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Search of human proteins with 4885261
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885261 growth differentiation factor 9 precursor [Homo
sapiens]
(454 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 937 0.0
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 164 1e-40
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 88 2e-17
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 86 7e-17
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 85 1e-16
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 85 1e-16
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 85 1e-16
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 84 3e-16
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 84 3e-16
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 84 3e-16
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 83 4e-16
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 82 1e-15
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 80 4e-15
gi|222352098 nodal precursor [Homo sapiens] 78 1e-14
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 78 1e-14
gi|110349792 growth differentiation factor 1 [Homo sapiens] 78 2e-14
gi|7705308 growth differentiation factor 2 [Homo sapiens] 77 4e-14
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 75 9e-14
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 75 2e-13
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 74 4e-13
gi|153792495 growth differentiation factor 15 [Homo sapiens] 69 7e-12
gi|239757187 PREDICTED: similar to growth differentiation factor... 69 7e-12
gi|4504699 inhibin beta A precursor [Homo sapiens] 68 1e-11
gi|13899338 activin beta E [Homo sapiens] 65 2e-10
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 63 5e-10
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 61 2e-09
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 58 2e-08
gi|4885259 myostatin [Homo sapiens] 57 3e-08
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 57 5e-08
gi|4504697 inhibin alpha subunit precursor [Homo sapiens] 46 8e-05
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 937 bits (2423), Expect = 0.0
Identities = 454/454 (100%), Positives = 454/454 (100%)
Query: 1 MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAG 60
MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAG
Sbjct: 1 MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAG 60
Query: 61 LLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPC 120
LLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPC
Sbjct: 61 LLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPC 120
Query: 121 TRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMI 180
TRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMI
Sbjct: 121 TRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMI 180
Query: 181 KEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCM 240
KEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCM
Sbjct: 181 KEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCM 240
Query: 241 KDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAY 300
KDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAY
Sbjct: 241 KDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAY 300
Query: 301 PVGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRL 360
PVGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRL
Sbjct: 301 PVGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRL 360
Query: 361 SFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCV 420
SFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCV
Sbjct: 361 SFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCV 420
Query: 421 PAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
PAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR
Sbjct: 421 PAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 164 bits (416), Expect = 1e-40
Identities = 138/439 (31%), Positives = 190/439 (43%), Gaps = 83/439 (18%)
Query: 27 ASGGEAQIAASAELESGAMPWSLLQHIDERDRAGLLPALFKVLSVGRGGSPRLQPD--SR 84
A GG++ IA AE A LP + ++L G PR +P
Sbjct: 26 AEGGQSSIALLAE-------------------APTLPLIEELLEESPGEQPR-KPRLLGH 65
Query: 85 ALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPCTR----HKQAPGDQVTGI-LPSVE 139
+L YM +LY+ A G P+ NR+ VRL P T H+ Q+ G L
Sbjct: 66 SLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTSVARPHRGTWHIQILGFPLRPNR 125
Query: 140 LLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTF 199
L+ L R T V + +N++ V EP P S
Sbjct: 126 GLYQLVRATVVYRHHLQLTRFNLSCHV---------------EPWVQKNPTNHFPSSEGD 170
Query: 200 NSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLV 259
+S+ + W ++D+T L+Q +NK + + F C + Q + + +L
Sbjct: 171 SSKPSL-MSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQ-QKDSGGLELWHGTSSLD 228
Query: 260 SPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRR 319
L+LY NDT R P G E + R S R R
Sbjct: 229 IAFLLLYFNDTHKSI--------------------RKAKFLPRGMEEFME-RESLLRRTR 267
Query: 320 GQETVSSEL----KKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPH 375
+ +S+E+ K GP + N+C LH F++SF QL WD+WI+AP
Sbjct: 268 QADGISAEVTASSSKHSGPEN--------------NQCSLHPFQISFRQLGWDHWIIAPP 313
Query: 376 RYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPD 435
Y P YCKG C R + SP H ++QN+I + +D SVPRPSCVP KY P+SVL IE +
Sbjct: 314 FYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQLVDQSVPRPSCVPYKYVPISVLMIEAN 373
Query: 436 GSIAYKEYEDMIATKCTCR 454
GSI YKEYE MIA CTCR
Sbjct: 374 GSILYKEYEGMIAESCTCR 392
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 87.8 bits (216), Expect = 2e-17
Identities = 44/157 (28%), Positives = 74/157 (47%), Gaps = 10/157 (6%)
Query: 300 YPVGEEAAEDGRSSHHRHR---RGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELH 356
+ V E RS+ R R R + T S ++ + + +N SE + C H
Sbjct: 363 FKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSEL-------KTACRKH 415
Query: 357 DFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPR 416
+ +SF L W +WI+AP Y YC G+C + + H +VQ +++ VP+
Sbjct: 416 ELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPK 475
Query: 417 PSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
P C P K + +SVL + + ++ K+Y +M+ C C
Sbjct: 476 PCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 85.9 bits (211), Expect = 7e-17
Identities = 35/105 (33%), Positives = 61/105 (58%), Gaps = 1/105 (0%)
Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
++ C+ H + FS + W++WIVAP Y+ YC G+CP + S H +VQ ++
Sbjct: 293 KSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLV-NS 351
Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
++S +P+ CVP + S +S+L ++ + + K Y+DM+ C CR
Sbjct: 352 VNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 85.1 bits (209), Expect = 1e-16
Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 1/102 (0%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
C H + FS + W++WIVAP Y YC GDCP + S H +VQ ++ ++S
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLV-NSVNS 366
Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
S+P+ CVP + S +S+L ++ + K Y++M+ C CR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 85.1 bits (209), Expect = 1e-16
Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 1/102 (0%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
C H + FS + W++WIVAP Y YC GDCP + S H +VQ ++ ++S
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLV-NSVNS 366
Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
S+P+ CVP + S +S+L ++ + K Y++M+ C CR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 85.1 bits (209), Expect = 1e-16
Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 1/102 (0%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
C H + FS + W++WIVAP Y YC GDCP + S H +VQ ++ ++S
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLV-NSVNS 366
Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
S+P+ CVP + S +S+L ++ + K Y++M+ C CR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 84.0 bits (206), Expect = 3e-16
Identities = 34/105 (32%), Positives = 56/105 (53%)
Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
++ C + F +L WD+WI+AP Y +C+G C + H ++Q ++
Sbjct: 346 RSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSM 405
Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
+ P CVPA+ SP+S+L I+ ++ YK+YEDM+ C CR
Sbjct: 406 APDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 450
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 83.6 bits (205), Expect = 3e-16
Identities = 54/268 (20%), Positives = 106/268 (39%), Gaps = 43/268 (16%)
Query: 190 LGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSA 249
LGR F +S+ + + W+ D+T+ V + + ++ + ++ + Q +P
Sbjct: 202 LGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKL 261
Query: 250 QN--GLFNMTLVSPSLILYLNDTSA--QAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEE 305
G P ++ + T ++ S S + S+ P + +L V E
Sbjct: 262 AGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAEN 321
Query: 306 AAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQL 365
++ D R + C+ H+ +SF L
Sbjct: 322 SSSDQRQA---------------------------------------CKKHELYVSFRDL 342
Query: 366 KWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYS 425
W +WI+AP Y YC+G+C + + H +VQ +++ +VP+P C P + +
Sbjct: 343 GWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLN 402
Query: 426 PLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+SVL + ++ K+Y +M+ C C
Sbjct: 403 AISVLYFDDSSNVILKKYRNMVVRACGC 430
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 83.6 bits (205), Expect = 3e-16
Identities = 43/169 (25%), Positives = 78/169 (46%), Gaps = 11/169 (6%)
Query: 289 QGPDQERS--LSAYPVGEEAAEDGRSSHHRHRRGQETVSS--ELKKPLGPASFNLSEYFR 344
QGP ++ ++ + E R+++ R + + SS + + +N SE
Sbjct: 292 QGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQ-- 349
Query: 345 QFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQN 404
+ C+ H+ +SF L W +WI+AP Y YC G+C + + H +VQ
Sbjct: 350 -----KQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQT 404
Query: 405 IIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+++ VP+P C P K + +SVL + ++ K+Y +M+ C C
Sbjct: 405 LVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 83.2 bits (204), Expect = 4e-16
Identities = 34/102 (33%), Positives = 54/102 (52%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
C ++F +L WD+WI+AP Y +C+G C + H ++Q ++
Sbjct: 354 CSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPG 413
Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
S P CVP K +P+S+L I+ ++ YK+YEDM+ C CR
Sbjct: 414 STPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 82.0 bits (201), Expect = 1e-15
Identities = 101/459 (22%), Positives = 173/459 (37%), Gaps = 101/459 (22%)
Query: 70 SVGRGGSPRLQPDSRALHYMKKLYKTYATK---------EGIPKSNRSHLY---NTVRLF 117
+ G G LQP + +M +LY Y+T EG + R L NTVR F
Sbjct: 41 TAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSF 100
Query: 118 TPCTRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINN--SVSFSSAVKCV 175
R A + G+ +FNL +T E++L + L + I ++S S V
Sbjct: 101 ----RAAAAETLERKGLY-----IFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGG 151
Query: 176 CN--------------LMIKEPKSSSRTLGRAPYSFTFNSQFEFGKKHK----WIQIDVT 217
C+ +K ++ S+ LG + K H+ W+ D+T
Sbjct: 152 CSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHL--------SVDMAKSHRDIMSWLSKDIT 203
Query: 218 SLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLILYLND-------- 269
LL+ A + N T QL + P +++Y ND
Sbjct: 204 QLLRK--AKENEEFLIGFNITSKGRQLPKR-------RLPFPEPYILVYANDAAISEPES 254
Query: 270 --TSAQAYHSW---------------YSLHYKRRPSQG---PDQERSLSAYPVG---EEA 306
+S Q + ++ S+ +++ S G P Q L +E
Sbjct: 255 VVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEV 314
Query: 307 AEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYF----------RQFLLPQNECELH 356
E+ + + E ++ K+ GP + + F +Q++ P+N C
Sbjct: 315 WEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRN-CARR 373
Query: 357 DFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK-LDSSVP 415
++ F+ + W WI++P ++ YC G C + H +Q+I+ + +P
Sbjct: 374 YLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIP 433
Query: 416 RPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
P CVP K S LS+L + + ++ K Y +M C CR
Sbjct: 434 EPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 80.1 bits (196), Expect = 4e-15
Identities = 33/102 (32%), Positives = 53/102 (51%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
C ++F + WD+WI+AP Y +C+G C + H ++Q ++
Sbjct: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPE 459
Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
S P CVP + SP+S+L I+ ++ YK+YEDM+ C CR
Sbjct: 460 STPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 78.2 bits (191), Expect = 1e-14
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 3/123 (2%)
Query: 333 GPASFNLSEYFRQFLLPQNE--CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAV 390
G S+ + R+ LP C F++ F+ + W +WI+ P +YN C+G+CP V
Sbjct: 225 GQLSWEWGKRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPV 284
Query: 391 GHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATK 450
G + H +Q+++ VP C P K PLS+L ++ +G + ++DMI +
Sbjct: 285 GEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVD-NGRVLLDHHKDMIVEE 343
Query: 451 CTC 453
C C
Sbjct: 344 CGC 346
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 78.2 bits (191), Expect = 1e-14
Identities = 32/104 (30%), Positives = 58/104 (55%), Gaps = 1/104 (0%)
Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
+N C H ++F L W WI+AP + YC G+CP ++ S + +Q +++
Sbjct: 261 KNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMH-A 319
Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+D +P+ C+P K SP+S+L + + ++ + YEDM+ +C C
Sbjct: 320 VDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 77.8 bits (190), Expect = 2e-14
Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDC--PRAVGHRYGSPV--HTMVQN 404
P C +SF ++ W W++AP + YC+G C P A+ G P H +++
Sbjct: 263 PGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRA 322
Query: 405 IIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
+++ + P CVPA+ SP+SVL + ++ ++YEDM+ +C CR
Sbjct: 323 LMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 76.6 bits (187), Expect = 4e-14
Identities = 54/195 (27%), Positives = 80/195 (41%), Gaps = 18/195 (9%)
Query: 261 PSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRG 320
P +++ ND S+ + L R +QE L + + E G SSH G
Sbjct: 252 PFFVVFSNDHSSGTKETRLEL----REMISHEQESVLKKLSK-DGSTEAGESSHEEDTDG 306
Query: 321 QETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPR 380
S L + A + C+ R++F + WD+WI+AP Y
Sbjct: 307 HVAAGSTLARRKRSAGAG------------SHCQKTSLRVNFEDIGWDSWIIAPKEYEAY 354
Query: 381 YCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAY 440
CKG C + H +VQ +++ K + V + CVP K SP+SVL + G
Sbjct: 355 ECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTL 414
Query: 441 K-EYEDMIATKCTCR 454
K YE M +C CR
Sbjct: 415 KYHYEGMSVAECGCR 429
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 75.5 bits (184), Expect = 9e-14
Identities = 79/381 (20%), Positives = 145/381 (38%), Gaps = 54/381 (14%)
Query: 88 YMKKLYKTYAT-KEGIPKSNRSHLYNTVRLFTPCTRHKQAPGDQVTGILPSVELLFNLDR 146
YM +LY +AT + +P +N + LF+ L LLFN+
Sbjct: 84 YMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNG---------LRKYPLLFNVSI 134
Query: 147 ITTVEHLLKSVLLYNI--NNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTFNSQFE 204
E ++ + LY + + + + + + + E K + G + +
Sbjct: 135 PHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNE--GERNMLVLVSGEI- 191
Query: 205 FGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLI 264
+G +W DVT ++ S + + ++ D+ E A +G +
Sbjct: 192 YGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAE--DASSGRLEI-------- 241
Query: 265 LYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRGQETV 324
DTSAQ H+ + + S +++ L+ E+ E G ++
Sbjct: 242 ----DTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPE-------LDNLGLDSF 290
Query: 325 SSELKKPLGPASFNLSEYFRQFLLPQ----------NECELHDFRLSFSQLKWDNWIVAP 374
SS GP L + + N C+ + F ++ WD+WI+AP
Sbjct: 291 SS------GPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAP 344
Query: 375 HRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEP 434
Y C+G C + H ++Q +++ K + CVP K P+S+L ++
Sbjct: 345 PGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLD- 403
Query: 435 DGSIAYK-EYEDMIATKCTCR 454
G + YK +YE M ++C CR
Sbjct: 404 KGVVTYKFKYEGMAVSECGCR 424
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 74.7 bits (182), Expect = 2e-13
Identities = 28/101 (27%), Positives = 55/101 (54%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
C H+ +SF L W +W++AP Y+ YC+G+C + + H ++Q++++ +
Sbjct: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD 360
Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+VP+ C P K S SVL + ++ +++ +M+ C C
Sbjct: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 73.6 bits (179), Expect = 4e-13
Identities = 28/101 (27%), Positives = 55/101 (54%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDS 412
C H+ +SF L W +W++AP Y+ YC+G+C + + H ++Q++++ +
Sbjct: 301 CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPN 360
Query: 413 SVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+VP+ C P K S SVL + ++ +++ +M+ C C
Sbjct: 361 AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|153792495 growth differentiation factor 15 [Homo sapiens]
Length = 308
Score = 69.3 bits (168), Expect = 7e-12
Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYE 408
P C LH R S L W +W+++P C G CP + +H ++ ++
Sbjct: 207 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP---SQFRAANMHAQIKTSLHR 263
Query: 409 KLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+VP P CVPA Y+P+ VL + D ++ + Y+D++A C C
Sbjct: 264 LKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 307
>gi|239757187 PREDICTED: similar to growth differentiation factor 15
[Homo sapiens]
Length = 270
Score = 69.3 bits (168), Expect = 7e-12
Identities = 32/105 (30%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYE 408
P C LH R S L W +W+++P C G CP + +H ++ ++
Sbjct: 169 PGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACP---SQFRAANMHAQIKTSLHR 225
Query: 409 KLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+VP P CVPA Y+P+ VL + D ++ + Y+D++A C C
Sbjct: 226 LKPDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 68.2 bits (165), Expect = 1e-11
Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 28/169 (16%)
Query: 290 GPDQERSLSAYP-VGEEAAEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYFRQFLL 348
G D+E+ S P + +A + H R RRG E
Sbjct: 280 GADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKV--------------------- 318
Query: 349 PQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYE 408
N C F +SF + W++WI+AP Y+ YC+G+CP + GS + I +
Sbjct: 319 --NICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHY 376
Query: 409 KLDSSVP----RPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
++ P + CVP K P+S+L + +I K+ ++MI +C C
Sbjct: 377 RMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 64.7 bits (156), Expect = 2e-10
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 8/106 (7%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSP-VHTMVQNIIYEKLD 411
C D + F +L W +WI+ P Y YC G CP H GSP + + ++ L
Sbjct: 247 CCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCP---PHLAGSPGIAASFHSAVFSLLK 303
Query: 412 SSVPRPS----CVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
++ P P+ CVP PLS+L ++ +G++ + DM+ C C
Sbjct: 304 ANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 63.2 bits (152), Expect = 5e-10
Identities = 28/103 (27%), Positives = 50/103 (48%), Gaps = 1/103 (0%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK-LD 411
C ++ F+ + W+ WI++P ++ YC G C + H +Q+I+ +
Sbjct: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
Query: 412 SSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
+P P CVP K + L VL ++ + ++ K Y +M C CR
Sbjct: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 61.2 bits (147), Expect = 2e-09
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 3/106 (2%)
Query: 351 NECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYG--SPVHTMVQNIIYE 408
N C F + F + W++WI+AP Y YC+G CP + G S HT V N
Sbjct: 301 NLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRM 360
Query: 409 K-LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+ L+ C+P K S +S+L + + +I ++ +MI +C C
Sbjct: 361 RGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 57.8 bits (138), Expect = 2e-08
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 4/105 (3%)
Query: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYG--SPVHTMVQNIIYEKL 410
C +F + F ++ W +WI+ P Y +C G CP + G + HT V N++
Sbjct: 247 CCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANT 306
Query: 411 DSSVP--RPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
+ CVP PLS+L + D +I + DM+ C C
Sbjct: 307 AAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 57.4 bits (137), Expect = 3e-08
Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 7/104 (6%)
Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
++ C + + F WD WI+AP RY YC G+C +Y HT +++++
Sbjct: 278 ESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKY---PHT---HLVHQA 330
Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
P C P K SP+++L I Y + M+ +C C
Sbjct: 331 NPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 56.6 bits (135), Expect = 5e-08
Identities = 29/104 (27%), Positives = 45/104 (43%), Gaps = 7/104 (6%)
Query: 350 QNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK 409
++ C + + F WD WI+AP RY YC G C +Y HT +++ +
Sbjct: 310 ESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKY---PHT---HLVQQA 362
Query: 410 LDSSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTC 453
P C P K SP+++L I Y + M+ +C C
Sbjct: 363 NPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
>gi|4504697 inhibin alpha subunit precursor [Homo sapiens]
Length = 366
Score = 45.8 bits (107), Expect = 8e-05
Identities = 33/128 (25%), Positives = 49/128 (38%), Gaps = 7/128 (5%)
Query: 331 PLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAV 390
P P++ L + + C +SF +L W+ WIV P + YC G C +
Sbjct: 240 PWSPSALRLLQRPPEEPAAHANCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHI 299
Query: 391 GHRYGSPV----HTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDG-SIAYKEYED 445
PV T Q Y L + P + +P PL V T G S Y+ +
Sbjct: 300 PPNLSLPVPGAPPTPAQP--YSLLPGAQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPN 357
Query: 446 MIATKCTC 453
++ C C
Sbjct: 358 LLTQHCAC 365
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,518,321
Number of Sequences: 37866
Number of extensions: 857391
Number of successful extensions: 1979
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1913
Number of HSP's gapped (non-prelim): 55
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.