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Search of human proteins with 50348666
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
(468 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50348666 peroxisome proliferative activated receptor, alpha [... 947 0.0
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 947 0.0
gi|5453940 peroxisome proliferative activated receptor, delta is... 560 e-160
gi|116284373 peroxisome proliferative activated receptor gamma i... 510 e-144
gi|20336229 peroxisome proliferative activated receptor gamma is... 510 e-144
gi|116284368 peroxisome proliferative activated receptor gamma i... 510 e-144
gi|116284370 peroxisome proliferative activated receptor gamma i... 510 e-144
gi|29171750 peroxisome proliferative activated receptor, delta i... 442 e-124
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 183 3e-46
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 180 2e-45
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 180 2e-45
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 180 2e-45
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 179 6e-45
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 178 8e-45
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 156 3e-38
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 156 3e-38
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 154 2e-37
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 151 1e-36
gi|11415052 retinoid X receptor, beta [Homo sapiens] 143 3e-34
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 137 2e-32
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom... 137 3e-32
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 137 3e-32
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 136 4e-32
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 136 4e-32
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso... 129 6e-30
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 129 6e-30
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso... 129 6e-30
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 125 1e-28
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 120 3e-27
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 119 8e-27
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 947 bits (2448), Expect = 0.0
Identities = 468/468 (100%), Positives = 468/468 (100%)
Query: 1 MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC 60
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
Sbjct: 1 MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC 60
Query: 61 PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
Sbjct: 61 PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120
Query: 121 GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE 180
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
Sbjct: 121 GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE 180
Query: 181 KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV 240
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
Sbjct: 181 KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV 240
Query: 241 IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL 300
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
Sbjct: 241 IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL 300
Query: 301 DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD 360
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
Sbjct: 301 DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD 360
Query: 361 FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI 420
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
Sbjct: 361 FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI 420
Query: 421 FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Sbjct: 421 FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 947 bits (2448), Expect = 0.0
Identities = 468/468 (100%), Positives = 468/468 (100%)
Query: 1 MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC 60
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
Sbjct: 1 MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC 60
Query: 61 PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
Sbjct: 61 PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120
Query: 121 GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE 180
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
Sbjct: 121 GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE 180
Query: 181 KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV 240
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
Sbjct: 181 KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV 240
Query: 241 IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL 300
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
Sbjct: 241 IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL 300
Query: 301 DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD 360
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
Sbjct: 301 DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD 360
Query: 361 FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI 420
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
Sbjct: 361 FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI 420
Query: 421 FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Sbjct: 421 FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
>gi|5453940 peroxisome proliferative activated receptor, delta
isoform 1 [Homo sapiens]
Length = 441
Score = 560 bits (1444), Expect = e-160
Identities = 275/398 (69%), Positives = 332/398 (83%), Gaps = 2/398 (0%)
Query: 72 LSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIR 131
LS +SSP S+ + G D + G+LN+ECR+CGDKASG+HYGVHACEGCKGFFRRTIR
Sbjct: 45 LSRSSSPPSLLDQLQMGC-DGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIR 103
Query: 132 LKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTC 191
+KL Y+KC+RSCKIQKKNRNKCQYCRF KCL++GMSHNAIRFGRMP +EK KL A +
Sbjct: 104 MKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTAN 163
Query: 192 EHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE 251
E + + ADLK+ +K IY AYLKNFNM K KAR IL+GKAS+ PFVIHD+ETL AE
Sbjct: 164 EGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE 223
Query: 252 KTLVAKLVANGIQN-KEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK 310
K LV K + NG+ KE V +F+ CQCT+VETV ELTEFAK+IP F++L LNDQVTLLK
Sbjct: 224 KGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK 283
Query: 311 YGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL 370
YGV+EAIFAML+S++NKDG+LVA G+GF+TREFL+SLRKPF DI+EPKF+FA+KFNALEL
Sbjct: 284 YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343
Query: 371 DDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKM 430
DDSD++LF+AAII CGDRPGL+NV +E +Q+ I+ L HLQ+NHPD +LFPKLLQKM
Sbjct: 344 DDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKM 403
Query: 431 ADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
ADLRQLVTEHAQ++Q IKKTE++ +LHPLLQEIY+DMY
Sbjct: 404 ADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441
>gi|116284373 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 510 bits (1313), Expect = e-144
Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)
Query: 72 LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
+ PAS P + E PS +L IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 80 VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 139
Query: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 140 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 198
Query: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
+ D + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++ PFVI+DM +L M
Sbjct: 199 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 258
Query: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
E + K + Q+KE +RIF CQ SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 259 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 318
Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 319 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 378
Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
LDDSD+++F+A II GDRPGLLNV IE +Q+ ++ L L L+ NHP+ LF KLLQK
Sbjct: 379 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 438
Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 439 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
Length = 505
Score = 510 bits (1313), Expect = e-144
Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)
Query: 72 LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
+ PAS P + E PS +L IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 108 VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 167
Query: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 168 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 226
Query: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
+ D + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++ PFVI+DM +L M
Sbjct: 227 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 286
Query: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
E + K + Q+KE +RIF CQ SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 287 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 346
Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 347 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 406
Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
LDDSD+++F+A II GDRPGLLNV IE +Q+ ++ L L L+ NHP+ LF KLLQK
Sbjct: 407 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 466
Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 467 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505
>gi|116284368 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 510 bits (1313), Expect = e-144
Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)
Query: 72 LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
+ PAS P + E PS +L IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 80 VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 139
Query: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 140 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 198
Query: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
+ D + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++ PFVI+DM +L M
Sbjct: 199 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 258
Query: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
E + K + Q+KE +RIF CQ SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 259 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 318
Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 319 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 378
Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
LDDSD+++F+A II GDRPGLLNV IE +Q+ ++ L L L+ NHP+ LF KLLQK
Sbjct: 379 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 438
Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 439 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|116284370 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 510 bits (1313), Expect = e-144
Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)
Query: 72 LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
+ PAS P + E PS +L IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 80 VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 139
Query: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 140 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 198
Query: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
+ D + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++ PFVI+DM +L M
Sbjct: 199 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 258
Query: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
E + K + Q+KE +RIF CQ SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 259 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 318
Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 319 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 378
Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
LDDSD+++F+A II GDRPGLLNV IE +Q+ ++ L L L+ NHP+ LF KLLQK
Sbjct: 379 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 438
Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 439 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|29171750 peroxisome proliferative activated receptor, delta
isoform 2 [Homo sapiens]
Length = 361
Score = 442 bits (1136), Expect = e-124
Identities = 218/316 (68%), Positives = 262/316 (82%), Gaps = 2/316 (0%)
Query: 72 LSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIR 131
LS +SSP S+ + G D + G+LN+ECR+CGDKASG+HYGVHACEGCKGFFRRTIR
Sbjct: 45 LSRSSSPPSLLDQLQMGC-DGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIR 103
Query: 132 LKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTC 191
+KL Y+KC+RSCKIQKKNRNKCQYCRF KCL++GMSHNAIRFGRMP +EK KL A +
Sbjct: 104 MKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTAN 163
Query: 192 EHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE 251
E + + ADLK+ +K IY AYLKNFNM K KAR IL+GKAS+ PFVIHD+ETL AE
Sbjct: 164 EGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE 223
Query: 252 KTLVAKLVANGI-QNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK 310
K LV K + NG+ KE V +F+ CQCT+VETV ELTEFAK+IP F++L LNDQVTLLK
Sbjct: 224 KGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK 283
Query: 311 YGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL 370
YGV+EAIFAML+S++NKDG+LVA G+GF+TREFL+SLRKPF DI+EPKF+FA+KFNALEL
Sbjct: 284 YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343
Query: 371 DDSDISLFVAAIICCG 386
DDSD++LF+AAII CG
Sbjct: 344 DDSDLALFIAAIILCG 359
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 183 bits (465), Expect = 3e-46
Identities = 120/394 (30%), Positives = 196/394 (49%), Gaps = 38/394 (9%)
Query: 71 TLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTI 130
T + S+ + +VP P + C +C DK+SGYHYGV ACEGCKGFFRR+I
Sbjct: 50 TAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 109
Query: 131 RLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEIL 189
+ ++Y D++C I K RN+CQYCR KC VGMS ++R R K K +
Sbjct: 110 QKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDR----NKKKKETSKQ 165
Query: 190 TCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM 249
C E TA+L L ++I +A+ + F + GK + N
Sbjct: 166 ECTESYE--MTAELDDLTEKIRKAHQETF------PSLCQLGKYTTN-----------SS 206
Query: 250 AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
A+ + L G+ +K +E+ + + + ++ EFAK +PGF L + DQ+TLL
Sbjct: 207 ADHRVRLDL---GLWDKFSEL---------ATKCIIKIVEFAKRLPGFTGLTIADQITLL 254
Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
K + + + + + + + +G +T + F + + F FA + LE
Sbjct: 255 KAACLDILILRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFTFANQLLPLE 313
Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
+DD++ L A + CGDR L ++K+QE ++ L+++++ P +FPK+L K
Sbjct: 314 MDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMK 373
Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
+ DLR + + A+ V I K E ++ PL+QE+
Sbjct: 374 ITDLRSISAKGAERV-ITLKMEIPGSMPPLIQEM 406
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 180 bits (457), Expect = 2e-45
Identities = 118/396 (29%), Positives = 195/396 (49%), Gaps = 40/396 (10%)
Query: 71 TLSPAS--SPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRR 128
T SPA+ + SS + +VP P + C +C DK+SGYHYGV ACEGCKGFFRR
Sbjct: 55 TPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRR 114
Query: 129 TIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAE 187
+I+ +VY D++C I K RN+CQYCR KC VGMS ++ R+++ K K E
Sbjct: 115 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV------RNDRNKKKKE 168
Query: 188 ILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETL 247
+ E + T ++ L +++ +A+ + F A L +NN
Sbjct: 169 VPKPECSESYTLTPEVGELIEKVRKAHQETF-----PALCQLGKYTTNN----------- 212
Query: 248 CMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVT 307
+ Q ++ ++ S + + + EFAK +PGF L + DQ+T
Sbjct: 213 -------------SSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT 259
Query: 308 LLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
LLK + + + + + + + +G +T + F + + F FA +
Sbjct: 260 LLKAACLDILILRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFANQLLP 318
Query: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLL 427
LE+DD++ L A + CGDR L ++ +QE ++ L+++++ P +FPK+L
Sbjct: 319 LEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKML 378
Query: 428 QKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
K+ DLR + + A+ V I K E ++ PL+QE+
Sbjct: 379 MKITDLRSISAKGAERV-ITLKMEIPGSMPPLIQEM 413
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 180 bits (457), Expect = 2e-45
Identities = 118/396 (29%), Positives = 195/396 (49%), Gaps = 40/396 (10%)
Query: 71 TLSPAS--SPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRR 128
T SPA+ + SS + +VP P + C +C DK+SGYHYGV ACEGCKGFFRR
Sbjct: 55 TPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRR 114
Query: 129 TIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAE 187
+I+ +VY D++C I K RN+CQYCR KC VGMS ++ R+++ K K E
Sbjct: 115 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV------RNDRNKKKKE 168
Query: 188 ILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETL 247
+ E + T ++ L +++ +A+ + F A L +NN
Sbjct: 169 VPKPECSESYTLTPEVGELIEKVRKAHQETF-----PALCQLGKYTTNN----------- 212
Query: 248 CMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVT 307
+ Q ++ ++ S + + + EFAK +PGF L + DQ+T
Sbjct: 213 -------------SSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT 259
Query: 308 LLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
LLK + + + + + + + +G +T + F + + F FA +
Sbjct: 260 LLKAACLDILILRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFANQLLP 318
Query: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLL 427
LE+DD++ L A + CGDR L ++ +QE ++ L+++++ P +FPK+L
Sbjct: 319 LEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKML 378
Query: 428 QKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
K+ DLR + + A+ V I K E ++ PL+QE+
Sbjct: 379 MKITDLRSISAKGAERV-ITLKMEIPGSMPPLIQEM 413
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 180 bits (457), Expect = 2e-45
Identities = 118/394 (29%), Positives = 199/394 (50%), Gaps = 38/394 (9%)
Query: 71 TLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTI 130
+L + S+ + +VP S P + C +C DK+SGYHYGV +CEGCKGFFRR+I
Sbjct: 48 SLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSI 107
Query: 131 RLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEIL 189
+ +VY D++C I K RN+CQYCR KC VGMS A+R R +K ++K E
Sbjct: 108 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR--NKKKKEVKEEGS 165
Query: 190 TCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM 249
+++ + L+ L ++ +A+ + F + GK + N
Sbjct: 166 PDSYEL----SPQLEELITKVSKAHQETF------PSLCQLGKYTTN-----------SS 204
Query: 250 AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
A+ + L G+ +K +E+ + + + ++ EFAK +PGF L + DQ+TLL
Sbjct: 205 ADHRVQLDL---GLWDKFSEL---------ATKCIIKIVEFAKRLPGFTGLSIADQITLL 252
Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
K + + + + + + + +G +T + F + + F FA + LE
Sbjct: 253 KAACLDILMLRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFAGQLLPLE 311
Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
+DD++ L A + CGDR L ++K+QE ++ LRL+ + P ++FP++L K
Sbjct: 312 MDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK 371
Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
+ DLR + T+ A+ I K E + PL++E+
Sbjct: 372 ITDLRGISTKGAERA-ITLKMEIPGPMPPLIREM 404
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 179 bits (453), Expect = 6e-45
Identities = 117/386 (30%), Positives = 196/386 (50%), Gaps = 38/386 (9%)
Query: 79 SSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD- 137
S+ + +VP S P + C +C DK+SGYHYGV +CEGCKGFFRR+I+ +VY
Sbjct: 67 STSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTC 126
Query: 138 KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIED 197
D++C I K RN+CQYCR KC VGMS A+R R +K ++K E +++
Sbjct: 127 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR--NKKKKEVKEEGSPDSYEL-- 182
Query: 198 SETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAK 257
+ L+ L ++ +A+ + F + GK + N A+ +
Sbjct: 183 --SPQLEELITKVSKAHQETF------PSLCQLGKYTTN-----------SSADHRVQLD 223
Query: 258 LVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAI 317
L G+ +K +E+ + + + ++ EFAK +PGF L + DQ+TLLK + +
Sbjct: 224 L---GLWDKFSEL---------ATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDIL 271
Query: 318 FAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISL 377
+ + + + + +G +T + F + + F FA + LE+DD++ L
Sbjct: 272 MLRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGL 330
Query: 378 FVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLV 437
A + CGDR L ++K+QE ++ LRL+ + P ++FP++L K+ DLR +
Sbjct: 331 LSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGIS 390
Query: 438 TEHAQLVQIIKKTESDAALHPLLQEI 463
T+ A+ I K E + PL++E+
Sbjct: 391 TKGAERA-ITLKMEIPGPMPPLIREM 415
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 178 bits (452), Expect = 8e-45
Identities = 114/386 (29%), Positives = 189/386 (48%), Gaps = 38/386 (9%)
Query: 79 SSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD- 137
SS + +VP P + C +C DK+SGYHYGV ACEGCKGFFRR+I+ +VY
Sbjct: 60 SSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTC 119
Query: 138 KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIED 197
D++C I K RN+CQYCR KC VGMS ++ R+++ K K E+ E
Sbjct: 120 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV------RNDRNKKKKEVPKPECSESY 173
Query: 198 SETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAK 257
+ T ++ L +++ +A+ + F A L +NN
Sbjct: 174 TLTPEVGELIEKVRKAHQETF-----PALCQLGKYTTNN--------------------- 207
Query: 258 LVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAI 317
+ Q ++ ++ S + + + EFAK +PGF L + DQ+TLLK + +
Sbjct: 208 ---SSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264
Query: 318 FAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISL 377
+ + + + + +G +T + F + + F FA + LE+DD++ L
Sbjct: 265 ILRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGL 323
Query: 378 FVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLV 437
A + CGDR L ++ +QE ++ L+++++ P +FPK+L K+ DLR +
Sbjct: 324 LSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSIS 383
Query: 438 TEHAQLVQIIKKTESDAALHPLLQEI 463
+ A+ V I K E ++ PL+QE+
Sbjct: 384 AKGAERV-ITLKMEIPGSMPPLIQEM 408
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 156 bits (395), Expect = 3e-38
Identities = 121/428 (28%), Positives = 190/428 (44%), Gaps = 66/428 (15%)
Query: 62 GSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGAL--NIECRICGDKASGYHYGVHAC 119
G + + T L+ A PS T + P + P+ + N C +CGDKASG+HY V +C
Sbjct: 12 GLEAAEPTALLTRAEPPSEPT-EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSC 70
Query: 120 EGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
EGCKGFFRR++ +K + C C + R KCQ CR KC GM +
Sbjct: 71 EGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 129
Query: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNP 237
R +K K + E E A SL R +++P
Sbjct: 130 RLKKLKRQEE-----------EQAHATSLPPR------------------------ASSP 154
Query: 238 PFVIHDM--ETLCMAEKTLVAKLVAN-----------------GIQNKEAEVRIFHCCQC 278
P ++ + E L M EK + A+ N ++EA + F
Sbjct: 155 PQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTE 214
Query: 279 TSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF 338
++ +V E+ +FAK +PGF L DQ+ LLK E + S N + + F
Sbjct: 215 LAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDF 274
Query: 339 I--TREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH 396
+F K+ + + + P F+F+ N L+L+D++ +L +A I DRP + +
Sbjct: 275 SYNREDFAKAGLQ--VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQ 332
Query: 397 IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL 456
+E++Q V L ++ +HP D +FP++L K+ LR L + H++ Q+ D L
Sbjct: 333 VERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSE--QVFALRLQDKKL 390
Query: 457 HPLLQEIY 464
PLL EI+
Sbjct: 391 PPLLSEIW 398
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 156 bits (395), Expect = 3e-38
Identities = 121/428 (28%), Positives = 190/428 (44%), Gaps = 66/428 (15%)
Query: 62 GSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGAL--NIECRICGDKASGYHYGVHAC 119
G + + T L+ A PS T + P + P+ + N C +CGDKASG+HY V +C
Sbjct: 57 GLEAAEPTALLTRAEPPSEPT-EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSC 115
Query: 120 EGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
EGCKGFFRR++ +K + C C + R KCQ CR KC GM +
Sbjct: 116 EGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 174
Query: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNP 237
R +K K + E E A SL R +++P
Sbjct: 175 RLKKLKRQEE-----------EQAHATSLPPR------------------------ASSP 199
Query: 238 PFVIHDM--ETLCMAEKTLVAKLVAN-----------------GIQNKEAEVRIFHCCQC 278
P ++ + E L M EK + A+ N ++EA + F
Sbjct: 200 PQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTE 259
Query: 279 TSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF 338
++ +V E+ +FAK +PGF L DQ+ LLK E + S N + + F
Sbjct: 260 LAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDF 319
Query: 339 I--TREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH 396
+F K+ + + + P F+F+ N L+L+D++ +L +A I DRP + +
Sbjct: 320 SYNREDFAKAGLQ--VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQ 377
Query: 397 IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL 456
+E++Q V L ++ +HP D +FP++L K+ LR L + H++ Q+ D L
Sbjct: 378 VERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSE--QVFALRLQDKKL 435
Query: 457 HPLLQEIY 464
PLL EI+
Sbjct: 436 PPLLSEIW 443
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 154 bits (389), Expect = 2e-37
Identities = 127/448 (28%), Positives = 199/448 (44%), Gaps = 67/448 (14%)
Query: 28 LQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVP 87
L +G+ + S SG+ L + P S +V+ S +SS P +P
Sbjct: 63 LNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVN---SVSSSEDIKPLPGLP 119
Query: 88 GSVD-----ESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDR 141
G + SP + C ICGD++SG HYGV++CEGCKGFF+RTIR L+Y + ++
Sbjct: 120 GIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNK 179
Query: 142 SCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETA 201
C I K+ RN+CQYCR+ KCL +GM A++ R E+A+ +AE T H ED
Sbjct: 180 DCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGH--EDM--- 234
Query: 202 DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVAN 261
+E + AE + K +
Sbjct: 235 -----------------------------------------PVERILEAELAVEPKTESY 253
Query: 262 GIQNKEAEVR--IFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA 319
G N E + + C + T L E+AK IP F++L L DQV LL+ G E + A
Sbjct: 254 GDMNMENSTNDPVTNICHAADKQLFT-LVEWAKRIPHFSDLTLEDQVILLRAGWNELLIA 312
Query: 320 MLS--SVMNKDGMLVAYG-NGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDIS 376
S SV +DG+L+A G + + + F ++ + K +++D S++
Sbjct: 313 SFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLT---ELVSKMKDMQMDKSELG 369
Query: 377 LFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL 436
A ++ D GL N +E ++E + L + + +P+ F KLL ++ LR +
Sbjct: 370 CLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSI 429
Query: 437 ---VTEHAQLVQIIKKTESDAALHPLLQ 461
EH ++I T D L +L+
Sbjct: 430 GLKCLEHLFFFKLIGDTPIDTFLMEMLE 457
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 151 bits (382), Expect = 1e-36
Identities = 115/411 (27%), Positives = 193/411 (46%), Gaps = 65/411 (15%)
Query: 68 ITDTLSPASSPSSVTYPV-------VPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120
++ ++P SS + P+ VP + + C ICGD++SG HYGV++CE
Sbjct: 94 LSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCE 153
Query: 121 GCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRS 179
GCKGFF+RT+R L Y + ++ C I K+ RN+CQYCR+ KCL++GM A++ R
Sbjct: 154 GCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGK 213
Query: 180 EKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYL--KNFNMNKVKARVILSGKASNNP 237
++ E+++E + +A+ +RI EA L + V+A + L+ + N+P
Sbjct: 214 DRN---------ENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDP 264
Query: 238 PFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGF 297
+ + CQ + T L E+AK IP F
Sbjct: 265 ----------------------------------VTNICQAADKQLFT-LVEWAKRIPHF 289
Query: 298 ANLDLNDQVTLLKYGVYEAIFAMLS--SVMNKDGMLVAYGNGFITREFLKS--LRKPFCD 353
+ L L+DQV LL+ G E + A S S+ KDG+L+A G + R S + F
Sbjct: 290 SELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGL-HVHRNSAHSAGVGAIFDR 348
Query: 354 IMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQ 413
++ + K +++D +++ A ++ D GL N +E ++E + L + +
Sbjct: 349 VLT---ELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCK 405
Query: 414 SNHPDDIFLFPKLLQKMADLRQL---VTEHAQLVQIIKKTESDAALHPLLQ 461
+P+ F KLL ++ LR + EH ++I T D L +L+
Sbjct: 406 HKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 143 bits (361), Expect = 3e-34
Identities = 120/415 (28%), Positives = 183/415 (44%), Gaps = 66/415 (15%)
Query: 59 SCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHA 118
S PG D P + P PG GA C ICGD++SG HYGV++
Sbjct: 167 SLPGGGSGPPEDVKPPVLGVRGLHCPPPPGG-----PGAGKRLCAICGDRSSGKHYGVYS 221
Query: 119 CEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
CEGCKGFF+RTIR L Y + ++ C + K+ RN+CQYCR+ KCL+ GM A++ R
Sbjct: 222 CEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQR 281
Query: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYL----KNFNMNKVKARVILSGKA 233
+K + D E + A + RI EA L K+ + SG +
Sbjct: 282 GKDK----------DGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSS 331
Query: 234 SNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKA 293
N+P + + CQ + T L E+AK
Sbjct: 332 PNDP----------------------------------VTNICQAADKQLFT-LVEWAKR 356
Query: 294 IPGFANLDLNDQVTLLKYGVYEAIFAMLS--SVMNKDGMLVAYGNGFITREFLKS--LRK 349
IP F++L L+DQV LL+ G E + A S S+ +DG+L+A G + R S +
Sbjct: 357 IPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGL-HVHRNSAHSAGVGA 415
Query: 350 PFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLR 409
F ++ + K + +D +++ A I+ D GL N +E ++E + L
Sbjct: 416 IFDRVLT---ELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLE 472
Query: 410 LHLQSNHPDDIFLFPKLLQKMADLRQL---VTEHAQLVQIIKKTESDAALHPLLQ 461
+ + +P+ F KLL ++ LR + EH ++I T D L +L+
Sbjct: 473 TYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 137 bits (345), Expect = 2e-32
Identities = 113/405 (27%), Positives = 179/405 (44%), Gaps = 70/405 (17%)
Query: 74 PASSPSSVTY-----PVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRR 128
PAS+P+ P PGS + +IEC +CGDK+SG HYG CEGCK FF+R
Sbjct: 48 PASTPAQTAAGGQGGPGGPGS--DKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKR 105
Query: 129 TIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEK-----A 182
++R L Y + +R+C I + +RN+CQYCR KCL VGM A++ GRMP ++ A
Sbjct: 106 SVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFA 165
Query: 183 KLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIH 242
+ L C +YL + ++A P+
Sbjct: 166 LTNGDPLNC--------------------HSYLSGYISLLLRAE-----------PYPTS 194
Query: 243 DMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDL 302
+ CM ++ GI+N C+ + + E+A+ IP F +L +
Sbjct: 195 RFGSQCMQPNNIM------GIEN---------ICE-LAARMLFSAVEWARNIPFFPDLQI 238
Query: 303 NDQVTLLKYGVYEAIF----AMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPK 358
DQV LL+ + +F A S ++ +L A G F D +
Sbjct: 239 TDQVALLRL-TWSELFVLNAAQCSMPLHVAPLLAA--AGLHASPMSADRVVAFMDHIRIF 295
Query: 359 FDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPD 418
+ K AL +D ++ S A ++ D GL +V H+E +QE L +++S +P+
Sbjct: 296 QEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPN 355
Query: 419 DIFLFPKLLQKMADLRQL---VTEHAQLVQIIKKTESDAALHPLL 460
F KLL ++ LR + V E V+++ KT + + +L
Sbjct: 356 QPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 400
>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
sapiens]
Length = 614
Score = 137 bits (344), Expect = 3e-32
Identities = 72/155 (46%), Positives = 98/155 (63%), Gaps = 21/155 (13%)
Query: 38 SQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDT--LSPASSPSSVTYPVVPGSVDESPS 95
S S SS SF Y GS PGS + D+ +SP+ S S++T
Sbjct: 83 SSSSSSSSSSSF------YNGSPPGSLQVAMEDSSRVSPSKSTSNIT-----------KL 125
Query: 96 GALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKC 153
+ + C++CGD ASG+HYGVHACEGCKGFFRR+I+ + Y +C + +C I + NRN+C
Sbjct: 126 NGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRC 185
Query: 154 QYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEI 188
Q CRF KCLSVGMS +A+RFGR+P+ EK ++ AE+
Sbjct: 186 QQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEM 220
Score = 100 bits (248), Expect = 4e-21
Identities = 57/160 (35%), Positives = 90/160 (56%), Gaps = 3/160 (1%)
Query: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMN-KDGMLVAYGNGFITRE 342
V E+ EFAK IPGF +L +DQVTLLK G +E + +S+ N KD ++ + +
Sbjct: 447 VREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQ 506
Query: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
L ++ D++ FDF+ K N+L L + ++ LF A ++ DR G+ N +E++QE
Sbjct: 507 ELGAMGMG--DLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQE 564
Query: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
++ LR + N P + F KLL K+ DLR L H++
Sbjct: 565 TLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSE 604
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 137 bits (344), Expect = 3e-32
Identities = 112/411 (27%), Positives = 177/411 (43%), Gaps = 63/411 (15%)
Query: 65 GSVITDTLSPASSPSSVTYPVVPGSVDESPSGA----LNIECRICGDKASGYHYGVHACE 120
GS T P + P G + P G+ +IEC +CGDK+SG HYG CE
Sbjct: 45 GSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCE 104
Query: 121 GCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRS 179
GCK FF+R++R L Y + +R+C I + +RN+CQYCR KCL VGM A++ GRMP +
Sbjct: 105 GCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPT 164
Query: 180 EKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKAS---NN 236
+ + + N + + LSG S
Sbjct: 165 QPNPGQYALT-----------------------------NGDPLNGHCYLSGYISLLLRA 195
Query: 237 PPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPG 296
P+ + CM ++ GI+N C+ + + E+A+ IP
Sbjct: 196 EPYPTSRYGSQCMQPNNIM------GIEN---------ICE-LAARLLFSAVEWARNIPF 239
Query: 297 FANLDLNDQVTLLKYGVYEAIF----AMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFC 352
F +L + DQV+LL+ + +F A S ++ +L A G F
Sbjct: 240 FPDLQITDQVSLLRL-TWSELFVLNAAQCSMPLHVAPLLAA--AGLHASPMSADRVVAFM 296
Query: 353 DIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHL 412
D + + K AL +D ++ S A ++ D GL + HIE +QE L ++
Sbjct: 297 DHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYV 356
Query: 413 QSNHPDDIFLFPKLLQKMADLRQL---VTEHAQLVQIIKKTESDAALHPLL 460
+S +P+ F KLL ++ LR + V E V+++ KT + + +L
Sbjct: 357 RSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 136 bits (343), Expect = 4e-32
Identities = 106/400 (26%), Positives = 178/400 (44%), Gaps = 38/400 (9%)
Query: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHK 160
C +CGD+A+G+H+ CEGCKGFFRR+++ K ++ + C+I K NR CQ CR +
Sbjct: 24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKR 83
Query: 161 CLSVGMSHNAI---------RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIY 211
C+ +GM I R + R E+ LK + + + A L + Y
Sbjct: 84 CVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTY 143
Query: 212 EAYLKNFNMNKVKARVILSGKA------SNNPPFVIHDMETLC---------MAEKTLVA 256
+ +F + RV G + S + P D + C M + + +
Sbjct: 144 DPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFS 203
Query: 257 KLVANGIQNKEAEVRIF--------HCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL 308
L + + + V + H S ++ ++ FAK IPGF +L DQ+ L
Sbjct: 204 NLDLSEEDSDDPSVTLELSQLSMLPHLADLVSY-SIQKVIGFAKMIPGFRDLTSEDQIVL 262
Query: 309 LKYGVYEAIFAMLSSVMNKDGMLVAYGN-GFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
LK E I + D M GN + R + +++EP F +
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
Query: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNH--PDDIFLFPK 425
L L + + L +A I DRPG+ + IE +Q+ + + L+ +++ H P L+ K
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
Query: 426 LLQKMADLRQLVTEHAQLVQIIK-KTESDAALHPLLQEIY 464
++QK+ADLR L EH++ + + + E L PL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 136 bits (343), Expect = 4e-32
Identities = 106/400 (26%), Positives = 178/400 (44%), Gaps = 38/400 (9%)
Query: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHK 160
C +CGD+A+G+H+ CEGCKGFFRR+++ K ++ + C+I K NR CQ CR +
Sbjct: 24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKR 83
Query: 161 CLSVGMSHNAI---------RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIY 211
C+ +GM I R + R E+ LK + + + A L + Y
Sbjct: 84 CVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTY 143
Query: 212 EAYLKNFNMNKVKARVILSGKA------SNNPPFVIHDMETLC---------MAEKTLVA 256
+ +F + RV G + S + P D + C M + + +
Sbjct: 144 DPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFS 203
Query: 257 KLVANGIQNKEAEVRIF--------HCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL 308
L + + + V + H S ++ ++ FAK IPGF +L DQ+ L
Sbjct: 204 NLDLSEEDSDDPSVTLELSQLSMLPHLADLVSY-SIQKVIGFAKMIPGFRDLTSEDQIVL 262
Query: 309 LKYGVYEAIFAMLSSVMNKDGMLVAYGN-GFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
LK E I + D M GN + R + +++EP F +
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
Query: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNH--PDDIFLFPK 425
L L + + L +A I DRPG+ + IE +Q+ + + L+ +++ H P L+ K
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
Query: 426 LLQKMADLRQLVTEHAQLVQIIK-KTESDAALHPLLQEIY 464
++QK+ADLR L EH++ + + + E L PL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
Length = 504
Score = 129 bits (324), Expect = 6e-30
Identities = 55/100 (55%), Positives = 76/100 (76%), Gaps = 2/100 (2%)
Query: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFH 159
C++CGD ASG+HYGVHACEGCKGFFRR+I+ + Y KC + +C I + NRN+CQ CRF
Sbjct: 28 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87
Query: 160 KCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
KCLSVGMS +A+RFGR+P+ EK ++ E+ + + +S+
Sbjct: 88 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 127
Score = 111 bits (277), Expect = 2e-24
Identities = 60/160 (37%), Positives = 94/160 (58%), Gaps = 3/160 (1%)
Query: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF-ITRE 342
V E+ EFAK IPGF +L +DQV LLK G +E + +S+ + V + +G + +
Sbjct: 338 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 397
Query: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
L S+ D++ F+F+ K NAL+L D ++SLF A ++ DR G+ NV +E +QE
Sbjct: 398 DLHSMGAG--DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 455
Query: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
++ LR + NHP++ +F KLL K+ DLR L H++
Sbjct: 456 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSE 495
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 129 bits (324), Expect = 6e-30
Identities = 91/324 (28%), Positives = 156/324 (48%), Gaps = 37/324 (11%)
Query: 140 DRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
D++C I K RN+CQYCR KC VGMS ++R R K K + C E
Sbjct: 8 DKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDR----NKKKKETSKQECTESYE--M 61
Query: 200 TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLV 259
TA+L L ++I +A+ + F + GK + N A+ + L
Sbjct: 62 TAELDDLTEKIRKAHQETF------PSLCQLGKYTTNSS-----------ADHRVRLDL- 103
Query: 260 ANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA 319
G+ +K +E+ + + + ++ EFAK +PGF L + DQ+TLLK + +
Sbjct: 104 --GLWDKFSEL---------ATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILIL 152
Query: 320 MLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFV 379
+ + + + + +G +T + F + + F FA + LE+DD++ L
Sbjct: 153 RICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLS 211
Query: 380 AAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE 439
A + CGDR L ++K+QE ++ L+++++ P +FPK+L K+ DLR + +
Sbjct: 212 AICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAK 271
Query: 440 HAQLVQIIKKTESDAALHPLLQEI 463
A+ V I K E ++ PL+QE+
Sbjct: 272 GAERV-ITLKMEIPGSMPPLIQEM 294
>gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
Length = 579
Score = 129 bits (324), Expect = 6e-30
Identities = 55/100 (55%), Positives = 76/100 (76%), Gaps = 2/100 (2%)
Query: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFH 159
C++CGD ASG+HYGVHACEGCKGFFRR+I+ + Y KC + +C I + NRN+CQ CRF
Sbjct: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162
Query: 160 KCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
KCLSVGMS +A+RFGR+P+ EK ++ E+ + + +S+
Sbjct: 163 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 202
Score = 111 bits (277), Expect = 2e-24
Identities = 60/160 (37%), Positives = 94/160 (58%), Gaps = 3/160 (1%)
Query: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF-ITRE 342
V E+ EFAK IPGF +L +DQV LLK G +E + +S+ + V + +G + +
Sbjct: 413 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 472
Query: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
L S+ D++ F+F+ K NAL+L D ++SLF A ++ DR G+ NV +E +QE
Sbjct: 473 DLHSMGAG--DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 530
Query: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
++ LR + NHP++ +F KLL K+ DLR L H++
Sbjct: 531 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSE 570
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 125 bits (313), Expect = 1e-28
Identities = 109/391 (27%), Positives = 171/391 (43%), Gaps = 64/391 (16%)
Query: 86 VPGSVDESPSGALNIE----------CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLV 135
V S D SPS N+ C ICGD+A+G HYG +C+GCKGFFRR++R +
Sbjct: 12 VESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 71
Query: 136 YD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHD 194
Y + R C + K RN+C+YCR KC GM A++ R I T
Sbjct: 72 YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNER----------DRISTRRSS 121
Query: 195 IEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTL 254
EDS + +L + +V +R I S + N +
Sbjct: 122 YEDSSLPSINALLQA------------EVLSRQITSPVSGIN---------------GDI 154
Query: 255 VAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK--YG 312
AK +A+ I C+ + E + L E+AK IP F L L+DQV LL+ G
Sbjct: 155 RAKKIAS----------IADVCE-SMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203
Query: 313 VYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDD 372
+ + A S++ KD +L+ GN +I L + + + + F L++DD
Sbjct: 204 EHLLLGATKRSMVFKDVLLL--GNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDD 261
Query: 373 SDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMAD 432
++ + A I D GL + G I++++ + L ++ D F +LL +
Sbjct: 262 NEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPT 321
Query: 433 LRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
L+ + + + +Q I K A + LLQE+
Sbjct: 322 LQSITWQMIEQIQFI-KLFGMAKIDNLLQEM 351
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 120 bits (300), Expect = 3e-27
Identities = 121/478 (25%), Positives = 196/478 (41%), Gaps = 61/478 (12%)
Query: 5 ESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSD 64
E LC +S + ++S S E + ++ S+ S G Y + G
Sbjct: 18 EELLCRMSNKDR-HIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQ 76
Query: 65 GSVITDTLSPA------SSPSSVTYPVVPGSVDESPSGALNIE--------CRICGDKAS 110
+ + L P+ S P Y ++ E P C +CGD AS
Sbjct: 77 NGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIAS 136
Query: 111 GYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHN 169
GYHYGV +CE CK FF+RTI+ + Y C+I K+ R CQ CRF KCL VGM
Sbjct: 137 GYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKE 196
Query: 170 AIRFGRMPRSEKAKLKAEILTCEHDIEDSE--TADLKSLAKRIYEAYLKNFNMNKVKARV 227
+R R+ R + K K I D E+S L AK+ Y NK+ + +
Sbjct: 197 GVRLDRV-RGGRQKYKRRI-----DAENSPYLNPQLVQPAKKPY---------NKIVSHL 241
Query: 228 ILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTEL 287
+++ P I+ M + + + A + ++E V I
Sbjct: 242 LVA------EPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVII--------------- 280
Query: 288 TEFAKAIPGFANLDLNDQVTLLKYGVYEAIF--AMLSSVMNKDGMLVAYGNGFITREFLK 345
+AK IPGF+ L L DQ++LL+ E + + S+ +D ++ Y + +I E
Sbjct: 281 -GWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELV--YADDYIMDEDQS 337
Query: 346 SLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIV 405
L D+ K+ +++L+ + A + D + +V ++K+Q+ +
Sbjct: 338 KLAG-LLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLH 396
Query: 406 HVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
L+ + H +D K+L + LRQ T+ Q I K E +H L E+
Sbjct: 397 EALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNI-KLEGKVPMHKLFLEM 453
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 119 bits (297), Expect = 8e-27
Identities = 117/464 (25%), Positives = 190/464 (40%), Gaps = 60/464 (12%)
Query: 19 LESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPA--- 75
++S S E + ++ S+ S G Y + G + + L P+
Sbjct: 8 IDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPI 67
Query: 76 ---SSPSSVTYPVVPGSVDESPSGALNIE--------CRICGDKASGYHYGVHACEGCKG 124
S P Y ++ E P C +CGD ASGYHYGV +CE CK
Sbjct: 68 LGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKA 127
Query: 125 FFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAK 183
FF+RTI+ + Y C+I K+ R CQ CRF KCL VGM +R R+ R + K
Sbjct: 128 FFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV-RGGRQK 186
Query: 184 LKAEILTCEHDIEDSE--TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVI 241
K I D E+S L AK+ Y NK+ + ++++ P I
Sbjct: 187 YKRRI-----DAENSPYLNPQLVQPAKKPY---------NKIVSHLLVA------EPEKI 226
Query: 242 HDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD 301
+ M + + + A + ++E V I +AK IPGF+ L
Sbjct: 227 YAMPDPTVPDSDIKALTTLCDLADRELVVII----------------GWAKHIPGFSTLS 270
Query: 302 LNDQVTLLKYGVYEAIF--AMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF 359
L DQ++LL+ E + + S+ +D ++ Y + +I E L D+
Sbjct: 271 LADQMSLLQSAWMEILILGVVYRSLSFEDELV--YADDYIMDEDQSKLAG-LLDLNNAIL 327
Query: 360 DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDD 419
K+ +++L+ + A + D + +V ++K+Q+ + L+ + H +D
Sbjct: 328 QLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMED 387
Query: 420 IFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
K+L + LRQ T+ Q I K E +H L E+
Sbjct: 388 PRRAGKMLMTLPLLRQTSTKAVQHFYNI-KLEGKVPMHKLFLEM 430
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,420,130
Number of Sequences: 37866
Number of extensions: 776248
Number of successful extensions: 2696
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2297
Number of HSP's gapped (non-prelim): 224
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.