49%), Gaps = 12/259 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 99
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 160 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 385 TPTFLASKIGRLVTRKAIL 403
TP A++ G + + +L
Sbjct: 274 TPLHCAARNGHVRISEILL 292
Score = 97.1 bits (240), Expect = 6e-20
Identities = 78/271 (28%), Positives = 131/271 (48%), Gaps = 14/271 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 534 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 593 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 648
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768
Query: 385 TPTFLASKIGRLVTRKAILTLLRTVGAEYCF 415
TP +A ++G + ++ +L+ V E F
Sbjct: 769 TPLAIAKRLGYI----SVTDVLKVVTDETSF 795
Score = 93.6 bits (231), Expect = 7e-19
Identities = 84/294 (28%), Positives = 126/294 (42%), Gaps = 41/294 (13%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 177 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 293
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 294 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
++ ++K L+ GA + N ETP +A++ G K +L V A+
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 84.7 bits (208), Expect = 3e-16
Identities = 81/353 (22%), Positives = 154/353 (43%), Gaps = 75/353 (21%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVT------------------------ 182
A+ + G +P+H+A + + + L+QY D+T
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 183 --------DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQE 234
G T H A + ++ +V++LL + A ++ V GLTPLH+A +G
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLP 418
Query: 235 MVRVLLLCNARCNIMGPN-GYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHW 293
+V+ LL A N+ P+H A + A+ ++ + +++++K + +PLH
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL-QNKAKVNAK-AKDDQTPLHC 476
Query: 294 AK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAI---------------- 334
A + M ++LL+ N N ++AG+T LH+A + +
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 335 -----------------VLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
+LL A+ +A G++G TPLH+A+ +N++++K L+ G
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 378 TPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYC--FPPIHGVPAEQGSA 428
+P G TP +A+K ++ +++L + AE P+H + A++G A
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH-LAAQEGHA 648
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 83
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILT--LLRTVGAEY 413
+A E+++ L+ +GA V+ + G TP ++A++ L K +L + V E
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 143
Query: 414 CFPPIHGVPAEQG 426
F P+ V +QG
Sbjct: 144 GFTPL-AVALQQG 155
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 112 bits (280), Expect = 1e-24
Identities = 80/252 (31%), Positives = 128/252 (50%), Gaps = 8/252 (3%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A E G TPLH+A G I+ L+Q +V++ K ET H A + +++V + L
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQR-GASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
+N A +N TPLH A ++G MV++LL NA N+ G+ P+H A +
Sbjct: 458 QNK-AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARMLLKRGCNVNSTSSAGNTALH 322
++ ++SQ + G +PLH A +A +LL+R + N+ G T LH
Sbjct: 517 ETVLALLEKEASQACMT--KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDF 382
VAV N D +LL G + + +G TPLH+A ++ VE+ ++L+ +G + +
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Query: 383 GETPTFLASKIG 394
G TP LA++ G
Sbjct: 635 GVTPLHLAAQEG 646
Score = 109 bits (273), Expect = 9e-24
Identities = 79/247 (31%), Positives = 127/247 (51%), Gaps = 8/247 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A R G E+ L+Q +++ +T H A + ++ +++LL N A
Sbjct: 439 TPLHMAARAGHTEVAKYLLQN-KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN-ANP 496
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMII 272
N G TPLH+A + G E V LL A M G+ P+H A K+ + AE+++
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
D+ + + G +PLH A N ++ ++LL RG + +S + G T LH+A +N+
Sbjct: 557 ERDAHP--NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQ 614
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
+ A LL +G +A+A G TPLHLA + + EM+ L+ A + N G TP L
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Query: 390 ASKIGRL 396
++ G +
Sbjct: 675 VAQEGHV 681
Score = 108 bits (270), Expect = 2e-23
Identities = 95/311 (30%), Positives = 144/311 (46%), Gaps = 15/311 (4%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
H+A G E + A+ ++ TPLH A R G +V+L+ + ++
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN-MVKLLLENNANPNLAT 500
Query: 184 YKGETVFHYAV-QGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLC 242
G T H A +G VL LL + A + +G TPLH+A + GK + +LL
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQAC--MTKKGFTPLHVAAKYGKVRVAELLLER 558
Query: 243 NARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRY-GASPLHWA---KNA 297
+A N G NG P+H A+ + ++++ S HS P + G +PLH A
Sbjct: 559 DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP-HS--PAWNGYTPLHIAAKQNQV 615
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
E+AR LL+ G + N+ S G T LH+A + +LL+ AN + + G TPLHL
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675
Query: 358 MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGA--EYCF 415
+ +V + LI G VD G TP +AS G + K +L V A + +
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 416 PPIHGVPAEQG 426
P+H A+QG
Sbjct: 736 SPLHQA-AQQG 745
Score = 99.0 bits (245), Expect = 2e-20
Identities = 82/288 (28%), Positives = 135/288 (46%), Gaps = 17/288 (5%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+ ++ TPLH A R G I L+ + + G + H A QGD+ ++LL +
Sbjct: 268 KTKDELTPLHCAARNGHVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
A ++ + LTPLH+A G + +VLL A+ N NG+ P+H A K +
Sbjct: 327 YD-AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 267 CAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHV 323
E+++ +S + G +PLH A + + + LL+RG + N ++ T LH+
Sbjct: 386 VMELLLKTGASIDAVTES--GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A + A LL + A +A+ + TPLH A + M+K L+ A + G
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG 503
Query: 384 ETPTFLASKIGRLVTRKAILTLLRTVGAEYC-----FPPIHGVPAEQG 426
TP +A++ G + T +L LL ++ C F P+H V A+ G
Sbjct: 504 HTPLHIAAREGHVET---VLALLEKEASQACMTKKGFTPLH-VAAKYG 547
Score = 97.8 bits (242), Expect = 3e-20
Identities = 73/259 (28%), Positives = 128/259 (49%), Gaps = 12/259 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G LHLA ++G +++VEL+ + ++ T KG T H A +V++ L N
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELL-HKEIILETTTKKGNTALHIAALAGQDEVVRELV-N 99
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
A +N + +G TPL++A Q E+V+ LL A N+ +G+ P+ A++ +
Sbjct: 100 YGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENV 159
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+I+ + + LH A + A +LL+ N + S G T LH+A
Sbjct: 160 VAHLIN------YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ A +LL GA+ + ++G TPLH+A + NV M++ L+ GA+++T
Sbjct: 214 AHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL 273
Query: 385 TPTFLASKIGRLVTRKAIL 403
TP A++ G + + +L
Sbjct: 274 TPLHCAARNGHVRISEILL 292
Score = 97.1 bits (240), Expect = 6e-20
Identities = 78/271 (28%), Positives = 131/271 (48%), Gaps = 14/271 (5%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
++G TPLH+A + G + EL+ + G T H AV +N +++LL
Sbjct: 534 KKGFTPLHVAAKYGKVRV-AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
+ + N G TPLH+A + + E+ R LL N G P+H A +Q+G A
Sbjct: 593 GSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA---AQEGHA 648
Query: 269 EMIISMDSSQIHSK-DPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
EM+ + S Q + + G +PLH + +A +L+K G V++T+ G T LHVA
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
LL H A+ +A+ + G +PLH A + + +++ L+ GA + + G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768
Query: 385 TPTFLASKIGRLVTRKAILTLLRTVGAEYCF 415
TP +A ++G + ++ +L+ V E F
Sbjct: 769 TPLAIAKRLGYI----SVTDVLKVVTDETSF 795
Score = 93.6 bits (231), Expect = 7e-19
Identities = 84/294 (28%), Positives = 126/294 (42%), Gaps = 41/294 (13%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH+A R D L+Q DV G T H A +N V QLL N A +N
Sbjct: 177 LHIAARNDDTRTAAVLLQN-DPNPDVLSKTGFTPLHIAAHYENLNVAQLL-LNRGASVNF 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISM 274
G+TPLH+A + G MVR+LL A+ + P+H A + +E+++
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD- 293
Query: 275 DSSQIHSKDPRYGASPLHWAKNAE------------------------------------ 298
+ I +K + G SP+H A +
Sbjct: 294 HGAPIQAKT-KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
+A++LL +G NS + G T LH+A +N +LL GA+ DA E G TPLH+A
Sbjct: 353 VAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
++ ++K L+ GA + N ETP +A++ G K +L V A+
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 84.7 bits (208), Expect = 3e-16
Identities = 81/353 (22%), Positives = 154/353 (43%), Gaps = 75/353 (21%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVT------------------------ 182
A+ + G +P+H+A + + + L+QY D+T
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359
Query: 183 --------DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQE 234
G T H A + ++ +V++LL + A ++ V GLTPLH+A +G
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG-ASIDAVTESGLTPLHVASFMGHLP 418
Query: 235 MVRVLLLCNARCNIMGPN-GYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHW 293
+V+ LL A N+ P+H A + A+ ++ + +++++K + +PLH
Sbjct: 419 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL-QNKAKVNAK-AKDDQTPLHC 476
Query: 294 AK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAI---------------- 334
A + M ++LL+ N N ++AG+T LH+A + +
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 335 -----------------VLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
+LL A+ +A G++G TPLH+A+ +N++++K L+ G
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 378 TPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYC--FPPIHGVPAEQGSA 428
+P G TP +A+K ++ +++L + AE P+H + A++G A
Sbjct: 597 SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLH-LAAQEGHA 648
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/133 (27%), Positives = 62/133 (46%), Gaps = 3/133 (2%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
N + A L+ G ++N+ + G LH+A + LL + + GNT LH
Sbjct: 24 NLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALH 83
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILT--LLRTVGAEY 413
+A E+++ L+ +GA V+ + G TP ++A++ L K +L + V E
Sbjct: 84 IAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATED 143
Query: 414 CFPPIHGVPAEQG 426
F P+ V +QG
Sbjct: 144 GFTPL-AVALQQG 155
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 110 bits (275), Expect = 5e-24
Identities = 85/279 (30%), Positives = 132/279 (47%), Gaps = 9/279 (3%)
Query: 121 SVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMD 180
S+ HLAVE G EC + + N G TPLH+A + + VEL+ ++
Sbjct: 440 SLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGV-VELLLARKISVN 498
Query: 181 VTDYKGETVFHYAVQ-GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVL 239
D T H+A Q GD S LL +NA +N+V+ +G TP+H+ACQ G++ +VR+L
Sbjct: 499 AKDEDQWTALHFAAQNGDESSTRLLLEKNA--SVNEVDFEGRTPMHVACQHGQENIVRIL 556
Query: 240 LLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNA- 297
L ++ G + + P+H A +++ ++++ G +PLH A
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD-GRTPLHLAAQRG 615
Query: 298 --EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
+AR+L+ +VN S T LHVA A +LL GA +A G T LH
Sbjct: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALH 675
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
LA ++ +K L+ A+V +T LA+ G
Sbjct: 676 LAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHG 714
Score = 40.0 bits (92), Expect = 0.009
Identities = 23/86 (26%), Positives = 45/86 (52%)
Query: 309 NVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKA 368
+V+ +G + LH+AV + +CA LL + AN + G+TPLH+A+ + +++
Sbjct: 430 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 489
Query: 369 LIVFGAEVDTPNDFGETPTFLASKIG 394
L+ V+ ++ T A++ G
Sbjct: 490 LLARKISVNAKDEDQWTALHFAAQNG 515
Score = 36.2 bits (82), Expect = 0.12
Identities = 32/102 (31%), Positives = 45/102 (44%), Gaps = 3/102 (2%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A +G T LHLA R G + LV+ + +T H A +S+V++ L
Sbjct: 665 AMTSDGYTALHLAARNGHLATVKLLVEE-KADVLARGPLNQTALHLAAAHGHSEVVEELV 723
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNI 248
V L + QGL+ LHLA Q + V LL A N+
Sbjct: 724 SADVIDL--FDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 106 bits (264), Expect = 1e-22
Identities = 82/264 (31%), Positives = 126/264 (47%), Gaps = 12/264 (4%)
Query: 179 MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV 238
++ D + T H A ++++++LL + A +N +N LTPLH A +E V+V
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSG-ARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 239 LLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK-- 295
L+ +A N N P+H A CAE+II + SS ++ D R G + LH A
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSS-VNVSD-RGGRTALHHAALN 125
Query: 296 -NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
+ EM +LL +G N+N+ ALH A D +L+ HGA + + G TPL
Sbjct: 126 GHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPL 185
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYC 414
H A S + ++K L+ G E+D N +G T +A G + A++ L GA
Sbjct: 186 HAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG----QDAVVNELIDYGANVN 241
Query: 415 FPPIHG-VPAEQGSAAPHHPFSLE 437
P +G P +A+ H LE
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLE 265
Score = 94.0 bits (232), Expect = 5e-19
Identities = 77/264 (29%), Positives = 122/264 (46%), Gaps = 15/264 (5%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
LH A G +++ L+ + ++ D KG T H A V++ L N +++
Sbjct: 152 LHWAAYMGHLDVVALLINH-GAEVTCKDKKGYTPLHAAASNGQINVVKHL-LNLGVEIDE 209
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG-CAEMIIS 273
+N G T LH+AC G+ +V L+ A N NG+ P+H A + C E++++
Sbjct: 210 INVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVN 269
Query: 274 MDSS-QIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
+ I SKD G SPLH ++ L++ G ++ GNT LHVA
Sbjct: 270 NGADVNIQSKD---GKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH 326
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
L T GA+ G H PLHLA + + + L+ G E+DTP+ FG T
Sbjct: 327 ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHA 386
Query: 390 ASKIGRLVTRKAILTLLRTVGAEY 413
A+ G + + LL++ GA++
Sbjct: 387 AAAGGNV----ECIKLLQSSGADF 406
Score = 87.4 bits (215), Expect = 5e-17
Identities = 67/250 (26%), Positives = 116/250 (46%), Gaps = 13/250 (5%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQV-LQLLGR 207
N G T LH+AC G ++ EL+ Y ++ + G T H+A + + L+LL
Sbjct: 211 NVYGNTALHIACYNGQDAVVNELIDY-GANVNQPNNNGFTPLHFAAASTHGALCLELLVN 269
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG 266
N A +N + G +PLH+ G+ + L+ + + +G P+H A ++
Sbjct: 270 NG-ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGH-- 326
Query: 267 CAEMIISM--DSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTAL 321
E++I+ S +K + PLH A +++ R LL G +++ G T L
Sbjct: 327 --ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCL 384
Query: 322 HVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
H A +C +L + GA+ + + G TPLH A + + I+ L+ GA V+ +D
Sbjct: 385 HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
Query: 382 FGETPTFLAS 391
+G T A+
Sbjct: 445 WGRTALHYAA 454
Score = 87.4 bits (215), Expect = 5e-17
Identities = 69/217 (31%), Positives = 109/217 (50%), Gaps = 11/217 (5%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
GCT LH G E + L++ + D +G T HYA ++ L L + A++
Sbjct: 678 GCTALHRGIMTGHEECVQMLLEQ-EVSILCKDSRGRTPLHYAAARGHATWLSELLQMALS 736
Query: 212 GLNQV--NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAE 269
+ +NQG TPLH AC G + + VLL +G P+H A+ CA
Sbjct: 737 EEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCAS 796
Query: 270 MII-SMDSSQIHSKDPRYGASPLH---WAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
+++ ++DSS + +D + G +PL +A + E ++LL+ VN+ ++G TAL +A
Sbjct: 797 LLLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAA 855
Query: 326 MRNRFDCAIVLLTHGANAD--ARGEHGNTPLHLAMSK 360
N A+ +L + A AD + + NTPLHLA SK
Sbjct: 856 -ENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSK 891
Score = 82.0 bits (201), Expect = 2e-15
Identities = 60/219 (27%), Positives = 96/219 (43%), Gaps = 11/219 (5%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N G TPLH A G + +EL+ +++ G++ H Q L +N
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNA---RCNIMGPNGYPIHSAMKFSQK 265
++ V+ G TPLH+A + G + ++ L A +C I +P+H A +
Sbjct: 304 G-GEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM--FPLHLAALNAHS 360
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
C ++S +I + D ++G + LH A N E ++L G + + G T LH
Sbjct: 361 DCCRKLLS-SGFEIDTPD-KFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLH 418
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
A F C L+T GAN + + G T LH A + D
Sbjct: 419 YAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
Score = 75.1 bits (183), Expect = 2e-13
Identities = 90/321 (28%), Positives = 139/321 (43%), Gaps = 26/321 (8%)
Query: 92 LPFYESSPQVLHTEVLQHLTDL-IRNHPSWSVAHLAVELGIRECFHHSRIISCANC--AE 148
L Y Q L +LQ L DL IR+ + LA G EC + I A+ +
Sbjct: 548 LAAYNGHHQALEV-LLQSLVDLDIRDEKGRTALDLAAFKGHTECVE-ALINPGASIFVKD 605
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQ--MDVTDYKGETVFHYAVQGDNSQVLQLLG 206
N TPLH + G L L++ +DV D KG+T AV + + LL
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQK 265
A ++ V+ G T LH G +E V++LL G P+H A + +
Sbjct: 666 EKE-ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA---AAR 721
Query: 266 GCAEMIISMDSSQIHSKD----PRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGN 318
G A + + + +D G +PLHWA N +LL++ C GN
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC---FRKFIGN 778
Query: 319 --TALHVAVMRNRFDCAIVLL--THGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
T LH A++ + +CA +LL + R + G TPL A D+VE ++ L+ A
Sbjct: 779 PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838
Query: 375 EVDTPNDFGETPTFLASKIGR 395
V+ ++ G+T +A++ G+
Sbjct: 839 PVNAVDNSGKTALMMAAENGQ 859
Score = 63.9 bits (154), Expect = 6e-10
Identities = 62/262 (23%), Positives = 106/262 (40%), Gaps = 37/262 (14%)
Query: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCT--PLHLACRKGDGEILVEL 171
IR+ ++ H A G R+C + + E++ G T PLHLA G + L L
Sbjct: 502 IRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVL 561
Query: 172 VQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLG 231
+Q +D+ D KG T A +++ ++ L + + N TPLH + G
Sbjct: 562 LQSL-VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVING 620
Query: 232 KQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPL 291
+R+LL I+ + + KD + G +PL
Sbjct: 621 HTLCLRLLLE------------------------------IADNPEAVDVKDAK-GQTPL 649
Query: 292 HWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGE 348
A + + +LL++ NV++ G TALH +M +C +LL + +
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709
Query: 349 HGNTPLHLAMSKDNVEMIKALI 370
G TPLH A ++ + + L+
Sbjct: 710 RGRTPLHYAAARGHATWLSELL 731
Score = 59.3 bits (142), Expect = 1e-08
Identities = 66/257 (25%), Positives = 106/257 (41%), Gaps = 40/257 (15%)
Query: 155 PLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLN 214
PLHLA + +L+ ++D D G T H A G N + ++LL +++ A +
Sbjct: 350 PLHLAALNAHSDCCRKLLS-SGFEIDTPDKFGRTCLHAAAAGGNVECIKLL-QSSGADFH 407
Query: 215 QVNNQGLTPLHLACQLGKQEMVRVLLLCNARCN-----------------------IMG- 250
+ + G TPLH A + L+ A N I+G
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
Query: 251 --PNGYPIHSAMKFSQKG---CAEMIISMDSS-QIHSKDPRYGASPLHWAK---NAEMAR 301
N + A + +K C E ++ D++ I K+ G + +H+A + +
Sbjct: 468 AHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKE---GYNSIHYAAAYGHRQCLE 524
Query: 302 MLLKRGCN--VNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMS 359
+LL+R + S S A + LH+A VLL + D R E G T L LA
Sbjct: 525 LLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAF 584
Query: 360 KDNVEMIKALIVFGAEV 376
K + E ++ALI GA +
Sbjct: 585 KGHTECVEALINPGASI 601
Score = 57.8 bits (138), Expect = 4e-08
Identities = 63/254 (24%), Positives = 102/254 (40%), Gaps = 11/254 (4%)
Query: 161 RKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQG 220
++ + + +E + + D +G HYA + Q L+LL +G + ++ G
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEE-SDSG 540
Query: 221 LT--PLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFS-QKGCAEMIISMDSS 277
T PLHLA G + + VLL +I G F C E +I+ +S
Sbjct: 541 ATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGAS 600
Query: 278 QIHSKDPRYGASPLHWAK---NAEMARMLLKRGCN---VNSTSSAGNTALHVAVMRNRFD 331
I KD +PLH + + R+LL+ N V+ + G T L +AV D
Sbjct: 601 -IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
Query: 332 CAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLAS 391
+LL AN D G T LH + + E ++ L+ + + G TP A+
Sbjct: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
Query: 392 KIGRLVTRKAILTL 405
G +L +
Sbjct: 720 ARGHATWLSELLQM 733
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/108 (28%), Positives = 55/108 (50%)
Query: 302 MLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
ML+ + +VN+ S T LHVA + +L+ GA +A+ TPLH A++
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 362 NVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTV 409
+ E ++ LI A+V+ + +TP +A+ + + I+ LL +V
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV 108
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/103 (28%), Positives = 49/103 (47%), Gaps = 5/103 (4%)
Query: 138 SRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGD 197
S I+SC +++G TPL A E L L+++ ++ D G+T A +
Sbjct: 804 SSIVSC----RDDKGRTPLRAAAFADHVECLQLLLRHS-APVNAVDNSGKTALMMAAENG 858
Query: 198 NSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLL 240
+ + +L +A A L + TPLHLAC G ++ ++L
Sbjct: 859 QAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 100 bits (249), Expect = 5e-21
Identities = 74/252 (29%), Positives = 121/252 (48%), Gaps = 9/252 (3%)
Query: 183 DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLC 242
D + T H A ++++++LL + A +N +++ LTPLH A +E V+VLL
Sbjct: 38 DNEKRTPLHAAAYLGDAEIIELLILSG-ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKH 96
Query: 243 NARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAE 298
+A N N P+H A CAE ++ + S ++ D R G + LH A + E
Sbjct: 97 SADVNARDKNWQTPLHIAAANKAVKCAEALVPL-LSNVNVSD-RAGRTALHHAAFSGHGE 154
Query: 299 MARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
M ++LL RG N+N+ A+H A + +L++HGA + + TPLH A
Sbjct: 155 MVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAA 214
Query: 359 SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGA--EYCFP 416
S + ++K L+ G +++ PN +G TP +A G+ V ++ V E F
Sbjct: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
Query: 417 PIHGVPAEQGSA 428
P+H A A
Sbjct: 275 PLHFAAASTHGA 286
Score = 99.8 bits (247), Expect = 9e-21
Identities = 79/299 (26%), Positives = 137/299 (45%), Gaps = 14/299 (4%)
Query: 103 HTEVLQHLTD-----LIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLH 157
H EV++ L ++ S++ H A G+ + + N G TPLH
Sbjct: 185 HIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH 244
Query: 158 LACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQV-LQLLGRNAVAGLNQV 216
+AC G ++ EL+ C ++ + KG T H+A + + L+LL N A +N
Sbjct: 245 VACYNGQDVVVNELID-CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNG-ADVNMK 302
Query: 217 NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMD 275
+ G TPLH+ G+ + ++ A + NG P+H A ++ + +I+
Sbjct: 303 SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG 362
Query: 276 SSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
+ +K +G PLH A + + R LL G ++++ G T LH A +C
Sbjct: 363 ADT--AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 420
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLAS 391
+LL GA+ + + + G +PLH A + N + + AL+ GA V+ ++ G TP A+
Sbjct: 421 LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Score = 98.6 bits (244), Expect = 2e-20
Identities = 79/264 (29%), Positives = 121/264 (45%), Gaps = 15/264 (5%)
Query: 156 LHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQ 215
+H A G E++ LV + ++ D K T H A V++ L V +N+
Sbjct: 177 IHWAAYMGHIEVVKLLVSH-GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGV-DMNE 234
Query: 216 VNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKG-CAEMIIS 273
N G TPLH+AC G+ +V L+ C A N G+ P+H A + C E+++
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294
Query: 274 MDSS-QIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
+ + SKD G +PLH ++ +++ G ++ GNT LH+A
Sbjct: 295 NGADVNMKSKD---GKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
L+T GA+ RG HG PLHLA + + L+ G ++DTP+DFG T
Sbjct: 352 ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHA 411
Query: 390 ASKIGRLVTRKAILTLLRTVGAEY 413
A+ G L L LL GA++
Sbjct: 412 AAAGGNL----ECLNLLLNTGADF 431
Score = 86.7 bits (213), Expect = 8e-17
Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 9/219 (4%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHY-AVQGDNSQVLQLLG 206
+NE+G TPLH A G + +EL+ +++ G+T H A+ G S+ ++
Sbjct: 268 KNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQK 265
AV N G TPLH+A + G + ++ L+ A G +G +P+H A
Sbjct: 328 SGAVIDCEDKN--GNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALH 322
C ++S I + D +G + LH A N E +LL G + N G + LH
Sbjct: 386 DCCRKLLS-SGFDIDTPDD-FGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLH 443
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
A + C L+ GA+ + E G TPLH A + D
Sbjct: 444 YAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
Score = 86.3 bits (212), Expect = 1e-16
Identities = 78/294 (26%), Positives = 127/294 (43%), Gaps = 21/294 (7%)
Query: 149 NEEGCTPLHLACRKG-DGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
+E GCTPLH A DG+ L L++ + D +G HY+ + LQL+
Sbjct: 468 DERGCTPLHYAATSDTDGKCLEYLLRN-DANPGIRDKQGYNAVHYSAAYGHRLCLQLIAS 526
Query: 208 NA-------VAGLNQV----NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-P 255
+G + + N ++PLHLA G + + VL+ ++ +G P
Sbjct: 527 ETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTP 586
Query: 256 IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNS 312
+ A C +++I+ +S I KD +P+H A ++E R+L+ N+
Sbjct: 587 LDLAAFKGHVECVDVLINQGAS-ILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNA 645
Query: 313 TS---SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKAL 369
G T L ++V+ DC LL GAN DA+ + G T LH + E + AL
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 370 IVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPA 423
+ GA+ + G TP L++ G + A+L ++ A HG A
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTA 759
Score = 80.5 bits (197), Expect = 6e-15
Identities = 75/263 (28%), Positives = 121/263 (46%), Gaps = 16/263 (6%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQ--MDVTDYKGETVFHYAV-QGDNSQVLQLLGRNAV 210
TP+H A G E L L+ Q +D+ D G+T +V G V LL + A
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA- 677
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAE 269
++ + G T LH G +E V LL A+C + G PIH + G
Sbjct: 678 -NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736
Query: 270 MII----SMDSSQIHSKDPRYGASPLHWA--KNAEMARMLLKRGCNVNSTSSAGNTALHV 323
++ SMD++ + + +G + LHWA E LL T + LH
Sbjct: 737 ALLQSAASMDANPATADN--HGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHC 794
Query: 324 AVMRNRFDCAIVLL-THGAN-ADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPND 381
AV+ + A +L+ T GA+ +A G TPLH A D+VE ++ L+ A+V++ +
Sbjct: 795 AVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDS 854
Query: 382 FGETPTFLASKIGRLVTRKAILT 404
G+TP +A++ G+ T + +++
Sbjct: 855 TGKTPLMMAAENGQTNTVEMLVS 877
Score = 70.5 bits (171), Expect = 6e-12
Identities = 73/268 (27%), Positives = 112/268 (41%), Gaps = 18/268 (6%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHY-AVQGDNSQVLQLLG 206
++ G TPL L+ G + + L+ +D D G T H AV G V LL
Sbjct: 649 QDGNGQTPLMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQ 707
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNI----MGPNGYP-IHSAMK 261
A L +++G TP+HL+ G ++ LL A + +GY +H A
Sbjct: 708 HGAKCLLR--DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACY 765
Query: 262 FSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKR--GCNVNSTSSA 316
+ C E+++ + + K SPLH A N A ML+ VN+T S
Sbjct: 766 NGHETCVELLLEQE---VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK 822
Query: 317 GNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALI-VFGAE 375
G T LH A + +C +LL+H A ++ G TPL +A ++ L+ AE
Sbjct: 823 GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
Query: 376 VDTPNDFGETPTFLASKIGRLVTRKAIL 403
+ ++ T LA G + IL
Sbjct: 883 LTLQDNSKNTALHLACSKGHETSALLIL 910
Score = 68.6 bits (166), Expect = 2e-11
Identities = 89/326 (27%), Positives = 144/326 (44%), Gaps = 21/326 (6%)
Query: 106 VLQHLTD-LIRNHPSWSVAHLAV---ELGIRECFHHSRIISCANCAE-NEEGCTPLHLAC 160
+LQH L+R+ + HL+ +G+ S AN A + G T LH AC
Sbjct: 705 LLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764
Query: 161 RKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL-NQVNNQ 219
G E VEL+ T+ + H AV DN ++L A + N +++
Sbjct: 765 YNGH-ETCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSK 822
Query: 220 GLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQ 278
G TPLH A E +++LL NA+ N + G P+ A + Q EM++S S++
Sbjct: 823 GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
Query: 279 IHSKD-PRYGASPLHWAKNAEMARMLLKRGCN----VNSTSSAGNTALHVAVMRNRFDCA 333
+ +D + A L +K E + +L+ +N+T++A T LHVA
Sbjct: 883 LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVV 942
Query: 334 IVLLTHGANADARGEHGNTP-LHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA-- 390
LL GA+ A E+G TP L A +KD + + ++ V + + TF A
Sbjct: 943 QELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSL-TFNAIN 1001
Query: 391 --SKIGRLVTRKAILTLLRTVGAEYC 414
+ + V+ +A L ++R + YC
Sbjct: 1002 RYTNTSKTVSFEA-LPIMRNEPSSYC 1026
Score = 66.2 bits (160), Expect = 1e-10
Identities = 63/240 (26%), Positives = 98/240 (40%), Gaps = 47/240 (19%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
++N +PLHLA G + L LVQ
Sbjct: 545 SDNRATISPLHLAAYHGHHQALEVLVQ--------------------------------- 571
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPN----GYPIHSAMKF 262
++ L+ N+ G TPL LA G E V VL+ N +I+ + PIH+A
Sbjct: 572 --SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLI--NQGASILVKDYILKRTPIHAAATN 627
Query: 263 SQKGCAEMIISMDSSQ--IHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAG 317
C ++I Q + +D G +PL + + + LL +G NV++ G
Sbjct: 628 GHSECLRLLIGNAEPQNAVDIQDGN-GQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWG 686
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
TALH + +C LL HGA R G TP+HL+ + ++ ++ AL+ A +D
Sbjct: 687 RTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMD 746
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/132 (25%), Positives = 58/132 (43%), Gaps = 10/132 (7%)
Query: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
R L+ + +VN + T LH A + +L+ GA +A+ TPLH A++
Sbjct: 25 RALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVAS 84
Query: 361 DNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHG 420
+ E ++ L+ A+V+ + +TP +A+ + +A++ LL V
Sbjct: 85 CSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNV----------N 134
Query: 421 VPAEQGSAAPHH 432
V G A HH
Sbjct: 135 VSDRAGRTALHH 146
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 98.6 bits (244), Expect = 2e-20
Identities = 92/282 (32%), Positives = 135/282 (47%), Gaps = 22/282 (7%)
Query: 120 WSVAHLAVELGIRECFHHSRIISCANCAEN---EEGCTPLHLACRKGDGEILVELVQYCH 176
W+ HLA + +R++ N EG TPLH+A G LV+L+
Sbjct: 462 WTPLHLAAQNNFENV---ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVS-LVKLLTSQG 517
Query: 177 TQMDVTDYKGETVFHYAVQGDNSQVLQ-LLGRNAVAGLNQVNNQGLTPLHLACQLGKQEM 235
++D T H AV+ + +Q LL AV + ++ G PLH A GK +
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP--DALDQSGYGPLHTAAARGKYLI 575
Query: 236 VRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGA---SPL 291
++LL A + G+ P+H A + KG E+I + S H+ GA +PL
Sbjct: 576 CKMLLRYGASLELPTHQGWTPLHLA---AYKGHLEIIHLLAES--HANMGALGAVNWTPL 630
Query: 292 HWA-KNAEMARM--LLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGE 348
H A ++ E A + LL+ G + N+ +G T LH+AV R+ F I LL H AN AR +
Sbjct: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNK 690
Query: 349 HGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
G TP HLA K N ++K L+ GA++D + TP LA
Sbjct: 691 VGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
Score = 90.5 bits (223), Expect = 6e-18
Identities = 91/335 (27%), Positives = 146/335 (43%), Gaps = 22/335 (6%)
Query: 87 YSSQLLPFYESSPQVLHTEVLQHLTDLIR-NHPSWSVAHLAVELG----IRECFHHSRII 141
Y+ L+ + P L +L H D R + W+ H A + G R H +
Sbjct: 396 YTPLLIAAQDQQPD-LCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACV 454
Query: 142 SCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQV 201
A+ EG TPLHLA + + E + L+ ++ + +G+T H A + +
Sbjct: 455 D----AQEREGWTPLHLAAQN-NFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSL 509
Query: 202 LQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAM 260
++LL A L+ TPLHLA + GK ++ LL A + + +GY P+H+A
Sbjct: 510 VKLLTSQG-AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568
Query: 261 KFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAG 317
+ +M++ +S G +PLH A + E+ +L + N+ + +
Sbjct: 569 ARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN 626
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD 377
T LH+A LL GA+ +A + G TPLHLA+ + + L+ A V
Sbjct: 627 WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 378 TPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
N G TP LA+ G AIL +L GA+
Sbjct: 687 ARNKVGWTPAHLAALKG----NTAILKVLVEAGAQ 717
Score = 88.2 bits (217), Expect = 3e-17
Identities = 73/252 (28%), Positives = 113/252 (44%), Gaps = 10/252 (3%)
Query: 150 EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
E TPLH +G E V L+ +D G T A Q + LL +
Sbjct: 360 ENKVTPLHFLVAQGSVE-QVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHG 418
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268
A N+V+ G PLH A Q G R+LL A + G+ P+H A + + + A
Sbjct: 419 -ADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477
Query: 269 EMIISMDSS-QIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
+++S + +H + G +PLH A + + ++L +G +++ T LH+A
Sbjct: 478 RLLVSRQADPNLHEAE---GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA 534
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
V R + LL GA DA + G PLH A ++ + K L+ +GA ++ P G
Sbjct: 535 VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594
Query: 385 TPTFLASKIGRL 396
TP LA+ G L
Sbjct: 595 TPLHLAAYKGHL 606
Score = 81.3 bits (199), Expect = 3e-15
Identities = 66/221 (29%), Positives = 100/221 (45%), Gaps = 9/221 (4%)
Query: 188 TVFHYAV-QGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARC 246
T H+ V QG QV LL + G TPL +A Q + ++ +LL A
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTAS--GYTPLLIAAQDQQPDLCALLLAHGADA 421
Query: 247 NIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKN---AEMARM 302
N + +G+ P+H A + G A +++ D R G +PLH A +AR+
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLL--DHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 303 LLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDN 362
L+ R + N + G T LHVA +L + GA DA+ + TPLHLA+ +
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 363 VEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403
V I+ L+ GA D + G P A+ G+ + K +L
Sbjct: 540 VRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL 580
Score = 80.9 bits (198), Expect = 4e-15
Identities = 77/287 (26%), Positives = 122/287 (42%), Gaps = 18/287 (6%)
Query: 131 IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVF 190
+R H + C + G TPL +A + ++ L+ + + D G
Sbjct: 378 VRLLLAHEVDVDC----QTASGYTPLLIAAQDQQPDLCALLLAH-GADANRVDEDGWAPL 432
Query: 191 HYAVQ-GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIM 249
H+A Q GD+ LL A + +G TPLHLA Q + + R+L+ A N+
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQE--REGWTPLHLAAQNNFENVARLLVSRQADPNLH 490
Query: 250 GPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARM---LLK 305
G P+H A F +++ S + R +PLH A R LLK
Sbjct: 491 EAEGKTPLHVAAYFGHVSLVKLLTSQGAEL--DAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Query: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEM 365
G ++ +G LH A R ++ +LL +GA+ + G TPLHLA K ++E+
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608
Query: 366 IKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
I L A + TP LA++ G +A+++ L GA+
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHG----EEAVVSALLQCGAD 651
Score = 67.0 bits (162), Expect = 7e-11
Identities = 57/209 (27%), Positives = 90/209 (43%), Gaps = 8/209 (3%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLHLA +G + L++ D D G H A + ++L R A L
Sbjct: 529 TPLHLAVERGKVRAIQHLLK-SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYG-ASL 586
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGP-NGYPIHSAMKFSQKGCAEMII 272
+QG TPLHLA G E++ +L +A +G N P+H A + ++ ++
Sbjct: 587 ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL 646
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARM---LLKRGCNVNSTSSAGNTALHVAVMRNR 329
+ ++ G +PLH A LL+ NV++ + G T H+A ++
Sbjct: 647 QCGADPNAAEQS--GWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGN 704
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAM 358
VL+ GA D + TPL LA+
Sbjct: 705 TAILKVLVEAGAQLDVQDGVSCTPLQLAL 733
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 94.0 bits (232), Expect = 5e-19
Identities = 77/271 (28%), Positives = 127/271 (46%), Gaps = 13/271 (4%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGL 213
TPLH+A + L + ++V D G + H+AV + + + LL N A L
Sbjct: 109 TPLHVAAANRATKCAEALAPLL-SSLNVADRSGRSALHHAVHSGHLETVNLL-LNKGASL 166
Query: 214 NQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPI-HSAMKFSQKGCAEMII 272
N + + PLH A LG E++++L+ A GY + H+A Q + ++
Sbjct: 167 NVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Query: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVA-VMRN 328
M + + +G + LH A +A L+ G NVN + G T LHVA V N
Sbjct: 227 RMGAEI--DEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN 284
Query: 329 RFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTF 388
C +L+ +GA+ + + + G +PLH+A + LI G+E+D + FG TP
Sbjct: 285 GALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLH 344
Query: 389 LASKIGRLVTRKAILTLLRTVGAEYCFPPIH 419
+A++ G + +++ L T GA+ IH
Sbjct: 345 VAARYG----HELLISTLMTNGADTARRGIH 371
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/244 (25%), Positives = 114/244 (46%), Gaps = 16/244 (6%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N++G TPLH+A +G + +EL+ ++ +G++ H A Q+L +N
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGC 267
+ ++ + G TPLH+A + G + ++ L+ A G + +P+H A+ F C
Sbjct: 329 G-SEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDC 387
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
++S S Q++S ++ +L G ++N+ + G T LH A
Sbjct: 388 CRKLLS--SGQLYS------------IVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASG 433
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
+C +LL+ GA+ R + G TPLH A + + + L+ GA V+ + G +P
Sbjct: 434 GNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL 493
Query: 388 FLAS 391
A+
Sbjct: 494 HYAA 497
Score = 83.2 bits (204), Expect = 9e-16
Identities = 65/221 (29%), Positives = 104/221 (47%), Gaps = 7/221 (3%)
Query: 179 MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV 238
++V D + T H A + +LQLL + A +N + LTPLH A ++++ +
Sbjct: 34 INVLDQERRTPLHAAAYVGDVPILQLLLMSG-ANVNAKDTLWLTPLHRAAASRNEKVLGL 92
Query: 239 LLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNA 297
LL +A N P+H A CAE + + SS ++ D R G S LH A ++
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSS-LNVAD-RSGRSALHHAVHS 150
Query: 298 ---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
E +LL +G ++N LH A + +L+ GA+ + G L
Sbjct: 151 GHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLL 210
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
H A + +E++K L+ GAE+D PN FG T +A +G+
Sbjct: 211 HTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
Score = 82.8 bits (203), Expect = 1e-15
Identities = 84/299 (28%), Positives = 128/299 (42%), Gaps = 18/299 (6%)
Query: 106 VLQHLTDLIRNHPSWSVA-HLAVELGIRECFHH-SRIISCANCAENEEGCTPLHLACRKG 163
+L H D+ W H+A +C + ++S N A+ G + LH A G
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS-GRSALHHAVHSG 151
Query: 164 DGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLL-GRNAVAGLNQVNNQGLT 222
E V L+ ++V D K H+A + +VL+LL R A G GL
Sbjct: 152 HLET-VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGL- 209
Query: 223 PLHLACQLGKQEMVRVLLLCNARCNIMGPNGY---PIHSAMKFSQKGCAEMIISMDSSQI 279
LH A G+ E+V+ LL A I PN + +H A Q A +++ ++
Sbjct: 210 -LHTAAASGQIEVVKYLLRMGAE--IDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
Query: 280 HSKDPRYGASPLHWA----KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIV 335
D G +PLH A A +L+ G +VN S G + LH+A + RF + +
Sbjct: 267 QPNDK--GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQI 324
Query: 336 LLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
L+ +G+ D + GNTPLH+A + +I L+ GA+ P LA G
Sbjct: 325 LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFG 383
Score = 82.4 bits (202), Expect = 2e-15
Identities = 91/352 (25%), Positives = 140/352 (39%), Gaps = 68/352 (19%)
Query: 155 PLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLN 214
PLH A G E+L LV + D KG + H A +V++ L R A ++
Sbjct: 176 PLHWAAFLGHLEVLKLLVAR-GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG-AEID 233
Query: 215 QVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPN--GY-PIH-SAMKFSQKGCAEM 270
+ N G T LH+AC LG+ + + L NA N+ PN G+ P+H +A+ + C E+
Sbjct: 234 EPNAFGNTALHIACYLGQDAVA--IELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLEL 291
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMR 327
+++ + + + G SPLH A +++L++ G ++ GNT LHVA
Sbjct: 292 LVNNGADVNYQS--KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY 349
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAM----------------------------- 358
L+T+GA+ RG H PLHLA+
Sbjct: 350 GHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHV 409
Query: 359 ----------------------SKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRL 396
S NVE + L+ GA++ + FG TP A+ G
Sbjct: 410 LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSY 469
Query: 397 VTRKAILTLLRTVGAEYC--FPPIHGVPAEQ--GSAAPHHPFSLERAQPPPI 444
++T V C P+H A A PH P S + + P+
Sbjct: 470 QCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPL 521
Score = 80.5 bits (197), Expect = 6e-15
Identities = 70/248 (28%), Positives = 109/248 (43%), Gaps = 10/248 (4%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
++E TPLH A GD IL +L+ ++ D T H A N +VL LL +
Sbjct: 38 DQERRTPLHAAAYVGDVPIL-QLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAH 96
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGC 267
+ A +N + TPLH+A + L + N+ +G +H A+
Sbjct: 97 S-ADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLET 155
Query: 268 AEMIISMDSS-QIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHV 323
++++ +S + K R PLHWA + E+ ++L+ RG ++ G LH
Sbjct: 156 VNLLLNKGASLNVCDKKER---QPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHT 212
Query: 324 AVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
A + + LL GA D GNT LH+A + L+ GA V+ PND G
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272
Query: 384 ETPTFLAS 391
TP +A+
Sbjct: 273 FTPLHVAA 280
Score = 79.0 bits (193), Expect = 2e-14
Identities = 70/276 (25%), Positives = 115/276 (41%), Gaps = 40/276 (14%)
Query: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGC---TPLHLACRKGDGEILVE 170
+R+ ++ H A G R+ +S NC E+ E +PLHLA G E L
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSF-NCLEDVESTIPVSPLHLAAYNGHCEALKT 603
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
L + +DV D+KG T A + +++ +++L + + L + + TPLH A
Sbjct: 604 LAETL-VNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
Query: 231 GKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASP 290
G + + +L+ R A++ MD+ YG +P
Sbjct: 663 GHTDSLHLLIDSGER----------------------ADITDVMDA---------YGQTP 691
Query: 291 LHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARG 347
L A + + +LL++G ++ G TALH + DC LL H A R
Sbjct: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751
Query: 348 EHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
G TP+HLA + + +++ L+ D P D G
Sbjct: 752 FKGRTPIHLASACGHTAVLRTLLQAALSTD-PLDAG 786
Score = 78.6 bits (192), Expect = 2e-14
Identities = 83/298 (27%), Positives = 131/298 (43%), Gaps = 17/298 (5%)
Query: 125 LAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDY 184
LA+ G +C H A + G T LH G + L L+ + + D+
Sbjct: 694 LAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL-CRDF 752
Query: 185 KGETVFHYAVQGDNSQVLQLLGRNAV------AGLNQVNNQGLTPLHLACQLGKQEMVRV 238
KG T H A ++ VL+ L + A+ AG V+ G +P+H A G ++ + +
Sbjct: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDPLDAG---VDYSGYSPMHWASYTGHEDCLEL 809
Query: 239 LLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLH---WAK 295
LL + + G P+H A+ +Q EM++ ++I + G +PLH +A
Sbjct: 810 LLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFAD 869
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHG-ANADARGEHGNTPL 354
N RMLL+ VN+T G TAL A + LL G A+ E+ NT L
Sbjct: 870 NVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTAL 929
Query: 355 HLAMSKDNVE---MIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTV 409
HLA SK + + MI A ++ N + P +A++ G +A+L+ TV
Sbjct: 930 HLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
Score = 68.6 bits (166), Expect = 2e-11
Identities = 69/251 (27%), Positives = 109/251 (43%), Gaps = 15/251 (5%)
Query: 183 DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQ-GLTPLHLACQLGKQEMVRVLLL 241
D +G T HYA N Q L+LL + L V + ++PLHLA G E ++ L
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
Query: 242 CNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NA 297
++ G + A + C E++ + +S + K+ + +PLH A +
Sbjct: 607 TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL-IKERKRKWTPLHAAAASGHT 665
Query: 298 EMARMLLKRGCNVNSTS---SAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
+ +L+ G + T + G T L +A+M DC +LL G+ ADA G T L
Sbjct: 666 DSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG-----RLVTRKAILTLLRTV 409
H + + AL+ A V + G TP LAS G R + + A+ T
Sbjct: 726 HRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDA 785
Query: 410 GAEYC-FPPIH 419
G +Y + P+H
Sbjct: 786 GVDYSGYSPMH 796
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/183 (25%), Positives = 82/183 (44%), Gaps = 10/183 (5%)
Query: 234 EMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLH 292
E VR LL N++ P+H+A ++++ M + +++KD + +PLH
Sbjct: 22 EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLL-MSGANVNAKDTLW-LTPLH 79
Query: 293 WA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEH 349
A +N ++ +LL +VN+ T LHVA CA L ++ +
Sbjct: 80 RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
Query: 350 GNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTV 409
G + LH A+ ++E + L+ GA ++ + P A+ +G L +L LL
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL----EVLKLLVAR 195
Query: 410 GAE 412
GA+
Sbjct: 196 GAD 198
Score = 48.9 bits (115), Expect = 2e-05
Identities = 36/140 (25%), Positives = 61/140 (43%), Gaps = 10/140 (7%)
Query: 293 WAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNT 352
++++ E R LL + N+N T LH A +LL GAN +A+ T
Sbjct: 17 FSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLT 76
Query: 353 PLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE 412
PLH A + N +++ L+ A+V+ + +TP +A+ +A+ LL ++
Sbjct: 77 PLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSL--- 133
Query: 413 YCFPPIHGVPAEQGSAAPHH 432
V G +A HH
Sbjct: 134 -------NVADRSGRSALHH 146
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 93.6 bits (231), Expect = 7e-19
Identities = 71/213 (33%), Positives = 105/213 (49%), Gaps = 11/213 (5%)
Query: 180 DVTDYKGETVFHYAVQ-GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV 238
DV + T H A Q G++ Q+ QL+ A +NQV +TPLH A G+ V++
Sbjct: 13 DVGFWVERTPVHEAAQRGESLQLQQLIESGAC--VNQVTVDSITPLHAASLQGQARCVQL 70
Query: 239 LLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA--- 294
LL A+ + +G P+ A C ++++S + P Y ASPLH A
Sbjct: 71 LLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKV---NPPLYTASPLHEACMS 127
Query: 295 KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
++E R+L+ G N+ + T LHVA R DC VLL GAN +A H T L
Sbjct: 128 GSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLH-ETAL 186
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPT 387
H A NV++I+ LI FG + ++ G+ P+
Sbjct: 187 HHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPS 219
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 15/181 (8%)
Query: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLG 206
A N +G TPL AC G E + L+ Y +++ Y + H A +S+ ++LL
Sbjct: 80 ARNIDGSTPLCDACASGSIECVKLLLSY-GAKVNPPLYTASPL-HEACMSGSSECVRLL- 136
Query: 207 RNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKG 266
+ A L + TPLH+AC + V+VLL A N + +H A K
Sbjct: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVD 196
Query: 267 CAEMIISMDSSQIHSKDPRYGASP--LHWAKNA--------EMARMLLKRGCNVNSTSSA 316
EM+I I+++D R G P W+ +A E + L + C VN +
Sbjct: 197 LIEMLIEF-GGNIYARDNR-GKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKAT 254
Query: 317 G 317
G
Sbjct: 255 G 255
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/126 (27%), Positives = 57/126 (45%), Gaps = 4/126 (3%)
Query: 289 SPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
+PLH A A ++LL G V++ + G+T L A +C +LL++GA +
Sbjct: 54 TPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNP 113
Query: 346 RGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTL 405
+ +PLH A + E ++ LI GA ++ + TP +A L K +L
Sbjct: 114 P-LYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNA 172
Query: 406 LRTVGA 411
V A
Sbjct: 173 GANVNA 178
Score = 35.8 bits (81), Expect = 0.16
Identities = 29/102 (28%), Positives = 41/102 (40%), Gaps = 1/102 (0%)
Query: 319 TALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDT 378
T +H A R L+ GA + TPLH A + ++ L+ GA+VD
Sbjct: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDA 80
Query: 379 PNDFGETPTFLASKIGRLVTRKAILTLLRTVGAE-YCFPPIH 419
N G TP A G + K +L+ V Y P+H
Sbjct: 81 RNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLH 122
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 91.3 bits (225), Expect = 3e-18
Identities = 70/252 (27%), Positives = 120/252 (47%), Gaps = 8/252 (3%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
N+ G PL +A G+ +IL L++ +++DV D G ++A + + L+ L N
Sbjct: 376 NKHGTPPLLIAAGCGNIQILQLLIKR-GSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGC 267
L+ + G LH+A + G ++ ++L + NI P+H A
Sbjct: 435 KCP-LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSV 493
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVA 324
A+ + + ++ K+ R G +PL A ++ L + G ++N+ G+ ALH+A
Sbjct: 494 AKALCEAGCN-VNIKN-REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
V R + + LL+ G D + HGNTPLH+A N+ ++ AL +D N +G
Sbjct: 552 VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGR 611
Query: 385 TPTFLASKIGRL 396
TP LA+ G L
Sbjct: 612 TPLHLAANNGIL 623
Score = 82.0 bits (201), Expect = 2e-15
Identities = 70/251 (27%), Positives = 114/251 (45%), Gaps = 16/251 (6%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLL-- 205
+++ G ++ A R G + L L + +DV D GE H A + ++ V QLL
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSEN-KCPLDVKDKSGEMALHVAARYGHADVAQLLCS 466
Query: 206 -GRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQ 264
G N N + + TPLH A G + + L C A CN+ N + S
Sbjct: 467 FGSNP----NIQDKEEETPLHCAAWHGYYSVAKAL--CEAGCNVNIKNREGETPLLTASA 520
Query: 265 KGCAEMI--ISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNT 319
+G +++ ++ + +++ D + G LH A E+ + LL +GC V+ GNT
Sbjct: 521 RGYHDIVECLAEHGADLNACD-KDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNT 579
Query: 320 ALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTP 379
LHVA + L N D ++G TPLHLA + +++++ L + GA V+
Sbjct: 580 PLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEAL 639
Query: 380 NDFGETPTFLA 390
G+T LA
Sbjct: 640 TTDGKTAEDLA 650
Score = 64.7 bits (156), Expect = 3e-10
Identities = 56/230 (24%), Positives = 106/230 (46%), Gaps = 16/230 (6%)
Query: 192 YAVQGDNSQVLQ-LLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMG 250
+A+ DN LQ LLG + +NQ N G PL +A G +++++L+ +R ++
Sbjct: 350 HAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQD 409
Query: 251 PNGYPIHSAMKFSQKGCAEMI--ISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLK 305
G ++ ++ G + + +S + + KD + G LH A +A++A++L
Sbjct: 410 KGGS--NAVYWAARHGHVDTLKFLSENKCPLDVKD-KSGEMALHVAARYGHADVAQLLCS 466
Query: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEM 365
G N N T LH A + A L G N + + G TPL A ++ ++
Sbjct: 467 FGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDI 526
Query: 366 IKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCF 415
++ L GA+++ + G LA R+ + +++T+ ++ CF
Sbjct: 527 VECLAEHGADLNACDKDGHIALHLA-------VRRCQMEVIKTLLSQGCF 569
Score = 61.6 bits (148), Expect = 3e-09
Identities = 61/225 (27%), Positives = 95/225 (42%), Gaps = 10/225 (4%)
Query: 143 CANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVL 202
C +++ G LH+A R G ++ L + + ++ D + ET H A V
Sbjct: 436 CPLDVKDKSGEMALHVAARYGHADVAQLLCSF-GSNPNIQDKEEETPLHCAAWHGYYSVA 494
Query: 203 QLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKF 262
+ L A +N N +G TPL A G ++V L A N +G H A+
Sbjct: 495 KALCE-AGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDG---HIALHL 550
Query: 263 SQKGCAEMIISMDSSQIHSKD--PRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAG 317
+ + C +I SQ D R+G +PLH A N + L + CN++ ++ G
Sbjct: 551 AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYG 610
Query: 318 NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDN 362
T LH+A D L GA+ +A G T LA S+ +
Sbjct: 611 RTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQH 655
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 89.7 bits (221), Expect = 9e-18
Identities = 70/243 (28%), Positives = 122/243 (50%), Gaps = 12/243 (4%)
Query: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVA 211
G T + A + G +IL L++ + ++ D G+ H+A GD V+++L R + A
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQ-NVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS-A 521
Query: 212 GLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEM 270
LN N + TPLH+A G ++V+ LL ++ G P+H A+ S+K +
Sbjct: 522 DLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAI--SKKRDDIL 579
Query: 271 IISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLK---RGCNVNSTSSAGNTALHVA 324
+ +++ + G + LH A N R+LL R V+ G TALH+A
Sbjct: 580 AVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 639
Query: 325 VMRNRFDCAIVLLTHG-ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFG 383
+ N + A +L+ G AN D + + T LHLA+ + + ++++ L+ GA++D + G
Sbjct: 640 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDG 699
Query: 384 ETP 386
+TP
Sbjct: 700 DTP 702
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/141 (26%), Positives = 71/141 (50%), Gaps = 4/141 (2%)
Query: 296 NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLH 355
+ ++ ++LLK+ +V + G+ A+H A + VL A+ +AR + TPLH
Sbjct: 476 HVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLH 535
Query: 356 LAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCF 415
+A++K +++++K L+ FG + G+TP L I + R IL +L GA+
Sbjct: 536 IAVNKGHLQVVKTLLDFGCHPSLQDSEGDTP--LHDAISK--KRDDILAVLLEAGADVTI 591
Query: 416 PPIHGVPAEQGSAAPHHPFSL 436
+G A +A +P ++
Sbjct: 592 TNNNGFNALHHAALRGNPSAM 612
Score = 52.0 bits (123), Expect = 2e-06
Identities = 58/250 (23%), Positives = 96/250 (38%), Gaps = 38/250 (15%)
Query: 159 ACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNN 218
A GE L +L++ + D E V A GD ++V LL R V VN
Sbjct: 406 AISNASGERLSQLLKKLFETQESGDLNEELV-KAAANGDVAKVEDLLKRPDV----DVNG 460
Query: 219 Q--GLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDS 276
Q G T + A Q G +++++LL N +G F +G ++ S
Sbjct: 461 QCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGS 520
Query: 277 SQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVL 336
+ +++++ R T LH+AV + L
Sbjct: 521 ADLNARNKRR-------------------------------QTPLHIAVNKGHLQVVKTL 549
Query: 337 LTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRL 396
L G + + G+TPLH A+SK +++ L+ GA+V N+ G A+ G
Sbjct: 550 LDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNP 609
Query: 397 VTRKAILTLL 406
+ +L+ L
Sbjct: 610 SAMRVLLSKL 619
Score = 49.7 bits (117), Expect = 1e-05
Identities = 60/258 (23%), Positives = 103/258 (39%), Gaps = 20/258 (7%)
Query: 115 RNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQY 174
RN + H+AV G + C ++ EG TPLH A K +IL L++
Sbjct: 526 RNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLE- 584
Query: 175 CHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAG--LNQVNNQGLTPLHLACQLGK 232
+ +T+ G H+A N +++L +++ + G T LHLA
Sbjct: 585 AGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNH 644
Query: 233 QEMVRVLL-LCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSS-QIHSKDPRYGAS 289
E+ +L+ NA +I N +H A++ +++ + I KD G +
Sbjct: 645 VEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKD---GDT 701
Query: 290 PLHWAKNAEMARML--LKRGCNVNSTSSAGNTALHVAVM---------RNRFDCAIVLLT 338
PLH A L L+ +V +A + + +M ++ A L
Sbjct: 702 PLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAA 761
Query: 339 HGANADARGEHGNTPLHL 356
+GA+ R + G +PL L
Sbjct: 762 NGADLSIRNKKGQSPLDL 779
>gi|21264330 mindbomb homolog 2 [Homo sapiens]
Length = 1013
Score = 87.4 bits (215), Expect = 5e-17
Identities = 70/250 (28%), Positives = 125/250 (50%), Gaps = 15/250 (6%)
Query: 151 EGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAV 210
+G T L +A G E L+ L+ +D+ D +G T HYA G+ + ++L +A
Sbjct: 522 QGRTALQVAAYLGQVE-LIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVL-LSAG 579
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY---PIHSAMK--FSQK 265
+ +N+ T LH+A Q G E+VR LC C++ P+ + P+HSA+
Sbjct: 580 CRADAINSTQSTALHVAVQRGFLEVVRA--LCERGCDVNLPDAHSDTPLHSAISAGTGAS 637
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCN-VNSTSSAGNTAL 321
G E++ + + + + + + G + LH A +A R +L R V++ G TAL
Sbjct: 638 GIVEVLTEVPNIDVTATNSQ-GFTLLHHASLKGHALAVRKILARARQLVDAKKEDGFTAL 696
Query: 322 HVAVMRNRFDCAIVLLTHG-ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN 380
H+A + N + A +L+ G + + R +PLHLA+ + +V ++ L+ G V+ +
Sbjct: 697 HLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAED 756
Query: 381 DFGETPTFLA 390
+ G+T +A
Sbjct: 757 EEGDTALHVA 766
Score = 64.7 bits (156), Expect = 3e-10
Identities = 74/283 (26%), Positives = 128/283 (45%), Gaps = 36/283 (12%)
Query: 138 SRIISCANC---AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVT--DYKGETVFHY 192
+R++ A C A N T LH+A ++G E++ L C DV D +T H
Sbjct: 572 TRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRAL---CERGCDVNLPDAHSDTPLHS 628
Query: 193 AVQGDN--SQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR-VLLLCNARCNIM 249
A+ S ++++L + N+QG T LH A G VR +L +
Sbjct: 629 AISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAK 688
Query: 250 GPNGYP-IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLK 305
+G+ +H A + + A+++I ++ ++ + SPLH A + + +L+
Sbjct: 689 KEDGFTALHLAALNNHREVAQILIREGRCDVNVRNRKL-QSPLHLAVQQAHVGLVPLLVD 747
Query: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANAD-----------ARGEHGNTPL 354
GC+VN+ G+TALHVA+ R++ + L+ GA D A G G+ L
Sbjct: 748 AGCSVNAEDEEGDTALHVALQRHQL---LPLVADGAGGDPGPLQLLSRLQASGLPGSAEL 804
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLV 397
+ + + L + GA+V N G +P LA++ GR++
Sbjct: 805 TVGAA-----VACFLALEGADVSYTNHRGRSPLDLAAE-GRVL 841
Score = 62.8 bits (151), Expect = 1e-09
Identities = 34/97 (35%), Positives = 54/97 (55%)
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
E+ R+LL+ V+ GNTALH A + N+ + VLL+ G ADA +T LH+A
Sbjct: 537 ELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVA 596
Query: 358 MSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIG 394
+ + +E+++AL G +V+ P+ +TP A G
Sbjct: 597 VQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISAG 633
Score = 61.2 bits (147), Expect = 4e-09
Identities = 63/232 (27%), Positives = 97/232 (41%), Gaps = 45/232 (19%)
Query: 183 DYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVN--NQGLTPLHLACQLGKQEMVRVLL 240
++ G V A+ G+ ++ L LL R QV+ NQG T L +A LG+ E++R+LL
Sbjct: 489 EHPGRLVVEVAL-GNAARALDLLRRRP----EQVDTKNQGRTALQVAAYLGQVELIRLLL 543
Query: 241 LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMA 300
A ++ G ++A+ ++ G E
Sbjct: 544 QARAGVDLPDDEG---NTALHYAALG----------------------------NQPEAT 572
Query: 301 RMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSK 360
R+LL GC ++ +S +TALHVAV R + L G + + H +TPLH A+S
Sbjct: 573 RVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLHSAISA 632
Query: 361 DN-----VEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLR 407
VE++ V +V N G T AS G + + IL R
Sbjct: 633 GTGASGIVEVLTE--VPNIDVTATNSQGFTLLHHASLKGHALAVRKILARAR 682
Score = 46.6 bits (109), Expect = 9e-05
Identities = 38/137 (27%), Positives = 59/137 (43%), Gaps = 2/137 (1%)
Query: 268 AEMIISMDSSQIHSKDPRY-GASPLHWAK-NAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
+ + +++D + DP + G + A NA A LL+R T + G TAL VA
Sbjct: 472 SSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALDLLRRRPEQVDTKNQGRTALQVAA 531
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGET 385
+ + +LL A D + GNT LH A + E + L+ G D N T
Sbjct: 532 YLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQST 591
Query: 386 PTFLASKIGRLVTRKAI 402
+A + G L +A+
Sbjct: 592 ALHVAVQRGFLEVVRAL 608
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 86.7 bits (213), Expect = 8e-17
Identities = 66/235 (28%), Positives = 111/235 (47%), Gaps = 17/235 (7%)
Query: 177 TQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMV 236
+Q D E + A +G V+QL+ + A V G TPLHLA G +V
Sbjct: 2 SQQDAVAALSERLLVAAYKGQTENVVQLINKGARVA---VTKHGRTPLHLAANKGHLPVV 58
Query: 237 RVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHS-----KDPRYGASPL 291
++LL A C++ + + + + G E+I ++ IH + + G + L
Sbjct: 59 QILL--KAGCDLDVQDDGDQTALHRATVVGNTEIIAAL----IHEGCALDRQDKDGNTAL 112
Query: 292 H---WAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGE 348
H W ++ A++L+K G NV + + AGNTALH+A + VLL G+ AD +
Sbjct: 113 HEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNN 172
Query: 349 HGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403
G+T LH+A +++ +I+ L+ V N G+T +A+ + K +L
Sbjct: 173 AGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL 227
Score = 78.2 bits (191), Expect = 3e-14
Identities = 65/246 (26%), Positives = 108/246 (43%), Gaps = 39/246 (15%)
Query: 144 ANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQ 203
A A + G TPLHLA KG + V+++ +DV D +T H A N++++
Sbjct: 34 ARVAVTKHGRTPLHLAANKGHLPV-VQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIA 92
Query: 204 LLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFS 263
L A L++ + G T LH A G + + LL A N++ N
Sbjct: 93 ALIHEGCA-LDRQDKDGNTALHEASWHGFSQSAK--LLVKAGANVLAKN----------- 138
Query: 264 QKGCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTA 320
+ G + LH A +++ R+LL G + ++AG+T
Sbjct: 139 ---------------------KAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTC 177
Query: 321 LHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN 380
LHVA N +LLT + + + G+T LH+A + ++ ++ K L+ GA+ N
Sbjct: 178 LHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVN 237
Query: 381 DFGETP 386
+ G+TP
Sbjct: 238 NAGQTP 243
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 85.5 bits (210), Expect = 2e-16
Identities = 60/187 (32%), Positives = 101/187 (54%), Gaps = 10/187 (5%)
Query: 226 LACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDP 284
LA + G +++R LL ++ G+ PIH A + C +M+I+ DSS+ + K
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 285 RY-GASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHG 340
+ G LH A + ++ ++LL+ G + N+T+ T L +AV + D +LL HG
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 341 ANADARGEH---GNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLV 397
AN + G H G LH A ++N E+IK L+ GA + +DFG TP F+A++ G+L
Sbjct: 136 ANVN--GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
Query: 398 TRKAILT 404
+ +++
Sbjct: 194 SLSILIS 200
Score = 79.0 bits (193), Expect = 2e-14
Identities = 65/251 (25%), Positives = 123/251 (49%), Gaps = 12/251 (4%)
Query: 153 CTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAG 212
C+ + LA R+G+ ++L +L++ + +DV D +G H A ++ + LQ+L NA +
Sbjct: 11 CSTVGLAAREGNVKVLRKLLKKGRS-VDVADNRGWMPIHEAAYHNSVECLQML-INADSS 68
Query: 213 LNQVNN---QGLTPLHLACQLGKQEMVRVLLLCNARCNIMG-PNGYPIHSAMKFSQKGCA 268
N + +G LHLA G ++V++LL A N P+ A++ Q
Sbjct: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
Query: 269 EMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
+++ + ++ G + LH A +NAE+ ++LL++G N G T L VA
Sbjct: 129 RLLLQ-HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA 187
Query: 326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVD--TPNDFG 383
+ + +L++ GAN + + TPL +A + + + ++ L+ GA+ D D
Sbjct: 188 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSW 247
Query: 384 ETPTFLASKIG 394
+ P A+++G
Sbjct: 248 QLPIHAAAQMG 258
Score = 60.5 bits (145), Expect = 6e-09
Identities = 59/239 (24%), Positives = 107/239 (44%), Gaps = 16/239 (6%)
Query: 151 EGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAV 210
E TPL LA G ++L L+Q+ G H A +N+++++LL R
Sbjct: 111 EETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG- 169
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMG-PNGYPIHSAMKFSQKGCAE 269
A ++ G+TPL +A Q GK E + +L+ A N P+ A + C E
Sbjct: 170 ANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVE 229
Query: 270 MIISM--DSSQIHSKD----PRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHV 323
+++S D ++D P + A+ + K ++ L R C+ + ++
Sbjct: 230 LLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVS---PVYS 286
Query: 324 AVMRNRFDCAIVLLTHGANADARG---EHGNTPLHLAMSKD--NVEMIKALIVFGAEVD 377
AV DC +LL +G + DA+ ++P+ +A KD ++ L+ +GA+++
Sbjct: 287 AVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
Score = 40.0 bits (92), Expect = 0.009
Identities = 64/260 (24%), Positives = 107/260 (41%), Gaps = 15/260 (5%)
Query: 65 SQSGFRLFQLELEADALVN---FHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHP--S 119
SQ +++ Q+ LEA A N + + L VL +LQH ++ +H
Sbjct: 88 SQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL-LLQHGANVNGSHSMCG 146
Query: 120 WSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQY-CHTQ 178
W+ H A E +++ G TPL +A + G E L L+ +
Sbjct: 147 WNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVN 206
Query: 179 MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV 238
D K +F A +G V LL A L + P+H A Q+G +++ +
Sbjct: 207 CQALD-KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 265
Query: 239 LL-LCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYG-ASPLHWA-- 294
L+ L N C+ P++SA+ + C E+++ S +G +SP+ A
Sbjct: 266 LIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQ 325
Query: 295 KNAE---MARMLLKRGCNVN 311
K+ E + +LLK G +N
Sbjct: 326 KDCEFFGIVNILLKYGAQIN 345
>gi|48525351 patatin-like phospholipase domain containing 8 [Homo
sapiens]
Length = 782
Score = 84.7 bits (208), Expect = 3e-16
Identities = 111/437 (25%), Positives = 173/437 (39%), Gaps = 78/437 (17%)
Query: 398 TRKAILTLLRTVGAEYCFPPIHGV-------PAEQGSAAPHHPFSLERAQPPPISLNNLE 450
TR + L RT + C + + P +G A ER P + L ++
Sbjct: 363 TRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVK------ERIIPYLLRLRQIK 416
Query: 451 LQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKD 510
+ L + R+ ++G + K +L +DGGG +G++ +Q L + + +
Sbjct: 417 DETLQ--AAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQ 474
Query: 511 LFDWVAGTSTGGILALAI-LHSKSMAYMRGMYFRMKDEVFR------------GSRPYES 557
LFD++ G STG ILA + L + +Y ++ +VF Y+S
Sbjct: 475 LFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDS 534
Query: 558 GPLEEFLKREFGEHTKMTDVRK---PKVMLTGTLSDRQ-PAELHLFRNYDAPETVREPRF 613
E LK G + R PKV T+ +R + +FRNY P
Sbjct: 535 QTWENILKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYG-----HFPGI 589
Query: 614 NQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRP----NGRFLDGGLLANNPTLDAMTEIH 669
N + +W+A R+S AAP YF N DGGLL NNP+ AM E
Sbjct: 590 NSHY-----LGGCQYKMWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALAMHECK 644
Query: 670 EYNQDLIRKGQANKVKKLSIVVSLGTGR-SPQVPVTCVDVFRPSNPWELAKTVFGAKELG 728
D+ L +VSLGTGR V T V S +L+ + A +
Sbjct: 645 CLWPDV----------PLECIVSLGTGRYESDVRNT---VTYTSLKTKLSNVINSATDTE 691
Query: 729 K--MVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETE 786
+ +++D PD YFR NP + +I LDE + L E
Sbjct: 692 EVHIMLDGLLPPD----------------TYFRFNPVMCENIPLDESRNEKLDQLQLEGL 735
Query: 787 VYIYEHREEFQKLIQLL 803
YI + ++ +K+ ++L
Sbjct: 736 KYIERNEQKMKKVAKIL 752
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 84.0 bits (206), Expect = 5e-16
Identities = 66/246 (26%), Positives = 107/246 (43%), Gaps = 41/246 (16%)
Query: 151 EGCTPLHLACR---KGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
EGC + C G E L E + + TD T H+A ++++++ L +
Sbjct: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGC 267
V +N ++ G +PLH+A G+ E+V+ LL A+ N + N
Sbjct: 62 LGVP-VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN--------------- 105
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVA 324
G +PLH+A + E+A MLL+ G N ++ TA+H A
Sbjct: 106 -------------------GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGE 384
+ +LL + A+ + + GNTPLHLA ++ VE K L+ GA + N +
Sbjct: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEK 206
Query: 385 TPTFLA 390
TP +A
Sbjct: 207 TPLQVA 212
Score = 77.4 bits (189), Expect = 5e-14
Identities = 58/186 (31%), Positives = 85/186 (45%), Gaps = 37/186 (19%)
Query: 222 TPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHS 281
T LH AC G E+V LL G P++
Sbjct: 42 TALHWACSAGHTEIVEFLLQL----------GVPVND----------------------- 68
Query: 282 KDPRYGASPLHWAKNA---EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLT 338
KD G SPLH A +A E+ + LL +G VN+ + G T LH A +NR + A++LL
Sbjct: 69 KDDA-GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127
Query: 339 HGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVT 398
GAN DA+ + T +H A +K N++MI L+ + A + + G TP LA R+
Sbjct: 128 GGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEE 187
Query: 399 RKAILT 404
K +++
Sbjct: 188 AKLLVS 193
Score = 63.9 bits (154), Expect = 6e-10
Identities = 58/213 (27%), Positives = 94/213 (44%), Gaps = 41/213 (19%)
Query: 149 NEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRN 208
+++ T LH AC G EI+ L+Q LG
Sbjct: 37 DQDSRTALHWACSAGHTEIVEFLLQ-------------------------------LG-- 63
Query: 209 AVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGC 267
+N ++ G +PLH+A G+ E+V+ LL A+ N + NG P+H A ++
Sbjct: 64 --VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
Query: 268 AEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNSTSSAGNTALHVA 324
A M++ + +KD Y A+ +H A N +M +LL + N + GNT LH+A
Sbjct: 122 AVMLLE-GGANPDAKD-HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
Query: 325 VMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
R + A +L++ GA+ + TPL +A
Sbjct: 180 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/143 (30%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 103 HTEVLQHLTDL-----IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLH 157
HTE+++ L L ++ WS H+A G E A N+ GCTPLH
Sbjct: 52 HTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLH 111
Query: 158 LACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVN 217
A K EI V L++ D D+ T H A N +++ +L A N +
Sbjct: 112 YAASKNRHEIAVMLLE-GGANPDAKDHYEATAMHRAAAKGNLKMIHIL-LYYKASTNIQD 169
Query: 218 NQGLTPLHLACQLGKQEMVRVLL 240
+G TPLHLAC + E ++L+
Sbjct: 170 TEGNTPLHLACDEERVEEAKLLV 192
Score = 45.8 bits (107), Expect = 2e-04
Identities = 31/101 (30%), Positives = 45/101 (44%)
Query: 295 KNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL 354
K E+ +L T TALH A + LL G + + + G +PL
Sbjct: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77
Query: 355 HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGR 395
H+A S E++KAL+ GA+V+ N G TP A+ R
Sbjct: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118
>gi|134133226 protein expressed in prostate, ovary, testis, and
placenta 2 [Homo sapiens]
Length = 1075
Score = 82.4 bits (202), Expect = 2e-15
Identities = 52/175 (29%), Positives = 92/175 (52%), Gaps = 10/175 (5%)
Query: 245 RCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMAR 301
R ++ G + +H A + + ++I+ + + ++ KD + + LH A N+E+ +
Sbjct: 132 RYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKKD-KQKRTALHLASANGNSEVVK 190
Query: 302 MLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
+LL R C +N + TAL AV +CA++LL HG + + E+GNT LH A+ +
Sbjct: 191 LLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNE 250
Query: 362 NVEMIKALIVFGAEVDTPNDFGETPTFLA------SKIGRLVTRKAILTLLRTVG 410
+ M KAL+++GA++++ N G TP L + L+ +KA L L G
Sbjct: 251 DKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYG 305
Score = 64.3 bits (155), Expect = 4e-10
Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 35/220 (15%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N+ + Q T LHLA G E+V++LL + RC + + + +K Q C E
Sbjct: 166 VNKKDKQKRTALHLASANGNSEVVKLLL--DRRCQLNVLDNKKRTALIKAVQ--CQE--- 218
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
E A MLL+ G + N GNT LH A+
Sbjct: 219 ------------------------DECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLM 254
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 255 AKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVC 314
Query: 393 IGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHH 432
G +I++LL + + G A + + + HH
Sbjct: 315 CG----SASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHH 350
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T ++ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 158 IVMLRDTDVNKKDKQKRTALHLASANGNSEVVKLL-LDRRCQLNVLDNKKRTALIKAVQC 216
Query: 231 GKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 217 QEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 274
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G TAL +AV +LL + +
Sbjct: 275 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSS 333
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 334 QDLSGQTAREYAVS 347
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 82.4 bits (202), Expect = 2e-15
Identities = 78/292 (26%), Positives = 130/292 (44%), Gaps = 14/292 (4%)
Query: 124 HLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTD 183
HLA G+ E A++ EG TP+H+A G I+ LV + ++V D
Sbjct: 776 HLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRD 835
Query: 184 YKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCN 243
+G T F A+ N++ + + + QV+N+G LH+A Q E V L+ +
Sbjct: 836 RQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVH 895
Query: 244 ARCNIMGPNG---YPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEM- 299
A N + P+H A++ + ++ + ++ ++ + LH A ++
Sbjct: 896 ANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKV--NELTKHRQTALHLAAQQDLP 953
Query: 300 --ARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTH-GANADARGEHGNTPLHL 356
+LL+ G + + GN ALH+AVM R + VLLT +A+A G +PLH+
Sbjct: 954 TICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNLRGQSPLHI 1013
Query: 357 --AMSKDNVEMIKALIVF---GAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403
K+N I L + G +D P+ G T LA G +AI+
Sbjct: 1014 LGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLCRAIV 1065
Score = 79.0 bits (193), Expect = 2e-14
Identities = 68/254 (26%), Positives = 112/254 (44%), Gaps = 7/254 (2%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGR 207
E +G TPLHLA G E + L+++ ++ D +G T H A+ + ++QLL
Sbjct: 767 EARDGQTPLHLAASWGLEETVQCLLEF-GANVNAQDAEGRTPIHVAISSQHGVIIQLLVS 825
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLL--CNARCNIMGPNGYPIHSAMKFSQK 265
+ LN + QGLTP A + +L A + +H A++ S
Sbjct: 826 HPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDI 885
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAE---MARMLLKRGCNVNSTSSAGNTALH 322
+IS+ ++ +PLH A A + R LL G VN + TALH
Sbjct: 886 ESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALH 945
Query: 323 VAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIV-FGAEVDTPND 381
+A ++ VLL +G + A E+GN LHLA+ + I+ L+ + + N
Sbjct: 946 LAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAEAFNL 1005
Query: 382 FGETPTFLASKIGR 395
G++P + + G+
Sbjct: 1006 RGQSPLHILGQYGK 1019
Score = 74.7 bits (182), Expect = 3e-13
Identities = 76/334 (22%), Positives = 127/334 (38%), Gaps = 91/334 (27%)
Query: 148 ENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGET-----VFHYAVQGDNS--- 199
++ +G TPLH++ G+ + +L+Q +++ D++G T V H V D S
Sbjct: 363 QDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNP 422
Query: 200 -------------------QVLQ---------------LLGRNAVAG------------- 212
+++Q LL R A AG
Sbjct: 423 FEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGA 482
Query: 213 -LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPI--------------- 256
+N N G TPLH AC+ G + LL A N+ P+
Sbjct: 483 HVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVH 542
Query: 257 -----HSAMKFSQKGCAEMIISMDSSQIHSKD-----PRYGASPLH---------WAKNA 297
H A+ ++ +I+ ++ +H+ + P + W
Sbjct: 543 LQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMH 602
Query: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANAD-ARGEHGNTPLHL 356
+A LL G +N T S G T LH+A+ R A+ LL H A+ + +R + G T L L
Sbjct: 603 TIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQL 662
Query: 357 AMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
A+ ++ A+ GA++ P++ G P +LA
Sbjct: 663 AIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLA 696
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/237 (23%), Positives = 97/237 (40%), Gaps = 50/237 (21%)
Query: 151 EGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYK---GETVFHYAVQGDNSQVLQLLGR 207
+G T LH+A ++ D + + L+++ Q D+ + GET A++ V+ +
Sbjct: 621 DGQTLLHMAIQRQDSKSALFLLEH---QADINVSRTQDGETALQLAIRNQLPLVVDAICT 677
Query: 208 NAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLL--CNARCNIMGPNGYPIHSAMKFSQK 265
A ++ + +G PL LA +++ L+ C+A C GP G
Sbjct: 678 RG-ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGG------------ 724
Query: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAG-------- 317
C + ++ + N A L++ GC+VNS G
Sbjct: 725 -CLQTLLHRAIDE----------------NNEPTACFLIRSGCDVNSPRQPGANGEGEEE 767
Query: 318 ----NTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALI 370
T LH+A + LL GAN +A+ G TP+H+A+S + +I+ L+
Sbjct: 768 ARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLV 824
Score = 47.4 bits (111), Expect = 5e-05
Identities = 73/348 (20%), Positives = 128/348 (36%), Gaps = 57/348 (16%)
Query: 104 TEVLQHLTDL-IRNHPSWSVAHLAVELGIRECFHHSRII---SCANCAENEEGCTPLHLA 159
T ++ H D+ + + WS+ H ++ G + F + +I + N A TPLHL
Sbjct: 273 TTLVSHKADVDMVDKSGWSLLHKGIQRG--DLFAATFLIKNGAFVNAATLGAQETPLHLV 330
Query: 160 C----RKGDGEILVELVQYCHTQM------DVTDYKGETVFHYAVQGDNSQVLQLLGRNA 209
+K +++ E+ Q + ++ D KG T H ++ N V L +
Sbjct: 331 ALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCK 390
Query: 210 VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAE 269
L +++G T L LA Q + ++ ++ P+ + F + A
Sbjct: 391 QLDLELKDHEGSTALWLAVQH---------ITVSSDQSVNPFEDVPVVNGTSFDENSFAA 441
Query: 270 MIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNR 329
+I S H+ P C + + AGN A
Sbjct: 442 RLIQRGS---HTDAPDTATG-----------------NCLLQRAAGAGNEA--------- 472
Query: 330 FDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFL 389
A+ L T+GA+ + R + G TPLH A + L+ GA + +
Sbjct: 473 --AALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKE 530
Query: 390 ASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLE 437
A+ + L + T L + Y P + V EQ + A H +L+
Sbjct: 531 AASLTSLADSVHLQTPLH-MAIAYNHPDVVSVILEQKANALHATNNLQ 577
Score = 45.8 bits (107), Expect = 2e-04
Identities = 49/211 (23%), Positives = 89/211 (42%), Gaps = 29/211 (13%)
Query: 155 PLHLACRKGDGEI----LVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAV 210
PLH A + ++ L+E+ +++ D+ G+ A+ + L +
Sbjct: 221 PLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHK- 279
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNI--MGPNGYPIHSAMKFSQKGCA 268
A ++ V+ G + LH Q G L+ A N +G P+H
Sbjct: 280 ADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLH----------- 328
Query: 269 EMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMR- 327
++++ SS+ HS D ++ A++A LL+ G N N S G T LHV++M
Sbjct: 329 --LVALYSSKKHSADVM--------SEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAG 378
Query: 328 NRFDCAIVLLTHGANADARGEHGNTPLHLAM 358
N + + +L + + + G+T L LA+
Sbjct: 379 NEYVFSQLLQCKQLDLELKDHEGSTALWLAV 409
Score = 35.8 bits (81), Expect = 0.16
Identities = 38/154 (24%), Positives = 60/154 (38%), Gaps = 26/154 (16%)
Query: 300 ARMLLKRGCNVNS-TSSAGNTALHVA-----------VMRNRFDCAIVLLTHGANADARG 347
A L+K G VN+ T A T LH+ VM A LL GAN + +
Sbjct: 305 ATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQD 364
Query: 348 EHGNTPLHLAMSKDNVEMIKALI-VFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLL 406
G TPLH+++ N + L+ +++ + G T +LA +
Sbjct: 365 SKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQ-------------H 411
Query: 407 RTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQ 440
TV ++ P VP G++ + F+ Q
Sbjct: 412 ITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQ 445
>gi|52856434 POTE ankyrin domain family, member G [Homo sapiens]
Length = 508
Score = 80.9 bits (198), Expect = 4e-15
Identities = 50/164 (30%), Positives = 87/164 (53%), Gaps = 10/164 (6%)
Query: 256 IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNS 312
+H A + + ++I+ + + ++ KD + + LH A N+E+ ++LL R C +N
Sbjct: 143 LHRAAWWGKVPRKDLIVMLKDTDMNKKD-KQKRTALHLASANGNSEVVKLLLDRRCQLNI 201
Query: 313 TSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVF 372
+ TAL AV +CA++LL HG + + E+GNT LH A+ ++ M KAL+++
Sbjct: 202 LDNKKRTALTKAVQCREDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLY 261
Query: 373 GAEVDTPNDFGETPTFLA------SKIGRLVTRKAILTLLRTVG 410
GA++++ N G TP L + L+ +KA L L G
Sbjct: 262 GADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYG 305
Score = 67.4 bits (163), Expect = 5e-11
Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 35/220 (15%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N+ + Q T LHLA G E+V++LL + RC +
Sbjct: 166 MNKKDKQKRTALHLASANGNSEVVKLLL--DRRCQL------------------------ 199
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
I R + + E A MLL+ G + N GNTALH A+
Sbjct: 200 -----NILDNKKRTALTKAVQCREDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLM 254
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 255 AKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVC 314
Query: 393 IGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHH 432
G +I++LL + + G A + + + HH
Sbjct: 315 CG----SASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHH 350
Score = 50.4 bits (119), Expect = 6e-06
Identities = 53/194 (27%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T M+ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 158 IVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLL-LDRRCQLNILDNKKRTALTKAVQC 216
Query: 231 GKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 217 REDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 274
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G TAL +AV +LL + +
Sbjct: 275 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSS 333
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 334 QDLSGQTAREYAVS 347
Score = 38.9 bits (89), Expect = 0.019
Identities = 44/178 (24%), Positives = 72/178 (40%), Gaps = 45/178 (25%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDN---SQVLQLLGRNAV 210
T L A + + E + L+++ T ++ D G T HYA+ ++ ++ L L G
Sbjct: 208 TALTKAVQCREDECALMLLEH-GTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYG---- 262
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEM 270
A + N GLTPL L KQ++V+ L+ A N +
Sbjct: 263 ADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNAL--------------------- 301
Query: 271 IISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
RYG + L A +A + +LL++ +V+S +G TA AV
Sbjct: 302 -------------DRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAV 346
>gi|224282147 prostate-specific P704P [Homo sapiens]
Length = 508
Score = 80.9 bits (198), Expect = 4e-15
Identities = 50/164 (30%), Positives = 87/164 (53%), Gaps = 10/164 (6%)
Query: 256 IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNS 312
+H A + + ++I+ + + ++ KD + + LH A N+E+ ++LL R C +N
Sbjct: 143 LHRAAWWGKVPRKDLIVMLKDTDMNKKD-KQKRTALHLASANGNSEVVKLLLDRRCQLNI 201
Query: 313 TSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVF 372
+ TAL AV +CA++LL HG + + E+GNT LH A+ ++ M KAL+++
Sbjct: 202 LDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLY 261
Query: 373 GAEVDTPNDFGETPTFLA------SKIGRLVTRKAILTLLRTVG 410
GA++++ N G TP L + L+ +KA L L G
Sbjct: 262 GADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYG 305
Score = 61.2 bits (147), Expect = 4e-09
Identities = 55/221 (24%), Positives = 93/221 (42%), Gaps = 37/221 (16%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIM-GPNGYPIHSAMKFSQKGCAEMI 271
+N+ + Q T LHLA G E+V++LL + NI+ + A++ + CA M
Sbjct: 166 MNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALM- 224
Query: 272 ISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFD 331
LL+ G + N GNTALH A+
Sbjct: 225 -------------------------------LLEHGTDPNIPDEYGNTALHYAIYNEDKL 253
Query: 332 CAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLAS 391
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 254 MAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTVLILAV 313
Query: 392 KIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHH 432
G +I++LL + + G A + + + H
Sbjct: 314 CCG----SASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRH 350
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/194 (26%), Positives = 88/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T M+ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 158 IVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLL-LDRRCQLNILDNKKRTALTKAVQC 216
Query: 231 GKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 217 QEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 274
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G T L +AV +LL + +
Sbjct: 275 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTVLILAVCCGSASIVSLLLEQNIDVSS 333
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 334 QDLSGQTAREYAVS 347
Score = 38.5 bits (88), Expect = 0.025
Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 8/103 (7%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDN---SQVLQLLGRNAV 210
T L A + + E + L+++ T ++ D G T HYA+ ++ ++ L L G
Sbjct: 208 TALTKAVQCQEDECALMLLEH-GTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYG---- 262
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNG 253
A + N GLTPL L KQ++V+ L+ A N + G
Sbjct: 263 ADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYG 305
>gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens]
Length = 545
Score = 80.9 bits (198), Expect = 4e-15
Identities = 50/164 (30%), Positives = 87/164 (53%), Gaps = 10/164 (6%)
Query: 256 IHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMARMLLKRGCNVNS 312
+H A + + ++I+ + + ++ KD + + LH A N+E+ ++LL R C +N
Sbjct: 180 LHRAAWWGKVPRKDLIVMLKDTDMNKKD-KQKRTALHLASANGNSEVVKLLLDRRCQLNI 238
Query: 313 TSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVF 372
+ TAL AV +CA++LL HG + + E+GNT LH A+ ++ M KAL+++
Sbjct: 239 LDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLY 298
Query: 373 GAEVDTPNDFGETPTFLA------SKIGRLVTRKAILTLLRTVG 410
GA++++ N G TP L + L+ +KA L L G
Sbjct: 299 GADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYG 342
Score = 61.6 bits (148), Expect = 3e-09
Identities = 55/221 (24%), Positives = 93/221 (42%), Gaps = 37/221 (16%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIM-GPNGYPIHSAMKFSQKGCAEMI 271
+N+ + Q T LHLA G E+V++LL + NI+ + A++ + CA M
Sbjct: 203 MNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALM- 261
Query: 272 ISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFD 331
LL+ G + N GNTALH A+
Sbjct: 262 -------------------------------LLEHGTDPNIPDEYGNTALHYAIYNEDKL 290
Query: 332 CAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLAS 391
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 291 MAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAV 350
Query: 392 KIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHH 432
G +I++LL + + G A + + + H
Sbjct: 351 CCG----SASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRH 387
Score = 50.4 bits (119), Expect = 6e-06
Identities = 53/194 (27%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T M+ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 195 IVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLL-LDRRCQLNILDNKKRTALTKAVQC 253
Query: 231 GKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 254 QEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 311
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G TAL +AV +LL + +
Sbjct: 312 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSS 370
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 371 QDLSGQTAREYAVS 384
Score = 38.9 bits (89), Expect = 0.019
Identities = 44/178 (24%), Positives = 72/178 (40%), Gaps = 45/178 (25%)
Query: 154 TPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDN---SQVLQLLGRNAV 210
T L A + + E + L+++ T ++ D G T HYA+ ++ ++ L L G
Sbjct: 245 TALTKAVQCQEDECALMLLEH-GTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYG---- 299
Query: 211 AGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEM 270
A + N GLTPL L KQ++V+ L+ A N +
Sbjct: 300 ADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNAL--------------------- 338
Query: 271 IISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
RYG + L A +A + +LL++ +V+S +G TA AV
Sbjct: 339 -------------DRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAV 383
>gi|153791352 prostate, ovary, testis expressed protein on
chromosome 2 [Homo sapiens]
Length = 1075
Score = 80.9 bits (198), Expect = 4e-15
Identities = 51/175 (29%), Positives = 92/175 (52%), Gaps = 10/175 (5%)
Query: 245 RCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAK---NAEMAR 301
R ++ G + +H A + + ++I+ + + ++ +D + + LH A N+E+ +
Sbjct: 132 RYHVRGEDLDKLHRAAWWGKVPRKDLIVMLRDTDVNKQD-KQKRTALHLASANGNSEVVK 190
Query: 302 MLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKD 361
+LL R C +N + TAL AV +CA++LL HG + + E+GNT LH A+ +
Sbjct: 191 LLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNE 250
Query: 362 NVEMIKALIVFGAEVDTPNDFGETPTFLA------SKIGRLVTRKAILTLLRTVG 410
+ M KAL+++GA++++ N G TP L + L+ +KA L L G
Sbjct: 251 DKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYG 305
Score = 64.3 bits (155), Expect = 4e-10
Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 35/220 (15%)
Query: 213 LNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMII 272
+N+ + Q T LHLA G E+V++LL + RC + + + +K Q C E
Sbjct: 166 VNKQDKQKRTALHLASANGNSEVVKLLL--DRRCQLNVLDNKKRTALIKAVQ--CQE--- 218
Query: 273 SMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDC 332
E A MLL+ G + N GNT LH A+
Sbjct: 219 ------------------------DECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLM 254
Query: 333 AIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASK 392
A LL +GA+ +++ +HG TPL L + + +++K LI A ++ + +G T LA
Sbjct: 255 AKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVC 314
Query: 393 IGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHH 432
G +I++LL + + G A + + + HH
Sbjct: 315 CG----SASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHH 350
Score = 48.9 bits (115), Expect = 2e-05
Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 9/194 (4%)
Query: 171 LVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQL 230
+V T ++ D + T H A NS+V++LL + LN ++N+ T L A Q
Sbjct: 158 IVMLRDTDVNKQDKQKRTALHLASANGNSEVVKLL-LDRRCQLNVLDNKKRTALIKAVQC 216
Query: 231 GKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGAS 289
+ E +LL NI G +H A+ K A+ ++ + + I SK+ ++G +
Sbjct: 217 QEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALL-LYGADIESKN-KHGLT 274
Query: 290 PL----HWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADA 345
PL H K ++ + L+K+ N+N+ G TAL +AV +LL + +
Sbjct: 275 PLLLGVHEQKQ-QVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSS 333
Query: 346 RGEHGNTPLHLAMS 359
+ G T A+S
Sbjct: 334 QDLSGQTAREYAVS 347
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,220,722
Number of Sequences: 37866
Number of extensions: 1438271
Number of successful extensions: 7069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 335
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 3164
Number of HSP's gapped (non-prelim): 1957
length of query: 806
length of database: 18,247,518
effective HSP length: 110
effective length of query: 696
effective length of database: 14,082,258
effective search space: 9801251568
effective search space used: 9801251568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.