Search of human proteins with 133925809

Search of human proteins with 133925809

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein
[Homo sapiens]
         (890 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein [...  1786   0.0  
gi|156119625 inter-alpha (globulin) inhibitor H1 [Homo sapiens]       948   0.0  
gi|70778918 inter-alpha globulin inhibitor H2 polypeptide [Homo ...   681   0.0  
gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]        627   e-179
gi|153945780 inter-alpha trypsin inhibitor heavy chain precursor...   488   e-137
gi|153945711 inter-alpha trypsin inhibitor heavy chain precursor...   409   e-114
gi|38348336 inter-alpha (globulin) inhibitor H5-like [Homo sapiens]   386   e-107
gi|49355778 inter-alpha trypsin inhibitor heavy chain precursor ...   376   e-104
gi|54112390 calcium channel, voltage-dependent, alpha 2/delta su...    61   5e-09
gi|54112394 calcium channel, voltage-dependent, alpha 2/delta su...    57   8e-08
gi|54112392 calcium channel, voltage-dependent, alpha 2/delta su...    57   8e-08
gi|132566536 voltage-gated calcium channel alpha(2)delta-4 subun...    55   4e-07
gi|118918435 von Willebrand factor A domain containing 3B [Homo ...    54   5e-07
gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo...    52   3e-06
gi|194306644 BCSC-1 isoform 1 [Homo sapiens]                           49   3e-05
gi|38195080 BCSC-1 isoform 1 [Homo sapiens]                            49   3e-05
gi|54112397 calcium channel, voltage-dependent, alpha 2/delta 3 ...    48   4e-05
gi|210147462 von Willebrand factor A domain containing 5B1 [Homo...    47   6e-05
gi|38195082 BCSC-1 isoform 2 [Homo sapiens]                            47   8e-05
gi|218505703 von Willebrand factor A domain containing 3A [Homo ...    45   4e-04
gi|110578649 cache domain containing 1 [Homo sapiens]                  38   0.037
gi|65507253 hypothetical protein LOC55196 [Homo sapiens]               36   0.14 
gi|148886654 polydom [Homo sapiens]                                    34   0.69 
gi|224831239 integrin alpha M isoform 1 precursor [Homo sapiens]       33   0.90 
gi|88501734 integrin alpha M isoform 2 precursor [Homo sapiens]        33   0.90 
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]            33   0.90 
gi|169646281 coiled-coil domain containing 14 [Homo sapiens]           33   1.5  
gi|47157325 protein kinase C, delta [Homo sapiens]                     32   3.4  
gi|31377782 protein kinase C, delta [Homo sapiens]                     32   3.4  
gi|119703749 hydrocephalus inducing isoform a [Homo sapiens]           32   3.4  

>gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein
           [Homo sapiens]
          Length = 890

 Score = 1786 bits (4627), Expect = 0.0
 Identities = 890/890 (100%), Positives = 890/890 (100%)

Query: 1   MAFAWWPCLILALLSSLAASGFPRSPFRLLGKRSLPEGVANGIEVYSTKINSKVTSRFAH 60
           MAFAWWPCLILALLSSLAASGFPRSPFRLLGKRSLPEGVANGIEVYSTKINSKVTSRFAH
Sbjct: 1   MAFAWWPCLILALLSSLAASGFPRSPFRLLGKRSLPEGVANGIEVYSTKINSKVTSRFAH 60

Query: 61  NVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVS 120
           NVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVS
Sbjct: 61  NVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVS 120

Query: 121 QGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEMYLKVQPKQLVK 180
           QGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEMYLKVQPKQLVK
Sbjct: 121 QGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEMYLKVQPKQLVK 180

Query: 181 HFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCT 240
           HFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCT
Sbjct: 181 HFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCT 240

Query: 241 DSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKL 300
           DSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKL
Sbjct: 241 DSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKL 300

Query: 301 EQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTFVKSMEDKGMT 360
           EQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTFVKSMEDKGMT
Sbjct: 301 EQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTFVKSMEDKGMT 360

Query: 361 NINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKF 420
           NINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKF
Sbjct: 361 NINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKF 420

Query: 421 PLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYP 480
           PLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYP
Sbjct: 421 PLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYP 480

Query: 481 ENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEME 540
           ENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEME
Sbjct: 481 ENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEME 540

Query: 541 KALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTS 600
           KALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTS
Sbjct: 541 KALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTS 600

Query: 601 MVVTKPEDNEDERAIADKPGEDAEATPVSPAMSYLTSYQPPQNPYYYVDGDPHFIIQIPE 660
           MVVTKPEDNEDERAIADKPGEDAEATPVSPAMSYLTSYQPPQNPYYYVDGDPHFIIQIPE
Sbjct: 601 MVVTKPEDNEDERAIADKPGEDAEATPVSPAMSYLTSYQPPQNPYYYVDGDPHFIIQIPE 660

Query: 661 KDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGIANAQM 720
           KDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGIANAQM
Sbjct: 661 KDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGIANAQM 720

Query: 721 DFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQ 780
           DFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQ
Sbjct: 721 DFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQ 780

Query: 781 VWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVK 840
           VWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVK
Sbjct: 781 VWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVK 840

Query: 841 NHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF 890
           NHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF
Sbjct: 841 NHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF 890


>gi|156119625 inter-alpha (globulin) inhibitor H1 [Homo sapiens]
          Length = 911

 Score =  948 bits (2450), Expect = 0.0
 Identities = 487/896 (54%), Positives = 638/896 (71%), Gaps = 19/896 (2%)

Query: 11  LALLSSLAASGFPRSPFRLLGKRSLPEGVANGIEVYSTKINSKVTSRFAHNVVTMRAVNR 70
           L +L ++ A G      +   KR   +   +G+ + S K+N KVTSRFAH VVT + VN 
Sbjct: 19  LLILQAMPALGSATGRSKSSEKRQAVDTAVDGVFIRSLKVNCKVTSRFAHYVVTSQVVNT 78

Query: 71  ADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVSQGKTAGLVKA 130
           A+ A+EV+FD+E+PKTAFI++F +T DG  + G++K+K  A KQY KA   G+ AGLV+A
Sbjct: 79  ANEAREVAFDLEIPKTAFISDFAVTADGNAFIGDIKDKVTAWKQYRKAAISGENAGLVRA 138

Query: 131 SGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEMYLKVQPKQLVKHFEIEVDIFE 190
           SGR +E+FT+ + V   SKVTF+LTYEE+LKR+  +YE+ +KV+PKQLV HFEI+VDIFE
Sbjct: 139 SGRTMEQFTIHLTVNPQSKVTFQLTYEEVLKRNHMQYEIVIKVKPKQLVHHFEIDVDIFE 198

Query: 191 PQGISMLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTI 250
           PQGIS LDA+ASF+  +L    + KSFSGKKGHV F+P++ QQ+SCPTC+ SLLNG F +
Sbjct: 199 PQGISKLDAQASFLPKELAAQTIKKSFSGKKGHVLFRPTVSQQQSCPTCSTSLLNGHFKV 258

Query: 251 TYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRI 310
           TYDV+R+   ++ + N +F HFFAPQ L  + KNV FVIDISGSM G+K++QTKEALL+I
Sbjct: 259 TYDVSRDKICDLLVANNHFAHFFAPQNLTNMNKNVVFVIDISGSMRGQKVKQTKEALLKI 318

Query: 311 LEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTFVKSMEDKGMTNINDGLLRGI 370
           L DMQ  DY + +LF   V +WK  LVQA+  NLQ A+ FV+       TN+N GLLRGI
Sbjct: 319 LGDMQPGDYFDLVLFGTRVQSWKGSLVQASEANLQAAQDFVRGFSLDEATNLNGGLLRGI 378

Query: 371 SMLNKAREEHRIPERST--SIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFG 428
            +LN+ +E   +PE S   SI+IMLTDGD   G +   +I +NVRNAI G+FPLYNLGFG
Sbjct: 379 EILNQVQES--LPELSNHASILIMLTDGDPTEGVTDRSQILKNVRNAIRGRFPLYNLGFG 436

Query: 429 NNLNYNFLENMALENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYPENAILDLT 488
           +N+++NFLE M++EN+G A+RIYED DA  QLQGFY +VA PLL  V+++YP++A+L LT
Sbjct: 437 HNVDFNFLEVMSMENNGRAQRIYEDHDATQQLQGFYSQVAKPLLVDVDLQYPQDAVLALT 496

Query: 489 QNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEMEKALQERDY 548
           QN ++ +Y+GSEIVVAGR+ D   +SFKADV+ HG   + + T  VD +EM+K L+ER +
Sbjct: 497 QNHHKQYYEGSEIVVAGRIADNKQSSFKADVQAHGEGQEFSITCLVDEEEMKKLLRERGH 556

Query: 549 IFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTSMVVTKPED 608
           +  N++ERLWAYLTI++LL KR     EE+ NL+++AL +SL Y FVTPLTSM +    D
Sbjct: 557 MLENHVERLWAYLTIQELLAKRMKVDREERANLSSQALQMSLDYGFVTPLTSMSIRGMAD 616

Query: 609 NEDERAIADKPGEDAEATP-VSPAMSYLTSYQPPQNPYYY------------VDGDPHFI 655
            +  +   DKP ED+     + P  +++ S   P   +              VD DPHFI
Sbjct: 617 QDGLKPTIDKPSEDSPPLEMLGPRRTFVLSALQPSPTHSSSNTQRLPDRVTGVDTDPHFI 676

Query: 656 IQIPEKDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGI 715
           I +P+K+D LCFNI+E PG +L L+QD  TG +VNGQ+ G+K  SP  +   TYFG+LGI
Sbjct: 677 IHVPQKEDTLCFNINEEPGVILSLVQDPNTGFSVNGQLIGNKARSP-GQHDGTYFGRLGI 735

Query: 716 ANAQMDFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRK-NMVVSFGDGVTF 774
           AN   DFQ+EVT + ITL        FSW D   + QDG+ + IN+K N+VVS  DG TF
Sbjct: 736 ANPATDFQLEVTPQNITLNPGFGGPVFSWRDQAVLRQDGVVVTINKKRNLVVSVDDGGTF 795

Query: 775 VVVLHQVWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPD 834
            VVLH+VWK   VH+DFLGFYV+DSHRMSA+THGLLGQFF P  F+VSDI PGSDPTKPD
Sbjct: 796 EVVLHRVWKGSSVHQDFLGFYVLDSHRMSARTHGLLGQFFHPIGFEVSDIHPGSDPTKPD 855

Query: 835 ATLVVKNHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF 890
           AT+VV+N +L VTRG QKDY KD   G +V CWF+HNNG GLIDG +TDYIVP++F
Sbjct: 856 ATMVVRNRRLTVTRGLQKDYSKDPWHGAEVSCWFIHNNGAGLIDGAYTDYIVPDIF 911


>gi|70778918 inter-alpha globulin inhibitor H2 polypeptide [Homo
           sapiens]
          Length = 946

 Score =  681 bits (1756), Expect = 0.0
 Identities = 354/881 (40%), Positives = 537/881 (60%), Gaps = 43/881 (4%)

Query: 43  IEVYSTKINSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYP 102
           + +YS K+ S +TSR A  ++  + VN +   + V FDV++PK AFI+NF++T+DG T+ 
Sbjct: 70  VTLYSYKVQSTITSRMATTMIQSKVVNNSPQPQNVVFDVQIPKGAFISNFSMTVDGKTFR 129

Query: 103 GNVKEKEVAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKR 162
            ++KEK V +  Y +A ++GKTAGLV++S   +E F   VNV  G+KV FEL Y+E+  R
Sbjct: 130 SSIKEKTVGRALYAQARAKGKTAGLVRSSALDMENFRTEVNVLPGAKVQFELHYQEVKWR 189

Query: 163 HKGKYEMYLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKG 222
             G YE  + +QP +L KH E++V + EPQG+  L    +F  +         S   +K 
Sbjct: 190 KLGSYEHRIYLQPGRLAKHLEVDVWVIEPQGLRFLHVPDTFEGH--FDGVPVISKGQQKA 247

Query: 223 HVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESP-GNVQIVNGYFVHFFAPQGLPVV 281
           HVSFKP++ QQR CP C ++ ++G+  + YDV RE   G +++ NGYFVHFFAP  L  +
Sbjct: 248 HVSFKPTVAQQRICPNCRETAVDGELVVLYDVKREEKAGELEVFNGYFVHFFAPDNLDPI 307

Query: 282 PKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATP 341
           PKN+ FVID+SGSM G K++QT EA+  IL+D++ ED+ + I F+ ++ TW+  L+ AT 
Sbjct: 308 PKNILFVIDVSGSMWGVKMKQTVEAMKTILDDLRAEDHFSVIDFNQNIRTWRNDLISATK 367

Query: 342 ENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVG 401
             + +A+ +++ ++  G TNIN+ LLR I +LN+A     +   S S++I+++DGD  VG
Sbjct: 368 TQVADAKRYIEKIQPSGGTNINEALLRAIFILNEANNLGLLDPNSVSLIILVSDGDPTVG 427

Query: 402 ESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQ 461
           E +  KIQ+NV+  I     L++LG G +++Y+FL+ ++ ENHG A+RIY + D   QL+
Sbjct: 428 ELKLSKIQKNVKENIQDNISLFSLGMGFDVDYDFLKRLSNENHGIAQRIYGNQDTSSQLK 487

Query: 462 GFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKG 521
            FY +V+ PLL  V+  YP  ++ D+TQN + +++ GSEIVVAG+     ++  ++ +  
Sbjct: 488 KFYNQVSTPLLRNVQFNYPHTSVTDVTQNNFHNYFGGSEIVVAGKFDPAKLDQIESVITA 547

Query: 522 HGATNDLTFTEEVDMKEMEKALQERDYIFGNYIERLWAYLTIEQLLEKRKNAH-GEEKEN 580
             A   L       M +++  L +  +   ++  +LWAYLTI QLL +R  A     K  
Sbjct: 548 TSANTQLVLETLAQMDDLQDFLSKDKHADPDFTRKLWAYLTINQLLAERSLAPTAAAKRR 607

Query: 581 LTARALDLSLKYHFVTPLTSMVVTKPEDNE--DERAIADKPGEDA--------------- 623
           +T   L +SL +H VTPLTS+V+    +NE  DER +AD P +D                
Sbjct: 608 ITRSILQMSLDHHIVTPLTSLVI----ENEAGDERMLADAPPQDPSCCSGALYYGSKVVP 663

Query: 624 EATPV------SPAMSYLT-------SYQPPQNPYYYVDGDPHFIIQIPEKDDALCFNID 670
           ++TP       +P +S L        S  PP      V+ DPHFII +P+    +CFNID
Sbjct: 664 DSTPSWANPSPTPVISMLAQGSQVLESTPPPH--VMRVENDPHFIIYLPKSQKNICFNID 721

Query: 671 EAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGIANAQMDFQVEVTTEK 730
             PG +L L+ D  +G+ VNGQ+ G K+  P++    TYFGKLG      D ++E++TE 
Sbjct: 722 SEPGKILNLVSDPESGIVVNGQLVGAKK--PNNGKLSTYFGKLGFYFQSEDIKIEISTET 779

Query: 731 ITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMV-VSFGDGVTFVVVLHQVWKKHPVHR 789
           ITL + +   + SW DT  VT   + + + ++ +V ++    ++F V+LH+VWKKHPV+ 
Sbjct: 780 ITLSHGSSTFSLSWSDTAQVTNQRVQISVKKEKVVTITLDKEMSFSVLLHRVWKKHPVNV 839

Query: 790 DFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVKNHQLIVTRG 849
           DFLG Y+  +++ S + HGL+GQF Q     + + RPG DP KP+A++ VK  +LI+TRG
Sbjct: 840 DFLGIYIPPTNKFSPKAHGLIGQFMQEPKIHIFNERPGKDPEKPEASMEVKGQKLIITRG 899

Query: 850 SQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF 890
            QKDYR D   GT V CWFVHN+G+G IDG + DY VP L+
Sbjct: 900 LQKDYRTDLVFGTDVTCWFVHNSGKGFIDGHYKDYFVPQLY 940


>gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]
          Length = 930

 Score =  627 bits (1616), Expect = e-179
 Identities = 312/582 (53%), Positives = 430/582 (73%), Gaps = 3/582 (0%)

Query: 41  NGIEVYSTKINSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVT 100
           NGI++YS  ++S+V+SRFAH VVT R VNRA+T +E +F +ELPK AFITNF++ IDG+T
Sbjct: 31  NGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMT 90

Query: 101 YPGNVKEKEVAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELL 160
           YPG +KEK  A+ QY  AV++GK+AGLVKA+GR +E+F VSV+VA  +K+TFEL YEELL
Sbjct: 91  YPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELL 150

Query: 161 KRHKGKYEMYLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGK 220
           KR  G YE+ LKV+P+QLVKH ++++ IFEPQGIS L+ E++F+TN L+  ALT   +  
Sbjct: 151 KRRLGVYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLV-DALTTWQNKT 209

Query: 221 KGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRE-SPGNVQIVNGYFVHFFAPQGLP 279
           K H+ FKP+L QQ+  P   +++L+G+  I YDV+R  S G++QI NGYFVH+FAP+GL 
Sbjct: 210 KAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLT 269

Query: 280 VVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQA 339
            +PKNV FVID SGSM+GRK++QT+EAL++IL+D+   D  N I+FS + + W+  LV A
Sbjct: 270 TMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPA 329

Query: 340 TPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDAN 399
           + EN+ +AR+F   ++  G TNIND +L  + +L+ + +E R+PE S S++I+LTDGD  
Sbjct: 330 SAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPT 389

Query: 400 VGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQ 459
           VGE+ P  IQ NVR A+ G++ L+ LGFG +++Y FLE +AL+N G ARRI+EDSD+ LQ
Sbjct: 390 VGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQ 449

Query: 460 LQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADV 519
           LQ FY+EVANPLLT V  EYP NA+ ++TQN ++  + GSE+VVAG+L D   +   A V
Sbjct: 450 LQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTATV 509

Query: 520 KGHGATNDLTFTEEVDMKEMEKALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKE 579
            G   T ++TF  E  + E E   Q   YIF N++ERLWAYLTI+QLLE+  +A   +++
Sbjct: 510 SGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDADQQ 569

Query: 580 NLTARALDLSLKYHFVTPLTSMVVTKPEDNEDERAIADKPGE 621
            L  +AL+LSL Y FVTPLTSMVVTKP+D E  + +A+KP E
Sbjct: 570 ALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQ-VAEKPME 610



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 53/222 (23%), Positives = 91/222 (40%), Gaps = 29/222 (13%)

Query: 652 PHFIIQIPEKD-DALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYF 710
           P  I+ +P +  + LC +     G V  L+ D   G+ V GQ   +K G          F
Sbjct: 732 PSAILPLPGQSVERLCVDPRHRQGPV-NLLSDPEQGVEVTGQYEREKAG----------F 780

Query: 711 GKLGIANAQMDFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVV-SFG 769
             + +        V  + E + +      S + W +T+     GL M +++  +++ S  
Sbjct: 781 SWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDP 840

Query: 770 DGVTFVVVLHQVWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSD 829
           D VT  ++    W       + L   + D+ R S+   G LGQF+Q       ++  GS 
Sbjct: 841 DKVTIGLLF---WDGRG---EGLRLLLRDTDRFSSHVGGTLGQFYQ-------EVLWGSP 887

Query: 830 PTKPDA--TLVVKNHQLIVTRGSQKDYRKDASIGTKVVCWFV 869
               D   TL V+ +    TR  + DY ++   G ++ CW V
Sbjct: 888 AASDDGRRTLRVQGNDHSATRERRLDY-QEGPPGVEISCWSV 928


>gi|153945780 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 1 [Homo sapiens]
          Length = 956

 Score =  488 bits (1255), Expect = e-137
 Identities = 301/891 (33%), Positives = 462/891 (51%), Gaps = 78/891 (8%)

Query: 50  INSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKE 109
           + S + SR+A   V+ R +NRA   +++ F +++P  AFITNFT+ I    Y G + E+E
Sbjct: 56  VKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITERE 115

Query: 110 VAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEM 169
              K+    V + +     +   +  E F  S  + +  K  F L+YEELL+R  GKYE 
Sbjct: 116 ---KKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEH 172

Query: 170 YLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKK-------- 221
            + V+P+QL     ++V+I E  GI+ L+       +   GS   +  SG          
Sbjct: 173 SISVRPQQLSGRLSVDVNILESAGIASLEV-LPLHNSRQRGSGRGEDDSGPPPSTVINQN 231

Query: 222 ---GHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRE-SPGNVQIVNGYFVHFFAPQG 277
               ++ FKP++ QQ        + + GDF I YDVNRE S G++Q++NGYFVH+FAP+ 
Sbjct: 232 ETFANIIFKPTVVQQARI---AQNGILGDFIIRYDVNREQSIGDIQVLNGYFVHYFAPKD 288

Query: 278 LPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLV 337
           LP +PKNV FV+D S SM G KL QTK+AL  IL D++ +D  + I FS  +  WK+HL+
Sbjct: 289 LPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLI 348

Query: 338 QATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGD 397
             TP+++++ + ++  M   G T+IN  L R I +LNK      I +RS S+++ LTDG 
Sbjct: 349 SVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGK 408

Query: 398 ANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDAD 457
             VGE+   KI  N R A  G+  ++ +G GN++++  LE ++LEN G  RR++E+ DA 
Sbjct: 409 PTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAG 468

Query: 458 LQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKA 517
            QL GFY+E+  PLL+ + ++YP ++++  T+  + ++++GSEI++AG+LVD  ++    
Sbjct: 469 SQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHV 528

Query: 518 DVKGHGATNDLTFTEEVDMKEMEKALQ-----------ERDYIFGNYIERLWAYLTIEQL 566
           +V    +   +    +V ++  +               E D    N+IERLW+YLT ++L
Sbjct: 529 EVTASNSKKFIILKTDVPVRPQKAGKDVTGSPRPGGDGEGD---TNHIERLWSYLTTKEL 585

Query: 567 LEKRKNAHGE-EKENLTARALDLSLKYHFVTPLTSMVVTKPEDNEDERAIADKPGEDAEA 625
           L     +  E EKE L  RA  L++ Y F+TP TSM +  P    D   + +  G  A  
Sbjct: 586 LSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMD--GLEEAHGMSAAM 643

Query: 626 TPVSPAMSYLTSYQPP----QNPYY--------YVDGDPHFIIQIPEKDDALCFNIDEAP 673
            P     S   +   P    + PY          VDGDPHF++  P     +CFNID  P
Sbjct: 644 GPEPVVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQP 703

Query: 674 GTVLRLIQD-AVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGI-ANAQMDFQVEVTTEKI 731
           G +LRL+ D   +G+TVNG++ G        K ++TY   + I  N      +E+T  ++
Sbjct: 704 GDILRLVSDHRDSGVTVNGELIGAPAPPNGHKKQRTYLRTITILINKPERSYLEITPSRV 763

Query: 732 TLWNRAVPSTFSWLDTVTVTQDGLSMMIN-RKNMVVSFGDGVTFVVVLHQVWKKHPVHRD 790
            L +           +V V   GL + ++   N+ V+    + FV+++H   K  P  R 
Sbjct: 764 IL-DGGDRLVLPCNQSVVVGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQRH 822

Query: 791 FLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPT----------------KPD 834
            LGFY+ +S  +S+  HGLLGQF         D R   DP                  P+
Sbjct: 823 HLGFYIANSEGLSSNCHGLLGQFLN------QDARLTEDPAGPSQNLTHPLLLQVGEGPE 876

Query: 835 ATLVVKNHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYI 885
           A L VK HQ+ V    +K Y  +  I     CWF  NN   LIDG + DY+
Sbjct: 877 AVLTVKGHQVPVVWKQRKIYNGEEQID----CWFARNNAAKLIDGEYKDYL 923


>gi|153945711 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 2 [Homo sapiens]
          Length = 742

 Score =  409 bits (1052), Expect = e-114
 Identities = 246/707 (34%), Positives = 374/707 (52%), Gaps = 63/707 (8%)

Query: 223 HVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRE-SPGNVQIVNGYFVHFFAPQGLPVV 281
           ++ FKP++ QQ        + + GDF I YDVNRE S G++Q++NGYFVH+FAP+ LP +
Sbjct: 22  NIIFKPTVVQQARI---AQNGILGDFIIRYDVNREQSIGDIQVLNGYFVHYFAPKDLPPL 78

Query: 282 PKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATP 341
           PKNV FV+D S SM G KL QTK+AL  IL D++ +D  + I FS  +  WK+HL+  TP
Sbjct: 79  PKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTP 138

Query: 342 ENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVG 401
           +++++ + ++  M   G T+IN  L R I +LNK      I +RS S+++ LTDG   VG
Sbjct: 139 DSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVG 198

Query: 402 ESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQ 461
           E+   KI  N R A  G+  ++ +G GN++++  LE ++LEN G  RR++E+ DA  QL 
Sbjct: 199 ETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAGSQLI 258

Query: 462 GFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKG 521
           GFY+E+  PLL+ + ++YP ++++  T+  + ++++GSEI++AG+LVD  ++    +V  
Sbjct: 259 GFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTA 318

Query: 522 HGATNDLTFTEEVDMKEMEKALQ-----------ERDYIFGNYIERLWAYLTIEQLLEKR 570
             +   +    +V ++  +               E D    N+IERLW+YLT ++LL   
Sbjct: 319 SNSKKFIILKTDVPVRPQKAGKDVTGSPRPGGDGEGD---TNHIERLWSYLTTKELLSSW 375

Query: 571 KNAHGE-EKENLTARALDLSLKYHFVTPLTSMVVTKPEDNEDERAIADKPGEDAEATPVS 629
             +  E EKE L  RA  L++ Y F+TP TSM +  P    D   + +  G  A   P  
Sbjct: 376 LQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMD--GLEEAHGMSAAMGPEP 433

Query: 630 PAMSYLTSYQPP----QNPYY--------YVDGDPHFIIQIPEKDDALCFNIDEAPGTVL 677
              S   +   P    + PY          VDGDPHF++  P     +CFNID  PG +L
Sbjct: 434 VVQSVRGAGTQPGPLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQPGDIL 493

Query: 678 RLIQD-AVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGI-ANAQMDFQVEVTTEKITLWN 735
           RL+ D   +G+TVNG++ G        K ++TY   + I  N      +E+T  ++ L +
Sbjct: 494 RLVSDHRDSGVTVNGELIGAPAPPNGHKKQRTYLRTITILINKPERSYLEITPSRVIL-D 552

Query: 736 RAVPSTFSWLDTVTVTQDGLSMMIN-RKNMVVSFGDGVTFVVVLHQVWKKHPVHRDFLGF 794
                      +V V   GL + ++   N+ V+    + FV+++H   K  P  R  LGF
Sbjct: 553 GGDRLVLPCNQSVVVGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQRHHLGF 612

Query: 795 YVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPT----------------KPDATLV 838
           Y+ +S  +S+  HGLLGQF         D R   DP                  P+A L 
Sbjct: 613 YIANSEGLSSNCHGLLGQFLN------QDARLTEDPAGPSQNLTHPLLLQVGEGPEAVLT 666

Query: 839 VKNHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYI 885
           VK HQ+ V    +K Y  +  I     CWF  NN   LIDG + DY+
Sbjct: 667 VKGHQVPVVWKQRKIYNGEEQID----CWFARNNAAKLIDGEYKDYL 709


>gi|38348336 inter-alpha (globulin) inhibitor H5-like [Homo sapiens]
          Length = 1313

 Score =  386 bits (991), Expect = e-107
 Identities = 240/610 (39%), Positives = 340/610 (55%), Gaps = 49/610 (8%)

Query: 35  LPEGVANGIEVYSTKINSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITNFTL 94
           +P   +  + + S  + S V SR+AH +VT    N    A E  FD++LP  AFI+NFT+
Sbjct: 27  VPASSSTKLLMTSYSMRSTVVSRYAHTLVTSVLFNPHAEAHEAIFDLDLPHLAFISNFTM 86

Query: 95  TIDGVTYPGNVKEKEVAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFEL 154
           TI+   Y   VKEK  AKK YE+A  QGKTA  V    R+ EKF +S ++AAG++VTF L
Sbjct: 87  TINNKVYIAEVKEKHQAKKIYEEAHQQGKTAAHVGIRDRESEKFRISTSLAAGTEVTFSL 146

Query: 155 TYEELLKRHKGKYEMYLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALT 214
            YEELL+RH+G+Y++ + ++P QLVK   IEV + E  GIS +      I     G   T
Sbjct: 147 AYEELLQRHQGQYQLVVSLRPGQLVKRLSIEVTVSERTGISYV-----HIPPLRTGRLRT 201

Query: 215 KSFSGKKGHVSFKPSLDQQRS--------CPTCTD------SLLNGDFTITYDVNRES-P 259
            + + +   V   PS   +R         CPT  D      S +  DF + YDV  E   
Sbjct: 202 NAHASE---VDSPPSTRIERGETCVRITYCPTLQDQSSISGSGIMADFLVQYDVVMEDII 258

Query: 260 GNVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDY 319
           G+VQI + YF+H+FAP+GLP + KNV FVID+S SM G K+EQTK A+  IL D+Q  DY
Sbjct: 259 GDVQIYDDYFIHYFAPRGLPPMEKNVVFVIDVSSSMFGTKMEQTKTAMNVILSDLQANDY 318

Query: 320 LNFILFSGDVSTWKE-HLVQATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKARE 378
            N I FS  V+ WK    +QAT +N+  A+ ++  ME  G T++N  LL   S+LN + +
Sbjct: 319 FNIISFSDTVNVWKAGGSIQATIQNVHSAKDYLHCMEADGWTDVNSALLAAASVLNHSNQ 378

Query: 379 EHRIPERSTSI-----VIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNY 433
           E   P R  S+     +I LTDG+   G + P  I  NVR A+G +  L++L FG++ ++
Sbjct: 379 E---PGRGPSVGRIPLIIFLTDGEPTAGVTTPSVILSNVRQALGHRVSLFSLAFGDDADF 435

Query: 434 NFLENMALENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQ 493
             L  ++LEN G ARRIYED+DA LQL+G YEE++ PLL  V + Y    +       + 
Sbjct: 436 TLLRRLSLENRGIARRIYEDTDAALQLKGLYEEISMPLLADVRLNYLGGLVGASPWAVFP 495

Query: 494 HFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEMEKALQERDYIFG-- 551
           +++ GSE+VVAG+ V          +   G  + L           E A       FG  
Sbjct: 496 NYFGGSELVVAGQ-VQPGKQELGIHLAARGPKDQLLVAH-----HSEGATNNSQKAFGCP 549

Query: 552 --------NYIERLWAYLTIEQLLEKRKNAHGEEKEN-LTARALDLSLKYHFVTPLTSMV 602
                   ++I RLWAY+TI +LL+    A      + L A+ L+LSL+Y+FVTPLTS+V
Sbjct: 550 GEPAPNVAHFIRRLWAYVTIGELLDAHFQARDTTTRHLLAAKVLNLSLEYNFVTPLTSLV 609

Query: 603 VTKPEDNEDE 612
           + +P+   +E
Sbjct: 610 MVQPKQASEE 619



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 52/188 (27%), Positives = 90/188 (47%), Gaps = 9/188 (4%)

Query: 648  VDGDPHFIIQIPEKDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRK 707
            VDGDPHF+IQIP  ++ +CF ++  PG +L+LI+D   GL V+G++ G           +
Sbjct: 1080 VDGDPHFVIQIPHSEEKICFTLNGHPGDLLQLIEDPKAGLHVSGKLLGAPPRPGHKDQTR 1139

Query: 708  TYFGKLGI-ANAQMDFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMI-NRKNMV 765
            TYF  + +  +    + + ++   I+L         SW     + +  L + +     + 
Sbjct: 1140 TYFQIITVTTDKPRAYTITISRSSISLRGEGT-LRLSWDQPALLKRPQLELYVAAAARLT 1198

Query: 766  VSFGDGVTFVVVLHQVWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIR 825
            +  G  + F+V+ H+      +    LGFYV +   +S    GL+GQ      F+ +DIR
Sbjct: 1199 LRLGPYLEFLVLRHRYRHPSTLQLPHLGFYVANGSGLSPSARGLIGQ------FQHADIR 1252

Query: 826  PGSDPTKP 833
              + P  P
Sbjct: 1253 LVTGPMGP 1260


>gi|49355778 inter-alpha trypsin inhibitor heavy chain precursor 5
           isoform 3 [Homo sapiens]
          Length = 702

 Score =  376 bits (966), Expect = e-104
 Identities = 210/586 (35%), Positives = 330/586 (56%), Gaps = 34/586 (5%)

Query: 50  INSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKE 109
           + S + SR+A   V+ R +NRA   +++ F +++P  AFITNFT+ I    Y G + E+E
Sbjct: 56  VKSTIISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITERE 115

Query: 110 VAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEM 169
              K+    V + +     +   +  E F  S  + +  K  F L+YEELL+R  GKYE 
Sbjct: 116 ---KKSGDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEH 172

Query: 170 YLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKK-------- 221
            + V+P+QL     ++V+I E  GI+ L+       +   GS   +  SG          
Sbjct: 173 SISVRPQQLSGRLSVDVNILESAGIASLEV-LPLHNSRQRGSGRGEDDSGPPPSTVINQN 231

Query: 222 ---GHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRE-SPGNVQIVNGYFVHFFAPQG 277
               ++ FKP++ QQ        + + GDF I YDVNRE S G++Q++NGYFVH+FAP+ 
Sbjct: 232 ETFANIIFKPTVVQQARI---AQNGILGDFIIRYDVNREQSIGDIQVLNGYFVHYFAPKD 288

Query: 278 LPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLV 337
           LP +PKNV FV+D S SM G KL QTK+AL  IL D++ +D  + I FS  +  WK+HL+
Sbjct: 289 LPPLPKNVVFVLDSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLI 348

Query: 338 QATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGD 397
             TP+++++ + ++  M   G T+IN  L R I +LNK      I +RS S+++ LTDG 
Sbjct: 349 SVTPDSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGK 408

Query: 398 ANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDAD 457
             VGE+   KI  N R A  G+  ++ +G GN++++  LE ++LEN G  RR++E+ DA 
Sbjct: 409 PTVGETHTLKILNNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAG 468

Query: 458 LQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKA 517
            QL GFY+E+  PLL+ + ++YP ++++  T+  + ++++GSEI++AG+LVD  ++    
Sbjct: 469 SQLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHV 528

Query: 518 DVKGHGATNDLTFTEEVDMKEMEKALQ-----------ERDYIFGNYIERLWAYLTIEQL 566
           +V    +   +    +V ++  +               E D    N+IERLW+YLT ++L
Sbjct: 529 EVTASNSKKFIILKTDVPVRPQKAGKDVTGSPRPGGDGEGD---TNHIERLWSYLTTKEL 585

Query: 567 LEKRKNAHGE-EKENLTARALDLSLKYHFVTPLTSMVVTKPEDNED 611
           L     +  E EKE L  RA  L++ Y F+TP TSM +  P    D
Sbjct: 586 LSSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRGPVPRMD 631


>gi|54112390 calcium channel, voltage-dependent, alpha 2/delta
           subunit 1 [Homo sapiens]
          Length = 1091

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 48/195 (24%), Positives = 98/195 (50%), Gaps = 14/195 (7%)

Query: 282 PKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSG---DVSTWKEHLVQ 338
           PK++  ++D+SGS++G  L+  + ++  +LE + ++D++N   F+    DVS + +HLVQ
Sbjct: 251 PKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCF-QHLVQ 309

Query: 339 ATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIML-TDGD 397
           A   N +  +  V ++  KG+T+      +G S   +    + +   + + +IML TDG 
Sbjct: 310 ANVRNKKVLKDAVNNITAKGITDYK----KGFSFAFEQLLNYNVSRANCNKIIMLFTDG- 364

Query: 398 ANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDAD 457
              GE R ++I          +   +++G  +N +   ++ MA EN G+   I       
Sbjct: 365 ---GEERAQEIFNKYNKDKKVRVFTFSVG-QHNYDRGPIQWMACENKGYYYEIPSIGAIR 420

Query: 458 LQLQGFYEEVANPLL 472
           +  Q + + +  P++
Sbjct: 421 INTQEYLDVLGRPMV 435


>gi|54112394 calcium channel, voltage-dependent, alpha 2/delta
           subunit 2 isoform b [Homo sapiens]
          Length = 1143

 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 46/194 (23%), Positives = 85/194 (43%), Gaps = 11/194 (5%)

Query: 282 PKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVS--TWKEHLVQA 339
           PK++  ++D+SGS++G  L+  K ++  +L+ + ++DY+N   F+      +   HLVQA
Sbjct: 289 PKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQA 348

Query: 340 TPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDAN 399
              N +  +  V+ M  KG T    G       L  +            +++M TDG   
Sbjct: 349 NVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR---ANCNKMIMMFTDG--- 402

Query: 400 VGESRPEKIQENVRNAIGGKFPLYNLGFG-NNLNYNFLENMALENHGFARRIYEDSDADL 458
            GE R + + E   N       ++    G +N +   L+ MA  N G+   I       +
Sbjct: 403 -GEDRVQDVFEKY-NWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRI 460

Query: 459 QLQGFYEEVANPLL 472
             Q + + +  P++
Sbjct: 461 NTQEYLDVLGRPMV 474


>gi|54112392 calcium channel, voltage-dependent, alpha 2/delta
           subunit 2 isoform a [Homo sapiens]
          Length = 1145

 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 46/194 (23%), Positives = 85/194 (43%), Gaps = 11/194 (5%)

Query: 282 PKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVS--TWKEHLVQA 339
           PK++  ++D+SGS++G  L+  K ++  +L+ + ++DY+N   F+      +   HLVQA
Sbjct: 289 PKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQA 348

Query: 340 TPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDAN 399
              N +  +  V+ M  KG T    G       L  +            +++M TDG   
Sbjct: 349 NVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR---ANCNKMIMMFTDG--- 402

Query: 400 VGESRPEKIQENVRNAIGGKFPLYNLGFG-NNLNYNFLENMALENHGFARRIYEDSDADL 458
            GE R + + E   N       ++    G +N +   L+ MA  N G+   I       +
Sbjct: 403 -GEDRVQDVFEKY-NWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRI 460

Query: 459 QLQGFYEEVANPLL 472
             Q + + +  P++
Sbjct: 461 NTQEYLDVLGRPMV 474


>gi|132566536 voltage-gated calcium channel alpha(2)delta-4 subunit
           [Homo sapiens]
          Length = 1137

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 44/196 (22%), Positives = 92/196 (46%), Gaps = 11/196 (5%)

Query: 282 PKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDV----STWKEHLV 337
           PK++  ++D+SGSM G ++   K  +  IL+ + E D++N I ++  V      +K  LV
Sbjct: 289 PKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFINIIAYNDYVHYIEPCFKGILV 348

Query: 338 QATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGD 397
           QA  +N +  +  V+ +  KG+  + D  LR    + K  +E +        +++++DG 
Sbjct: 349 QADRDNREHFKLLVEELMVKGV-GVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGA 407

Query: 398 ANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNY-NFLENMALENHGFARRIYEDSDA 456
               E   EK      N    K  ++    G  +++ + ++ +A  N G+  +I   +D 
Sbjct: 408 VEDYEPVFEKY-----NWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADT 462

Query: 457 DLQLQGFYEEVANPLL 472
              +  +   ++ P++
Sbjct: 463 QENVMEYLHVLSRPMV 478


>gi|118918435 von Willebrand factor A domain containing 3B [Homo
           sapiens]
          Length = 1294

 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 39/159 (24%), Positives = 78/159 (49%), Gaps = 21/159 (13%)

Query: 285 VAFVIDISGSMAGRKLEQTKEALLRIL-EDMQEEDYLNFILFSGDVSTWKEHLVQATPEN 343
           +  +ID S SM   KL+  K+ +++ + E ++ +   NF+ F G    W+E L +   +N
Sbjct: 509 IYILIDTSHSMKS-KLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAVAWREQLAEVNEDN 567

Query: 344 LQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGES 403
           L++A+++++ ++    TN        +S L  A       ++ T  + +LTDG     + 
Sbjct: 568 LEQAQSWIRDIKIGSSTNT-------LSALKTA-----FADKETQAIYLLTDGRP---DQ 612

Query: 404 RPEKIQENVRNAIGGKFPLYNLGFGNN--LNYNFLENMA 440
            PE + + V+     + P+Y + F  N  +   FL+ +A
Sbjct: 613 PPETVIDQVKRF--QEIPIYTISFNYNDEIANRFLKEVA 649


>gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo
            sapiens]
          Length = 1724

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 127/620 (20%), Positives = 231/620 (37%), Gaps = 69/620 (11%)

Query: 32   KRSLPEGVANGIEVYSTKINSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITN 91
            K  L +   N + +    I  ++    A  +V     N++    E  +   L   A +  
Sbjct: 610  KAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCG 669

Query: 92   FTLTIDGVTYPGNVKEKEVAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSV-NVAAGSKV 150
            F   I+G    G +KEKE A+++Y +AV+QG  A L+       + FTVSV N+   +KV
Sbjct: 670  FEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAP--DVFTVSVGNLPPKAKV 727

Query: 151  TFELTY--EELLKRHKGKYEMYLKVQPKQLVKHFEIEV-DIFEPQGISMLDAEASFITND 207
              ++TY  E  +    G + M   V P Q  K     + D  E   I  +  + SF    
Sbjct: 728  LIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTM 787

Query: 208  LLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCTDSLLNGD-------FTITYDVNRESPG 260
             +       F     H   +   D +    T   S L+          +  Y        
Sbjct: 788  SIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEK 847

Query: 261  NVQIVNGYFVHFFAPQ---GLP--VVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQ 315
            + +  +   +  F P     LP       V   +D S SM G    Q K+  L  L  + 
Sbjct: 848  HPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIALHALSLVG 907

Query: 316  EEDYLNFILFS---GDVSTWKEHLVQATPENLQEARTFVKSMEDKGMTNINDGLLRGISM 372
            E+  +N I F     ++ ++ +H+      N   A   + +    G T+     LR +S+
Sbjct: 908  EKQKVNIIQFGTGYKELFSYPKHIT----SNTMAAEFIMSATPTMGNTDFWK-TLRYLSL 962

Query: 373  LNKAREEHRIPERSTSIVIMLTDG---DANVGESRPEKIQENVRNAIGGKFPLYNLGFGN 429
            L         P R +  +++++DG   D ++     ++ + + R        L+  G G+
Sbjct: 963  L--------YPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTR--------LFACGIGS 1006

Query: 430  NLNYNFLENMALENHGFARRIYEDSDAD--LQLQGFYEEVANPLLTGVEMEYPE--NAIL 485
              N + L  ++    G        S      Q++     + +P    V +++ +    + 
Sbjct: 1007 TANRHVLRILSQCGAGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVP 1066

Query: 486  DLTQNTYQ--HFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEMEKAL 543
            +  Q   Q    +    ++V G +      +  A ++      +  F   V   E++K  
Sbjct: 1067 EALQAPAQVPSLFLNDRLLVYGFIPHCTQATLCALIQ------EKEFRTMVSTTELQKTT 1120

Query: 544  QERDYIFGNYIERLWAYLTI----EQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLT 599
                   G  I +L A   I    + +L + + +H  +K+ L +  + LS +   +T  T
Sbjct: 1121 -------GTMIHKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFT 1173

Query: 600  SMVVTKPEDNEDERAIADKP 619
            S V  +  D E+E    D P
Sbjct: 1174 SFVAVEKRD-ENESPFPDIP 1192


>gi|194306644 BCSC-1 isoform 1 [Homo sapiens]
          Length = 786

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 86/423 (20%), Positives = 152/423 (35%), Gaps = 60/423 (14%)

Query: 64  TMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVSQGK 123
           T+   N      E  F   + + + + +F   +DG      +++K  A+  YEKA+SQG 
Sbjct: 36  TLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKARTNYEKAISQGH 95

Query: 124 TAGLVKASGRKLEKFTVSV-NVAAGSKVTFELTY-EELLKRHKGKYEMYLK--------- 172
            A L++      + F+ +V N+  GSK    L Y +EL     G     L          
Sbjct: 96  QAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLKYVQELPLEADGALRFVLPAVLNPRYQF 155

Query: 173 ---------------VQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKS- 216
                          V  + L     +   I    GI  + +       + LG   T + 
Sbjct: 156 SGSSKDSCLNVKTPIVPVEDLPYTLSMVATIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQ 215

Query: 217 FSGKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQ 276
            S   GH       D+        + +      +   +    PG++       V F+ P 
Sbjct: 216 VSLAAGH-----KFDRDVELLIYYNEVHTPSVVLEMGMPNMKPGHLMGDPSAMVSFY-PN 269

Query: 277 GLPVVPKNVA----FVIDISGSM---------AGRKLEQTKEALLRILEDMQEEDYLNFI 323
                P N      F++D SGSM         +  +++  KE L+ +L+ +    Y N  
Sbjct: 270 IPEDQPSNTCGEFIFLMDRSGSMQSPMSSQDTSQLRIQAAKETLILLLKSLPIGCYFNIY 329

Query: 324 LFSGDVSTWKEHLVQATPENLQEARTFVKSME-DKGMTNINDGLLRGISMLNKAREEHRI 382
            F           V+ T + ++EA   VK M+ D G T I       ++ L        I
Sbjct: 330 GFGSSYEACFPESVKYTQQTMEEALGRVKLMQADLGGTEI-------LAPLQNIYRGPSI 382

Query: 383 PERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALE 442
           P     + +  TDG+     S  ++++ N +     K   ++ G G   + + ++ +A  
Sbjct: 383 PGHPLQLFV-FTDGEVTDTFSVIKEVRINRQ-----KHRCFSFGIGEGTSTSLIKGIARA 436

Query: 443 NHG 445
           + G
Sbjct: 437 SGG 439


>gi|38195080 BCSC-1 isoform 1 [Homo sapiens]
          Length = 786

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 86/423 (20%), Positives = 152/423 (35%), Gaps = 60/423 (14%)

Query: 64  TMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVSQGK 123
           T+   N      E  F   + + + + +F   +DG      +++K  A+  YEKA+SQG 
Sbjct: 36  TLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKARTNYEKAISQGH 95

Query: 124 TAGLVKASGRKLEKFTVSV-NVAAGSKVTFELTY-EELLKRHKGKYEMYLK--------- 172
            A L++      + F+ +V N+  GSK    L Y +EL     G     L          
Sbjct: 96  QAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLKYVQELPLEADGALRFVLPAVLNPRYQF 155

Query: 173 ---------------VQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKS- 216
                          V  + L     +   I    GI  + +       + LG   T + 
Sbjct: 156 SGSSKDSCLNVKTPIVPVEDLPYTLSMVATIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQ 215

Query: 217 FSGKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQ 276
            S   GH       D+        + +      +   +    PG++       V F+ P 
Sbjct: 216 VSLAAGH-----KFDRDVELLIYYNEVHTPSVVLEMGMPNMKPGHLMGDPSAMVSFY-PN 269

Query: 277 GLPVVPKNVA----FVIDISGSM---------AGRKLEQTKEALLRILEDMQEEDYLNFI 323
                P N      F++D SGSM         +  +++  KE L+ +L+ +    Y N  
Sbjct: 270 IPEDQPSNTCGEFIFLMDRSGSMQSPMSSQDTSQLRIQAAKETLILLLKSLPIGCYFNIY 329

Query: 324 LFSGDVSTWKEHLVQATPENLQEARTFVKSME-DKGMTNINDGLLRGISMLNKAREEHRI 382
            F           V+ T + ++EA   VK M+ D G T I       ++ L        I
Sbjct: 330 GFGSSYEACFPESVKYTQQTMEEALGRVKLMQADLGGTEI-------LAPLQNIYRGPSI 382

Query: 383 PERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALE 442
           P     + +  TDG+     S  ++++ N +     K   ++ G G   + + ++ +A  
Sbjct: 383 PGHPLQLFV-FTDGEVTDTFSVIKEVRINRQ-----KHRCFSFGIGEGTSTSLIKGIARA 436

Query: 443 NHG 445
           + G
Sbjct: 437 SGG 439


>gi|54112397 calcium channel, voltage-dependent, alpha 2/delta 3
           subunit [Homo sapiens]
          Length = 1091

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 44/197 (22%), Positives = 88/197 (44%), Gaps = 17/197 (8%)

Query: 282 PKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDV----STWKEHLV 337
           PK+V  ++D+SGSM G +L   K+ +  IL+ + ++D+ N I ++ ++          LV
Sbjct: 254 PKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLV 313

Query: 338 QATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGD 397
           QA   N +  R  +  +  KG+  ++  L    ++L+      +     +  ++++TDG 
Sbjct: 314 QADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQ-GSICSQAIMLITDGA 372

Query: 398 ANVGESRPEKIQENVRNAIGGKFPLYNLG----FGNNLNYNFLENMALENHGFARRIYED 453
            +  ++   K     R     +   Y +G    F +NL +     MA  N GF  +I   
Sbjct: 373 VDTYDTIFAKYNWPDRKV---RIFTYLIGREAAFADNLKW-----MACANKGFFTQISTL 424

Query: 454 SDADLQLQGFYEEVANP 470
           +D    +  +   ++ P
Sbjct: 425 ADVQENVMEYLHVLSRP 441


>gi|210147462 von Willebrand factor A domain containing 5B1 [Homo
           sapiens]
          Length = 1215

 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 16/230 (6%)

Query: 287 FVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQE 346
           F+ID S SM+G  + + K+A+L  L+ +      N I F     +        + ++L  
Sbjct: 364 FLIDRSSSMSGISMHRVKDAMLVALKSLMPACLFNIIGFGSTFKSLFPSSQTYSEDSLAM 423

Query: 347 ARTFVKSME-DKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRP 405
           A   ++ M+ D G TNI   L   I      +  HR   R   ++ ++TDG  N      
Sbjct: 424 ACDDIQRMKADMGGTNILSPLKWVI-----RQPVHRGHPR---LLFVITDGAVN----NT 471

Query: 406 EKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQGFYE 465
            K+ E VRN        Y+ G G N+ +  ++ +A  + G A  + E      ++    +
Sbjct: 472 GKVLELVRNH-AFSTRCYSFGIGPNVCHRLVKGLASVSEGSAELLMEGERLQPKMVKSLK 530

Query: 466 EVANPLLTGVEME--YPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMN 513
           +   P+L+ V +E  +PE   + ++  +    + G  +V  G + D  ++
Sbjct: 531 KAMAPVLSDVTVEWIFPETTEVLVSPVSASSLFPGERLVGYGIVCDASLH 580


>gi|38195082 BCSC-1 isoform 2 [Homo sapiens]
          Length = 415

 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 73/340 (21%), Positives = 121/340 (35%), Gaps = 47/340 (13%)

Query: 64  TMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVSQGK 123
           T+   N      E  F   + + + + +F   +DG      +++K  A+  YEKA+SQG 
Sbjct: 36  TLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIVAELQDKMKARTNYEKAISQGH 95

Query: 124 TAGLVKASGRKLEKFTVSV-NVAAGSKVTFELTY-EELLKRHKGKYEMYLK--------- 172
            A L++      + F+ +V N+  GSK    L Y +EL     G     L          
Sbjct: 96  QAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLKYVQELPLEADGALRFVLPAVLNPRYQF 155

Query: 173 ---------------VQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKS- 216
                          V  + L     +   I    GI  + +       + LG   T + 
Sbjct: 156 SGSSKDSCLNVKTPIVPVEDLPYTLSMVATIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQ 215

Query: 217 FSGKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQ 276
            S   GH       D+        + +      +   +    PG++       V F+ P 
Sbjct: 216 VSLAAGH-----KFDRDVELLIYYNEVHTPSVVLEMGMPNMKPGHLMGDPSAMVSFY-PN 269

Query: 277 GLPVVPKNVA----FVIDISGSM---------AGRKLEQTKEALLRILEDMQEEDYLNFI 323
                P N      F++D SGSM         +  +++  KE L+ +L+ +    Y N  
Sbjct: 270 IPEDQPSNTCGEFIFLMDRSGSMQSPMSSQDTSQLRIQAAKETLILLLKSLPIGCYFNIY 329

Query: 324 LFSGDVSTWKEHLVQATPENLQEARTFVKSME-DKGMTNI 362
            F           V+ T + ++EA   VK M+ D G T I
Sbjct: 330 GFGSSYEACFPESVKYTQQTMEEALGRVKLMQADLGGTEI 369


>gi|218505703 von Willebrand factor A domain containing 3A [Homo
           sapiens]
          Length = 1184

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 23/102 (22%), Positives = 48/102 (47%)

Query: 280 VVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQA 339
           V  K V  ++DIS + +   +       L + E +  +D  N I F   + +W+  +V  
Sbjct: 507 VCEKRVVVLLDISATNSMYIIHIQHSLRLLLEEQLSNKDCFNLIAFGSTIESWRPEMVPV 566

Query: 340 TPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHR 381
           +  NLQ A  +  ++  +G  N+   L + + +  K +++H+
Sbjct: 567 SHNNLQSAWRWALNLRCRGSRNVLSALRKAVEVDFKDKDKHQ 608



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 23/96 (23%), Positives = 50/96 (52%), Gaps = 8/96 (8%)

Query: 285 VAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGD--VSTWKEHLVQATPE 342
           V+ +ID+S   +G + E+ ++ L+ ++++        F+L  G    S W + + + +  
Sbjct: 171 VSILIDVSAISSGPQKEEFQKDLMSLIDEQLSHKEKLFVLSFGTNAGSLWPDPM-EVSAS 229

Query: 343 NLQEARTFVKSMEDKGMTNINDGL-----LRGISML 373
            LQE + +VK+++  G +N+   L     L+G+  L
Sbjct: 230 TLQELKLWVKTLQPDGGSNLLQALKKIFTLKGLDSL 265


>gi|110578649 cache domain containing 1 [Homo sapiens]
          Length = 1223

 Score = 38.1 bits (87), Expect = 0.037
 Identities = 28/132 (21%), Positives = 56/132 (42%), Gaps = 7/132 (5%)

Query: 283 KNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVST------WKEHL 336
           K++  ++D   S+   +L+  K+A   IL  + E D ++ +  +  V T      +K  L
Sbjct: 176 KHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFL 235

Query: 337 VQATPENLQEARTFVKSMEDK-GMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTD 395
             AT E  ++  TFV S++     T    G  +   ++       +    +  ++I L+ 
Sbjct: 236 SPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSA 295

Query: 396 GDANVGESRPEK 407
           G  +   S  +K
Sbjct: 296 GITSKDSSEEDK 307


>gi|65507253 hypothetical protein LOC55196 [Homo sapiens]
          Length = 1747

 Score = 36.2 bits (82), Expect = 0.14
 Identities = 39/155 (25%), Positives = 65/155 (41%), Gaps = 14/155 (9%)

Query: 103  GNVKEKEVAKKQYEKAVSQGKTAGLVKASG------------RKLEKFTVSVNV-AAGSK 149
            GNV + EV KK+++K   +G      K                K+   T SV+  A+ SK
Sbjct: 1380 GNVLDMEVKKKKHDKQEQKGSVGATFKLGDSLSNPNERAIVKEKMVSNTKSVDTKASSSK 1439

Query: 150  VTFELTYEELLKRHKGKYEMYLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLL 209
             +  LT +E L+R K K  +  K   K  VK+   + +   P  ++ +  E+   +N+  
Sbjct: 1440 FSRILTPKEYLQRQKHKEALSNKASKKICVKNVPCDSEHMRPSKLA-VQVESCGKSNEKH 1498

Query: 210  GSALTKSFSGKKGHVSFKPSLDQQRSCPTCTDSLL 244
             S +  S     G  S   +L    S  + T ++L
Sbjct: 1499 SSGVQTSKESLNGLTSHGKNLKIHHSQESKTYNIL 1533


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 33.9 bits (76), Expect = 0.69
 Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 3/73 (4%)

Query: 384 ERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALEN 443
           E ST +V ++TDG +N G+ RP  I  ++R++ G +   + +  GN    N + +   E 
Sbjct: 185 ENSTKVVFLITDGYSNGGDPRP--IAASLRDS-GVEIFTFGIWQGNIRELNDMASTPKEE 241

Query: 444 HGFARRIYEDSDA 456
           H +    +E+ +A
Sbjct: 242 HCYLLHSFEEFEA 254


>gi|224831239 integrin alpha M isoform 1 precursor [Homo sapiens]
          Length = 1153

 Score = 33.5 bits (75), Expect = 0.90
 Identities = 28/125 (22%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 274 APQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWK 333
           A +G P    ++AF+ID SGS+      + KE +  ++E +++   L  ++   +   ++
Sbjct: 140 ALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSE--EFR 197

Query: 334 EHLVQATPENLQEARTFVKSMED-KGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIM 392
            H      +N    R+ VK +    G T+   G+ + +  L       R  + +  I+++
Sbjct: 198 IHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGAR--KNAFKILVV 255

Query: 393 LTDGD 397
           +TDG+
Sbjct: 256 ITDGE 260


>gi|88501734 integrin alpha M isoform 2 precursor [Homo sapiens]
          Length = 1152

 Score = 33.5 bits (75), Expect = 0.90
 Identities = 28/125 (22%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 274 APQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWK 333
           A +G P    ++AF+ID SGS+      + KE +  ++E +++   L  ++   +   ++
Sbjct: 140 ALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSE--EFR 197

Query: 334 EHLVQATPENLQEARTFVKSMED-KGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIM 392
            H      +N    R+ VK +    G T+   G+ + +  L       R  + +  I+++
Sbjct: 198 IHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGAR--KNAFKILVV 255

Query: 393 LTDGD 397
           +TDG+
Sbjct: 256 ITDGE 260


>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
          Length = 4242

 Score = 33.5 bits (75), Expect = 0.90
 Identities = 20/72 (27%), Positives = 33/72 (45%), Gaps = 10/72 (13%)

Query: 575  GEEKENLTARALDLSLKYHF----------VTPLTSMVVTKPEDNEDERAIADKPGEDAE 624
            G E+  +T   L+   KY            V P++++ VT P+++ DE     +PG +A 
Sbjct: 2458 GGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAP 2517

Query: 625  ATPVSPAMSYLT 636
              P  P +  LT
Sbjct: 2518 GPPEEPLLGELT 2529


>gi|169646281 coiled-coil domain containing 14 [Homo sapiens]
          Length = 912

 Score = 32.7 bits (73), Expect = 1.5
 Identities = 33/133 (24%), Positives = 63/133 (47%), Gaps = 11/133 (8%)

Query: 284 NVAFVIDISGSMAGRKLEQTK-EALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPE 342
           N++    +  S+  ++L Q+K E LL+++E+ ++E+     +F     T  E+  Q   E
Sbjct: 490 NMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIE 549

Query: 343 ------NLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERS----TSIVIM 392
                  L+EA   VKS + K  T   +  + GI++  +  E  R+ E +    TS+  +
Sbjct: 550 ITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRTLQTSMAKL 609

Query: 393 LTDGDANVGESRP 405
           L+D   +    +P
Sbjct: 610 LSDLSVDSARCKP 622


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 31.6 bits (70), Expect = 3.4
 Identities = 32/136 (23%), Positives = 55/136 (40%), Gaps = 20/136 (14%)

Query: 112 KKQYEKAVSQGKTAGLV--KASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEM 169
           K  ++  + +G+   +V  +A+   + + TV V+V A           E  K++ GK E 
Sbjct: 56  KSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLA-----------ERCKKNNGKAEF 104

Query: 170 YLKVQPK----QLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVS 225
           +L +QP+      V++F  +VD  +       + EA F T +  G+         K H  
Sbjct: 105 WLDLQPQAKVLMSVQYFLEDVDCKQSM---RSEDEAKFPTMNRRGAIKQAKIHYIKNHEF 161

Query: 226 FKPSLDQQRSCPTCTD 241
                 Q   C  C D
Sbjct: 162 IATFFGQPTFCSVCKD 177


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 31.6 bits (70), Expect = 3.4
 Identities = 32/136 (23%), Positives = 55/136 (40%), Gaps = 20/136 (14%)

Query: 112 KKQYEKAVSQGKTAGLV--KASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEM 169
           K  ++  + +G+   +V  +A+   + + TV V+V A           E  K++ GK E 
Sbjct: 56  KSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLA-----------ERCKKNNGKAEF 104

Query: 170 YLKVQPK----QLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVS 225
           +L +QP+      V++F  +VD  +       + EA F T +  G+         K H  
Sbjct: 105 WLDLQPQAKVLMSVQYFLEDVDCKQSM---RSEDEAKFPTMNRRGAIKQAKIHYIKNHEF 161

Query: 226 FKPSLDQQRSCPTCTD 241
                 Q   C  C D
Sbjct: 162 IATFFGQPTFCSVCKD 177


>gi|119703749 hydrocephalus inducing isoform a [Homo sapiens]
          Length = 5120

 Score = 31.6 bits (70), Expect = 3.4
 Identities = 36/139 (25%), Positives = 59/139 (42%), Gaps = 14/139 (10%)

Query: 532  EEVDMKEMEKALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGE-EKENLTARALDLSL 590
            E ++ +  EK   ER+      +E+L A       LE+R +  GE E+++   +  DL +
Sbjct: 2513 ERLEKERTEKERLEREKAERERLEKLRA-------LEERSDWEGEGEEDHEGKKEKDLGV 2565

Query: 591  KYHFV-TPLTSMVVTKPEDNEDE----RAIADKPGEDAEATPVSP-AMSYLTSYQPPQNP 644
             +  + TP    +  K     D+      I D  G  A   P+ P A+  + SY   + P
Sbjct: 2566 PFLDIQTPDFEGLSWKQALESDKLPKGEQILDILGLGASGPPIPPPALFSIVSYPVKRPP 2625

Query: 645  YYYVDGDPHFIIQIPEKDD 663
                D   HF+  IP  +D
Sbjct: 2626 LTMTDDLEHFVFVIPPSED 2644


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,559,248
Number of Sequences: 37866
Number of extensions: 1449849
Number of successful extensions: 3841
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 3761
Number of HSP's gapped (non-prelim): 59
length of query: 890
length of database: 18,247,518
effective HSP length: 111
effective length of query: 779
effective length of database: 14,044,392
effective search space: 10940581368
effective search space used: 10940581368
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.