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Search of human proteins with 4826870
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826870 nucleobindin 2 [Homo sapiens]
(420 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826870 nucleobindin 2 [Homo sapiens] 849 0.0
gi|20070228 nucleobindin 1 [Homo sapiens] 493 e-139
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 76 5e-14
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 71 2e-12
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 71 2e-12
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 71 2e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 70 4e-12
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 68 1e-11
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 68 2e-11
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 67 3e-11
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 66 5e-11
gi|148746195 trichohyalin [Homo sapiens] 60 3e-09
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 60 5e-09
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 60 5e-09
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 58 1e-08
gi|71061468 centromere protein E [Homo sapiens] 58 2e-08
gi|9910266 kinesin family member 15 [Homo sapiens] 57 2e-08
gi|239752551 PREDICTED: hypothetical protein [Homo sapiens] 56 5e-08
gi|38044112 restin isoform b [Homo sapiens] 56 7e-08
gi|4506751 restin isoform a [Homo sapiens] 56 7e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 55 9e-08
gi|221219020 NYD-SP11 protein [Homo sapiens] 55 1e-07
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 55 1e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 55 1e-07
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 55 2e-07
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 54 2e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 54 3e-07
gi|110815815 centlein isoform 1 [Homo sapiens] 54 3e-07
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 53 6e-07
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 53 6e-07
>gi|4826870 nucleobindin 2 [Homo sapiens]
Length = 420
Score = 849 bits (2193), Expect = 0.0
Identities = 420/420 (100%), Positives = 420/420 (100%)
Query: 1 MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQ 60
MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQ
Sbjct: 1 MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQ 60
Query: 61 VIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKA 120
VIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKA
Sbjct: 61 VIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKA 120
Query: 121 KLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKY 180
KLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKY
Sbjct: 121 KLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKY 180
Query: 181 EMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLD 240
EMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLD
Sbjct: 181 EMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLD 240
Query: 241 PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREH 300
PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREH
Sbjct: 241 PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREH 300
Query: 301 VMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE 360
VMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE
Sbjct: 301 VMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE 360
Query: 361 LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI 420
LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI
Sbjct: 361 LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI 420
>gi|20070228 nucleobindin 1 [Homo sapiens]
Length = 461
Score = 493 bits (1268), Expect = e-139
Identities = 255/415 (61%), Positives = 309/415 (74%), Gaps = 14/415 (3%)
Query: 13 LLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFR 72
LL+ LL A+ AVP++ + E+ E PDTGLYY YL++VIDVLETD HFR
Sbjct: 15 LLLLLLLRAVLAVPLERGAPNKE-----ETPATESPDTGLYYHRYLQEVIDVLETDGHFR 69
Query: 73 EKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQD--IGM 130
EKLQ A+ E+IKSG+LS+ELD VSHHVRTKLDELKRQEV RLRML+KAK+D+ QD + +
Sbjct: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
Query: 131 DHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERRE 190
DH LLKQF+HL+ N FE+ DL++LI+ AT DL YD HEEFK+YEM+KEHERR
Sbjct: 130 DHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRR 189
Query: 191 YLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFF 250
YL++L EE+RKE E K EE +++H HPKVN PGS+ QLKEVWEE DGLDPN F+PKTFF
Sbjct: 190 YLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFF 249
Query: 251 KLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKD 310
LHD+NSDG LDEQELEALFTKELEKVYDPKNEEDDM EMEEERLRMREHVM VDTN+D
Sbjct: 250 ILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQD 309
Query: 311 RLVTLEEFLKATEKKEFLEP-DSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQ 369
RLVTLEEFL +T++KEF + + WET++ +TEEEL+ +E +A +E EL KA L
Sbjct: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
Query: 370 KQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ------GIPPSGPAGELKFEP 418
++ E L R +LEAQK E Q + MEQ+K QQ P + P G+LKF P
Sbjct: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHP 424
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 76.3 bits (186), Expect = 5e-14
Identities = 81/379 (21%), Positives = 176/379 (46%), Gaps = 61/379 (16%)
Query: 54 YDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHH---VRTKLDELKRQE 110
Y E L + D L + +R + +++E K+ +L ++L LV ++ + ELKR+
Sbjct: 182 YIEELTKERDALSLEL-YRNTITDEELKE-KNAKLQEKLQLVESEKSEIQLNVKELKRK- 238
Query: 111 VGRLRMLI-----KAKLD----SLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKA 161
+ R ++L+ +A+ D LQ + QA +++ + N LN + E + +
Sbjct: 239 LERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK-----MWRQ 293
Query: 162 ATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRK-------EEESKFEEMKKKH 214
E +K + +E K E ++ R+E + EEK + E+E K E+++K
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 215 ENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKEL 274
K+ K Q +E E + QE EA ++
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQE------------------------KRQEQEAKMWRQE 389
Query: 275 EKVYDPKN---EEDDMVEMEEERLRMREHVM----NEVDTNKDRLVTLEEFLKATEKKEF 327
EK+ + + E+++M++ +EE++ +E M E+ ++++ EE ++ EKK
Sbjct: 390 EKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIR 449
Query: 328 LEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQK- 386
+ + ++ EE++ E E + QE +++++ +++++Q+E+++ Q ++ Q+
Sbjct: 450 EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE 509
Query: 387 --LEYHQVIQQMEQKKLQQ 403
E +++Q+ E+K +Q
Sbjct: 510 KIREQEEMMQEQEEKMWEQ 528
Score = 57.4 bits (137), Expect = 2e-08
Identities = 74/352 (21%), Positives = 159/352 (45%), Gaps = 59/352 (16%)
Query: 58 LKQVIDVLETDKHFREKLQKAD--IEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLR 115
L+Q + + T K +KAD IEE+ R + L+L + T DE +++ +L+
Sbjct: 165 LEQALSAVATQK------KKADRYIEELTKERDALSLELYRN---TITDEELKEKNAKLQ 215
Query: 116 MLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHE 175
++ +I ++ + L ++ + L P + + D L K S
Sbjct: 216 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS----------V 265
Query: 176 EFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKK-HENHPKVNHPGSKDQLKE--V 232
K ++E+E L EEK +E K +E ++K E K+ K + +E +
Sbjct: 266 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM 325
Query: 233 WEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEE 292
WE+ + + ++ E ++ KE EK+ + E+ M E+
Sbjct: 326 WEKEEKM-----------------------RRQEEMMWEKE-EKI---RELEEKM--HEQ 356
Query: 293 ERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYEN 352
E++R +E E + +++ E+ K ++E + + +Q++ E+E K E
Sbjct: 357 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE- 415
Query: 353 IIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQM-EQKKLQQ 403
QE ++ ++ +E+Q+Q+E+++RQ +++ Q+ + + +++ EQ+++ Q
Sbjct: 416 ----QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 463
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 71.2 bits (173), Expect = 2e-12
Identities = 73/361 (20%), Positives = 174/361 (48%), Gaps = 44/361 (12%)
Query: 67 TDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLD--- 123
TD+ +EK A+++E K + E + +V+ +L+R ++ + ++ + D
Sbjct: 212 TDEELKEK--NAELQE-KLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLG 268
Query: 124 -SLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEM 182
LQ + QA +++ + N LN + E + + E +K +E K E
Sbjct: 269 KELQSVSAKLQAQVEENELWNLLNQQQEEK-----MWRQEEKIQEQEEKMCEQELKIREQ 323
Query: 183 MKEHERREYLKTLNEEKRKEEESKFEEMKKK-HENHPKVNHPGSKDQLKEVWEETDGLDP 241
++ R+E EEK +E+E K ++K E K+ ++Q +++W + + +
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKI-----REQEEKMWRQEEKIRE 378
Query: 242 NDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKN---EEDDMVEMEEERLRMR 298
D K+ + + + E+++ K EK++ + E+D+ + +EE + +
Sbjct: 379 QDE------KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Query: 299 EHVMNEVDT----NKDRLVTLEEFLKATEKK------------EFLEPDSWETLDQQQFF 342
E + E++ +++L +EE ++ E+K E ++ +T Q++
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLL 492
Query: 343 TEEE-LKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKL 401
+EE + E E + QE ++ ++ +++Q+Q+E++QRQ +++ Q++ Q ++M+++++
Sbjct: 493 KQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV 552
Query: 402 Q 402
+
Sbjct: 553 R 553
Score = 65.1 bits (157), Expect = 1e-10
Identities = 69/349 (19%), Positives = 161/349 (46%), Gaps = 44/349 (12%)
Query: 64 VLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHV--RTKLDELKRQEVGRLRMLIKAK 121
+LE HF ++ E +L+KE D S + T DE +++ L+ ++
Sbjct: 175 LLEETLHFDHAVRMGTYIE----KLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLV 230
Query: 122 LDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYE 181
+I ++ + L ++ + L P + + D L K S K
Sbjct: 231 ESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS----------VSAKLQA 280
Query: 182 MMKEHERREYLKTLNEEKRKEEESKFEEMKKKH-ENHPKVNHPGSKDQLKEVWEETDGLD 240
++E+E L EEK +E K +E ++K E K+ ++Q +++W + + +
Sbjct: 281 QVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKI-----REQEEKMWRQEEKMH 335
Query: 241 PNDFDPKTFFKLHDVNSDGFLDEQEL---EALFTKELEKVYDPKN---EEDDMVEMEEER 294
+ K+ + + E+++ E ++ EK++ + E+D+ ++ +EE
Sbjct: 336 EQEE------KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEE 389
Query: 295 LRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENII 354
+ +E + E + + +E + EKK + + +++ + EE+++E E ++
Sbjct: 390 MWRQEEKIREQEEKR------QEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMM 443
Query: 355 ALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
QE +L++ +++Q+++E++Q Q ++++ Q+ + IQ+ E+K +Q
Sbjct: 444 QDQEEKLREVEEKMQEEEEKMQEQEEKIQRQE----EKIQEQEEKTWRQ 488
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 71.2 bits (173), Expect = 2e-12
Identities = 73/361 (20%), Positives = 174/361 (48%), Gaps = 44/361 (12%)
Query: 67 TDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLD--- 123
TD+ +EK A+++E K + E + +V+ +L+R ++ + ++ + D
Sbjct: 212 TDEELKEK--NAELQE-KLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLG 268
Query: 124 -SLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEM 182
LQ + QA +++ + N LN + E + + E +K +E K E
Sbjct: 269 KELQSVSAKLQAQVEENELWNLLNQQQEEK-----MWRQEEKIQEQEEKMCEQELKIREQ 323
Query: 183 MKEHERREYLKTLNEEKRKEEESKFEEMKKK-HENHPKVNHPGSKDQLKEVWEETDGLDP 241
++ R+E EEK +E+E K ++K E K+ ++Q +++W + + +
Sbjct: 324 EEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKI-----REQEEKMWRQEEKIRE 378
Query: 242 NDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKN---EEDDMVEMEEERLRMR 298
D K+ + + + E+++ K EK++ + E+D+ + +EE + +
Sbjct: 379 QDE------KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Query: 299 EHVMNEVDT----NKDRLVTLEEFLKATEKK------------EFLEPDSWETLDQQQFF 342
E + E++ +++L +EE ++ E+K E ++ +T Q++
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLL 492
Query: 343 TEEE-LKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKL 401
+EE + E E + QE ++ ++ +++Q+Q+E++QRQ +++ Q++ Q ++M+++++
Sbjct: 493 KQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV 552
Query: 402 Q 402
+
Sbjct: 553 R 553
Score = 66.2 bits (160), Expect = 5e-11
Identities = 69/349 (19%), Positives = 162/349 (46%), Gaps = 44/349 (12%)
Query: 64 VLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHV--RTKLDELKRQEVGRLRMLIKAK 121
+LE HF ++ E +L+KE D +S + T DE +++ L+ ++
Sbjct: 175 LLEETLHFDHAVRMGTYIE----KLTKERDALSLELYRNTITDEELKEKNAELQEKLRLV 230
Query: 122 LDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYE 181
+I ++ + L ++ + L P + + D L K S K
Sbjct: 231 ESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS----------VSAKLQA 280
Query: 182 MMKEHERREYLKTLNEEKRKEEESKFEEMKKKH-ENHPKVNHPGSKDQLKEVWEETDGLD 240
++E+E L EEK +E K +E ++K E K+ ++Q +++W + + +
Sbjct: 281 QVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKI-----REQEEKMWRQEEKMH 335
Query: 241 PNDFDPKTFFKLHDVNSDGFLDEQEL---EALFTKELEKVYDPKN---EEDDMVEMEEER 294
+ K+ + + E+++ E ++ EK++ + E+D+ ++ +EE
Sbjct: 336 EQEE------KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEE 389
Query: 295 LRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENII 354
+ +E + E + + +E + EKK + + +++ + EE+++E E ++
Sbjct: 390 MWRQEEKIREQEEKR------QEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMM 443
Query: 355 ALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
QE +L++ +++Q+++E++Q Q ++++ Q+ + IQ+ E+K +Q
Sbjct: 444 QDQEEKLREVEEKMQEEEEKMQEQEEKIQRQE----EKIQEQEEKTWRQ 488
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 70.9 bits (172), Expect = 2e-12
Identities = 64/354 (18%), Positives = 175/354 (49%), Gaps = 22/354 (6%)
Query: 66 ETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSL 125
+ +K +R++ + + EE K +++ +R + ++++RQE + + K+
Sbjct: 359 QEEKMWRQEEKIQEWEE-KIQEQEEKIREQEEKIREQEEKMRRQE--EMMWEKEEKMRRQ 415
Query: 126 QDIGMDHQALLKQFDHLNHLNPDKFESTDLDM----LIKAATSDLEHYDKTRHEEFKKYE 181
+++ + + +++ + + +K + M I+ + +K R +E ++ +
Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 475
Query: 182 MMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDP 241
K + E ++ E+ R++EE + + +K HE K+ + + +E+W + + +
Sbjct: 476 EAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQE-KIREEEKRQEQEEMWRQEEKIRE 534
Query: 242 NDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKN---EEDDMVEMEEERLRMR 298
+ + K+H+ + +QE E ++ +E EK++D + E+++ V +EE++R +
Sbjct: 535 QEEIWRQKEKIHEQEEK--IRKQE-EKMWRQE-EKMHDQEEKIREQEEKVWRQEEKIREQ 590
Query: 299 EHVMNE----VDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENII 354
E + E + ++ EE + E+K + + + +++ EE+++E E I
Sbjct: 591 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKI 650
Query: 355 ALQENELKKKADELQKQKEELQRQHDQL---EAQKLEYHQVIQQMEQKKLQQGI 405
QE +++++ + +Q+Q+E++ Q +++ E + E + +++ E+K +Q +
Sbjct: 651 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV 704
Score = 69.7 bits (169), Expect = 5e-12
Identities = 82/391 (20%), Positives = 181/391 (46%), Gaps = 47/391 (12%)
Query: 54 YDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHH---VRTKLDELKRQE 110
Y E L + D L + +R + +++E K+ +L ++L LV ++ + ELKR+
Sbjct: 255 YIEELTKERDALSLEL-YRNTITDEELKE-KNAKLQEKLQLVESEKSEIQLNVKELKRK- 311
Query: 111 VGRLRMLI-----KAKLD----SLQDIGMDHQALLKQFDHLNHLNPDKFEST-------- 153
+ R ++L+ +A+ D LQ + QA +++ + N LN + E
Sbjct: 312 LERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ 371
Query: 154 -------DLDMLIKAATSDL-EHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRK---- 201
+ + I+ + E +K R +E +E ++ R+E + EEK +
Sbjct: 372 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 431
Query: 202 ---EEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSD 258
E+E K E+++K K+ K Q +E E + + + K + + +
Sbjct: 432 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE--KRQEQEAKMWRQEEKIREQ 489
Query: 259 GFLDEQELEALFTKELEKVYDP-KNEEDDMVEMEEERLRMREHV--MNEVDTNKDRLVTL 315
++ E ++ +E EK+++ K E++ + +EE R E + E+ K+++
Sbjct: 490 EEKIREQEEKMWRQE-EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQ 548
Query: 316 EEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEEL 375
EE ++ E+K + + + +++ EE++ E I QE +++++ +++++Q+E
Sbjct: 549 EEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMT 608
Query: 376 QRQHDQL---EAQKLEYHQVIQQMEQKKLQQ 403
Q Q +++ E + E + +Q+ E+K +Q
Sbjct: 609 QEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ 639
Score = 65.9 bits (159), Expect = 7e-11
Identities = 50/238 (21%), Positives = 123/238 (51%), Gaps = 37/238 (15%)
Query: 173 RHEEFKKYEMMKEHERREYLKTL--NEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLK 230
+ E+ + E ++E E+R+ + + EEK +E+E + + +K HE K+ + Q +
Sbjct: 503 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI-----RKQEE 557
Query: 231 EVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQEL---EALFTKELEKVYDPKN---EE 284
++W + + K+HD E+++ E ++ EK+ + + E+
Sbjct: 558 KMWRQEE-------------KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQ 604
Query: 285 DDMVEMEEERLRMREHVMNE----VDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQ 340
++M + +EE++ +E M E + ++++ EE ++ EKK + + +Q++
Sbjct: 605 EEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK--IREQEEKIREQEE 662
Query: 341 FFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQ 398
E+E K +E QE ++ ++ +++Q+Q+E+++RQ +++ Q++ Q ++M++
Sbjct: 663 MMQEQEEKMWE-----QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715
Score = 60.1 bits (144), Expect = 4e-09
Identities = 47/225 (20%), Positives = 117/225 (52%), Gaps = 25/225 (11%)
Query: 167 EHYDKTRHEEFKKYEMMKEHE----RREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNH 222
E + + E +++ E ++E E ++E + E+ RK+EE + + +K H+ K+
Sbjct: 516 EEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKI-- 573
Query: 223 PGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKN 282
++Q ++VW + + + + + K + + + +++ E + +E EK+ + +
Sbjct: 574 ---REQEEKVWRQEEKI--REQEEKIREQEEKIREQEEMTQEQEEKMGEQE-EKMCEQEE 627
Query: 283 ---EEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQ 339
E+++ + +EE++R +E + E ++++ EE ++ E+K WE +++
Sbjct: 628 KMQEQEEKMRRQEEKIREQEKKIRE---QEEKIREQEEMMQEQEEK------MWEQ-EEK 677
Query: 340 QFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEA 384
EE+++E E + QE ++ ++ L++Q+E++Q + LEA
Sbjct: 678 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 53.5 bits (127), Expect = 3e-07
Identities = 73/350 (20%), Positives = 163/350 (46%), Gaps = 62/350 (17%)
Query: 58 LKQVIDVLETDKHFREKLQKAD--IEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLR 115
L+Q + + T K +KAD IEE+ R + L+L + T DE +++ +L+
Sbjct: 238 LEQALSAVATQK------KKADRYIEELTKERDALSLELYRN---TITDEELKEKNAKLQ 288
Query: 116 MLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHE 175
++ +I ++ + L ++ + L P + + D L K S
Sbjct: 289 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS----------V 338
Query: 176 EFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKK-HENHPKVNHPGSKDQLKEVWE 234
K ++E+E L EEK +E K +E ++K E K+ ++Q +++ E
Sbjct: 339 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI-----REQEEKIRE 393
Query: 235 ETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEER 294
+ + + ++ E ++ KE EK+ + +E+ M E +EE+
Sbjct: 394 QEEKM-----------------------RRQEEMMWEKE-EKM---RRQEEMMWE-KEEK 425
Query: 295 LRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENII 354
+R +E +M E ++++ LEE + EK + + ++++ +E+ +E E +
Sbjct: 426 MRRQEEMMWE---KEEKIRELEEKMHEQEK---IREQEEKRQEEEKIREQEKRQEQEAKM 479
Query: 355 ALQENELKKKADELQKQKEELQRQHDQL-EAQKLEYHQVIQQMEQKKLQQ 403
QE +++++ +++++Q+E++ RQ +++ E +K+ + Q+ E+ Q+
Sbjct: 480 WRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 70.1 bits (170), Expect = 4e-12
Identities = 61/350 (17%), Positives = 167/350 (47%), Gaps = 27/350 (7%)
Query: 59 KQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLI 118
+Q + E ++ +E+ +K +E K +++ + K ++++RQE +
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE--EMMWEK 361
Query: 119 KAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDM----LIKAATSDLEHYDKTRH 174
+ K+ +++ + + +++ + + +K + M I+ + +K R
Sbjct: 362 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE 421
Query: 175 EEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWE 234
+E ++ + K + E ++ E+ R++E+ + + +K HE K+ + + +E+W
Sbjct: 422 QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE-KIREEEKRQEQEEMWR 480
Query: 235 ETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEER 294
+ + + + + K+H E E K+ EKV+ +++ + +EE+
Sbjct: 481 QEEKIHEQEEIWRQKEKMH-----------EQEEKIRKQEEKVW----RQEEKIREQEEK 525
Query: 295 LRMREHVM-NEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENI 353
+R +E M + + +++ E K E+++ E + + + + + EE+++E E
Sbjct: 526 IREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEK 585
Query: 354 IALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
+ QE +++++ ++ Q+Q+E++ +Q +++ Q+ + IQ+ E+K +Q
Sbjct: 586 VWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE----EKIQEQEEKIREQ 631
Score = 65.1 bits (157), Expect = 1e-10
Identities = 50/253 (19%), Positives = 127/253 (50%), Gaps = 19/253 (7%)
Query: 167 EHYDKTRHEEFKKY---EMMKEHERR----EYLKTLNEEKRKEEESKFEEMKKKHENHPK 219
E +K R +E K + E ++E E + E EEK +E+E + E +K HE
Sbjct: 500 EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKI 559
Query: 220 VNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYD 279
++Q ++W + + + + + ++ + + QE E K+ EK+ +
Sbjct: 560 WEEEKRQEQEDKMWRQEEKIREQE---EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIRE 616
Query: 280 PKN---EEDDMVEMEEERLRMREHVMNEVDTN----KDRLVTLEEFLKATEKKEFLEPDS 332
+ E+++ + +EE++R +E + E + ++++ EE ++ E+ + + +
Sbjct: 617 QEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEK 676
Query: 333 WETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQ--KLEYH 390
+++ EE+++E E ++ QE ++ ++ +++ +Q+E++Q Q +++ Q K+
Sbjct: 677 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 736
Query: 391 QVIQQMEQKKLQQ 403
+V + +++K+Q+
Sbjct: 737 EVRLRQQEEKMQE 749
Score = 54.3 bits (129), Expect = 2e-07
Identities = 74/355 (20%), Positives = 160/355 (45%), Gaps = 40/355 (11%)
Query: 58 LKQVIDVLETDKHFREKLQKAD--IEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLR 115
L+Q + + T K +KAD IEE+ R + L+L + T DE +++ +L+
Sbjct: 177 LEQALSAVATQK------KKADRYIEELTKERDALSLELYRN---TITDEELKEKNAKLQ 227
Query: 116 MLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHE 175
++ +I ++ + L ++ + L P + + D L K S
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS----------V 277
Query: 176 EFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKK-HENHPKVNHPGSKDQLKEVWE 234
K ++E+E L EEK +E K +E ++K E K+ +++++E E
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE--QEEKIREQEE 335
Query: 235 ETDGLDPNDFDPKTFFKLHDV---NSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEME 291
+ + ++ + + + + + QE E ++ KE + +++M+ +
Sbjct: 336 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE-EMMWEKE-----EKMRRQEEMMWEK 389
Query: 292 EERLRMREHVMNEVD--TNKDRLVTLEEFLKATEKKEFLEPDSW----ETLDQQQFFTEE 345
EE++R E M+E + ++ EE ++ EK++ E W + +Q++ E+
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449
Query: 346 ELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK 400
E K + + E E K + +E ++++EE+ RQ +++ Q+ + Q + EQ++
Sbjct: 450 EKKMWRQEEKIHEQE-KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/155 (21%), Positives = 80/155 (51%), Gaps = 12/155 (7%)
Query: 261 LDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHV-----MNEVDTNKDRLVTL 315
+ ++EL+ K EK+ ++E+ ++ +E R E ++ D L
Sbjct: 214 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 316 EEFLKATEKKEFLEPDSWETLDQQQ----FFTEEELKEYENIIALQENELKKKADELQKQ 371
+ + A + + E + W L+QQQ + EE+++E+E I QE +++++ +++++Q
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 372 KEELQRQHDQL---EAQKLEYHQVIQQMEQKKLQQ 403
+E+++RQ + + E + +++ + E+K +Q
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 68.2 bits (165), Expect = 1e-11
Identities = 60/369 (16%), Positives = 175/369 (47%), Gaps = 37/369 (10%)
Query: 59 KQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLI 118
+Q + E ++ +E+ +K +E K +++ + K ++++RQE +
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE--EMMWEK 361
Query: 119 KAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFK 178
+ K+ L+++ + + +++ + H I+ + +K R +E +
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEK----------IREQEEKRQEEEKIREQEKR 411
Query: 179 KYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDG 238
+ + K + E ++ E+ R++E+ + + +K HE K+ + + +E+W + +
Sbjct: 412 QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE-KIREEEKRQEQEEMWRQEEK 470
Query: 239 LDPNDFDPKTFFKLHDVNSDGFLDEQ---------ELEALFTKELEKVYDPKN---EEDD 286
+ + + K+H+ +E+ + E ++ EK++ + E+++
Sbjct: 471 IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEE 530
Query: 287 MVEMEEERLRMREHVMNEVDTN----------KDRLVTLEEFLKATEKKEFLEPDSWETL 336
+ +EE++R +E +M E + ++++ EE ++ E+K + +
Sbjct: 531 KIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQ 590
Query: 337 DQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQ--KLEYHQVIQ 394
+++ + EE+++E E ++ QE ++ ++ +++ +Q+E++Q Q +++ Q K+ +V
Sbjct: 591 EEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 650
Query: 395 QMEQKKLQQ 403
+ +++K+Q+
Sbjct: 651 RQQEEKMQE 659
Score = 67.4 bits (163), Expect = 2e-11
Identities = 79/396 (19%), Positives = 182/396 (45%), Gaps = 52/396 (13%)
Query: 54 YDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHH---VRTKLDELKRQE 110
Y E L + D L + +R + +++E K+ +L ++L LV ++ + ELKR+
Sbjct: 194 YIEELTKERDALSLEL-YRNTITDEELKE-KNAKLQEKLQLVESEKSEIQLNVKELKRK- 250
Query: 111 VGRLRMLI-----KAKLD----SLQDIGMDHQALLKQFDHLNHLNPDKFEST-------- 153
+ R ++L+ +A+ D LQ + QA +++ + N LN + E
Sbjct: 251 LERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ 310
Query: 154 -------DLDMLIKAATSDL-EHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRK---- 201
+ + I+ + E +K R +E +E ++ R+E + EEK +
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEE 370
Query: 202 ---EEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSD 258
E+E K E+++K K+ K Q +E E + + ++ + +
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE---AKMWRQEEKIRE 427
Query: 259 GFLDEQELEALFTKELEKVYDP-------KNEEDDMVEMEEERLRMREHVMNEVDT--NK 309
+E E ++ EK+++ K +E + + +EE++R +E + + + +
Sbjct: 428 QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQ 487
Query: 310 DRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQ 369
+++ EE + E+K + + +++ + EE+++E E I QE +++++ + +Q
Sbjct: 488 EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQ 547
Query: 370 KQKEELQRQHDQLEAQK--LEYHQVIQQMEQKKLQQ 403
+Q+E++ Q ++++ Q+ + I++ E+K +Q
Sbjct: 548 EQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQ 583
Score = 57.0 bits (136), Expect = 3e-08
Identities = 50/230 (21%), Positives = 116/230 (50%), Gaps = 30/230 (13%)
Query: 167 EHYDKTRHEEFKKYEMMKEHER--REYLKTLNEEK-RKEEESKFEEMKKKHENHPKVNHP 223
E + + E +++ E ++E E R+ K +EK RK+EE + + +K H+ K+
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKI--- 511
Query: 224 GSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKV--YDPK 281
++Q +++W + + + + K+ + +E E + ++ EK+ + K
Sbjct: 512 --REQEEKMWRQEEKIREQEE------KIREQEEK----IREQEEMMQEQEEKMGEQEEK 559
Query: 282 NEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFL-----KATEKKEFLEPDSWETL 336
+E + + +EE++R +E + E K+++ EE + K E++E ++ +
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIRE---QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMW 616
Query: 337 DQQQFFTEEE--LKEYENIIALQENELKKKADELQKQKEELQRQHDQLEA 384
+Q++ E+E ++E E + QE ++ ++ L++Q+E++Q + LEA
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 51.6 bits (122), Expect = 1e-06
Identities = 76/371 (20%), Positives = 163/371 (43%), Gaps = 80/371 (21%)
Query: 58 LKQVIDVLETDKHFREKLQKAD--IEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLR 115
L+Q + + T K +KAD IEE+ R + L+L + T DE +++ +L+
Sbjct: 177 LEQALSAVATQK------KKADRYIEELTKERDALSLELYRN---TITDEELKEKNAKLQ 227
Query: 116 MLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHE 175
++ +I ++ + L ++ + L P + + D L K S
Sbjct: 228 EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS----------V 277
Query: 176 EFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKK-HENHPKVNHPGSKDQLKEVWE 234
K ++E+E L EEK +E K +E ++K E K+ ++Q +++ E
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKI-----REQEEKIRE 332
Query: 235 ETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEER 294
+ + + ++ E ++ KE EK+ + +E+ M E EE+
Sbjct: 333 QEEKM-----------------------RRQEEMMWEKE-EKM---RRQEEMMWEKEEKM 365
Query: 295 LRMREHVMNEVDTNKDRLVTLEEFL-----------KATEKKEFLEPDSWETLDQQQFFT 343
R+ E + + ++++ LEE + K E+++ E + + + + +
Sbjct: 366 RRLEEMMWEK----EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 421
Query: 344 EEELKEYENIIALQENEL-----------KKKADELQKQKEELQRQHDQLEAQKLEYHQV 392
EE+++E E I QE ++ K + +E ++++EE+ RQ +++ Q+ + Q
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 481
Query: 393 IQQMEQKKLQQ 403
+ EQ+K+++
Sbjct: 482 EKMHEQEKIRK 492
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 67.8 bits (164), Expect = 2e-11
Identities = 76/340 (22%), Positives = 162/340 (47%), Gaps = 36/340 (10%)
Query: 76 QKAD--IEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQ 133
+KAD IEE+ R + L+L + + +ELK++ L A+ + +I ++ +
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITN--EELKKKNAELQEKLPLAESEK-SEIQLNVK 249
Query: 134 ALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKY---EMMKEHE--- 187
L ++ + L P +T + + + E K R +E K + E ++E E
Sbjct: 250 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 309
Query: 188 RREYLKTLNEEKR-KEEESKFEEMKK--KHENHPKVNHPGSKDQLKEVWEETDGLDPNDF 244
R + K +EKR +E+E + E +K + + + ++Q +++WE+ +
Sbjct: 310 REQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEE------- 362
Query: 245 DPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNE 304
K+ + + E+ L + E+ +++E+ M E ++ERLR +E M E
Sbjct: 363 ------KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE-QDERLREKEERMRE 415
Query: 305 VDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEE-LKEYENIIALQENELKK 363
+ +++ + E K E+++ +T DQ++ EEE ++E E + +E +++
Sbjct: 416 QEKMWEQVEKMREEKKMQEQEK-------KTRDQEEKMQEEERIREREKKMREEEETMRE 468
Query: 364 KADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
+ +++QKQ+E + Q ++ Q+ Q + EQ+K+Q+
Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 508
Score = 63.5 bits (153), Expect = 3e-10
Identities = 73/388 (18%), Positives = 173/388 (44%), Gaps = 66/388 (17%)
Query: 66 ETDKHFREKLQKADIEEIKSGRLSK---ELDLVSHHVRTKLDELKRQEVGRLRMLIKAKL 122
E D+ REK ++ +E ++ K E + +T+ E K QE R+R K
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
Query: 123 DSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEM 182
+ + + + + KQ +++ +++ L L +K + +E K +E
Sbjct: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP----EQKEKLWEQEKMQEQEEKIWEQ 516
Query: 183 MKEHERREYL-----KTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETD 237
++ +E + K +EK +E+E + E ++K +DQ +++W++ +
Sbjct: 517 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK-----------MRDQEQKMWDQEE 565
Query: 238 GLD--PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPK-NEEDDMVEMEEER 294
++ + + KT+ + + + + E+E + +E+ + + K E+++ ++ +EE+
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
Query: 295 LRMREHVMNE------------------------VDTNKDRLVTLEEFLKATEKKEFLEP 330
+ +E M E + K++L E+ ++ EK + E
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK-MQEQEKMQEQEE 684
Query: 331 DSWE--------------TLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQ 376
WE T DQ++ EE ++E E + +E ++++ +++Q+Q+E++Q
Sbjct: 685 KIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQ 744
Query: 377 RQHDQL-EAQKLEYHQVIQQMEQKKLQQ 403
Q +++ E ++ + Q + EQ++L +
Sbjct: 745 EQEEEMWEQEEKMWEQEEKMWEQQRLPE 772
Score = 60.5 bits (145), Expect = 3e-09
Identities = 45/236 (19%), Positives = 121/236 (51%), Gaps = 23/236 (9%)
Query: 171 KTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLK 230
KT+ +E K ++ ++ E ++ ++ R+EEE E+ +K E K+ ++Q +
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM-----QEQEE 624
Query: 231 EVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQEL--EALFTKELEKVYD-PKNEEDDM 287
++WE+ + + + K+ + + E+++ + ++ EK+++ K +E +
Sbjct: 625 KMWEQEEKMQEQEE------KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678
Query: 288 VEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEEL 347
++ +EE++ +E + + T E+ K ++++ E +S +++ EE +
Sbjct: 679 MQEQEEKIWEQEKMEKK---------TQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729
Query: 348 KEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
+E E + QE +++++ +E+ +Q+E++ Q +++ Q+ Q + E +K+Q+
Sbjct: 730 REQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785
Score = 60.1 bits (144), Expect = 4e-09
Identities = 60/265 (22%), Positives = 127/265 (47%), Gaps = 20/265 (7%)
Query: 154 DLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERR----EYLKTLNEEKRKEEESKFEE 209
D + ++ T + E + E+ ++ E M+E E++ E + EEK +E+E K +E
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 210 MKKKH-ENHPKVNHPGSK--DQLKEVWEETDGLDPNDFDPKTFFKLHD---VNSDGFLDE 263
++K E K+ K +Q +++WE+ + + P+ KL + + + E
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 264 QELEALFTKELEKVYDPKNEE--DDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKA 321
QE + +++EK + ++ D EEE +R RE M E + + E+ K
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE-----MMREQEEKM 736
Query: 322 TEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQK---EELQRQ 378
E++E ++ E +Q++ E+E K +E ++ E + +++Q+Q+ E+ ++
Sbjct: 737 QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKM 796
Query: 379 HDQLEAQKLEYHQVIQQMEQKKLQQ 403
DQ E + + ++ Q E+ + Q+
Sbjct: 797 RDQEEKMRGQEEKMRGQEEKMRGQE 821
Score = 55.1 bits (131), Expect = 1e-07
Identities = 48/242 (19%), Positives = 111/242 (45%), Gaps = 9/242 (3%)
Query: 167 EHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKF------EEMKKKHENHPKV 220
E +K + +E K +E ++ + +E EEK E+E K E K+K H K+
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
Query: 221 NHPGS-KDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYD 279
++Q +++WE+ K + + + + E+E + +E+ + +
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 280 PK--NEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLD 337
K +E+ M E EEE E + + + ++ E+ K E ++ E + +
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 338 QQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQME 397
++ EE+++ E + QE +++ + +++ Q+E++ Q +++ Q+ + ++ME
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKME 853
Query: 398 QK 399
+K
Sbjct: 854 EK 855
Score = 53.9 bits (128), Expect = 3e-07
Identities = 51/258 (19%), Positives = 123/258 (47%), Gaps = 48/258 (18%)
Query: 166 LEHYDKTRHEEFKKYEM--MKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHP 223
++ +K + +E K +E M++ + + KT ++EK +EEES E KK E +
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
Query: 224 GSK---------DQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKEL 274
K +Q +E+WE+ + + + + ++Q L ++
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQE--------------EKMWEQQRLP----EQK 774
Query: 275 EKVYD-PKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSW 333
EK+++ K +E + + +EE++R +E M ++++ EE ++ E+K + + +
Sbjct: 775 EKLWEHEKMQEQEKIWEQEEKMRDQEEKMRG---QEEKMRGQEEKMRGQEEKMWGQEEKM 831
Query: 334 ETLDQQQFFTEEEL----KEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEY 389
+++ + EE++ ++ E + QE +++++ ++++ Q+E+++ Q +++ Q
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ---- 887
Query: 390 HQVIQQMEQKKLQQGIPP 407
E+K G PP
Sbjct: 888 -------EEKIYCVGSPP 898
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 67.0 bits (162), Expect = 3e-11
Identities = 49/227 (21%), Positives = 115/227 (50%), Gaps = 20/227 (8%)
Query: 187 ERREYLKTLNEEKRKEEES--KFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDF 244
E+ E + E+ +K+EE + EE +K E + Q ++V ++ + + +
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 245 DPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNE 304
+ + + EQE + L KE + + E+++ + +EE++R +E M E
Sbjct: 263 QMR--------EQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE 314
Query: 305 VDTNKDRLVTLEEFLKATEKKEFLEPDS-WETLDQ------QQFFTEEELKEYENIIALQ 357
++++ EE + E++ + + + WE +Q Q EE++++ E + Q
Sbjct: 315 ---QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQ 371
Query: 358 ENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQG 404
E +++K+ ++++KQ+E++++Q +Q+ QK + + +QM +++ Q G
Sbjct: 372 EEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMG 418
Score = 58.5 bits (140), Expect = 1e-08
Identities = 42/238 (17%), Positives = 115/238 (48%), Gaps = 18/238 (7%)
Query: 167 EHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSK 226
E K + ++ E M++ E + + +K++E+ K EE +K E + +
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMR 272
Query: 227 DQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDD 286
+Q +++ ++ + + + G +EQ E +++ + + E+++
Sbjct: 273 EQEEQMLKQKEQTEQEE-------------QTGEQEEQMREQ--EEQMREQEEQMREQEE 317
Query: 287 MVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEE 346
+ +EE++ +E M E K+++ +E + E++ + + + ++Q EE+
Sbjct: 318 QMREQEEQMGKQEEQMWE---QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQ 374
Query: 347 LKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQG 404
+++ E + QE +++K+ +++ +QKE++ Q +Q+ Q+ + + +QM +++ G
Sbjct: 375 MRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432
Score = 48.9 bits (115), Expect = 9e-06
Identities = 27/122 (22%), Positives = 69/122 (56%), Gaps = 4/122 (3%)
Query: 283 EEDDMVEMEEERLRMREHVMNEVD----TNKDRLVTLEEFLKATEKKEFLEPDSWETLDQ 338
E++ V +E ++R +E M E + ++++ EE ++ E++ + + ++
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEE 234
Query: 339 QQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQ 398
Q EE++++ E + QE +++K+ +++++Q+E+++ Q +Q+ QK + Q Q EQ
Sbjct: 235 QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294
Query: 399 KK 400
++
Sbjct: 295 EE 296
Score = 40.4 bits (93), Expect = 0.003
Identities = 44/241 (18%), Positives = 110/241 (45%), Gaps = 17/241 (7%)
Query: 171 KTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKF----EEMKKKHENHPKVNHPGSK 226
K ++ E ++ + E E+ E + E KRK E K E ++ E + +
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVR 69
Query: 227 DQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTK-ELEKVYDPKNEED 285
+Q +V E+ + + + +G + EQE + + ++ + E++
Sbjct: 70 EQEGQVREQEGQVREQEGQVR--------EQEGQVREQEGQVREQEGQVREQEGQVREQE 121
Query: 286 DMVEMEEERLRMREHVMNEVD--TNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFT 343
V +E ++R +E + E + + E+ + E++ + + +Q+
Sbjct: 122 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 181
Query: 344 EEE--LKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKL 401
E+E ++E E + QE ++ ++ +++ +Q+E++Q+Q +Q+ Q+ + + +QM +++
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE 241
Query: 402 Q 402
Q
Sbjct: 242 Q 242
Score = 35.8 bits (81), Expect = 0.075
Identities = 27/122 (22%), Positives = 66/122 (54%), Gaps = 7/122 (5%)
Query: 283 EEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFF 342
E++ V +E ++R +E +V + ++ E + E++ + + + ++Q
Sbjct: 168 EQEGQVREQEGQVREQE---GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE 224
Query: 343 TEEELKEYENIIALQENELKKKADELQKQK--EELQRQHDQLEAQKLEYHQVIQQMEQKK 400
EE++++ E + QE +++K+ E Q QK E++++Q +Q+ Q+ + + +QM ++K
Sbjct: 225 QEEQMRKQEEQMGEQEEQVQKQ--EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK 282
Query: 401 LQ 402
Q
Sbjct: 283 EQ 284
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 66.2 bits (160), Expect = 5e-11
Identities = 70/345 (20%), Positives = 161/345 (46%), Gaps = 33/345 (9%)
Query: 76 QKAD--IEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQ 133
+KAD IEE+ R + L+L + + +ELK++ L+ ++ +I ++ +
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITN--EELKKKNA-ELQEKLRLAESEKSEIQLNVK 211
Query: 134 ALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKY---EMMKEHE--- 187
L ++ + L P +T + + + E K R +E K + E ++E E
Sbjct: 212 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 271
Query: 188 RREYLKTLNEEKR-KEEESKFEEMKKKHENHPKVNHPGSK--DQLKEVWEETDGLDPNDF 244
R + K +EKR +E+E + E +K+ K+ + +Q +++WE+ +
Sbjct: 272 REQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE------- 324
Query: 245 DPKTFFKLHDVNSDGFLDEQEL---EALFTKELEKVYDPKN---EEDDMVEMEEERLRMR 298
K+ + + E+ L E ++ +K+ D + E+D+ + +EER+R +
Sbjct: 325 ------KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 378
Query: 299 EHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQE 358
E + + + ++ E K E++E + + Q++ E+E KE++ ++
Sbjct: 379 EKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 438
Query: 359 NELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
E + +++Q+Q+E++ Q +++ Q+ + Q + Q+K+++
Sbjct: 439 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 483
Score = 64.3 bits (155), Expect = 2e-10
Identities = 72/364 (19%), Positives = 163/364 (44%), Gaps = 38/364 (10%)
Query: 66 ETDKHFREKLQKADIEEIK----SGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAK 121
E +K RE+ QK +E + RL ++ + + + E K QE R+R K
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401
Query: 122 LDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYE 181
+ + + + + KQ +++ +++ L L +K + +E K +E
Sbjct: 402 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP----EQKEKLWEQEKMQEQEEKIWE 457
Query: 182 MMKEHERREYL-----KTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEET 236
++ +E + K +EK +E+E + E ++K + + DQ + +WE+
Sbjct: 458 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW----DQEERMWEQD 513
Query: 237 DGLDPNDF----DPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEE 292
+ L + K + + + + EQE + +E + + E + + EE
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573
Query: 293 ERLRMREHVMNEVDTN----KDRLVTLEEFLKATEKK---------EFLEPDSWETLDQQ 339
E +R +E M E + ++++ EE ++ E+K E E D + ++
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633
Query: 340 QFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQK 399
+ EE+++E E + QE +++++ +++++Q+E++Q Q +++ Q+ + +Q E+K
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQE----EKMQGQEEK 689
Query: 400 KLQQ 403
+Q
Sbjct: 690 MREQ 693
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/227 (21%), Positives = 121/227 (53%), Gaps = 14/227 (6%)
Query: 170 DKTRHEE---FKKYEMMKEHERR----EYLKTLNEEKRKEEESKFEEMKKKHENHPKVNH 222
+K R +E +++ E M++ E++ E +E+ +E+E + E KK + K+
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Query: 223 PG-SKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPK 281
+++Q K+ W++ + + + + K+ + + + EQE + +E + + K
Sbjct: 539 EKKTQEQEKKTWDQEEKMREEERMREREKKMRE--EEEMMREQEEKMQEQEEKMREQEEK 596
Query: 282 N-EEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFL-KATEKKEFLEPDSWETLDQQ 339
E+++ ++ +EE++ +E M E + +D++ EE + + EK + E WE +++
Sbjct: 597 MWEQEEKMQEQEEKMWEQEEKMWEQE-EEDKMQEQEEMMWEQEEKMQEQEEKMWEQ-EEK 654
Query: 340 QFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQK 386
EE+++E E + QE +++++ +++Q Q+E+++ Q +++ Q+
Sbjct: 655 MREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701
Score = 59.7 bits (143), Expect = 5e-09
Identities = 49/244 (20%), Positives = 122/244 (50%), Gaps = 33/244 (13%)
Query: 171 KTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLK 230
KT+ +E K ++ ++ E ++ ++ R+EEE E+ +K E K+ ++Q +
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM-----REQEE 595
Query: 231 EVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEM 290
++WE+ + + + + EQE E ++ +E E D E+++M+
Sbjct: 596 KMWEQEEKMQEQEEK---------------MWEQE-EKMWEQEEE---DKMQEQEEMMWE 636
Query: 291 EEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEY 350
+EE+++ +E M E ++++ EE ++ E+K + + +++ EE+++E
Sbjct: 637 QEEKMQEQEEKMWE---QEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQ 693
Query: 351 ENIIALQENELKKKADELQKQKE------ELQRQHDQLEAQKLEYHQVIQQMEQKKLQQG 404
E + QE ++ + +++ Q+E E++ + +++ QK + + + + E++ +
Sbjct: 694 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPC 753
Query: 405 IPPS 408
+PPS
Sbjct: 754 LPPS 757
Score = 58.5 bits (140), Expect = 1e-08
Identities = 80/383 (20%), Positives = 173/383 (45%), Gaps = 55/383 (14%)
Query: 68 DKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQD 127
++ RE+ +K +E K R + L +R + ++++RQE RLR K + ++
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEK-RLREQEKELREQEKE 298
Query: 128 IGMDHQALLKQFDHLNHLNPDKFESTDL------------DMLIKAATSDLEHYDKTRHE 175
+ + + L +Q + + +E + + L + E K R +
Sbjct: 299 L-REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 357
Query: 176 EFKKYEM-----MKEHERREYLKTLNEEKRKEEESKFEEMKKK-HENHPKVNHPGSKDQL 229
E + +E KE RE K +E++ +EE + E +KK E + K Q
Sbjct: 358 EERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQK 417
Query: 230 KE--VWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKN----- 282
+E +WE+ + P+ KL + + EQE E ++ +E EK+ D +
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQKEKLWEQEK---MQEQE-EKIWEQE-EKIRDQEEMWGQE 472
Query: 283 ----------EEDDMVEMEEERLRMREHVMNEVDTNK----DRLVTLEEFLKATEK---- 324
E++D + +EE++R +E M + + +RL EE ++ +K
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQ 532
Query: 325 -KEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLE 383
++ E + +++ + EE+++E E + +E +++++ + +++Q+E++Q Q +++
Sbjct: 533 EEKMREEKKTQEQEKKTWDQEEKMREEERMRE-REKKMREEEEMMREQEEKMQEQEEKMR 591
Query: 384 AQK---LEYHQVIQQMEQKKLQQ 403
Q+ E + +Q+ E+K +Q
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQ 614
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 60.5 bits (145), Expect = 3e-09
Identities = 73/371 (19%), Positives = 176/371 (47%), Gaps = 31/371 (8%)
Query: 55 DEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRL 114
+E +Q + + ++ ++L++ EE + +L +E L + +L+R++ R
Sbjct: 344 EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR 403
Query: 115 RMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSD----LEHYD 170
++ + ++ + + L++ + + K E + +K + L+ +
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRR-EQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 171 KT-RHEEFKKYEMMK---EHERRE-YLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGS 225
+T RHE+ ++ + +K E ERRE +LK EE+R+++E + ++++++ E
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER-------- 514
Query: 226 KDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEE- 284
++Q + EE + L + + + + L +E + L + E+ + EE
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Query: 285 -DDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEF--LKATEKKEF-LEPDSWETLDQQQ 340
D +++ EEER + R + E + ++ + EE L+ E++E L+ + E +QQ
Sbjct: 575 RDQLLKREEERRQQR--LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 341 FFTEEELKEYENIIALQENELK-----KKADELQKQKEELQRQHDQLEAQKLEYHQVIQQ 395
EE +E +E + + K+ +E ++ ++ L+R+H++ E ++ E + Q+
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE-ERREQELAEEEQE 691
Query: 396 MEQKKLQQGIP 406
+++++ IP
Sbjct: 692 QARERIKSRIP 702
Score = 59.3 bits (142), Expect = 6e-09
Identities = 51/252 (20%), Positives = 116/252 (46%), Gaps = 19/252 (7%)
Query: 170 DKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQL 229
D+ + E+ +++E ++ + E +KR+E+E + E +++ E ++ + +
Sbjct: 112 DRRQEEDQRRFEP-RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRD 170
Query: 230 KEVW---EETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKEL------EKVYDP 280
+E+W +E + + + ++ F DE++L EL EK
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 281 KNEEDDMVEMEEER--------LRMREHVMNEVDTNKDR-LVTLEEFLKATEKKEFLEPD 331
+ +D + + EEE+ LR E + E + + R L EE L+ E++E
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 332 SWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQ 391
E QQ+ E++L+ + ++ E +++ E ++Q+EE + Q + E ++ Q
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350
Query: 392 VIQQMEQKKLQQ 403
+ ++ E+++ +Q
Sbjct: 351 LRREQEEERREQ 362
Score = 53.9 bits (128), Expect = 3e-07
Identities = 60/245 (24%), Positives = 114/245 (46%), Gaps = 21/245 (8%)
Query: 167 EHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSK 226
E +K R +E +K +E ++E + L EE+ K ++E +K + + +
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ-----EE 1030
Query: 227 DQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDD 286
+QL E L + + +L +E+E +ELE+ Y + E
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR--RQELERQYRKEEE--- 1085
Query: 287 MVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQ--QQFFTE 344
++ EEE+L +RE ++R EE L+ E++ E + +Q+ E
Sbjct: 1086 -LQQEEEQL-LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 345 EELKEYENIIALQENELKKKADELQKQ---KEELQRQHDQL---EAQKLEYHQVIQQMEQ 398
EE+++ E + +E E K++ EL++Q +EELQ++ +QL E +K + Q E+
Sbjct: 1144 EEVQQEEEQLLREEPE-KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 399 KKLQQ 403
++LQ+
Sbjct: 1203 EELQR 1207
Score = 50.8 bits (120), Expect = 2e-06
Identities = 79/350 (22%), Positives = 144/350 (41%), Gaps = 29/350 (8%)
Query: 72 REKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKR--QEVGRLRMLIKAKLDSLQDIG 129
RE+ K + EE + L +E + H + +LKR +E R R L + + +
Sbjct: 443 REQRLKREQEERRDW-LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 130 MDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMK--EHE 187
Q L ++ + + E + + L + R E+ K E K E E
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 188 RREY-LKTLNEEKR-----KEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDP 241
RRE LK EE+R +EEE + + +K++ E + +LK EE + L+
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEER-------LEQRLKR--EEVERLEQ 612
Query: 242 NDFDPKTFFKLH--DVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMRE 299
+ + + + L +E E ++L + + E+ E EEERL R
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL 672
Query: 300 HVMNEVDTNKDRLVTLE-----EFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENII 354
+E + + L E E +K+ K + +S Q + ++ +E +
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732
Query: 355 ALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQG 404
QE + +++ ELQ Q+EE + Q E Q+ ++ Q ++K ++G
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF--TWQWQAEEKSERG 780
Score = 50.1 bits (118), Expect = 4e-06
Identities = 65/329 (19%), Positives = 152/329 (46%), Gaps = 30/329 (9%)
Query: 56 EYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLR 115
+ L++ + L+ ++ + + Q+ + + + +L +E + + R K +R+ R
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 116 MLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHE 175
++ K + L +G + + +Q + ++ + + +L E +K R +
Sbjct: 964 KKLQQKEEQL--LGEEPEKRRRQEREKKYREEEELQQEEEQLL-------REEREKRRRQ 1014
Query: 176 EFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEE 235
E+++ K+ ++E + L EE+ K + +E ++++ ++ ++QL + EE
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKR---RLQERERQYREEEELQQ--EEEQL--LGEE 1067
Query: 236 TDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNE----EDDMVEME 291
+ + + + + K ++ +QE E L +E EK + E E++ ++ E
Sbjct: 1068 RETRRRQELE-RQYRKEEEL-------QQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119
Query: 292 EERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLD-QQQFFTEEELKEY 350
EE+L E + + EE + E+ EP+ + ++Q+ EEEL++
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 351 ENIIALQENELKKKADELQ-KQKEELQRQ 378
E + +E E +++ E Q +++EELQRQ
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQ 1208
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/267 (22%), Positives = 120/267 (44%), Gaps = 41/267 (15%)
Query: 167 EHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSK 226
E + R E K+ +E + RE E+ ++EEE E ++K +
Sbjct: 909 EEEELQREEREKRRRQEQERQYRE-----EEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 227 DQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEK----VYDPKN 282
+L++ E+ G +P + K + + +QE E L +E EK ++ +
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL---QQEEEQLLREEREKRRRQEWERQY 1020
Query: 283 EEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQ--- 339
+ D ++ EEE+L E + ++R EE L+ +++E L + ET +Q
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQ-ERERQYREEEELQ--QEEEQLLGEERETRRRQELE 1077
Query: 340 -QFFTEEELKEYENIIALQENELKKKAD---------ELQKQKE-------------ELQ 376
Q+ EEEL++ E + +E E +++ + ELQ+++E EL+
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE 1137
Query: 377 RQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
RQ+ + E + E Q++++ +K+ +Q
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Score = 49.3 bits (116), Expect = 7e-06
Identities = 62/270 (22%), Positives = 123/270 (45%), Gaps = 44/270 (16%)
Query: 175 EEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWE 234
E+ ++ +E ++RE EE++++ + E +K+ + + +++ +++ E
Sbjct: 792 EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Query: 235 ETDGLDPND---------FDPKTFFKL--------HDVNSDGFLDEQ----------ELE 267
E DGL + D K ++L H + + L EQ E E
Sbjct: 852 EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911
Query: 268 ALFTKELEKVYDPKNE----EDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATE 323
L +E EK + E E++ ++ EEE+L E E ++R + K +
Sbjct: 912 ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREE---REKRRRQERERQYRKDKKLQQ 968
Query: 324 KKEFL---EPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQ---KEELQR 377
K+E L EP+ ++++ + EEE + E L+E K++ E ++Q K+ELQ+
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 378 QHDQLEAQKLEYHQV----IQQMEQKKLQQ 403
+ +QL ++ E ++ Q E+++LQQ
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQ 1058
Score = 46.6 bits (109), Expect = 4e-05
Identities = 67/357 (18%), Positives = 153/357 (42%), Gaps = 25/357 (7%)
Query: 65 LETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDS 124
L+ ++ R + ++ + + + + +E +S R + + Q+V R K +
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452
Query: 125 LQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMK 184
Q H+ ++ L + + D L ++ R +F++ E+
Sbjct: 1453 QQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR--KFREQELRS 1510
Query: 185 EHERREYLKTLNEEKRKEEESKF----EEMKKKHENHPKVNHPGSK----DQLKEVWEET 236
+ R++L+ + R++ + KF ++++++ + K +QL++ EE
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570
Query: 237 DGLDPNDFDPKTFFKLHDVNSDG-----FLDEQELEALF-TKELEKVYDPKNEEDDMV-- 288
L + D K + V DEQ+L ++L + D K ED+ +
Sbjct: 1571 Q-LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629
Query: 289 EMEEERLRMREHVMNEVDTNKD-RLVTLEEFLKATEKKEFLEPDSW-ETLDQQQFFTEEE 346
E EE++L +E ++ R E+ L+ ++F E + + ++QQ +E
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 347 LKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
+++ +E +L+++ E + +EE Q + +LE + E Q+ Q+ EQ++L++
Sbjct: 1690 DRKFRE----EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742
Score = 45.1 bits (105), Expect = 1e-04
Identities = 63/343 (18%), Positives = 144/343 (41%), Gaps = 38/343 (11%)
Query: 66 ETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSL 125
E + R+K Q+ + E + S++ + + R + DE E+ R R +
Sbjct: 132 EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDE----ELWRQRQ----EWQER 183
Query: 126 QDIGMDHQALLKQFDHLNHLNPDK--FESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMM 183
++ + + L H PD+ +L L + + + + R + + E
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 184 KEHERREYLKTLNEEKRKEEE-SKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPN 242
KE +RE + EEK +EEE + E++++ E K+ + + +E ++ L
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL--- 300
Query: 243 DFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVM 302
EQ+L +E + + + E+ + E +EE R + +
Sbjct: 301 ------------------RREQQLRRKQEEERREQQEERREQQERREQQEE--RREQQLR 340
Query: 303 NEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQE--NE 360
E + +++ + E+ + +++ L + E +QQ E++L+ + + Q+ E
Sbjct: 341 REQEERREQQLRREQ--EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398
Query: 361 LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
+ + ++ +++++L+R+ Q+L Q ++ EQK Q+
Sbjct: 399 QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Score = 45.1 bits (105), Expect = 1e-04
Identities = 75/359 (20%), Positives = 151/359 (42%), Gaps = 56/359 (15%)
Query: 66 ETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSL 125
+ D+ FRE+ E+++ R ++L S R + L+ Q+V R K D
Sbjct: 1552 DRDRKFREE------EQLRQEREEQQL---SRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 126 QDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKE 185
Q + Q L+Q D+ D +L + L ++ R + ++ ++
Sbjct: 1603 QLRRQEGQQQLRQ-------ERDRKFREDEQLLQEREEQQLHRQERDR-KFLEEEPQLRR 1654
Query: 186 HERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFD 245
ER + L+ + K +EEE +E +++ +++ ++ EE L + +
Sbjct: 1655 QEREQQLRHDRDRKFREEEQLLQEGEEQQLRR--------QERDRKFREEEQQLRRQERE 1706
Query: 246 PKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVE-----MEEERLRMREH 300
K + + L QELE F +E + + + E+ E +EEE+LR
Sbjct: 1707 RKF------LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 301 VMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKE--YENIIALQE 358
+DR EE L+ +++ L ++F EE+L++ E + Q+
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQE----SDRKFREEEQLRQEREEQQLRPQQ 1816
Query: 359 NELKKKADE----LQKQKEELQRQHDQ----------LEAQKLEYHQVIQQMEQKKLQQ 403
+ K + +E L++Q++ L+++ D+ E + E ++ Q+ EQK+ Q+
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQE 1875
Score = 43.9 bits (102), Expect = 3e-04
Identities = 55/274 (20%), Positives = 112/274 (40%), Gaps = 46/274 (16%)
Query: 142 LNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRK 201
L H KF + +L + L ++ R ++ ++ ++ R++L+ + +R+
Sbjct: 1661 LRHDRDRKFREEE-QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 202 EEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFL 261
E E KF E ++ + ++QL+ L+ P
Sbjct: 1720 ELERKFREEEQLRQET-------EQEQLRRQERYRKILEEEQLRP--------------- 1757
Query: 262 DEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKA 321
E+E + L +E ++ + + EE E EE++LR +E DR EE L+
Sbjct: 1758 -EREEQQLRRQERDRKF--REEEQLRQEREEQQLRSQE---------SDRKFREEEQLRQ 1805
Query: 322 TEKKEFLEPDS------WETL-----DQQQFFTEEELKEYENIIALQENELKKKADELQK 370
+++ L P WE +Q+Q +E ++Y E ++ ++
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELW 1865
Query: 371 QKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQG 404
Q+EE +R+ ++ + E+ + Q+ EQ+ Q G
Sbjct: 1866 QEEEQKRRQERERKLREEHIRRQQKEEQRHRQVG 1899
Score = 43.1 bits (100), Expect = 5e-04
Identities = 49/244 (20%), Positives = 108/244 (44%), Gaps = 32/244 (13%)
Query: 167 EHYDKTRHEEFKKYEMMKEH---ERREYLKTLNEEKRKEEESKF--EEMKKKHENHPKVN 221
E +K R +E ++ +E E + L+ E++R+E E ++ EE ++ + +
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 222 HPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQEL-EALFTKELEKVYDP 280
+ LK WE + D K + K + L++ +L + ++L+ +
Sbjct: 1216 DEDQRSDLKWQWEPEK--ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273
Query: 281 KNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQ 340
+ E D E+ER R ++ +DR EE L+ E+KE D ++ +++Q
Sbjct: 1274 QQERD----REQERRRWQQ---------RDRHFPEEEQLEREEQKEAKRRDR-KSQEEKQ 1319
Query: 341 FFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK 400
EE +E +++ D +++E+L ++ ++ ++ E + ++ E +
Sbjct: 1320 LLREER----------EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH 1369
Query: 401 LQQG 404
+QG
Sbjct: 1370 QEQG 1373
Score = 42.0 bits (97), Expect = 0.001
Identities = 54/276 (19%), Positives = 113/276 (40%), Gaps = 29/276 (10%)
Query: 154 DLDMLIKAATSDLEHYD-----KTRHEEFKKYEMMKEH-------ERREYLKTLNEEKRK 201
D + + + DL+H + R +E ++++ H ER E + +++
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314
Query: 202 EEESKF-----EEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVN 256
+EE + EE +++ E K + L+E E+ D + H
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFRE--EEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 257 SDGFLDE------QELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKD 310
FL+E QE E F KE E+ + E + + + + R E ++ + ++
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKE-EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 311 RLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEE---LKEYENIIALQENELKKKADE 367
++ + +++FLE + ++ + F EEE + E + QE + K +E
Sbjct: 1432 FREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491
Query: 368 LQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
Q +++E R+ + E + E + + EQ+ +Q
Sbjct: 1492 QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 59.7 bits (143), Expect = 5e-09
Identities = 86/378 (22%), Positives = 166/378 (43%), Gaps = 52/378 (13%)
Query: 56 EYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKR-QEVGRL 114
E L+ +D +E + K++K ++ RLSK+++++ + + + L+ Q + +
Sbjct: 477 EELRTTVDSVEGNASKILKMEK------ENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 530
Query: 115 RMLIKAKLD-SLQDIGMDHQALLKQFDHLN-HLNPDKFESTDLDML-IKAATSDLEHYDK 171
M KA+L+ +++ + + + +K + N HLN + +A D+E +K
Sbjct: 531 LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590
Query: 172 TRHEEFKKYEMMK---EHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKD- 227
HE K+ E E+R+ K L K K E + EE++ + + K N K
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA--EELENELHHLEKENELLQKKI 648
Query: 228 -QLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDD 286
LK E+ + L+ NS+ + ++L+ + ++ E +
Sbjct: 649 TNLKITCEKIEALEQE-------------NSELERENRKLKKTLDSFKNLTFQLESLEKE 695
Query: 287 MVEMEEERLRMREHVMN----------------EVDTNKDRLVTLEEFLKATEKKEFLEP 330
+++EE L +R +V + E+++ K++L E LKA+ KK
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755
Query: 331 DSWETLDQQQFFTEEELKEYENIIALQENELKKKADE---LQKQKEELQ---RQHDQLEA 384
S++ LD + ++ L+ I E+EL+ E LQK EEL+ ++ +QLE
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEK 815
Query: 385 QKLEYHQVIQQMEQKKLQ 402
+ Q Q+E+ K Q
Sbjct: 816 ENKSLEQETSQLEKDKKQ 833
Score = 38.5 bits (88), Expect = 0.012
Identities = 84/377 (22%), Positives = 148/377 (39%), Gaps = 55/377 (14%)
Query: 58 LKQVIDVLETDKHFREK-----LQKADIEE-------IKSGRLSKELDLVSHHVR----- 100
L+Q LE DK EK Q+A+I++ +K G L KE +S +
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 101 -TKLDELKRQE---VGRLRMLIKAKLDSLQDIGMDH---QALLKQFDHLNH------LNP 147
+L EL+++ V R + IK + +D+ + Q + + L H LN
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 148 DKF----ESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEE 203
++ +STD D K S LE K + E K+ ++ R E N++ R+E
Sbjct: 940 ERLLHDEQSTD-DSRYKLLESKLESTLK-KSLEIKEEKIAALEARLEESTNYNQQLRQEL 997
Query: 204 ES---KFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGF 260
++ +E +K++ + V WE + K +L +V +
Sbjct: 998 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL-LKVKDRLIEVERNNA 1056
Query: 261 LDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLK 320
+ E +AL T+ + N + ++ ++ + + ++E N K
Sbjct: 1057 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA----------K 1106
Query: 321 ATEKKEFLEPDSWETLDQQ-QFFTEEELKEYENIIALQENE-LKKKADELQKQKEELQRQ 378
+ L S ++Q Q ++ E EN ++E E LK D L K E+L+
Sbjct: 1107 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL 1166
Query: 379 HDQLEAQKLEYHQVIQQ 395
H E Q EY +I +
Sbjct: 1167 H---ERQASEYESLISK 1180
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/254 (20%), Positives = 112/254 (44%), Gaps = 21/254 (8%)
Query: 131 DHQALLKQFDHLNHLNPDKFESTD-LDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERR 189
++++++K+ + L L + + L++L + S+ E ++H K E E R
Sbjct: 1138 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI-SKHGTLKSAHKNLEVEHR 1196
Query: 190 E----YLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFD 245
+ Y + L ++ + E+ K +++++ NH + K++ E D L+
Sbjct: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN----- 1251
Query: 246 PKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEV 305
T+ +L L E E+ K L+ + + E +E E +L+ + ++
Sbjct: 1252 -HTYSQL--------LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1302
Query: 306 DTNKDRLVTLEEFLKATEKKEFLEP-DSWETLDQQQFFTEEELKEYENIIALQENELKKK 364
T + L LK ++E D +TL Q E+ E +++ +++ + K
Sbjct: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1362
Query: 365 ADELQKQKEELQRQ 378
+EL++QKE+L+ +
Sbjct: 1363 LNELRRQKEKLEEK 1376
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 59.7 bits (143), Expect = 5e-09
Identities = 86/378 (22%), Positives = 166/378 (43%), Gaps = 52/378 (13%)
Query: 56 EYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKR-QEVGRL 114
E L+ +D +E + K++K ++ RLSK+++++ + + + L+ Q + +
Sbjct: 477 EELRTTVDSVEGNASKILKMEK------ENQRLSKKVEILENEIVQEKQSLQNCQNLSKD 530
Query: 115 RMLIKAKLD-SLQDIGMDHQALLKQFDHLN-HLNPDKFESTDLDML-IKAATSDLEHYDK 171
M KA+L+ +++ + + + +K + N HLN + +A D+E +K
Sbjct: 531 LMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENK 590
Query: 172 TRHEEFKKYEMMK---EHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKD- 227
HE K+ E E+R+ K L K K E + EE++ + + K N K
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA--EELENELHHLEKENELLQKKI 648
Query: 228 -QLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDD 286
LK E+ + L+ NS+ + ++L+ + ++ E +
Sbjct: 649 TNLKITCEKIEALEQE-------------NSELERENRKLKKTLDSFKNLTFQLESLEKE 695
Query: 287 MVEMEEERLRMREHVMN----------------EVDTNKDRLVTLEEFLKATEKKEFLEP 330
+++EE L +R +V + E+++ K++L E LKA+ KK
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755
Query: 331 DSWETLDQQQFFTEEELKEYENIIALQENELKKKADE---LQKQKEELQ---RQHDQLEA 384
S++ LD + ++ L+ I E+EL+ E LQK EEL+ ++ +QLE
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEK 815
Query: 385 QKLEYHQVIQQMEQKKLQ 402
+ Q Q+E+ K Q
Sbjct: 816 ENKSLEQETSQLEKDKKQ 833
Score = 39.3 bits (90), Expect = 0.007
Identities = 82/382 (21%), Positives = 158/382 (41%), Gaps = 66/382 (17%)
Query: 58 LKQVIDVLETDKHFREK-----LQKADIEE-------IKSGRLSKELDLVSHHVRTKLDE 105
L+Q LE DK EK Q+A+I++ +K G L KE +S +
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG----- 874
Query: 106 LKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSD 165
+ ++ RL+ L K + ++ +D + L+ + L +K ++ ++ ++ T +
Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS---EKLKTQQMNNDLEKLTHE 931
Query: 166 LE----------HYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHE 215
LE H +++ + +K E E ++ L+ + EEK E++ EE ++
Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLE-IKEEKIAALEARLEESTNYNQ 990
Query: 216 NHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELE 275
+ +LK V + + L + + ++ + E+E + T+EL
Sbjct: 991 Q--------LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET-TRELL 1041
Query: 276 KVYDPKNE-EDDMVEMEEERLRMREHVMNEVDTNKDRL-----------VTLEEF----- 318
KV D E E + ++ E+ ++ + +++T + L V+L+E
Sbjct: 1042 KVKDRLIEVERNNATLQAEKQALKTQ-LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1100
Query: 319 ---LKATEKKEFLEPDSWETLDQQ-QFFTEEELKEYENIIALQENE-LKKKADELQKQKE 373
K + L S ++Q Q ++ E EN ++E E LK D L K E
Sbjct: 1101 TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE 1160
Query: 374 ELQRQHDQLEAQKLEYHQVIQQ 395
+L+ H E Q EY +I +
Sbjct: 1161 KLELLH---ERQASEYESLISK 1179
Score = 37.0 bits (84), Expect = 0.034
Identities = 51/254 (20%), Positives = 112/254 (44%), Gaps = 21/254 (8%)
Query: 131 DHQALLKQFDHLNHLNPDKFESTD-LDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERR 189
++++++K+ + L L + + L++L + S+ E ++H K E E R
Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI-SKHGTLKSAHKNLEVEHR 1195
Query: 190 E----YLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFD 245
+ Y + L ++ + E+ K +++++ NH + K++ E D L+
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN----- 1250
Query: 246 PKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEV 305
T+ +L L E E+ K L+ + + E +E E +L+ + ++
Sbjct: 1251 -HTYSQL--------LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1301
Query: 306 DTNKDRLVTLEEFLKATEKKEFLEP-DSWETLDQQQFFTEEELKEYENIIALQENELKKK 364
T + L LK ++E D +TL Q E+ E +++ +++ + K
Sbjct: 1302 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1361
Query: 365 ADELQKQKEELQRQ 378
+EL++QKE+L+ +
Sbjct: 1362 LNELRRQKEKLEEK 1375
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 58.2 bits (139), Expect = 1e-08
Identities = 89/355 (25%), Positives = 156/355 (43%), Gaps = 67/355 (18%)
Query: 72 REKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQ-DIGM 130
R+ +K DI + RL +EL S+ ++ E ++Q++ R L+ + ++++ + G
Sbjct: 1936 RQIQEKTDIID----RLEQELLCASNRLQEL--EAEQQQIQEERELLSRQKEAMKAEAGP 1989
Query: 131 DHQALLKQFDHLNHLNPDKFE--------STDLDMLIKAATSDLEHYDKT--RHEEFKKY 180
Q LL++ + L +K E DL +KA D+E E+ K
Sbjct: 1990 VEQQLLQETEKLMK---EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNT 2046
Query: 181 EMMKEHERREYLKTLNEEKRK----------EEESKFEEMKKKHENHPKVN---HPGSKD 227
E+M ++ + L+ E+ RK E F++ +K E KV P S+
Sbjct: 2047 ELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEH 2106
Query: 228 QLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKE-LEKVYDPKNEEDD 286
Q +EV + N KT ++ E L +KE L++ +NEE
Sbjct: 2107 QTREVEQLA-----NHLKEKT--------------DKCSELLLSKEQLQRDIQERNEE-- 2145
Query: 287 MVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEF--LEPDSWETLDQQQFFTE 344
+E E R+R E + LV+ + F K ++K F +E +L+ Q
Sbjct: 2146 -IEKLEFRVRELEQAL---------LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAER 2195
Query: 345 EELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQK 399
+ + E I E +L++ +EL+ + EE+Q+ H QLE QK E +Q++EQ+
Sbjct: 2196 DAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2250
Score = 48.9 bits (115), Expect = 9e-06
Identities = 88/449 (19%), Positives = 175/449 (38%), Gaps = 74/449 (16%)
Query: 19 LTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKA 78
L + + ++ D+ K+ N+ + I+ DT E LK+ + ++ +K ++ +
Sbjct: 475 LRSYSNITVNEDQIKLMNV-AINELNIKLQDTNSQ-KEKLKEELGLILEEKCALQRQLED 532
Query: 79 DIEEIKSGR--LSKELDLVSHHVRTKLDELKRQ--EVGRLRMLIKAKLDSLQDIGMDHQA 134
+EE+ R + + ++ +KL+E + V L+ I + +S +++ + H+A
Sbjct: 533 LVEELSFSREQIQRARQTIAEQ-ESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEA 591
Query: 135 LLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKT 194
+ + L+ML K + L+ +++ E ++ E L
Sbjct: 592 EVTNY------------KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 639
Query: 195 LNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKT-----F 249
L E+ E E++K H K G ++++ + E N +
Sbjct: 640 LKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEI 699
Query: 250 FKLHDVNSDGFLDEQELEALFTKELEK---VYDPKNEEDDMVEMEEERLRMR----EHVM 302
KL D+ + E L EL+K + + +E +E E + L+++ E M
Sbjct: 700 SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQM 759
Query: 303 NEVDTN---------------KDRLVTLEEFLK----ATEKKEFLEPDS---------WE 334
E + + KD TLE+ LK ++++ + DS WE
Sbjct: 760 KEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819
Query: 335 T-----------LDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLE 383
L QQ EE+++ N + E + ELQ++ L + D LE
Sbjct: 820 KEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE 879
Query: 384 ----AQKLEYHQVIQQMEQKKLQQGIPPS 408
Q+LEY ++ + ++ Q I P+
Sbjct: 880 DSKNKQELEYKSKLKALNEELHLQRINPT 908
Score = 43.1 bits (100), Expect = 5e-04
Identities = 68/313 (21%), Positives = 128/313 (40%), Gaps = 34/313 (10%)
Query: 107 KRQEVGRLRMLIKAKLDSLQDIG----MDHQALLKQFDHLNHLNPDKFESTDLDMLIKAA 162
+ +E+ +L +I+ L +IG M+ +L ++ D L H LD++I A
Sbjct: 2345 REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKH---------QLDVVI-AE 2394
Query: 163 TSDLEHYDKTRHEE--FKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKV 220
LE +T +EE F K ++KE + T K E E+++ EN V
Sbjct: 2395 KLALEQQVETANEEMTFMK-NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2453
Query: 221 --NHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVY 278
+H EV D L + +T+FK + N G + E L +LE
Sbjct: 2454 AIDHLSKDKPELEVVLTEDAL--KSLENQTYFKSFEENGKGSIINLETRLL---QLESTV 2508
Query: 279 DPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETL-- 336
K+ E + + ++ M+E E + + ++V L++ ++ + E +
Sbjct: 2509 SAKDLE--LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQE 2566
Query: 337 ------DQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYH 390
D Q +E E +N+ L+E+EL L + EL+ Q ++ +
Sbjct: 2567 YAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEK 2626
Query: 391 QVIQQMEQKKLQQ 403
+ ++ E+ L++
Sbjct: 2627 EQVEIAEKNVLEK 2639
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/164 (26%), Positives = 83/164 (50%), Gaps = 30/164 (18%)
Query: 266 LEALFTKELEKVYDPKNEEDDMVE-MEEERLRMREHVMNEVDTN-----------KDRLV 313
++ F +E KVY+ E+D VE +E ++ +E ++ E++T KD+L
Sbjct: 296 MQISFLQEKIKVYEM--EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLT 353
Query: 314 TLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQE-----NELKKK---- 364
T ++ L E +E + + E + + T + KE ++ +++ EL+K+
Sbjct: 354 TADKLLG--ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKD 411
Query: 365 ----ADELQKQKEELQRQHDQLEAQKLE-YHQVIQQMEQKKLQQ 403
D +Q+ ++E QR+ +QL A+ E Y Q I QM+Q+ ++Q
Sbjct: 412 SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQ 455
Score = 40.8 bits (94), Expect = 0.002
Identities = 84/369 (22%), Positives = 162/369 (43%), Gaps = 62/369 (16%)
Query: 66 ETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSL 125
E++K +E L+ +I++ +S L +++L S ++ + EL+ Q + +M++ L
Sbjct: 3113 ESEKPSQELLEY-NIQQKQSQMLEMQVELSS--MKDRATELQEQ-LSSEKMVVAELKSEL 3168
Query: 126 QDIGMDHQALLK-QFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMK 184
++ + LK Q HL L + E +K T ++ + T E KK ++
Sbjct: 3169 AQTKLELETTLKAQHKHLKELEAFRLE-------VKDKTDEVHLLNDTLASEQKKSRELQ 3221
Query: 185 EHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDF 244
+E K E+R +EE E++K E+ + N QL + E+ L N+
Sbjct: 3222 WALEKEKAKLGRSEERDKEE--LEDLKFSLESQKQRNL-----QLNLLLEQQKQL-LNES 3273
Query: 245 DPKTFFKLHDVNSDGFLDEQ-----------ELEALFTKELEKVYDPKNEEDDMVEMEEE 293
K + + D L E+ E E + +E+ D + E ++ +
Sbjct: 3274 QQK--IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331
Query: 294 RLRMREHVMNEVDTNKDRLVTLEE-------FLKATEKKEFLEPDSWETLDQQQFFTEEE 346
+ R + +E D K+ LEE L TEK + DS +T Q E++
Sbjct: 3332 TGQSRPPLPSE-DLLKELQKQLEEKHSRIVELLNETEKYKL---DSLQTRQQM----EKD 3383
Query: 347 LKEYENIIALQEN---ELKKKADELQKQKEELQRQHDQ---------LEAQKLEYHQVIQ 394
+ + + ++ E +KK ELQ + E+LQRQ ++ LE Q+L+ ++Q
Sbjct: 3384 RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ--GIMQ 3441
Query: 395 QMEQKKLQQ 403
+ ++++L++
Sbjct: 3442 EFQKQELER 3450
Score = 38.9 bits (89), Expect = 0.009
Identities = 75/345 (21%), Positives = 144/345 (41%), Gaps = 42/345 (12%)
Query: 75 LQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIG--MDH 132
LQ+A E+ ++ R EL S ++ + +L+ E R D LQ + H
Sbjct: 214 LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTH 273
Query: 133 QALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYL 192
Q L++ DHL L + + D M I E+ K YEM E+ + +
Sbjct: 274 QQQLEEQDHL--LEDYQKKKEDFTMQISFL-----------QEKIKVYEM----EQDKKV 316
Query: 193 KTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQL----KEVWEETDGLDPNDFDPKT 248
+ N+E+ +E+E+ EE+ K K KD+L K + E + + + + K
Sbjct: 317 ENSNKEEIQEKETIIEELNTKIIEEEKKTLE-LKDKLTTADKLLGELQEQIVQKNQEIKN 375
Query: 249 F-FKLHDVNSDGFLDEQELEALF--TKELEK--VYDPKNEEDDMVEMEEERLRMREHVMN 303
+L + +E++ L +EL+K D + E D + ME+E R E +
Sbjct: 376 MKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRA 435
Query: 304 EVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQE----- 358
E+D + + + + ++ + + +T + + E L+ Y NI ++
Sbjct: 436 ELDEMYGQQIV--QMKQELIRQHMAQMEEMKTRHKGEM--ENALRSYSNITVNEDQIKLM 491
Query: 359 ----NELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQK 399
NEL K + QKE+L+ + + +K + ++ + ++
Sbjct: 492 NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE 536
Score = 35.0 bits (79), Expect = 0.13
Identities = 55/231 (23%), Positives = 95/231 (41%), Gaps = 44/231 (19%)
Query: 181 EMMKEHERREYLKTLNEEKRKE----EESKFEEMKKKHENHPKVNHPGSKDQLKEVWEET 236
E + E RE L E + E E+ +E +K + +V K + ++ ++
Sbjct: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR-DDLQKQV 2023
Query: 237 DGLDPN-DFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERL 295
L+ + + F +L + +D ++ K+LEK M + +E+
Sbjct: 2024 KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK----------MRKFLDEQA 2073
Query: 296 RMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIA 355
REH E D + + LE+ LK + Q +E + +E E +
Sbjct: 2074 IDREH---ERDVFQQEIQKLEQQLKVVPRF--------------QPISEHQTREVEQLA- 2115
Query: 356 LQENELKKKAD---ELQKQKEELQR--QHDQLEAQKLEYHQVIQQMEQKKL 401
N LK+K D EL KE+LQR Q E +KLE+ ++++EQ L
Sbjct: 2116 ---NHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFR--VRELEQALL 2161
Score = 35.0 bits (79), Expect = 0.13
Identities = 68/319 (21%), Positives = 131/319 (41%), Gaps = 57/319 (17%)
Query: 66 ETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSL 125
ET+K +EKL+ E L K++ + V ++V R L + K L
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE--------EQVSRFIELEQEKNTEL 2048
Query: 126 QDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKE 185
D+ +QAL KQ + + KF + D EH +E +K E +
Sbjct: 2049 MDLRQQNQALEKQLEKMR-----KF--------LDEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 186 HERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQL-KEVWEETDGLDPNDF 244
R + ++E + +E E +K+K + ++ SK+QL +++ E + ++ +F
Sbjct: 2096 VVPR--FQPISEHQTREVEQLANHLKEKTDKCSELLL--SKEQLQRDIQERNEEIEKLEF 2151
Query: 245 DPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNE 304
+ + V++D F ++ + E K E V+++ ER +
Sbjct: 2152 RVRELEQALLVSADTFQKVEDRKHFGAVEA------KPELSLEVQLQAER--------DA 2197
Query: 305 VDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKK 364
+D + + LEE L+ + +E LE + E QQ + E+++ K+
Sbjct: 2198 IDRKEKEITNLEEQLE--QFREELENKNEEV---QQLHMQLEIQK------------KES 2240
Query: 365 ADELQKQKEELQRQHDQLE 383
LQ+ ++E + D +E
Sbjct: 2241 TTRLQELEQENKLFKDDME 2259
Score = 34.3 bits (77), Expect = 0.22
Identities = 78/405 (19%), Positives = 158/405 (39%), Gaps = 63/405 (15%)
Query: 50 TGLYYDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQ 109
T L +++Q+ E + +E++++ + + + + E +LVS R L+EL+
Sbjct: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVLLEELEAL 1663
Query: 110 E----VGRLRMLIKAKLDSLQ-DIGMDHQALL-------KQFDHLNHLNPDKFESTDLDM 157
+ GR ++ + + S Q G ++Q + K+ D P + S +
Sbjct: 1664 KQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYA 1723
Query: 158 LIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEE------SKFEEMK 211
L KA L K E K ++E R L L+ + + S+ E
Sbjct: 1724 LQKANNRLL----KILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779
Query: 212 KK--HENHPKV------NHPGSKDQLKEV--WEET-------------DGLDPNDFDPKT 248
K HE H +V ++ GS ++ W + G + DP+
Sbjct: 1780 KSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839
Query: 249 FFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDD----MVEMEEERLRMREHVMNE 304
+ +++S L+A K LE + + ++ + E+ E R ++
Sbjct: 1840 EELMLNISS-------RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATES 1892
Query: 305 VDTNKDRLVTLEEFLKATEKKEFLEPDSWETLD---QQQFFTEEELKEYENIIALQENEL 361
+ ++ L E +A E+ + +D ++ E +++E +II E EL
Sbjct: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952
Query: 362 ---KKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
+ EL+ +++++Q + + L QK +EQ+ LQ+
Sbjct: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE 1997
Score = 32.0 bits (71), Expect = 1.1
Identities = 65/327 (19%), Positives = 139/327 (42%), Gaps = 29/327 (8%)
Query: 58 LKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRML 117
++++ L+ ++ +LQ +D L E DL+ ++ +L+E + V L
Sbjct: 3309 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE-DLLKE-LQKQLEEKHSRIVELLNET 3366
Query: 118 IKAKLDSLQ---DIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRH 174
K KLDSLQ + D Q H L ++ +T+ + S +E D R
Sbjct: 3367 EKYKLDSLQTRQQMEKDRQV------HRKTLQTEQEANTEGQKKMHELQSKVE--DLQRQ 3418
Query: 175 EEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPG----SKDQLK 230
E K+ ++ K + L+ + +E +K+E + E+ + + + +N P + D+ +
Sbjct: 3419 LEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTR 3478
Query: 231 EVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEM 290
W ++ + + KL ++N G ELE + +K+ ++ + +
Sbjct: 3479 N-WVLQQKIE-GETKESNYAKLIEMNGGGTGCNHELEMI----RQKLQCVASKLQVLPQK 3532
Query: 291 EEERLRMR---EHVMNEVDTNKDRLVTLEEFLKATEKKE--FLEPD-SWETLDQQQFFTE 344
ERL+ + V N D ++ + L + +E + P S +L ++
Sbjct: 3533 ASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQN 3592
Query: 345 EELKEYENIIALQENELKKKADELQKQ 371
EL + + + ++N+L+ +L++Q
Sbjct: 3593 AELTGHISQLTEEKNDLRNMVMKLEEQ 3619
Score = 30.4 bits (67), Expect = 3.1
Identities = 42/160 (26%), Positives = 69/160 (43%), Gaps = 25/160 (15%)
Query: 263 EQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMN-EVDTNKDRLVT------- 314
EQE E + LE Y+ + ++ M+EM+ E M++ + + +++V
Sbjct: 3111 EQESEKPSQELLE--YNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSEL 3168
Query: 315 ------LEEFLKATEKK-EFLEPDSWETLDQ-------QQFFTEEELKEYENIIALQENE 360
LE LKA K + LE E D+ E+ K E AL++ +
Sbjct: 3169 AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEK 3228
Query: 361 LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK 400
K E ++ KEEL+ LE+QK Q+ +EQ+K
Sbjct: 3229 AKLGRSE-ERDKEELEDLKFSLESQKQRNLQLNLLLEQQK 3267
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 57.8 bits (138), Expect = 2e-08
Identities = 88/368 (23%), Positives = 164/368 (44%), Gaps = 37/368 (10%)
Query: 56 EYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELD---LVSHHVRTKLDELKRQEVG 112
E K ++ +ET+ ++ ++EE++S ++KE D V ++ + D+LK
Sbjct: 1654 ETQKLNLENIETENIRLTQILHENLEEMRS--VTKERDDLRSVEETLKVERDQLKEN--- 1708
Query: 113 RLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHY-DK 171
LR I L+ +++ + H L + + ++ L E T+ I DLEH D
Sbjct: 1709 -LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNE---ISNMQKDLEHSNDA 1764
Query: 172 TRHEEFKKYEMMK--EHERREYLKTLNEEKR--KEEESKFEEMKKKHEN-HPKVNHPGSK 226
+ ++ K E ++ +E +T+++ + E+ K M+K EN + K+ +
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824
Query: 227 DQLKEVWEETDGLDPNDFDPKTF----FKLHDVNSDGFLDEQELEAL-----FTKELEKV 277
+ E T D N+ K K + L + E+E L + LE++
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM 1884
Query: 278 YDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLD 337
E D++ +EE R+ + + K R + +++ LK L + ET+D
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR---MLSKEHKETVD 1941
Query: 338 QQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEY---HQVIQ 394
+ + E++ E I+ + +L K DELQK+ +ELQ++ QL K + H+ I
Sbjct: 1942 KLR----EKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN 1997
Query: 395 QMEQKKLQ 402
+MEQ K Q
Sbjct: 1998 EMEQLKKQ 2005
Score = 52.8 bits (125), Expect = 6e-07
Identities = 59/261 (22%), Positives = 108/261 (41%), Gaps = 31/261 (11%)
Query: 170 DKTRHEEFKKYEMMK-EHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQ 228
+K++ + K+ +++ + E E K +NE + + E K +E+ +H ++ +
Sbjct: 1131 EKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLE---LAQK 1187
Query: 229 LKEVWEETDGLDPNDFDPKTFFKLHDVNSD---GFLDEQELEALFTKELEKV--YDPKNE 283
L E +EE + K K + D G++ E E L TKE K+ K
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247
Query: 284 EDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLE-----PDSWETLDQ 338
++ + E+ ++N D K EE E++E L ++ ET+++
Sbjct: 1248 QETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE 1307
Query: 339 QQFFTEEELKEYENIIALQENE-----------------LKKKADELQKQKEELQRQHDQ 381
+ TE+ + +A E E L K+ D L+ KE L+ +HDQ
Sbjct: 1308 LELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQ 1367
Query: 382 LEAQKLEYHQVIQQMEQKKLQ 402
L+ E IQ+ + K+ Q
Sbjct: 1368 LKEHIRETLAKIQESQSKQEQ 1388
Score = 47.4 bits (111), Expect = 2e-05
Identities = 88/373 (23%), Positives = 160/373 (42%), Gaps = 65/373 (17%)
Query: 58 LKQVIDVLETDK-HFREKLQKADIEEIKSGRLSKELDLVSHHVRTK-----LDELKRQEV 111
LK++ ET++ H R I EI++ L + +L H+ K +DEL+R
Sbjct: 1205 LKELQKSFETERDHLR-----GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
Query: 112 GRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNH---LNPDKFESTD-------LDMLIKA 161
+ +I QD+ H L ++ L+ L P+ E ++ L++L +
Sbjct: 1260 EKTAQIINT-----QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQ 1314
Query: 162 ATS-DLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKV 220
+T+ D + E + E K E +E +K+L +E+ + K E ++ KH
Sbjct: 1315 STTKDSTTLARIEMERLRLNE--KFQESQEEIKSLTKERDNLKTIK-EALEVKH------ 1365
Query: 221 NHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNS--DGFLDEQELEALFTKELEKVY 278
DQLKE ET K+ + S + L+ +E + TK + ++
Sbjct: 1366 ------DQLKEHIRET------------LAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407
Query: 279 DPKNEEDDMVEMEEERLRMREHV------MNEVDTNKDRLVTLEEFLKATEKKEFLEPDS 332
K ++ ++ +E E L + + + M V KD L L+E L++ E + E +
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS-ESDQLKE--N 1464
Query: 333 WETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQV 392
+ + + TEEELK + QE + + L +++ E+ QLEA +
Sbjct: 1465 IKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNK 1524
Query: 393 IQQMEQKKLQQGI 405
IQ++ +K+ Q I
Sbjct: 1525 IQEIYEKEEQFNI 1537
Score = 46.6 bits (109), Expect = 4e-05
Identities = 82/411 (19%), Positives = 173/411 (42%), Gaps = 50/411 (12%)
Query: 22 LEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFRE-KLQKADI 80
L + + DK + +H + + G D+ + TD+ F+ K D
Sbjct: 770 LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF 829
Query: 81 EEIKSGRLSKELDLVSHHVRTKLDELKR--QEVGRLRMLIKAKLDSLQDIGMDHQALLKQ 138
E+ K + +E + ++ + E ++ +G L+ + K LQ+ + Q L +
Sbjct: 830 EQ-KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNE 888
Query: 139 FDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEE 198
+ L ++ E+ D +T +KT E K + E +KTL +E
Sbjct: 889 MEQLK----EQLENRD-------STLQTVEREKTLITE-------KLQQTLEEVKTLTQE 930
Query: 199 K----RKEEESKFEEMKKKHENHPKVN-HPGSKDQLKEVWE------ETDGLDPNDFDPK 247
K + +E + E + K + H VN + +++QL+ E ET + +
Sbjct: 931 KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEE 990
Query: 248 TFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDT 307
LH + G ++ + + + ++ + KN + ++++ + ++ + +
Sbjct: 991 VSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ 1050
Query: 308 NKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEE------ELKEYENIIALQEN-- 359
K+ L + E + A +KE L+ D E ++ EE ELK+ + I+A ++N
Sbjct: 1051 EKNELQQMLESVIA--EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
Query: 360 -----ELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQME--QKKLQQ 403
EL + D L + +E+L+ + QL+ ++ + V ++M QKK+ +
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
Score = 45.8 bits (107), Expect = 7e-05
Identities = 83/409 (20%), Positives = 174/409 (42%), Gaps = 56/409 (13%)
Query: 23 EAVPIDIDKT---KVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKAD 79
E + D++K K+ ++H E + G+ E ++ ++ + +H + L+ D
Sbjct: 1711 ETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV-SEKTNEISNMQKDLEHSNDALKAQD 1769
Query: 80 IEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQF 139
+ ++ +EL + H++ + ++ + +LR ++ K D L + + K
Sbjct: 1770 L------KIQEELRIAHMHLKEQ-----QETIDKLRGIVSEKTDKLSN-------MQKDL 1811
Query: 140 DHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEK 199
++ N +K + +KA L K +E KK M++ +++ ++L K
Sbjct: 1812 ENSNAKLQEKIQE------LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK 1865
Query: 200 RKEEE--------SKFEEMK---KKHENHPKVNHPGS--KDQLKEVWEETDGLDPN-DFD 245
+ E EEMK K+ +N +V +DQLKE +ET D +
Sbjct: 1866 LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE 1925
Query: 246 PKT---FFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEE--DDMVEMEEERLRMREH 300
KT K H D ++ + + +++K D +E + E++++ L++
Sbjct: 1926 LKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLR- 1984
Query: 301 VMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE 360
V +V+ + ++ +E+ K E + S +++ F ++L E I +
Sbjct: 1985 VKEDVNMSHKKINEMEQLKKQFEAQNL----SMQSVRMDNFQLTKKLHESLEEIRI---- 2036
Query: 361 LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSG 409
+ K+ DEL++ KE L+ + DQ A E +Q Q K ++ + G
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085
Score = 45.4 bits (106), Expect = 9e-05
Identities = 81/362 (22%), Positives = 165/362 (45%), Gaps = 48/362 (13%)
Query: 58 LKQVIDVL--ETDKHFREKLQKADIEEIKSGRL--SKELDLVSHHVRTKLDELKRQEVGR 113
+K+ ++V + +H RE L K + K + KE D + + +++++ K ++
Sbjct: 1357 IKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSAL 1416
Query: 114 LRMLIK--AKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDK 171
LR+ I+ LQ+ + +++ K+ D L L + ++ D L + + + +
Sbjct: 1417 LRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ--EVLQSESDQLKENIKEIVAKHLE 1474
Query: 172 TRHEEFKKYEMMKEHER--REYLKTLNEEK------RKEEESKFEEMKKKHENHPKVNHP 223
T E + +KE E E L+E++ +K+ E+ ++++ K + +
Sbjct: 1475 TEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQ 1534
Query: 224 GSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNE 283
+ Q+ EV E+ + L FK H D L Q +E+ + ++ + + E
Sbjct: 1535 FNIKQISEVQEKVNELKQ--------FKEHRKAKDSAL--QSIESKMLELTNRLQESQEE 1584
Query: 284 EDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKE--FLEPDSW-ETLD--- 337
M++ +EE R++E + E D K+ + +K +++KE FL+ + ET +
Sbjct: 1585 IQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMC 1644
Query: 338 -----QQQFFTEE---ELKEYENI---IALQEN-----ELKKKADELQKQKEELQRQHDQ 381
++QF T++ E E ENI L EN + K+ D+L+ +E L+ + DQ
Sbjct: 1645 EIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQ 1704
Query: 382 LE 383
L+
Sbjct: 1705 LK 1706
Score = 44.7 bits (104), Expect = 2e-04
Identities = 75/365 (20%), Positives = 152/365 (41%), Gaps = 67/365 (18%)
Query: 82 EIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDS--LQDIGMDHQALLKQF 139
E+ + L EL +R K D++K+ ++ +DS L++I MD L+
Sbjct: 567 EVYNQDLENELSSKVELLREKEDQIKK---------LQEYIDSQKLENIKMDLSYSLESI 617
Query: 140 DHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEK 199
+ +P + + T L A T L D R F + E ++ E+ + L T ++
Sbjct: 618 E-----DPKQMKQT----LFDAETVAL---DAKRESAFLRSENLELKEKMKELATTYKQM 665
Query: 200 RKEEE--SKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDF--DPKTFFKLHDV 255
+ + E KKK + + + +++ ++ DG P D + + K+ D+
Sbjct: 666 ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 725
Query: 256 NSDGFLDEQELEALF---------------TKELEKVYDPKNEEDDMVEMEEERLRMR-- 298
+ + +E EAL + L K K+EE ++ E+++L
Sbjct: 726 QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 785
Query: 299 ------EHVMNEVDTNKDRLVTLEEFLKAT--------------EKKEFLEPDSWETLDQ 338
+ ++ E+ KD L T + K+T E+K + + E ++Q
Sbjct: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 339 QQFFTEEELKEYENIIALQENELKKKADELQKQKEELQ---RQHDQLEAQKLEYHQVIQQ 395
+ +E +++++ + + EL K ELQ++ E+Q + +QL+ Q +Q
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
Query: 396 MEQKK 400
+E++K
Sbjct: 906 VEREK 910
Score = 41.2 bits (95), Expect = 0.002
Identities = 77/338 (22%), Positives = 158/338 (46%), Gaps = 62/338 (18%)
Query: 89 SKELDLVSHHVRTKLDELKR------------QEVGRLRMLIKAKLD-SLQDIGMDHQAL 135
++EL + V+ +L+E+++ Q V R + LI KL +L+++ + L
Sbjct: 872 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV----KTL 927
Query: 136 LKQFDHLNHLNPDKFESTDLDM-LIKAATSDLEHYDKTRHEEFKK-YEMMKEHERREYLK 193
++ D L L ES ++ +K+ D + + E+ + E +K+H+ +
Sbjct: 928 TQEKDDLKQLQ----ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQ-----E 978
Query: 194 TLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPN-DFDPKTFFKL 252
T+N K K E + H + N +KD+ ++ + G+D D + K L
Sbjct: 979 TINTLKSKISEEVSRNL------HMEENTGETKDEFQQ---KMVGIDKKQDLEAKNTQTL 1029
Query: 253 H-DVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEM---EEERLR--MREHVMNEVD 306
DV + +++Q +++ + KNE M+E E+E+L+ ++E++ ++
Sbjct: 1030 TADVKDNEIIEQQ-------RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE 1082
Query: 307 TNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKAD 366
N++ L L + LK +++E + + + + E EL + +A E +LK+K+
Sbjct: 1083 -NQEELRLLGDELK--KQQEIVAQEKNHAIKK-----EGELSRTCDRLAEVEEKLKEKSQ 1134
Query: 367 ELQ-KQKEELQRQHDQLEAQKL--EYHQVIQQMEQKKL 401
+LQ KQ++ L Q + E QK E + +++ K+L
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKEL 1172
Score = 37.4 bits (85), Expect = 0.026
Identities = 61/288 (21%), Positives = 113/288 (39%), Gaps = 44/288 (15%)
Query: 64 VLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLD 123
+ E + E + A +E K ++ KEL+ V++ + KL + K E + K +
Sbjct: 2383 IRELENSLHEAKESAMHKESKIIKMQKELE-VTNDIIAKL-QAKVHESNKCLEKTKETIQ 2440
Query: 124 SLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRH--EEFKKYE 181
LQD AL P K E DL M K DLE + +E +
Sbjct: 2441 VLQD----KVAL--------GAKPYKEEIEDLKM--KLVKIDLEKMKNAKEFEKEISATK 2486
Query: 182 MMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDP 241
E+++ E ++ L E R+ ++++ + +H + N P + + + T L
Sbjct: 2487 ATVEYQK-EVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKAL-- 2543
Query: 242 NDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHV 301
L + + KE+ K+ K + + +++ + E L +H+
Sbjct: 2544 ------------------ILKSEHIR--LEKEISKL---KQQNEQLIKQKNELLSNNQHL 2580
Query: 302 MNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKE 349
NEV T K+R + E + T + P T +++ T + KE
Sbjct: 2581 SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKE 2628
Score = 33.5 bits (75), Expect = 0.37
Identities = 22/75 (29%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 334 ETLDQQQFFTEEELKE---YENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYH 390
ETL QF + + + Y N ++ E LK+ E+ K++L+ + AQ +E
Sbjct: 315 ETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKD 374
Query: 391 QVIQQMEQKKLQQGI 405
Q+ Q +E+K L Q +
Sbjct: 375 QLAQLLEEKDLLQKV 389
Score = 29.6 bits (65), Expect = 5.4
Identities = 66/348 (18%), Positives = 132/348 (37%), Gaps = 51/348 (14%)
Query: 87 RLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLN 146
R+ K+L V +V TK+ E + + + + M D + ++ + L+K + HL
Sbjct: 2168 RIMKKLKYVLSYV-TKIKEEQHESINKFEM------DFIDEVEKQKELLIK----IQHLQ 2216
Query: 147 PDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNE-----EKRK 201
D + +L ++ + E++K+ E+ E RK
Sbjct: 2217 QD----------CDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRK 2266
Query: 202 EEESKFEEMKKKHENHPKVNHPGSK--DQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDG 259
E EE + K+ + K D++ +V N+F + + +++
Sbjct: 2267 EMTQFLEEWLNTRFDIEKLKNGIQKENDRICQV---------NNFFNNRIIAIMNESTEF 2317
Query: 260 FLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMR----EHVMNEVDTNKDRLVTL 315
+E A +KE E+ E+++ + + L+ V NK+ VT
Sbjct: 2318 ----EERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTS 2373
Query: 316 EEFLKATEKKEFLEPDSWETLDQQQ------FFTEEELKEYENIIALQENELKKKADELQ 369
TEK LE E + ++EL+ +IIA + ++ + L+
Sbjct: 2374 RATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLE 2433
Query: 370 KQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFE 417
K KE +Q D++ Y + I+ ++ K ++ + A E + E
Sbjct: 2434 KTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKE 2481
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 57.4 bits (137), Expect = 2e-08
Identities = 91/390 (23%), Positives = 173/390 (44%), Gaps = 63/390 (16%)
Query: 63 DVLETDKH-FREKLQKADIEEIKSGRLS---------KELDLVSH---HVRTKLDELKRQ 109
D L+++ H R L AD +E+ S +L KE + +S HV+ +LD L+ +
Sbjct: 794 DFLKSEVHDLRVVLHSAD-KELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLE 852
Query: 110 EVGRLRMLIKAKLDSLQDIGMDHQALLK-QFDHL-----NHLNPDKFESTDLDMLIKAAT 163
L+++K LQD + Q ++K + D L N ++ +DL+ L++
Sbjct: 853 N----EKLLESKA-CLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLE 907
Query: 164 SDLEHYDKTRHEEFKKYEMMKEHERREYLKTLN---EEKRKEEESKFEEMKKKHENHPKV 220
++ E +K + +E KE+ +E LK L +EK+KE ++M K +
Sbjct: 908 AEKERNNKLSLQ----FEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQK----- 958
Query: 221 NHPGSKDQLKEVWEETDGLDPN-DFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYD 279
++ L + L+ + D D K V +D QEL ++ E +
Sbjct: 959 ----LEESLLATEKVISSLEKSRDSDKK-------VVADLMNQIQELRTSVCEKTETIDT 1007
Query: 280 PKNEEDD--------MVEMEEERLRMREHVMNEVDTNKD-RLVTLEEFLKATEKKEFLEP 330
K E D +V+ EE R+ +++ ++ +D + RL L E ++ ++ L
Sbjct: 1008 LKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIE----RDMLCE 1063
Query: 331 DSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYH 390
D +Q TE K++ ++ + EL KK +Q+ + +L ++ +++E +K EY+
Sbjct: 1064 DLAHATEQLNMLTEAS-KKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYN 1122
Query: 391 QVIQQMEQKKLQQGIPPSGPAGELKFEPHI 420
++Q+E P P F+ H+
Sbjct: 1123 FKMRQLEHVMDSAAEDPQSPKTPPHFQTHL 1152
Score = 35.0 bits (79), Expect = 0.13
Identities = 83/385 (21%), Positives = 151/385 (39%), Gaps = 72/385 (18%)
Query: 73 EKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDH 132
EKL K E + G L +E D + +R ++ L+ Q R+ A M++
Sbjct: 471 EKLHK----ESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYA---------MEN 517
Query: 133 QALLKQFDHLNHLNPDK----FESTDLDMLIKAAT--SDLEHYDKTRH------------ 174
+L ++ L L P K ++ + L KA + S +E DK +
Sbjct: 518 HSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCL 577
Query: 175 ----EEFK------KYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHEN------HP 218
E+ K + E+ + E K L +++ E ES+ + ++K + N
Sbjct: 578 FANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEAT 637
Query: 219 KVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLH---------DVNSDGFLDEQELEAL 269
K QL ++ ET + P ++LH ++ S G L Q L
Sbjct: 638 KACKRQEVSQLNKIHAETLKIITT---PTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSIL 694
Query: 270 FTKELEKVYDPKNEEDDMVEMEEERLRMREHV---MNEVDTNKDRLVTLEEFLKATE--K 324
L + P+ E + EE ++E + ++D + + + L++ + E
Sbjct: 695 DNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHS 754
Query: 325 KEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQ----RQHD 380
+ E S E +D + +EEL N++ Q E + K D L+ + +L+
Sbjct: 755 TQMQELFSSERIDWTK--QQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADK 812
Query: 381 QLEAQKLEY--HQVIQQMEQKKLQQ 403
+L + KLEY + Q+ E KL +
Sbjct: 813 ELSSVKLEYSSFKTNQEKEFNKLSE 837
Score = 34.7 bits (78), Expect = 0.17
Identities = 77/369 (20%), Positives = 146/369 (39%), Gaps = 70/369 (18%)
Query: 59 KQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLI 118
KQ +D+L+ + R ++ DIE L ++L + + L E ++ G L+
Sbjct: 1035 KQEVDILDLKETLRLRILSEDIER---DMLCEDLAHATEQLNM-LTEASKKHSGLLQ--- 1087
Query: 119 KAKLDSLQDIGMDHQALLKQFDH-LNHL--------NPDKFESTDLDMLIKAATSDLEHY 169
S Q+ +AL+++ H LN N F+ L+ ++ +A D +
Sbjct: 1088 -----SAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSP 1142
Query: 170 DKTRHEEFKKYEMMKEHERR-----------EYLKTLNEEKRKEEESKFEEMKKKHENHP 218
H + ++++ E+ E+L T E R+ + ++ MK++
Sbjct: 1143 KTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREME 1202
Query: 219 KVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSD-GFLDEQELEALFTKELEKV 277
+ S+ +++ W LD K NSD D Q+L
Sbjct: 1203 NLRLE-SQQLIEKNWLLQGQLDD--------IKRQKENSDQNHPDNQQL----------- 1242
Query: 278 YDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFL------EPD 331
KNE+++ ++ ERL + V + D LEE A KE E +
Sbjct: 1243 ---KNEQEESIK---ERLAKSKIVEEMLKMKAD----LEEVQSALYNKEMECLRMTDEVE 1292
Query: 332 SWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQ 391
+TL+ + F +E+L+ + + ++ + L+KQ E L ++ +L + HQ
Sbjct: 1293 RTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQ-NLHQ 1351
Query: 392 VIQQMEQKK 400
IQ + + K
Sbjct: 1352 KIQYVVRLK 1360
Score = 32.3 bits (72), Expect = 0.83
Identities = 34/178 (19%), Positives = 72/178 (40%), Gaps = 25/178 (14%)
Query: 171 KTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKV-NHPGSKDQL 229
K R ++ + E + + R +L + E ++ + ++++ E+HP+V + L
Sbjct: 461 KFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSL 520
Query: 230 KEVWEETDGLDP----NDFDPKTFFKLH------------DVNSDGFLDEQELEALFTKE 273
+E L+P + D +T KL D N GF + + E
Sbjct: 521 REENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFAN 580
Query: 274 LEKV--------YDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATE 323
EK+ + N + + E +E + + + +E+ + + + LE L+AT+
Sbjct: 581 TEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATK 638
Score = 30.8 bits (68), Expect = 2.4
Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 5/111 (4%)
Query: 41 ESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQ-KADIEEIKSGRLSKELD---LVS 96
E++ PD +E + + + L K E L+ KAD+EE++S +KE++ +
Sbjct: 1230 ENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTD 1289
Query: 97 HHVRTKLDELKR-QEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLN 146
RT+ E K QE +LR ++ + + + + L KQ + L N
Sbjct: 1290 EVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEEN 1340
>gi|239752551 PREDICTED: hypothetical protein [Homo sapiens]
Length = 238
Score = 56.2 bits (134), Expect = 5e-08
Identities = 54/233 (23%), Positives = 119/233 (51%), Gaps = 47/233 (20%)
Query: 183 MKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPN 242
M+E ER ++ ++ R+EEE E+ +K E K+ ++Q +++WE+ + +
Sbjct: 1 MREEER---MREREKKMREEEEMMREQEEKMQEQEEKM-----REQEEKMWEQEEKMQEQ 52
Query: 243 DFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKN--EEDDMVEMEEERLRMREH 300
+ + EQE E ++ +E EK+++ + E+ + + ++ERLR +E
Sbjct: 53 EEK---------------MWEQE-EKMWEQE-EKMWEQQRLPEQKEKMWEQDERLREKEE 95
Query: 301 VMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE 360
M E ++ K EKK+ E E + +Q EE+++E E ++ QE +
Sbjct: 96 RMREQKM-------WQQVEKMREKKKTQE----EKMQEQ----EEKMQEQEEMMWEQEEK 140
Query: 361 LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGE 413
++++ +++ +Q+E+++ Q +++ Q+ + Q +++K++ P G AGE
Sbjct: 141 MQEQEEKMWEQEEKMREQEEKMREQEEK-----MQGQEEKMRDVEPAGGEAGE 188
Score = 54.3 bits (129), Expect = 2e-07
Identities = 44/209 (21%), Positives = 103/209 (49%), Gaps = 36/209 (17%)
Query: 175 EEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKK-HENHPKVNHPGSKDQLKEVW 233
EE + E K+ E + EEK +E+E K E ++K E K+ ++Q +++W
Sbjct: 3 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKM-----QEQEEKMW 57
Query: 234 EETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEE 293
E+ + + EQE + + L + + E+D+ + +EE
Sbjct: 58 EQEEK----------------------MWEQEEKMWEQQRLPEQKEKMWEQDERLREKEE 95
Query: 294 RLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENI 353
R+R + + +V+ +++ T EE ++ E+K + ++ + EE+++E E
Sbjct: 96 RMR-EQKMWQQVEKMREKKKTQEEKMQEQEEK-------MQEQEEMMWEQEEKMQEQEEK 147
Query: 354 IALQENELKKKADELQKQKEELQRQHDQL 382
+ QE +++++ +++++Q+E++Q Q +++
Sbjct: 148 MWEQEEKMREQEEKMREQEEKMQGQEEKM 176
Score = 33.1 bits (74), Expect = 0.48
Identities = 27/130 (20%), Positives = 58/130 (44%), Gaps = 29/130 (22%)
Query: 178 KKYEMMKEHER-REYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEET 236
+K +M ++ ER RE + + E+K ++ K E KK E + ++Q + +WE+
Sbjct: 79 QKEKMWEQDERLREKEERMREQKMWQQVEKMREKKKTQEEKMQEQEEKMQEQEEMMWEQE 138
Query: 237 DGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLR 296
+ + QE E ++ EK+ E+++ + +EE+++
Sbjct: 139 EKM------------------------QEQEEKMWEQEEKM----REQEEKMREQEEKMQ 170
Query: 297 MREHVMNEVD 306
+E M +V+
Sbjct: 171 GQEEKMRDVE 180
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 55.8 bits (133), Expect = 7e-08
Identities = 94/373 (25%), Positives = 154/373 (41%), Gaps = 58/373 (15%)
Query: 63 DVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKL 122
+ + + +E + K +E + LS +L+ + ++ ++ R++ R LIKAK
Sbjct: 820 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL-ADMEAKFREKDEREEQLIKAKE 878
Query: 123 DSLQDI-------GMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHE 175
DI G + L K D L D E L + + A + K+ +
Sbjct: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE---LQLKLTKANENASFLQKSIED 935
Query: 176 EFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHP------KVNHPGSKDQL 229
K E ++ +++ EE++KE E K +++KK E K + + +
Sbjct: 936 MTVKAEQSQQEAAKKH-----EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSET 990
Query: 230 KEVWEET-DGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMV 288
K EE L D + K + G L QELE L K+ +K + ED M
Sbjct: 991 KTKHEEILQNLQKTLLDTEDKLKGAREENSGLL--QELEEL-RKQADKAKAAQTAEDAMQ 1047
Query: 289 EME-------------EERLRMREHVMNEVDTNKD-RLVTLEEFLKATEKKEFLEPDSWE 334
ME E+ + + NE+DT K+ L +EE K+ KE L
Sbjct: 1048 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS---KELL------ 1098
Query: 335 TLDQQQFFTEEELKEYENI---IALQENELKKKADELQKQKEELQRQHDQLEA-QKLEYH 390
T++ Q+ EE KE E + A + +L +E K EEL R D++ + QKLE
Sbjct: 1099 TVENQKM--EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEE 1156
Query: 391 QVI---QQMEQKK 400
+ + Q +E KK
Sbjct: 1157 RSVLNNQLLEMKK 1169
Score = 51.2 bits (121), Expect = 2e-06
Identities = 70/391 (17%), Positives = 161/391 (41%), Gaps = 39/391 (9%)
Query: 19 LTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKA 78
+ AL A + + K K ++ + S K++ + D++L ++ D L + K+++
Sbjct: 646 MEALRAKLMKVIKEKENSLEAIRS-KLDKAE-----DQHLVEMEDTLNKLQEAEIKVKEL 699
Query: 79 DIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQ 138
++ + K +K +D + + K E K ++ LR ++ + +A KQ
Sbjct: 700 EVLQAKCNEQTKVIDNFTSQL--KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 757
Query: 139 FDHLN-HLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNE 197
HL N + +++ + ++ L + E + +KE +E L+ L E
Sbjct: 758 IKHLEIEKNAESSKASSITRELQGRELKLTNLQ----ENLSEVSQVKETLEKE-LQILKE 812
Query: 198 EKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNS 257
+ + E + E K++ ++Q + + + L N D + F+ D
Sbjct: 813 KFAEASEEAVSVQRSMQETVNKLHQ--KEEQFNMLSSDLEKLRENLADMEAKFREKDERE 870
Query: 258 DGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEE 317
+ + +E ++ ++ + + + LR++E + E+ +
Sbjct: 871 EQLIKAKEK---LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL---------K 918
Query: 318 FLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKE---- 373
KA E FL+ + + + +E K++E ++ EL++K +L+K+ E
Sbjct: 919 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE----EKKELERKLSDLEKKMETSHN 974
Query: 374 ---ELQRQHDQLEAQKLEYHQVIQQMEQKKL 401
EL+ ++++ ++ H+ I Q QK L
Sbjct: 975 QCQELKARYERATSETKTKHEEILQNLQKTL 1005
Score = 30.0 bits (66), Expect = 4.1
Identities = 70/365 (19%), Positives = 144/365 (39%), Gaps = 59/365 (16%)
Query: 66 ETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSL 125
E +H + L + D+E + + + + + + L R + + ++AK+D L
Sbjct: 359 EKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA-----LARDGHDQHVLELEAKMDQL 413
Query: 126 QDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAAT---SDLEHY---DKTRHEEFKK 179
+ M A ++ + LN L +K + DL ++ + DLE +K+R E +K
Sbjct: 414 RT--MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEK 471
Query: 180 YEMMKEHERREYLKTLNEEKR-----------KEEESKFEEMKKKHENHPKV-----NHP 223
++ E E + L K +E S E+++ +H + H
Sbjct: 472 DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF 531
Query: 224 GSKDQ-----LKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVY 278
G++++ +K ++ T+ L + K+ KL N + ++ AL+ +LE
Sbjct: 532 GAREETHQKEIKALYTATEKLSKENESLKS--KLEHANKEN----SDVIALWKSKLETAI 585
Query: 279 DPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQ 338
+ MEE ++ + + E EF + + E + D ++
Sbjct: 586 ASHQQA-----MEELKVSFSKGLGTET----------AEFAELKTQIEKMRLDYQHEIEN 630
Query: 339 QQFFTEEE----LKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQ 394
Q + E KE E + A +K+K + L+ + +L + DQ + + +Q
Sbjct: 631 LQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ 690
Query: 395 QMEQK 399
+ E K
Sbjct: 691 EAEIK 695
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 55.8 bits (133), Expect = 7e-08
Identities = 94/373 (25%), Positives = 154/373 (41%), Gaps = 58/373 (15%)
Query: 63 DVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKL 122
+ + + +E + K +E + LS +L+ + ++ ++ R++ R LIKAK
Sbjct: 855 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL-ADMEAKFREKDEREEQLIKAKE 913
Query: 123 DSLQDI-------GMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHE 175
DI G + L K D L D E L + + A + K+ +
Sbjct: 914 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE---LQLKLTKANENASFLQKSIED 970
Query: 176 EFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHP------KVNHPGSKDQL 229
K E ++ +++ EE++KE E K +++KK E K + + +
Sbjct: 971 MTVKAEQSQQEAAKKH-----EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSET 1025
Query: 230 KEVWEET-DGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMV 288
K EE L D + K + G L QELE L K+ +K + ED M
Sbjct: 1026 KTKHEEILQNLQKTLLDTEDKLKGAREENSGLL--QELEEL-RKQADKAKAAQTAEDAMQ 1082
Query: 289 EME-------------EERLRMREHVMNEVDTNKD-RLVTLEEFLKATEKKEFLEPDSWE 334
ME E+ + + NE+DT K+ L +EE K+ KE L
Sbjct: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS---KELL------ 1133
Query: 335 TLDQQQFFTEEELKEYENI---IALQENELKKKADELQKQKEELQRQHDQLEA-QKLEYH 390
T++ Q+ EE KE E + A + +L +E K EEL R D++ + QKLE
Sbjct: 1134 TVENQKM--EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEE 1191
Query: 391 QVI---QQMEQKK 400
+ + Q +E KK
Sbjct: 1192 RSVLNNQLLEMKK 1204
Score = 51.2 bits (121), Expect = 2e-06
Identities = 70/391 (17%), Positives = 161/391 (41%), Gaps = 39/391 (9%)
Query: 19 LTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKA 78
+ AL A + + K K ++ + S K++ + D++L ++ D L + K+++
Sbjct: 681 MEALRAKLMKVIKEKENSLEAIRS-KLDKAE-----DQHLVEMEDTLNKLQEAEIKVKEL 734
Query: 79 DIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQ 138
++ + K +K +D + + K E K ++ LR ++ + +A KQ
Sbjct: 735 EVLQAKCNEQTKVIDNFTSQL--KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 792
Query: 139 FDHLN-HLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNE 197
HL N + +++ + ++ L + E + +KE +E L+ L E
Sbjct: 793 IKHLEIEKNAESSKASSITRELQGRELKLTNLQ----ENLSEVSQVKETLEKE-LQILKE 847
Query: 198 EKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNS 257
+ + E + E K++ ++Q + + + L N D + F+ D
Sbjct: 848 KFAEASEEAVSVQRSMQETVNKLHQ--KEEQFNMLSSDLEKLRENLADMEAKFREKDERE 905
Query: 258 DGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEE 317
+ + +E ++ ++ + + + LR++E + E+ +
Sbjct: 906 EQLIKAKEK---LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL---------K 953
Query: 318 FLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKE---- 373
KA E FL+ + + + +E K++E ++ EL++K +L+K+ E
Sbjct: 954 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE----EKKELERKLSDLEKKMETSHN 1009
Query: 374 ---ELQRQHDQLEAQKLEYHQVIQQMEQKKL 401
EL+ ++++ ++ H+ I Q QK L
Sbjct: 1010 QCQELKARYERATSETKTKHEEILQNLQKTL 1040
Score = 38.5 bits (88), Expect = 0.012
Identities = 77/380 (20%), Positives = 153/380 (40%), Gaps = 54/380 (14%)
Query: 66 ETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSL 125
E +H + L + D+E + + + + + + L R + + ++AK+D L
Sbjct: 359 EKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA-----LARDGHDQHVLELEAKMDQL 413
Query: 126 QDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAAT---SDLEHYDKTRHEEFKKYE- 181
+ M A ++ + LN L +K + DL ++ + DLE K H K+ E
Sbjct: 414 RT--MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQ 471
Query: 182 -MMKEHERREYLKTLNEEKRK---EEESKFEEMKKK---------------HENHPKVNH 222
++ E + + L+ E+ R E+S+ E++K N P +
Sbjct: 472 SLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV 531
Query: 223 PGSKDQLKEVWEETDGLDPNDFDPK---TFFKLHDVNSDGFLDEQELEALFT------KE 273
S L+E+ + L+ D + T K H + ++E++AL+T KE
Sbjct: 532 DMSLSLLQEISSLQEKLEVTRTDHQREITSLKEH-FGAREETHQKEIKALYTATEKLSKE 590
Query: 274 LE----KVYDPKNEEDDMVEMEEERLRM----REHVMNEVDTNKDRLVTLE--EFLKATE 323
E K+ E D++ + + +L + M E+ + + + E EF +
Sbjct: 591 NESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKT 650
Query: 324 KKEFLEPDSWETLDQQQFFTEEE----LKEYENIIALQENELKKKADELQKQKEELQRQH 379
+ E + D ++ Q + E KE E + A +K+K + L+ + +L +
Sbjct: 651 QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE 710
Query: 380 DQLEAQKLEYHQVIQQMEQK 399
DQ + + +Q+ E K
Sbjct: 711 DQHLVEMEDTLNKLQEAEIK 730
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 55.5 bits (132), Expect = 9e-08
Identities = 77/366 (21%), Positives = 155/366 (42%), Gaps = 40/366 (10%)
Query: 46 EPPDTGLYYDEYLKQVIDVLETDKHFR-EKLQ----KADIEEIKSGRLSKELDLVSHHVR 100
EPP + Y KQ + L+ ++H E+LQ K + ++ + L H V+
Sbjct: 442 EPPQSARRKRSY-KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQ 500
Query: 101 TKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIK 160
+++ R ++K+ + + MD + + + N + E + +
Sbjct: 501 R--NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAE-----Q 553
Query: 161 AATSDLEHYDKTRHEEFK---KYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENH 217
+E + R EE K + + K + RE ++ + EEK+K+ E KF ++ +K E
Sbjct: 554 LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA 613
Query: 218 PKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKV 277
+ K + K ++ + ++ + +L +L ++E E + L+K
Sbjct: 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR------WLQQEEEERRHQELLQK- 666
Query: 278 YDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLD 337
K EE + + E R+ E E E+ + E++E +
Sbjct: 667 --KKEEEQERLRKAAEAKRLAEQREQE---------RREQERREQERREQERREQERREQ 715
Query: 338 QQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQL----EAQKLEYHQVI 393
++Q +E +E E + A E EL+++ L+ QKE+LQR+ ++ E Q+L Q+
Sbjct: 716 ERQLAEQERRREQERLQA--ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 773
Query: 394 QQMEQK 399
++ E+K
Sbjct: 774 EEQEKK 779
Score = 43.9 bits (102), Expect = 3e-04
Identities = 42/164 (25%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 262 DEQELEALFTKE-LEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLK 320
+ Q LE L KE E++ K EED +EE +L+ RE + +V ++R+ ++E K
Sbjct: 538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK-REERLRKVLQARERVEQMKEEKK 596
Query: 321 ATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADE------------- 367
+++F + D +++ EE+ K+ ++E E ++K +E
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
Query: 368 -------LQKQKEE-LQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
LQK+KEE +R EA++L + ++ EQ++ +Q
Sbjct: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 700
Score = 35.8 bits (81), Expect = 0.075
Identities = 44/233 (18%), Positives = 100/233 (42%), Gaps = 45/233 (19%)
Query: 178 KKYEMMKEHERREYLKTLNEEKRKEEESK-FEEMK-KKHENHPKVNHPGSK-DQLKEVWE 234
K+ + ++ R+E + L +K +E++ + EE+K K+ E KV + +Q+KE +
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 596
Query: 235 ETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDM-----VE 289
+ D KT + +E+ + K++E+V + +E++ ++
Sbjct: 597 KQIEQKFAQIDEKT----EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
Query: 290 MEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKE 349
EEE R +E + + + ++RL KA E K E
Sbjct: 653 QEEEERRHQELLQKKKEEEQERL------RKAAEAKRLAE-------------------- 686
Query: 350 YENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQ 402
Q + +++ + ++++ E +R+ + Q+ + + ++ EQ++LQ
Sbjct: 687 -------QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
Score = 32.0 bits (71), Expect = 1.1
Identities = 18/82 (21%), Positives = 48/82 (58%), Gaps = 3/82 (3%)
Query: 325 KEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE---LKKKADELQKQKEELQRQHDQ 381
K F++ ++ +D + F E+E + EN+ +E E +K ++ +++ EE++ + ++
Sbjct: 517 KSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE 576
Query: 382 LEAQKLEYHQVIQQMEQKKLQQ 403
+ L+ + ++QM+++K +Q
Sbjct: 577 RLRKVLQARERVEQMKEEKKKQ 598
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 55.1 bits (131), Expect = 1e-07
Identities = 55/243 (22%), Positives = 109/243 (44%), Gaps = 13/243 (5%)
Query: 62 IDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAK 121
+D+ E D F EK + +E K R ++L + K +++ +E R +
Sbjct: 2118 LDIKEWD--FSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVI 2175
Query: 122 LDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYE 181
LD ++ G++ + ++ L + E+ D + +S ++ + H +
Sbjct: 2176 LDDEEEGGIEEEEVIP---FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMES 2232
Query: 182 MMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDP 241
++ E E++E L + EE+R+EEE + EE ++ E K G + Q+++ EE
Sbjct: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK---- 2288
Query: 242 NDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHV 301
K K +V + E++ E + +E E + D + EE++ +EEE R +E +
Sbjct: 2289 ---KKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSD-EEEEEESCSLEEEVDREKEIL 2344
Query: 302 MNE 304
E
Sbjct: 2345 KKE 2347
Score = 51.6 bits (122), Expect = 1e-06
Identities = 72/321 (22%), Positives = 142/321 (44%), Gaps = 46/321 (14%)
Query: 107 KRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDL 166
KR+ + + + L +LQ + D + L ++ + + F + + I+ + D+
Sbjct: 2062 KRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVK-ERRLSIEQSKLDI 2120
Query: 167 EHYDKTRHEEFKKYEMMKEHER--REYLKTLNEEKR--KEEESKFEEMKKKHENHPKV-- 220
+ +D + K+ E+ K+ ++ R+ K N+ +R +EE EE K H +V
Sbjct: 2121 KEWDFSE----KRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVIL 2176
Query: 221 ---NHPGSKDQ-----LKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTK 272
G +++ LK W + D PK F +DE E E F++
Sbjct: 2177 DDEEEGGIEEEEVIPFLKRRWRKRKEAKRGD-KPKEKFSSQ-------VDEVESEEHFSE 2228
Query: 273 ELEKVYDPKNEEDDMV-EMEEER----------LRMREHVMNEVDTNKDRLVTLEEFLKA 321
E+E + D +++ + E EEER +R E E + +++ V EE K
Sbjct: 2229 EMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK 2288
Query: 322 TEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQ 381
+KKE + + E ++ F +EE+ E +L + E ++++ L+ EE+ R+ +
Sbjct: 2289 KKKKEKKKEEVQE--KEEVFEEKEEIMSEEETESLSDEEEEEESCSLE---EEVDREKEI 2343
Query: 382 LEAQKLEYHQVIQQMEQKKLQ 402
L+ +K +Q+ +K L+
Sbjct: 2344 LKKEK---QFKLQEQRRKSLR 2361
Score = 50.1 bits (118), Expect = 4e-06
Identities = 70/357 (19%), Positives = 148/357 (41%), Gaps = 42/357 (11%)
Query: 59 KQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLI 118
K+ + ET + R++ +E+ +LS E ++ H R E G+L
Sbjct: 1981 KETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTR 2040
Query: 119 KAKL--DSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEE 176
++ + + + L+K+ + L+ E L+ ++KA K EE
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKRESLSK------EPAKLNKILKALQKLTRDERKLTQEE 2094
Query: 177 FKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEET 236
K +M + +E ++ + K +E F E K K ++ Q K +
Sbjct: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSE---KRSELTKDEKKLARKQRKLANKMR 2151
Query: 237 DGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLR 296
++ + + KL +S+ LD++E + EE++++ + R R
Sbjct: 2152 RMINKEEKMTEEESKLARKHSEVILDDEEEGGI-------------EEEEVIPFLKRRWR 2198
Query: 297 MREHV-------------MNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFT 343
R+ ++EV++ + +E L EK+E L + E ++++
Sbjct: 2199 KRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEERE 2258
Query: 344 EEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK 400
EEE++E E +E + +++ +E Q +KEE +++ + E +K E + + E+K+
Sbjct: 2259 EEEVREEE-----EERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKE 2310
Score = 37.0 bits (84), Expect = 0.034
Identities = 28/118 (23%), Positives = 59/118 (50%), Gaps = 12/118 (10%)
Query: 283 EEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFF 342
E++ E+EE M E E + N++ +EE K E++E L +W+
Sbjct: 1711 EKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEAL---AWQ-------- 1759
Query: 343 TEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKK 400
E+L E E +A +E L ++ ++L + KE++ + ++L ++ + + ++ QK+
Sbjct: 1760 -REKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKR 1816
Score = 36.2 bits (82), Expect = 0.057
Identities = 52/247 (21%), Positives = 104/247 (42%), Gaps = 26/247 (10%)
Query: 170 DKTRH--EEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKD 227
++ RH EE K + ++ R E + E K +EE K + +++ +
Sbjct: 1563 EEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEER-------- 1614
Query: 228 QLKEVWEET--DGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTK--ELEKVYDPKNE 283
+L + + + D + + K K + G QE E L K +L K ++
Sbjct: 1615 KLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAR 1674
Query: 284 EDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFT 343
E++ + + +L V N + + L E+ L EK+ E + E ++ +
Sbjct: 1675 EEEKLAKKGGKLA---EVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWK 1731
Query: 344 EEELKEYENIIALQENELKKKADELQKQKEELQRQHDQL---------EAQKLEYHQVIQ 394
EEEL + E + ++ +L ++ + L Q+E+L + +L E +KL H+
Sbjct: 1732 EEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKM 1791
Query: 395 QMEQKKL 401
E+++L
Sbjct: 1792 PEEEERL 1798
Score = 33.5 bits (75), Expect = 0.37
Identities = 73/338 (21%), Positives = 127/338 (37%), Gaps = 58/338 (17%)
Query: 69 KHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDI 128
K +K +K EE K + +L V + + K++EL ++E L K L+++
Sbjct: 1663 KKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQN-LDWQEKELAQELEEL 1721
Query: 129 GMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHER 188
D + L + + LN EE K E K+
Sbjct: 1722 EWDMEELSWKEEELNQ------------------------------EEGKLVEEKKKLAE 1751
Query: 189 REYLKTLNEEKRKEEESKF--EEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDP 246
E EK EEE+K EE E H K+++ E E +
Sbjct: 1752 EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQH---KEKMPEEEERLGRKREQLIEK 1808
Query: 247 KTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKN--EEDDMVEMEEERLRMRE----- 299
K KL +EL TK +Y KN +E + E+E+L R+
Sbjct: 1809 K--MKLAQKRERWINSMEEL----TKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLY 1862
Query: 300 ------HVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENI 353
H ++ K++L + L E+K E ++ ++ TE++L + E+
Sbjct: 1863 NKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDS 1922
Query: 354 IALQENELKKKADELQKQKEELQ---RQHDQLEAQKLE 388
+A ++ +L ++ +L +K +Q R +L+ K E
Sbjct: 1923 LAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEE 1960
Score = 32.7 bits (73), Expect = 0.63
Identities = 21/81 (25%), Positives = 42/81 (51%)
Query: 315 LEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEE 374
L+E K + E L P+ + ++ EE + +EN+++ + E + K +E +EE
Sbjct: 1490 LQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEE 1549
Query: 375 LQRQHDQLEAQKLEYHQVIQQ 395
+ R+ ++ E Q E + IQ+
Sbjct: 1550 VSREGEEKEQQVTEEQRHIQE 1570
Score = 31.6 bits (70), Expect = 1.4
Identities = 34/141 (24%), Positives = 65/141 (46%), Gaps = 4/141 (2%)
Query: 263 EQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKAT 322
++E E +E EK++ + EM +E +++ +V N + E+ K
Sbjct: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE 1541
Query: 323 EKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQL 382
E+ E S E +++Q TEE+ E + + + +A++ + Q+E Q ++
Sbjct: 1542 EEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEK 1601
Query: 383 EAQKLEYHQVIQQMEQKKLQQ 403
AQ E Q+ Q E++KL Q
Sbjct: 1602 LAQ--EERQLAQ--EERKLAQ 1618
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 55.1 bits (131), Expect = 1e-07
Identities = 79/345 (22%), Positives = 158/345 (45%), Gaps = 61/345 (17%)
Query: 69 KHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRM-LIKAKLDSLQD 127
K F LQ E L E + +L EL+ ++ +L M L K K +SL+D
Sbjct: 54 KQFLRLLQNEQFE------LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD 107
Query: 128 IGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYE------ 181
M Q + + E +L+ +KAA + E + ++ KYE
Sbjct: 108 EKMRQQ-----------VRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDA 156
Query: 182 -----MMKEHERREYLKTLNEEKRKEEESKFE-EMKKKHENHPKVNHPGSKDQLKE---- 231
MM+EH+R + E+KR + ++++ +++K+ E K + LKE
Sbjct: 157 EIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMI 216
Query: 232 ------VWEETDGLDPNDFDPKTFFKLHDVNS-DGFLDE-QELEALFTKELEKVYDPKNE 283
++EE D L+ KL +N+ +++E Q+ +AL+ K+ + + +N
Sbjct: 217 DEIVRKIYEE-DQLEKQQ-------KLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENR 268
Query: 284 EDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFT 343
+ ++E + + E M +V N+++ + L+ L ++ + + E + +Q+ +
Sbjct: 269 K--IIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQV-RQELYQ 325
Query: 344 EEELKEYENIIALQENELKKKAD-ELQKQKEELQRQHDQLEAQKL 387
EE+ + Y +++LK++A+ +L+KQKE Q +Q+ ++L
Sbjct: 326 EEQAEIY-------KSKLKEEAEKKLRKQKEMKQDFEEQMALKEL 363
Score = 38.1 bits (87), Expect = 0.015
Identities = 44/253 (17%), Positives = 111/253 (43%), Gaps = 44/253 (17%)
Query: 187 ERREYLKTLNEEK----------RKEEESKFEEMKKKHENH-----PKVNHPGSKDQLKE 231
+R+++L+ L E+ + EE + +E++ K E K+ H KD+
Sbjct: 52 QRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMR 111
Query: 232 VWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEME 291
+ ++ + + K K +N + E +A+ +++++ + E ME
Sbjct: 112 QQVRENSIELRELEKK--LKAAYMNKERAAQIAEKDAIKYEQMKR-----DAEIAKTMME 164
Query: 292 EERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYE 351
E + ++E E NK + + K E++E + +++E L +++ +E +++
Sbjct: 165 EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIY 224
Query: 352 NIIALQENELKKKADELQKQKEELQRQH--------DQLEAQK---LEYHQV-------- 392
L++ + +K + +++ EE Q++ +++E + +E+ +
Sbjct: 225 EEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDR 284
Query: 393 ---IQQMEQKKLQ 402
+Q+ E+K+LQ
Sbjct: 285 MAKVQENEEKRLQ 297
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 55.1 bits (131), Expect = 1e-07
Identities = 81/366 (22%), Positives = 157/366 (42%), Gaps = 44/366 (12%)
Query: 46 EPPDTGLYYDEYLKQVIDVLETDKHFR-EKLQ----KADIEEIKSGRLSKELDLVSHHVR 100
EPP + Y KQ + L+ ++H E+LQ K + ++ + L H V+
Sbjct: 442 EPPQSARRKRSY-KQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQ 500
Query: 101 TKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIK 160
+++ R ++K+ + + MD + K+ L +L K E+ L
Sbjct: 501 R--NQMLMTPTSAPRSVMKSFIKRNTPLRMDPKE--KERQRLENLRR-KEEAEQL----- 550
Query: 161 AATSDLEHYDKTRHEEFK---KYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENH 217
+E + R EE K + + K + RE ++ + EEK+K+ E KF ++ +K E
Sbjct: 551 -RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA 609
Query: 218 PKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKV 277
+ K + K ++ + ++ + +L +L ++E E + L+K
Sbjct: 610 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR------WLQQEEEERRHQELLQK- 662
Query: 278 YDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLD 337
K EE + + E R+ E E E+ + E++E +
Sbjct: 663 --KKEEEQERLRKAAEAKRLAEQREQE---------RREQERREQERREQERREQERREQ 711
Query: 338 QQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQL----EAQKLEYHQVI 393
++Q +E +E E + A E EL+++ L+ QKE+LQR+ ++ E Q+L Q+
Sbjct: 712 ERQLAEQERRREQERLQA--ERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ 769
Query: 394 QQMEQK 399
++ E+K
Sbjct: 770 EEQEKK 775
Score = 43.9 bits (102), Expect = 3e-04
Identities = 42/164 (25%), Positives = 79/164 (48%), Gaps = 23/164 (14%)
Query: 262 DEQELEALFTKE-LEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLK 320
+ Q LE L KE E++ K EED +EE +L+ RE + +V ++R+ ++E K
Sbjct: 534 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK-REERLRKVLQARERVEQMKEEKK 592
Query: 321 ATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADE------------- 367
+++F + D +++ EE+ K+ ++E E ++K +E
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
Query: 368 -------LQKQKEE-LQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
LQK+KEE +R EA++L + ++ EQ++ +Q
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 696
Score = 35.8 bits (81), Expect = 0.075
Identities = 44/233 (18%), Positives = 100/233 (42%), Gaps = 45/233 (19%)
Query: 178 KKYEMMKEHERREYLKTLNEEKRKEEESK-FEEMK-KKHENHPKVNHPGSK-DQLKEVWE 234
K+ + ++ R+E + L +K +E++ + EE+K K+ E KV + +Q+KE +
Sbjct: 533 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 592
Query: 235 ETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDM-----VE 289
+ D KT + +E+ + K++E+V + +E++ ++
Sbjct: 593 KQIEQKFAQIDEKT----EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
Query: 290 MEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKE 349
EEE R +E + + + ++RL KA E K E
Sbjct: 649 QEEEERRHQELLQKKKEEEQERL------RKAAEAKRLAE-------------------- 682
Query: 350 YENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQ 402
Q + +++ + ++++ E +R+ + Q+ + + ++ EQ++LQ
Sbjct: 683 -------QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 728
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 54.7 bits (130), Expect = 2e-07
Identities = 94/418 (22%), Positives = 174/418 (41%), Gaps = 70/418 (16%)
Query: 18 LLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQK 77
L ALE+ + I++ +NI ++ K KQV LE K ++ K
Sbjct: 74 LAVALESSSVTINQLN-ENIESLKQQK--------------KQVEHQLEEAKKTNNEIHK 118
Query: 78 ADIEEIKSGRLS--KELDLVSHHVRTK-----LDELKRQEVGRLRMLIKAKLD------- 123
A +E++++ + ++ DL + TK +E + GRL+ ++ +
Sbjct: 119 AQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSA 178
Query: 124 -SLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFK--KY 180
S Q D + ++ L E L+ + T L+ R E K K
Sbjct: 179 VSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKG 238
Query: 181 EMMKEHERREYL----KTLNEEKRK------EEESKFEEMKKKHENHPKVNHPGS----- 225
E + ER + +TL EEK++ E E E+K + P + P
Sbjct: 239 ERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVE 298
Query: 226 --KDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNE 283
+D+ K + +E +GL+ KL ++ + +L +KE ++ + +
Sbjct: 299 QLQDEAKHLRQEVEGLEG---------KLQSQ-----VENNQALSLLSKEQKQRL--QEQ 342
Query: 284 EDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFT 343
E+ + E E +R+R +E + + + +++ TL+E + K+E E L ++
Sbjct: 343 EEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKE---- 398
Query: 344 EEELKEYENIIALQENELKKKADELQKQKEELQ-RQHDQLEAQKLEYHQVIQQMEQKK 400
EE L++ E + QE L KK + LQKQ+E L Q+ +L+ Q E + + +K
Sbjct: 399 EERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEK 456
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 54.3 bits (129), Expect = 2e-07
Identities = 94/418 (22%), Positives = 174/418 (41%), Gaps = 70/418 (16%)
Query: 18 LLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQK 77
L ALE+ + I++ +NI ++ K KQV LE K ++ K
Sbjct: 74 LAVALESSSVTINQLN-ENIESLKQQK--------------KQVEHQLEEAKKTNNEIHK 118
Query: 78 ADIEEIKSGRLS--KELDLVSHHVRTK-----LDELKRQEVGRLRMLIKAKLD------- 123
A +E++++ + ++ DL + TK +E + GRL+ ++ +
Sbjct: 119 AQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQHIQELERALCA 178
Query: 124 -SLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFK--KY 180
S Q D + ++ L E L+ + T L+ R E K K
Sbjct: 179 VSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKG 238
Query: 181 EMMKEHERREYL----KTLNEEKRK------EEESKFEEMKKKHENHPKVNHPGS----- 225
E + ER + +TL EEK++ E E E+K + P + P
Sbjct: 239 ERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVE 298
Query: 226 --KDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNE 283
+D+ K + +E +GL+ KL ++ + +L +KE ++ + +
Sbjct: 299 QLQDEAKHLRQEVEGLEG---------KLQSQ-----VENNQALSLLSKEQKQRL--QEQ 342
Query: 284 EDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFT 343
E+ + E E +R+R +E + + + +++ TL+E + K+E E L ++
Sbjct: 343 EEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKE---- 398
Query: 344 EEELKEYENIIALQENELKKKADELQKQKEELQ-RQHDQLEAQKLEYHQVIQQMEQKK 400
EE L++ E + QE L KK + LQKQ+E L Q+ +L+ Q E + + +K
Sbjct: 399 EERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEK 456
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 53.5 bits (127), Expect = 3e-07
Identities = 80/335 (23%), Positives = 145/335 (43%), Gaps = 41/335 (12%)
Query: 71 FREKLQKADIEEIKS-------GRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLD 123
++E+L K + E K G L +EL+ + + + +E G+ + K L+
Sbjct: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLE 1832
Query: 124 SLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMM 183
++ D D Q L++ + + K + D ++ + +E + T +++K + +
Sbjct: 1833 NVFD---DVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELT--SKYEKLQAL 1887
Query: 184 KEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPND 243
++ + R L EE EE+SK ++ K ++ + H + +L E L
Sbjct: 1888 QQMDGRNKPTELLEENT-EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG--- 1943
Query: 244 FDPKTFFKLH-DVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLR------ 296
K +L D+ +QELE L +K YD + EE E E+ L+
Sbjct: 1944 ---KEIVRLQKDLRMLRKEHQQELEIL-----KKEYDQEREEKIKQEQEDLELKHNSTLK 1995
Query: 297 --MREHVMNEVDTNKDRLVTLEEFL-KATE-KKEFLEPDSWETLDQQQFFTEEE------ 346
MRE ++ +T++E + KA E + E LE ET + E++
Sbjct: 1996 QLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRT 2055
Query: 347 LKEYENIIALQENELKKKADELQKQKEELQRQHDQ 381
K YE I+ +E E+ K +LQ Q EELQ+++ Q
Sbjct: 2056 AKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
Score = 47.8 bits (112), Expect = 2e-05
Identities = 85/381 (22%), Positives = 153/381 (40%), Gaps = 73/381 (19%)
Query: 59 KQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLV---SHHVRTKLDELKRQEVGRLR 115
K++I ++ + L+K D+++ + LS EL V H + +L LK Q +++
Sbjct: 660 KEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ-TDKMK 718
Query: 116 MLIKAKLDSLQD----------------IGMDHQALLKQFDHLN--------HLNPDKFE 151
++AK+D ++ I +AL Q + L HL +
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778
Query: 152 STDLDMLIKAATSDLEH----------YDKTRHEEFKKYEMMKEHERREYLKTLNEEKRK 201
+L+ IK + +L+ Y HE+ K YE E L L ++
Sbjct: 779 VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE--------EQLAQLQQKLLD 830
Query: 202 EEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFL 261
E + K+ E + Q K+V E D D +L NS+
Sbjct: 831 LETERILLTKQVAE---------VEAQKKDVCTELDAHKIQVQD--LMQQLEKQNSEM-- 877
Query: 262 DEQELEALFTKELEKVYDPKNEEDD----MVEMEEERLRMREHVMNEVDTNKDRLVTLEE 317
EQ++++L K+ D E++ +VE E L+MRE E++ L +
Sbjct: 878 -EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI-------LTQ 929
Query: 318 FLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQR 377
L A E + + +ET + Q E++K+ +QE KK D+ K K+EL+
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK--EMQETLKKKLLDQEAKLKKELEN 987
Query: 378 QHDQLEAQKLEYHQVIQQMEQ 398
+L ++ +++ + +M Q
Sbjct: 988 TALELSQKEKQFNAKMLEMAQ 1008
Score = 44.7 bits (104), Expect = 2e-04
Identities = 74/333 (22%), Positives = 142/333 (42%), Gaps = 55/333 (16%)
Query: 99 VRTKLDELKRQE--VGRLRMLIKAKLDSLQDIGMDHQALLKQFDH-LNHLNPDK----FE 151
+ T +KRQE + R + I++ + + + +AL +Q D L L K E
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 152 STDLDMLIKAATSDLEHYDKTR-----------HE--EFKKYEMMKEHERREYLKT---- 194
T L ++ A + +E ++ + HE E K+ E+ + R + + T
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 195 LNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHD 254
L E+K K E + FEE++K K ++ +LK +E KT K +
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEE--ARRKLKAEMDE---------QIKTIEKTSE 449
Query: 255 VNSDGFLDEQELEALFTKELEKVYDPKNEED--DMVEMEEERLRMREHVMNEVDTNKDRL 312
+ +QEL + +E+ V +EE + ++ E+ L +E + + ++R
Sbjct: 450 --EERISLQQELSRV-KQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER- 505
Query: 313 VTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKA--DELQK 370
+E +K +K Q ++ + KE + +AL+E EL+KKA E +
Sbjct: 506 -EFQEQMKVALEK-----------SQSEYLKISQEKEQQESLALEELELQKKAILTESEN 553
Query: 371 QKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
+ +LQ++ + + LE +++ Q+ Q
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Score = 43.5 bits (101), Expect = 4e-04
Identities = 69/363 (19%), Positives = 161/363 (44%), Gaps = 31/363 (8%)
Query: 56 EYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLR 115
E L++ + + + R KL+ E+IK+ + E + +S ++ +L +K++ V ++
Sbjct: 414 EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERIS--LQQELSRVKQEVVDVMK 471
Query: 116 MLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHE 175
+ ++ LQ + + L ++ L + M + S E+ ++ +
Sbjct: 472 KSSEEQIAKLQKL--HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529
Query: 176 EFKKYEMMKEHE-RREYLKTLNEEKRKEEESKFE-------EMKKKHENHPKVNHPGSKD 227
E ++ ++E E +++ + T +E K ++ + + E E++ E + N SKD
Sbjct: 530 EQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKD 589
Query: 228 QLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDM 287
+ E + ++ + + H + +Q+ AL+T++L+ + ++
Sbjct: 590 LAVHLEAEKN---KHNKEITVMVEKHKTELESLKHQQD--ALWTEKLQVL-----KQQYQ 639
Query: 288 VEMEEERLRMREHVMNEVDTN-KDRLVTLEEFLKATEKKEFLEPDSWET-LDQQQFFTEE 345
EME ++RE E +T KD+ + + ++ +K + D +T L+ E
Sbjct: 640 TEME----KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSE 695
Query: 346 ELK---EYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQ 402
LK + E +++ +++ K EL+ + +E + H Q ++ H+V Q +K L+
Sbjct: 696 VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 403 QGI 405
I
Sbjct: 756 DQI 758
Score = 42.4 bits (98), Expect = 8e-04
Identities = 98/423 (23%), Positives = 172/423 (40%), Gaps = 77/423 (18%)
Query: 16 TCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKL 75
T L LE + +D++K+ +N E + + +E ++V ++ K E+
Sbjct: 1130 TKLKAHLEKLEVDLNKSLKENTFLQEQLV----ELKMLAEEDKRKVSELTSKLKTTDEEF 1185
Query: 76 QKADIEEIKSGRL----SKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMD 131
Q KS + S E +S + +LD + + L++AK + L +I
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK----KTEALLEAKTNELINISSS 1241
Query: 132 H-QALLKQFDHLNHLNPDKFESTDLDMLIKAAT-SDLE---------------HYDKTRH 174
A+L + H H E+ +LIK T S+LE + + H
Sbjct: 1242 KTNAILSRISHCQHRTTKVKEA----LLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
Query: 175 EEFKKYEMMKEHERR-EYLKTLNEEKRKE----------EESKFEEMKKK-HENHPKVNH 222
+ +K +K + E L T E +KE +ES ++KK+ EN V
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
Query: 223 PGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKN 282
K++LKE E L D +V + E EA + L K YD
Sbjct: 1358 --MKEELKEKKVEISSLSKQLTDL-------NVQLQNSISLSEKEAAISS-LRKQYD--- 1404
Query: 283 EEDDMVEMEEERLRMREHVMN---EVDT-NKDRLVTLEEFLKATEKKEFLEPDSWETLDQ 338
EE+ + + V + +VDT +K+++ LE+ + K F E W+ Q
Sbjct: 1405 ---------EEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK--FSE---WKKKAQ 1450
Query: 339 QQFFTEEE-LKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQME 397
+F + +KE + + L+ E +K +++ KEEL +Q+ + + K E +ME
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKME 1510
Query: 398 QKK 400
+K+
Sbjct: 1511 KKE 1513
Score = 40.8 bits (94), Expect = 0.002
Identities = 78/350 (22%), Positives = 134/350 (38%), Gaps = 70/350 (20%)
Query: 65 LETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDS 124
+E DK EK + E+KS + ++ ++L H + K E+ L ++K +
Sbjct: 1502 MEDDKSKMEKKESNLETELKS-QTARIMELEDHITQ------KTIEIESLNEVLK---NY 1551
Query: 125 LQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEM-- 182
Q ++H+ L+++ H L +K ++ + K T + + Y E KK E+
Sbjct: 1552 NQQKDIEHKELVQKLQHFQELGEEK-DNRVKEAEEKILTLENQVYSMKAELETKKKELEH 1610
Query: 183 --MKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLD 240
+ + E LK L + E +K E+K+K E K QL EE +
Sbjct: 1611 VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ----KIAAIKKQLLSQMEEKE--- 1663
Query: 241 PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREH 300
+ T L ++N+ L E+E E V + EE+L+ E
Sbjct: 1664 -EQYKKGTESHLSELNTK--LQERERE--------------------VHILEEKLKSVES 1700
Query: 301 VMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE 360
+E L+ E E DS + K YE I++ +
Sbjct: 1701 SQSET------LIVPRSAKNVAAYTEQEEADSQGCVQ----------KTYEEKISVLQRN 1744
Query: 361 LKKKADELQK---QKEELQRQHDQLEAQ------KLEYHQVIQQMEQKKL 401
L +K LQ+ +KEE H ++ Q KLE+ + Q +Q +
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Score = 40.0 bits (92), Expect = 0.004
Identities = 92/421 (21%), Positives = 170/421 (40%), Gaps = 69/421 (16%)
Query: 4 RTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVE----SAKIEPPDTGLYYDEYLK 59
RT ++ L+ TC ++ LEA + T+ QN + + ++E + + + +K
Sbjct: 1256 RTTKVKEALLIKTCTVSELEAQLRQL--TEEQNTLNISFQQATHQLEEKENQI---KSMK 1310
Query: 60 QVIDVLETDKHFREK-----LQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRL 114
I+ L T+K +K Q A +E +L KEL + V +ELK ++V +
Sbjct: 1311 ADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKV-EI 1369
Query: 115 RMLIKAKLD---------SLQDIGMDHQALLKQFDHLNHLNPDKFE--STDLDMLIKAAT 163
L K D SL + +L KQ+D D+ + S +D L K
Sbjct: 1370 SSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
Query: 164 SDLEHYD--KTRHEEFKKYEMMKEHERREYLKTLN---EEKRKEEESKFEEMKKKHENHP 218
S LE D + E+KK + + + +K L E K KE K E++
Sbjct: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL----- 1484
Query: 219 KVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVY 278
K++L + + D L D K+ + + N + L Q + ELE
Sbjct: 1485 -------KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM---ELEDHI 1534
Query: 279 DPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQ 338
K +E+E ++ + + +K+ + L+ F + E+K+
Sbjct: 1535 TQKT-----IEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKD------------ 1577
Query: 339 QQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQ 398
+KE E I EN++ EL+ +K+EL+ + +++++ E + ++E
Sbjct: 1578 ------NRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 399 K 399
+
Sbjct: 1632 E 1632
Score = 34.7 bits (78), Expect = 0.17
Identities = 35/145 (24%), Positives = 67/145 (46%), Gaps = 10/145 (6%)
Query: 262 DEQELEALFTKELEKVYDPKNEEDDM------VEMEEERLRMREHVMNEVDTNKDRLVTL 315
+E +++ K L++ +D EE D ++ + R+R MN VD K L L
Sbjct: 194 EELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMN-VDVLKP-LPQL 251
Query: 316 EEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEEL 375
E + K+E E D ++ + + L+ + + QEN LK+ + +Q KE+
Sbjct: 252 EPQAEVFTKEENPESDGEPVVEDGT--SVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309
Query: 376 QRQHDQLEAQKLEYHQVIQQMEQKK 400
+ EA + + + +Q++E+ K
Sbjct: 310 TLLTSEKEALQEQLDERLQELEKIK 334
Score = 33.9 bits (76), Expect = 0.28
Identities = 79/388 (20%), Positives = 164/388 (42%), Gaps = 78/388 (20%)
Query: 33 KVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKE- 91
KV+++ V +K+E G E KQ++ E + QK +IE + +KE
Sbjct: 880 KVKSLTQVYESKLED---GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936
Query: 92 -LDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLN---- 146
+ +++ TK + +++ +++ K ++L+ +D +A LK+ L
Sbjct: 937 SIHILNEEYETKFKN-QEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK 995
Query: 147 PDKFESTDLDML------IKAATSDLEHYDKTRHE---EFKKYEM--------MKEHERR 189
+F + L+M I A S LE K + E E + E+ K +++
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 190 EYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQL-KEVWEETDGLDPNDFDPKT 248
E L+ ++E + +E+E + E+K+K + K+++ KE+ T
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQK-----ILLFGCEKEEMNKEI---------------T 1095
Query: 249 FFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTN 308
+ K V D L+ EL++ K+ + + +E +L+ + EVD N
Sbjct: 1096 WLKEEGVKQDTTLN----------ELQEQLKQKSAHVNSLAQDETKLKAHLEKL-EVDLN 1144
Query: 309 KDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADEL 368
K+ ++ FL+ E L + + EE+ ++ + ++LK +E
Sbjct: 1145 -----------KSLKENTFLQ----EQLVELKMLAEEDKRKVSEL----TSKLKTTDEEF 1185
Query: 369 QKQKEELQRQHDQLEAQKLEYHQVIQQM 396
Q K ++ + LE + LE+ ++ +++
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Score = 30.0 bits (66), Expect = 4.1
Identities = 50/229 (21%), Positives = 98/229 (42%), Gaps = 24/229 (10%)
Query: 181 EMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLD 240
++ K + +E + E+K KE +S K+ H ++L +E+ L
Sbjct: 1837 DVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVE--------MEELTSKYEKLQALQ 1888
Query: 241 PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNE-EDDMVEMEEERLRMRE 299
D K +L + N++ ++ + + K L + N+ E + E E+ ++ +
Sbjct: 1889 QMDGRNKPT-ELLEENTE---EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGK 1944
Query: 300 HVMNEVDTNKDRLVTLEEFLKATE--KKEFLEPDSWETLDQQQFFTEEELKEYENIIALQ 357
+ V KD + +E + E KKE+ + + E + Q+Q + ELK + L
Sbjct: 1945 EI---VRLQKDLRMLRKEHQQELEILKKEY-DQEREEKIKQEQ--EDLELKHNSTLKQLM 1998
Query: 358 EN---ELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ 403
+L +K EL+ +E + ++EA+ LE HQ KK+ +
Sbjct: 1999 REFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAE 2047
>gi|110815815 centlein isoform 1 [Homo sapiens]
Length = 1406
Score = 53.5 bits (127), Expect = 3e-07
Identities = 78/289 (26%), Positives = 123/289 (42%), Gaps = 60/289 (20%)
Query: 160 KAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTL-NEEKRKEEESKFEEMKKKHENHP 218
K++ +D E K R E K ++ E+ LK+ N+E R E + E ++ N+
Sbjct: 519 KSSFTDSEELQKLRKAERK----IENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYR 574
Query: 219 KVNHPGSKDQLKEVWEETDGL---------DPND---------FDPKTFFK-------LH 253
V K+QLK+ WEE G+ DP ++ +FK +
Sbjct: 575 AV-----KEQLKQ-WEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQ 628
Query: 254 DVNSDGFLDEQELEALFTK----ELEKVYDPKNEE-------DDMVEM---EEERLRMRE 299
+N + LDE ++ K EL + + EE DD V+ E+ M E
Sbjct: 629 KMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLE 688
Query: 300 HVMNEVDTNKDRLVTLEEF---LKATEKKEFLEPDSWETL-DQQQFFTEEELKEYENIIA 355
+ +V ++RL + E+ LK KK E D ++L QQQ TE KE E II
Sbjct: 689 QTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIK 748
Query: 356 ------LQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQ 398
+ EL+ K EL+ + L+RQ + A + E ++I ME+
Sbjct: 749 GSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEK 797
Score = 29.6 bits (65), Expect = 5.4
Identities = 44/223 (19%), Positives = 90/223 (40%), Gaps = 18/223 (8%)
Query: 178 KKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETD 237
++ + E + R+ L+ L + K +E + E K E + V + D+ +
Sbjct: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK-- 206
Query: 238 GLDPNDFDPKTFFKLHDVNS--DGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERL 295
+ +D + K K ++ + +++E L K LE+ + + + E+L
Sbjct: 207 --EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKL 264
Query: 296 RMRE-HVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENII 354
R +E H+ E + ++ T E+ L K+ + + L Q + EL + + I
Sbjct: 265 RKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDI 324
Query: 355 ALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQME 397
L EL +ELQ + Q + ++IQQ++
Sbjct: 325 TLVRKEL-----------QELQNLYKQNSTHTAQQAELIQQLQ 356
Score = 29.3 bits (64), Expect = 7.0
Identities = 45/234 (19%), Positives = 99/234 (42%), Gaps = 29/234 (12%)
Query: 159 IKAATSDLEHYDKTRHEEFKKYEMMKE---HER----------REYLKTLNEEKRKEEES 205
++ S L++ KT K+Y+ + E H++ R+ +K LN + +
Sbjct: 991 LQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKE 1050
Query: 206 KFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPN---DFDPKTF-FKLHDVNSDGFL 261
K + +KK + + Q+ + L P+ D + K +KL + ++
Sbjct: 1051 KEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTK 1110
Query: 262 DEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEV--------DTNK---D 310
++ L + L K K + + ME + + M+ H++ ++ ++NK +
Sbjct: 1111 QSSNVKTLKFELLAKEEHIKEMHEKISRMERD-ITMKRHLIEDLKFRQKVNLESNKSFSE 1169
Query: 311 RLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKK 364
L L++ +K ++ + S ++L Q+ +E +YE + + EL+KK
Sbjct: 1170 MLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKK 1223
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 52.8 bits (125), Expect = 6e-07
Identities = 83/395 (21%), Positives = 167/395 (42%), Gaps = 62/395 (15%)
Query: 49 DTGLYYDEYLKQVIDVLETDKHFREKLQKADIEEIKS-----GRLSKELDLVSHHVRTKL 103
D L +L + V +D H++E L+ +D+E + +L KE + + +
Sbjct: 65 DPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTE 124
Query: 104 DELKRQE--VGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKA 161
EL+++E + R +I+A+ ++Q++ ++ + + + N D + + +
Sbjct: 125 AELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNAT---RH 181
Query: 162 ATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVN 221
+ L+ E+ KKYE +E R+ Y+ N ++ + FEE++ + EN
Sbjct: 182 LCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMI--TAFEELRVQAENSRLEM 239
Query: 222 HPGSKDQLKEVWEETDGLDP------NDFDPKTFFKLHDVNSDGFLDEQELEALFTKELE 275
H +LKE +E+ L+ ND + + L + E +++ L T LE
Sbjct: 240 H----FKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEK----ENKMKDL-TFLLE 290
Query: 276 KVYDPKNEEDDMVEMEEERLRM----REHVMNEVDTNK---------------DRLVTLE 316
+ D N+ ++ +++ E L+ + H+ E++ K D + +
Sbjct: 291 ESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATK 350
Query: 317 EFLKATEKKEFLEPDSWETLDQQQFFT----------EEELKEYENIIALQENELKKKAD 366
+ TE+KE +S + F EE L+ + + E++LK
Sbjct: 351 TICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTM 410
Query: 367 ELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKL 401
ELQK+ EL+ E KL ++ ++ E KK+
Sbjct: 411 ELQKKSSELE------EMTKLTNNKEVELEELKKV 439
Score = 47.8 bits (112), Expect = 2e-05
Identities = 78/373 (20%), Positives = 158/373 (42%), Gaps = 42/373 (11%)
Query: 56 EYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLR 115
E LK+V+ ET + ++ +K EE+K E +L+ L + + +EV L
Sbjct: 434 EELKKVLGEKETLLYENKQFEKI-AEELKG----TEQELIG------LLQAREKEVHDLE 482
Query: 116 MLIKAKLDSLQDIGMDHQALLKQFD-----------HLNHLNPDKFEST----DLDMLIK 160
+ + A S Q + + L + + H N L+ + E T D+ + +K
Sbjct: 483 IQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELK 542
Query: 161 AATSDLEHYDKTRHEEFKKYEMMKEHERR-----EYLKTLNEEKRKEEESKFEEMKKKHE 215
D+ + K K+ E ++E E + EY++ ++KR E + K ++ ++
Sbjct: 543 NQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCN 602
Query: 216 NHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTK--E 273
N K +K ++E+ +E L ++++ + E ELE+ K E
Sbjct: 603 NLRKQVENKNK-YIEELQQENKALKKKGTAESKQLNVYEIKVNKL--ELELESAKQKFGE 659
Query: 274 LEKVYDPK------NEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEF 327
+ Y + +EE+ + E+E+ ++ E V + + +K + E + EK +
Sbjct: 660 ITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKH 719
Query: 328 LEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKL 387
E D + + + +E ++ A E EL EL K++L+ + ++ E K
Sbjct: 720 QYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKR 779
Query: 388 EYHQVIQQMEQKK 400
E + +++KK
Sbjct: 780 EAKENTATLKEKK 792
Score = 32.7 bits (73), Expect = 0.63
Identities = 49/226 (21%), Positives = 99/226 (43%), Gaps = 32/226 (14%)
Query: 23 EAVPIDIDKTKVQNIH-PVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKADIE 81
E+ +++ + KV + +ESAK + G D Y K++ D ++++ E+++KA +
Sbjct: 632 ESKQLNVYEIKVNKLELELESAKQK---FGEITDTYQKEIEDKKISEENLLEEVEKAKVI 688
Query: 82 EIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDH 141
++ +L KE+D H ++ L + + +I+ + DS ++G+ +Q
Sbjct: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEER-DS--ELGLYKSKEQEQSSL 745
Query: 142 LNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRK 201
L + E ++L + + LE ++ E+ K+ E +E TL E+K K
Sbjct: 746 RASL---EIELSNLKAELLSVKKQLE-IEREEKEKLKR-------EAKENTATLKEKKDK 794
Query: 202 EE--------------ESKFEEMKKKHENHPKVNHPGSKDQLKEVW 233
+ +SK + N V+H SKD+ +W
Sbjct: 795 KTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLW 840
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 52.8 bits (125), Expect = 6e-07
Identities = 86/377 (22%), Positives = 158/377 (41%), Gaps = 55/377 (14%)
Query: 59 KQVIDVLETDKHFREKLQKADIEEIKSGRLS--KELDLVSHHVRTK-----LDELKRQEV 111
KQV LE K ++ KA +E +++ + ++ DL + TK +E +
Sbjct: 100 KQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKRAARHFEEESKDLA 159
Query: 112 GRLRMLIKAKLD--------SLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAAT 163
GRL+ ++ + S Q D + ++ L E L+ + T
Sbjct: 160 GRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQQTIKERALLNAHVTQVT 219
Query: 164 SDLEHYDKTRHEEFK--KYEMMKEHERREYL----KTLNEEKRK------EEESKFEEMK 211
L+ R E K K E + ER + +TL EEK++ E E E+K
Sbjct: 220 ESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELK 279
Query: 212 KKHENHPKVNHPGS-------KDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQ 264
+ P + P +D+ K + +E +GL+ KL ++
Sbjct: 280 NQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEG---------KLQSQ-----VENN 325
Query: 265 ELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEK 324
+ +L +KE ++ + +E+ + E E +R+R +E + + + +++ TL+E + K
Sbjct: 326 QALSLLSKEQKQRL--QEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRK 383
Query: 325 KEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQ-RQHDQLE 383
+E E L ++ EE L++ E + QE L KK + LQKQ+E L Q+ +L+
Sbjct: 384 QEQRLRKQEERLRKE----EERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLD 439
Query: 384 AQKLEYHQVIQQMEQKK 400
Q E + + +K
Sbjct: 440 KQLAEPQCSFEDLNNEK 456
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,634,802
Number of Sequences: 37866
Number of extensions: 822637
Number of successful extensions: 13953
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 374
Number of HSP's successfully gapped in prelim test: 937
Number of HSP's that attempted gapping in prelim test: 6430
Number of HSP's gapped (non-prelim): 4958
length of query: 420
length of database: 18,247,518
effective HSP length: 105
effective length of query: 315
effective length of database: 14,271,588
effective search space: 4495550220
effective search space used: 4495550220
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.