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Search of human proteins with 51558724
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51558724 ADAM metallopeptidase with thrombospondin type 1
motif, 12 preproprotein [Homo sapiens]
(1594 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 3412 0.0
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 1302 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 720 0.0
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 656 0.0
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 641 0.0
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 635 0.0
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 560 e-159
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 546 e-155
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 534 e-151
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 527 e-149
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 484 e-136
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 468 e-131
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 459 e-128
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 456 e-128
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 437 e-122
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 435 e-121
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 430 e-120
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 397 e-110
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 380 e-105
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 372 e-102
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 372 e-102
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 352 2e-96
gi|145309328 papilin [Homo sapiens] 273 1e-72
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 229 1e-59
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 214 4e-55
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 214 4e-55
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 201 6e-51
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 197 9e-50
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 189 2e-47
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 189 2e-47
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 3412 bits (8847), Expect = 0.0
Identities = 1594/1594 (100%), Positives = 1594/1594 (100%)
Query: 1 MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRV 60
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRV
Sbjct: 1 MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRV 60
Query: 61 DASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIME 120
DASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIME
Sbjct: 61 DASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIME 120
Query: 121 KRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK 180
KRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK
Sbjct: 121 KRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVK 180
Query: 181 KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRR 240
KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRR
Sbjct: 181 KHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRR 240
Query: 241 SISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLIL 300
SISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLIL
Sbjct: 241 SISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLIL 300
Query: 301 LEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCET 360
LEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCET
Sbjct: 301 LEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCET 360
Query: 361 LGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMS 420
LGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMS
Sbjct: 361 LGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMS 420
Query: 421 RQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQL 480
RQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQL
Sbjct: 421 RQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQL 480
Query: 481 QYGPNATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPES 540
QYGPNATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPES
Sbjct: 481 QYGPNATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPES 540
Query: 541 IPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEA 600
IPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEA
Sbjct: 541 IPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEA 600
Query: 601 PTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFE 660
PTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFE
Sbjct: 601 PTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFE 660
Query: 661 GGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIG 720
GGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIG
Sbjct: 661 GGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIG 720
Query: 721 LIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDL 780
LIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDL
Sbjct: 721 LIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDL 780
Query: 781 EKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTC 840
EKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTC
Sbjct: 781 EKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTC 840
Query: 841 GTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGP 900
GTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGP
Sbjct: 841 GTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGP 900
Query: 901 HGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSC 960
HGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSC
Sbjct: 901 HGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSC 960
Query: 961 GGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLK 1020
GGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLK
Sbjct: 961 GGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLK 1020
Query: 1021 PVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRY 1080
PVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRY
Sbjct: 1021 PVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRY 1080
Query: 1081 LISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPV 1140
LISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPV
Sbjct: 1081 LISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPV 1140
Query: 1141 TPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPL 1200
TPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPL
Sbjct: 1141 TPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPL 1200
Query: 1201 TPDLSRESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPS 1260
TPDLSRESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPS
Sbjct: 1201 TPDLSRESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPS 1260
Query: 1261 GKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVG 1320
GKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVG
Sbjct: 1261 GKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVG 1320
Query: 1321 NWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNC 1380
NWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNC
Sbjct: 1321 NWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNC 1380
Query: 1381 SGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCG 1440
SGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCG
Sbjct: 1381 SGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCG 1440
Query: 1441 GGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVP 1500
GGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVP
Sbjct: 1441 GGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVP 1500
Query: 1501 SEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSV 1560
SEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSV
Sbjct: 1501 SEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSV 1560
Query: 1561 PTVRAECCFSCPQTHITHTQRQRRQRLLQKSKEL 1594
PTVRAECCFSCPQTHITHTQRQRRQRLLQKSKEL
Sbjct: 1561 PTVRAECCFSCPQTHITHTQRQRRQRLLQKSKEL 1594
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 1302 bits (3369), Expect = 0.0
Identities = 735/1718 (42%), Positives = 942/1718 (54%), Gaps = 231/1718 (13%)
Query: 24 LCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRD 83
LC PGP P R E G +V PVRVDA G FLSY L +P + RKRD
Sbjct: 21 LCALAPGAPGPA--PGRATE----GRAALDIVHPVRVDAGGSFLSYEL-WP--RALRKRD 71
Query: 84 LDGSEDW-VYYRISHEEKDLFFNLTVNQGFLSNSYIME-KRYGNLSHVKMMASSAPLCHL 141
+ D +Y + + ++L FNLT NQ L+ ++ E +R G L + A + P CHL
Sbjct: 72 VSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHT-PACHL 130
Query: 142 SGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVP 201
G V G AA+SAC GL G FQL + D+FIEP+ P G PH+VY+RQ P
Sbjct: 131 LGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVYKRQ-AP 189
Query: 202 E--------TKEPTCGLKDSVNISQKQELW--REKWERHNLPSRSLSRRSISKERWVETL 251
E + TCG++ + ++E W R++W R L R L +RS+SKE+WVETL
Sbjct: 190 ERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRL--RRLHQRSVSKEKWVETL 247
Query: 252 VVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIV 311
VVAD KM+EYHG VESY+LTIMNMV GLFH+PSIGN IHI +VRL+LLE+EE+ LKI
Sbjct: 248 VVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKIT 307
Query: 312 HHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQ 371
HHA+ TL SFCKWQKSIN K D +P+HHD A+LLTRKD+CA NRPCETLGLSH++GMCQ
Sbjct: 308 HHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQ 367
Query: 372 PHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLT 431
PHRSC+INED+GLPLAFT+AHELGHSFGIQHDG NDCEPVG+ P+IMS QL YD PLT
Sbjct: 368 PHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLT 427
Query: 432 WSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQE 491
WS+CS +YITRFLDRGWG CLDD P K + + PGV+YDV HQC+LQYG + FC++
Sbjct: 428 WSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCED 487
Query: 492 VENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPW 551
++NVC TLWCSV C SKLDAA DGT+CGE KWC++G+C+ VG +PE++ GGW WS W
Sbjct: 488 MDNVCHTLWCSVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAW 547
Query: 552 SHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEF 611
S CSR+CG GVQSAER C P PK+ G+YC GERKR+RLCN+ C + P+FR +QCS F
Sbjct: 548 SICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHF 607
Query: 612 DTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCING 671
D + YK +L+ W P+ N +PCEL+CRP + F+EK+ DAV+DGTPC++ SR++CING
Sbjct: 608 DAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCING 667
Query: 672 ICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRV 731
ICK VGCD+EIDS A EDRCGVC G+GS+C TV F++ EG GYVD+GLIP GAR+IR+
Sbjct: 668 ICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRI 727
Query: 732 MEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNE 791
E+ A NFLA+RSEDPEKY+LNGG+ IQWNG+Y++AGT F Y R+G+ E L + GPT E
Sbjct: 728 QEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTKE 787
Query: 792 SVWIQLLFQVTNPGIKYEYTIQKD-GLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTA- 849
VWIQLLFQ +NPG+ YEYTI ++ G ++V ++ W YG WT+C+VTCG G++RQ
Sbjct: 788 PVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVY 847
Query: 850 ------------HCIKKGRGMVKATFCDPETQPN----GRQKKCHEKA------------ 881
HC GR + C + P G + C
Sbjct: 848 CLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLC 907
Query: 882 ----------------------------------CPPRWWAGEWEACSATCGPHGEKKRT 907
CP W G W CS TCG G ++R
Sbjct: 908 IRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCG-EGTQRRN 966
Query: 908 VLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIR 967
VLC +++ +P C +P + ++C+ LC W +G G
Sbjct: 967 VLC-----TNDTGVP---CDEAQQPASEVTCSLP-LCR--WPLGTLGPEGSGSG------ 1009
Query: 968 SVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNG--KNPPTLKPVPP- 1024
+ +H+ + P+ A P P GT+ N + P L P
Sbjct: 1010 ----SSSHELFNEADFIPHHLA-------PRPSPASSPKPGTMGNAIEEEAPELDLPGPV 1058
Query: 1025 ---------------------PTSRPRMLTTPTG----PESMSTSTPAISSPSPTT---- 1055
P+ P + TG P + P+ SP P T
Sbjct: 1059 FVDDFYYDYNFINFHEDLSYGPSEEPDLDLAGTGDRTPPPHSHPAAPSTGSPVPATEPPA 1118
Query: 1056 ASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEEN-VSSSDTG-- 1112
A +EG LG W S P + R S S+ + ++ P E+ + + D G
Sbjct: 1119 AKEEGVLG--PWSPSPW-PSQAGR---SPPPPSEQTPGNPLINFLPEEDTPIGAPDLGLP 1172
Query: 1113 -----PTSEGGLVATTTSGSGL-------SSSRNPITW-------------------PVT 1141
S GL T S S S+ P W P
Sbjct: 1173 SLSWPRVSTDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGRGAPHL 1232
Query: 1142 PFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMP------ 1195
P + T P + S + V W + G PV+S P
Sbjct: 1233 PPRPSSTLPPLSPVGSTHSSPSPDVAELWTGGTVAWEPA-LEGGLGPVDSELWPTVGVAS 1291
Query: 1196 -LAPPLTP-------DLSRESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANT 1247
L PP+ P D S E P F T G Q T P + P
Sbjct: 1292 LLPPPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLPTTLTGLGHMPEPA 1351
Query: 1248 LLPLGGDHQPEP-------SGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLL 1300
L P G QPE S + + P N ++ ++P+ A SL G
Sbjct: 1352 LNP-GPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPL-----APSLAEAGPPA 1405
Query: 1301 NASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRC 1360
+ + +A W GNWSECSTTCGLGA WR V CS+ D DCA RP PA+RC
Sbjct: 1406 DPLVVR-------NAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRC 1458
Query: 1361 HLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCN 1420
HLRPCA W GNWSKCSR+C GG +R++QCVD+RD R LRPFHCQ PP C
Sbjct: 1459 HLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQ-PGPAKPPAHRPCG 1517
Query: 1421 PEPCEAWQVEPWSQCSRSCGGGVQERGVFCP-GGLCDWTKRPTSTMSCNEHLCCHWATGN 1479
+PC +W W +CS +CGGG Q+R V CP GLC+ RP +T CN H C W G
Sbjct: 1518 AQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPNTTRPCNTHPCTQWVVGP 1577
Query: 1480 WDLCSTSCGGGFQKRTVQCVPSE-GNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLL 1538
W CS CGGG Q+R V+CV ++ G ED DQ C H+ P + C + C+
Sbjct: 1578 WGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQ--CGHEAWPESSRPCGTEDCEPVEPPR 1635
Query: 1539 CTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC-PQTH 1575
C +D+LS FC+TL+ + +C +PT+R +CC SC P +H
Sbjct: 1636 CERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSH 1673
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 720 bits (1859), Expect = 0.0
Identities = 401/1005 (39%), Positives = 564/1005 (56%), Gaps = 57/1005 (5%)
Query: 42 QEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW-----VYYRIS 96
QE F+ L Y + P+RVD +G FLS+ + SRR+R +D + +++++S
Sbjct: 32 QEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKND-KHSRRRRSMDPIDPQQAVSKLFFKLS 90
Query: 97 HEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAA 156
K NLT+N F+S + +E Y + CH +G LQ A
Sbjct: 91 AYGKHFHLNLTLNTDFVSKHFTVE--YWGKDGPQWKHDFLDNCHYTG-YLQDQRSTTKVA 147
Query: 157 LSACHGLTGFFQLPHGDFFIEPVK------KHPLVEGGYHPHIVYRRQKVPETK---EPT 207
LS C GL G ++FIEP+K KH E G HPH++Y++ + +
Sbjct: 148 LSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENG-HPHVIYKKSALQQRHLYDHSH 206
Query: 208 CGLKDSVNISQKQELWREKWERHNLPSRSL-----SRRSISKERWVETLVVADTKMIEYH 262
CG+ D + L ++LP + +RS+S ER+VETLVVAD M+ YH
Sbjct: 207 CGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYH 266
Query: 263 GSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFC 322
G +++E YIL++MN+V L+ + S+GN ++I+V RLI+L E++ L+I HHA+K+L SFC
Sbjct: 267 GRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFC 326
Query: 323 KWQKSI-NPKSDLNPV------HHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRS 375
KWQKSI + +SD N + HHD AVL+TR DIC N+PC TLGL+ ++GMC+P RS
Sbjct: 327 KWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERS 386
Query: 376 CNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPY-IMSRQLQYDPTPLTWSK 434
C+INED GL AFTIAHE+GH+FG+ HDG N C G +M+ + + P +WS
Sbjct: 387 CSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSA 446
Query: 435 CSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVEN 494
CS +YIT FLD G G CLD+ P K+ +APG +YD QC+ QYG + C+ E
Sbjct: 447 CSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGE- 505
Query: 495 VCQTLWC-SVKGFCRSKLDAAADGTQCG----EKKWCMAGKCITVGKKPESIPGGWGRWS 549
VC+ LWC S C + AA+GT C EK WC G C+ G P+SI GGWG WS
Sbjct: 506 VCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWS 565
Query: 550 PWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCS 609
W CSRTCG GV S+ R C++P P GGKYC GERKRYR CN PC + FR+ QC+
Sbjct: 566 LWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCA 625
Query: 610 EFDTVPYKNELYHWFPIF-NPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVC 668
+FD +P++ + Y+W P PC L C F + AVIDGT C +S ++C
Sbjct: 626 DFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQC--NADSLDIC 683
Query: 669 INGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQK-EGSGYVDIGLIPKGAR 727
ING CK VGCD + S+A EDRC VC GDGS+C + F GY+++ IP+G+
Sbjct: 684 INGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSV 743
Query: 728 DIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGD-LEKLMAT 786
I V E+ + N++A++SE + YY+NG + I W + +AGT F Y R D E L A
Sbjct: 744 HIEVREVAMSKNYIALKSEG-DDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEAL 802
Query: 787 GPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRR 846
GPT+E++ + +L Q N GI+Y++ + + + + W + W+ECS TC G++R
Sbjct: 803 GPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTWNHQPWSECSATCAGGVQR 862
Query: 847 QTAHCIK-KGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKK 905
Q C + +V+ +CDP+++P Q+ C+ + CPP W+ G+W CS TC G +
Sbjct: 863 QEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTC-DGGMRT 921
Query: 906 RTVLCIQTM-VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGV 964
R VLCI+ + S+E+ L + C +P CN CP W +WSEC+ CG G
Sbjct: 922 RAVLCIRKIGPSEEETLDYSGCL-THRPVEKEPCNNQ-SCPPQWVALDWSECTPKCGPGF 979
Query: 965 RIRSVTCAKNHD-------EPCDVTRKPNSRALCGLQQCPSSRRV 1002
+ R V C K+ D C KP R C L +CP R V
Sbjct: 980 KHRIVLC-KSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
Score = 124 bits (312), Expect = 6e-28
Identities = 79/277 (28%), Positives = 110/277 (39%), Gaps = 28/277 (10%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKR-------CHLRPCAG-W 1368
W WSECS TC G + V C D+ DP + C+ PC W
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
Query: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA-W 1427
+G+W +CS+ C GG + R + C+ P CN + C W
Sbjct: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
Query: 1428 QVEPWSQCSRSCGGGVQERGVFC---------PGGLCDWTKRPTSTMSCNEHLCC--HWA 1476
WS+C+ CG G + R V C P C +P + C+ C W
Sbjct: 964 VALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
Query: 1477 TGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKS-- 1534
TG+W CS CG G Q RTVQC+ G + D C RPP ++C + C +
Sbjct: 1024 TGDWGQCSAQCGLGQQMRTVQCLSYTGQASSD-----CLETVRPPSMQQC-ESKCDSTPI 1077
Query: 1535 ADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
++ KD ++C + K CS R CC +C
Sbjct: 1078 SNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
Score = 42.4 bits (98), Expect = 0.004
Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 1/70 (1%)
Query: 1462 TSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPP 1521
T T S + + W W CS +C GG Q++ V C + N + C D KP P
Sbjct: 831 TRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKP-PE 889
Query: 1522 EFKKCNQQAC 1531
+ CN + C
Sbjct: 890 NQRACNTEPC 899
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 656 bits (1693), Expect = 0.0
Identities = 375/1016 (36%), Positives = 552/1016 (54%), Gaps = 85/1016 (8%)
Query: 51 EYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVNQ 110
+Y V PV VD++G ++S+ + + + R+KR + ++YR S ++L L +
Sbjct: 60 DYVFVTPVEVDSAGSYISHDI---LHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPS- 115
Query: 111 GFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLP 170
LS+ +I++ G + C G + + + A+S C GL+G +
Sbjct: 116 AILSSHFIVQV-LGKDGASETQKPEVQQCFYQGFIRNDSS--SSVAVSTCAGLSGLIRTR 172
Query: 171 HGDFFIEPVKKHPLVE------GGYHPHIVYRR------------------------QKV 200
+F I P+ + E G+HPH++Y+R +
Sbjct: 173 KNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHI 232
Query: 201 PET--------------KEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRRSISKER 246
P K+ CG + E +++ + R RRS K +
Sbjct: 233 PHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRP--RRSAGKSQ 290
Query: 247 W---VETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEE 303
VETLVVAD KM+E HG NV +YILT+MNMV+GLF + +IG+ I++VVV LILLE+
Sbjct: 291 KGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQ 350
Query: 304 EEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGL 363
E GL I HHA+++L+SFC+WQ ++ K N HD A+LLT DIC+ N PC+TLG
Sbjct: 351 EPGGLLINHHADQSLNSFCQWQSALIGK---NGKRHDHAILLTGFDICSWKNEPCDTLGF 407
Query: 364 SHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQL 423
+ +SGMC +RSC INED+GL LAFTIAHE GH+FG+ HDG+ N C + IMS L
Sbjct: 408 APISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGN--IMSPTL 465
Query: 424 QYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKG-LKSKVIAPGVIYDVHHQCQLQY 482
+ +WS CS +Y+ +FL CL D PK+ G K PG IYD QC+ Q+
Sbjct: 466 TGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQF 525
Query: 483 GPNATFCQE--VENVCQTLWCSVKGF-CRSKLDAAADGTQCGEKKWCMAGKCITVGKK-P 538
G A C V+++C++LWC G C +K AA+GT CG WC G+C+ G+ P
Sbjct: 526 GAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGP 585
Query: 539 ESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRS 598
I G W WS WS CSRTCG GV+ ER CNNP+P++GG +C G + Y+LCN++PC
Sbjct: 586 RPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNE 645
Query: 599 EAPTFRQMQCSEFDTVPYKNELYHWFPI--FNPAHPCELYCRPIDGQFSEKMLDAVIDGT 656
+ FR QC+E+++ P++ Y W P C+LYC+ + +F M V DGT
Sbjct: 646 NSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGT 705
Query: 657 PCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMF-KQKEGSG 715
PC N +VCI+G+C++VGCD+E+ S A D CGVC GD S+C+ + ++ Q + +
Sbjct: 706 PC--SPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANE 763
Query: 716 YVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYD 775
Y + LIP GAR I + E++ + ++LA+RS +KYYL GG+ I W G + AGT F+Y
Sbjct: 764 YYPVVLIPAGARSIEIQELQVSSSYLAVRSLS-QKYYLTGGWSIDWPGEFPFAGTTFEYQ 822
Query: 776 RKGDL-EKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQK--DGLDNDVEQQMYFWQYGH 832
R + E+L A GPTNE++ ++L Q NPGI ++Y + K +G ++ Y W
Sbjct: 823 RSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ 882
Query: 833 WTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWE 892
+ECSV+CG G A C++ V ++FC +T+P K C+ +CP W GEW
Sbjct: 883 -SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWS 941
Query: 893 ACSATCGPHGEKKRTVLCIQTM-VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVG 951
CS C G++ R + C+Q E+A+ + C + P + +CN CP W++G
Sbjct: 942 TCSKACA-GGQQSRKIQCVQKKPFQKEEAVLHSLCP-VSTPTQVQACNSH-ACPPQWSLG 998
Query: 952 NWSECSVSCGGGVRIRSVTCAKNHDE-----PCDVTRKPNSRALCGLQQCPSSRRV 1002
WS+CS +CG GVR R + C + E C +P + C L +CP + R+
Sbjct: 999 PWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRL 1054
Score = 110 bits (276), Expect = 8e-24
Identities = 74/233 (31%), Positives = 106/233 (45%), Gaps = 24/233 (10%)
Query: 1323 SECSTTCGLGAYWRRVEC----STQMDSD-CAAIQRP-DPAKRCHLRPC-AGWKVGNWSK 1375
SECS +CG G + C +TQ++S C+A +P K C+ C A W G WS
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
Query: 1376 CSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA-WQVEPWSQ 1434
CS+ C+GG + R+IQCV + + P +CN C W + PWSQ
Sbjct: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQ 1002
Query: 1435 CSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSCNEHLC-----CHWATGNWD 1481
CS++CG GV++R + C G C RP C C W +W
Sbjct: 1003 CSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWS 1062
Query: 1482 LCSTSCGGGFQKRTVQCVPS--EGNK-TEDQDQCLCDHKPRPPEFKKCNQQAC 1531
CS +CG G +KR ++C +G T + +C KP + CN++AC
Sbjct: 1063 ECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRAC 1115
Score = 110 bits (276), Expect = 8e-24
Identities = 82/298 (27%), Positives = 117/298 (39%), Gaps = 54/298 (18%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQ---------MDSDCAAIQRPDPAKRCHLRPC 1365
A+W+ G WS CS C G R+++C + + S C + P + C+ C
Sbjct: 933 AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCP-VSTPTQVQACNSHAC 991
Query: 1366 AG-WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC 1424
W +G WS+CS+ C G + RE+ C S L C L P L C C
Sbjct: 992 PPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAE-TLPESQCTSLPR--PELQEGCVLGRC 1048
Query: 1425 EA-----WQVEPWSQCSRSCGGGVQERGVFC------------PGGLCDWTKRPTSTM-- 1465
W WS+CS +CG GV++R + C P C K+P +
Sbjct: 1049 PKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEE 1108
Query: 1466 SCNEHLC---------CHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDH 1516
+CN C W + W C+ +CGGG Q R+V CV + CL
Sbjct: 1109 TCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV----QQGRPSSSCLLHQ 1164
Query: 1517 KPRPPEFKKCNQQAC---KKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
K PP + CN C +K D C ++C + C+ +CC SC
Sbjct: 1165 K--PPVLRACNTNFCPAPEKREDPSCVD---FFNWCHLVPQHGVCNHKFYGKQCCKSC 1217
Score = 101 bits (251), Expect = 7e-21
Identities = 62/194 (31%), Positives = 84/194 (43%), Gaps = 28/194 (14%)
Query: 1307 QLTNGHGSA-HWIVGNWSECSTTCGLGAYWRRVECS-----TQMDSDCAAIQRPDPAKRC 1360
Q N H W +G WS+CS TCG G R + C T +S C ++ RP+ + C
Sbjct: 984 QACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGC 1043
Query: 1361 HLRPCAG-----WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPP- 1414
L C W +WS+CS C G + RE++C + L F + I P
Sbjct: 1044 VLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPN 1103
Query: 1415 --LSMSCNPEPCEA---------WQVEPWSQCSRSCGGGVQERGVFC-----PGGLCDWT 1458
L +CN C A W PW QC+ +CGGGVQ R V C P C
Sbjct: 1104 LDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLH 1163
Query: 1459 KRPTSTMSCNEHLC 1472
++P +CN + C
Sbjct: 1164 QKPPVLRACNTNFC 1177
Score = 93.2 bits (230), Expect = 2e-18
Identities = 60/196 (30%), Positives = 89/196 (45%), Gaps = 20/196 (10%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP--- 884
W G W++CS TCG G+R++ C + + C +P Q+ C CP
Sbjct: 995 WSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPE-LQEGCVLGRCPKNSR 1053
Query: 885 -RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQ-ALPPTDCQHLLKPKTLL--SCNR 940
+W A W CSATCG G +KR + C + + P C+++ KP L +CNR
Sbjct: 1054 LQWVASSWSECSATCGL-GVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNR 1112
Query: 941 DILCPSD--------WTVGNWSECSVSCGGGVRIRSVTCAK--NHDEPCDVTRKPNSRAL 990
CP+ W W +C+V+CGGGV+ RSV C + C + +KP
Sbjct: 1113 RA-CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRA 1171
Query: 991 CGLQQCPSSRRVLKPN 1006
C CP+ + P+
Sbjct: 1172 CNTNFCPAPEKREDPS 1187
Score = 38.5 bits (88), Expect = 0.052
Identities = 37/132 (28%), Positives = 51/132 (38%), Gaps = 18/132 (13%)
Query: 526 CMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGER 585
C+ G+C P++ W S WS CS TCG GV+ E C+ E F GK T
Sbjct: 1043 CVLGRC------PKNSRLQWVA-SSWSECSATCGLGVRKREMKCS--EKGFQGKLITFPE 1093
Query: 586 KRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFS 645
+R R P T + C P N + W+ + P C + C G
Sbjct: 1094 RRCRNIK-KPNLDLEETCNRRACPAH---PVYNMVAGWYSL--PWQQCTVTC---GGGVQ 1144
Query: 646 EKMLDAVIDGTP 657
+ + V G P
Sbjct: 1145 TRSVHCVQQGRP 1156
Score = 37.4 bits (85), Expect = 0.12
Identities = 38/115 (33%), Positives = 48/115 (41%), Gaps = 37/115 (32%)
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLA---GIPPPLSMSCNPEPC 1424
W+ G +K CS GF +++I C HR +F+ G LSM C C
Sbjct: 523 WQFGAKAKL---CSLGF-VKDI-CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQC 577
Query: 1425 ---------------EAWQVEPWSQCSRSCGGGV--QER----------GVFCPG 1452
AW WS+CSR+CGGGV QER G+FCPG
Sbjct: 578 VKFGELGPRPIHGQWSAWS--KWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPG 630
Score = 35.4 bits (80), Expect = 0.44
Identities = 28/100 (28%), Positives = 35/100 (35%), Gaps = 22/100 (22%)
Query: 1327 TTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAG-WKV-GNWSKCSRNCSGGF 1384
T CGL + R+ C P RP G W WS+CSR C GG
Sbjct: 564 TVCGLSMWCRQ--------GQCVKFGELGP------RPIHGQWSAWSKWSECSRTCGGGV 609
Query: 1385 KIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC 1424
K +E C N +P + + CN PC
Sbjct: 610 KFQERHC------NNPKPQYGGLFCPGSSRIYQLCNINPC 643
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 641 bits (1653), Expect = 0.0
Identities = 374/1012 (36%), Positives = 539/1012 (53%), Gaps = 79/1012 (7%)
Query: 40 RRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGS--EDWVYYRISH 97
R Q+ F+ L Y + P RVD +G L++ P RR+R G+ E ++Y+++
Sbjct: 27 RSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPP----RRQRRGTGATAESRLFYKVAS 82
Query: 98 EEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAAL 157
NLT + L+ +E Y + ++ P C +G LQ A+
Sbjct: 83 PSTHFLLNLTRSSRLLAGHVSVE--YWTREGLAWQRAARPHCLYAGH-LQGQASTSHVAI 139
Query: 158 SACHGLTGFFQLPHGDFFIEPVKKHPL-----VEGGYHPHIVYRRQKVPETKEPT-CGLK 211
S C GL G ++ IEP+ P E G PH+VY+R + T CG++
Sbjct: 140 STCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESG--PHVVYKRSSLRHPHLDTACGVR 197
Query: 212 DSVNISQKQELWREK-WERHNL---PSRSLS----------RRSISKERWVETLVVADTK 257
D ++ W+ + W L P+R L +RS+S+ER+VETLVVAD
Sbjct: 198 D-------EKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKM 250
Query: 258 MIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKT 317
M+ YHG +VE Y+L IMN+V LF + S+G+ ++I+V RLILL E++ L+I HHA K+
Sbjct: 251 MVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHAGKS 310
Query: 318 LSSFCKWQKSI-------NPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMC 370
L SFCKWQKSI N + +HD AVL+TR DIC N+PC TLGL+ + GMC
Sbjct: 311 LDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVGGMC 370
Query: 371 QPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPY-IMSRQLQYDPTP 429
+ RSC++NED GL AFTIAHE+GH+FG+ HDG N C G+ P +M+ + P
Sbjct: 371 ERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHITMKTNP 430
Query: 430 LTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFC 489
WS CS +YIT FLD G G CL++ P ++ +APG YD QC+ Q+G + C
Sbjct: 431 FVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQC 490
Query: 490 QEVENVCQTLWC-SVKGFCRSKLDAAADGTQCG----EKKWCMAGKCITVGKKPESIPGG 544
+ E VC LWC S C + AA+GT C +K WC C+ G +PE + G
Sbjct: 491 KYGE-VCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGA 549
Query: 545 WGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFR 604
WG W+PW CSRTCG GV S+ R C++P P GGKYC GER+R+R CN C + FR
Sbjct: 550 WGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFR 609
Query: 605 QMQCSEFDTVPYKNELYHWFPI-FNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGN 663
++QCSEFD++P++ + Y W C L C F + AV+DGTPC +
Sbjct: 610 EVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPC--RPD 667
Query: 664 SRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFK-QKEGSGYVDIGLI 722
+ ++C++G CK VGCD + S+ ED+C VC GDGS+C+T+ +F G+GY D+ I
Sbjct: 668 TVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWI 727
Query: 723 PKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGD-LE 781
PKG+ I + ++ + + LA++ D E L G LAGT FQ + D ++
Sbjct: 728 PKGSVHIFIQDLNLSLSHLALKG-DQESLLLEGLPGTPQPHRLPLAGTTFQLRQGPDQVQ 786
Query: 782 KLMATGPTNESVWIQLLFQVTNPGIKYEYT--IQKDGLDNDVEQQMYFWQYGHWTECSVT 839
L A GP N S+ + +L + P ++Y + I +D L Y W Y WT+CS
Sbjct: 787 SLEALGPINASLIVMVLARTELPALRYRFNAPIARDSL------PPYSWHYAPWTKCSAQ 840
Query: 840 CGTGIRRQTAHCIKK-GRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATC 898
C G + Q C + V +C ++ RQ+ C+ + CPP W G W CS +C
Sbjct: 841 CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC 900
Query: 899 GPHGEKKRTVLCIQTM-VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECS 957
G + R+V+C + + ++E+AL + C +P L +C+ CP +W +WSEC+
Sbjct: 901 DA-GVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEACHGP-TCPPEWAALDWSECT 957
Query: 958 VSCGGGVRIRSVTCAKNHDE-------PCDVTRKPNSRALCGLQQCPSSRRV 1002
SCG G+R R V C K+ D C KP + C L++CP +R V
Sbjct: 958 PSCGPGLRHRVVLC-KSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWV 1008
Score = 135 bits (340), Expect = 3e-31
Identities = 84/281 (29%), Positives = 123/281 (43%), Gaps = 35/281 (12%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQR-PDPAKRCHLRPCA-GW 1368
W W++CS C G+ + VEC Q+DS C+A + P + C+ PC W
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDW 888
Query: 1369 KVGNWSKCSRNCSGGFKIREIQC---VDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE 1425
VGNWS CSR+C G + R + C V + + + L C PP+ +C+ C
Sbjct: 889 VVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPR---PPVLEACHGPTCP 945
Query: 1426 A-WQVEPWSQCSRSCGGGVQERGVFC---------PGGLCDWTKRPTSTMSCNEHLC--C 1473
W WS+C+ SCG G++ R V C P C +P +TM CN C
Sbjct: 946 PEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPA 1005
Query: 1474 HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533
W G W CS CG G ++R+V+C G + + C RPP ++C +
Sbjct: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHE-----CTEALRPPTTQQCEAKCDSP 1060
Query: 1534 S---ADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
+ C KD ++C + + CS R CC +C
Sbjct: 1061 TPGDGPEEC-KDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
Score = 105 bits (261), Expect = 5e-22
Identities = 57/171 (33%), Positives = 81/171 (47%), Gaps = 12/171 (7%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCD---PETQPNGRQKKCHEKACPP 884
W G+W+ CS +C G+R ++ C ++ + D P+ +P + CH CPP
Sbjct: 888 WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEA-CHGPTCPP 946
Query: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQA-LPPTDCQHLLKPKTLLSCNRDIL 943
W A +W C+ +CGP G + R VLC +D +A LPP C KP + CN
Sbjct: 947 EWAALDWSECTPSCGP-GLRHRVVLCKS---ADHRATLPPAHCSPAAKPPATMRCNLRRC 1002
Query: 944 CPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE---PCDVTRKPNSRALC 991
P+ W G W ECS CG G R RSV C + + C +P + C
Sbjct: 1003 PPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQC 1053
Score = 100 bits (248), Expect = 1e-20
Identities = 54/181 (29%), Positives = 81/181 (44%), Gaps = 16/181 (8%)
Query: 1364 PCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
P W W+KCS C+GG +++ ++C + D + P +C + + P +CN EP
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKL-PKRQRACNTEP 883
Query: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHL-----CCH--- 1474
C W V WS CSRSC GV+ R V C + ++ +C + CH
Sbjct: 884 CPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPT 943
Query: 1475 ----WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQA 1530
WA +W C+ SCG G + R V C ++ T C +PP +CN +
Sbjct: 944 CPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRAT--LPPAHCSPAAKPPATMRCNLRR 1001
Query: 1531 C 1531
C
Sbjct: 1002 C 1002
Score = 45.4 bits (106), Expect = 4e-04
Identities = 18/52 (34%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVECST---QMDSDCAAIQRPDPAKRCHLR 1363
A W+ G W ECS CG+G R V C++ Q +C RP ++C +
Sbjct: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAK 1056
Score = 36.6 bits (83), Expect = 0.20
Identities = 31/124 (25%), Positives = 45/124 (36%), Gaps = 22/124 (17%)
Query: 1431 PWSQCSRSCGGGVQER------------GVFCPG-----GLCDWTKRPTSTMSCNEHLCC 1473
PW CSR+CGGGV G +C G C+ P + E C
Sbjct: 555 PWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCS 614
Query: 1474 HWAT----GNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKP-RPPEFKKCNQ 1528
+ + G + T GGG + ++ C+ N ++ + D P RP C
Sbjct: 615 EFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVS 674
Query: 1529 QACK 1532
CK
Sbjct: 675 GECK 678
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 635 bits (1638), Expect = 0.0
Identities = 377/1033 (36%), Positives = 540/1033 (52%), Gaps = 82/1033 (7%)
Query: 30 PQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSE- 88
P+P P P R KG EY +V VD G ++S+ + + RR+R + SE
Sbjct: 43 PRPPP---PAERPGWMEKG--EYDLVSAYEVDHRGDYVSHEIMH---HQRRRRAVPVSEV 94
Query: 89 DWVYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQ 148
+ ++ R+ D +L + ++ +I++ + C G++ +
Sbjct: 95 ESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSL--R 152
Query: 149 GTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKH------PLVEGGYHPHIVYRRQKVPE 202
R + ALS C GL+G + D+F+ P+ H +G H++Y+R P
Sbjct: 153 SHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPH 212
Query: 203 TK----------------EPTCGLKDSVNISQKQELW--REKW-------ERHNLPS--- 234
+P + + QKQ R+K+ + LP
Sbjct: 213 APGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYK 272
Query: 235 ------RSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIG 288
RSL R ++E VETLVV D KM++ HG EN+ +Y+LTI+NMV+ LF + +IG
Sbjct: 273 SCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIG 332
Query: 289 NAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRK 348
I+I +V LILLE+E+ GL I HHA+ TLSSFC+WQ + K + HD A+LLT
Sbjct: 333 GNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGK---DGTRHDHAILLTGL 389
Query: 349 DICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKEND 408
DIC+ N PC+TLG + +SGMC +RSC INED+GL LAFTIAHE GH+FG+ HDG+ N
Sbjct: 390 DICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNM 449
Query: 409 CEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKK-KGLKSKVIA 467
C+ IMS L +WS CS +Y+ +FL CL D PK K K
Sbjct: 450 CKK--SEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKL 507
Query: 468 PGVIYDVHHQCQLQYGPNATFC--QEVENVCQTLWCSVKG-FCRSKLDAAADGTQCGEKK 524
PG +YD + QC+ Q+G A C +++C+ LWC G C +K AA+GT CG
Sbjct: 508 PGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDM 567
Query: 525 WCMAGKCITVGKK-PESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG 583
WC G+C+ G + P+ G W WS WS CSRTCG GV RLC NP+P GGK+C G
Sbjct: 568 WCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEG 627
Query: 584 ERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPI--FNPAHPCELYCRPID 641
+ +LCN C ++ FR QC+E ++ ++ Y W P C+LYC
Sbjct: 628 STRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEG 687
Query: 642 GQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSC 701
F + + V DGTPC E +SRNVCI+GIC+ VGCD + S+A ED CGVC G+ S+C
Sbjct: 688 FDFFFSLSNKVKDGTPCSE--DSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSAC 745
Query: 702 QTVRKMF-KQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQ 760
R ++ K + Y + IP GAR IR+ E+ + +++++R+ +YYLNG + +
Sbjct: 746 TIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNA-LRRYYLNGHWTVD 804
Query: 761 WNGNYKLAGTVFQYDRK-GDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDN 819
W G YK +GT F Y R + E L+ATGPTNE++ ++LLFQ NPG+ +EY++ + G +
Sbjct: 805 WPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEK 864
Query: 820 D-VEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCH 878
Q Y W +ECSV+CG G C + + V +FC+P+T+P C
Sbjct: 865 QPPAQPSYTWAIVR-SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCK 923
Query: 879 EKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC 938
ACPP W G W ACS TCG G + R V C + + D + +P + C P + +C
Sbjct: 924 VSACPPSWSVGNWSACSRTCG-GGAQSRPVQCTRRVHYDSEPVPASLCPQ-PAPSSRQAC 981
Query: 939 NRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH---------DEPCDVTRKPNSRA 989
N CP W+ G W+ECS +CG G R R+V C + D C KP
Sbjct: 982 NSQ-SCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
Query: 990 LCGLQQCPSSRRV 1002
C LQ+C +++
Sbjct: 1041 ACLLQRCHKPKKL 1053
Score = 112 bits (280), Expect = 3e-24
Identities = 83/307 (27%), Positives = 119/307 (38%), Gaps = 60/307 (19%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAI-----QRPDPAKR--CHLRPC-AGW 1368
W VGNWS CS TCG GA R V+C+ ++ D + +P P+ R C+ + C W
Sbjct: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAW 990
Query: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPP------LSMSCNPE 1422
G W++CS C G++ R + C + + P P L C+
Sbjct: 991 SAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKP 1050
Query: 1423 PCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCN---------EHLCC 1473
W V WSQCS +C G Q+R + C R ++ C+ E C
Sbjct: 1051 KKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACA 1110
Query: 1474 ------------------HWATGNWDLCSTSCGGGFQKRTVQCV----PSEGNKTEDQDQ 1511
W W C+ SCGGG Q R+VQC+ P+ G
Sbjct: 1111 PLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG-------- 1162
Query: 1512 CLCDHKPRPPEFKKCNQQAC--KKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCF 1569
CL KP CN C + D C KD +C + CS +CC
Sbjct: 1163 CLLHQKPSAS--LACNTHFCPIAEKKDAFC-KDYF--HWCYLVPQHGMCSHKFYGKQCCK 1217
Query: 1570 SCPQTHI 1576
+C ++++
Sbjct: 1218 TCSKSNL 1224
Score = 107 bits (268), Expect = 7e-23
Identities = 69/224 (30%), Positives = 90/224 (40%), Gaps = 27/224 (12%)
Query: 1323 SECSTTCGLGAYWRRVECSTQMD-----SDCAAIQRPDPAK-RCHLRPCA-GWKVGNWSK 1375
SECS +CG G R C + S C RP C + C W VGNWS
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
Query: 1376 CSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC-EAWQVEPWSQ 1434
CSR C GG + R +QC R H + P P +CN + C AW PW++
Sbjct: 939 CSRTCGGGAQSRPVQCT-RRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAE 997
Query: 1435 CSRSCGGGVQERGVFC------------PGGLCDWTKRPTSTMSCNEHLC-----CHWAT 1477
CS +CG G ++R V C P +C +P +C C W
Sbjct: 998 CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
Query: 1478 GNWDLCSTSCGGGFQKRTVQCVPS-EGNKTEDQDQCLCDHKPRP 1520
W CS +C G QKR ++C K + C H P+P
Sbjct: 1058 SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKP 1101
Score = 90.9 bits (224), Expect = 9e-18
Identities = 59/198 (29%), Positives = 83/198 (41%), Gaps = 26/198 (13%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRG----MVKATFCDPETQPNGRQ----KKCHE 879
W G W ECS TCG G R++ C ++ C E +P + ++CH
Sbjct: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCH- 1048
Query: 880 KACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE-QALPPTDCQHLLKPKTLLS- 937
K +W W CS TC G +KR + C + VS + + L C HL KP L
Sbjct: 1049 KPKKLQWLVSAWSQCSVTC-ERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
Query: 938 CNRDILCP------------SDWTVGNWSECSVSCGGGVRIRSVTC--AKNHDEPCDVTR 983
+ CP W WS+C+ SCGGGV+ RSV C C + +
Sbjct: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
Query: 984 KPNSRALCGLQQCPSSRR 1001
KP++ C CP + +
Sbjct: 1168 KPSASLACNTHFCPIAEK 1185
Score = 66.2 bits (160), Expect = 2e-10
Identities = 42/120 (35%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 1422 EPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRP-TSTMSCNEHLC 1472
+P W + S+CS SCGGG C L C+ RP T + C C
Sbjct: 869 QPSYTWAIVR-SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSAC 927
Query: 1473 C-HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W+ GNW CS +CGGG Q R VQC +E LC +P P + CN Q+C
Sbjct: 928 PPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP-QPAPSSRQACNSQSC 986
Score = 39.7 bits (91), Expect = 0.024
Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 26/103 (25%)
Query: 1441 GGVQERGVFCPGGLC----DWTKRPTSTMSCNEHLCCHWAT-GNWDLCSTSCGGGFQKRT 1495
G + ++C GG C D +PT HW+ +W CS +CGGG R+
Sbjct: 560 GTICGHDMWCRGGQCVKYGDEGPKPTHG---------HWSDWSSWSPCSRTCGGGVSHRS 610
Query: 1496 VQCV---PSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
C PS G K C+ R K CN Q C + +
Sbjct: 611 RLCTNPKPSHGGK-------FCEGSTR--TLKLCNSQKCPRDS 644
Score = 37.7 bits (86), Expect = 0.089
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 1311 GHGSAHWIVGNWSECSTTCGLGAYWRRVEC--STQMDSDCAAIQRPDPAKRCHLRPC 1365
G W WS+C+ +CG G R V+C + S C Q+P + C+ C
Sbjct: 1124 GPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFC 1180
Score = 35.8 bits (81), Expect = 0.34
Identities = 27/89 (30%), Positives = 36/89 (40%), Gaps = 12/89 (13%)
Query: 1432 WSQCSRSCGGGVQERGVFCP-------GGLCDWTKRPTSTMSCNEHLCCHWATG-NWDLC 1483
WS CSR+CGGGV R C G C+ + R + CN C + C
Sbjct: 595 WSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR--TLKLCNSQKCPRDSVDFRAAQC 652
Query: 1484 STSCGGGFQKRTVQCVPSEGNKTEDQDQC 1512
+ F+ R + P + EDQD C
Sbjct: 653 AEHNSRRFRGRHYKWKPY--TQVEDQDLC 679
Score = 34.3 bits (77), Expect = 0.99
Identities = 18/53 (33%), Positives = 22/53 (41%), Gaps = 2/53 (3%)
Query: 546 GRW--SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC 596
G W SPWS C+ +CG GVQ+ C G + CN H C
Sbjct: 1128 GSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFC 1180
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 560 bits (1442), Expect = e-159
Identities = 358/958 (37%), Positives = 495/958 (51%), Gaps = 87/958 (9%)
Query: 85 DGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPL------ 138
DG E V RI +DL+ L + FL+ + +E+R N A+SAP
Sbjct: 161 DGDE--VLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQR-PNPGPGPTGAASAPQPPAPPD 217
Query: 139 --CHLSGTVLQQGTRVGTAALSACHG-LTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVY 195
C +G VL+ + A+ S C G L GF QL FIEP+ + G HPH VY
Sbjct: 218 AGCFYTGAVLRHPGSL--ASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITG--HPHRVY 273
Query: 196 RRQKVPETKEPT--------CGL---KDSVNISQKQELWREKWERHNLPSRSLSRRSISK 244
R+++ E K CG+ K + E R K + LP +
Sbjct: 274 RQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLP----------Q 323
Query: 245 ERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEE 304
E +ET+VVAD M+ YHG++ +ILTI+NMV LF + S+ +++ V++LILL E
Sbjct: 324 EYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHET 383
Query: 305 EQGLKIVHHAEKTLSSFCKWQK-------------SINPKSDLNPVHHDVAVLLTRKDIC 351
L I HH EK L SFCKWQ S N D+ V D A+L+TRKD C
Sbjct: 384 PPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSV--DAAILITRKDFC 441
Query: 352 AGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEP 411
+ PC+T+G+++LSGMC R C I ED+GL LAFTIAHE+GH+ GI HD C
Sbjct: 442 VHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD 501
Query: 412 VGRHPYIMSRQ--LQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVI--- 466
G H IMS + + ++WS+CS+E + RFL CL + + S ++
Sbjct: 502 -GLH--IMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQ-TNPQSVNSVMVPSK 557
Query: 467 APGVIYDVHHQCQLQYGPNATFCQEVENV-CQTLWCSVKG--FCRSKLDAAADGTQCGEK 523
PG+ Y QCQ+ +GP A+FCQE+++V C LWC V+G CR+KLD DGT C
Sbjct: 558 LPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLG 617
Query: 524 KWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG 583
KWC AG+C + PE + G W WSP CSRTC AG+ S ER C P + C G
Sbjct: 618 KWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNG 672
Query: 584 ERKRYRLCNVHPCRSEAPTFRQMQCSEFDT-VPYKNELYHWFPIFNPAHPCELYCRPIDG 642
RK+YR+C PC + P FR QC + + W + + PC L+C P+
Sbjct: 673 PRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGK 732
Query: 643 QFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQ 702
+ + + V+DGT C G ++C NG C+ VGCD + S A ED CGVC G+G SC+
Sbjct: 733 EQPILLSEKVMDGTSC--GYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCK 790
Query: 703 TVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWN 762
++ F G+GYV++ +IP GAR I+V+E + A ++LA+R D K +N + I+ +
Sbjct: 791 IIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALR--DAGKQSINSDWKIEHS 848
Query: 763 GNYKLAGTVFQYDRKGDLEKLMATGPTNESV-WIQLLFQVTNPGIKYEYTIQKDGL---- 817
G + LAGT Y R+G EK+ A GPT + + LLFQ N G+ YEYTI D L
Sbjct: 849 GAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQ 908
Query: 818 DNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIK---KGRGMVKATFCDPETQPNGRQ 874
+ + ++ W + W +C TCG G R+ T C K K +V C T+P +
Sbjct: 909 SSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQI 968
Query: 875 KKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQ-ALPPTDCQHLLKPK 933
+KC+E+ C RW EW CS TCG G + R V C Q + + DC KP
Sbjct: 969 RKCNEQPCQTRWMMTEWTPCSRTCG-KGMQSRQVACTQQLSNGTLIRARERDCIG-PKPA 1026
Query: 934 TLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALC 991
+ C C + W G WSECSV CG G+R R+V C N + C ++ +P C
Sbjct: 1027 SAQRCEGQD-CMTVWEAGVWSECSVKCGKGIRHRTVRCT-NPRKKCVLSTRPREAEDC 1082
Score = 129 bits (325), Expect = 2e-29
Identities = 74/292 (25%), Positives = 125/292 (42%), Gaps = 30/292 (10%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD--------CAAIQRPDPA-KRCHLRPC-A 1366
W +W +C TCG G V C+ M + C + +P+P ++C+ +PC
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
Query: 1367 GWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC-E 1425
W + W+ CSR C G + R++ C + L + G P + C + C
Sbjct: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMT 1038
Query: 1426 AWQVEPWSQCSRSCGGGVQERGVFC--PGGLCDWTKRPTSTMSCNEHLCCH-WATGNWDL 1482
W+ WS+CS CG G++ R V C P C + RP C ++ C+ W G+W
Sbjct: 1039 VWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWSK 1098
Query: 1483 CSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADL-LCTK 1541
CS +CG G Q R +QC+ +K + C +P ++ C+ Q C + ++ T
Sbjct: 1099 CSITCGKGMQSRVIQCM----HKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITS 1154
Query: 1542 DKLSA-----------SFCQTLKAMKKCSVPTVRAECCFSCPQTHITHTQRQ 1582
+L+A +C+ ++ C CC +C + Q++
Sbjct: 1155 PRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQQK 1206
Score = 90.1 bits (222), Expect = 2e-17
Identities = 54/182 (29%), Positives = 78/182 (42%), Gaps = 27/182 (14%)
Query: 1364 PCAGWKVGNWSKCSRNCSGGFKIREIQC--VDSRDHRNLRPFHCQFLAGIPPPLSMSCNP 1421
P W +W C C GG + + C + S++ + C++L P P CN
Sbjct: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTK-PEPQIRKCNE 973
Query: 1422 EPCEA-WQVEPWSQCSRSCGGGVQERGVFCPGGLCDWT-----------KRPTSTMSCNE 1469
+PC+ W + W+ CSR+CG G+Q R V C L + T +P S C
Sbjct: 974 QPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEG 1033
Query: 1470 HLCCH-WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPE----FK 1524
C W G W CS CG G + RTV+C T + +C+ +PR E +
Sbjct: 1034 QDCMTVWEAGVWSECSVKCGKGIRHRTVRC-------TNPRKKCVLSTRPREAEDCEDYS 1086
Query: 1525 KC 1526
KC
Sbjct: 1087 KC 1088
Score = 62.0 bits (149), Expect = 4e-09
Identities = 39/135 (28%), Positives = 51/135 (37%), Gaps = 19/135 (14%)
Query: 1413 PPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFC-----------PGGLCDWTKRP 1461
P S PEP W W C +CGGG ++ V C C + +P
Sbjct: 905 PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKP 964
Query: 1462 TSTM-SCNEHLC-CHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKT---EDQDQCLCDH 1516
+ CNE C W W CS +CG G Q R V C N T + C+
Sbjct: 965 EPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCI--- 1021
Query: 1517 KPRPPEFKKCNQQAC 1531
P+P ++C Q C
Sbjct: 1022 GPKPASAQRCEGQDC 1036
Score = 43.1 bits (100), Expect = 0.002
Identities = 23/82 (28%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 802 TNPGIKYEYTIQ-KDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVK 860
TNP K + + ++ D + + Y W+ G W++CS+TCG G++ + C+ K G
Sbjct: 1064 TNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGR-H 1122
Query: 861 ATFCDPETQPNGRQKKCHEKAC 882
C +P + CH + C
Sbjct: 1123 GNECFSSEKP-AAYRPCHLQPC 1143
Score = 38.9 bits (89), Expect = 0.040
Identities = 20/55 (36%), Positives = 25/55 (45%), Gaps = 2/55 (3%)
Query: 547 RWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERK--RYRLCNVHPCRSE 599
R WS CS TCG G+QS C + G C K YR C++ PC +
Sbjct: 1092 RMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEK 1146
Score = 32.7 bits (73), Expect = 2.9
Identities = 21/65 (32%), Positives = 30/65 (46%), Gaps = 16/65 (24%)
Query: 1327 TTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKI 1386
T C LG + + EC+++ + P+ HL W + WS CSR CS G
Sbjct: 612 TDCDLGKWCKAGECTSRTSA-------PE-----HL--AGEWSL--WSPCSRTCSAGISS 655
Query: 1387 REIQC 1391
RE +C
Sbjct: 656 RERKC 660
Score = 31.6 bits (70), Expect = 6.4
Identities = 11/21 (52%), Positives = 13/21 (61%)
Query: 1432 WSQCSRSCGGGVQERGVFCPG 1452
WS CSR+C G+ R CPG
Sbjct: 642 WSPCSRTCSAGISSRERKCPG 662
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 546 bits (1406), Expect = e-155
Identities = 351/1036 (33%), Positives = 523/1036 (50%), Gaps = 104/1036 (10%)
Query: 41 RQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSED-W--------- 90
RQ ++ L EY +V P+RV+A G +H+ R +R ++ + D W
Sbjct: 37 RQVKLLETLSEYEIVSPIRVNALGEPFPTNVHF----KRTRRSINSATDPWPAFASSSSS 92
Query: 91 -----VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKR-YGNLSHVKMMASS-APLCHLSG 143
+YR+S + FNLT N GF++ + + ++ K + A L H
Sbjct: 93 STSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFY 152
Query: 144 TVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYH---PHIVYRR--- 197
TA +S C G+ G F+ GD+FIEP++ E PHI+YRR
Sbjct: 153 KGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAP 212
Query: 198 QKVPETKEPTCGLKDSVN--ISQKQELWREKW-ERHNLP--------------------- 233
Q+ P T C + N K++ KW ER NL
Sbjct: 213 QREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNK 272
Query: 234 --------SRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNP 285
+ ++R +S R+VE LVVAD +M+ YHG EN++ YILT+M++V ++ +P
Sbjct: 273 TDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDP 331
Query: 286 SIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLL 345
SIGN I+IV+V LI++ E+ G I +A+ TL +FC+WQ S K+ +HHD AVLL
Sbjct: 332 SIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHS---KNSPGGIHHDTAVLL 388
Query: 346 TRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGK 405
TR+DIC ++ C+TLGL+ L +C P+RSC+I+EDSGL AFTIAHELGH F + HD
Sbjct: 389 TRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDN 447
Query: 406 ENDCEPVG-RHP-YIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKS 463
N C+ G + P ++M+ L + P WSKCS +YIT FLD G+G CL + P+ +
Sbjct: 448 -NKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPL 506
Query: 464 KVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCS----VKGFCRSKLDAAADGTQ 519
V PG++Y+V+ QC+L +GP + C + C+ LWC+ V CR++ ADGT+
Sbjct: 507 PVQLPGILYNVNKQCELIFGPGSQVCPYMMQ-CRRLWCNNVNGVHKGCRTQHTPWADGTE 565
Query: 520 CGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGK 579
C K C G C+ G WG WSP+ CSRTCG G+++A R CN PEPK GGK
Sbjct: 566 CEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGK 625
Query: 580 YCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYK-NEL---YHWFPIFN---PAHP 632
YC G R +++ CN PC + FR QC+ FD + N L W P ++
Sbjct: 626 YCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDR 685
Query: 633 CELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCG 692
C+L+CR ++ D VIDGTPC G ++ ++C+ G+C+ GCD+ ++S A D+CG
Sbjct: 686 CKLFCRVAGNTAYYQLRDRVIDGTPC--GQDTNDICVQGLCRQAGCDHVLNSKARRDKCG 743
Query: 693 VCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAG-----NFLAIRSED 747
VC GD SSC+TV F GY + IP GA +I V + +G N+LA+ S
Sbjct: 744 VCGGDNSSCKTVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSK 802
Query: 748 PEKYYLNGGFIIQW-NGNYKLAGTVFQYD-RKGDLEKLMATGPTNESVWIQLLF--QVTN 803
E + LNG F++ ++ V +Y + +E++ +T + + +Q+L ++ N
Sbjct: 803 GE-FLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYN 861
Query: 804 PGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGM-VKAT 862
P ++Y + I + D QQ Y+ +G W CS C G R++ C ++ + V
Sbjct: 862 PDVRYSFNIPIE----DKPQQFYWNSHGPWQACSKPC-QGERKRKLVCTRESDQLTVSDQ 916
Query: 863 FCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALP 922
CD QP + C C RW CSA CG G + + C + D +
Sbjct: 917 RCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEK 974
Query: 923 PTD--CQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCD 980
D C KP C+ + W W+ECS SC GG + R C ++ D
Sbjct: 975 VDDGFCSSHPKPSNREKCSGE-CNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLD 1033
Query: 981 VTRKPNSRALCGLQQC 996
++ + + +Q+C
Sbjct: 1034 DSKCTHQEKVT-IQRC 1048
Score = 136 bits (342), Expect = 2e-31
Identities = 80/264 (30%), Positives = 103/264 (39%), Gaps = 51/264 (19%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVEC-----STQMDSDCAAIQRPDPAKRCHLRPCAGWKVG 1371
W G+W+ CS TCG G R V C S +S CA + RP + C + PC WK
Sbjct: 1186 WRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKAL 1245
Query: 1372 NWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC------- 1424
+WS CS C G R++ CV+ DH R C P C+ PC
Sbjct: 1246 DWSSCSVTCGQGRATRQVMCVNYSDHVIDRS-ECD--QDYIPETDQDCSMSPCPQRTPDS 1302
Query: 1425 ---------------------------EAWQVEPWSQCSRSCGGGVQERGVFC------P 1451
W+ PW CS +C GG Q R V C
Sbjct: 1303 GLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYT 1362
Query: 1452 GGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQ 1511
C +P +C C WA GNW C+ CGGG + R V C S G + D
Sbjct: 1363 ANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLS- 1421
Query: 1512 CLCDHKPRPPEFKKCNQQACKKSA 1535
C+ +PP+ ++CN AC A
Sbjct: 1422 --CEILDKPPDREQCNTHACPHDA 1443
Score = 133 bits (335), Expect = 1e-30
Identities = 74/233 (31%), Positives = 95/233 (40%), Gaps = 20/233 (8%)
Query: 1313 GSAHWIVGNWSECSTTCGLGAYWRRVECSTQMD---SDCAAIQRPDPAKRCHLRPCAGWK 1369
G W G W CS+TC G+ R V C + +DC +PD + C PC W
Sbjct: 1328 GGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWA 1387
Query: 1370 VGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC---EA 1426
GNW +C++ C GG + R + C S R C+ L PP CN C A
Sbjct: 1388 YGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILD--KPPDREQCNTHACPHDAA 1444
Query: 1427 WQVEPWSQCSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLCCHWATG 1478
W PWS CS SCG G ++R V+C C +P C C W G
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAG 1504
Query: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W CS SCG G Q+R V C + + C+ RP + C C
Sbjct: 1505 AWSQCSVSCGRGVQQRHVGCQIGTHKIARETE---CNPYTRPESERDCQGPRC 1554
Score = 131 bits (330), Expect = 5e-30
Identities = 77/234 (32%), Positives = 102/234 (43%), Gaps = 24/234 (10%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM-----DSDCAAIQRPDPAKRCHLRPC---AGW 1368
W GNW EC+ CG G R V C D C + +P ++C+ C A W
Sbjct: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAW 1445
Query: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQ 1428
G WS CS +C G K R + C+ ++D +L +C+ LA P C C W+
Sbjct: 1446 STGPWSSCSVSCGRGHKQRNVYCM-AKDGSHLESDYCKHLA--KPHGHRKCRGGRCPKWK 1502
Query: 1429 VEPWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSCNEHLC--CHWATG 1478
WSQCS SCG GVQ+R V C G C+ RP S C C W
Sbjct: 1503 AGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAE 1562
Query: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK 1532
W C+ +CG G + R V CV N+ CD RP + + C+ Q C+
Sbjct: 1563 EWQECTKTCGEGSRYRKVVCVDDNKNEVHG---ARCDVSKRPVDRESCSLQPCE 1613
Score = 129 bits (324), Expect = 2e-29
Identities = 76/267 (28%), Positives = 104/267 (38%), Gaps = 58/267 (21%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMD-----SDCAAIQRPDPAKRCHLRPCAG---- 1367
W +WS CS TCG G R+V C D S+C P+ + C + PC
Sbjct: 1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPD 1301
Query: 1368 ------------------------------WKVGNWSKCSRNCSGGFKIREIQCVDSRDH 1397
W+ G W CS C+GG + R + C +D
Sbjct: 1302 SGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVC---QDE 1358
Query: 1398 RNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFC------- 1450
C + I P +C PC W W +C++ CGGG++ R V C
Sbjct: 1359 NGYTANDC--VERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
Query: 1451 -PGGLCDWTKRPTSTMSCNEHLCCH---WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKT 1506
P C+ +P CN H C H W+TG W CS SCG G ++R V C+ +G+
Sbjct: 1417 FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHL 1476
Query: 1507 EDQDQCLCDHKPRPPEFKKCNQQACKK 1533
E C H +P +KC C K
Sbjct: 1477 ESD---YCKHLAKPHGHRKCRGGRCPK 1500
Score = 125 bits (313), Expect = 4e-28
Identities = 91/334 (27%), Positives = 130/334 (38%), Gaps = 59/334 (17%)
Query: 1291 TSLITEGFLLN---ASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVEC----STQ 1343
T + +GF + SN ++ + + W W+ECS +C G RR C +
Sbjct: 972 TEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV 1031
Query: 1344 MDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPF 1403
+D Q +RC PC WK G+WS+C C G K R++ C D N R
Sbjct: 1032 LDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMC 1091
Query: 1404 HCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL--------- 1454
+ P +C C +WQ PW QCS +CG G Q R V C G
Sbjct: 1092 DPE----TKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDND 1147
Query: 1455 CDWTKRPTSTMSCNEHLCCH-------------------WATGNWDLCSTSCGGGFQKRT 1495
C+ RPT T C E CH W G+W CS +CG G + R
Sbjct: 1148 CNAATRPTDTQDC-ELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRY 1206
Query: 1496 VQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK-------SADLLC-----TKDK 1543
V C G+ D+ C PRP ++C+ C + S + C T+
Sbjct: 1207 VSCRDENGSVA---DESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQV 1263
Query: 1544 LSASFCQTLKAMKKCS---VPTVRAECCFS-CPQ 1573
+ ++ + +C +P +C S CPQ
Sbjct: 1264 MCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQ 1297
Score = 123 bits (308), Expect = 2e-27
Identities = 70/233 (30%), Positives = 109/233 (46%), Gaps = 24/233 (10%)
Query: 1317 WIVGNWSECSTTCGLG--------AYWRRVECSTQMDSD--CAAIQRPDPAKRCHLR-PC 1365
W V + SECS CGLG A + R++ T+ D C++ +P ++C
Sbjct: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNT 998
Query: 1366 AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE 1425
GW+ W++CS++C GG + R CV++R+ L C + C+ PC
Sbjct: 999 GGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV-LDDSKCTHQEKVT---IQRCSEFPCP 1054
Query: 1426 AWQVEPWSQCSRSCGGGVQERGVFCPGG-------LCDWTKRPTSTMSCNEHLCCHWATG 1478
W+ WS+C +CG G + R V+C G +CD +PTS +C + C W G
Sbjct: 1055 QWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAG 1114
Query: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W CS +CG G+Q R V+C+ D + C+ RP + + C +C
Sbjct: 1115 PWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDND--CNAATRPTDTQDCELPSC 1165
Score = 118 bits (296), Expect = 4e-26
Identities = 80/265 (30%), Positives = 116/265 (43%), Gaps = 43/265 (16%)
Query: 1296 EGFLLNASNYKQLTNGHGSAH--------WIVGNWSECSTTCGLGAYWRRVECST----- 1342
+G L + K L HG W G WS+CS +CG G R V C
Sbjct: 1472 DGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKI 1531
Query: 1343 QMDSDCAAIQRPDPAKRCHLRPCA--GWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRN- 1399
+++C RP+ + C C W+ W +C++ C G + R++ CVD D++N
Sbjct: 1532 ARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVD--DNKNE 1589
Query: 1400 LRPFHCQFLAGIPPPLSMSCNPEPCE-AWQVEPWSQCSRSCGGGVQERGVFCPG---GLC 1455
+ C P SC+ +PCE W WS+CS +CG G ++R V C G
Sbjct: 1590 VHGARCD--VSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKE 1647
Query: 1456 DWTKRPTSTMSC------NEHLC--------CHWATGNWDLCSTSCGGGFQKRTVQCVPS 1501
++ +T++C + H C W GNW CS SCG G +R+VQC+ +
Sbjct: 1648 NYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN 1707
Query: 1502 EGNKTEDQDQCLCDHKPRPPEFKKC 1526
EDQ LC +P E K C
Sbjct: 1708 -----EDQPSHLCHTDLKPEERKTC 1727
Score = 114 bits (284), Expect = 1e-24
Identities = 68/200 (34%), Positives = 88/200 (44%), Gaps = 12/200 (6%)
Query: 825 MYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
+Y W+ W EC+ TCG G R + C+ + V CD +P R+ C + C
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRES-CSLQPCEY 1614
Query: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQA----LPPTDCQHLLKPKTLLSCNR 940
W GEW CS TCG G K+R V C + E +C P R
Sbjct: 1615 VWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
Query: 941 DILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEP---CDVTRKPNSRALC-GLQQC 996
D + W VGNW CSVSCG GV RSV C N D+P C KP R C + C
Sbjct: 1674 DCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
Query: 997 --PSSRRVLKPNKGTISNGK 1014
P + + +K KG +G+
Sbjct: 1734 ELPQNCKEVKRLKGASEDGE 1753
Score = 110 bits (276), Expect = 8e-24
Identities = 55/174 (31%), Positives = 85/174 (48%), Gaps = 11/174 (6%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W G W+ CSV+CG G +++ +C+ K +++ +C +P+G +KC C P+W
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHG-HRKCRGGRC-PKWK 1502
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSD 947
AG W CS +CG G ++R V C + + T+C +P++ C
Sbjct: 1503 AGAWSQCSVSCG-RGVQQRHVGC---QIGTHKIARETECNPYTRPESERDCQGPRCPLYT 1558
Query: 948 WTVGNWSECSVSCGGGVRIRSVTCAKN-----HDEPCDVTRKPNSRALCGLQQC 996
W W EC+ +CG G R R V C + H CDV+++P R C LQ C
Sbjct: 1559 WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 108 bits (269), Expect = 5e-23
Identities = 64/177 (36%), Positives = 83/177 (46%), Gaps = 14/177 (7%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACP--PR 885
W YG+W EC+ CG GIR + C + C+ +P R++ C+ ACP
Sbjct: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQ-CNTHACPHDAA 1444
Query: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCP 945
W G W +CS +CG G K+R V C M D L C+HL KP C R CP
Sbjct: 1445 WSTGPWSSCSVSCG-RGHKQRNVYC---MAKDGSHLESDYCKHLAKPHGHRKC-RGGRCP 1499
Query: 946 SDWTVGNWSECSVSCGGGVRIRSVTCAKN-----HDEPCDVTRKPNSRALCGLQQCP 997
W G WS+CSVSCG GV+ R V C + C+ +P S C +CP
Sbjct: 1500 K-WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Score = 101 bits (251), Expect = 7e-21
Identities = 61/208 (29%), Positives = 82/208 (39%), Gaps = 47/208 (22%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPR-- 885
W+ W+ CSVTCG G + C+ ++ + CD + P Q C CP R
Sbjct: 1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD-CSMSPCPQRTP 1300
Query: 886 -------------------------------WWAGEWEACSATCGPHGEKKRTVLCIQTM 914
W G W ACS+TC G ++R V+C
Sbjct: 1301 DSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAG-GSQRRVVVC---- 1355
Query: 915 VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKN 974
DE DC +KP +C CP W GNW EC+ CGGG+R R V C ++
Sbjct: 1356 -QDENGYTANDCVERIKPDEQRACESGP-CPQ-WAYGNWGECTKLCGGGIRTRLVVCQRS 1412
Query: 975 HDE-----PCDVTRKPNSRALCGLQQCP 997
+ E C++ KP R C CP
Sbjct: 1413 NGERFPDLSCEILDKPPDREQCNTHACP 1440
Score = 98.6 bits (244), Expect = 4e-20
Identities = 62/192 (32%), Positives = 86/192 (44%), Gaps = 31/192 (16%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W+ G W+EC VTCG G + + C + G + CDPET+P Q C + C W
Sbjct: 1056 WKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLNDRMCDPETKPTSMQT-CQQPECAS-WQ 1112
Query: 888 AGEWEACSATCGPHGEKKRTVLCI----QTMVSDEQ---ALPPTDCQHLLKPKTLLSCNR 940
AG W CS TCG G + R V CI ++V D A PTD Q P SC+
Sbjct: 1113 AGPWGQCSVTCG-QGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELP----SCHP 1167
Query: 941 DILCP-----------SDWTVGNWSECSVSCGGGVRIRSVTCAKNH-----DEPCDVTRK 984
P + W G+W+ CS +CG G R+R V+C + + C +
Sbjct: 1168 PPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPR 1227
Query: 985 PNSRALCGLQQC 996
P ++ C + C
Sbjct: 1228 PVAKEECSVTPC 1239
Score = 95.5 bits (236), Expect = 4e-19
Identities = 58/186 (31%), Positives = 86/186 (46%), Gaps = 22/186 (11%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W+Y WTECS +C G +R+ A C+ ++ + C + + ++C E CP +W
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVT--IQRCSEFPCP-QWK 1057
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSD 947
+G+W C TCG G K R V C E L C KP ++ +C + C S
Sbjct: 1058 SGDWSECLVTCG-KGHKHRQVWC----QFGEDRLNDRMCDPETKPTSMQTCQQP-ECAS- 1110
Query: 948 WTVGNWSECSVSCGGGVRIRSVTC------AKNHDEPCDVTRKPNSRALCGLQQC----- 996
W G W +CSV+CG G ++R+V C + D C+ +P C L C
Sbjct: 1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPA 1170
Query: 997 -PSSRR 1001
P +RR
Sbjct: 1171 APETRR 1176
Score = 83.2 bits (204), Expect = 2e-15
Identities = 54/202 (26%), Positives = 80/202 (39%), Gaps = 35/202 (17%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W++G WT CS TCG G R + C + + + C +P ++ +C C +W
Sbjct: 1186 WRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKE-ECSVTPC-GQWK 1243
Query: 888 AGEWEACSATCGPHGEKKRTVLC-------IQTMVSDEQALPPTD--------------- 925
A +W +CS TCG G R V+C I D+ +P TD
Sbjct: 1244 ALDWSSCSVTCG-QGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDS 1302
Query: 926 --CQHLL-----KPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHD-- 976
QH +P++ +L + W G W CS +C GG + R V C +
Sbjct: 1303 GLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYT 1362
Query: 977 -EPCDVTRKPNSRALCGLQQCP 997
C KP+ + C CP
Sbjct: 1363 ANDCVERIKPDEQRACESGPCP 1384
Score = 66.2 bits (160), Expect = 2e-10
Identities = 48/182 (26%), Positives = 73/182 (40%), Gaps = 22/182 (12%)
Query: 1371 GNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVE 1430
G W CS+ C G K R++ C D + C L P ++ C + W V
Sbjct: 885 GPWQACSKPCQGERK-RKLVCTRESDQLTVSDQRCDRLPQ-PGHITEPCGTDCDLRWHVA 942
Query: 1431 PWSQCSRSCGGGVQERGVFC-------------PGGLCDWTKRPTSTMSCN-EHLCCHWA 1476
S+CS CG G + ++C G C +P++ C+ E W
Sbjct: 943 SRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWR 1002
Query: 1477 TGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK--KS 1534
W CS SC GG Q+R CV + + +D C H+ + ++C++ C KS
Sbjct: 1003 YSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSK---CTHQEK-VTIQRCSEFPCPQWKS 1058
Query: 1535 AD 1536
D
Sbjct: 1059 GD 1060
Score = 31.2 bits (69), Expect = 8.4
Identities = 12/41 (29%), Positives = 22/41 (53%), Gaps = 2/41 (4%)
Query: 1404 HCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQ 1444
HC++ +P + + +W P+ CSR+CGGG++
Sbjct: 571 HCKYGFCVPKEMDVPVTDGSWGSWS--PFGTCSRTCGGGIK 609
Score = 31.2 bits (69), Expect = 8.4
Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 3/77 (3%)
Query: 547 RWSPWSHCSRTCGAGVQSAERLC--NNPEPKFGGKYCTGERKRYR-LCNVHPCRSEAPTF 603
R W C++TCG G + + +C +N G + +R R C++ PC T
Sbjct: 1560 RAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITG 1619
Query: 604 RQMQCSEFDTVPYKNEL 620
+CS YK L
Sbjct: 1620 EWSECSVTCGKGYKQRL 1636
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 534 bits (1375), Expect = e-151
Identities = 339/1021 (33%), Positives = 513/1021 (50%), Gaps = 88/1021 (8%)
Query: 41 RQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW---VYYRISH 97
RQE ++ L Y VV P RV+ G H+ SR+KR + E +YR +
Sbjct: 29 RQEALVRTLTSYEVVIPERVNEFGEVFPQSHHF----SRQKRSSEALEPMPFRTHYRFTA 84
Query: 98 EEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPL----CHLSGTVLQQGTRVG 153
+ NLT + FL+ Y E G + + P C G V Q
Sbjct: 85 YGQLFQLNLTADASFLAAGYT-EVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDY-- 141
Query: 154 TAALSACHGLTGFFQLPHGDFFIEPVKK---HPLVEGGYHPHIVYRRQ------------ 198
A +S C GLTG F+ +G++F+EP+ K + +G PH++YR+
Sbjct: 142 KAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYC 201
Query: 199 --KVPETKEPTCGLKDSVNISQKQELWREKWERH---NLPSR-----SLSRRSISKERWV 248
+ KE + N+++ + +E+ H N+P + S +R IS R++
Sbjct: 202 SVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYI 261
Query: 249 ETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGL 308
E +V AD K++ HGS N+++YILT+M++V ++ +PSIGN IHIVVV+L+++ EE+G
Sbjct: 262 EIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGP 320
Query: 309 KIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSG 368
I TL +FC WQ++ N D++P HHD AVL+TR+DIC+ + C LGLS+L
Sbjct: 321 VINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEK-CNMLGLSYLGT 379
Query: 369 MCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPT 428
+C P +SC INE+ GL AFTIAHELGH+ G+QHD E ++M+ L + +
Sbjct: 380 ICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMS 439
Query: 429 PLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATF 488
P +WS CS +Y+T FLD G+G CL D P ++ PG YD + QC+L +GP +
Sbjct: 440 PWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQM 499
Query: 489 CQEVENVCQTLWCSV-----KGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPG 543
C + N+C LWC+ KG C ++ ADGT CG C G C+ + + G
Sbjct: 500 CPHI-NICMHLWCTSTEKLHKG-CFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNG 557
Query: 544 GWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTF 603
WG W P+S CSRTCG G++SA R CN PEP+ GG YC G R ++R CN C F
Sbjct: 558 EWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDF 617
Query: 604 RQMQCSEFD----TVPYKNELYHWFPIFN---PAHPCELYCRPIDGQFSEKMLDAVIDGT 656
R+ QCS+F+ + W P ++ C+LYC+ + + D V DGT
Sbjct: 618 REKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGT 677
Query: 657 PCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGY 716
PC G + ++C+ G C GCD+ ++S+A D+CGVC GD SSC+T+ +F GY
Sbjct: 678 PC--GTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSH-YGY 734
Query: 717 VDIGLIPKGARDIRVMEIEGAG----NFLAIRSEDPEKYYLNGGFIIQWNG---NYKLAG 769
+ IP GA ++ + + +G ++LA+ S+ + NG F++ + N +
Sbjct: 735 NVVVKIPAGATNVDIRQYSYSGQPDDSYLAL-SDAEGNFLFNGNFLLSTSKKEINVQGTR 793
Query: 770 TVFQYDRKGD-LEKLMATGPTNESVWIQLLF--QVTNPGIKYEYTIQKDGLDNDVEQQMY 826
TV +Y + +E++ +T + + +Q+L + NP + Y + I + M+
Sbjct: 794 TVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPL-----EERSDMF 848
Query: 827 FWQ-YGHWTECSVTCGTGIRRQTAHCI-KKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
W YG W C+ C G++R+ CI K +V CD P+ + C+ C
Sbjct: 849 TWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD-CEL 906
Query: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD--CQHLLKPKTLLSCNRDI 942
RW CS+ CG G + + C++ + + Q + D C LKP T C+ +
Sbjct: 907 RWHVIGKSECSSQCG-QGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNC 965
Query: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH-----DEPCDVTRKPNSRALCGLQQCP 997
+ + W WS+CS SCGGG R R C N D C + +R C CP
Sbjct: 966 VF-TRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRV-TRENCNEFSCP 1023
Query: 998 S 998
S
Sbjct: 1024 S 1024
Score = 137 bits (346), Expect = 6e-32
Identities = 75/230 (32%), Positives = 105/230 (45%), Gaps = 22/230 (9%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECST---QMDSDCAAIQRPDPAKRCHLRPCAGWKVGNW 1373
W G W CS++C G R V C Q S C A +P ++C PC W GNW
Sbjct: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNW 1367
Query: 1374 SKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA---WQVE 1430
+CS+ C GG K R + C + + L +C+ + PP + C+ C A W E
Sbjct: 1368 GECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVN--KPPSVIQCHMHACPADVSWHQE 1424
Query: 1431 PWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSCNEHLCCHWATGNWDL 1482
PW+ CS SCG G + R VFC C ++P + +C C W +W+
Sbjct: 1425 PWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNE 1484
Query: 1483 CSTSCGGGFQKRTVQC-VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
CS +CG G Q+R V C + G E+ +CD RP ++C Q C
Sbjct: 1485 CSVTCGSGVQQRDVYCRLKGVGQVVEE----MCDQSTRPCSQRRCWSQDC 1530
Score = 129 bits (323), Expect = 3e-29
Identities = 77/244 (31%), Positives = 106/244 (43%), Gaps = 34/244 (13%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMD--SD--CAAIQRPDPAKRCHLRPCAGWKVGN 1372
W WSEC TCG G R+V C +D SD C + +P+ C L CA W+VG
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGP 1084
Query: 1373 WSKCSRNCSGGFKIREIQCV---------DSRDHRNLRPFH--------CQFLAGIPPPL 1415
W C+ C G+++R+++CV D+ H RP C F++ + L
Sbjct: 1085 WGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETAL 1144
Query: 1416 SMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSC 1467
+ + W+ W+ CS SCG G Q R V C L C RP C
Sbjct: 1145 LPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC 1204
Query: 1468 NEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCN 1527
C W G+W CS SCG G R V C+ N + D+ CD + RP ++C+
Sbjct: 1205 FTP-CGEWQAGDWSPCSASCGHGKTTRQVLCM----NYHQPIDENYCDPEVRPLMEQECS 1259
Query: 1528 QQAC 1531
AC
Sbjct: 1260 LAAC 1263
Score = 127 bits (320), Expect = 7e-29
Identities = 79/271 (29%), Positives = 118/271 (43%), Gaps = 30/271 (11%)
Query: 1279 KSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRV 1338
KS V+++++ L F+ Q N W V SECS+ CG G +
Sbjct: 876 KSDHSVVSDKECDHLPLPSFVT------QSCNTDCELRWHVIGKSECSSQCGQGYRTLDI 929
Query: 1339 EC---------STQMDSD-CAAIQRPDPAKRCHLRPC-AGWKVGNWSKCSRNCSGGFKIR 1387
C + Q+D C +P + CH W WS+CSR+C GG + R
Sbjct: 930 HCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSR 989
Query: 1388 EIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERG 1447
E C+++ HR L CQ L+ + +CN C +W WS+C +CG G ++R
Sbjct: 990 ESYCMNNFGHR-LADNECQELSRVTRE---NCNEFSCPSWAASEWSECLVTCGKGTKQRQ 1045
Query: 1448 VFCP-------GGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVP 1500
V+C G C+ + +P S C H C W G W C+T+CG G+Q R V+CV
Sbjct: 1046 VWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVN 1105
Query: 1501 SEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
+ + + C RP + + C C
Sbjct: 1106 ELASAVLEDTE--CHEASRPSDRQSCVLTPC 1134
Score = 126 bits (317), Expect = 1e-28
Identities = 88/314 (28%), Positives = 118/314 (37%), Gaps = 85/314 (27%)
Query: 1294 ITEGFLLNASNYKQLT--NGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQM------D 1345
+++GF +++ + L+ H A W VG W C+TTCG G R V+C ++ D
Sbjct: 1055 LSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLED 1114
Query: 1346 SDCAAIQRPDPAKRCHLRPC-------------------AGWKVGNWSKCSRNCSGGFKI 1386
++C RP + C L PC A W+ G+W+ CS +C G +
Sbjct: 1115 TECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQA 1174
Query: 1387 REIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQER 1446
R + C D+ D R + A +P P + PC WQ WS CS SCG G R
Sbjct: 1175 RYVSCRDALD----RIADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTR 1230
Query: 1447 GVFCPG-------GLCDWTKRPTSTMSC-------------------------------- 1467
V C CD RP C
Sbjct: 1231 QVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQK 1290
Query: 1468 ---NEHLCCH-------WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHK 1517
NE+ H W TG W CS+SC GG Q R V C G Q CD
Sbjct: 1291 LEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENG-----QSASYCDAA 1345
Query: 1518 PRPPEFKKCNQQAC 1531
+PPE ++C C
Sbjct: 1346 SKPPELQQCGPGPC 1359
Score = 114 bits (286), Expect = 6e-25
Identities = 65/176 (36%), Positives = 91/176 (51%), Gaps = 14/176 (7%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP--R 885
W YG+W ECS TCG GI+ + C +++ C+ +P +CH ACP
Sbjct: 1362 WNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPS-VIQCHMHACPADVS 1420
Query: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCP 945
W W +CSA+CG G K R V CI ++ L T+C + KP T +C R + CP
Sbjct: 1421 WHQEPWTSCSASCG-KGRKYREVFCIDQF---QRKLEDTNCSQVQKPPTHKAC-RSVRCP 1475
Query: 946 SDWTVGNWSECSVSCGGGVRIRSVTC-----AKNHDEPCDVTRKPNSRALCGLQQC 996
S W +W+ECSV+CG GV+ R V C + +E CD + +P S+ C Q C
Sbjct: 1476 S-WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
Score = 96.3 bits (238), Expect = 2e-19
Identities = 58/178 (32%), Positives = 85/178 (47%), Gaps = 16/178 (8%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W+ G W CS +C G++ + C + A++CD ++P Q+ C CP +W
Sbjct: 1308 WRTGPWGSCSSSCSGGLQHRAVVC--QDENGQSASYCDAASKPPELQQ-CGPGPCP-QWN 1363
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSD 947
G W CS TCG G K R V+C + Q L +C+ + KP +++ C+ CP+D
Sbjct: 1364 YGNWGECSQTCG-GGIKSRLVIC---QFPNGQILEDHNCEIVNKPPSVIQCHMH-ACPAD 1418
Query: 948 --WTVGNWSECSVSCGGGVRIRSVTC-----AKNHDEPCDVTRKPNSRALCGLQQCPS 998
W W+ CS SCG G + R V C K D C +KP + C +CPS
Sbjct: 1419 VSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPS 1476
Score = 95.1 bits (235), Expect = 5e-19
Identities = 62/217 (28%), Positives = 86/217 (39%), Gaps = 56/217 (25%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP--- 884
WQ G W+ CS +CG G + C+ + + +CDPE +P Q+ C ACPP
Sbjct: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNYHQP-IDENYCDPEVRPLMEQE-CSLAACPPAHS 1268
Query: 885 --------------------------------------RWWAGEWEACSATCGPHGEKKR 906
+W G W +CS++C G + R
Sbjct: 1269 HFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG-GLQHR 1327
Query: 907 TVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRI 966
V+C DE + C KP L C CP W GNW ECS +CGGG++
Sbjct: 1328 AVVC-----QDENGQSASYCDAASKPPELQQCGPGP-CPQ-WNYGNWGECSQTCGGGIKS 1380
Query: 967 RSVTCAKNH-----DEPCDVTRKPNSRALCGLQQCPS 998
R V C + D C++ KP S C + CP+
Sbjct: 1381 RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPA 1417
Score = 93.2 bits (230), Expect = 2e-18
Identities = 62/180 (34%), Positives = 83/180 (46%), Gaps = 17/180 (9%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIK----KGRGM-VKATFCDPETQPNGRQKKCHEKAC 882
W +ECS CG G R HC+K +G+ + V +C + +P Q+ CH
Sbjct: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPP-TQELCHGNCV 966
Query: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDI 942
RW EW CS +CG GE+ R C+ L +CQ L + T +CN +
Sbjct: 967 FTRWHYSEWSQCSRSCGG-GERSRESYCMNNF---GHRLADNECQELSRV-TRENCN-EF 1020
Query: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEP----CDVTRKPNSRALCGLQQCPS 998
CPS W WSEC V+CG G + R V C N D C+ + KP S + C L C S
Sbjct: 1021 SCPS-WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCAS 1079
Score = 92.4 bits (228), Expect = 3e-18
Identities = 55/177 (31%), Positives = 79/177 (44%), Gaps = 20/177 (11%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGR--QKKCHEKACPPR 885
W Y W++CS +CG G R + ++C+ D E Q R ++ C+E +CP
Sbjct: 970 WHYSEWSQCSRSCGGGERSRESYCMNN----FGHRLADNECQELSRVTRENCNEFSCPS- 1024
Query: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCP 945
W A EW C TCG G K+R V C + L C KP++L C ++
Sbjct: 1025 WAASEWSECLVTCG-KGTKQRQVWCQLNV----DHLSDGFCNSSTKPESLSPC--ELHTC 1077
Query: 946 SDWTVGNWSECSVSCGGGVRIRSVTCAKN------HDEPCDVTRKPNSRALCGLQQC 996
+ W VG W C+ +CG G ++R V C D C +P+ R C L C
Sbjct: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
Score = 88.6 bits (218), Expect = 4e-17
Identities = 66/235 (28%), Positives = 92/235 (39%), Gaps = 34/235 (14%)
Query: 787 GPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRR 846
G VW QL + G T + + L WQ G W C+ TCG G +
Sbjct: 1040 GTKQRQVWCQLNVDHLSDGFCNSST-KPESLSPCELHTCASWQVGPWGPCTTTCGHGYQM 1098
Query: 847 QTAHCIKK-GRGMVKATFCDPETQPNGRQK----KCH-----EKACPP--------RWWA 888
+ C+ + +++ T C ++P+ RQ C E A P +W
Sbjct: 1099 RDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRH 1158
Query: 889 GEWEACSATCGPHGEKKRTVLCIQTM--VSDEQALPPTDCQHLLKPKTLLSCNRDILCPS 946
G W CS +CG G + R V C + ++DE C HL +P + C
Sbjct: 1159 GSWTPCSVSCG-RGTQARYVSCRDALDRIADESY-----CAHLPRPAEIWDCFTPC---G 1209
Query: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNH----DEPCDVTRKPNSRALCGLQQCP 997
+W G+WS CS SCG G R V C H + CD +P C L CP
Sbjct: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACP 1264
Score = 85.1 bits (209), Expect = 5e-16
Identities = 52/168 (30%), Positives = 72/168 (42%), Gaps = 19/168 (11%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W W+EC VTCG G +++ C + + FC+ T+P C C W
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWC-QLNVDHLSDGFCNSSTKPESLSP-CELHTCAS-WQ 1081
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVS---------------DEQALPPTDCQHLLKP 932
G W C+ TCG HG + R V C+ + S D Q+ T C + K
Sbjct: 1082 VGPWGPCTTTCG-HGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL 1140
Query: 933 KTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCD 980
+T L I + W G+W+ CSVSCG G + R V+C D D
Sbjct: 1141 ETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIAD 1188
Score = 81.6 bits (200), Expect = 5e-15
Identities = 63/243 (25%), Positives = 98/243 (40%), Gaps = 36/243 (14%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQ-----MDSDCAAIQRPDPAKRCHLRPCA---GW 1368
W +W+ECS TCG G R V C + ++ C RP +RC + C G
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGM 1536
Query: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQ 1428
+ G + CS +C + ++C D++ + + + S +C PC
Sbjct: 1537 ERGRLN-CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLT---SKNCRNPPCNYIV 1592
Query: 1429 VEP-WSQCSRSCGGGVQERGVFC---------------PGGLCDWTKRPTSTMSCNEHLC 1472
V SQC+ +CG ++R +C P + P+S + + C
Sbjct: 1593 VTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSC 1652
Query: 1473 CH---WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQ 1529
H W G W CS +CG G KR V+C+ G ++ LC + +P KKC
Sbjct: 1653 LHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSD-----LCLNHLKPGAQKKCYAN 1707
Query: 1530 ACK 1532
CK
Sbjct: 1708 DCK 1710
Score = 57.4 bits (137), Expect = 1e-07
Identities = 40/148 (27%), Positives = 63/148 (42%), Gaps = 9/148 (6%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W+ W ECSVTCG+G++++ +C KG G V CD T+P Q++C + C
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCS-QRRCWSQDCVQHKG 1535
Query: 888 AGEWEA-CSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCN-RDILCP 945
CS +C +R +D Q + + +L S N R+ C
Sbjct: 1536 MERGRLNCSTSCERKDSHQR------MECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCN 1589
Query: 946 SDWTVGNWSECSVSCGGGVRIRSVTCAK 973
+ S+C+ +CG R R C +
Sbjct: 1590 YIVVTADSSQCANNCGFSYRQRITYCTE 1617
Score = 49.7 bits (117), Expect = 2e-05
Identities = 42/177 (23%), Positives = 61/177 (34%), Gaps = 22/177 (12%)
Query: 836 CSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACS 895
CS +C Q C V + T + K C C + C+
Sbjct: 1543 CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTI-SLTSKNCRNPPCNYIVVTADSSQCA 1601
Query: 896 ATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKP-----------KTLLSCNRDILC 944
CG ++R C + + + L H L+P + C L
Sbjct: 1602 NNCG-FSYRQRITYCTEIPSTKKHKL------HRLRPIVYQECPVVPSSQVYQCINSCLH 1654
Query: 945 PSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVT---RKPNSRALCGLQQCPS 998
+ W VG WS+CSV+CG G+ R V C H D+ KP ++ C C S
Sbjct: 1655 LATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDCKS 1711
Score = 48.9 bits (115), Expect = 4e-05
Identities = 23/54 (42%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQ--MDSD-CAAIQRPDPAKRCHLRPC 1365
A W VG WS+CS TCG+G R+V+C T+ + SD C +P K+C+ C
Sbjct: 1656 ATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/55 (40%), Positives = 31/55 (56%), Gaps = 3/55 (5%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKAC 882
W+ G W++CSVTCG GI ++ CI K + + C +P G QKKC+ C
Sbjct: 1658 WKVGKWSKCSVTCGIGIMKRQVKCITKHG--LSSDLCLNHLKP-GAQKKCYANDC 1709
Score = 42.4 bits (98), Expect = 0.004
Identities = 34/142 (23%), Positives = 57/142 (40%), Gaps = 27/142 (19%)
Query: 1267 NHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECS 1326
+H ++ NQ + ++ SL ++ NY +T + S+C+
Sbjct: 1552 SHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT----------ADSSQCA 1601
Query: 1327 TTCGLGAYWRRVECSTQMDSDCAAIQ---RPDPAKRCHLRPC-------------AGWKV 1370
CG +Y +R+ T++ S RP + C + P A WKV
Sbjct: 1602 NNCGF-SYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKV 1660
Query: 1371 GNWSKCSRNCSGGFKIREIQCV 1392
G WSKCS C G R+++C+
Sbjct: 1661 GKWSKCSVTCGIGIMKRQVKCI 1682
Score = 37.7 bits (86), Expect = 0.089
Identities = 24/78 (30%), Positives = 32/78 (41%), Gaps = 7/78 (8%)
Query: 500 WCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESI---PGGWGRWS--PWSHC 554
W S C L A C ++ A C K PE PG +W+ W C
Sbjct: 1313 WGSCSSSCSGGLQHRA--VVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGEC 1370
Query: 555 SRTCGAGVQSAERLCNNP 572
S+TCG G++S +C P
Sbjct: 1371 SQTCGGGIKSRLVICQFP 1388
Score = 36.2 bits (82), Expect = 0.26
Identities = 24/79 (30%), Positives = 30/79 (37%), Gaps = 9/79 (11%)
Query: 507 CRSKLDAAADGTQCGE-KKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSA 565
CR LD AD + C + C T P G + WS CS +CG G +
Sbjct: 1179 CRDALDRIADESYCAHLPRPAEIWDCFT--------PCGEWQAGDWSPCSASCGHGKTTR 1230
Query: 566 ERLCNNPEPKFGGKYCTGE 584
+ LC N YC E
Sbjct: 1231 QVLCMNYHQPIDENYCDPE 1249
Score = 35.0 bits (79), Expect = 0.58
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 23/93 (24%)
Query: 1447 GVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWD---LCSTSCGGGFQKRTVQCVPSEG 1503
G+ C GLC + T T N W G W+ CS +CGGG + T +C
Sbjct: 537 GMHCRHGLC--VNKETETRPVNGE----W--GPWEPYSSCSRTCGGGIESATRRC----- 583
Query: 1504 NKTEDQ---DQCLCDHKPRPPEFKKCNQQACKK 1533
N+ E + + C+ R +F+ CN +C K
Sbjct: 584 NRPEPRNGGNYCV----GRRMKFRSCNTDSCPK 612
Score = 34.3 bits (77), Expect = 0.99
Identities = 19/59 (32%), Positives = 24/59 (40%), Gaps = 3/59 (5%)
Query: 540 SIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRL--CNVHPC 596
S+ G R PW CS +C G+Q +C + E YC K L C PC
Sbjct: 1302 SVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQD-ENGQSASYCDAASKPPELQQCGPGPC 1359
Score = 32.3 bits (72), Expect = 3.8
Identities = 16/52 (30%), Positives = 20/52 (38%), Gaps = 2/52 (3%)
Query: 549 SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRL--CNVHPCRS 598
S WS C TCG G + + C +C K L C +H C S
Sbjct: 1028 SEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCAS 1079
Score = 32.0 bits (71), Expect = 4.9
Identities = 18/50 (36%), Positives = 22/50 (44%), Gaps = 9/50 (18%)
Query: 1430 EPWSQCSRSCGGGVQERGVFC-------PGGLCDWTKRPTSTMSCNEHLC 1472
EP+S CSR+CGGG++ C G C R SCN C
Sbjct: 563 EPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC--VGRRMKFRSCNTDSC 610
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 527 bits (1357), Expect = e-149
Identities = 324/928 (34%), Positives = 460/928 (49%), Gaps = 86/928 (9%)
Query: 100 KDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVL-QQGTRVGTAALS 158
+DL+ L + FLS + +E+ + A LC SG VL G+ V +A
Sbjct: 90 RDLYLQLRRDLRFLSRGFEVEEA----GAARRRGRPAELCFYSGRVLGHPGSLVSLSACG 145
Query: 159 ACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYRRQKVPETKEPTCGLKDSVNISQ 218
A GL G QL I+P+ G H++ R+ + T P+ + + +
Sbjct: 146 AAGGLVGLIQLGQEQVLIQPLNNSQGPFSG-REHLIRRKWSL--TPSPSAEAQRPEQLCK 202
Query: 219 K-QELWREKWERHNLPSRSLSRRS----ISKERWVETLVVADTKMIEYHGSENVESYILT 273
E + W R PSR R ++ E VETLVVAD M++YHG+E + +ILT
Sbjct: 203 VLTEKKKPTWGR---PSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILT 259
Query: 274 IMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSIN---- 329
+MNMV +F + S+G I+I V +L+LL + L I HH E++L SFC WQ
Sbjct: 260 VMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGAR 319
Query: 330 -------PKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDS 382
P +P D AV +TR D C + PC+T+G+++L G+C R C + ED+
Sbjct: 320 YLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDN 379
Query: 383 GLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQY--DPTPLTWSKCSEEYI 440
GL LAFTIAHELGH+ G+ HD + C GR +IMS + +P+ L+WS CS + +
Sbjct: 380 GLNLAFTIAHELGHNLGMNHDDDHSSC--AGRS-HIMSGEWVKGRNPSDLSWSSCSRDDL 436
Query: 441 TRFLDRGWGFCL--DDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENV-CQ 497
FL CL D + ++ PG+ Y + QCQ+ +G NATFC+ +E++ C
Sbjct: 437 ENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCA 496
Query: 498 TLWCSVKG--FCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCS 555
LWC V+G C++KLD DGT+CG KWC AG+C++ PE + G W W WS CS
Sbjct: 497 GLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCS 556
Query: 556 RTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTV- 614
RTCG G + +R C+NP P GG +C G + +C PC P+FR QC D +
Sbjct: 557 RTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLS 616
Query: 615 PYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICK 674
P K L + PCELYC P+ + + D V+DGTPC G ++C++G C+
Sbjct: 617 PKKKGLL--TAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPC--GPYETDLCVHGKCQ 672
Query: 675 MVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEI 734
+GCD I S A EDRCGVC GDG +C V+ F G+ D G KG+
Sbjct: 673 KIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSG---KGS-------- 721
Query: 735 EGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVW 794
+N + I+ G +++AGT +Y R+G EK+ A GPT +
Sbjct: 722 ------------------INSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLH 763
Query: 795 IQ-LLFQVTNPGIKYEYTI------QKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQ 847
+ LLF + GI YEYT+ + + ++ W + W CSV CG G RR
Sbjct: 764 LMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRT 823
Query: 848 TAHC---IKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEK 904
C + K +V + C ++P + ++C+ C RW AG W CSATC G +
Sbjct: 824 IVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATC-EKGFQ 882
Query: 905 KRTVLCI-QTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGG 963
R V C+ Q A P C +P + SC C S W WS+CS SCG G
Sbjct: 883 HREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQSCEGQD-CLSIWEASEWSQCSASCGKG 940
Query: 964 VRIRSVTCAKNHDEPCDVTRKPNSRALC 991
V R+V C N CD + +P + C
Sbjct: 941 VWKRTVACT-NSQGKCDASTRPRAEEAC 967
Score = 160 bits (405), Expect = 9e-39
Identities = 92/285 (32%), Positives = 130/285 (45%), Gaps = 38/285 (13%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM--------DSDCAAIQRPDP-AKRCHLRPCAG 1367
W W CS CG G V C+ + DSDC RP+P +RC+L PC
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
Query: 1368 -WKVGNWSKCSRNCSGGFKIREIQCV---DSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
W G WS CS C GF+ RE+ CV + H RP +C G P SC +
Sbjct: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCP---GPRPAAVQSCEGQD 920
Query: 1424 C-EAWQVEPWSQCSRSCGGGVQERGVFCPG--GLCDWTKRPTSTMSCNEHLCCH-WATGN 1479
C W+ WSQCS SCG GV +R V C G CD + RP + +C ++ C+ W TG+
Sbjct: 921 CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSGCYEWKTGD 980
Query: 1480 WDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK------- 1532
W CS++CG G Q R VQC+ +K + C +P +++C Q+ C
Sbjct: 981 WSTCSSTCGKGLQSRVVQCM----HKVTGRHGSECPALSKPAPYRQCYQEVCNDRINANT 1036
Query: 1533 ------KSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
+ CT+D+ + +C+ ++ C CC +C
Sbjct: 1037 ITSPRLAALTYKCTRDQWTV-YCRVIREKNLCQDMRWYQRCCQTC 1080
Score = 80.1 bits (196), Expect = 2e-14
Identities = 50/175 (28%), Positives = 70/175 (40%), Gaps = 26/175 (14%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQR------PDPA--KRCHLRPCA 1366
+ W+ G WS CS TC G R V C Q+ + R P PA + C + C
Sbjct: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL 922
Query: 1367 G-WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNP-EPC 1424
W+ WS+CS +C G R + C +S+ + A P +C C
Sbjct: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQGKCD---------ASTRPRAEEACEDYSGC 973
Query: 1425 EAWQVEPWSQCSRSCGGGVQERGVFC-------PGGLCDWTKRPTSTMSCNEHLC 1472
W+ WS CS +CG G+Q R V C G C +P C + +C
Sbjct: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 49.3 bits (116), Expect = 3e-05
Identities = 21/57 (36%), Positives = 32/57 (56%), Gaps = 4/57 (7%)
Query: 1313 GSAHWIVGNWSECSTTCGLGAYWRRVECSTQM----DSDCAAIQRPDPAKRCHLRPC 1365
G W G+WS CS+TCG G R V+C ++ S+C A+ +P P ++C+ C
Sbjct: 972 GCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 41.2 bits (95), Expect = 0.008
Identities = 18/60 (30%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Query: 826 YFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPR 885
Y W+ G W+ CS TCG G++ + C+ K G + C ++P ++C+++ C R
Sbjct: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR-HGSECPALSKP-APYRQCYQEVCNDR 1031
Score = 34.3 bits (77), Expect = 0.99
Identities = 50/201 (24%), Positives = 72/201 (35%), Gaps = 36/201 (17%)
Query: 1372 NWSKCSRNCSGGF-KIREIQCV---DSRDHRNLRPFH------------CQFLAGIPPPL 1415
+WS CSR+ F K + C+ D R +R H CQ L G+
Sbjct: 427 SWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATF 486
Query: 1416 SMSCNPEPCEA-W-QVEPWSQCSRSCGGGVQ--ERGV--FCPGGLCDWTKRPTSTMSCNE 1469
+ C W VE + C + E G +C G C S E
Sbjct: 487 CRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGEC------VSKTPIPE 540
Query: 1470 HLCCHWAT-GNWDLCSTSCGGGFQKRTVQC---VPSEGN---KTEDQDQCLCDHKPRPPE 1522
H+ W+ G W +CS +CG G + R +C P G + +C++ P P
Sbjct: 541 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG 600
Query: 1523 FKKCNQQACKKSADLLCTKDK 1543
Q C ++ D L K K
Sbjct: 601 LPSFRDQQC-QAHDRLSPKKK 620
Score = 31.6 bits (70), Expect = 6.4
Identities = 12/21 (57%), Positives = 15/21 (71%)
Query: 1320 GNWSECSTTCGLGAYWRRVEC 1340
G WS CS TCG GA +R+ +C
Sbjct: 550 GAWSMCSRTCGTGARFRQRKC 570
Score = 31.2 bits (69), Expect = 8.4
Identities = 18/48 (37%), Positives = 20/48 (41%), Gaps = 2/48 (4%)
Query: 551 WSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERK--RYRLCNVHPC 596
WS CS TCG G+QS C + G C K YR C C
Sbjct: 981 WSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 484 bits (1246), Expect = e-136
Identities = 313/999 (31%), Positives = 486/999 (48%), Gaps = 67/999 (6%)
Query: 46 IKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFN 105
IK EY +V PV + G +LS+ L R RD+ + + +++ I+ KD
Sbjct: 36 IKRYREYELVTPVSTNLEGRYLSHTLSAS-HKKRSARDVSSNPEQLFFNITAFGKDFHLR 94
Query: 106 LTVNQGFLSNSYIMEKRYGNL---------------SHVKMMASSAPL---CHLSGTVLQ 147
L N ++ ++E +L S + + PL C G ++
Sbjct: 95 LKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVD 154
Query: 148 -QGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKK-HPLVEGGYHPHIVYRRQKVPETKE 205
GT V A+S C GL G + + ++FIEP+++ + E H+VY+R V +
Sbjct: 155 IPGTSV---AISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQA-- 209
Query: 206 PTCGLKD----SVNISQKQELWREKWERHNLPSRSLSRRSISKERW--VETLVVADTKMI 259
P KD ++ +L H + ++ RR + E +E L+ D ++
Sbjct: 210 PIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVV 269
Query: 260 EYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVH-HAEKTL 318
+HG E+V++Y+LT+MN+V ++H+ S+G I++V+VR+I+L + I + ++L
Sbjct: 270 RFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSL 329
Query: 319 SSFCKWQKSINPKSDLN-PVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCN 377
+ C+W S +SDLN HHD A+ LTR+D P G + ++GMC P RSC
Sbjct: 330 ENVCRWA-SQQQRSDLNHSEHHDHAIFLTRQDF-----GPAGMQGYAPVTGMCHPVRSCT 383
Query: 378 INEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSE 437
+N + G AF +AHE GH G++HDG+ N C +M+ +Q WS+CS
Sbjct: 384 LNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSG 443
Query: 438 EYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENV-- 495
+ + R++ CL D P PG+ Y + QC+ +G C
Sbjct: 444 QELKRYIHSY--DCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDP 501
Query: 496 CQTLWCSVKG---FCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWS 552
C+ LWCS FC++K DGT+C KWC G C+ + G WG W+ +
Sbjct: 502 CKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFG 561
Query: 553 HCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFD 612
CSRTCG GV+ R CNNP P GG+ C G Y+LCN C+ FR QC + +
Sbjct: 562 SCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRN 621
Query: 613 T-VPYKNELYHWFPIF--NPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCI 669
+ Y+N +HW P +P C LYC+ + M V DGT C + ++C+
Sbjct: 622 SHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHC-SYKDPYSICV 680
Query: 670 NGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMF-KQKEGSGYVDIGLIPKGARD 728
G C VGCD EI SN ED+CGVC GD S C+TV+ F + GY+ + IP GAR
Sbjct: 681 RGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARH 740
Query: 729 IRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGP 788
+ + E E + + LAI+++ Y LNG + + G + Y+ + D+E L GP
Sbjct: 741 VLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGP 800
Query: 789 TNESVWIQLLFQV--TNPGIKYEYTIQKDGL-----DNDVEQQM--YFWQYGHWTECSVT 839
++ V + ++ Q T + Y+Y I +D + +N +++++ + W W++CS
Sbjct: 801 LHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKP 860
Query: 840 CGTGIRRQTAHCIKKG-RGMVKATFCDPETQPNGRQKKCHEKACP-PRWWAGEWEACSAT 897
CG G + C +K MV +FC+ +P ++ C+ + C P W A EWE C+ T
Sbjct: 861 CGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKT 920
Query: 898 CGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECS 957
CG G + RTV C+Q ++ + +P++ CNR + CP+ W G WSECS
Sbjct: 921 CGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNR-VPCPAQWKTGPWSECS 979
Query: 958 VSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQC 996
V+CG G +R V C + CD KP S C L C
Sbjct: 980 VTCGEGTEVRQVLCRAG--DHCD-GEKPESVRACQLPPC 1015
Score = 103 bits (258), Expect = 1e-21
Identities = 69/225 (30%), Positives = 94/225 (41%), Gaps = 32/225 (14%)
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE-- 1425
W + +WS+CS+ C GGF+ + C D++ + C+ P P+ CN + C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKK-PKPIRRMCNIQECTHP 907
Query: 1426 AWQVEPWSQCSRSCGG-GVQERGVFCPGGLCDWTKR-----------PTSTMSCNEHLC- 1472
W E W C+++CG G Q R V C L D T R P S CN C
Sbjct: 908 LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCP 967
Query: 1473 CHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK 1532
W TG W CS +CG G + R V C + CD + +P + C C
Sbjct: 968 AQWKTGPWSECSVTCGEGTEVRQVLCRAGDH----------CDGE-KPESVRACQLPPCN 1016
Query: 1533 KSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTHIT 1577
D C DK + FCQ + CS+P CC SC + T
Sbjct: 1017 ---DEPCLGDK--SIFCQMEVLARYCSIPGYNKLCCESCSKRSST 1056
Score = 101 bits (252), Expect = 5e-21
Identities = 59/204 (28%), Positives = 96/204 (47%), Gaps = 19/204 (9%)
Query: 1287 EEDATSLITEGFLLNASNYKQLTNGH------GSAHWIVGNWSECSTTCGLGAYWRRVEC 1340
E D S +T ++++ + + + + + W + +WS+CS CG G + + C
Sbjct: 813 ENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGC 872
Query: 1341 STQMD------SDCAAIQRPDPAKR-CHLRPCAG--WKVGNWSKCSRNC-SGGFKIREIQ 1390
+ D S C A ++P P +R C+++ C W W C++ C S G+++R ++
Sbjct: 873 RRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVR 932
Query: 1391 CVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA-WQVEPWSQCSRSCGGGVQERGVF 1449
C+ R H ++ G P CN PC A W+ PWS+CS +CG G + R V
Sbjct: 933 CLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVL 992
Query: 1450 C-PGGLCDWTKRPTSTMSCNEHLC 1472
C G CD K P S +C C
Sbjct: 993 CRAGDHCDGEK-PESVRACQLPPC 1015
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 468 bits (1205), Expect = e-131
Identities = 304/901 (33%), Positives = 449/901 (49%), Gaps = 83/901 (9%)
Query: 94 RISHEEKDLFFNLTVNQGFLSNSYIME---KRYGNLSHVKMMASSAPLCHLSGTVLQQGT 150
R+ ++ L L + FL+ + ++ ++ G S + + C SGTV G
Sbjct: 77 RLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSG--SETPLPETDLAHCFYSGTV--NGD 132
Query: 151 RVGTAALSACHGLTGFFQLPHGDFFIEPV----KKHPLVEGGYHP------HIVYRRQKV 200
AALS C G+ G F L +FI+P+ ++ G P H++ R ++
Sbjct: 133 PSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQ- 191
Query: 201 PETKEPTCGL-KDSVNISQKQELWRE-----------KWERHNLPSRSLS---------- 238
TCG+ D + K E E +W + + +
Sbjct: 192 -GDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRK 250
Query: 239 RRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRL 298
+R +S R+VET++VAD M E+HGS ++ Y+LT+ ++ L+ +PSI N++ +VVV++
Sbjct: 251 KRFVSSHRYVETMLVADQSMAEFHGS-GLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKI 309
Query: 299 ILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPC 358
+++ +E++G ++ +A TL +FC WQK NP SD + H+D A+L TR+D+C ++ C
Sbjct: 310 LVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCG--SQTC 367
Query: 359 ETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKEN--DCEPVGRHP 416
+TLG++ + +C P RSC++ ED GL AFT AHELGH F + HD + V +
Sbjct: 368 DTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDS 427
Query: 417 YIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHH 476
++M+ L WS CS IT FLD G G CL D P+ ++ PG YD +
Sbjct: 428 HMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNP-IQLPGDLPGTSYDANR 486
Query: 477 QCQLQYGPNATFCQEVENVCQTLWCSVKG----FCRSKLDAAADGTQCGEKKWCMAGKCI 532
QCQ +G ++ C + + C TLWC+ C++K ADGT CGE KWC+ GKC+
Sbjct: 487 QCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCV 546
Query: 533 T-VGKKPESIP--GGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYR 589
+K P G WG W PW CSRTCG GVQ R C+NP PK GGKYC G+R RYR
Sbjct: 547 NKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYR 606
Query: 590 LCNVHPC-RSEAPTFRQMQC---SEFDTVPY-KNELYHWFPIF---NPAHPCELYCRPID 641
CN+ C + TFR+ QC +EF + W P + +P C+L C+
Sbjct: 607 SCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKG 666
Query: 642 GQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSC 701
+ + V+DGTPC +S +VC+ G C GCD IDS D+CGVC G+GS+C
Sbjct: 667 IGYFFVLQPKVVDGTPC--SPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTC 724
Query: 702 QTVRKMFKQKEGSGYVDIGLIPKGARDIRVME-----IEGAGNFLAIRSEDPEKYYLNGG 756
+ + + GY DI IP GA +I V + G+FLAI++ D Y LNG
Sbjct: 725 KKISGSVTSAK-PGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD-GTYILNGD 782
Query: 757 FIIQ-WNGNYKLAGTVFQYD-RKGDLEKLMATGPTNESVWIQLLF--QVTNPGIKYEYTI 812
+ + + G V +Y LE++ + P E + IQ+L P IKY Y +
Sbjct: 783 YTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFV 842
Query: 813 QKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNG 872
+K + W W ECS +C G +R+ C + A+ C E +P
Sbjct: 843 KKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC--RDINGQPASECAKEVKP-A 899
Query: 873 RQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKP 932
+ C + C P+W GEW +CS TCG G KKR++ C+ D L C L KP
Sbjct: 900 STRPCADHPC-PQWQLGEWSSCSKTCG-KGYKKRSLKCLS---HDGGVLSHESCDPLKKP 954
Query: 933 K 933
K
Sbjct: 955 K 955
Score = 79.7 bits (195), Expect = 2e-14
Identities = 37/104 (35%), Positives = 52/104 (50%), Gaps = 9/104 (8%)
Query: 1426 AWQVEPWSQCSRSCGGGVQERGVFC------PGGLCDWTKRPTSTMSCNEHLCCHWATGN 1479
AW +E W +CS+SC G Q R V C P C +P ST C +H C W G
Sbjct: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGE 916
Query: 1480 WDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEF 1523
W CS +CG G++KR+++C+ +G + CD +P F
Sbjct: 917 WSSCSKTCGKGYKKRSLKCLSHDGGVLSHES---CDPLKKPKHF 957
Score = 74.3 bits (181), Expect = 9e-13
Identities = 31/79 (39%), Positives = 45/79 (56%), Gaps = 3/79 (3%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVEC---STQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNW 1373
W++ W ECS +C LG R VEC + Q S+CA +P + C PC W++G W
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEW 917
Query: 1374 SKCSRNCSGGFKIREIQCV 1392
S CS+ C G+K R ++C+
Sbjct: 918 SSCSKTCGKGYKKRSLKCL 936
Score = 63.2 bits (152), Expect = 2e-09
Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 1366 AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE 1425
+ W + W +CS++C G++ R ++C RD C + P + C PC
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECA--KEVKPASTRPCADHPCP 910
Query: 1426 AWQVEPWSQCSRSCGGGVQERGVFC---PGGL-----CDWTKRP 1461
WQ+ WS CS++CG G ++R + C GG+ CD K+P
Sbjct: 911 QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 37.0 bits (84), Expect = 0.15
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 946 SDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEP---CDVTRKPNSRALCGLQQCP 997
S W + W ECS SC G + R V C + +P C KP S C CP
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCP 910
Score = 36.6 bits (83), Expect = 0.20
Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%)
Query: 1312 HGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKR 1359
H W +G WS CS TCG G R ++C + D + + DP K+
Sbjct: 907 HPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSH-DGGVLSHESCDPLKK 953
Score = 35.0 bits (79), Expect = 0.58
Identities = 16/57 (28%), Positives = 23/57 (40%), Gaps = 5/57 (8%)
Query: 1475 WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W W CS SC G+Q+R V+C G + C + +P + C C
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASE-----CAKEVKPASTRPCADHPC 909
Score = 33.9 bits (76), Expect = 1.3
Identities = 28/102 (27%), Positives = 37/102 (36%), Gaps = 32/102 (31%)
Query: 1354 PDPAKRCHLRPCAGWKVG---------NWSKCSRNCSGGFKIREIQCVDSRDHRNL-RPF 1403
PD A C C G G W+ +C G +CV+ D ++ PF
Sbjct: 500 PDAASTCSTLWCTGTSGGVLVCQTKHFPWAD-GTSCGEGKWCINGKCVNKTDRKHFDTPF 558
Query: 1404 HCQFLAGIPPPLSMSCNPEPCEAWQV-EPWSQCSRSCGGGVQ 1444
H +W + PW CSR+CGGGVQ
Sbjct: 559 H--------------------GSWGMWGPWGDCSRTCGGGVQ 580
Score = 33.9 bits (76), Expect = 1.3
Identities = 30/105 (28%), Positives = 39/105 (37%), Gaps = 22/105 (20%)
Query: 1431 PWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWAT-GNWDLCSTSCGG 1489
PW+ SCG G +C G C T + W G W CS +CGG
Sbjct: 527 PWAD-GTSCG-----EGKWCINGKC---VNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGG 577
Query: 1490 GFQKRTVQC---VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
G Q +C VP G K C+ K ++ CN + C
Sbjct: 578 GVQYTMRECDNPVPKNGGK-------YCEGK--RVRYRSCNLEDC 613
Score = 33.5 bits (75), Expect = 1.7
Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 6/53 (11%)
Query: 951 GNWSECSVSCGGGVRIRSVTC----AKNHDEPCDVTRKPNSRALCGLQQCPSS 999
G W +CS +CGGGV+ C KN + C+ R C L+ CP +
Sbjct: 566 GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRV--RYRSCNLEDCPDN 616
Score = 32.0 bits (71), Expect = 4.9
Identities = 30/97 (30%), Positives = 39/97 (40%), Gaps = 15/97 (15%)
Query: 1297 GFLLNASNYKQL-TNGHGSAHW-IVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRP 1354
G +N ++ K T HGS W + G W +CS TCG G + EC + + +
Sbjct: 543 GKCVNKTDRKHFDTPFHGS--WGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGG---KY 597
Query: 1355 DPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQC 1391
KR R C N C N G RE QC
Sbjct: 598 CEGKRVRYRSC------NLEDCPDN--NGKTFREEQC 626
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 459 bits (1180), Expect = e-128
Identities = 306/1000 (30%), Positives = 483/1000 (48%), Gaps = 72/1000 (7%)
Query: 57 PVRVDASGHFLSY---------GLHYPITSSRRKRDLDGSED-----WVYYRISHEEKDL 102
PVR DA G +S+ G+ + R G + ++Y ++ +DL
Sbjct: 61 PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
Query: 103 FFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTA-----AL 157
L N ++ ME + G ++ L G+ L G G A AL
Sbjct: 121 HLRLRPNARLVAPGATMEWQ-GEKGTTRVEP-------LLGSCLYVGDVAGLAEASSVAL 172
Query: 158 SACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHP--HIVYRRQKVPETKEPTCG---LKD 212
S C GL G ++ +FFIEP++K + H+VYRR P T P G L
Sbjct: 173 SNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR---PPTSPPLGGPQALDT 229
Query: 213 SVNISQKQELWREKW--ERHNLPSRSLSRRSISKERW-VETLVVADTKMIEYHGSENVES 269
++ L R E H SR +RR + + + +E L+ D ++++HG E+V+
Sbjct: 230 GASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQK 289
Query: 270 YILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEE-EEQGLKIVHHAEKTLSSFCKWQKSI 328
Y+LT+MN+V ++H+ S+G I++V+VR+ILL + L + + ++L + C+W
Sbjct: 290 YLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQ 349
Query: 329 NPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAF 388
+ +HD A+ LTR+D P G + ++GMC P RSC +N + G AF
Sbjct: 350 QKPDTGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAF 404
Query: 389 TIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGW 448
+AHE GH G++HDG+ N C R IM+ +Q WS+CS++ ++R+L
Sbjct: 405 VVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSY- 463
Query: 449 GFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENV--CQTLWCSVKG- 505
CL D P + PG+ Y ++ QC+ +G C C+ LWCS
Sbjct: 464 -DCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDN 522
Query: 506 --FCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQ 563
FC++K DGT C K C G CI + G WG WSP+ CSRTCG GV+
Sbjct: 523 PYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVK 582
Query: 564 SAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDT-VPYKNELYH 622
R C+NP P GG+ C+G ++LC+ C FR+ QC ++D + + +H
Sbjct: 583 FRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHH 642
Query: 623 WFP--IFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDY 680
W P + C LYC + M V DGT C ++ ++C+ G C+ VGCD
Sbjct: 643 WLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRC-SYKDAFSLCVRGDCRKVGCDG 701
Query: 681 EIDSNATEDRCGVCLGDGSSCQTVRKMF-KQKEGSGYVDIGLIPKGARDIRVMEIEGAGN 739
I S+ ED+CGVC GD S C+ V+ F + + GY+ + IP GAR + + E++ +
Sbjct: 702 VIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSH 761
Query: 740 FLAIRSEDPEKYYLNGGFIIQWNGNYKLA-GTVFQYDRKGDLEKLMATGPTNESVWIQLL 798
LA+++ + K+ LN + + +A G ++Y + E L GP + ++ + ++
Sbjct: 762 HLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVI 821
Query: 799 -FQVTNPGIKYEYTIQKDGL---DNDVEQQ---MYFWQYGHWTECSVTCGTGIRRQTAHC 851
T + Y+Y I +D L DN+V ++ +Y W W+ CS CG G + C
Sbjct: 822 PVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGC 881
Query: 852 IKK-GRGMVKATFCDPETQPNGRQKKCHEKAC-PPRWWAGEWEACSATCGPHGEKKRTVL 909
++ MV FC ++P ++ C+ + C P W GEWE CS TCG G + R+V
Sbjct: 882 RRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVR 941
Query: 910 CIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSV 969
CIQ + + + +P++ +C+R+ LCP W G WS+CSV+CG G + R V
Sbjct: 942 CIQPLHDNTTRSVHAKHCNDARPESRRACSRE-LCPGRWRAGPWSQCSVTCGNGTQERPV 1000
Query: 970 TCAKNHDEPCDVTR--KPNSRALCGLQQCPSSRRVLKPNK 1007
C + D+ + + +P + C L CP R + P+K
Sbjct: 1001 LC-RTADDSFGICQEERPETARTCRLGPCP--RNISDPSK 1037
Score = 103 bits (258), Expect = 1e-21
Identities = 75/288 (26%), Positives = 113/288 (39%), Gaps = 51/288 (17%)
Query: 1300 LNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQR 1353
LN + L W + WS CS CG G+ + + C ++D CAA+ +
Sbjct: 841 LNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSK 900
Query: 1354 PDPAKR-CHLRPCAG--WKVGNWSKCSRNCSG-GFKIREIQCVDSRDHRNLRPFHCQFLA 1409
P +R C+ + C+ W G W CS+ C G ++R ++C+ R H +
Sbjct: 901 PKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN 960
Query: 1410 GIPPPLSMSCNPEPCEA-WQVEPWSQCSRSCGGGVQERGVFC-----PGGLCDWTKRPTS 1463
P +C+ E C W+ PWSQCS +CG G QER V C G+C +RP +
Sbjct: 961 DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQ-EERPET 1019
Query: 1464 TMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEF 1523
+C C R + S+ +K Q L P P
Sbjct: 1020 ARTCRLGPC--------------------PRNI----SDPSKKSYVVQWLSRPDPDSPIR 1055
Query: 1524 KKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
K ++ C+ + C + LS + CS+P CC SC
Sbjct: 1056 KISSKGHCQGDKSIFCRMEVLS----------RYCSIPGYNKLCCKSC 1093
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 456 bits (1174), Expect = e-128
Identities = 320/989 (32%), Positives = 478/989 (48%), Gaps = 101/989 (10%)
Query: 50 PEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVN 109
PE VV P+R+D + Y P D + + ++I+ ++D + +LT +
Sbjct: 21 PEREVVVPIRLDPDINGRRYYWRGPE---------DSGDQGLIFQITAFQEDFYLHLTPD 71
Query: 110 QGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQL 169
FL+ ++ E L + +S C SG V + AA+S C GL G F
Sbjct: 72 AQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSF--AAVSLCGGLRGAFGY 129
Query: 170 PHGDFFIEPVKKH--PLVEGGYHPHIVYRRQKVP--ETKEPT--CGLKDSVNISQKQELW 223
++ I P+ P + + +R+ VP + +PT CG+ N + + L
Sbjct: 130 RGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALD 189
Query: 224 REKWERHNLPSRSLSRRS------ISKERWVETLVVADTKMIEYHGSENVESYILTIMNM 277
K R RRS +S R+VETLVVAD M+++HG++ +E Y+LT++
Sbjct: 190 PYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLAT 248
Query: 278 VTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPV 337
L+ +PSI N I+IVVV+++LL + + G K+ +A TL +FC WQK +N SD +P
Sbjct: 249 AARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPE 308
Query: 338 HHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHS 397
+ D A+L TR+D+C C+TLG++ + MC P RSC++ ED GLP AFT AHELGH
Sbjct: 309 YWDTAILFTRQDLCGATT--CDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHV 366
Query: 398 FGIQHDGKENDCEPVG--RHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDI 455
F + HD + E G R ++MS L WS CS IT FLD G G CL D
Sbjct: 367 FNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQ 426
Query: 456 PKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKG----FCRSKL 511
P K + PG Y + QC+L +G + C ++ C LWC+ K C+++
Sbjct: 427 PSKP-ISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQ-YCTKLWCTGKAKGQMVCQTRH 484
Query: 512 DAAADGTQCGEKKWCMAGKCITVGK-KPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCN 570
ADGT CGE K C+ G C+ + G W +W P+ CSRTCG GVQ A R C
Sbjct: 485 FPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCT 544
Query: 571 NPEPKFGGKYCTGERKRYRLCNVHPCRSEAP--TFRQMQCSEFDTVPYKNE----LYHWF 624
NP P GGKYC G R +YR CN+ PC S A +FR+ QC F+ + W
Sbjct: 545 NPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWV 604
Query: 625 PIFNPAHP---CELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYE 681
P ++ P C+L CR + + V+DGT C +S +VC+ G C GCD
Sbjct: 605 PKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLC--SPDSTSVCVQGKCIKAGCDGN 662
Query: 682 IDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVME-----IEG 736
+ S D+CGVC GD SC+ V +F K GY + IP GA I + + + G
Sbjct: 663 LGSKKRFDKCGVCGGDNKSCKKVTGLFT-KPMHGYNFVVAIPAGASSIDIRQRGYKGLIG 721
Query: 737 AGNFLAIRSEDPEKYYLNGGFIIQW-NGNYKLAGTVFQYDRKGD-LEKLMATGPTNESVW 794
N+LA+++ KY LNG F++ + + G++ +Y G +E L A+ P E +
Sbjct: 722 DDNYLALKNSQG-KYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLT 780
Query: 795 IQLLF--QVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCI 852
+++L ++T P ++Y + + K+ ++ G + +
Sbjct: 781 VEVLSVGKMTPPRVRYSFYLPKEPREDKSSHP------------KDPRGPSVLHNSV--- 825
Query: 853 KKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQ 912
+ + QP+ R P RW AG W CSA+CG G +KR V C
Sbjct: 826 --------LSLSNQVEQPDDRP--------PARWVAGSWGPCSASCGS-GLQKRAVDCRG 868
Query: 913 TMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCA 972
+ + ++ +P D H +P +C CP+ W + WS CS SCG G + RS+ C
Sbjct: 869 S--AGQRTVPACDAAH--RPVETQACGEP--CPT-WELSAWSPCSKSCGRGFQRRSLKCV 921
Query: 973 KNHD-----EPCDVTRKPNSRALCGLQQC 996
+ + C++ RKP C L+ C
Sbjct: 922 GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 82.4 bits (202), Expect = 3e-15
Identities = 42/108 (38%), Positives = 53/108 (49%), Gaps = 9/108 (8%)
Query: 1423 PCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL-------CDWTKRPTSTMSCNEHLCCHW 1475
P W W CS SCG G+Q+R V C G CD RP T +C E C W
Sbjct: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP-CPTW 897
Query: 1476 ATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEF 1523
W CS SCG GFQ+R+++CV G + +DQC KP+ +F
Sbjct: 898 ELSAWSPCSKSCGRGFQRRSLKCV-GHGGRLLARDQCNLHRKPQELDF 944
Score = 76.3 bits (186), Expect = 2e-13
Identities = 43/140 (30%), Positives = 65/140 (46%), Gaps = 14/140 (10%)
Query: 1271 LPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCG 1330
LP + KSS P ++ + +L+ SN + + A W+ G+W CS +CG
Sbjct: 800 LPKEPREDKSSHP---KDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCG 856
Query: 1331 LGAYWRRVEC----STQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKI 1386
G R V+C + C A RP + C PC W++ WS CS++C GF+
Sbjct: 857 SGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPTWELSAWSPCSKSCGRGFQR 915
Query: 1387 REIQCVD------SRDHRNL 1400
R ++CV +RD NL
Sbjct: 916 RSLKCVGHGGRLLARDQCNL 935
Score = 69.7 bits (169), Expect = 2e-11
Identities = 36/102 (35%), Positives = 50/102 (49%), Gaps = 11/102 (10%)
Query: 1351 IQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAG 1410
+++PD RP A W G+W CS +C G + R + C S R + C A
Sbjct: 832 VEQPDD------RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA--CD--AA 881
Query: 1411 IPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPG 1452
P + +C EPC W++ WS CS+SCG G Q R + C G
Sbjct: 882 HRPVETQACG-EPCPTWELSAWSPCSKSCGRGFQRRSLKCVG 922
Score = 49.7 bits (117), Expect = 2e-05
Identities = 23/54 (42%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 1475 WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQ 1528
W G+W CS SCG G QKR V C S G +T CD RP E + C +
Sbjct: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVP----ACDAAHRPVETQACGE 892
Score = 46.6 bits (109), Expect = 2e-04
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 5/58 (8%)
Query: 945 PSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE----PCDVTRKPNSRALCGLQQCPS 998
P+ W G+W CS SCG G++ R+V C + + CD +P CG + CP+
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPT 896
Score = 32.7 bits (73), Expect = 2.9
Identities = 33/112 (29%), Positives = 44/112 (39%), Gaps = 30/112 (26%)
Query: 1431 PWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEH-LCCHWATGNWDL---CSTS 1486
PW+ SCG G C G C + N+H + WA WD CS +
Sbjct: 486 PWAD-GTSCG-----EGKLCLKGAC------VERHNLNKHRVDGSWA--KWDPYGPCSRT 531
Query: 1487 CGGGFQKRTVQC---VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
CGGG Q QC P+ G K C+ +++ CN + C SA
Sbjct: 532 CGGGVQLARRQCTNPTPANGGK-------YCEGV--RVKYRSCNLEPCPSSA 574
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 437 bits (1125), Expect = e-122
Identities = 308/1025 (30%), Positives = 473/1025 (46%), Gaps = 102/1025 (9%)
Query: 44 HFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLD------------------ 85
H L +Y V P D G FLS+ + P +S +D
Sbjct: 30 HLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSP 89
Query: 86 ---GSEDW--------VYYRISHEEKDLFFNLTVNQGFL--SNSYIMEKRYGNLSHVKMM 132
G W +Y+ ++ K+L L N+ + +S ++ + L +
Sbjct: 90 LHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLR 149
Query: 133 ASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKK-HPLVEGGYHP 191
C +G V G A+S C GL G + DFFIEP+++ E
Sbjct: 150 QE----CVYTGGVT--GMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRT 203
Query: 192 HIVYRRQKVP-ETKEP-------TCGLKDSVNISQK--QELWREKWERHNLPSRSLSRRS 241
H+VYRR+ V E EP GL D N+ +L + +R + S S
Sbjct: 204 HVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYS--- 260
Query: 242 ISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILL 301
+E L+V D ++ +HG E+V++Y+LT+MN+V ++H+ S+G I+I +VRLI++
Sbjct: 261 ------IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMV 314
Query: 302 EEEEQGLKIVHHAE--KTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCE 359
Q L ++ ++L C+W S + + HHD V LTR+D P
Sbjct: 315 GYR-QSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF-----GPSG 368
Query: 360 TLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIM 419
G + ++GMC P RSC +N + G AF IAHE GH G++HDG+ N C +M
Sbjct: 369 MQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 428
Query: 420 SRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQ 479
+ +Q WS+CS+ ++R+L CL D P PG+ Y + QC+
Sbjct: 429 APLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCR 486
Query: 480 LQYGPNATFCQEVENV--CQTLWCSVKG---FCRSKLDAAADGTQCGEKKWCMAGKCITV 534
+G C C+ LWCS FC++K DGT+C KWC G CI
Sbjct: 487 FDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW- 545
Query: 535 GKKPESI---PGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLC 591
K PE GGW W+ + CSR+CG GV+S R CNNP P +GG+ C G Y++C
Sbjct: 546 -KSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVC 604
Query: 592 NVHPCRSEAPTFRQMQCSEFDT-VPYKNELYHWFPIFNP---AHPCELYCRPIDGQFSEK 647
N C FR QC++ ++ ++N + W P + P A CEL C+ D
Sbjct: 605 NSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVP-YEPDDDAQKCELICQSADTGDVVF 663
Query: 648 MLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVR-K 706
M V DGT C + +VC G C VGCD E+ S +D+CGVC GD S C+TV+
Sbjct: 664 MNQVVHDGTRC-SYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGT 722
Query: 707 MFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYK 766
+ K + +G + + IP GAR I++ +E + + + ++++ + LN + +
Sbjct: 723 LGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFT 782
Query: 767 LAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPG----IKYEYTIQKDGL----D 818
G ++ + E L +GP E++ I L T G + Y+Y I +D L
Sbjct: 783 AMGLEWEDAVEDAKESLKTSGPLPEAIAI-LALPPTEGGPRSSLAYKYVIHEDLLPLIGS 841
Query: 819 NDV---EQQMYFWQYGHWTECSVTCGTGIRRQTAHC-IKKGRGMVKATFCDPETQPNGRQ 874
N+V E Y W W CS CG GI+ C ++ MV+ CD + +P +
Sbjct: 842 NNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIR 901
Query: 875 KKCHEKAC-PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPK 933
++C++ C P W EW ACS +CG G + R + C+ + + + P +P+
Sbjct: 902 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 961
Query: 934 TLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE--PCDVTRKPNSRALC 991
C R + CP+ W +G WS+CS +CG G++ R V C N + C+ R P++ +C
Sbjct: 962 ARRPCLR-VPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDR-PDTVQVC 1019
Query: 992 GLQQC 996
L C
Sbjct: 1020 SLPAC 1024
Score = 101 bits (251), Expect = 7e-21
Identities = 79/271 (29%), Positives = 111/271 (40%), Gaps = 44/271 (16%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPAKR-CHLRPCAG-- 1367
W + +W+ CS CG G + + C + D C +RP P +R C+ PC+
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
Query: 1368 WKVGNWSKCSRNCSG-GFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA 1426
W W CSR+C G + R IQC+ + + + AG P C PC A
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
Query: 1427 -WQVEPWSQCSRSCGGGVQERGVFCPG-----GLCDWTKRPTSTMSCNEHLCCHWATGNW 1480
W++ WSQCS +CG G+Q+R V C G C+ RP + C+
Sbjct: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCE-GDRPDTVQVCS------------ 1020
Query: 1481 DLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCT 1540
+CGG Q TV+ E E Q P+ N K S+ CT
Sbjct: 1021 ---LPACGGNHQNSTVRADVWELGTPEGQ------WVPQSEPLHPIN----KISSTEPCT 1067
Query: 1541 KDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
D+ + FCQ + CS+P CC SC
Sbjct: 1068 GDR--SVFCQMEVLDRYCSIPGYHRLCCVSC 1096
Score = 47.8 bits (112), Expect = 9e-05
Identities = 24/55 (43%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQMDS--DCAAIQRPDPAKRCHLRPCAG 1367
A W +G WS+CS TCG G R+V C T +S C RPD + C L C G
Sbjct: 973 AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1026
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 435 bits (1119), Expect = e-121
Identities = 307/1025 (29%), Positives = 472/1025 (46%), Gaps = 105/1025 (10%)
Query: 44 HFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLD------------------ 85
H L +Y V P D G FLS+ + P +S +D
Sbjct: 30 HLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSP 89
Query: 86 ---GSEDW--------VYYRISHEEKDLFFNLTVNQGFL--SNSYIMEKRYGNLSHVKMM 132
G W +Y+ ++ K+L L N+ + +S ++ + L +
Sbjct: 90 LHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLR 149
Query: 133 ASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKK-HPLVEGGYHP 191
C +G V G A+S C GL G + DFFIEP+++ E
Sbjct: 150 QE----CVYTGGVT--GMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRT 203
Query: 192 HIVYRRQKVP-ETKEP-------TCGLKDSVNISQK--QELWREKWERHNLPSRSLSRRS 241
H+VYRR+ V E EP GL D N+ +L + +R + S S
Sbjct: 204 HVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYS--- 260
Query: 242 ISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILL 301
+E L+V D ++ +HG E+V++Y+LT+MN+V ++H+ S+G I+I +VRLI++
Sbjct: 261 ------IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMV 314
Query: 302 EEEEQGLKIVHHAE--KTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCE 359
Q L ++ ++L C+W S + + HHD V LTR+D
Sbjct: 315 GYR-QSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS------ 367
Query: 360 TLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIM 419
G + ++GMC P RSC +N + G AF IAHE GH G++HDG+ N C +M
Sbjct: 368 --GYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 425
Query: 420 SRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQ 479
+ +Q WS+CS+ ++R+L CL D P PG+ Y + QC+
Sbjct: 426 APLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCR 483
Query: 480 LQYGPNATFCQEVENV--CQTLWCSVKG---FCRSKLDAAADGTQCGEKKWCMAGKCITV 534
+G C C+ LWCS FC++K DGT+C KWC G CI
Sbjct: 484 FDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW- 542
Query: 535 GKKPESI---PGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLC 591
K PE GGW W+ + CSR+CG GV+S R CNNP P +GG+ C G Y++C
Sbjct: 543 -KSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVC 601
Query: 592 NVHPCRSEAPTFRQMQCSEFDT-VPYKNELYHWFPIFNP---AHPCELYCRPIDGQFSEK 647
N C FR QC++ ++ ++N + W P + P A CEL C+ D
Sbjct: 602 NSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVP-YEPDDDAQKCELICQSADTGDVVF 660
Query: 648 MLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVR-K 706
M V DGT C + +VC G C VGCD E+ S +D+CGVC GD S C+TV+
Sbjct: 661 MNQVVHDGTRC-SYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGT 719
Query: 707 MFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYK 766
+ K + +G + + IP GAR I++ +E + + + ++++ + LN + +
Sbjct: 720 LGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFT 779
Query: 767 LAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPG----IKYEYTIQKDGL----D 818
G ++ + E L +GP E++ I L T G + Y+Y I +D L
Sbjct: 780 AMGLEWEDAVEDAKESLKTSGPLPEAIAI-LALPPTEGGPRSSLAYKYVIHEDLLPLIGS 838
Query: 819 NDV---EQQMYFWQYGHWTECSVTCGTGIRRQTAHC-IKKGRGMVKATFCDPETQPNGRQ 874
N+V E Y W W CS CG GI+ C ++ MV+ CD + +P +
Sbjct: 839 NNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIR 898
Query: 875 KKCHEKAC-PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPK 933
++C++ C P W EW ACS +CG G + R + C+ + + + P +P+
Sbjct: 899 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 958
Query: 934 TLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE--PCDVTRKPNSRALC 991
C R + CP+ W +G WS+CS +CG G++ R V C N + C+ R P++ +C
Sbjct: 959 ARRPCLR-VPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDR-PDTVQVC 1016
Query: 992 GLQQC 996
L C
Sbjct: 1017 SLPAC 1021
Score = 101 bits (251), Expect = 7e-21
Identities = 79/271 (29%), Positives = 111/271 (40%), Gaps = 44/271 (16%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPAKR-CHLRPCAG-- 1367
W + +W+ CS CG G + + C + D C +RP P +R C+ PC+
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 910
Query: 1368 WKVGNWSKCSRNCSG-GFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA 1426
W W CSR+C G + R IQC+ + + + AG P C PC A
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 970
Query: 1427 -WQVEPWSQCSRSCGGGVQERGVFCPG-----GLCDWTKRPTSTMSCNEHLCCHWATGNW 1480
W++ WSQCS +CG G+Q+R V C G C+ RP + C+
Sbjct: 971 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCE-GDRPDTVQVCS------------ 1017
Query: 1481 DLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCT 1540
+CGG Q TV+ E E Q P+ N K S+ CT
Sbjct: 1018 ---LPACGGNHQNSTVRADVWELGTPEGQ------WVPQSEPLHPIN----KISSTEPCT 1064
Query: 1541 KDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
D+ + FCQ + CS+P CC SC
Sbjct: 1065 GDR--SVFCQMEVLDRYCSIPGYHRLCCVSC 1093
Score = 47.8 bits (112), Expect = 9e-05
Identities = 24/55 (43%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQMDS--DCAAIQRPDPAKRCHLRPCAG 1367
A W +G WS+CS TCG G R+V C T +S C RPD + C L C G
Sbjct: 970 AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1023
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 430 bits (1106), Expect = e-120
Identities = 285/860 (33%), Positives = 434/860 (50%), Gaps = 77/860 (8%)
Query: 84 LDGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSG 143
L GS + +S K L + FL+ + +E R G C SG
Sbjct: 46 LPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIE-RLGGSGRATGGERGLRGCFFSG 104
Query: 144 TVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEP-------VKKHPLVEGGYHPHIVYR 196
TV G AA+S C GL+G F L +F I+P + H L G P
Sbjct: 105 TV--NGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWG--PAGARP 160
Query: 197 RQKVPETKEPTCG---------LKDSVNISQKQELWREKWERHNLPSRSLSRRSISKERW 247
+ PE + T +DS SQ++E L + S ++R +S+ R+
Sbjct: 161 LPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARF 220
Query: 248 VETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQG 307
VETL+VAD M ++G++ ++++ILT+M++ ++ +PSI N+I+++VV+++++E+E+ G
Sbjct: 221 VETLLVADASMAAFYGAD-LQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWG 279
Query: 308 LKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLS 367
++ + TL +FC WQ+ N SD +P H+D A+LLTR++ C G C+TLG++ +
Sbjct: 280 PEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFC-GQEGLCDTLGVADIG 338
Query: 368 GMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCE---PVGRHPYIMSRQLQ 424
+C P++SC++ ED GL A T+AHELGH + HD + P+G+H ++M+
Sbjct: 339 TICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKH-HVMAPLFV 397
Query: 425 YDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPG--VIYDVHHQCQLQY 482
+ L WS CS Y+T LD G G CL D P L PG +Y + QC+ +
Sbjct: 398 HLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAA-ALPLPTGLPGRMALYQLDQQCRQIF 456
Query: 483 GPNATFCQEV--ENVCQTLWCSVKG---FCRSKLDAA--ADGTQCGEKKWCMAGKCITVG 535
GP+ C ++VC LWC G C +K + ADGT CG C G C+
Sbjct: 457 GPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEE 516
Query: 536 KKPESIP---GGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCN 592
+ P GGW W PW CSRTCG GVQ + R C +PEP+ GG+YC G R +Y+ C+
Sbjct: 517 EVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCH 576
Query: 593 VHPCRSEAPTFRQMQCSEFDTVPYKN---ELYHWFPIF---NPAHPCELYCRPIDGQFSE 646
C + +FR+ QC +++ Y + L W P + +P C+L+CR G+
Sbjct: 577 TEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCR-ARGRSEF 635
Query: 647 KMLDA-VIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVR 705
K+ +A VIDGT C G + +C+ G C GCD+ +DS D+CGVC G G+SC+ V
Sbjct: 636 KVFEAKVIDGTLC--GPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVS 693
Query: 706 KMFKQKEGSGYVDIGLIPKGARDIRVME-----IEGAGNFLAIRSEDPEKYYLNGGFIIQ 760
GY DI IP GA +I V + ++ GN+LA+++ D + Y LNG I
Sbjct: 694 GSL-TPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQ-YLLNGNLAIS 751
Query: 761 -WNGNYKLAGTVFQYDRK-GDLEKLMATGPTNESVWIQLLF---QVTNPGIKYEYTIQKD 815
+ + GT+ +Y LE+L + P E + +QLL +V P +KY + + D
Sbjct: 752 AIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPND 811
Query: 816 -----------GLDNDVEQQMYF-WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATF 863
N ++ ++ W G W+ECS TCG G +R+T C + G AT
Sbjct: 812 VDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVEC-RDPSGQASAT- 869
Query: 864 CDPETQPNGRQKKCHEKACP 883
C+ +P K C + CP
Sbjct: 870 CNKALKPED-AKPCESQLCP 888
Score = 53.1 bits (126), Expect = 2e-06
Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC---STQMDSDCAAIQRPDPAKRCHLRPC 1365
A W++G+WSECS+TCG G R VEC S Q + C +P+ AK C + C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 51.6 bits (122), Expect = 6e-06
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 5/74 (6%)
Query: 1458 TKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHK 1517
+K +T L W G+W CS++CG G+Q+RTV+C G Q C+
Sbjct: 819 SKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSG-----QASATCNKA 873
Query: 1518 PRPPEFKKCNQQAC 1531
+P + K C Q C
Sbjct: 874 LKPEDAKPCESQLC 887
Score = 45.1 bits (105), Expect = 6e-04
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 3/58 (5%)
Query: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTC---AKNHDEPCDVTRKPNSRALCGLQQCP 997
L + W +G+WSECS +CG G + R+V C + C+ KP C Q CP
Sbjct: 831 LLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
Score = 39.3 bits (90), Expect = 0.031
Identities = 19/52 (36%), Positives = 24/52 (46%), Gaps = 6/52 (11%)
Query: 1427 WQVEPWSQCSRSCGGGVQERGVFC--PGG----LCDWTKRPTSTMSCNEHLC 1472
W + WS+CS +CG G Q R V C P G C+ +P C LC
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 37.7 bits (86), Expect = 0.089
Identities = 21/63 (33%), Positives = 26/63 (41%), Gaps = 20/63 (31%)
Query: 830 YGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQ--------KKCHEKA 881
+G W ECS TCG G++ C DPE Q GR + CH +
Sbjct: 532 WGPWGECSRTCGGGVQFSHRECK------------DPEPQNGGRYCLGRRAKYQSCHTEE 579
Query: 882 CPP 884
CPP
Sbjct: 580 CPP 582
Score = 36.2 bits (82), Expect = 0.26
Identities = 12/28 (42%), Positives = 19/28 (67%)
Query: 1366 AGWKVGNWSKCSRNCSGGFKIREIQCVD 1393
A W +G+WS+CS C G++ R ++C D
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRD 861
Score = 35.4 bits (80), Expect = 0.44
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 18/83 (21%)
Query: 1312 HGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKV- 1370
+GS W G T CG G C + + ++RP P GW
Sbjct: 490 NGSLPWADG------TPCGPGHLCSEGSCLPEEE-----VERPKPVAD------GGWAPW 532
Query: 1371 GNWSKCSRNCSGGFKIREIQCVD 1393
G W +CSR C GG + +C D
Sbjct: 533 GPWGECSRTCGGGVQFSHRECKD 555
Score = 34.3 bits (77), Expect = 0.99
Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 13/69 (18%)
Query: 1475 WAT-GNWDLCSTSCGGGFQKRTVQCVPSE---------GNKTEDQDQCLCDHKPRPPEFK 1524
WA G W CS +CGGG Q +C E G + + Q C + PP+ K
Sbjct: 529 WAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQS---CHTEECPPDGK 585
Query: 1525 KCNQQACKK 1533
+Q C+K
Sbjct: 586 SFREQQCEK 594
Score = 33.5 bits (75), Expect = 1.7
Identities = 11/14 (78%), Positives = 13/14 (92%)
Query: 1431 PWSQCSRSCGGGVQ 1444
PW +CSR+CGGGVQ
Sbjct: 534 PWGECSRTCGGGVQ 547
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 397 bits (1019), Expect = e-110
Identities = 271/818 (33%), Positives = 385/818 (47%), Gaps = 91/818 (11%)
Query: 139 CHLSGTVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKHPLVE---------GGY 189
C GTV G+ A C GL GFF + H + ++P+ + P E G
Sbjct: 130 CFYRGTV--DGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSA 187
Query: 190 HPHIVYRRQKVP-ETKEPTCGLKDSVNISQKQE--------LWREKWERHNLPSRSLS-- 238
VY R+ E P + + + E R L +LS
Sbjct: 188 RILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPA 247
Query: 239 ------------RRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPS 286
RRSIS+ R VE L+VAD M +G ++ Y+LT+ ++ L+ + S
Sbjct: 248 GGSGPQTWWRRRRRSISRARQVELLLVADASMARLYG-RGLQHYLLTLASIANRLYSHAS 306
Query: 287 IGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLT 346
I N I + VV++++L ++++ L++ +A TL +FCKWQ N D + H+D A+L T
Sbjct: 307 IENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFT 366
Query: 347 RKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKE 406
R+D+C + C+TLG++ + +C P RSC + ED GL AFT+AHE+GH G+ HD +
Sbjct: 367 REDLCG--HHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSK 424
Query: 407 NDCEPVG--RHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSK 464
E G +MS L WSKC+ IT FLD G G CL D+P+K+ L +
Sbjct: 425 FCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPE 484
Query: 465 VIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSV----KGFCRSKLDAAADGTQC 520
+ PG YD QC L +GP + C ++ VC LWC+V + C +K A +GT C
Sbjct: 485 EL-PGQTYDATQQCNLTFGPEYSVCPGMD-VCARLWCAVVRQGQMVCLTKKLPAVEGTPC 542
Query: 521 GEKKWCMAGKCITVGKKP---ESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFG 577
G+ + C+ GKC+ KK S G WG W W CSR+CG GVQ A R CNNP P+
Sbjct: 543 GKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNN 602
Query: 578 GKYCTGERKRYRLCNVHPCRSEAPTFRQMQCS-----EFDTVPYKNELYHWFPIFN---P 629
G+YCTG+R YR C++ PC +FR QC + D K W P + P
Sbjct: 603 GRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKT-FVEWVPKYAGVLP 661
Query: 630 AHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATED 689
A C+L CR + V DGT C NS VC+ G C GCD I S D
Sbjct: 662 ADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNS--VCVRGKCVRTGCDGIIGSKLQYD 719
Query: 690 RCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGN-----FLAIR 744
+CGVC GD SSC + F K+ GY D+ IP+GA I+V + + +LA++
Sbjct: 720 KCGVCGGDNSSCTKIVGTF-NKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALK 778
Query: 745 SEDPEKYYLNGGFIIQWNGN-YKLAGTVFQY---DRKGDLEKLMATGPTNESVWIQLLFQ 800
++ E Y +NG ++I + + GTV Y + D M T E + +Q+L
Sbjct: 779 KKNGE-YLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQIL-- 835
Query: 801 VTNP----GIKYEYTIQKDGLD--NDV----------EQQMYFWQYGHWTECSVTCGTGI 844
T+P ++Y + + K N V W G W CS TC TG
Sbjct: 836 ATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGW 895
Query: 845 RRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKAC 882
+T C R + K P +Q K+C K C
Sbjct: 896 HTRTVQCQDGNRKLAKGC---PLSQRPSAFKQCLLKKC 930
Score = 44.3 bits (103), Expect = 0.001
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVEC---STQMDSDCAAIQRPDPAKRCHLRPC 1365
W+ G W CS TC G + R V+C + ++ C QRP K+C L+ C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 43.5 bits (101), Expect = 0.002
Identities = 22/57 (38%), Positives = 29/57 (50%), Gaps = 5/57 (8%)
Query: 1475 WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W TG W CS +C G+ RTVQC +GN+ + C RP FK+C + C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQC--QDGNRKLAKG---CPLSQRPSAFKQCLLKKC 930
Score = 37.4 bits (85), Expect = 0.12
Identities = 26/112 (23%), Positives = 41/112 (36%), Gaps = 20/112 (17%)
Query: 830 YGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQ--------KKCHEKA 881
+G W +CS +CG G++ HC +P + NGR + C
Sbjct: 573 WGSWGQCSRSCGGGVQFAYRHCN------------NPAPRNNGRYCTGKRAIYRSCSLMP 620
Query: 882 CPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPK 933
CPP + E C A G + K ++ + LP C+ + K
Sbjct: 621 CPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAK 672
Score = 36.6 bits (83), Expect = 0.20
Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 6/67 (8%)
Query: 951 GNWSECSVSCGGGVRIRSVTC----AKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPN 1006
G+W +CS SCGGGV+ C +N+ C T K C L CP + + +
Sbjct: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC--TGKRAIYRSCSLMPCPPNGKSFRHE 631
Query: 1007 KGTISNG 1013
+ NG
Sbjct: 632 QCEAKNG 638
Score = 34.7 bits (78), Expect = 0.76
Identities = 15/52 (28%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 948 WTVGNWSECSVSCGGGVRIRSVTCAKNH---DEPCDVTRKPNSRALCGLQQC 996
W G W CS +C G R+V C + + C ++++P++ C L++C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 34.3 bits (77), Expect = 0.99
Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 12/95 (12%)
Query: 1446 RGVFCPGGLC-DWTKRPTSTMSCNEHLCCHWAT-GNWDLCSTSCGGGFQKRTVQC---VP 1500
+G C G C D TK+ + S + + W + G+W CS SCGGG Q C P
Sbjct: 544 KGRICLQGKCVDKTKKKYYSTSSHGN----WGSWGSWGQCSRSCGGGVQFAYRHCNNPAP 599
Query: 1501 SEGNKTEDQDQCL---CDHKPRPPEFKKCNQQACK 1532
+ + + C P PP K + C+
Sbjct: 600 RNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCE 634
Score = 33.9 bits (76), Expect = 1.3
Identities = 12/26 (46%), Positives = 14/26 (53%)
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVD 1393
W G W CSR C G+ R +QC D
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQD 904
Score = 33.1 bits (74), Expect = 2.2
Identities = 12/13 (92%), Positives = 12/13 (92%)
Query: 1432 WSQCSRSCGGGVQ 1444
W QCSRSCGGGVQ
Sbjct: 576 WGQCSRSCGGGVQ 588
Score = 33.1 bits (74), Expect = 2.2
Identities = 16/47 (34%), Positives = 21/47 (44%), Gaps = 6/47 (12%)
Query: 1427 WQVEPWSQCSRSCGGGVQERGVFCPGGL------CDWTKRPTSTMSC 1467
W PW CSR+C G R V C G C ++RP++ C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQC 925
Score = 31.2 bits (69), Expect = 8.4
Identities = 20/64 (31%), Positives = 26/64 (40%), Gaps = 10/64 (15%)
Query: 1371 GNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGI--------PPPLSMSCNPE 1422
G+W +CSR+C GG + C + N R +C I PP S E
Sbjct: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGR--YCTGKRAIYRSCSLMPCPPNGKSFRHE 631
Query: 1423 PCEA 1426
CEA
Sbjct: 632 QCEA 635
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 380 bits (976), Expect = e-105
Identities = 236/656 (35%), Positives = 339/656 (51%), Gaps = 54/656 (8%)
Query: 130 KMMASSAPLCHLSGTVLQQGTRVGTAALSACHG-LTGFFQLPHGDFFIEPVKKH-PLVEG 187
+++ + P +L+GT+ G A+L G L G Q + ++P++ P G
Sbjct: 117 ELLGGAEPGTYLTGTI--NGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAG 174
Query: 188 GYHPHIVYRRQKVPETKEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRRSISKERW 247
G HI+ RR+ + P C +K + P ++R S R+
Sbjct: 175 GPGAHIL-RRKSPASGQGPMCNVKAPLGSPS--------------PRPRRAKRFASLSRF 219
Query: 248 VETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQG 307
VETLVVAD KM +HG+ ++ Y+LT+M F +PSI N + +VV RL++L E+G
Sbjct: 220 VETLVVADDKMAAFHGA-GLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEG 278
Query: 308 LKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLS 367
++ A +TL SFC WQ+ +N D +P H D A+L TR+D+C C+TLG++ +
Sbjct: 279 PQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVST--CDTLGMADVG 336
Query: 368 GMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCE---PVGRHPYIMSRQLQ 424
+C P RSC I ED GL AFT AHELGH F + HD + P+ ++M+ +
Sbjct: 337 TVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMA 396
Query: 425 YDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGP 484
+ WS CS +IT FLD G+G CL D P+ L V PG YD QCQL +GP
Sbjct: 397 HVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAP-LHLPVTFPGKDYDADRQCQLTFGP 455
Query: 485 NATFCQEVENVCQTLWCSVK----GFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPE- 539
++ C ++ C LWCS C++K ADGT CG + CM G+C+ + + +
Sbjct: 456 DSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDF 515
Query: 540 SIP--GGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC- 596
+IP GGWG W PW CSRTCG GVQ + R C P P+ GGKYC G R R+R CN C
Sbjct: 516 NIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCP 575
Query: 597 RSEAPTFRQMQCSEFDTVPYKNELY-------HWFPIFN---PAHPCELYCRPIDGQFSE 646
A TFR+ QC+ ++ ++ +L+ W P + P C+L C+ +
Sbjct: 576 TGSALTFREEQCAAYN---HRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYY 632
Query: 647 KMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRK 706
+ V+DGTPC +S +VC+ G C GCD I S D+C VC GDGS C
Sbjct: 633 VLEPRVVDGTPC--SPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSG 690
Query: 707 MFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGN---FLAIRSEDPEKYYLNGGFII 759
F+ K GY ++ IP GA I V + G+ +LA++ D Y LNG + +
Sbjct: 691 SFR-KFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPD-GSYALNGEYTL 744
Score = 35.0 bits (79), Expect = 0.58
Identities = 22/72 (30%), Positives = 32/72 (44%), Gaps = 12/72 (16%)
Query: 1478 GNWDLCSTSCGGGFQKRTVQC---VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKS 1534
G W CS +CGGG Q + C VP G K C+ R F+ CN + C
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGK-------YCE--GRRTRFRSCNTEDCPTG 577
Query: 1535 ADLLCTKDKLSA 1546
+ L +++ +A
Sbjct: 578 SALTFREEQCAA 589
Score = 35.0 bits (79), Expect = 0.58
Identities = 20/49 (40%), Positives = 22/49 (44%), Gaps = 9/49 (18%)
Query: 1431 PWSQCSRSCGGGVQERGVFCP-------GGLCDWTKRPTSTMSCNEHLC 1472
PW CSR+CGGGVQ C G C+ R T SCN C
Sbjct: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE--GRRTRFRSCNTEDC 574
Score = 34.7 bits (78), Expect = 0.76
Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 6/52 (11%)
Query: 951 GNWSECSVSCGGGVRIRSVTCA----KNHDEPCDVTRKPNSRALCGLQQCPS 998
G W +CS +CGGGV+ S C +N + C+ R+ R+ C + CP+
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCE-GRRTRFRS-CNTEDCPT 576
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 372 bits (954), Expect = e-102
Identities = 247/797 (30%), Positives = 363/797 (45%), Gaps = 61/797 (7%)
Query: 235 RSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIV 294
R RR+ +E LV + + H E+ E Y+LT +N+ L +PS+G +
Sbjct: 69 RQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVH 127
Query: 295 VVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDI-CAG 353
+V++++L E E I + +L S C W ++INP+ D +P H D+ + +TR D+
Sbjct: 128 LVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 354 FNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKEND-CEPV 412
NR + G++ L G C P SC I ED+G L TIAHE+GHSFG++HDG C P
Sbjct: 188 GNR--QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 413 GRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKS---KVIAPG 469
G ++M+ L WS CS + L G C+ D P+ + + PG
Sbjct: 246 G---HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPG 302
Query: 470 VIYDVHHQCQLQYGPNA---TFCQEVENVCQTLWCSV----KGFCRSKLDAAADGTQCGE 522
+ Y + QC++ +GP A TF +E ++CQ L C + C L DGT+CG
Sbjct: 303 LYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGV 362
Query: 523 KKWCMAGKCITVGKKPE--SIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKY 580
+KWC G+C ++ + ++ G W W P S CSR+CG GV + R CNNP P FGG+
Sbjct: 363 EKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRA 422
Query: 581 CTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKN-----ELYHW---FPIFNPAHP 632
C G + +CN C F QC+ D P ++ YHW P
Sbjct: 423 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 482
Query: 633 CELYCRPIDGQFSEKMLDAVIDGTPCFEGG----NSRNVCINGICKMVGCDYEIDSNATE 688
C CR I F K D+ +DGT C G + ++C++G C+ GCD +DS
Sbjct: 483 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 542
Query: 689 DRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDP 748
DRC VC GD S+C + F YV + + + LA+R
Sbjct: 543 DRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGG- 601
Query: 749 EKYYLNGGFIIQWNGNYK--LAGTVFQY------DRKGDLEKLMATGPTNESVWIQLLFQ 800
+Y + G I N Y L +Y DR LE++ GP E IQ+ +
Sbjct: 602 -RYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 660
Query: 801 -------VTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIK 853
+T P I + Y K +Q + W CSV+CG G+R C+
Sbjct: 661 YGEEYGNLTRPDITFTYFQPK-------PRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLD 712
Query: 854 KGR-GMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQ 912
+ R +V+ C QP + C + CPP W G++ CSA+CG G ++R V C++
Sbjct: 713 QARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG-GGLRERPVRCVE 771
Query: 913 TMVSDEQALPPTDCQ-HLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTC 971
S + LPP C+ +P L CP+ W V S C+ + G G+ + + TC
Sbjct: 772 AQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETC 831
Query: 972 AKNHDE-PCDVTRKPNS 987
D VT P S
Sbjct: 832 VPGADGLEAPVTEGPGS 848
Score = 90.9 bits (224), Expect = 9e-18
Identities = 52/149 (34%), Positives = 74/149 (49%), Gaps = 9/149 (6%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKK-----GRGMVKATFCDPETQPNGRQKKCHEKAC 882
WQY CSV+CG G+ R+ +C + G ++ T C +P Q+ C + C
Sbjct: 955 WQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPC 1012
Query: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDI 942
PPRW CSA+CG G +R+V C+Q + + C L++P+ + C
Sbjct: 1013 PPRWKVMSLGPCSASCGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC-LIA 1070
Query: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTC 971
C W VG W ECSVSCG G++ R TC
Sbjct: 1071 DCTYRWHVGTWMECSVSCGDGIQRRRDTC 1099
Score = 81.3 bits (199), Expect = 7e-15
Identities = 69/255 (27%), Positives = 95/255 (37%), Gaps = 32/255 (12%)
Query: 1303 SNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ------MDSDCAAIQRPDP 1356
S + + G +AH CS +CG G R C + C +P
Sbjct: 882 SPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGS 941
Query: 1357 AKR-CHLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRN----LRPFHCQFLAG 1410
+ C PC A W+ + CS +C G R + C + + L CQ G
Sbjct: 942 RREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQ---G 997
Query: 1411 IPPPLSM-SCNPEPCEA-WQVEPWSQCSRSCGGGVQERGVFC-----------PGGLCDW 1457
+P P +C+ EPC W+V CS SCG G R V C C
Sbjct: 998 LPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAA 1057
Query: 1458 TKRPTSTMSCNEHLCCH-WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDH 1516
RP +++ C C + W G W CS SCG G Q+R C+ + D C H
Sbjct: 1058 LVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPAD--FCQH 1115
Query: 1517 KPRPPEFKKCNQQAC 1531
P+P + C C
Sbjct: 1116 LPKPVTVRGCWAGPC 1130
Score = 79.3 bits (194), Expect = 3e-14
Identities = 54/179 (30%), Positives = 79/179 (44%), Gaps = 18/179 (10%)
Query: 833 WT----ECSVTCGTGIRRQTAHCIKKG-RGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
WT CSV+CG G+ C+ R V+ C ++P R++ C CP RW
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQ 956
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSD--EQALPPTDCQHLLKPKTLLSCNRDILCP 945
+ ACS +CG G +R + C + D E+ L T CQ L +P+ +C+ + CP
Sbjct: 957 Y-KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEP-CP 1013
Query: 946 SDWTVGNWSECSVSCGGGVRIRSVTC--------AKNHDEPCDVTRKPNSRALCGLQQC 996
W V + CS SCG G RSV C + + C +P + C + C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1072
Score = 79.0 bits (193), Expect = 4e-14
Identities = 47/141 (33%), Positives = 68/141 (48%), Gaps = 13/141 (9%)
Query: 1325 CSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPA--KRCHLRPCAG-WKVGNWSK 1375
CS +CG G W C Q + C Q+P PA + C L PC W VG++
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQP-PAWPEACVLEPCPPYWAVGDFGP 753
Query: 1376 CSRNCSGGFKIREIQCVDSRDH--RNLRPFHCQFLAGIPPPLSMSCNPEPCEA-WQVEPW 1432
CS +C GG + R ++CV+++ + L P C+ A P +CNP+PC A W+V
Sbjct: 754 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 813
Query: 1433 SQCSRSCGGGVQERGVFCPGG 1453
S C+ + G G+ C G
Sbjct: 814 SSCTSAGGAGLALENETCVPG 834
Score = 64.3 bits (155), Expect = 9e-10
Identities = 69/273 (25%), Positives = 98/273 (35%), Gaps = 62/273 (22%)
Query: 1316 HWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDC-AAIQRPDPA-KRCHLRPC 1365
+W VG++ CS +CG G R V C T + C A Q+P A + C+ +PC
Sbjct: 745 YWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPC 804
Query: 1366 -AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFH-----CQFLAGIPPPLSMSC 1419
A W+V S C+ G + CV D + L P + MSC
Sbjct: 805 PARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSC 864
Query: 1420 NP-----EPCEAWQ--VEPW-----------------SQCSRSCGGGVQERGVFCPGG-- 1453
P + A + PW CS SCG G+ E C
Sbjct: 865 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSAL 924
Query: 1454 -------LCDWTKRPTSTMSCNEHLCCHWATGNWD----LCSTSCGGGFQKRTVQCVPSE 1502
LC +P S + + C W CS SCG G +R + C +
Sbjct: 925 RVPVQEELCGLASKPGSRREVCQAVPC---PARWQYKLAACSVSCGRGVVRRILYCARAH 981
Query: 1503 GNKTEDQDQCL----CDHKPRPPEFKKCNQQAC 1531
G +D ++ L C PRP + C+ + C
Sbjct: 982 GE--DDGEEILLDTQCQGLPRPEPQEACSLEPC 1012
Score = 55.5 bits (132), Expect = 4e-07
Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 20/128 (15%)
Query: 1421 PEPCEAWQVEPWSQ----CSRSCGGGV---------QERGVFCPGGLCDWTKRPTS-TMS 1466
P+P +AW W+ CS SCG G+ Q R C +++P + +
Sbjct: 680 PKPRQAWV---WAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEA 736
Query: 1467 CNEHLCC-HWATGNWDLCSTSCGGGFQKRTVQCVPSEGN--KTEDQDQCLCDHKPRPPEF 1523
C C +WA G++ CS SCGGG ++R V+CV ++G+ KT +C +
Sbjct: 737 CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 796
Query: 1524 KKCNQQAC 1531
+ CN Q C
Sbjct: 797 ETCNPQPC 804
Score = 52.8 bits (125), Expect = 3e-06
Identities = 47/218 (21%), Positives = 78/218 (35%), Gaps = 48/218 (22%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPET--QPNGRQKKCHEKACPPR 885
W+ + C+ G G+ + C+ G+ P + + + C +CPP
Sbjct: 808 WEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG 867
Query: 886 W----------------------------WAGEWEACSATCGPHGEKKRTVLCIQTMVSD 917
W W +CS +CG G + LC+ + +
Sbjct: 868 WGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCG-RGLMELRFLCMDSALR- 925
Query: 918 EQALPPTD--CQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH 975
+P + C KP + + + CP+ W + CSVSCG GV R + CA+ H
Sbjct: 926 ---VPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAH 981
Query: 976 ----------DEPCDVTRKPNSRALCGLQQCPSSRRVL 1003
D C +P + C L+ CP +V+
Sbjct: 982 GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 1019
Score = 42.4 bits (98), Expect = 0.004
Identities = 19/46 (41%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 826 YFWQYGHWTECSVTCGTGIRRQTAHCI-KKGRGMVKATFCDPETQP 870
Y W G W ECSV+CG GI+R+ C+ + + V A FC +P
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP 1119
Score = 41.6 bits (96), Expect = 0.006
Identities = 50/169 (29%), Positives = 66/169 (39%), Gaps = 19/169 (11%)
Query: 1348 CAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRP-FHCQ 1406
C ++ P H R + W G S CSR+C GG R QC N RP F +
Sbjct: 371 CRSLVELTPIAAVHGR-WSSW--GPRSPCSRSCGGGVVTRRRQC------NNPRPAFGGR 421
Query: 1407 FLAGIPPPLSMSCNPEPCEAWQVEPWS-QCSRSCGGGVQERGVFCPGGLCDWTKRPTSTM 1465
G M CN + CE Q+E S QC+R+ G ++ PGG +
Sbjct: 422 ACVGADLQAEM-CNTQACEKTQLEFMSQQCARTDGQPLRS----SPGGASFYHWGAAVPH 476
Query: 1466 SCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLC 1514
S + LC H + G F T +C+PS ED LC
Sbjct: 477 SQGDALCRHMCRAIGESFIMKRGDSFLDGT-RCMPS--GPREDGTLSLC 522
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 372 bits (954), Expect = e-102
Identities = 247/797 (30%), Positives = 363/797 (45%), Gaps = 61/797 (7%)
Query: 235 RSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIV 294
R RR+ +E LV + + H E+ E Y+LT +N+ L +PS+G +
Sbjct: 69 RQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVH 127
Query: 295 VVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDI-CAG 353
+V++++L E E I + +L S C W ++INP+ D +P H D+ + +TR D+
Sbjct: 128 LVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 354 FNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKEND-CEPV 412
NR + G++ L G C P SC I ED+G L TIAHE+GHSFG++HDG C P
Sbjct: 188 GNR--QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 413 GRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKS---KVIAPG 469
G ++M+ L WS CS + L G C+ D P+ + + PG
Sbjct: 246 G---HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPG 302
Query: 470 VIYDVHHQCQLQYGPNA---TFCQEVENVCQTLWCSV----KGFCRSKLDAAADGTQCGE 522
+ Y + QC++ +GP A TF +E ++CQ L C + C L DGT+CG
Sbjct: 303 LYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGV 362
Query: 523 KKWCMAGKCITVGKKPE--SIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKY 580
+KWC G+C ++ + ++ G W W P S CSR+CG GV + R CNNP P FGG+
Sbjct: 363 EKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRA 422
Query: 581 CTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKN-----ELYHW---FPIFNPAHP 632
C G + +CN C F QC+ D P ++ YHW P
Sbjct: 423 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 482
Query: 633 CELYCRPIDGQFSEKMLDAVIDGTPCFEGG----NSRNVCINGICKMVGCDYEIDSNATE 688
C CR I F K D+ +DGT C G + ++C++G C+ GCD +DS
Sbjct: 483 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 542
Query: 689 DRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDP 748
DRC VC GD S+C + F YV + + + LA+R
Sbjct: 543 DRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGG- 601
Query: 749 EKYYLNGGFIIQWNGNYK--LAGTVFQY------DRKGDLEKLMATGPTNESVWIQLLFQ 800
+Y + G I N Y L +Y DR LE++ GP E IQ+ +
Sbjct: 602 -RYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 660
Query: 801 -------VTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIK 853
+T P I + Y K +Q + W CSV+CG G+R C+
Sbjct: 661 YGEEYGNLTRPDITFTYFQPK-------PRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLD 712
Query: 854 KGR-GMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQ 912
+ R +V+ C QP + C + CPP W G++ CSA+CG G ++R V C++
Sbjct: 713 QARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG-GGLRERPVRCVE 771
Query: 913 TMVSDEQALPPTDCQ-HLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTC 971
S + LPP C+ +P L CP+ W V S C+ + G G+ + + TC
Sbjct: 772 AQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETC 831
Query: 972 AKNHDE-PCDVTRKPNS 987
D VT P S
Sbjct: 832 VPGADGLEAPVTEGPGS 848
Score = 93.2 bits (230), Expect = 2e-18
Identities = 70/238 (29%), Positives = 100/238 (42%), Gaps = 31/238 (13%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKK-----GRGMVKATFCDPETQPNGRQKKCHEKAC 882
WQY CSV+CG G+ R+ +C + G ++ T C +P Q+ C + C
Sbjct: 955 WQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPC 1012
Query: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDI 942
PPRW CSA+CG G +R+V C+Q + + C L++P+ + C
Sbjct: 1013 PPRWKVMSLGPCSASCGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC-LIA 1070
Query: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTC------AKNHDEPCDVTRKPNSRALCGLQQC 996
C W VG W ECSVSCG G++ R TC A + C KP + C C
Sbjct: 1071 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Query: 997 PSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPE-SMSTSTPAISSPSP 1053
G+ P+L P + R TP G S + + SP+P
Sbjct: 1131 V---------------GQGTPSLVPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAP 1173
Score = 81.3 bits (199), Expect = 7e-15
Identities = 69/255 (27%), Positives = 95/255 (37%), Gaps = 32/255 (12%)
Query: 1303 SNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ------MDSDCAAIQRPDP 1356
S + + G +AH CS +CG G R C + C +P
Sbjct: 882 SPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGS 941
Query: 1357 AKR-CHLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRN----LRPFHCQFLAG 1410
+ C PC A W+ + CS +C G R + C + + L CQ G
Sbjct: 942 RREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQ---G 997
Query: 1411 IPPPLSM-SCNPEPCEA-WQVEPWSQCSRSCGGGVQERGVFC-----------PGGLCDW 1457
+P P +C+ EPC W+V CS SCG G R V C C
Sbjct: 998 LPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAA 1057
Query: 1458 TKRPTSTMSCNEHLCCH-WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDH 1516
RP +++ C C + W G W CS SCG G Q+R C+ + D C H
Sbjct: 1058 LVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPAD--FCQH 1115
Query: 1517 KPRPPEFKKCNQQAC 1531
P+P + C C
Sbjct: 1116 LPKPVTVRGCWAGPC 1130
Score = 79.3 bits (194), Expect = 3e-14
Identities = 54/179 (30%), Positives = 79/179 (44%), Gaps = 18/179 (10%)
Query: 833 WT----ECSVTCGTGIRRQTAHCIKKG-RGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
WT CSV+CG G+ C+ R V+ C ++P R++ C CP R W
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR-W 955
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSD--EQALPPTDCQHLLKPKTLLSCNRDILCP 945
+ ACS +CG G +R + C + D E+ L T CQ L +P+ +C+ + CP
Sbjct: 956 QYKLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE-PCP 1013
Query: 946 SDWTVGNWSECSVSCGGGVRIRSVTC--------AKNHDEPCDVTRKPNSRALCGLQQC 996
W V + CS SCG G RSV C + + C +P + C + C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1072
Score = 79.0 bits (193), Expect = 4e-14
Identities = 47/141 (33%), Positives = 68/141 (48%), Gaps = 13/141 (9%)
Query: 1325 CSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPA--KRCHLRPCAG-WKVGNWSK 1375
CS +CG G W C Q + C Q+P PA + C L PC W VG++
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQP-PAWPEACVLEPCPPYWAVGDFGP 753
Query: 1376 CSRNCSGGFKIREIQCVDSRDH--RNLRPFHCQFLAGIPPPLSMSCNPEPCEA-WQVEPW 1432
CS +C GG + R ++CV+++ + L P C+ A P +CNP+PC A W+V
Sbjct: 754 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 813
Query: 1433 SQCSRSCGGGVQERGVFCPGG 1453
S C+ + G G+ C G
Sbjct: 814 SSCTSAGGAGLALENETCVPG 834
Score = 64.3 bits (155), Expect = 9e-10
Identities = 69/273 (25%), Positives = 98/273 (35%), Gaps = 62/273 (22%)
Query: 1316 HWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDC-AAIQRPDPA-KRCHLRPC 1365
+W VG++ CS +CG G R V C T + C A Q+P A + C+ +PC
Sbjct: 745 YWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPC 804
Query: 1366 -AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFH-----CQFLAGIPPPLSMSC 1419
A W+V S C+ G + CV D + L P + MSC
Sbjct: 805 PARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSC 864
Query: 1420 NP-----EPCEAWQ--VEPW-----------------SQCSRSCGGGVQERGVFCPGG-- 1453
P + A + PW CS SCG G+ E C
Sbjct: 865 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSAL 924
Query: 1454 -------LCDWTKRPTSTMSCNEHLCCHWATGNWD----LCSTSCGGGFQKRTVQCVPSE 1502
LC +P S + + C W CS SCG G +R + C +
Sbjct: 925 RVPVQEELCGLASKPGSRREVCQAVPC---PARWQYKLAACSVSCGRGVVRRILYCARAH 981
Query: 1503 GNKTEDQDQCL----CDHKPRPPEFKKCNQQAC 1531
G +D ++ L C PRP + C+ + C
Sbjct: 982 GE--DDGEEILLDTQCQGLPRPEPQEACSLEPC 1012
Score = 55.5 bits (132), Expect = 4e-07
Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 20/128 (15%)
Query: 1421 PEPCEAWQVEPWSQ----CSRSCGGGV---------QERGVFCPGGLCDWTKRPTS-TMS 1466
P+P +AW W+ CS SCG G+ Q R C +++P + +
Sbjct: 680 PKPRQAWV---WAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEA 736
Query: 1467 CNEHLCC-HWATGNWDLCSTSCGGGFQKRTVQCVPSEGN--KTEDQDQCLCDHKPRPPEF 1523
C C +WA G++ CS SCGGG ++R V+CV ++G+ KT +C +
Sbjct: 737 CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 796
Query: 1524 KKCNQQAC 1531
+ CN Q C
Sbjct: 797 ETCNPQPC 804
Score = 42.4 bits (98), Expect = 0.004
Identities = 19/46 (41%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 826 YFWQYGHWTECSVTCGTGIRRQTAHCI-KKGRGMVKATFCDPETQP 870
Y W G W ECSV+CG GI+R+ C+ + + V A FC +P
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP 1119
Score = 41.6 bits (96), Expect = 0.006
Identities = 50/169 (29%), Positives = 66/169 (39%), Gaps = 19/169 (11%)
Query: 1348 CAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRP-FHCQ 1406
C ++ P H R + W G S CSR+C GG R QC N RP F +
Sbjct: 371 CRSLVELTPIAAVHGR-WSSW--GPRSPCSRSCGGGVVTRRRQC------NNPRPAFGGR 421
Query: 1407 FLAGIPPPLSMSCNPEPCEAWQVEPWS-QCSRSCGGGVQERGVFCPGGLCDWTKRPTSTM 1465
G M CN + CE Q+E S QC+R+ G ++ PGG +
Sbjct: 422 ACVGADLQAEM-CNTQACEKTQLEFMSQQCARTDGQPLRS----SPGGASFYHWGAAVPH 476
Query: 1466 SCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLC 1514
S + LC H + G F T +C+PS ED LC
Sbjct: 477 SQGDALCRHMCRAIGESFIMKRGDSFLDGT-RCMPS--GPREDGTLSLC 522
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 352 bits (903), Expect = 2e-96
Identities = 240/794 (30%), Positives = 351/794 (44%), Gaps = 86/794 (10%)
Query: 235 RSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIV 294
R RR+ +E LV + + H E+ E Y+LT +N+ L +PS+G +
Sbjct: 69 RQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVH 127
Query: 295 VVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDI-CAG 353
+V++++L E E I + +L S C W ++INP+ D +P H D+ + +TR D+
Sbjct: 128 LVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 354 FNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKEND-CEPV 412
NR + G++ L G C P SC I ED+G L TIAHE+GHSFG++HDG C P
Sbjct: 188 GNR--QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 413 GRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIY 472
G ++M+ L WS CS + L
Sbjct: 246 G---HVMASDGAAPRAGLAWSPCSRRQLLSLLS--------------------------- 275
Query: 473 DVHHQCQLQYGPNA---TFCQEVENVCQTLWCSV----KGFCRSKLDAAADGTQCGEKKW 525
+ QC++ +GP A TF +E ++CQ L C + C L DGT+CG +KW
Sbjct: 276 -ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKW 334
Query: 526 CMAGKCITVGKKPE--SIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG 583
C G+C ++ + ++ G W W P S CSR+CG GV + R CNNP P FGG+ C G
Sbjct: 335 CSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 394
Query: 584 ERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKN-----ELYHW---FPIFNPAHPCEL 635
+ +CN C F QC+ D P ++ YHW P C
Sbjct: 395 ADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRH 454
Query: 636 YCRPIDGQFSEKMLDAVIDGTPCFEGG----NSRNVCINGICKMVGCDYEIDSNATEDRC 691
CR I F K D+ +DGT C G + ++C++G C+ GCD +DS DRC
Sbjct: 455 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 514
Query: 692 GVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKY 751
VC GD S+C + F YV + + + LA+R +Y
Sbjct: 515 QVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGG--RY 572
Query: 752 YLNGGFIIQWNGNYK--LAGTVFQY------DRKGDLEKLMATGPTNESVWIQLLFQ--- 800
+ G I N Y L +Y DR LE++ GP E IQ+ +
Sbjct: 573 VVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGE 632
Query: 801 ----VTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGR 856
+T P I + Y K +Q + W CSV+CG G+R C+ + R
Sbjct: 633 EYGNLTRPDITFTYFQPK-------PRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQAR 684
Query: 857 -GMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMV 915
+V+ C QP + C + CPP W G++ CSA+CG G ++R V C++
Sbjct: 685 KELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG-GGLRERPVRCVEAQG 743
Query: 916 SDEQALPPTDCQ-HLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKN 974
S + LPP C+ +P L CP+ W V S C+ + G G+ + + TC
Sbjct: 744 SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG 803
Query: 975 HDE-PCDVTRKPNS 987
D VT P S
Sbjct: 804 ADGLEAPVTEGPGS 817
Score = 90.9 bits (224), Expect = 9e-18
Identities = 52/149 (34%), Positives = 74/149 (49%), Gaps = 9/149 (6%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKK-----GRGMVKATFCDPETQPNGRQKKCHEKAC 882
WQY CSV+CG G+ R+ +C + G ++ T C +P Q+ C + C
Sbjct: 924 WQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPC 981
Query: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDI 942
PPRW CSA+CG G +R+V C+Q + + C L++P+ + C
Sbjct: 982 PPRWKVMSLGPCSASCGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC-LIA 1039
Query: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTC 971
C W VG W ECSVSCG G++ R TC
Sbjct: 1040 DCTYRWHVGTWMECSVSCGDGIQRRRDTC 1068
Score = 81.3 bits (199), Expect = 7e-15
Identities = 69/255 (27%), Positives = 95/255 (37%), Gaps = 32/255 (12%)
Query: 1303 SNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ------MDSDCAAIQRPDP 1356
S + + G +AH CS +CG G R C + C +P
Sbjct: 851 SPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGS 910
Query: 1357 AKR-CHLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRN----LRPFHCQFLAG 1410
+ C PC A W+ + CS +C G R + C + + L CQ G
Sbjct: 911 RREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQ---G 966
Query: 1411 IPPPLSM-SCNPEPCEA-WQVEPWSQCSRSCGGGVQERGVFC-----------PGGLCDW 1457
+P P +C+ EPC W+V CS SCG G R V C C
Sbjct: 967 LPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAA 1026
Query: 1458 TKRPTSTMSCNEHLCCH-WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDH 1516
RP +++ C C + W G W CS SCG G Q+R C+ + D C H
Sbjct: 1027 LVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPAD--FCQH 1084
Query: 1517 KPRPPEFKKCNQQAC 1531
P+P + C C
Sbjct: 1085 LPKPVTVRGCWAGPC 1099
Score = 79.3 bits (194), Expect = 3e-14
Identities = 54/179 (30%), Positives = 79/179 (44%), Gaps = 18/179 (10%)
Query: 833 WT----ECSVTCGTGIRRQTAHCIKKG-RGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
WT CSV+CG G+ C+ R V+ C ++P R++ C CP RW
Sbjct: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQ 925
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSD--EQALPPTDCQHLLKPKTLLSCNRDILCP 945
+ ACS +CG G +R + C + D E+ L T CQ L +P+ +C+ + CP
Sbjct: 926 Y-KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEP-CP 982
Query: 946 SDWTVGNWSECSVSCGGGVRIRSVTC--------AKNHDEPCDVTRKPNSRALCGLQQC 996
W V + CS SCG G RSV C + + C +P + C + C
Sbjct: 983 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1041
Score = 79.0 bits (193), Expect = 4e-14
Identities = 47/141 (33%), Positives = 68/141 (48%), Gaps = 13/141 (9%)
Query: 1325 CSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPA--KRCHLRPCAG-WKVGNWSK 1375
CS +CG G W C Q + C Q+P PA + C L PC W VG++
Sbjct: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQP-PAWPEACVLEPCPPYWAVGDFGP 722
Query: 1376 CSRNCSGGFKIREIQCVDSRDH--RNLRPFHCQFLAGIPPPLSMSCNPEPCEA-WQVEPW 1432
CS +C GG + R ++CV+++ + L P C+ A P +CNP+PC A W+V
Sbjct: 723 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 782
Query: 1433 SQCSRSCGGGVQERGVFCPGG 1453
S C+ + G G+ C G
Sbjct: 783 SSCTSAGGAGLALENETCVPG 803
Score = 64.3 bits (155), Expect = 9e-10
Identities = 69/273 (25%), Positives = 98/273 (35%), Gaps = 62/273 (22%)
Query: 1316 HWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDC-AAIQRPDPA-KRCHLRPC 1365
+W VG++ CS +CG G R V C T + C A Q+P A + C+ +PC
Sbjct: 714 YWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPC 773
Query: 1366 -AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFH-----CQFLAGIPPPLSMSC 1419
A W+V S C+ G + CV D + L P + MSC
Sbjct: 774 PARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSC 833
Query: 1420 NP-----EPCEAWQ--VEPW-----------------SQCSRSCGGGVQERGVFCPGG-- 1453
P + A + PW CS SCG G+ E C
Sbjct: 834 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSAL 893
Query: 1454 -------LCDWTKRPTSTMSCNEHLCCHWATGNWD----LCSTSCGGGFQKRTVQCVPSE 1502
LC +P S + + C W CS SCG G +R + C +
Sbjct: 894 RVPVQEELCGLASKPGSRREVCQAVPC---PARWQYKLAACSVSCGRGVVRRILYCARAH 950
Query: 1503 GNKTEDQDQCL----CDHKPRPPEFKKCNQQAC 1531
G +D ++ L C PRP + C+ + C
Sbjct: 951 GE--DDGEEILLDTQCQGLPRPEPQEACSLEPC 981
Score = 55.5 bits (132), Expect = 4e-07
Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 20/128 (15%)
Query: 1421 PEPCEAWQVEPWSQ----CSRSCGGGV---------QERGVFCPGGLCDWTKRPTS-TMS 1466
P+P +AW W+ CS SCG G+ Q R C +++P + +
Sbjct: 649 PKPRQAWV---WAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEA 705
Query: 1467 CNEHLCC-HWATGNWDLCSTSCGGGFQKRTVQCVPSEGN--KTEDQDQCLCDHKPRPPEF 1523
C C +WA G++ CS SCGGG ++R V+CV ++G+ KT +C +
Sbjct: 706 CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 765
Query: 1524 KKCNQQAC 1531
+ CN Q C
Sbjct: 766 ETCNPQPC 773
Score = 52.8 bits (125), Expect = 3e-06
Identities = 47/218 (21%), Positives = 78/218 (35%), Gaps = 48/218 (22%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPET--QPNGRQKKCHEKACPPR 885
W+ + C+ G G+ + C+ G+ P + + + C +CPP
Sbjct: 777 WEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG 836
Query: 886 W----------------------------WAGEWEACSATCGPHGEKKRTVLCIQTMVSD 917
W W +CS +CG G + LC+ + +
Sbjct: 837 WGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCG-RGLMELRFLCMDSALR- 894
Query: 918 EQALPPTD--CQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH 975
+P + C KP + + + CP+ W + CSVSCG GV R + CA+ H
Sbjct: 895 ---VPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAH 950
Query: 976 ----------DEPCDVTRKPNSRALCGLQQCPSSRRVL 1003
D C +P + C L+ CP +V+
Sbjct: 951 GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 988
Score = 42.4 bits (98), Expect = 0.004
Identities = 19/46 (41%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 826 YFWQYGHWTECSVTCGTGIRRQTAHCI-KKGRGMVKATFCDPETQP 870
Y W G W ECSV+CG GI+R+ C+ + + V A FC +P
Sbjct: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP 1088
Score = 41.6 bits (96), Expect = 0.006
Identities = 50/169 (29%), Positives = 66/169 (39%), Gaps = 19/169 (11%)
Query: 1348 CAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRP-FHCQ 1406
C ++ P H R + W G S CSR+C GG R QC N RP F +
Sbjct: 340 CRSLVELTPIAAVHGR-WSSW--GPRSPCSRSCGGGVVTRRRQC------NNPRPAFGGR 390
Query: 1407 FLAGIPPPLSMSCNPEPCEAWQVEPWS-QCSRSCGGGVQERGVFCPGGLCDWTKRPTSTM 1465
G M CN + CE Q+E S QC+R+ G ++ PGG +
Sbjct: 391 ACVGADLQAEM-CNTQACEKTQLEFMSQQCARTDGQPLRS----SPGGASFYHWGAAVPH 445
Query: 1466 SCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLC 1514
S + LC H + G F T +C+PS ED LC
Sbjct: 446 SQGDALCRHMCRAIGESFIMKRGDSFLDGT-RCMPS--GPREDGTLSLC 491
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 273 bits (697), Expect = 1e-72
Identities = 165/466 (35%), Positives = 232/466 (49%), Gaps = 53/466 (11%)
Query: 545 WGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFR 604
WG WS WS CSRTCG GV ER C + + + GG C G + +R C C A FR
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYS-QRRDGGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 605 QMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNS 664
QC+EFD ++ Y W P ++ + CEL C P F K +AV+DGTPC G
Sbjct: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPG--K 145
Query: 665 RNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPK 724
R+VC++G C++VGCD+E+DS+ ED+C C GDG++C V +G D + +
Sbjct: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPV---------AGTFDANDLSR 196
Query: 725 GARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDR--KGDL-- 780
+++R +YYLNG + I+ A T+ Y+R +GDL
Sbjct: 197 AVKNVR------------------GEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
Query: 781 EKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTC 840
E+L A GPT+E + I+L+ Q NPG+ YEY L + W +G W++CS C
Sbjct: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEY-----HLPLRRPSPGFSWSHGSWSDCSAEC 293
Query: 841 GTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACP--PRWWAGEWEACSATC 898
G G + + C C + +P R + C+ CP RW AG W CSA+C
Sbjct: 294 GGGHQSRLVFCTIDHEA-YPDHMCQRQPRPADR-RSCNLHPCPETKRWKAGPWAPCSASC 351
Query: 899 GPHGEKKRTVLCIQT-MVSDEQALPPTDCQHLL-KPKTLLSCNRDILCPSDWTVGNWSEC 956
G G + R+V CI + ++A+ +C L KP + +CN C + W+ W EC
Sbjct: 352 G-GGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQ-RCAA-WSPEPWGEC 408
Query: 957 SVSCGGGVRIRSVTCAKN-----HDEPCDVTRKPNSRALCGLQQCP 997
SVSCG GVR RSVTC H C + +P C + CP
Sbjct: 409 SVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCP 454
Score = 137 bits (344), Expect = 1e-31
Identities = 80/237 (33%), Positives = 101/237 (42%), Gaps = 28/237 (11%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM----DSDCAAIQRPDPAKRCHLRPCAG---WK 1369
W G+WS+CS CG G R V C+ D C RP + C+L PC WK
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWK 340
Query: 1370 VGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIP--PPLSMSCNPEPCEAW 1427
G W+ CS +C GG + R + C+ S AG+P PP +CN + C AW
Sbjct: 341 AGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAW 400
Query: 1428 QVEPWSQCSRSCGGGVQERGVFCPG--------GLCDWTKRPTSTMSCNEHLC-----CH 1474
EPW +CS SCG GV++R V C G C RP T C C
Sbjct: 401 SPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQA 460
Query: 1475 WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W G W LCS SC G ++R V C C +P + + CN Q C
Sbjct: 461 WHVGTWGLCSKSCSSGTRRRQVICA------IGPPSHCGSLQHSKPVDVEPCNTQPC 511
Score = 103 bits (257), Expect = 1e-21
Identities = 68/208 (32%), Positives = 91/208 (43%), Gaps = 30/208 (14%)
Query: 1352 QRPDPAKRC--HL---RPCAG--WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFH 1404
Q P+P HL RP G W G+WS CS C GG + R + C + DH
Sbjct: 258 QEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHM 315
Query: 1405 CQFLAGIPPPLSMSCNPEPC---EAWQVEPWSQCSRSCGGGVQERGVFC----PGGLCDW 1457
CQ P SCN PC + W+ PW+ CS SCGGG Q R V+C G+ +
Sbjct: 316 CQ--RQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEA 373
Query: 1458 TK---------RPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTED 1508
+ +P + +CN C W+ W CS SCG G +KR+V C G +
Sbjct: 374 VEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTC---RGERGSL 430
Query: 1509 QDQCLCDHKPRPPEFKKCNQQACKKSAD 1536
C + RPP + C + C +D
Sbjct: 431 LHTAACSLEDRPPLTEPCVHEDCPLLSD 458
Score = 67.4 bits (163), Expect = 1e-10
Identities = 43/138 (31%), Positives = 54/138 (39%), Gaps = 16/138 (11%)
Query: 1307 QLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDS-----DCAAIQRPDPAKRCH 1361
Q N A W W ECS +CG+G R V C + S C+ RP + C
Sbjct: 390 QACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449
Query: 1362 LRPC-----AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLS 1416
C W VG W CS++CS G + R++ C P HC L P
Sbjct: 450 HEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIG------PPSHCGSLQHSKPVDV 503
Query: 1417 MSCNPEPCEAWQVEPWSQ 1434
CN +PC Q P Q
Sbjct: 504 EPCNTQPCHLPQEVPSMQ 521
Score = 53.1 bits (126), Expect = 2e-06
Identities = 23/58 (39%), Positives = 31/58 (53%), Gaps = 4/58 (6%)
Query: 948 WTVGNWSECSVSCGGGVRIRSVTCAKNH----DEPCDVTRKPNSRALCGLQQCPSSRR 1001
W+ G+WS+CS CGGG + R V C +H D C +P R C L CP ++R
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKR 338
Score = 36.2 bits (82), Expect = 0.26
Identities = 21/58 (36%), Positives = 25/58 (43%), Gaps = 4/58 (6%)
Query: 542 PG-GWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERK--RYRLCNVHPC 596
PG W S WS CS CG G QS C + C + + R CN+HPC
Sbjct: 277 PGFSWSHGS-WSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPC 333
Score = 33.9 bits (76), Expect = 1.3
Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 11/85 (12%)
Query: 1432 WSQCSRSCGGGVQERGVFC------PGGLCDWTKRPTSTMSCNEHLCCHWATG-NWDLCS 1484
WS CSR+CGGGV R C G C R S SC C A + C+
Sbjct: 35 WSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPAR--SHRSCRTESCPDGARDFRAEQCA 92
Query: 1485 TSCGGGFQKRTVQCVP--SEGNKTE 1507
G FQ R + +P S NK E
Sbjct: 93 EFDGAEFQGRRYRWLPYYSAPNKCE 117
Score = 32.0 bits (71), Expect = 4.9
Identities = 12/23 (52%), Positives = 12/23 (52%)
Query: 1373 WSKCSRNCSGGFKIREIQCVDSR 1395
WS CSR C GG RE C R
Sbjct: 35 WSPCSRTCGGGVSFRERPCYSQR 57
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 229 bits (585), Expect = 1e-59
Identities = 145/469 (30%), Positives = 218/469 (46%), Gaps = 53/469 (11%)
Query: 536 KKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHP 595
+ E G W W WS CSRTCG G + R C G+ C G+ RY+ C+ H
Sbjct: 69 RSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNHD 122
Query: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFN-PAHPCELYCRPIDGQFSEKMLDAVID 654
C +A FR QCS ++ V Y+ Y W P +N PA PC L C ++ V+D
Sbjct: 123 CPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLD 182
Query: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQ--KE 712
GT C +S ++CI+GIC+ VGCD ++ SNA ED CGVC GDGS+C+ VR K
Sbjct: 183 GTRC--NTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
Query: 713 GSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVF 772
++ +P G+R +R+ A F+ ++ K G G + + T
Sbjct: 241 EKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSK----GEHSFNSPGVFLVENTTV 296
Query: 773 QYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQ--MYFWQY 830
++ R + + GP + +F K YT KD + Q + W+
Sbjct: 297 EFQRGSERQTFKIPGP----LMADFIF-------KTRYTAAKDSVVQFFFYQPISHQWRQ 345
Query: 831 GHWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCD--PE-TQPNGRQKKCHEKACP--- 883
+ C+VTCG G + +A C+ + + +V +C PE +P + K+C CP
Sbjct: 346 TDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSD 405
Query: 884 --------------PRWWAGEWEACSATCGPHGEKKRTVLCI-QTMVSDEQALPPTDCQH 928
PRW W ACS +CG G ++R+ +C+ ++M + + C +
Sbjct: 406 GFKEIMPYDHFQPLPRWEHNPWTACSVSCG-GGIQRRSFVCVEESMHGEILQVEEWKCMY 464
Query: 929 LLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE 977
KPK + +CN CP W WS+C+V+CG G+R R V C + E
Sbjct: 465 APKPKVMQTCNL-FDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGE 511
Score = 127 bits (318), Expect = 1e-28
Identities = 84/275 (30%), Positives = 126/275 (45%), Gaps = 30/275 (10%)
Query: 1317 WIVGNWSECSTTCG-LGAYWRRVECSTQMDSD-----CAAIQRPDPA-KRCHLRPC-AGW 1368
W GNWS CS TCG LGA +R +C + C +Q+P + C++R C A W
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
Query: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMS-CNPEPCEAW 1427
WS+CS +C G+ R++ C ++ + ++ + A PL C PC W
Sbjct: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQW 1547
Query: 1428 QVEPWSQCSRSCGGG---VQERGVFCPGGL----CDWTKRPTSTMSCNEHLC--CHWATG 1478
EP ++C C G +Q+R C CD KRPT +C C C W TG
Sbjct: 1548 --EPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVC-WHTG 1604
Query: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLL 1538
W C+ +CG GFQ R V C+ + K + C+ K +P ++ C +C +
Sbjct: 1605 PWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCV--QKKKPISWRHCLGPSCDRD---- 1658
Query: 1539 CTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQ 1573
CT + +C +K + CS+ + CC SC +
Sbjct: 1659 CTD---TTHYCMFVKHLNLCSLDRYKQRCCQSCQE 1690
Score = 111 bits (278), Expect = 5e-24
Identities = 67/198 (33%), Positives = 94/198 (47%), Gaps = 17/198 (8%)
Query: 826 YFWQYGHWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
Y W+Y +T C+ TC G + A C+ + + V + CD +P + C+ + CPP
Sbjct: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
Query: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILC 944
RW G W CSATCG G + R V C+ E PP +C+ KP L +CN+ C
Sbjct: 706 RWHVGSWGPCSATCGV-GIQTRDVYCLH---PGETPAPPEECRD-EKPHALQACNQ-FDC 759
Query: 945 PSDWTVGNWSECSVSCGGGVRIRSVTCAK---------NHDEPCDVTRKPNSRALCGLQQ 995
P W + W +CS +CGGG + R VTC + DE C K +S C
Sbjct: 760 PPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ-GPKASSHKSCARTD 818
Query: 996 CPSSRRVLKPNKGTISNG 1013
CP V +K ++S G
Sbjct: 819 CPPHLAVGDWSKCSVSCG 836
Score = 110 bits (274), Expect = 1e-23
Identities = 74/248 (29%), Positives = 102/248 (41%), Gaps = 28/248 (11%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVEC------STQMDSDCAAIQRPDP-AKRCHLRPCAG-W 1368
W ++ C+ TC G C T DS C + RP ++ C+ PC W
Sbjct: 648 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRW 707
Query: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE-AW 1427
VG+W CS C G + R++ C+ H P + P +CN C W
Sbjct: 708 HVGSWGPCSATCGVGIQTRDVYCL----HPGETPAPPEECRDEKPHALQACNQFDCPPGW 763
Query: 1428 QVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSC-----NEHLCC-------HW 1475
+E W QCSR+CGGG Q R V C L D + S C + H C H
Sbjct: 764 HIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHL 823
Query: 1476 ATGNWDLCSTSCGGGFQKRTVQC--VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533
A G+W CS SCG G Q+R C + ++G + + +C P P + C C K
Sbjct: 824 AVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRI-PLSEMMCRDLPGLPLVRSCQMPECSK 882
Query: 1534 SADLLCTK 1541
+ TK
Sbjct: 883 IKSEMKTK 890
Score = 97.1 bits (240), Expect = 1e-19
Identities = 56/153 (36%), Positives = 73/153 (47%), Gaps = 18/153 (11%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W G W CS TCG GI+ + +C+ G C E +P+ Q C++ CPP W
Sbjct: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQA-CNQFDCPPGWH 764
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTM-------VSDEQALPPTDCQHLLKPKTLLSCNR 940
EW+ CS TCG G + R V C Q + +SDE P H SC R
Sbjct: 765 IEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHK-------SCAR 816
Query: 941 DILCPSDWTVGNWSECSVSCGGGVRIRSVTCAK 973
CP VG+WS+CSVSCG G++ R C +
Sbjct: 817 TD-CPPHLAVGDWSKCSVSCGVGIQRRKQVCQR 848
Score = 85.1 bits (209), Expect = 5e-16
Identities = 44/168 (26%), Positives = 68/168 (40%), Gaps = 32/168 (19%)
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGI--PPPLSMSCNPEPCE 1425
W+ ++ C+ C GG+++ +CVD R R + +C + P P C+ +PC
Sbjct: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
Query: 1426 A------------------WQVEPWSQCSRSCGGGVQERGVFC------------PGGLC 1455
+ W+ PW+ CS SCGGG+Q R C C
Sbjct: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
Query: 1456 DWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEG 1503
+ +P +CN C W W C+ +CG G + R V C+ G
Sbjct: 463 MYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRG 510
Score = 80.5 bits (197), Expect = 1e-14
Identities = 69/284 (24%), Positives = 99/284 (34%), Gaps = 71/284 (25%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM---------DSDCAAIQRPDPAKRCHLRPCAG 1367
W W+ CS +CG G R C + + C +P + C+L C
Sbjct: 422 WEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPK 481
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHR--NLRP---FHCQFLAGIPPPLSMSCNPE 1422
W WS+C+ C G + R + C++ R P H + IP P
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
Query: 1423 PCEA----------------------WQVEPWSQCSRSCGGGVQERGVFC---------- 1450
P EA + EPWS CS +CG GVQ R V C
Sbjct: 542 PVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTE 601
Query: 1451 ---PGGLCDW----TKRPTSTMSCNE---------------HLCCHWATGNWDLCSTSCG 1488
P C+ T+RP +C+E W + C+ +C
Sbjct: 602 TELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCV 661
Query: 1489 GGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKK-CNQQAC 1531
GG Q+ C+ + +T + LCD RPP + CN + C
Sbjct: 662 GGHQEAIAVCLHIQTQQTVNDS--LCDMVHRPPAMSQACNTEPC 703
Score = 80.1 bits (196), Expect = 2e-14
Identities = 55/176 (31%), Positives = 72/176 (40%), Gaps = 11/176 (6%)
Query: 827 FWQYGHWTECSVTCG-TGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPR 885
FW+ G+W+ CS TCG G R Q C+ V CD +P + C+ + CP R
Sbjct: 1427 FWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPAR 1486
Query: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE-QALPPTDCQHLLKPKTLLSCNRDILC 944
W+ W CS +CG G R V C +T + Q + P C +P C
Sbjct: 1487 WFTSVWSQCSVSCG-EGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCV 1545
Query: 945 PSDWTVGNWSECSVSC-GGGVRI--RSVTCAKN-HDEPCDVTRKPNSRALCGLQQC 996
W GN C C G VR+ R C N D CD ++P R C C
Sbjct: 1546 --QWEPGN--RCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGAC 1597
Score = 73.9 bits (180), Expect = 1e-12
Identities = 64/231 (27%), Positives = 96/231 (41%), Gaps = 46/231 (19%)
Query: 814 KDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRG----MVKATFCDPETQ 869
K+ + D Q + W++ WT CSV+CG GI+R++ C+++ V+ C +
Sbjct: 408 KEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPK 467
Query: 870 PNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQ-------------TMVS 916
P Q C+ CP +W A EW C+ TCG G + R VLCI +
Sbjct: 468 PKVMQT-CNLFDCP-KWIAMEWSQCTVTCG-RGLRYRVVLCINHRGEHVGGCNPQLKLHI 524
Query: 917 DEQALPPTDCQH------------LLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGV 964
E+ + P C LK L R + WS CS +CG GV
Sbjct: 525 KEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGV 584
Query: 965 RIRSVTC----------AKNHDEPCDVTRKPNSRALCGLQQC---PSSRRV 1002
++R V C + +E C+ + P R C L+ C P+SR +
Sbjct: 585 QVREVKCRVLLTFTQTETELPEEECEGPKLPTERP-CLLEACDESPASREL 634
Score = 72.0 bits (175), Expect = 4e-12
Identities = 72/294 (24%), Positives = 105/294 (35%), Gaps = 78/294 (26%)
Query: 1314 SAHWIVGNWSECSTTCGLGAYWRRVEC------STQMDSDCAAIQ---RPDP-AKRCHLR 1363
S W ++ C+ TCG G EC D C +P P K C +
Sbjct: 340 SHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMD 399
Query: 1364 PCAG------------------WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNL---RP 1402
PC W+ W+ CS +C GG + R CV+ H +
Sbjct: 400 PCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEE 459
Query: 1403 FHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPG------GLCD 1456
+ C + P + +CN C W WSQC+ +CG G++ R V C G C+
Sbjct: 460 WKCMYAP--KPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCN 517
Query: 1457 WTKRPTSTMSCNEHLCCH-------------W------------ATGN-------WDLCS 1484
+ C + C+ W AT W CS
Sbjct: 518 PQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACS 577
Query: 1485 TSCGGGFQKRTVQC-VPSEGNKTE---DQDQCLCDHKPRPPEFKKCNQQACKKS 1534
T+CG G Q R V+C V +TE +++C P+ P + C +AC +S
Sbjct: 578 TTCGPGVQVREVKCRVLLTFTQTETELPEEEC---EGPKLPTERPCLLEACDES 628
Score = 69.7 bits (169), Expect = 2e-11
Identities = 38/92 (41%), Positives = 48/92 (52%), Gaps = 7/92 (7%)
Query: 884 PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKT-LLSCN-RD 941
P W G W CSATCG G + + C+ +++ Q + C HL KP CN RD
Sbjct: 1426 PFWEPGNWSHCSATCGHLGARIQRPQCV---MANGQEVSEALCDHLQKPLAGFEPCNIRD 1482
Query: 942 ILCPSDWTVGNWSECSVSCGGGVRIRSVTCAK 973
CP+ W WS+CSVSCG G R VTC +
Sbjct: 1483 --CPARWFTSVWSQCSVSCGEGYHSRQVTCKR 1512
Score = 67.4 bits (163), Expect = 1e-10
Identities = 52/198 (26%), Positives = 75/198 (37%), Gaps = 43/198 (21%)
Query: 833 WTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQ-PNGR--------QKKCHEKACP 883
W+ CS TCG G++ + C V TF ET+ P ++ C +AC
Sbjct: 573 WSACSTTCGPGVQVREVKC------RVLLTFTQTETELPEEECEGPKLPTERPCLLEACD 626
Query: 884 PR-------------------WWAGEWEACSATC-GPHGEKKRTVLCIQTMVSDEQALPP 923
W + C+ATC G H E L IQT +Q +
Sbjct: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQT----QQTVND 682
Query: 924 TDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDV-- 981
+ C + +P + CP W VG+W CS +CG G++ R V C + P
Sbjct: 683 SLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEE 742
Query: 982 --TRKPNSRALCGLQQCP 997
KP++ C CP
Sbjct: 743 CRDEKPHALQACNQFDCP 760
Score = 38.5 bits (88), Expect = 0.052
Identities = 20/58 (34%), Positives = 29/58 (50%), Gaps = 10/58 (17%)
Query: 1293 LITEGFLLN----------ASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVEC 1340
L+T+G LN AS++K H VG+WS+CS +CG+G R+ C
Sbjct: 789 LLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
Score = 34.7 bits (78), Expect = 0.76
Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 8/64 (12%)
Query: 550 PWSHCSRTCGAGVQSAERLC------NNPEPKFGGKYCTGER-KRYRLCNVHPCRSEAPT 602
PWS CS TCG GVQ E C E + + C G + R C + C E+P
Sbjct: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEAC-DESPA 630
Query: 603 FRQM 606
R++
Sbjct: 631 SREL 634
Score = 34.7 bits (78), Expect = 0.76
Identities = 26/79 (32%), Positives = 32/79 (40%), Gaps = 20/79 (25%)
Query: 539 ESIPGGW--GRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC 596
E P W G W P CS TCG G+Q+ + C +P GE C
Sbjct: 701 EPCPPRWHVGSWGP---CSATCGVGIQTRDVYCLHP----------GETP----APPEEC 743
Query: 597 RSEAPTFRQMQCSEFDTVP 615
R E P Q C++FD P
Sbjct: 744 RDEKPHALQ-ACNQFDCPP 761
Score = 34.3 bits (77), Expect = 0.99
Identities = 16/62 (25%), Positives = 27/62 (43%)
Query: 1476 ATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
A G+W CS +CGGG +C+ + ++ C + PP+ + Q C
Sbjct: 80 AWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYN 139
Query: 1536 DL 1537
D+
Sbjct: 140 DV 141
Score = 33.5 bits (75), Expect = 1.7
Identities = 21/77 (27%), Positives = 29/77 (37%), Gaps = 7/77 (9%)
Query: 1306 KQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVEC-STQMDSDCAAIQRPDPAKRCHLRP 1364
+ T+G W G W C+ CG G R+V+C T+ A K R
Sbjct: 1590 RNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRH 1649
Query: 1365 CAGWKVGNWSKCSRNCS 1381
C G C R+C+
Sbjct: 1650 CLG------PSCDRDCT 1660
Score = 32.7 bits (73), Expect = 2.9
Identities = 22/78 (28%), Positives = 30/78 (38%), Gaps = 25/78 (32%)
Query: 548 WSP--WSHCSRTCG--------------AGVQSAERLCNNPEPKFGGKYCTGERKRYRLC 591
W P WSHCS TCG G + +E LC++ + G + C
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAG---------FEPC 1478
Query: 592 NVHPCRSEAPTFRQMQCS 609
N+ C + T QCS
Sbjct: 1479 NIRDCPARWFTSVWSQCS 1496
Score = 32.0 bits (71), Expect = 4.9
Identities = 13/28 (46%), Positives = 14/28 (50%), Gaps = 1/28 (3%)
Query: 542 PGGWGRWSPWSHCSRTCGAGVQSAERLC 569
P GW W CSRTCG G Q+ C
Sbjct: 760 PPGW-HIEEWQQCSRTCGGGTQNRRVTC 786
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 214 bits (546), Expect = 4e-55
Identities = 145/485 (29%), Positives = 223/485 (45%), Gaps = 54/485 (11%)
Query: 536 KKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHP 595
+ E G W W PWS CSRTCG G + R C K C G RYR C+
Sbjct: 27 RSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVD 80
Query: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFN-PAHPCELYCRPIDGQFSEKMLDAVID 654
C EA FR QCS + V + + Y W P+ N P +PC L C+ ++ V+D
Sbjct: 81 CPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS 714
GT C+ S ++CI+G+C++VGCD+++ S ED CGVC GDGS+C+ VR +K + +
Sbjct: 141 GTRCYT--ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSA 198
Query: 715 GYVD--IGLIPKGARDIRVMEIEGAGN-FLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTV 771
D + IP G+R IR++ ++G + +L ++ K G + G + + +
Sbjct: 199 TKSDDTVVAIPYGSRHIRLV-LKGPDHLYLETKTLQGTK----GENSLSSTGTFLVDNSS 253
Query: 772 FQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYG 831
+ + D E L GP + + ++ N G + T+Q + + W+
Sbjct: 254 VDFQKFPDKEILRMAGP----LTADFIVKIRNSG-SADSTVQFIFYQPIIHR----WRET 304
Query: 832 HWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCD--PET-QPNGRQKKCHEKACP---- 883
+ CS TCG G + +A C + +V +C PE +P + ++C+ CP
Sbjct: 305 DFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDG 364
Query: 884 -------------PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE-QALPPTDCQHL 929
PRW A W ACS++CG G + R V C++ + ++ C +
Sbjct: 365 YKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYT 423
Query: 930 LKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKN---HDEPCDVTRKPN 986
K CN CP W WS C+V+CG G+R R V C + H C KP+
Sbjct: 424 PKMPIAQPCN-IFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPH 481
Query: 987 SRALC 991
+ C
Sbjct: 482 IKEEC 486
Score = 137 bits (345), Expect = 8e-32
Identities = 86/277 (31%), Positives = 126/277 (45%), Gaps = 30/277 (10%)
Query: 1317 WIVGNWSECSTTCG-LGAYWRRVEC---STQMD-SDCAAIQRPDPAK-RCHLRPCAG-WK 1369
W V + CS +CG G R+ C ST+++ + CA RP C+ R C W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 1370 VGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIP--PPLSMSCNPEPCEAW 1427
V +WS C+R+C GG + R + C + P + P + +CN + C W
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEW 1610
Query: 1428 QVEPWSQCSRSCGG---GVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLCC-HW 1475
W QC+ C G VQ R VFC P C RP ST +C C HW
Sbjct: 1611 AFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHW 1670
Query: 1476 ATGNWDLCSTSCGG-GFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKS 1534
W LC+ +CG GFQ R V+CV + NK + LC PRP +++CN C+
Sbjct: 1671 RVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEH--LCSWGPRPANWQRCNITPCE-- 1726
Query: 1535 ADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
++ C + +C+ +K +K C + ++ CC +C
Sbjct: 1727 -NMECRD---TTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 108 bits (271), Expect = 3e-23
Identities = 79/269 (29%), Positives = 113/269 (42%), Gaps = 43/269 (15%)
Query: 813 QKDGLDNDVEQ--QMYFWQYGHWTECSVTCGTGIRRQTAHCI-KKGRGMVKATFCDPETQ 869
+ DGL ++ ++Y W+Y +T+CS +CG G++ C+ K+ R + C +
Sbjct: 594 ETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRR 653
Query: 870 PNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLC--IQTMVSDEQALPPTDCQ 927
P K C+ CP RW G+W CS TCG G + R V C + + +E + +
Sbjct: 654 PPQLLKSCNLDPCPARWEIGKWSPCSLTCGV-GLQTRDVFCSHLLSREMNETVILADELC 712
Query: 928 HLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH--------DEPC 979
KP T+ +CNR CP W W CS +CGGGV+ R V C + E
Sbjct: 713 RQPKPSTVQACNR-FNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETF 771
Query: 980 DVTRKPNSRALCGLQQCPSS------------------------RRVLKPNKGTISNGKN 1015
KP + C CPS R++LK T+ N
Sbjct: 772 CSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTL 831
Query: 1016 PPTLKPVPPPTS-RPRMLTTPTGPESMST 1043
P P+P +S RP ML T P ST
Sbjct: 832 CP---PLPFSSSIRPCMLATCARPGRPST 857
Score = 105 bits (263), Expect = 3e-22
Identities = 71/242 (29%), Positives = 100/242 (41%), Gaps = 26/242 (10%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPA-KRCHLRPC-AGW 1368
W +++CS +CG G V C + + C +RP K C+L PC A W
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARW 670
Query: 1369 KVGNWSKCSRNCSGGFKIREIQCVD--SRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE- 1425
++G WS CS C G + R++ C SR+ + P +CN C
Sbjct: 671 EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP 730
Query: 1426 AWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWT-----------KRPTSTMSCNEHLC-C 1473
AW W CSR+CGGGVQ+R V C + D + +P +C + C
Sbjct: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPS 790
Query: 1474 HWATGNWDLCSTSCGGGFQKRTVQC--VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W +W CSTSCG G Q R+ C + G T + LC P + C C
Sbjct: 791 EWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTV-VNSTLCPPLPFSSSIRPCMLATC 849
Query: 1532 KK 1533
+
Sbjct: 850 AR 851
Score = 94.0 bits (232), Expect = 1e-18
Identities = 57/210 (27%), Positives = 83/210 (39%), Gaps = 38/210 (18%)
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGI--PPPLSMSCNPEPCE 1425
W+ ++ CS C GG+++ +C D R +R + +C + P P CN +PC
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1426 A------------------WQVEPWSQCSRSCGGGVQERGVFC------------PGGLC 1455
A W+ PW+ CS SCGGG+Q R V C C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 1456 DWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCD 1515
+T + CN C W W C+ +CG G + R V C+ G T C
Sbjct: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG-----CS 475
Query: 1516 HKPRPPEFKKC-NQQACKKSADLLCTKDKL 1544
K +P ++C C K + L + KL
Sbjct: 476 PKTKPHIKEECIVPTPCYKPKEKLPVEAKL 505
Score = 86.7 bits (213), Expect = 2e-16
Identities = 44/148 (29%), Positives = 61/148 (41%), Gaps = 12/148 (8%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQMD----------SDCAAIQRPDPAKRCHLRP 1364
A W +G WS CS TCG+G R V CS + + +P + C+
Sbjct: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFN 727
Query: 1365 C-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
C W W CSR C GG + RE+ C + F + P +C +
Sbjct: 728 CPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
Query: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFC 1450
C + W + W++CS SCG G Q R C
Sbjct: 788 CPSEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 86.7 bits (213), Expect = 2e-16
Identities = 57/183 (31%), Positives = 85/183 (46%), Gaps = 29/183 (15%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSD-CAAI-QRPDPAKRCHLRP 1364
+ W+V +WS C+ +CG G RRV C ST + +D C + +RP + C+ +
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 1365 CAGWKVGNWSKCSRNCSG---GFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLS-MSCN 1420
C W +W +C+ C G + R++ C +RD L C + +P P+S +C
Sbjct: 1607 CVEWAFSSWGQCNGPCIGPHLAVQHRQVFC-QTRDGITLPSEQC---SALPRPVSTQNCW 1662
Query: 1421 PEPCEA-WQVEPWSQCSRSCGG-GVQERGVFC---------PGGLCDWTKRPTSTMSCNE 1469
E C W+V W+ C+ +CG G Q R V C P LC W RP + CN
Sbjct: 1663 SEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI 1722
Query: 1470 HLC 1472
C
Sbjct: 1723 TPC 1725
Score = 80.1 bits (196), Expect = 2e-14
Identities = 68/299 (22%), Positives = 100/299 (33%), Gaps = 86/299 (28%)
Query: 1312 HGSAHWIVGNWSECSTTCGLGAYWRRVEC---------STQMDSDCAAIQRPDPAKRCHL 1362
H W W+ CS++CG G R V C ++ + C + A+ C++
Sbjct: 375 HPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNI 434
Query: 1363 RPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC-NP 1421
C W WS C+ C G + R + C+ DHR + C P + C P
Sbjct: 435 FDCPKWLAQEWSPCTVTCGQGLRYRVVLCI---DHRGMHTGGCS--PKTKPHIKEECIVP 489
Query: 1422 EPC-------------------------------EAWQVEPWSQCSRSCGGGVQERGVFC 1450
PC ++ E WS C+ +CG G Q R V C
Sbjct: 490 TPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRC 549
Query: 1451 -------------PGGLCDWTKRPTSTMSCNEHLCC------------------------ 1473
P C+ K P S +C C
Sbjct: 550 QVLLSFSQSVADLPIDECEGPK-PASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDEL 608
Query: 1474 -HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W + CS SCGGG Q+ V C+ + + +++ C+ +P P K CN C
Sbjct: 609 YDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRP-PQLLKSCNLDPC 666
Score = 72.8 bits (177), Expect = 3e-12
Identities = 68/292 (23%), Positives = 101/292 (34%), Gaps = 83/292 (28%)
Query: 1318 IVGNWSE-----CSTTCGLGAYWRRVECSTQMDSDCAAIQ---------RPDP-AKRCHL 1362
I+ W E CS TCG G EC + A Q +P P + C+L
Sbjct: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
Query: 1363 RPCAG------------------WKVGNWSKCSRNCSGGFKIREIQCV--DSRDH-RNLR 1401
PC W+ W+ CS +C GG + R + CV D + H ++
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 1402 PFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFC------PGGLC 1455
+ C + + P++ CN C W + WS C+ +CG G++ R V C G C
Sbjct: 417 EWKCMYTPKM--PIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 1456 DWTKRPTSTMSCNEHLCCH--------------------------------WATGNWDLC 1483
+P C C+ + W C
Sbjct: 475 SPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSAC 534
Query: 1484 STSCGGGFQKRTVQC--VPSEGNKTEDQ--DQCLCDHKPRPPEFKKCNQQAC 1531
+ +CG G Q R V+C + S D D+C P+P + C C
Sbjct: 535 TVTCGVGTQVRIVRCQVLLSFSQSVADLPIDEC---EGPKPASQRACYAGPC 583
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/190 (27%), Positives = 77/190 (40%), Gaps = 15/190 (7%)
Query: 824 QMYFWQYGHWTECSVTCGT-GIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKAC 882
Q Y+W CS +CG G+++ C+ V C + +P + C+ + C
Sbjct: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE-VNPAHCAGKVRPAVQPIACNRRDC 1545
Query: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD-CQHLLK-PKTLLSCNR 940
P RW W AC+ +CG G + R V C + S D C + K P +CN+
Sbjct: 1546 PSRWMVTSWSACTRSCG-GGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
Query: 941 DILCPSDWTVGNWSECSVSCGG---GVRIRSVTCAKNH-----DEPCDVTRKPNSRALCG 992
LC +W +W +C+ C G V+ R V C E C +P S C
Sbjct: 1605 Q-LC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCW 1662
Query: 993 LQQCPSSRRV 1002
+ C RV
Sbjct: 1663 SEACSVHWRV 1672
Score = 63.9 bits (154), Expect = 1e-09
Identities = 48/182 (26%), Positives = 73/182 (40%), Gaps = 18/182 (9%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCDPETQPNGRQ---KKCHEKACP 883
W W+ C+ +CG G++ + C K K G+ D TQ R + C+++ C
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 884 PRWWAGEWEACSATC-GPH-GEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRD 941
W W C+ C GPH + R V C D LP C L +P + +C +
Sbjct: 1609 -EWAFSSWGQCNGPCIGPHLAVQHRQVFC---QTRDGITLPSEQCSALPRPVSTQNCWSE 1664
Query: 942 ILCPSDWTVGNWSECSVSCGG-GVRIRSVTCAKNH------DEPCDVTRKPNSRALCGLQ 994
C W V W+ C+ +CG G + R V C + C +P + C +
Sbjct: 1665 A-CSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
Query: 995 QC 996
C
Sbjct: 1724 PC 1725
Score = 63.5 bits (153), Expect = 2e-09
Identities = 56/205 (27%), Positives = 83/205 (40%), Gaps = 46/205 (22%)
Query: 833 WTECSVTCGTGIRRQTAHC---IKKGRGMVKATFCDPETQPNGRQKKCHEKACP---PRW 886
W+ C+VTCG G + + C + + + + E Q+ C+ C P +
Sbjct: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEF 590
Query: 887 WAGE----------------WE-----ACSATCGPHGEKKRTVLCI--QTMVSDEQALPP 923
E WE CS +CG G ++ V C+ QT E+ L
Sbjct: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVVSCLNKQTREPAEENLCV 649
Query: 924 TDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAK---------- 973
T + P+ L SCN D CP+ W +G WS CS++CG G++ R V C+
Sbjct: 650 TSRR---PPQLLKSCNLDP-CPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETV 705
Query: 974 -NHDEPCDVTRKPNSRALCGLQQCP 997
DE C KP++ C CP
Sbjct: 706 ILADELCR-QPKPSTVQACNRFNCP 729
Score = 60.8 bits (146), Expect = 1e-08
Identities = 36/129 (27%), Positives = 56/129 (43%), Gaps = 12/129 (9%)
Query: 1307 QLTNGHGSAHWIVGNWSECSTTC---GLGAYWRRVECSTQ-----MDSDCAAIQRPDPAK 1358
Q N W +W +C+ C L R+V C T+ C+A+ RP +
Sbjct: 1600 QACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQ 1659
Query: 1359 RCHLRPCA-GWKVGNWSKCSRNCSG-GFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLS 1416
C C+ W+V W+ C+ C GF+ R ++CV +R ++ + C + G P
Sbjct: 1660 NCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSW--GPRPANW 1717
Query: 1417 MSCNPEPCE 1425
CN PCE
Sbjct: 1718 QRCNITPCE 1726
Score = 38.1 bits (87), Expect = 0.069
Identities = 49/196 (25%), Positives = 76/196 (38%), Gaps = 40/196 (20%)
Query: 531 CITVGKKPESI--------PGGW--GRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKY 580
C+T + P+ + P W G+WSP CS TCG G+Q+ + C++
Sbjct: 648 CVTSRRPPQLLKSCNLDPCPARWEIGKWSP---CSLTCGVGLQTRDVFCSH--------L 696
Query: 581 CTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYC--- 637
+ E + CR P+ Q C+ F+ P W+P PC C
Sbjct: 697 LSREMNETVILADELCRQPKPSTVQ-ACNRFNCPP------AWYPA--QWQPCSRTCGGG 747
Query: 638 -RPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYE-IDSNATEDRCGVCL 695
+ + ++M D P S+ C CK C E + S+ TE C
Sbjct: 748 VQKREVLCKQRMADGSFLELPETFCSASKPAC-QQACKKDDCPSEWLLSDWTE--CSTSC 804
Query: 696 GDGSSCQTV--RKMFK 709
G+G+ ++ RKM K
Sbjct: 805 GEGTQTRSAICRKMLK 820
Score = 36.2 bits (82), Expect = 0.26
Identities = 19/61 (31%), Positives = 29/61 (47%), Gaps = 9/61 (14%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSD-CAAIQRPDPAKRCHLRPC 1365
+ W++ +W+ECST+CG G R C ST ++S C + + C L C
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
Query: 1366 A 1366
A
Sbjct: 850 A 850
Score = 35.0 bits (79), Expect = 0.58
Identities = 35/135 (25%), Positives = 54/135 (40%), Gaps = 25/135 (18%)
Query: 496 CQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIP-------GG---- 544
CQ L + +D +G + ++ C AG C G+ PE P GG
Sbjct: 549 CQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCS--GEIPEFNPDETDGLFGGLQDF 605
Query: 545 -----WGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGK--YCTGERKRYRL---CNVH 594
W + ++ CS +CG GVQ A C N + + + C R+ +L CN+
Sbjct: 606 DELYDW-EYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLD 664
Query: 595 PCRSEAPTFRQMQCS 609
PC + + CS
Sbjct: 665 PCPARWEIGKWSPCS 679
Score = 34.7 bits (78), Expect = 0.76
Identities = 18/62 (29%), Positives = 26/62 (41%)
Query: 1476 ATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
A G W CS +CGGG +C+ S+ + + C + PPE Q C
Sbjct: 38 AWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHN 97
Query: 1536 DL 1537
D+
Sbjct: 98 DV 99
Score = 32.7 bits (73), Expect = 2.9
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 11/54 (20%)
Query: 1371 GNWSKCSRNCSGGFKIREIQCVDSR--DHRNLRPFHCQFLAGIPPPLSMSCNPE 1422
G WS+CSR C GG +C+ S+ + RN+R C ++ C PE
Sbjct: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCS---------NVDCPPE 84
Score = 32.3 bits (72), Expect = 3.8
Identities = 12/18 (66%), Positives = 15/18 (83%), Gaps = 2/18 (11%)
Query: 1425 EAWQVEPWSQCSRSCGGG 1442
+AW PWS+CSR+CGGG
Sbjct: 37 DAWG--PWSECSRTCGGG 52
Score = 31.6 bits (70), Expect = 6.4
Identities = 27/98 (27%), Positives = 35/98 (35%), Gaps = 14/98 (14%)
Query: 534 VGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLC------NNPEPKFGGKYCTGER-K 586
V ++P IP WS C+ TCG G Q C + C G +
Sbjct: 520 VSEEPSFIP------EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPA 573
Query: 587 RYRLCNVHPCRSEAPTFRQMQCSE-FDTVPYKNELYHW 623
R C PC E P F + F + +ELY W
Sbjct: 574 SQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDW 611
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 214 bits (546), Expect = 4e-55
Identities = 145/485 (29%), Positives = 223/485 (45%), Gaps = 54/485 (11%)
Query: 536 KKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHP 595
+ E G W W PWS CSRTCG G + R C K C G RYR C+
Sbjct: 27 RSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVD 80
Query: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFN-PAHPCELYCRPIDGQFSEKMLDAVID 654
C EA FR QCS + V + + Y W P+ N P +PC L C+ ++ V+D
Sbjct: 81 CPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS 714
GT C+ S ++CI+G+C++VGCD+++ S ED CGVC GDGS+C+ VR +K + +
Sbjct: 141 GTRCYT--ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSA 198
Query: 715 GYVD--IGLIPKGARDIRVMEIEGAGN-FLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTV 771
D + IP G+R IR++ ++G + +L ++ K G + G + + +
Sbjct: 199 TKSDDTVVAIPYGSRHIRLV-LKGPDHLYLETKTLQGTK----GENSLSSTGTFLVDNSS 253
Query: 772 FQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYG 831
+ + D E L GP + + ++ N G + T+Q + + W+
Sbjct: 254 VDFQKFPDKEILRMAGP----LTADFIVKIRNSG-SADSTVQFIFYQPIIHR----WRET 304
Query: 832 HWTECSVTCGTGIRRQTAHCIK-KGRGMVKATFCD--PET-QPNGRQKKCHEKACP---- 883
+ CS TCG G + +A C + +V +C PE +P + ++C+ CP
Sbjct: 305 DFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDG 364
Query: 884 -------------PRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE-QALPPTDCQHL 929
PRW A W ACS++CG G + R V C++ + ++ C +
Sbjct: 365 YKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYT 423
Query: 930 LKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKN---HDEPCDVTRKPN 986
K CN CP W WS C+V+CG G+R R V C + H C KP+
Sbjct: 424 PKMPIAQPCN-IFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPH 481
Query: 987 SRALC 991
+ C
Sbjct: 482 IKEEC 486
Score = 94.0 bits (232), Expect = 1e-18
Identities = 57/210 (27%), Positives = 83/210 (39%), Gaps = 38/210 (18%)
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGI--PPPLSMSCNPEPCE 1425
W+ ++ CS C GG+++ +C D R +R + +C + P P CN +PC
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1426 A------------------WQVEPWSQCSRSCGGGVQERGVFC------------PGGLC 1455
A W+ PW+ CS SCGGG+Q R V C C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 1456 DWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCD 1515
+T + CN C W W C+ +CG G + R V C+ G T C
Sbjct: 421 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG-----CS 475
Query: 1516 HKPRPPEFKKC-NQQACKKSADLLCTKDKL 1544
K +P ++C C K + L + KL
Sbjct: 476 PKTKPHIKEECIVPTPCYKPKEKLPVEAKL 505
Score = 70.1 bits (170), Expect = 2e-11
Identities = 46/169 (27%), Positives = 69/169 (40%), Gaps = 38/169 (22%)
Query: 1318 IVGNWSE-----CSTTCGLGAYWRRVECSTQMDSDCAAIQ---------RPDP-AKRCHL 1362
I+ W E CS TCG G EC + A Q +P P + C+L
Sbjct: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
Query: 1363 RPCAG------------------WKVGNWSKCSRNCSGGFKIREIQCV--DSRDH-RNLR 1401
PC W+ W+ CS +C GG + R + CV D + H ++
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 1402 PFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFC 1450
+ C + + P++ CN C W + WS C+ +CG G++ R V C
Sbjct: 417 EWKCMYTPKM--PIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 53.1 bits (126), Expect = 2e-06
Identities = 32/123 (26%), Positives = 48/123 (39%), Gaps = 15/123 (12%)
Query: 1312 HGSAHWIVGNWSECSTTCGLGAYWRRVEC---------STQMDSDCAAIQRPDPAKRCHL 1362
H W W+ CS++CG G R V C ++ + C + A+ C++
Sbjct: 375 HPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNI 434
Query: 1363 RPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC-NP 1421
C W WS C+ C G + R + C+ DHR + C P + C P
Sbjct: 435 FDCPKWLAQEWSPCTVTCGQGLRYRVVLCI---DHRGMHTGGCS--PKTKPHIKEECIVP 489
Query: 1422 EPC 1424
PC
Sbjct: 490 TPC 492
Score = 34.7 bits (78), Expect = 0.76
Identities = 18/62 (29%), Positives = 26/62 (41%)
Query: 1476 ATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
A G W CS +CGGG +C+ S+ + + C + PPE Q C
Sbjct: 38 AWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHN 97
Query: 1536 DL 1537
D+
Sbjct: 98 DV 99
Score = 32.7 bits (73), Expect = 2.9
Identities = 18/54 (33%), Positives = 26/54 (48%), Gaps = 11/54 (20%)
Query: 1371 GNWSKCSRNCSGGFKIREIQCVDSR--DHRNLRPFHCQFLAGIPPPLSMSCNPE 1422
G WS+CSR C GG +C+ S+ + RN+R C ++ C PE
Sbjct: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCS---------NVDCPPE 84
Score = 32.3 bits (72), Expect = 3.8
Identities = 12/18 (66%), Positives = 15/18 (83%), Gaps = 2/18 (11%)
Query: 1425 EAWQVEPWSQCSRSCGGG 1442
+AW PWS+CSR+CGGG
Sbjct: 37 DAWG--PWSECSRTCGGG 52
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 201 bits (510), Expect = 6e-51
Identities = 155/528 (29%), Positives = 243/528 (46%), Gaps = 60/528 (11%)
Query: 57 PVRVDASGHFLSY---------GLHYPITSSRRKRDLDGSED-----WVYYRISHEEKDL 102
PVR DA G +S+ G+ + R G + ++Y ++ +DL
Sbjct: 61 PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
Query: 103 FFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTA-----AL 157
L N ++ ME + G ++ L G+ L G G A AL
Sbjct: 121 HLRLRPNARLVAPGATMEWQ-GEKGTTRVEP-------LLGSCLYVGDVAGLAEASSVAL 172
Query: 158 SACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHP--HIVYRRQKVPETKEPTCG---LKD 212
S C GL G ++ +FFIEP++K + H+VYRR P T P G L
Sbjct: 173 SNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR---PPTSPPLGGPQALDT 229
Query: 213 SVNISQKQELWREKW--ERHNLPSRSLSRRSISKERW-VETLVVADTKMIEYHGSENVES 269
++ L R E H SR +RR + + + +E L+ D ++++HG E+V+
Sbjct: 230 GASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQK 289
Query: 270 YILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEE-EEQGLKIVHHAEKTLSSFCKWQKSI 328
Y+LT+MN+V ++H+ S+G I++V+VR+ILL + L + + ++L + C+W
Sbjct: 290 YLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQ 349
Query: 329 NPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAF 388
+ +HD A+ LTR+D P G + ++GMC P RSC +N + G AF
Sbjct: 350 QKPDTGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAF 404
Query: 389 TIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGW 448
+AHE GH G++HDG+ N C R IM+ +Q WS+CS++ ++R+L
Sbjct: 405 VVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS-- 462
Query: 449 GFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVE--NVCQTLWCSVKG- 505
CL D P + PG+ Y ++ QC+ +G C + C+ LWCS
Sbjct: 463 YDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDN 522
Query: 506 --FCRSKLDAAADGTQCGEKKW---CMAGKCITVGKKPESIPGGWGRW 548
FC++K DGT C K+ +A C S GG GRW
Sbjct: 523 PYFCKTKKGPPLDGTMCAPGKFRPGAVAHACY------PSTLGGQGRW 564
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 197 bits (500), Expect = 9e-50
Identities = 142/484 (29%), Positives = 213/484 (44%), Gaps = 55/484 (11%)
Query: 555 SRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTV 614
S G G A + + P + C G ++Y+LCN + C + + R++QC+ ++
Sbjct: 266 SNNHGVGTHGATQSFSQPA-RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
Query: 615 PYKNELYHWFPIFNPA--HPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGI 672
P+ Y W P CEL C+ + +F + + VIDGTPC + G + +C++G
Sbjct: 325 PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTA--ICVSGQ 382
Query: 673 CKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS-GYVDIGLIPKGARDIRV 731
CK +GCD + S+ D+CGVC GD + CQ V +FK S GY + IP+GA I +
Sbjct: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
Query: 732 MEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDL-----EKLMAT 786
E+ + N+LA+RS + +NG + I G Y+ GT+F Y R ++ E +A
Sbjct: 443 TEMYKSNNYLALRSRS-GRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
Query: 787 GPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGH-WTECSVTCGTGIR 845
GPTNE + + ++ Q NPG+ YEY I G + Q + G + VT G
Sbjct: 502 GPTNEILDVYMIHQQPNPGVHYEYVIM--GTNAISPQVPPHRRPGEPFNGQMVTEG---- 555
Query: 846 RQTAHCIKKG--------RGMVKATFCDPETQ-----------PNGRQKKCHEKACPPR- 885
R +KG RG F Q P+ PPR
Sbjct: 556 RSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRR 615
Query: 886 -----WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNR 940
W CS TCG G + C+ +E P + C +KP
Sbjct: 616 SRDHNWKQLGTTECSTTCG-KGSQYPIFRCVHRSTHEE--APESYCDSSMKPTPEEEPCN 672
Query: 941 DILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE--------PCDVTRKPNSRALCG 992
CP+ W +G WSECS +CG G++ R V C + + C KP + + C
Sbjct: 673 IFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQ 732
Query: 993 LQQC 996
L+ C
Sbjct: 733 LKIC 736
Score = 134 bits (337), Expect = 7e-31
Identities = 83/273 (30%), Positives = 121/273 (44%), Gaps = 34/273 (12%)
Query: 1321 NWSECSTTCGLGAYWRRVECSTQM-----DSDCAAIQRPDPAKRCHLRPCA-GWKVGNWS 1374
+W+ CS CG+G R V+C + + D +C RP+ + C + PCA W + WS
Sbjct: 744 DWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWS 803
Query: 1375 -KCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA---WQVE 1430
+CS C G + R + C+ + H + P + P + C+ PC W
Sbjct: 804 ERCSAECGAGVRTRSVVCMTN--HVSSLPL--EGCGNNRPAEATPCDNGPCTGKVEWFAG 859
Query: 1431 PWSQCSRSCGGGVQERGVFC-----------PGGLCDWTKRPTSTMSCNEHLC-CHWATG 1478
WSQCS CG G Q+R V C C + ++P S SC+ C W +
Sbjct: 860 SWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFST 919
Query: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLL 1538
W +CS SC GGF+ R V+C+ + + LCD + +P E + CN Q C D
Sbjct: 920 EWSMCSKSCQGGFRVREVRCLSDDMTLSN-----LCDPQLKPEERESCNPQDCVPEVDEN 974
Query: 1539 CTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
C KDK C + + C + CC SC
Sbjct: 975 C-KDKYYN--CNVVVQARLCVYNYYKTACCASC 1004
Score = 127 bits (320), Expect = 7e-29
Identities = 80/266 (30%), Positives = 116/266 (43%), Gaps = 44/266 (16%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVECS--------TQMDSDCAAIQRPDPAKRCHLRPCA 1366
A W +G WSECS TCGLG R+V C T C +++P+ C L+ C+
Sbjct: 678 AFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
Query: 1367 GWKVG-NWSKCSRNCSGGFKIREIQCV--------DSRDHRNLRPFHCQFLAGIPPPLSM 1417
W++ +W+ CS C G + R+++CV D + LRP +
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIE----------- 786
Query: 1418 SCNPEPC-EAWQVEPWSQ-CSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSC 1467
+C+ PC ++W + WS+ CS CG GV+ R V C P C RP C
Sbjct: 787 NCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPC 845
Query: 1468 NEHLCC---HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFK 1524
+ C W G+W CS CG G Q+R V CV + E D C +PP +
Sbjct: 846 DNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQ 905
Query: 1525 KCNQQACKKSADLLCTKDKLSASFCQ 1550
C+ + C A T+ + + CQ
Sbjct: 906 SCHLKPC--GAKWFSTEWSMCSKSCQ 929
Score = 115 bits (289), Expect = 3e-25
Identities = 63/179 (35%), Positives = 86/179 (48%), Gaps = 10/179 (5%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKG-RGMVKATFCDPETQPNGRQKKCHEKACPPRW 886
W+ TECS TCG G + C+ + ++CD +P ++ C+ CP W
Sbjct: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFW 680
Query: 887 WAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPS 946
GEW CS TCG G + R VLC Q + + P CQHL KP+T +C I S
Sbjct: 681 DIGEWSECSKTCG-LGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC--S 737
Query: 947 DWTV-GNWSECSVSCGGGVRIRSVTCAKN-----HDEPCDVTRKPNSRALCGLQQCPSS 999
+W + +W+ CSV CG G R R V C N DE C++ +PN C + C S
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKS 796
Score = 107 bits (268), Expect = 7e-23
Identities = 70/237 (29%), Positives = 108/237 (45%), Gaps = 32/237 (13%)
Query: 1321 NW-----SECSTTCGLGAYWRRVEC------STQMDSDCAAIQRPDPAKR-CHLRPC-AG 1367
NW +ECSTTCG G+ + C +S C + +P P + C++ PC A
Sbjct: 620 NWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAF 679
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNL--RPFHCQFLAGIPPPLSMSCNPEPCE 1425
W +G WS+CS+ C G + R++ C +R+L +P+ CQ L P + +C + C
Sbjct: 680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS 737
Query: 1426 AWQVE-PWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSCNEHLCC-HW 1475
WQ+ W+ CS CG G + R V C + C+ RP +C+ C W
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSW 797
Query: 1476 ATGNW-DLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
W + CS CG G + R+V C+ + + + C + RP E C+ C
Sbjct: 798 FLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG---CGNN-RPAEATPCDNGPC 850
Score = 97.4 bits (241), Expect = 1e-19
Identities = 56/175 (32%), Positives = 78/175 (44%), Gaps = 10/175 (5%)
Query: 828 WQYGHWTE-CSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPR- 885
W W+E CS CG G+R ++ C+ + C +P C C +
Sbjct: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRP-AEATPCDNGPCTGKV 854
Query: 886 -WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILC 944
W+AG W CS CG G ++R V+C++ + L P++C L KP + SC+ C
Sbjct: 855 EWFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKP-C 912
Query: 945 PSDWTVGNWSECSVSCGGGVRIRSVTCAKNH---DEPCDVTRKPNSRALCGLQQC 996
+ W WS CS SC GG R+R V C + CD KP R C Q C
Sbjct: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
Score = 93.6 bits (231), Expect = 1e-18
Identities = 57/173 (32%), Positives = 79/173 (45%), Gaps = 14/173 (8%)
Query: 833 WTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEW- 891
WT CSV CG G R + C+ +V C+ + +PN + C C W+ EW
Sbjct: 745 WTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIEN-CDMGPCAKSWFLTEWS 803
Query: 892 EACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVG 951
E CSA CG G + R+V+C+ VS +LP C + + N +W G
Sbjct: 804 ERCSAECGA-GVRTRSVVCMTNHVS---SLPLEGCGNNRPAEATPCDNGPCTGKVEWFAG 859
Query: 952 NWSECSVSCGGGVRIRSVTCA-KNHD-------EPCDVTRKPNSRALCGLQQC 996
+WS+CS+ CG G + R V C KN D C KP S+ C L+ C
Sbjct: 860 SWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
Score = 88.6 bits (218), Expect = 4e-17
Identities = 50/155 (32%), Positives = 70/155 (45%), Gaps = 14/155 (9%)
Query: 827 FWQYGHWTECSVTCGTGIRRQTAHC--IKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
FW G W+ECS TCG G++ + C + R + + + C K C
Sbjct: 679 FWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSE 738
Query: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQT---MVSDEQALPPTDCQHLLKPKTLLSCNRD 941
+W +CS CG G++ R V C+ +V DE +C L+P + +C+
Sbjct: 739 WQIRTDWTSCSVPCGV-GQRTRDVKCVSNIGDVVDDE------ECNMKLRPNDIENCDMG 791
Query: 942 ILCPSDWTVGNWSE-CSVSCGGGVRIRSVTCAKNH 975
C W + WSE CS CG GVR RSV C NH
Sbjct: 792 -PCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNH 825
Score = 87.4 bits (215), Expect = 1e-16
Identities = 44/122 (36%), Positives = 63/122 (51%), Gaps = 16/122 (13%)
Query: 1313 GSAHWIVGNWSECSTTCGLGAYWRRVECSTQM--------DSDCAAIQRPDPAKRCHLRP 1364
G W G+WS+CS CG G R V C + S+C+ +++P + CHL+P
Sbjct: 852 GKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKP 911
Query: 1365 C-AGWKVGNWSKCSRNCSGGFKIREIQCV-DSRDHRNLRPFHCQFLAGIPPPLSMSCNPE 1422
C A W WS CS++C GGF++RE++C+ D NL C + P SCNP+
Sbjct: 912 CGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNL----CD--PQLKPEERESCNPQ 965
Query: 1423 PC 1424
C
Sbjct: 966 DC 967
Score = 44.7 bits (104), Expect = 7e-04
Identities = 16/28 (57%), Positives = 17/28 (60%)
Query: 542 PGGWGRWSPWSHCSRTCGAGVQSAERLC 569
PG WG W PWS CSR+C GV R C
Sbjct: 53 PGVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 33.1 bits (74), Expect = 2.2
Identities = 12/16 (75%), Positives = 13/16 (81%)
Query: 1431 PWSQCSRSCGGGVQER 1446
PWS CSRSC GGV E+
Sbjct: 61 PWSACSRSCSGGVMEQ 76
Score = 33.1 bits (74), Expect = 2.2
Identities = 18/55 (32%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
Query: 1483 CSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADL 1537
CST+CG G Q +CV ++ + C KP P E + CN C D+
Sbjct: 629 CSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEE-EPCNIFPCPAFWDI 682
Score = 32.3 bits (72), Expect = 3.8
Identities = 12/25 (48%), Positives = 15/25 (60%)
Query: 1476 ATGNWDLCSTSCGGGFQKRTVQCVP 1500
A G W CS SC GG ++T C+P
Sbjct: 58 AWGPWSACSRSCSGGVMEQTRPCLP 82
Score = 32.0 bits (71), Expect = 4.9
Identities = 11/19 (57%), Positives = 14/19 (73%)
Query: 551 WSHCSRTCGAGVQSAERLC 569
WS CS+TCG G+Q + LC
Sbjct: 685 WSECSKTCGLGMQHRQVLC 703
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 189 bits (480), Expect = 2e-47
Identities = 107/323 (33%), Positives = 173/323 (53%), Gaps = 23/323 (7%)
Query: 545 WGRWSPWSHCSRTCGAGVQSAERLC----NNPEPKFGGKYCTGERKRYRLCNVHPCRSEA 600
WG W+ W+ CSR+CG GV S ER C P G + CTG KRY+LC V C +
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 601 PTFRQMQCSEFDTVPYKNELYHWFPIFNPAH------PCELYCRPIDGQFSEKMLDAVID 654
+FR+ QC F++ Y + W P++ + PC+L+C +DGQ +++ D
Sbjct: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQ--RQLMVPARD 167
Query: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS 714
GT C + + R VC++G C+ +GCD + S T D+CG+C GDGSSC V +++
Sbjct: 168 GTSC-KLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
Query: 715 -GYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQ 773
GY + IP GARDI+++E + + + LA+ +++ Y+ NG + + N+ +AGTV +
Sbjct: 227 LGYSLVTHIPAGARDIQIVERKKSADVLAL-ADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
Query: 774 YDRKGD-----LEKLMATGPTNESVWIQLLFQ-VTNPGIKYEYTIQKDGLDNDVEQQMYF 827
Y R D +E ++A GPTN+ + + + Q +P I +EYT+ + ++ Q +
Sbjct: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP--PHESRPQPIY 343
Query: 828 WQYGHWTECSVTCGTGIRRQTAH 850
+ + E G G+ H
Sbjct: 344 YGFSESAESQGLDGAGLMGFVPH 366
Score = 119 bits (298), Expect = 2e-26
Identities = 75/240 (31%), Positives = 104/240 (43%), Gaps = 32/240 (13%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVEC----STQMDSD-----CAAIQ--RPDPAKRCHLRPC 1365
W +WSECS TCG G +R V C S DS C A + RP+ K C C
Sbjct: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
Query: 1366 AG-WKVGNWSKCSRNCSGGFKI-REIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
W++ WS+C+ C + R+I+C S D + P P +C P
Sbjct: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC--SEDEKLCDP-------NTRPVGEKNCTGPP 736
Query: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLC-C 1473
C+ W V W CS SCG G R V+C P C +P + C + C
Sbjct: 737 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
Query: 1474 HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533
HW +W+ C+T+CG G +KR V C+ K + + C +PPE C ++ C K
Sbjct: 797 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK 856
Score = 110 bits (274), Expect = 1e-23
Identities = 78/274 (28%), Positives = 109/274 (39%), Gaps = 27/274 (9%)
Query: 1317 WIVGNWSECSTTCG-LGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPC-AGWKVGNWS 1374
W + WSEC+ CG R + CS + C RP K C PC W V +W
Sbjct: 689 WEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWG 747
Query: 1375 KCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMS-CNPEPCEA-WQVEPW 1432
CS +C G IR + C S D R + CQ PL++ C + C A W + W
Sbjct: 748 PCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMET---KPLAIHPCGDKNCPAHWLAQDW 803
Query: 1433 SQCSRSCGGGVQERGVFC-----------PGGLCDWTKRPTSTMSCNEHLCCHWATGNWD 1481
+C+ +CG GV++R V C G C K+P +C E C W T W
Sbjct: 804 ERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWS 863
Query: 1482 LCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTK 1541
C+ +CG G + R V+C CD +P + C+ Q C +
Sbjct: 864 ECTKTCGVGVRMRDVKCYQGTDIVRG------CDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
Query: 1542 DKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTH 1575
D+ + +K + C CC SC H
Sbjct: 918 DQPGTNCALAIK-VNLCGHWYYSKACCRSCRPPH 950
Score = 107 bits (268), Expect = 7e-23
Identities = 62/174 (35%), Positives = 80/174 (45%), Gaps = 8/174 (4%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W W CS +CG G + +C +V + C ET+P C +K CP W
Sbjct: 741 WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP-CGDKNCPAHWL 799
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC-NRDILCPS 946
A +WE C+ TCG G KKR VLC++ Q +C KP +C R
Sbjct: 800 AQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF--- 855
Query: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNHD--EPCDVTRKPNSRALCGLQQCPS 998
W WSEC+ +CG GVR+R V C + D CD KP R C LQ CP+
Sbjct: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 909
Score = 91.7 bits (226), Expect = 5e-18
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 14/230 (6%)
Query: 825 MYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
MY W+ CS TC TG+ A C++ V ++CD T+P + C + C P
Sbjct: 565 MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
Query: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD-CQ--HLLKPKTLLSCNRD 941
RW W CS TCG G + R V C + + + +D C+ ++P+ +C R+
Sbjct: 625 RWETSSWSECSRTCG-EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC-RN 682
Query: 942 ILCPSDWTVGNWSECSVSCG-GGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSR 1000
C W + WSEC+ CG V R + C+++ ++ CD +P C C
Sbjct: 683 PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQW 741
Query: 1001 RVLK--PNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAI 1048
V P G+ G+ T++ V TS R++ P M T AI
Sbjct: 742 TVSDWGPCSGSCGQGR---TIRHVYCKTSDGRVV--PESQCQMETKPLAI 786
Score = 90.5 bits (223), Expect = 1e-17
Identities = 51/178 (28%), Positives = 74/178 (41%), Gaps = 11/178 (6%)
Query: 1306 KQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ-----MDSDCAAIQRPDPAKRC 1360
K T W V +W CS +CG G R V C T +S C +P C
Sbjct: 730 KNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC 789
Query: 1361 HLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC 1419
+ C A W +W +C+ C G K R + C++ + + + PP +C
Sbjct: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
Query: 1420 NPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL-----CDWTKRPTSTMSCNEHLC 1472
PC W PWS+C+++CG GV+ R V C G CD +P +C+ C
Sbjct: 850 FERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 907
Score = 75.5 bits (184), Expect = 4e-13
Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 22/137 (16%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDCAAIQRPDPAKRCHLRPCA 1366
AHW+ +W C+TTCG G R V C T+ +C ++P C RPC
Sbjct: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF 855
Query: 1367 GWKVGNWSKCSRNCSGGFKIREIQCVDSRD-HRNLRPFHCQFLAGIPPPLSMSCNPEPC- 1424
W WS+C++ C G ++R+++C D R P + P +C+ +PC
Sbjct: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPL-------VKPVGRQACDLQPCP 908
Query: 1425 -----EAWQVEPWSQCS 1436
++ Q +P + C+
Sbjct: 909 TEPPDDSCQDQPGTNCA 925
Score = 72.0 bits (175), Expect = 4e-12
Identities = 52/183 (28%), Positives = 71/183 (38%), Gaps = 28/183 (15%)
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA- 1426
WK+ + CS C+ G CV D + +C L P P+ C C+
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTR-PEPVHEFCAGRECQPR 625
Query: 1427 WQVEPWSQCSRSCGGGVQERGVFC-----PG-------GLCDWTK--RPTSTMSCNEHLC 1472
W+ WS+CSR+CG G Q R V C PG LC+ + RP +C C
Sbjct: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
Query: 1473 -CHWATGNWDLCSTSCG-GGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQA 1530
W W C+ CG R ++C +D+ LCD RP K C
Sbjct: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC---------SEDEKLCDPNTRPVGEKNCTGPP 736
Query: 1531 CKK 1533
C +
Sbjct: 737 CDR 739
Score = 53.9 bits (128), Expect = 1e-06
Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 13/133 (9%)
Query: 1412 PPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQER--------GVFCPGGLCDWTKRPTS 1463
P +P W++ CS +C GV GV CD RP
Sbjct: 553 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 612
Query: 1464 TMS-CNEHLC-CHWATGNWDLCSTSCGGGFQKRTVQC--VPSEG-NKTEDQDQCLCDHKP 1518
C C W T +W CS +CG G+Q R V+C + S G + + D C
Sbjct: 613 VHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAV 672
Query: 1519 RPPEFKKCNQQAC 1531
RP E K C AC
Sbjct: 673 RPEERKTCRNPAC 685
Score = 47.0 bits (110), Expect = 1e-04
Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 822 EQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKA 881
E+ + W W+EC+ TCG G+R + C +G +V+ CDP +P GRQ C +
Sbjct: 851 ERPCFKWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRG--CDPLVKPVGRQ-ACDLQP 906
Query: 882 CP 883
CP
Sbjct: 907 CP 908
Score = 44.3 bits (103), Expect = 0.001
Identities = 22/81 (27%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 815 DGLDNDVEQQMYFW-QYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGR 873
+ L+ + ++W ++ WT CS +CG G+ Q HC+++ R V T + R
Sbjct: 37 NSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR 96
Query: 874 QKKCHEKACPPRWWAGEWEAC 894
+ C + CPP + E C
Sbjct: 97 YQLCRVQECPPDGRSFREEQC 117
Score = 37.0 bits (84), Expect = 0.15
Identities = 17/53 (32%), Positives = 26/53 (49%)
Query: 549 SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAP 601
SPWS C++TCG GV+ + C G + + C++ PC +E P
Sbjct: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP 912
Score = 34.7 bits (78), Expect = 0.76
Identities = 21/63 (33%), Positives = 28/63 (44%), Gaps = 12/63 (19%)
Query: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNH--------DEPCDVTRKPNSRALCGLQQCPS 998
+WT W+ CS SCGGGV + C + + C T K LC +Q+CP
Sbjct: 52 EWT--KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPP 107
Query: 999 SRR 1001
R
Sbjct: 108 DGR 110
Score = 34.3 bits (77), Expect = 0.99
Identities = 19/62 (30%), Positives = 27/62 (43%), Gaps = 10/62 (16%)
Query: 1480 WDLCSTSCGGGFQKRTVQC-------VPSEGNKT---EDQDQCLCDHKPRPPEFKKCNQQ 1529
W CS SCGGG + C VP GN+T + LC + PP+ + ++
Sbjct: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
Query: 1530 AC 1531
C
Sbjct: 116 QC 117
Score = 32.3 bits (72), Expect = 3.8
Identities = 35/140 (25%), Positives = 49/140 (35%), Gaps = 28/140 (20%)
Query: 509 SKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCG--------A 560
S L AA+ + E+K C C G S WS C+ CG
Sbjct: 663 SDLCEAAEAVRPEERKTCRNPAC-----------GPQWEMSEWSECTAKCGERSVVTRDI 711
Query: 561 GVQSAERLCNNPEPKFGGKYCTGE--RKRYRLCNVHPCR---SEAPTFRQMQCSEFD--T 613
E+LC+ G K CTG +++ + + PC + T R + C D
Sbjct: 712 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 771
Query: 614 VPYKNELYHWFPIFNPAHPC 633
VP P+ HPC
Sbjct: 772 VPESQCQMETKPL--AIHPC 789
Score = 32.0 bits (71), Expect = 4.9
Identities = 25/101 (24%), Positives = 37/101 (36%), Gaps = 6/101 (5%)
Query: 542 PGGWGRWSPWSH--CSRTCGAGVQSAERLCNNPE-PKFGGKYC---TGERKRYRLCNVHP 595
P RW SH CS TC GV SA +C + + YC T + C
Sbjct: 562 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 621
Query: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELY 636
C+ T +CS Y+ + + + +P +Y
Sbjct: 622 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 189 bits (480), Expect = 2e-47
Identities = 107/323 (33%), Positives = 173/323 (53%), Gaps = 23/323 (7%)
Query: 545 WGRWSPWSHCSRTCGAGVQSAERLC----NNPEPKFGGKYCTGERKRYRLCNVHPCRSEA 600
WG W+ W+ CSR+CG GV S ER C P G + CTG KRY+LC V C +
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 601 PTFRQMQCSEFDTVPYKNELYHWFPIFNPAH------PCELYCRPIDGQFSEKMLDAVID 654
+FR+ QC F++ Y + W P++ + PC+L+C +DGQ +++ D
Sbjct: 110 RSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQ--RQLMVPARD 167
Query: 655 GTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGS 714
GT C + + R VC++G C+ +GCD + S T D+CG+C GDGSSC V +++
Sbjct: 168 GTSC-KLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
Query: 715 -GYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQ 773
GY + IP GARDI+++E + + + LA+ +++ Y+ NG + + N+ +AGTV +
Sbjct: 227 LGYSLVTHIPAGARDIQIVERKKSADVLAL-ADEAGYYFFNGNYKVDSPKNFNIAGTVVK 285
Query: 774 YDRKGD-----LEKLMATGPTNESVWIQLLFQ-VTNPGIKYEYTIQKDGLDNDVEQQMYF 827
Y R D +E ++A GPTN+ + + + Q +P I +EYT+ + ++ Q +
Sbjct: 286 YRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP--PHESRPQPIY 343
Query: 828 WQYGHWTECSVTCGTGIRRQTAH 850
+ + E G G+ H
Sbjct: 344 YGFSESAESQGLDGAGLMGFVPH 366
Score = 119 bits (298), Expect = 2e-26
Identities = 75/240 (31%), Positives = 104/240 (43%), Gaps = 32/240 (13%)
Query: 1317 WIVGNWSECSTTCGLGAYWRRVEC----STQMDSD-----CAAIQ--RPDPAKRCHLRPC 1365
W +WSECS TCG G +R V C S DS C A + RP+ K C C
Sbjct: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
Query: 1366 AG-WKVGNWSKCSRNCSGGFKI-REIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
W++ WS+C+ C + R+I+C S D + P P +C P
Sbjct: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC--SEDEKLCDP-------NTRPVGEKNCTGPP 736
Query: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLC-C 1473
C+ W V W CS SCG G R V+C P C +P + C + C
Sbjct: 737 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 796
Query: 1474 HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533
HW +W+ C+T+CG G +KR V C+ K + + C +PPE C ++ C K
Sbjct: 797 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK 856
Score = 110 bits (274), Expect = 1e-23
Identities = 78/274 (28%), Positives = 109/274 (39%), Gaps = 27/274 (9%)
Query: 1317 WIVGNWSECSTTCG-LGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPC-AGWKVGNWS 1374
W + WSEC+ CG R + CS + C RP K C PC W V +W
Sbjct: 689 WEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWG 747
Query: 1375 KCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMS-CNPEPCEA-WQVEPW 1432
CS +C G IR + C S D R + CQ PL++ C + C A W + W
Sbjct: 748 PCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMET---KPLAIHPCGDKNCPAHWLAQDW 803
Query: 1433 SQCSRSCGGGVQERGVFC-----------PGGLCDWTKRPTSTMSCNEHLCCHWATGNWD 1481
+C+ +CG GV++R V C G C K+P +C E C W T W
Sbjct: 804 ERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWS 863
Query: 1482 LCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTK 1541
C+ +CG G + R V+C CD +P + C+ Q C +
Sbjct: 864 ECTKTCGVGVRMRDVKCYQGTDIVRG------CDPLVKPVGRQACDLQPCPTEPPDDSCQ 917
Query: 1542 DKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTH 1575
D+ + +K + C CC SC H
Sbjct: 918 DQPGTNCALAIK-VNLCGHWYYSKACCRSCRPPH 950
Score = 107 bits (268), Expect = 7e-23
Identities = 62/174 (35%), Positives = 80/174 (45%), Gaps = 8/174 (4%)
Query: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
W W CS +CG G + +C +V + C ET+P C +K CP W
Sbjct: 741 WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP-CGDKNCPAHWL 799
Query: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC-NRDILCPS 946
A +WE C+ TCG G KKR VLC++ Q +C KP +C R
Sbjct: 800 AQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF--- 855
Query: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNHD--EPCDVTRKPNSRALCGLQQCPS 998
W WSEC+ +CG GVR+R V C + D CD KP R C LQ CP+
Sbjct: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 909
Score = 91.7 bits (226), Expect = 5e-18
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 14/230 (6%)
Query: 825 MYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
MY W+ CS TC TG+ A C++ V ++CD T+P + C + C P
Sbjct: 565 MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 624
Query: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD-CQ--HLLKPKTLLSCNRD 941
RW W CS TCG G + R V C + + + +D C+ ++P+ +C R+
Sbjct: 625 RWETSSWSECSRTCG-EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC-RN 682
Query: 942 ILCPSDWTVGNWSECSVSCG-GGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSR 1000
C W + WSEC+ CG V R + C+++ ++ CD +P C C
Sbjct: 683 PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQW 741
Query: 1001 RVLK--PNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAI 1048
V P G+ G+ T++ V TS R++ P M T AI
Sbjct: 742 TVSDWGPCSGSCGQGR---TIRHVYCKTSDGRVV--PESQCQMETKPLAI 786
Score = 90.5 bits (223), Expect = 1e-17
Identities = 51/178 (28%), Positives = 74/178 (41%), Gaps = 11/178 (6%)
Query: 1306 KQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ-----MDSDCAAIQRPDPAKRC 1360
K T W V +W CS +CG G R V C T +S C +P C
Sbjct: 730 KNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC 789
Query: 1361 HLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC 1419
+ C A W +W +C+ C G K R + C++ + + + PP +C
Sbjct: 790 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 849
Query: 1420 NPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL-----CDWTKRPTSTMSCNEHLC 1472
PC W PWS+C+++CG GV+ R V C G CD +P +C+ C
Sbjct: 850 FERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 907
Score = 75.5 bits (184), Expect = 4e-13
Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 22/137 (16%)
Query: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDCAAIQRPDPAKRCHLRPCA 1366
AHW+ +W C+TTCG G R V C T+ +C ++P C RPC
Sbjct: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF 855
Query: 1367 GWKVGNWSKCSRNCSGGFKIREIQCVDSRD-HRNLRPFHCQFLAGIPPPLSMSCNPEPC- 1424
W WS+C++ C G ++R+++C D R P + P +C+ +PC
Sbjct: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPL-------VKPVGRQACDLQPCP 908
Query: 1425 -----EAWQVEPWSQCS 1436
++ Q +P + C+
Sbjct: 909 TEPPDDSCQDQPGTNCA 925
Score = 72.0 bits (175), Expect = 4e-12
Identities = 52/183 (28%), Positives = 71/183 (38%), Gaps = 28/183 (15%)
Query: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA- 1426
WK+ + CS C+ G CV D + +C L P P+ C C+
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTR-PEPVHEFCAGRECQPR 625
Query: 1427 WQVEPWSQCSRSCGGGVQERGVFC-----PG-------GLCDWTK--RPTSTMSCNEHLC 1472
W+ WS+CSR+CG G Q R V C PG LC+ + RP +C C
Sbjct: 626 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 685
Query: 1473 -CHWATGNWDLCSTSCG-GGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQA 1530
W W C+ CG R ++C +D+ LCD RP K C
Sbjct: 686 GPQWEMSEWSECTAKCGERSVVTRDIRC---------SEDEKLCDPNTRPVGEKNCTGPP 736
Query: 1531 CKK 1533
C +
Sbjct: 737 CDR 739
Score = 53.9 bits (128), Expect = 1e-06
Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 13/133 (9%)
Query: 1412 PPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQER--------GVFCPGGLCDWTKRPTS 1463
P +P W++ CS +C GV GV CD RP
Sbjct: 553 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 612
Query: 1464 TMS-CNEHLC-CHWATGNWDLCSTSCGGGFQKRTVQC--VPSEG-NKTEDQDQCLCDHKP 1518
C C W T +W CS +CG G+Q R V+C + S G + + D C
Sbjct: 613 VHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAV 672
Query: 1519 RPPEFKKCNQQAC 1531
RP E K C AC
Sbjct: 673 RPEERKTCRNPAC 685
Score = 47.0 bits (110), Expect = 1e-04
Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 822 EQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKA 881
E+ + W W+EC+ TCG G+R + C +G +V+ CDP +P GRQ C +
Sbjct: 851 ERPCFKWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRG--CDPLVKPVGRQ-ACDLQP 906
Query: 882 CP 883
CP
Sbjct: 907 CP 908
Score = 44.3 bits (103), Expect = 0.001
Identities = 22/81 (27%), Positives = 38/81 (46%), Gaps = 1/81 (1%)
Query: 815 DGLDNDVEQQMYFW-QYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGR 873
+ L+ + ++W ++ WT CS +CG G+ Q HC+++ R V T + R
Sbjct: 37 NSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKR 96
Query: 874 QKKCHEKACPPRWWAGEWEAC 894
+ C + CPP + E C
Sbjct: 97 YQLCRVQECPPDGRSFREEQC 117
Score = 37.0 bits (84), Expect = 0.15
Identities = 17/53 (32%), Positives = 26/53 (49%)
Query: 549 SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAP 601
SPWS C++TCG GV+ + C G + + C++ PC +E P
Sbjct: 860 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP 912
Score = 34.7 bits (78), Expect = 0.76
Identities = 21/63 (33%), Positives = 28/63 (44%), Gaps = 12/63 (19%)
Query: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNH--------DEPCDVTRKPNSRALCGLQQCPS 998
+WT W+ CS SCGGGV + C + + C T K LC +Q+CP
Sbjct: 52 EWT--KWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSK--RYQLCRVQECPP 107
Query: 999 SRR 1001
R
Sbjct: 108 DGR 110
Score = 34.3 bits (77), Expect = 0.99
Identities = 19/62 (30%), Positives = 27/62 (43%), Gaps = 10/62 (16%)
Query: 1480 WDLCSTSCGGGFQKRTVQC-------VPSEGNKT---EDQDQCLCDHKPRPPEFKKCNQQ 1529
W CS SCGGG + C VP GN+T + LC + PP+ + ++
Sbjct: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
Query: 1530 AC 1531
C
Sbjct: 116 QC 117
Score = 32.3 bits (72), Expect = 3.8
Identities = 35/140 (25%), Positives = 49/140 (35%), Gaps = 28/140 (20%)
Query: 509 SKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCG--------A 560
S L AA+ + E+K C C G S WS C+ CG
Sbjct: 663 SDLCEAAEAVRPEERKTCRNPAC-----------GPQWEMSEWSECTAKCGERSVVTRDI 711
Query: 561 GVQSAERLCNNPEPKFGGKYCTGE--RKRYRLCNVHPCR---SEAPTFRQMQCSEFD--T 613
E+LC+ G K CTG +++ + + PC + T R + C D
Sbjct: 712 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 771
Query: 614 VPYKNELYHWFPIFNPAHPC 633
VP P+ HPC
Sbjct: 772 VPESQCQMETKPL--AIHPC 789
Score = 32.0 bits (71), Expect = 4.9
Identities = 25/101 (24%), Positives = 37/101 (36%), Gaps = 6/101 (5%)
Query: 542 PGGWGRWSPWSH--CSRTCGAGVQSAERLCNNPE-PKFGGKYC---TGERKRYRLCNVHP 595
P RW SH CS TC GV SA +C + + YC T + C
Sbjct: 562 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 621
Query: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELY 636
C+ T +CS Y+ + + + +P +Y
Sbjct: 622 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,496,672
Number of Sequences: 37866
Number of extensions: 4141876
Number of successful extensions: 18959
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 390
Number of HSP's that attempted gapping in prelim test: 13375
Number of HSP's gapped (non-prelim): 3044
length of query: 1594
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1478
effective length of database: 13,855,062
effective search space: 20477781636
effective search space used: 20477781636
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.