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Search of human proteins with 13399328
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13399328 G-protein-coupled receptor induced protein [Homo
sapiens]
(372 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13399328 G-protein-coupled receptor induced protein [Homo sap... 757 0.0
gi|11056054 tribbles homolog 2 [Homo sapiens] 382 e-106
gi|31542265 tribbles 3 [Homo sapiens] 284 8e-77
gi|31543198 serine/threonine kinase 40 [Homo sapiens] 121 9e-28
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 120 2e-27
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 119 3e-27
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 118 1e-26
gi|156105707 SNF related kinase [Homo sapiens] 116 3e-26
gi|156105705 SNF related kinase [Homo sapiens] 116 3e-26
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 116 4e-26
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 116 4e-26
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 116 4e-26
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 116 4e-26
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 116 4e-26
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 116 4e-26
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 116 4e-26
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 116 4e-26
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 115 5e-26
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 115 6e-26
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 115 6e-26
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 114 1e-25
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 114 1e-25
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 114 1e-25
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 114 1e-25
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 113 2e-25
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 113 2e-25
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 113 2e-25
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 113 2e-25
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 113 2e-25
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 113 2e-25
>gi|13399328 G-protein-coupled receptor induced protein [Homo
sapiens]
Length = 372
Score = 757 bits (1954), Expect = 0.0
Identities = 372/372 (100%), Positives = 372/372 (100%)
Query: 1 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL 60
MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL
Sbjct: 1 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL 60
Query: 61 SPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCK 120
SPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCK
Sbjct: 61 SPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCK 120
Query: 121 VFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREE 180
VFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREE
Sbjct: 121 VFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREE 180
Query: 181 EAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALS 240
EAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALS
Sbjct: 181 EAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALS 240
Query: 241 DKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQ 300
DKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQ
Sbjct: 241 DKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQ 300
Query: 301 FCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPE 360
FCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPE
Sbjct: 301 FCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPE 360
Query: 361 YQEDSDISSFFC 372
YQEDSDISSFFC
Sbjct: 361 YQEDSDISSFFC 372
>gi|11056054 tribbles homolog 2 [Homo sapiens]
Length = 343
Score = 382 bits (982), Expect = e-106
Identities = 198/322 (61%), Positives = 239/322 (74%), Gaps = 16/322 (4%)
Query: 54 SSPPDYLSPP-GSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIH 112
+ P SP GSP P+ P + S I YLLL E +HV RA+ +H
Sbjct: 33 AEPSQSFSPNLGSPSPPETPNLSHCV----------SCIGKYLLLEPLEGDHVFRAVHLH 82
Query: 113 TGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVR 172
+G EL CKVF I YQ+ + P L +HSNI I E+ILGETKAYVFFE+ +GDMHS+VR
Sbjct: 83 SGEELVCKVFDISCYQESLAPCFCLSAHSNINQITEIILGETKAYVFFERSYGDMHSFVR 142
Query: 173 SRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIM 232
+ K+LREEEAARLF QI SAVAHCH +VL DLKLRKF+F EERT+++LESLED +I+
Sbjct: 143 TCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYIL 202
Query: 233 KGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSAL 292
+G+DD+LSDKHGCPAYVSPEILNT+G+YSGKAADVWSLGVMLYT+LVGRYPFHD +PS+L
Sbjct: 203 RGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSL 262
Query: 293 FSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFE---SVLEPGYIDS 349
FSKIRRGQF IPE +SPKA+CLIRS+LRREPSERLT+ EIL HPWF SV Y
Sbjct: 263 FSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAK 322
Query: 350 EIGTSDQIVPEYQEDSDISSFF 371
E+ SDQ+VP+ + ++ FF
Sbjct: 323 EV--SDQLVPDVNMEENLDPFF 342
>gi|31542265 tribbles 3 [Homo sapiens]
Length = 358
Score = 284 bits (727), Expect = 8e-77
Identities = 149/297 (50%), Positives = 191/297 (64%), Gaps = 5/297 (1%)
Query: 66 PCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPI 124
PC P PP AP +A SR+ Y+LL E +AL TG E CKV+P+
Sbjct: 45 PCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPV 101
Query: 125 KHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAAR 184
+ + PY +LP H ++ EV+ G Y FF + GDMHS VRSR R+ E EAA
Sbjct: 102 QEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAV 161
Query: 185 LFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHG 244
LF+Q+ +A+AHCHQ +VL DLKL +FVF+ ER +L LE+LED+ ++ G DD+L DKH
Sbjct: 162 LFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHA 221
Query: 245 CPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIP 304
CPAYV PEIL++ +YSGKAADVWSLGV L+T+L G YPF DS+P LF KIRRG + +P
Sbjct: 222 CPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALP 281
Query: 305 EHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GYIDSEIGTSDQIVPE 360
+S ARCL+R LLRREP+ERLTA ILLHPW P S + + Q+VP+
Sbjct: 282 AGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPD 338
>gi|31543198 serine/threonine kinase 40 [Homo sapiens]
Length = 435
Score = 121 bits (304), Expect = 9e-28
Identities = 71/182 (39%), Positives = 102/182 (56%), Gaps = 6/182 (3%)
Query: 156 AYVFFEK--DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 213
A+ F +K D ++ YV KRL E E +F +V V HQ IV DLKL V
Sbjct: 146 AHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVL 205
Query: 214 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 273
+ H++ E D L D+ G PAY+SP++L+ Y GK +D+W+LGV+
Sbjct: 206 NKRTHRITITNFCLGKHLVS-EGDLLKDQRGSPAYISPDVLSGR-PYRGKPSDMWALGVV 263
Query: 274 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE--HISPKARCLIRSLLRREPSERLTAPE 331
L+T+L G++PF+DS P LF KI+ ++ IPE +S CLIR LL +P +RL A +
Sbjct: 264 LFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAAD 323
Query: 332 IL 333
+L
Sbjct: 324 VL 325
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 120 bits (302), Expect = 2e-27
Identities = 76/238 (31%), Positives = 121/238 (50%), Gaps = 6/238 (2%)
Query: 135 IQLPSHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAV 193
++L H +I + +VI T ++ E G++ Y+ R+ E EA RLF+QI+SAV
Sbjct: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127
Query: 194 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 253
+CH+ +V DLK + ++ L + M + + L G P Y +PE+
Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEV 184
Query: 254 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 313
++ Y+G D+WS GV+LY LL G PF D LF KIR G F IPE+++
Sbjct: 185 ISGR-LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243
Query: 314 LIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFF 371
L+ +L+ +P +R T +I H WF+ L P Y+ E + D V + + ++ F
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDL-PSYLFPEDPSYDANVIDDEAVKEVCEKF 300
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 119 bits (299), Expect = 3e-27
Identities = 67/205 (32%), Positives = 108/205 (52%), Gaps = 5/205 (2%)
Query: 135 IQLPSHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAV 193
++L H ++ + +V + Y+ E G++ Y+ + RL +EA + F+QIVSA+
Sbjct: 85 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSAL 144
Query: 194 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 253
CH +I DLK + +E+ +R+ + G D L G P Y PE+
Sbjct: 145 DFCHSYSICHRDLKPENLLL--DEKNNIRIADFGMASLQVG-DSLLETSCGSPHYACPEV 201
Query: 254 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 313
+ Y G+ AD+WS GV+L+ LLVG PF D + L K++RG F +P I P +
Sbjct: 202 IKGE-KYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS 260
Query: 314 LIRSLLRREPSERLTAPEILLHPWF 338
L+R ++ EP +RL+ +I HPW+
Sbjct: 261 LLRGMIEVEPEKRLSLEQIQKHPWY 285
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 118 bits (295), Expect = 1e-26
Identities = 70/200 (35%), Positives = 111/200 (55%), Gaps = 5/200 (2%)
Query: 140 HSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 198
H +I + V+ K ++ E G++ Y+ S+ RL EEE +F+QIVSAVA+ H
Sbjct: 66 HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 125
Query: 199 SAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDA-LSDKHGCPAYVSPEILNTT 257
DLK +F +E +L+L KG D L G AY +PE++
Sbjct: 126 QGYAHRDLKPENLLF--DEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGK 183
Query: 258 GTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRS 317
+Y G ADVWS+G++LY L+ G PF D + AL+ KI RG++ +P+ +SP + L++
Sbjct: 184 -SYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQ 242
Query: 318 LLRREPSERLTAPEILLHPW 337
+L+ +P +R++ +L HPW
Sbjct: 243 MLQVDPKKRISMKNLLNHPW 262
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 116 bits (291), Expect = 3e-26
Identities = 71/209 (33%), Positives = 111/209 (53%), Gaps = 5/209 (2%)
Query: 135 IQLPSHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKR-LREEEAARLFKQIVSA 192
++L H NI + EVI +TK Y+ E D GDM Y+ + L E+ A + F QIV A
Sbjct: 67 MKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHA 126
Query: 193 VAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPE 252
+++CH+ +V DLK VF ++ + G+ L+ G AY +PE
Sbjct: 127 ISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK--LTTSCGSLAYSAPE 184
Query: 253 ILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKAR 312
IL Y A D+WSLGV+L+ L+ G+ PF +++ S + I ++ +P H+S + +
Sbjct: 185 IL-LGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECK 243
Query: 313 CLIRSLLRREPSERLTAPEILLHPWFESV 341
LI +L+R+P R + EI HPW + V
Sbjct: 244 DLITRMLQRDPKRRASLEEIENHPWLQGV 272
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 116 bits (291), Expect = 3e-26
Identities = 71/209 (33%), Positives = 111/209 (53%), Gaps = 5/209 (2%)
Query: 135 IQLPSHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKR-LREEEAARLFKQIVSA 192
++L H NI + EVI +TK Y+ E D GDM Y+ + L E+ A + F QIV A
Sbjct: 67 MKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHA 126
Query: 193 VAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPE 252
+++CH+ +V DLK VF ++ + G+ L+ G AY +PE
Sbjct: 127 ISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKK--LTTSCGSLAYSAPE 184
Query: 253 ILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKAR 312
IL Y A D+WSLGV+L+ L+ G+ PF +++ S + I ++ +P H+S + +
Sbjct: 185 IL-LGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECK 243
Query: 313 CLIRSLLRREPSERLTAPEILLHPWFESV 341
LI +L+R+P R + EI HPW + V
Sbjct: 244 DLITRMLQRDPKRRASLEEIENHPWLQGV 272
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 116 bits (290), Expect = 4e-26
Identities = 76/246 (30%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + TG E K+ K + ++ L HSNI + + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 217 -ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++G+ A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L P++R+TA E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 332 ILLHPW 337
L HPW
Sbjct: 266 ALKHPW 271
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 116 bits (290), Expect = 4e-26
Identities = 76/246 (30%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + TG E K+ K + ++ L HSNI + + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 217 -ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++G+ A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L P++R+TA E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 332 ILLHPW 337
L HPW
Sbjct: 266 ALKHPW 271
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 116 bits (290), Expect = 4e-26
Identities = 76/246 (30%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + TG E K+ K + ++ L HSNI + + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 217 -ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++G+ A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L P++R+TA E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 332 ILLHPW 337
L HPW
Sbjct: 266 ALKHPW 271
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 116 bits (290), Expect = 4e-26
Identities = 76/246 (30%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + TG E K+ K + ++ L HSNI + + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 217 -ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++G+ A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L P++R+TA E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 332 ILLHPW 337
L HPW
Sbjct: 266 ALKHPW 271
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 116 bits (290), Expect = 4e-26
Identities = 76/246 (30%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + TG E K+ K + ++ L HSNI + + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 217 -ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++G+ A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L P++R+TA E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 332 ILLHPW 337
L HPW
Sbjct: 266 ALKHPW 271
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 116 bits (290), Expect = 4e-26
Identities = 76/246 (30%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + TG E K+ K + ++ L HSNI + + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 217 -ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++G+ A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L P++R+TA E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 332 ILLHPW 337
L HPW
Sbjct: 266 ALKHPW 271
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 116 bits (290), Expect = 4e-26
Identities = 76/246 (30%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + TG E K+ K + ++ L HSNI + + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 217 -ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++G+ A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L P++R+TA E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 332 ILLHPW 337
L HPW
Sbjct: 266 ALKHPW 271
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 116 bits (290), Expect = 4e-26
Identities = 76/246 (30%), Positives = 124/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + TG E K+ K + ++ L HSNI + + I E Y
Sbjct: 28 VRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHY 87
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 88 LVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 147
Query: 217 -ERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++G+ A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 148 CKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILY 205
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L P++R+TA E
Sbjct: 206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHE 265
Query: 332 ILLHPW 337
L HPW
Sbjct: 266 ALKHPW 271
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 115 bits (289), Expect = 5e-26
Identities = 75/227 (33%), Positives = 118/227 (51%), Gaps = 13/227 (5%)
Query: 130 KIRPYIQ---LPSHSNITGIVEVILGETKAYVFFEKDF---GDMHSYVRSRKRLREEEAA 183
KIR IQ L H +I + +VI T + +F ++ G++ Y+ RL E+E+
Sbjct: 71 KIRREIQNLKLFRHPHIIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGRLDEKESR 128
Query: 184 RLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKH 243
RLF+QI+S V +CH+ +V DLK + ++ L + M + + L
Sbjct: 129 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSC 185
Query: 244 GCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCI 303
G P Y +PE+++ Y+G D+WS GV+LY LL G PF D LF KI G F
Sbjct: 186 GSPNYAAPEVISGR-LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYT 244
Query: 304 PEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSE 350
P++++P L++ +L+ +P +R T +I H WF+ L P Y+ E
Sbjct: 245 PQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDL-PKYLFPE 290
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 115 bits (288), Expect = 6e-26
Identities = 76/246 (30%), Positives = 123/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + G+E K+ K + ++ L H NI + + I E Y
Sbjct: 27 VRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHY 86
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 87 LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 146
Query: 217 ER-TQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++GE A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 147 LKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY--GKPVDLWACGVILY 204
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L PS+R+TA E
Sbjct: 205 ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAE 264
Query: 332 ILLHPW 337
L HPW
Sbjct: 265 ALKHPW 270
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 115 bits (288), Expect = 6e-26
Identities = 76/246 (30%), Positives = 123/246 (50%), Gaps = 15/246 (6%)
Query: 105 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQ-------LPSHSNITGIVEVILGETKAY 157
V R + + G+E K+ K + ++ L H NI + + I E Y
Sbjct: 27 VRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHY 86
Query: 158 VFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 216
+ F+ G++ + +R+ E +A+ +QI+ AV HCHQ +V DLK + +++
Sbjct: 87 LIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASK 146
Query: 217 ER-TQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++L ++GE A G P Y+SPE+L GK D+W+ GV+LY
Sbjct: 147 LKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY--GKPVDLWACGVILY 204
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIP----EHISPKARCLIRSLLRREPSERLTAPE 331
LLVG PF D D L+ +I+ G + P + ++P+A+ LI +L PS+R+TA E
Sbjct: 205 ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAE 264
Query: 332 ILLHPW 337
L HPW
Sbjct: 265 ALKHPW 270
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 114 bits (286), Expect = 1e-25
Identities = 82/266 (30%), Positives = 131/266 (49%), Gaps = 20/266 (7%)
Query: 105 VSRALCIHTGRELRCKVFP--------IKHYQDKIRPYIQLPSHSNITGIVEVILGETKA 156
V A I TGRE+ K+ ++ ++R +++ +H NI + EVI E
Sbjct: 70 VKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVR-IMKILNHPNIVKLFEVIETEKTL 128
Query: 157 YVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 215
Y+ E G++ Y+ + R++E+EA F+QIVSAV +CHQ IV DLK +
Sbjct: 129 YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDA 188
Query: 216 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++ + + G+ D G P Y +PE+ Y G DVWSLGV+LY
Sbjct: 189 DMNIKIADFGFSNEFTVGGKLDTFC---GSPPYAAPELFQGK-KYDGPEVDVWSLGVILY 244
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 335
TL+ G PF + L ++ RG++ IP ++S L++ L P +R T +I+
Sbjct: 245 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKD 304
Query: 336 PWF-----ESVLEPGYIDSEIGTSDQ 356
W E L+P +++ E+ SDQ
Sbjct: 305 RWINAGHEEDELKP-FVEPELDISDQ 329
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 114 bits (286), Expect = 1e-25
Identities = 82/266 (30%), Positives = 131/266 (49%), Gaps = 20/266 (7%)
Query: 105 VSRALCIHTGRELRCKVFP--------IKHYQDKIRPYIQLPSHSNITGIVEVILGETKA 156
V A I TGRE+ K+ ++ ++R +++ +H NI + EVI E
Sbjct: 70 VKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVR-IMKILNHPNIVKLFEVIETEKTL 128
Query: 157 YVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 215
Y+ E G++ Y+ + R++E+EA F+QIVSAV +CHQ IV DLK +
Sbjct: 129 YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDA 188
Query: 216 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++ + + G+ D G P Y +PE+ Y G DVWSLGV+LY
Sbjct: 189 DMNIKIADFGFSNEFTVGGKLDTFC---GSPPYAAPELFQGK-KYDGPEVDVWSLGVILY 244
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 335
TL+ G PF + L ++ RG++ IP ++S L++ L P +R T +I+
Sbjct: 245 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKD 304
Query: 336 PWF-----ESVLEPGYIDSEIGTSDQ 356
W E L+P +++ E+ SDQ
Sbjct: 305 RWINAGHEEDELKP-FVEPELDISDQ 329
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 114 bits (286), Expect = 1e-25
Identities = 82/266 (30%), Positives = 131/266 (49%), Gaps = 20/266 (7%)
Query: 105 VSRALCIHTGRELRCKVFP--------IKHYQDKIRPYIQLPSHSNITGIVEVILGETKA 156
V A I TGRE+ K+ ++ ++R +++ +H NI + EVI E
Sbjct: 70 VKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVR-IMKILNHPNIVKLFEVIETEKTL 128
Query: 157 YVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 215
Y+ E G++ Y+ + R++E+EA F+QIVSAV +CHQ IV DLK +
Sbjct: 129 YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDA 188
Query: 216 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++ + + G+ D G P Y +PE+ Y G DVWSLGV+LY
Sbjct: 189 DMNIKIADFGFSNEFTVGGKLDTFC---GSPPYAAPELFQGK-KYDGPEVDVWSLGVILY 244
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 335
TL+ G PF + L ++ RG++ IP ++S L++ L P +R T +I+
Sbjct: 245 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKD 304
Query: 336 PWF-----ESVLEPGYIDSEIGTSDQ 356
W E L+P +++ E+ SDQ
Sbjct: 305 RWINAGHEEDELKP-FVEPELDISDQ 329
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 114 bits (286), Expect = 1e-25
Identities = 82/266 (30%), Positives = 131/266 (49%), Gaps = 20/266 (7%)
Query: 105 VSRALCIHTGRELRCKVFP--------IKHYQDKIRPYIQLPSHSNITGIVEVILGETKA 156
V A I TGRE+ K+ ++ ++R +++ +H NI + EVI E
Sbjct: 70 VKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVR-IMKILNHPNIVKLFEVIETEKTL 128
Query: 157 YVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 215
Y+ E G++ Y+ + R++E+EA F+QIVSAV +CHQ IV DLK +
Sbjct: 129 YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDA 188
Query: 216 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 275
+ ++ + + G+ D G P Y +PE+ Y G DVWSLGV+LY
Sbjct: 189 DMNIKIADFGFSNEFTVGGKLDTFC---GSPPYAAPELFQGK-KYDGPEVDVWSLGVILY 244
Query: 276 TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 335
TL+ G PF + L ++ RG++ IP ++S L++ L P +R T +I+
Sbjct: 245 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKD 304
Query: 336 PWF-----ESVLEPGYIDSEIGTSDQ 356
W E L+P +++ E+ SDQ
Sbjct: 305 RWINAGHEEDELKP-FVEPELDISDQ 329
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 113 bits (283), Expect = 2e-25
Identities = 84/292 (28%), Positives = 141/292 (48%), Gaps = 21/292 (7%)
Query: 84 SAPGPSRIADYLLLPLAEREHVSR---ALCIHTGRELRCKVFP--------IKHYQDKIR 132
SA I +Y LL + + ++ A I TG+E+ K+ ++ ++R
Sbjct: 43 SADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR 102
Query: 133 PYIQLPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 191
+++ +H NI + EVI E Y+ E G++ Y+ + R++E+EA F+QIVS
Sbjct: 103 -IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 161
Query: 192 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 251
AV +CHQ IV DLK + + ++ + + D G P Y +P
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFC---GSPPYAAP 218
Query: 252 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 311
E+ Y G DVWSLGV+LYTL+ G PF + L ++ RG++ IP ++S
Sbjct: 219 ELFQGK-KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277
Query: 312 RCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQE 363
L++ L PS+R T +I+ W + G+ D E+ + +P+Y++
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRW----MNVGHEDDELKPYVEPLPDYKD 325
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 113 bits (283), Expect = 2e-25
Identities = 84/292 (28%), Positives = 141/292 (48%), Gaps = 21/292 (7%)
Query: 84 SAPGPSRIADYLLLPLAEREHVSR---ALCIHTGRELRCKVFP--------IKHYQDKIR 132
SA I +Y LL + + ++ A I TG+E+ K+ ++ ++R
Sbjct: 43 SADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR 102
Query: 133 PYIQLPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 191
+++ +H NI + EVI E Y+ E G++ Y+ + R++E+EA F+QIVS
Sbjct: 103 -IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 161
Query: 192 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 251
AV +CHQ IV DLK + + ++ + + D G P Y +P
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFC---GSPPYAAP 218
Query: 252 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 311
E+ Y G DVWSLGV+LYTL+ G PF + L ++ RG++ IP ++S
Sbjct: 219 ELFQGK-KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277
Query: 312 RCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQE 363
L++ L PS+R T +I+ W + G+ D E+ + +P+Y++
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRW----MNVGHEDDELKPYVEPLPDYKD 325
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 113 bits (283), Expect = 2e-25
Identities = 84/292 (28%), Positives = 141/292 (48%), Gaps = 21/292 (7%)
Query: 84 SAPGPSRIADYLLLPLAEREHVSR---ALCIHTGRELRCKVFP--------IKHYQDKIR 132
SA I +Y LL + + ++ A I TG+E+ K+ ++ ++R
Sbjct: 43 SADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR 102
Query: 133 PYIQLPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 191
+++ +H NI + EVI E Y+ E G++ Y+ + R++E+EA F+QIVS
Sbjct: 103 -IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 161
Query: 192 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 251
AV +CHQ IV DLK + + ++ + + D G P Y +P
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFC---GSPPYAAP 218
Query: 252 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 311
E+ Y G DVWSLGV+LYTL+ G PF + L ++ RG++ IP ++S
Sbjct: 219 ELFQGK-KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277
Query: 312 RCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQE 363
L++ L PS+R T +I+ W + G+ D E+ + +P+Y++
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRW----MNVGHEDDELKPYVEPLPDYKD 325
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 113 bits (283), Expect = 2e-25
Identities = 84/292 (28%), Positives = 141/292 (48%), Gaps = 21/292 (7%)
Query: 84 SAPGPSRIADYLLLPLAEREHVSR---ALCIHTGRELRCKVFP--------IKHYQDKIR 132
SA I +Y LL + + ++ A I TG+E+ K+ ++ ++R
Sbjct: 43 SADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR 102
Query: 133 PYIQLPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 191
+++ +H NI + EVI E Y+ E G++ Y+ + R++E+EA F+QIVS
Sbjct: 103 -IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 161
Query: 192 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 251
AV +CHQ IV DLK + + ++ + + D G P Y +P
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFC---GSPPYAAP 218
Query: 252 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 311
E+ Y G DVWSLGV+LYTL+ G PF + L ++ RG++ IP ++S
Sbjct: 219 ELFQGK-KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277
Query: 312 RCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQE 363
L++ L PS+R T +I+ W + G+ D E+ + +P+Y++
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRW----MNVGHEDDELKPYVEPLPDYKD 325
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 113 bits (283), Expect = 2e-25
Identities = 84/292 (28%), Positives = 141/292 (48%), Gaps = 21/292 (7%)
Query: 84 SAPGPSRIADYLLLPLAEREHVSR---ALCIHTGRELRCKVFP--------IKHYQDKIR 132
SA I +Y LL + + ++ A I TG+E+ K+ ++ ++R
Sbjct: 10 SADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVR 69
Query: 133 PYIQLPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVS 191
+++ +H NI + EVI E Y+ E G++ Y+ + R++E+EA F+QIVS
Sbjct: 70 -IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 128
Query: 192 AVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 251
AV +CHQ IV DLK + + ++ + + D G P Y +P
Sbjct: 129 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFC---GSPPYAAP 185
Query: 252 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKA 311
E+ Y G DVWSLGV+LYTL+ G PF + L ++ RG++ IP ++S
Sbjct: 186 ELFQGK-KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 244
Query: 312 RCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQE 363
L++ L PS+R T +I+ W + G+ D E+ + +P+Y++
Sbjct: 245 ENLLKKFLILNPSKRGTLEQIMKDRW----MNVGHEDDELKPYVEPLPDYKD 292
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 113 bits (283), Expect = 2e-25
Identities = 65/205 (31%), Positives = 105/205 (51%), Gaps = 5/205 (2%)
Query: 135 IQLPSHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAV 193
++L H ++ + +V + Y+ E G++ Y+ + RL +EA + F+QI+SA+
Sbjct: 70 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 129
Query: 194 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 253
CH +I DLK + +E+ +R+ + G D L G P Y PE+
Sbjct: 130 DFCHSHSICHRDLKPENLLL--DEKNNIRIADFGMASLQVG-DSLLETSCGSPHYACPEV 186
Query: 254 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 313
+ Y G+ ADVWS GV+L+ LLVG PF D + L K++RG F +P I P +
Sbjct: 187 IRGE-KYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS 245
Query: 314 LIRSLLRREPSERLTAPEILLHPWF 338
L+R ++ + + RLT I H W+
Sbjct: 246 LLRGMIEVDAARRLTLEHIQKHIWY 270
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,865,912
Number of Sequences: 37866
Number of extensions: 952308
Number of successful extensions: 13454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 436
Number of HSP's successfully gapped in prelim test: 602
Number of HSP's that attempted gapping in prelim test: 9997
Number of HSP's gapped (non-prelim): 3032
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.