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Search of human proteins with 132626790
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|132626790 low density lipoprotein receptor adaptor protein 1
[Homo sapiens]
(308 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|132626790 low density lipoprotein receptor adaptor protein 1 ... 611 e-175
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 88 8e-18
gi|54144629 numb homolog isoform 4 [Homo sapiens] 77 1e-14
gi|20070356 numb homolog isoform 3 [Homo sapiens] 77 1e-14
gi|54144627 numb homolog isoform 2 [Homo sapiens] 74 1e-13
gi|54144625 numb homolog isoform 1 [Homo sapiens] 74 1e-13
gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein i... 74 2e-13
gi|10863899 numb homolog (Drosophila)-like [Homo sapiens] 70 3e-12
gi|33350928 disabled homolog 1 [Homo sapiens] 62 8e-10
gi|50511947 cajalin 2 isoform b [Homo sapiens] 58 1e-08
gi|50511945 cajalin 2 isoform a [Homo sapiens] 58 1e-08
gi|10047134 cajalin 2 isoform c [Homo sapiens] 58 1e-08
gi|31377557 hypothetical protein LOC131583 [Homo sapiens] 57 2e-08
gi|148491082 disabled homolog 2 [Homo sapiens] 55 1e-07
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 53 4e-07
gi|46409306 family with sequence similarity 43, member B [Homo s... 49 6e-06
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 44 1e-04
gi|4885433 mitogen-activated protein kinase 8 interacting protei... 41 0.002
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 38 0.010
gi|169790811 SHC (Src homology 2 domain containing) transforming... 38 0.010
gi|50083291 amyloid beta A4 precursor protein-binding, family B,... 36 0.049
gi|154816208 phosphotyrosine interaction domain containing 1 iso... 35 0.064
gi|40255260 phosphotyrosine interaction domain containing 1 isof... 35 0.064
gi|169211037 PREDICTED: similar to mitogen-activated protein kin... 35 0.11
gi|222446609 rai-like protein [Homo sapiens] 34 0.14
gi|239740950 PREDICTED: similar to mitogen-activated protein kin... 34 0.14
gi|11342678 amyloid beta (A4) precursor protein-binding, family ... 33 0.42
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 32 0.54
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 31 1.2
gi|139394599 hypermethylated in cancer 2 [Homo sapiens] 31 1.6
>gi|132626790 low density lipoprotein receptor adaptor protein 1
[Homo sapiens]
Length = 308
Score = 611 bits (1575), Expect = e-175
Identities = 308/308 (100%), Positives = 308/308 (100%)
Query: 1 MDALKSAGRALIRSPSLAKQSWGGGGRHRKLPENWTDTRETLLEGMLFSLKYLGMTLVEQ 60
MDALKSAGRALIRSPSLAKQSWGGGGRHRKLPENWTDTRETLLEGMLFSLKYLGMTLVEQ
Sbjct: 1 MDALKSAGRALIRSPSLAKQSWGGGGRHRKLPENWTDTRETLLEGMLFSLKYLGMTLVEQ 60
Query: 61 PKGEELSAAAIKRIVATAKASGKKLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCT 120
PKGEELSAAAIKRIVATAKASGKKLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCT
Sbjct: 61 PKGEELSAAAIKRIVATAKASGKKLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCT 120
Query: 121 ADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKE 180
ADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKE
Sbjct: 121 ADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKE 180
Query: 181 KRDKASQEGGDVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVSANTTNMDEVPRPQ 240
KRDKASQEGGDVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVSANTTNMDEVPRPQ
Sbjct: 181 KRDKASQEGGDVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVSANTTNMDEVPRPQ 240
Query: 241 ALSGSSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLTAQDMHYAQCLSPVDWDKPDSSGT 300
ALSGSSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLTAQDMHYAQCLSPVDWDKPDSSGT
Sbjct: 241 ALSGSSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLTAQDMHYAQCLSPVDWDKPDSSGT 300
Query: 301 EQDDLFSF 308
EQDDLFSF
Sbjct: 301 EQDDLFSF 308
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 88.2 bits (217), Expect = 8e-18
Identities = 50/159 (31%), Positives = 89/159 (55%), Gaps = 7/159 (4%)
Query: 29 RKLPENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIVATA---KASGKK 84
RK + W T E L + + ++ K+LG T VEQPKG E+ A++++ K+ G+K
Sbjct: 7 RKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQK 66
Query: 85 LQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECH 144
+ KV L++S G+ + + T ++ N ++RIS+C DK ++F +I + + C+
Sbjct: 67 IPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCY 126
Query: 145 AFLCTKRKMAQAVTLTVAQAFKVAF-EFWQVSKEEKEKR 182
F K A+ +TLT+ QAF +A+ +F + ++ E R
Sbjct: 127 VF--DSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETR 163
>gi|54144629 numb homolog isoform 4 [Homo sapiens]
Length = 592
Score = 77.4 bits (189), Expect = 1e-14
Identities = 63/236 (26%), Positives = 103/236 (43%), Gaps = 32/236 (13%)
Query: 32 PENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTL 90
P W E + G F +KYLG V++ +G + A+KR+ KA+GKK K L
Sbjct: 22 PHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRL----KATGKKAVKAVL 77
Query: 91 KVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTK 150
VS G+ + D T LI + +I ++S+C D+ D+ F+YI + + CH F+ K
Sbjct: 78 WVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVK 137
Query: 151 RKMAQAVTLTVAQAFKVAFEFWQVSKEEKE---------KRDKASQEGG----------- 190
+ ++ V AF E + K EKE R ++EG
Sbjct: 138 -DTGERLSHAVGCAFAACLE--RKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAE 194
Query: 191 --DVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVS--ANTTNMDEVPRPQAL 242
+++ QD + + G+ + TA +P S S ++ T E+ P A+
Sbjct: 195 REEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAI 250
>gi|20070356 numb homolog isoform 3 [Homo sapiens]
Length = 640
Score = 77.4 bits (189), Expect = 1e-14
Identities = 63/236 (26%), Positives = 103/236 (43%), Gaps = 32/236 (13%)
Query: 32 PENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTL 90
P W E + G F +KYLG V++ +G + A+KR+ KA+GKK K L
Sbjct: 22 PHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRL----KATGKKAVKAVL 77
Query: 91 KVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTK 150
VS G+ + D T LI + +I ++S+C D+ D+ F+YI + + CH F+ K
Sbjct: 78 WVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVK 137
Query: 151 RKMAQAVTLTVAQAFKVAFEFWQVSKEEKE---------KRDKASQEGG----------- 190
+ ++ V AF E + K EKE R ++EG
Sbjct: 138 -DTGERLSHAVGCAFAACLE--RKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAE 194
Query: 191 --DVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVS--ANTTNMDEVPRPQAL 242
+++ QD + + G+ + TA +P S S ++ T E+ P A+
Sbjct: 195 REEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAI 250
>gi|54144627 numb homolog isoform 2 [Homo sapiens]
Length = 603
Score = 74.3 bits (181), Expect = 1e-13
Identities = 63/243 (25%), Positives = 103/243 (42%), Gaps = 35/243 (14%)
Query: 32 PENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIVATAK-------ASGK 83
P W E + G F +KYLG V++ +G + A+KR+ A K +GK
Sbjct: 22 PHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGK 81
Query: 84 KLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLEC 143
K K L VS G+ + D T LI + +I ++S+C D+ D+ F+YI + + C
Sbjct: 82 KAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWIC 141
Query: 144 HAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKE---------KRDKASQEGG---- 190
H F+ K + ++ V AF E + K EKE R ++EG
Sbjct: 142 HCFMAVK-DTGERLSHAVGCAFAACLE--RKQKREKECGVTATFDASRTTFTREGSFRVT 198
Query: 191 ---------DVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVS--ANTTNMDEVPRP 239
+++ QD + + G+ + TA +P S S ++ T E+ P
Sbjct: 199 TATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNP 258
Query: 240 QAL 242
A+
Sbjct: 259 HAI 261
>gi|54144625 numb homolog isoform 1 [Homo sapiens]
Length = 651
Score = 74.3 bits (181), Expect = 1e-13
Identities = 63/243 (25%), Positives = 103/243 (42%), Gaps = 35/243 (14%)
Query: 32 PENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIVATAK-------ASGK 83
P W E + G F +KYLG V++ +G + A+KR+ A K +GK
Sbjct: 22 PHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGK 81
Query: 84 KLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLEC 143
K K L VS G+ + D T LI + +I ++S+C D+ D+ F+YI + + C
Sbjct: 82 KAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWIC 141
Query: 144 HAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKE---------KRDKASQEGG---- 190
H F+ K + ++ V AF E + K EKE R ++EG
Sbjct: 142 HCFMAVK-DTGERLSHAVGCAFAACLE--RKQKREKECGVTATFDASRTTFTREGSFRVT 198
Query: 191 ---------DVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVS--ANTTNMDEVPRP 239
+++ QD + + G+ + TA +P S S ++ T E+ P
Sbjct: 199 TATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNP 258
Query: 240 QAL 242
A+
Sbjct: 259 HAI 261
>gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein
isoform 1 [Homo sapiens]
Length = 506
Score = 73.9 bits (180), Expect = 2e-13
Identities = 83/307 (27%), Positives = 126/307 (41%), Gaps = 44/307 (14%)
Query: 15 PSLAKQSWGGGGRHRKLPENWTDTRETLLEGMLFSLKYLGMTLVEQPKGEELSAAAIKRI 74
PS K + G ++P + D + G+ F KY+G V +P AA++RI
Sbjct: 2 PSKTKYNLVDDGHDLRIPLHNEDAFQ---HGICFEAKYVGSLDVPRPNSRVEIVAAMRRI 58
Query: 75 VATAKASGKKLQKVTLKVSPRGIIL----------------TDNLTNQLIENVSIYRISY 118
KA K +KV++ VS G+ + T + + L+ IYRI Y
Sbjct: 59 RYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFY 118
Query: 119 CTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEE 178
+ D K+F+YIA+ + C+ F K+ A + TV QAF+V ++S +
Sbjct: 119 VSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCH---KLSLQH 175
Query: 179 KEKRDKASQEGGDVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVSANTTNMD--EV 236
++ ++G + P G L E A ST +A T++D EV
Sbjct: 176 TQQNADGQEDGESERNSNSSGDP--------GRQLTGAERA----STATAEETDIDAVEV 223
Query: 237 PRP--QALSGSSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLTAQDMHYAQCLSPVDWDK 294
P P L S V +LD E S ++PQ + LTA + L P K
Sbjct: 224 PLPGNDVLEFSRGVTDLDAVGKEGGSHTGSKVSHPQ--EPMLTAS----PRMLLPSSSSK 277
Query: 295 PDSSGTE 301
P GTE
Sbjct: 278 PPGLGTE 284
>gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]
Length = 609
Score = 69.7 bits (169), Expect = 3e-12
Identities = 45/150 (30%), Positives = 75/150 (50%), Gaps = 8/150 (5%)
Query: 32 PENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTL 90
P W + + +G F ++YLG VE+ +G + A+K++ KA G+K K L
Sbjct: 63 PHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKL----KAMGRKSVKSVL 118
Query: 91 KVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTK 150
VS G+ + D+ T L+ + +I ++S+C D+ DK F+YI + + CH FL K
Sbjct: 119 WVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALK 178
Query: 151 RKMAQAVTLTVAQAFKVAFEFWQVSKEEKE 180
+ ++ V AF E + + EKE
Sbjct: 179 -DSGERLSHAVGCAFAACLE--RKQRREKE 205
>gi|33350928 disabled homolog 1 [Homo sapiens]
Length = 555
Score = 61.6 bits (148), Expect = 8e-10
Identities = 42/150 (28%), Positives = 77/150 (51%), Gaps = 10/150 (6%)
Query: 44 EGMLFSLKYLGMTLVEQPKGEEL---SAAAIKRIVATAKASGKKLQKVTLKVSPRGIILT 100
EG+ + K +G+ V +G++L S +K +VA A++ G+ QK+ L +S GI +
Sbjct: 38 EGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIF 97
Query: 101 DNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTK-RKMAQAVTL 159
D T L + +++ ISY D + F Y+ + N H F+ K + A+ V L
Sbjct: 98 DEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGN-----HRFVAIKTAQAAEPVIL 152
Query: 160 TVAQAFKVAFEFWQVSK-EEKEKRDKASQE 188
+ F++ +E Q + E+K ++DK ++
Sbjct: 153 DLRDLFQLIYELKQREELEKKAQKDKQCEQ 182
>gi|50511947 cajalin 2 isoform b [Homo sapiens]
Length = 510
Score = 57.8 bits (138), Expect = 1e-08
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 3/122 (2%)
Query: 52 YLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVT---LKVSPRGIILTDNLTNQLI 108
YLG L+++ +G E + A ++ A + S ++++KV L VS +G+ D +I
Sbjct: 316 YLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNII 375
Query: 109 ENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVA 168
I IS D FAYI + + CH F +A + LT+ QAF+VA
Sbjct: 376 AEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVA 435
Query: 169 FE 170
++
Sbjct: 436 YQ 437
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 57.8 bits (138), Expect = 1e-08
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 3/122 (2%)
Query: 52 YLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVT---LKVSPRGIILTDNLTNQLI 108
YLG L+++ +G E + A ++ A + S ++++KV L VS +G+ D +I
Sbjct: 1066 YLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNII 1125
Query: 109 ENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVA 168
I IS D FAYI + + CH F +A + LT+ QAF+VA
Sbjct: 1126 AEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVA 1185
Query: 169 FE 170
++
Sbjct: 1186 YQ 1187
>gi|10047134 cajalin 2 isoform c [Homo sapiens]
Length = 414
Score = 57.8 bits (138), Expect = 1e-08
Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 3/122 (2%)
Query: 52 YLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVT---LKVSPRGIILTDNLTNQLI 108
YLG L+++ +G E + A ++ A + S ++++KV L VS +G+ D +I
Sbjct: 232 YLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNII 291
Query: 109 ENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVA 168
I IS D FAYI + + CH F +A + LT+ QAF+VA
Sbjct: 292 AEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVA 351
Query: 169 FE 170
++
Sbjct: 352 YQ 353
>gi|31377557 hypothetical protein LOC131583 [Homo sapiens]
Length = 423
Score = 57.0 bits (136), Expect = 2e-08
Identities = 49/174 (28%), Positives = 85/174 (48%), Gaps = 13/174 (7%)
Query: 44 EGMLFSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTLKVSPRGIILTDNL 103
E +++ YLG Q +G+ + A+ +I + ++A G++ K+ L VS +GI +
Sbjct: 66 EDPTYTVLYLGNATTIQARGDGCTDLAVGKIWSKSEA-GRQGTKMKLTVSAQGIRMVHAE 124
Query: 104 TNQLIENVSIY---RISYCTADKMHDKVFAYIAQSQHNQS---LECHAFLCTKRKMAQAV 157
L +Y R++YC AD KVFA++ + + L CHA L +K + AQA+
Sbjct: 125 ERALRRPGHLYLLHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQAM 184
Query: 158 TLTVAQAFKVAF-EFWQVSKEEKEKRDKASQEGGDVLGARQDCTPSLKSLVATG 210
L + Q A EF + ++RD A + +++GA L+ L+ G
Sbjct: 185 ALLLYQTSANALAEF-----KRLKRRDDARHQQQELVGAHTIPLVPLRKLLLHG 233
>gi|148491082 disabled homolog 2 [Homo sapiens]
Length = 770
Score = 54.7 bits (130), Expect = 1e-07
Identities = 38/168 (22%), Positives = 79/168 (47%), Gaps = 11/168 (6%)
Query: 44 EGMLFSLKYLGMTLVEQPKGEELSAAA---IKRIVATAKASGKKLQKVTLKVSPRGIILT 100
+G+ + K +G+ V +G+++S + +K + A ++ G+ Q++ + +S GI +
Sbjct: 46 DGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKII 105
Query: 101 DNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKR-KMAQAVTL 159
D T + + +IS+ D ++ F Y+ + H F K + A+ + +
Sbjct: 106 DEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQ-----HQFFAIKTGQQAEPLVV 160
Query: 160 TVAQAFKVAFEFWQVSKEEK--EKRDKASQEGGDVLGARQDCTPSLKS 205
+ F+V + + +E+K E+ KA + G + L D T LKS
Sbjct: 161 DLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKS 208
>gi|140161500 ankyrin repeat and sterile alpha motif domain containing
1 [Homo sapiens]
Length = 1134
Score = 52.8 bits (125), Expect = 4e-07
Identities = 35/139 (25%), Positives = 61/139 (43%), Gaps = 2/139 (1%)
Query: 33 ENWTDTRETLL-EGMLFSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTLK 91
++W E L+ E + YLG L++ +G E + A ++ + + KK+ + L
Sbjct: 926 QSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHM-KKIPTIILS 984
Query: 92 VSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKR 151
++ +G+ D +I I IS D FAYI + CH F
Sbjct: 985 ITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDV 1044
Query: 152 KMAQAVTLTVAQAFKVAFE 170
+ + LT+ QAF+VA++
Sbjct: 1045 NLTYEIILTLGQAFEVAYQ 1063
>gi|46409306 family with sequence similarity 43, member B [Homo
sapiens]
Length = 329
Score = 48.9 bits (115), Expect = 6e-06
Identities = 40/155 (25%), Positives = 67/155 (43%), Gaps = 13/155 (8%)
Query: 44 EGMLFSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTLKVSPRGIILTD-- 101
E +++ YLG + KG+ + A+ +I A G K+TL P GI +
Sbjct: 68 EDPTYTVWYLGNAVTLHAKGDGCTDDAVGKIWARCGPGGGTKMKLTL--GPHGIRMQPCE 125
Query: 102 ------NLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQS---LECHAFLCTKRK 152
+ + + RI+YCTAD H +VFA++ + Q L CHA L +
Sbjct: 126 RSAAGGSGGRRPAHAYLLPRITYCTADGRHPRVFAWVYRHQARHKAVVLRCHAVLLARAH 185
Query: 153 MAQAVTLTVAQAFKVAFEFWQVSKEEKEKRDKASQ 187
A+A+ + Q AF ++ + + + R Q
Sbjct: 186 KARALARLLRQTALAAFSDFKRLQRQSDARHVRQQ 220
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 44.3 bits (103), Expect = 1e-04
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 15/132 (11%)
Query: 44 EGMLFS-LKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTLKVS--PRGII-L 99
+ +LF+ L YLG V P+ E R +AT K+S + VTL V P G + +
Sbjct: 127 DSVLFNKLTYLGCMKVSSPRNE----VEALRAMATMKSSSQYPFPVTLYVPNVPEGSVRI 182
Query: 100 TDNLTNQLIENVSIYRISYCTADKMHD-----KVFAYIAQSQHNQSLECHAFLCTKRKMA 154
D +N I + IY++ +C + HD FA+ S ++ + H F C ++
Sbjct: 183 IDQSSNVEIASFPIYKVLFCA--RGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAV 240
Query: 155 QAVTLTVAQAFK 166
+ + AFK
Sbjct: 241 SRILYSFCTAFK 252
>gi|4885433 mitogen-activated protein kinase 8 interacting protein 1
[Homo sapiens]
Length = 711
Score = 40.8 bits (94), Expect = 0.002
Identities = 30/135 (22%), Positives = 60/135 (44%), Gaps = 11/135 (8%)
Query: 48 FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKAS--GKKLQKVTLKVSPRGIIL------ 99
F +K+LG V KG ++ AA+++I T + + L++S RG+ +
Sbjct: 567 FRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADD 626
Query: 100 -TDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLC--TKRKMAQA 156
+ N+ + IS+C ++K F +I + + CH F+ + + +A++
Sbjct: 627 SQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAES 686
Query: 157 VTLTVAQAFKVAFEF 171
V Q +K E+
Sbjct: 687 VGRAFQQFYKQFVEY 701
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 38.1 bits (87), Expect = 0.010
Identities = 36/132 (27%), Positives = 58/132 (43%), Gaps = 15/132 (11%)
Query: 44 EGMLFS-LKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTLKVS--PRGII-L 99
+ ++FS L YLG V P+ E R+++ ++ + VTL V GI+ L
Sbjct: 143 DSVVFSKLTYLGCASVNAPRSE----VEALRMMSILRSQCQISLDVTLSVPNVSEGIVRL 198
Query: 100 TDNLTNQLIENVSIYRISYCTADKMHD-----KVFAYIAQSQHNQSLECHAFLCTKRKMA 154
D TN I N IY+I +C + HD FA+ + + H F C ++
Sbjct: 199 LDPQTNTEIANYPIYKILFCV--RGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAV 256
Query: 155 QAVTLTVAQAFK 166
+ + A AF+
Sbjct: 257 SRILYSFATAFR 268
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 38.1 bits (87), Expect = 0.010
Identities = 28/85 (32%), Positives = 47/85 (55%), Gaps = 5/85 (5%)
Query: 88 VTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADK--MHDKVFAYIAQSQHNQSLECHA 145
+++ +S G+ L+ T Q+I N + IS+ + M D V AY+A+ NQ CH
Sbjct: 222 ISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYV-AYVAKDPINQRA-CHI 279
Query: 146 FLCTKRKMAQAVTLTVAQAFKVAFE 170
C + +AQ++ TV QAF++ F+
Sbjct: 280 LECCEG-LAQSIISTVGQAFELRFK 303
>gi|50083291 amyloid beta A4 precursor protein-binding, family B,
member 2 [Homo sapiens]
Length = 736
Score = 35.8 bits (81), Expect = 0.049
Identities = 25/103 (24%), Positives = 55/103 (53%), Gaps = 7/103 (6%)
Query: 48 FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKKLQKVTLKVSPRGI-ILTDNLTNQ 106
F ++YLGM V++P G ++ +AI+ ++ + ++ + V + V+ + ++++ +
Sbjct: 568 FHVQYLGMLPVDKPVGMDILNSAIENLMTS--SNKEDWLSVNMNVADATVTVISEKNEEE 625
Query: 107 LIENVSIYRISYCTADK-MHDKVFAYIAQSQHNQSLECHAFLC 148
++ + +S+ K +H FA+I + NQ ECH F C
Sbjct: 626 VLVECRVRFLSFMGVGKDVH--TFAFIMDT-GNQRFECHVFWC 665
Score = 31.6 bits (70), Expect = 0.93
Identities = 16/61 (26%), Positives = 29/61 (47%)
Query: 99 LTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVT 158
L D + ++ + I I + + + FAY+A+ + + L+CH F C A A +
Sbjct: 460 LVDPMDRSVLHSQPIVSIRVWGVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATS 519
Query: 159 L 159
L
Sbjct: 520 L 520
>gi|154816208 phosphotyrosine interaction domain containing 1
isoform 2 [Homo sapiens]
Length = 217
Score = 35.4 bits (80), Expect = 0.064
Identities = 17/66 (25%), Positives = 36/66 (54%), Gaps = 4/66 (6%)
Query: 108 IENVSIYRISYCTAD-KMHDKVFAYIAQSQHNQ---SLECHAFLCTKRKMAQAVTLTVAQ 163
++ + RI+YCTAD + +FA++ + ++ ++CHA C + A+ + + +
Sbjct: 125 MDTFQVARIAYCTADHNVSPNIFAWVYREINDDLSYQMDCHAVECESKLEAKKLAHAMME 184
Query: 164 AFKVAF 169
AF+ F
Sbjct: 185 AFRKTF 190
>gi|40255260 phosphotyrosine interaction domain containing 1 isoform
1 [Homo sapiens]
Length = 248
Score = 35.4 bits (80), Expect = 0.064
Identities = 17/66 (25%), Positives = 36/66 (54%), Gaps = 4/66 (6%)
Query: 108 IENVSIYRISYCTAD-KMHDKVFAYIAQSQHNQ---SLECHAFLCTKRKMAQAVTLTVAQ 163
++ + RI+YCTAD + +FA++ + ++ ++CHA C + A+ + + +
Sbjct: 156 MDTFQVARIAYCTADHNVSPNIFAWVYREINDDLSYQMDCHAVECESKLEAKKLAHAMME 215
Query: 164 AFKVAF 169
AF+ F
Sbjct: 216 AFRKTF 221
>gi|169211037 PREDICTED: similar to mitogen-activated protein kinase
8 interacting protein 1 [Homo sapiens]
Length = 423
Score = 34.7 bits (78), Expect = 0.11
Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 11/128 (8%)
Query: 48 FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKAS--GKKLQKVTLKVSPRGI---ILTDN 102
F +K+LG V KG+ + +AA+++I T + + L++S RG+ I D+
Sbjct: 279 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADD 338
Query: 103 LT----NQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVT 158
N+ + IS+ ++K F +I + + CH F+ +A+
Sbjct: 339 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFV--SEDSTKALA 396
Query: 159 LTVAQAFK 166
+V +AF+
Sbjct: 397 ESVGRAFQ 404
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 34.3 bits (77), Expect = 0.14
Identities = 37/111 (33%), Positives = 49/111 (44%), Gaps = 12/111 (10%)
Query: 70 AIKRIVATAKASGKKLQKVTLKVSPRGIILTD--------NLTNQ-LIENVSIYRISYCT 120
AIK+ K L K L+ S I LT NL NQ +I N + IS+ +
Sbjct: 235 AIKKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFAS 294
Query: 121 A-DKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVAFE 170
D AY+A+ NQ CH C MAQ V T+ QAF++ F+
Sbjct: 295 GGDPDTTDYVAYVAKDPVNQRA-CHILEC-HNGMAQDVISTIGQAFELRFK 343
>gi|239740950 PREDICTED: similar to mitogen-activated protein kinase
8 interacting protein 1 [Homo sapiens]
Length = 442
Score = 34.3 bits (77), Expect = 0.14
Identities = 28/128 (21%), Positives = 57/128 (44%), Gaps = 11/128 (8%)
Query: 48 FSLKYLGMTLVEQPKGEELSAAAIKRIVATAKAS--GKKLQKVTLKVSPRGIIL------ 99
F +K+LG V KG+ + +AA+++I T + + L++S RG+ +
Sbjct: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADD 357
Query: 100 -TDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLECHAFLCTKRKMAQAVT 158
+ N+ + IS+ ++K F +I + + CH F+ +A+
Sbjct: 358 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFV--SEDSTKALA 415
Query: 159 LTVAQAFK 166
+V +AF+
Sbjct: 416 ESVGRAFQ 423
>gi|11342678 amyloid beta (A4) precursor protein-binding, family A,
member 3 [Homo sapiens]
Length = 575
Score = 32.7 bits (73), Expect = 0.42
Identities = 37/145 (25%), Positives = 63/145 (43%), Gaps = 19/145 (13%)
Query: 40 ETLLEGMLFSLKYLGMTLVEQPKGEELSA--AAIKRIVATAKASGKKLQKVT---LKVSP 94
E LL+G++F +YLG T + + S A + + KA + Q +T L VS
Sbjct: 213 EDLLDGVIFGARYLGSTQLVSERNPPTSTRMAQAREAMDRVKAPDGETQPMTEVDLFVST 272
Query: 95 RGIILTDNLTNQLIENVSIYRISYCTAD-------KMHDKVFAYIAQSQHNQSLE---CH 144
+ I + + + + + +++ ISY TAD ++ A H + L CH
Sbjct: 273 KRIKVLTADSQEAMMDHALHTISY-TADIGCVLVLMARRRLARRPAPQDHGRRLYKMLCH 331
Query: 145 AFLCTKRKMAQAVTLTVAQAFKVAF 169
F + AQ + + QAF A+
Sbjct: 332 VFYA---EDAQLIAQAIGQAFAAAY 353
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 32.3 bits (72), Expect = 0.54
Identities = 17/68 (25%), Positives = 29/68 (42%), Gaps = 3/68 (4%)
Query: 104 TNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQS---LECHAFLCTKRKMAQAVTLT 160
T ++ + IS+C+ H F +I + C+ F CT + + +T
Sbjct: 307 TKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALVDEIMMT 366
Query: 161 VAQAFKVA 168
+ QAF VA
Sbjct: 367 LKQAFTVA 374
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 31.2 bits (69), Expect = 1.2
Identities = 18/68 (26%), Positives = 27/68 (39%), Gaps = 3/68 (4%)
Query: 104 TNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLE---CHAFLCTKRKMAQAVTLT 160
T ++ + IS C+ H F +I + L C+ F C + V LT
Sbjct: 373 TKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLT 432
Query: 161 VAQAFKVA 168
+ QAF A
Sbjct: 433 LKQAFSTA 440
>gi|139394599 hypermethylated in cancer 2 [Homo sapiens]
Length = 615
Score = 30.8 bits (68), Expect = 1.6
Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 16/107 (14%)
Query: 190 GDVLGARQDCTPSLKSLVATGNLLDLEETAKA----------PLSTVSANTTNMDEVPRP 239
G +L + Q P+ +L+ + L L E A P + A +T M PR
Sbjct: 103 GKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPPRS 162
Query: 240 QALSGSSVVWELDDGLDE------AFSRLAQSRTNPQVLDTGLTAQD 280
Q LS +SV+ GL + A L Q++ + L G + QD
Sbjct: 163 QRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQD 209
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,890,581
Number of Sequences: 37866
Number of extensions: 443418
Number of successful extensions: 1096
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 1049
Number of HSP's gapped (non-prelim): 63
length of query: 308
length of database: 18,247,518
effective HSP length: 102
effective length of query: 206
effective length of database: 14,385,186
effective search space: 2963348316
effective search space used: 2963348316
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.