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Search of human proteins with 5032193
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]
(416 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5032193 TNF receptor-associated factor 1 [Homo sapiens] 845 0.0
gi|22027612 TNF receptor-associated factor 2 [Homo sapiens] 275 7e-74
gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo sap... 231 9e-61
gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo sap... 231 9e-61
gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo sap... 212 6e-55
gi|22027627 TNF receptor-associated factor 5 [Homo sapiens] 211 1e-54
gi|77404348 TNF receptor-associated factor 5 [Homo sapiens] 211 1e-54
gi|11321603 TNF receptor-associated factor 5 [Homo sapiens] 211 1e-54
gi|22027622 TNF receptor-associated factor 4 [Homo sapiens] 128 1e-29
gi|22027630 TNF receptor-associated factor 6 [Homo sapiens] 105 1e-22
gi|4759254 TNF receptor-associated factor 6 [Homo sapiens] 105 1e-22
gi|153070262 meprin A alpha [Homo sapiens] 39 0.011
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 37 0.025
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 37 0.043
gi|21735548 centrosomal protein 2 [Homo sapiens] 36 0.056
gi|156104908 myosin heavy chain 6 [Homo sapiens] 36 0.056
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 36 0.074
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 36 0.074
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 36 0.074
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 35 0.096
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 35 0.096
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 35 0.096
gi|194294510 kinesin family member C3 isoform 2 [Homo sapiens] 35 0.096
gi|194294508 kinesin family member C3 isoform 3 [Homo sapiens] 35 0.096
gi|94536858 kinesin family member C3 isoform 1 [Homo sapiens] 35 0.096
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 35 0.096
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi... 35 0.096
gi|51317366 myosin XVIIIB [Homo sapiens] 35 0.13
gi|221139761 zinc finger protein 853 [Homo sapiens] 35 0.16
gi|5453726 leucine rich repeat (in FLII) interacting protein 2 i... 35 0.16
>gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]
Length = 416
Score = 845 bits (2183), Expect = 0.0
Identities = 416/416 (100%), Positives = 416/416 (100%)
Query: 1 MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALCCAGCLSENPRNGEDQICPKCRGE 60
MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALCCAGCLSENPRNGEDQICPKCRGE
Sbjct: 1 MASSSGSSPRPAPDENEFPFGCPPTVCQDPKEPRALCCAGCLSENPRNGEDQICPKCRGE 60
Query: 61 DLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLL 120
DLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLL
Sbjct: 61 DLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLL 120
Query: 121 GFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQH 180
GFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQH
Sbjct: 121 GFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQH 180
Query: 181 FMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQ 240
FMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQ
Sbjct: 181 FMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQ 240
Query: 241 QTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAK 300
QTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAK
Sbjct: 241 QTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAK 300
Query: 301 YGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAID 360
YGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAID
Sbjct: 301 YGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAID 360
Query: 361 AFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETST 416
AFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETST
Sbjct: 361 AFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETST 416
>gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]
Length = 501
Score = 275 bits (702), Expect = 7e-74
Identities = 158/388 (40%), Positives = 221/388 (56%), Gaps = 57/388 (14%)
Query: 34 RALCCAGCLSENPRNGED-----QICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAG--- 85
R+L C C + P G D ++CPK L G + +EK V G
Sbjct: 159 RSLSCRHCRA--PCCGADVKAHHEVCPKF---PLTCDGCGKKKIPREKFQDHVKTCGKCR 213
Query: 86 IGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNL 145
+ C F +GC + QEHEV HL +LL + + K LG +G L++
Sbjct: 214 VPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCE 273
Query: 146 SDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLN 205
S LE K FENIV VLN
Sbjct: 274 S-------------------------------------------LEKKTATFENIVCVLN 290
Query: 206 KEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASF 265
+EVE + Q +LD+++I +L +V +L++++ KD A+ LEQ + ME +++
Sbjct: 291 REVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTY 350
Query: 266 DGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLF 325
DG F+WKI++ R+ E+ GR ++FSPAFYT++YGYK+CLR+YLNGDGTG+ THLSLF
Sbjct: 351 DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLF 410
Query: 326 IVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCP 385
V+M+G DALL WPF KVT MLLDQNNREH IDAFRPD++S+SFQRP ++ N+ASGCP
Sbjct: 411 FVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCP 470
Query: 386 LFFPLSKLQSPKHAYVKDDTMFLKCIVE 413
LF P+SK+++ K++YV+DD +F+K IV+
Sbjct: 471 LFCPVSKMEA-KNSYVRDDAIFIKAIVD 497
>gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 231 bits (589), Expect = 9e-61
Identities = 150/414 (36%), Positives = 219/414 (52%), Gaps = 55/414 (13%)
Query: 34 RALCCAGCLSENP----RNGEDQICPKCRGEDLQSISPGSRLRTQEKAH-PEVAEAGIGC 88
R C+ C S+ P + ED CP S + LR++ AH E A C
Sbjct: 173 REATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTC 232
Query: 89 PFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLS-- 146
F GC F+G+ Q ++ HE +S H+NLL K+W L ++L QN S
Sbjct: 233 SFKRYGCVFQGTNQQIKAHEASSAVQHVNLL----KEWSNSL-----EKKVSLLQNESVE 283
Query: 147 -DLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK-----EKLLAELEGKLRVFE-- 198
+ +Q+ E++ R E + H + + L EL+ ++R F
Sbjct: 284 KNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQN 343
Query: 199 ---------NIVAVLNKEVE-------ASHLALATSIHQSQLDRERILSLEQRVVELQQT 242
++ ++ N+ E A +A T + +SQL R Q
Sbjct: 344 WEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRH------------DQM 391
Query: 243 LAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYG 302
L+ D L ++ +++E AS++G +WKI + RR E+ G+T+SL+S FYT +G
Sbjct: 392 LSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFG 451
Query: 303 YKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQ-NNREHAIDA 361
YK+C R+YLNGDG GK THLSLF VIMRGEYDALLPWPF+ KVT ML+DQ ++R H DA
Sbjct: 452 YKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDA 511
Query: 362 FRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETS 415
F+PD +S+SF++P E N+ASGCP+F + L++ Y+KDDT+F+K IV+TS
Sbjct: 512 FKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIFIKVIVDTS 563
>gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 231 bits (589), Expect = 9e-61
Identities = 150/414 (36%), Positives = 219/414 (52%), Gaps = 55/414 (13%)
Query: 34 RALCCAGCLSENP----RNGEDQICPKCRGEDLQSISPGSRLRTQEKAH-PEVAEAGIGC 88
R C+ C S+ P + ED CP S + LR++ AH E A C
Sbjct: 173 REATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTC 232
Query: 89 PFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLS-- 146
F GC F+G+ Q ++ HE +S H+NLL K+W L ++L QN S
Sbjct: 233 SFKRYGCVFQGTNQQIKAHEASSAVQHVNLL----KEWSNSL-----EKKVSLLQNESVE 283
Query: 147 -DLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK-----EKLLAELEGKLRVFE-- 198
+ +Q+ E++ R E + H + + L EL+ ++R F
Sbjct: 284 KNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQN 343
Query: 199 ---------NIVAVLNKEVE-------ASHLALATSIHQSQLDRERILSLEQRVVELQQT 242
++ ++ N+ E A +A T + +SQL R Q
Sbjct: 344 WEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRH------------DQM 391
Query: 243 LAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYG 302
L+ D L ++ +++E AS++G +WKI + RR E+ G+T+SL+S FYT +G
Sbjct: 392 LSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFG 451
Query: 303 YKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQ-NNREHAIDA 361
YK+C R+YLNGDG GK THLSLF VIMRGEYDALLPWPF+ KVT ML+DQ ++R H DA
Sbjct: 452 YKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDA 511
Query: 362 FRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVETS 415
F+PD +S+SF++P E N+ASGCP+F + L++ Y+KDDT+F+K IV+TS
Sbjct: 512 FKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIFIKVIVDTS 563
>gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo
sapiens]
Length = 543
Score = 212 bits (539), Expect = 6e-55
Identities = 134/365 (36%), Positives = 196/365 (53%), Gaps = 60/365 (16%)
Query: 88 CPFAGVGCSFK----------GSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESG 137
CP V C K G+ Q ++ HE +S H+NLL K+W L
Sbjct: 197 CPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLL----KEWSNSL-----EK 247
Query: 138 PMALEQNLS---DLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK-----EKLLAE 189
++L QN S + +Q+ E++ R E + H + + L E
Sbjct: 248 KVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKE 307
Query: 190 LEGKLRVFE-----------NIVAVLNKEVE-------ASHLALATSIHQSQLDRERILS 231
L+ ++R F ++ ++ N+ E A +A T + +SQL R
Sbjct: 308 LDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRH---- 363
Query: 232 LEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSL 291
Q L+ D L ++ +++E AS++G +WKI + RR E+ G+T+SL
Sbjct: 364 --------DQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSL 415
Query: 292 FSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLD 351
+S FYT +GYK+C R+YLNGDG GK THLSLF VIMRGEYDALLPWPF+ KVT ML+D
Sbjct: 416 YSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMD 475
Query: 352 Q-NNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKC 410
Q ++R H DAF+PD +S+SF++P E N+ASGCP+F + L++ Y+KDDT+F+K
Sbjct: 476 QGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLEN--GTYIKDDTIFIKV 533
Query: 411 IVETS 415
IV+TS
Sbjct: 534 IVDTS 538
>gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 211 bits (536), Expect = 1e-54
Identities = 143/429 (33%), Positives = 223/429 (51%), Gaps = 81/429 (18%)
Query: 27 CQDPKEPRALCCAGCLSENPRNGEDQICPK----CRGEDLQSISPGSRLRTQEKAHPEVA 82
CQ KE C + N +N E+ +CP+ C + I L+T+ H V
Sbjct: 161 CQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKII-----LKTEVDEHLAVC 215
Query: 83 -EAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMAL 141
EA CPF GC+ +++Q+HE ++ H+ L+L Q L
Sbjct: 216 PEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQ---------------L 260
Query: 142 EQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK--EKLLAELEGKLRVF-E 198
E+ +SDL S Q+E +Q + +KL E + ++F +
Sbjct: 261 EEQISDLHK-------------------SLEQKESKIQQLAETIKKLEKEFKQFAQLFGK 301
Query: 199 NIVAVLNKEVEASHLA----LATSIHQ---------SQLD-----------RERILSLE- 233
N + N +V ASH+ L +HQ ++ D +++I LE
Sbjct: 302 NGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLEN 361
Query: 234 --QRVVELQQTLAQKDQ-------ALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESA 284
QR+ L++ + D L K E+ +L+E ++G +WK+T+ + E+
Sbjct: 362 NDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAV 421
Query: 285 CGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNK 344
G TVS+FS +FYT++ GY+LC R YLNGDG+G+ +HLSL+ V+MRGE+D+LL WPFR +
Sbjct: 422 DGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQR 481
Query: 345 VTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDD 404
VT MLLDQ+ +++ ++ F+PD +S+SF+RP E N+ASGCP F S L++ K+AY+KDD
Sbjct: 482 VTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDD 541
Query: 405 TMFLKCIVE 413
T+FLK V+
Sbjct: 542 TLFLKVAVD 550
>gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 211 bits (536), Expect = 1e-54
Identities = 143/429 (33%), Positives = 223/429 (51%), Gaps = 81/429 (18%)
Query: 27 CQDPKEPRALCCAGCLSENPRNGEDQICPK----CRGEDLQSISPGSRLRTQEKAHPEVA 82
CQ KE C + N +N E+ +CP+ C + I L+T+ H V
Sbjct: 161 CQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKII-----LKTEVDEHLAVC 215
Query: 83 -EAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMAL 141
EA CPF GC+ +++Q+HE ++ H+ L+L Q L
Sbjct: 216 PEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQ---------------L 260
Query: 142 EQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK--EKLLAELEGKLRVF-E 198
E+ +SDL S Q+E +Q + +KL E + ++F +
Sbjct: 261 EEQISDLHK-------------------SLEQKESKIQQLAETIKKLEKEFKQFAQLFGK 301
Query: 199 NIVAVLNKEVEASHLA----LATSIHQ---------SQLD-----------RERILSLE- 233
N + N +V ASH+ L +HQ ++ D +++I LE
Sbjct: 302 NGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLEN 361
Query: 234 --QRVVELQQTLAQKDQ-------ALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESA 284
QR+ L++ + D L K E+ +L+E ++G +WK+T+ + E+
Sbjct: 362 NDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAV 421
Query: 285 CGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNK 344
G TVS+FS +FYT++ GY+LC R YLNGDG+G+ +HLSL+ V+MRGE+D+LL WPFR +
Sbjct: 422 DGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQR 481
Query: 345 VTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDD 404
VT MLLDQ+ +++ ++ F+PD +S+SF+RP E N+ASGCP F S L++ K+AY+KDD
Sbjct: 482 VTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDD 541
Query: 405 TMFLKCIVE 413
T+FLK V+
Sbjct: 542 TLFLKVAVD 550
>gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 211 bits (536), Expect = 1e-54
Identities = 143/429 (33%), Positives = 223/429 (51%), Gaps = 81/429 (18%)
Query: 27 CQDPKEPRALCCAGCLSENPRNGEDQICPK----CRGEDLQSISPGSRLRTQEKAHPEVA 82
CQ KE C + N +N E+ +CP+ C + I L+T+ H V
Sbjct: 161 CQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKII-----LKTEVDEHLAVC 215
Query: 83 -EAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMAL 141
EA CPF GC+ +++Q+HE ++ H+ L+L Q L
Sbjct: 216 PEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQ---------------L 260
Query: 142 EQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMK--EKLLAELEGKLRVF-E 198
E+ +SDL S Q+E +Q + +KL E + ++F +
Sbjct: 261 EEQISDLHK-------------------SLEQKESKIQQLAETIKKLEKEFKQFAQLFGK 301
Query: 199 NIVAVLNKEVEASHLA----LATSIHQ---------SQLD-----------RERILSLE- 233
N + N +V ASH+ L +HQ ++ D +++I LE
Sbjct: 302 NGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLEN 361
Query: 234 --QRVVELQQTLAQKDQ-------ALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHESA 284
QR+ L++ + D L K E+ +L+E ++G +WK+T+ + E+
Sbjct: 362 NDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAV 421
Query: 285 CGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNK 344
G TVS+FS +FYT++ GY+LC R YLNGDG+G+ +HLSL+ V+MRGE+D+LL WPFR +
Sbjct: 422 DGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQR 481
Query: 345 VTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDD 404
VT MLLDQ+ +++ ++ F+PD +S+SF+RP E N+ASGCP F S L++ K+AY+KDD
Sbjct: 482 VTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDD 541
Query: 405 TMFLKCIVE 413
T+FLK V+
Sbjct: 542 TLFLKVAVD 550
>gi|22027622 TNF receptor-associated factor 4 [Homo sapiens]
Length = 470
Score = 128 bits (321), Expect = 1e-29
Identities = 71/175 (40%), Positives = 105/175 (60%), Gaps = 15/175 (8%)
Query: 252 KLEQSLRLMEEASF--DGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRL 309
+L++ R +EE S DG +WKI + RR E+ + FSPAFYT KYGYKL +
Sbjct: 291 ELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSA 350
Query: 310 YLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNN-----REHAIDAFRP 364
+LNG+G+G+ THLSL+I ++ G +D LL WPF +VTF LLDQ++ +H + F P
Sbjct: 351 FLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHP 410
Query: 365 DLSSASFQRPQS------ETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVE 413
D + +FQ+P + E+++ G P F +S K YV+DD +F++ VE
Sbjct: 411 DPNWKNFQKPGTWRGSLDESSLGFGYPKF--ISHQDIRKRNYVRDDAVFIRAAVE 463
>gi|22027630 TNF receptor-associated factor 6 [Homo sapiens]
Length = 522
Score = 105 bits (261), Expect = 1e-22
Identities = 79/281 (28%), Positives = 139/281 (49%), Gaps = 38/281 (13%)
Query: 161 EVDCYRAP---------CSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEAS 211
++DC AP C E + L ++E + + + ++ + + +
Sbjct: 232 DLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISE 291
Query: 212 HLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEA-------S 264
+IHQ + R++ + ++ EL + + + +L++++R +E+
Sbjct: 292 VRNFQETIHQLE---GRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQ 348
Query: 265 FDGTFLWKITN--VTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKR--T 320
+G ++WKI N + +C E + V + SP FYT K GYKLC+RL+L T +R
Sbjct: 349 CNGIYIWKIGNFGMHLKCQEEE--KPVVIHSPGFYTGKPGYKLCMRLHLQLP-TAQRCAN 405
Query: 321 HLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQN------NREHAIDAFRPDLSSASFQRP 374
++SLF+ M+GEYD+ LPWPF+ + +LDQ+ N E +DA +P+L +FQRP
Sbjct: 406 YISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDA-KPEL--LAFQRP 462
Query: 375 QSETNVAS-GCPLFFPLSKLQSPKHAYVKDDTMFLKCIVET 414
N G F L L+ + ++KDDT+ ++C V T
Sbjct: 463 TIPRNPKGFGYVTFMHLEALR--QRTFIKDDTLLVRCEVST 501
>gi|4759254 TNF receptor-associated factor 6 [Homo sapiens]
Length = 522
Score = 105 bits (261), Expect = 1e-22
Identities = 79/281 (28%), Positives = 139/281 (49%), Gaps = 38/281 (13%)
Query: 161 EVDCYRAP---------CSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEAS 211
++DC AP C E + L ++E + + + ++ + + +
Sbjct: 232 DLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISE 291
Query: 212 HLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEA-------S 264
+IHQ + R++ + ++ EL + + + +L++++R +E+
Sbjct: 292 VRNFQETIHQLE---GRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQ 348
Query: 265 FDGTFLWKITN--VTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKR--T 320
+G ++WKI N + +C E + V + SP FYT K GYKLC+RL+L T +R
Sbjct: 349 CNGIYIWKIGNFGMHLKCQEEE--KPVVIHSPGFYTGKPGYKLCMRLHLQLP-TAQRCAN 405
Query: 321 HLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQN------NREHAIDAFRPDLSSASFQRP 374
++SLF+ M+GEYD+ LPWPF+ + +LDQ+ N E +DA +P+L +FQRP
Sbjct: 406 YISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDA-KPEL--LAFQRP 462
Query: 375 QSETNVAS-GCPLFFPLSKLQSPKHAYVKDDTMFLKCIVET 414
N G F L L+ + ++KDDT+ ++C V T
Sbjct: 463 TIPRNPKGFGYVTFMHLEALR--QRTFIKDDTLLVRCEVST 501
>gi|153070262 meprin A alpha [Homo sapiens]
Length = 746
Score = 38.5 bits (88), Expect = 0.011
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 268 TFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNG-DGTGKRTHLSLFI 326
T +W + N ++ ++ G L SP FY ++ GY + LY N + +G +L L
Sbjct: 433 TGVWTVRNFSQVLENTSKGD--KLQSPRFYNSE-GYGFGVTLYPNSRESSG---YLRLAF 486
Query: 327 VIMRGEYDALLPWPFRNK-VTFMLLDQ 352
+ GE DA+L WP N+ V +LDQ
Sbjct: 487 HVCSGENDAILEWPVENRQVIITILDQ 513
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 37.4 bits (85), Expect = 0.025
Identities = 42/151 (27%), Positives = 70/151 (46%), Gaps = 21/151 (13%)
Query: 102 QSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLE 161
+S++ EV T HL M++ RL E+ ++LE+ LS ++ AA+ G E
Sbjct: 430 ESLRIKEVEHMTRHLEESEKAMQERVQRL----EAARLSLEEELSRVKA-AALSERGQAE 484
Query: 162 VDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQ 221
+ +A EE ++ LA LE KLR ++A E + + L + +
Sbjct: 485 EELIKAKSQARLEE--------QQRLAHLEDKLR----LLAQARDEAQGACLQQKQVVAE 532
Query: 222 SQLDRER----ILSLEQRVVELQQTLAQKDQ 248
+Q + + L +R+ ELQQ L+ KDQ
Sbjct: 533 AQTRVSQLGLQVEGLRRRLEELQQELSLKDQ 563
Score = 29.3 bits (64), Expect = 6.9
Identities = 28/94 (29%), Positives = 41/94 (43%), Gaps = 7/94 (7%)
Query: 170 SESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERI 229
SES ++H + +E + RV A L+ E E S + A + Q + E I
Sbjct: 429 SESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELI 488
Query: 230 LSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEA 263
+ Q +E QQ LA LE LRL+ +A
Sbjct: 489 KAKSQARLEEQQRLAH-------LEDKLRLLAQA 515
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 36.6 bits (83), Expect = 0.043
Identities = 39/145 (26%), Positives = 68/145 (46%), Gaps = 19/145 (13%)
Query: 106 EHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCY 165
E E +QT N ++ K+ +AR+ + E S+LQ Q ++ +LE CY
Sbjct: 396 ESEYMAQTQSTNHMI---KELEARVQ------QLTGEAENSNLQRQKLIQEKAELE-RCY 445
Query: 166 RAPCSESQEELALQ---HFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQS 222
+ CSE QE A + H K+ L+ + E +++ + ++ H AL+ S S
Sbjct: 446 QITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEH-ALSASKASS 504
Query: 223 QLDRERILSLEQRVVELQQTLAQKD 247
++ LEQ V +L+Q L + +
Sbjct: 505 MIE-----ELEQNVCQLKQQLQESE 524
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 36.2 bits (82), Expect = 0.056
Identities = 39/155 (25%), Positives = 74/155 (47%), Gaps = 13/155 (8%)
Query: 135 ESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELA--LQHFMKEKLLAELEG 192
+ G ALEQ +AA E + + + S Q+ELA L+ +EK+ ELE
Sbjct: 838 QEGKTALEQQ------KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM--ELEM 889
Query: 193 KLRVFENIVAVLNKEVEASHLALATSIHQSQLDRER-ILSLEQRVVELQQTLAQKDQALG 251
+L+ + + + + E +++ Q QL+ E+ +SL + +++ Q+ LA Q L
Sbjct: 890 RLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949
Query: 252 KLEQSLRL--MEEASFDGTFLWKITNVTRRCHESA 284
+L Q +++ ++E G ++ R E+A
Sbjct: 950 RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Score = 35.8 bits (81), Expect = 0.074
Identities = 59/226 (26%), Positives = 94/226 (41%), Gaps = 28/226 (12%)
Query: 60 EDLQSIS-----PGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQ------EHE 108
EDL+ I G L TQ + E AE G G A +GS + ++ E E
Sbjct: 1683 EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ-----RGSLEHMKLILRDKEKE 1737
Query: 109 VTSQTSHLNLLLGFMKQWKARL-GCGLESGPMAL-----EQNLSDLQ--LQAAVEVAGDL 160
V Q H++ L Q + +L G + G +L EQ + LQ LQ A E G+L
Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEARE-QGEL 1796
Query: 161 EVDCYRAPCSESQEELALQHFMKEKLLAE---LEGKLRVFENIVAVLNKEVEASHLALAT 217
+ ++ E+Q LA + E L E +G+ + L +E +H+ L
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 218 SIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEA 263
+ Q +E+ LE+ + + + ++ LG L R E+A
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKA 1902
Score = 35.4 bits (80), Expect = 0.096
Identities = 46/144 (31%), Positives = 71/144 (49%), Gaps = 28/144 (19%)
Query: 145 LSDLQLQA-AVEVAGDLEVDCYRAPCSES--QEELA------LQHFMKEKLLAELEGKLR 195
L D LQA AV D E++ RA S QEE A LQ + K A L+GK +
Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG-KAHAALQGKEQ 1982
Query: 196 -VFENIVAVLNKEVEASHLALATSI-----HQSQLD----------RERILSLEQRVVEL 239
+ E A L++ +EAS L S+ H QL+ +++ L ++ V +L
Sbjct: 1983 HLLEQ--AELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQL 2040
Query: 240 QQTLAQKDQALGKLEQSLRLMEEA 263
QQ LAQ+D+ L ++ +L+E++
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKS 2064
Score = 33.5 bits (75), Expect = 0.37
Identities = 32/148 (21%), Positives = 64/148 (43%), Gaps = 11/148 (7%)
Query: 125 QWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKE 184
+W+ + LES M L + ++ LQ + +E R ++E L Q +
Sbjct: 1303 KWEGKQN-SLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
Query: 185 KLLAE----------LEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQ 234
+ E LE LR + + + N+EVE+ Q +L + +L++
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQE 1421
Query: 235 RVVELQQTLAQKDQALGKLEQSLRLMEE 262
+ L QTLA++++ + L ++ +E+
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQELEK 1449
Score = 33.5 bits (75), Expect = 0.37
Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 26/143 (18%)
Query: 127 KARLGCGLESGPMALEQNLS-----DLQLQAAVEVA-GDLEVDC--YRAPCSESQEELA- 177
+A L LE+ L+ +L QL+ A+ + G+++ Y+ + Q+ LA
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046
Query: 178 ----LQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLE 233
L+H + + L E RV EN++ E +L + + E I L
Sbjct: 2047 RDEELRHQQEREQLLEKSLAQRVQENMIQ------EKQNLG-------QEREEEEIRGLH 2093
Query: 234 QRVVELQQTLAQKDQALGKLEQS 256
Q V ELQ TLAQK+Q + +L ++
Sbjct: 2094 QSVRELQLTLAQKEQEILELRET 2116
Score = 30.8 bits (68), Expect = 2.4
Identities = 33/125 (26%), Positives = 59/125 (47%), Gaps = 16/125 (12%)
Query: 149 QLQAAVEVAGDLEVDCYRAPCSESQEE--LALQHFMKEKLLAELEGKLRVFEN------- 199
++QA EV GDL + S QE+ LALQ E+ E E + R ++
Sbjct: 1881 RVQALEEVLGDLRAE------SREQEKALLALQQQCAEQA-QEHEVETRALQDSWLQAQA 1933
Query: 200 IVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRL 259
++ ++E+EA +S HQ + R R +L++ + + L K+Q L + + R
Sbjct: 1934 VLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993
Query: 260 MEEAS 264
+E ++
Sbjct: 1994 LEAST 1998
Score = 28.9 bits (63), Expect = 9.0
Identities = 27/132 (20%), Positives = 55/132 (41%), Gaps = 9/132 (6%)
Query: 147 DLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNK 206
+ QLQ A E +L+ D E +EE+ +K L+E + + L++
Sbjct: 665 EAQLQKAEEAGAELQADL--RDIQEEKEEI-------QKKLSESRHQQEAATTQLEQLHQ 715
Query: 207 EVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFD 266
E + LA ++ + + +LE R+ +++ + L L + L+E + F+
Sbjct: 716 EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775
Query: 267 GTFLWKITNVTR 278
+ VT+
Sbjct: 776 AQQQNSVIEVTK 787
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 36.2 bits (82), Expect = 0.056
Identities = 34/126 (26%), Positives = 58/126 (46%), Gaps = 19/126 (15%)
Query: 160 LEVDCYRAPCSESQEELALQHFMKEKLLAE-----LEGKLRVFENIVAVLNKEVEASHLA 214
LE +C EL L KEK E L ++ + I+A L KE +A A
Sbjct: 945 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Query: 215 LATSIHQSQLDRERI-------LSLEQRVVELQQTLAQK-------DQALGKLEQSLRLM 260
++ Q++ +++ + LEQ+V +L+ +L Q+ ++A KLE L+L
Sbjct: 1005 HQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLT 1064
Query: 261 EEASFD 266
+E+ D
Sbjct: 1065 QESIMD 1070
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 35.8 bits (81), Expect = 0.074
Identities = 41/175 (23%), Positives = 81/175 (46%), Gaps = 19/175 (10%)
Query: 99 GSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDL-QLQAAVEVA 157
G S Q E+ + L + M++WK ++ +++ Q +L QLQA V V
Sbjct: 1197 GGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVD 1256
Query: 158 GD----LEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENI-------VAVLNK 206
D L+VD S Q E L++F +E LA+++ + N + +++
Sbjct: 1257 SDNNSKLQVDYTGLIQSYEQNETKLKNFGQE--LAQVQHSIGQLCNTKDLLLGKLDIISP 1314
Query: 207 EVEASHLALATSIHQSQLDRERILS-----LEQRVVELQQTLAQKDQALGKLEQS 256
++ ++ L S + + +LS L+Q + EL+++L +KD + L+++
Sbjct: 1315 QLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQEN 1369
Score = 29.3 bits (64), Expect = 6.9
Identities = 31/121 (25%), Positives = 60/121 (49%), Gaps = 7/121 (5%)
Query: 144 NLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHF-MKEKLLAELEGKLRVFENIVA 202
N S LQL+ + + + D A ++ E++ H K+ L + LE + ++ +
Sbjct: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQ---L 809
Query: 203 VLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKL-EQSLRLME 261
+ KE+ L +S Q +LD+ + + L+QT+ +KD++LG + E++ L E
Sbjct: 810 INKKEIFIEKLKERSSKLQEELDKYSQALRKNEI--LRQTIEEKDRSLGSMKEENNHLQE 867
Query: 262 E 262
E
Sbjct: 868 E 868
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 35.8 bits (81), Expect = 0.074
Identities = 44/196 (22%), Positives = 79/196 (40%), Gaps = 33/196 (16%)
Query: 103 SVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEV 162
S+ + ++ + HL L + + K + + M ++ L LQ Q + E ++
Sbjct: 792 SMLQQDIICKQHHLESLDRLLTESKGEM----KKENMKKDEALKALQNQVSEETIKVRQL 847
Query: 163 DCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQS 222
D C +EEL L L +LEG FE + ++EV L H
Sbjct: 848 DSALEIC---KEELVLH-------LNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSL 897
Query: 223 QLDRERILSLEQRVVELQQTLAQK--------------DQALGKLEQSLRLMEEASFDGT 268
Q E+ + L+ + + QQ L Q+ ++ + KLEQ L+ E+S +
Sbjct: 898 QETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAE-- 955
Query: 269 FLWKITNVTRRCHESA 284
K+ + +C +A
Sbjct: 956 ---KLRKMEEKCESAA 968
Score = 30.0 bits (66), Expect = 4.0
Identities = 18/79 (22%), Positives = 41/79 (51%)
Query: 184 EKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTL 243
E+ + +LEG L E + NK++E+ + L + Q + +L EQ + +L++ +
Sbjct: 1161 EQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEI 1220
Query: 244 AQKDQALGKLEQSLRLMEE 262
+ Q + ++E ++ E+
Sbjct: 1221 ERTQQRMKEMESVMKEQEQ 1239
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 35.8 bits (81), Expect = 0.074
Identities = 29/119 (24%), Positives = 56/119 (47%), Gaps = 4/119 (3%)
Query: 140 ALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFEN 199
A+ Q LQ ++ + E + Y C + L Q KEK L +LE L++ +
Sbjct: 430 AMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKE 489
Query: 200 IVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLR 258
L ++++ AL+ +++Q +I+SL++ + LQ Q + + EQ+L+
Sbjct: 490 WRQTLQEDLQKEKDALSHLRNETQ----QIISLKKEFLNLQDENQQLKKIYHEQEQALQ 544
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 35.4 bits (80), Expect = 0.096
Identities = 39/129 (30%), Positives = 66/129 (51%), Gaps = 13/129 (10%)
Query: 141 LEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRV-FEN 199
LE++LS+L+ Q A + L + + Q+E +H +E + LEGKL+ EN
Sbjct: 271 LERSLSELKNQMAEPPS--LAPPAVTSVVEQLQDEA--KHLRQE--VEGLEGKLQSQVEN 324
Query: 200 --IVAVLNKE----VEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKL 253
+++L+KE ++ L Q ++ER+ +R+ E Q+TL ++ + L K
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 254 EQSLRLMEE 262
EQ LR EE
Sbjct: 385 EQRLRKQEE 393
Score = 30.0 bits (66), Expect = 4.0
Identities = 20/96 (20%), Positives = 42/96 (43%)
Query: 171 ESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERIL 230
E E Q +++ L E +LR + + + + L + + + ER+
Sbjct: 344 EMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQ 403
Query: 231 SLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFD 266
E+R+ + ++ L +K++ L K E+ L L + D
Sbjct: 404 KQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLD 439
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 35.4 bits (80), Expect = 0.096
Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 19/126 (15%)
Query: 160 LEVDCYRAPCSESQEELALQHFMKEKLLAE-----LEGKLRVFENIVAVLNKEVEASHLA 214
LE +C EL L KEK E L ++ + I+A L KE +A A
Sbjct: 943 LEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA 1002
Query: 215 LATSIHQSQLDRERI-------LSLEQRVVELQQTLAQK-------DQALGKLEQSLRLM 260
++ Q + +++ + LEQ+V +L+ +L Q+ ++A KLE L+L
Sbjct: 1003 HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLT 1062
Query: 261 EEASFD 266
+E+ D
Sbjct: 1063 QESIMD 1068
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 35.4 bits (80), Expect = 0.096
Identities = 39/129 (30%), Positives = 66/129 (51%), Gaps = 13/129 (10%)
Query: 141 LEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRV-FEN 199
LE++LS+L+ Q A + L + + Q+E +H +E + LEGKL+ EN
Sbjct: 271 LERSLSELKNQMAEPPS--LAPPAVTSVVEQLQDEA--KHLRQE--VEGLEGKLQSQVEN 324
Query: 200 --IVAVLNKE----VEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKL 253
+++L+KE ++ L Q ++ER+ +R+ E Q+TL ++ + L K
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 254 EQSLRLMEE 262
EQ LR EE
Sbjct: 385 EQRLRKQEE 393
Score = 30.0 bits (66), Expect = 4.0
Identities = 20/96 (20%), Positives = 42/96 (43%)
Query: 171 ESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERIL 230
E E Q +++ L E +LR + + + + L + + + ER+
Sbjct: 344 EMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQ 403
Query: 231 SLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFD 266
E+R+ + ++ L +K++ L K E+ L L + D
Sbjct: 404 KQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLD 439
>gi|194294510 kinesin family member C3 isoform 2 [Homo sapiens]
Length = 826
Score = 35.4 bits (80), Expect = 0.096
Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 4/132 (3%)
Query: 131 GCGLESGPMALEQNLSDLQLQAAVE--VAGDLEVDCYRAPCSESQEELALQHFMKEKLLA 188
GC L LS LQL+ A + +L ++ + ++ EL L+ + EK
Sbjct: 170 GCEHSQESAQLRDKLSQLQLEMAESKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQE 229
Query: 189 E--LEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQK 246
E L +LR +A L + + T +S ++ + + R LQ+ +A +
Sbjct: 230 EERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQARNQHLQEQVAMQ 289
Query: 247 DQALGKLEQSLR 258
Q L ++EQ L+
Sbjct: 290 RQVLKEMEQQLQ 301
>gi|194294508 kinesin family member C3 isoform 3 [Homo sapiens]
Length = 687
Score = 35.4 bits (80), Expect = 0.096
Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 4/132 (3%)
Query: 131 GCGLESGPMALEQNLSDLQLQAAVE--VAGDLEVDCYRAPCSESQEELALQHFMKEKLLA 188
GC L LS LQL+ A + +L ++ + ++ EL L+ + EK
Sbjct: 31 GCEHSQESAQLRDKLSQLQLEMAESKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQE 90
Query: 189 E--LEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQK 246
E L +LR +A L + + T +S ++ + + R LQ+ +A +
Sbjct: 91 EERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQARNQHLQEQVAMQ 150
Query: 247 DQALGKLEQSLR 258
Q L ++EQ L+
Sbjct: 151 RQVLKEMEQQLQ 162
>gi|94536858 kinesin family member C3 isoform 1 [Homo sapiens]
Length = 833
Score = 35.4 bits (80), Expect = 0.096
Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 4/132 (3%)
Query: 131 GCGLESGPMALEQNLSDLQLQAAVE--VAGDLEVDCYRAPCSESQEELALQHFMKEKLLA 188
GC L LS LQL+ A + +L ++ + ++ EL L+ + EK
Sbjct: 170 GCEHSQESAQLRDKLSQLQLEMAESKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQE 229
Query: 189 E--LEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQK 246
E L +LR +A L + + T +S ++ + + R LQ+ +A +
Sbjct: 230 EERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQARNQHLQEQVAMQ 289
Query: 247 DQALGKLEQSLR 258
Q L ++EQ L+
Sbjct: 290 RQVLKEMEQQLQ 301
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding domain
1 [Homo sapiens]
Length = 1412
Score = 35.4 bits (80), Expect = 0.096
Identities = 27/108 (25%), Positives = 57/108 (52%), Gaps = 15/108 (13%)
Query: 167 APCSESQ-EELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLD 225
AP +ES +++A +H + + L A+ E + + ++ L K++ +H ++ + +L+
Sbjct: 978 APMTESSAKDMAYEHLIDDLLAAQKE--ILSQQEVIMKLRKDLTEAHSRMSDL--RGELN 1033
Query: 226 RERILSLEQRVVELQQT----------LAQKDQALGKLEQSLRLMEEA 263
++ + LEQ VV +QQ +AQ + K ++ L+ +EEA
Sbjct: 1034 EKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEA 1081
>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
sapiens]
Length = 693
Score = 35.4 bits (80), Expect = 0.096
Identities = 39/129 (30%), Positives = 66/129 (51%), Gaps = 13/129 (10%)
Query: 141 LEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRV-FEN 199
LE++LS+L+ Q A + L + + Q+E +H +E + LEGKL+ EN
Sbjct: 271 LERSLSELKNQMAEPPS--LAPPAVTSVVEQLQDEA--KHLRQE--VEGLEGKLQSQVEN 324
Query: 200 --IVAVLNKE----VEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKL 253
+++L+KE ++ L Q ++ER+ +R+ E Q+TL ++ + L K
Sbjct: 325 NQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQ 384
Query: 254 EQSLRLMEE 262
EQ LR EE
Sbjct: 385 EQRLRKQEE 393
Score = 30.0 bits (66), Expect = 4.0
Identities = 20/96 (20%), Positives = 42/96 (43%)
Query: 171 ESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERIL 230
E E Q +++ L E +LR + + + + L + + + ER+
Sbjct: 344 EMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQ 403
Query: 231 SLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFD 266
E+R+ + ++ L +K++ L K E+ L L + D
Sbjct: 404 KQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLD 439
>gi|51317366 myosin XVIIIB [Homo sapiens]
Length = 2567
Score = 35.0 bits (79), Expect = 0.13
Identities = 34/128 (26%), Positives = 62/128 (48%), Gaps = 19/128 (14%)
Query: 141 LEQNLSDLQ--LQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFE 198
LEQ L +LQ A ++A L+ C+ C + L++ ++ ELE K + F+
Sbjct: 1553 LEQKLGELQSAYDGAKKMAHQLKRKCHHLTCDLEDTCVLLEN--QQSRNHELEKKQKKFD 1610
Query: 199 NIVAVLNKEVEASHLALATSIHQSQLDRERIL----SLEQRVVELQQTLAQKDQALGKLE 254
+A AL S+ + L RE++ S+ + +LQQ L QK+Q +L+
Sbjct: 1611 LQLAQ----------ALGESVFEKGL-REKVTQENTSVRWELGQLQQQLKQKEQEASQLK 1659
Query: 255 QSLRLMEE 262
Q + ++++
Sbjct: 1660 QQVEMLQD 1667
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 34.7 bits (78), Expect = 0.16
Identities = 32/123 (26%), Positives = 53/123 (43%), Gaps = 5/123 (4%)
Query: 141 LEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENI 200
LEQ + LQ Q ++ L+ + + QE+L Q L E E ++ + E +
Sbjct: 267 LEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVEL-ELM 325
Query: 201 VAVLNKEVE----ASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQS 256
L E E L + + Q R+ L L++ + +L+Q L Q+ Q L + E
Sbjct: 326 PVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQ 385
Query: 257 LRL 259
L L
Sbjct: 386 LEL 388
>gi|5453726 leucine rich repeat (in FLII) interacting protein 2
isoform 1 [Homo sapiens]
Length = 721
Score = 34.7 bits (78), Expect = 0.16
Identities = 26/98 (26%), Positives = 52/98 (53%), Gaps = 7/98 (7%)
Query: 161 EVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATS-- 218
+VD + E +E++A + E+ ELE + +++ +VL ++E L
Sbjct: 399 QVDTLKDVIEEQEEQMAEFYRENEEKSKELERQ----KHMCSVLQHKMEELKEGLRQRDE 454
Query: 219 -IHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQ 255
I + Q +++I ++ + V +LQ+TL KD+ +G LE+
Sbjct: 455 LIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEK 492
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,840,620
Number of Sequences: 37866
Number of extensions: 796060
Number of successful extensions: 3169
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 2825
Number of HSP's gapped (non-prelim): 443
length of query: 416
length of database: 18,247,518
effective HSP length: 105
effective length of query: 311
effective length of database: 14,271,588
effective search space: 4438463868
effective search space used: 4438463868
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.