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Search of human proteins with 133925811
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|133925811 transportin 1 isoform 1 [Homo sapiens]
(898 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|133925811 transportin 1 isoform 1 [Homo sapiens] 1822 0.0
gi|23510381 transportin 1 isoform 2 [Homo sapiens] 1804 0.0
gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso... 1566 0.0
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof... 1566 0.0
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso... 1558 0.0
gi|19923142 karyopherin beta 1 [Homo sapiens] 118 2e-26
gi|24797086 importin 5 [Homo sapiens] 77 9e-14
gi|45331213 RAN binding protein 6 [Homo sapiens] 69 1e-11
gi|62460637 importin 4 [Homo sapiens] 67 1e-10
gi|29029559 CSE1 chromosome segregation 1-like protein [Homo sap... 53 1e-06
gi|198041777 Ran binding protein 11 isoform 1 [Homo sapiens] 46 1e-04
gi|39725950 Ran binding protein 11 isoform 2 [Homo sapiens] 46 1e-04
gi|21361659 importin 9 [Homo sapiens] 41 0.006
gi|122937211 KIAA0368 protein [Homo sapiens] 41 0.006
gi|4504487 histidine rich calcium binding protein precursor [Hom... 39 0.022
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 39 0.028
gi|156071452 nardilysin isoform b [Homo sapiens] 39 0.028
gi|21361794 TIP120 protein [Homo sapiens] 38 0.037
gi|6912478 karyopherin alpha 6 [Homo sapiens] 38 0.048
gi|55956788 nucleolin [Homo sapiens] 37 0.063
gi|115529449 upstream binding transcription factor, RNA polymera... 37 0.063
gi|115529451 upstream binding transcription factor, RNA polymera... 37 0.063
gi|7657671 upstream binding transcription factor, RNA polymerase... 37 0.063
gi|39812229 karyopherin alpha 5 [Homo sapiens] 37 0.082
gi|4504901 karyopherin alpha 4 [Homo sapiens] 37 0.11
gi|4507943 exportin 1 [Homo sapiens] 36 0.14
gi|169202818 PREDICTED: similar to hCG1991922 [Homo sapiens] 36 0.14
gi|156071450 nardilysin isoform a [Homo sapiens] 36 0.14
gi|21361399 alpha isoform of regulatory subunit A, protein phosp... 36 0.18
gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens] 35 0.24
>gi|133925811 transportin 1 isoform 1 [Homo sapiens]
Length = 898
Score = 1822 bits (4719), Expect = 0.0
Identities = 898/898 (100%), Positives = 898/898 (100%)
Query: 1 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF 60
MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF
Sbjct: 1 MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIF 60
Query: 61 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI 120
VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI
Sbjct: 61 VLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGI 120
Query: 121 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL 180
LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL
Sbjct: 121 LITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL 180
Query: 181 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR 240
NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR
Sbjct: 181 NIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVR 240
Query: 241 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV 300
KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV
Sbjct: 241 KNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDV 300
Query: 301 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED 360
LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED
Sbjct: 301 LVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDED 360
Query: 361 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV 420
GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV
Sbjct: 361 GIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWV 420
Query: 421 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ 480
VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ
Sbjct: 421 VKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQ 480
Query: 481 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK 540
PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK
Sbjct: 481 PPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSK 540
Query: 541 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS 600
YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS
Sbjct: 541 YQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSS 600
Query: 601 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA 660
VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA
Sbjct: 601 VATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLA 660
Query: 661 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI 720
EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI
Sbjct: 661 EGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPI 720
Query: 721 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA 780
LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA
Sbjct: 721 LGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTA 780
Query: 781 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF 840
ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF
Sbjct: 781 ITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDF 840
Query: 841 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898
IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
Sbjct: 841 IFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898
>gi|23510381 transportin 1 isoform 2 [Homo sapiens]
Length = 890
Score = 1804 bits (4673), Expect = 0.0
Identities = 890/890 (100%), Positives = 890/890 (100%)
Query: 9 MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSE 68
MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSE
Sbjct: 1 MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSE 60
Query: 69 DEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK 128
DEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK
Sbjct: 61 DEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK 120
Query: 129 GELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFL 188
GELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFL
Sbjct: 121 GELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFL 180
Query: 189 QFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALV 248
QFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALV
Sbjct: 181 QFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALV 240
Query: 249 MLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKL 308
MLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKL
Sbjct: 241 MLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKL 300
Query: 309 IPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDD 368
IPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDD
Sbjct: 301 IPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDD 360
Query: 369 DDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILV 428
DDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILV
Sbjct: 361 DDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILV 420
Query: 429 LGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKP 488
LGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKP
Sbjct: 421 LGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKP 480
Query: 489 LMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLI 548
LMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLI
Sbjct: 481 LMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLI 540
Query: 549 LYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSG 608
LYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSG
Sbjct: 541 LYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSG 600
Query: 609 FLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIE 668
FLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIE
Sbjct: 601 FLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIE 660
Query: 669 QLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPE 728
QLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPE
Sbjct: 661 QLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPE 720
Query: 729 FISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGY 788
FISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGY
Sbjct: 721 FISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGY 780
Query: 789 VCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVA 848
VCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVA
Sbjct: 781 VCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVA 840
Query: 849 SWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898
SWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
Sbjct: 841 SWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 890
>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b)
isoform 3 [Homo sapiens]
Length = 887
Score = 1566 bits (4055), Expect = 0.0
Identities = 758/887 (85%), Positives = 830/887 (93%), Gaps = 1/887 (0%)
Query: 12 EWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEP 71
+W+PDEQGLQQ+LQLLK+SQSP+T QR VQ KL+QLNQ+PDFNNYLIFVLT+LKSEDEP
Sbjct: 2 DWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEP 61
Query: 72 TRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGEL 131
TRSLSGLILKNNVKAH+Q+FP V DFIK ECLNNIGD+S LIRAT+GILITTIASKGEL
Sbjct: 62 TRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGEL 121
Query: 132 QNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFF 191
Q WP+LLP+LC+LL+SEDYNTCEGAFGALQKICEDS+E+LDSD L+RPLNIMIPKFLQFF
Sbjct: 122 QMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFF 181
Query: 192 KHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLL 251
KH SPKIRSHA+ACVNQFI+ R QALM +ID+FIE+LFALA D++PEVRKNVCRALVMLL
Sbjct: 182 KHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLL 241
Query: 252 EVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPV 311
EVR+DRL+PHMH+I++YMLQRTQD DENVALEACEFWLTLAEQPICK+VL HL +LIP+
Sbjct: 242 EVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPI 301
Query: 312 LVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDE 371
LVNGMKYS+IDIILLKGDVEEDE +PDSEQDI+PRFH+SRTV H+ + + +D +D+
Sbjct: 302 LVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDD 361
Query: 372 IDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGA 431
DDDD +SDWNLRKCSAAALDVLANV+R+ELLPH+LPLLK LLFH EWVVKESGILVLGA
Sbjct: 362 -DDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
Query: 432 IAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMT 491
IAEGCMQGM+PYLPELIPHLIQCLSDKKALVRSI CWTLSRYAHWVVSQPPD +LKPLMT
Sbjct: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480
Query: 492 ELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYD 551
ELLKRILD NKRVQEAACSAFATLEEEACTELVPYL+YILDTLVFAF KYQHKNLLILYD
Sbjct: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540
Query: 552 AIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLP 611
AIGTLADSVGHHLN+PEYIQ LMPPLIQKWN LKDEDKDLFPLLECLSSVATALQSGFLP
Sbjct: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600
Query: 612 YCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLV 671
YCEPVYQRCV LVQKTLAQAM+ P+QYEAPDKDFMIVALDLLSGLAEGLGG++EQLV
Sbjct: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660
Query: 672 ARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFIS 731
ARSNI+TL++QCMQD MPEVRQSSFALLGDLTKACF HVKPCIA+FMPILGTNLNPEFIS
Sbjct: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720
Query: 732 VCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCP 791
VCNNATWAIGEI +QMG EMQPY+ MVL+ LVEIINRPNTPKTLLENTAITIGRLGYVCP
Sbjct: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780
Query: 792 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWI 851
QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGIC MI VNP GV+QDFIFFCDAVASW+
Sbjct: 781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV 840
Query: 852 NPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898
+PKDDLRDMF KILHGFK+QVG++NW++FS+QFP LKERLAAFYGV
Sbjct: 841 SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887
>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform
2 [Homo sapiens]
Length = 887
Score = 1566 bits (4055), Expect = 0.0
Identities = 758/887 (85%), Positives = 830/887 (93%), Gaps = 1/887 (0%)
Query: 12 EWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEP 71
+W+PDEQGLQQ+LQLLK+SQSP+T QR VQ KL+QLNQ+PDFNNYLIFVLT+LKSEDEP
Sbjct: 2 DWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEP 61
Query: 72 TRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGEL 131
TRSLSGLILKNNVKAH+Q+FP V DFIK ECLNNIGD+S LIRAT+GILITTIASKGEL
Sbjct: 62 TRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGEL 121
Query: 132 QNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFF 191
Q WP+LLP+LC+LL+SEDYNTCEGAFGALQKICEDS+E+LDSD L+RPLNIMIPKFLQFF
Sbjct: 122 QMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFF 181
Query: 192 KHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLL 251
KH SPKIRSHA+ACVNQFI+ R QALM +ID+FIE+LFALA D++PEVRKNVCRALVMLL
Sbjct: 182 KHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLL 241
Query: 252 EVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPV 311
EVR+DRL+PHMH+I++YMLQRTQD DENVALEACEFWLTLAEQPICK+VL HL +LIP+
Sbjct: 242 EVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPI 301
Query: 312 LVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDE 371
LVNGMKYS+IDIILLKGDVEEDE +PDSEQDI+PRFH+SRTV H+ + + +D +D+
Sbjct: 302 LVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDD 361
Query: 372 IDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGA 431
DDDD +SDWNLRKCSAAALDVLANV+R+ELLPH+LPLLK LLFH EWVVKESGILVLGA
Sbjct: 362 -DDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
Query: 432 IAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMT 491
IAEGCMQGM+PYLPELIPHLIQCLSDKKALVRSI CWTLSRYAHWVVSQPPD +LKPLMT
Sbjct: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480
Query: 492 ELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYD 551
ELLKRILD NKRVQEAACSAFATLEEEACTELVPYL+YILDTLVFAF KYQHKNLLILYD
Sbjct: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540
Query: 552 AIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLP 611
AIGTLADSVGHHLN+PEYIQ LMPPLIQKWN LKDEDKDLFPLLECLSSVATALQSGFLP
Sbjct: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600
Query: 612 YCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLV 671
YCEPVYQRCV LVQKTLAQAM+ P+QYEAPDKDFMIVALDLLSGLAEGLGG++EQLV
Sbjct: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660
Query: 672 ARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFIS 731
ARSNI+TL++QCMQD MPEVRQSSFALLGDLTKACF HVKPCIA+FMPILGTNLNPEFIS
Sbjct: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720
Query: 732 VCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCP 791
VCNNATWAIGEI +QMG EMQPY+ MVL+ LVEIINRPNTPKTLLENTAITIGRLGYVCP
Sbjct: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTAITIGRLGYVCP 780
Query: 792 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWI 851
QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGIC MI VNP GV+QDFIFFCDAVASW+
Sbjct: 781 QEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFIFFCDAVASWV 840
Query: 852 NPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898
+PKDDLRDMF KILHGFK+QVG++NW++FS+QFP LKERLAAFYGV
Sbjct: 841 SPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 887
>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b)
isoform 1 [Homo sapiens]
Length = 897
Score = 1558 bits (4034), Expect = 0.0
Identities = 758/897 (84%), Positives = 830/897 (92%), Gaps = 11/897 (1%)
Query: 12 EWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEP 71
+W+PDEQGLQQ+LQLLK+SQSP+T QR VQ KL+QLNQ+PDFNNYLIFVLT+LKSEDEP
Sbjct: 2 DWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEP 61
Query: 72 TRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGEL 131
TRSLSGLILKNNVKAH+Q+FP V DFIK ECLNNIGD+S LIRAT+GILITTIASKGEL
Sbjct: 62 TRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGEL 121
Query: 132 QNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFF 191
Q WP+LLP+LC+LL+SEDYNTCEGAFGALQKICEDS+E+LDSD L+RPLNIMIPKFLQFF
Sbjct: 122 QMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFF 181
Query: 192 KHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLL 251
KH SPKIRSHA+ACVNQFI+ R QALM +ID+FIE+LFALA D++PEVRKNVCRALVMLL
Sbjct: 182 KHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLL 241
Query: 252 EVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPV 311
EVR+DRL+PHMH+I++YMLQRTQD DENVALEACEFWLTLAEQPICK+VL HL +LIP+
Sbjct: 242 EVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPI 301
Query: 312 LVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDE 371
LVNGMKYS+IDIILLKGDVEEDE +PDSEQDI+PRFH+SRTV H+ + + +D +D+
Sbjct: 302 LVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDD 361
Query: 372 IDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGA 431
DDDD +SDWNLRKCSAAALDVLANV+R+ELLPH+LPLLK LLFH EWVVKESGILVLGA
Sbjct: 362 -DDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA 420
Query: 432 IAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMT 491
IAEGCMQGM+PYLPELIPHLIQCLSDKKALVRSI CWTLSRYAHWVVSQPPD +LKPLMT
Sbjct: 421 IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT 480
Query: 492 ELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYD 551
ELLKRILD NKRVQEAACSAFATLEEEACTELVPYL+YILDTLVFAF KYQHKNLLILYD
Sbjct: 481 ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD 540
Query: 552 AIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLP 611
AIGTLADSVGHHLN+PEYIQ LMPPLIQKWN LKDEDKDLFPLLECLSSVATALQSGFLP
Sbjct: 541 AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP 600
Query: 612 YCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLV 671
YCEPVYQRCV LVQKTLAQAM+ P+QYEAPDKDFMIVALDLLSGLAEGLGG++EQLV
Sbjct: 601 YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV 660
Query: 672 ARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFIS 731
ARSNI+TL++QCMQD MPEVRQSSFALLGDLTKACF HVKPCIA+FMPILGTNLNPEFIS
Sbjct: 661 ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS 720
Query: 732 VCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENT----------AI 781
VCNNATWAIGEI +QMG EMQPY+ MVL+ LVEIINRPNTPKTLLENT AI
Sbjct: 721 VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAI 780
Query: 782 TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFI 841
TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGIC MI VNP GV+QDFI
Sbjct: 781 TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFI 840
Query: 842 FFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898
FFCDAVASW++PKDDLRDMF KILHGFK+QVG++NW++FS+QFP LKERLAAFYGV
Sbjct: 841 FFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 897
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 118 bits (296), Expect = 2e-26
Identities = 177/799 (22%), Positives = 326/799 (40%), Gaps = 119/799 (14%)
Query: 22 QILQLLKESQSPDTTIQRTVQQKLEQ--LNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLI 79
+++ +L+++ SPD Q+ LE+ + P F L VL + R +GL
Sbjct: 2 ELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLAN-PGNSQVARVAAGLQ 60
Query: 80 LKNN-------VKAHFQN----FPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK 128
+KN+ +KA +Q +K+ L +G + + + ++
Sbjct: 61 IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE 120
Query: 129 GELQNWPDLLPKLCSLLDSEDY--NTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPK 186
+ WP+L+P+L + + + + + E A+ IC+D +D + L N ++
Sbjct: 121 IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD----IDPEQLQDKSNEILTA 176
Query: 187 FLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRA 246
+Q + P N ++ T AL+ ++ N D+E E
Sbjct: 177 IIQGMRKEEPS---------NNVKLAATNALLNSLEFTKANF-----DKESE-------- 214
Query: 247 LVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHL- 305
H I++ + + TQ D V + A + + + + + ++
Sbjct: 215 ---------------RHFIMQVVCEATQCPDTRVRVAALQNLVKIMS--LYYQYMETYMG 257
Query: 306 PKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDI-----------RPRFHRSRTVA 354
P L + + MK SDID + L+G +E + D E D+ RP H S+ A
Sbjct: 258 PALFAITIEAMK-SDIDEVALQG-IEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYA 315
Query: 355 Q---QHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLK 411
+ Q+ + + DE DDDD DWN K + L +LA D+++PH+LP +K
Sbjct: 316 KGALQYLVPILTQTLTKQDENDDDD---DWNPCKAAGVCLMLLATCCEDDIVPHVLPFIK 372
Query: 412 ELLFHHEWVVKESGILVLGAIAEGCMQGMI-PYLPELIPHLIQCLSDKKALVRSITCWTL 470
E + + +W +++ ++ G I EG + P + + +P LI+ + D +VR WT+
Sbjct: 373 EHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTV 432
Query: 471 SRYAHWVVSQP-PDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAY 529
R + D YL PL+ L++ L + RV C AF++L EA E
Sbjct: 433 GRICELLPEAAINDVYLAPLLQCLIEG-LSAEPRVASNVCWAFSSL-AEAAYEAADVADD 490
Query: 530 ILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLN-KPEYIQMLMPPLIQKWNMLKDED 588
+ + S LI+ + T GH N + + LM ++K+
Sbjct: 491 QEEPATYCLSSSFE---LIVQKLLETTDRPDGHQNNLRSSAYESLM-------EIVKNSA 540
Query: 589 KDLFPLLECLSSVATALQSGFLPYCEPVYQRC----VNLVQKTLAQAMLNNAQPDQYE-- 642
KD +P ++ + V L + N +Q L + N + Q++
Sbjct: 541 KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA 600
Query: 643 APDKDFMIVALDLLSGLAEGLGGNIEQ-LVARSNILTLM----YQCMQDKMP-------- 689
D ++ +L + G GG E L+A S ++ ++ + M+ P
Sbjct: 601 LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN 660
Query: 690 ----EVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFI--SVCNNATWAIGEI 743
+V ++ L+GDL +A ++ P + M +L NL E + SV G+I
Sbjct: 661 YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI 720
Query: 744 SIQMGIEMQPYIPMVLHQL 762
++ +G E + Y+ +VL+ L
Sbjct: 721 ALAIGGEFKKYLEVVLNTL 739
>gi|24797086 importin 5 [Homo sapiens]
Length = 1115
Score = 76.6 bits (187), Expect = 9e-14
Identities = 149/673 (22%), Positives = 271/673 (40%), Gaps = 115/673 (17%)
Query: 21 QQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSED--EPTRSLSGL 78
QQ LL SPD +++ ++ E + + + F+L +++ E R ++ +
Sbjct: 27 QQFYLLLGNLLSPDNVVRKQAEETYENIPG----QSKITFLLQAIRNTTAAEEARQMAAV 82
Query: 79 ILKNNVKAHFQN----FPNGVTDFIKSECLNNIG-DSSPLIRATVGILITTIA----SKG 129
+L+ + + F P+ V IKSE L I ++ +R V + +A +
Sbjct: 83 LLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLIDED 142
Query: 130 ELQNWPDLLPKLCSLLDSEDYNTCEGA---FGALQKICEDSAEILDSDVLDRPLNIMIPK 186
WP+ L L + S++ E A F I + + DV+ R M+ +
Sbjct: 143 GNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHY-LDVIKR----MLVQ 197
Query: 187 FLQFFKHSSPKIRSHAVACVNQFIISRTQ--ALMLHIDSFIENLFALAGDEEPEVRKNVC 244
+Q +H P IR+ + FI++ AL H + D + +V
Sbjct: 198 CMQDQEH--PSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVL 255
Query: 245 RALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALE--ACEFWLTLAEQPICK---- 298
++LV + + L PH+ ++ L+ D N A E +TL+E
Sbjct: 256 KSLVEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKH 315
Query: 299 -DVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQH 357
+++ + +P+++ ++V D+EEDE ++
Sbjct: 316 TNIVAQTIPQMLAMMV---------------DLEEDEDWANA------------------ 342
Query: 358 DEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKE----L 413
DE++DDD S+ +ALD +A +L +LP++KE +
Sbjct: 343 ------------DELEDDDFDSN---AVAGESALDRMACGLGGKL---VLPMIKEHIMQM 384
Query: 414 LFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 473
L + +W + +G++ L AI EGC Q M L E++ ++ L D VR C + +
Sbjct: 385 LQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 444
Query: 474 AHWVVSQPPDTYLKPLMTELLKRILD-SNKRVQEAACSAFATLEEEACTE--LVPYL--- 527
A + + ++ LL+ + D N+RVQ A +A E+ C + L+PYL
Sbjct: 445 ATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTED-CPKSLLIPYLDNL 503
Query: 528 -AYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKP--EYIQMLMPPLIQKWNML 584
++ +V + K ++ + + T SV + Y + MP L K +
Sbjct: 504 VKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSL--KHIVE 561
Query: 585 KDEDKDLFPL----LECLSSVATAL-QSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPD 639
K+L L +EC+S + A+ + F+ V Q L+ KT Q N+ + D
Sbjct: 562 NAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQ----LLLKT--QTDFNDMEDD 615
Query: 640 QYEAPDKDFMIVA 652
P +MI A
Sbjct: 616 D---PQISYMISA 625
>gi|45331213 RAN binding protein 6 [Homo sapiens]
Length = 1105
Score = 69.3 bits (168), Expect = 1e-11
Identities = 137/679 (20%), Positives = 269/679 (39%), Gaps = 127/679 (18%)
Query: 21 QQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLIL 80
Q+ QLLK +P ++R ++ E + +L+ + ++ E R ++ +L
Sbjct: 17 QEFYQLLKNLINPSCMVRRQAEEIYENIPGLCK-TTFLLDAVRNRRAGYE-VRQMAAALL 74
Query: 81 KNNVKAHFQ----NFPNGVTDFIKSECLNNIG-DSSPLIRATV----GILITTIASKGEL 131
+ + + F+ N P V +K E + + ++ +R + +L + +
Sbjct: 75 RRLLSSGFEEVYPNLPADVQRDVKIELILAVKLETHASMRKKLCDIFAVLARNLIDEDGT 134
Query: 132 QNWPDLLPKLCSLLDSEDYNTCEGAFGALQKI--CEDSAEILDSDVLDRPLNIMIPKFLQ 189
+WP+ L L + S++ E A + E D D++ R ++ + +Q
Sbjct: 135 NHWPEGLKFLIDSIYSKNVVLWEVALHVFWHFPGIFGTQERHDLDIIKR----LLDQCIQ 190
Query: 190 FFKHSSPKIRSHAVACVNQFIISRTQALMLHID--SFIENLFALAGDEEPEVRKNVCRAL 247
+H P IR+ + F+++ + L D + + D + +V +L
Sbjct: 191 DQEH--PAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDSVLESL 248
Query: 248 VMLLEVRMDRLLPHMHNIVEYMLQ-----RTQDQDENVALEACEFWLTLAEQ--PICK-- 298
V + + L P++ + ++ L+ R + +ALE +TL+E P+ K
Sbjct: 249 VEIADTVPKYLGPYLEDTLQLSLKLCGDSRLSNLQRQLALEVI---VTLSETATPMLKKH 305
Query: 299 -DVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQH 357
+++ + +P ++ ++V+ Q
Sbjct: 306 TNIIAQAVPHILAMMVD----------------------------------------LQD 325
Query: 358 DEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKE----L 413
DED + ++ ++D+ D + ++ +ALD LA ++ +LP+ KE +
Sbjct: 326 DEDWVNADEMEEDDFDSNAVAAE--------SALDRLACGLGGKV---VLPMTKEHIMQM 374
Query: 414 LFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 473
L +W + +G++ L AI EGC Q M L E + ++ L D VR+ C TL +
Sbjct: 375 LQSPDWKYRHAGLMALSAIGEGCHQQMESILDETVNSVLLFLQDPHPRVRAAACTTLGQM 434
Query: 474 AHWVVSQPPDTYLKPLMTELLKRILD-SNKRVQEAACSAFATLEEEACTELVPYLAYILD 532
A + + ++ LL+ + + N+RVQ A SA E+ L L +D
Sbjct: 435 ATDFAPNFQKKFHETVIAALLRTMENQGNQRVQSHAASALIIFIEDCPKSL---LVLYVD 491
Query: 533 TLVFAFSKYQHKNLLI----------------LYDAIGTLADSVGHHLNKPEYIQMLMPP 576
++V K H L+I L I ++AD++ Y + MP
Sbjct: 492 SMV----KNLHSVLVIKLQELIRNGTKLALEQLVTTIASVADTIEEKF--VPYYDIFMPS 545
Query: 577 LIQKWNMLKDEDKDLF--PLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTL-AQAML 633
L + ++ L +EC+S + A+ E Q N++Q L Q+ L
Sbjct: 546 LKHIVELAVQKELKLLRGKTIECISHIGLAVGK------EKFMQDASNVMQLLLKTQSDL 599
Query: 634 NNAQPDQYEAPDKDFMIVA 652
NN + D P +M+ A
Sbjct: 600 NNMEDDD---PQTSYMVSA 615
>gi|62460637 importin 4 [Homo sapiens]
Length = 1081
Score = 66.6 bits (161), Expect = 1e-10
Identities = 98/438 (22%), Positives = 185/438 (42%), Gaps = 46/438 (10%)
Query: 353 VAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLA-NVYRDELLPHILPLLK 411
VA + ++ ED D +E + + + + + +D+LA ++ ++L P ++P+L+
Sbjct: 299 VAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLE 358
Query: 412 ELLFHHEWVVKESGILVLGAIAEGCMQGMIP-YLPELIPHLIQCLSDKKALVRSITCWTL 470
E L +++G+LVL +++G + LP L+ + + L D +VR+ + L
Sbjct: 359 EALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFAL 418
Query: 471 SRYAHWVVSQPP----DTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 526
+++ + QP + PL+ LK + + AC A E ++ PY
Sbjct: 419 GQFSENL--QPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPY 476
Query: 527 LAYILDTLVFAF---SKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNM 583
L +++ ++ S + K L + A+G +A + L Y +M L +
Sbjct: 477 LPELMECMLQLLRNPSSPRAKELAV--SALGAIATAAQASL--LPYFPAIMEHLRE---F 529
Query: 584 LKDEDKDLFPL----LECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPD 639
L +DL P+ LE L +A A+ P E Q + L D
Sbjct: 530 LLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC--------------D 575
Query: 640 QYEAPDKDFMIVAL-DLLSGL-AEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFA 697
Q + PD +L LSGL EGL ++EQ+ + ++ L + + +P+ SS
Sbjct: 576 QVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQI---TTLMLLSLRSTEGIVPQYDGSSSF 632
Query: 698 LLGDLTKACFQHVKPCIADF-----MPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQ 752
LL D + + D I G ++ F + A+GEIS+ +
Sbjct: 633 LLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFL 692
Query: 753 PYIPMVLHQLVEIINRPN 770
PY+ V ++ +++ P+
Sbjct: 693 PYMESVFEEVFKLLECPH 710
Score = 48.9 bits (115), Expect = 2e-05
Identities = 90/446 (20%), Positives = 179/446 (40%), Gaps = 54/446 (12%)
Query: 387 SAAALDVLANVYRDELL---PHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPY 443
S + + A ++R E L P +L LL+ +E G+L+L + + P+
Sbjct: 97 SLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPH 156
Query: 444 LPELIPHLIQCLSDKKA---LVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDS 500
EL+ L + L + + L S+ TL+ A ++ ++ D L ++ L + +
Sbjct: 157 HRELLRLLNETLGEVGSPGLLFYSLR--TLTTMAPYLSTE--DVPLARMLVPKLIMAMQT 212
Query: 501 NKRVQEA-ACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNL-----LILYDAIG 554
+ EA AC A L+E +E+ Y+ + L F ++ L + + +
Sbjct: 213 LIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLT 272
Query: 555 TLADSVGHHLNKPEYIQMLMPPLIQKW----------NMLKDEDKDL------FPLLECL 598
L L K L+PPL+ L ED+D L+
Sbjct: 273 FLVKVKSKALLK----NRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGET 328
Query: 599 SSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSG 658
L P + C L+ + + L + P Q +A L +L+
Sbjct: 329 PKHFAVQVVDMLALHLPPEKLCPQLMP--MLEEALRSESPYQRKA--------GLLVLAV 378
Query: 659 LAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFM 718
L++G G +I Q + +L ++ + ++D VR ++ LG ++ H+ + M
Sbjct: 379 LSDGAGDHIRQRLLPP-LLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVM 437
Query: 719 PILGTNLNPEFISVCNN---ATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTL 775
P+L L + ++ A +A+ +G ++QPY+P ++ +++++ P++P+
Sbjct: 438 PLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRA- 496
Query: 776 LENTAITIGRLGYVCPQEVAPMLQQF 801
+ + LG + A +L F
Sbjct: 497 ---KELAVSALGAIATAAQASLLPYF 519
>gi|29029559 CSE1 chromosome segregation 1-like protein [Homo
sapiens]
Length = 971
Score = 52.8 bits (125), Expect = 1e-06
Identities = 68/325 (20%), Positives = 134/325 (41%), Gaps = 57/325 (17%)
Query: 17 EQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKL-KSEDEPTRSL 75
+ LQ + + LK++ PD I+R ++ LE + NY + +LT L KS+D +
Sbjct: 5 DANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGN---QNYPLLLLTLLEKSQDNVIKVC 61
Query: 76 SGLILKNNVKAHF---QNFPNGVTDF----IKSECLNNIGDSSPLIRATVGILITTIASK 128
+ + KN +K ++ ++ PN + + IK+ ++ + S I+ + I+ I +
Sbjct: 62 ASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGRE 121
Query: 129 GELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKF- 187
Q WPDLL ++ + S D++ G + + S+ L + +++ F
Sbjct: 122 DFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFA 181
Query: 188 ---LQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFI---ENLFALAGDEEPEVRK 241
FK + +HA + AL + S I + ++L + PE
Sbjct: 182 LPLTNLFKATIELCSTHA---------NDASALRILFSSLILISKLFYSLNFQDLPE--- 229
Query: 242 NVCRALVMLLEVRMDRLLPHMHNI--VEYMLQRTQDQDENVALEACEFWLTLAEQPICKD 299
E M+ + + H + ++ L +T D++E LE L + IC +
Sbjct: 230 --------FFEDNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLE-------LLKSQICDN 274
Query: 300 VLV----------RHLPKLIPVLVN 314
+ R+LP+ + + N
Sbjct: 275 AALYAQKYDEEFQRYLPRFVTAIWN 299
>gi|198041777 Ran binding protein 11 isoform 1 [Homo sapiens]
Length = 1015
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/132 (21%), Positives = 66/132 (50%), Gaps = 6/132 (4%)
Query: 23 ILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKN 82
+LQ+L ++ S DT + + +++L+Q P F + L+ + T + D R L+ L K+
Sbjct: 50 VLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTN-HTLDINVRWLAVLYFKH 108
Query: 83 NVKAHFQNF-PNGVTD----FIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDL 137
+ +++ P+ +++ +++ + N + I + +LI +A + WP+L
Sbjct: 109 GIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPEL 168
Query: 138 LPKLCSLLDSED 149
+P L + +D
Sbjct: 169 IPTLIESVKVQD 180
>gi|39725950 Ran binding protein 11 isoform 2 [Homo sapiens]
Length = 975
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/132 (21%), Positives = 66/132 (50%), Gaps = 6/132 (4%)
Query: 23 ILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKN 82
+LQ+L ++ S DT + + +++L+Q P F + L+ + T + D R L+ L K+
Sbjct: 10 VLQVLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTN-HTLDINVRWLAVLYFKH 68
Query: 83 NVKAHFQNF-PNGVTD----FIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDL 137
+ +++ P+ +++ +++ + N + I + +LI +A + WP+L
Sbjct: 69 GIDRYWRRVAPHALSEEEKTTLRAGLITNFNEPINQIATQIAVLIAKVARLDCPRQWPEL 128
Query: 138 LPKLCSLLDSED 149
+P L + +D
Sbjct: 129 IPTLIESVKVQD 140
>gi|21361659 importin 9 [Homo sapiens]
Length = 1041
Score = 40.8 bits (94), Expect = 0.006
Identities = 47/189 (24%), Positives = 86/189 (45%), Gaps = 19/189 (10%)
Query: 15 PDEQGLQQIL-QLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTR 73
P QGL++ L L SP ++ +++++ L +F +L LT R
Sbjct: 16 PVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHLA-ELTVDPQGALAIR 74
Query: 74 SLSGLILKNNVKAHF----QNF-PNGVTD----FIKSECLNNIGDSSPLIRATVGILITT 124
L+ +ILK V+ H+ + F P T+ I+ N + +S +R++V ++
Sbjct: 75 QLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRESISKVRSSVAYAVSA 134
Query: 125 IASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPL--NI 182
IA + WP L L +L S D N GA++ + E + E+ D+ + PL +
Sbjct: 135 IAHWDWPEAWPQLFNLLMEMLVSGDLN---AVHGAMRVLTEFTREVTDTQM---PLVAPV 188
Query: 183 MIPKFLQFF 191
++P+ + F
Sbjct: 189 ILPEMYKIF 197
>gi|122937211 KIAA0368 protein [Homo sapiens]
Length = 2017
Score = 40.8 bits (94), Expect = 0.006
Identities = 35/145 (24%), Positives = 63/145 (43%), Gaps = 8/145 (5%)
Query: 394 LANVYRDELLPHILPLLKELLFHHE-WVVKESGILVLGAIAEGCMQGMIPYLPELIPHLI 452
L ++ D P ++ L HH W ++ IA + + P+LP+L+P L
Sbjct: 1241 LCSLASDLSQPDLVYKFMNLANHHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLY 1300
Query: 453 QCLSDKKALVRSI--TCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACS 510
+ D +R + W +V D YLK ++ +L+K + + RV+E++C
Sbjct: 1301 RYQFDPNLGIRQAMTSIWNALVTDKSMV----DKYLKEILQDLVKNLTSNMWRVRESSCL 1356
Query: 511 AF-ATLEEEACTELVPYLAYILDTL 534
A L +++ L I +TL
Sbjct: 1357 ALNDLLRGRPLDDIIDKLPEIWETL 1381
Score = 35.8 bits (81), Expect = 0.18
Identities = 26/118 (22%), Positives = 52/118 (44%), Gaps = 5/118 (4%)
Query: 403 LPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCL-----SD 457
L ++ + ++ L W +K G + + +IA+ + PYL ++ L+Q L +
Sbjct: 1697 LQELITITQKALQSQSWKMKAQGAIAMASIAKQTSSLVPPYLGMILTALLQGLAGRTWAG 1756
Query: 458 KKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATL 515
K+ L+++I C + A S P ++ +LK N + + A S A +
Sbjct: 1757 KEELLKAIACVVTACSAELEKSVPNQPSTNEILQAVLKECSKENVKYKIVAISCAADI 1814
>gi|4504487 histidine rich calcium binding protein precursor [Homo
sapiens]
Length = 699
Score = 38.9 bits (89), Expect = 0.022
Identities = 22/49 (44%), Positives = 29/49 (59%), Gaps = 7/49 (14%)
Query: 331 EEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTIS 379
EEDE + D P HR Q H+ED +++DDDDD+ DDDD +S
Sbjct: 222 EEDEDVSDGHHHHGPS-HRH----QGHEED--DDDDDDDDDDDDDDDVS 263
Score = 37.4 bits (85), Expect = 0.063
Identities = 22/65 (33%), Positives = 30/65 (46%), Gaps = 15/65 (23%)
Query: 331 EEDETIPDSEQDIRPRFHRSRTVAQQHDED---------------GIEEEDDDDDEIDDD 375
EE+E ++ + + HR R + DED G EE+DDDDD+ DDD
Sbjct: 197 EEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDD 256
Query: 376 DTISD 380
D D
Sbjct: 257 DDDDD 261
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 38.5 bits (88), Expect = 0.028
Identities = 14/26 (53%), Positives = 21/26 (80%)
Query: 355 QQHDEDGIEEEDDDDDEIDDDDTISD 380
Q+H++DG +E+D+DDD+ DDDD D
Sbjct: 251 QEHEDDGEDEDDEDDDDDDDDDDDDD 276
Score = 32.0 bits (71), Expect = 2.7
Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 8/50 (16%)
Query: 327 KGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDD 376
+G VE E D E + + DED +++DDDDD+ D+DD
Sbjct: 239 EGSVESSEEGEDQEHEDDGE--------DEDDEDDDDDDDDDDDDDDEDD 280
>gi|156071452 nardilysin isoform b [Homo sapiens]
Length = 1151
Score = 38.5 bits (88), Expect = 0.028
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 18/102 (17%)
Query: 329 DVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNL----- 383
D EE+E + + E+D S + DE+G ++ED+ DDE DDD D L
Sbjct: 142 DDEEEEEVEEEEEDDD---EDSGAEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEE 198
Query: 384 ---------RKCSAAALDVLANVYRD-ELLPHILPLLKELLF 415
K SAAAL V + D + LP + L+ ++F
Sbjct: 199 RAEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVF 240
>gi|21361794 TIP120 protein [Homo sapiens]
Length = 1230
Score = 38.1 bits (87), Expect = 0.037
Identities = 80/444 (18%), Positives = 172/444 (38%), Gaps = 63/444 (14%)
Query: 151 NTCEGAFGAL------QKICEDSAEILD--SDVLDRPLNIMIPKFLQFFKHSSPKIRSHA 202
N C+ G L Q+ E LD +D+L R +++ P++ S
Sbjct: 129 NVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPR 188
Query: 203 VACVNQFIISRTQALM-----LHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDR 257
+A + II+ +M + +D L L+ ++ + + + + R
Sbjct: 189 LAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHR 248
Query: 258 LLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMK 317
+ ++ I+ +++ D+ + + + + + C + H+ +I + +K
Sbjct: 249 IGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRR--CPKEVYPHVSTIINIC---LK 303
Query: 318 YSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDT 377
Y D D +EDE D++ G +++ DDE DDD
Sbjct: 304 YLTYDPNYNYDDEDEDENAMDAD-------------------GGDDDDQGSDDEYSDDDD 344
Query: 378 ISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCM 437
+S W +R+ +A LD + + R E+LP + L +E+ +
Sbjct: 345 MS-WKVRRAAAKCLDAVVST-RHEMLPEFYKTVSPALISRFKEREEN-------VKADVF 395
Query: 438 QGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRI 497
+ L + P + L D A+ + T T+ + SQ P+ ++ L K++
Sbjct: 396 HAYLSLLKQTRP-VQSWLCDPDAMEQGETPLTM------LQSQVPN-----IVKALHKQM 443
Query: 498 LDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFS-KYQHKNLLILYDAIGTL 556
+ + + ++ + L L ++ ++ ++F+ + K NL I DA+ L
Sbjct: 444 KEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKI--DALSCL 501
Query: 557 ADSVGHHLNK--PEYIQMLMPPLI 578
+ +H + ++Q L+PP++
Sbjct: 502 YVILCNHSPQVFHPHVQALVPPVV 525
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 37.7 bits (86), Expect = 0.048
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 410 LKELLFHHEWVVKESGILVLGAIAEGC-MQGMIPYLPELIPHLIQCLSDKKALVRSITCW 468
L ELL H+++ V + +G I G +Q + +P L+ LS K +R CW
Sbjct: 299 LVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 358
Query: 469 TLSRYA---HWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVP 525
T+S + D + P++ E+L++ + R ++ A A E +
Sbjct: 359 TISNITAGNRAQIQAVIDANIFPVLIEILQK---AEFRTRKEAAWAITNATSGGTPEQIR 415
Query: 526 YL 527
YL
Sbjct: 416 YL 417
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 37.4 bits (85), Expect = 0.063
Identities = 15/52 (28%), Positives = 31/52 (59%)
Query: 329 DVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISD 380
D E+DE + E +I P ++ A +++ E+++DD+D+ DD++ S+
Sbjct: 156 DEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSE 207
Score = 34.7 bits (78), Expect = 0.41
Identities = 16/33 (48%), Positives = 23/33 (69%), Gaps = 1/33 (3%)
Query: 349 RSRTVAQQHDED-GIEEEDDDDDEIDDDDTISD 380
+++ VA+ DE+ E+EDDDDDE D+DD D
Sbjct: 228 KAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDED 260
Score = 33.9 bits (76), Expect = 0.70
Identities = 13/35 (37%), Positives = 24/35 (68%)
Query: 355 QQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAA 389
++ D+D E+E+DD+DE +D+D I ++ +AA
Sbjct: 147 EEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAA 181
Score = 30.4 bits (67), Expect = 7.7
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 359 EDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLA 395
ED EEEDDD +E ++DD D + + AA+ A
Sbjct: 143 EDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAA 179
>gi|115529449 upstream binding transcription factor, RNA polymerase
I isoform b [Homo sapiens]
Length = 727
Score = 37.4 bits (85), Expect = 0.063
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 331 EEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISD 380
EED+ DS +D S + ++ EDG E E+DD+DE DD+D D
Sbjct: 657 EEDDENGDSSED---GGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 703
Score = 30.8 bits (68), Expect = 5.9
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 345 PRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWN 382
P SRT Q E ++E+D+DDE +D++ D N
Sbjct: 625 PNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDEN 662
>gi|115529451 upstream binding transcription factor, RNA polymerase
I isoform b [Homo sapiens]
Length = 727
Score = 37.4 bits (85), Expect = 0.063
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 331 EEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISD 380
EED+ DS +D S + ++ EDG E E+DD+DE DD+D D
Sbjct: 657 EEDDENGDSSED---GGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 703
Score = 30.8 bits (68), Expect = 5.9
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 345 PRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWN 382
P SRT Q E ++E+D+DDE +D++ D N
Sbjct: 625 PNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDEN 662
>gi|7657671 upstream binding transcription factor, RNA polymerase I
isoform a [Homo sapiens]
Length = 764
Score = 37.4 bits (85), Expect = 0.063
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 331 EEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISD 380
EED+ DS +D S + ++ EDG E E+DD+DE DD+D D
Sbjct: 694 EEDDENGDSSED---GGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 740
Score = 30.8 bits (68), Expect = 5.9
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 345 PRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWN 382
P SRT Q E ++E+D+DDE +D++ D N
Sbjct: 662 PNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDEN 699
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 37.0 bits (84), Expect = 0.082
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 410 LKELLFHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCW 468
L ELL H+++ V + +G I G +Q + +P L+ LS K +R CW
Sbjct: 302 LVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACW 361
Query: 469 TLSRYA---HWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVP 525
T+S + D + P++ E+L++ + R ++ A A E +
Sbjct: 362 TVSNITAGNRAQIQAVIDANIFPVLIEILQK---AEFRTRKEAAWAITNATSGGTPEQIR 418
Query: 526 YL 527
YL
Sbjct: 419 YL 420
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 36.6 bits (83), Expect = 0.11
Identities = 44/193 (22%), Positives = 86/193 (44%), Gaps = 12/193 (6%)
Query: 624 VQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQC 683
VQ T +A++ NA D + + A LLS I+ L+ +S IL ++ C
Sbjct: 68 VQNTSLEAIVQNASSDN-QGIQLSAVQAARKLLSS---DRNPPIDDLI-KSGILPILVHC 122
Query: 684 MQ-DKMPEVRQSSFALLGDLTKACFQHVKPCI-ADFMPILGTNLNPEFISVCNNATWAIG 741
++ D P ++ + L ++ + + + ++ +P+ L+ +VC A WA+G
Sbjct: 123 LERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALG 182
Query: 742 EISIQMGIEMQPYIPM--VLHQLVEIINRPNTPKTLLEN-TAITIGRLGYVCPQEVAPML 798
I I G + + Y+ V+ L+ I+ P+ P T L N T + + + P +
Sbjct: 183 NI-IGDGPQCRDYVISLGVVKPLLSFIS-PSIPITFLRNVTWVMVNLCRHKDPPPPMETI 240
Query: 799 QQFIRPWCTSLRN 811
Q+ + C + +
Sbjct: 241 QEILPALCVLIHH 253
Score = 32.3 bits (72), Expect = 2.0
Identities = 51/225 (22%), Positives = 87/225 (38%), Gaps = 35/225 (15%)
Query: 376 DTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG 435
DT+ W L + A + + V ++PH++PLL H E V+ + + +G I G
Sbjct: 261 DTV--WALSYLTDAGNEQIQMVIDSGIVPHLVPLLS----HQEVKVQTAALRAVGNIVTG 314
Query: 436 C-MQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA---HWVVSQPPDTYLKPLMT 491
Q + + + H L+ K + W LS V D L P++
Sbjct: 315 TDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMII 374
Query: 492 ELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYD 551
LL + + Q+ A A + L + V YL I ++ F NLL + D
Sbjct: 375 HLLDK---GDFGTQKEAAWAISNLTISGRKDQVAYL--IQQNVIPPFC-----NLLTVKD 424
Query: 552 AIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLE 596
A + +Q+++ L M +DE + + L+E
Sbjct: 425 A---------------QVVQVVLDGLSNILKMAEDEAETIGNLIE 454
>gi|4507943 exportin 1 [Homo sapiens]
Length = 1071
Score = 36.2 bits (82), Expect = 0.14
Identities = 28/141 (19%), Positives = 62/141 (43%), Gaps = 20/141 (14%)
Query: 457 DKKALVRSITCWTLSRY-----AHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSA 511
D KA++ S + + +Y AHW +LK ++ +L + + +++ VQ+ AC
Sbjct: 535 DNKAIIASNIMYIVGQYPRFLRAHW-------KFLKTVVNKLFEFMHETHDGVQDMACDT 587
Query: 512 FATLEEEA--------CTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHH 563
F + ++ E++P++ IL+ + Q + + Y+A+G + +
Sbjct: 588 FIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQ 647
Query: 564 LNKPEYIQMLMPPLIQKWNML 584
+ I+ M Q W+ +
Sbjct: 648 TVQEHLIEKYMLLPNQVWDSI 668
>gi|169202818 PREDICTED: similar to hCG1991922 [Homo sapiens]
Length = 488
Score = 36.2 bits (82), Expect = 0.14
Identities = 19/53 (35%), Positives = 27/53 (50%), Gaps = 11/53 (20%)
Query: 331 EEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNL 383
EE+E D E + ++ DE+ +EEDD+D+E D DD S W L
Sbjct: 322 EEEENEEDEEDE-----------EEEKDEEDEDEEDDEDEEEDGDDEQSHWQL 363
>gi|156071450 nardilysin isoform a [Homo sapiens]
Length = 1219
Score = 36.2 bits (82), Expect = 0.14
Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 329 DVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSA 388
D EE+E + + E+D S + DE+G ++ED+ DDE DDD D L +
Sbjct: 142 DDEEEEEVEEEEEDDD---EDSGAEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEE 198
Query: 389 AA 390
A
Sbjct: 199 RA 200
>gi|21361399 alpha isoform of regulatory subunit A, protein
phosphatase 2 [Homo sapiens]
Length = 589
Score = 35.8 bits (81), Expect = 0.18
Identities = 73/376 (19%), Positives = 137/376 (36%), Gaps = 58/376 (15%)
Query: 377 TISDWNLRKCSAAALDVLANVYR-DELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG 435
T+ + +R + +L +++ + +L H +PL+K L +W + L ++
Sbjct: 98 TVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLA-GGDWFTSRTSACGLFSVCYP 156
Query: 436 CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLK 495
+ + EL + SD +VR L +A + + + P+ + L
Sbjct: 157 RVSSAVK--AELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLAS 214
Query: 496 RILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGT 555
DS + + AC A L + E A ++ TL A + ++ D
Sbjct: 215 DEQDSVRLLAVEACVNIAQLLPQEDLE-----ALVMPTLRQAAEDKSWRVRYMVADKFTE 269
Query: 556 LADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEP 615
L +VG + K + + P Q N++KD C + V A +CE
Sbjct: 270 LQKAVGPEITKTDLV-----PAFQ--NLMKD----------CEAEVRAAASHKVKEFCEN 312
Query: 616 VYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLG--GNIEQLVAR 673
+ C ++ + + + + ++ ++ GL+ LG IE L
Sbjct: 313 LSADC----RENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHL--- 365
Query: 674 SNILTLMYQCMQDKMPEVR--------------------QSSFALLGDLTKACFQHVKPC 713
L L ++D+ PEVR QS + +L + V+
Sbjct: 366 ---LPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLA 422
Query: 714 IADFMPILGTNLNPEF 729
I ++MP+L L EF
Sbjct: 423 IIEYMPLLAGQLGVEF 438
>gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens]
Length = 1236
Score = 35.4 bits (80), Expect = 0.24
Identities = 66/278 (23%), Positives = 105/278 (37%), Gaps = 59/278 (21%)
Query: 151 NTCEGAFGALQKIC---EDSA---EILD--SDVLDRPLNIMIPKFLQFFKH------SSP 196
N C G L ED A E LD SD+L R L + + F H SSP
Sbjct: 129 NVCRKITGQLTSAIAQQEDVAVQLEALDILSDMLSR-LGVPLGAFHASLLHCLLPQLSSP 187
Query: 197 K--IRSHAVACVNQFIISRTQALMLHI-DSFIENLFALAGDEEPEVRKNVCRALVML--- 250
+ +R AV + + + L + + D ++ L P + + + L +
Sbjct: 188 RLAVRKRAVGALGHLAAACSTDLFVELADHLLDRLPGPRVPTSPTAIRTLIQCLGSVGRQ 247
Query: 251 ----LEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLP 306
L +DRL+P +VE D+ L+A E +L C + H+P
Sbjct: 248 AGHRLGAHLDRLVP----LVEDFCNLDDDELRESCLQAFEAFLRK-----CPKEMGPHVP 298
Query: 307 KLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEED 366
+ + + +K+ D +EDE Q ED E
Sbjct: 299 NVTSLCLQYIKHDPN----YNYDSDEDEE-------------------QMETEDSEFSEQ 335
Query: 367 DDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLP 404
+ +DE DDD +S W +R+ +A + L + R +LLP
Sbjct: 336 ESEDEYSDDDDMS-WKVRRAAAKCIAALIS-SRPDLLP 371
Score = 32.0 bits (71), Expect = 2.7
Identities = 42/166 (25%), Positives = 70/166 (42%), Gaps = 26/166 (15%)
Query: 391 LDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMI--------- 441
L LA V L H+ L+ ++F + S + A +QG++
Sbjct: 460 LTELAGVLPGSLAEHMPVLVSGIIFS---LADRSSSSTIRMDALAFLQGLLGTEPAEAFH 516
Query: 442 PYLPELIPHLIQCLSD---KKALVRSITCWTLSRYAHWVVSQP----PDTYLKPLMTELL 494
P+LP L+P ++ C++D K A + L R A W + +P P+ Y+ + L
Sbjct: 517 PHLPILLPPVMACVADSFYKIAAEALVVLQELVR-ALWPLHRPRMLDPEPYVGEMSAVTL 575
Query: 495 KRI--LDSNKRVQEAACSAF----ATLEEEACTELVPYLAYILDTL 534
R+ D ++ V+E A S L + +L P L +LD L
Sbjct: 576 ARLRATDLDQEVKERAISCMGHLVGHLGDRLGDDLEPTLLLLLDRL 621
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,181,248
Number of Sequences: 37866
Number of extensions: 1526873
Number of successful extensions: 7994
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 6758
Number of HSP's gapped (non-prelim): 708
length of query: 898
length of database: 18,247,518
effective HSP length: 111
effective length of query: 787
effective length of database: 14,044,392
effective search space: 11052936504
effective search space used: 11052936504
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.