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Search of human proteins with 47717139
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
sapiens]
(840 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ... 1722 0.0
gi|44917619 kelch domain containing 10 [Homo sapiens] 99 2e-20
gi|26190616 kelch domain containing 1 [Homo sapiens] 86 1e-16
gi|7019405 host cell factor C2 [Homo sapiens] 82 3e-15
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens] 81 4e-15
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 79 1e-14
gi|98986457 host cell factor 1 [Homo sapiens] 77 5e-14
gi|16945972 kelch domain containing 3 [Homo sapiens] 74 7e-13
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 73 1e-12
gi|7657301 kelch domain containing 2 [Homo sapiens] 71 4e-12
gi|56117834 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|56117832 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|56117830 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|56117828 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|4507183 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|56117836 speckle-type POZ protein [Homo sapiens] 67 7e-11
gi|48717263 speckle-type POZ protein-like [Homo sapiens] 66 1e-10
gi|40018614 DRE1 protein [Homo sapiens] 66 2e-10
gi|4557445 regulator of chromosome condensation and BTB domain c... 66 2e-10
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens] 65 3e-10
gi|11056006 kelch-like 12 [Homo sapiens] 65 3e-10
gi|55925604 kelch-like 18 [Homo sapiens] 64 4e-10
gi|62955044 F-box protein 42 [Homo sapiens] 63 1e-09
gi|21314675 kelch domain containing 4 [Homo sapiens] 61 5e-09
gi|148664209 kelch-like 10 [Homo sapiens] 60 6e-09
gi|46410931 attractin-like 1 [Homo sapiens] 59 1e-08
gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isof... 58 3e-08
gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isof... 58 3e-08
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 57 5e-08
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 57 5e-08
>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
sapiens]
Length = 840
Score = 1722 bits (4460), Expect = 0.0
Identities = 840/840 (100%), Positives = 840/840 (100%)
Query: 1 MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPC 60
MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPC
Sbjct: 1 MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPC 60
Query: 61 DEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYH 120
DEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYH
Sbjct: 61 DEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYH 120
Query: 121 HSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGA 180
HSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGA
Sbjct: 121 HSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGA 180
Query: 181 TVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKM 240
TVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKM
Sbjct: 181 TVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKM 240
Query: 241 FVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFG 300
FVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFG
Sbjct: 241 FVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFG 300
Query: 301 GAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKK 360
GAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKK
Sbjct: 301 GAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKK 360
Query: 361 SRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ 420
SRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ
Sbjct: 361 SRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ 420
Query: 421 FSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKITQARER 480
FSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKITQARER
Sbjct: 421 FSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKITQARER 480
Query: 481 LAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKIKYPRKGH 540
LAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKIKYPRKGH
Sbjct: 481 LAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKIKYPRKGH 540
Query: 541 VEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHCLN 600
VEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHCLN
Sbjct: 541 VEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHCLN 600
Query: 601 FVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLE 660
FVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLE
Sbjct: 601 FVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLE 660
Query: 661 GAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAF 720
GAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAF
Sbjct: 661 GAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAF 720
Query: 721 ESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA 780
ESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA
Sbjct: 721 ESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA 780
Query: 781 DKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI 840
DKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI
Sbjct: 781 DKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI 840
>gi|44917619 kelch domain containing 10 [Homo sapiens]
Length = 442
Score = 99.0 bits (245), Expect = 2e-20
Identities = 75/319 (23%), Positives = 141/319 (44%), Gaps = 23/319 (7%)
Query: 114 PPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKN-----DLFEYKFATGQWTEWKIE 168
PP R H V ++++VFGGY D + N++ +L+ Y FATG W + +
Sbjct: 88 PPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTD 147
Query: 169 GRLPVARSAHGATVYSDKLWIFAGYD---GNARLNDMWTIGLQDRELTCWEEVAQSGEIP 225
G +P ++ ++ + L +F G G + ND+ ++ + W ++ G+ P
Sbjct: 148 GYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKR---WALLSCRGKKP 204
Query: 226 PSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRY 285
+A+ ++VF G +G + +L + + + WT++ +L S P+ RY
Sbjct: 205 SRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNL---SCDLPEERY 261
Query: 286 GHTMVAFDRHLYVFGGAADNTL--PNELHCYDVDFQTWEVVQPSSDSEVGGAEVPE-RAC 342
H + + +Y+ GG T N++H Y+++ WE + ++G +C
Sbjct: 262 RHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSC 321
Query: 343 ASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVI-SDAMY 401
+ G D++ L+ T Q + + +P FH AAV + MY
Sbjct: 322 VQIKNDVFICGGYNGEVILGDIWKLNLQTF---QWVKLPATMPEPVYFHCAAVTPAGCMY 378
Query: 402 IFGGTVD--NNIRSGEMYR 418
I GG V+ N R+G +++
Sbjct: 379 IHGGVVNIHENKRTGSLFK 397
Score = 63.5 bits (153), Expect = 8e-10
Identities = 66/288 (22%), Positives = 112/288 (38%), Gaps = 31/288 (10%)
Query: 53 RWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDN------------GKTMLNDLLRFDV 100
R R PP RS H VA +YVFGG N + +L R+
Sbjct: 84 RGHRPPPA-------RSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHF 136
Query: 101 KDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATG 160
W + T G P S V++G+++ VFGG TG + S N ND+
Sbjct: 137 ATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGG-TGIPFGES---NGNDVHVCNVKYK 192
Query: 161 QWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQ 220
+W G+ P + + L++F G G D+ + L RE T +
Sbjct: 193 RWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNL 252
Query: 221 SGEIPPSCCNFPVAVCRDKMFVFSGQSG--AKITNNLFQFEFKDKTWTRIPTE-HLLRGS 277
S ++P +A ++++ G + A N + + + W I T+ H G
Sbjct: 253 SCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGF 312
Query: 278 PPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQ 325
P R H+ V +++ GG + ++ + ++ QT++ V+
Sbjct: 313 ---PAARRCHSCVQIKNDVFICGGYNGEVILGDI--WKLNLQTFQWVK 355
Score = 63.5 bits (153), Expect = 8e-10
Identities = 55/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 61 DEFVGARRSKHTVVAYKDAIYVFGGDN---GKTMLNDLLRFDVKDCSWCRAFTTGTPPAP 117
D ++ + ++V + + + VFGG G++ ND+ +VK W G P+
Sbjct: 147 DGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSR 206
Query: 118 RYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWK---IEGRLPVA 174
Y + + S++VFGG TG IYS DL + T +WT+ K + LP
Sbjct: 207 IYGQAMAIINGSLYVFGGTTGYIYS-------TDLHKLDLNTREWTQLKPNNLSCDLPEE 259
Query: 175 RSAHGATVYSDKLWIFAGYDGNARLNDMWT------IGLQDRELTCWEEVAQSGEIPPSC 228
R H +++I G WT I + E WEE+A P
Sbjct: 260 RYRHEIAHDGQRIYILGG-------GTSWTAYSLNKIHAYNLETNAWEEIATK---PHEK 309
Query: 229 CNFPVA-------VCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIP 269
FP A ++ +F+ G +G I ++++ + W ++P
Sbjct: 310 IGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLP 357
Score = 53.9 bits (128), Expect = 6e-07
Identities = 58/279 (20%), Positives = 107/279 (38%), Gaps = 38/279 (13%)
Query: 170 RLPVARSAHGATVYSDKLWIFAGYDGN------------ARLNDMWTIGLQDRELTCWEE 217
R P ARS H + L++F GY+ + ++W W +
Sbjct: 87 RPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATG---VWHQ 143
Query: 218 VAQSGEIPPSCCNFPVAVCRDKMFVFSGQS---GAKITNNLFQFEFKDKTWTRIPTEHLL 274
+ G +P + + + + + VF G G N++ K K W LL
Sbjct: 144 MGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWA------LL 197
Query: 275 RGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGG 334
P R YG M + LYVFGG +LH D++ + W ++P++ S
Sbjct: 198 SCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLS---- 253
Query: 335 AEVPERACASEEVPTLTYEERVGFKKSRDVFGL------DFGTTSAKQ-PTQPASEL--P 385
++PE E +G S + L + T + ++ T+P ++ P
Sbjct: 254 CDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFP 313
Query: 386 SGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCY 424
+ R H+ I + ++I GG + + G++++ +
Sbjct: 314 AARRCHSCVQIKNDVFICGG-YNGEVILGDIWKLNLQTF 351
Score = 43.5 bits (101), Expect = 8e-04
Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 8/93 (8%)
Query: 63 FVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHH- 121
F ARR H+ V K+ +++ GG NG+ +L D+ + +++ W + T P P Y H
Sbjct: 312 FPAARRC-HSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVK--LPATMPEPVYFHC 368
Query: 122 SAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFE 154
+AV M++ GG +I+ N K LF+
Sbjct: 369 AAVTPAGCMYIHGGVV-NIHEN---KRTGSLFK 397
>gi|26190616 kelch domain containing 1 [Homo sapiens]
Length = 406
Score = 85.9 bits (211), Expect = 1e-16
Identities = 61/224 (27%), Positives = 97/224 (43%), Gaps = 22/224 (9%)
Query: 118 RYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSA 177
R H AVV G+ ++V+GGY I N ++++ Y +G W +EG LP + S
Sbjct: 13 RSGHCAVVDGNFLYVWGGYVS-IEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSG 71
Query: 178 HGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELT-CWEEVAQ-SGEIPPSCCNFPVAV 235
+ KL+IF GYD N ++ + L+ R+ T WE++ G+ P V
Sbjct: 72 SCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWV 131
Query: 236 CRDKMFVFSGQSGAKITNNLFQFEFKDKTW------------------TRIPTEHLLRGS 277
+D++ F G + + F+ D +W T+ + ++G
Sbjct: 132 YKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGG 191
Query: 278 PPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTW 321
PPQ R HT Y+FGG T N+LH ++D TW
Sbjct: 192 -VPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTW 234
Score = 57.0 bits (136), Expect = 7e-08
Identities = 62/243 (25%), Positives = 90/243 (37%), Gaps = 49/243 (20%)
Query: 175 RSAHGATVYSDKLWIFAGY----DGNARL--NDMWTIGLQDRELTCWEEVAQSGEIPPSC 228
RS H A V + L+++ GY D L +++WT D + W GE+P S
Sbjct: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTY---DIDSGLWRMHLMEGELPASM 69
Query: 229 CNFPVAVCRDKMFVFSGQSGAKITNNLF--QFEFKDKT--WTRIPTEHLLRGSPPPPQRR 284
A K+++F G +N L+ +D+T W +I G PP P+ +
Sbjct: 70 SGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITD---FEGQPPTPRDK 126
Query: 285 YGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACAS 344
V DR +Y FGG C+DV +WE
Sbjct: 127 LS-CWVYKDRLIY-FGGYGCRRHSELQDCFDVHDASWE---------------------- 162
Query: 345 EEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFG 404
E++ + DV D T + QP P R H AV+ + YIFG
Sbjct: 163 ---------EQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFG 213
Query: 405 GTV 407
G V
Sbjct: 214 GRV 216
Score = 54.3 bits (129), Expect = 5e-07
Identities = 55/229 (24%), Positives = 83/229 (36%), Gaps = 36/229 (15%)
Query: 43 LNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKD 102
+N + + W ++ + R K + YKD + FGG + FDV D
Sbjct: 99 VNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHD 158
Query: 103 CSW-----------CRAFTT------------GTPPAPRYHHSAVVYGSSMFVFGGYTGD 139
SW F T G PP PR H+ V G+ ++FGG
Sbjct: 159 ASWEEQIFWGWHNDVHIFDTKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQ 218
Query: 140 IYSNSNLKNKNDLFEYKFATGQWT-EWKIEGRLPVARSAHGAT-VYSDKLWIFAGYDG-N 196
NDL T W+ I G P RS H T + DKL++ G N
Sbjct: 219 -------TRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPIADDKLFLCGGLSADN 271
Query: 197 ARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSG 245
L+D W + + CW+++ + P + +++ VF G
Sbjct: 272 IPLSDGW---IHNVTTNCWKQLTHLPKTRPRLWHTACLGKENEIMVFGG 317
>gi|7019405 host cell factor C2 [Homo sapiens]
Length = 792
Score = 81.6 bits (200), Expect = 3e-15
Identities = 80/296 (27%), Positives = 127/296 (42%), Gaps = 41/296 (13%)
Query: 71 HTVVAYKDAIYVFGG--DNGKTMLNDLLRFDVKDCSWCRAFT----TGTPPAPRYHHSAV 124
H V I VFGG + G+ N+L W + +G PP PR HS
Sbjct: 75 HGFVCDGTRILVFGGMVEYGRYS-NELYELQASRWLWKKVKPHPPPSGLPPCPRLGHSFS 133
Query: 125 VYGSSMFVFGGYTGDIY-SNSNL-KNKNDLFEYKFATGQ----WTEWKIEGRLPVARSAH 178
+YG+ ++FGG + SN+N+ + ND +E + G W+ +G +P R +H
Sbjct: 134 LYGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGVVPSPRESH 193
Query: 179 GATVY------SDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFP 232
A +Y S K+++F G G ARL+D+W + D E W + G +P
Sbjct: 194 TAVIYCKKDSGSPKMYVFGGMCG-ARLDDLWQL---DLETMSWSKPETKGTVPLPRSLHT 249
Query: 233 VAVCRDKMFVFSGQSGAKITN-------------NLFQFEFKDKT-WTRIPTEHLLRGSP 278
+V +KM++F G K N + F + D T WT + ++
Sbjct: 250 ASVIGNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYLNLDTTEWTTLVSDSQEDKKN 309
Query: 279 PPPQRRYGHTMVAFDRHLYVFGG--AADNTLPNELHCYDVDFQTWEVVQPSSDSEV 332
P+ R GH VA LY + G L +++ C D+ + E +P + S+V
Sbjct: 310 SRPRPRAGHCAVAIGTRLYFWSGRDGYKKALNSQVCCKDLWYLDTE--KPPAPSQV 363
Score = 75.9 bits (185), Expect = 1e-13
Identities = 68/268 (25%), Positives = 114/268 (42%), Gaps = 34/268 (12%)
Query: 54 WRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGT 113
WRR+ V R H VA ++ + +FGG N + + ++L ++ W G
Sbjct: 9 WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGN-EGIADELHVYNTATNQWFLPAVRGD 67
Query: 114 PPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWK----IEG 169
P H V G+ + VFGG + N+L+E + + W + K G
Sbjct: 68 IPPGCAAHGFVCDGTRILVFGGMV------EYGRYSNELYELQASRWLWKKVKPHPPPSG 121
Query: 170 RLPVARSAHGATVYSDKLWIFAGYDGNAR---------LNDMWTIGLQDRE-LTCWEEVA 219
P R H ++Y +K ++F G + LND + + LQ + W
Sbjct: 122 LPPCPRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPV 181
Query: 220 QSGEIP-PSCCNFPVAVCR-----DKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHL 273
G +P P + V C+ KM+VF G GA++ ++L+Q + + +W++ T
Sbjct: 182 TKGVVPSPRESHTAVIYCKKDSGSPKMYVFGGMCGARL-DDLWQLDLETMSWSKPET--- 237
Query: 274 LRGSPPPPQRRYGHTMVAFDRHLYVFGG 301
+G+ P P R HT +Y+FGG
Sbjct: 238 -KGTVPLP--RSLHTASVIGNKMYIFGG 262
Score = 65.5 bits (158), Expect = 2e-10
Identities = 52/159 (32%), Positives = 74/159 (46%), Gaps = 22/159 (13%)
Query: 57 LPPCDEFVGARRSKHTVVAY--KDA----IYVFGGDNGKTMLNDLLRFDVKDCSWCRAFT 110
+P V + R HT V Y KD+ +YVFGG G L+DL + D++ SW + T
Sbjct: 179 IPVTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGGMCG-ARLDDLWQLDLETMSWSKPET 237
Query: 111 TGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKN------DLFEY-KFATGQWT 163
GT P PR H+A V G+ M++FGG+ N+ + F Y T +WT
Sbjct: 238 KGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYLNLDTTEWT 297
Query: 164 -------EWKIEGRLPVARSAHGATVYSDKLWIFAGYDG 195
E K R P R+ H A +L+ ++G DG
Sbjct: 298 TLVSDSQEDKKNSR-PRPRAGHCAVAIGTRLYFWSGRDG 335
Score = 56.6 bits (135), Expect = 9e-08
Identities = 80/346 (23%), Positives = 121/346 (34%), Gaps = 81/346 (23%)
Query: 104 SWCRAFT-TGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQW 162
+W R + TG P R+ H AV M +FGG I ++L Y AT QW
Sbjct: 8 NWRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGI--------ADELHVYNTATNQW 59
Query: 163 TEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSG 222
+ G +P +AHG ++ +F G M G EL
Sbjct: 60 FLPAVRGDIPPGCAAHGFVCDGTRILVFGG---------MVEYGRYSNEL---------- 100
Query: 223 EIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQ 282
++ + W ++ G PP P
Sbjct: 101 ---------------------------------YELQASRWLWKKVKPHPPPSGLPPCP- 126
Query: 283 RRYGHTMVAFDRHLYVFGGAA------DNTLPNELH-CYDVDFQTWE-VVQPSSDSEVGG 334
R GH+ + Y+FGG A +N +P L+ Y+++ Q VV S G
Sbjct: 127 -RLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGV 185
Query: 335 AEVPERA------CASEE-VPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSG 387
P + C + P + + + D++ LD T S +P + +P
Sbjct: 186 VPSPRESHTAVIYCKKDSGSPKMYVFGGMCGARLDDLWQLDLETMSWSKP-ETKGTVPLP 244
Query: 388 RLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDY 433
R H A+VI + MYIFGG V + + E C +CT Y
Sbjct: 245 RSLHTASVIGNKMYIFGGWVPHKGENTE--TSPHDCEWRCTSSFSY 288
>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
Length = 372
Score = 81.3 bits (199), Expect = 4e-15
Identities = 55/213 (25%), Positives = 96/213 (45%), Gaps = 14/213 (6%)
Query: 78 DAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPR-YHHSAVVYGSSMFVFGGY 136
D I+VFGG N N L + + +W T PP+PR +H S+ G+ ++VFGG
Sbjct: 99 DRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG- 157
Query: 137 TGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGN 196
G+ + K +F+ T W++ + G P R H KL+I G G+
Sbjct: 158 -GERGAQPVQDTKLHVFDANTLT--WSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGD 214
Query: 197 ARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLF 256
+D+ I + D + W+++ +G P C +++F G + A + ++
Sbjct: 215 RFYDDLHCIDISDMK---WQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMY 271
Query: 257 QFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTM 289
Q+ +++ WT + + LL P R H+M
Sbjct: 272 QYHTEEQHWTLLKFDTLL------PPGRLDHSM 298
Score = 73.2 bits (178), Expect = 1e-12
Identities = 65/250 (26%), Positives = 108/250 (43%), Gaps = 34/250 (13%)
Query: 101 KDCSWCRAFTTGTPPAPRYHHSAVVYG-------SSMFVFGGYTGDIYSNSNLKNKNDLF 153
+ +W G P R HS +F+ GG +N N ++ +D+
Sbjct: 14 RKATWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGG------ANPN-RSFSDVH 66
Query: 154 EYKFATGQWTEWKIEGRLPVARSAHGATVYS---DKLWIFAGYDGNARLNDMWTIGLQDR 210
QW +G LP R H + + S D++W+F G + + N + + + R
Sbjct: 67 TMDLGKHQWDLDTCKGLLP--RYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETR 124
Query: 211 ELTCWEEVAQSGEIPPSCCNFPV--AVCRDKMFVFSG-QSGAKITNN--LFQFEFKDKTW 265
T E + PPS F A ++++VF G + GA+ + L F+ TW
Sbjct: 125 TWTTPEVTSP----PPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTW 180
Query: 266 TRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQ 325
++ T G+PP P R+GH MVA L++ GG A + ++LHC D+ W+ +
Sbjct: 181 SQPET----LGNPPSP--RHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLN 234
Query: 326 PSSDSEVGGA 335
P+ + G A
Sbjct: 235 PTGAAPAGCA 244
Score = 67.0 bits (162), Expect = 7e-11
Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 13/171 (7%)
Query: 68 RSKHTV-VAYKDAIYVFGG-DNGKTMLND--LLRFDVKDCSWCRAFTTGTPPAPRYHHSA 123
R+ HT A + +YVFGG + G + D L FD +W + T G PP+PR+ H
Sbjct: 139 RTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVM 198
Query: 124 VVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVY 183
V G+ +F+ GG GD + +DL + +W + G P +AH A
Sbjct: 199 VAAGTKLFIHGGLAGDRF-------YDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAM 251
Query: 184 SDKLWIFAGYDGNARLNDMWTIGLQDRELTC--WEEVAQSGEIPPSCCNFP 232
++IF G L+ M+ +++ T ++ + G + S C P
Sbjct: 252 GKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCIIP 302
Score = 66.2 bits (160), Expect = 1e-10
Identities = 53/255 (20%), Positives = 102/255 (40%), Gaps = 19/255 (7%)
Query: 75 AYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSS---MF 131
A + +++ GG N +D+ D+ W G PRY H++ + + ++
Sbjct: 45 AKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGL--LPRYEHASFIPSCTPDRIW 102
Query: 132 VFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAH-GATVYSDKLWIF 190
VFGG + N+N L T WT ++ P R+ H + ++L++F
Sbjct: 103 VFGGA-------NQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVF 155
Query: 191 AGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAK 250
G + A+ + + D W + G P + K+F+ G +G +
Sbjct: 156 GGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDR 215
Query: 251 ITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNE 310
++L + D W + L + P H+ VA +H+Y+FGG +
Sbjct: 216 FYDDLHCIDISDMKWQK------LNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDT 269
Query: 311 LHCYDVDFQTWEVVQ 325
++ Y + Q W +++
Sbjct: 270 MYQYHTEEQHWTLLK 284
Score = 62.0 bits (149), Expect = 2e-09
Identities = 63/257 (24%), Positives = 98/257 (38%), Gaps = 27/257 (10%)
Query: 162 WTEWKIEGRLPVARSAHGATVYSD-------KLWIFAGYDGNARLNDMWTIGLQDRELTC 214
W + G P AR H + K++I G + N +D+ T+ L +
Sbjct: 18 WYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQ--- 74
Query: 215 WEEVAQSGEIPP-SCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHL 273
W+ G +P +F + D+++VF G + + N L + +TWT
Sbjct: 75 WDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVT-- 132
Query: 274 LRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLP---NELHCYDVDFQTWEVVQPSSDS 330
SPPP R + + A LYVFGG P +LH +D + TW QP +
Sbjct: 133 ---SPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWS--QPET-- 185
Query: 331 EVGGAEVPERACASEEVPTLTYEER--VGFKKSRDVFGLDFGTTSAKQPTQPASELPSGR 388
+G P T + G + D+ +D Q P P+G
Sbjct: 186 -LGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKW-QKLNPTGAAPAGC 243
Query: 389 LFHAAAVISDAMYIFGG 405
H+A + +YIFGG
Sbjct: 244 AAHSAVAMGKHVYIFGG 260
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 79.3 bits (194), Expect = 1e-14
Identities = 45/157 (28%), Positives = 79/157 (50%), Gaps = 4/157 (2%)
Query: 665 EFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESML 724
E D+ +DG HKA+L R +F +MF+S+ ED + I I + S + + L
Sbjct: 368 ETADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNEDMKEVIEIDQF--SYPVYRAFL 425
Query: 725 RYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQ 784
+Y+Y V++PPED++ L Y NRL+ C+ ++ +TV+N + AA +
Sbjct: 426 QYLYTDTVDLPPEDAIGLLDLATSY--CENRLKKLCQHIIKRGITVENAFSLFSAAVRYD 483
Query: 785 ALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDII 821
A D++ C ++ T+V++ + LL + I
Sbjct: 484 AEDLEEFCFKFCINHLTEVTQTAAFWQMDGPLLKEFI 520
Score = 54.3 bits (129), Expect = 5e-07
Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 9/111 (8%)
Query: 521 FEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVL 580
+ +Q+LYTD + P ED + ++D LA S+ RL++LC+ I+ + ++N
Sbjct: 421 YRAFLQYLYTDTVDLPP----EDAIGLLD---LATSYCENRLKKLCQHIIKRGITVENAF 473
Query: 581 VVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIVRR 631
+ +A R L+E C F + +H +V F ++ PL+ E + +
Sbjct: 474 SLFSAAVRYDAEDLEEFCFKFCI--NHLTEVTQTAAFWQMDGPLLKEFIAK 522
>gi|98986457 host cell factor 1 [Homo sapiens]
Length = 2035
Score = 77.4 bits (189), Expect = 5e-14
Identities = 74/254 (29%), Positives = 101/254 (39%), Gaps = 40/254 (15%)
Query: 80 IYVFGG--DNGKTMLNDLLRFDVKDCSWCRAFT----TGTPPAPRYHHSAVVYGSSMFVF 133
+ VFGG + GK NDL W R G PP PR HS + G+ ++F
Sbjct: 94 LLVFGGMVEYGKYS-NDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLF 152
Query: 134 GGYTGDIY--SNSNLKNKNDLFEYKFATGQW-TEWKIE---GRLPVARSAHGATVYSD-- 185
GG D N+ + NDL+ + G W I G LP R +H A VY++
Sbjct: 153 GGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKD 212
Query: 186 ----KLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMF 241
KL I+ G G RL D+WT+ D + W + + SG P +KM+
Sbjct: 213 NKKSKLVIYGGMSG-CRLGDLWTL---DIDTLTWNKPSLSGVAPLPRSLHSATTIGNKMY 268
Query: 242 VFSG--------------QSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGH 287
VF G + K TN L W I + L P+ R GH
Sbjct: 269 VFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTL---EDNIPRARAGH 325
Query: 288 TMVAFDRHLYVFGG 301
VA + LY++ G
Sbjct: 326 CAVAINTRLYIWSG 339
Score = 67.8 bits (164), Expect = 4e-11
Identities = 84/373 (22%), Positives = 139/373 (37%), Gaps = 71/373 (19%)
Query: 53 RWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTG 112
RW+R+ V R H VA K+ I VFGG N + ++++L ++ W G
Sbjct: 18 RWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGN-EGIVDELHVYNTATNQWFIPAVRG 76
Query: 113 TPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIE---- 168
P + V G+ + VFGG Y K NDL+E + + +W K +
Sbjct: 77 DIPPGCAAYGFVCDGTRLLVFGGMVE--YG----KYSNDLYELQASRWEWKRLKAKTPKN 130
Query: 169 GRLPVARSAHGATVYSDKLWIFAGYDGNAR---------LNDMWTIGLQDRE-LTCWEEV 218
G P R H ++ +K ++F G ++ LND++ + L+ + W+
Sbjct: 131 GPPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIP 190
Query: 219 AQSGEIPPSCCNFPVAVC------RDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEH 272
G +PP + V + K+ ++ G SG ++ +L+ + TW + P+
Sbjct: 191 ITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRL-GDLWTLDIDTLTWNK-PS-- 246
Query: 273 LLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEV 332
L G P P R H+ +YVFGG W
Sbjct: 247 -LSGVAPLP--RSLHSATTIGNKMYVFGG-------------------W----------- 273
Query: 333 GGAEVPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHA 392
VP ++V T+E+ + LD +P R H
Sbjct: 274 ----VP---LVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHC 326
Query: 393 AAVISDAMYIFGG 405
A I+ +YI+ G
Sbjct: 327 AVAINTRLYIWSG 339
Score = 67.8 bits (164), Expect = 4e-11
Identities = 65/259 (25%), Positives = 103/259 (39%), Gaps = 31/259 (11%)
Query: 169 GRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSC 228
G +P R H A + + +F G GN + D + + + W A G+IPP C
Sbjct: 27 GPVPRPRHGHRAVAIKELIVVFGG--GNEGIVD--ELHVYNTATNQWFIPAVRGDIPPGC 82
Query: 229 CNFPVAVCRDKMFVFSGQ-SGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGH 287
+ ++ VF G K +N+L++ + W R+ + G PP P R GH
Sbjct: 83 AAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCP--RLGH 140
Query: 288 TMVAFDRHLYVFGGAAD------NTLPNELH-CYDVDFQTWEVVQPSSDSEVGGAEVPER 340
+ Y+FGG A+ N +P L+ Y ++ + V G P R
Sbjct: 141 SFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPR 200
Query: 341 ACASEEVPTLTYEERVGFKKSRDVFG------------LDFGTTSAKQPTQPASELPSGR 388
E + Y E+ K ++G LD T + +P+ + P R
Sbjct: 201 ----ESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLTWNKPSL-SGVAPLPR 255
Query: 389 LFHAAAVISDAMYIFGGTV 407
H+A I + MY+FGG V
Sbjct: 256 SLHSATTIGNKMYVFGGWV 274
Score = 63.5 bits (153), Expect = 8e-10
Identities = 43/144 (29%), Positives = 65/144 (45%), Gaps = 17/144 (11%)
Query: 68 RSKHTVVAY------KDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHH 121
R HT V Y K + ++GG +G L DL D+ +W + +G P PR H
Sbjct: 200 RESHTAVVYTEKDNKKSKLVIYGGMSG-CRLGDLWTLDIDTLTWNKPSLSGVAPLPRSLH 258
Query: 122 SAVVYGSSMFVFGGYTGDIYSNSNL-------KNKNDLFEYKFATGQWTEW---KIEGRL 171
SA G+ M+VFGG+ + + + K N L T W +E +
Sbjct: 259 SATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNI 318
Query: 172 PVARSAHGATVYSDKLWIFAGYDG 195
P AR+ H A + +L+I++G DG
Sbjct: 319 PRARAGHCAVAINTRLYIWSGRDG 342
Score = 44.3 bits (103), Expect = 5e-04
Identities = 37/140 (26%), Positives = 61/140 (43%), Gaps = 12/140 (8%)
Query: 277 SPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAE 336
S P P+ R+GH VA + VFGG + + +ELH Y+ W + D G A
Sbjct: 26 SGPVPRPRHGHRAVAIKELIVVFGGGNEGIV-DELHVYNTATNQWFIPAVRGDIPPGCAA 84
Query: 337 VPERACASEEVPTLTYEERVGFKK-SRDVFGL-----DFGTTSAKQPTQPASELPSGRLF 390
+ L + V + K S D++ L ++ AK P P RL
Sbjct: 85 Y---GFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCP--RLG 139
Query: 391 HAAAVISDAMYIFGGTVDNN 410
H+ +++ + Y+FGG +++
Sbjct: 140 HSFSLVGNKCYLFGGLANDS 159
>gi|16945972 kelch domain containing 3 [Homo sapiens]
Length = 382
Score = 73.6 bits (179), Expect = 7e-13
Identities = 67/269 (24%), Positives = 113/269 (42%), Gaps = 31/269 (11%)
Query: 53 RWRRLPPCDEFVGAR-------RSKHTVVAYKDAIYVFGGDNG-KTMLNDLLRFDVKDCS 104
RW +LPP + + R H+ V D + ++GG N + N L FDV
Sbjct: 55 RWTKLPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHK 114
Query: 105 WCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGY--TGDIYSNSNLKNKNDLFEYKFATGQW 162
W +GT P R HSA V G M++FGGY D +S ND+ + +T W
Sbjct: 115 WFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFS-------NDIHKLDTSTMTW 167
Query: 163 TEWKIEGRLPVARSAHGATVYSDKLWIFAG----YDGNARLNDMW--TIGLQDRELTCWE 216
T +G R H AT+ +++F G + N+++ I + D W
Sbjct: 168 TLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWL 227
Query: 217 EVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGA--KITNNLFQFEFKDKTWTRIPTEHLL 274
+ + +P + ++++F G + + ++L++F TW +I
Sbjct: 228 DCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEP---- 283
Query: 275 RGSPPPPQRRYGHTMVAFDRHLYVFGGAA 303
+G P P+RR +V + +FGG +
Sbjct: 284 KGKGPCPRRRQCCCIVG--DKIVLFGGTS 310
Score = 65.1 bits (157), Expect = 3e-10
Identities = 73/310 (23%), Positives = 126/310 (40%), Gaps = 35/310 (11%)
Query: 118 RYHHSAVVYGSSMFVFGGY-TGDIYSNSNLKNKNDLFEYKFATGQWTEWK-----IEGRL 171
R +H+AV G ++ FGGY +G+ Y + D+ + + +WT+ I G+
Sbjct: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLR---QIDVHIFNAVSLRWTKLPPVKSAIRGQA 70
Query: 172 PVA---RSAHGATVYSDKLWIFAGY-DGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPS 227
PV R H + D + ++ G D N ++ + + W SG +P +
Sbjct: 71 PVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHK---WFTPRVSGTVPGA 127
Query: 228 CCNFPVAVCRDKMFVFSG--QSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRY 285
V M++F G Q +N++ + + TWT I T +GSP + R
Sbjct: 128 RDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICT----KGSPA--RWRD 181
Query: 286 GHTMVAFDRHLYVFGGAADNTLP----NELHC-----YDVDFQTWEVVQPSSDSEVGGAE 336
H+ H+YVFGG AD P NE++C +D + W P+ G
Sbjct: 182 FHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRS 241
Query: 337 VPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVI 396
E Y R+ + D++ + + + K+ +P + P R ++
Sbjct: 242 HSAFGYNGELYIFGGYNARLN-RHFHDLWKFNPVSFTWKK-IEPKGKGPCPRRRQCCCIV 299
Query: 397 SDAMYIFGGT 406
D + +FGGT
Sbjct: 300 GDKIVLFGGT 309
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/193 (26%), Positives = 78/193 (40%), Gaps = 14/193 (7%)
Query: 226 PSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQ-----FEFKDKTWTRIP-TEHLLRGSPP 279
P N +++ F G + L Q F WT++P + +RG P
Sbjct: 12 PRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAP 71
Query: 280 P-PQRRYGHTMVAFDRHLYVFGGAADNT-LPNELHCYDVDFQTWEVVQPSSDSEVGGAEV 337
P RYGH+ V D + ++GG D N L+ +DV+ W P V GA
Sbjct: 72 VVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKW--FTPRVSGTVPGARD 129
Query: 338 PERACASEEVPTLT--YEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAV 395
AC ++ + YE++ S D+ LD T + S R FH+A +
Sbjct: 130 GHSACVLGKIMYIFGGYEQQADCF-SNDIHKLDTSTMTWTLICTKGSPA-RWRDFHSATM 187
Query: 396 ISDAMYIFGGTVD 408
+ MY+FGG D
Sbjct: 188 LGSHMYVFGGRAD 200
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 73.2 bits (178), Expect = 1e-12
Identities = 47/178 (26%), Positives = 84/178 (47%), Gaps = 6/178 (3%)
Query: 646 DIGTSLIQDMKAYLEGAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQ 705
+ SL++ +K + E F DI L+++G P HK +LA SSYF AMF S + E Q
Sbjct: 12 EYAVSLLEQLKLFYEQQ--LFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ 69
Query: 706 VNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLE 765
++ + + + ++ Y Y G + M L+ + + + C++ L
Sbjct: 70 THVHLRNV--DAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVED--VLQRCREYLI 125
Query: 766 MNVTVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDS 823
+ +N +++L AD ++K+ ++ H+FT V LS LL+DI+ S
Sbjct: 126 KKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSS 183
Score = 39.3 bits (90), Expect = 0.015
Identities = 26/120 (21%), Positives = 53/120 (44%), Gaps = 9/120 (7%)
Query: 510 HVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQY 569
HV +R +A ++++ + YT + + +Y+ A Q+ + Q CR+Y
Sbjct: 71 HVHLRNVDAATLQIIITYAYTGNLAMNDS-------TVEQLYETACFLQVEDVLQRCREY 123
Query: 570 IEASVDLQNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIV 629
+ ++ +N + + A +LK+ V E F V F +LS L+++I+
Sbjct: 124 LIKKINAENCVRLLSFADLFSCEELKQSAKRMV--EHKFTAVYHQDAFMQLSHDLLIDIL 181
>gi|7657301 kelch domain containing 2 [Homo sapiens]
Length = 406
Score = 71.2 bits (173), Expect = 4e-12
Identities = 78/321 (24%), Positives = 119/321 (37%), Gaps = 34/321 (10%)
Query: 115 PAPRYHHSAVVYGSSMFVFGGYTGDIYSN--SNLKNKNDLFEYKFATGQWTEWKIEGRLP 172
PA R H AV G MFV+GGY + + +L+ Y TG+W + EG +P
Sbjct: 29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVP 88
Query: 173 VARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQ--DRELTCWEEVAQSGEIPPSCCN 230
+ S A L++F G+ N + + + DR L WE + G P S
Sbjct: 89 PSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQ-WERIDCQGIPPSSKDK 147
Query: 231 FPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTR-------------IPTEHLLRGS 277
V V ++K+ F G L FEF + ++ + TE
Sbjct: 148 LGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQ 207
Query: 278 P----PPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVG 333
P P R H +VFGG + N+LH ++D W + P VG
Sbjct: 208 PITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVG 267
Query: 334 GAEVPERACASEEVPTLTYEERVGFKKSR----DVFGLDFGTTSAKQPTQPASELPSGRL 389
+ +S+ + GF + D + Q P +E P RL
Sbjct: 268 RSWHSLTPVSSDHLFLFG-----GFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKP--RL 320
Query: 390 FHAAAVISDA-MYIFGGTVDN 409
+H A + + +FGG +N
Sbjct: 321 WHTACASDEGEVIVFGGCANN 341
Score = 70.1 bits (170), Expect = 8e-12
Identities = 68/275 (24%), Positives = 109/275 (39%), Gaps = 43/275 (15%)
Query: 32 HSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGG------ 85
HS ++ ++ L+ + V +W R+ C + + K V YK+ + FGG
Sbjct: 110 HSRGNTNKFYMLDSRSTDRVLQWERID-CQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPE 168
Query: 86 ----------------DNGKTMLNDLLRF-DVKDCSWCRAFTTGTPPAPRYHHSAVVYGS 128
+ ND + D + +W + TTG P+PR H+ G+
Sbjct: 169 DKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGN 228
Query: 129 SMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGAT-VYSDKL 187
FVFGG D NDL T +W E +G PV RS H T V SD L
Sbjct: 229 RGFVFGGRYRD-------ARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHL 281
Query: 188 WIFAGYDGNAR-LNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQ 246
++F G+ + + L+D WT + E W + P + A ++ VF G
Sbjct: 282 FLFGGFTTDKQPLSDAWTYCISKNE---WIQFNHPYTEKPRLWHTACASDEGEVIVFGGC 338
Query: 247 SG-------AKITNNLFQFEFKDKTWTRIPTEHLL 274
+ A +N + F + K+ R+ E ++
Sbjct: 339 ANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVI 373
Score = 62.4 bits (150), Expect = 2e-09
Identities = 70/300 (23%), Positives = 115/300 (38%), Gaps = 37/300 (12%)
Query: 53 RWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCS----WCRA 108
RW+++ + V S V +Y+FGG + + N D + W R
Sbjct: 77 RWKKINTEGD-VPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERI 135
Query: 109 FTTGTPPAPRYHHSAVVYGSSMFVFGGY---------------TGDIYSNSNLKNKND-L 152
G PP+ + VY + + FGGY +++S+ + ND +
Sbjct: 136 DCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHV 195
Query: 153 FEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDREL 212
T W++ G+ P R+AH ++ ++F G +AR+ND+ + L E
Sbjct: 196 HILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWE- 254
Query: 213 TCWEEVAQSGEIPPS-CCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRI--P 269
W E+ G P + V D +F+F G + K + WT
Sbjct: 255 --WNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDK--------QPLSDAWTYCISK 304
Query: 270 TEHLLRGSPPPPQRRYGHTMVAFDR-HLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSS 328
E + P + R HT A D + VFGG A+N L + + + + VQP S
Sbjct: 305 NEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFS-VQPKS 363
>gi|56117834 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 56/177 (31%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Query: 664 AEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESM 723
+ F D L + G AHKAILAARS F AMF M E + + I ++ P + F+ M
Sbjct: 197 SRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEP--EVFKEM 254
Query: 724 LRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKT 783
+ +IY G+ + + L AA Y RL+ C+ L N++V+N +IL AD
Sbjct: 255 MCFIYTGKAPNLDKMADDLLAAADKYAL--ERLKVMCEDALCSNLSVENAAEILILADLH 312
Query: 784 QALDMKRHCLHIIVHQFTKVSKLPTLRSL---SQQLLLDIIDSLASHISDKQCAELG 837
A +K + I + + V + +S+ L+ + SLAS QC LG
Sbjct: 313 SADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLAS----AQCPFLG 365
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/214 (22%), Positives = 82/214 (38%), Gaps = 45/214 (21%)
Query: 389 LFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448
LF +V+ D++ I G N ++ P+C L ++ G LWE+ +F D
Sbjct: 157 LFCEVSVVQDSVNISGQNTMNMVK-----------VPECRLADELGGLWENSRFTDCCLC 205
Query: 449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPL 508
+ +E Q H AI+ ARS E +
Sbjct: 206 VAGQE--FQAHKAILAARSPVFSAMFEHEMEESKKN------------------------ 239
Query: 509 LHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 568
V I + E F+ +M F+YT K K +D+L D Y L RL+ +C
Sbjct: 240 -RVEINDVEPEVFKEMMCFIYTGKAPNLDK-MADDLLAAADKYALE------RLKVMCED 291
Query: 569 YIEASVDLQNVLVVCESAARLQLSQLKEHCLNFV 602
+ +++ ++N + A QLK ++F+
Sbjct: 292 ALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|56117832 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 56/177 (31%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Query: 664 AEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESM 723
+ F D L + G AHKAILAARS F AMF M E + + I ++ P + F+ M
Sbjct: 197 SRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEP--EVFKEM 254
Query: 724 LRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKT 783
+ +IY G+ + + L AA Y RL+ C+ L N++V+N +IL AD
Sbjct: 255 MCFIYTGKAPNLDKMADDLLAAADKYAL--ERLKVMCEDALCSNLSVENAAEILILADLH 312
Query: 784 QALDMKRHCLHIIVHQFTKVSKLPTLRSL---SQQLLLDIIDSLASHISDKQCAELG 837
A +K + I + + V + +S+ L+ + SLAS QC LG
Sbjct: 313 SADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLAS----AQCPFLG 365
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/214 (22%), Positives = 82/214 (38%), Gaps = 45/214 (21%)
Query: 389 LFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448
LF +V+ D++ I G N ++ P+C L ++ G LWE+ +F D
Sbjct: 157 LFCEVSVVQDSVNISGQNTMNMVK-----------VPECRLADELGGLWENSRFTDCCLC 205
Query: 449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPL 508
+ +E Q H AI+ ARS E +
Sbjct: 206 VAGQE--FQAHKAILAARSPVFSAMFEHEMEESKKN------------------------ 239
Query: 509 LHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 568
V I + E F+ +M F+YT K K +D+L D Y L RL+ +C
Sbjct: 240 -RVEINDVEPEVFKEMMCFIYTGKAPNLDK-MADDLLAAADKYALE------RLKVMCED 291
Query: 569 YIEASVDLQNVLVVCESAARLQLSQLKEHCLNFV 602
+ +++ ++N + A QLK ++F+
Sbjct: 292 ALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|56117830 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 56/177 (31%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Query: 664 AEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESM 723
+ F D L + G AHKAILAARS F AMF M E + + I ++ P + F+ M
Sbjct: 197 SRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEP--EVFKEM 254
Query: 724 LRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKT 783
+ +IY G+ + + L AA Y RL+ C+ L N++V+N +IL AD
Sbjct: 255 MCFIYTGKAPNLDKMADDLLAAADKYAL--ERLKVMCEDALCSNLSVENAAEILILADLH 312
Query: 784 QALDMKRHCLHIIVHQFTKVSKLPTLRSL---SQQLLLDIIDSLASHISDKQCAELG 837
A +K + I + + V + +S+ L+ + SLAS QC LG
Sbjct: 313 SADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLAS----AQCPFLG 365
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/214 (22%), Positives = 82/214 (38%), Gaps = 45/214 (21%)
Query: 389 LFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448
LF +V+ D++ I G N ++ P+C L ++ G LWE+ +F D
Sbjct: 157 LFCEVSVVQDSVNISGQNTMNMVK-----------VPECRLADELGGLWENSRFTDCCLC 205
Query: 449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPL 508
+ +E Q H AI+ ARS E +
Sbjct: 206 VAGQE--FQAHKAILAARSPVFSAMFEHEMEESKKN------------------------ 239
Query: 509 LHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 568
V I + E F+ +M F+YT K K +D+L D Y L RL+ +C
Sbjct: 240 -RVEINDVEPEVFKEMMCFIYTGKAPNLDK-MADDLLAAADKYALE------RLKVMCED 291
Query: 569 YIEASVDLQNVLVVCESAARLQLSQLKEHCLNFV 602
+ +++ ++N + A QLK ++F+
Sbjct: 292 ALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|56117828 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 56/177 (31%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Query: 664 AEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESM 723
+ F D L + G AHKAILAARS F AMF M E + + I ++ P + F+ M
Sbjct: 197 SRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEP--EVFKEM 254
Query: 724 LRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKT 783
+ +IY G+ + + L AA Y RL+ C+ L N++V+N +IL AD
Sbjct: 255 MCFIYTGKAPNLDKMADDLLAAADKYAL--ERLKVMCEDALCSNLSVENAAEILILADLH 312
Query: 784 QALDMKRHCLHIIVHQFTKVSKLPTLRSL---SQQLLLDIIDSLASHISDKQCAELG 837
A +K + I + + V + +S+ L+ + SLAS QC LG
Sbjct: 313 SADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLAS----AQCPFLG 365
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/214 (22%), Positives = 82/214 (38%), Gaps = 45/214 (21%)
Query: 389 LFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448
LF +V+ D++ I G N ++ P+C L ++ G LWE+ +F D
Sbjct: 157 LFCEVSVVQDSVNISGQNTMNMVK-----------VPECRLADELGGLWENSRFTDCCLC 205
Query: 449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPL 508
+ +E Q H AI+ ARS E +
Sbjct: 206 VAGQE--FQAHKAILAARSPVFSAMFEHEMEESKKN------------------------ 239
Query: 509 LHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 568
V I + E F+ +M F+YT K K +D+L D Y L RL+ +C
Sbjct: 240 -RVEINDVEPEVFKEMMCFIYTGKAPNLDK-MADDLLAAADKYALE------RLKVMCED 291
Query: 569 YIEASVDLQNVLVVCESAARLQLSQLKEHCLNFV 602
+ +++ ++N + A QLK ++F+
Sbjct: 292 ALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|4507183 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 56/177 (31%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Query: 664 AEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESM 723
+ F D L + G AHKAILAARS F AMF M E + + I ++ P + F+ M
Sbjct: 197 SRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEP--EVFKEM 254
Query: 724 LRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKT 783
+ +IY G+ + + L AA Y RL+ C+ L N++V+N +IL AD
Sbjct: 255 MCFIYTGKAPNLDKMADDLLAAADKYAL--ERLKVMCEDALCSNLSVENAAEILILADLH 312
Query: 784 QALDMKRHCLHIIVHQFTKVSKLPTLRSL---SQQLLLDIIDSLASHISDKQCAELG 837
A +K + I + + V + +S+ L+ + SLAS QC LG
Sbjct: 313 SADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLAS----AQCPFLG 365
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/214 (22%), Positives = 82/214 (38%), Gaps = 45/214 (21%)
Query: 389 LFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448
LF +V+ D++ I G N ++ P+C L ++ G LWE+ +F D
Sbjct: 157 LFCEVSVVQDSVNISGQNTMNMVK-----------VPECRLADELGGLWENSRFTDCCLC 205
Query: 449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPL 508
+ +E Q H AI+ ARS E +
Sbjct: 206 VAGQE--FQAHKAILAARSPVFSAMFEHEMEESKKN------------------------ 239
Query: 509 LHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 568
V I + E F+ +M F+YT K K +D+L D Y L RL+ +C
Sbjct: 240 -RVEINDVEPEVFKEMMCFIYTGKAPNLDK-MADDLLAAADKYALE------RLKVMCED 291
Query: 569 YIEASVDLQNVLVVCESAARLQLSQLKEHCLNFV 602
+ +++ ++N + A QLK ++F+
Sbjct: 292 ALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|56117836 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 67.0 bits (162), Expect = 7e-11
Identities = 56/177 (31%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Query: 664 AEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESM 723
+ F D L + G AHKAILAARS F AMF M E + + I ++ P + F+ M
Sbjct: 197 SRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEP--EVFKEM 254
Query: 724 LRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKT 783
+ +IY G+ + + L AA Y RL+ C+ L N++V+N +IL AD
Sbjct: 255 MCFIYTGKAPNLDKMADDLLAAADKYAL--ERLKVMCEDALCSNLSVENAAEILILADLH 312
Query: 784 QALDMKRHCLHIIVHQFTKVSKLPTLRSL---SQQLLLDIIDSLASHISDKQCAELG 837
A +K + I + + V + +S+ L+ + SLAS QC LG
Sbjct: 313 SADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLAS----AQCPFLG 365
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/214 (22%), Positives = 82/214 (38%), Gaps = 45/214 (21%)
Query: 389 LFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448
LF +V+ D++ I G N ++ P+C L ++ G LWE+ +F D
Sbjct: 157 LFCEVSVVQDSVNISGQNTMNMVK-----------VPECRLADELGGLWENSRFTDCCLC 205
Query: 449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPL 508
+ +E Q H AI+ ARS E +
Sbjct: 206 VAGQE--FQAHKAILAARSPVFSAMFEHEMEESKKN------------------------ 239
Query: 509 LHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 568
V I + E F+ +M F+YT K K +D+L D Y L RL+ +C
Sbjct: 240 -RVEINDVEPEVFKEMMCFIYTGKAPNLDK-MADDLLAAADKYALE------RLKVMCED 291
Query: 569 YIEASVDLQNVLVVCESAARLQLSQLKEHCLNFV 602
+ +++ ++N + A QLK ++F+
Sbjct: 292 ALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|48717263 speckle-type POZ protein-like [Homo sapiens]
Length = 392
Score = 66.2 bits (160), Expect = 1e-10
Identities = 45/134 (33%), Positives = 66/134 (49%), Gaps = 11/134 (8%)
Query: 666 FCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLR 725
F D + + G AHK++LAARS F AMF M E + + I ++ P + F+ M+R
Sbjct: 199 FTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDLDP--EVFKEMMR 256
Query: 726 YIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAAD---- 781
+IY G + + L AA Y RL+ C++ L N++V+NV L AD
Sbjct: 257 FIYTGRAPNLDKMADNLLAAADKYAL--ERLKVMCEEALCSNLSVENVADTLVLADLHSA 314
Query: 782 ---KTQALDMKRHC 792
K QA+D C
Sbjct: 315 EQLKAQAIDFINRC 328
Score = 53.5 bits (127), Expect = 8e-07
Identities = 51/223 (22%), Positives = 90/223 (40%), Gaps = 45/223 (20%)
Query: 389 LFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFV 448
LF +V+ D++ I G T N ++ P+C L ED G LWE+ +F D F
Sbjct: 157 LFCEVSVVQDSVNISGHTNTNTLK-----------VPECRLAEDLGNLWENTRFTDCSFF 205
Query: 449 LGEKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPL 508
+ +E + H +++ ARS E +
Sbjct: 206 VRGQE--FKAHKSVLAARSPVFNAMFEHEMEESKKN------------------------ 239
Query: 509 LHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQ 568
V I + + F+ +M+F+YT + P + D LL A + L RL+ +C +
Sbjct: 240 -RVEINDLDPEVFKEMMRFIYTGRA--PNLDKMADNLL-----AAADKYALERLKVMCEE 291
Query: 569 YIEASVDLQNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQV 611
+ +++ ++NV A QLK ++F+ + S Q+
Sbjct: 292 ALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQL 334
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 65.9 bits (159), Expect = 2e-10
Identities = 47/158 (29%), Positives = 76/158 (48%), Gaps = 4/158 (2%)
Query: 666 FCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLR 725
F D+ + ++G P H+A+L+A SSYF AMF + E ++ + I ++ +A E L+
Sbjct: 65 FTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGIL--AEAMECFLQ 122
Query: 726 YIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQA 785
Y+Y G+V + E+ YLF F + L+ C + LE + N L I AD
Sbjct: 123 YVYTGKVKITTENVQYLFETSSL--FQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL 180
Query: 786 LDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDS 823
+ C + + F VS+ L + L+D I S
Sbjct: 181 KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICS 218
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/188 (27%), Positives = 74/188 (39%), Gaps = 24/188 (12%)
Query: 139 DIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNAR 198
DI + N D++ Y Q W L R H V K+++ GYDG R
Sbjct: 364 DILVSGGRINSRDVWIYN---SQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNR 420
Query: 199 LNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQ- 257
L+ ++ D W EVA E S V C K+FV G ++ Q
Sbjct: 421 LS---SVECYDSFSNRWTEVAPLKEAVSSPA---VTSCVGKLFVIGGGPDDNTCSDKVQS 474
Query: 258 FEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVD 317
++ + +W LLR + P +R T V+ + +YV GG L ++CYD
Sbjct: 475 YDPETNSW-------LLRAAIPIAKRCI--TAVSLNNLIYVAGG-----LTKAIYCYDPV 520
Query: 318 FQTWEVVQ 325
W VQ
Sbjct: 521 EDYWMHVQ 528
Score = 39.7 bits (91), Expect = 0.012
Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 9/119 (7%)
Query: 511 VAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYI 570
V I A E +Q++YT K+K E+V + + L FQ+ L C +++
Sbjct: 107 VEINGILAEAMECFLQYVYTGKVKIT----TENVQYLFETSSL---FQISVLRDACAKFL 159
Query: 571 EASVDLQNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIV 629
E +D N L + A L L C NF ++ F V +EF L +++ +
Sbjct: 160 EEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQT--FEDVSQHEEFLELDKDELIDYI 216
Score = 31.2 bits (69), Expect = 4.2
Identities = 54/264 (20%), Positives = 97/264 (36%), Gaps = 41/264 (15%)
Query: 54 WRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGT 113
W+ L EF +S++ V A ++ I V GG + D+ ++ + W R +
Sbjct: 342 WKSLAKLPEFT---KSEYAVCALRNDILVSGG---RINSRDVWIYNSQLNIWIRVASLNK 395
Query: 114 PPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFE-YKFATGQWTEWKIEGRLP 172
R+ H V ++V GGY G +N+ E Y + +WTE L
Sbjct: 396 G---RWRHKMAVLLGKVYVVGGYDG--------QNRLSSVECYDSFSNRWTE---VAPLK 441
Query: 173 VARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFP 232
A S+ T KL++ G + +D + D E W IP +
Sbjct: 442 EAVSSPAVTSCVGKLFVIGGGPDDNTCSD--KVQSYDPETNSW---LLRAAIPIAKRCIT 496
Query: 233 VAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAF 292
+ ++V G +T ++ ++ + W + R+ M
Sbjct: 497 AVSLNNLIYVAGG-----LTKAIYCYDPVEDYWMHVQNTF---------SRQENCGMSVC 542
Query: 293 DRHLYVFGGAADN-TLPNELHCYD 315
+ +Y+ GG +N + + CYD
Sbjct: 543 NGKIYILGGRRENGEATDTILCYD 566
Score = 30.0 bits (66), Expect = 9.3
Identities = 25/116 (21%), Positives = 48/116 (41%), Gaps = 14/116 (12%)
Query: 215 WEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLL 274
W+ +A+ E S + V R+ + V G+ ++ +++ + + W R+ + L
Sbjct: 342 WKSLAKLPEFTKS--EYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVAS--LN 394
Query: 275 RGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDS 330
+G R+ H M +YV GG + + CYD W V P ++
Sbjct: 395 KG-------RWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEA 443
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/161 (26%), Positives = 78/161 (48%), Gaps = 9/161 (5%)
Query: 668 DITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYI 727
D+ L+DG AHK +L R +F RS + ++ + + E S + + L Y+
Sbjct: 395 DLKFLVDGKYIYAHKVLLKIRCEHF----RSSLEDNEDDIVEMSEF--SYPVYRAFLEYL 448
Query: 728 YYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALD 787
Y +++ PE+++ L +Y NRL+ C+Q ++ + +N + +L AA K A D
Sbjct: 449 YTDSISLSPEEAVGLLDLATFYR--ENRLKKLCQQTIKQGICEENAIALLSAAVKYDAQD 506
Query: 788 MKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHI 828
++ C ++ T V++ + LL + I S AS +
Sbjct: 507 LEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFI-SKASRV 546
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/111 (22%), Positives = 52/111 (46%), Gaps = 9/111 (8%)
Query: 521 FEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVL 580
+ +++LYTD I E+ + ++D LA ++ RL++LC+Q I+ + +N +
Sbjct: 441 YRAFLEYLYTDSISLSP----EEAVGLLD---LATFYRENRLKKLCQQTIKQGICEENAI 493
Query: 581 VVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIVRR 631
+ +A + L+E C F + +H V F + L+ + +
Sbjct: 494 ALLSAAVKYDAQDLEEFCFRFCI--NHLTVVTQTSGFAEMDHDLLKNFISK 542
>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
Length = 2778
Score = 64.7 bits (156), Expect = 3e-10
Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 40/298 (13%)
Query: 151 DLFEYKFATGQWTEW----KIEGRLPVARSAHGATVYS---DKLWIFAGYDGNARLNDMW 203
+L+ Y + +WT+ + G P RS H A +++ G D W
Sbjct: 1471 NLYRYSVSERRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTRDFW 1530
Query: 204 TIGLQDRELTCW--EEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNN-LFQFEF 260
+ L + W E+ Q+ E+P + A + + G S N L +++
Sbjct: 1531 VLNLTTLQ---WRQEKAPQTVELPAVAGHTLTARRGLSLLLVGGYSPENGFNQQLLEYQL 1587
Query: 261 KDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDR--HLYVFGG-------AADNTLPNEL 311
TW S PP YGH+ V + LYVFGG AA + L
Sbjct: 1588 ATGTWVSGAQ------SGTPPTGLYGHSAVYHEATDSLYVFGGFRFHVELAAPSPELYSL 1641
Query: 312 HCYDVDFQTWEVVQPSSDSE------VGGAEVPERACASEEVPTLTYEERVGFKKSRDVF 365
HC D +TW ++ PS ++ V G+ E+ + + E +K ++
Sbjct: 1642 HCPD---RTWSLLAPSQGAKRDRMRNVRGSSRGLGQVPGEQPGSWGFRE---VRKKMALW 1695
Query: 366 GLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSC 423
GT + P + P RLFHA+A++ D M + GG D + S ++ +Q +C
Sbjct: 1696 AALAGTGGFLEEISPHLKEPRPRLFHASALLGDTMVVLGGRSDPDEFSSDVLLYQVNC 1753
Score = 54.3 bits (129), Expect = 5e-07
Identities = 87/386 (22%), Positives = 141/386 (36%), Gaps = 82/386 (21%)
Query: 82 VFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIY 141
VFGG + L DL+ ++ +W ++ PA R+ H AV + S+ + GG D
Sbjct: 244 VFGGQDLNNALGDLVLYNFSANTW-ESWDLSPAPAARHSHVAVAWAGSLVLMGGELAD-- 300
Query: 142 SNSNLKNKNDLFEYK-FATGQWTEWKIEGRLPVARSAHG-------ATVYSDKLWIFAGY 193
+L ND++ + G W E P A S+ G A D +W++
Sbjct: 301 --GSL--TNDVWAFSPLGRGHW-----ELLAPPASSSSGPPGLAGHAAALVDDVWLYV-- 349
Query: 194 DGNARLNDMWTIGLQDRELTC-----WEEVAQSGEIPPSCCNFPVAVCRDK--MFVFSGQ 246
G +D+++ GL L WE+V +G PP+ + + V G
Sbjct: 350 SGGRTPHDLFSSGLFRFRLDSTSGGYWEQVIPAGGRPPAATGHSMVFHAPSRALLVHGGH 409
Query: 247 --SGAKIT---NNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGG 301
S A+ + N+ F WT + L+G P+ R HT ++ V+GG
Sbjct: 410 RPSTARFSVRVNSTELFHVDRHVWTTLKGRDGLQG----PRERAFHTASVLGNYMVVYGG 465
Query: 302 AADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKKS 361
+T E CY+ + + V GAE+ P T E R
Sbjct: 466 NV-HTHYQEEKCYEDGIFFYHL---GCHQWVSGAEL---------APPGTPEGR------ 506
Query: 362 RDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQF 421
+ PSGR H AAV+ ++ + G R G++ ++
Sbjct: 507 --------------------AAPPSGRYSHVAAVLGGSVLLVAGGYSGRPR-GDLMAYKV 545
Query: 422 SCY----PKCTLHEDYGRLWESRQFC 443
+ P H DY ++ C
Sbjct: 546 PPFVFQAPAPDYHLDYCSMYTDHSVC 571
Score = 38.9 bits (89), Expect = 0.020
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 4/70 (5%)
Query: 71 HTVVAYKD-AIYVFGGDNGKTMLND-LLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGS 128
HT+ A + ++ + GG + + N LL + + +W +GTPP Y HSAV + +
Sbjct: 1556 HTLTARRGLSLLLVGGYSPENGFNQQLLEYQLATGTWVSGAQSGTPPTGLYGHSAVYHEA 1615
Query: 129 --SMFVFGGY 136
S++VFGG+
Sbjct: 1616 TDSLYVFGGF 1625
Score = 37.4 bits (85), Expect = 0.058
Identities = 47/179 (26%), Positives = 65/179 (36%), Gaps = 21/179 (11%)
Query: 296 LYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEER 355
L VFGG N +L Y+ TWE S + V A A L E
Sbjct: 242 LAVFGGQDLNNALGDLVLYNFSANTWESWDLSPAPAARHSHV---AVAWAGSLVLMGGEL 298
Query: 356 VGFKKSRDVFG---LDFGTTSAKQPTQPASELPSGRLFHAAAVISDA-MYIFGGTVDNNI 411
+ DV+ L G P +S P G HAAA++ D +Y+ GG +++
Sbjct: 299 ADGSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDL 358
Query: 412 RSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWL 470
S ++RF+ L G WE G + GH + A SR L
Sbjct: 359 FSSGLFRFR--------LDSTSGGYWEQ------VIPAGGRPPAATGHSMVFHAPSRAL 403
Score = 33.1 bits (74), Expect = 1.1
Identities = 36/122 (29%), Positives = 50/122 (40%), Gaps = 25/122 (20%)
Query: 52 HRWRRLPPCDEFVGAR-RSKHTVVAYKDAIYVFGGD-----NGKTMLNDLLRFDVKDC-- 103
H W L D G R R+ HT + + V+GG+ + D + F C
Sbjct: 431 HVWTTLKGRDGLQGPRERAFHTASVLGNYMVVYGGNVHTHYQEEKCYEDGIFFYHLGCHQ 490
Query: 104 --SWCRAFTTGTP------PAPRYHH-SAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFE 154
S GTP P+ RY H +AV+ GS + V GGY+G + + DL
Sbjct: 491 WVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGYSG--------RPRGDLMA 542
Query: 155 YK 156
YK
Sbjct: 543 YK 544
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 64.7 bits (156), Expect = 3e-10
Identities = 64/274 (23%), Positives = 107/274 (39%), Gaps = 35/274 (12%)
Query: 54 WRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDV---KDCSWCRAFT 110
W LP + +R V+ D IYV GG +G++ L+ + D +D W ++
Sbjct: 309 WSFLPS----ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVW---YS 361
Query: 111 TGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGR 170
R A G ++V GG+ G S + ++ +W + G
Sbjct: 362 VAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNI----------DQWSMLGD 411
Query: 171 LPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCN 230
+ AR G V S ++ GYDG LN + ++ D W V +
Sbjct: 412 MQTAREGAGLVVASGVIYCLGGYDG---LNILNSVEKYDPHTGHWTNVTP---MATKRSG 465
Query: 231 FPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMV 290
VA+ D ++V G G +++ + + +WT + S P+ G T++
Sbjct: 466 AGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVT-------SMTTPRCYVGATVL 518
Query: 291 AFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVV 324
LY G N+L + + CYD +WEVV
Sbjct: 519 R--GRLYAIAGYDGNSLLSSIECYDPIIDSWEVV 550
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/175 (29%), Positives = 75/175 (42%), Gaps = 22/175 (12%)
Query: 66 ARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAV- 124
AR VVA IY GG +G +LN + ++D W T TP A + + V
Sbjct: 415 AREGAGLVVA-SGVIYCLGGYDGLNILNSVEKYDPHTGHW----TNVTPMATKRSGAGVA 469
Query: 125 VYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYS 184
+ ++V GG+ G + +S + Y T WT + R GATV
Sbjct: 470 LLNDHIYVVGGFDGTAHLSS-------VEAYNIRTDSWTTVT---SMTTPRCYVGATVLR 519
Query: 185 DKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDK 239
+L+ AGYDGN+ L+ +I D + WE V G C+ V V R+K
Sbjct: 520 GRLYAIAGYDGNSLLS---SIECYDPIIDSWEVVTSMG---TQRCDAGVCVLREK 568
Score = 50.4 bits (119), Expect = 7e-06
Identities = 38/141 (26%), Positives = 66/141 (46%), Gaps = 12/141 (8%)
Query: 667 CDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRY 726
CD+TL ++ PAH+ +LAA S YF AMF S + E G+ + I + S E +L +
Sbjct: 33 CDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAS--TMEILLDF 90
Query: 727 IYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQAL 786
+Y V++ E+ L A ++ C + LE + N L I + A+ +
Sbjct: 91 VYTETVHVTVENVQELLPAACLLQL--KGVKQACCEFLESQLDPSNCLGIRDFAETHNCV 148
Query: 787 DM--------KRHCLHIIVHQ 799
D+ ++H ++ H+
Sbjct: 149 DLMQAAEVFSQKHFPEVVQHE 169
Score = 40.8 bits (94), Expect = 0.005
Identities = 32/124 (25%), Positives = 61/124 (49%), Gaps = 15/124 (12%)
Query: 510 HVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQY 569
+V I+ A E+L+ F+YT+ + HV V + ++ A QL ++Q C ++
Sbjct: 73 YVDIQGLTASTMEILLDFVYTETV------HV-TVENVQELLPAACLLQLKGVKQACCEF 125
Query: 570 IEASVDLQNVLVV---CESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIV 626
+E+ +D N L + E+ + L Q E V + HF +V+ +EF LS +
Sbjct: 126 LESQLDPSNCLGIRDFAETHNCVDLMQAAE-----VFSQKHFPEVVQHEEFILLSQGEVE 180
Query: 627 EIVR 630
++++
Sbjct: 181 KLIK 184
Score = 33.1 bits (74), Expect = 1.1
Identities = 35/179 (19%), Positives = 62/179 (34%), Gaps = 30/179 (16%)
Query: 164 EWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGE 223
EW + R + D++++ GYDG +RL+ + + E W VA
Sbjct: 308 EWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVA---- 363
Query: 224 IPPSCCNFPVAVCR---------DKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLL 274
P+ V R D ++V G G++ ++ +++ W+ +
Sbjct: 364 --------PMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQ-- 413
Query: 275 RGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVG 333
R G +V +Y GG + N + YD W V P + G
Sbjct: 414 -------TAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSG 465
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 64.3 bits (155), Expect = 4e-10
Identities = 71/302 (23%), Positives = 116/302 (38%), Gaps = 35/302 (11%)
Query: 32 HSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTM 91
+S DS+ + + F P W R P + RS+ V +Y GG +G+
Sbjct: 297 NSAGDSLNVVEV-FDPIANC--WERCRP----MTTARSRVGVAVVNGLLYAIGGYDGQLR 349
Query: 92 LNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKND 151
L+ + ++ + +W R G+ + R VV ++V GGY G NS+L +
Sbjct: 350 LSTVEAYNPETDTWTRV---GSMNSKRSAMGTVVLDGQIYVCGGYDG----NSSLSSVET 402
Query: 152 LFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRE 211
Y T +WT + + RSA G TV+ ++++ G+DG L ++ +
Sbjct: 403 ---YSPETDKWT---VVTSMSSNRSAAGVTVFEGRIYVSGGHDG---LQIFSSVEHYNHH 453
Query: 212 LTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTE 271
W A + C A KMFV G G+ + + W I
Sbjct: 454 TATWHPAAG---MLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPM 510
Query: 272 HLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSE 331
H RR ++VA LY GG + + + YD + W + P + E
Sbjct: 511 HT---------RRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHE 561
Query: 332 VG 333
G
Sbjct: 562 GG 563
Score = 49.7 bits (117), Expect = 1e-05
Identities = 56/250 (22%), Positives = 93/250 (37%), Gaps = 33/250 (13%)
Query: 80 IYVFGGDNGK-TMLNDLLRFDVKDCSW--CRAFTTGTPPAPRYHHSAVVYGSSMFVFGGY 136
IY GG N LN + FD W CR TT R V ++ GGY
Sbjct: 290 IYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTA-----RSRVGVAVVNGLLYAIGGY 344
Query: 137 TGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGN 196
G + ++ + Y T WT G + RSA G V ++++ GYDGN
Sbjct: 345 DGQLRLST-------VEAYNPETDTWTR---VGSMNSKRSAMGTVVLDGQIYVCGGYDGN 394
Query: 197 ARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLF 256
+ L+ + T + + T ++ + V V +++V G G +I +++
Sbjct: 395 SSLSSVETYSPETDKWTVVTSMSSNRSAA------GVTVFEGRIYVSGGHDGLQIFSSVE 448
Query: 257 QFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDV 316
+ TW P +L +R H + ++V GG + + Y
Sbjct: 449 HYNHHTATWH--PAAGML-------NKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Query: 317 DFQTWEVVQP 326
W ++ P
Sbjct: 500 VADQWCLIVP 509
Score = 48.1 bits (113), Expect = 3e-05
Identities = 38/157 (24%), Positives = 70/157 (44%), Gaps = 4/157 (2%)
Query: 665 EFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESML 724
+ CD+TL + H AH+ +LAA YF AMF + M E Q I + M PS A E+++
Sbjct: 36 KLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS--ALEALI 93
Query: 725 RYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQ 784
+ Y G + + ++ L + + ++ C L + +N L + + A+
Sbjct: 94 NFAYNGNLAIDQQNVQSLLMGASFLQLQS--IKDACCTFLRERLHPKNCLGVRQFAETMM 151
Query: 785 ALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDII 821
+ I F +VS +L + +L+++
Sbjct: 152 CAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELV 188
Score = 38.5 bits (88), Expect = 0.026
Identities = 45/209 (21%), Positives = 73/209 (34%), Gaps = 31/209 (14%)
Query: 214 CWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHL 273
CWE + + VAV ++ G G + + + + TWTR+ + +
Sbjct: 315 CWERCRP---MTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMN- 370
Query: 274 LRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVV-QPSSDSEV 332
+R V D +YV GG N+ + + Y + W VV SS+
Sbjct: 371 --------SKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSA 422
Query: 333 GGAEVPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPT---QPASELPSGRL 389
G V +E R+ D + T PA+ + + R
Sbjct: 423 AGVTV--------------FEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRC 468
Query: 390 FHAAAVISDAMYIFGGTVDNNIRS-GEMY 417
H AA + M++ GG + S EMY
Sbjct: 469 RHGAASLGSKMFVCGGYDGSGFLSIAEMY 497
>gi|62955044 F-box protein 42 [Homo sapiens]
Length = 717
Score = 62.8 bits (151), Expect = 1e-09
Identities = 61/244 (25%), Positives = 95/244 (38%), Gaps = 21/244 (8%)
Query: 67 RRSKHTVVAY--KDAIYVFGG---DNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHH 121
+R H+ Y ++YVFGG + NDL R D+ W R +G+ P+P+
Sbjct: 118 QRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGA 177
Query: 122 SAVVYGSSMFVFGGYT-GDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGA 180
+ VVY + +FGG+T Y + D + W + P + H +
Sbjct: 178 TLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSS 237
Query: 181 TVYSDKLWIFAGYDGNARL-NDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDK 239
V DK+ +F G G+ ++ ND+W + D E W + SG P V D
Sbjct: 238 CVIDDKMIVFGGSLGSRQMSNDVWVL---DLEQWAWSKPNISGPSPHPRGGQSQIVIDDA 294
Query: 240 MFVFSGQSGAKITNNLFQ------FEFKDKTWTRIPTEHLLRGSPP---PPQRRYGHTMV 290
+ G G N LF+ W + E+ G+P P R G +V
Sbjct: 295 TILILGGCGG--PNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVV 352
Query: 291 AFDR 294
F +
Sbjct: 353 VFSQ 356
Score = 53.9 bits (128), Expect = 6e-07
Identities = 53/213 (24%), Positives = 82/213 (38%), Gaps = 30/213 (14%)
Query: 112 GTPPAPRYHHSAVVY--GSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEG 169
GTP R+ HSA Y SM+VFGG T +S NDL+ + +W G
Sbjct: 113 GTPITQRFSHSACYYDANQSMYVFGGCT----QSSCNAAFNDLWRLDLNSKEWIRPLASG 168
Query: 170 RLPVARSAHGATVYSDKLWIFAG---------YDGNARLNDMWTIGLQDRELTCWEEVAQ 220
P ++ VY D L +F G + +++ T W
Sbjct: 169 SYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKN----WWNCIV 224
Query: 221 SGEIPPSCCNFPVAVCRDKMFVFSGQSGAK-ITNNLFQFEFKDKTWTRIPTEHLLRGSPP 279
+ PP V DKM VF G G++ ++N+++ + + W++ S P
Sbjct: 225 TTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNI------SGP 278
Query: 280 PPQRRYGHTMVAF-DRHLYVFGGAADNTLPNEL 311
P R G + + D + + GG PN L
Sbjct: 279 SPHPRGGQSQIVIDDATILILGGCGG---PNAL 308
>gi|21314675 kelch domain containing 4 [Homo sapiens]
Length = 520
Score = 60.8 bits (146), Expect = 5e-09
Identities = 82/322 (25%), Positives = 128/322 (39%), Gaps = 54/322 (16%)
Query: 58 PPCDEFVGARRSKHTVVAYKDAIYVFGGD--NG-KTML-NDLLRFDVKDCSWCRAFTTGT 113
PP + A S H KD + +FGG+ NG KT L N+L ++ + +W +
Sbjct: 59 PPPSPRLNASLSVHPE---KDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSP 115
Query: 114 PPAPRYHHSAVV--YGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRL 171
PP H + VV G ++VFGG + + DL+ AT W + K G
Sbjct: 116 PPRRCAHQAVVVPQGGGQLWVFGGEFAS-PNGEQFYHYKDLWVLHLATKTWEQVKSTGG- 173
Query: 172 PVARSAHGATVYSDKLWIFAGYDGNAR----LNDMWTIGLQDRELTCWEEVAQS--GEIP 225
P RS H + +L +F G+ + R ND++ L + W +++ S G P
Sbjct: 174 PSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNL---DTFTWSKLSPSGTGPTP 230
Query: 226 PSCCNFPVAVCRDKMFVFSGQSGAKI-------TNNLFQFEFKDK-------TWTRIPTE 271
S C V + + V+ G S ++ T + F K + WTR+
Sbjct: 231 RSGCQMSVTP-QGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPS 289
Query: 272 HLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAAD--------NTLPNELHCYDVDFQTW-- 321
G P P+ + M + L+ FGG D N+L+ YD W
Sbjct: 290 ----GVKPTPRSGFSVAMAPNHQTLF-FGGVCDEEEEESLSGEFFNDLYFYDATRNRWFE 344
Query: 322 -EVVQPSSDSEV---GGAEVPE 339
++ P S+ + G E PE
Sbjct: 345 GQLKGPKSEKKKRRRGRKEEPE 366
Score = 51.2 bits (121), Expect = 4e-06
Identities = 51/215 (23%), Positives = 86/215 (40%), Gaps = 28/215 (13%)
Query: 170 RLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWT-IGLQDRELTCWEEVAQSGEIPPSC 228
RL + S H D+L +F G N + ++ + + + W +V P C
Sbjct: 64 RLNASLSVHPE---KDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRC 120
Query: 229 CNFPVAVCRD--KMFVFSGQSGAKITNNLFQFE------FKDKTWTRIPTEHLLRGSPPP 280
+ V V + +++VF G+ + + ++ KTW ++ S
Sbjct: 121 AHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVK-------STGG 173
Query: 281 PQRRYGHTMVAFDRHLYVFGGAADNTLP----NELHCYDVDFQTWEVVQPSSDSEVGGAE 336
P R GH MVA+ R L +FGG ++T N+++ +++D TW + PS G
Sbjct: 174 PSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPS-----GTGP 228
Query: 337 VPERACASEEVPTLTYEERVGFKKSRDVFGLDFGT 371
P C P G+ K R +D GT
Sbjct: 229 TPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGT 263
Score = 32.3 bits (72), Expect = 1.9
Identities = 32/133 (24%), Positives = 49/133 (36%), Gaps = 18/133 (13%)
Query: 54 WRRLPPCDEFVGARRSKHTVVAYKDAIYVFGG----------DNGKTMLNDLLRFDVKDC 103
W +L P R V + I V+GG D G T +D+ +D
Sbjct: 218 WSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKG-TRHSDMFLLKPEDG 276
Query: 104 S-----WCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNK--NDLFEYK 156
W R +G P PR S + + +F G D +L + NDL+ Y
Sbjct: 277 REDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYD 336
Query: 157 FATGQWTEWKIEG 169
+W E +++G
Sbjct: 337 ATRNRWFEGQLKG 349
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 60.5 bits (145), Expect = 6e-09
Identities = 74/317 (23%), Positives = 117/317 (36%), Gaps = 39/317 (12%)
Query: 53 RWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTG 112
RW + C+E + R+ H K +Y+ GG + N + RFD +W
Sbjct: 317 RWVNVT-CEE--ESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTW---HQVA 370
Query: 113 TPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLP 172
+ R + S V G+ ++ GG+ G + N+ + Y+ T QWT + +
Sbjct: 371 PMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAER-------YEPETNQWT---LIAPMH 420
Query: 173 VARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFP 232
RS AT K++I G++GN L +T + + E W +A +
Sbjct: 421 EQRSDASATTLYGKVYICGGFNGNECL---FTAEVYNTESNQWTVIA---PMRSRRSGIG 474
Query: 233 VAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAF 292
V + ++ G GA + + TW IPT P+ +G +V
Sbjct: 475 VIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMF-------NPRSNFGIEVV-- 525
Query: 293 DRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSE--------VGGAEVPERACAS 344
D L+V GG T + CYD W S G A V E A
Sbjct: 526 DDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARR 585
Query: 345 EEVPTLTYEERVGFKKS 361
+ P L + V + S
Sbjct: 586 DNFPGLALRDEVKYSAS 602
Score = 54.7 bits (130), Expect = 4e-07
Identities = 53/235 (22%), Positives = 92/235 (39%), Gaps = 33/235 (14%)
Query: 36 DSVEYLTLNFGPFETVHR-WRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLND 94
DSV+Y + F+ V + W ++ P + +RR +V + IY GG +G LN
Sbjct: 348 DSVDYFN-SVKRFDPVKKTWHQVAP----MHSRRCYVSVTVLGNFIYAMGGFDGYVRLNT 402
Query: 95 LLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFE 154
R++ + W T AP + + ++++ G +Y LF
Sbjct: 403 AERYEPETNQW-------TLIAPMHEQRSDASATTLY------GKVYICGGFNGNECLFT 449
Query: 155 YKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTC 214
+ + +W + + RS G Y + ++ G+DG RL R
Sbjct: 450 AEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRL----------RSAEA 499
Query: 215 WEEVAQSGEIPPSC----CNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTW 265
+ VA + P+ NF + V D +FV G +G T N+ ++ K W
Sbjct: 500 YSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
Score = 49.3 bits (116), Expect = 1e-05
Identities = 51/245 (20%), Positives = 86/245 (35%), Gaps = 27/245 (11%)
Query: 80 IYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGD 139
++ GG +G + N + +D + W T +PR +H A +++ GG+
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNV--TCEEESPRAYHGAAYLKGYVYIIGGFDSV 350
Query: 140 IYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARL 199
Y NS + F+ T W + R TV + ++ G+DG RL
Sbjct: 351 DYFNSVKR-----FDPVKKT-----WHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRL 400
Query: 200 NDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFE 259
N T + E W +A E + K+++ G +G + +
Sbjct: 401 N---TAERYEPETNQWTLIAPMHE---QRSDASATTLYGKVYICGGFNGNECLFTAEVYN 454
Query: 260 FKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQ 319
+ WT I P RR G ++A+ H+Y GG Y
Sbjct: 455 TESNQWTVIA---------PMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVAN 505
Query: 320 TWEVV 324
TW +
Sbjct: 506 TWRTI 510
Score = 47.8 bits (112), Expect = 4e-05
Identities = 42/165 (25%), Positives = 75/165 (45%), Gaps = 8/165 (4%)
Query: 659 LEGAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQ 718
LEG + CD+ + ++G AHK IL + SSYF A+F S + +I + P
Sbjct: 34 LEG---KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISP--D 88
Query: 719 AFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILE 778
+ ++ Y Y V + P++ L AA + + C + L+ + + N + I +
Sbjct: 89 MMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMG--IVRGCCEFLKSELCLDNCIGICK 146
Query: 779 AADKTQALDMKRHCLHIIVHQFTKVSKLPT-LRSLSQQLLLDIID 822
D ++++ I+H F ++ K+ LS L DII+
Sbjct: 147 FTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIE 191
>gi|46410931 attractin-like 1 [Homo sapiens]
Length = 1379
Score = 59.3 bits (142), Expect = 1e-08
Identities = 71/318 (22%), Positives = 124/318 (38%), Gaps = 44/318 (13%)
Query: 113 TPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLP 172
+P R H AV++G M+V GGYT + YS+ + + Y + W R P
Sbjct: 300 SPSVGRASHKAVLHGKFMWVIGGYTFN-YSSFQM-----VLNYNLESSIWNV-GTPSRGP 352
Query: 173 VARSAHGATVYSDKLWIFAG----YDGNARLNDMWTIGLQDRELTCWEEV----AQSGEI 224
+ R H +Y + ++++ G DGN +++W + + + Q +
Sbjct: 353 LQRYGHSLALYQENIFMYGGRIETNDGNV-TDELWVFNIHSQSWSTKTPTVLGHGQQYAV 411
Query: 225 PPSCCNFPVAVCRD--KMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQ 282
+ RD + +F + T+++ ++ TW T+ + Q
Sbjct: 412 EGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAI------VQ 465
Query: 283 RRYGHTMV--AFDRHLYVFGG-----AADNTLPNELHCYDVDFQTWEVVQPSSDSE---- 331
YGHT V + +YV GG L ++L+ Y+V+ +TW +++ S +
Sbjct: 466 GGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFARYLHS 525
Query: 332 ---VGGAEVPERACASEEVPTLTYEERVGFK-KSRDVFGLDFGTTSAKQPTQPASELPSG 387
+ GA + + G K S D D K +P
Sbjct: 526 AVLINGAMLIFGGNTHNDTSLSN-----GAKCFSADFLAYDIACDEWKILPKPNLHRDVN 580
Query: 388 RLFHAAAVISDAMYIFGG 405
R H+A VI+ +MYIFGG
Sbjct: 581 RFGHSAVVINGSMYIFGG 598
Score = 49.3 bits (116), Expect = 1e-05
Identities = 65/291 (22%), Positives = 112/291 (38%), Gaps = 32/291 (10%)
Query: 173 VARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFP 232
V R++H A ++ +W+ GY N M + + E + W V P
Sbjct: 303 VGRASHKAVLHGKFMWVIGGYTFNYSSFQM--VLNYNLESSIWN-VGTPSRGPLQRYGHS 359
Query: 233 VAVCRDKMFVFSGQ---SGAKITNNLFQFEFKDKTW-TRIPTEHLLRGSPPPPQRRYGHT 288
+A+ ++ +F++ G+ + +T+ L+ F ++W T+ PT L G + H
Sbjct: 360 LALYQENIFMYGGRIETNDGNVTDELWVFNIHSQSWSTKTPTV-LGHGQQYAVEGHSAHI 418
Query: 289 MVAFDRH---LYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASE 345
M R + +FG +A + + Y + TW V + GG +
Sbjct: 419 MELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQGGYG---HTSVYD 475
Query: 346 EVPTLTYEERVGFKK-SRDVFGLDFGTTSAKQPTQPASELPSG---RLFHAAAVISDAMY 401
E+ Y G+K + +GL + T+ + L R H+A +I+ AM
Sbjct: 476 EITKSIYVHG-GYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFARYLHSAVLINGAML 534
Query: 402 IFGGTVDNNIR--------SGEMYRFQFSC-----YPKCTLHEDYGRLWES 439
IFGG N+ S + + +C PK LH D R S
Sbjct: 535 IFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLHRDVNRFGHS 585
Score = 43.9 bits (102), Expect = 6e-04
Identities = 65/315 (20%), Positives = 124/315 (39%), Gaps = 48/315 (15%)
Query: 34 CSDSVEY--LTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDN-GKT 90
C+DS + +LN E+ + P VG R+ H V + ++V GG +
Sbjct: 271 CNDSWQGPDCSLNVPSTESYWILPNVKPFSPSVG--RASHKAVLHGKFMWVIGGYTFNYS 328
Query: 91 MLNDLLRFDVKDCSWCRAFTTGTP---PAPRYHHSAVVYGSSMFVFGG--------YTGD 139
+L ++++ W GTP P RY HS +Y ++F++GG T +
Sbjct: 329 SFQMVLNYNLESSIW----NVGTPSRGPLQRYGHSLALYQENIFMYGGRIETNDGNVTDE 384
Query: 140 IYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARL 199
++ N+ +++ + G ++ +EG SAH + S + + + +A
Sbjct: 385 LWV-FNIHSQSWSTKTPTVLGHGQQYAVEG-----HSAHIMELDSRDVVMIIIFGYSAIY 438
Query: 200 NDMWTIGLQDRELT--CWEEVAQSGEIPPSCCNFPVAV--CRDKMFVFSGQSGAK----- 250
+T +Q+ ++ W G I ++V G
Sbjct: 439 G--YTSSIQEYHISSNTWLVPETKGAIVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYG 496
Query: 251 ITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAA--DNTLP 308
+ ++L+++E KTWT + RY H+ V + + +FGG D +L
Sbjct: 497 LVDDLYKYEVNTKTWTILKESGF---------ARYLHSAVLINGAMLIFGGNTHNDTSLS 547
Query: 309 NELHCYDVDFQTWEV 323
N C+ DF +++
Sbjct: 548 NGAKCFSADFLAYDI 562
Score = 42.0 bits (97), Expect = 0.002
Identities = 56/280 (20%), Positives = 114/280 (40%), Gaps = 55/280 (19%)
Query: 67 RRSKHTVVAYKDAIYVFGG---DNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSA 123
+R H++ Y++ I+++GG N + ++L F++ SW +T TP +
Sbjct: 354 QRYGHSLALYQENIFMYGGRIETNDGNVTDELWVFNIHSQSW----STKTPTVLGHGQQY 409
Query: 124 VVYGSS------------MFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRL 171
V G S M + GY+ S+++ EY ++ W + +G +
Sbjct: 410 AVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQ------EYHISSNTWLVPETKGAI 463
Query: 172 PVARSAHGATVYSD---KLWIFAGYD---GN--ARLNDMWTIGLQDRELTCWEEVAQSGE 223
H +VY + +++ GY GN ++D++ + + T +E +
Sbjct: 464 VQGGYGH-TSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFARY 522
Query: 224 IPPSCCNFPVAVCRDKMFVFSGQS--------GAK-ITNNLFQFEFKDKTWTRIPTEHLL 274
+ + + M +F G + GAK + + ++ W +P +L
Sbjct: 523 LHSA------VLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLH 576
Query: 275 RGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCY 314
R R+GH+ V + +Y+FGG + + L N++ Y
Sbjct: 577 RDV-----NRFGHSAVVINGSMYIFGGFS-SVLLNDILVY 610
Score = 38.5 bits (88), Expect = 0.026
Identities = 32/108 (29%), Positives = 44/108 (40%), Gaps = 30/108 (27%)
Query: 65 GARRSKHTVVAYKDAIYVFGGD--------NG-KTMLNDLLRFDVKDCSWCRAFTTGTPP 115
G R H+ V A+ +FGG+ NG K D L +D+ W P
Sbjct: 518 GFARYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEW------KILP 571
Query: 116 APRYH-------HSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYK 156
P H HSAVV SM++FGG++ + ND+ YK
Sbjct: 572 KPNLHRDVNRFGHSAVVINGSMYIFGGFSSVLL--------NDILVYK 611
Score = 34.7 bits (78), Expect = 0.38
Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 2/92 (2%)
Query: 13 AAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETV-HRWRRLPPCDEFVGARRSKH 71
+A L GA + D S S+ + + +F ++ W+ LP + R H
Sbjct: 525 SAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLHRDVNRFGH 584
Query: 72 TVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDC 103
+ V ++Y+FGG + +LND+L + +C
Sbjct: 585 SAVVINGSMYIFGGFS-SVLLNDILVYKPPNC 615
>gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isoform
a [Homo sapiens]
Length = 534
Score = 58.2 bits (139), Expect = 3e-08
Identities = 40/156 (25%), Positives = 71/156 (45%), Gaps = 4/156 (2%)
Query: 666 FCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLR 725
F D+T+ ++G H+ +L+A+S +F +MF S + E I + ++ S F+ ++
Sbjct: 60 FADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDV--SESVFQLLVD 117
Query: 726 YIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQA 785
YIY+G V + E+ ++ Y L C + L V V N LQ++ AD+
Sbjct: 118 YIYHGTVKLRAEELQEIYEVSDMYQL--TSLFEECSRFLARTVQVGNCLQVMWLADRHSD 175
Query: 786 LDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDII 821
++ H ++ L +LL DII
Sbjct: 176 PELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDII 211
Score = 34.7 bits (78), Expect = 0.38
Identities = 25/122 (20%), Positives = 58/122 (47%), Gaps = 15/122 (12%)
Query: 511 VAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYI 570
+ +++ F++L+ ++Y +K + + ++Y+++ +QL L + C +++
Sbjct: 102 IVLQDVSESVFQLLVDYIYHGTVKLRAEE-------LQEIYEVSDMYQLTSLFEECSRFL 154
Query: 571 EASVDLQNVLVVCESAAR---LQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVE 627
+V + N L V A R +L +HC ++H Q+ +EF L L+ +
Sbjct: 155 ARTVQVGNCLQVMWLADRHSDPELYTAAKHC-----AKTHLAQLQNTEEFLHLPHRLLTD 209
Query: 628 IV 629
I+
Sbjct: 210 II 211
>gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isoform
b [Homo sapiens]
Length = 518
Score = 58.2 bits (139), Expect = 3e-08
Identities = 40/156 (25%), Positives = 71/156 (45%), Gaps = 4/156 (2%)
Query: 666 FCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLR 725
F D+T+ ++G H+ +L+A+S +F +MF S + E I + ++ S F+ ++
Sbjct: 44 FADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDV--SESVFQLLVD 101
Query: 726 YIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQA 785
YIY+G V + E+ ++ Y L C + L V V N LQ++ AD+
Sbjct: 102 YIYHGTVKLRAEELQEIYEVSDMYQL--TSLFEECSRFLARTVQVGNCLQVMWLADRHSD 159
Query: 786 LDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDII 821
++ H ++ L +LL DII
Sbjct: 160 PELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDII 195
Score = 34.7 bits (78), Expect = 0.38
Identities = 25/122 (20%), Positives = 58/122 (47%), Gaps = 15/122 (12%)
Query: 511 VAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYI 570
+ +++ F++L+ ++Y +K + + ++Y+++ +QL L + C +++
Sbjct: 86 IVLQDVSESVFQLLVDYIYHGTVKLRAEE-------LQEIYEVSDMYQLTSLFEECSRFL 138
Query: 571 EASVDLQNVLVVCESAAR---LQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVE 627
+V + N L V A R +L +HC ++H Q+ +EF L L+ +
Sbjct: 139 ARTVQVGNCLQVMWLADRHSDPELYTAAKHC-----AKTHLAQLQNTEEFLHLPHRLLTD 193
Query: 628 IV 629
I+
Sbjct: 194 II 195
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 57.4 bits (137), Expect = 5e-08
Identities = 38/167 (22%), Positives = 77/167 (46%), Gaps = 4/167 (2%)
Query: 666 FCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLR 725
F D +++ P H+ +LAA S +F AMF M E +++I + S +A ++ L
Sbjct: 51 FYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNL--SSKAVKAFLD 108
Query: 726 YIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQA 785
Y Y G+ + ++ F + + L C L ++ + N LQ+L +D +
Sbjct: 109 YAYTGKTKITDDNVEMFFQLSSF--LQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGS 166
Query: 786 LDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQ 832
+ H LH + H F+ + K ++ +L ++S ++ +++
Sbjct: 167 TSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEE 213
Score = 34.7 bits (78), Expect = 0.38
Identities = 26/99 (26%), Positives = 42/99 (42%), Gaps = 14/99 (14%)
Query: 75 AYKDAIYVFGGDNGKTMLNDLLRF-----DVKDCSWCRA------FTTGTPPAPRYHHSA 123
+Y + I++ GG GK L D D +WC F T PR H++
Sbjct: 339 SYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTS 398
Query: 124 VVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQW 162
V+ +FV GG T + ++K+ D+ Y + +W
Sbjct: 399 VMALDRLFVIGGKT---RGSRDIKSLLDVESYNPLSKEW 434
Score = 31.6 bits (70), Expect = 3.2
Identities = 24/107 (22%), Positives = 49/107 (45%), Gaps = 9/107 (8%)
Query: 511 VAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYI 570
V I ++ + + + YT K K + D + M ++L+ Q+ L + C ++
Sbjct: 93 VTITNLSSKAVKAFLDYAYTGKTK------ITDDNVEM-FFQLSSFLQVSFLSKACSDFL 145
Query: 571 EASVDLQNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEF 617
S++L N L + + + L +H L+FV + HF+ + +F
Sbjct: 146 IKSINLVNCLQLLSISDSYGSTSLFDHALHFV--QHHFSLLFKSSDF 190
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 57.4 bits (137), Expect = 5e-08
Identities = 38/167 (22%), Positives = 77/167 (46%), Gaps = 4/167 (2%)
Query: 666 FCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLR 725
F D +++ P H+ +LAA S +F AMF M E +++I + S +A ++ L
Sbjct: 51 FYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNL--SSKAVKAFLD 108
Query: 726 YIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQA 785
Y Y G+ + ++ F + + L C L ++ + N LQ+L +D +
Sbjct: 109 YAYTGKTKITDDNVEMFFQLSSF--LQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGS 166
Query: 786 LDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQ 832
+ H LH + H F+ + K ++ +L ++S ++ +++
Sbjct: 167 TSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEE 213
Score = 34.7 bits (78), Expect = 0.38
Identities = 26/99 (26%), Positives = 42/99 (42%), Gaps = 14/99 (14%)
Query: 75 AYKDAIYVFGGDNGKTMLNDLLRF-----DVKDCSWCRA------FTTGTPPAPRYHHSA 123
+Y + I++ GG GK L D D +WC F T PR H++
Sbjct: 339 SYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTS 398
Query: 124 VVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQW 162
V+ +FV GG T + ++K+ D+ Y + +W
Sbjct: 399 VMALDRLFVIGGKT---RGSRDIKSLLDVESYNPLSKEW 434
Score = 31.6 bits (70), Expect = 3.2
Identities = 24/107 (22%), Positives = 49/107 (45%), Gaps = 9/107 (8%)
Query: 511 VAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYI 570
V I ++ + + + YT K K + D + M ++L+ Q+ L + C ++
Sbjct: 93 VTITNLSSKAVKAFLDYAYTGKTK------ITDDNVEM-FFQLSSFLQVSFLSKACSDFL 145
Query: 571 EASVDLQNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEF 617
S++L N L + + + L +H L+FV + HF+ + +F
Sbjct: 146 IKSINLVNCLQLLSISDSYGSTSLFDHALHFV--QHHFSLLFKSSDF 190
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,676,495
Number of Sequences: 37866
Number of extensions: 1623785
Number of successful extensions: 5137
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 4102
Number of HSP's gapped (non-prelim): 684
length of query: 840
length of database: 18,247,518
effective HSP length: 111
effective length of query: 729
effective length of database: 14,044,392
effective search space: 10238361768
effective search space used: 10238361768
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.