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Search of human proteins with 5031869
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
(638 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens] 1316 0.0
gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens] 1230 0.0
gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens] 1137 0.0
gi|4505001 LIM domain kinase 1 [Homo sapiens] 672 0.0
gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 227 3e-59
gi|110349799 testis-specific protein kinase 2 [Homo sapiens] 210 3e-54
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 124 2e-28
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 124 2e-28
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 124 2e-28
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 124 3e-28
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 122 8e-28
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 120 4e-27
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 120 4e-27
gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo sapi... 119 1e-26
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 118 2e-26
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens] 117 2e-26
gi|4758282 ephrin receptor EphA7 [Homo sapiens] 115 1e-25
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 115 2e-25
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 115 2e-25
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 114 2e-25
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 114 2e-25
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 114 2e-25
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 114 2e-25
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 114 3e-25
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 110 4e-24
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 109 9e-24
gi|33188459 B-Raf [Homo sapiens] 108 1e-23
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 108 2e-23
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s... 108 2e-23
gi|47157315 Janus kinase 3 [Homo sapiens] 107 3e-23
>gi|5031869 LIM domain kinase 2 isoform 2a [Homo sapiens]
Length = 638
Score = 1316 bits (3406), Expect = 0.0
Identities = 638/638 (100%), Positives = 638/638 (100%)
Query: 1 MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC 60
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
Sbjct: 1 MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC 60
Query: 61 PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY 120
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
Sbjct: 61 PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY 120
Query: 121 CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV 180
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
Sbjct: 121 CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV 180
Query: 181 QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV 240
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
Sbjct: 181 QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV 240
Query: 241 SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK 300
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
Sbjct: 241 SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK 300
Query: 301 EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK 360
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
Sbjct: 301 EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK 360
Query: 361 ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM 420
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
Sbjct: 361 ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM 420
Query: 421 DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER 480
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
Sbjct: 421 DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER 480
Query: 481 KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII 540
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
Sbjct: 481 KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII 540
Query: 541 GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS 600
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
Sbjct: 541 GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS 600
Query: 601 FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP 638
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
Sbjct: 601 FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP 638
>gi|8051618 LIM domain kinase 2 isoform 2b [Homo sapiens]
Length = 617
Score = 1230 bits (3183), Expect = 0.0
Identities = 601/601 (100%), Positives = 601/601 (100%)
Query: 38 FRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFA 97
FRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFA
Sbjct: 17 FRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFA 76
Query: 98 CMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPA 157
CMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPA
Sbjct: 77 CMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPA 136
Query: 158 TTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRV 217
TTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRV
Sbjct: 137 TTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRV 196
Query: 218 EEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEG 277
EEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEG
Sbjct: 197 EEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEG 256
Query: 278 TLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVL 337
TLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVL
Sbjct: 257 TLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVL 316
Query: 338 GKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK 397
GKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK
Sbjct: 317 GKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK 376
Query: 398 DKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNC 457
DKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNC
Sbjct: 377 DKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNC 436
Query: 458 LIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEM 517
LIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEM
Sbjct: 437 LIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEM 496
Query: 518 LNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFF 577
LNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFF
Sbjct: 497 LNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFF 556
Query: 578 PLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSP 637
PLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSP
Sbjct: 557 PLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSP 616
Query: 638 P 638
P
Sbjct: 617 P 617
>gi|73390140 LIM domain kinase 2 isoform 1 [Homo sapiens]
Length = 686
Score = 1137 bits (2942), Expect = 0.0
Identities = 554/554 (100%), Positives = 554/554 (100%)
Query: 38 FRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFA 97
FRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFA
Sbjct: 17 FRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFA 76
Query: 98 CMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPA 157
CMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPA
Sbjct: 77 CMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPA 136
Query: 158 TTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRV 217
TTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRV
Sbjct: 137 TTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRV 196
Query: 218 EEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEG 277
EEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEG
Sbjct: 197 EEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEG 256
Query: 278 TLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVL 337
TLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVL
Sbjct: 257 TLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVL 316
Query: 338 GKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK 397
GKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK
Sbjct: 317 GKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK 376
Query: 398 DKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNC 457
DKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNC
Sbjct: 377 DKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNC 436
Query: 458 LIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEM 517
LIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEM
Sbjct: 437 LIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEM 496
Query: 518 LNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFF 577
LNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFF
Sbjct: 497 LNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFF 556
Query: 578 PLAAICCRLEPESR 591
PLAAICCRLEPESR
Sbjct: 557 PLAAICCRLEPESR 570
>gi|4505001 LIM domain kinase 1 [Homo sapiens]
Length = 647
Score = 672 bits (1733), Expect = 0.0
Identities = 342/626 (54%), Positives = 443/626 (70%), Gaps = 27/626 (4%)
Query: 6 GEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYW 65
G ++ C CG I Q + + +N WH CFRC +C SL++ YYEKDG+L+C KDYW
Sbjct: 19 GSELPVCASCGQRIYDGQ-YLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYW 77
Query: 66 GKFGEFCHGCSLLMT-GPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKC 124
++GE CHGCS +T G MVAGE KYHPECF C++C I DGD Y LV+H+ LYCG C
Sbjct: 78 ARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHC 137
Query: 125 HNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVES-----AC-SNYAT 178
+ + V+ P+ E++ +S LP++VTL+S+PA++ G+RG SVS++ C + ++
Sbjct: 138 YYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSH 197
Query: 179 TVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHD 238
TV+V+ V+ +SP+ +N+IH GDRILEINGTP+R + ++E++ I +TS+ LQL +EHD
Sbjct: 198 TVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHD 257
Query: 239 PVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSS 298
P L L P P + R++ + RS SI +SPG S
Sbjct: 258 PHDT------LGHGLGPETSPLSSP----AYTPSGEAGSSARQKPVLRSCSIDRSPGAGS 307
Query: 299 PKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMV 358
P +D+ RSESLR +IFRP DLIHGEVLGKG FGQAIKVTH+ TG+VMV
Sbjct: 308 LGSPASQRKDLGRSESLRVVCR-PHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMV 366
Query: 359 MKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLR 418
MKELIR DEETQ+TFL EVKVMR L+HPNVLKFIGVLYKDK+LN +TEYI+GGTL+ ++
Sbjct: 367 MKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIK 426
Query: 419 SMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIV 477
SMD +PW Q+V FAK IASGMAYLHSM IIHRDLNSHNCL++ +K VVVADFGL+RL+V
Sbjct: 427 SMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMV 486
Query: 478 EERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLC 537
+E+ + R+L+K DRKKRYTVVGNPYWMAPEM+NG+SYDE VD+FSFGIVLC
Sbjct: 487 DEKTQPE------GLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC 540
Query: 538 EIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 597
EIIG+V ADPD LPRT+DFGLNV+ F +++ P +CPP+FFP+ CC L+PE RP+F KL
Sbjct: 541 EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL 600
Query: 598 EDSFEALSLYLGELGIPLPAELEELD 623
E E L ++L +PL +LE+LD
Sbjct: 601 EHWLETLRMHLAG-HLPLGPQLEQLD 625
>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
Length = 626
Score = 227 bits (578), Expect = 3e-59
Identities = 133/317 (41%), Positives = 176/317 (55%), Gaps = 25/317 (7%)
Query: 311 RSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ 370
R S R S + R D E +G GFF + KV H+ +G+VMV+K + +
Sbjct: 37 RPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLK--MNKLPSNR 94
Query: 371 KTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVR 430
L EV++M L HPN+L+F+GV +L+ LTEY+ GGTL+ L S +P W ++
Sbjct: 95 GNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLH 154
Query: 431 FAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK---TVVVADFGLSRLIVEERKRAPMEK 487
A IA G+ YLHS + HRDL S NCL++ + T VV DFGL+ I R+ A
Sbjct: 155 LALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGA---- 210
Query: 488 ATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADP 547
RK+ VVG+PYWMAPE+L G+ YDE D+F+FGIVLCE+I +V ADP
Sbjct: 211 ------------RKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADP 258
Query: 548 DCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLY 607
D LPRT DFGL+V F V DCP F LA CC LEP +R F+++ E +
Sbjct: 259 DYLPRTEDFGLDVPAF-RTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWI--- 314
Query: 608 LGELGIPLPAELEELDH 624
L +L P P L H
Sbjct: 315 LEQLPEPAPLTRTALTH 331
>gi|110349799 testis-specific protein kinase 2 [Homo sapiens]
Length = 571
Score = 210 bits (535), Expect = 3e-54
Identities = 114/279 (40%), Positives = 163/279 (58%), Gaps = 25/279 (8%)
Query: 335 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGV 394
E +G GFF + KV H+A+G+VM +K + + L EV++M L HPN+L+F+GV
Sbjct: 62 EKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMGV 119
Query: 395 LYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNS 454
+L+ LTEYI G L+ L S PW +V+ A IA G++YLH I HRDL S
Sbjct: 120 CVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTS 179
Query: 455 HNCLIKLDK---TVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 511
NCLIK D+ + VVADFGL+ I + + ++ VVG+P+
Sbjct: 180 KNCLIKRDENGYSAVVADFGLAEKIPDVSMGS------------------EKLAVVGSPF 221
Query: 512 WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTD 571
WMAPE+L + Y+E D+FS+GI+LCEII ++ ADPD LPRT +FGL+ F + + D
Sbjct: 222 WMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGD 279
Query: 572 CPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGE 610
CPP F L CC ++P+ RP+F ++ + E + L E
Sbjct: 280 CPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQE 318
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 124 bits (312), Expect = 2e-28
Identities = 89/293 (30%), Positives = 140/293 (47%), Gaps = 32/293 (10%)
Query: 321 YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGK----VMVMKELIRCDEETQKTFLTE 376
++++I C I V+G G FG+ K GK V + + E+ ++ FL E
Sbjct: 644 FAKEIEASCITIE-RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGE 702
Query: 377 VKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGI 435
+M DHPN++ GV+ K K + ++TEY+E G+L FL+ D F Q V +GI
Sbjct: 703 ASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 762
Query: 436 ASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTL 495
++GM YL M +HRDL + N LI + V+DFGLSR++
Sbjct: 763 SAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL------------------- 803
Query: 496 RKNDRKKRYTVVGNPY---WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYAD-PDCLP 551
++D + YT G W APE + + + D++S+GIV+ E++ Y + P
Sbjct: 804 -EDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS--YGERPYWEM 860
Query: 552 RTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
D V+ + P DCP A + L C + E SRP F ++ + + L
Sbjct: 861 TNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKL 913
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 124 bits (312), Expect = 2e-28
Identities = 89/293 (30%), Positives = 140/293 (47%), Gaps = 32/293 (10%)
Query: 321 YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGK----VMVMKELIRCDEETQKTFLTE 376
++++I C I V+G G FG+ K GK V + + E+ ++ FL E
Sbjct: 666 FAKEIEASCITIE-RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGE 724
Query: 377 VKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGI 435
+M DHPN++ GV+ K K + ++TEY+E G+L FL+ D F Q V +GI
Sbjct: 725 ASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 784
Query: 436 ASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTL 495
++GM YL M +HRDL + N LI + V+DFGLSR++
Sbjct: 785 SAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL------------------- 825
Query: 496 RKNDRKKRYTVVGNPY---WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYAD-PDCLP 551
++D + YT G W APE + + + D++S+GIV+ E++ Y + P
Sbjct: 826 -EDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVS--YGERPYWEM 882
Query: 552 RTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
D V+ + P DCP A + L C + E SRP F ++ + + L
Sbjct: 883 TNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKL 935
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 124 bits (312), Expect = 2e-28
Identities = 88/293 (30%), Positives = 140/293 (47%), Gaps = 41/293 (13%)
Query: 335 EVLGKGFFGQA----IKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK 390
+V+G G FG+ +K+ K V + + E+ ++ FL E +M DHPN+++
Sbjct: 625 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIR 684
Query: 391 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCIIH 449
GV+ K K + ++TEY+E G+L FLR D F Q V +GIASGM YL M +H
Sbjct: 685 LEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVH 744
Query: 450 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 509
RDL + N LI + V+DFGLSR++ ++D + YT G
Sbjct: 745 RDLAARNILINSNLVCKVSDFGLSRVL--------------------EDDPEAAYTTRGG 784
Query: 510 PY---WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQ------VYADPDCLPRTLDFGLNV 560
W +PE + + + D++S+GIVL E++ ++ D + + +D G +
Sbjct: 785 KIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVI-KAVDEGYRL 843
Query: 561 KLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGI 613
P DCP A + L C + + +RP F ++ + L G L I
Sbjct: 844 P------PPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKI 890
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 124 bits (310), Expect = 3e-28
Identities = 85/270 (31%), Positives = 128/270 (47%), Gaps = 21/270 (7%)
Query: 330 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVL 389
D+I GE+LGKG FG+ K T K V V +E + FL E K+++ DHPN++
Sbjct: 562 DVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIV 621
Query: 390 KFIGVLYKDKKLNLLTEYIEGGTLKDFL-RSMDPFPWQQKVRFAKGIASGMAYLHSMCII 448
K IGV + + + ++ E + GG FL R D +Q V+F+ A+GM YL S I
Sbjct: 622 KLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCI 681
Query: 449 HRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVG 508
HRDL + NCL+ + + ++DFG+SR + + K+ ++
Sbjct: 682 HRDLAARNCLVGENNVLKISDFGMSR----QEDGGVYSSSGLKQIPIK------------ 725
Query: 509 NPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFV 568
W APE LN Y D++SFGI+L E + P V+ +
Sbjct: 726 ---WTAPEALNYGRYSSESDVWSFGILLWETF-SLGVCPYPGMTNQQAREQVERGYRMSA 781
Query: 569 PTDCPPAFFPLAAICCRLEPESRPAFSKLE 598
P CP + C +PE+RP FS+L+
Sbjct: 782 PQHCPEDISKIMMKCWDYKPENRPKFSELQ 811
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 122 bits (307), Expect = 8e-28
Identities = 82/278 (29%), Positives = 137/278 (49%), Gaps = 27/278 (9%)
Query: 335 EVLGKGFFGQAIKVTHKATGK--VMVMKELIRC--DEETQKTFLTEVKVMRSLDHPNVLK 390
EV+G G FG+ K K GK + V + ++ E+ ++ FL+E +M DHPN+++
Sbjct: 623 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIR 682
Query: 391 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCIIH 449
GV+ K + + ++TE++E G L FLR D F Q V +GIA+GM YL M +H
Sbjct: 683 LEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVH 742
Query: 450 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 509
RDL + N L+ + V+DFGLSR + ++ + K +R
Sbjct: 743 RDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVR------------- 789
Query: 510 PYWMAPEMLNGKSYDETVDIFSFGIVLCEIIG---QVYADPDCLPRTLDFGLNVKLFWEK 566
W APE + + + D++S+GIV+ E++ + Y D D ++ +
Sbjct: 790 --WTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMS----NQDVINAIEQDYRL 843
Query: 567 FVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
P DCP A L C + + SRP F+++ ++ + +
Sbjct: 844 PPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKM 881
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 120 bits (301), Expect = 4e-27
Identities = 81/276 (29%), Positives = 134/276 (48%), Gaps = 23/276 (8%)
Query: 335 EVLGKGFFGQAIKVTHKATGK--VMVMKELIRCD--EETQKTFLTEVKVMRSLDHPNVLK 390
+V+G G FG+ K GK + V + ++ E+ ++ FL+E +M DHPNV+
Sbjct: 625 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 684
Query: 391 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCIIH 449
GV+ K + ++TE++E G+L FLR D F Q V +GIA+GM YL M +H
Sbjct: 685 LEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVH 744
Query: 450 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 509
RDL + N L+ + V+DFGLSR + ++ A K +R
Sbjct: 745 RDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIR------------- 791
Query: 510 PYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLN-VKLFWEKFV 568
W APE + + + D++S+GIV+ E++ Y + T +N ++ +
Sbjct: 792 --WTAPEAIQYRKFTSASDVWSYGIVMWEVMS--YGERPYWDMTNQDVINAIEQDYRLPP 847
Query: 569 PTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
P DCP A L C + + RP F ++ ++ + +
Sbjct: 848 PMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 883
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
sapiens]
Length = 987
Score = 120 bits (301), Expect = 4e-27
Identities = 81/276 (29%), Positives = 134/276 (48%), Gaps = 23/276 (8%)
Query: 335 EVLGKGFFGQAIKVTHKATGK--VMVMKELIRCD--EETQKTFLTEVKVMRSLDHPNVLK 390
+V+G G FG+ K GK + V + ++ E+ ++ FL+E +M DHPNV+
Sbjct: 626 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIH 685
Query: 391 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCIIH 449
GV+ K + ++TE++E G+L FLR D F Q V +GIA+GM YL M +H
Sbjct: 686 LEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVH 745
Query: 450 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 509
RDL + N L+ + V+DFGLSR + ++ A K +R
Sbjct: 746 RDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIR------------- 792
Query: 510 PYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLN-VKLFWEKFV 568
W APE + + + D++S+GIV+ E++ Y + T +N ++ +
Sbjct: 793 --WTAPEAIQYRKFTSASDVWSYGIVMWEVMS--YGERPYWDMTNQDVINAIEQDYRLPP 848
Query: 569 PTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
P DCP A L C + + RP F ++ ++ + +
Sbjct: 849 PMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 884
>gi|10140845 ephrin receptor EphA8 isoform 1 precursor [Homo
sapiens]
Length = 1005
Score = 119 bits (297), Expect = 1e-26
Identities = 87/319 (27%), Positives = 147/319 (46%), Gaps = 34/319 (10%)
Query: 296 PSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGE-VLGKGFFGQA----IKVTH 350
P EP ++ + E R S++++I IH E ++G G G+ ++V
Sbjct: 601 PGKLPEPQFYAEPHTYEEPGRAGRSFTREI--EASRIHIEKIIGSGDSGEVCYGRLRVPG 658
Query: 351 KATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG 410
+ V + E ++ FL+E +M DHPN+++ GV+ + + ++TEY+E
Sbjct: 659 QRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMEN 718
Query: 411 GTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVAD 469
G+L FLR+ D F Q V +G+ +GM YL + +HRDL + N L+ + V+D
Sbjct: 719 GSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSD 778
Query: 470 FGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY---WMAPEMLNGKSYDET 526
FGLSR++ ++D YT G W APE + +++
Sbjct: 779 FGLSRVL--------------------EDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSA 818
Query: 527 VDIFSFGIVLCEIIGQVYAD-PDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCR 585
D++SFG+V+ E++ Y + P D +V+ + P CP A L C
Sbjct: 819 SDVWSFGVVMWEVL--AYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWH 876
Query: 586 LEPESRPAFSKLEDSFEAL 604
+ RP FS++ +AL
Sbjct: 877 KDRAQRPRFSQIVSVLDAL 895
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 118 bits (295), Expect = 2e-26
Identities = 86/293 (29%), Positives = 141/293 (48%), Gaps = 32/293 (10%)
Query: 321 YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGK--VMVMKELIRCD--EETQKTFLTE 376
++++I C I +V+G G FG+ K GK + V + ++ ++ ++ FL+E
Sbjct: 612 FAKEIDASCIKIE-KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSE 670
Query: 377 VKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGI 435
+M DHPN++ GV+ K K + ++TEY+E G+L FLR D F Q V +GI
Sbjct: 671 ASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGI 730
Query: 436 ASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTL 495
SGM YL M +HRDL + N L+ + V+DFG+SR++
Sbjct: 731 GSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVL------------------- 771
Query: 496 RKNDRKKRYTVVGNPY---WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYAD-PDCLP 551
++D + YT G W APE + + + D++S+GIV+ E++ Y + P
Sbjct: 772 -EDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMS--YGERPYWDM 828
Query: 552 RTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
D ++ + P DCP A L C + E RP F ++ + + L
Sbjct: 829 SNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKL 881
>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
Length = 998
Score = 117 bits (294), Expect = 2e-26
Identities = 81/276 (29%), Positives = 132/276 (47%), Gaps = 23/276 (8%)
Query: 335 EVLGKGFFGQAIKVTHKATGK----VMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK 390
EV+G G FG+ + K G+ V + + E ++ FL+E +M DHPN+++
Sbjct: 637 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIR 696
Query: 391 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCIIH 449
GV+ K + + +LTE++E L FLR D F Q V +GIA+GM YL M +H
Sbjct: 697 LEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVH 756
Query: 450 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 509
RDL + N L+ + V+DFGLSR + ++ + K +R
Sbjct: 757 RDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIR------------- 803
Query: 510 PYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLN-VKLFWEKFV 568
W APE + + + D++S+GIV+ E++ Y + + +N V+ +
Sbjct: 804 --WTAPEAIAYRKFTSASDVWSYGIVMWEVMS--YGERPYWDMSNQDVINAVEQDYRLPP 859
Query: 569 PTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
P DCP A L C + RP FS++ ++ + L
Sbjct: 860 PMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKL 895
>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
Length = 998
Score = 115 bits (288), Expect = 1e-25
Identities = 88/309 (28%), Positives = 138/309 (44%), Gaps = 32/309 (10%)
Query: 316 RCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGK----VMVMKELIRCDEETQK 371
R +++++ C I V+G G FG+ K GK V + + E+ ++
Sbjct: 619 RAVHQFAKELDASCIKIE-RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRR 677
Query: 372 TFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVR 430
FL E +M DHPNV+ GV+ + K + ++ E++E G L FLR D F Q V
Sbjct: 678 DFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVG 737
Query: 431 FAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATT 490
+GIA+GM YL M +HRDL + N L+ + V+DFGLSR+I
Sbjct: 738 MLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI-------------- 783
Query: 491 KKRTLRKNDRKKRYTVVGNPY---WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYAD- 546
++D + YT G W APE + + + D++S+GIV+ E++ Y +
Sbjct: 784 ------EDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS--YGER 835
Query: 547 PDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSL 606
P D ++ + P DCP L C + E RP F ++ + +
Sbjct: 836 PYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIR 895
Query: 607 YLGELGIPL 615
L PL
Sbjct: 896 NPNSLKTPL 904
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 115 bits (287), Expect = 2e-25
Identities = 109/440 (24%), Positives = 183/440 (41%), Gaps = 60/440 (13%)
Query: 193 NNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTS------QTLQLLIEH-----DPVS 241
N HP +R+ + V ++ ++ A+ + + LQ +EH P
Sbjct: 282 NEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPV 341
Query: 242 QRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKE 301
L R + + G L L K ++ G R + +++ + G P
Sbjct: 342 LLLQDDRHSTSSSEQEREGGRTPTLEIL--KSHISGIFRPKF----SNLYRLEGEGFPSI 395
Query: 302 PLLFSRDISRSESLRCSSSY--------SQQIFRPCDLIHGEVLGKGFFGQAIKVTHKAT 353
PLL +S + L S + + DL+ GE +G+G FG+ +A
Sbjct: 396 PLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRAD 455
Query: 354 GKVMVMKELIRCDE----ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIE 409
++ +K C E + + FL E ++++ HPN+++ IGV + + + ++ E ++
Sbjct: 456 NTLVAVKS---CRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQ 512
Query: 410 GGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVA 468
GG FLR+ + ++ A+GM YL S C IHRDL + NCL+ + ++
Sbjct: 513 GGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKIS 572
Query: 469 DFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVD 528
DFG+SR EE ++ ++ W APE LN Y D
Sbjct: 573 DFGMSR---EEADGVYAASGGLRQVPVK---------------WTAPEALNYGRYSSESD 614
Query: 529 IFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKF----VPTDCPPAFFPLAAICC 584
++SFGI+L E + A P P + + F EK P CP A F L C
Sbjct: 615 VWSFGILLWETF-SLGASP--YPNLSN--QQTREFVEKGGRLPCPELCPDAVFRLMEQCW 669
Query: 585 RLEPESRPAFSKLEDSFEAL 604
EP RP+FS + +++
Sbjct: 670 AYEPGQRPSFSTIYQELQSI 689
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 115 bits (287), Expect = 2e-25
Identities = 109/440 (24%), Positives = 183/440 (41%), Gaps = 60/440 (13%)
Query: 193 NNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTS------QTLQLLIEH-----DPVS 241
N HP +R+ + V ++ ++ A+ + + LQ +EH P
Sbjct: 340 NEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPV 399
Query: 242 QRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKE 301
L R + + G L L K ++ G R + +++ + G P
Sbjct: 400 LLLQDDRHSTSSSEQEREGGRTPTLEIL--KSHISGIFRPKF----SNLYRLEGEGFPSI 453
Query: 302 PLLFSRDISRSESLRCSSSY--------SQQIFRPCDLIHGEVLGKGFFGQAIKVTHKAT 353
PLL +S + L S + + DL+ GE +G+G FG+ +A
Sbjct: 454 PLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRAD 513
Query: 354 GKVMVMKELIRCDE----ETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIE 409
++ +K C E + + FL E ++++ HPN+++ IGV + + + ++ E ++
Sbjct: 514 NTLVAVKS---CRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQ 570
Query: 410 GGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVA 468
GG FLR+ + ++ A+GM YL S C IHRDL + NCL+ + ++
Sbjct: 571 GGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKIS 630
Query: 469 DFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVD 528
DFG+SR EE ++ ++ W APE LN Y D
Sbjct: 631 DFGMSR---EEADGVYAASGGLRQVPVK---------------WTAPEALNYGRYSSESD 672
Query: 529 IFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKF----VPTDCPPAFFPLAAICC 584
++SFGI+L E + A P P + + F EK P CP A F L C
Sbjct: 673 VWSFGILLWETF-SLGASP--YPNLSN--QQTREFVEKGGRLPCPELCPDAVFRLMEQCW 727
Query: 585 RLEPESRPAFSKLEDSFEAL 604
EP RP+FS + +++
Sbjct: 728 AYEPGQRPSFSTIYQELQSI 747
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 114 bits (286), Expect = 2e-25
Identities = 76/225 (33%), Positives = 111/225 (49%), Gaps = 26/225 (11%)
Query: 375 TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKG 434
T++K +R L HPN++ F GV + +L E+ G L + LR+ P V ++ G
Sbjct: 160 TDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMG 219
Query: 435 IASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRT 494
IA GM YLH IIHRDL S N LI D V ++DFG S+ +
Sbjct: 220 IAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKEL------------------ 261
Query: 495 LRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQV-YADPDCLPR 552
+D+ + + G WMAPE++ + E VDI+SFG+VL E++ G++ Y D D
Sbjct: 262 ---SDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAI 318
Query: 553 TLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 597
G N VP+ CP F L C +P +RP+F ++
Sbjct: 319 IWGVGSN---SLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI 360
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 114 bits (286), Expect = 2e-25
Identities = 93/316 (29%), Positives = 147/316 (46%), Gaps = 54/316 (17%)
Query: 328 PCDLIHGEVLGKGFFGQAIKVTHK-ATGKVMV---MKELIRCDEETQKT-FLTEVKVMRS 382
P + +V+G G FG+ K K ++GK V +K L E Q+ FL E +M
Sbjct: 610 PSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQ 669
Query: 383 LDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAY 441
H N+++ GV+ K K + ++TEY+E G L FLR D F Q V +GIA+GM Y
Sbjct: 670 FSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKY 729
Query: 442 LHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRK 501
L +M +HRDL + N L+ + V+DFGLSR++ ++D +
Sbjct: 730 LANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVL--------------------EDDPE 769
Query: 502 KRYTVVGNPY---WMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDC-------LP 551
YT G W APE ++ + + D++SFGIV+ E++ Y + +
Sbjct: 770 ATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVM--TYGERPYWELSNHEVM 827
Query: 552 RTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFS----------KLEDSF 601
+ ++ G + P DCP A + L C + E RP F+ + DS
Sbjct: 828 KAINDGFRLP------TPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSL 881
Query: 602 EALSLYLGELGIPLPA 617
+ L+ + + I LP+
Sbjct: 882 KTLADFDPRVSIRLPS 897
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 114 bits (286), Expect = 2e-25
Identities = 92/346 (26%), Positives = 153/346 (44%), Gaps = 43/346 (12%)
Query: 276 EGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSY--------SQQIFR 327
+G R ++ +++ + G P PLL +S + L S + +
Sbjct: 440 DGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLN 499
Query: 328 PCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDE----ETQKTFLTEVKVMRSL 383
DL+ GE +G+G FG+ +A ++ +K C E + + FL E ++++
Sbjct: 500 HEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS---CRETLPPDLKAKFLQEARILKQY 556
Query: 384 DHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYL 442
HPN+++ IGV + + + ++ E ++GG FLR+ + ++ A+GM YL
Sbjct: 557 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYL 616
Query: 443 HSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKK 502
S C IHRDL + NCL+ + ++DFG+SR EE ++ ++
Sbjct: 617 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSR---EEADGVYAASGGLRQVPVK------ 667
Query: 503 RYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKL 562
W APE LN Y D++SFGI+L E + A P P + +
Sbjct: 668 ---------WTAPEALNYGRYSSESDVWSFGILLWETF-SLGASP--YPNLSN--QQTRE 713
Query: 563 FWEKF----VPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
F EK P CP A F L C EP RP+FS + +++
Sbjct: 714 FVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 759
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 114 bits (286), Expect = 2e-25
Identities = 92/346 (26%), Positives = 153/346 (44%), Gaps = 43/346 (12%)
Query: 276 EGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSY--------SQQIFR 327
+G R ++ +++ + G P PLL +S + L S + +
Sbjct: 498 DGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLN 557
Query: 328 PCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDE----ETQKTFLTEVKVMRSL 383
DL+ GE +G+G FG+ +A ++ +K C E + + FL E ++++
Sbjct: 558 HEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKS---CRETLPPDLKAKFLQEARILKQY 614
Query: 384 DHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYL 442
HPN+++ IGV + + + ++ E ++GG FLR+ + ++ A+GM YL
Sbjct: 615 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYL 674
Query: 443 HSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKK 502
S C IHRDL + NCL+ + ++DFG+SR EE ++ ++
Sbjct: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSR---EEADGVYAASGGLRQVPVK------ 725
Query: 503 RYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKL 562
W APE LN Y D++SFGI+L E + A P P + +
Sbjct: 726 ---------WTAPEALNYGRYSSESDVWSFGILLWETF-SLGASP--YPNLSN--QQTRE 771
Query: 563 FWEKF----VPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
F EK P CP A F L C EP RP+FS + +++
Sbjct: 772 FVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 817
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 114 bits (285), Expect = 3e-25
Identities = 81/278 (29%), Positives = 128/278 (46%), Gaps = 27/278 (9%)
Query: 335 EVLGKGFFGQAIKVTHKATGK----VMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK 390
EV+G G FG+ + KA GK V + E ++ FL+E +M +HPN+++
Sbjct: 619 EVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIR 678
Query: 391 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCIIH 449
GV+ + +LTE++E G L FLR D F Q V +GIASGM YL M +H
Sbjct: 679 LEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVH 738
Query: 450 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 509
RDL + N L+ + V+DFGLSR + E + K +R
Sbjct: 739 RDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIR------------- 785
Query: 510 PYWMAPEMLNGKSYDETVDIFSFGIVLCEIIG---QVYADPDCLPRTLDFGLNVKLFWEK 566
W APE + + + D +S+GIV+ E++ + Y D D ++ +
Sbjct: 786 --WTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMS----NQDVINAIEQDYRL 839
Query: 567 FVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 604
P DCP + L C + + +RP F ++ + + +
Sbjct: 840 PPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKM 877
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 110 bits (275), Expect = 4e-24
Identities = 89/317 (28%), Positives = 136/317 (42%), Gaps = 28/317 (8%)
Query: 330 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDE--ETQKTFLTEVKVMRSLDHPN 387
D + L G FG+ H+ G +M+MK + + E + L E K+M L H
Sbjct: 16 DFLESAELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 74
Query: 388 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCI 447
V+K +GV+ ++ K +L+ EY+E G L L++ P K R I GM YLH +
Sbjct: 75 VVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGV 134
Query: 448 IHRDLNSHNCLIKLDKTVVVADFGL------SRLIVEERKRAPMEKATTKKRTLRKNDRK 501
IH+DL N L+ D + +AD GL S+L EE T KK
Sbjct: 135 IHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG------- 187
Query: 502 KRYTVVGNPYWMAPEMLN--GKSYDETVDIFSFGIVLCEIIG--QVYADPDCLPRTLDFG 557
G Y+MAPE LN E D++SF +VL I + Y + C + +
Sbjct: 188 ------GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCI 241
Query: 558 LNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPA 617
+ + CP L +C PE+RP F +E+ F YL +L +
Sbjct: 242 KSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFR--PFYLSQLEESVEE 299
Query: 618 ELEELDHTVSMQYGLTR 634
+++ L S + + +
Sbjct: 300 DVKSLKKEYSNENAVVK 316
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 109 bits (272), Expect = 9e-24
Identities = 64/209 (30%), Positives = 107/209 (51%), Gaps = 26/209 (12%)
Query: 337 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 396
LG G FG+ K +K TG + K + EE + ++ E++++ + DHP ++K +G Y
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY 101
Query: 397 KDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVR-FAKGIASGMAYLHSMCIIHRDLNSH 455
D KL ++ E+ GG + + +D + +++ + + + +LHS IIHRDL +
Sbjct: 102 HDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAG 161
Query: 456 NCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAP 515
N L+ L+ + +ADFG+S +TL+K D + +G PYWMAP
Sbjct: 162 NVLMTLEGDIRLADFGVS---------------AKNLKTLQKRD-----SFIGTPYWMAP 201
Query: 516 EM-----LNGKSYDETVDIFSFGIVLCEI 539
E+ + YD DI+S GI L E+
Sbjct: 202 EVVMCETMKDTPYDYKADIWSLGITLIEM 230
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 108 bits (271), Expect = 1e-23
Identities = 97/352 (27%), Positives = 151/352 (42%), Gaps = 59/352 (16%)
Query: 283 SLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFF 342
SL ++ KSPGP ++ S D +R ++L S + G+ +G G F
Sbjct: 409 SLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSF 468
Query: 343 GQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLN 402
G K V ++ ++ Q F EV V+R H N+L F+G K + L
Sbjct: 469 GTVYKGKWHGDVAVKMLNVTAPTPQQLQ-AFKNEVGVLRKTRHVNILLFMGYSTKPQ-LA 526
Query: 403 LLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKL 461
++T++ EG +L L ++ F + + A+ A GM YLH+ IIHRDL S+N +
Sbjct: 527 IVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE 586
Query: 462 DKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPE---ML 518
D TV + DFGL AT K R + ++ + G+ WMAPE M
Sbjct: 587 DLTVKIGDFGL---------------ATVKSRWSGSHQFEQ---LSGSILWMAPEVIRMQ 628
Query: 519 NGKSYDETVDIFSFGIVLCEI-------------------IGQVYADPDCLPRTLDFGLN 559
+ Y D+++FGIVL E+ +G+ Y PD
Sbjct: 629 DKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDL---------- 678
Query: 560 VKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGEL 611
V ++CP A L A C + + + RP F ++ S E L+ L ++
Sbjct: 679 ------SKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI 724
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 108 bits (270), Expect = 2e-23
Identities = 73/283 (25%), Positives = 133/283 (46%), Gaps = 33/283 (11%)
Query: 321 YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKA--TGKVMVMKELIRCDEETQKTFLTEVK 378
Y + + P +L + +G G FG + H K V + IR +++ F+ E +
Sbjct: 353 YGKWVIDPSELTFVQEIGSGQFG----LVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAE 408
Query: 379 VMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIAS 437
VM L HP +++ GV + + L+ E++E G L D+LR+ F + + +
Sbjct: 409 VMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCE 468
Query: 438 GMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRK 497
GMAYL C+IHRDL + NCL+ ++ + V+DFG++R +++++ +T K ++
Sbjct: 469 GMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ----YTSSTGTKFPVK- 523
Query: 498 NDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQ---VYADPDCLPRTL 554
W +PE+ + Y D++SFG+++ E+ + Y +
Sbjct: 524 --------------WASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVE 569
Query: 555 DFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 597
D +L+ + T + + C + PE RPAFS+L
Sbjct: 570 DISTGFRLYKPRLASTH----VYQIMNHCWKERPEDRPAFSRL 608
>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
sapiens]
Length = 1400
Score = 108 bits (269), Expect = 2e-23
Identities = 94/314 (29%), Positives = 143/314 (45%), Gaps = 34/314 (10%)
Query: 336 VLGKGFFGQAI--KVTHKATGKVM-VMKELIRCDEETQ-KTFLTEVKVMRSLDHPNVLKF 391
V+GKG FG + +A ++ +K L R E Q + FL E +MR L+HPNVL
Sbjct: 1087 VIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLAL 1146
Query: 392 IGVLYKDKKL-NLLTEYIEGGTLKDFLRSMDPFPW-QQKVRFAKGIASGMAYLHSMCIIH 449
IG++ + L ++L Y+ G L F+RS P + + F +A GM YL +H
Sbjct: 1147 IGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVH 1206
Query: 450 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 509
RDL + NC++ TV VADFGL+R I++ + + R R V
Sbjct: 1207 RDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQ------------HRHARLPV--- 1251
Query: 510 PYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQ-----VYADPDCLPRTLDFGLNVKLFW 564
WMA E L + D++SFG++L E++ + + DP L L G +
Sbjct: 1252 -KWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLP--- 1307
Query: 565 EKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL-SLYLGELGIPLPAELEELD 623
P CP + + + C +P RP F L E + S LG+ + LPA L
Sbjct: 1308 ---QPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLG 1364
Query: 624 HTVSMQYGLTRDSP 637
+ S + + + P
Sbjct: 1365 PSTSHEMNVRPEQP 1378
>gi|47157315 Janus kinase 3 [Homo sapiens]
Length = 1124
Score = 107 bits (267), Expect = 3e-23
Identities = 86/307 (28%), Positives = 135/307 (43%), Gaps = 51/307 (16%)
Query: 325 IFRPCDLIHGEVLGKGFFGQAIKVTHKA----TGKVMVMKELIRCDEETQKTFLTEVKVM 380
IF L + LGKG FG + TG ++ +K+L + Q+ F E++++
Sbjct: 816 IFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQIL 875
Query: 381 RSLDHPNVLKFIGVLYKD--KKLNLLTEYIEGGTLKDFL-RSMDPFPWQQKVRFAKGIAS 437
++L ++K+ GV Y + L L+ EY+ G L+DFL R + + ++ I
Sbjct: 876 KALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICK 935
Query: 438 GMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRK 497
GM YL S +HRDL + N L++ + V +ADFGL++L+ P++
Sbjct: 936 GMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL-------PLD----------- 977
Query: 498 NDRKKRYTVVGNP-----YWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLP- 551
K Y VV P +W APE L+ + D++SFG+VL E+ Y D C P
Sbjct: 978 ----KDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELF--TYCDKSCSPS 1031
Query: 552 ----RTLDFGLNVKLFWEKF----------VPTDCPPAFFPLAAICCRLEPESRPAFSKL 597
R + +V P CP L +C P+ RP+FS L
Sbjct: 1032 AEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 1091
Query: 598 EDSFEAL 604
+ L
Sbjct: 1092 GPQLDML 1098
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,618,390
Number of Sequences: 37866
Number of extensions: 1213878
Number of successful extensions: 6428
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 771
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 3545
Number of HSP's gapped (non-prelim): 1434
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.