Guide to the Human Genome
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Search of human proteins with 4885261

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885261 growth differentiation factor 9 precursor [Homo
sapiens]
         (454 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]   937   0.0  
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]     164   1e-40
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...    88   2e-17
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...    86   7e-17
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...    85   1e-16
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...    84   3e-16
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]       84   3e-16
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...    84   3e-16
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...    83   4e-16
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...    82   1e-15
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...    80   4e-15
gi|222352098 nodal precursor [Homo sapiens]                            78   1e-14
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...    78   1e-14
gi|110349792 growth differentiation factor 1 [Homo sapiens]            78   2e-14
gi|7705308 growth differentiation factor 2 [Homo sapiens]              77   4e-14
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...    75   9e-14
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...    75   2e-13
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]              74   4e-13
gi|153792495 growth differentiation factor 15 [Homo sapiens]           69   7e-12
gi|239757187 PREDICTED: similar to growth differentiation factor...    69   7e-12
gi|4504699 inhibin beta A precursor [Homo sapiens]                     68   1e-11
gi|13899338 activin beta E [Homo sapiens]                              65   2e-10
gi|4826740 growth differentiation factor 10 precursor [Homo sapi...    63   5e-10
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       61   2e-09
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           58   2e-08
gi|4885259 myostatin [Homo sapiens]                                    57   3e-08
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    57   5e-08
gi|4504697 inhibin alpha subunit precursor [Homo sapiens]              46   8e-05

>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
          Length = 454

 Score =  937 bits (2423), Expect = 0.0
 Identities = 454/454 (100%), Positives = 454/454 (100%)

Query: 1   MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAG 60
           MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAG
Sbjct: 1   MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAG 60

Query: 61  LLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPC 120
           LLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPC
Sbjct: 61  LLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPC 120

Query: 121 TRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMI 180
           TRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMI
Sbjct: 121 TRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMI 180

Query: 181 KEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCM 240
           KEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCM
Sbjct: 181 KEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCM 240

Query: 241 KDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAY 300
           KDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAY
Sbjct: 241 KDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAY 300

Query: 301 PVGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRL 360
           PVGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRL
Sbjct: 301 PVGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRL 360

Query: 361 SFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCV 420
           SFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCV
Sbjct: 361 SFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCV 420

Query: 421 PAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
           PAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR
Sbjct: 421 PAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score =  164 bits (416), Expect = 1e-40
 Identities = 138/439 (31%), Positives = 190/439 (43%), Gaps = 83/439 (18%)

Query: 27  ASGGEAQIAASAELESGAMPWSLLQHIDERDRAGLLPALFKVLSVGRGGSPRLQPD--SR 84
           A GG++ IA  AE                   A  LP + ++L    G  PR +P     
Sbjct: 26  AEGGQSSIALLAE-------------------APTLPLIEELLEESPGEQPR-KPRLLGH 65

Query: 85  ALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPCTR----HKQAPGDQVTGI-LPSVE 139
           +L YM +LY+  A   G P+ NR+     VRL  P T     H+     Q+ G  L    
Sbjct: 66  SLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTSVARPHRGTWHIQILGFPLRPNR 125

Query: 140 LLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTF 199
            L+ L R T V      +  +N++  V               EP          P S   
Sbjct: 126 GLYQLVRATVVYRHHLQLTRFNLSCHV---------------EPWVQKNPTNHFPSSEGD 170

Query: 200 NSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLV 259
           +S+      + W ++D+T L+Q    +NK    + + F C + Q +    +      +L 
Sbjct: 171 SSKPSL-MSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQ-QKDSGGLELWHGTSSLD 228

Query: 260 SPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRR 319
              L+LY NDT                        R     P G E   + R S  R  R
Sbjct: 229 IAFLLLYFNDTHKSI--------------------RKAKFLPRGMEEFME-RESLLRRTR 267

Query: 320 GQETVSSEL----KKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPH 375
             + +S+E+     K  GP +              N+C LH F++SF QL WD+WI+AP 
Sbjct: 268 QADGISAEVTASSSKHSGPEN--------------NQCSLHPFQISFRQLGWDHWIIAPP 313

Query: 376 RYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPD 435
            Y P YCKG C R +     SP H ++QN+I + +D SVPRPSCVP KY P+SVL IE +
Sbjct: 314 FYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEAN 373

Query: 436 GSIAYKEYEDMIATKCTCR 454
           GSI YKEYE MIA  CTCR
Sbjct: 374 GSILYKEYEGMIAESCTCR 392


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 44/157 (28%), Positives = 74/157 (47%), Gaps = 10/157 (6%)

Query: 300 YPVGEEAAEDGRSSHHRHR---RGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELH 356
           + V E      RS+  R R   R + T S ++ +    + +N SE        +  C  H
Sbjct: 363 FKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSEL-------KTACRKH 415

Query: 357 DFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPR 416
           +  +SF  L W +WI+AP  Y   YC G+C   +     +  H +VQ +++      VP+
Sbjct: 416 ELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPK 475

Query: 417 PSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
           P C P K + +SVL  + + ++  K+Y +M+   C C
Sbjct: 476 PCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 35/105 (33%), Positives = 61/105 (58%), Gaps = 1/105 (0%)

Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
           ++ C+ H   + FS + W++WIVAP  Y+  YC G+CP  +     S  H +VQ ++   
Sbjct: 293 KSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLV-NS 351

Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
           ++S +P+  CVP + S +S+L ++ +  +  K Y+DM+   C CR
Sbjct: 352 VNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 1/102 (0%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
           C  H   + FS + W++WIVAP  Y   YC GDCP  +     S  H +VQ ++   ++S
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLV-NSVNS 366

Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
           S+P+  CVP + S +S+L ++    +  K Y++M+   C CR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 1/102 (0%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
           C  H   + FS + W++WIVAP  Y   YC GDCP  +     S  H +VQ ++   ++S
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLV-NSVNS 366

Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
           S+P+  CVP + S +S+L ++    +  K Y++M+   C CR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 1/102 (0%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
           C  H   + FS + W++WIVAP  Y   YC GDCP  +     S  H +VQ ++   ++S
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLV-NSVNS 366

Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
           S+P+  CVP + S +S+L ++    +  K Y++M+   C CR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 34/105 (32%), Positives = 56/105 (53%)

Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
           ++ C      + F +L WD+WI+AP  Y   +C+G C   +        H ++Q ++   
Sbjct: 346 RSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSM 405

Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
              + P   CVPA+ SP+S+L I+   ++ YK+YEDM+   C CR
Sbjct: 406 APDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 450


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 54/268 (20%), Positives = 106/268 (39%), Gaps = 43/268 (16%)

Query: 190 LGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSA 249
           LGR    F  +S+  +  +  W+  D+T+     V + + ++ + ++   +  Q  +P  
Sbjct: 202 LGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKL 261

Query: 250 QN--GLFNMTLVSPSLILYLNDTSA--QAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEE 305
               G        P ++ +   T    ++  S  S    +  S+ P  + +L    V E 
Sbjct: 262 AGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAEN 321

Query: 306 AAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQL 365
           ++ D R +                                       C+ H+  +SF  L
Sbjct: 322 SSSDQRQA---------------------------------------CKKHELYVSFRDL 342

Query: 366 KWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYS 425
            W +WI+AP  Y   YC+G+C   +     +  H +VQ +++     +VP+P C P + +
Sbjct: 343 GWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLN 402

Query: 426 PLSVLTIEPDGSIAYKEYEDMIATKCTC 453
            +SVL  +   ++  K+Y +M+   C C
Sbjct: 403 AISVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 43/169 (25%), Positives = 78/169 (46%), Gaps = 11/169 (6%)

Query: 289 QGPDQERS--LSAYPVGEEAAEDGRSSHHRHRRGQETVSS--ELKKPLGPASFNLSEYFR 344
           QGP  ++   ++ +   E      R+++ R  + +   SS  +  +      +N SE   
Sbjct: 292 QGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQ-- 349

Query: 345 QFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQN 404
                +  C+ H+  +SF  L W +WI+AP  Y   YC G+C   +     +  H +VQ 
Sbjct: 350 -----KQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQT 404

Query: 405 IIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
           +++      VP+P C P K + +SVL  +   ++  K+Y +M+   C C
Sbjct: 405 LVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 34/102 (33%), Positives = 54/102 (52%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
           C      ++F +L WD+WI+AP  Y   +C+G C   +        H ++Q ++      
Sbjct: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413

Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
           S P   CVP K +P+S+L I+   ++ YK+YEDM+   C CR
Sbjct: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 101/459 (22%), Positives = 173/459 (37%), Gaps = 101/459 (22%)

Query: 70  SVGRGGSPRLQPDSRALHYMKKLYKTYATK---------EGIPKSNRSHLY---NTVRLF 117
           + G G    LQP  +   +M +LY  Y+T          EG  +  R  L    NTVR F
Sbjct: 41  TAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSF 100

Query: 118 TPCTRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINN--SVSFSSAVKCV 175
               R   A   +  G+      +FNL  +T  E++L + L + I    ++S S  V   
Sbjct: 101 ----RAAAAETLERKGLY-----IFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGG 151

Query: 176 CN--------------LMIKEPKSSSRTLGRAPYSFTFNSQFEFGKKHK----WIQIDVT 217
           C+                +K  ++ S+ LG            +  K H+    W+  D+T
Sbjct: 152 CSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHL--------SVDMAKSHRDIMSWLSKDIT 203

Query: 218 SLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLILYLND-------- 269
            LL+   A       +  N T    QL           +    P +++Y ND        
Sbjct: 204 QLLRK--AKENEEFLIGFNITSKGRQLPKR-------RLPFPEPYILVYANDAAISEPES 254

Query: 270 --TSAQAYHSW---------------YSLHYKRRPSQG---PDQERSLSAYPVG---EEA 306
             +S Q + ++                S+  +++ S G   P Q   L         +E 
Sbjct: 255 VVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEV 314

Query: 307 AEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYF----------RQFLLPQNECELH 356
            E+ +       +  E   ++ K+  GP   + +  F          +Q++ P+N C   
Sbjct: 315 WEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRN-CARR 373

Query: 357 DFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK-LDSSVP 415
             ++ F+ + W  WI++P  ++  YC G C   +        H  +Q+I+    +   +P
Sbjct: 374 YLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIP 433

Query: 416 RPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
            P CVP K S LS+L  + + ++  K Y +M    C CR
Sbjct: 434 EPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 33/102 (32%), Positives = 53/102 (51%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
           C      ++F  + WD+WI+AP  Y   +C+G C   +        H ++Q ++      
Sbjct: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPE 459

Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
           S P   CVP + SP+S+L I+   ++ YK+YEDM+   C CR
Sbjct: 460 STPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 3/123 (2%)

Query: 333 GPASFNLSEYFRQFLLPQNE--CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAV 390
           G  S+   +  R+  LP     C    F++ F+ + W +WI+ P +YN   C+G+CP  V
Sbjct: 225 GQLSWEWGKRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPV 284

Query: 391 GHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATK 450
           G  +    H  +Q+++       VP   C P K  PLS+L ++ +G +    ++DMI  +
Sbjct: 285 GEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVD-NGRVLLDHHKDMIVEE 343

Query: 451 CTC 453
           C C
Sbjct: 344 CGC 346


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 32/104 (30%), Positives = 58/104 (55%), Gaps = 1/104 (0%)

Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
           +N C  H   ++F  L W  WI+AP  +   YC G+CP ++     S  +  +Q +++  
Sbjct: 261 KNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMH-A 319

Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
           +D  +P+  C+P K SP+S+L  + + ++  + YEDM+  +C C
Sbjct: 320 VDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 4/110 (3%)

Query: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDC--PRAVGHRYGSPV--HTMVQN 404
           P   C      +SF ++ W  W++AP  +   YC+G C  P A+    G P   H +++ 
Sbjct: 263 PGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRA 322

Query: 405 IIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
           +++     +   P CVPA+ SP+SVL  +   ++  ++YEDM+  +C CR
Sbjct: 323 LMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 54/195 (27%), Positives = 80/195 (41%), Gaps = 18/195 (9%)

Query: 261 PSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRG 320
           P  +++ ND S+    +   L    R     +QE  L      + + E G SSH     G
Sbjct: 252 PFFVVFSNDHSSGTKETRLEL----REMISHEQESVLKKLSK-DGSTEAGESSHEEDTDG 306

Query: 321 QETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPR 380
                S L +    A               + C+    R++F  + WD+WI+AP  Y   
Sbjct: 307 HVAAGSTLARRKRSAGAG------------SHCQKTSLRVNFEDIGWDSWIIAPKEYEAY 354

Query: 381 YCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAY 440
            CKG C   +        H +VQ +++ K  + V +  CVP K SP+SVL  +  G    
Sbjct: 355 ECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTL 414

Query: 441 K-EYEDMIATKCTCR 454
           K  YE M   +C CR
Sbjct: 415 KYHYEGMSVAECGCR 429


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 79/381 (20%), Positives = 145/381 (38%), Gaps = 54/381 (14%)

Query: 88  YMKKLYKTYAT-KEGIPKSNRSHLYNTVRLFTPCTRHKQAPGDQVTGILPSVELLFNLDR 146
           YM +LY  +AT +  +P +N    +    LF+                L    LLFN+  
Sbjct: 84  YMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNG---------LRKYPLLFNVSI 134

Query: 147 ITTVEHLLKSVLLYNI--NNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTFNSQFE 204
               E ++  + LY +   + + +    + +    + E K  +   G        + +  
Sbjct: 135 PHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNE--GERNMLVLVSGEI- 191

Query: 205 FGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLI 264
           +G   +W   DVT  ++    S   +  + ++     D+ E   A +G   +        
Sbjct: 192 YGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAE--DASSGRLEI-------- 241

Query: 265 LYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRGQETV 324
               DTSAQ  H+   + +    S   +++  L+     E+  E           G ++ 
Sbjct: 242 ----DTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPE-------LDNLGLDSF 290

Query: 325 SSELKKPLGPASFNLSEYFRQFLLPQ----------NECELHDFRLSFSQLKWDNWIVAP 374
           SS      GP    L +     +             N C+     + F ++ WD+WI+AP
Sbjct: 291 SS------GPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAP 344

Query: 375 HRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEP 434
             Y    C+G C   +        H ++Q +++ K      +  CVP K  P+S+L ++ 
Sbjct: 345 PGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLD- 403

Query: 435 DGSIAYK-EYEDMIATKCTCR 454
            G + YK +YE M  ++C CR
Sbjct: 404 KGVVTYKFKYEGMAVSECGCR 424


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 28/101 (27%), Positives = 55/101 (54%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
           C  H+  +SF  L W +W++AP  Y+  YC+G+C   +     +  H ++Q++++  +  
Sbjct: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 360

Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
           +VP+  C P K S  SVL  +   ++  +++ +M+   C C
Sbjct: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 28/101 (27%), Positives = 55/101 (54%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
           C  H+  +SF  L W +W++AP  Y+  YC+G+C   +     +  H ++Q++++    +
Sbjct: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPN 360

Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
           +VP+  C P K S  SVL  +   ++  +++ +M+   C C
Sbjct: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|153792495 growth differentiation factor 15 [Homo sapiens]
          Length = 308

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 4/105 (3%)

Query: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYE 408
           P   C LH  R S   L W +W+++P       C G CP        + +H  ++  ++ 
Sbjct: 207 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP---SQFRAANMHAQIKTSLHR 263

Query: 409 KLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
               +VP P CVPA Y+P+ VL  + D  ++ + Y+D++A  C C
Sbjct: 264 LKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 307


>gi|239757187 PREDICTED: similar to growth differentiation factor 15
           [Homo sapiens]
          Length = 270

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 4/105 (3%)

Query: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYE 408
           P   C LH  R S   L W +W+++P       C G CP        + +H  ++  ++ 
Sbjct: 169 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP---SQFRAANMHAQIKTSLHR 225

Query: 409 KLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
               +VP P CVPA Y+P+ VL  + D  ++ + Y+D++A  C C
Sbjct: 226 LKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 28/169 (16%)

Query: 290 GPDQERSLSAYP-VGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLL 348
           G D+E+  S  P +  +A +     H R RRG E                          
Sbjct: 280 GADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKV--------------------- 318

Query: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYE 408
             N C    F +SF  + W++WI+AP  Y+  YC+G+CP  +    GS +      I + 
Sbjct: 319 --NICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHY 376

Query: 409 KLDSSVP----RPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
           ++    P    +  CVP K  P+S+L  +   +I  K+ ++MI  +C C
Sbjct: 377 RMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 8/106 (7%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSP-VHTMVQNIIYEKLD 411
           C   D  + F +L W +WI+ P  Y   YC G CP    H  GSP +     + ++  L 
Sbjct: 247 CCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCP---PHLAGSPGIAASFHSAVFSLLK 303

Query: 412 SSVPRPS----CVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
           ++ P P+    CVP    PLS+L ++ +G++   +  DM+   C C
Sbjct: 304 ANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349


>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 28/103 (27%), Positives = 50/103 (48%), Gaps = 1/103 (0%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK-LD 411
           C     ++ F+ + W+ WI++P  ++  YC G C   +        H  +Q+I+    + 
Sbjct: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435

Query: 412 SSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
             +P P CVP K + L VL ++ + ++  K Y +M    C CR
Sbjct: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 3/106 (2%)

Query: 351 NECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYG--SPVHTMVQNIIYE 408
           N C    F + F  + W++WI+AP  Y   YC+G CP  +    G  S  HT V N    
Sbjct: 301 NLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRM 360

Query: 409 K-LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
           + L+       C+P K S +S+L  + + +I  ++  +MI  +C C
Sbjct: 361 RGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 4/105 (3%)

Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYG--SPVHTMVQNIIYEKL 410
           C   +F + F ++ W +WI+ P  Y   +C G CP  +    G  +  HT V N++    
Sbjct: 247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANT 306

Query: 411 DSSVP--RPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
            +        CVP    PLS+L  + D +I   +  DM+   C C
Sbjct: 307 AAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 7/104 (6%)

Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
           ++ C  +   + F    WD WI+AP RY   YC G+C      +Y    HT   +++++ 
Sbjct: 278 ESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKY---PHT---HLVHQA 330

Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
                  P C P K SP+++L       I Y +   M+  +C C
Sbjct: 331 NPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 29/104 (27%), Positives = 45/104 (43%), Gaps = 7/104 (6%)

Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
           ++ C  +   + F    WD WI+AP RY   YC G C      +Y    HT   +++ + 
Sbjct: 310 ESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKY---PHT---HLVQQA 362

Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
                  P C P K SP+++L       I Y +   M+  +C C
Sbjct: 363 NPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406


>gi|4504697 inhibin alpha subunit precursor [Homo sapiens]
          Length = 366

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 33/128 (25%), Positives = 49/128 (38%), Gaps = 7/128 (5%)

Query: 331 PLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAV 390
           P  P++  L +   +       C      +SF +L W+ WIV P  +   YC G C   +
Sbjct: 240 PWSPSALRLLQRPPEEPAAHANCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHI 299

Query: 391 GHRYGSPV----HTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDG-SIAYKEYED 445
                 PV     T  Q   Y  L  + P  + +P    PL V T    G S  Y+   +
Sbjct: 300 PPNLSLPVPGAPPTPAQP--YSLLPGAQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPN 357

Query: 446 MIATKCTC 453
           ++   C C
Sbjct: 358 LLTQHCAC 365


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,518,321
Number of Sequences: 37866
Number of extensions: 857391
Number of successful extensions: 1979
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1913
Number of HSP's gapped (non-prelim): 55
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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