Guide to the Human Genome
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Search of human proteins with 50348666

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
         (468 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50348666 peroxisome proliferative activated receptor, alpha [...   947   0.0  
gi|7549811 peroxisome proliferative activated receptor, alpha [H...   947   0.0  
gi|5453940 peroxisome proliferative activated receptor, delta is...   560   e-160
gi|116284373 peroxisome proliferative activated receptor gamma i...   510   e-144
gi|20336229 peroxisome proliferative activated receptor gamma is...   510   e-144
gi|116284368 peroxisome proliferative activated receptor gamma i...   510   e-144
gi|116284370 peroxisome proliferative activated receptor gamma i...   510   e-144
gi|29171750 peroxisome proliferative activated receptor, delta i...   442   e-124
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]     183   3e-46
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]   180   2e-45
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]     180   2e-45
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]   180   2e-45
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]     179   6e-45
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]    178   8e-45
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso...   156   3e-38
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso...   156   3e-38
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]        154   2e-37
gi|4506755 retinoid X receptor, alpha [Homo sapiens]                  151   1e-36
gi|11415052 retinoid X receptor, beta [Homo sapiens]                  143   3e-34
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof...   137   2e-32
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom...   137   3e-32
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo...   137   3e-32
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ...   136   4e-32
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s...   136   4e-32
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso...   129   6e-30
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]      129   6e-30
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso...   129   6e-30
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa...   125   1e-28
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi...   120   3e-27
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi...   119   8e-27

>gi|50348666 peroxisome proliferative activated receptor, alpha
           [Homo sapiens]
          Length = 468

 Score =  947 bits (2448), Expect = 0.0
 Identities = 468/468 (100%), Positives = 468/468 (100%)

Query: 1   MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC 60
           MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
Sbjct: 1   MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC 60

Query: 61  PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120
           PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
Sbjct: 61  PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120

Query: 121 GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE 180
           GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
Sbjct: 121 GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE 180

Query: 181 KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV 240
           KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
Sbjct: 181 KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV 240

Query: 241 IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL 300
           IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
Sbjct: 241 IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL 300

Query: 301 DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD 360
           DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
Sbjct: 301 DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD 360

Query: 361 FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI 420
           FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
Sbjct: 361 FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI 420

Query: 421 FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
           FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Sbjct: 421 FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468


>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
           sapiens]
          Length = 468

 Score =  947 bits (2448), Expect = 0.0
 Identities = 468/468 (100%), Positives = 468/468 (100%)

Query: 1   MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC 60
           MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
Sbjct: 1   MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC 60

Query: 61  PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120
           PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
Sbjct: 61  PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120

Query: 121 GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE 180
           GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
Sbjct: 121 GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE 180

Query: 181 KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV 240
           KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
Sbjct: 181 KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV 240

Query: 241 IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL 300
           IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
Sbjct: 241 IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL 300

Query: 301 DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD 360
           DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
Sbjct: 301 DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD 360

Query: 361 FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI 420
           FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
Sbjct: 361 FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI 420

Query: 421 FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
           FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Sbjct: 421 FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468


>gi|5453940 peroxisome proliferative activated receptor, delta
           isoform 1 [Homo sapiens]
          Length = 441

 Score =  560 bits (1444), Expect = e-160
 Identities = 275/398 (69%), Positives = 332/398 (83%), Gaps = 2/398 (0%)

Query: 72  LSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIR 131
           LS +SSP S+   +  G  D +  G+LN+ECR+CGDKASG+HYGVHACEGCKGFFRRTIR
Sbjct: 45  LSRSSSPPSLLDQLQMGC-DGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIR 103

Query: 132 LKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTC 191
           +KL Y+KC+RSCKIQKKNRNKCQYCRF KCL++GMSHNAIRFGRMP +EK KL A +   
Sbjct: 104 MKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTAN 163

Query: 192 EHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE 251
           E    + + ADLK+ +K IY AYLKNFNM K KAR IL+GKAS+  PFVIHD+ETL  AE
Sbjct: 164 EGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE 223

Query: 252 KTLVAKLVANGIQN-KEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK 310
           K LV K + NG+   KE  V +F+ CQCT+VETV ELTEFAK+IP F++L LNDQVTLLK
Sbjct: 224 KGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK 283

Query: 311 YGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL 370
           YGV+EAIFAML+S++NKDG+LVA G+GF+TREFL+SLRKPF DI+EPKF+FA+KFNALEL
Sbjct: 284 YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343

Query: 371 DDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKM 430
           DDSD++LF+AAII CGDRPGL+NV  +E +Q+ I+  L  HLQ+NHPD  +LFPKLLQKM
Sbjct: 344 DDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKM 403

Query: 431 ADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
           ADLRQLVTEHAQ++Q IKKTE++ +LHPLLQEIY+DMY
Sbjct: 404 ADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441


>gi|116284373 peroxisome proliferative activated receptor gamma
           isoform 1 [Homo sapiens]
          Length = 477

 Score =  510 bits (1313), Expect = e-144
 Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)

Query: 72  LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
           + PAS P       +     E PS +L  IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 80  VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 139

Query: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
           RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 140 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 198

Query: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
            + D  + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++  PFVI+DM +L M 
Sbjct: 199 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 258

Query: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
           E  +  K +     Q+KE  +RIF  CQ  SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 259 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 318

Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
           KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 319 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 378

Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
           LDDSD+++F+A II  GDRPGLLNV  IE +Q+ ++  L L L+ NHP+   LF KLLQK
Sbjct: 379 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 438

Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
           M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 439 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477


>gi|20336229 peroxisome proliferative activated receptor gamma
           isoform 2 [Homo sapiens]
          Length = 505

 Score =  510 bits (1313), Expect = e-144
 Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)

Query: 72  LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
           + PAS P       +     E PS +L  IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 108 VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 167

Query: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
           RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 168 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 226

Query: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
            + D  + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++  PFVI+DM +L M 
Sbjct: 227 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 286

Query: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
           E  +  K +     Q+KE  +RIF  CQ  SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 287 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 346

Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
           KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 347 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 406

Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
           LDDSD+++F+A II  GDRPGLLNV  IE +Q+ ++  L L L+ NHP+   LF KLLQK
Sbjct: 407 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 466

Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
           M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 467 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505


>gi|116284368 peroxisome proliferative activated receptor gamma
           isoform 1 [Homo sapiens]
          Length = 477

 Score =  510 bits (1313), Expect = e-144
 Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)

Query: 72  LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
           + PAS P       +     E PS +L  IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 80  VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 139

Query: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
           RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 140 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 198

Query: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
            + D  + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++  PFVI+DM +L M 
Sbjct: 199 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 258

Query: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
           E  +  K +     Q+KE  +RIF  CQ  SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 259 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 318

Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
           KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 319 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 378

Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
           LDDSD+++F+A II  GDRPGLLNV  IE +Q+ ++  L L L+ NHP+   LF KLLQK
Sbjct: 379 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 438

Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
           M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 439 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477


>gi|116284370 peroxisome proliferative activated receptor gamma
           isoform 1 [Homo sapiens]
          Length = 477

 Score =  510 bits (1313), Expect = e-144
 Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)

Query: 72  LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
           + PAS P       +     E PS +L  IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 80  VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 139

Query: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
           RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 140 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 198

Query: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
            + D  + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++  PFVI+DM +L M 
Sbjct: 199 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 258

Query: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
           E  +  K +     Q+KE  +RIF  CQ  SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 259 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 318

Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
           KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 319 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 378

Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
           LDDSD+++F+A II  GDRPGLLNV  IE +Q+ ++  L L L+ NHP+   LF KLLQK
Sbjct: 379 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 438

Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
           M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 439 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477


>gi|29171750 peroxisome proliferative activated receptor, delta
           isoform 2 [Homo sapiens]
          Length = 361

 Score =  442 bits (1136), Expect = e-124
 Identities = 218/316 (68%), Positives = 262/316 (82%), Gaps = 2/316 (0%)

Query: 72  LSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIR 131
           LS +SSP S+   +  G  D +  G+LN+ECR+CGDKASG+HYGVHACEGCKGFFRRTIR
Sbjct: 45  LSRSSSPPSLLDQLQMGC-DGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIR 103

Query: 132 LKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTC 191
           +KL Y+KC+RSCKIQKKNRNKCQYCRF KCL++GMSHNAIRFGRMP +EK KL A +   
Sbjct: 104 MKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTAN 163

Query: 192 EHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE 251
           E    + + ADLK+ +K IY AYLKNFNM K KAR IL+GKAS+  PFVIHD+ETL  AE
Sbjct: 164 EGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAE 223

Query: 252 KTLVAKLVANGI-QNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK 310
           K LV K + NG+   KE  V +F+ CQCT+VETV ELTEFAK+IP F++L LNDQVTLLK
Sbjct: 224 KGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLK 283

Query: 311 YGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL 370
           YGV+EAIFAML+S++NKDG+LVA G+GF+TREFL+SLRKPF DI+EPKF+FA+KFNALEL
Sbjct: 284 YGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALEL 343

Query: 371 DDSDISLFVAAIICCG 386
           DDSD++LF+AAII CG
Sbjct: 344 DDSDLALFIAAIILCG 359


>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
          Length = 448

 Score =  183 bits (465), Expect = 3e-46
 Identities = 120/394 (30%), Positives = 196/394 (49%), Gaps = 38/394 (9%)

Query: 71  TLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTI 130
           T     + S+ +  +VP      P   +   C +C DK+SGYHYGV ACEGCKGFFRR+I
Sbjct: 50  TAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 109

Query: 131 RLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEIL 189
           +  ++Y    D++C I K  RN+CQYCR  KC  VGMS  ++R  R     K K +    
Sbjct: 110 QKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDR----NKKKKETSKQ 165

Query: 190 TCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM 249
            C    E   TA+L  L ++I +A+ + F        +   GK + N             
Sbjct: 166 ECTESYE--MTAELDDLTEKIRKAHQETF------PSLCQLGKYTTN-----------SS 206

Query: 250 AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
           A+  +   L   G+ +K +E+         + + + ++ EFAK +PGF  L + DQ+TLL
Sbjct: 207 ADHRVRLDL---GLWDKFSEL---------ATKCIIKIVEFAKRLPGFTGLTIADQITLL 254

Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
           K    + +   + +    +   + + +G +T    +     F  + +  F FA +   LE
Sbjct: 255 KAACLDILILRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFTFANQLLPLE 313

Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
           +DD++  L  A  + CGDR  L     ++K+QE ++  L+++++   P    +FPK+L K
Sbjct: 314 MDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMK 373

Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
           + DLR +  + A+ V I  K E   ++ PL+QE+
Sbjct: 374 ITDLRSISAKGAERV-ITLKMEIPGSMPPLIQEM 406


>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  180 bits (457), Expect = 2e-45
 Identities = 118/396 (29%), Positives = 195/396 (49%), Gaps = 40/396 (10%)

Query: 71  TLSPAS--SPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRR 128
           T SPA+  + SS +  +VP      P   +   C +C DK+SGYHYGV ACEGCKGFFRR
Sbjct: 55  TPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRR 114

Query: 129 TIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAE 187
           +I+  +VY    D++C I K  RN+CQYCR  KC  VGMS  ++      R+++ K K E
Sbjct: 115 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV------RNDRNKKKKE 168

Query: 188 ILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETL 247
           +   E     + T ++  L +++ +A+ + F      A   L    +NN           
Sbjct: 169 VPKPECSESYTLTPEVGELIEKVRKAHQETF-----PALCQLGKYTTNN----------- 212

Query: 248 CMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVT 307
                        +  Q    ++ ++      S + + +  EFAK +PGF  L + DQ+T
Sbjct: 213 -------------SSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT 259

Query: 308 LLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
           LLK    + +   + +    +   + + +G +T    +     F  + +  F FA +   
Sbjct: 260 LLKAACLDILILRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFANQLLP 318

Query: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLL 427
           LE+DD++  L  A  + CGDR  L     ++ +QE ++  L+++++   P    +FPK+L
Sbjct: 319 LEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKML 378

Query: 428 QKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
            K+ DLR +  + A+ V I  K E   ++ PL+QE+
Sbjct: 379 MKITDLRSISAKGAERV-ITLKMEIPGSMPPLIQEM 413


>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  180 bits (457), Expect = 2e-45
 Identities = 118/396 (29%), Positives = 195/396 (49%), Gaps = 40/396 (10%)

Query: 71  TLSPAS--SPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRR 128
           T SPA+  + SS +  +VP      P   +   C +C DK+SGYHYGV ACEGCKGFFRR
Sbjct: 55  TPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRR 114

Query: 129 TIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAE 187
           +I+  +VY    D++C I K  RN+CQYCR  KC  VGMS  ++      R+++ K K E
Sbjct: 115 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV------RNDRNKKKKE 168

Query: 188 ILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETL 247
           +   E     + T ++  L +++ +A+ + F      A   L    +NN           
Sbjct: 169 VPKPECSESYTLTPEVGELIEKVRKAHQETF-----PALCQLGKYTTNN----------- 212

Query: 248 CMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVT 307
                        +  Q    ++ ++      S + + +  EFAK +PGF  L + DQ+T
Sbjct: 213 -------------SSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT 259

Query: 308 LLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
           LLK    + +   + +    +   + + +G +T    +     F  + +  F FA +   
Sbjct: 260 LLKAACLDILILRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFANQLLP 318

Query: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLL 427
           LE+DD++  L  A  + CGDR  L     ++ +QE ++  L+++++   P    +FPK+L
Sbjct: 319 LEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKML 378

Query: 428 QKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
            K+ DLR +  + A+ V I  K E   ++ PL+QE+
Sbjct: 379 MKITDLRSISAKGAERV-ITLKMEIPGSMPPLIQEM 413


>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
          Length = 443

 Score =  180 bits (457), Expect = 2e-45
 Identities = 118/394 (29%), Positives = 199/394 (50%), Gaps = 38/394 (9%)

Query: 71  TLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTI 130
           +L    + S+ +  +VP S    P   +   C +C DK+SGYHYGV +CEGCKGFFRR+I
Sbjct: 48  SLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSI 107

Query: 131 RLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEIL 189
           +  +VY    D++C I K  RN+CQYCR  KC  VGMS  A+R  R    +K ++K E  
Sbjct: 108 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR--NKKKKEVKEEGS 165

Query: 190 TCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM 249
              +++    +  L+ L  ++ +A+ + F        +   GK + N             
Sbjct: 166 PDSYEL----SPQLEELITKVSKAHQETF------PSLCQLGKYTTN-----------SS 204

Query: 250 AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
           A+  +   L   G+ +K +E+         + + + ++ EFAK +PGF  L + DQ+TLL
Sbjct: 205 ADHRVQLDL---GLWDKFSEL---------ATKCIIKIVEFAKRLPGFTGLSIADQITLL 252

Query: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
           K    + +   + +    +   + + +G +T    +     F  + +  F FA +   LE
Sbjct: 253 KAACLDILMLRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFAGQLLPLE 311

Query: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
           +DD++  L  A  + CGDR  L     ++K+QE ++  LRL+ +   P   ++FP++L K
Sbjct: 312 MDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMK 371

Query: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
           + DLR + T+ A+   I  K E    + PL++E+
Sbjct: 372 ITDLRGISTKGAERA-ITLKMEIPGPMPPLIREM 404


>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
          Length = 454

 Score =  179 bits (453), Expect = 6e-45
 Identities = 117/386 (30%), Positives = 196/386 (50%), Gaps = 38/386 (9%)

Query: 79  SSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD- 137
           S+ +  +VP S    P   +   C +C DK+SGYHYGV +CEGCKGFFRR+I+  +VY  
Sbjct: 67  STSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTC 126

Query: 138 KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIED 197
             D++C I K  RN+CQYCR  KC  VGMS  A+R  R    +K ++K E     +++  
Sbjct: 127 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR--NKKKKEVKEEGSPDSYEL-- 182

Query: 198 SETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAK 257
             +  L+ L  ++ +A+ + F        +   GK + N             A+  +   
Sbjct: 183 --SPQLEELITKVSKAHQETF------PSLCQLGKYTTN-----------SSADHRVQLD 223

Query: 258 LVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAI 317
           L   G+ +K +E+         + + + ++ EFAK +PGF  L + DQ+TLLK    + +
Sbjct: 224 L---GLWDKFSEL---------ATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDIL 271

Query: 318 FAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISL 377
              + +    +   + + +G +T    +     F  + +  F FA +   LE+DD++  L
Sbjct: 272 MLRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGL 330

Query: 378 FVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLV 437
             A  + CGDR  L     ++K+QE ++  LRL+ +   P   ++FP++L K+ DLR + 
Sbjct: 331 LSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGIS 390

Query: 438 TEHAQLVQIIKKTESDAALHPLLQEI 463
           T+ A+   I  K E    + PL++E+
Sbjct: 391 TKGAERA-ITLKMEIPGPMPPLIREM 415


>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
          Length = 457

 Score =  178 bits (452), Expect = 8e-45
 Identities = 114/386 (29%), Positives = 189/386 (48%), Gaps = 38/386 (9%)

Query: 79  SSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD- 137
           SS +  +VP      P   +   C +C DK+SGYHYGV ACEGCKGFFRR+I+  +VY  
Sbjct: 60  SSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTC 119

Query: 138 KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIED 197
             D++C I K  RN+CQYCR  KC  VGMS  ++      R+++ K K E+   E     
Sbjct: 120 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESV------RNDRNKKKKEVPKPECSESY 173

Query: 198 SETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAK 257
           + T ++  L +++ +A+ + F      A   L    +NN                     
Sbjct: 174 TLTPEVGELIEKVRKAHQETF-----PALCQLGKYTTNN--------------------- 207

Query: 258 LVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAI 317
              +  Q    ++ ++      S + + +  EFAK +PGF  L + DQ+TLLK    + +
Sbjct: 208 ---SSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264

Query: 318 FAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISL 377
              + +    +   + + +G +T    +     F  + +  F FA +   LE+DD++  L
Sbjct: 265 ILRICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGL 323

Query: 378 FVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLV 437
             A  + CGDR  L     ++ +QE ++  L+++++   P    +FPK+L K+ DLR + 
Sbjct: 324 LSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSIS 383

Query: 438 TEHAQLVQIIKKTESDAALHPLLQEI 463
            + A+ V I  K E   ++ PL+QE+
Sbjct: 384 AKGAERV-ITLKMEIPGSMPPLIQEM 408


>gi|194294519 nuclear receptor subfamily 1, group H, member 3
           isoform c [Homo sapiens]
          Length = 402

 Score =  156 bits (395), Expect = 3e-38
 Identities = 121/428 (28%), Positives = 190/428 (44%), Gaps = 66/428 (15%)

Query: 62  GSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGAL--NIECRICGDKASGYHYGVHAC 119
           G + +  T  L+ A  PS  T  + P    + P+  +  N  C +CGDKASG+HY V +C
Sbjct: 12  GLEAAEPTALLTRAEPPSEPT-EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSC 70

Query: 120 EGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
           EGCKGFFRR++ +K  +  C     C +    R KCQ CR  KC   GM    +      
Sbjct: 71  EGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 129

Query: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNP 237
           R +K K + E           E A   SL  R                        +++P
Sbjct: 130 RLKKLKRQEE-----------EQAHATSLPPR------------------------ASSP 154

Query: 238 PFVIHDM--ETLCMAEKTLVAKLVAN-----------------GIQNKEAEVRIFHCCQC 278
           P ++  +  E L M EK + A+   N                    ++EA  + F     
Sbjct: 155 PQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTE 214

Query: 279 TSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF 338
            ++ +V E+ +FAK +PGF  L   DQ+ LLK    E +    S   N     + +   F
Sbjct: 215 LAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDF 274

Query: 339 I--TREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH 396
                +F K+  +   + + P F+F+   N L+L+D++ +L +A  I   DRP + +   
Sbjct: 275 SYNREDFAKAGLQ--VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQ 332

Query: 397 IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL 456
           +E++Q   V  L  ++  +HP D  +FP++L K+  LR L + H++  Q+      D  L
Sbjct: 333 VERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSE--QVFALRLQDKKL 390

Query: 457 HPLLQEIY 464
            PLL EI+
Sbjct: 391 PPLLSEIW 398


>gi|194294517 nuclear receptor subfamily 1, group H, member 3
           isoform a [Homo sapiens]
          Length = 447

 Score =  156 bits (395), Expect = 3e-38
 Identities = 121/428 (28%), Positives = 190/428 (44%), Gaps = 66/428 (15%)

Query: 62  GSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGAL--NIECRICGDKASGYHYGVHAC 119
           G + +  T  L+ A  PS  T  + P    + P+  +  N  C +CGDKASG+HY V +C
Sbjct: 57  GLEAAEPTALLTRAEPPSEPT-EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSC 115

Query: 120 EGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
           EGCKGFFRR++ +K  +  C     C +    R KCQ CR  KC   GM    +      
Sbjct: 116 EGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 174

Query: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNP 237
           R +K K + E           E A   SL  R                        +++P
Sbjct: 175 RLKKLKRQEE-----------EQAHATSLPPR------------------------ASSP 199

Query: 238 PFVIHDM--ETLCMAEKTLVAKLVAN-----------------GIQNKEAEVRIFHCCQC 278
           P ++  +  E L M EK + A+   N                    ++EA  + F     
Sbjct: 200 PQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTE 259

Query: 279 TSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF 338
            ++ +V E+ +FAK +PGF  L   DQ+ LLK    E +    S   N     + +   F
Sbjct: 260 LAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDF 319

Query: 339 I--TREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH 396
                +F K+  +   + + P F+F+   N L+L+D++ +L +A  I   DRP + +   
Sbjct: 320 SYNREDFAKAGLQ--VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQ 377

Query: 397 IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL 456
           +E++Q   V  L  ++  +HP D  +FP++L K+  LR L + H++  Q+      D  L
Sbjct: 378 VERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSE--QVFALRLQDKKL 435

Query: 457 HPLLQEIY 464
            PLL EI+
Sbjct: 436 PPLLSEIW 443


>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
          Length = 463

 Score =  154 bits (389), Expect = 2e-37
 Identities = 127/448 (28%), Positives = 199/448 (44%), Gaps = 67/448 (14%)

Query: 28  LQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVP 87
           L  +G+   +  S     SG+        L + P S  +V+    S +SS      P +P
Sbjct: 63  LNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVN---SVSSSEDIKPLPGLP 119

Query: 88  GSVD-----ESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDR 141
           G  +      SP   +   C ICGD++SG HYGV++CEGCKGFF+RTIR  L+Y  + ++
Sbjct: 120 GIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNK 179

Query: 142 SCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETA 201
            C I K+ RN+CQYCR+ KCL +GM   A++  R    E+A+ +AE  T  H  ED    
Sbjct: 180 DCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGH--EDM--- 234

Query: 202 DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVAN 261
                                                     +E +  AE  +  K  + 
Sbjct: 235 -----------------------------------------PVERILEAELAVEPKTESY 253

Query: 262 GIQNKEAEVR--IFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA 319
           G  N E      + + C     +  T L E+AK IP F++L L DQV LL+ G  E + A
Sbjct: 254 GDMNMENSTNDPVTNICHAADKQLFT-LVEWAKRIPHFSDLTLEDQVILLRAGWNELLIA 312

Query: 320 MLS--SVMNKDGMLVAYG-NGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDIS 376
             S  SV  +DG+L+A G +   +      +   F  ++    +   K   +++D S++ 
Sbjct: 313 SFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLT---ELVSKMKDMQMDKSELG 369

Query: 377 LFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQL 436
              A ++   D  GL N   +E ++E +   L  + +  +P+    F KLL ++  LR +
Sbjct: 370 CLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSI 429

Query: 437 ---VTEHAQLVQIIKKTESDAALHPLLQ 461
                EH    ++I  T  D  L  +L+
Sbjct: 430 GLKCLEHLFFFKLIGDTPIDTFLMEMLE 457


>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
          Length = 462

 Score =  151 bits (382), Expect = 1e-36
 Identities = 115/411 (27%), Positives = 193/411 (46%), Gaps = 65/411 (15%)

Query: 68  ITDTLSPASSPSSVTYPV-------VPGSVDESPSGALNIECRICGDKASGYHYGVHACE 120
           ++  ++P SS   +  P+       VP     + +      C ICGD++SG HYGV++CE
Sbjct: 94  LSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCE 153

Query: 121 GCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRS 179
           GCKGFF+RT+R  L Y  + ++ C I K+ RN+CQYCR+ KCL++GM   A++  R    
Sbjct: 154 GCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGK 213

Query: 180 EKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYL--KNFNMNKVKARVILSGKASNNP 237
           ++          E+++E + +A+     +RI EA L  +      V+A + L+  + N+P
Sbjct: 214 DRN---------ENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDP 264

Query: 238 PFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGF 297
                                             + + CQ    +  T L E+AK IP F
Sbjct: 265 ----------------------------------VTNICQAADKQLFT-LVEWAKRIPHF 289

Query: 298 ANLDLNDQVTLLKYGVYEAIFAMLS--SVMNKDGMLVAYGNGFITREFLKS--LRKPFCD 353
           + L L+DQV LL+ G  E + A  S  S+  KDG+L+A G   + R    S  +   F  
Sbjct: 290 SELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGL-HVHRNSAHSAGVGAIFDR 348

Query: 354 IMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQ 413
           ++    +   K   +++D +++    A ++   D  GL N   +E ++E +   L  + +
Sbjct: 349 VLT---ELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCK 405

Query: 414 SNHPDDIFLFPKLLQKMADLRQL---VTEHAQLVQIIKKTESDAALHPLLQ 461
             +P+    F KLL ++  LR +     EH    ++I  T  D  L  +L+
Sbjct: 406 HKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 456


>gi|11415052 retinoid X receptor, beta [Homo sapiens]
          Length = 533

 Score =  143 bits (361), Expect = 3e-34
 Identities = 120/415 (28%), Positives = 183/415 (44%), Gaps = 66/415 (15%)

Query: 59  SCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHA 118
           S PG       D   P      +  P  PG       GA    C ICGD++SG HYGV++
Sbjct: 167 SLPGGGSGPPEDVKPPVLGVRGLHCPPPPGG-----PGAGKRLCAICGDRSSGKHYGVYS 221

Query: 119 CEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
           CEGCKGFF+RTIR  L Y  + ++ C + K+ RN+CQYCR+ KCL+ GM   A++  R  
Sbjct: 222 CEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQR 281

Query: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYL----KNFNMNKVKARVILSGKA 233
             +K          + D E +  A  +    RI EA L    K+    +       SG +
Sbjct: 282 GKDK----------DGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSS 331

Query: 234 SNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKA 293
            N+P                                  + + CQ    +  T L E+AK 
Sbjct: 332 PNDP----------------------------------VTNICQAADKQLFT-LVEWAKR 356

Query: 294 IPGFANLDLNDQVTLLKYGVYEAIFAMLS--SVMNKDGMLVAYGNGFITREFLKS--LRK 349
           IP F++L L+DQV LL+ G  E + A  S  S+  +DG+L+A G   + R    S  +  
Sbjct: 357 IPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGL-HVHRNSAHSAGVGA 415

Query: 350 PFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLR 409
            F  ++    +   K   + +D +++    A I+   D  GL N   +E ++E +   L 
Sbjct: 416 IFDRVLT---ELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLE 472

Query: 410 LHLQSNHPDDIFLFPKLLQKMADLRQL---VTEHAQLVQIIKKTESDAALHPLLQ 461
            + +  +P+    F KLL ++  LR +     EH    ++I  T  D  L  +L+
Sbjct: 473 TYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527


>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
           a [Homo sapiens]
          Length = 414

 Score =  137 bits (345), Expect = 2e-32
 Identities = 113/405 (27%), Positives = 179/405 (44%), Gaps = 70/405 (17%)

Query: 74  PASSPSSVTY-----PVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRR 128
           PAS+P+         P  PGS  +      +IEC +CGDK+SG HYG   CEGCK FF+R
Sbjct: 48  PASTPAQTAAGGQGGPGGPGS--DKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKR 105

Query: 129 TIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEK-----A 182
           ++R  L Y  + +R+C I + +RN+CQYCR  KCL VGM   A++ GRMP ++      A
Sbjct: 106 SVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFA 165

Query: 183 KLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIH 242
               + L C                     +YL  +    ++A            P+   
Sbjct: 166 LTNGDPLNC--------------------HSYLSGYISLLLRAE-----------PYPTS 194

Query: 243 DMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDL 302
              + CM    ++      GI+N          C+  +   +    E+A+ IP F +L +
Sbjct: 195 RFGSQCMQPNNIM------GIEN---------ICE-LAARMLFSAVEWARNIPFFPDLQI 238

Query: 303 NDQVTLLKYGVYEAIF----AMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPK 358
            DQV LL+   +  +F    A  S  ++   +L A   G             F D +   
Sbjct: 239 TDQVALLRL-TWSELFVLNAAQCSMPLHVAPLLAA--AGLHASPMSADRVVAFMDHIRIF 295

Query: 359 FDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPD 418
            +   K  AL +D ++ S   A ++   D  GL +V H+E +QE     L  +++S +P+
Sbjct: 296 QEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPN 355

Query: 419 DIFLFPKLLQKMADLRQL---VTEHAQLVQIIKKTESDAALHPLL 460
               F KLL ++  LR +   V E    V+++ KT  +  +  +L
Sbjct: 356 QPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 400


>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
           sapiens]
          Length = 614

 Score =  137 bits (344), Expect = 3e-32
 Identities = 72/155 (46%), Positives = 98/155 (63%), Gaps = 21/155 (13%)

Query: 38  SQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDT--LSPASSPSSVTYPVVPGSVDESPS 95
           S S    SS SF      Y GS PGS    + D+  +SP+ S S++T             
Sbjct: 83  SSSSSSSSSSSF------YNGSPPGSLQVAMEDSSRVSPSKSTSNIT-----------KL 125

Query: 96  GALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKC 153
             + + C++CGD ASG+HYGVHACEGCKGFFRR+I+  + Y +C  + +C I + NRN+C
Sbjct: 126 NGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRC 185

Query: 154 QYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEI 188
           Q CRF KCLSVGMS +A+RFGR+P+ EK ++ AE+
Sbjct: 186 QQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEM 220



 Score =  100 bits (248), Expect = 4e-21
 Identities = 57/160 (35%), Positives = 90/160 (56%), Gaps = 3/160 (1%)

Query: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMN-KDGMLVAYGNGFITRE 342
           V E+ EFAK IPGF +L  +DQVTLLK G +E +    +S+ N KD  ++       + +
Sbjct: 447 VREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQ 506

Query: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
            L ++     D++   FDF+ K N+L L + ++ LF A ++   DR G+ N   +E++QE
Sbjct: 507 ELGAMGMG--DLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQE 564

Query: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
            ++  LR  +  N P +   F KLL K+ DLR L   H++
Sbjct: 565 TLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSE 604


>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
           sapiens]
          Length = 423

 Score =  137 bits (344), Expect = 3e-32
 Identities = 112/411 (27%), Positives = 177/411 (43%), Gaps = 63/411 (15%)

Query: 65  GSVITDTLSPASSPSSVTYPVVPGSVDESPSGA----LNIECRICGDKASGYHYGVHACE 120
           GS    T      P +   P   G   + P G+     +IEC +CGDK+SG HYG   CE
Sbjct: 45  GSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCE 104

Query: 121 GCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRS 179
           GCK FF+R++R  L Y  + +R+C I + +RN+CQYCR  KCL VGM   A++ GRMP +
Sbjct: 105 GCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPT 164

Query: 180 EKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKAS---NN 236
           +    +  +                              N + +     LSG  S     
Sbjct: 165 QPNPGQYALT-----------------------------NGDPLNGHCYLSGYISLLLRA 195

Query: 237 PPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPG 296
            P+      + CM    ++      GI+N          C+  +   +    E+A+ IP 
Sbjct: 196 EPYPTSRYGSQCMQPNNIM------GIEN---------ICE-LAARLLFSAVEWARNIPF 239

Query: 297 FANLDLNDQVTLLKYGVYEAIF----AMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFC 352
           F +L + DQV+LL+   +  +F    A  S  ++   +L A   G             F 
Sbjct: 240 FPDLQITDQVSLLRL-TWSELFVLNAAQCSMPLHVAPLLAA--AGLHASPMSADRVVAFM 296

Query: 353 DIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHL 412
           D +    +   K  AL +D ++ S   A ++   D  GL +  HIE +QE     L  ++
Sbjct: 297 DHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYV 356

Query: 413 QSNHPDDIFLFPKLLQKMADLRQL---VTEHAQLVQIIKKTESDAALHPLL 460
           +S +P+    F KLL ++  LR +   V E    V+++ KT  +  +  +L
Sbjct: 357 RSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407


>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  136 bits (343), Expect = 4e-32
 Identities = 106/400 (26%), Positives = 178/400 (44%), Gaps = 38/400 (9%)

Query: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHK 160
           C +CGD+A+G+H+    CEGCKGFFRR+++ K ++    +  C+I K NR  CQ CR  +
Sbjct: 24  CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKR 83

Query: 161 CLSVGMSHNAI---------RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIY 211
           C+ +GM    I         R   + R E+  LK  +     + +    A L     + Y
Sbjct: 84  CVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTY 143

Query: 212 EAYLKNFNMNKVKARVILSGKA------SNNPPFVIHDMETLC---------MAEKTLVA 256
           +    +F   +   RV   G +      S + P    D  + C         M + +  +
Sbjct: 144 DPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFS 203

Query: 257 KLVANGIQNKEAEVRIF--------HCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL 308
            L  +   + +  V +         H     S  ++ ++  FAK IPGF +L   DQ+ L
Sbjct: 204 NLDLSEEDSDDPSVTLELSQLSMLPHLADLVSY-SIQKVIGFAKMIPGFRDLTSEDQIVL 262

Query: 309 LKYGVYEAIFAMLSSVMNKDGMLVAYGN-GFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
           LK    E I    +     D M    GN  +  R    +      +++EP   F +    
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322

Query: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNH--PDDIFLFPK 425
           L L + +  L +A  I   DRPG+ +   IE +Q+ + + L+ +++  H  P    L+ K
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382

Query: 426 LLQKMADLRQLVTEHAQLVQIIK-KTESDAALHPLLQEIY 464
           ++QK+ADLR L  EH++  + +  + E    L PL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422


>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  136 bits (343), Expect = 4e-32
 Identities = 106/400 (26%), Positives = 178/400 (44%), Gaps = 38/400 (9%)

Query: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHK 160
           C +CGD+A+G+H+    CEGCKGFFRR+++ K ++    +  C+I K NR  CQ CR  +
Sbjct: 24  CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKR 83

Query: 161 CLSVGMSHNAI---------RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIY 211
           C+ +GM    I         R   + R E+  LK  +     + +    A L     + Y
Sbjct: 84  CVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTY 143

Query: 212 EAYLKNFNMNKVKARVILSGKA------SNNPPFVIHDMETLC---------MAEKTLVA 256
           +    +F   +   RV   G +      S + P    D  + C         M + +  +
Sbjct: 144 DPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFS 203

Query: 257 KLVANGIQNKEAEVRIF--------HCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL 308
            L  +   + +  V +         H     S  ++ ++  FAK IPGF +L   DQ+ L
Sbjct: 204 NLDLSEEDSDDPSVTLELSQLSMLPHLADLVSY-SIQKVIGFAKMIPGFRDLTSEDQIVL 262

Query: 309 LKYGVYEAIFAMLSSVMNKDGMLVAYGN-GFITREFLKSLRKPFCDIMEPKFDFAMKFNA 367
           LK    E I    +     D M    GN  +  R    +      +++EP   F +    
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322

Query: 368 LELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNH--PDDIFLFPK 425
           L L + +  L +A  I   DRPG+ +   IE +Q+ + + L+ +++  H  P    L+ K
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382

Query: 426 LLQKMADLRQLVTEHAQLVQIIK-KTESDAALHPLLQEIY 464
           ++QK+ADLR L  EH++  + +  + E    L PL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422


>gi|224177493 nuclear receptor subfamily 1, group D, member 2
           isoform 2 [Homo sapiens]
          Length = 504

 Score =  129 bits (324), Expect = 6e-30
 Identities = 55/100 (55%), Positives = 76/100 (76%), Gaps = 2/100 (2%)

Query: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFH 159
           C++CGD ASG+HYGVHACEGCKGFFRR+I+  + Y KC  + +C I + NRN+CQ CRF 
Sbjct: 28  CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 87

Query: 160 KCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
           KCLSVGMS +A+RFGR+P+ EK ++  E+ +    + +S+
Sbjct: 88  KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 127



 Score =  111 bits (277), Expect = 2e-24
 Identities = 60/160 (37%), Positives = 94/160 (58%), Gaps = 3/160 (1%)

Query: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF-ITRE 342
           V E+ EFAK IPGF +L  +DQV LLK G +E +    +S+ +     V + +G   + +
Sbjct: 338 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 397

Query: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
            L S+     D++   F+F+ K NAL+L D ++SLF A ++   DR G+ NV  +E +QE
Sbjct: 398 DLHSMGAG--DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 455

Query: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
            ++  LR  +  NHP++  +F KLL K+ DLR L   H++
Sbjct: 456 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSE 495


>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
          Length = 336

 Score =  129 bits (324), Expect = 6e-30
 Identities = 91/324 (28%), Positives = 156/324 (48%), Gaps = 37/324 (11%)

Query: 140 DRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
           D++C I K  RN+CQYCR  KC  VGMS  ++R  R     K K +     C    E   
Sbjct: 8   DKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDR----NKKKKETSKQECTESYE--M 61

Query: 200 TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLV 259
           TA+L  L ++I +A+ + F        +   GK + N             A+  +   L 
Sbjct: 62  TAELDDLTEKIRKAHQETF------PSLCQLGKYTTNSS-----------ADHRVRLDL- 103

Query: 260 ANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFA 319
             G+ +K +E+         + + + ++ EFAK +PGF  L + DQ+TLLK    + +  
Sbjct: 104 --GLWDKFSEL---------ATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILIL 152

Query: 320 MLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFV 379
            + +    +   + + +G +T    +     F  + +  F FA +   LE+DD++  L  
Sbjct: 153 RICTRYTPEQDTMTFSDG-LTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLS 211

Query: 380 AAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTE 439
           A  + CGDR  L     ++K+QE ++  L+++++   P    +FPK+L K+ DLR +  +
Sbjct: 212 AICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAK 271

Query: 440 HAQLVQIIKKTESDAALHPLLQEI 463
            A+ V I  K E   ++ PL+QE+
Sbjct: 272 GAERV-ITLKMEIPGSMPPLIQEM 294


>gi|224177491 nuclear receptor subfamily 1, group D, member 2
           isoform 1 [Homo sapiens]
          Length = 579

 Score =  129 bits (324), Expect = 6e-30
 Identities = 55/100 (55%), Positives = 76/100 (76%), Gaps = 2/100 (2%)

Query: 102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFH 159
           C++CGD ASG+HYGVHACEGCKGFFRR+I+  + Y KC  + +C I + NRN+CQ CRF 
Sbjct: 103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFK 162

Query: 160 KCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSE 199
           KCLSVGMS +A+RFGR+P+ EK ++  E+ +    + +S+
Sbjct: 163 KCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNSQ 202



 Score =  111 bits (277), Expect = 2e-24
 Identities = 60/160 (37%), Positives = 94/160 (58%), Gaps = 3/160 (1%)

Query: 284 VTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF-ITRE 342
           V E+ EFAK IPGF +L  +DQV LLK G +E +    +S+ +     V + +G   + +
Sbjct: 413 VKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVD 472

Query: 343 FLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQE 402
            L S+     D++   F+F+ K NAL+L D ++SLF A ++   DR G+ NV  +E +QE
Sbjct: 473 DLHSMGAG--DLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQE 530

Query: 403 GIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQ 442
            ++  LR  +  NHP++  +F KLL K+ DLR L   H++
Sbjct: 531 TLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSE 570


>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
           sapiens]
          Length = 395

 Score =  125 bits (313), Expect = 1e-28
 Identities = 109/391 (27%), Positives = 171/391 (43%), Gaps = 64/391 (16%)

Query: 86  VPGSVDESPSGALNIE----------CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLV 135
           V  S D SPS   N+           C ICGD+A+G HYG  +C+GCKGFFRR++R   +
Sbjct: 12  VESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHM 71

Query: 136 YD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHD 194
           Y  +  R C + K  RN+C+YCR  KC   GM   A++  R            I T    
Sbjct: 72  YSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNER----------DRISTRRSS 121

Query: 195 IEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTL 254
            EDS    + +L +             +V +R I S  +  N                 +
Sbjct: 122 YEDSSLPSINALLQA------------EVLSRQITSPVSGIN---------------GDI 154

Query: 255 VAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLK--YG 312
            AK +A+          I   C+ +  E +  L E+AK IP F  L L+DQV LL+   G
Sbjct: 155 RAKKIAS----------IADVCE-SMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAG 203

Query: 313 VYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDD 372
            +  + A   S++ KD +L+  GN +I       L +     +    +  + F  L++DD
Sbjct: 204 EHLLLGATKRSMVFKDVLLL--GNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDD 261

Query: 373 SDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMAD 432
           ++ +   A I    D  GL + G I++++  +   L  ++     D    F +LL  +  
Sbjct: 262 NEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPT 321

Query: 433 LRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
           L+ +  +  + +Q I K    A +  LLQE+
Sbjct: 322 LQSITWQMIEQIQFI-KLFGMAKIDNLLQEM 351


>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
           sapiens]
          Length = 458

 Score =  120 bits (300), Expect = 3e-27
 Identities = 121/478 (25%), Positives = 196/478 (41%), Gaps = 61/478 (12%)

Query: 5   ESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSD 64
           E  LC +S  +   ++S  S     E  +   ++ S+   S G        Y  +  G  
Sbjct: 18  EELLCRMSNKDR-HIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQ 76

Query: 65  GSVITDTLSPA------SSPSSVTYPVVPGSVDESPSGALNIE--------CRICGDKAS 110
             + +  L P+      S P    Y     ++ E P               C +CGD AS
Sbjct: 77  NGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIAS 136

Query: 111 GYHYGVHACEGCKGFFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHN 169
           GYHYGV +CE CK FF+RTI+  + Y       C+I K+ R  CQ CRF KCL VGM   
Sbjct: 137 GYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKE 196

Query: 170 AIRFGRMPRSEKAKLKAEILTCEHDIEDSE--TADLKSLAKRIYEAYLKNFNMNKVKARV 227
            +R  R+ R  + K K  I     D E+S      L   AK+ Y         NK+ + +
Sbjct: 197 GVRLDRV-RGGRQKYKRRI-----DAENSPYLNPQLVQPAKKPY---------NKIVSHL 241

Query: 228 ILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTEL 287
           +++       P  I+ M    + +  + A      + ++E  V I               
Sbjct: 242 LVA------EPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVII--------------- 280

Query: 288 TEFAKAIPGFANLDLNDQVTLLKYGVYEAIF--AMLSSVMNKDGMLVAYGNGFITREFLK 345
             +AK IPGF+ L L DQ++LL+    E +    +  S+  +D ++  Y + +I  E   
Sbjct: 281 -GWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELV--YADDYIMDEDQS 337

Query: 346 SLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIV 405
            L     D+         K+ +++L+  +     A  +   D   + +V  ++K+Q+ + 
Sbjct: 338 KLAG-LLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLH 396

Query: 406 HVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
             L+ +    H +D     K+L  +  LRQ  T+  Q    I K E    +H L  E+
Sbjct: 397 EALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNI-KLEGKVPMHKLFLEM 453


>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
           sapiens]
          Length = 435

 Score =  119 bits (297), Expect = 8e-27
 Identities = 117/464 (25%), Positives = 190/464 (40%), Gaps = 60/464 (12%)

Query: 19  LESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPA--- 75
           ++S  S     E  +   ++ S+   S G        Y  +  G    + +  L P+   
Sbjct: 8   IDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPI 67

Query: 76  ---SSPSSVTYPVVPGSVDESPSGALNIE--------CRICGDKASGYHYGVHACEGCKG 124
              S P    Y     ++ E P               C +CGD ASGYHYGV +CE CK 
Sbjct: 68  LGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKA 127

Query: 125 FFRRTIRLKLVYD-KCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAK 183
           FF+RTI+  + Y       C+I K+ R  CQ CRF KCL VGM    +R  R+ R  + K
Sbjct: 128 FFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRV-RGGRQK 186

Query: 184 LKAEILTCEHDIEDSE--TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVI 241
            K  I     D E+S      L   AK+ Y         NK+ + ++++       P  I
Sbjct: 187 YKRRI-----DAENSPYLNPQLVQPAKKPY---------NKIVSHLLVA------EPEKI 226

Query: 242 HDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD 301
           + M    + +  + A      + ++E  V I                 +AK IPGF+ L 
Sbjct: 227 YAMPDPTVPDSDIKALTTLCDLADRELVVII----------------GWAKHIPGFSTLS 270

Query: 302 LNDQVTLLKYGVYEAIF--AMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKF 359
           L DQ++LL+    E +    +  S+  +D ++  Y + +I  E    L     D+     
Sbjct: 271 LADQMSLLQSAWMEILILGVVYRSLSFEDELV--YADDYIMDEDQSKLAG-LLDLNNAIL 327

Query: 360 DFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDD 419
               K+ +++L+  +     A  +   D   + +V  ++K+Q+ +   L+ +    H +D
Sbjct: 328 QLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMED 387

Query: 420 IFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI 463
                K+L  +  LRQ  T+  Q    I K E    +H L  E+
Sbjct: 388 PRRAGKMLMTLPLLRQTSTKAVQHFYNI-KLEGKVPMHKLFLEM 430


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,420,130
Number of Sequences: 37866
Number of extensions: 776248
Number of successful extensions: 2696
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2297
Number of HSP's gapped (non-prelim): 224
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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