Search of human proteins with 4826740

Search of human proteins with 4826740

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
         (478 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4826740 growth differentiation factor 10 precursor [Homo sapi...   984   0.0  
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa...   342   4e-94
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi...   113   3e-25
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa...   112   6e-25
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa...   112   6e-25
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa...   112   6e-25
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]      112   7e-25
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa...   110   2e-24
gi|48475062 growth differentiation factor 6 precursor [Homo sapi...   110   4e-24
gi|145611428 bone morphogenetic protein 8A [Homo sapiens]             109   5e-24
gi|4503969 growth differentiation factor 5 preproprotein [Homo s...   109   6e-24
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap...   108   8e-24
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi...   108   1e-23
gi|61835232 growth differentiation factor 7 preproprotein [Homo ...   107   2e-23
gi|10190670 growth differentiation factor 3 precursor [Homo sapi...    99   8e-21
gi|110349792 growth differentiation factor 1 [Homo sapiens]            92   1e-18
gi|7705308 growth differentiation factor 2 [Homo sapiens]              92   1e-18
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap...    89   1e-17
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]       84   3e-16
gi|222352098 nodal precursor [Homo sapiens]                            84   4e-16
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]      78   2e-14
gi|4504699 inhibin beta A precursor [Homo sapiens]                     77   3e-14
gi|13899338 activin beta E [Homo sapiens]                              75   1e-13
gi|5031613 growth differentiation factor 11 precursor [Homo sapi...    73   5e-13
gi|4885259 myostatin [Homo sapiens]                                    71   2e-12
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]           70   3e-12
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]    63   5e-10
gi|153792495 growth differentiation factor 15 [Homo sapiens]           58   2e-08
gi|239757187 PREDICTED: similar to growth differentiation factor...    58   2e-08
gi|4504697 inhibin alpha subunit precursor [Homo sapiens]              55   1e-07

>gi|4826740 growth differentiation factor 10 precursor [Homo
           sapiens]
          Length = 478

 Score =  984 bits (2544), Expect = 0.0
 Identities = 478/478 (100%), Positives = 478/478 (100%)

Query: 1   MAHVPARTSPGPGPQLLLLLLPLFLLLLRDVAGSHRAPAWSALPAAADGLQGDRDLQRHP 60
           MAHVPARTSPGPGPQLLLLLLPLFLLLLRDVAGSHRAPAWSALPAAADGLQGDRDLQRHP
Sbjct: 1   MAHVPARTSPGPGPQLLLLLLPLFLLLLRDVAGSHRAPAWSALPAAADGLQGDRDLQRHP 60

Query: 61  GDAAATLGPSAQDMVAVHMHRLYEKYSRQGARPGGGNTVRSFRARLEVVDQKAVYFFNLT 120
           GDAAATLGPSAQDMVAVHMHRLYEKYSRQGARPGGGNTVRSFRARLEVVDQKAVYFFNLT
Sbjct: 61  GDAAATLGPSAQDMVAVHMHRLYEKYSRQGARPGGGNTVRSFRARLEVVDQKAVYFFNLT 120

Query: 121 SMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGRPLPLGPPTRQHLLFRSLSQN 180
           SMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGRPLPLGPPTRQHLLFRSLSQN
Sbjct: 121 SMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGRPLPLGPPTRQHLLFRSLSQN 180

Query: 181 TATQGLLRGAMALAPPPRGLWQAKDISPIVKAARRDGELLLSAQLDSEERDPGVPRPSPY 240
           TATQGLLRGAMALAPPPRGLWQAKDISPIVKAARRDGELLLSAQLDSEERDPGVPRPSPY
Sbjct: 181 TATQGLLRGAMALAPPPRGLWQAKDISPIVKAARRDGELLLSAQLDSEERDPGVPRPSPY 240

Query: 241 APYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQD 300
           APYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQD
Sbjct: 241 APYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQD 300

Query: 301 NELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEK 360
           NELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEK
Sbjct: 301 NELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEK 360

Query: 361 TMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPS 420
           TMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPS
Sbjct: 361 TMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPS 420

Query: 421 NHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
           NHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR
Sbjct: 421 NHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478


>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
           sapiens]
          Length = 472

 Score =  342 bits (877), Expect = 4e-94
 Identities = 215/461 (46%), Positives = 279/461 (60%), Gaps = 67/461 (14%)

Query: 60  PGDAAATLGPSA----QDMVAVHMHRLYEKYSR-QGARPGG----------------GNT 98
           PGD  A  GP +    QD V+ HM RLY++YS  Q AR  G                GNT
Sbjct: 37  PGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNT 96

Query: 99  VRSFRARL-EVVDQKAVYFFNLTSMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNA 157
           VRSFRA   E +++K +Y FNLTS+  SE IL+AT +F              C     N 
Sbjct: 97  VRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYF--------------CIGELGNI 142

Query: 158 S-GRPLPLG---PPTRQHL---LFRSLSQNTATQGLLRGAMA--LAPPPRGL--WQAKDI 206
           S   P+  G      R+H+   L     + +  Q  L G ++  +A   R +  W +KDI
Sbjct: 143 SLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDI 202

Query: 207 SPIVKAARRDGELLLSAQLDSEERD-PGVPRPSPYAPYILVYANDLAISEPNSVAVTLQR 265
           + +++ A+ + E L+   + S+ R  P    P P  PYILVYAND AISEP SV  +LQ 
Sbjct: 203 TQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFP-EPYILVYANDAAISEPESVVSSLQG 261

Query: 266 YDPFPAG-----DPEPRAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHK 320
           +  FP G     D   RAA   S + R +R+     PLQ+NELPG + +        + K
Sbjct: 262 HRNFPTGTVPKWDSHIRAAL--SIERRKKRSTGVLLPLQNNELPGAEYQ--------YKK 311

Query: 321 HQLWPS--PFRALKPRPGRKDRRKKGQEVFM-AASQVLDFDEKTMQKARRKQWDEPRVCS 377
            ++W    P++ L+ +   K + KK Q       SQ L FDE+T++KARRKQW EPR C+
Sbjct: 312 DEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCA 371

Query: 378 RRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPG 437
           RRYLKVDFADIGW+EWIISPKSFDAYYC+GAC+FPMPK ++PSNHATIQSIVRAVG++PG
Sbjct: 372 RRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPG 431

Query: 438 IPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
           IPEPCCVP+KM+SL +LF DEN+NVVLKVYPNM+V++CACR
Sbjct: 432 IPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472


>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
           sapiens]
          Length = 396

 Score =  113 bits (283), Expect = 3e-25
 Identities = 47/103 (45%), Positives = 71/103 (68%), Gaps = 2/103 (1%)

Query: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
           C R  L VDF+D+GWN+WI++P  + A+YC G C FP+   +  +NHA +Q++V +V   
Sbjct: 296 CKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-- 353

Query: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
             IP+ CCVP +++++ +L+LDEN  VVLK Y +M V+ C CR
Sbjct: 354 SKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 396



 Score = 30.4 bits (67), Expect = 3.7
 Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 17/87 (19%)

Query: 69  PSAQDMVAVHMHRLYEKYSRQGARPGG----------GNTVRSFRAR--LEVVDQKAV-- 114
           PS   +V  +M  LY ++S Q   P             NTVRSF     LE + + +   
Sbjct: 69  PSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKT 128

Query: 115 ---YFFNLTSMQDSEMILTATFHFYSE 138
              +FFNL+S+   E I +A    + E
Sbjct: 129 TRRFFFNLSSIPTEEFITSAELQVFRE 155


>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  112 bits (281), Expect = 6e-25
 Identities = 50/116 (43%), Positives = 76/116 (65%), Gaps = 6/116 (5%)

Query: 363 QKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNH 422
           Q+AR+K     + C R  L VDF+D+GWN+WI++P  + A+YC G C FP+   +  +NH
Sbjct: 299 QRARKKN----KNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNH 354

Query: 423 ATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
           A +Q++V +V     IP+ CCVP +++++ +L+LDE   VVLK Y  M V+ C CR
Sbjct: 355 AIVQTLVNSVN--SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  112 bits (281), Expect = 6e-25
 Identities = 50/116 (43%), Positives = 76/116 (65%), Gaps = 6/116 (5%)

Query: 363 QKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNH 422
           Q+AR+K     + C R  L VDF+D+GWN+WI++P  + A+YC G C FP+   +  +NH
Sbjct: 299 QRARKKN----KNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNH 354

Query: 423 ATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
           A +Q++V +V     IP+ CCVP +++++ +L+LDE   VVLK Y  M V+ C CR
Sbjct: 355 AIVQTLVNSVN--SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
           sapiens]
          Length = 408

 Score =  112 bits (281), Expect = 6e-25
 Identities = 50/116 (43%), Positives = 76/116 (65%), Gaps = 6/116 (5%)

Query: 363 QKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNH 422
           Q+AR+K     + C R  L VDF+D+GWN+WI++P  + A+YC G C FP+   +  +NH
Sbjct: 299 QRARKKN----KNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNH 354

Query: 423 ATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
           A +Q++V +V     IP+ CCVP +++++ +L+LDE   VVLK Y  M V+ C CR
Sbjct: 355 AIVQTLVNSVN--SSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR 408


>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
          Length = 431

 Score =  112 bits (280), Expect = 7e-25
 Identities = 51/146 (34%), Positives = 79/146 (54%), Gaps = 12/146 (8%)

Query: 332 KPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWN 391
           K R   + +  K QE    A+            A     D+ + C +  L V F D+GW 
Sbjct: 297 KQRSQNRSKTPKNQEALRMANV-----------AENSSSDQRQACKKHELYVSFRDLGWQ 345

Query: 392 EWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSL 451
           +WII+P+ + AYYC G C FP+   +  +NHA +Q++V  +     +P+PCC P ++N++
Sbjct: 346 DWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFIN-PETVPKPCCAPTQLNAI 404

Query: 452 GVLFLDENRNVVLKVYPNMSVDTCAC 477
            VL+ D++ NV+LK Y NM V  C C
Sbjct: 405 SVLYFDDSSNVILKKYRNMVVRACGC 430


>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
           sapiens]
          Length = 402

 Score =  110 bits (276), Expect = 2e-24
 Identities = 56/154 (36%), Positives = 85/154 (55%), Gaps = 9/154 (5%)

Query: 325 PSPFRALKP-RPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKV 383
           PSP R  +  RP R+ + KK  E+  A      FD+      R+       VC R  L V
Sbjct: 256 PSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQ-------VCRRHELYV 308

Query: 384 DFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCC 443
            F D+GW +W+I+P+ + AYYC G C FP+   +  +NHA +QS+V  + +   +P+ CC
Sbjct: 309 SFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLM-MPDAVPKACC 367

Query: 444 VPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
            P K+++  VL+ D + NV+L+ + NM V  C C
Sbjct: 368 APTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|48475062 growth differentiation factor 6 precursor [Homo
           sapiens]
          Length = 455

 Score =  110 bits (274), Expect = 4e-24
 Identities = 58/161 (36%), Positives = 93/161 (57%), Gaps = 24/161 (14%)

Query: 324 WPSPF-----RALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSR 378
           WP P      R   P PGR+ RR         AS+     ++  +K+R +       CS+
Sbjct: 313 WPPPSGAPDARPWLPSPGRRRRRTA------FASR---HGKRHGKKSRLR-------CSK 356

Query: 379 RYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPG- 437
           + L V+F ++GW++WII+P  ++AY+C G C+FP+   + P+NHA IQ+++ ++   PG 
Sbjct: 357 KPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMD--PGS 414

Query: 438 IPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
            P  CCVP K+  + +L++D   NVV K Y +M V++C CR
Sbjct: 415 TPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 455


>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
          Length = 402

 Score =  109 bits (273), Expect = 5e-24
 Identities = 56/154 (36%), Positives = 84/154 (54%), Gaps = 9/154 (5%)

Query: 325 PSPFRALKP-RPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKV 383
           PSP R  +  RP R+ + KK  E+  A      FD+      R+       VC R  L V
Sbjct: 256 PSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQ-------VCRRHELYV 308

Query: 384 DFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCC 443
            F D+GW +W+I+P+ + AYYC G C FP+   +  +NHA +QS+V  +     +P+ CC
Sbjct: 309 SFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMK-PNAVPKACC 367

Query: 444 VPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
            P K+++  VL+ D + NV+L+ + NM V  C C
Sbjct: 368 APTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401


>gi|4503969 growth differentiation factor 5 preproprotein [Homo
           sapiens]
          Length = 501

 Score =  109 bits (272), Expect = 6e-24
 Identities = 44/103 (42%), Positives = 71/103 (68%), Gaps = 1/103 (0%)

Query: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
           CSR+ L V+F D+GW++WII+P  ++A++C G CEFP+   + P+NHA IQ+++ ++   
Sbjct: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD-P 458

Query: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
              P  CCVP +++ + +LF+D   NVV K Y +M V++C CR
Sbjct: 459 ESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501


>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
           sapiens]
          Length = 454

 Score =  108 bits (271), Expect = 8e-24
 Identities = 43/107 (40%), Positives = 70/107 (65%), Gaps = 1/107 (0%)

Query: 371 DEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVR 430
           ++ + C +  L V F D+GW +WII+P+ + A+YC G C FP+   +  +NHA +Q++V 
Sbjct: 348 EQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVH 407

Query: 431 AVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
            +     +P+PCC P K+N++ VL+ D++ NV+LK Y NM V +C C
Sbjct: 408 LM-FPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453


>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
           sapiens]
          Length = 513

 Score =  108 bits (269), Expect = 1e-23
 Identities = 52/144 (36%), Positives = 81/144 (56%), Gaps = 12/144 (8%)

Query: 334 RPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEW 393
           R   ++R  + Q+V   +S   D++   ++ A          C +  L V F D+GW +W
Sbjct: 381 RQQSRNRSTQSQDVARVSS-ASDYNSSELKTA----------CRKHELYVSFQDLGWQDW 429

Query: 394 IISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGV 453
           II+PK + A YC G C FP+   +  +NHA +Q++V  +     +P+PCC P K+N++ V
Sbjct: 430 IIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN-PEYVPKPCCAPTKLNAISV 488

Query: 454 LFLDENRNVVLKVYPNMSVDTCAC 477
           L+ D+N NV+LK Y NM V  C C
Sbjct: 489 LYFDDNSNVILKKYRNMVVRACGC 512


>gi|61835232 growth differentiation factor 7 preproprotein [Homo
           sapiens]
          Length = 450

 Score =  107 bits (268), Expect = 2e-23
 Identities = 43/103 (41%), Positives = 70/103 (67%), Gaps = 1/103 (0%)

Query: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
           CSR+ L VDF ++GW++WII+P  ++AY+C G C+FP+   + P+NHA IQ+++ ++   
Sbjct: 349 CSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMA-P 407

Query: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
              P  CCVP +++ + +L++D   NVV K Y +M V+ C CR
Sbjct: 408 DAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 450


>gi|10190670 growth differentiation factor 3 precursor [Homo
           sapiens]
          Length = 364

 Score = 99.0 bits (245), Expect = 8e-21
 Identities = 43/103 (41%), Positives = 67/103 (65%), Gaps = 2/103 (1%)

Query: 375 VCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGI 434
           +C R  L ++F D+GW++WII+PK F A YC G C F +   +  SN+A +Q+++ AV  
Sbjct: 263 LCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVD- 321

Query: 435 IPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
            P IP+  C+P K++ + +L+ D N NV+L+ Y +M VD C C
Sbjct: 322 -PEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 68/223 (30%), Positives = 102/223 (45%), Gaps = 29/223 (13%)

Query: 278 AAPNNSADPRVRRAAQATG----PLQDNELPGLDERPPRAH--AQHFHKHQLWPSPFR-- 329
           AAP    +  V +A Q  G    P+   +L      P RA      + ++  WP   R  
Sbjct: 157 AAPEGGWELSVAQAGQGAGADPGPVLLRQLVPALGPPVRAELLGAAWARNASWPRSLRLA 216

Query: 330 -ALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRV--------CSRRY 380
            AL+PR      R     +  A+  ++  D +      R + D   V        C  R 
Sbjct: 217 LALRPRAPAACAR-----LAEASLLLVTLDPRLCHPLARPRRDAEPVLGGGPGGACRARR 271

Query: 381 LKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPS----NHATIQSIVRAVGIIP 436
           L V F ++GW+ W+I+P+ F A YC G C  P+           NHA +++++ A    P
Sbjct: 272 LYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHAAA--P 329

Query: 437 GIPE-PCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
           G  + PCCVP +++ + VLF D + NVVL+ Y +M VD C CR
Sbjct: 330 GAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372


>gi|7705308 growth differentiation factor 2 [Homo sapiens]
          Length = 429

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 43/104 (41%), Positives = 63/104 (60%), Gaps = 2/104 (1%)

Query: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
           C +  L+V+F DIGW+ WII+PK ++AY C G C FP+   V P+ HA +Q++V  +   
Sbjct: 327 CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVH-LKFP 385

Query: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKV-YPNMSVDTCACR 478
             + + CCVP K++ + VL+ D+     LK  Y  MSV  C CR
Sbjct: 386 TKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429


>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
           sapiens]
          Length = 424

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 5/135 (3%)

Query: 344 GQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAY 403
           G+E  +     + +D      AR ++  +   C R  L +DF +IGW+ WII+P  ++AY
Sbjct: 295 GEEALLQMRSNIIYDST----ARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAY 350

Query: 404 YCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVV 463
            C G C +P+ + + P+ HA IQ++V          + CCVP K+  + +L+LD+     
Sbjct: 351 ECRGVCNYPLAEHLTPTKHAIIQALVHLKN-SQKASKACCVPTKLEPISILYLDKGVVTY 409

Query: 464 LKVYPNMSVDTCACR 478
              Y  M+V  C CR
Sbjct: 410 KFKYEGMAVSECGCR 424


>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
          Length = 407

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 35/105 (33%), Positives = 60/105 (57%), Gaps = 2/105 (1%)

Query: 375 VCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSN--HATIQSIVRAV 432
           +C R+   +DF  IGWN+WII+P  +   YC G+C   +  +   ++  H  + +  R  
Sbjct: 302 LCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMR 361

Query: 433 GIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
           G+ PG    CC+P K++++ +L+ D+  N+V +  PNM V+ C C
Sbjct: 362 GLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406


>gi|222352098 nodal precursor [Homo sapiens]
          Length = 347

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 41/107 (38%), Positives = 61/107 (57%), Gaps = 2/107 (1%)

Query: 371 DEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVR 430
           D  ++C +   +VDF  IGW  WII PK ++AY C G C  P+ +   P+NHA IQS+++
Sbjct: 242 DRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTNHAYIQSLLK 301

Query: 431 AVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
                  +P  CC P K   L +L++D  R V+L  + +M V+ C C
Sbjct: 302 RYQ-PHRVPSTCCAPVKTKPLSMLYVDNGR-VLLDHHKDMIVEECGC 346


>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
          Length = 392

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 39/143 (27%), Positives = 66/143 (46%), Gaps = 8/143 (5%)

Query: 343 KGQEVFMAASQVL-------DFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWII 395
           +G E FM    +L           +    + +    E   CS    ++ F  +GW+ WII
Sbjct: 251 RGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWII 310

Query: 396 SPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLF 455
           +P  +   YC G C   +   +   NHA IQ+++  + +   +P P CVP K   + VL 
Sbjct: 311 APPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQL-VDQSVPRPSCVPYKYVPISVLM 369

Query: 456 LDENRNVVLKVYPNMSVDTCACR 478
           ++ N +++ K Y  M  ++C CR
Sbjct: 370 IEANGSILYKEYEGMIAESCTCR 392


>gi|4504699 inhibin beta A precursor [Homo sapiens]
          Length = 426

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 42/146 (28%), Positives = 71/146 (48%), Gaps = 4/146 (2%)

Query: 336 GRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWD-EPRVCSRRYLKVDFADIGWNEWI 394
           G  + +++    F+        D    ++ R  + D +  +C ++   V F DIGWN+WI
Sbjct: 280 GADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWI 339

Query: 395 ISPKSFDAYYCAGACEFPMPKIVRP--SNHATIQSIVRAVGIIP-GIPEPCCVPDKMNSL 451
           I+P  + A YC G C   +        S H+T+ +  R  G  P    + CCVP K+  +
Sbjct: 340 IAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPM 399

Query: 452 GVLFLDENRNVVLKVYPNMSVDTCAC 477
            +L+ D+ +N++ K   NM V+ C C
Sbjct: 400 SMLYYDDGQNIIKKDIQNMIVEECGC 425


>gi|13899338 activin beta E [Homo sapiens]
          Length = 350

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 41/116 (35%), Positives = 59/116 (50%), Gaps = 5/116 (4%)

Query: 366 RRKQWDEPR--VCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGAC--EFPMPKIVRPSN 421
           RR    EP   +C RR   VDF ++GW +WI+ P+ +   YC+G C         +  S 
Sbjct: 235 RRTPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASF 294

Query: 422 HATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
           H+ + S+++A    P     CCVP     L +L+LD N NVV    P+M V+ C C
Sbjct: 295 HSAVFSLLKANNPWPA-STSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349


>gi|5031613 growth differentiation factor 11 precursor [Homo
           sapiens]
          Length = 407

 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 37/102 (36%), Positives = 53/102 (51%), Gaps = 8/102 (7%)

Query: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
           C R  L VDF   GW +WII+PK + A YC+G CE+   +   P  H   Q+  R     
Sbjct: 313 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKY-PHTHLVQQANPR----- 365

Query: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
            G   PCC P KM+ + +L+ ++ + ++    P M VD C C
Sbjct: 366 -GSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406


>gi|4885259 myostatin [Homo sapiens]
          Length = 375

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 38/102 (37%), Positives = 51/102 (50%), Gaps = 8/102 (7%)

Query: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
           C R  L VDF   GW +WII+PK + A YC+G CEF   +   P  H   Q+  R     
Sbjct: 281 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKY-PHTHLVHQANPR----- 333

Query: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
            G   PCC P KM+ + +L+ +    ++    P M VD C C
Sbjct: 334 -GSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374


>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
          Length = 352

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 35/109 (32%), Positives = 57/109 (52%), Gaps = 7/109 (6%)

Query: 374 RVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKI--VRPSNHATIQSIVR- 430
           R+C R+   VDF +IGW++WII P+ +   +C G C   +  +  +  S H  + ++++ 
Sbjct: 245 RMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKA 304

Query: 431 --AVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
             A G   G    CCVP     L +L+ D + N+V    P+M V+ C C
Sbjct: 305 NTAAGTTGG--GSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351


>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
          Length = 454

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 28/103 (27%), Positives = 50/103 (48%), Gaps = 1/103 (0%)

Query: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
           C     ++ F+ + W+ WI++P  ++  YC G C   +        H  +Q+I+    + 
Sbjct: 353 CELHDFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK-LD 411

Query: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
             +P P CVP K + L VL ++ + ++  K Y +M    C CR
Sbjct: 412 SSVPRPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454


>gi|153792495 growth differentiation factor 15 [Homo sapiens]
          Length = 308

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 7/105 (6%)

Query: 374 RVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSN-HATIQSIVRAV 432
           R C    ++    D+GW +W++SP+      C GAC    P   R +N HA I++ +  +
Sbjct: 209 RCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGAC----PSQFRAANMHAQIKTSLHRL 264

Query: 433 GIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
                +P PCCVP   N + VL    +  V L+ Y ++    C C
Sbjct: 265 K-PDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 307


>gi|239757187 PREDICTED: similar to growth differentiation factor 15
           [Homo sapiens]
          Length = 270

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 7/105 (6%)

Query: 374 RVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSN-HATIQSIVRAV 432
           R C    ++    D+GW +W++SP+      C GAC    P   R +N HA I++ +  +
Sbjct: 171 RCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGAC----PSQFRAANMHAQIKTSLHRL 226

Query: 433 GIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCAC 477
                +P PCCVP   N + VL    +  V L+ Y ++    C C
Sbjct: 227 K-PDTVPAPCCVPASYNPM-VLIQKTDTGVSLQTYDDLLAKDCHC 269


>gi|4504697 inhibin alpha subunit precursor [Homo sapiens]
          Length = 366

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 31/105 (29%), Positives = 47/105 (44%), Gaps = 4/105 (3%)

Query: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
           C R  L + F ++GW  WI+ P SF  +YC G C   +P  +         +  +   ++
Sbjct: 262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLL 321

Query: 436 PGIPEPCC--VPDKMNSLGV-LFLDENRNVVLKVYPNMSVDTCAC 477
           PG  +PCC  +P  M  L V    D   +   +  PN+    CAC
Sbjct: 322 PG-AQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQHCAC 365


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,572,374
Number of Sequences: 37866
Number of extensions: 1238125
Number of successful extensions: 4318
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 4175
Number of HSP's gapped (non-prelim): 165
length of query: 478
length of database: 18,247,518
effective HSP length: 106
effective length of query: 372
effective length of database: 14,233,722
effective search space: 5294944584
effective search space used: 5294944584
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.