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Search of human proteins with 4885583
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885583 Rho-associated, coiled-coil containing protein
kinase 1 [Homo sapiens]
(1354 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 2689 0.0
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 1765 0.0
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 484 e-136
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 476 e-134
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 449 e-126
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 434 e-121
gi|32698688 citron [Homo sapiens] 433 e-121
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 365 e-100
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 365 e-100
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 362 1e-99
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 348 2e-95
gi|239752561 PREDICTED: similar to Rho-associated, coiled-coil c... 309 1e-83
gi|239745983 PREDICTED: similar to Rho-associated, coiled-coil c... 255 2e-67
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 228 3e-59
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 228 4e-59
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 223 7e-58
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 223 1e-57
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 223 1e-57
gi|148727255 microtubule associated serine/threonine kinase fami... 223 1e-57
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 221 5e-57
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 219 2e-56
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 218 2e-56
gi|4826948 protein kinase, X-linked [Homo sapiens] 218 4e-56
gi|28557781 protein kinase C, eta [Homo sapiens] 204 6e-52
gi|4885563 protein kinase C, epsilon [Homo sapiens] 201 5e-51
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 201 5e-51
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 200 7e-51
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 200 7e-51
gi|4502023 AKT2 kinase [Homo sapiens] 198 3e-50
gi|5453976 protein kinase C, theta [Homo sapiens] 197 4e-50
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 2689 bits (6969), Expect = 0.0
Identities = 1354/1354 (100%), Positives = 1354/1354 (100%)
Query: 1 MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK 60
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
Sbjct: 1 MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK 60
Query: 61 DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF 120
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
Sbjct: 61 DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF 120
Query: 121 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA 180
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
Sbjct: 121 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA 180
Query: 181 EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY 240
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
Sbjct: 181 EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY 240
Query: 241 ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 300
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
Sbjct: 241 ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 300
Query: 301 DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS 360
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
Sbjct: 301 DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS 360
Query: 361 SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA 420
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
Sbjct: 361 SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA 420
Query: 421 DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST 480
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
Sbjct: 421 DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST 480
Query: 481 VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL 540
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
Sbjct: 481 VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL 540
Query: 541 SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTD 600
SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTD
Sbjct: 541 SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTD 600
Query: 601 KDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLN 660
KDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLN
Sbjct: 601 KDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLN 660
Query: 661 HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL 720
HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
Sbjct: 661 HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL 720
Query: 721 KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQES 780
KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQES
Sbjct: 721 KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQES 780
Query: 781 NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR 840
NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
Sbjct: 781 NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR 840
Query: 841 ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE 900
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE
Sbjct: 841 ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE 900
Query: 901 SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENE 960
SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENE
Sbjct: 901 SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENE 960
Query: 961 ELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK 1020
ELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK
Sbjct: 961 ELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK 1020
Query: 1021 KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL 1080
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL
Sbjct: 1021 KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL 1080
Query: 1081 ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKK 1140
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKK
Sbjct: 1081 ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKK 1140
Query: 1141 QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY 1200
QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY
Sbjct: 1141 QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY 1200
Query: 1201 ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALE 1260
ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALE
Sbjct: 1201 ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALE 1260
Query: 1261 CRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP 1320
CRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP
Sbjct: 1261 CRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP 1320
Query: 1321 PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS 1354
PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS
Sbjct: 1321 PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS 1354
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 1765 bits (4571), Expect = 0.0
Identities = 892/1358 (65%), Positives = 1093/1358 (80%), Gaps = 27/1358 (1%)
Query: 9 TRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRD 68
+R K++ L+RDP+S +N + LLDGL++LV DLDFPALRKNKNIDNFL+RY+ + KIR
Sbjct: 25 SRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRG 84
Query: 69 LRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIM 128
L+MKAEDY+VVKVIGRGAFGEVQLVRHK+++KVYAMKLLSKFEMIKRSDSAFFWEERDIM
Sbjct: 85 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIM 144
Query: 129 AFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDA 188
AFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWA+FYTAEVVLALDA
Sbjct: 145 AFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDA 204
Query: 189 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS 248
IHSMG IHRDVKPDNMLLDK GHLKLADFGTCMKM++ GMV CDTAVGTPDYISPEVLKS
Sbjct: 205 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 264
Query: 249 QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKE 308
QGGDG+YGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM+HKNSL FP+D +ISK
Sbjct: 265 QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKH 324
Query: 309 AKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNF 368
AKNLICAFLTDREVRLGRNGVEEI++H FFKNDQW W+ +R+T APVVP+LSSDID+SNF
Sbjct: 325 AKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNF 384
Query: 369 DDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQES- 427
DD+E+DKG+ ETFPIPKAFVGNQLPF+GFTYY LS +P+ T S + +ES
Sbjct: 385 DDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSD-SPSCRETDSIQSRKNEESQ 443
Query: 428 -LQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEK 486
+QK +Y LEE L NEMQ K+E+EQKC++ N +L+K KEL+EE R+++ES + Q+E+
Sbjct: 444 EIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLER 503
Query: 487 EKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQ 546
EK LLQH+ EYQRKA+ E +K+RN+EN+V++LKDQLEDLKK +QNSQ++ EK++QLQ+Q
Sbjct: 504 EKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQ 563
Query: 547 LEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQL 606
L+E N LLRTESDTA RLRK+ E SK I QLES NR+LQ++N +LE +K + +K++ L
Sbjct: 564 LDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINL 623
Query: 607 QAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEK 666
Q+ LE+ERRDR H SE+I DLQ RI L+E++K+ K L KVE E+++ Q+ EKEK
Sbjct: 624 QSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEK 683
Query: 667 NNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDK---HQSIEEAKSVAMCEMEKKLKEE 723
+N+EID+ Y+LK +QQ LEQE EHK TKARL DK ++SIEEAKS AM EMEKKL EE
Sbjct: 684 SNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEE 743
Query: 724 REAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783
R ++K EN +++ EK+CS+LD DLKQSQQK+ L K+ + ++V+NLTL++EQE+ KR
Sbjct: 744 RTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKR 803
Query: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843
L QN+LK Q + + LK EKQ+KQE N L+E K LE + A+L K+ + +GQM+ELQ
Sbjct: 804 CLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQ 863
Query: 844 DQLEAEQYFSTLYKTQVKELKEEIEEK---NRENLKKIQELQNEKETLATQLDLAETKAE 900
DQLEAEQYFSTLYKTQV+ELKEE EEK +E +K QELQ+E+++LA QL++ TKA+
Sbjct: 864 DQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKAD 923
Query: 901 SEQLARGLLEEQYFELTQES-------KKAASRNRQEITDKDHTVSRLEEANSMLTKDIE 953
SEQLAR + EEQY +L +E K+ +R++QE+T+KD T++ LEE N LT D+
Sbjct: 924 SEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVA 983
Query: 954 ILRRENEELTEKMKKAEEEYKLEKEEEIS--NLKAAFEKNINTERTLKTQAVNKLAEIMN 1011
L E EEL K+K +E+ K+EEIS +KA FEK + TERTLKTQAVNKLAEIMN
Sbjct: 984 NLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMN 1043
Query: 1012 RKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECA 1071
RK+ K+ N D+R+KEKENRKL +EL EREK Q ++K+QKELN+MQAQ+ EE
Sbjct: 1044 RKE---PVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQ 1100
Query: 1072 HRNELQMQLASKESDIEQLRAKLLDLS---DSTSVASFPSADETDGNLPESRIEGWLSVP 1128
R ELQM L SK+SDIEQLR++L L DS+S+ S P E D PESR+EGWLS+P
Sbjct: 1101 IRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLP 1160
Query: 1129 NRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAE 1188
R N K++GW K+YV+VSSKKILFY+ EQDKEQSNP MVLDIDKLFHVRPVTQ DVYRA+
Sbjct: 1161 VRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRAD 1220
Query: 1189 TEEIPKIFQILYANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKP 1248
+EIP+IFQILYANEGE +K+ E EK+N+ HKGHEFIPTLYHFP NC+AC KP
Sbjct: 1221 AKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKP 1280
Query: 1249 LWHVFKPPPALECRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKW 1308
LWH+FKPPPALECRRCH+KCH+DH+DKKE++I PCKV YD+++A+++LLLA S +EQ+KW
Sbjct: 1281 LWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKW 1340
Query: 1309 VTHLVKKIPKNPPS--GFVRASPRTLSTRSTANQSFRK 1344
V+ LVKKIPK PP+ F R+SPRT S + NQS R+
Sbjct: 1341 VSRLVKKIPKKPPAPDPFARSSPRT-SMKIQQNQSIRR 1377
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 484 bits (1247), Expect = e-136
Identities = 373/1280 (29%), Positives = 643/1280 (50%), Gaps = 190/1280 (14%)
Query: 6 SFETRFEKMDNLLRDP----KSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKD 61
S + R +K++ LL D +S ++ + LLD L L + ALR++K + FL K
Sbjct: 2 SAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKP 61
Query: 62 TINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFF 121
++++++ ED+E++KVIGRGAFGEV +V+ K+T ++YAMK+L+K+EM+KR+++A F
Sbjct: 62 FTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACF 121
Query: 122 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYT 179
EERD++ + W+ L YAFQD+ +LY+VM+Y GGDL+ L+S ++ +PE ARFY
Sbjct: 122 REERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYI 181
Query: 180 AEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPD 239
E+VLA+D+IH + ++HRD+KPDN+LLD +GH++LADFG+C+KMN +G V+ AVGTPD
Sbjct: 182 GEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPD 241
Query: 240 YISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLT 298
YISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIMNH+
Sbjct: 242 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQ 301
Query: 299 FPDD-NDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVP 357
FP D+S+EAK+LI + RE RLG+NG+E+ K+H FF+ W E +R+ AP +P
Sbjct: 302 FPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNW--ENIRNLEAPYIP 359
Query: 358 DLSSDIDTSNFDDLEEDKGEEETFPIPK--AFVGNQLPFVGFTY-----YSNRRYLSSAN 410
D+SS DTSNFD ++ E P F G LPF+GFT+ +S+R L S
Sbjct: 360 DVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIM 419
Query: 411 PNDNRTSS-NADKSLQESLQKTIY--KLEEQLHNEMQLKDEMEQKCRT-----------S 456
++ T + + L+ SLQ Y ++ +++L ++++ +T S
Sbjct: 420 QSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALS 479
Query: 457 NIKLDKIMKELDEEGNQRRN-----------LESTVS-QIEKEKMLLQHRINEYQRKA-- 502
N DK +K+L+EE + +N LE TV+ + E+E + R E Q +
Sbjct: 480 NSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVR 539
Query: 503 EQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAV 562
+++ E + + LK Q ++LK Q +LA ++ S+L +++ E LR +
Sbjct: 540 QEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAE----LRAQKQKVS 595
Query: 563 R-LRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEA--ERRDRGH 619
R LR EM + +++++ +E++ ++ + ++Q D A+ EA ER+ R H
Sbjct: 596 RQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLD------DAVAEASKERKLREH 649
Query: 620 DSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKS 679
+++ + +L KV+ + A L H ++ +
Sbjct: 650 SENFCKQMESELEAL------------KVKQGGRGAGATLEHQQE------------ISK 685
Query: 680 LQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEK 739
++ LE++V ++ R H + E K+V KK + E+ + A ++K
Sbjct: 686 IKSELEKKVLFYEEELVRREASH--VLEVKNV------KKEVHDSESHQLA------LQK 731
Query: 740 QCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQE------SNKRLLLQNELKTQ 793
+ ML L++S+++ + ME+ V + + E+E NK+L +NE K
Sbjct: 732 EILMLKDKLEKSKRERHN------EMEEAVGTIKDKYERERAMLFDENKKLTAENE-KLC 784
Query: 794 AFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFS 853
+F D L +Q++ E+ L K + AQ+ + ++ + D+ +A Y
Sbjct: 785 SF-VDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEI-------IQWVSDEKDARGYLQ 836
Query: 854 TLYKTQVKELK----EEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLL 909
L +EL+ + + + L K++ +++K ++ +L+L ++ E+E A+ L+
Sbjct: 837 ALASKMTEELEALRSSSLGSRTLDPLWKVR--RSQKLDMSARLEL-QSALEAEIRAKQLV 893
Query: 910 EEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKM--- 966
+E+ + ++++AN L ++ +N EL E+M
Sbjct: 894 QEE-------------------------LRKVKDANLTLESKLKDSEAKNRELLEEMEIL 928
Query: 967 -KKAEEEYKLEKEEEISNLKAAFEKNINT-----ERTLKTQAVNKLAEIMNRKDFKIDRK 1020
KK EE+++ + ++ + + + + NT + T +T + ++ + +
Sbjct: 929 KKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASEQETQAPKPEASPSMS 988
Query: 1021 KANTQ---DLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQ 1077
A ++ D+ + + + L Q HQ + + +C+H L
Sbjct: 989 VAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPT--QCSHCTSLM 1046
Query: 1078 MQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPE---------------SRIE 1122
+ L + E S + V+ A + PE + +
Sbjct: 1047 VGLIRQGYACEVC-------SFACHVSCKDGAPQVCPIPPEQSKRPLGVDVQRGIGTAYK 1099
Query: 1123 GWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSN---PSMVLDI-DKLFHVRP 1178
G + VP +K+ GW++ Y VV K+ Y+ + K S VLD+ D F V
Sbjct: 1100 GHVKVPKPTGVKK-GWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSS 1158
Query: 1179 VTQGDVYRAETEEIPKIFQI 1198
V DV A +IP IF++
Sbjct: 1159 VLASDVIHATRRDIPCIFRV 1178
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 476 bits (1224), Expect = e-134
Identities = 367/1255 (29%), Positives = 612/1255 (48%), Gaps = 146/1255 (11%)
Query: 6 SFETRFEKMDNLLRDPKSEVNSDC-----LLDGLDALVYDLDFPALRKNKNIDNFLSRYK 60
S E R +++ + D ++ N C LLD L L + + LR+ KNI +L K
Sbjct: 2 SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAK 61
Query: 61 DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF 120
+K++ +R+ ED+E++KVIGRGAFGEV +V+ K+ KV+AMK+L+K+EM+KR+++A
Sbjct: 62 PFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC 121
Query: 121 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFY 178
F EERD++ ++ W+ L YAFQDD LY+VM+Y GGDL+ L+S ++ +PE ARFY
Sbjct: 122 FREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFY 181
Query: 179 TAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTP 238
AE+V+A+D++H + ++HRD+KPDN+L+D +GH++LADFG+C+K+ ++G V+ AVGTP
Sbjct: 182 LAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 241
Query: 239 DYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSL 297
DYISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIMNHK
Sbjct: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
Query: 298 TFPDD-NDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVV 356
FP D+S+ AK+LI + RE RLG+NG+E+ K+H FF W+ +R+ AP +
Sbjct: 302 QFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID--WDNIRNCEAPYI 359
Query: 357 PDLSSDIDTSNFDDLEEDKGEEETFPIP--KAFVGNQLPFVGFTYYSN--RRYLSSANPN 412
P++SS DTSNFD ++ ET P P AF G+ LPFVGFTY S+ S
Sbjct: 360 PEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVT 419
Query: 413 DNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGN 472
TS + D ++Q +L L E
Sbjct: 420 AGPTSLDLDVNVQRTLD-----------------------------------NNLATEAY 444
Query: 473 QRRNLESTVSQIEKEKMLLQHRINEYQRKAEQ------ENEKRRNVENEVSTLKDQLEDL 526
+RR + ++E+EK+ L ++ E + + + + + E+ LK+++E L
Sbjct: 445 ERR-----IKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKL 499
Query: 527 KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQ-LESLNREL 585
+K S S L++QLEEAN +R E D A R K++ + K++ Q E LN+EL
Sbjct: 500 RKQVTES-------SHLEQQLEEAN-AVRQELDDAFRQIKAYEKQIKTLQQEREDLNKEL 551
Query: 586 QERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNL 645
+ + L+N + + Q + ++ +E+ Q ++++ + + +
Sbjct: 552 VQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVM 611
Query: 646 EKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSI 705
+KVE R+E L +E+ K LE+ H A K + +
Sbjct: 612 QKVESLRQE----LRRTERAKKELEV-------------------HTEALAAEASKDRKL 648
Query: 706 EEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQ--CSMLDVDLKQSQQKLEHLTGNKE 763
E ++E +L+ ++ + V IE Q + L DL++ E +E
Sbjct: 649 REQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKRE 708
Query: 764 RME-DEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLE 822
+ +E+KNL +L ++L L E+ + + + + ++E + E K+ E
Sbjct: 709 GIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFES--EFKQQYE 766
Query: 823 FELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKEL---KEEIEEKNRENLKKIQ 879
E LT++ + ++ +L E + + +VK+L KE + + + IQ
Sbjct: 767 REKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQ 826
Query: 880 ELQNEKETLATQLDLAETKAES-EQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTV 938
+ +EK+ LA E E L L + ++ + ++ A + + +
Sbjct: 827 WVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSAL 886
Query: 939 SRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTL 998
A + +++ ++ N +TE K E+ LE EI L E+ + +E+ +
Sbjct: 887 DAEIRAKQAIQEELNKVKASN-IITECKLKDSEKKNLELLSEIEQLIKDTEE-LRSEKGI 944
Query: 999 KTQ-AVNKLAEIMNRKDFKIDR--------KKANTQDLRKKEKENRKLQLELNQEREKFN 1049
+ Q + + +N +D+ +T LRKK + K +
Sbjct: 945 EHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPTLRKKGCPGS----TGFPPKRKTH 1000
Query: 1050 QMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIE--QLRAKLLDLSDSTSVASFP 1107
Q VK +C L + L + E + ++ + + P
Sbjct: 1001 QFFVK--------SFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVP 1052
Query: 1108 SADETDGNL---PESRI----EGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKE 1160
++T G L P+ I EG + +P +K+ GW++ +V K+ Y D + +
Sbjct: 1053 -PEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKK-GWQRALAIVCDFKLFLY-DIAEGK 1109
Query: 1161 QSNPSMVLD-----IDKLFHVRPVTQGDVYRAETEEIPKIFQI----LYANEGEC 1206
S PS+V+ D+ F V V DV A ++IP IF++ L A+ +C
Sbjct: 1110 ASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKC 1164
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 449 bits (1155), Expect = e-126
Identities = 299/942 (31%), Positives = 506/942 (53%), Gaps = 111/942 (11%)
Query: 6 SFETRFEKMDNLLRDPKSEVNSDC-----LLDGLDALVYDLDFPALRKNKNIDNFLSRYK 60
S E R +++ + D ++ N C LLD L L + + LR+ KNI +L K
Sbjct: 2 SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAK 61
Query: 61 DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF 120
+K++ +R+ ED+E++KVIGRGAFGEV +V+ K+ KV+AMK+L+K+EM+KR+++A
Sbjct: 62 PFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC 121
Query: 121 FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFY 178
F EERD++ ++ W+ L YAFQDD LY+VM+Y GGDL+ L+S ++ +PE ARFY
Sbjct: 122 FREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFY 181
Query: 179 TAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTP 238
AE+V+A+D++H + ++HRD+KPDN+L+D +GH++LADFG+C+K+ ++G V+ AVGTP
Sbjct: 182 LAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTP 241
Query: 239 DYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSL 297
DYISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIMNHK
Sbjct: 242 DYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERF 301
Query: 298 TFPDD-NDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVV 356
FP D+S+ AK+LI + RE RLG+NG+E+ K+H FF W+ +R+ AP +
Sbjct: 302 QFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID--WDNIRNCEAPYI 359
Query: 357 PDLSSDIDTSNFDDLEEDKGEEETFPIP--KAFVGNQLPFVGFTYYSN--RRYLSSANPN 412
P++SS DTSNFD ++ ET P P AF G+ LPFVGFTY S+ S
Sbjct: 360 PEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVT 419
Query: 413 DNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGN 472
TS + D ++Q +L L E
Sbjct: 420 AGPTSLDLDVNVQRTLD-----------------------------------NNLATEAY 444
Query: 473 QRRNLESTVSQIEKEKMLLQHRINEYQRKAEQ------ENEKRRNVENEVSTLKDQLEDL 526
+RR + ++E+EK+ L ++ E + + + + + E+ LK+++E L
Sbjct: 445 ERR-----IKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKL 499
Query: 527 KKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQ 586
+K S S L++QLEEAN +R E D A R K++ + Q+++L +E +
Sbjct: 500 RKQVTES-------SHLEQQLEEAN-AVRQELDDAFRQIKAYEK------QIKTLQQERE 545
Query: 587 ERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARIT--------SLQEEV 638
+ N++ ++++ + + ++E + ++E+ G Q +I+ Q+E+
Sbjct: 546 DLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEI 605
Query: 639 KHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARL 698
LK +LEK + + E+ I N ++K+L++ L + +
Sbjct: 606 TKLKTDLEK---------KSIFYEEELSKREGIHAN-EIKNLKKELHDSEGQQLALNKEI 655
Query: 699 TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHL 758
+E+ + + E E + E E +++ E V + ++ L +L + E+L
Sbjct: 656 MILKDKLEKTRRESQSERE---EFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENL 712
Query: 759 TGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEAD---NLKGLEKQMKQEINTLL 815
+ + +++E+EVK+L + E ++ + ++ + E D L+ L +M +E+ L
Sbjct: 713 SIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALR 772
Query: 816 EAK-RLLEFELAQLTKQYRGNEGQMR-ELQDQLEAEQYFSTLYKTQVKELK--------- 864
+ ++ +++ + R ELQ L+AE + ++ ++K
Sbjct: 773 NSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECK 832
Query: 865 -EEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLA 905
++ E+KN E L +I++L + E L ++ + ++ LA
Sbjct: 833 LKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLA 874
Score = 71.2 bits (173), Expect = 6e-12
Identities = 139/670 (20%), Positives = 268/670 (40%), Gaps = 73/670 (10%)
Query: 577 QLESLNRELQERNRILENSKSQTDK-DYYQLQAILEAERRDRGHDSEMIGDLQARITSLQ 635
+++ L +E E +R L+ S Y + L A + D E I +L+ I L+
Sbjct: 447 RIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASK-----DLE-IKNLKEEIEKLR 500
Query: 636 EEV---KHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQ--EVNE 690
++V HL+ LE+ R+E D + + ++K+LQQ E ++
Sbjct: 501 KQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEK--------QIKTLQQEREDLNKLEV 552
Query: 691 HKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQ--CSMLDVDL 748
H A K + + E ++E +L+ ++ + V IE Q + L DL
Sbjct: 553 HTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDL 612
Query: 749 KQSQQKLEHLTGNKERME-DEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQM 807
++ E +E + +E+KNL +L ++L L E+ + + + +
Sbjct: 613 EKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSE 672
Query: 808 KQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKEL---K 864
++E + E K+ E E LT++ + ++ +L E + + +VK+L K
Sbjct: 673 REEFES--EFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKK 730
Query: 865 EEIEEKNRENLKKIQELQNEKETLATQLDLAETKAES-EQLARGLLEEQYFELTQESKKA 923
E + + + IQ + +EK+ LA E E L L + ++ + ++
Sbjct: 731 ESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRF 790
Query: 924 ASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISN 983
A + + + A + +++ ++ N +TE K E+ LE EI
Sbjct: 791 AKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNI-ITECKLKDSEKKNLELLSEIEQ 849
Query: 984 LKAAFEKNINTERTLKTQ-AVNKLAEIMNRKDFKIDRKKA--------NTQDLRKKEKEN 1034
L E+ + +E+ ++ Q + + +N +D+ + +T LRKK
Sbjct: 850 LIKDTEE-LRSEKGIEHQDSQHSFLAFLNTPTDALDQFETVDSTPLSVHTPTLRKKGCPG 908
Query: 1035 RKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQ--LRA 1092
+ K +Q VK +C L + L + E
Sbjct: 909 STGF----PPKRKTHQFFVK--------SFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSC 956
Query: 1093 KLLDLSDSTSVASFPSADETDGNL---PESRI----EGWLSVPNRGNIKRYGWKKQYVVV 1145
+ ++ + + P ++T G L P+ I EG + +P +K+ GW++ +V
Sbjct: 957 HITCVNKAPTTCPVPP-EQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKK-GWQRALAIV 1014
Query: 1146 SSKKILFYNDEQDKEQSNPSMVLDI-----DKLFHVRPVTQGDVYRAETEEIPKIFQI-- 1198
K+ Y+ + K S PS+V+ D+ F V V DV A ++IP IF++
Sbjct: 1015 CDFKLFLYDIAEGKA-SQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTA 1073
Query: 1199 --LYANEGEC 1206
L A+ +C
Sbjct: 1074 SQLSASNNKC 1083
Score = 57.8 bits (138), Expect = 7e-08
Identities = 96/462 (20%), Positives = 191/462 (41%), Gaps = 79/462 (17%)
Query: 628 QARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQE 687
+ RI L++E L L+ E + L +S + L + ++K+L++ +E
Sbjct: 445 ERRIKRLEQEKLELSRKLQ----ESTQTVQALQYSTVD-GPLTASKDLEIKNLKEEIE-- 497
Query: 688 VNEHKVTKARLTDKH--QSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLD 745
K+ K H Q +EEA +V R+ + A ++ EKQ L
Sbjct: 498 ----KLRKQVTESSHLEQQLEEANAV------------RQELDDAFRQIKAYEKQIKTL- 540
Query: 746 VDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELK----TQAFEADNLK 801
+Q ++ L L + E + E EQ + L+NEL+ Q + +
Sbjct: 541 ---QQEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVC 597
Query: 802 GLEKQMK-QEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQV 860
+E Q + ++ T LE K + E +L+K+ + +++ L+ +L + ++
Sbjct: 598 SIEHQQEITKLKTDLEKKSIFYEE--ELSKREGIHANEIKNLKKELHDSEGQQLALNKEI 655
Query: 861 KELKEEIEEKNRENLKKIQE---------------LQNEKETLATQLDLAETKAESEQLA 905
LK+++E+ RE+ + +E L E + L ++LD T E+ +
Sbjct: 656 MILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIH 715
Query: 906 RGLLEEQYFELTQESKKAA------SRNRQEITDKDHTVSRLEEANSMLTKDIEILRREN 959
LEE+ +L + + A + Q ++D+ L+ S +T+++E LR +
Sbjct: 716 NQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSS 775
Query: 960 --EELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKI 1017
T+ K KL+ + L++A + I ++ ++ + +
Sbjct: 776 LGTRATDMPWKMRRFAKLDMSARL-ELQSALDAEIRAKQAIQEE---------------L 819
Query: 1018 DRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKEL 1059
++ KA+ K K++ K LEL E E+ ++K +EL
Sbjct: 820 NKVKASNIITECKLKDSEKKNLELLSEIEQ----LIKDTEEL 857
Score = 45.4 bits (106), Expect = 4e-04
Identities = 59/291 (20%), Positives = 114/291 (39%), Gaps = 73/291 (25%)
Query: 840 RELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKE----TLATQLDLA 895
R L + L E Y + + + ++L E+ K +E+ + +Q LQ T + L++
Sbjct: 433 RTLDNNLATEAYERRIKRLEQEKL--ELSRKLQESTQTVQALQYSTVDGPLTASKDLEIK 490
Query: 896 ETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSM-------- 947
K E E+L R+++T+ H +LEEAN++
Sbjct: 491 NLKEEIEKL-----------------------RKQVTESSHLEQQLEEANAVRQELDDAF 527
Query: 948 -----LTKDIEILRRENEELTE----------------KMKKAEEEYKLEKEEEISNLKA 986
K I+ L++E E+L + K+++ E Y + E E+ LK
Sbjct: 528 RQIKAYEKQIKTLQQEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLK- 586
Query: 987 AFEKNINTERTL----KTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRK------ 1036
+K I+ + Q + KL + +K + + + + + E +N K
Sbjct: 587 --QKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDS 644
Query: 1037 --LQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKES 1085
QL LN+E + K ++E + + E + E + L ++E+
Sbjct: 645 EGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEEN 695
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 434 bits (1115), Expect = e-121
Identities = 278/830 (33%), Positives = 467/830 (56%), Gaps = 61/830 (7%)
Query: 28 DCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAF 87
D LLD L AL ++L LR+ +++ FLS ++K+++LR++ +D+E++KVIGRGAF
Sbjct: 23 DGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAF 82
Query: 88 GEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDR 147
GEV +VR + T +++AMK+L K+EM+KR+++A F EERD++ +S WV L YAFQD+
Sbjct: 83 GEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEE 142
Query: 148 YLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNML 205
YLY+VM+Y GGDL+ L+S ++ +P + A+FY AE+VLA+ ++H +G++HRDVKPDN+L
Sbjct: 143 YLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVL 202
Query: 206 LDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS-QGGDGYYGRECDWWSV 264
LD +GH++LADFG+C+++N GMV AVGTPDYISPE+L++ + G G+YG +CDWWS+
Sbjct: 203 LDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSL 262
Query: 265 GVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDD-NDISKEAKNLICAFLTDREVR 323
GV YE+L G+TPFYA+SLV TY KIMNH++ L FP D D+ A++LI L +E R
Sbjct: 263 GVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEER 322
Query: 324 LGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPI 383
LGR G+++ + H FF+ WE L + AP +P+L +DTSNFD ++ T P
Sbjct: 323 LGRGGLDDFRNHPFFEGVD--WERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPP 380
Query: 384 PK--AFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHN 441
P AF G+ LPFVGFTY S S +P +SS A +L+ LQ EQ
Sbjct: 381 PSHGAFSGHHLPFVGFTYTS-----GSHSP---ESSSEAWAALERKLQ-----CLEQEKV 427
Query: 442 EMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRK 501
E+ K + T + +L+++ KE+ + L + ++ ++K L
Sbjct: 428 ELSRKHQEALHAPTDHRELEQLRKEV-------QTLRDRLPEMLRDKASLSQTDGPPAGS 480
Query: 502 AEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTA 561
Q+++ R+ ++ L + L+ Q A + +L ++L+EA + E+ TA
Sbjct: 481 PGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQE---REAATA 537
Query: 562 VRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQ-LQAILEAERRDRGHD 620
+ R +S + + + REL+ + L +Q + Q L+ +A+ +
Sbjct: 538 SQTR----ALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASE 593
Query: 621 SEMIGDLQA--RITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLK 678
+ +G + + L++EV L+ LE+ R ++ +E+N +L
Sbjct: 594 TNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENR-------RLS 646
Query: 679 SLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIE 738
Q+RLE E+ + + +K RL + + E + ++ + +E+ +R + ++
Sbjct: 647 REQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMA 706
Query: 739 KQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEAD 798
++ +S + + T ++ + K LQ + E++ RL LQ+ L+ E
Sbjct: 707 EEL--------ESLRNVGTQTLPARPLDHQWKARRLQ-KMEASARLELQSALEA---EIR 754
Query: 799 NLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEA 848
+GL++++ Q L+A+R L+ + KQ + + ++ L+++L A
Sbjct: 755 AKQGLQERLTQVQEAQLQAERRLQ----EAEKQSQALQQELAMLREELRA 800
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/82 (35%), Positives = 47/82 (57%), Gaps = 7/82 (8%)
Query: 1122 EGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPS----MVLDI-DKLFHV 1176
EG+LSVP ++R GW++ + +S ++L + D D S PS VLD+ D F
Sbjct: 951 EGFLSVPRPSGVRR-GWQRVFAALSDSRLLLF-DAPDLRLSPPSGALLQVLDLRDPQFSA 1008
Query: 1177 RPVTQGDVYRAETEEIPKIFQI 1198
PV DV A++ ++P+IF++
Sbjct: 1009 TPVLASDVIHAQSRDLPRIFRV 1030
Score = 45.4 bits (106), Expect = 4e-04
Identities = 61/308 (19%), Positives = 124/308 (40%), Gaps = 62/308 (20%)
Query: 805 KQMKQEINTLLEAKRLLEF-----ELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQ 859
+Q+++E+ TL + RL E L+Q G+ GQ +L+ +L+ +
Sbjct: 447 EQLRKEVQTLRD--RLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAG 504
Query: 860 VKELKEEI---EEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFEL 916
++ ++E+ + + E L+++QE Q + A+Q ++ E + A+ LE Q L
Sbjct: 505 LQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSL 564
Query: 917 TQESKKAASRNRQEITDKDH--TVSRLEEANSMLTKD----IEILRRENEELTEKMKKAE 970
+++ + + Q + + T+ E N M + LR+E L E++++A
Sbjct: 565 SRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAH 624
Query: 971 EEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKK 1030
KEE + L+ ++ R+
Sbjct: 625 SHRPSGKEEALCQLQ---------------------------------------EENRRL 645
Query: 1031 EKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV-------EECAHRNELQMQLASK 1083
+E +L+ EL QE+E ++ + ++ ++ +AQL +E R LQ
Sbjct: 646 SREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKM 705
Query: 1084 ESDIEQLR 1091
++E LR
Sbjct: 706 AEELESLR 713
Score = 45.1 bits (105), Expect = 5e-04
Identities = 92/434 (21%), Positives = 170/434 (39%), Gaps = 80/434 (18%)
Query: 567 SHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGD 626
SH+ S S +L R+LQ LE K + + + Q L A D +
Sbjct: 402 SHSPESSS-EAWAALERKLQ----CLEQEKVELSRKH---QEALHAPT-----DHRELEQ 448
Query: 627 LQARITSLQEEVKHL---KHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQR 683
L+ + +L++ + + K +L + +G + + +E + L +L LQ +
Sbjct: 449 LRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQ 508
Query: 684 LEQEVNEHKVTKARLTDKHQSIEEAKSVAMCE---MEKKLKEEREAREKAENRVVQIEKQ 740
EQE+ + + L + Q +E ++ + + +L+E R A+ + E +V + +Q
Sbjct: 509 -EQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQ 567
Query: 741 CSMLDVDLKQ-----SQQKLEHLTGN------------KERMEDEVKNLTLQLEQESNKR 783
+ L +Q SQ K H + ++ EV L QLEQ + R
Sbjct: 568 VTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHR 627
Query: 784 LLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQ 843
+ E Q +++E L + LE ELAQ + + EG+ RE +
Sbjct: 628 PSGKEEALCQ-------------LQEENRRLSREQERLEAELAQEQESKQRLEGERRETE 674
Query: 844 DQLEA-----------EQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQL 892
EA E+ + ++ EE+E + + + + A +L
Sbjct: 675 SNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRL 734
Query: 893 DLAETKA--------ESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEA 944
E A E+E A+ L+E+ ++ QE++ A R QE E+
Sbjct: 735 QKMEASARLELQSALEAEIRAKQGLQERLTQV-QEAQLQAERRLQE----------AEKQ 783
Query: 945 NSMLTKDIEILRRE 958
+ L +++ +LR E
Sbjct: 784 SQALQQELAMLREE 797
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 433 bits (1113), Expect = e-121
Identities = 331/1165 (28%), Positives = 588/1165 (50%), Gaps = 145/1165 (12%)
Query: 23 SEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVI 82
S ++ + +LD L L + PAL K K++ NF+ +Y DTI ++++L+ A+D+EV ++
Sbjct: 44 SPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLV 103
Query: 83 GRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYA 142
G G F EVQ+VR K+T +YAMK++ K ++ + +FF EER+I++ + SPW+ QL YA
Sbjct: 104 GCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYA 163
Query: 143 FQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVK 200
FQD +LY+VMEY PGGDL++L++ Y+ + E +FY AE++LA+ ++H MG++HRD+K
Sbjct: 164 FQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIK 223
Query: 201 PDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGD--GYYGRE 258
P+N+L+D++GH+KL DFG+ KMN MV +GTPDY++PEVL GD G YG +
Sbjct: 224 PENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLD 283
Query: 259 CDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLT 318
CDWWSVGV YEM+ G +PF + T++ IMN + L FPDD +S + +LI + L
Sbjct: 284 CDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLC 343
Query: 319 DREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDK--G 376
++ RL G + H FF W +R++ P VP L SD DTSNFD+ E++
Sbjct: 344 GQKERLKFEG---LCCHPFFSKID--WNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVS 398
Query: 377 EEETFPIPKAFVGNQLPFVGFTY------YSNRRYLSSANPNDNRTSSN------ADKSL 424
P F G +LPFVGF+Y + S + +TSS K L
Sbjct: 399 SSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKEL 458
Query: 425 QESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKL-----------DKIMKELDEEGNQ 473
Q+S Q +K+E+++ + E+E ++L + + E +
Sbjct: 459 QDS-QDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSL 517
Query: 474 RRNLEST---VSQIEKEKMLLQHRINEYQRKAEQ--ENEKRRNVENEVSTLKDQLED--- 525
+R+LE VSQ + + + L H I E RK ++ E E + VE E+ + +QLE+
Sbjct: 518 KRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVE-EMRLMMNQLEEDLV 576
Query: 526 --------LKKVSQNSQLANE----KLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSK 573
+ + S+LA E K ++ Q +L +A D + E +L K + E
Sbjct: 577 SARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQL 636
Query: 574 SISQL-ESLNRELQ---ERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMI--GDL 627
I +L E L + ++ E +L+N + ++ +L+ + E G +++ +L
Sbjct: 637 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEEL 696
Query: 628 QARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYK--LKSLQQRLE 685
+ + Q +HL+ +L++ E +E +L+ N ++ DL K L+++ QR E
Sbjct: 697 EEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD------NQIKKDLADKETLENMMQRHE 750
Query: 686 QEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLD 745
+E +E K ++ + +++ A + +E+++ E EA + A N + ++ +
Sbjct: 751 EEAHE----KGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQE 806
Query: 746 ---VDLKQSQQKLEHLTGNKE----RMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEAD 798
+L+Q + LE G E ++E++++ ++ Q + N+ L L+ L+ + E +
Sbjct: 807 EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHE 866
Query: 799 NLKGLEKQMKQEINTLLEAKR-LLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYK 857
K LE KR L E +L+ ++E + QL A Q +
Sbjct: 867 EQK-------------LELKRQLTELQLS------------LQERESQLTALQAARAALE 901
Query: 858 TQVKELKEEIEEKNRENLKKIQELQNEKETLATQLD--------LAETKAESEQLA--RG 907
+Q+++ K E+EE E ++IQ L ++ + + D + + + + QL
Sbjct: 902 SQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNA 961
Query: 908 LLEEQYFELTQESKKAASRN-------------RQEITDKD-------HTVSRLEEANSM 947
L Q F L+++ +A+ N R+EIT+++ T+ L+ +M
Sbjct: 962 ELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 1021
Query: 948 LTKDIEILRRENEELTEKMKKAEEEYKL--EKEEEISNLKAAFEKNINTERTLKTQAVNK 1005
L + + L N+EL EK ++ E + +++ + ++ ++TE+ + +A +
Sbjct: 1022 LEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQR 1081
Query: 1006 LAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQ 1065
+ E + + KA L++ KE + L+ +K N + KH + +M A+
Sbjct: 1082 ITESRQVVELAVKEHKAEILALQQALKEQK---LKAESLSDKLNDLEKKH--AMLEMNAR 1136
Query: 1066 -LVEECAHRNELQMQLASKESDIEQ 1089
L ++ EL+ +L +++ ++Q
Sbjct: 1137 SLQQKLETERELKQRLLEEQAKLQQ 1161
Score = 89.4 bits (220), Expect = 2e-17
Identities = 112/528 (21%), Positives = 235/528 (44%), Gaps = 59/528 (11%)
Query: 414 NRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDE---MEQKCRTSNIKLDKIMKELDEE 470
N+ ++N+ Q +++ + E + L+ + +E + R +L+KI + +
Sbjct: 788 NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSD 847
Query: 471 GNQRRNLESTVSQI----EKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDL 526
N+ LE+ + ++ E++K+ L+ ++ E Q ++ + ++ + L+ QL
Sbjct: 848 KNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 907
Query: 527 K-KVSQNSQLANEKLSQLQKQLEEAN---DLLRTESDTAVRLRKSHTEMSKSISQLESLN 582
K ++ + + A E++ L +E D LR S T + T++ + ++QL N
Sbjct: 908 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRN-SCTVI------TDLEEQLNQLTEDN 960
Query: 583 RELQERNRILE---NSKSQTDKDYYQLQAILEAERRDRGH-------DSEMIGDLQARIT 632
EL +N L + S + + QL++ ++ RR+ + + L+ T
Sbjct: 961 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT 1020
Query: 633 SLQEEVKHLKH-NLEKVEGERK-EAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNE 690
L+E+V L+ N E +E ER+ EA + EK + +++ LQ+ L+ E
Sbjct: 1021 MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQ------FECRVRELQRMLDTEKQS 1074
Query: 691 HKVTKARLTDKHQSIEEAKSVAMCE---MEKKLKEEREAREKAENRVVQIEKQCSMLDVD 747
R+T+ Q +E A E +++ LKE++ E +++ +EK+ +ML+++
Sbjct: 1075 RARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMN 1134
Query: 748 LKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQM 807
+ QQKLE K+R+ +E L Q++ + N L L+ AD LK +
Sbjct: 1135 ARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDL 1194
Query: 808 KQEI---------------NTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYF 852
+ ++ T+ + +L++F A++ + + +G L + + +
Sbjct: 1195 EYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKG----LFSRRKEDPAL 1250
Query: 853 STLYKTQVKELKEEIEEKNRENLKKIQELQNEK-ETLATQLDLAETKA 899
T Q ELK +E++ + + LQ + E + + + A KA
Sbjct: 1251 PTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKA 1298
Score = 73.2 bits (178), Expect = 2e-12
Identities = 104/477 (21%), Positives = 217/477 (45%), Gaps = 67/477 (14%)
Query: 662 SEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLK 721
S + +++E L K K LQ + + HK+ + +T H+ + E ++V + + E +LK
Sbjct: 440 SPAKTSSMEKKLLIKSKELQ---DSQDKCHKMEQ-EMTRLHRRVSEVEAV-LSQKEVELK 494
Query: 722 EEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLE----------HLTGNKERMEDEVKN 771
R E + +CS L L+Q++ ++ H + R E+K
Sbjct: 495 ASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 554
Query: 772 LTLQLEQESNKRLLLQNELKTQAFEADNLKGL-EKQMKQEINTLLEAKRLL---EFELAQ 827
Q + E + L+ N+L+ A L E ++++ E KR + +L +
Sbjct: 555 QEYQAQVEEMR--LMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLK 612
Query: 828 LTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQN---E 884
Q + G+ +L+ ++ AEQ + +++EL+E++E+ + + + + LQN
Sbjct: 613 AKDQGKPEVGEYAKLE-KINAEQ------QLKIQELQEKLEKAVKASTEATELLQNIRQA 665
Query: 885 KETLATQLDLAETKAES-EQLARGLLE-EQYFELTQESKKAASRNRQEITDKD-HTVSRL 941
KE +L+ + + +S E + + L+E E+ E +E++ +A + K+ H ++
Sbjct: 666 KERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKI 725
Query: 942 EEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKA---AFEKNINT--ER 996
+ ++ + KD+ ++E E M + EE EK + +S KA A + I + +R
Sbjct: 726 KVLDNQIKKDLA-----DKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQR 780
Query: 997 TLKTQAVNKLA---EIMNRKDFKIDRKKANTQDLR-----------KKEKENRKLQLELN 1042
++ NKLA + +++ K + + +LR K E +NRKL+ +L
Sbjct: 781 IVELSEANKLAANSSLFTQRNMKAQEEMIS--ELRQQKFYLETQAGKLEAQNRKLEEQLE 838
Query: 1043 Q-------EREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRA 1092
+ ++ + ++ + ++ + + Q +E ELQ+ L +ES + L+A
Sbjct: 839 KISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 895
Score = 40.8 bits (94), Expect = 0.009
Identities = 14/44 (31%), Positives = 25/44 (56%)
Query: 1121 IEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNP 1164
+EGW+ VP + GW ++Y+V+ K+L Y++E + P
Sbjct: 1446 LEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRP 1489
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 365 bits (937), Expect = e-100
Identities = 206/565 (36%), Positives = 325/565 (57%), Gaps = 44/565 (7%)
Query: 6 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINK 65
S E R ++ L+ DP + + LLD L + +L L ++K + +FL + + +
Sbjct: 2 SAEVRLRRLQQLVLDP-GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
Query: 66 IRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEER 125
++++R++ +D+E++KVIGRGAF EV +V+ K T +VYAMK+++K++M+KR + + F EER
Sbjct: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
Query: 126 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVV 183
D++ + W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + ARFY AE+V
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
Query: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISP 243
+A+D++H +G++HRD+KPDN+LLD+ GH++LADFG+C+K+ +G VR AVGTPDY+SP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Query: 244 EVLKSQG---GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 300
E+L++ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+++K L+ P
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
Query: 301 -DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDL 359
D + +EA++ I L E RLGR G + + H FF W+ LRD+V P PD
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDF 358
Query: 360 SSDIDTSNFDDLEEDKGEEETFPIPK--AFVGNQLPFVGFTYYSNRRYLSSANPNDNRTS 417
DT NFD +E+ ET + A +G LPFVG++ YS S P
Sbjct: 359 EGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYS-YSCMALRDSEVPGPTPME 417
Query: 418 SNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNL 477
A++ L+ +Q L+ + + T+ + + + + E
Sbjct: 418 LEAEQLLEPHVQAP------------SLEPSVSPQDETAEVAVPAAVPAAEAEA------ 459
Query: 478 ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLAN 537
E T+ ++ Q E+E R+++ E+ ++ ++ + ++ N
Sbjct: 460 EVTLREL--------------QEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARN 505
Query: 538 EKLSQLQKQLEEANDLLRTESDTAV 562
L +QL+E +LL+ E TAV
Sbjct: 506 RDLEAHVRQLQERMELLQAEGATAV 530
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 365 bits (937), Expect = e-100
Identities = 206/565 (36%), Positives = 325/565 (57%), Gaps = 44/565 (7%)
Query: 6 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINK 65
S E R ++ L+ DP + + LLD L + +L L ++K + +FL + + +
Sbjct: 2 SAEVRLRRLQQLVLDP-GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
Query: 66 IRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEER 125
++++R++ +D+E++KVIGRGAF EV +V+ K T +VYAMK+++K++M+KR + + F EER
Sbjct: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
Query: 126 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVV 183
D++ + W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + ARFY AE+V
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
Query: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISP 243
+A+D++H +G++HRD+KPDN+LLD+ GH++LADFG+C+K+ +G VR AVGTPDY+SP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Query: 244 EVLKSQG---GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 300
E+L++ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+++K L+ P
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
Query: 301 -DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDL 359
D + +EA++ I L E RLGR G + + H FF W+ LRD+V P PD
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDF 358
Query: 360 SSDIDTSNFDDLEEDKGEEETFPIPK--AFVGNQLPFVGFTYYSNRRYLSSANPNDNRTS 417
DT NFD +E+ ET + A +G LPFVG++ YS S P
Sbjct: 359 EGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYS-YSCMALRDSEVPGPTPME 417
Query: 418 SNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNL 477
A++ L+ +Q L+ + + T+ + + + + E
Sbjct: 418 LEAEQLLEPHVQAP------------SLEPSVSPQDETAEVAVPAAVPAAEAEA------ 459
Query: 478 ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLAN 537
E T+ ++ Q E+E R+++ E+ ++ ++ + ++ N
Sbjct: 460 EVTLREL--------------QEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARN 505
Query: 538 EKLSQLQKQLEEANDLLRTESDTAV 562
L +QL+E +LL+ E TAV
Sbjct: 506 RDLEAHVRQLQERMELLQAEGATAV 530
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 362 bits (930), Expect = 1e-99
Identities = 207/570 (36%), Positives = 326/570 (57%), Gaps = 49/570 (8%)
Query: 6 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINK 65
S E R ++ L+ DP + + LLD L + +L L ++K + +FL + + +
Sbjct: 2 SAEVRLRRLQQLVLDP-GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
Query: 66 IRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEER 125
++++R++ +D+E++KVIGRGAF EV +V+ K T +VYAMK+++K++M+KR + + F EER
Sbjct: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
Query: 126 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVV 183
D++ + W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + ARFY AE+V
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
Query: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISP 243
+A+D++H +G++HRD+KPDN+LLD+ GH++LADFG+C+K+ +G VR AVGTPDY+SP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Query: 244 EVLKSQG---GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 300
E+L++ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+++K L+ P
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
Query: 301 -DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDL 359
D + +EA++ I L E RLGR G + + H FF W+ LRD+V P PD
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDF 358
Query: 360 SSDIDTSNFDDLEED-----KGEEETFPIPK--AFVGNQLPFVGFTYYSNRRYLSSANPN 412
DT NFD +E+ G ET + A +G LPFVG++ YS S P
Sbjct: 359 EGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYS-YSCMALRDSEVPG 417
Query: 413 DNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGN 472
A++ L+ +Q L+ + + T+ + + + + E
Sbjct: 418 PTPMELEAEQLLEPHVQAP------------SLEPSVSPQDETAEVAVPAAVPAAEAEA- 464
Query: 473 QRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQN 532
E T+ ++ Q E+E R+++ E+ ++ ++ +
Sbjct: 465 -----EVTLREL--------------QEALEEEVLTRQSLSREMEAIRTDNQNFASQLRE 505
Query: 533 SQLANEKLSQLQKQLEEANDLLRTESDTAV 562
++ N L +QL+E +LL+ E TAV
Sbjct: 506 AEARNRDLEAHVRQLQERMELLQAEGATAV 535
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 348 bits (893), Expect = 2e-95
Identities = 192/511 (37%), Positives = 298/511 (58%), Gaps = 48/511 (9%)
Query: 65 KIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEE 124
+++++R++ +D+E++KVIGRGAF EV +V+ K T +VYAMK+++K++M+KR + + F EE
Sbjct: 70 RLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREE 129
Query: 125 RDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEV 182
RD++ + W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + ARFY AE+
Sbjct: 130 RDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEI 189
Query: 183 VLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYIS 242
V+A+D++H +G++HRD+KPDN+LLD+ GH++LADFG+C+K+ +G VR AVGTPDY+S
Sbjct: 190 VMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLS 249
Query: 243 PEVLKSQG---GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTF 299
PE+L++ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+++K L+
Sbjct: 250 PEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSL 309
Query: 300 P-DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPD 358
P D + +EA++ I L E RLGR G + + H FF W+ LRD+V P PD
Sbjct: 310 PLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPD 367
Query: 359 LSSDIDTSNFDDLEED-----KGEEETFPIPK--AFVGNQLPFVGFTYYSNRRYLSSANP 411
DT NFD +E+ G ET + A +G LPFVG++ YS S P
Sbjct: 368 FEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYS-YSCMALRDSEVP 426
Query: 412 NDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEG 471
A++ L+ +Q L+ + + T+ + + + + E
Sbjct: 427 GPTPMELEAEQLLEPHVQAP------------SLEPSVSPQDETAEVAVPAAVPAAEAEA 474
Query: 472 NQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQ 531
E T+ ++ Q E+E R+++ E+ ++ ++ +
Sbjct: 475 ------EVTLREL--------------QEALEEEVLTRQSLSREMEAIRTDNQNFASQLR 514
Query: 532 NSQLANEKLSQLQKQLEEANDLLRTESDTAV 562
++ N L +QL+E +LL+ E TAV
Sbjct: 515 EAEARNRDLEAHVRQLQERMELLQAEGATAV 545
>gi|239752561 PREDICTED: similar to Rho-associated, coiled-coil
containing protein kinase 1 [Homo sapiens]
Length = 143
Score = 309 bits (791), Expect = 1e-83
Identities = 143/143 (100%), Positives = 143/143 (100%)
Query: 1212 MEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRD 1271
MEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRD
Sbjct: 1 MEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRD 60
Query: 1272 HLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRT 1331
HLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRT
Sbjct: 61 HLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRT 120
Query: 1332 LSTRSTANQSFRKVVKNTSGKTS 1354
LSTRSTANQSFRKVVKNTSGKTS
Sbjct: 121 LSTRSTANQSFRKVVKNTSGKTS 143
>gi|239745983 PREDICTED: similar to Rho-associated, coiled-coil
containing protein kinase 1 [Homo sapiens]
Length = 118
Score = 255 bits (652), Expect = 2e-67
Identities = 115/118 (97%), Positives = 117/118 (99%)
Query: 1212 MEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRD 1271
MEPVQ+AEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALEC+R HVKCHRD
Sbjct: 1 MEPVQEAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECQRRHVKCHRD 60
Query: 1272 HLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASP 1329
HLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASP
Sbjct: 61 HLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASP 118
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 228 bits (581), Expect = 3e-59
Identities = 129/357 (36%), Positives = 201/357 (56%), Gaps = 17/357 (4%)
Query: 20 DPKSEVNSDCLLDGLDALVYDLDFPA-LRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEV 78
D K+ + +D L ++D L K K ++FL ++++ L ED+E
Sbjct: 40 DQKTALENDSLHFSEHTALWDRSMKEFLAKAK--EDFLKKWENPTQNNAGL----EDFER 93
Query: 79 VKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQ 138
K +G G+FG V LV+HK+T + YAMK+L K +++K E+ I+ N P++V+
Sbjct: 94 KKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVR 153
Query: 139 LFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSMGFIHR 197
L YAF+D+ LYMVMEY+PGG++ + + E ARFY A++VL + +HS+ I+R
Sbjct: 154 LEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYR 213
Query: 198 DVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGR 257
D+KP+N+L+D G++++ DFG ++ C GTP+Y++PE++ S+G Y +
Sbjct: 214 DLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLC----GTPEYLAPEIILSKG----YNK 265
Query: 258 ECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFL 317
DWW++GV +YEM G PF+AD + Y KI++ K +D+ +NL+ L
Sbjct: 266 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDL 325
Query: 318 TDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEED 374
T R L +NGV +IK H +F W R AP +P DTSNFDD EE+
Sbjct: 326 TKRFGNL-KNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEE 381
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 228 bits (580), Expect = 4e-59
Identities = 121/323 (37%), Positives = 188/323 (58%), Gaps = 14/323 (4%)
Query: 53 DNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEM 112
++FL ++++ L ED+E K +G G+FG V LV+HK+T + YAMK+L K ++
Sbjct: 25 EDFLKKWENPTQNNAGL----EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKV 80
Query: 113 IKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VP 171
+K E+ I+ N P++V+L YAF+D+ LYMVMEY+PGG++ + +
Sbjct: 81 VKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140
Query: 172 EKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRC 231
E ARFY A++VL + +HS+ I+RD+KP+N+L+D G++++ DFG ++ C
Sbjct: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLC 200
Query: 232 DTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 291
GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y KI+
Sbjct: 201 ----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
Query: 292 NHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDT 351
+ K +D+ +NL+ LT R L +NGV +IK H +F W R
Sbjct: 253 SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVSDIKTHKWFATTDWIAIYQRKV 311
Query: 352 VAPVVPDLSSDIDTSNFDDLEED 374
AP +P DTSNFDD EE+
Sbjct: 312 EAPFIPKFRGSGDTSNFDDYEEE 334
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 223 bits (569), Expect = 7e-58
Identities = 132/341 (38%), Positives = 197/341 (57%), Gaps = 44/341 (12%)
Query: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 134
D++ +K+I GA+G V LVRH+ TR+ +AMK ++K +I R+ + ERDI+ FA +P
Sbjct: 373 DFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 432
Query: 135 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSMG 193
+VV +F +F+ R+L MVMEY+ GGD L+ N +P + AR Y AE VLAL+ +H+ G
Sbjct: 433 FVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYG 492
Query: 194 FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDT------------------AV 235
+HRD+KPDN+L+ GH+KL DFG ++K G++ T
Sbjct: 493 IVHRDLKPDNLLITSMGHIKLTDFG----LSKMGLMSLTTNLYEGHIEKDAREFLDKQVC 548
Query: 236 GTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKN 295
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + ++++ +
Sbjct: 549 GTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS--D 602
Query: 296 SLTFPD-DNDISKEAKNLICAFL-TDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVA 353
+ +P+ D + EA+ LI + L T+ VRLG G E+K+H FF++ W L A
Sbjct: 603 DILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWT--GLLRQKA 660
Query: 354 PVVPDLSSDIDTSNFDDL-----------EEDKGEEETFPI 383
+P L S+ DTS FD E+D EEE I
Sbjct: 661 EFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEI 701
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 223 bits (568), Expect = 1e-57
Identities = 117/324 (36%), Positives = 187/324 (57%), Gaps = 14/324 (4%)
Query: 53 DNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEM 112
++FL +++ L + +E +K +G G+FG V LV+HK T YAMK+L K ++
Sbjct: 17 EDFLKKWESPAQNTAHL----DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKV 72
Query: 113 IKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VP 171
+K E+ I+ N P++V+L ++F+D+ LYMVMEY+PGG++ + +
Sbjct: 73 VKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 132
Query: 172 EKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRC 231
E ARFY A++VL + +HS+ I+RD+KP+N+L+D+ G++++ DFG ++ C
Sbjct: 133 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC 192
Query: 232 DTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 291
GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y KI+
Sbjct: 193 ----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 244
Query: 292 NHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDT 351
+ K +D+ +NL+ LT R L +NGV +IK H +F W R
Sbjct: 245 SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVNDIKNHKWFATTDWIAIYQRKV 303
Query: 352 VAPVVPDLSSDIDTSNFDDLEEDK 375
AP +P DTSNFDD EE++
Sbjct: 304 EAPFIPKFKGPGDTSNFDDYEEEE 327
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 223 bits (568), Expect = 1e-57
Identities = 117/324 (36%), Positives = 187/324 (57%), Gaps = 14/324 (4%)
Query: 53 DNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEM 112
++FL +++ L + +E +K +G G+FG V LV+HK T YAMK+L K ++
Sbjct: 25 EDFLKKWESPAQNTAHL----DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKV 80
Query: 113 IKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VP 171
+K E+ I+ N P++V+L ++F+D+ LYMVMEY+PGG++ + +
Sbjct: 81 VKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140
Query: 172 EKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRC 231
E ARFY A++VL + +HS+ I+RD+KP+N+L+D+ G++++ DFG ++ C
Sbjct: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLC 200
Query: 232 DTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 291
GTP+Y++PE++ S+G Y + DWW++GV +YEM G PF+AD + Y KI+
Sbjct: 201 ----GTPEYLAPEIILSKG----YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
Query: 292 NHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDT 351
+ K +D+ +NL+ LT R L +NGV +IK H +F W R
Sbjct: 253 SGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL-KNGVNDIKNHKWFATTDWIAIYQRKV 311
Query: 352 VAPVVPDLSSDIDTSNFDDLEEDK 375
AP +P DTSNFDD EE++
Sbjct: 312 EAPFIPKFKGPGDTSNFDDYEEEE 335
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 223 bits (567), Expect = 1e-57
Identities = 128/326 (39%), Positives = 189/326 (57%), Gaps = 25/326 (7%)
Query: 72 KAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 131
+ D+E +K+I GA+G V VRHK +R+ +AMK ++K +I R+ + ERDI+ FA
Sbjct: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
Query: 132 NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIH 190
+P+VV ++ +F+ R+L MVMEY+ GGD LM N +P AR Y AE VLAL+ +H
Sbjct: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLH 496
Query: 191 SMGFIHRDVKPDNMLLDKSGHLKLADFGT----CMKMNK---EGMVRCDT-------AVG 236
+ G +HRD+KPDN+L+ GH+KL DFG M M EG + D G
Sbjct: 497 NYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCG 556
Query: 237 TPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNS 296
TP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + ++++ +
Sbjct: 557 TPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS--DE 610
Query: 297 LTFPD-DNDISKEAKNLICAFLTDREV-RLGRNGVEEIKRHLFFKNDQWAWETLRDTVAP 354
+ +P+ D +A++LI L + RLG G E+K+H FF++ W +L A
Sbjct: 611 INWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRS--LDWNSLLRQKAE 668
Query: 355 VVPDLSSDIDTSNFDDLEEDKGEEET 380
+P L S+ DTS FD E ET
Sbjct: 669 FIPQLESEDDTSYFDTRSEKYHHMET 694
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 221 bits (562), Expect = 5e-57
Identities = 117/307 (38%), Positives = 188/307 (61%), Gaps = 16/307 (5%)
Query: 73 AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 132
++ +E ++ +G G+FG V LVRH+ T YAMK+L+K +++K E+ I+ +
Sbjct: 41 SDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAID 100
Query: 133 SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHS 191
P++V+L ++F+D+ YLY+VMEY+PGG++ + + E A FY A+VVLA+ +HS
Sbjct: 101 FPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHS 160
Query: 192 MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGG 251
+ IHRD+KP+N+L+D+ G+L++ DFG ++ C GTP+Y++PE++ S+G
Sbjct: 161 LDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLC----GTPEYLAPEIILSKG- 215
Query: 252 DGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKN 311
Y + DWW++GV +YEM VG PFYAD + Y KI++ + + FP + +S + K+
Sbjct: 216 ---YNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGR--VRFP--SKLSSDLKH 268
Query: 312 LICAFL-TDREVRLG--RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNF 368
L+ + L D R G RNGV +IK H +F W + AP +P + D SNF
Sbjct: 269 LLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNF 328
Query: 369 DDLEEDK 375
DD EE++
Sbjct: 329 DDYEEEE 335
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 219 bits (557), Expect = 2e-56
Identities = 128/316 (40%), Positives = 186/316 (58%), Gaps = 25/316 (7%)
Query: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 134
D+E +K+I GA+G V LVRH+ TR+ +A+K ++K +I R+ + ERDI+ FA +P
Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
Query: 135 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDAIHSMG 193
+VV +F +F+ R+L MVMEY+ GGD L+ N +P AR Y AE VLAL+ +H+ G
Sbjct: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYG 485
Query: 194 FIHRDVKPDNMLLDKSGHLKLADFG------TCMKMN-KEGMVRCDT-------AVGTPD 239
+HRD+KPDN+L+ GH+KL DFG M N EG + D GTP+
Sbjct: 486 IVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPE 545
Query: 240 YISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTF 299
YI+PEV+ QG YG+ DWW++GV LYE LVG PF+ D+ + ++++ + + +
Sbjct: 546 YIAPEVIFRQG----YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS--DEIMW 599
Query: 300 PD-DNDISKEAKNLICAFLTDREV-RLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVP 357
P+ D + +A++LI L + RLG G E+K+H FF WA L A VP
Sbjct: 600 PEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWA--GLLRHKAEFVP 657
Query: 358 DLSSDIDTSNFDDLEE 373
L ++ DTS FD E
Sbjct: 658 QLEAEDDTSYFDTRSE 673
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 218 bits (556), Expect = 2e-56
Identities = 125/321 (38%), Positives = 184/321 (57%), Gaps = 33/321 (10%)
Query: 74 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 133
ED+E +K+I GA+G V LVRHKSTR+ +AMK ++K +I R+ + ERDI+ FA +
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
Query: 134 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSM 192
P+VV +F +F R+L MVMEY+ GGD L+ N +P R Y AE VLAL+ +H+
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 629
Query: 193 GFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDT------------------A 234
G +HRD+KPDN+L+ GH+KL DFG ++K G++ T
Sbjct: 630 GIVHRDLKPDNLLITSMGHIKLTDFG----LSKIGLMSLTTNLYEGHIEKDAREFLDKQV 685
Query: 235 VGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHK 294
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + ++++
Sbjct: 686 CGTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS-- 739
Query: 295 NSLTFPD-DNDISKEAKNLICAFLTDREV-RLGRNGVEEIKRHLFFKNDQWAWETLRDTV 352
+ + +P+ D + +A++L L + RLG E+K+H FF W L
Sbjct: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWT--GLLRQK 797
Query: 353 APVVPDLSSDIDTSNFDDLEE 373
A +P L S+ DTS FD E
Sbjct: 798 AEFIPQLESEDDTSYFDTRSE 818
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 218 bits (554), Expect = 4e-56
Identities = 113/316 (35%), Positives = 191/316 (60%), Gaps = 17/316 (5%)
Query: 74 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 133
+D++ + +G G FG V LV+ K+ + +A+K++S ++I+ E+ ++ +
Sbjct: 47 QDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSH 106
Query: 134 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSM 192
P++++LF+ + D+R+LYM+MEY+PGG+L + + N FY+AE++ A++ +HS
Sbjct: 107 PFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSK 166
Query: 193 GFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGD 252
++RD+KP+N+LLD+ GH+KL DFG K+ + R T GTP+Y++PEV++S+G
Sbjct: 167 EIVYRDLKPENILLDRDGHIKLTDFGFAKKL----VDRTWTLCGTPEYLAPEVIQSKG-- 220
Query: 253 GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNL 312
+GR DWW++G+ ++EML G PF+ D+ G Y KI+ K + FP D K+L
Sbjct: 221 --HGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGK--IDFPRHLDF--HVKDL 274
Query: 313 ICAFL-TDREVRLG--RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFD 369
I L DR RLG +NG ++K H +F++ W R P+VP ++ D DTSNF+
Sbjct: 275 IKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE 334
Query: 370 DLEEDKGEEETFPIPK 385
E+ + P+P+
Sbjct: 335 TYPENDWDTAA-PVPQ 349
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 204 bits (518), Expect = 6e-52
Identities = 132/343 (38%), Positives = 194/343 (56%), Gaps = 24/343 (6%)
Query: 70 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 129
R+ +++E ++V+G+G+FG+V L R K T +YA+K+L K +++ D E+ I++
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
Query: 130 FA-NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVPEKWARFYTAEVVLALD 187
A N P++ QLF FQ L+ VME++ GGDL+ ++ + E ARFY AE++ AL
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468
Query: 188 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGM---VRCDTAVGTPDYISPE 244
+H G I+RD+K DN+LLD GH KLADFG C KEG+ V T GTPDYI+PE
Sbjct: 469 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMC----KEGICNGVTTATFCGTPDYIAPE 524
Query: 245 VLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDND 304
+L+ YG DWW++GV LYEML G PF A++ + I+N + + +P
Sbjct: 525 ILQEM----LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN--DEVVYP--TW 576
Query: 305 ISKEAKNLICAFLT-DREVRLG---RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS 360
+ ++A ++ +F+T + +RLG + G I RH FFK WA R P P +
Sbjct: 577 LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIK 636
Query: 361 SDIDTSNFDDLEEDKGEEETFPIPKAFVG--NQLPFVGFTYYS 401
S D SNFD + K E PI + + NQ F F+Y S
Sbjct: 637 SREDVSNFDP-DFIKEEPVLTPIDEGHLPMINQDEFRNFSYVS 678
Score = 33.5 bits (75), Expect = 1.4
Identities = 17/58 (29%), Positives = 26/58 (44%), Gaps = 5/58 (8%)
Query: 1216 QQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRC----HVKCH 1269
Q+A + GH+F+ T P C C + +W VF +C+ C H +CH
Sbjct: 159 QRAMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVF-GKQGYQCQVCTCVVHKRCH 215
Score = 30.8 bits (68), Expect = 9.2
Identities = 18/67 (26%), Positives = 31/67 (46%), Gaps = 7/67 (10%)
Query: 1206 CRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRC- 1264
C+ ++ + AE+ F + H+F Y P CD C LW + + L+C+ C
Sbjct: 224 CQNNINKVDSKIAEQ-RFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMR--QGLQCKICK 280
Query: 1265 ---HVKC 1268
H++C
Sbjct: 281 MNVHIRC 287
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 201 bits (510), Expect = 5e-51
Identities = 129/343 (37%), Positives = 194/343 (56%), Gaps = 25/343 (7%)
Query: 70 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 129
R+ +++ +KV+G+G+FG+V L K +VYA+K+L K +++ D E+ I+A
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461
Query: 130 FANS-PWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVPEKWARFYTAEVVLALD 187
A P++ QL+ FQ L+ VMEY+ GGDL+ + + E +RFY AEV AL
Sbjct: 462 LARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALM 521
Query: 188 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGM---VRCDTAVGTPDYISPE 244
+H G I+RD+K DN+LLD GH KLADFG C KEG+ V T GTPDYI+PE
Sbjct: 522 FLHQHGVIYRDLKLDNILLDAEGHCKLADFGMC----KEGILNGVTTTTFCGTPDYIAPE 577
Query: 245 VLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDND 304
+L+ + YG DWW++GV +YEM+ G PF AD+ + I++ + + +P
Sbjct: 578 ILQ----ELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILH--DDVLYP--VW 629
Query: 305 ISKEAKNLICAFLT-DREVRLG----RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDL 359
+SKEA +++ AF+T + RLG +NG + IK+H FFK W + P P +
Sbjct: 630 LSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRI 689
Query: 360 SSDIDTSNFDDLEEDKGEEETFPIPKAFVG--NQLPFVGFTYY 400
+ D +NFD + + E + +A V NQ F GF+Y+
Sbjct: 690 KTKRDVNNFDQ-DFTREEPVLTLVDEAIVKQINQEEFKGFSYF 731
Score = 33.5 bits (75), Expect = 1.4
Identities = 18/66 (27%), Positives = 27/66 (40%), Gaps = 2/66 (3%)
Query: 1205 ECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRC 1264
+C + E Q F + H+F Y P CD C LW + + L+C+ C
Sbjct: 219 KCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLR--QGLQCKVC 276
Query: 1265 HVKCHR 1270
+ HR
Sbjct: 277 KMNVHR 282
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 201 bits (510), Expect = 5e-51
Identities = 130/353 (36%), Positives = 188/353 (53%), Gaps = 20/353 (5%)
Query: 54 NFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMI 113
N +S++ + N RD RMK D+ + V+G+G+FG+V L K T ++YA+K+L K +I
Sbjct: 323 NTVSKFDNNGN--RD-RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVI 379
Query: 114 KRSDSAFFWEERDIMAFANSP-WVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMSNYDVP 171
+ D E+ ++A P ++ QL FQ LY VMEY+ GGDL+ ++
Sbjct: 380 QDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFK 439
Query: 172 EKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRC 231
E A FY AE+ + L + S G I+RD+K DN++LD GH+K+ADFG C + +G V
Sbjct: 440 EPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG-VTT 498
Query: 232 DTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 291
T GTPDYI+PE++ Q YG+ DWW+ GV LYEML G PF + + IM
Sbjct: 499 KTFCGTPDYIAPEIIAYQP----YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 554
Query: 292 NHKNSLTFPDDNDISKEAKNLICAFLT---DREVRLGRNGVEEIKRHLFFKNDQWAWETL 348
H ++ +P +SKEA + +T + + G G +IK H FF+ W
Sbjct: 555 EH--NVAYP--KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLER 610
Query: 349 RDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGN--QLPFVGFTY 399
++ P P DTSNFD E + E P K F+ N Q F GF+Y
Sbjct: 611 KEIQPPYKPKARDKRDTSNFDK-EFTRQPVELTPTDKLFIMNLDQNEFAGFSY 662
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 200 bits (509), Expect = 7e-51
Identities = 115/314 (36%), Positives = 178/314 (56%), Gaps = 17/314 (5%)
Query: 71 MKAEDYEVVKVIGRGAFGEVQLVRHKSTR-KVYAMKLLSKFEMIKRSDSAFFWEERDIMA 129
+K D+ ++ +G G FG V+LV+ KS K +AMK+L K ++ E+ IM
Sbjct: 355 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 414
Query: 130 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDA 188
A+S ++V+L+ F+D +YLYM+ME GG+L ++ + + RFYTA VV A
Sbjct: 415 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 474
Query: 189 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKM--NKEGMVRCDTAVGTPDYISPEVL 246
+HS G I+RD+KP+N++LD G+ KL DFG K+ K+ C GTP+Y++PE++
Sbjct: 475 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFC----GTPEYVAPEII 530
Query: 247 KSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDIS 306
++G D D+WS+G+ +YE+L G PF + TY+ I+ + + FP I+
Sbjct: 531 LNKGHD----ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP--KKIA 584
Query: 307 KEAKNLICAFLTDR-EVRLG--RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDI 363
K A NLI D RLG +NGV++I++H +F+ W P++P ++S
Sbjct: 585 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPT 644
Query: 364 DTSNFDDLEEDKGE 377
DTSNFD ED E
Sbjct: 645 DTSNFDSFPEDNDE 658
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 200 bits (509), Expect = 7e-51
Identities = 115/314 (36%), Positives = 178/314 (56%), Gaps = 17/314 (5%)
Query: 71 MKAEDYEVVKVIGRGAFGEVQLVRHKSTR-KVYAMKLLSKFEMIKRSDSAFFWEERDIMA 129
+K D+ ++ +G G FG V+LV+ KS K +AMK+L K ++ E+ IM
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 429
Query: 130 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-DVPEKWARFYTAEVVLALDA 188
A+S ++V+L+ F+D +YLYM+ME GG+L ++ + + RFYTA VV A
Sbjct: 430 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 489
Query: 189 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKM--NKEGMVRCDTAVGTPDYISPEVL 246
+HS G I+RD+KP+N++LD G+ KL DFG K+ K+ C GTP+Y++PE++
Sbjct: 490 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFC----GTPEYVAPEII 545
Query: 247 KSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDIS 306
++G D D+WS+G+ +YE+L G PF + TY+ I+ + + FP I+
Sbjct: 546 LNKGHD----ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP--KKIA 599
Query: 307 KEAKNLICAFLTDR-EVRLG--RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDI 363
K A NLI D RLG +NGV++I++H +F+ W P++P ++S
Sbjct: 600 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPT 659
Query: 364 DTSNFDDLEEDKGE 377
DTSNFD ED E
Sbjct: 660 DTSNFDSFPEDNDE 673
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 198 bits (504), Expect = 3e-50
Identities = 115/305 (37%), Positives = 174/305 (57%), Gaps = 13/305 (4%)
Query: 70 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 129
++ D++ +K++G+G FG+V LVR K+T + YAMK+L K +I + + A E ++
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
Query: 130 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEVVLALDA 188
P++ L YAFQ L VMEY GG+L +S V E+ ARFY AE+V AL+
Sbjct: 206 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 265
Query: 189 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS 248
+HS ++RD+K +N++LDK GH+K+ DFG C + +G T GTP+Y++PEVL+
Sbjct: 266 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG-ATMKTFCGTPEYLAPEVLE- 323
Query: 249 QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKE 308
D YGR DWW +GV +YEM+ G PFY + I+ + FP +S E
Sbjct: 324 ---DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL--MEEIRFP--RTLSPE 376
Query: 309 AKNLICAFL-TDREVRL--GRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDT 365
AK+L+ L D + RL G + +E+ H FF + W + + P P ++S++DT
Sbjct: 377 AKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDT 436
Query: 366 SNFDD 370
FDD
Sbjct: 437 RYFDD 441
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 197 bits (502), Expect = 4e-50
Identities = 118/324 (36%), Positives = 181/324 (55%), Gaps = 17/324 (5%)
Query: 52 IDNFLSRYKDTINKIR---DLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLS 108
+D + +NK R +++K ED+ + K++G+G+FG+V L K T + +A+K L
Sbjct: 353 VDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALK 412
Query: 109 KFEMIKRSDSAFFWEERDIMAFA-NSPWVVQLFYAFQDDRYLYMVMEYMPGGDLV-NLMS 166
K ++ D E+ +++ A P++ +F FQ L+ VMEY+ GGDL+ ++ S
Sbjct: 413 KDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQS 472
Query: 167 NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKE 226
+ A FY AE++L L +HS G ++RD+K DN+LLDK GH+K+ADFG C K N
Sbjct: 473 CHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMC-KENML 531
Query: 227 GMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGT 286
G + +T GTPDYI+PE+L Q Y DWWS GV LYEML+G +PF+
Sbjct: 532 GDAKTNTFCGTPDYIAPEILLGQ----KYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
Query: 287 YSKIMNHKNSLTFPDDNDISKEAKNLIC-AFLTDREVRLGRNGVEEIKRHLFFKNDQWAW 345
+ I ++ +P + KEAK+L+ F+ + E RLG G +I++H F+ W
Sbjct: 588 FHSI--RMDNPFYP--RWLEKEAKDLLVKLFVREPEKRLGVRG--DIRQHPLFREINWEE 641
Query: 346 ETLRDTVAPVVPDLSSDIDTSNFD 369
++ P P + S D SNFD
Sbjct: 642 LERKEIDPPFRPKVKSPFDCSNFD 665
Score = 35.8 bits (81), Expect = 0.29
Identities = 16/49 (32%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
Query: 1227 KGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDK 1275
K HEF T + P C C + +W + K +CR+C+ H+ +DK
Sbjct: 158 KCHEFTATFFPQPTFCSVCHEFVWGLNKQ--GYQCRQCNAAIHKKCIDK 204
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.357
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,590,284
Number of Sequences: 37866
Number of extensions: 2251113
Number of successful extensions: 37186
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1165
Number of HSP's successfully gapped in prelim test: 1694
Number of HSP's that attempted gapping in prelim test: 10048
Number of HSP's gapped (non-prelim): 11068
length of query: 1354
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1240
effective length of database: 13,930,794
effective search space: 17274184560
effective search space used: 17274184560
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.