Search of human proteins with 47834348

Search of human proteins with 47834348

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47834348 minor histocompatibility antigen HA-1 [Homo
sapiens]
         (1136 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]     2254   0.0  
gi|134304853 PTPL1-associated RhoGAP 1 [Homo sapiens]                 590   e-168
gi|91208437 GEM interacting protein [Homo sapiens]                    478   e-134
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     127   6e-29
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    127   6e-29
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            125   2e-28
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          125   2e-28
gi|229094128 active breakpoint cluster region-related  protein i...   117   8e-26
gi|38679957 active breakpoint cluster region-related  protein is...   117   8e-26
gi|38679954 active breakpoint cluster region-related  protein is...   117   8e-26
gi|194272142 myosin IXB isoform 2 [Homo sapiens]                      111   3e-24
gi|33356170 myosin IXB isoform 1 [Homo sapiens]                       111   3e-24
gi|4505507 oligophrenin 1 [Homo sapiens]                              110   6e-24
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          108   2e-23
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]        108   4e-23
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]        108   4e-23
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]           107   6e-23
gi|208022687 GTPase regulator associated with the focal adhesion...   104   4e-22
gi|7662208 GTPase regulator associated with the focal adhesion k...   104   4e-22
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]           104   4e-22
gi|156119615 myosin IXA [Homo sapiens]                                104   5e-22
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap...   103   7e-22
gi|188497642 ARHGAP15 [Homo sapiens]                                  100   8e-21
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           99   2e-20
gi|54860079 nadrin isoform 1 [Homo sapiens]                            99   3e-20
gi|54860105 nadrin isoform 2 [Homo sapiens]                            99   3e-20
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]            98   4e-20
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s...    97   9e-20
gi|149274655 synapse defective 1, Rho GTPase, homolog 2 [Homo sa...    97   1e-19
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]            96   2e-19

>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
          Length = 1136

 Score = 2254 bits (5840), Expect = 0.0
 Identities = 1136/1136 (100%), Positives = 1136/1136 (100%)

Query: 1    MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPGPSLEPPAGSSGVKATG 60
            MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPGPSLEPPAGSSGVKATG
Sbjct: 1    MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPGPSLEPPAGSSGVKATG 60

Query: 61   TLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELPTEGAGPDVVEDISHLL 120
            TLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELPTEGAGPDVVEDISHLL
Sbjct: 61   TLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELPTEGAGPDVVEDISHLL 120

Query: 121  ADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVETLTAA 180
            ADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVETLTAA
Sbjct: 121  ADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVETLTAA 180

Query: 181  GTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSS 240
            GTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSS
Sbjct: 181  GTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSS 240

Query: 241  QSMESLYGPGSEGTPPSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLI 300
            QSMESLYGPGSEGTPPSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLI
Sbjct: 241  QSMESLYGPGSEGTPPSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLI 300

Query: 301  SYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGT 360
            SYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGT
Sbjct: 301  SYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGT 360

Query: 361  LQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKAR 420
            LQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKAR
Sbjct: 361  LQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKAR 420

Query: 421  FLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQEL 480
            FLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQEL
Sbjct: 421  FLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQEL 480

Query: 481  EDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQY 540
            EDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQY
Sbjct: 481  EDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQY 540

Query: 541  ASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCT 600
            ASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCT
Sbjct: 541  ASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCT 600

Query: 601  EGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVD 660
            EGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVD
Sbjct: 601  EGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVD 660

Query: 661  PDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSY 720
            PDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSY
Sbjct: 661  PDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSY 720

Query: 721  VYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKK 780
            VYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKK
Sbjct: 721  VYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKK 780

Query: 781  CVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQL 840
            CVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQL
Sbjct: 781  CVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQL 840

Query: 841  PEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPP 900
            PEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPP
Sbjct: 841  PEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPP 900

Query: 901  ENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQA 960
            ENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQA
Sbjct: 901  ENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQA 960

Query: 961  RVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGC 1020
            RVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGC
Sbjct: 961  RVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGC 1020

Query: 1021 RESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEA 1080
            RESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEA
Sbjct: 1021 RESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEA 1080

Query: 1081 TAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFV 1136
            TAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFV
Sbjct: 1081 TAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFV 1136


>gi|134304853 PTPL1-associated RhoGAP 1 [Homo sapiens]
          Length = 1261

 Score =  590 bits (1521), Expect = e-168
 Identities = 370/1028 (35%), Positives = 564/1028 (54%), Gaps = 80/1028 (7%)

Query: 116  ISHLLADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVE 175
            I  L+ D+ +F+  L  LKE +  D   E      H  L E LRV+  I++K+  LN+V+
Sbjct: 45   IKELVNDIRKFSHMLLYLKEAIFSDCFKEV----IHIRLEELLRVLKSIMNKHQNLNSVD 100

Query: 176  TLTAAGTLIAKVKAFHY-----ESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSST 230
               AA  L AKVKA ++     E+ NDL ++ F  ++ET+A  F + ++ FLMG+V + +
Sbjct: 101  LQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFS-SIETLAFTFGNILTNFLMGDVGNDS 159

Query: 231  LLAVPPGDSSQSMESLYGPGSEGTPPSLEDCDA----GCLPAEEVDVLLQRCEGGVDAAL 286
            LL +P    ++S E++          S+E  D+    G     E+D +L +    ++ AL
Sbjct: 160  LLRLPVSRETKSFENV----------SVESVDSSSEKGNFSPLELDNVLLKNTDSIELAL 209

Query: 287  LYAKNMAKYMKDLISYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQ 346
             YAK  +KY K+++S++EK+  LE+E  + + K+A   R ++  +  MPL S+++ AL  
Sbjct: 210  SYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLN 269

Query: 347  DLEFGHSMVQAVGTLQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAK 406
            D+E  H + Q +  LQ   F+QPL  R+ E EK+RKEIKE W + Q K+ EAE+ L+KAK
Sbjct: 270  DIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAK 329

Query: 407  QGYVQRCEDHDKARFLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATY 466
               +QR ++++KA+  + +AEEE   S+ G      K L+K+RRLEEEA  K EEA   Y
Sbjct: 330  LLCMQRQDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELY 389

Query: 467  RTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQM 526
            + CV + + ++ +LE+TK   L Q++ ++ Q D T+K+ T++ + M H+Q A L    Q 
Sbjct: 390  KVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQS 449

Query: 527  LCESSKLYDPGQQYASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVAR 586
            LC+S+KLYDPGQ+Y+  V+     +E  V  +   H++++  S    A     ++ DV R
Sbjct: 450  LCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPAN----SLEDVVR 505

Query: 587  PEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSI-SDSDS--------GLD-PGPG 636
               + +  EE  C+            G    +SW   + SDS+S         LD     
Sbjct: 506  LPDSSNKIEEDRCSNSADI------TGPSFIRSWTFGMFSDSESTGGSSESRSLDSESIS 559

Query: 637  AGDF-KKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEG 695
             GDF +K  RT SSGTMSS ++L + +  + +     +               G F+   
Sbjct: 560  PGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNS--------------LGTFKKTL 605

Query: 696  LSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGR 755
            +SKAA TH+ RKLR+P KCR+C   V FQG ECEEC L CH+KCLE L I CGH+KL G+
Sbjct: 606  MSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGK 665

Query: 756  LQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENG 815
            + LFG +F+  A+  PDG+PFI+K C  EIE RAL  +GIYRV G K + EKLCQA ENG
Sbjct: 666  IHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENG 725

Query: 816  KELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQ 875
              LV++S+ S HDI +VLKLYLRQLPEP I FRLY E + LAK+      E +      +
Sbjct: 726  MHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLE 785

Query: 876  DGS-ESEAVAV-ALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIV 933
            D    +  + +  +  + ++LLR LP  N  SL +L+ HL+R+V+  ++NKM   NLG++
Sbjct: 786  DKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVI 845

Query: 934  FGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRA 993
            FGP+L+RPRPT A +++SSL +Y +QAR++E LI +   +F            + S Q  
Sbjct: 846  FGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIF------------DGSLQPQ 893

Query: 994  EVVVQVPYLEAGEAVVYPLQEAAADGCRESRVVSNDSDSDLEEASELLSSSEASALGH-L 1052
            +V+  +  ++ G      L     D  R  + +   S  D+       S SE+       
Sbjct: 894  DVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIH-----TSESESKIFERAT 948

Query: 1053 SFLEQQQSEASLEVASGSHSGSEE-QLEATAREDGDGDEDGPAQQLSGFNTNQSNNVLQA 1111
            SF E ++ + +L       S   +  L+  A       EDG   +     +++S N ++ 
Sbjct: 949  SFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVER 1008

Query: 1112 PLPPMRLR 1119
              P  ++R
Sbjct: 1009 HTPRTKIR 1016


>gi|91208437 GEM interacting protein [Homo sapiens]
          Length = 970

 Score =  478 bits (1229), Expect = e-134
 Identities = 329/911 (36%), Positives = 464/911 (50%), Gaps = 91/911 (9%)

Query: 205  KALETIAVAFSSTVSEFLMGEV---DSSTLLAVPPGDSSQSMESLYGPGSEGTPPSLEDC 261
            ++L+ + ++  +   E L G+    +       P    +       GP  EG  P     
Sbjct: 23   RSLDNLEISLGNVTLEMLAGDPLLSEDPEPDKTPTATVTNEASCWSGPSPEGPVP----- 77

Query: 262  DAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLISYLEKRTTLEMEFAKGLQKIA 321
                L  EE+D+ L R +GGVDAAL YAK  ++Y K+L+++ EKR + E+EFAK   KIA
Sbjct: 78   ----LTGEELDLRLIRTKGGVDAALEYAKTWSRYAKELLAWTEKRASYELEFAKSTMKIA 133

Query: 322  HNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGTLQTQTFMQPLTLRRLEHEKRR 381
               + S+ Q+ HMPL  IY+L LE DL  G   ++ V   Q + + QPL  +R E EK R
Sbjct: 134  EAGKVSIQQQSHMPLQYIYTLFLEHDLSLGTLAMETVAQ-QKRDYYQPLAAKRTEIEKWR 192

Query: 382  KEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKARFLVAKAEEEQAGSAPGAGSTA 441
            KE KE W + Q+++ EA   LR+A+  YVQR ED      L A+++     SAP A    
Sbjct: 193  KEFKEQWMKEQKRMNEAVQALRRAQLQYVQRSED------LRARSQGSPEDSAPQASPGP 246

Query: 442  TKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQT 501
            +K  ++RRR  EEA+ KA+EA A Y+ CV +A  ++Q+LE  K   +  +++++ Q D+ 
Sbjct: 247  SKQQERRRRSREEAQAKAQEAEALYQACVREANARQQDLEIAKQRIVSHVRKLVFQGDEV 306

Query: 502  IKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQYASHVRQLQRDQEPDVH--YDF 559
            ++  T+S + +   Q    P  F  L E    ++PGQ+Y   VR L+ +  P     + F
Sbjct: 307  LRRVTLSLFGLRGAQAERGPRAFAALAECCAPFEPGQRYQEFVRALRPEAPPPPPPAFSF 366

Query: 560  EPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCT----EGTPAKDHRAGRGHQ 615
            +  + +   SP+   +K S  +       +A   P E   T    +GTP        G  
Sbjct: 367  QEFLPSLNSSPLDIRKKLSGPLPPRLDENSAEPGPWEDPGTGWRWQGTPGPTP----GSD 422

Query: 616  VHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTE-ELVDPDGGAGASAFEQAD 674
            V      S S S       PGAG  ++  + SS+GT SS + E  DPD G G        
Sbjct: 423  VDSVGGGSESRSLDSPTSSPGAGT-RQLVKASSTGTESSDDFEERDPDLGDGLE------ 475

Query: 675  LNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLA 734
             NG+           PF    LS AA+TH+LR+LR PAKCREC +++   G ECEEC L 
Sbjct: 476  -NGL---------GSPFGKWTLSSAAQTHQLRRLRGPAKCRECEAFMV-SGTECEECFLT 524

Query: 735  CHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKG 794
            CHK+CLETL I CGH++L  R  LFG DF    R  P+ VPF+V KC  EIE RAL  +G
Sbjct: 525  CHKRCLETLLILCGHRRLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQG 584

Query: 795  IYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELV 854
            IYRV+G + RVE+LCQAFENG+ LVELS  SPHD+S+VLK +L++L EP+I F LY   +
Sbjct: 585  IYRVSGSRVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFI 644

Query: 855  GLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLR 914
             LAK           A  G   G+ S +  V  +  L+ LL  LP  N  +L++L+ HL 
Sbjct: 645  SLAK--------TLHADPGDDPGTPSPSPEVIRS--LKTLLVQLPDSNYNTLRHLVAHLF 694

Query: 915  RIVEVEQDNKMTPGNLGIVFGPTLLRPRP---TEATVSLSSLVDYPHQARVIETLIVHYG 971
            R+     +NKM+  NLGIVFGPTLLRP       + + ++ L+D  HQA+++E LIVHY 
Sbjct: 695  RVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYE 754

Query: 972  LVF--EEEPEET-PGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGCRESRVVSN 1028
             +F  +E P+ T P  QD S                            A G   +     
Sbjct: 755  QIFGMDELPQATEPPPQDSS---------------------------PAPGPLTTSSQPP 787

Query: 1029 DSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDG 1088
                D +    +L+S       H S LEQ  +    E+ +      E+  E T    G+ 
Sbjct: 788  PPHLDPDSQPPVLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQREDVAEDTKDGGGEV 847

Query: 1089 DEDGPAQQLSG 1099
               GP   L G
Sbjct: 848  SSQGPEDSLLG 858


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  127 bits (319), Expect = 6e-29
 Identities = 89/282 (31%), Positives = 147/282 (52%), Gaps = 34/282 (12%)

Query: 701 RTH--RLRKLRTPAKCRECNSYVY---FQGAECEECCLACHKKCLETLAIQCGHKKLQGR 755
           +TH  ++   R P  C  C ++++    QG  C +C L  HK+C + +   C    L+  
Sbjct: 213 KTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDC-QPDLKRI 271

Query: 756 LQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENG 815
            +++  D +   ++     P +V  C+ EIE R L+++G+YRV+G    +E +  AF+  
Sbjct: 272 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 331

Query: 816 KELVELSQASPHDISNV---LKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASR 872
            E  ++S     DI+ +   LKLY R LP P+I++  Y + +  AK S   E        
Sbjct: 332 GEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADE-------- 383

Query: 873 GRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGI 932
                   EAV         E+L  LPP +  +L+YL+ HL+++   E+DN M   NLGI
Sbjct: 384 ------RLEAV--------HEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGI 429

Query: 933 VFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVF 974
           VFGPTL+RP P ++T  L++L D  +Q  +++ LI +  ++F
Sbjct: 430 VFGPTLMRP-PEDST--LTTLHDMRYQKLIVQILIENEDVLF 468


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  127 bits (319), Expect = 6e-29
 Identities = 89/282 (31%), Positives = 147/282 (52%), Gaps = 34/282 (12%)

Query: 701 RTH--RLRKLRTPAKCRECNSYVY---FQGAECEECCLACHKKCLETLAIQCGHKKLQGR 755
           +TH  ++   R P  C  C ++++    QG  C +C L  HK+C + +   C    L+  
Sbjct: 77  KTHNFKVHTFRGPHWCEYCANFMWGLIAQGVRCSDCGLNVHKQCSKHVPNDC-QPDLKRI 135

Query: 756 LQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENG 815
            +++  D +   ++     P +V  C+ EIE R L+++G+YRV+G    +E +  AF+  
Sbjct: 136 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 195

Query: 816 KELVELSQASPHDISNV---LKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASR 872
            E  ++S     DI+ +   LKLY R LP P+I++  Y + +  AK S   E        
Sbjct: 196 GEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADE-------- 247

Query: 873 GRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGI 932
                   EAV         E+L  LPP +  +L+YL+ HL+++   E+DN M   NLGI
Sbjct: 248 ------RLEAV--------HEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGI 293

Query: 933 VFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVF 974
           VFGPTL+RP P ++T  L++L D  +Q  +++ LI +  ++F
Sbjct: 294 VFGPTLMRP-PEDST--LTTLHDMRYQKLIVQILIENEDVLF 332


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score =  125 bits (315), Expect = 2e-28
 Identities = 88/290 (30%), Positives = 144/290 (49%), Gaps = 34/290 (11%)

Query: 693 HEGLSKAARTH--RLRKLRTPAKCRECNSYVY---FQGAECEECCLACHKKCLETLAIQC 747
           +E + K  + H  ++   R P  C  C ++++    QG +C +C L  HK+C + +   C
Sbjct: 196 NEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDC 255

Query: 748 GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEK 807
               L+   +++  D +   ++     P +V  C+ EIE R L ++G+YRV+G    +E 
Sbjct: 256 -KPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIED 314

Query: 808 LCQAFENGKELVELSQASPHD---ISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAE 864
           +  AF+   E  ++S     D   I+  LKLY R LP PLI++  Y + +  AK      
Sbjct: 315 VKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAK------ 368

Query: 865 AEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNK 924
                      D  E           L E L+ LPP +  +L+YL+ HL+R+   E++N 
Sbjct: 369 ---------IMDPDEQ-------LETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENL 412

Query: 925 MTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVF 974
           M   NLGIVFGPTL+R    +A   +++L D  +Q  V+E LI +  ++F
Sbjct: 413 MNAENLGIVFGPTLMRSPELDA---MAALNDIRYQRLVVELLIKNEDILF 459


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score =  125 bits (315), Expect = 2e-28
 Identities = 86/277 (31%), Positives = 138/277 (49%), Gaps = 32/277 (11%)

Query: 704 RLRKLRTPAKCRECNSYVY---FQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFG 760
           R+   R P  C  C ++++    QG +C +C L  HK+C + +   C    L+   +++ 
Sbjct: 183 RVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDC-KPDLKHVKKVYS 241

Query: 761 QDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVE 820
            D +   ++     P +V  C+ EIE R L ++G+YRV+G    +E +  AF+   E  +
Sbjct: 242 CDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKAD 301

Query: 821 LSQASPHD---ISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDG 877
           +S     D   I+  LKLY R LP PLI++  Y + +  AK                 D 
Sbjct: 302 ISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAK---------------IMDP 346

Query: 878 SESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPT 937
            E           L E L+ LPP +  +L+YL+ HL+R+   E++N M   NLGIVFGPT
Sbjct: 347 DEQ-------LETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPT 399

Query: 938 LLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVF 974
           L+R    +A   +++L D  +Q  V+E LI +  ++F
Sbjct: 400 LMRSPELDA---MAALNDIRYQRLVVELLIKNEDILF 433


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score =  117 bits (292), Expect = 8e-26
 Identities = 76/217 (35%), Positives = 112/217 (51%), Gaps = 27/217 (12%)

Query: 758 LFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFE-NGK 816
           +FG   S   +     VP+IV++CV E+E+R +   GIYR++GV T ++ L   F+ N K
Sbjct: 598 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 657

Query: 817 E-LVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELV-GLAKDSLKAEAEAKAASRGR 874
           + L+ LS    + I+  LKLY R+LPEPL++ RLY   + G+A     A+          
Sbjct: 658 DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENC------- 710

Query: 875 QDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVF 934
                           +  LLR LP  N  +  +LL HL+R+ E E  NKM+  NL  VF
Sbjct: 711 ----------------MMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVF 754

Query: 935 GPTLLRPRPTEATVSLSSLVD-YPHQARVIETLIVHY 970
           GPTLLRP   E+   L+S  D + H       ++++Y
Sbjct: 755 GPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYY 791


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score =  117 bits (292), Expect = 8e-26
 Identities = 76/217 (35%), Positives = 112/217 (51%), Gaps = 27/217 (12%)

Query: 758 LFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFE-NGK 816
           +FG   S   +     VP+IV++CV E+E+R +   GIYR++GV T ++ L   F+ N K
Sbjct: 644 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 703

Query: 817 E-LVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELV-GLAKDSLKAEAEAKAASRGR 874
           + L+ LS    + I+  LKLY R+LPEPL++ RLY   + G+A     A+          
Sbjct: 704 DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENC------- 756

Query: 875 QDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVF 934
                           +  LLR LP  N  +  +LL HL+R+ E E  NKM+  NL  VF
Sbjct: 757 ----------------MMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVF 800

Query: 935 GPTLLRPRPTEATVSLSSLVD-YPHQARVIETLIVHY 970
           GPTLLRP   E+   L+S  D + H       ++++Y
Sbjct: 801 GPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYY 837


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score =  117 bits (292), Expect = 8e-26
 Identities = 76/217 (35%), Positives = 112/217 (51%), Gaps = 27/217 (12%)

Query: 758 LFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFE-NGK 816
           +FG   S   +     VP+IV++CV E+E+R +   GIYR++GV T ++ L   F+ N K
Sbjct: 607 VFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 666

Query: 817 E-LVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELV-GLAKDSLKAEAEAKAASRGR 874
           + L+ LS    + I+  LKLY R+LPEPL++ RLY   + G+A     A+          
Sbjct: 667 DILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENC------- 719

Query: 875 QDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVF 934
                           +  LLR LP  N  +  +LL HL+R+ E E  NKM+  NL  VF
Sbjct: 720 ----------------MMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVF 763

Query: 935 GPTLLRPRPTEATVSLSSLVD-YPHQARVIETLIVHY 970
           GPTLLRP   E+   L+S  D + H       ++++Y
Sbjct: 764 GPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYY 800


>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
          Length = 2022

 Score =  111 bits (278), Expect = 3e-24
 Identities = 81/278 (29%), Positives = 128/278 (46%), Gaps = 34/278 (12%)

Query: 711  PAKCRECNSYVYFQGAE--CEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSH--- 765
            P  C +C SY++       C  C + CHKKC+  +   C +    GR    G +  H   
Sbjct: 1643 PQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYT--YGRKGEPGVEPGHFGV 1700

Query: 766  ---AARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELS 822
               +  S    VP +++K +  +E   L T+G+YR +G   R  +L QA +     V+L 
Sbjct: 1701 CVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLE 1760

Query: 823  QASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEA 882
                H I+ VLK +LR+LPEPL++F  Y + +                 R  +   + E 
Sbjct: 1761 NFPIHAITGVLKQWLRELPEPLMTFAQYGDFL-----------------RAVELPEKQEQ 1803

Query: 883  VAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPR 942
            +A   A     +L  LP  N  SL+ L+ HL ++  +E  N+M+PG L I+F P LL  R
Sbjct: 1804 LAAIYA-----VLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLL--R 1856

Query: 943  PTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEE 980
              + +  L+S+ D       +E LI      ++ + EE
Sbjct: 1857 CPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEE 1894


>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
          Length = 2157

 Score =  111 bits (278), Expect = 3e-24
 Identities = 81/278 (29%), Positives = 128/278 (46%), Gaps = 34/278 (12%)

Query: 711  PAKCRECNSYVYFQGAE--CEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSH--- 765
            P  C +C SY++       C  C + CHKKC+  +   C +    GR    G +  H   
Sbjct: 1643 PQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYT--YGRKGEPGVEPGHFGV 1700

Query: 766  ---AARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELS 822
               +  S    VP +++K +  +E   L T+G+YR +G   R  +L QA +     V+L 
Sbjct: 1701 CVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLE 1760

Query: 823  QASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEA 882
                H I+ VLK +LR+LPEPL++F  Y + +                 R  +   + E 
Sbjct: 1761 NFPIHAITGVLKQWLRELPEPLMTFAQYGDFL-----------------RAVELPEKQEQ 1803

Query: 883  VAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPR 942
            +A   A     +L  LP  N  SL+ L+ HL ++  +E  N+M+PG L I+F P LL  R
Sbjct: 1804 LAAIYA-----VLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLL--R 1856

Query: 943  PTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEE 980
              + +  L+S+ D       +E LI      ++ + EE
Sbjct: 1857 CPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEE 1894


>gi|4505507 oligophrenin 1 [Homo sapiens]
          Length = 802

 Score =  110 bits (276), Expect = 6e-24
 Identities = 73/208 (35%), Positives = 116/208 (55%), Gaps = 30/208 (14%)

Query: 778 VKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELS-QASPHDISNV---L 833
           V+KC+  IE + ++T+G+YR  G   +V+KL  AF + K   ++    S  DI  +   L
Sbjct: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSL 449

Query: 834 KLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRE 893
           K YLR L EP++++RL+ ELV  AK                     S+ +   L G +  
Sbjct: 450 KFYLRNLSEPVMTYRLHKELVSAAK---------------------SDNLDYRL-GAIHS 487

Query: 894 LLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSL 953
           L+  LP +NR  L+ L+RHL  + E  ++N MTP N+G++FGPTL+R +  E TV  +++
Sbjct: 488 LVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQ--EDTV--AAM 543

Query: 954 VDYPHQARVIETLIVHYGLVFEEEPEET 981
           ++   Q  V+E LI H+G ++   PEE+
Sbjct: 544 MNIKFQNIVVEILIEHFGKIYLGPPEES 571


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  108 bits (271), Expect = 2e-23
 Identities = 98/347 (28%), Positives = 151/347 (43%), Gaps = 35/347 (10%)

Query: 774  VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHD---IS 830
            VP IV  C   +E R L + GIYRV G    V  L +    G   + L      D   IS
Sbjct: 825  VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVIS 884

Query: 831  NVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGR 890
            ++LK + R+LPEPL +   Y+       D ++A     A  R R                
Sbjct: 885  SLLKSFFRKLPEPLFTDDKYN-------DFIEANRIEDARERMRT--------------- 922

Query: 891  LRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSL 950
            LR+L+RDLP     +L++L+ HL+ I +  + NKM P NL +VFGPTL+R      T  +
Sbjct: 923  LRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMV 982

Query: 951  SSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVY 1010
            + +   P + +++ETLI H    F +  EE  G +    ++  + V  + YL        
Sbjct: 983  THM---PDRYKIVETLIQHSDWFFSD--EEDKGERTPVGDKEPQAVPNIEYLLPNIGRTV 1037

Query: 1011 PLQEAAADGCRESRVVSNDSDSDLEE--ASELLSSSEASALGHLSFLEQQQSEASLEVAS 1068
            P  +  +D    S   S  S +  +E  A E+L+ S  SA+       +++ EA    +S
Sbjct: 1038 PPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNR---KRKKRREARGLGSS 1094

Query: 1069 GSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPP 1115
                  +E  +  A     G ++ P   L G    ++   L  P  P
Sbjct: 1095 TDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAP 1141


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score =  108 bits (269), Expect = 4e-23
 Identities = 76/201 (37%), Positives = 104/201 (51%), Gaps = 26/201 (12%)

Query: 750  KKLQGRLQ--LFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEK 807
            K++  R Q  +FG   +   +     VP+IV++CV EIERR +   GIYRV+GV T ++ 
Sbjct: 997  KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1056

Query: 808  LCQAFE-NGKEL-VELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEA 865
            L  AF+ N K++ V +S+   + I+  LKLY R+LPEPL +   Y              A
Sbjct: 1057 LKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNF-----------A 1105

Query: 866  EAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKM 925
            E  A S             VA    +  LL  LP  N  +  +LL HL+R+ E E  NKM
Sbjct: 1106 EGIALSD-----------PVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKM 1154

Query: 926  TPGNLGIVFGPTLLRPRPTEA 946
            +  NL  VFGPTLLRP   E+
Sbjct: 1155 SLHNLATVFGPTLLRPSEKES 1175



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 24/68 (35%), Positives = 30/68 (44%), Gaps = 6/68 (8%)

Query: 22  GSPSPQPSGELPRKDGADAVFPGPSLEPPA-----GSSGVKATGTLKRP-TSLSRHASAA 75
           G+  P+ S   P+   AD   P P+ EP A     GS G    GT +RP  + S      
Sbjct: 86  GASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDR 145

Query: 76  GFPLSGAA 83
           G P S AA
Sbjct: 146 GPPASVAA 153


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score =  108 bits (269), Expect = 4e-23
 Identities = 76/201 (37%), Positives = 104/201 (51%), Gaps = 26/201 (12%)

Query: 750  KKLQGRLQ--LFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEK 807
            K++  R Q  +FG   +   +     VP+IV++CV EIERR +   GIYRV+GV T ++ 
Sbjct: 1041 KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1100

Query: 808  LCQAFE-NGKEL-VELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEA 865
            L  AF+ N K++ V +S+   + I+  LKLY R+LPEPL +   Y              A
Sbjct: 1101 LKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNF-----------A 1149

Query: 866  EAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKM 925
            E  A S             VA    +  LL  LP  N  +  +LL HL+R+ E E  NKM
Sbjct: 1150 EGIALSD-----------PVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKM 1198

Query: 926  TPGNLGIVFGPTLLRPRPTEA 946
            +  NL  VFGPTLLRP   E+
Sbjct: 1199 SLHNLATVFGPTLLRPSEKES 1219



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 24/68 (35%), Positives = 30/68 (44%), Gaps = 6/68 (8%)

Query: 22  GSPSPQPSGELPRKDGADAVFPGPSLEPPA-----GSSGVKATGTLKRP-TSLSRHASAA 75
           G+  P+ S   P+   AD   P P+ EP A     GS G    GT +RP  + S      
Sbjct: 86  GASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDR 145

Query: 76  GFPLSGAA 83
           G P S AA
Sbjct: 146 GPPASVAA 153


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score =  107 bits (267), Expect = 6e-23
 Identities = 65/221 (29%), Positives = 119/221 (53%), Gaps = 31/221 (14%)

Query: 757 QLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGK 816
           Q+FG + ++  +     VP  VK C+  +E   L   GIYRV+G    ++KL  A  N  
Sbjct: 652 QVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAV-NHD 710

Query: 817 ELVELSQASPHDI---SNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRG 873
           E ++L+ +   DI   +  LK++ R+LPEPL +F  +++ V    +++K E   + A+  
Sbjct: 711 EKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFV----NAIKQEPRQRVAA-- 764

Query: 874 RQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIV 933
                            +++L+R LP  N+ ++Q L RHLRR++E  + N+MT  ++ IV
Sbjct: 765 -----------------VKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIV 807

Query: 934 FGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVF 974
           FGPTLL+P      +++ ++    +Q +++E +++    +F
Sbjct: 808 FGPTLLKPEKETGNIAVHTV----YQNQIVELILLELSSIF 844


>gi|208022687 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform b [Homo sapiens]
          Length = 759

 Score =  104 bits (260), Expect = 4e-22
 Identities = 71/214 (33%), Positives = 108/214 (50%), Gaps = 32/214 (14%)

Query: 772 DGVPF-IVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVEL-----SQAS 825
           D + F I++KC+  +E R +  +G+YR+ GV +RV+KL     + K   E      ++  
Sbjct: 386 DSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWE 445

Query: 826 PHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAV 885
              I++ LK YLR LP PL+ ++     +             KAA    Q+   SE    
Sbjct: 446 IKTITSALKTYLRMLPGPLMMYQFQRSFI-------------KAAKLENQESRVSE---- 488

Query: 886 ALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTE 945
                +  L+  LP +NR  LQ L+ HL  +    + N MT  NLG+VFGPTLLRP+  E
Sbjct: 489 -----IHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQ--E 541

Query: 946 ATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPE 979
            TV  ++++D   Q  VIE LI ++  +F   P+
Sbjct: 542 ETV--AAIMDIKFQNIVIEILIENHEKIFNTVPD 573



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 38/166 (22%), Positives = 67/166 (40%), Gaps = 12/166 (7%)

Query: 256 PSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLISYLEKRTTLEMEFAK 315
           P+LE  D  CL +      L+  E  +D    + K + K  K LIS L+  ++ + +FA 
Sbjct: 4   PALEFSDC-CLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFAD 62

Query: 316 GLQKIAHNCRQSVMQEPHMPL---LSIYSLALEQDLEFGHSMVQAVGTLQTQTFMQPLTL 372
            L +    C      +  M +   L  ++  L    +    M++      ++  + PL  
Sbjct: 63  SLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENA----SEVLITPLEK 118

Query: 373 RRLEHEKRRKEIKEAWHRAQRK---LQEAESNL-RKAKQGYVQRCE 414
            R E     KE K+ + +   K   + E   NL  K K+  +Q  +
Sbjct: 119 FRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEAD 164


>gi|7662208 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform a [Homo sapiens]
          Length = 814

 Score =  104 bits (260), Expect = 4e-22
 Identities = 71/214 (33%), Positives = 108/214 (50%), Gaps = 32/214 (14%)

Query: 772 DGVPF-IVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVEL-----SQAS 825
           D + F I++KC+  +E R +  +G+YR+ GV +RV+KL     + K   E      ++  
Sbjct: 386 DSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWE 445

Query: 826 PHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAV 885
              I++ LK YLR LP PL+ ++     +             KAA    Q+   SE    
Sbjct: 446 IKTITSALKTYLRMLPGPLMMYQFQRSFI-------------KAAKLENQESRVSE---- 488

Query: 886 ALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTE 945
                +  L+  LP +NR  LQ L+ HL  +    + N MT  NLG+VFGPTLLRP+  E
Sbjct: 489 -----IHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQ--E 541

Query: 946 ATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPE 979
            TV  ++++D   Q  VIE LI ++  +F   P+
Sbjct: 542 ETV--AAIMDIKFQNIVIEILIENHEKIFNTVPD 573



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 38/166 (22%), Positives = 67/166 (40%), Gaps = 12/166 (7%)

Query: 256 PSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLISYLEKRTTLEMEFAK 315
           P+LE  D  CL +      L+  E  +D    + K + K  K LIS L+  ++ + +FA 
Sbjct: 4   PALEFSDC-CLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFAD 62

Query: 316 GLQKIAHNCRQSVMQEPHMPL---LSIYSLALEQDLEFGHSMVQAVGTLQTQTFMQPLTL 372
            L +    C      +  M +   L  ++  L    +    M++      ++  + PL  
Sbjct: 63  SLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENA----SEVLITPLEK 118

Query: 373 RRLEHEKRRKEIKEAWHRAQRK---LQEAESNL-RKAKQGYVQRCE 414
            R E     KE K+ + +   K   + E   NL  K K+  +Q  +
Sbjct: 119 FRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEAD 164


>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
          Length = 786

 Score =  104 bits (260), Expect = 4e-22
 Identities = 68/210 (32%), Positives = 109/210 (51%), Gaps = 31/210 (14%)

Query: 777 IVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHD-----ISN 831
           I++KC+  +E R +  +G+YRV GV ++V++L     + K   E+   +  D     I++
Sbjct: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITS 457

Query: 832 VLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRL 891
            LK YLR LPEPL+++ L+ + +  AK                    ES   A+      
Sbjct: 458 ALKQYLRSLPEPLMTYELHGDFIVPAKSG----------------SPESRVNAIHF---- 497

Query: 892 RELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLS 951
             L+  LP +N+  L  L++HL  +    + N MT  NLG+VFGPTL+RP+  E TV  +
Sbjct: 498 --LVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQ--EETV--A 551

Query: 952 SLVDYPHQARVIETLIVHYGLVFEEEPEET 981
           +L+D   Q  V+E LI ++  +F   P+ T
Sbjct: 552 ALMDLKFQNIVVEILIENHEKIFRTPPDTT 581


>gi|156119615 myosin IXA [Homo sapiens]
          Length = 2548

 Score =  104 bits (259), Expect = 5e-22
 Identities = 80/263 (30%), Positives = 120/263 (45%), Gaps = 32/263 (12%)

Query: 711  PAKCRECNSYVYF--QGAECEECCLACHKKCLETLAIQCGHK---KLQGRLQLFGQDFSH 765
            P  C  C+S ++   + + C+ C  ACHKKC      +C  K   +L  R   FG + S 
Sbjct: 2010 PTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQ--FGVELSR 2067

Query: 766  AARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQAS 825
               S    VP +V+K +  IE   L T+GIYR +G   ++++L Q  +   E V L   +
Sbjct: 2068 LT-SEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYN 2126

Query: 826  PHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAV 885
             H I++V K +LR LP PL++F LY E +           E K   RG            
Sbjct: 2127 IHVIASVFKQWLRDLPNPLMTFELYEEFL-----RAMGLQERKETIRG------------ 2169

Query: 886  ALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTE 945
                 +  ++  L   +  +L+ L+ HL RI   E  N+M+   L IVF P +LR   T 
Sbjct: 2170 -----VYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDT- 2223

Query: 946  ATVSLSSLVDYPHQARVIETLIV 968
             T  L S+ D       +E ++V
Sbjct: 2224 -TDPLQSVQDISKTTTCVELIVV 2245


>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
           sapiens]
          Length = 735

 Score =  103 bits (258), Expect = 7e-22
 Identities = 77/207 (37%), Positives = 100/207 (48%), Gaps = 29/207 (14%)

Query: 771 PDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHD-- 828
           P  VP I++KCV +IERR LR  G+YR+ G     ++L  AFE     V LS+    D  
Sbjct: 410 PGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDIN 469

Query: 829 -ISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVAL 887
            I+ +LK YLR+LP PLI+  LY           K   EA A     +    +E      
Sbjct: 470 VITGILKDYLRELPTPLITQPLY-----------KVVLEAMARDPPNRVPPTTEGT---- 514

Query: 888 AGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLL-------R 940
               R LL  LP   RA+L  LL HLR +      N+MTP NL + FGP LL       R
Sbjct: 515 ----RGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTR 570

Query: 941 PRPTEATVSLSSLVDYPHQARVIETLI 967
           PR   +   L+S VD+ H   V+  L+
Sbjct: 571 PRARSSGPGLASAVDFKHHIEVLHYLL 597


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score =  100 bits (249), Expect = 8e-21
 Identities = 66/226 (29%), Positives = 110/226 (48%), Gaps = 30/226 (13%)

Query: 757 QLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGK 816
           Q+FG             VP+ VK+C+  +E+R L   GIYRV+G    ++KL +   N +
Sbjct: 277 QIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKL-RFIVNQE 335

Query: 817 ELVELSQASPHDI---SNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRG 873
           E + L  +   DI   +  LK++ R+LPEPL  +  + + V               A + 
Sbjct: 336 EKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFV--------------EAIKK 381

Query: 874 RQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIV 933
           + + +  EAV        + L++ LPP NR +++ L  HL +IV     N M+  +LGIV
Sbjct: 382 QDNNTRIEAV--------KSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV 433

Query: 934 FGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPE 979
           FGPTLLR       +++  +    +Q ++ E ++  Y  +F  E +
Sbjct: 434 FGPTLLRAENETGNMAIHMV----YQNQIAELMLSEYSKIFGSEED 475


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 67/212 (31%), Positives = 99/212 (46%), Gaps = 28/212 (13%)

Query: 774  VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHD---IS 830
            +P IV  C   +E R L   GIYRV G    +  + +    G   +++      D   IS
Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220

Query: 831  NVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGR 890
            ++LK + R+LPEPL +   Y + +         EA  K     R                
Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFI---------EANRKEDPLDRLK-------------T 1258

Query: 891  LRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSL 950
            L+ L+ DLP  +  +L++L  HL+ + E  + NKM P NL IVFGPTL+R      T  +
Sbjct: 1259 LKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMV 1318

Query: 951  SSLVDYPHQARVIETLIVHYGLVFEEEPEETP 982
            + +   P Q +++ETLI H+   F EE  E P
Sbjct: 1319 THM---PDQYKIVETLIQHHDWFFTEEGAEEP 1347


>gi|54860079 nadrin isoform 1 [Homo sapiens]
          Length = 881

 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 67/248 (27%), Positives = 112/248 (45%), Gaps = 27/248 (10%)

Query: 736 HKKCL----ETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALR 791
           H+K L    +TL     H+        FG       + +   +   ++ CV  +    ++
Sbjct: 223 HRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMK 282

Query: 792 TKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYH 851
            +G++R+    ++++KL  A +     ++   + PH ++  LK YLR+LPEPL++F LY 
Sbjct: 283 EEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYE 342

Query: 852 ELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLR 911
           E   +        A  +   +  QD              L    + LPP+N  + +YL++
Sbjct: 343 EWTQV--------ASVQDQDKKLQD--------------LWRTCQKLPPQNFVNFRYLIK 380

Query: 912 HLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYG 971
            L ++ +    NKMTP N+ IV GP LL  R  E T++  +     H   VIE +I H  
Sbjct: 381 FLAKLAQTSDVNKMTPSNIAIVLGPNLLWAR-NEGTLAEMAAATSVHVVAVIEPIIQHAD 439

Query: 972 LVFEEEPE 979
             F EE E
Sbjct: 440 WFFPEEVE 447


>gi|54860105 nadrin isoform 2 [Homo sapiens]
          Length = 803

 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 67/248 (27%), Positives = 112/248 (45%), Gaps = 27/248 (10%)

Query: 736 HKKCL----ETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALR 791
           H+K L    +TL     H+        FG       + +   +   ++ CV  +    ++
Sbjct: 223 HRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMK 282

Query: 792 TKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYH 851
            +G++R+    ++++KL  A +     ++   + PH ++  LK YLR+LPEPL++F LY 
Sbjct: 283 EEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYE 342

Query: 852 ELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLR 911
           E   +        A  +   +  QD              L    + LPP+N  + +YL++
Sbjct: 343 EWTQV--------ASVQDQDKKLQD--------------LWRTCQKLPPQNFVNFRYLIK 380

Query: 912 HLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYG 971
            L ++ +    NKMTP N+ IV GP LL  R  E T++  +     H   VIE +I H  
Sbjct: 381 FLAKLAQTSDVNKMTPSNIAIVLGPNLLWAR-NEGTLAEMAAATSVHVVAVIEPIIQHAD 439

Query: 972 LVFEEEPE 979
             F EE E
Sbjct: 440 WFFPEEVE 447


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 75/272 (27%), Positives = 128/272 (47%), Gaps = 32/272 (11%)

Query: 751  KLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQ 810
            K +G    FG D +    S+   VP+++K C   IE   +   GIYR++GV + +++L Q
Sbjct: 11   KRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQ 69

Query: 811  AFENGK--ELV-ELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEA 867
             F + +  +L  E+     H + ++ KLY R+LP PL+++ LY +               
Sbjct: 70   EFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFT------------- 116

Query: 868  KAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP 927
            +A S   ++G            R++ ++++LPP +  +L+YL+RHL  I        M  
Sbjct: 117  EAVSHCPEEGQ---------LARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHA 167

Query: 928  GNLGIVFGPTLLRPRPTEAT--VSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQ 985
             NL +V+ P LLR +  EAT     ++ +    Q  VIE ++ H   +F       PG  
Sbjct: 168  RNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFN---NGAPGSL 224

Query: 986  DESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA 1017
            +   N+     + +P L     +V  L+EA A
Sbjct: 225  ENDENRPIMKSLTLPALSLPMKLV-SLEEAQA 255


>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
           sapiens]
          Length = 874

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 67/227 (29%), Positives = 113/227 (49%), Gaps = 35/227 (15%)

Query: 778 VKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKEL----VELSQASPHDISNVL 833
           V+KC+  +E R +   G+YR+ GV ++V+KL     + K      +++       I++ L
Sbjct: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457

Query: 834 KLYLRQLPEPLISFRLYHE-LVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLR 892
           K YLR L EPL++++L+ + ++ +  D      EA  A                      
Sbjct: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHA---------------------- 495

Query: 893 ELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSS 952
            L+  LP +NR  L  L++HL ++    Q N MT  NLG++FGPTL+R +  E TV  ++
Sbjct: 496 -LVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQ--EETV--AA 550

Query: 953 LVDYPHQARVIETLIVHYGLVFEEEPEET---PGGQDESSNQRAEVV 996
           +++   Q  V+E LI HY  +F   P+ +   P  Q  S ++R   +
Sbjct: 551 MMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAI 597


>gi|149274655 synapse defective 1, Rho GTPase, homolog 2 [Homo
            sapiens]
          Length = 1194

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 70/224 (31%), Positives = 109/224 (48%), Gaps = 26/224 (11%)

Query: 758  LFGQDFSHAARSAPDG--VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENG 815
            +FG D          G  VP +++KC+ EIE+R  +  G+YR+ G     ++L +AFE  
Sbjct: 813  IFGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERD 872

Query: 816  KELVELSQASPHDIS---NVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASR 872
             + V L +    DI+    VLK YLR+LP PLI+ +LY  ++        A++  K +S 
Sbjct: 873  SKAVGLCENQYPDINVITGVLKDYLRELPSPLITKQLYEAVL-----DAMAKSPLKMSSN 927

Query: 873  GRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGI 932
            G ++        V       +LL  LP   +A+L+ LL HL+ +    + NKMT  NL +
Sbjct: 928  GCENDPGDSKYTV-------DLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAV 980

Query: 933  VFGPTLLRPRPTEAT---------VSLSSLVDYPHQARVIETLI 967
             FGP LL  R   +T           L+S +D+     V+  L+
Sbjct: 981  CFGPVLLSQRQEPSTHNNRVFTDSEELASALDFKKHIEVLHYLL 1024


>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
          Length = 946

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 159/718 (22%), Positives = 275/718 (38%), Gaps = 107/718 (14%)

Query: 296 MKDLISYLEKRTTLEMEFAKGLQKIAHNC------------RQSVMQEPHM-PLLSIYSL 342
           +++L  ++ +R  +E+E+++GL+K+A                QS  +EP +   L  +++
Sbjct: 46  LQELAEFMRRRAEVELEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAV 105

Query: 343 ALEQDLEFGHSMVQAVGTLQTQTFMQPLTLRRLEH-----EKRRKEIKEAWHRAQRKLQE 397
            L+      H+  Q+  +      +     +RL H      +  K+ ++   + Q +L E
Sbjct: 106 LLQ------HTRQQSRESAALSEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLE 159

Query: 398 AESNLRKAKQGYVQRCEDHDKARFLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKN 457
             S L+ AK+ Y     +   A   + +AE ++   A  +  T T    +   L + +  
Sbjct: 160 VVSELQTAKKTYQAYHMESVNAEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLK 219

Query: 458 KAEEAMATYRTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQT 517
           K    +   +     AK  + +L+ TK       +     S  ++ +A  +YY  +H   
Sbjct: 220 KGGRLVEKRQ-----AKFMEHKLKCTKA------RNEYLLSLASVNAAVSNYY--LHDV- 265

Query: 518 APLPVHFQMLCESSKLYDPGQQYASHVRQLQRDQEPDVHYDFEPHVSANAWSPVM-RARK 576
               +     C++      GQ   S+     R Q   V        +  A  P   +A+ 
Sbjct: 266 ----LDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAKV 321

Query: 577 SSFNVSDVARPEAAGSPPEEGG-----CTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGL 631
              + +    P      P +G      C E    +D    R   +         +++   
Sbjct: 322 LEVHATVFCPPLRFDYHPHDGDEVAEICVE-MELRDEILPRAQNIQSRLDRQTIETEE-- 378

Query: 632 DPGPGAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGM---TPELPVAVPS 688
                          +   T+ +  E+V  D G    +F+ +        T   P +  +
Sbjct: 379 ------------VNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQA 426

Query: 689 GPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQCG 748
           G  R  G  +   T  L KL+     R   + +  +  + +E      K+  E    Q  
Sbjct: 427 G--RRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYT 484

Query: 749 HKKLQGRLQ----------LFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRV 798
            +K Q   Q          LFG D     +S+   VP +V+ C+  I    L+ +GI+RV
Sbjct: 485 QRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRV 544

Query: 799 NGVKTRVEKLCQAFENGKE-LVELSQASPHD-ISNVLKLYLRQLPEPLISFRLYHELVGL 856
           +G + RV ++  AFE G++ LVE   A   D ++ VLKLY R L  PL    L+ EL  L
Sbjct: 545 SGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGEL--L 602

Query: 857 AKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRI 916
           A   L+A AE                        +  LL  LP      L+YL   L  +
Sbjct: 603 ASSELEATAER--------------------VEHVSRLLWRLPAPVLVVLRYLFTFLNHL 642

Query: 917 VEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVF 974
            +   +N M P NL + FGPTLL     +  V+L   V+     ++++TLIV    VF
Sbjct: 643 AQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVN-----QLVQTLIVQPDRVF 695


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,748,686
Number of Sequences: 37866
Number of extensions: 2346711
Number of successful extensions: 9969
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 350
Number of HSP's that attempted gapping in prelim test: 8801
Number of HSP's gapped (non-prelim): 1247
length of query: 1136
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1023
effective length of database: 13,968,660
effective search space: 14289939180
effective search space used: 14289939180
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.