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Search of human proteins with 47607492
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47607492 plectin 1 isoform 1 [Homo sapiens]
(4574 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 8755 0.0
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 8632 0.0
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 8631 0.0
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 8631 0.0
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 8631 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 8630 0.0
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 8630 0.0
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 8630 0.0
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 2363 0.0
gi|33188445 microfilament and actin filament cross-linker protei... 1421 0.0
gi|207452735 epiplakin 1 [Homo sapiens] 1268 0.0
gi|58530842 desmoplakin isoform II [Homo sapiens] 964 0.0
gi|58530840 desmoplakin isoform I [Homo sapiens] 964 0.0
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 921 0.0
gi|221316624 dystonin isoform 4 [Homo sapiens] 861 0.0
gi|221316622 dystonin isoform 3 [Homo sapiens] 861 0.0
gi|221316618 dystonin isoform 2 [Homo sapiens] 861 0.0
gi|34577047 dystonin isoform 1 [Homo sapiens] 861 0.0
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 861 0.0
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 787 0.0
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 430 e-119
gi|45439327 periplakin [Homo sapiens] 413 e-114
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 404 e-111
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 397 e-109
gi|67782321 spectrin beta isoform a [Homo sapiens] 377 e-103
gi|67782319 spectrin beta isoform b [Homo sapiens] 375 e-103
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 357 1e-97
gi|148746195 trichohyalin [Homo sapiens] 352 6e-96
gi|156104874 envoplakin [Homo sapiens] 350 1e-95
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 306 3e-82
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 8755 bits (22718), Expect = 0.0
Identities = 4574/4574 (100%), Positives = 4574/4574 (100%)
Query: 1 MSGEDAEVRAVSEDVSNGSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAV 60
MSGEDAEVRAVSEDVSNGSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAV
Sbjct: 1 MSGEDAEVRAVSEDVSNGSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAV 60
Query: 61 IRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG 120
IRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG
Sbjct: 61 IRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG 120
Query: 121 RMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSG 180
RMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSG
Sbjct: 121 RMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSG 180
Query: 181 QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 240
QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ
Sbjct: 181 QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 240
Query: 241 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 300
TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR
Sbjct: 241 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 300
Query: 301 ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKE 360
ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKE
Sbjct: 301 ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKE 360
Query: 361 ADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLEC 420
ADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLEC
Sbjct: 361 ADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLEC 420
Query: 421 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 480
LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF
Sbjct: 421 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 480
Query: 481 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 540
NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR
Sbjct: 481 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 540
Query: 541 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600
RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE
Sbjct: 541 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600
Query: 601 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660
RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN
Sbjct: 601 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660
Query: 661 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 720
EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV
Sbjct: 661 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 720
Query: 721 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 780
ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR
Sbjct: 721 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 780
Query: 781 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 840
SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC
Sbjct: 781 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVC 840
Query: 841 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 900
DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE
Sbjct: 841 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLE 900
Query: 901 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 960
AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY
Sbjct: 901 AQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 960
Query: 961 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 1020
QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR
Sbjct: 961 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIR 1020
Query: 1021 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1080
LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL
Sbjct: 1021 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1080
Query: 1081 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1140
PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK
Sbjct: 1081 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLK 1140
Query: 1141 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1200
EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE
Sbjct: 1141 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1200
Query: 1201 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260
VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI
Sbjct: 1201 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260
Query: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL
Sbjct: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
Query: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1380
EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1380
Query: 1381 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1440
QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ
Sbjct: 1381 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1440
Query: 1441 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500
QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG
Sbjct: 1441 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500
Query: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1560
ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1560
Query: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
Query: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1680
RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1680
Query: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1860
AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1860
Query: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1920
VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE
Sbjct: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1920
Query: 1921 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS
Sbjct: 1921 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
Query: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
Query: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2220
AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2220
Query: 2221 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2280
QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA
Sbjct: 2221 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2280
Query: 2281 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2340
LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK
Sbjct: 2281 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2340
Query: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
Query: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
Query: 2581 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2640
EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE
Sbjct: 2581 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2640
Query: 2641 EVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2700
EVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA
Sbjct: 2641 EVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2700
Query: 2701 QGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2760
QGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ
Sbjct: 2701 QGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ 2760
Query: 2761 AASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQ 2820
AASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQ
Sbjct: 2761 AASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQ 2820
Query: 2821 KGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGF 2880
KGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGF
Sbjct: 2821 KGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGF 2880
Query: 2881 FDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAP 2940
FDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAP
Sbjct: 2881 FDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAP 2940
Query: 2941 FGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLC 3000
FGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLC
Sbjct: 2941 FGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLC 3000
Query: 3001 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3060
FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE
Sbjct: 3001 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3060
Query: 3061 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3120
AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE
Sbjct: 3061 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3120
Query: 3121 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3180
KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP
Sbjct: 3121 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3180
Query: 3181 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3240
LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS
Sbjct: 3181 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3240
Query: 3241 EKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQ 3300
EKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQ
Sbjct: 3241 EKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQ 3300
Query: 3301 FRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKD 3360
FRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKD
Sbjct: 3301 FRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKD 3360
Query: 3361 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3420
GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA
Sbjct: 3361 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3420
Query: 3421 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3480
ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK
Sbjct: 3421 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3480
Query: 3481 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3540
GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF
Sbjct: 3481 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3540
Query: 3541 DPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQID 3600
DPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQID
Sbjct: 3541 DPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQID 3600
Query: 3601 IPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIR 3660
IPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIR
Sbjct: 3601 IPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIR 3660
Query: 3661 QQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVA 3720
QQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVA
Sbjct: 3661 QQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVA 3720
Query: 3721 GVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLV 3780
GVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLV
Sbjct: 3721 GVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLV 3780
Query: 3781 GPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPR 3840
GPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPR
Sbjct: 3781 GPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPR 3840
Query: 3841 LGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQL 3900
LGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQL
Sbjct: 3841 LGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQL 3900
Query: 3901 LLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTS 3960
LLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTS
Sbjct: 3901 LLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTS 3960
Query: 3961 CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM 4020
CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM
Sbjct: 3961 CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM 4020
Query: 4021 GIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGII 4080
GIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGII
Sbjct: 4021 GIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGII 4080
Query: 4081 DPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQ 4140
DPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQ
Sbjct: 4081 DPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQ 4140
Query: 4141 TGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSE 4200
TGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSE
Sbjct: 4141 TGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSE 4200
Query: 4201 QECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFA 4260
QECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFA
Sbjct: 4201 QECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFA 4260
Query: 4261 DMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVS 4320
DMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVS
Sbjct: 4261 DMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVS 4320
Query: 4321 ITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQ 4380
ITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQ
Sbjct: 4321 ITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQ 4380
Query: 4381 KAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQ 4440
KAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQ
Sbjct: 4381 KAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQ 4440
Query: 4441 RGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKG 4500
RGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKG
Sbjct: 4441 RGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKG 4500
Query: 4501 YYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYAS 4560
YYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYAS
Sbjct: 4501 YYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYAS 4560
Query: 4561 GSSASLGGPESAVA 4574
GSSASLGGPESAVA
Sbjct: 4561 GSSASLGGPESAVA 4574
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 8632 bits (22398), Expect = 0.0
Identities = 4512/4525 (99%), Positives = 4517/4525 (99%), Gaps = 3/4525 (0%)
Query: 53 LDPA---ERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 109
+DP+ + + + DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV
Sbjct: 1 MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
Query: 110 LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 169
LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL
Sbjct: 61 LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
Query: 170 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 229
HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP
Sbjct: 121 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
Query: 230 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 289
LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM
Sbjct: 181 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
Query: 290 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 349
PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL
Sbjct: 241 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
Query: 350 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 409
KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK
Sbjct: 301 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
Query: 410 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 469
QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL
Sbjct: 361 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
Query: 470 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 529
DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ
Sbjct: 421 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 480
Query: 530 VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 589
VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH
Sbjct: 481 VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 540
Query: 590 QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 649
QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV
Sbjct: 541 QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 600
Query: 650 AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 709
AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL
Sbjct: 601 AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 660
Query: 710 LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 769
LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ
Sbjct: 661 LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 720
Query: 770 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 829
EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP
Sbjct: 721 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 780
Query: 830 MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 889
MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN
Sbjct: 781 MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 840
Query: 890 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 949
QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ
Sbjct: 841 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900
Query: 950 RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC 1009
RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC
Sbjct: 901 RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC 960
Query: 1010 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1069
QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR
Sbjct: 961 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1020
Query: 1070 LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE 1129
LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE
Sbjct: 1021 LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE 1080
Query: 1130 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1189
EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER
Sbjct: 1081 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1140
Query: 1190 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1249
LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW
Sbjct: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200
Query: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309
LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
Query: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369
ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
Query: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549
ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
Query: 1550 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1609
AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR
Sbjct: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560
Query: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
Query: 1670 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1729
RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
Query: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1789
GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740
Query: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Query: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909
DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
Query: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 1970 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029
ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980
Query: 2030 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
Query: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2149
QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2100
Query: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2209
EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160
Query: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269
QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220
Query: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329
LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
Query: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 2390 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2449
GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL
Sbjct: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2400
Query: 2450 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2509
ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE
Sbjct: 2401 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2460
Query: 2510 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME
Sbjct: 2461 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Query: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629
QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
Query: 2630 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2689
EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG
Sbjct: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2640
Query: 2690 ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2749
ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS
Sbjct: 2641 ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2700
Query: 2750 PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT 2809
PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT
Sbjct: 2701 PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT 2760
Query: 2810 GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV 2869
GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV
Sbjct: 2761 GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV 2820
Query: 2870 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR 2929
LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR
Sbjct: 2821 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR 2880
Query: 2930 DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV 2989
DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV
Sbjct: 2881 DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV 2940
Query: 2990 VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3049
VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG
Sbjct: 2941 VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3000
Query: 3050 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3109
ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV
Sbjct: 3001 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3060
Query: 3110 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3169
RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG
Sbjct: 3061 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3120
Query: 3170 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3229
IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD
Sbjct: 3121 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3180
Query: 3230 QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF 3289
QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF
Sbjct: 3181 QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF 3240
Query: 3290 TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV 3349
TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV
Sbjct: 3241 TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV 3300
Query: 3350 LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA 3409
LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA
Sbjct: 3301 LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA 3360
Query: 3410 TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG 3469
TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG
Sbjct: 3361 TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG 3420
Query: 3470 STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL 3529
STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL
Sbjct: 3421 STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL 3480
Query: 3530 ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE 3589
ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE
Sbjct: 3481 ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE 3540
Query: 3590 TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII 3649
TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII
Sbjct: 3541 TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII 3600
Query: 3650 IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA 3709
IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA
Sbjct: 3601 IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA 3660
Query: 3710 WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL 3769
WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL
Sbjct: 3661 WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL 3720
Query: 3770 TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA 3829
TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA
Sbjct: 3721 TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA 3780
Query: 3830 QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR 3889
QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR
Sbjct: 3781 QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR 3840
Query: 3890 RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT 3949
RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT
Sbjct: 3841 RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT 3900
Query: 3950 KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 4009
KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG
Sbjct: 3901 KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 3960
Query: 4010 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4069
LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL
Sbjct: 3961 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4020
Query: 4070 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4129
LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL
Sbjct: 4021 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4080
Query: 4130 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL 4189
QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL
Sbjct: 4081 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL 4140
Query: 4190 IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY 4249
IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY
Sbjct: 4141 IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY 4200
Query: 4250 RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG 4309
RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG
Sbjct: 4201 RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG 4260
Query: 4310 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4369
ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD
Sbjct: 4261 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4320
Query: 4370 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4429
KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT
Sbjct: 4321 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4380
Query: 4430 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR 4489
PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR
Sbjct: 4381 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR 4440
Query: 4490 LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY 4549
LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY
Sbjct: 4441 LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY 4500
Query: 4550 SSSGYGRRYASGSSASLGGPESAVA 4574
SSSGYGRRYASGSSASLGGPESAVA
Sbjct: 4501 SSSGYGRRYASGSSASLGGPESAVA 4525
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 8631 bits (22396), Expect = 0.0
Identities = 4510/4512 (99%), Positives = 4511/4512 (99%)
Query: 63 IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 122
+ DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM
Sbjct: 4 VPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 63
Query: 123 RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS 182
RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS
Sbjct: 64 RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS 123
Query: 183 EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTN 242
EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTN
Sbjct: 124 EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTN 183
Query: 243 LENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN 302
LENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN
Sbjct: 184 LENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN 243
Query: 303 ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 362
ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD
Sbjct: 244 ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 303
Query: 363 KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQ 422
KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQ
Sbjct: 304 KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQ 363
Query: 423 RIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 482
RIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFND
Sbjct: 364 RIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 423
Query: 483 VQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRP 542
VQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRP
Sbjct: 424 VQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRP 483
Query: 543 ELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERA 602
ELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERA
Sbjct: 484 ELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERA 543
Query: 603 RSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEK 662
RSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEK
Sbjct: 544 RSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEK 603
Query: 663 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 722
EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES
Sbjct: 604 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 663
Query: 723 FQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA 782
FQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA
Sbjct: 664 FQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA 723
Query: 783 TVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY 842
TVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY
Sbjct: 724 TVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDY 783
Query: 843 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 902
KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ
Sbjct: 784 KQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQ 843
Query: 903 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 962
HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA
Sbjct: 844 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 903
Query: 963 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1022
FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ
Sbjct: 904 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 963
Query: 1023 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082
LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE
Sbjct: 964 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1023
Query: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142
PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA
Sbjct: 1024 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1083
Query: 1143 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202
QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE
Sbjct: 1084 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1143
Query: 1203 RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1262
RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA
Sbjct: 1144 RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1203
Query: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1322
MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP
Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1263
Query: 1323 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR 1382
VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR
Sbjct: 1264 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR 1323
Query: 1383 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1442
AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK
Sbjct: 1324 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1383
Query: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502
RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562
QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503
Query: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622
QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS
Sbjct: 1504 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563
Query: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1682
LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1623
Query: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742
SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683
Query: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802
IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743
Query: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1862
EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803
Query: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922
AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863
Query: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1982
AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923
Query: 1983 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2042
EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1983
Query: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2102
AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV 2043
Query: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162
LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103
Query: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282
EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223
Query: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2342
LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2283
Query: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402
MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343
Query: 2403 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2462
LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2403
Query: 2463 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2522
IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF
Sbjct: 2404 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2463
Query: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Query: 2643 TASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQG 2702
TASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQG
Sbjct: 2584 TASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQG 2643
Query: 2703 HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAA 2762
HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAA
Sbjct: 2644 HTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAA 2703
Query: 2763 SGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKG 2822
SGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKG
Sbjct: 2704 SGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKG 2763
Query: 2823 LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFD 2882
LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFD
Sbjct: 2764 LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFD 2823
Query: 2883 PNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFG 2942
PNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFG
Sbjct: 2824 PNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFG 2883
Query: 2943 KFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE 3002
KFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE
Sbjct: 2884 KFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFE 2943
Query: 3003 GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAG 3062
GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAG
Sbjct: 2944 GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAG 3003
Query: 3063 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3122
QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL
Sbjct: 3004 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3063
Query: 3123 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLD 3182
LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLD
Sbjct: 3064 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLD 3123
Query: 3183 VACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEK 3242
VACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEK
Sbjct: 3124 VACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEK 3183
Query: 3243 AARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFR 3302
AARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFR
Sbjct: 3184 AARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFR 3243
Query: 3303 TGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGK 3362
TGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGK
Sbjct: 3244 TGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGK 3303
Query: 3363 TTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAAT 3422
TTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAAT
Sbjct: 3304 TTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAAT 3363
Query: 3423 GFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGL 3482
GFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGL
Sbjct: 3364 GFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGL 3423
Query: 3483 VLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDP 3542
VLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDP
Sbjct: 3424 VLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDP 3483
Query: 3543 NTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIP 3602
NTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIP
Sbjct: 3484 NTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIP 3543
Query: 3603 GGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQ 3662
GGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQ
Sbjct: 3544 GGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQ 3603
Query: 3663 GLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGV 3722
GLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGV
Sbjct: 3604 GLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGV 3663
Query: 3723 YLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGP 3782
YLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGP
Sbjct: 3664 YLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGP 3723
Query: 3783 ELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLG 3842
ELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLG
Sbjct: 3724 ELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLG 3783
Query: 3843 FHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLL 3902
FHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLL
Sbjct: 3784 FHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLL 3843
Query: 3903 PLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCI 3962
PLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCI
Sbjct: 3844 PLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCI 3903
Query: 3963 AGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGI 4022
AGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGI
Sbjct: 3904 AGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGI 3963
Query: 4023 VGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDP 4082
VGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDP
Sbjct: 3964 VGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDP 4023
Query: 4083 EESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTG 4142
EESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTG
Sbjct: 4024 EESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTG 4083
Query: 4143 LCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQE 4202
LCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQE
Sbjct: 4084 LCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQE 4143
Query: 4203 CEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADM 4262
CEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADM
Sbjct: 4144 CEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADM 4203
Query: 4263 LSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSIT 4322
LSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSIT
Sbjct: 4204 LSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSIT 4263
Query: 4323 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4382
EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA
Sbjct: 4264 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4323
Query: 4383 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4442
FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG
Sbjct: 4324 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4383
Query: 4443 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4502
TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY
Sbjct: 4384 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4443
Query: 4503 SPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGS 4562
SPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGS
Sbjct: 4444 SPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGS 4503
Query: 4563 SASLGGPESAVA 4574
SASLGGPESAVA
Sbjct: 4504 SASLGGPESAVA 4515
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 8631 bits (22396), Expect = 0.0
Identities = 4520/4564 (99%), Positives = 4525/4564 (99%), Gaps = 7/4564 (0%)
Query: 18 GSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIR-------IADERDRV 70
G GSP LP + R + + V +R + R DERDRV
Sbjct: 121 GPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRV 180
Query: 71 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 130
QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV
Sbjct: 181 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 240
Query: 131 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 190
QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK
Sbjct: 241 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 300
Query: 191 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 250
LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF
Sbjct: 301 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 360
Query: 251 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 310
SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE
Sbjct: 361 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 420
Query: 311 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 370
YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY
Sbjct: 421 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 480
Query: 371 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 430
QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM
Sbjct: 481 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 540
Query: 431 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 490
EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR
Sbjct: 541 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 600
Query: 491 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 550
HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR
Sbjct: 601 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 660
Query: 551 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 610
YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS
Sbjct: 661 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 720
Query: 611 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 670
PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD
Sbjct: 721 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 780
Query: 671 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 730
WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ
Sbjct: 781 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 840
Query: 731 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 790
WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL
Sbjct: 841 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 900
Query: 791 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 850
LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH
Sbjct: 901 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 960
Query: 851 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 910
KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW
Sbjct: 961 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 1020
Query: 911 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 970
HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA
Sbjct: 1021 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1080
Query: 971 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1030
GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT
Sbjct: 1081 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1140
Query: 1031 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1090
VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL
Sbjct: 1141 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1200
Query: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1150
RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP
Sbjct: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1260
Query: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320
Query: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA
Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380
Query: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330
VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440
Query: 1331 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1390
KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA
Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1500
Query: 1391 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1450
EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ
Sbjct: 1501 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560
Query: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1510
QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620
Query: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570
EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680
Query: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740
Query: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690
AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800
Query: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750
KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860
Query: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810
QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920
Query: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Query: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100
Query: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050
QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160
Query: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110
LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170
EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280
Query: 2171 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230
QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340
Query: 2231 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290
LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400
Query: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2350
RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460
Query: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410
RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520
Query: 2411 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470
RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH
Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580
Query: 2471 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530
DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL
Sbjct: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640
Query: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590
QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700
Query: 2591 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650
EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT
Sbjct: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760
Query: 2651 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2710
KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA
Sbjct: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2820
Query: 2711 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV 2770
RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV
Sbjct: 2821 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV 2880
Query: 2771 RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2830
RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI
Sbjct: 2881 RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2940
Query: 2831 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2890
RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT
Sbjct: 2941 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 3000
Query: 2891 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2950
YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT
Sbjct: 3001 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 3060
Query: 2951 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3010
IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA
Sbjct: 3061 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3120
Query: 3011 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3070
AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA
Sbjct: 3121 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3180
Query: 3071 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3130
LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT
Sbjct: 3181 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3240
Query: 3131 GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL 3190
GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL
Sbjct: 3241 GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL 3300
Query: 3191 DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE 3250
DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE
Sbjct: 3301 DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE 3360
Query: 3251 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK 3310
LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK
Sbjct: 3361 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK 3420
Query: 3311 VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE 3370
VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE
Sbjct: 3421 VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE 3480
Query: 3371 LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3430
LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR
Sbjct: 3481 LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3540
Query: 3431 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3490
NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR
Sbjct: 3541 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3600
Query: 3491 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3550
LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY
Sbjct: 3601 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3660
Query: 3551 RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS 3610
RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS
Sbjct: 3661 RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS 3720
Query: 3611 TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV 3670
TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV
Sbjct: 3721 TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV 3780
Query: 3671 RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT 3730
RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT
Sbjct: 3781 RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT 3840
Query: 3731 LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS 3790
LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS
Sbjct: 3841 LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS 3900
Query: 3791 AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA 3850
AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA
Sbjct: 3901 AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA 3960
Query: 3851 YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL 3910
YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL
Sbjct: 3961 YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL 4020
Query: 3911 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3970
TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT
Sbjct: 4021 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 4080
Query: 3971 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4030
KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK
Sbjct: 4081 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4140
Query: 4031 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4090
LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV
Sbjct: 4141 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4200
Query: 4091 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE 4150
EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE
Sbjct: 4201 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE 4260
Query: 4151 KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI 4210
KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI
Sbjct: 4261 KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI 4320
Query: 4211 SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF 4270
SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF
Sbjct: 4321 SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF 4380
Query: 4271 RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV 4330
RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV
Sbjct: 4381 RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV 4440
Query: 4331 DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR 4390
DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR
Sbjct: 4441 DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR 4500
Query: 4391 TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ 4450
TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ
Sbjct: 4501 TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ 4560
Query: 4451 KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS 4510
KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS
Sbjct: 4561 KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS 4620
Query: 4511 GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE 4570
GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE
Sbjct: 4621 GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE 4680
Query: 4571 SAVA 4574
SAVA
Sbjct: 4681 SAVA 4684
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 8631 bits (22395), Expect = 0.0
Identities = 4513/4525 (99%), Positives = 4515/4525 (99%), Gaps = 4/4525 (0%)
Query: 54 DPAERAVIR----IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 109
+PA R + DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV
Sbjct: 27 EPARRGYLYQQLCCVDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 86
Query: 110 LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 169
LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL
Sbjct: 87 LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 146
Query: 170 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 229
HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP
Sbjct: 147 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 206
Query: 230 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 289
LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM
Sbjct: 207 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 266
Query: 290 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 349
PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL
Sbjct: 267 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 326
Query: 350 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 409
KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK
Sbjct: 327 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 386
Query: 410 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 469
QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL
Sbjct: 387 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 446
Query: 470 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 529
DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ
Sbjct: 447 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 506
Query: 530 VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 589
VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH
Sbjct: 507 VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 566
Query: 590 QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 649
QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV
Sbjct: 567 QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 626
Query: 650 AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 709
AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL
Sbjct: 627 AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 686
Query: 710 LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 769
LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ
Sbjct: 687 LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 746
Query: 770 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 829
EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP
Sbjct: 747 EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 806
Query: 830 MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 889
MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN
Sbjct: 807 MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 866
Query: 890 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 949
QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ
Sbjct: 867 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 926
Query: 950 RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC 1009
RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC
Sbjct: 927 RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC 986
Query: 1010 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1069
QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR
Sbjct: 987 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1046
Query: 1070 LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE 1129
LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE
Sbjct: 1047 LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE 1106
Query: 1130 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1189
EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER
Sbjct: 1107 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1166
Query: 1190 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1249
LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW
Sbjct: 1167 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1226
Query: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309
LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286
Query: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369
ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346
Query: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549
ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526
Query: 1550 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1609
AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR
Sbjct: 1527 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1586
Query: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669
ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
Query: 1670 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1729
RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE
Sbjct: 1647 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1706
Query: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1789
GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA
Sbjct: 1707 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1766
Query: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909
DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886
Query: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 1970 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029
ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR
Sbjct: 1947 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2006
Query: 2030 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE
Sbjct: 2007 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066
Query: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2149
QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2126
Query: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2209
EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186
Query: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269
QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2246
Query: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329
LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306
Query: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 2390 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2449
GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL
Sbjct: 2367 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2426
Query: 2450 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2509
ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE
Sbjct: 2427 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2486
Query: 2510 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME
Sbjct: 2487 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Query: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629
QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606
Query: 2630 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2689
EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG
Sbjct: 2607 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2666
Query: 2690 ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2749
ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS
Sbjct: 2667 ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2726
Query: 2750 PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT 2809
PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT
Sbjct: 2727 PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT 2786
Query: 2810 GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV 2869
GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV
Sbjct: 2787 GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV 2846
Query: 2870 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR 2929
LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR
Sbjct: 2847 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR 2906
Query: 2930 DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV 2989
DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV
Sbjct: 2907 DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV 2966
Query: 2990 VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3049
VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG
Sbjct: 2967 VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3026
Query: 3050 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3109
ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV
Sbjct: 3027 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3086
Query: 3110 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3169
RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG
Sbjct: 3087 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3146
Query: 3170 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3229
IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD
Sbjct: 3147 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3206
Query: 3230 QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF 3289
QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF
Sbjct: 3207 QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF 3266
Query: 3290 TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV 3349
TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV
Sbjct: 3267 TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV 3326
Query: 3350 LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA 3409
LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA
Sbjct: 3327 LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA 3386
Query: 3410 TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG 3469
TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG
Sbjct: 3387 TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG 3446
Query: 3470 STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL 3529
STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL
Sbjct: 3447 STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL 3506
Query: 3530 ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE 3589
ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE
Sbjct: 3507 ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE 3566
Query: 3590 TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII 3649
TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII
Sbjct: 3567 TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII 3626
Query: 3650 IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA 3709
IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA
Sbjct: 3627 IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA 3686
Query: 3710 WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL 3769
WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL
Sbjct: 3687 WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL 3746
Query: 3770 TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA 3829
TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA
Sbjct: 3747 TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA 3806
Query: 3830 QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR 3889
QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR
Sbjct: 3807 QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR 3866
Query: 3890 RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT 3949
RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT
Sbjct: 3867 RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT 3926
Query: 3950 KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 4009
KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG
Sbjct: 3927 KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 3986
Query: 4010 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4069
LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL
Sbjct: 3987 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4046
Query: 4070 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4129
LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL
Sbjct: 4047 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4106
Query: 4130 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL 4189
QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL
Sbjct: 4107 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL 4166
Query: 4190 IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY 4249
IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY
Sbjct: 4167 IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY 4226
Query: 4250 RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG 4309
RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG
Sbjct: 4227 RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG 4286
Query: 4310 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4369
ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD
Sbjct: 4287 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4346
Query: 4370 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4429
KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT
Sbjct: 4347 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4406
Query: 4430 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR 4489
PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR
Sbjct: 4407 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR 4466
Query: 4490 LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY 4549
LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY
Sbjct: 4467 LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY 4526
Query: 4550 SSSGYGRRYASGSSASLGGPESAVA 4574
SSSGYGRRYASGSSASLGGPESAVA
Sbjct: 4527 SSSGYGRRYASGSSASLGGPESAVA 4551
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 8630 bits (22394), Expect = 0.0
Identities = 4510/4510 (100%), Positives = 4510/4510 (100%)
Query: 65 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 124
DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 97
Query: 125 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 184
HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 98 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 157
Query: 185 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 244
MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 158 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 217
Query: 245 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 304
NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 218 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 277
Query: 305 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 364
QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 278 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337
Query: 365 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 424
RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 338 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 397
Query: 425 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 484
VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 398 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457
Query: 485 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 544
TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 517
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS
Sbjct: 518 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 578 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV
Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ
Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 998 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1384
SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444
ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1684
EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 1685 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1744
AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 1745 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1804
LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864
SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 1865 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924
KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984
LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104
VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 2165 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2284
TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2344
DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 2345 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404
AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377
Query: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464
MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437
Query: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524
RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 2525 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644
RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 2645 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704
SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 2705 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2764
TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2737
Query: 2765 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2824
FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI
Sbjct: 2738 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2797
Query: 2825 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2884
VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN
Sbjct: 2798 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2857
Query: 2885 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2944
THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF
Sbjct: 2858 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2917
Query: 2945 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3004
QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL
Sbjct: 2918 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2977
Query: 3005 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3064
RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK
Sbjct: 2978 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3037
Query: 3065 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3124
LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS
Sbjct: 3038 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3097
Query: 3125 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3184
AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA
Sbjct: 3098 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3157
Query: 3185 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3244
CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA
Sbjct: 3158 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3217
Query: 3245 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3304
RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG
Sbjct: 3218 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3277
Query: 3305 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3364
KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT
Sbjct: 3278 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3337
Query: 3365 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3424
VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF
Sbjct: 3338 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3397
Query: 3425 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3484
LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL
Sbjct: 3398 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3457
Query: 3485 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3544
RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT
Sbjct: 3458 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3517
Query: 3545 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3604
HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG
Sbjct: 3518 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3577
Query: 3605 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3664
GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL
Sbjct: 3578 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3637
Query: 3665 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3724
ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL
Sbjct: 3638 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3697
Query: 3725 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3784
PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL
Sbjct: 3698 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3757
Query: 3785 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3844
HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH
Sbjct: 3758 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3817
Query: 3845 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3904
LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL
Sbjct: 3818 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3877
Query: 3905 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3964
SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG
Sbjct: 3878 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3937
Query: 3965 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4024
VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG
Sbjct: 3938 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3997
Query: 4025 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4084
PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE
Sbjct: 3998 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4057
Query: 4085 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4144
SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC
Sbjct: 4058 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4117
Query: 4145 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4204
LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE
Sbjct: 4118 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4177
Query: 4205 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4264
WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS
Sbjct: 4178 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4237
Query: 4265 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4324
GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA
Sbjct: 4238 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4297
Query: 4325 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4384
MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC
Sbjct: 4298 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4357
Query: 4385 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4444
GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV
Sbjct: 4358 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4417
Query: 4445 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4504
DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP
Sbjct: 4418 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4477
Query: 4505 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4564
YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA
Sbjct: 4478 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4537
Query: 4565 SLGGPESAVA 4574
SLGGPESAVA
Sbjct: 4538 SLGGPESAVA 4547
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 8630 bits (22394), Expect = 0.0
Identities = 4510/4510 (100%), Positives = 4510/4510 (100%)
Query: 65 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 124
DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 97
Query: 125 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 184
HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 98 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 157
Query: 185 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 244
MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 158 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 217
Query: 245 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 304
NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 218 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 277
Query: 305 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 364
QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 278 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337
Query: 365 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 424
RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 338 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 397
Query: 425 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 484
VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 398 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457
Query: 485 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 544
TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 517
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS
Sbjct: 518 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 578 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV
Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ
Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 998 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1384
SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444
ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417
Query: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA
Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1684
EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 1685 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1744
AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 1745 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1804
LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864
SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 1865 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924
KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984
LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104
VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 2165 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2284
TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2344
DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 2345 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404
AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377
Query: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464
MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437
Query: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524
RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 2525 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644
RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 2645 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704
SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 2705 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2764
TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2737
Query: 2765 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2824
FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI
Sbjct: 2738 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2797
Query: 2825 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2884
VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN
Sbjct: 2798 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2857
Query: 2885 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2944
THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF
Sbjct: 2858 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2917
Query: 2945 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3004
QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL
Sbjct: 2918 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2977
Query: 3005 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3064
RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK
Sbjct: 2978 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3037
Query: 3065 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3124
LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS
Sbjct: 3038 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3097
Query: 3125 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3184
AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA
Sbjct: 3098 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3157
Query: 3185 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3244
CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA
Sbjct: 3158 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3217
Query: 3245 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3304
RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG
Sbjct: 3218 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3277
Query: 3305 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3364
KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT
Sbjct: 3278 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3337
Query: 3365 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3424
VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF
Sbjct: 3338 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3397
Query: 3425 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3484
LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL
Sbjct: 3398 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3457
Query: 3485 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3544
RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT
Sbjct: 3458 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3517
Query: 3545 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3604
HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG
Sbjct: 3518 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3577
Query: 3605 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3664
GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL
Sbjct: 3578 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3637
Query: 3665 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3724
ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL
Sbjct: 3638 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3697
Query: 3725 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3784
PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL
Sbjct: 3698 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3757
Query: 3785 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3844
HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH
Sbjct: 3758 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3817
Query: 3845 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3904
LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL
Sbjct: 3818 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3877
Query: 3905 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3964
SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG
Sbjct: 3878 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3937
Query: 3965 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4024
VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG
Sbjct: 3938 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3997
Query: 4025 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4084
PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE
Sbjct: 3998 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4057
Query: 4085 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4144
SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC
Sbjct: 4058 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4117
Query: 4145 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4204
LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE
Sbjct: 4118 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4177
Query: 4205 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4264
WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS
Sbjct: 4178 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4237
Query: 4265 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4324
GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA
Sbjct: 4238 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4297
Query: 4325 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4384
MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC
Sbjct: 4298 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4357
Query: 4385 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4444
GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV
Sbjct: 4358 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4417
Query: 4445 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4504
DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP
Sbjct: 4418 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4477
Query: 4505 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4564
YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA
Sbjct: 4478 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4537
Query: 4565 SLGGPESAVA 4574
SLGGPESAVA
Sbjct: 4538 SLGGPESAVA 4547
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 8630 bits (22394), Expect = 0.0
Identities = 4510/4510 (100%), Positives = 4510/4510 (100%)
Query: 65 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 124
DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 24 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 83
Query: 125 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 184
HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 84 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 143
Query: 185 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 244
MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 144 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 203
Query: 245 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 304
NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 204 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 263
Query: 305 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 364
QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 264 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 323
Query: 365 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 424
RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 324 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 383
Query: 425 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 484
VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 384 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 443
Query: 485 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 544
TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 444 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 503
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS
Sbjct: 504 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 564 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 623
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 624 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV
Sbjct: 684 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 744 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ
Sbjct: 804 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 864 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 924 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 983
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 984 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1044 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283
Query: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1384
SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1343
Query: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444
ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1403
Query: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA
Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523
Query: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583
Query: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1684
EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL
Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1643
Query: 1685 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1744
AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR
Sbjct: 1644 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1703
Query: 1745 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1804
LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE
Sbjct: 1704 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1763
Query: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864
SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1823
Query: 1865 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1924
KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ
Sbjct: 1824 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883
Query: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984
LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943
Query: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003
Query: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104
VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2063
Query: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 2165 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183
Query: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2284
TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2243
Query: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2344
DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2303
Query: 2345 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404
AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE
Sbjct: 2304 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363
Query: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464
MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2423
Query: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524
RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2483
Query: 2525 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR
Sbjct: 2484 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543
Query: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644
RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603
Query: 2645 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704
SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT
Sbjct: 2604 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663
Query: 2705 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2764
TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG
Sbjct: 2664 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2723
Query: 2765 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2824
FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI
Sbjct: 2724 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2783
Query: 2825 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2884
VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN
Sbjct: 2784 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2843
Query: 2885 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2944
THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF
Sbjct: 2844 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2903
Query: 2945 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3004
QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL
Sbjct: 2904 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2963
Query: 3005 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3064
RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK
Sbjct: 2964 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3023
Query: 3065 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3124
LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS
Sbjct: 3024 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3083
Query: 3125 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3184
AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA
Sbjct: 3084 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3143
Query: 3185 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3244
CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA
Sbjct: 3144 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3203
Query: 3245 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3304
RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG
Sbjct: 3204 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3263
Query: 3305 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3364
KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT
Sbjct: 3264 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3323
Query: 3365 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3424
VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF
Sbjct: 3324 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3383
Query: 3425 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3484
LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL
Sbjct: 3384 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3443
Query: 3485 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3544
RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT
Sbjct: 3444 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3503
Query: 3545 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3604
HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG
Sbjct: 3504 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3563
Query: 3605 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3664
GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL
Sbjct: 3564 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3623
Query: 3665 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3724
ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL
Sbjct: 3624 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3683
Query: 3725 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3784
PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL
Sbjct: 3684 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3743
Query: 3785 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3844
HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH
Sbjct: 3744 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3803
Query: 3845 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3904
LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL
Sbjct: 3804 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3863
Query: 3905 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3964
SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG
Sbjct: 3864 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3923
Query: 3965 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4024
VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG
Sbjct: 3924 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3983
Query: 4025 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4084
PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE
Sbjct: 3984 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4043
Query: 4085 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4144
SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC
Sbjct: 4044 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4103
Query: 4145 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4204
LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE
Sbjct: 4104 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4163
Query: 4205 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4264
WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS
Sbjct: 4164 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4223
Query: 4265 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4324
GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA
Sbjct: 4224 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4283
Query: 4325 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4384
MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC
Sbjct: 4284 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4343
Query: 4385 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4444
GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV
Sbjct: 4344 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4403
Query: 4445 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4504
DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP
Sbjct: 4404 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4463
Query: 4505 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4564
YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA
Sbjct: 4464 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4523
Query: 4565 SLGGPESAVA 4574
SLGGPESAVA
Sbjct: 4524 SLGGPESAVA 4533
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
Length = 1369
Score = 2363 bits (6125), Expect = 0.0
Identities = 1203/1253 (96%), Positives = 1211/1253 (96%), Gaps = 7/1253 (0%)
Query: 18 GSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIR-------IADERDRV 70
G GSP LP + R + + V +R + R DERDRV
Sbjct: 117 GPLGSPPKRGPLPTEEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRV 176
Query: 71 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 130
QKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV
Sbjct: 177 QKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 236
Query: 131 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 190
QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK
Sbjct: 237 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 296
Query: 191 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 250
LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF
Sbjct: 297 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 356
Query: 251 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 310
SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE
Sbjct: 357 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 416
Query: 311 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 370
YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY
Sbjct: 417 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 476
Query: 371 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 430
QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM
Sbjct: 477 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 536
Query: 431 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 490
EAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR
Sbjct: 537 EAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 596
Query: 491 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 550
HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR
Sbjct: 597 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 656
Query: 551 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 610
YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARSDEGQLS
Sbjct: 657 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLS 716
Query: 611 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 670
PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD
Sbjct: 717 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 776
Query: 671 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 730
WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ
Sbjct: 777 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 836
Query: 731 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 790
WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATVTRLEDL
Sbjct: 837 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDL 896
Query: 791 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 850
LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH
Sbjct: 897 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 956
Query: 851 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 910
KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQALVTLW
Sbjct: 957 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLW 1016
Query: 911 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 970
HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA
Sbjct: 1017 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1076
Query: 971 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1030
GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT
Sbjct: 1077 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1136
Query: 1031 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1090
VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL
Sbjct: 1137 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1196
Query: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1150
RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP
Sbjct: 1197 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1256
Query: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ
Sbjct: 1257 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1316
Query: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263
LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1317 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
Score = 69.7 bits (169), Expect = 6e-11
Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)
Query: 1549 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1600
++E A+EK QR ++ + LR + + RL A + R + + + + R
Sbjct: 287 QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
Query: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660
E + S AE+ + R L E V V Q E++ R ++
Sbjct: 347 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
Query: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1712
++ANE L+LR Q ++ L + + A E R EE + +
Sbjct: 404 -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
Query: 1713 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766
+ EL +E +K R Q EG Q +L L E E G+ +LE E
Sbjct: 459 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
Query: 1767 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826
+ R+E E ++ +L+ EAG E
Sbjct: 515 ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
Query: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1886
+A L L + R LA ++ E ER L K ++ I L
Sbjct: 545 LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
Query: 1887 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1936
+ + + R + E RR RL E+ + + RL Q+ + + ++R+
Sbjct: 588 DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
Query: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1994
L + TLR + + + + + A G +E +LG R + + QA++
Sbjct: 648 PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
Query: 1995 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2051
E AR + QL+ R+ R+ A +++ R +LE + + A +E L
Sbjct: 706 ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
Query: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2110
E+ E+E + + + + K +++ +E EL++ +++ Q+ D+L E
Sbjct: 766 NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
Query: 2111 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2153
AR E + EA ++ Q V EAE Q +E +
Sbjct: 820 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
Query: 2154 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2213
+ +A R E + + AQ E+ L + + + + K K Q L+ +
Sbjct: 880 RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
Query: 2214 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2264
L L Q+E T H+ + L Q + ++ + V F V
Sbjct: 936 MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
Query: 2265 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2321
+E+ + R+EA+++AL+ + Q + +A ++ R V + A R
Sbjct: 996 QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
Query: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2365
L E+ Q E + ++ Q+A RL AE E LLQ ++
Sbjct: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
Query: 2366 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2419
AQE++R Q+ E + + LEA R +L + E A R+AE
Sbjct: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
Query: 2420 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2476
+AQA E + R +AE++ LA E TL
Sbjct: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
Query: 2477 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2535
+ELE KL+Q L + E+++T+ +++ TQ ++ + ++ L + +
Sbjct: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
Query: 2536 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2585
+E KA L++L A+AQQ LR+E + Q+ E+ +QR E R
Sbjct: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
Query: 2586 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2613
+ + + R Q L Q + ++R+ E+L
Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
Score = 67.0 bits (162), Expect = 4e-10
Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)
Query: 1554 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607
AA E++R + EE+ L+ +E E ++A+ R++ + +LE A ++ + ++
Sbjct: 433 AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
Query: 1608 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667
+E+ + HVA+ ER Q ++E ER L+ +
Sbjct: 493 -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
Query: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1723
+ +LQ E ++ L QA+A Q + A + +R G+ E + +
Sbjct: 529 RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
Query: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1783
+ L +G Q + + RL E+ + E RL+ AA + ++ +
Sbjct: 589 VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
Query: 1784 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1831
+ R E+E S R ++ + E+++ R+ EA+ G R L +
Sbjct: 643 SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
Query: 1832 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
+A E A+ QL+ R R+ + +L ++ L+ E+ +
Sbjct: 700 EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
Query: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
+ ++ + + EE+ +D + +K S S L R+ L E +++ +
Sbjct: 753 SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
Query: 1951 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1998
+ +L SF+ A + L+L ++ NA + E E
Sbjct: 812 GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
Query: 1999 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2055
Q+ +E RR+ + +R E+ + A+ K L E + L + A+ + +
Sbjct: 872 QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
Query: 2056 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113
+ A ++ L A Q E H K E Q + S L A
Sbjct: 929 PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
Query: 2114 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2157
+ +E +EA R++A+ +A + + V+ L QS Q R+
Sbjct: 983 AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
Query: 2158 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2202
+ A L+ E +++A + QA LR Q A + + AE
Sbjct: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
Query: 2203 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2254
Q+L Q AQ E EL +RLQLE + + + RL+ E AR+ +Q
Sbjct: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
Query: 2255 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2313
E + ++E L K AR+ AE + L L + L+ E E E+ LS
Sbjct: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
Query: 2314 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2373
E + L + + AE++L+ + ++EA + A L+ K + ++ R
Sbjct: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
Query: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2431
E ++ L +E +G Q E +QR E E ER + RVA+ + R QA A+ D +
Sbjct: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
Query: 2432 RFRKQAEEIGEKL 2444
+++ E++G +L
Sbjct: 1332 --QRELEQLGRQL 1342
Score = 62.0 bits (149), Expect = 1e-08
Identities = 164/754 (21%), Positives = 286/754 (37%), Gaps = 154/754 (20%)
Query: 1218 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1277
V Q+ R+ ELE LRY ++ L AW+++ + R + + D +V QL
Sbjct: 639 VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
Query: 1278 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1325
+ L + IE K+E + Q A + Y L + KA+L + S
Sbjct: 691 HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
Query: 1326 PAKKPKVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQ 1380
V + ++ ++ +E ++ +S+ T + + S +R +E +E+++ E
Sbjct: 751 --LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKEL 808
Query: 1381 QRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------QAE 1414
Q A +R + +AAL+ Q QL EAH + A +AE
Sbjct: 809 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 868
Query: 1415 REAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAK 1463
+ ++LQ+ ++ + V R E+ DAQ +K + E L L + ++A +Q K
Sbjct: 869 GQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
Query: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK-- 1516
R R RL + ++++ + G Q L + EA
Sbjct: 929 PRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVC 988
Query: 1517 -------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569
++ QE RL Q Q Q V++ S + A + +R +Q +
Sbjct: 989 FLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----AWQSLRRDVQLIRSWS 1043
Query: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629
L R + E RQ +LE ++ + Q E ER
Sbjct: 1044 LAT------FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1097
Query: 1630 VAQLREEAERRAQQQAEAERAREEAER---ELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686
QL + E+ AQ+++ +R E + +LE + + LRL L E + AQ
Sbjct: 1098 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA---RECAQ 1154
Query: 1687 AEAEKQKEEAEREARRRG----KAEEQAV--------------RQRELAEQELEKQRQLA 1728
AE+QK +AE E +G AE + V + EL +LE+ R L+
Sbjct: 1155 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1214
Query: 1729 --------------EGT--AQQRLAAEQE---------------------LIRLRAETEQ 1751
GT A++ L A +E L +LRA+ E
Sbjct: 1215 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1274
Query: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1811
+ L +EL Q Q+ E + E+ + R + LL + + ++
Sbjct: 1275 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDV 1330
Query: 1812 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845
++ LE + R E A L A ++A+R+++
Sbjct: 1331 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
Score = 60.8 bits (146), Expect = 3e-08
Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)
Query: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1117
GL + + A+ E+ A + +P R LG+L+ ++ + S L L++
Sbjct: 693 GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
Query: 1118 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1176
+ S V T+ + EE++ + T + A K S L + E ++
Sbjct: 751 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
Query: 1177 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1236
+++ Q G+RL + VE ++ A L +W +L + L++
Sbjct: 804 --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
Query: 1237 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1286
+++ + + G LQ+A RR+ L D+Q +EQL + + L +
Sbjct: 859 QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
Query: 1287 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1334
+ + V + + + + A+ DY ++++ +K + PA+ K S
Sbjct: 919 KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
Query: 1335 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389
GSE+ + L + +T L +Q+ ++ + + + L Q +L
Sbjct: 979 GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
Query: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449
+ + E QA E + + Q+ E + A+++ S
Sbjct: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
Query: 1450 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1509
QQL QS E Q ++R R E++ +RLQLEA E + + LR
Sbjct: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
Query: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1565
+ K A+E A+R+ Q +K QAEVE + A A EK AL A
Sbjct: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
Query: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625
LR + E +L Q ++S A + EK + ++
Sbjct: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
Query: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1684
A LR E+ + QA E L+A +A +L+A+ AQQ +
Sbjct: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
Query: 1685 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1742
+ E +E ER +R G+ + + R RE Q LE+ Q LA+ +QR
Sbjct: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
Query: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782
E EQ +Q + E L A +++++++A
Sbjct: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 1421 bits (3679), Expect = 0.0
Identities = 947/2837 (33%), Positives = 1513/2837 (53%), Gaps = 251/2837 (8%)
Query: 17 NGSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQKKTFT 76
+GS PGDTLPWNL ++ +R S SVLDPAERAV+R+ADERDRVQKKTFT
Sbjct: 31 SGSLSPCPPGDTLPWNLPLHEQKKRK-----SQDSVLDPAERAVVRVADERDRVQKKTFT 85
Query: 77 KWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDY 136
KWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG LPREKGRMRFH+LQNVQIALD+
Sbjct: 86 KWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDF 145
Query: 137 LRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQ 196
L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S DM+AKEKLLLW+Q
Sbjct: 146 LKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQ 205
Query: 197 RMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERD 256
++ GY G++C NF+S W DG++FNA+IHR++P L+DM +V Q+N ENL+QAF VAER
Sbjct: 206 KVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER- 264
Query: 257 LGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVL 316
LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+ +G+ A E+ RWQEY+ V
Sbjct: 265 LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVD 324
Query: 317 LLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGA 376
L+ W++ HT ++ FP + E++ L++Q++ FKE E+ AKE +K R + +Y+ LE
Sbjct: 325 SLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVW 384
Query: 377 VQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCE 436
++ G++K+P GYHP DVE+EWGKL + +LEREK LR ERLE L +I K+Q A CE
Sbjct: 385 IEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCE 444
Query: 437 EQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQ 496
E+L A LQ+D L +G+ Q +V + + + +IR L D+Q L+D + Q E+
Sbjct: 445 EKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEE 504
Query: 497 MYRRVYRLHERLVAIRTEYNLRLKAG------------------VAAPATQVAQVTLQSV 538
+ RV RL + LV +R E + G A P T+ + S
Sbjct: 505 LAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSW 564
Query: 539 QRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 587
R+P EL ++ LR++ +LL+WVEE Q +++ AEWG DLPSVE QL + +
Sbjct: 565 FRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQH 624
Query: 588 LHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647
+H S+EE + ++ AR EG++S +Y + LG+L+ QY KL +S R+R L+SLH
Sbjct: 625 IHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHK 684
Query: 648 FVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGD 707
FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+ +S L ELE K+ + LQ+ +
Sbjct: 685 FVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAE 744
Query: 708 RLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQK 767
L E+HPA+ TVE++ AA+Q+Q WM QLC C+E H+KEN AYFQFFSD RE E L+
Sbjct: 745 LLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRN 804
Query: 768 LQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPA 827
LQ++++RKYSCD + +++RLEDLLQD+ DEKEQL + K ++ L R+K +VQLKPR P
Sbjct: 805 LQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPD 864
Query: 828 HPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPP 887
H ++ + + AVCDY+Q+E+T+ K DEC L +Q + WKV+S +G+EA VPSVCFL+PP
Sbjct: 865 HVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPP 924
Query: 888 PNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPE 947
PN++A E +R+E +Q ++ LWHQLHV+ KSL++W LR+D+ L+++W+L R+ P
Sbjct: 925 PNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPG 984
Query: 948 EQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 1007
E Q + +L+ HY+ FL+DS+D+ F DRL E E +C +Q L++S+E +EE+
Sbjct: 985 ECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEET 1044
Query: 1008 RCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQKAQAEVEGL 1063
+ ISELK+IRL+LE E R V R++ D++ ++ A RIAEQ+ Q +++ L
Sbjct: 1045 VAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQL 1104
Query: 1064 GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIR 1123
+ +S + + L S + PTLRSEL L + K++ V LS +YL KLKT+ +++R
Sbjct: 1105 RSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVR 1164
Query: 1124 GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA 1183
Q AE +++ +E +L + + V A L LEA ++L+ + + + F L +E+ A
Sbjct: 1165 SIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224
Query: 1184 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1243
+ V E++ + ER++++ER++E+ +QL ERW V+AQ ++RQ ELE + L YR
Sbjct: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284
Query: 1244 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI 1303
L W+++ +QE ++ DS+ + EQL Q+ AL EIER+ K+++CQ+F++QY
Sbjct: 1285 GTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYS 1344
Query: 1304 NAIKDYELQLVTYKAQLE-PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK 1362
+KDYELQL+TYKA +E SP K+ ++ S S+++ QE++DLRT Y+ L TLT+Q++K
Sbjct: 1345 TIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVK 1404
Query: 1363 FISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEAHAQAKAQAEREAKE 1419
+IS+ LRR+EEEE++ E+++ E E++ E+ + L + Q ++ K + E
Sbjct: 1405 YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI 1464
Query: 1420 LQQR-MQEEVVRREEAAVDA----------------QQQKRSIQEELQQLRQSSEAEIQA 1462
L+Q+ + EE+ ++E +A +++K+ I E+L L ++
Sbjct: 1465 LEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDG 1524
Query: 1463 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQ 1520
A Q + + S+L + E + ++ Q +Q +L + +AE A A Q R Q
Sbjct: 1525 SANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL----EDLCSWVGQAERALAGHQGRTTQ 1579
Query: 1521 EEAERLR------RQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQA 1572
++ L+ + +QD+ Q + + + ++ E + K R L AL E QA
Sbjct: 1580 QDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQA 1639
Query: 1573 EE------AERRLRQAEVERARQVQVALETAQRSAEAELQSKR----------ASFAEKT 1616
+E E R+ Q E+E A + ET + A EL + S
Sbjct: 1640 KEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSG 1699
Query: 1617 AQLERSLQ-EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
QL +L E ++ A L + A +A E+ +++ E + + E L Q
Sbjct: 1700 GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLS---QQ 1756
Query: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1733
+ AQA ++ EEQ + Q++L E + + LA+ A+
Sbjct: 1757 QNFILATQSAQAFLDQHGHNL--------TPEEQQMLQQKLGELKEQYSTSLAQSEAELK 1808
Query: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-----EAAAATQKRQ-ELEAELAKV 1787
Q + EL + + ++ E + E+EL + + E + KRQ ++
Sbjct: 1809 QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH 1868
Query: 1788 RAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFRELAEEAARLRA--- 1835
+ ++ + S + + S E K +L+ R+ L + RL +
Sbjct: 1869 KGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN 1928
Query: 1836 --LAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAA----IGEATRLKTEAEIALKEKE 1887
L + + Q A Q EA E++L++ +A+ + E + + L E +
Sbjct: 1929 MLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQ 1988
Query: 1888 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKASDSELERQKGLVEDT 1943
E+L+++A D +E + A ++E L+ + S S ER L++
Sbjct: 1989 VPVEKLQKVARD----IMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAER-SSLLQKA 2043
Query: 1944 LRQRRQVEEEILALKASF---EKAAAGKAELELELGRIRSNAEDTLR-----SKEQAELE 1995
+ Q + V+E + +L S E+ GK L G I+ ++ +++++ LE
Sbjct: 2044 IAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE 2103
Query: 1996 AARQ----------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045
A R+ AA + + E +R ++ ++E K L + E +
Sbjct: 2104 ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS 2163
Query: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV--- 2102
+ ++ E + A Q Q+ Q +E QQ+ + + L E S
Sbjct: 2164 GKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGF 2223
Query: 2103 ---LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---------- 2149
L Q + + R+ E ++ + E++A+ + Q++E +L ++ +
Sbjct: 2224 ALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI 2283
Query: 2150 ---EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE---- 2202
E + + + + E L+ + A++ E+ + + ME ++
Sbjct: 2284 PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTG 2343
Query: 2203 ----------------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246
T + +++ +++ + L+ E+ + E LQ + E
Sbjct: 2344 SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV 2403
Query: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
++ + V + L S ++ + + + + E L++ + K+++V E
Sbjct: 2404 HKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA 2463
Query: 2307 AARLSVA---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL----KAEAELL 2359
A L V +QEA +++ EE ++ E + + Q + A+ L AE++L
Sbjct: 2464 LAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLR 2523
Query: 2360 Q--QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
+KEL L D + Q ++ Q + EA RQ+ +++ A+ +
Sbjct: 2524 PWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPG 2582
Query: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELATQ----------------EKVTLV-Q 2459
++S + ++ +++ Q ++ E+ +KL+ R+ Q EKV V Q
Sbjct: 2583 DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 2642
Query: 2460 TLEIQRQQSDHD--AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
L +Q S ++ E +E+ + E+L E K Q +E+ + EQ L
Sbjct: 2643 RLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYL----- 2697
Query: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
KD L +R + LE L D + + Q Q+ QQ ++ R L
Sbjct: 2698 --------KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDD 2749
Query: 2578 SMEEARRR-----QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL------REQLQ 2626
+ + + E + ++ EE Q+ Q E++ E + L E+ +
Sbjct: 2750 KQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKR 2809
Query: 2627 LLEEQHRAALAHSEEVT 2643
L+ Q H EE++
Sbjct: 2810 TLQNQLVELKNHWEELS 2826
Score = 131 bits (329), Expect = 2e-29
Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)
Query: 1041 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100
E R QR++ Q + E + + + S + L A TL EL + +G+
Sbjct: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694
Query: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159
+ L ++L+T++L ++G + A + + + L Q EL
Sbjct: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750
Query: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1203
+ +A+ + L+ +L+ +E + L Q G +V E
Sbjct: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810
Query: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263
+ ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869
Query: 1264 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1322
D + L + +A+L E+E+ +E A IN+ + E + KA + +
Sbjct: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928
Query: 1323 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1380
+ + ++ + ++GS E + Q + + + + K + ++E + L Q
Sbjct: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981
Query: 1381 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1420
+ E+ EV ALE Q Q + A++E E+
Sbjct: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041
Query: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1479
+QR+ V E Q ++E QL + E+ + + +IE+
Sbjct: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100
Query: 1480 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1522
+I V++L +EA+E + G G + EL+AL + + + + QE+
Sbjct: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160
Query: 1523 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1575
E +V+D ++ + + +AEA E + Q L + ++ Q +
Sbjct: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220
Query: 1576 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
+ +L+Q +Q A ++ + E E+ ++ + +K AQ LQE +
Sbjct: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279
Query: 1631 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
+ ++ E A+ E + AE ++ + Q++ + L+ L + +
Sbjct: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337
Query: 1686 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1741
QAE + + AE R + G+ E R EL + +Q+QL + A+Q +
Sbjct: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
Query: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801
+ + TE+ + + + A++Q++ +++E V +++ ++ +
Sbjct: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454
Query: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
S + +++++ R+ E+ + R AL ++A +L ED
Sbjct: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503
Query: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
E E+ E E++ +D F++ L Q A H A + E
Sbjct: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544
Query: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
+ +K D ++ + L++ T EE+L ++ + A++ +
Sbjct: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591
Query: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041
+ LR+ EQA A + + E RE EE + S + Q + + L
Sbjct: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650
Query: 2042 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2090
K +V E R + + + S L+L A+E K + + + V + +
Sbjct: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710
Query: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2145
+Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K
Sbjct: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767
Query: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
S +E R++ + +K QE ++ ++Q +A + +++A
Sbjct: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816
Query: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265
++AQV L Q ET + + EE + L A+ A Q+ ++ +R E
Sbjct: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870
Query: 2266 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2324
+++ K I+ +L+ + EE E +++ ++A + +E R R LA
Sbjct: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
Query: 2325 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2372
+E ++Q + E + + E ++ + R + AE + +++ + A + +
Sbjct: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985
Query: 2373 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2420
LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++
Sbjct: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
Query: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2474
+ D ++ + +H E +++V +T++ + + E
Sbjct: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
Query: 2475 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529
+R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L
Sbjct: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164
Query: 2530 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
+++ KL + +D++ + ++ + E +QQ +ME+ + ++
Sbjct: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
Query: 2581 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2634
+A E + + R E L +L+ E +A +L Q Q E+ +
Sbjct: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279
Query: 2635 ALAHSEEVTASQ 2646
L H+EE+ +Q
Sbjct: 4280 WLTHTEELLDAQ 4291
Score = 129 bits (325), Expect = 5e-29
Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)
Query: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV
Sbjct: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259
Query: 293 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 349
Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q
Sbjct: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317
Query: 350 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 390
+ + E+ + ++ + Q V+ +L++ PG
Sbjct: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377
Query: 391 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 441
+D+ + L + K + RLE +++V + + E +E L
Sbjct: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437
Query: 442 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 488
L ++ GK + D++KA ++L ++ T K+
Sbjct: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492
Query: 489 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 546
+H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + +
Sbjct: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549
Query: 547 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 602
+T + L+DL +WV + + + G + DL +++ + L I+
Sbjct: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609
Query: 603 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 649
D + +LSP A R+ L + QY L ++ + LE +
Sbjct: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
Query: 650 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 700
+ A KEL +K + VG TN+ ++ A + + L
Sbjct: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
Query: 701 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 760
+ A ++L D Q L Q +++L A A Q ++
Sbjct: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779
Query: 761 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 817
E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K
Sbjct: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836
Query: 818 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 874
+L+ H LP LL +V HKGD + Q KVL S
Sbjct: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890
Query: 875 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 925
E PS + LV ++A E T RL + L+ +HQ SL AW Q+
Sbjct: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950
Query: 926 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 976
+V+ + S ++A+ T K ++ A H + + Q RD + G
Sbjct: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010
Query: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1036
D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ +
Sbjct: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066
Query: 1037 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1090
L+ + + + Q+A A L + +AR L A E V E S A L
Sbjct: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124
Query: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1148
+ +L + EQ L EK ++ ++ + E + ++ ++ + A+
Sbjct: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
Query: 1149 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1206
P+ + T +++L + E QQ D L + G L ++ + ++
Sbjct: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232
Query: 1207 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1266
RV L + + + R+++ QL +R+ WL++ + A
Sbjct: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292
Query: 1267 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1326
+ + +Q+ ++LL++ G VEE N I + +T S
Sbjct: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345
Query: 1327 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386
GS + DL +++ + +Y K R E + + + +
Sbjct: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405
Query: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
E + ++ K+ L A + K + + + E+ + Q+ K ++
Sbjct: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465
Query: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506
L S EAE K ++ EL +
Sbjct: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491
Query: 1507 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1564
RA E A++RQ +E A L ESQ R E EL V A +
Sbjct: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551
Query: 1565 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1619
+ L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L
Sbjct: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609
Query: 1620 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1671
RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R
Sbjct: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
Query: 1672 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1729
L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L
Sbjct: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728
Query: 1730 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1787
A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L +
Sbjct: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784
Query: 1788 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844
EV++A E ES S + K+ L+ + + EE ++ + A RQ
Sbjct: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834
Query: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1903
+L + Q+A+ + E L E + K +E + L + E+ LR A +
Sbjct: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891
Query: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1963
+RR + ADI L +A + + +K + + V EE+ A S E+
Sbjct: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945
Query: 1964 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
E + I E +K Q E+ A Q + + + A++ V ++L
Sbjct: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
Query: 2024 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2083
+ + R L E +A +L +AE L++ Q + E K
Sbjct: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058
Query: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2143
+ Q +++ Q + D+L G R + ++ QS Q+E+
Sbjct: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102
Query: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2202
KL EA + R E+ L E+E +K+ +
Sbjct: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149
Query: 2203 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
T R KA+ EQ ELT R++ D + L AE EA + E E+ + +
Sbjct: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
Query: 2262 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2303
+ Q E++ L+ +++ N + LI KD + L+ + E++ K+V
Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
Query: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363
A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK
Sbjct: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321
Query: 2364 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2422
L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A
Sbjct: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374
Query: 2423 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2474
AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A
Sbjct: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431
Query: 2475 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2533
L E ++E + Q K+ Q L T +Q LSEK DSL R
Sbjct: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476
Query: 2534 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
I+ + L ++ A+ E++
Sbjct: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505
Query: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2653
E L L + + + ++ ++ +L QH LA +EE+ + + +
Sbjct: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556
Query: 2654 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701
NG+ L E + DG++ R + + S++ L+ L Q
Sbjct: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601
Score = 100 bits (249), Expect = 3e-20
Identities = 316/1613 (19%), Positives = 616/1613 (38%), Gaps = 239/1613 (14%)
Query: 1053 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1108
Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++
Sbjct: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279
Query: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168
+ + L+ + + T EE++ + E + V A + E K L+ +
Sbjct: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329
Query: 1169 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1224
++ T D L+ E G R+ Q D RE++ LE RW +L++
Sbjct: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376
Query: 1225 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+
Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435
Query: 1285 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1334
IE H V + + A+Q + + K LQ + Q A + S
Sbjct: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
Query: 1335 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
+ ++ V++ +E+ L+S ++K + + + + LA + R++ + +
Sbjct: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554
Query: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1447
A Q L + + + + ++ R + V +A +Q + +S E
Sbjct: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614
Query: 1448 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501
EL + E E+ Q+ E + + +++E+ RL L+ T + A E
Sbjct: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673
Query: 1502 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
L RAR +A Q + + + ++ QR +Q E AE
Sbjct: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729
Query: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1612
E +R L AL +RL E ++ Q +V++A + + + + EL S R+
Sbjct: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783
Query: 1613 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667
+KT E+ SL +++ A++ L E R ++ E EL W ++
Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842
Query: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1719
AL +L + + ++ Q E +Q E+ E + + +E + E+ E+
Sbjct: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
Query: 1720 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1770
+ +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+
Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962
Query: 1771 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1825
A K +E ++ E+E L S K R EE RS + + +
Sbjct: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022
Query: 1826 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1875
+ ++A AEE + + +LAE+ A + + + L + G + + +
Sbjct: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082
Query: 1876 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1928
K + E A KE E E +R L D F E+ + D + L K
Sbjct: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142
Query: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
LE+ +ED ++ Q ++ + A+ + + +G + +D L
Sbjct: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197
Query: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E
Sbjct: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251
Query: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2108
++ R + L L Q Q +EL L + +LD R
Sbjct: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293
Query: 2109 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
E E A+ + + QA E E L+ SA + A +
Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349
Query: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2220
A + + Q+ R Q Q+ L+Q Q +E+E ELT +
Sbjct: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395
Query: 2221 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2280
QL + L E AR++ EL+ S+LKA+ E N+
Sbjct: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434
Query: 2281 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2340
L DK ++++ + + A L + + + L + LA +
Sbjct: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQN 4491
Query: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
+ + T L +Q +A + L Q+ EE + F + A R
Sbjct: 4492 SLQEFINWLT-------LAEQSLNIASPPSLILNTVLSQI-----EEHKVFANEVNAHRD 4539
Query: 2401 RQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451
+ +E+ +LK + + Q+R E+ QR ++ + + R +
Sbjct: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 4599
Query: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2511
+ L+ LE DAE ++ E+ + +K++ + L E +T+ +Q
Sbjct: 4600 EAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHKEFQKTLGGKQP 4648
Query: 2512 LQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559
+ +T +AL++ L +DS + + F+ + + K + + V + +L E
Sbjct: 4649 VYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQHKLEE 4700
Score = 67.0 bits (162), Expect = 4e-10
Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)
Query: 947 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 1003
EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A
Sbjct: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922
Query: 1004 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1055
E I+E D I LE E + RLR +P + + REC I++ +
Sbjct: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978
Query: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1111
A E+E L L E+++ + + AA ++ +L+ + E +++
Sbjct: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038
Query: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1171
++ L + L + +L +K+ Q + L + +K+ AE +
Sbjct: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
Query: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
D L +EL + +G L GE E R+ + ++ W+ + R +LE
Sbjct: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152
Query: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1289
+ Y+++ + WL + ++ MP D V++QL + + E+ +
Sbjct: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207
Query: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
Q+ + +N + L+ T + + + P + K + + E + R H
Sbjct: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258
Query: 1350 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1407
E L Q+ + E + + E L + QR + ++ EVE LA+ H
Sbjct: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310
Query: 1408 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1466
+ A + E + E++ E +A D RS E + Q +S + + + +Q
Sbjct: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368
Query: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526
++ + EI L+L E Q + + E A Q E +L
Sbjct: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424
Query: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1584
+ + + +Q + + L SR + + + E+ AL Q + + EE + +L +A +
Sbjct: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483
Query: 1585 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643
A + Q +L E AE AS S EEH A E Q
Sbjct: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540
Query: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1702
E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++
Sbjct: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597
Query: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762
+A ++ + E AE L+ + +++ + +L + + +T G+Q
Sbjct: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655
Query: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1819
R +E + Q+L+ L +VR + + + + EE+ S + L+A
Sbjct: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
Query: 1820 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1862
++ + A + + Q++L + Q R E
Sbjct: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
Query: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1921
+ G+ L T + K ++ RL + L + E F R + ++ E+
Sbjct: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833
Query: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
L + R A + E + L++ ++VEE+ + + ++ A + +
Sbjct: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892
Query: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 2035
+R++ + L A+Q Q E A + + L A + A R ++
Sbjct: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952
Query: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
+ ++R+KA + E + E ++ ++ + +K + E HA +++ +++
Sbjct: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009
Query: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2149
L Q + ++EA + Q A + +R++ +A +RL++ E
Sbjct: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
Score = 39.7 bits (91), Expect = 0.070
Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 4506 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4557
S S GS AGSR GSR SR GS FD T S S T SS+ G RR
Sbjct: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403
Score = 34.3 bits (77), Expect = 2.9
Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)
Query: 532 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 584
+V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
Query: 585 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 638
H+ G Q + + + RA ++ L P + LG + ++ + S R
Sbjct: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694
Query: 639 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 690
LE F+ A + WL + E E++ D N+ +++ +
Sbjct: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751
Query: 691 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 750
EL + ++ L+ +G L+ V+ L T+W + +L ++ L++
Sbjct: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811
Query: 751 YFQFFSD 757
+ F D
Sbjct: 4812 QAEVFRD 4818
>gi|207452735 epiplakin 1 [Homo sapiens]
Length = 5090
Score = 1268 bits (3280), Expect = 0.0
Identities = 798/1967 (40%), Positives = 1134/1967 (57%), Gaps = 218/1967 (11%)
Query: 2664 AAEAEP-EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2722
AAE +P + +F GLR++VSA+ L A ++S + L L+QG TTV E+A + V+ L+G
Sbjct: 1511 AAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGG 1570
Query: 2723 SSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVK 2782
+ IAG+L++ T E++S+ AL+R +L PGTAL+LLEAQAA+GF++DP NR+LTV EA K
Sbjct: 1571 NFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFK 1630
Query: 2783 EGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGV 2842
G+ G E + KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGG+
Sbjct: 1631 AGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGI 1690
Query: 2843 IDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDP 2902
IDPVHSHRVPVDVAYR GYFDEEMNR+LADPSDDTKGFFDPNTHENLTYLQLLERCVEDP
Sbjct: 1691 IDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDP 1750
Query: 2903 ETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTA 2962
ETGL LL + KG VY + R V + T G+F + V+ W++++S YFT
Sbjct: 1751 ETGLYLLQI---IKKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTE 1807
Query: 2963 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQE-QKGRLCFEGLRSLVPAAELLESRVIDR 3021
+++R+L++++ +EK+++II T +EE E Q + +R V AA+L SRVID+
Sbjct: 1808 DRKRELIQEYGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQ 1867
Query: 3022 ELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMA 3081
+ L+ G + ++ ++ V+ L G++ IAGV + + +S++ A +K+L+P+ A
Sbjct: 1868 KTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927
Query: 3082 VALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSV 3141
LLEAQA TG ++DP T +L+VDEAV GLV E E+LL AE+A TGYRDP TG ++
Sbjct: 1928 TWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTI 1987
Query: 3142 SLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAP 3201
LFQA++K LI + + LRLL+ Q++TGG++DP HR+PL+ A RGCL ++ +S
Sbjct: 1988 PLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQ 2047
Query: 3202 RADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETF 3261
+ K + DP+T E +Y ELQ+RCRP + TG L P++ KAAR + + + + R
Sbjct: 2048 KHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVN-KAAR---DSEHIDDETRRAL 2103
Query: 3262 EKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT-GKVTVEKVIKILITIVE 3320
E VE+ VG F+G+ T+W L++SEY T E++ +L+R +RT + ++ V ++++ ++E
Sbjct: 2104 EAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILELIE 2163
Query: 3321 EVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQG 3380
+ ET + L F G+R + ASELL+S +++ + L+ G++T ++L E V+ L+G
Sbjct: 2164 KQET-SNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEG 2222
Query: 3381 SGCLAGIYL-----EDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLY 3435
+ C+AG+ + +EK+SIY+AM +G+LR TA +LLEAQAATGF++DPVRN RL
Sbjct: 2223 TSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLS 2282
Query: 3436 VHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQ 3495
V E V AGVVG E+ E+LLSAE+AVTGY DPY+G ISLFQAMQK L++R+HGIRLLEAQ
Sbjct: 2283 VEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQ 2342
Query: 3496 IATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLE 3555
IATGG+IDPVHSHRVPVDVAY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL
Sbjct: 2343 IATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLR 2402
Query: 3556 RCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLW 3615
RCV DP+TGL +L L G A EE R A + ++ PG G+ G ++S+W
Sbjct: 2403 RCVPDPDTGLYMLQLAGRGSA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVW 2455
Query: 3616 EVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLT 3675
E++ + E++R L++ ++AG +T E + + ++ + + + R
Sbjct: 2456 ELLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQ------------AQARAE 2503
Query: 3676 AEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQ 3735
A EA + LR T ++ G + G +P ++
Sbjct: 2504 A----EAGSPRPDPREALRAATMEVK--------------VGRLRGRAVP-------VWD 2538
Query: 3736 ALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER 3793
L G +S AR L A+ +G L P RLT ++EA P+L D
Sbjct: 2539 VLASGYVS-RAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDARRGPRE 2597
Query: 3794 ---AVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV 3849
A G D Q + +E A R + L + R F P+ V
Sbjct: 2598 PGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSV 2657
Query: 3850 --AYQRGYLNKDTHDQ-----------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDG 3896
YL++ D+ L + V + V T+ERLS
Sbjct: 2658 WDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLS------------- 2704
Query: 3897 TGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQK 3954
K++FRGLR+Q++ EL S ++ T L +G +++EVT+ ++++
Sbjct: 2705 ------------KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKR 2752
Query: 3955 FLEGTSCIAGVFVDA-----TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 4009
+LEGTSCIAGV V A +E++S+YQAM KG++RPGTA LLEAQAATG+VIDP++
Sbjct: 2753 YLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRN 2812
Query: 4010 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4069
L+L+VEEAV G+VG E ++KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRL
Sbjct: 2813 LRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRL 2872
Query: 4070 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4129
LEAQIATGG+IDP SHR+PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTY+
Sbjct: 2873 LEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYV 2932
Query: 4130 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPET----GKEMSVYE-- 4183
QL+ RC+ DP TGL +L L + S+ R V P + G+ +SV+E
Sbjct: 2933 QLLRRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELL 2992
Query: 4184 ---------------AYRKGLIDHQ------TYLELSEQECEWEEITISSS--------D 4214
YR G + + T L Q E S
Sbjct: 2993 FYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALR 3052
Query: 4215 GVVKSMIIDRRSGRQYDIDDAIAKNLIDRSA----LDQYRAGTLSITEFADMLS------ 4264
+ + R GR + D +A + +A L ++ +GTL + L+
Sbjct: 3053 AATMEVKVGRLRGRAVPVWDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAIIEEA 3112
Query: 4265 ---------------------------GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASW 4297
G++G + G + + A +R Q +
Sbjct: 3113 EEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQEQTL 3172
Query: 4298 SDPTEET--GPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGI------- 4348
D T E G G VS+ + + + + LL AQ G +
Sbjct: 3173 RDATMEVQRGQFQG-------RPVSVWDVLFSSYLSEARRDELL-AQHAAGALGLPDLVA 3224
Query: 4349 ----IDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKG 4404
+ T ER ++ +GL ++ ++ + G P T ++ +
Sbjct: 3225 VLTRVIEETEER--LSKVSFRGLRRQVSASELHTS-----GILGPETLRDLAQGTKTLQE 3277
Query: 4405 WLYYEAGQRFLEVQYLTGGLIEP--DTPGR---VPLDEALQRGTVDARTAQKLRDVGAYS 4459
++ +R+LE G++ P D PGR + + +A+ +G + TA L + A +
Sbjct: 3278 VTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAAT 3337
Query: 4460 KYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYS 4506
++ P L++S ++A+ +V +LL +A ++ GY PY+
Sbjct: 3338 GFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL-SAERAVTGYTDPYT 3383
Score = 1179 bits (3049), Expect = 0.0
Identities = 740/1890 (39%), Positives = 1067/1890 (56%), Gaps = 172/1890 (9%)
Query: 2672 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2731
+F + VSA L E GIL + +Q L +G +++ R +VR YL+G S+AG++L
Sbjct: 234 TFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLL 293
Query: 2732 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2791
K S + A LL GTAL LLEAQAA+ L+DP+ +RL V+EAV+ G+V PELH
Sbjct: 294 PEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELH 353
Query: 2792 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2851
+LL AE+AVTG+ DP++G QI LFQAM+KGL+ R +RLL+AQ+ATGG++ P R+
Sbjct: 354 EQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRL 413
Query: 2852 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2911
P++ A R G DE+ R L+ G F TH L Y QLL CV DPETGL LPL
Sbjct: 414 PLEAALRCGCLDEDTQRQLSQA-----GSFSDGTHGGLRYEQLLALCVTDPETGLAFLPL 468
Query: 2912 TDKAAKGGELV---YTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDL 2968
+ +GGE + R AT + GKF+G+ V++WE++ SE ++EQR L
Sbjct: 469 SG-GPRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAISSEQRAML 527
Query: 2969 LRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQ 3028
+Q++ G ++VEK+ + +E+ R+ F GLR V ELL++ +ID++LY++L+
Sbjct: 528 AQQYQEGTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLE 587
Query: 3029 RGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQ 3088
G+ + +DV + + +R L+G IAG+ L + ++LSIY A K LL A+ LLEAQ
Sbjct: 588 HGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQ 647
Query: 3089 AGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3148
A TG IIDP + +V+EA+RA ++GP+ KLLSAE+AVTGY DPYTGQ +SLFQA++
Sbjct: 648 AATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQ 707
Query: 3149 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3208
KGLI RE G+RLL+AQ++TGG++DP SHRVP+DVA RG D+ + L P D K +
Sbjct: 708 KGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGF 767
Query: 3209 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3268
DP+T E TY +L +RC D TGL LLPLS + Q L + ++ F+ + V
Sbjct: 768 FDPNTHENLTYLQLLERCVRDPETGLYLLPLS-----STQSPLV-DSATQQAFQNLLLSV 821
Query: 3269 PVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQE 3328
G F+G+ V+ WELI+SEYF+ +R++LLR++R +VT+ +V K+L E ET RQ
Sbjct: 822 KYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREVTLGQVAKLL-----EAETQRQA 876
Query: 3329 RLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIY 3388
+ LR+ V +LL +G++ + +Q+ G + + L + VR L G G + G+
Sbjct: 877 DIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVR 936
Query: 3389 LEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPE 3448
L + +++S+Y+AMR+ LL A LLEAQAATG ++DP + L V EAV+ GVVGPE
Sbjct: 937 LLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPE 996
Query: 3449 LHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSH 3508
L+ +L AE A+ G+RDP+SG +S+FQAM+KGL+ + RLLEAQ+ATGGIIDP H
Sbjct: 997 LYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHH 1056
Query: 3509 RVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3568
+P+ VA QRGY +EM L+ S+ F P+ +Y QLLE C D +GL LL
Sbjct: 1057 HLPMPVAIQRGYVDQEMETALSSSSET---FPTPDGQGRTSYAQLLEECPRDETSGLHLL 1113
Query: 3569 PLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQR 3628
PL + A + TEE+ +R+ + +PG SLW+++ S EEQR
Sbjct: 1114 PLPESAPA-------LPTEEQVQRSLQA----VPG----AKDGTSLWDLLSSCHFTEEQR 1158
Query: 3629 AQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLE 3688
L+ D Q GR T +++ + +++T+++ Q R + A L +A II+ E
Sbjct: 1159 RGLLEDVQEGRTTVPQLLASVQRWVQETKLL-AQARVMVPGPRGEVPAVWLLDAGIITQE 1217
Query: 3689 TYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVAR 3748
T L +GT+S + E + L+GTG VAGV L S SI QA++ GLL + +
Sbjct: 1218 TLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQ 1277
Query: 3749 LLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTIS 3808
LLEAQ A+GFL+DP+ +RL+V++AV+ GLVG EL ++L AERA GY DPY+ ++S
Sbjct: 1278 RLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAAGYPDPYSRASLS 1337
Query: 3809 LFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSE-P 3867
L+QAM+K L+P E L LL QLATGG+VDP G HLP A + G L+ T L+
Sbjct: 1338 LWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLLDTQTSQVLTAVD 1397
Query: 3868 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--------SDARKLTFRGLRKQI 3919
+ + + DPS ++++Y QL RC D TG LLLPL D + R ++ +
Sbjct: 1398 KDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDHTAVALRAMKVPV 1457
Query: 3920 T---------------MEELVRSQVMDEATAL----------QLREGLTSIEEVT----- 3949
+ + E V + E AL Q+ +T++ E
Sbjct: 1458 STGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQVVSAVTALVEAAERQPL 1517
Query: 3950 ------------------------KNLQKFLEGTSCIAGVF-VDATKERL---------- 3974
K L + +GT+ + V +D+ K L
Sbjct: 1518 QATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVL 1577
Query: 3975 --------SVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPE 4026
S+ +A+++ I+RPGTA LLEAQAATG++IDP + KLTVEEA + G+ G E
Sbjct: 1578 IQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKE 1637
Query: 4027 FKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESH 4086
KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIATGGIIDP SH
Sbjct: 1638 TYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSH 1697
Query: 4087 RLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLL 4146
R+PV+VAY+ G FDEEMN IL DPSDDTKGFFDPNT ENLTYLQL+ERC+ DP+TGL LL
Sbjct: 1698 RVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLL 1757
Query: 4147 PLKEK-------KRERKTSSKSSVRKRRV-----------------VIVDPETGKEMSVY 4182
+ +K + +S K RV + + + Y
Sbjct: 1758 QIIKKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTEDRKRELIQEY 1817
Query: 4183 EAYRKGLIDHQTYLE-----LSEQECEWEEITISSSDGVV------KSMIIDRRSGRQYD 4231
A GL + LE + E E + + I +++ G V S +ID+++
Sbjct: 1818 GAQSGGL---EKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQKTLHTLR 1874
Query: 4232 IDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSR 4291
+ + L + Y G +D ++G S+ +S + PA
Sbjct: 1875 VGRTGGQALSTLECVKPYLEG-------SDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927
Query: 4292 TQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDP 4351
T L E +LD T +K+S+ EA+ LV+ +RLL+A+ G DP
Sbjct: 1928 TWL------LEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDP 1981
Query: 4352 STGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAG 4411
+TG+ P+ A+ K L++K R+ Q A G DP+ ++ A ++G L+ +
Sbjct: 1982 ATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIY 2041
Query: 4412 QRFLEVQYLTGGLIEPDTPGRVPLDEALQR 4441
+ +++ ++P+T +V E +R
Sbjct: 2042 ALISDQKHMRKRFVDPNTQEKVSYRELQER 2071
Score = 1138 bits (2943), Expect = 0.0
Identities = 742/1981 (37%), Positives = 1094/1981 (55%), Gaps = 185/1981 (9%)
Query: 2623 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA 2682
EQ +L +Q++ E++ A++++AT L+ AA A +F GLR V+
Sbjct: 522 EQRAMLAQQYQEGTLSVEKL-AAELSAT---------LEQAAATARV--TFSGLRDTVTP 569
Query: 2683 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA 2742
L +A I+ + +RL G T ++ + YLQG IAGLLL + E+LS+Y A
Sbjct: 570 GELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEA 629
Query: 2743 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVT 2802
+ LL PGTALILLEAQAA+GF++DP N+ +V EA++ V+GP++ KLLSAERAVT
Sbjct: 630 RCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVT 689
Query: 2803 GYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 2862
GY DPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF
Sbjct: 690 GYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 749
Query: 2863 DEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELV 2922
D+ +N +L DPSDDTKGFFDPNTHENLTYLQLLERCV DPETGL LLPL+ +
Sbjct: 750 DQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLSSTQSP----- 804
Query: 2923 YTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKI 2982
DS + F+ +S +G+FQG+ V+ WE+INSEYF+ +RR LLR++R +T+ ++
Sbjct: 805 LVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREVTLGQV 864
Query: 2983 IKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDT 3042
K++ E +++ + LRS V +LLE+ +ID++L Q+ G S + +D
Sbjct: 865 AKLLEA---ETQRQADIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDG 921
Query: 3043 VRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSAR 3102
VRR L G + GV L +GQ+LS+Y A+++ LL +A+ALLEAQA TG I+DP +
Sbjct: 922 VRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPES 981
Query: 3103 LTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLD 3162
L+VDEAVR G+VGPE + +L AE A+ G+RDP++G+ VS+FQA+KKGLIP EQ RLL+
Sbjct: 982 LSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLE 1041
Query: 3163 AQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGEL 3222
AQ++TGGI+DP+ H +P+ VA RG +D+E ALS+ ++ + P +Y +L
Sbjct: 1042 AQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSS---SSETFPTPDGQGRTSYAQL 1098
Query: 3223 QQRCRPDQLTGLSLLPLSEKA-ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVW 3281
+ C D+ +GL LLPL E A A +E++ LQA V G K T ++W
Sbjct: 1099 LEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQA------------VPGAKDGT-SLW 1145
Query: 3282 ELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPA 3341
+L+SS +FT EQR+ LL + G+ TV +++ + V+E + L Q R+ G R VPA
Sbjct: 1146 DLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGEVPA 1205
Query: 3342 SELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEA 3401
LL +G++++ E L G + ++E +V+ L G+GC+AG+ L+ + K SI +A
Sbjct: 1206 VWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQA 1265
Query: 3402 MRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVT 3461
+R GLL LLEAQ A+GFLVDP+ NQRL V +AVK G+VG EL EQL AE+A
Sbjct: 1266 VRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAA 1325
Query: 3462 GYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYF 3521
GY DPYS +++SL+QAM+KGLV + G+ LL+ Q+ATGG++DPVH +P A + G
Sbjct: 1326 GYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLL 1385
Query: 3522 SEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVET 3581
+ ++VL D K FFDP+ + +TY+QL ERCV D ETGL LLPL EV +
Sbjct: 1386 DTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDH 1445
Query: 3582 TQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVT 3641
T V A ++ + G G ++SLW+++ S+ + ++R +L+A ++GR
Sbjct: 1446 TAV--------ALRAMKVPV-STGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAA 1496
Query: 3642 KERMII-IIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSL 3700
R ++ + ++E E RQ A++ +R++++A DLF A++IS +T + L +GT ++
Sbjct: 1497 ALRQVVSAVTALVEAAE--RQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTV 1554
Query: 3701 REALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFL 3760
+E E +S L G +AGV + G+++ +SI +AL++ +L A +LLEAQAATGF+
Sbjct: 1555 KEVAEMDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFI 1614
Query: 3761 LDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPT 3820
+DP + +LTV+EA + G+ G E + +LLSAERAVTGY DPYT Q ISLFQAM+K+LI
Sbjct: 1615 IDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVR 1674
Query: 3821 EEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSE-VRSYVDPSTD 3879
E +RLL+AQ+ATGGI+DP +P++VAY+ GY +++ + L++PS+ + + DP+T
Sbjct: 1675 EHGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTH 1734
Query: 3880 ERLSYTQLLRRCRRDDGTGQLLLPL--------------------SDARKLTFRGLRKQI 3919
E L+Y QLL RC D TG LL + A+ R + +
Sbjct: 1735 ENLTYLQLLERCVEDPETGLYLLQIIKKGENYVYINEATRHVLQSRTAKMRVGRFADQVV 1794
Query: 3920 TMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQA 3979
+ +L+ S E + RE + + L+K LE + +E + Q
Sbjct: 1795 SFWDLLSSPYFTED---RKRELIQEYGAQSGGLEKLLE-------IITTTIEETETQNQG 1844
Query: 3980 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT 4039
+K IR E+ A VID L V + E L +
Sbjct: 1845 IKVAAIRG----EVTAADLFNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSDCIA 1900
Query: 4040 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF 4099
G P + +++SL +A +K LI LLEAQ ATG ++DP +L V+ A GL
Sbjct: 1901 GVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLV 1960
Query: 4100 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSS 4159
+EE+ E L G+ DP T + + Q M++ + + L LL
Sbjct: 1961 NEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLL------------- 2007
Query: 4160 KSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKS 4219
V+ ++DP+ + + AYR+G + Y +S+Q+ + ++ V
Sbjct: 2008 --EVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSY 2065
Query: 4220 MIIDRRSGRQYD---IDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSS 4276
+ R Q D + + K D +D L A+ + G FR + +
Sbjct: 2066 RELQERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALE----AEQVEITVGRFRGQKPT 2121
Query: 4277 VGS--SSSYPISP------AVSRT----------QLASWSDPTEET--------GPVAGI 4310
+ + +S Y + RT QL +ET G I
Sbjct: 2122 LWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQI 2181
Query: 4311 LDTETLEKVSITEAM----------HRNLVDNITGQRLLEAQACTGGII-----DPSTGE 4355
+E L ITE M + L+++ +R LE +C G++ P E
Sbjct: 2182 TASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQE 2241
Query: 4356 RFPVTDAVNKG-------------------LVDKIMVDRINL------------------ 4378
+ + A+ KG ++D + R+++
Sbjct: 2242 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLL 2301
Query: 4379 -AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDE 4437
A++A G+ DP T ++S QA++K + E G R LE Q TGG+I+P RVP+D
Sbjct: 2302 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 2361
Query: 4438 ALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQS 4497
A +RG D + L D +K P T ++Y L R + + TGL +L+ A +
Sbjct: 2362 AYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRG 2421
Query: 4498 T 4498
+
Sbjct: 2422 S 2422
Score = 1040 bits (2688), Expect = 0.0
Identities = 679/1786 (38%), Positives = 979/1786 (54%), Gaps = 160/1786 (8%)
Query: 2799 RAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYR 2858
R++ G +GQ S++ AM++GL+ G LLEAQ ATGG++D +PV A +
Sbjct: 41 RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100
Query: 2859 RGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG 2918
+G E+ L T G+ DP E L Q + + V D G L + + A G
Sbjct: 101 QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEV--QLATG 158
Query: 2919 GELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINS-EYFTAEQRRDLLRQFRTGRI 2977
G + A+ V + G +T W ++ E T + R L R+
Sbjct: 159 GLV----DPAQGVLVAPEPACHQGLLDRET---WHKLSELEPGTGDLR--FLNPNTLERL 209
Query: 2978 TVEKIIKIIITVVEEQEQ--KGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3035
T ++++ + ++ F + V AAELLE ++D + Q L+ G +
Sbjct: 210 TYHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAV 269
Query: 3036 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3095
DV+ VRR L G +AGV L G K S + A + LLP A+ LLEAQA T ++
Sbjct: 270 DVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLV 329
Query: 3096 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3155
DP T RL VDEAVRAGLV PE HE+LL AE+AVTG+ DP++G + LFQA+KKGL+ R
Sbjct: 330 DPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRP 389
Query: 3156 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3215
LRLLDAQL+TGG+V P++ R+PL+ A GCLDE+T R LS A ++SD + G
Sbjct: 390 LALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLS----QAGSFSDGTHGG 445
Query: 3216 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR-QEELYSELQARETFEKTPVEVPVGGFK 3274
Y +L C D TGL+ LPLS Q + + R+ V VG F+
Sbjct: 446 -LRYEQLLALCVTDPETGLAFLPLSGGPRGGEPQGPPFIKYSTRQALSTATATVSVGKFR 504
Query: 3275 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG 3334
GR V++WEL+ SE ++EQR L +Q++ G ++VEK+ L +E+ R++FSG
Sbjct: 505 GRPVSLWELLFSEAISSEQRAMLAQQYQEGTLSVEKLAAELSATLEQAAATA--RVTFSG 562
Query: 3335 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE 3394
LR V ELL + ++ + +E+L+ G+ T KD+ L S + LQG+GC+AG+ L ++E
Sbjct: 563 LRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQE 622
Query: 3395 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL 3454
++SIYEA +GLLR TA +LLEAQAATGF++DP N+ V EA++A V+GP++ +LL
Sbjct: 623 RLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLL 682
Query: 3455 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV 3514
SAE+AVTGY DPY+G ISLFQAMQKGL++R+HGIRLLEAQIATGG+IDPVHSHRVPVDV
Sbjct: 683 SAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 742
Query: 3515 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE 3574
AY+RGYF + +N +L DPSDDTKGFFDPNTHENLTY QLLERCV DPETGL LLPL +
Sbjct: 743 AYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLSSTQ 802
Query: 3575 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD 3634
V + T++AF+ + + G G +S WE++ S+ E +R QL+
Sbjct: 803 SPLV--------DSATQQAFQNLLLSVK-YGRFQGQRVSAWELINSEYFSEGRRRQLLRR 853
Query: 3635 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR 3694
++ VT ++ ++ + E RQ + +R R+T L EA II + + +
Sbjct: 854 YRQREVTLGQVAKLL-----EAETQRQADI-MLPALRSRVTVHQLLEAGIIDQQLLDQVL 907
Query: 3695 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ 3754
GT S L + YL G G+V GV L S Q LS+YQA+++ LL VA LLEAQ
Sbjct: 908 AGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQ 967
Query: 3755 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK 3814
AATG ++DP E L+VDEAVR+G+VGPEL+ RL AE A+ G+RDP++ + +S+FQAMK
Sbjct: 968 AATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMK 1027
Query: 3815 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV 3874
K LIP E+A RLL+AQ+ATGGI+DP HLP+ VA QRGY++++ LS SE ++
Sbjct: 1028 KGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSSSSE--TFP 1085
Query: 3875 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDA-----------RKL-TFRGLRKQITME 3922
P R SY QLL C RD+ +G LLPL ++ R L G + ++
Sbjct: 1086 TPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPGAKDGTSLW 1145
Query: 3923 ELVRSQVMDEATALQL----REGLTSIEEVTKNLQKFLEGTSCI---------------- 3962
+L+ S E L +EG T++ ++ ++Q++++ T +
Sbjct: 1146 DLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGEVPA 1205
Query: 3963 -----AGVFVDATKERL--------------------------------------SVYQA 3979
AG+ T E L S+ QA
Sbjct: 1206 VWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQA 1265
Query: 3980 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT 4039
++ G++ G LLEAQ A+G+++DP+ +L+VE+AV++G+VG E ++L AERA
Sbjct: 1266 VRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAA 1325
Query: 4040 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF 4099
GY DPYS +SL+QAM+KGL+ ++ G+ LL+ Q+ATGG++DP LP A + GL
Sbjct: 1326 GYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLL 1385
Query: 4100 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPL-KEKKRERKTS 4158
D + +++LT D K FFDP+ + +TY QL ERC+ D +TGL LLPL + E
Sbjct: 1386 DTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDH 1445
Query: 4159 SKSSVRKRRV-VIVDPETGKEMSVYEAYRKGLIDHQTYLEL-----SEQECEWEEITISS 4212
+ ++R +V V G +S+++ + EL S + ++ +S+
Sbjct: 1446 TAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQV-VSA 1504
Query: 4213 SDGVVKS------MIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGN 4266
+V++ R +Q D LI R LD+ GT ++ E A+M
Sbjct: 1505 VTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEM---- 1560
Query: 4267 AGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMH 4326
+V R+ E +AG+L T E++SI EA+
Sbjct: 1561 --------------------DSVKRS--------LEGGNFIAGVLIQGTQERMSIPEALR 1592
Query: 4327 RNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGF 4386
R+++ T LLEAQA TG IIDP+ + V +A G+ K ++ A++A G+
Sbjct: 1593 RHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGY 1652
Query: 4387 EDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDA 4446
DP T ++S QA++K + E G R LE Q TGG+I+P RVP+D A + G D
Sbjct: 1653 TDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDE 1712
Query: 4447 RTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLE 4492
+ L D +K P T ++Y L+R + + TGL LL+
Sbjct: 1713 EMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQ 1758
Score = 735 bits (1898), Expect = 0.0
Identities = 653/2071 (31%), Positives = 970/2071 (46%), Gaps = 337/2071 (16%)
Query: 2607 RRQQEELLAE------ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
R +EELLAE + L +L + E+ A ++ ++ + P GR
Sbjct: 2547 RAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDARRGPREPGPAGRG-- 2604
Query: 2661 DGPAAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAE-ELQR-LAQGHTT--------- 2705
DG + ++ E +G ++ +A R QE + A E+QR QG
Sbjct: 2605 DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS 2664
Query: 2706 -VDELARREDVRHYLQGRSSIAGLL------LKATNEKLSV--YAALQRQLLSPGTALIL 2756
+ E R E + + G + L+ ++ T E+LS + L+RQ+ +
Sbjct: 2665 YLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSA------- 2717
Query: 2757 LEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQ----- 2811
++ + +L P R L + V + + L + G P Q
Sbjct: 2718 --SELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQE 2775
Query: 2812 QISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLA 2871
++S++QAM KG++ + LLEAQ ATG VIDPV + R+ V+ A G E+ L
Sbjct: 2776 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL 2835
Query: 2872 DPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDV 2931
G+ DP T + ++ Q +++ + E G+ LL + A GG + D
Sbjct: 2836 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA--QIATGGVI--------DP 2885
Query: 2932 FEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVE 2991
V +G YF E R L + + +T V+
Sbjct: 2886 VHSHRVPVDVAYRRG------------YFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQ 2933
Query: 2992 EQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQ-QLQRGERSVRDVAEVDTVRRALRGA 3050
LR VP D LY QL +V ++E +R ALR A
Sbjct: 2934 L-----------LRRCVPDP--------DTGLYMLQLAGRGSAVHQLSE--ELRCALRDA 2972
Query: 3051 NVIAGVWLEEAGQKLSIYNAL---------KKDLLPSDMAVALLEAQAGTGHIIDPATSA 3101
V G + GQ +S++ L ++DLL A L + G + A
Sbjct: 2973 RVTPGSGALQ-GQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGAT-LTSLLAQA 3030
Query: 3102 RLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLL 3161
+ AG P+ E L +A V R G++V ++ L G + LL
Sbjct: 3031 QAQARAEAEAGSPRPDPREALRAATMEVKVGR--LRGRAVPVWDVLASGYVSGAAREELL 3088
Query: 3162 DAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGE 3221
A+ +G + P+ + R+ + EE A A A+ P PA G+
Sbjct: 3089 -AEFGSGTLDLPALTRRLTAII--------EEAEEAPGARPQLQDAWRGPREPGPAGRGD 3139
Query: 3222 LQ--QRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVT 3279
+ R Q G + + AA RQE+ T +EV G F+GR V+
Sbjct: 3140 GDSGRSQREGQGEGETQEAAAAAAAARRQEQ---------TLRDATMEVQRGQFQGRPVS 3190
Query: 3280 VWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPV 3339
VW+++ S Y + +R ELL Q G + + ++ +L ++EE E R ++SF GLR V
Sbjct: 3191 VWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEE-RLSKVSFRGLRRQV 3249
Query: 3340 PASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLE-----DTKE 3394
ASEL SG+L L G T+++++E+ SV+ L+G+ C+AG+ + +E
Sbjct: 3250 SASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQE 3309
Query: 3395 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL 3454
K+SIY+AM +G+LR TA +LLEAQAATGF++DPVRN RL V EAV AGVVG E+ E+LL
Sbjct: 3310 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL 3369
Query: 3455 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV 3514
SAE+AVTGY DPY+G ISLFQAMQK L++R+HGIRLLEAQIATGG+IDPVHSHRVPVDV
Sbjct: 3370 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 3429
Query: 3515 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE 3574
AY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL RCV DP+TGL +L L G
Sbjct: 3430 AYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRG 3489
Query: 3575 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD 3634
A EE R A + ++ PG G+ G ++S+WE++ + E++R L++
Sbjct: 3490 SA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVWELLFYREVSEDRRQDLLSR 3542
Query: 3635 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR 3694
++AG +T E + + ++ + + + R A EA + LR
Sbjct: 3543 YRAGTLTVEELGATLTSLLAQAQ------------AQARAEA----EAGSPRPDPREALR 3586
Query: 3695 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ 3754
T ++ G + G +P ++ L G +S AR L A+
Sbjct: 3587 AATMEVK--------------VGRLRGRAVP-------VWDVLASGYVSG-AAREELLAE 3624
Query: 3755 AATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER---AVTGYRDPYTEQTISL 3809
+G L P RLT ++EA P+L D A G D Q
Sbjct: 3625 FGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQ 3684
Query: 3810 FQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV--AYQRGYLNKDTHDQ--- 3863
+ +E A R + L + R F P+ V YL++ D+
Sbjct: 3685 GEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDELLA 3744
Query: 3864 --------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGL 3915
L + V + V T+ERLS K++FRGL
Sbjct: 3745 QHAAGALGLPDLVAVLTRVIEETEERLS-------------------------KVSFRGL 3779
Query: 3916 RKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQKFLEGTSCIAGVFVDA---- 3969
R+Q++ EL S ++ T L +G +++EVT+ +++++LEGTSCIAGV V A
Sbjct: 3780 RRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQP 3839
Query: 3970 -TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFK 4028
+E++S+YQAM KG++RPGTA LLEAQAATG+VIDP++ L+L+VEEAV G+VG E +
Sbjct: 3840 GRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQ 3899
Query: 4029 DKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRL 4088
+KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIATGG+IDP SHR+
Sbjct: 3900 EKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRV 3959
Query: 4089 PVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPL 4148
PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTY+QL+ RC+ DP TGL +L L
Sbjct: 3960 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL 4019
Query: 4149 KEKKRERKTSSKSSVRKRRVVIVDPET----GKEMSVYEA--YRKGLIDHQTYLELSEQE 4202
+ S+ R V P + G+ +SV+E YR+ D + L LS
Sbjct: 4020 AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDL-LSRYR 4078
Query: 4203 CEWEEITISSSDGVVKSMI--------------------------------IDRRSGRQY 4230
+T+ + S++ + R GR
Sbjct: 4079 A--STLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAV 4136
Query: 4231 DIDDAIAKNLIDRSA----LDQYRAGTLSITEFADMLS---------------------- 4264
+ D +A + R+A L ++ +GTL + L+
Sbjct: 4137 PVWDVLASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRG 4196
Query: 4265 -----------GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEET--GPVAGIL 4311
G++G + G + + A +R Q + D T E G G
Sbjct: 4197 PREPGPAGRGDGDSGRSQREGQGEGETQEAAAATAAARRQEQTLRDATMEVQRGQFQG-- 4254
Query: 4312 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGI-----------IDPSTGERFPVT 4360
VS+ + + + + LL AQ G + + T ER ++
Sbjct: 4255 -----RPVSVWDVLFSSYLSEARRDELL-AQHAAGALGLPDLVAVLTRVIEETEER--LS 4306
Query: 4361 DAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYL 4420
+GL ++ ++ + G P T ++ + ++ +R+LE
Sbjct: 4307 KVSFRGLRRQVSASELHTS-----GILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSC 4361
Query: 4421 TGGLIEP--DTPGR---VPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKD 4475
G++ P D PGR + + +A+ +G + TA L + A + ++ P L++S ++
Sbjct: 4362 IAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEE 4421
Query: 4476 ALDRSMVEEGTGLRLLEAAAQSTKGYYSPYS 4506
A+ +V +LL +A ++ GY PY+
Sbjct: 4422 AVAAGVVGGEIQEKLL-SAERAVTGYTDPYT 4451
Score = 727 bits (1876), Expect = 0.0
Identities = 710/2292 (30%), Positives = 1038/2292 (45%), Gaps = 316/2292 (13%)
Query: 1952 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE-QAELEAARQRQLAAEEERRR 2010
EE+ A S A +A E E G R + + LR+ + ++ R R + +
Sbjct: 3017 EELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPVWDVLAS 3076
Query: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-QLQLAQEA 2069
++ L AE + AL RL A +EEA E AR QLQ A
Sbjct: 3077 GYVSGAAREELLAEFGSGTLDLPAL--TRRLTAIIEEAE------EAPGARPQLQDAWRG 3128
Query: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2129
++ A Q+E + + Q+ + A AARR + +A ++ +R
Sbjct: 3129 PREPGPAGRGDGDSGRSQREGQGEGETQEAAAA-------AAAARRQEQTLRDATMEVQR 3181
Query: 2130 EAAQSR----------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2179
Q R + EA R + A+ A A A L + E+ R ++
Sbjct: 3182 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAV-LTRVIEETEERLSKV 3240
Query: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2239
LR +Q + +E+ +TLR AQ + L ++ E D K L E +
Sbjct: 3241 SFRGLR-RQVSASELHTSGILGPETLRDLAQGTKTLQ----EVTEMDSVKRYL-EGTSCI 3294
Query: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2299
A Q + E+ M + + AL+L + F+ +
Sbjct: 3295 AGVLVPAKDQPGRQEK--------MSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRN 3346
Query: 2300 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359
++ EEA V E ++EK+ + + A +
Sbjct: 3347 LRLSVEEAVAAGVVGGE----------------------IQEKLLSAERAVTGYTDPYTG 3384
Query: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419
QQ ++ QA M + L G R LEA Q+ + + +
Sbjct: 3385 QQ---ISLFQA---------MQKDLIVREHGI-RLLEA----QIATGGVIDPVHSHRVPV 3427
Query: 2420 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479
A R D + R A+ + + T E +T VQ L +R D D +
Sbjct: 3428 DVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLL--RRCVPDPDTGLYMLQL 3485
Query: 2480 AELEREKEKLQQEAK--LLQLKSEEMQTVQQEQLLQETQALQQSFLSE--KDSLLQRERF 2535
A +L +E + L + Q Q + + L +SE + LL R R
Sbjct: 3486 AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRA 3545
Query: 2536 IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594
+L +A+AQ Q R E + + + A+ME R V
Sbjct: 3546 GTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPV- 3604
Query: 2595 RKQEELQQLEQQRRQQEELLAE------ENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648
+ L +EELLAE + L +L + E+ A ++ +
Sbjct: 3605 --WDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRG 3662
Query: 2649 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAE-ELQR-LAQG 2702
+ P GR DG + ++ E +G ++ +A R QE + A E+QR QG
Sbjct: 3663 PREPGPAGRG--DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQG 3720
Query: 2703 HTT----------VDELARREDVRHYLQGRSSIAGLL------LKATNEKLSV--YAALQ 2744
+ E R E + + G + L+ ++ T E+LS + L+
Sbjct: 3721 RPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 3780
Query: 2745 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2804
RQ+ + ++ + +L P R L + V + + L + G
Sbjct: 3781 RQVSA---------SELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3831
Query: 2805 KDPYTGQ-----QISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRR 2859
P Q ++S++QAM KG++ + LLEAQ ATG VIDPV + R+ V+ A
Sbjct: 3832 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3891
Query: 2860 GYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGG 2919
G E+ L G+ DP T + ++ Q +++ + E G+ LL + A GG
Sbjct: 3892 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA--QIATGG 3949
Query: 2920 ELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITV 2979
+ D V +G YF E R L +
Sbjct: 3950 VI--------DPVHSHRVPVDVAYRRG------------YFDEEMNRVLADPSDDTKGFF 3989
Query: 2980 EKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQ-QLQRGERSVRDVA 3038
+ +T V+ LR VP D LY QL +V ++
Sbjct: 3990 DPNTHENLTYVQL-----------LRRCVPDP--------DTGLYMLQLAGRGSAVHQLS 4030
Query: 3039 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNAL---------KKDLLPSDMAVALLEAQA 3089
E +R ALR A V G + GQ +S++ L ++DLL A L +
Sbjct: 4031 E--ELRCALRDARVTPGSGALQ-GQSVSVWELLFYREVSEDRRQDLLSRYRASTLTVEEL 4087
Query: 3090 GTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKK 3149
G + A+ AG P+ E L +A V R G++V ++ L
Sbjct: 4088 GAT-LTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGR--LRGRAVPVWDVLAS 4144
Query: 3150 GLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYS 3209
G + R LL A+ +G + P+ + R+ + EE A A A+
Sbjct: 4145 GYVSRAAREELL-AEFGSGTLDLPALTRRLTAII--------EEAEEAPGARPQLQDAWR 4195
Query: 3210 DPSTGEPATYGELQ--QRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE 3267
P PA G+ + R Q G + + AA RQE+ T +E
Sbjct: 4196 GPREPGPAGRGDGDSGRSQREGQGEGETQEAAAATAAARRQEQ---------TLRDATME 4246
Query: 3268 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ 3327
V G F+GR V+VW+++ S Y + +R ELL Q G + + ++ +L ++EE E R
Sbjct: 4247 VQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEE-RL 4305
Query: 3328 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI 3387
++SF GLR V ASEL SG+L L G T+++++E+ SV+ L+G+ C+AG+
Sbjct: 4306 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4365
Query: 3388 YLE-----DTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKA 3442
+ +EK+SIY+AM +G+LR TA +LLEAQAATGF++DPVRN RL V EAV A
Sbjct: 4366 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4425
Query: 3443 GVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGII 3502
GVVG E+ E+LLSAE+AVTGY DPY+G ISLFQAMQK L++R+HGIRLLEAQIATGG+I
Sbjct: 4426 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 4485
Query: 3503 DPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPE 3562
DPVHSHRVPVDVAY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL RCV DP+
Sbjct: 4486 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4545
Query: 3563 TGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDL 3622
TGL +L L G A EE R A + ++ PG G+ G ++S+WE++
Sbjct: 4546 TGLYMLQLAGRGSA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVWELLFYRE 4598
Query: 3623 IPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEA 3682
+ E++R L++ ++AG +T E + + ++ + + + R A EA
Sbjct: 4599 VSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQ------------AQARAEA----EA 4642
Query: 3683 RIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLL 3742
+ LR T ++ G + G +P ++ L G +
Sbjct: 4643 GSPRPDPREALRAATMEVK--------------VGRLRGRAVP-------VWDVLASGYV 4681
Query: 3743 SAEVARLLLEAQAATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER---AVTG 3797
S AR L A+ +G L P RLT ++EA P+L D A G
Sbjct: 4682 SG-AAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRG 4740
Query: 3798 YRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV--AYQRG 3854
D Q + +E A R + L + R F P+ V
Sbjct: 4741 DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS 4800
Query: 3855 YLNKDTHDQ-----------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 3903
YL++ D+ L + V + V T+ERLS
Sbjct: 4801 YLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLS-------------------- 4840
Query: 3904 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQKFLEGTSC 3961
K++FRGLR+Q++ EL S ++ T L +G +++EVT+ +++++LEGTSC
Sbjct: 4841 -----KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSC 4895
Query: 3962 IAGVFVDA-----TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEE 4016
IAGV V A +E++S+YQAM KG++RPGTA LLEAQAATG+VIDP++ L+L+VEE
Sbjct: 4896 IAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEE 4955
Query: 4017 AVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIAT 4076
AV G+VG E ++KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIAT
Sbjct: 4956 AVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIAT 5015
Query: 4077 GGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCI 4136
GG+IDP SHR+PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTYLQL++R
Sbjct: 5016 GGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRAT 5075
Query: 4137 TDPQTGLCLLPL 4148
DP+TGL L L
Sbjct: 5076 LDPETGLLFLSL 5087
Score = 546 bits (1406), Expect = e-154
Identities = 434/1449 (29%), Positives = 677/1449 (46%), Gaps = 192/1449 (13%)
Query: 3127 KAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACA 3186
+++ G +GQ+ S++ A+++GL+P G LL+AQ +TGG+VD ++ +P+ A
Sbjct: 41 RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100
Query: 3187 RGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPL------- 3239
+G + E L A Y DP GE + + D+ G S L +
Sbjct: 101 QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGGL 160
Query: 3240 ---SEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3296
++ A + + L RET+ K L E T + R
Sbjct: 161 VDPAQGVLVAPEPACHQGLLDRETWHK-------------------LSELEPGTGDLR-- 199
Query: 3297 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3356
L ++T ++++ + L +++F + V A+ELL G+L +
Sbjct: 200 FLNPNTLERLTYHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQ 259
Query: 3357 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3416
L++G+ D+S VR L+G+G +AG+ L K S ++A LL TA LL
Sbjct: 260 GLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLL 319
Query: 3417 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3476
EAQAAT LVDP+ QRL+V EAV+AG+V PELHEQLL AE+AVTG+ DP+SGS I LFQ
Sbjct: 320 EAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQ 379
Query: 3477 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3536
AM+KGLV R +RLL+AQ+ATGG++ P R+P++ A + G E+ R L+
Sbjct: 380 AMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQA---- 435
Query: 3537 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3596
G F TH L Y QLL CV DPETGL LPL G + + + + TR+A
Sbjct: 436 -GSFSDGTHGGLRYEQLLALCVTDPETGLAFLPLSGGPRGGEPQGPP-FIKYSTRQALST 493
Query: 3597 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKT 3656
+ G G +SLWE++ S+ I EQRA L +Q G ++ E++ + +E+
Sbjct: 494 ATATV-SVGKFRGRPVSLWELLFSEAISSEQRAMLAQQYQEGTLSVEKLAAELSATLEQA 552
Query: 3657 EIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGT 3716
+ ++ +R +T +L +A II + Y L G + ++ SA YL GT
Sbjct: 553 AATAR---VTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGT 609
Query: 3717 GSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVR 3776
G +AG+ LPGS++ LSIY+A KGLL A +LLEAQAATGF++DP + +V+EA+R
Sbjct: 610 GCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALR 669
Query: 3777 KGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGI 3836
++GP++ +LLSAERAVTGY DPYT Q ISLFQAM+K LI E +RLL+AQ+ATGG+
Sbjct: 670 AAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGV 729
Query: 3837 VDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSE-VRSYVDPSTDERLSYTQLLRRCRRDD 3895
+DP +P++VAY+RGY ++ + L +PS+ + + DP+T E L+Y QLL RC RD
Sbjct: 730 IDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDP 789
Query: 3896 GTGQLLLPLSD--------ARKLTFRGLR----------KQITMEELVRSQVMDEATALQ 3937
TG LLPLS A + F+ L ++++ EL+ S+ E Q
Sbjct: 790 ETGLYLLPLSSTQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQ 849
Query: 3938 LREGLTSIEEVTKNLQKFLEG-TSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEA 3996
L E + K LE T A + + A + R++V+Q ++ GII +
Sbjct: 850 LLRRYRQREVTLGQVAKLLEAETQRQADIMLPALRSRVTVHQLLEAGII---------DQ 900
Query: 3997 QAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAM 4056
Q + I L + + VR + L AV G + SG+ +SL+QAM
Sbjct: 901 QLLDQVLAGTISPEALLLMDGVR----------RYLCGLGAVGGVRLLPSGQRLSLYQAM 950
Query: 4057 KKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKG 4116
++ L+ + LLEAQ ATG I+D
Sbjct: 951 RQKLLGPRVALALLEAQAATGTIMD----------------------------------- 975
Query: 4117 FFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETG 4176
P++ E+L+ + + R + P+ + +R + + R DP +G
Sbjct: 976 ---PHSPESLSVDEAVRRGVVGPEL--------YGRLKRAEGAIAGFR-------DPFSG 1017
Query: 4177 KEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAI 4236
K++SV++A +KGLI WE+ V IID S + AI
Sbjct: 1018 KQVSVFQAMKKGLIP-------------WEQAARLLEAQVATGGIIDPTSHHHLPMPVAI 1064
Query: 4237 AKNLIDRSALDQYRAGTLSI--------TEFADMLSGNAGGFRSRSSSVGSSSSYPISPA 4288
+ +D+ + + + T +A +L S + S P P
Sbjct: 1065 QRGYVDQEMETALSSSSETFPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPT 1124
Query: 4289 VSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG-- 4346
+ Q + + P G G + L TE R L++++ R Q
Sbjct: 1125 EEQVQRSLQAVP----GAKDGTSLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQ 1180
Query: 4347 ------------GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGF-EDPRTKT 4393
++ P P ++ G++ + ++ + ++ E P K
Sbjct: 1181 RWVQETKLLAQARVMVPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKA 1240
Query: 4394 ------------------KMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPL 4435
K S AQA++ G L GQR LE Q +G L++P R+ +
Sbjct: 1241 CLWGTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSV 1300
Query: 4436 DEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAA 4495
++A++ G V +++L + P ++ +S A+++ +V + GL LL+
Sbjct: 1301 EDAVKVGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQL 1360
Query: 4496 QSTKGYYSP 4504
+T G P
Sbjct: 1361 -ATGGVVDP 1368
Score = 459 bits (1182), Expect = e-128
Identities = 444/1446 (30%), Positives = 666/1446 (46%), Gaps = 242/1446 (16%)
Query: 2561 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620
+ +++ Q E E Q A+ ARR+ E+ +R E+Q+ + Q R +
Sbjct: 2610 RSQREGQGEGETQEAAAAAAAARRQ----EQTLRDATMEVQRGQFQGRPVSVWDVLFSSY 2665
Query: 2621 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP---EHSFDGLR 2677
L E A +E+ A A LP+ L E E + SF GLR
Sbjct: 2666 LSE-------------ARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 2712
Query: 2678 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN--- 2734
R+VSA L +GIL E L+ LAQG T+ E+ + V+ YL+G S IAG+L+ A +
Sbjct: 2713 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 2772
Query: 2735 --EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHH 2792
EK+S+Y A+ + +L PGTAL+LLEAQAA+GF++DPVRN RL+V EAV GVVG E+
Sbjct: 2773 RQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQE 2832
Query: 2793 KLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2852
KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVP
Sbjct: 2833 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2892
Query: 2853 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLT 2912
VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTY+QLL RCV DP+TGL +L L
Sbjct: 2893 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL- 2951
Query: 2913 DKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQF 2972
A +G + E R A V+ G QG++V++WE++ + ++R+DLL ++
Sbjct: 2952 --AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRY 3009
Query: 2973 RTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGER 3032
R G +TVE++ + +++ + + + R AE R RE +
Sbjct: 3010 RAGTLTVEELGATLTSLLAQAQAQAR----------AEAEAGSPRPDPREALR------- 3052
Query: 3033 SVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTG 3092
A ++ LRG V VW A +S A +++LL A+ G+G
Sbjct: 3053 ----AATMEVKVGRLRGRAV--PVWDVLASGYVS--GAAREELL----------AEFGSG 3094
Query: 3093 HIIDPATSARLT--VDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKG 3150
+ PA + RLT ++EA A P+ +D + G
Sbjct: 3095 TLDLPALTRRLTAIIEEAEEAPGARPQL--------------QDAWRG------------ 3128
Query: 3151 LIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSD 3210
PRE G + G D +S R G + ET A +A A A
Sbjct: 3129 --PREPG-------PAGRGDGDSGRSQR--------EGQGEGETQEAAAAA---AAARRQ 3168
Query: 3211 PSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQA------------R 3258
T AT E+Q+ + + + S + AR++EL ++ A
Sbjct: 3169 EQTLRDATM-EVQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLT 3227
Query: 3259 ETFEKTPVEVPVGGFKG--RTVTVWELISSEYFTAEQRQELLRQFRT-GKVT-VEKVIKI 3314
E+T + F+G R V+ EL +S E ++L + +T +VT ++ V +
Sbjct: 3228 RVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRY 3287
Query: 3315 L--------ITIVEEVETLRQERLS-----FSGLRAPVPASELLASGVLSRAQFEQLKDG 3361
L + + + + RQE++S + G+ P A LL + + + +++
Sbjct: 3288 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 3347
Query: 3362 KTTVKDLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3416
+ +V++ G V LL + G T +++S+++AM++ L+ LL
Sbjct: 3348 RLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 3407
Query: 3417 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3476
EAQ ATG ++DPV + R+ V A + G E++ L G+ DP + ++ Q
Sbjct: 3408 EAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQ 3467
Query: 3477 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLAD----P 3532
+++ + G+ +L Q+A G VH SEE+ L D P
Sbjct: 3468 LLRRCVPDPDTGLYML--QLAGRG--SAVHQ-------------LSEELRCALRDARVTP 3510
Query: 3533 SDDTKGFFDPNTHENLTYRQLLERCVED------------PETGLRLLPLKGAEKAEV-V 3579
+ E L YR++ E +D E G L L +A+
Sbjct: 3511 GSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARA 3570
Query: 3580 ETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGR 3639
E + R A +++ G G + +W+V+ S + R +L+A+F +G
Sbjct: 3571 EAEAGSPRPDPREALRAATMEVKVGRLR-GRAVPVWDVLASGYVSGAAREELLAEFGSGT 3629
Query: 3640 V---TKERMIIIIIEIIEKTEIIRQQ--------------GLASYDYVRRRL------TA 3676
+ R + IIE E+ R Q G D R +
Sbjct: 3630 LDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGET 3689
Query: 3677 EDLFEARIISLETYNLLREGTRSLREAL---EAESAWCYLYGTGSVAGVYLPGSR--QTL 3731
++ A + LR+ T ++ S W L+ + YL +R + L
Sbjct: 3690 QEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS------YLSEARRDELL 3743
Query: 3732 SIYQALKKGL--LSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE-LHD-- 3786
+ + A GL L A + R++ E + + +++ E G++GPE L D
Sbjct: 3744 AQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLA 3803
Query: 3787 ----------------RLLSAERAVTGYRDPYTEQ-----TISLFQAMKKELIPTEEALR 3825
R L + G P +Q +S++QAM K ++ AL
Sbjct: 3804 QGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALV 3863
Query: 3826 LLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQ-LSEPSEVRSYVDPSTDERLSY 3884
LL+AQ ATG ++DP L +E A G + + ++ LS V Y DP T +++S
Sbjct: 3864 LLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISL 3923
Query: 3885 TQLLRR 3890
Q +++
Sbjct: 3924 FQAMQK 3929
Score = 446 bits (1147), Expect = e-124
Identities = 449/1552 (28%), Positives = 699/1552 (45%), Gaps = 266/1552 (17%)
Query: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLE 2544
+ +E + LK+E T ++ +T QA+Q+ + + ++L R +E + A
Sbjct: 1960 VNEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEAL----RLLEVQVATGG 2015
Query: 2545 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
+ + +L E ++ + ++ L++ + R+R + + ELQ+
Sbjct: 2016 VI---DPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSYRELQERC 2072
Query: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----------- 2653
+ + +L N+ R+ + +E RA A E+T + K
Sbjct: 2073 RPQEDTGWVLFPVNKAARDSEHIDDETRRALEAEQVEITVGRFRGQKPTLWALLNSEYVT 2132
Query: 2654 ------------PNGRDALDGPA---------AEAEPEHS-FDGLRRKVSAQRLQEAGIL 2691
+ R AL A E +H F G+RR+++A L + I+
Sbjct: 2133 EEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAII 2192
Query: 2692 SAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN-----EKLSVYAALQRQ 2746
+ E LQ L G +T EL + V+ YL+G S IAG+L+ A + EK+S+Y A+ +
Sbjct: 2193 TEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKG 2252
Query: 2747 LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKD 2806
+L PGTAL+LLEAQAA+GF++DPVRN RL+V E V GVVG E+ KLLSAERAVTGY D
Sbjct: 2253 VLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTD 2312
Query: 2807 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM 2866
PYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM
Sbjct: 2313 PYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM 2372
Query: 2867 NRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDS 2926
NRVLADPSDDTKGFFDPNTHENLTY+QLL RCV DP+TGL +L L A +G +
Sbjct: 2373 NRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL---AGRGSAVHQLSE 2429
Query: 2927 EARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII 2986
E R A V+ G QG++V++WE++ + ++R+DLL ++R G +TVE++ +
Sbjct: 2430 ELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGATL 2489
Query: 2987 ITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRA 3046
+++ + + + R AE R RE + A ++
Sbjct: 2490 TSLLAQAQAQAR----------AEAEAGSPRPDPREALR-----------AATMEVKVGR 2528
Query: 3047 LRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLT-- 3104
LRG V VW A +S A +++LL A+ G+G + PA + RLT
Sbjct: 2529 LRGRAV--PVWDVLASGYVS--RAAREELL----------AEFGSGTLDLPALTRRLTAI 2574
Query: 3105 VDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQ 3164
++EA A P+ Q ++G PRE G
Sbjct: 2575 IEEAEEAPGARPQ--------------------------LQDARRG--PREPG------- 2599
Query: 3165 LSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQ 3224
+ G D +S R G + ET A +A A A T AT E+Q+
Sbjct: 2600 PAGRGDGDSGRSQR--------EGQGEGETQEAAAAA---AAARRQEQTLRDATM-EVQR 2647
Query: 3225 RCRPDQLTGLSLLPLSEKAARARQEELYSELQA------------RETFEKTPVEVPVGG 3272
+ + + S + AR++EL ++ A E+T +
Sbjct: 2648 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVS 2707
Query: 3273 FKG--RTVTVWELISSEYFTAEQRQELLRQFRT-GKVT-VEKVIKIL--------ITIVE 3320
F+G R V+ EL +S E ++L + +T +VT ++ V + L + +
Sbjct: 2708 FRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPA 2767
Query: 3321 EVETLRQERLS-----FSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV- 3374
+ + RQE++S + G+ P A LL + + + +++ + +V++ G V
Sbjct: 2768 KDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVG 2827
Query: 3375 ----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3430
LL + G T +++S+++AM++ L+ LLEAQ ATG ++DPV
Sbjct: 2828 GEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVH 2887
Query: 3431 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3490
+ R+ V A + G E++ L G+ DP + ++ Q +++ + G+
Sbjct: 2888 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLY 2947
Query: 3491 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLAD----PSDDTKGFFDPNTHE 3546
+L Q+A G VH SEE+ L D P + E
Sbjct: 2948 ML--QLAGRG--SAVHQ-------------LSEELRCALRDARVTPGSGALQGQSVSVWE 2990
Query: 3547 NLTYRQLLERCVED------------PETGLRLLPLKGAEKAEV-VETTQVYTEEETRRA 3593
L YR++ E +D E G L L +A+ E + R A
Sbjct: 2991 LLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREA 3050
Query: 3594 FEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRV---TKERMIIIII 3650
+++ G G + +W+V+ S + R +L+A+F +G + R + II
Sbjct: 3051 LRAATMEVKVGRLR-GRAVPVWDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAII 3109
Query: 3651 EIIEKTEIIRQQ--------------GLASYDYVRRRL------TAEDLFEARIISLETY 3690
E E+ R Q G D R + ++ A +
Sbjct: 3110 EEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQE 3169
Query: 3691 NLLREGTRSLREAL---EAESAWCYLYGTGSVAGVYLPGSR--QTLSIYQALKKGL--LS 3743
LR+ T ++ S W L+ + YL +R + L+ + A GL L
Sbjct: 3170 QTLRDATMEVQRGQFQGRPVSVWDVLFSS------YLSEARRDELLAQHAAGALGLPDLV 3223
Query: 3744 AEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE-LHD---------------- 3786
A + R++ E + + +++ E G++GPE L D
Sbjct: 3224 AVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDS 3283
Query: 3787 --RLLSAERAVTGYRDPYTEQ-----TISLFQAMKKELIPTEEALRLLDAQLATGGIVDP 3839
R L + G P +Q +S++QAM K ++ AL LL+AQ ATG ++DP
Sbjct: 3284 VKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDP 3343
Query: 3840 RLGFHLPLEVAYQRGYLNKDTHDQ-LSEPSEVRSYVDPSTDERLSYTQLLRR 3890
L +E A G + + ++ LS V Y DP T +++S Q +++
Sbjct: 3344 VRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQK 3395
Score = 350 bits (897), Expect = 2e-95
Identities = 286/925 (30%), Positives = 449/925 (48%), Gaps = 106/925 (11%)
Query: 2935 ATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQE 2994
AT+ G+FQG+ V++W+++ S Y + +R +LL Q G + + ++ ++ V+EE E
Sbjct: 4243 ATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETE 4302
Query: 2995 QK-GRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVI 3053
++ ++ F GLR V A+EL S ++ E + L +G +++++V E+D+V+R L G + I
Sbjct: 4303 ERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCI 4362
Query: 3054 AGVWLEEAGQ-----KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEA 3108
AGV + Q K+SIY A+ K +L A+ LLEAQA TG +IDP + RL+V+EA
Sbjct: 4363 AGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEA 4422
Query: 3109 VRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTG 3168
V AG+VG E EKLLSAE+AVTGY DPYTGQ +SLFQA++K LI RE G+RLL+AQ++TG
Sbjct: 4423 VAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATG 4482
Query: 3169 GIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRP 3228
G++DP SHRVP+DVA RG DEE +R L+ P D K + DP+T E TY +L +RC P
Sbjct: 4483 GVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVP 4542
Query: 3229 DQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEY 3288
D TGL +L L+ + + Q L EL+ V G +G++V+VWEL+
Sbjct: 4543 DPDTGLYMLQLAGRGSAVHQ--LSEELRC--ALRDARVTPGSGALQGQSVSVWELLFYRE 4598
Query: 3289 FTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG 3348
+ ++RQ+LL ++R G +TVE++ L +++ + + + +G P P L
Sbjct: 4599 VSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAE-AGSPRPDPREAL---- 4653
Query: 3349 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3408
RA ++K G+ L+G V +++ + G +
Sbjct: 4654 ---RAATMEVKVGR---------------LRGRA-------------VPVWDVLASGYVS 4682
Query: 3409 ATTAALLLEAQAATGFLVDPVRNQRL--YVHEAVKAGVVGPELHEQLLSA-EKAVTGYRD 3465
LL A+ +G L P +RL + EA +A P+L + E G D
Sbjct: 4683 GAAREELL-AEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGD 4741
Query: 3466 PYSGSTISLFQ---------AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAY 3516
SG + Q A ++ +R ++ G V V
Sbjct: 4742 GDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQF----QGRPVSVWDVL 4797
Query: 3517 QRGYFSE-EMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEK 3575
Y SE + +LA + G D +L R +E+ E L + +G +
Sbjct: 4798 FSSYLSEARRDELLAQHAAGALGLPD--------LVAVLTRVIEETEERLSKVSFRGLRR 4849
Query: 3576 AEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADF 3635
V ++++T ET D+ G T +L EV + D +
Sbjct: 4850 Q--VSASELHTSGILG---PETLRDLAQG------TKTLQEVTEMDSVK----------- 4887
Query: 3636 QAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDY----VRRRLTAEDLFEARIISLETYN 3691
R + I + + K + RQ+ ++ Y V R TA L EA+ + +
Sbjct: 4888 ---RYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVID 4944
Query: 3692 LLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3746
+R S+ EA+ A E L +V G P + Q +S++QA++K L+ E
Sbjct: 4945 PVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREH 5004
Query: 3747 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQT 3806
LLEAQ ATG ++DPV R+ VD A R+G E++ L G+ DP T +
Sbjct: 5005 GIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHEN 5064
Query: 3807 ISLFQAMKKELIPTEEALRLLDAQL 3831
++ Q +++ + E L L L
Sbjct: 5065 LTYLQLLQRATLDPETGLLFLSLSL 5089
Score = 347 bits (889), Expect = 2e-94
Identities = 202/360 (56%), Positives = 242/360 (67%), Gaps = 25/360 (6%)
Query: 2561 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620
+ +++ Q E E Q A+ ARR+ E+ +R E+Q+ + Q R +
Sbjct: 4746 RSQREGQGEGETQEAAAAAAAARRQ----EQTLRDATMEVQRGQFQGRPVSVWDVLFSSY 4801
Query: 2621 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP---EHSFDGLR 2677
L E A +E+ A A LP+ L E E + SF GLR
Sbjct: 4802 LSE-------------ARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 4848
Query: 2678 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN--- 2734
R+VSA L +GIL E L+ LAQG T+ E+ + V+ YL+G S IAG+L+ A +
Sbjct: 4849 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 4908
Query: 2735 --EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHH 2792
EK+S+Y A+ + +L PGTAL+LLEAQAA+GF++DPVRN RL+V EAV GVVG E+
Sbjct: 4909 RQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQE 4968
Query: 2793 KLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2852
KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVP
Sbjct: 4969 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVP 5028
Query: 2853 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLT 2912
VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLL+R DPETGL L L+
Sbjct: 5029 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLS 5088
Score = 254 bits (648), Expect = 2e-66
Identities = 137/307 (44%), Positives = 206/307 (67%), Gaps = 8/307 (2%)
Query: 3605 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3664
G G +S+W+V+ S + E +R +L+A AG + ++ ++ +IE+TE +
Sbjct: 4784 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETE--ERLSK 4841
Query: 3665 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3724
S+ +RR+++A +L + I+ ET L +GT++L+E E +S YL GT +AGV +
Sbjct: 4842 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4901
Query: 3725 P-----GSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGL 3779
P G ++ +SIYQA+ KG+L A +LLEAQAATGF++DPV+ RL+V+EAV G+
Sbjct: 4902 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4961
Query: 3780 VGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDP 3839
VG E+ ++LLSAERAVTGY DPYT Q ISLFQAM+K+LI E +RLL+AQ+ATGG++DP
Sbjct: 4962 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 5021
Query: 3840 RLGFHLPLEVAYQRGYLNKDTHDQLSEPS-EVRSYVDPSTDERLSYTQLLRRCRRDDGTG 3898
+P++VAY+RGY +++ + L++PS + + + DP+T E L+Y QLL+R D TG
Sbjct: 5022 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETG 5081
Query: 3899 QLLLPLS 3905
L L LS
Sbjct: 5082 LLFLSLS 5088
Score = 177 bits (449), Expect = 2e-43
Identities = 132/409 (32%), Positives = 206/409 (50%), Gaps = 15/409 (3%)
Query: 3050 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3109
A IAGV++E +GQ S+Y A+++ LLP+ + ALLEAQA TG ++D A L V +A+
Sbjct: 40 ARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKAL 99
Query: 3110 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3169
+ GLVG E EKLL+AE+A TGY DPY G+ ++LFQA+ K ++ R G L+ QL+TGG
Sbjct: 100 QQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGG 159
Query: 3170 IVDPSKSHRVPLDVACARGCLDEETSRALS--APRADAKAYSDPSTGEPATYGELQQRCR 3227
+VDP++ V + AC +G LD ET LS P + +P+T E TY +L +RC
Sbjct: 160 LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERCV 219
Query: 3228 PDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSE 3287
+GL+LLPL +EL ++ V+ G +GR V +E
Sbjct: 220 RAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQ---GLREGRLAAVDVSARAE 276
Query: 3288 YFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLAS 3347
+R++ G +V V+ + + E L G P+ ++
Sbjct: 277 ----------VRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATH 326
Query: 3348 GVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLL 3407
++ ++L + L LL + G + + ++ +++AM++GL+
Sbjct: 327 TLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLV 386
Query: 3408 RATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSA 3456
A LL+AQ ATG LV P R RL + A++ G + + QL A
Sbjct: 387 DRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQA 435
Score = 107 bits (267), Expect = 3e-22
Identities = 73/212 (34%), Positives = 111/212 (52%), Gaps = 5/212 (2%)
Query: 4292 TQLASWSDPTEETGPVAGIL-----DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG 4346
T++ S E T +AG+L EK+SI +AM + ++ T LLEAQA TG
Sbjct: 4347 TEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATG 4406
Query: 4347 GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWL 4406
+IDP R V +AV G+V + +++ A++A G+ DP T ++S QA++K +
Sbjct: 4407 FVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLI 4466
Query: 4407 YYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPK 4466
E G R LE Q TGG+I+P RVP+D A +RG D + L D +K P
Sbjct: 4467 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 4526
Query: 4467 TKLKISYKDALDRSMVEEGTGLRLLEAAAQST 4498
T ++Y L R + + TGL +L+ A + +
Sbjct: 4527 THENLTYVQLLRRCVPDPDTGLYMLQLAGRGS 4558
Score = 107 bits (266), Expect = 4e-22
Identities = 73/210 (34%), Positives = 109/210 (51%), Gaps = 5/210 (2%)
Query: 4292 TQLASWSDPTEETGPVAGIL-----DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG 4346
T++ S E T +AG+L EK+SI +AM + ++ T LLEAQA TG
Sbjct: 4881 TEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATG 4940
Query: 4347 GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWL 4406
+IDP R V +AV G+V + +++ A++A G+ DP T ++S QA++K +
Sbjct: 4941 FVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLI 5000
Query: 4407 YYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPK 4466
E G R LE Q TGG+I+P RVP+D A +RG D + L D +K P
Sbjct: 5001 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 5060
Query: 4467 TKLKISYKDALDRSMVEEGTGLRLLEAAAQ 4496
T ++Y L R+ ++ TGL L + Q
Sbjct: 5061 THENLTYLQLLQRATLDPETGLLFLSLSLQ 5090
Score = 105 bits (261), Expect = 1e-21
Identities = 69/217 (31%), Positives = 114/217 (52%), Gaps = 3/217 (1%)
Query: 4278 GSSSSYPIS-PAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQ 4336
G++S+ S P L + + P + +AG+ + + S+ AM + L+ GQ
Sbjct: 13 GTNSTEQASVPRAMAATLGAGTPPRPQARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQ 72
Query: 4337 RLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMS 4396
LLEAQA TGG++D + G+ PV+ A+ +GLV + +++ A++A G+ DP K++
Sbjct: 73 ALLEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATTGYPDPYGGEKLA 132
Query: 4397 AAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDV- 4455
QA+ K + GQ +LEVQ TGGL++P V + A +G +D T KL ++
Sbjct: 133 LFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSELE 192
Query: 4456 -GAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4491
G P T +++Y L+R + G+GL LL
Sbjct: 193 PGTGDLRFLNPNTLERLTYHQLLERCVRAPGSGLALL 229
Score = 70.5 bits (171), Expect = 4e-11
Identities = 61/227 (26%), Positives = 102/227 (44%), Gaps = 17/227 (7%)
Query: 3967 VDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPE 4026
++ T+ERLS + +G+ R +A EL + + + T++E M V
Sbjct: 4832 IEETEERLS--KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRY 4889
Query: 4027 FKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESH 4086
+ A V P + +S++QAM KG++ + LLEAQ ATG +IDP +
Sbjct: 4890 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 4949
Query: 4087 RLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLL 4146
RL VE A G+ E+ E L G+ DP T + ++ Q M++ + + G+ LL
Sbjct: 4950 RLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 5009
Query: 4147 PLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQ 4193
E + ++ ++DP + V AYR+G D +
Sbjct: 5010 -------EAQIATGG--------VIDPVHSHRVPVDVAYRRGYFDEE 5041
Score = 60.8 bits (146), Expect = 3e-08
Identities = 32/119 (26%), Positives = 61/119 (51%)
Query: 2719 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2778
L ++ G T +++S++ A+Q+ L+ + LLEAQ A+G ++DPV + R+ V+
Sbjct: 4971 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 5030
Query: 2779 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2837
A + G E++ L G+ DP T + ++ Q +Q+ + E G+ L +
Sbjct: 5031 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089
Score = 47.0 bits (110), Expect = 4e-04
Identities = 37/167 (22%), Positives = 73/167 (43%)
Query: 4310 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4369
++D ++S+ EA+ +V ++LL A+ G DP TG++ + A+ K L+
Sbjct: 4408 VIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIV 4467
Query: 4370 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4429
+ R+ AQ A G DP ++ A ++G+ E + + T G +P+T
Sbjct: 4468 REHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNT 4527
Query: 4430 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDA 4476
+ + L+R D T + + + +L+ + +DA
Sbjct: 4528 HENLTYVQLLRRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDA 4574
>gi|58530842 desmoplakin isoform II [Homo sapiens]
Length = 2272
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 3667 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3726
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
Query: 3727 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3786
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
Query: 3787 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3846
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
Query: 3847 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3905
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
Query: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
Query: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
Query: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
Query: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
Query: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
Query: 4206 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4265
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
Query: 4266 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4311
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
Query: 4312 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4371
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
Query: 4372 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4431
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
Query: 4432 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4491
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
Query: 4492 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4543
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
Query: 4544 FSSSS 4548
FSSSS
Sbjct: 2265 FSSSS 2269
Score = 597 bits (1538), Expect = e-169
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 435 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 494
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
Query: 495 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 551
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
Query: 552 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 611
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
Query: 612 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 671
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
Query: 672 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 731
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
Query: 732 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 791
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
Query: 792 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 851
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
Query: 852 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 911
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
Query: 912 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 971
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
Query: 972 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1011
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
Query: 1012 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1061
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
Query: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
Query: 1122 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1181
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
Query: 1182 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1241
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
Query: 1242 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1301
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
Query: 1302 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
Query: 1361 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1418
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
Query: 1419 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
Query: 1479 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1538
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
Query: 1539 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1598
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
Query: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1657
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
Query: 1658 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1717
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
Query: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1772
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
Query: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1824
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
Query: 1825 ELAEEAARLRALAEEAKRQRQLAEEDA 1851
+L ++A R L + RQ+ A E A
Sbjct: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 2963 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3018
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
Query: 3019 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3075
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
Query: 3076 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3135
A+ L E Q +D + +V+E V E L A P
Sbjct: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
Query: 3136 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3195
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
Query: 3196 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3239
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
Query: 3240 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3296
+ A AR +LY L +K V+ PV K V + E
Sbjct: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
Query: 3297 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3356
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
Query: 3357 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3416
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
Query: 3417 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3476
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
Query: 3477 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3536
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
Query: 3537 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3596
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
Query: 3597 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3648
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
Query: 3649 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3679
I + I+K + R + G S ++ ++D+
Sbjct: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
Query: 3680 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3732
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
Query: 3733 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3792
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
Query: 3793 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3852
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
Query: 3853 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3911
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
Query: 3912 FRGLRKQITM 3921
+GL M
Sbjct: 2211 SKGLPSPYNM 2220
Score = 417 bits (1072), Expect = e-115
Identities = 363/1343 (27%), Positives = 649/1343 (48%), Gaps = 181/1343 (13%)
Query: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
Query: 2332 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2391
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
Query: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
Query: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2511
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
Query: 2512 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2571
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
Query: 2572 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
Query: 2632 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2677
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
Query: 2678 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2737
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
Query: 2738 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2797
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
Query: 2798 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2857
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
Query: 2858 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2917
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
Query: 2918 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2975
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
Query: 2976 RITVEKIIKII---------ITVVEEQEQKGRL-CFEGLR-SLV---PAAELLESR---- 3017
+I+ +++ + I I + + K +L +E ++ LV A ELLE++
Sbjct: 1641 QISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATG 1700
Query: 3018 -VIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLL 3076
++D +L E R + ++ + L + G E G +S++ A+ K+L+
Sbjct: 1701 FIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELI 1760
Query: 3077 PSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPY 3136
+ LLEAQ TG IIDP S RL VD A + G E E L G+ DP
Sbjct: 1761 EKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPN 1820
Query: 3137 TGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSR 3196
T ++++ Q ++ + E GL LL + + K+ V +D ET++
Sbjct: 1821 TEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV----IVDPETNK 1876
Query: 3197 ALSAPRADAKAYSDPSTGEPATYGEL-QQRCRPDQLTGLSLLPLSEKAARARQEELYSEL 3255
+S A K D T+ EL +Q C +++T + S+ + R L
Sbjct: 1877 EMSVQEAYKKGLIDYE-----TFKELCEQECEWEEIT----ITGSDGSTRV-------VL 1920
Query: 3256 QARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKIL 3315
R+T + ++ + KG L+ ++F Q+R+G +++ + ++
Sbjct: 1921 VDRKTGSQYDIQDAID--KG-------LVDRKFFD---------QYRSGSLSLTQFADMI 1962
Query: 3316 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3375
L+ V S + SGV S F + +V +S + SVR
Sbjct: 1963 ------------------SLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSVR 2001
Query: 3376 TL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFL 3425
L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG +
Sbjct: 2002 NLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGI 2061
Query: 3426 VDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLR 3485
+ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 2062 IHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPY 2121
Query: 3486 QHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTH 3545
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 2122 EAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTK 2181
Query: 3546 ENLTYRQLLERCVEDPETGLRLL 3568
++Y+ + R + + TGLRLL
Sbjct: 2182 LKISYKDAINRSMVEDITGLRLL 2204
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 2672 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2731
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
Query: 2732 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2791
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
Query: 2792 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2851
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
Query: 2852 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2911
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
Query: 2912 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2955
+K + +V D E ++ ++K + K + WE I
Sbjct: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
Query: 2956 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 3007
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
Query: 3008 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3057
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
Query: 3058 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3117
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
Query: 3118 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3177
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
Query: 3178 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3237
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
Query: 3238 PLSEKAAR 3245
+ +++
Sbjct: 2205 EAASVSSK 2212
Score = 259 bits (663), Expect = 3e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
Query: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
Query: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
Query: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
Query: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
Query: 4206 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4261
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
Query: 4262 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4318
+L A GF S+ P+ A R + V G D ET
Sbjct: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
Query: 4319 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4378
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
Query: 4379 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4423
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
Query: 4424 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4470
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
Query: 4471 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4530
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
Query: 4531 GS---FDATGSGFSMTFSSSSYSSS 4552
S S ++T SSS+S +
Sbjct: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
Score = 111 bits (278), Expect = 1e-23
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1799
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
Query: 1800 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1856
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
Query: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
Query: 1917 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
Query: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
Query: 2034 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
Query: 2090 QELQQTLQQEQSVLDQLRGEAEA 2112
E + T+ + V D LR + A
Sbjct: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
Score = 99.8 bits (247), Expect = 6e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2719 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2778
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
Query: 2779 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2838
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
Query: 2839 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2898
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
Query: 2899 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2928
+ + TGL LL ++KG Y S A
Sbjct: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 3667 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3726
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
Query: 3727 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3786
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
Query: 3787 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3846
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
Query: 3847 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3905
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
Query: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
Query: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
Query: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
Query: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
Query: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
Query: 4206 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4265
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
Query: 4266 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4311
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
Query: 4312 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4371
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
Query: 4372 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4431
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
Query: 4432 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4491
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
Query: 4492 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4543
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
Query: 4544 FSSSS 4548
FSSSS
Sbjct: 2864 FSSSS 2868
Score = 862 bits (2228), Expect = 0.0
Identities = 745/2950 (25%), Positives = 1363/2950 (46%), Gaps = 355/2950 (12%)
Query: 435 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 494
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
Query: 495 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 551
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
Query: 552 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 611
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
Query: 612 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 671
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
Query: 672 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 731
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
Query: 732 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 791
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
Query: 792 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 851
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
Query: 852 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 911
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
Query: 912 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 971
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
Query: 972 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1011
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
Query: 1012 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1061
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
Query: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
Query: 1122 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1181
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
Query: 1182 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1241
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
Query: 1242 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1301
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
Query: 1302 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
Query: 1361 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1406
+F+SE L+ +EEE RLA +E + ++ L+K Q + ++
Sbjct: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
Query: 1407 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1450
A + K QAE + K +Q + E++ R D +++++S+++
Sbjct: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
Query: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1510
Q Q ++ + KARQ E +E + +L+ E +++ E E++ LR +
Sbjct: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
Query: 1511 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567
E +KR+ + E ++R +E + K + E+ + E +E +
Sbjct: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
Query: 1568 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1622
LR Q + R R + E R + A E +R+ E LQ K + +K LE
Sbjct: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
Query: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1681
L++ + Q E+ R Q EA + ++ +E+ER + + E + R + E E+++
Sbjct: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
Query: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
++ E K + E E Q Q+ E++ R + ++ + +E
Sbjct: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
Query: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801
+ RL+ Q + + +EE++ + + + +Q++Q+LE EL +V ++ R
Sbjct: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
Query: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1860
EE S + KQ L+ A ++ +E RL+ L ++ R+ E++ AR QR + +
Sbjct: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
Query: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1920
+ +A TE LK +E E RLR E + +R ++ + + ++E
Sbjct: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
Query: 1921 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1977
Q +K + EL R K + +R+++EEE+ ++ S ++ A L +L +
Sbjct: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
Query: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 2030
++ +ED LR + R++Q EE RR E +++ L E+E+ +Q
Sbjct: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
Query: 2031 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
+KA ++ L E RL+ E + L L +E RL+ ++ + +
Sbjct: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
Query: 2090 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137
+ EL+ LQ + Q +++ L+ E E R+ E+ ++ ++A +S+ Q
Sbjct: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
Query: 2138 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2197
+ + ++S + + Q +A ++L E E R +A R KQ + E ++
Sbjct: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
Query: 2198 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2256
+ Q Q ++ E+ + + + E+++ +KN L E++RL+AE R R ++E+
Sbjct: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
Query: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2313
S R +L ++R + E L R + R Q E E ++ + R V
Sbjct: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
Query: 2314 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2373
A QL E L + L +K+LK K
Sbjct: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
Query: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2433
+ +++A E Q F R + + ++ + + K + E R + + E
Sbjct: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
Query: 2434 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2491
+ G + HR E T + ++ +Q + AE+ + K
Sbjct: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
Query: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
EA L E L E Q + +S+ F+ ++ A L ++
Sbjct: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
Query: 2552 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2611
++ L + + Q+ ++ ++ V+ ++ R + E G L L Q+R
Sbjct: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
Query: 2612 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2669
Q +R+ + + E L S E+ + Q++ + +D L G + A
Sbjct: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
Query: 2670 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2729
G+ + + Q+L GI A ++ + G T EL L+ +++ ++
Sbjct: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
Query: 2730 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2789
+N +L V A +R L+ LL A+ A DP +++ +A+ + ++
Sbjct: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
Query: 2790 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2849
+LL A+ A G DP ++ + A ++G
Sbjct: 2363 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG--------------------------- 2395
Query: 2850 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2909
YF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2396 -----------YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
Query: 2910 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2953
PL +K + +V D E ++ ++K + K + WE
Sbjct: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
Query: 2954 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 3005
I R L+ + + ++ I ++ +Q + G L L+
Sbjct: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
Query: 3006 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3055
+ V + + S V D +++ + SV ++ + +VR L ++ IA
Sbjct: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
Query: 3056 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3115
++ E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++
Sbjct: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
Query: 3116 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3175
+ +L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
Query: 3176 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3235
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL
Sbjct: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
Query: 3236 LLPLSEKAAR 3245
LL + +++
Sbjct: 2802 LLEAASVSSK 2811
Score = 544 bits (1401), Expect = e-154
Identities = 502/1978 (25%), Positives = 899/1978 (45%), Gaps = 304/1978 (15%)
Query: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1799
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
Query: 1800 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1856
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
Query: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+ +
Sbjct: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
Query: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
E ++ LR ++E+ K +++ Q+ E++ L+ ++ + +L+ E+
Sbjct: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
Query: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
R+ + + +AE A +Q+ +E ++++ E +++ + E + K +LE
Sbjct: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
Query: 2037 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2080
E + ++ K +E RL+ ++E+ R+ + E ++ R +E+
Sbjct: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
Query: 2081 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2114
H +Q++E + L+ TL Q L ++ + + +
Sbjct: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
Query: 2115 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
E + + Q E E Q ++ + EE+ R KQS ++ A+ E+L++ ++E
Sbjct: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
Query: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
R E R Q +++K A +T+ + EQELT LR+ E ++ + D
Sbjct: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
Query: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293
+++ R + E Q+ +VEEEL ++ E S + ++E E + +R L
Sbjct: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
Query: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
+E+A K+ + ++ + S+ +++ +E+DL QQR + + L+EK + +E RL
Sbjct: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
Query: 2354 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413
+E E L++Q L QEQ + +Q + FQ+ +E + + E E ERL+
Sbjct: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
Query: 2414 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2473
+++ EE+ + R + +++ + R+E + + T+++ L Q Q S++
Sbjct: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
Query: 2474 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2533
L+ I +L+RE+E L+QE + Q ++ E QE Q TQ +Q E++SLL +
Sbjct: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
Query: 2534 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
+ +EQ+KA+L++L +DE+ +A+ E + R +Q++E E+Q++ + + + + EE +
Sbjct: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
Query: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2653
R+ + E ++ E+++ L E +RL+ +++ +EE+ R L S T SQ+
Sbjct: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL------ 1928
Query: 2654 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2713
E E S R + +L++ S E Q + TVD
Sbjct: 1929 --------------ETERS----RYQREIDKLRQRPYGSHRETQ--TECEWTVD------ 1962
Query: 2714 DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNR 2773
KL V+ L++++ TA+ L E Q LD +
Sbjct: 1963 --------------------TSKL-VFDGLRKKV----TAMQLYECQLIDKTTLDKLLKG 1997
Query: 2774 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLL 2833
+ +V E V E+ L A P ++ SL +A +K LI E + LL
Sbjct: 1998 KKSVEE------VASEIQPFLRGAGSIAGASASPK--EKYSLVEAKRKKLISPESTVMLL 2049
Query: 2834 EAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQ 2893
EAQ ATGG+IDP + ++ VD A R D + + + GF DP + + ++ +
Sbjct: 2050 EAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSE 2109
Query: 2894 LLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWE 2953
+++ + D ETG+ LL + A GG + +S VF V+ G
Sbjct: 2110 AIKKNLIDRETGMRLLEA--QIASGGVVDPVNS----VFLPKDVALARGL---------- 2153
Query: 2954 IINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQE---------------QKGR 2998
I Y + RD + F V+ + K ++ V+ +E QK
Sbjct: 2154 IDRDLYRSLNDPRDSQKNF------VDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRS 2207
Query: 2999 LCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWL 3058
+ F+G+R V EL++S ++ +L+ G+ S +V E ++ L+G++ IAG++
Sbjct: 2208 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE--RIKDFLQGSSCIAGIYN 2265
Query: 3059 EEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEF 3118
E QKL IY A+K L+ A+ LLEAQA TG I+DP ++ RL V+EA + GLVG EF
Sbjct: 2266 ETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEF 2325
Query: 3119 HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHR 3178
EKLLSAE+AVTGY DP TG +SLFQA+ K LI + G+RLL+AQ++TGGI+DP +SHR
Sbjct: 2326 KEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHR 2385
Query: 3179 VPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP 3238
+P+D+A RG +EE S LS P D K + DP+T E TY +L++RC D+ TGL LLP
Sbjct: 2386 LPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLP 2445
Query: 3239 LSEKAARARQE---------------ELYSELQARETFEKTPV----------------E 3267
L EK + + E E+ +E ++K + E
Sbjct: 2446 LKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEE 2505
Query: 3268 VPVGGFKG--RTVTVWELISSEYFTAEQ------RQELLRQFRTGKVTVEKVIKIL---- 3315
+ + G G R V V S+Y + ++ Q+R+G +++ + ++
Sbjct: 2506 ITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKN 2565
Query: 3316 ------------------------ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLS 3351
++ + + ++R + S + S +A+ +
Sbjct: 2566 GVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA-IFD 2624
Query: 3352 RAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATT 3411
E++ + + + + + + LL+ C GI T +K+S+ +A+ +G++
Sbjct: 2625 TENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDM 2684
Query: 3412 AALLLEAQAA--------------------------------------TGFLVDPVRNQR 3433
A L AQ A TG LVDP + R
Sbjct: 2685 ATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGR 2744
Query: 3434 LYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLE 3493
+ EA++ G + ++L P + IS A+ + +V G+RLLE
Sbjct: 2745 ISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLE 2804
Query: 3494 -AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3550
A +++ G+ P + P + R S +G FD + + +Y
Sbjct: 2805 AASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSFDATGNSSYSY 2860
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 2963 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3018
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
Query: 3019 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3075
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
Query: 3076 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3135
A+ L E Q +D + +V+E V E L A P
Sbjct: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
Query: 3136 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3195
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
Query: 3196 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3239
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
Query: 3240 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3296
+ A AR +LY L +K V+ PV K V + E
Sbjct: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
Query: 3297 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3356
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
Query: 3357 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3416
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
Query: 3417 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3476
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
Query: 3477 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3536
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
Query: 3537 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3596
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
Query: 3597 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3648
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
Query: 3649 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3679
I + I+K + R + G S ++ ++D+
Sbjct: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
Query: 3680 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3732
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
Query: 3733 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3792
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
Query: 3793 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3852
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
Query: 3853 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3911
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
Query: 3912 FRGLRKQITM 3921
+GL M
Sbjct: 2810 SKGLPSPYNM 2819
Score = 259 bits (663), Expect = 3e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
Query: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
Query: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
Query: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
Query: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
Query: 4206 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4261
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
Query: 4262 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4318
+L A GF S+ P+ A R + V G D ET
Sbjct: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
Query: 4319 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4378
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
Query: 4379 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4423
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
Query: 4424 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4470
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
Query: 4471 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4530
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
Query: 4531 GS---FDATGSGFSMTFSSSSYSSS 4552
S S ++T SSS+S +
Sbjct: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 921 bits (2380), Expect = 0.0
Identities = 596/2064 (28%), Positives = 1094/2064 (53%), Gaps = 117/2064 (5%)
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
Query: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106
Query: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1442
+++ ++ +E A + ++A L+ ++ ++ E + ++QK
Sbjct: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154
Query: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502
++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL
Sbjct: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214
Query: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562
+ +R EAEA++ +E R Q+++ + +R E L + + + ++K + +
Sbjct: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274
Query: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622
+ L R EE + ++Q E + A Q QVA + + + EL+++R K +++ +
Sbjct: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329
Query: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1682
+E + V + + RA + E +++AE EL++ + +E +AE+ ++
Sbjct: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385
Query: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742
+ + +K +E +AR ++ + ELE++ Q +G +QQ ++L
Sbjct: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
Query: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802
+ + E+ Q+ L++ Q E + ++ +L+ E+ ++
Sbjct: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490
Query: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1860
+ + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+
Sbjct: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
Query: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1917
+K+ + E E LK+K E L R + +R++ E K
Sbjct: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606
Query: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
I++R L+ +D + Q + L ++ + E++ E+ A L E +
Sbjct: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664
Query: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2037
+ + ++ + + E+ A++EE+RR E + ++Q +A ++E
Sbjct: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711
Query: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2097
+ KV++ L+ EQ + R++ L QE + K Q+ E+ ++K ++L ++
Sbjct: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEE-----FRKKMEKLMESKV 1766
Query: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157
++ + +R + + ++ A+E E + RQ L+Q E+ Q +
Sbjct: 1767 ITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQ------LQQYREQMQQGQHM 1820
Query: 2158 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT- 2216
+K +K ++ A++ + E L+QK + +H+ Q QK ++ T
Sbjct: 1821 EANHYQKCQKLEDELIAQKREVEN--LKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTF 1878
Query: 2217 --TLRLQLEETDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLK 2271
+ ++E H L L Q Q EE + RV +E++ K +
Sbjct: 1879 KPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRV-VEQIPK-E 1936
Query: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
+ + L +K+ +Q+ E ++ + L + E + +L+E + +
Sbjct: 1937 VQFQPPGAPL---EKEKSQQCYSE------YFSQTSTELQITFDETNPITRLSEIEKIRD 1987
Query: 2332 RALAEKMLKEKMQ---AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2388
+AL + Q E ++ E+ + ++ + L+++K +
Sbjct: 1988 QALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWML 2047
Query: 2389 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA---EEIGEKLH 2445
+G + + ++ L+ E E + + + + E Q R + + KL
Sbjct: 2048 EGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLL 2107
Query: 2446 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA--------KLLQ 2497
Q ++ L E+Q+ + + A LE KEK+ + K++
Sbjct: 2108 DMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVA 2167
Query: 2498 LKSEEMQTVQQ---EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554
L E Q + + +T +++ + L R R +E EKA + + +
Sbjct: 2168 LAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSYSSKTLSV 2227
Query: 2555 QQLREEQQRQQQQMEQERQRLVAS 2578
Q E + +Q+ + + +AS
Sbjct: 2228 FQAMENRMLDRQKGKHILEAQIAS 2251
Score = 414 bits (1064), Expect = e-114
Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)
Query: 3846 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3897
PLE+A + Y D H +++ + ++ V PS +E +L CR G
Sbjct: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064
Query: 3898 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3946
G + D + F+GLR +T +LV ++++D T QLR GL ++E
Sbjct: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123
Query: 3947 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 4006
EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP
Sbjct: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183
Query: 4007 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4066
I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G
Sbjct: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241
Query: 4067 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4126
+LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L
Sbjct: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301
Query: 4127 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4186
Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++
Sbjct: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357
Query: 4187 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4246
+ LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ +
Sbjct: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417
Query: 4247 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4306
+Y+ G +++TE AD L +S V + L S P
Sbjct: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447
Query: 4307 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4366
VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G
Sbjct: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507
Query: 4367 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4426
LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE
Sbjct: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567
Query: 4427 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4486
P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T
Sbjct: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627
Query: 4487 GLRLLEAAAQSTKGYYSPY 4505
GL+LLE + G S Y
Sbjct: 2628 GLKLLEVSEPLMTGISSLY 2646
Score = 411 bits (1056), Expect = e-114
Identities = 537/2416 (22%), Positives = 1013/2416 (41%), Gaps = 334/2416 (13%)
Query: 1065 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1124
K V R E E +L E + + + L+LT E++ L + Y + L T R
Sbjct: 316 KNVHRAIEEFES--SLKEAKISEIQMTAPLKLTYA--EKLHRLESQYAKLLNTSRNQERH 371
Query: 1125 TQGAEE-VLRAHEEQL----KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1179
V RA E + KE + V E A K A+ + D +
Sbjct: 372 LDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRE---LDQKEEN 428
Query: 1180 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1239
++ QE+ E+L + + +E +R A + +W +L ++ +++ ++
Sbjct: 429 IKSVQEIAEQLLLENHPARLTIEAYR---AAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
Query: 1240 ---RESADPLGAWLQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIERH 1288
+E+ D L L+DA +R+ + +S +E+L Q ++ + +
Sbjct: 486 NDAKEATDYLRN-LKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGK 544
Query: 1289 GEKV-------EECQRFAKQYINAIKDY-ELQLVTYKAQLEPVASPAKKPKVQ----SGS 1336
+ + +C I AI DY ++++ YK +A+ + + K + +G+
Sbjct: 545 AKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGN 604
Query: 1337 ESVI-----------QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1385
E+++ +E VDL + QY + + + E + +
Sbjct: 605 EAMVPSVCFTVPPPNKEAVDLANRIEQ------QY-----QNVLTLWHESHINMKSVVSW 653
Query: 1386 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445
+ E++ + +A + ++ LQ R ++ + +E+ V + +
Sbjct: 654 HYLINEIDRI--RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQL 711
Query: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
++E+ +Q + +++ R+ + L I E +R +RL+LE E + ++ +
Sbjct: 712 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISE-VRNIRLRLENCEDRL------IRQI 764
Query: 1506 RARAEEAEAQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
R E + + + E E+L++++ E + + AA L++
Sbjct: 765 RTPLERDDLHESVFRITEQEKLKKEL--ERLKDDLGTITNKCEEFFSQAAASSSVPTLRS 822
Query: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
+ LQ + +++ + V + L+ Q +AEA ++ E+ A +
Sbjct: 823 ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQ-AAEALVKLYETKLCEEEAVIADKNN 881
Query: 1625 EEHV--AVAQLREEAERRAQ---------QQAEA----------------ERAREEAERE 1657
E++ + Q R E + + Q Q+A+A + +E+A++
Sbjct: 882 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941
Query: 1658 LERWQ---------LKANEALRLRLQ--------AEEVAQQKSLAQAEAEKQKEEAEREA 1700
+ERWQ L+ E + L+ ++ QQ Q + ++ + E +
Sbjct: 942 VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1001
Query: 1701 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760
+ ++ V + E+ + ++++ ++ AE + E + + RA + QQ+ ++
Sbjct: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDS--QQKSPVK 1059
Query: 1761 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SKARAEEES----RSTSEKS 1812
R+Q A Q+ +L + M + S R EEE + TSE
Sbjct: 1060 RR--RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHG 1117
Query: 1813 K-----QRLEAEA-------GRFRELAEEAARLRA----LAEEAKRQRQLAEEDAARQRA 1856
QR +A G+ EL A L+ + EE + R+ AE + +Q+
Sbjct: 1118 AYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177
Query: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQ 1913
E + +K+ A EA + + E E ++EKEA E ER+R+L + +R +EE
Sbjct: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
Query: 1914 HKADIEERLAQLRKASD---------SELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964
+ +EE R D ++LE+QK + + LR++R EEE+L L EK
Sbjct: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKD 1297
Query: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024
A + ++ AE L+ K++ ELEA R+ R + ++ +
Sbjct: 1298 LAFQKQV----------AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCR 1347
Query: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAF 2083
Q++ ++ E LK +V+E +AEQ+ R+L A Q ++ +EEKA
Sbjct: 1348 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM-RELTYELNALQLEKTSSEEKARLL 1406
Query: 2084 AVQQKEQ---------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
+ E EL++ Q E+ QLR + +AEEA +A
Sbjct: 1407 KDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK 1466
Query: 2135 RRQVEEAERL---KQSAEEQAQARAQAQAAAEK-----------LRKEAEQEAARRAQAE 2180
R E E L K + + +A A AEK R E E E + Q +
Sbjct: 1467 RNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRK 1526
Query: 2181 QAALRQK---------QAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKN 2230
L+++ Q AE E + K Q L ++ + E L+ ++EE Q N
Sbjct: 1527 SDHLKEQFEKSHEQLLQNIKAEKENNDKI--QRLNEELEKSNECAEMLKQKVEELTRQNN 1584
Query: 2231 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-----------EELSKLKARIEAENR 2279
+QR++AE+ ++ +++ ++++Q E L K + R
Sbjct: 1585 ETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQR 1644
Query: 2280 ALILRDKD--NTQRFLQEEAEKMKQ-------VAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
+ ++D +Q + E +K Q +E L+ + ++ E+ +
Sbjct: 1645 KIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQL 1704
Query: 2331 QRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQEDKEQMAQQLAE--- 2386
Q+A ++ L +++ VQ+ LK E ++ ++ L QE++ + ++ E+ +++ +
Sbjct: 1705 QQAQVQE-LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLME 1763
Query: 2387 -------ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
+ G + + +Q A+ + + E+ R + E Q+ +
Sbjct: 1764 SKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEAN 1823
Query: 2440 IGEKLHRTE---LATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKE-------- 2487
+K + E +A + +V L Q ++ Q ++ +H L+ I + K+
Sbjct: 1824 HYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFE 1883
Query: 2488 ----KLQQEAKLLQLKSEEMQTVQQEQLL---QETQALQQSFLSEKDSLLQRERFIEQEK 2540
+ Q +L + + + LL QE Q L++ + + +E +
Sbjct: 1884 MTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPG 1943
Query: 2541 AKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR--- 2594
A LE+ K+QQ E Q + Q+ + + + E + + +A R
Sbjct: 1944 APLEK------EKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPV 1997
Query: 2595 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654
R Q+ ++E + +A+ Q +Q + + +EE A+ L
Sbjct: 1998 RYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLK 2057
Query: 2655 NGRDALDGPAAEA-------------EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701
G G E + E F GLR V+A++L EA +L +++L
Sbjct: 2058 KGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRL 2117
Query: 2702 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2761
G TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQA
Sbjct: 2118 GLKTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQA 2175
Query: 2762 ASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2821
A+GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+
Sbjct: 2176 ATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMEN 2233
Query: 2822 GLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFF 2881
++ R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F
Sbjct: 2234 RMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFP 2293
Query: 2882 DPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPF 2941
+PN + L Y +LL CV D E+ L P GE ++ + + V
Sbjct: 2294 NPNNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK- 2345
Query: 2942 GKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCF 3001
G +T++E R +EK I + ++ ++ + K + F
Sbjct: 2346 ---TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFF 2382
Query: 3002 E--------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRAL 3047
E GL + E +E ID+ L ++ Q G ++ ++A+ R
Sbjct: 2383 ESYGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVP 2440
Query: 3048 RG--ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTV 3105
+ + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V
Sbjct: 2441 KKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRV 2500
Query: 3106 DEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3165
EA+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q
Sbjct: 2501 AEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQY 2560
Query: 3166 STGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQR 3225
TGG+++P R+ ++ A G +D + L ++ + P T TY E ++
Sbjct: 2561 LTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEK 2620
Query: 3226 CRPDQLTGLSLLPLSE 3241
D TGL LL +SE
Sbjct: 2621 ADFDFHTGLKLLEVSE 2636
Score = 262 bits (669), Expect = 7e-69
Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)
Query: 3324 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3383
++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L +
Sbjct: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138
Query: 3384 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3443
+AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G
Sbjct: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198
Query: 3444 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3503
VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID
Sbjct: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256
Query: 3504 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3563
PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+
Sbjct: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316
Query: 3564 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3621
L P + V +T ++ + + GS ++++E Q +
Sbjct: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359
Query: 3622 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3680
LI + +L +Q KE M + GL +
Sbjct: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407
Query: 3681 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3736
E I +EG +L E A+S L VAG +L S + +S+ +A
Sbjct: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465
Query: 3737 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3796
++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T
Sbjct: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525
Query: 3797 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3856
G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G +
Sbjct: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585
Query: 3857 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3906
+ +L + S VR+ + P T +L+Y + L + D TG LL +S+
Sbjct: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636
Score = 260 bits (664), Expect = 3e-68
Identities = 169/550 (30%), Positives = 284/550 (51%), Gaps = 74/550 (13%)
Query: 3670 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3729
+R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++
Sbjct: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149
Query: 3730 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3789
+S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL
Sbjct: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209
Query: 3790 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3849
AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+
Sbjct: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267
Query: 3850 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3908
A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R
Sbjct: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326
Query: 3909 KLTFRGLRK-------------QITMEELVRSQVMDEATALQL----------------- 3938
++ ++K ++T+ E + +++++ L+L
Sbjct: 2327 NISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYG 2386
Query: 3939 ----------------------------------REGLTSIEEVTKNLQKFL----EGTS 3960
+EGL ++ E+ +L L + S
Sbjct: 2387 HSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHS 2446
Query: 3961 CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM 4020
+AG ++ A+ ER+SV +A ++ ++ TA LEAQ +TG +IDP+ G K V EA+
Sbjct: 2447 PVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHR 2506
Query: 4021 GIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGII 4080
G+V F +L E +TG P + K++S+ +A+ +I K+ GIR LE Q TGG+I
Sbjct: 2507 GLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLI 2566
Query: 4081 DPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQ 4140
+P+ RL +E A + G+ D + L D + P T+ LTY + +E+ D
Sbjct: 2567 EPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFH 2626
Query: 4141 TGLCLLPLKE 4150
TGL LL + E
Sbjct: 2627 TGLKLLEVSE 2636
Score = 206 bits (525), Expect = 3e-52
Identities = 161/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)
Query: 3001 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3060
F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE
Sbjct: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146
Query: 3061 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3120
+K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF
Sbjct: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206
Query: 3121 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3180
+LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP
Sbjct: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264
Query: 3181 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3240
++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P
Sbjct: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324
Query: 3241 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3283
E+ + SEL E F++ +E + ++ + +E
Sbjct: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384
Query: 3284 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3335
SS T + E + Q K V+K + LIT+ E ++L + L
Sbjct: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444
Query: 3336 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3395
+PV L ASG E++ K + ++L + + L+ GI T +K
Sbjct: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497
Query: 3396 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3455
+ EA+ RGL+ A L + + + P+ N+ + V EAV A ++ E+ + L
Sbjct: 2498 YRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLE 2557
Query: 3456 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3515
+ G +P S +S+ +A+Q G++ + IAT
Sbjct: 2558 FQYLTGGLIEPQVHSRLSIEEALQVGII---------DVLIAT----------------- 2591
Query: 3516 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3568
L D + P T LTY++ LE+ D TGL+LL
Sbjct: 2592 ------------KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632
Score = 114 bits (284), Expect = 3e-24
Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)
Query: 2687 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2744
E G + +++ +G T+ ELA R + S +AG L A+ E++SV A +
Sbjct: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467
Query: 2745 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2804
R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG
Sbjct: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527
Query: 2805 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2864
P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D
Sbjct: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587
Query: 2865 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2924
+ L D + P T LTY + LE+ D TGL LL +++ G +Y
Sbjct: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647
Query: 2925 DS 2926
S
Sbjct: 2648 SS 2649
Score = 64.3 bits (155), Expect = 3e-09
Identities = 34/98 (34%), Positives = 61/98 (62%)
Query: 417 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 476
RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 477 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 514
R DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 861 bits (2224), Expect = 0.0
Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 630 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 689
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 690 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 750 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 809
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 810 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 869
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 870 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 929
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 930 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 989
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 990 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1049
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 1050 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1109
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 1110 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1169
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1170 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1229
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1230 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1289
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1290 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1349
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1350 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1409
Query: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1410 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1469
Query: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1470 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1522
Query: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1483
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1523 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1581
Query: 1484 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1582 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1639
Query: 1534 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1591
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1640 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1699
Query: 1592 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1647
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1700 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1759
Query: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1697
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1760 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1818
Query: 1698 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1752
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1819 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1878
Query: 1753 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1879 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1938
Query: 1807 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1852
S S++ +++ A R+L R R+L + + L + EDA+
Sbjct: 1939 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1998
Query: 1853 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1902
A A + L+E +A + + + E AL+ ++ E+L++ AE
Sbjct: 1999 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2058
Query: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1959
R L + +++ + + S S ER + L + TL + V+ +E+L
Sbjct: 2059 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2117
Query: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2014
+ E + + ++ L ++ + ++ A RQ + A E+ ++ E
Sbjct: 2118 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2174
Query: 2015 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2068
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q E
Sbjct: 2175 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2234
Query: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2127
E + Q QE + + L+ L + +++A V +
Sbjct: 2235 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2288
Query: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
++ +++E+ + K+ A Q + A K K +E ++ Q + +
Sbjct: 2289 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2348
Query: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2241
+ +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2349 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2407
Query: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2294
E T + + L S++ M ++S E+ L+L+DK NT+ + Q
Sbjct: 2408 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2462
Query: 2295 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK
Sbjct: 2463 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2519
Query: 2354 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+ ELL++ + + ++ +L D++Q ++ + FQ T+EA
Sbjct: 2520 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2578
Query: 2398 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2579 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2638
Query: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2491
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2639 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2698
Query: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2699 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2754
Query: 2552 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ +
Sbjct: 2755 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2814
Query: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
+ A +L +LE + S+ +TA KT+ G + L
Sbjct: 2815 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2857
Score = 619 bits (1597), Expect = e-176
Identities = 304/503 (60%), Positives = 400/503 (79%), Gaps = 6/503 (1%)
Query: 13 EDVSNGS-SGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQ 71
+D S S S SP+PGDTLPWNL K +RS+R G GSVLDPAERAV+RIADERD+VQ
Sbjct: 11 DDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQG----GSVLDPAERAVLRIADERDKVQ 66
Query: 72 KKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQ 131
KKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRFH+LQNVQ
Sbjct: 67 KKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQ 126
Query: 132 IALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKL 191
IALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SEDM+AKE+L
Sbjct: 127 IALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERL 186
Query: 192 LLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFS 251
LLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL NL+ AF
Sbjct: 187 LLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFY 246
Query: 252 VAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEY 311
VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN+++++W EY
Sbjct: 247 VAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEY 305
Query: 312 RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQ 371
+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K++ K +Y+
Sbjct: 306 QNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYK 365
Query: 372 SLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME 431
LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I ++Q +
Sbjct: 366 LLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRD 425
Query: 432 AGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRH 491
+ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ L DG++
Sbjct: 426 SVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKY 485
Query: 492 PQGEQMYRRVYRLHERLVAIRTE 514
Q +Q+ +RV +L + ++A+R E
Sbjct: 486 YQADQLVQRVAKLRDEIMALRNE 508
Score = 111 bits (277), Expect = 2e-23
Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)
Query: 986 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1045
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 2665 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2724
Query: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1105
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 2725 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2774
Query: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1157
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 2775 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2834
Query: 1158 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 2835 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2878
Query: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 2879 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2936
Query: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1307
+ + ++L +E+++H VE A ++ K
Sbjct: 2937 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2996
Query: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1366
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 2997 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3056
Query: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 3057 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3115
Query: 1426 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 3116 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3174
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1526
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 3175 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3233
Query: 1527 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1560
+ + +ESQ E E ++ K E E + KQ+
Sbjct: 3234 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3293
Query: 1561 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1593
+ Q LE + L + +RA Q+Q A
Sbjct: 3294 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3353
Query: 1594 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650
L Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 3354 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3412
Query: 1651 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1698
+ + L RW+ N+A Q E VAQQ ++L EK+ E
Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472
Query: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3529
Query: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 3530 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3586
Query: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1869
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 3587 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3641
Query: 1870 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1923
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 3642 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3701
Query: 1924 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1971
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 3702 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3760
Query: 1972 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2024
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 3761 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3820
Query: 2025 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 3821 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3876
Query: 2079 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2133
+A + Q + +EL L + QS++ QL E E R+ EE + R
Sbjct: 3877 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3936
Query: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2189
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 3937 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3996
Query: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2246
D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E
Sbjct: 3997 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055
Query: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
+ ++++ + VQ KL + EN ++ +++ + E AEK +
Sbjct: 4056 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4109
Query: 2306 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2359
+ + +R L + + +Q+ A + ++E++ +QE + +EL+
Sbjct: 4110 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4169
Query: 2360 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
+ K + ++ L + + + + + ++A Q Q + A + + +
Sbjct: 4170 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4229
Query: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
+++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L
Sbjct: 4230 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4277
Query: 2476 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2523
+ + E E +K +Q E KL+ EE +Q +L AL Q ++L
Sbjct: 4278 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4336
Query: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2579
+ + LL ++ + + +E E+AK L+ + Q +E + L+ S
Sbjct: 4337 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4392
Query: 2580 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2635
EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R
Sbjct: 4393 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4452
Query: 2636 LA 2637
LA
Sbjct: 4453 LA 4454
Score = 94.0 bits (232), Expect = 3e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1030
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3247
Query: 1031 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 3248 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3298
Query: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 3299 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3357
Query: 1143 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 3358 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3410
Query: 1203 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 3411 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3470
Query: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 3471 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3529
Query: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1379
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 3530 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3588
Query: 1380 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1423
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 3589 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3648
Query: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1477
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 3649 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3708
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 3709 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3763
Query: 1538 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1586
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 3764 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3823
Query: 1587 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1622
+ V+ + +E E QS + +E+ QLER+
Sbjct: 3824 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3883
Query: 1623 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1664
L E ++QL E E QQQ E + RE E + +++
Sbjct: 3884 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3943
Query: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 3944 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4003
Query: 1724 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1777
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 4004 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4063
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1832
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 4064 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4113
Query: 1833 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 4114 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4164
Query: 1889 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 4165 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4212
Query: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 4213 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4268
Query: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 4269 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4326
Query: 2068 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
A + L +QK E EL + + VL + EA +A
Sbjct: 4327 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4385
Query: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 4386 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4432
Query: 2179 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 4433 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4490
Query: 2233 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 4491 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4546
Query: 2289 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2337
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 4547 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4606
Query: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4665
Query: 2398 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 4666 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4717
Query: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2512
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 4718 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4759
Query: 2513 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 4760 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4819
Query: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2613
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 4820 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4879
Query: 2614 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2650
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 4880 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4926
Score = 85.1 bits (209), Expect = 1e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 1153 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1207
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 3697 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3741
Query: 1208 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 3742 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3801
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 3802 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3858
Query: 1325 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1370
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 3859 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3918
Query: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 3919 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3978
Query: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1482
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 3979 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4037
Query: 1483 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1535
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 4038 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093
Query: 1536 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1585
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4152
Query: 1586 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
++ + + E E + + S E + + SL + EEA +
Sbjct: 4153 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4211
Query: 1641 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1693
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 4212 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4271
Query: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 4272 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4323
Query: 1754 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1807
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 4324 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4383
Query: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 4384 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4433
Query: 1868 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1916
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 4434 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4493
Query: 1917 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1967
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 4494 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4551
Query: 1968 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 4552 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4604
Query: 2024 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2068
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 4605 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4664
Query: 2069 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 4665 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4722
Query: 2122 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 4723 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781
Query: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 4782 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4836
Query: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2284
++Q L + L + Q EE L+ EAE ++
Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896
Query: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2336
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 4897 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4956
Query: 2337 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2391
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 4957 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5016
Query: 2392 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2444
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 5017 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5076
Query: 2445 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 5077 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5130
Query: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 5131 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5167
Score = 78.6 bits (192), Expect = 1e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 539 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 591
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 3325 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3384
Query: 592 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 3385 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3443
Query: 648 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 701
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 3444 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3503
Query: 702 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 740
+ G L + +R + Q+ L W +LQ C
Sbjct: 3504 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3561
Query: 741 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 789
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 3562 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3620
Query: 790 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 837
L Q DE +++L K + +AK + +QL R H H
Sbjct: 3621 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3680
Query: 838 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 891
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 3681 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3739
Query: 892 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 946
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 3740 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3799
Query: 947 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 990
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 3800 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3859
Query: 991 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1039
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 3860 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3919
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 3920 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3977
Query: 1100 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 3978 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4027
Query: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1213
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4080
Query: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 4081 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4139
Query: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 4140 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4188
Query: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 4189 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4240
Query: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 4241 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4297
Query: 1453 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1503
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 4298 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4357
Query: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1562
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 4358 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4414
Query: 1563 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 4415 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4468
Query: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1660
++ E A + +EE + Q+ + AR E E +L
Sbjct: 4469 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4528
Query: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 4529 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4588
Query: 1721 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 4589 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4648
Query: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 4649 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4703
Query: 1837 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1890
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 4704 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4763
Query: 1891 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 4764 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4823
Query: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 4824 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4869
Query: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 4870 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4928
Query: 2070 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 4929 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4984
Query: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2177
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 4985 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5043
Query: 2178 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 5044 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5095
Query: 2237 QRLKAEATEAARQRSQVEEELFSVR 2261
Q++ A E R+ + + L +R
Sbjct: 5096 QQVWLLALERRRKLNDALDRLEELR 5120
Score = 69.3 bits (168), Expect = 8e-11
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1096
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 4247 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4299
Query: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1152
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 4300 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356
Query: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4407
Query: 1213 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1271
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 4408 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4465
Query: 1272 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1312
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 4466 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4525
Query: 1313 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1372
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 4526 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4579
Query: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 4580 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628
Query: 1433 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1488
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4688
Query: 1489 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1544
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4748
Query: 1545 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 4749 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4804
Query: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 4805 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4847
Query: 1663 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 4848 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4906
Query: 1719 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 4907 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4966
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1830
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 4967 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5026
Query: 1831 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1880
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 5027 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5086
Query: 1881 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1919
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 5087 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5146
Query: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1978
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 5147 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5205
Query: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
N + + ++E RQ+A + +R + E+
Sbjct: 5206 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5242
Score = 40.0 bits (92), Expect = 0.053
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 1067 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1125
Query: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
+ E +F + Q KLK +E L+++ + EE
Sbjct: 1126 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1165
Query: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 1166 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1224
Query: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 1225 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1283
Query: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 1284 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1343
Query: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 1344 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1394
Query: 2548 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 1395 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1440
Query: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 1441 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1500
Query: 2665 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2694
++ + +++ ++ LQ + A+
Sbjct: 1501 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1530
Score = 35.0 bits (79), Expect = 1.7
Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)
Query: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 450
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 4622 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4674
Query: 451 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 510
E+ D DK + + + Q +H + R L E+
Sbjct: 4675 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4720
Query: 511 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 562
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 4721 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4778
Query: 563 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 622
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 4779 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4833
Query: 623 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 668
+ +Q +L L+ SK A LR E HS V A L WL E E+ +
Sbjct: 4834 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4889
Query: 669 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 715
F D + + + M++LE K ++ + GD +L HP
Sbjct: 4890 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4938
Score = 35.0 bits (79), Expect = 1.7
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 4484 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 5422 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5472
Score = 32.7 bits (73), Expect = 8.5
Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)
Query: 532 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 584
+V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL
Sbjct: 4630 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4689
Query: 585 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 639
H+ +S+ + + L T A D L L ++ + S R
Sbjct: 4690 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4749
Query: 640 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 691
LE F T L WL E E++ D N+ +++ A +E
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4806
Query: 692 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 751
L + ++ L+ + L+ V+ L T+W + L + L+
Sbjct: 4807 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4866
Query: 752 FQFFSDVREA 761
+ F V A
Sbjct: 4867 AEEFHSVVHA 4876
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 861 bits (2224), Expect = 0.0
Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
Query: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
Query: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
Query: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1483
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
Query: 1484 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Query: 1534 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1591
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
Query: 1592 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1647
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
Query: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1697
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
Query: 1698 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1752
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
Query: 1753 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
Query: 1807 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1852
S S++ +++ A R+L R R+L + + L + EDA+
Sbjct: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
Query: 1853 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1902
A A + L+E +A + + + E AL+ ++ E+L++ AE
Sbjct: 2010 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2069
Query: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1959
R L + +++ + + S S ER + L + TL + V+ +E+L
Sbjct: 2070 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2128
Query: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2014
+ E + + ++ L ++ + ++ A RQ + A E+ ++ E
Sbjct: 2129 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2185
Query: 2015 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2068
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q E
Sbjct: 2186 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2245
Query: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2127
E + Q QE + + L+ L + +++A V +
Sbjct: 2246 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2299
Query: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
++ +++E+ + K+ A Q + A K K +E ++ Q + +
Sbjct: 2300 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2359
Query: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2241
+ +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2360 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2418
Query: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2294
E T + + L S++ M ++S E+ L+L+DK NT+ + Q
Sbjct: 2419 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2473
Query: 2295 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK
Sbjct: 2474 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2530
Query: 2354 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+ ELL++ + + ++ +L D++Q ++ + FQ T+EA
Sbjct: 2531 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2589
Query: 2398 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2590 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2649
Query: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2491
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2650 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2709
Query: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2710 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2765
Query: 2552 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ +
Sbjct: 2766 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2825
Query: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
+ A +L +LE + S+ +TA KT+ G + L
Sbjct: 2826 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
Score = 619 bits (1597), Expect = e-176
Identities = 304/503 (60%), Positives = 400/503 (79%), Gaps = 6/503 (1%)
Query: 13 EDVSNGS-SGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQ 71
+D S S S SP+PGDTLPWNL K +RS+R G GSVLDPAERAV+RIADERD+VQ
Sbjct: 22 DDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQG----GSVLDPAERAVLRIADERDKVQ 77
Query: 72 KKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQ 131
KKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRFH+LQNVQ
Sbjct: 78 KKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQ 137
Query: 132 IALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKL 191
IALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SEDM+AKE+L
Sbjct: 138 IALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERL 197
Query: 192 LLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFS 251
LLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL NL+ AF
Sbjct: 198 LLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFY 257
Query: 252 VAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEY 311
VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN+++++W EY
Sbjct: 258 VAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEY 316
Query: 312 RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQ 371
+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K++ K +Y+
Sbjct: 317 QNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYK 376
Query: 372 SLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME 431
LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I ++Q +
Sbjct: 377 LLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRD 436
Query: 432 AGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRH 491
+ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ L DG++
Sbjct: 437 SVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKY 496
Query: 492 PQGEQMYRRVYRLHERLVAIRTE 514
Q +Q+ +RV +L + ++A+R E
Sbjct: 497 YQADQLVQRVAKLRDEIMALRNE 519
Score = 111 bits (277), Expect = 2e-23
Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)
Query: 986 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1045
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
Query: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1105
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Query: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1157
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
Query: 1158 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
Query: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2947
Query: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1307
+ + ++L +E+++H VE A ++ K
Sbjct: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
Query: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1366
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
Query: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3126
Query: 1426 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1526
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
Query: 1527 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1560
+ + +ESQ E E ++ K E E + KQ+
Sbjct: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
Query: 1561 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1593
+ Q LE + L + +RA Q+Q A
Sbjct: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Query: 1594 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650
L Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Query: 1651 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1698
+ + L RW+ N+A Q E VAQQ ++L EK+ E
Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
Query: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
Query: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3597
Query: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1869
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
Query: 1870 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1923
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
Query: 1924 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1971
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Query: 1972 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2024
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
Query: 2025 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3887
Query: 2079 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2133
+A + Q + +EL L + QS++ QL E E R+ EE + R
Sbjct: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
Query: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2189
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 4007
Query: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2246
D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E
Sbjct: 4008 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
Query: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
+ ++++ + VQ KL + EN ++ +++ + E AEK +
Sbjct: 4067 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4120
Query: 2306 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2359
+ + +R L + + +Q+ A + ++E++ +QE + +EL+
Sbjct: 4121 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4180
Query: 2360 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
+ K + ++ L + + + + + ++A Q Q + A + + +
Sbjct: 4181 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4240
Query: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
+++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L
Sbjct: 4241 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4288
Query: 2476 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2523
+ + E E +K +Q E KL+ EE +Q +L AL Q ++L
Sbjct: 4289 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4347
Query: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2579
+ + LL ++ + + +E E+AK L+ + Q +E + L+ S
Sbjct: 4348 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4403
Query: 2580 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2635
EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R
Sbjct: 4404 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4463
Query: 2636 LA 2637
LA
Sbjct: 4464 LA 4465
Score = 94.0 bits (232), Expect = 3e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1030
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
Query: 1031 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
Query: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
Query: 1143 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
Query: 1203 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
Query: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
Query: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1379
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
Query: 1380 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1423
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
Query: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1477
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
Query: 1538 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1586
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
Query: 1587 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1622
+ V+ + +E E QS + +E+ QLER+
Sbjct: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
Query: 1623 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1664
L E ++QL E E QQQ E + RE E + +++
Sbjct: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
Query: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
Query: 1724 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1777
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1832
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
Query: 1833 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
Query: 1889 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
Query: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Query: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
Query: 2068 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
A + L +QK E EL + + VL + EA +A
Sbjct: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
Query: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
Query: 2179 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
Query: 2233 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
Query: 2289 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2337
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Query: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
Query: 2398 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
Query: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2512
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
Query: 2513 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Query: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2613
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
Query: 2614 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2650
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
Score = 85.1 bits (209), Expect = 1e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 1153 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1207
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
Query: 1208 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
Query: 1325 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1370
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
Query: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
Query: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1482
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
Query: 1483 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1535
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
Query: 1536 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1585
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
Query: 1586 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
++ + + E E + + S E + + SL + EEA +
Sbjct: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
Query: 1641 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1693
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
Query: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
Query: 1754 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1807
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Query: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
Query: 1868 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1916
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
Query: 1917 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1967
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
Query: 1968 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
Query: 2024 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2068
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
Query: 2069 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
Query: 2122 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
Query: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
Query: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2284
++Q L + L + Q EE L+ EAE ++
Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
Query: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2336
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
Query: 2337 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2391
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
Query: 2392 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2444
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Query: 2445 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
Query: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
Score = 78.6 bits (192), Expect = 1e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 539 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 591
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
Query: 592 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
Query: 648 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 701
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
Query: 702 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 740
+ G L + +R + Q+ L W +LQ C
Sbjct: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
Query: 741 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 789
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
Query: 790 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 837
L Q DE +++L K + +AK + +QL R H H
Sbjct: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
Query: 838 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 891
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
Query: 892 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 946
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
Query: 947 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 990
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
Query: 991 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1039
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
Query: 1100 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
Query: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1213
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
Query: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
Query: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Query: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
Query: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
Query: 1453 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1503
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
Query: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1562
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
Query: 1563 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
Query: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1660
++ E A + +EE + Q+ + AR E E +L
Sbjct: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
Query: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
Query: 1721 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
Query: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
Query: 1837 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1890
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
Query: 1891 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
Query: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
Query: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
Query: 2070 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
Query: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2177
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
Query: 2178 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
Query: 2237 QRLKAEATEAARQRSQVEEELFSVR 2261
Q++ A E R+ + + L +R
Sbjct: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Score = 69.3 bits (168), Expect = 8e-11
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1096
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
Query: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1152
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
Query: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
Query: 1213 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1271
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
Query: 1272 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1312
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
Query: 1313 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1372
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
Query: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
Query: 1433 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1488
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
Query: 1489 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1544
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
Query: 1545 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
Query: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
Query: 1663 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
Query: 1719 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1830
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Query: 1831 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1880
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
Query: 1881 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1919
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
Query: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1978
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
Query: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
N + + ++E RQ+A + +R + E+
Sbjct: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
Score = 40.0 bits (92), Expect = 0.053
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
Query: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
+ E +F + Q KLK +E L+++ + EE
Sbjct: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
Query: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
Query: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
Query: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
Query: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
Query: 2548 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
Query: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Query: 2665 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2694
++ + +++ ++ LQ + A+
Sbjct: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
Score = 35.0 bits (79), Expect = 1.7
Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)
Query: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 450
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
Query: 451 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 510
E+ D DK + + + Q +H + R L E+
Sbjct: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
Query: 511 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 562
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
Query: 563 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 622
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Query: 623 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 668
+ +Q +L L+ SK A LR E HS V A L WL E E+ +
Sbjct: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4900
Query: 669 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 715
F D + + + M++LE K ++ + GD +L HP
Sbjct: 4901 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
Score = 35.0 bits (79), Expect = 1.7
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 4484 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
Score = 32.7 bits (73), Expect = 8.5
Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)
Query: 532 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 584
+V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL
Sbjct: 4641 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4700
Query: 585 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 639
H+ +S+ + + L T A D L L ++ + S R
Sbjct: 4701 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4760
Query: 640 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 691
LE F T L WL E E++ D N+ +++ A +E
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4817
Query: 692 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 751
L + ++ L+ + L+ V+ L T+W + L + L+
Sbjct: 4818 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877
Query: 752 FQFFSDVREA 761
+ F V A
Sbjct: 4878 AEEFHSVVHA 4887
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 861 bits (2224), Expect = 0.0
Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 779 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 838
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 839 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 899 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 958
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 959 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 1018
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 1019 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 1078
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 1079 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1138
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 1139 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1198
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 1199 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1258
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 1259 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1318
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1319 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1378
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1379 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1438
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1439 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1498
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1499 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1558
Query: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1559 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1618
Query: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1619 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1671
Query: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1483
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1672 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1730
Query: 1484 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1731 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1788
Query: 1534 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1591
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1789 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1848
Query: 1592 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1647
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1849 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1908
Query: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1697
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1909 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1967
Query: 1698 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1752
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1968 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 2027
Query: 1753 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 2028 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 2087
Query: 1807 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1852
S S++ +++ A R+L R R+L + + L + EDA+
Sbjct: 2088 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2147
Query: 1853 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1902
A A + L+E +A + + + E AL+ ++ E+L++ AE
Sbjct: 2148 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2207
Query: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1959
R L + +++ + + S S ER + L + TL + V+ +E+L
Sbjct: 2208 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2266
Query: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2014
+ E + + ++ L ++ + ++ A RQ + A E+ ++ E
Sbjct: 2267 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2323
Query: 2015 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2068
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q E
Sbjct: 2324 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2383
Query: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2127
E + Q QE + + L+ L + +++A V +
Sbjct: 2384 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2437
Query: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
++ +++E+ + K+ A Q + A K K +E ++ Q + +
Sbjct: 2438 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2497
Query: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2241
+ +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2498 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2556
Query: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2294
E T + + L S++ M ++S E+ L+L+DK NT+ + Q
Sbjct: 2557 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2611
Query: 2295 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK
Sbjct: 2612 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2668
Query: 2354 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+ ELL++ + + ++ +L D++Q ++ + FQ T+EA
Sbjct: 2669 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2727
Query: 2398 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2728 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2787
Query: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2491
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2788 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2847
Query: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2848 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2903
Query: 2552 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ +
Sbjct: 2904 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2963
Query: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
+ A +L +LE + S+ +TA KT+ G + L
Sbjct: 2964 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 3006
Score = 619 bits (1597), Expect = e-176
Identities = 304/503 (60%), Positives = 400/503 (79%), Gaps = 6/503 (1%)
Query: 13 EDVSNGS-SGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQ 71
+D S S S SP+PGDTLPWNL K +RS+R G GSVLDPAERAV+RIADERD+VQ
Sbjct: 160 DDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQG----GSVLDPAERAVLRIADERDKVQ 215
Query: 72 KKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQ 131
KKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRFH+LQNVQ
Sbjct: 216 KKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQ 275
Query: 132 IALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKL 191
IALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SEDM+AKE+L
Sbjct: 276 IALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERL 335
Query: 192 LLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFS 251
LLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL NL+ AF
Sbjct: 336 LLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFY 395
Query: 252 VAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEY 311
VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN+++++W EY
Sbjct: 396 VAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEY 454
Query: 312 RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQ 371
+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K++ K +Y+
Sbjct: 455 QNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYK 514
Query: 372 SLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME 431
LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I ++Q +
Sbjct: 515 LLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRD 574
Query: 432 AGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRH 491
+ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ L DG++
Sbjct: 575 SVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKY 634
Query: 492 PQGEQMYRRVYRLHERLVAIRTE 514
Q +Q+ +RV +L + ++A+R E
Sbjct: 635 YQADQLVQRVAKLRDEIMALRNE 657
Score = 111 bits (277), Expect = 2e-23
Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)
Query: 986 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1045
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 2814 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2873
Query: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1105
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 2874 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2923
Query: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1157
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 2924 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2983
Query: 1158 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 2984 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 3027
Query: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 3028 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 3085
Query: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1307
+ + ++L +E+++H VE A ++ K
Sbjct: 3086 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3145
Query: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1366
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 3146 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3205
Query: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 3206 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3264
Query: 1426 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 3265 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3323
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1526
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 3324 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3382
Query: 1527 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1560
+ + +ESQ E E ++ K E E + KQ+
Sbjct: 3383 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3442
Query: 1561 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1593
+ Q LE + L + +RA Q+Q A
Sbjct: 3443 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3502
Query: 1594 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650
L Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 3503 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3561
Query: 1651 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1698
+ + L RW+ N+A Q E VAQQ ++L EK+ E
Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621
Query: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3678
Query: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 3679 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3735
Query: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1869
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 3736 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3790
Query: 1870 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1923
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 3791 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3850
Query: 1924 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1971
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 3851 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3909
Query: 1972 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2024
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 3910 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3969
Query: 2025 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 3970 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 4025
Query: 2079 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2133
+A + Q + +EL L + QS++ QL E E R+ EE + R
Sbjct: 4026 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 4085
Query: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2189
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 4086 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 4145
Query: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2246
D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E
Sbjct: 4146 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204
Query: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
+ ++++ + VQ KL + EN ++ +++ + E AEK +
Sbjct: 4205 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4258
Query: 2306 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2359
+ + +R L + + +Q+ A + ++E++ +QE + +EL+
Sbjct: 4259 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4318
Query: 2360 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
+ K + ++ L + + + + + ++A Q Q + A + + +
Sbjct: 4319 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4378
Query: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
+++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L
Sbjct: 4379 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4426
Query: 2476 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2523
+ + E E +K +Q E KL+ EE +Q +L AL Q ++L
Sbjct: 4427 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4485
Query: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2579
+ + LL ++ + + +E E+AK L+ + Q +E + L+ S
Sbjct: 4486 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4541
Query: 2580 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2635
EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R
Sbjct: 4542 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4601
Query: 2636 LA 2637
LA
Sbjct: 4602 LA 4603
Score = 94.0 bits (232), Expect = 3e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1030
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3396
Query: 1031 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 3397 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3447
Query: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 3448 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3506
Query: 1143 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 3507 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559
Query: 1203 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 3560 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3619
Query: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 3620 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3678
Query: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1379
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 3679 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3737
Query: 1380 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1423
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 3738 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3797
Query: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1477
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 3798 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3857
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 3858 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3912
Query: 1538 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1586
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 3913 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3972
Query: 1587 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1622
+ V+ + +E E QS + +E+ QLER+
Sbjct: 3973 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 4032
Query: 1623 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1664
L E ++QL E E QQQ E + RE E + +++
Sbjct: 4033 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 4092
Query: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 4093 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4152
Query: 1724 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1777
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 4153 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4212
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1832
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 4213 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4262
Query: 1833 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 4263 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4313
Query: 1889 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 4314 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4361
Query: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 4362 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4417
Query: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 4418 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4475
Query: 2068 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
A + L +QK E EL + + VL + EA +A
Sbjct: 4476 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4534
Query: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 4535 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4581
Query: 2179 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 4582 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4639
Query: 2233 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 4640 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4695
Query: 2289 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2337
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 4696 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4755
Query: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4814
Query: 2398 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 4815 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4866
Query: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2512
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 4867 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4908
Query: 2513 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 4909 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4968
Query: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2613
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 4969 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 5028
Query: 2614 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2650
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 5029 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 5075
Score = 85.1 bits (209), Expect = 1e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 1153 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1207
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 3846 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3890
Query: 1208 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 3891 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3950
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 3951 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 4007
Query: 1325 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1370
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 4008 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 4067
Query: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 4068 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 4127
Query: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1482
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 4128 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4186
Query: 1483 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1535
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 4187 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242
Query: 1536 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1585
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4301
Query: 1586 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
++ + + E E + + S E + + SL + EEA +
Sbjct: 4302 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4360
Query: 1641 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1693
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 4361 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4420
Query: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 4421 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4472
Query: 1754 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1807
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 4473 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4532
Query: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 4533 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4582
Query: 1868 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1916
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 4583 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4642
Query: 1917 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1967
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 4643 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4700
Query: 1968 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 4701 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4753
Query: 2024 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2068
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 4754 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4813
Query: 2069 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 4814 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4871
Query: 2122 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 4872 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930
Query: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 4931 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4985
Query: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2284
++Q L + L + Q EE L+ EAE ++
Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045
Query: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2336
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 5046 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 5105
Query: 2337 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2391
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 5106 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5165
Query: 2392 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2444
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 5166 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5225
Query: 2445 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 5226 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5279
Query: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 5280 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5316
Score = 78.6 bits (192), Expect = 1e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 539 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 591
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 3474 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3533
Query: 592 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 3534 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3592
Query: 648 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 701
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 3593 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3652
Query: 702 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 740
+ G L + +R + Q+ L W +LQ C
Sbjct: 3653 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3710
Query: 741 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 789
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 3711 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3769
Query: 790 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 837
L Q DE +++L K + +AK + +QL R H H
Sbjct: 3770 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3829
Query: 838 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 891
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 3830 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3888
Query: 892 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 946
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 3889 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3948
Query: 947 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 990
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 3949 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 4008
Query: 991 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1039
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 4009 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 4068
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 4069 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 4126
Query: 1100 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 4127 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4176
Query: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1213
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4229
Query: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 4230 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4288
Query: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 4289 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4337
Query: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 4338 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4389
Query: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 4390 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4446
Query: 1453 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1503
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 4447 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4506
Query: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1562
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 4507 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4563
Query: 1563 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 4564 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4617
Query: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1660
++ E A + +EE + Q+ + AR E E +L
Sbjct: 4618 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4677
Query: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 4678 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4737
Query: 1721 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 4738 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4797
Query: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 4798 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4852
Query: 1837 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1890
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 4853 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4912
Query: 1891 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 4913 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4972
Query: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 4973 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 5018
Query: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 5019 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 5077
Query: 2070 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 5078 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 5133
Query: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2177
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 5134 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5192
Query: 2178 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 5193 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5244
Query: 2237 QRLKAEATEAARQRSQVEEELFSVR 2261
Q++ A E R+ + + L +R
Sbjct: 5245 QQVWLLALERRRKLNDALDRLEELR 5269
Score = 69.3 bits (168), Expect = 8e-11
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1096
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 4396 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4448
Query: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1152
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 4449 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505
Query: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4556
Query: 1213 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1271
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 4557 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4614
Query: 1272 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1312
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 4615 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4674
Query: 1313 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1372
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 4675 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4728
Query: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 4729 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777
Query: 1433 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1488
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4837
Query: 1489 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1544
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4897
Query: 1545 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 4898 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4953
Query: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 4954 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4996
Query: 1663 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 4997 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 5055
Query: 1719 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 5056 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 5115
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1830
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 5116 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5175
Query: 1831 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1880
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 5176 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5235
Query: 1881 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1919
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 5236 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5295
Query: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1978
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 5296 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5354
Query: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
N + + ++E RQ+A + +R + E+
Sbjct: 5355 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5391
Score = 40.0 bits (92), Expect = 0.053
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 1216 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1274
Query: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
+ E +F + Q KLK +E L+++ + EE
Sbjct: 1275 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1314
Query: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 1315 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1373
Query: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 1374 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1432
Query: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 1433 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1492
Query: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 1493 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1543
Query: 2548 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 1544 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1589
Query: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 1590 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1649
Query: 2665 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2694
++ + +++ ++ LQ + A+
Sbjct: 1650 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1679
Score = 35.0 bits (79), Expect = 1.7
Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)
Query: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 450
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 4771 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4823
Query: 451 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 510
E+ D DK + + + Q +H + R L E+
Sbjct: 4824 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4869
Query: 511 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 562
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 4870 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4927
Query: 563 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 622
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 4928 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4982
Query: 623 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 668
+ +Q +L L+ SK A LR E HS V A L WL E E+ +
Sbjct: 4983 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 5038
Query: 669 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 715
F D + + + M++LE K ++ + GD +L HP
Sbjct: 5039 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 5087
Score = 35.0 bits (79), Expect = 1.7
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 4484 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 5571 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5621
Score = 32.7 bits (73), Expect = 8.5
Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)
Query: 532 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 584
+V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL
Sbjct: 4779 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4838
Query: 585 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 639
H+ +S+ + + L T A D L L ++ + S R
Sbjct: 4839 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4898
Query: 640 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 691
LE F T L WL E E++ D N+ +++ A +E
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4955
Query: 692 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 751
L + ++ L+ + L+ V+ L T+W + L + L+
Sbjct: 4956 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 5015
Query: 752 FQFFSDVREA 761
+ F V A
Sbjct: 5016 AEEFHSVVHA 5025
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 861 bits (2224), Expect = 0.0
Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 601 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 661 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 721 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 781 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 841 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 901 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 961 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
Query: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
Query: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
Query: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1483
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
Query: 1484 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
Query: 1534 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1591
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
Query: 1592 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1647
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
Query: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1697
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
Query: 1698 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1752
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
Query: 1753 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
Query: 1807 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1852
S S++ +++ A R+L R R+L + + L + EDA+
Sbjct: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
Query: 1853 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1902
A A + L+E +A + + + E AL+ ++ E+L++ AE
Sbjct: 1970 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2029
Query: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1959
R L + +++ + + S S ER + L + TL + V+ +E+L
Sbjct: 2030 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2088
Query: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2014
+ E + + ++ L ++ + ++ A RQ + A E+ ++ E
Sbjct: 2089 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2145
Query: 2015 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2068
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q E
Sbjct: 2146 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2205
Query: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2127
E + Q QE + + L+ L + +++A V +
Sbjct: 2206 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2259
Query: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
++ +++E+ + K+ A Q + A K K +E ++ Q + +
Sbjct: 2260 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2319
Query: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2241
+ +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2320 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2378
Query: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2294
E T + + L S++ M ++S E+ L+L+DK NT+ + Q
Sbjct: 2379 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2433
Query: 2295 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK
Sbjct: 2434 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2490
Query: 2354 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+ ELL++ + + ++ +L D++Q ++ + FQ T+EA
Sbjct: 2491 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2549
Query: 2398 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2550 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2609
Query: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2491
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2610 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2669
Query: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2670 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2725
Query: 2552 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ +
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2785
Query: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
+ A +L +LE + S+ +TA KT+ G + L
Sbjct: 2786 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
Score = 565 bits (1457), Expect = e-160
Identities = 273/462 (59%), Positives = 365/462 (79%), Gaps = 1/462 (0%)
Query: 53 LDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSG 112
L E + R DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSG
Sbjct: 19 LQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 78
Query: 113 DSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 172
D+LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQ
Sbjct: 79 DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 138
Query: 173 ISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232
ISDI V+G+SEDM+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LI
Sbjct: 139 ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 198
Query: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
DMN V Q+NL NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+V
Sbjct: 199 DMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKV 257
Query: 293 PDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 352
P+ +G+ AN+++++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FK
Sbjct: 258 PEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFK 317
Query: 353 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR 412
E E+P KE +K++ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR
Sbjct: 318 ETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALR 377
Query: 413 SEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKA 472
E ERLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + +
Sbjct: 378 PEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILEC 437
Query: 473 DSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 514
++++R DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 438 ENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
Score = 111 bits (277), Expect = 2e-23
Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)
Query: 986 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1045
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
Query: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1105
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
Query: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1157
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
Query: 1158 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
Query: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2907
Query: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1307
+ + ++L +E+++H VE A ++ K
Sbjct: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
Query: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1366
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
Query: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3086
Query: 1426 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1526
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
Query: 1527 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1560
+ + +ESQ E E ++ K E E + KQ+
Sbjct: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
Query: 1561 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1593
+ Q LE + L + +RA Q+Q A
Sbjct: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
Query: 1594 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650
L Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
Query: 1651 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1698
+ + L RW+ N+A Q E VAQQ ++L EK+ E
Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
Query: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
Query: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3557
Query: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1869
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
Query: 1870 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1923
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
Query: 1924 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1971
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
Query: 1972 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2024
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
Query: 2025 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3847
Query: 2079 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2133
+A + Q + +EL L + QS++ QL E E R+ EE + R
Sbjct: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
Query: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2189
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3967
Query: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2246
D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E
Sbjct: 3968 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026
Query: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
+ ++++ + VQ KL + EN ++ +++ + E AEK +
Sbjct: 4027 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4080
Query: 2306 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2359
+ + +R L + + +Q+ A + ++E++ +QE + +EL+
Sbjct: 4081 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4140
Query: 2360 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
+ K + ++ L + + + + + ++A Q Q + A + + +
Sbjct: 4141 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4200
Query: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
+++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L
Sbjct: 4201 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4248
Query: 2476 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2523
+ + E E +K +Q E KL+ EE +Q +L AL Q ++L
Sbjct: 4249 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4307
Query: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2579
+ + LL ++ + + +E E+AK L+ + Q +E + L+ S
Sbjct: 4308 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4363
Query: 2580 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2635
EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R
Sbjct: 4364 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4423
Query: 2636 LA 2637
LA
Sbjct: 4424 LA 4425
Score = 94.0 bits (232), Expect = 3e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1030
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
Query: 1031 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
Query: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
Query: 1143 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
Query: 1203 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
Query: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
Query: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1379
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
Query: 1380 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1423
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
Query: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1477
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
Query: 1538 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1586
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
Query: 1587 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1622
+ V+ + +E E QS + +E+ QLER+
Sbjct: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
Query: 1623 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1664
L E ++QL E E QQQ E + RE E + +++
Sbjct: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
Query: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
Query: 1724 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1777
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1832
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
Query: 1833 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
Query: 1889 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
Query: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
Query: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
Query: 2068 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
A + L +QK E EL + + VL + EA +A
Sbjct: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
Query: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
Query: 2179 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
Query: 2233 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
Query: 2289 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2337
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
Query: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
Query: 2398 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
Query: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2512
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
Query: 2513 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
Query: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2613
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
Query: 2614 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2650
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
Score = 85.1 bits (209), Expect = 1e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 1153 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1207
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
Query: 1208 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
Query: 1325 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1370
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
Query: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
Query: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1482
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
Query: 1483 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1535
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
Query: 1536 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1585
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
Query: 1586 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
++ + + E E + + S E + + SL + EEA +
Sbjct: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
Query: 1641 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1693
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
Query: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
Query: 1754 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1807
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
Query: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
Query: 1868 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1916
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
Query: 1917 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1967
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
Query: 1968 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
Query: 2024 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2068
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
Query: 2069 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
Query: 2122 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
Query: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
Query: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2284
++Q L + L + Q EE L+ EAE ++
Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
Query: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2336
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
Query: 2337 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2391
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
Query: 2392 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2444
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
Query: 2445 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
Query: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
Score = 78.6 bits (192), Expect = 1e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 539 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 591
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
Query: 592 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
Query: 648 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 701
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
Query: 702 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 740
+ G L + +R + Q+ L W +LQ C
Sbjct: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
Query: 741 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 789
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
Query: 790 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 837
L Q DE +++L K + +AK + +QL R H H
Sbjct: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
Query: 838 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 891
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
Query: 892 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 946
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
Query: 947 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 990
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
Query: 991 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1039
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
Query: 1100 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
Query: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1213
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
Query: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
Query: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
Query: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
Query: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
Query: 1453 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1503
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
Query: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1562
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
Query: 1563 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
Query: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1660
++ E A + +EE + Q+ + AR E E +L
Sbjct: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
Query: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
Query: 1721 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
Query: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
Query: 1837 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1890
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
Query: 1891 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
Query: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
Query: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
Query: 2070 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
Query: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2177
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
Query: 2178 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
Query: 2237 QRLKAEATEAARQRSQVEEELFSVR 2261
Q++ A E R+ + + L +R
Sbjct: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
Score = 69.3 bits (168), Expect = 8e-11
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1096
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
Query: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1152
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
Query: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
Query: 1213 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1271
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
Query: 1272 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1312
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
Query: 1313 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1372
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
Query: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
Query: 1433 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1488
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
Query: 1489 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1544
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
Query: 1545 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
Query: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
Query: 1663 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
Query: 1719 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1830
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
Query: 1831 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1880
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
Query: 1881 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1919
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
Query: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1978
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
Query: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
N + + ++E RQ+A + +R + E+
Sbjct: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
Score = 40.0 bits (92), Expect = 0.053
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
Query: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
+ E +F + Q KLK +E L+++ + EE
Sbjct: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
Query: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
Query: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
Query: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
Query: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
Query: 2548 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
Query: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
Query: 2665 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2694
++ + +++ ++ LQ + A+
Sbjct: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
Score = 35.0 bits (79), Expect = 1.7
Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)
Query: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 450
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
Query: 451 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 510
E+ D DK + + + Q +H + R L E+
Sbjct: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
Query: 511 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 562
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
Query: 563 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 622
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
Query: 623 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 668
+ +Q +L L+ SK A LR E HS V A L WL E E+ +
Sbjct: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4860
Query: 669 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 715
F D + + + M++LE K ++ + GD +L HP
Sbjct: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
Score = 35.0 bits (79), Expect = 1.7
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 4484 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
Score = 32.7 bits (73), Expect = 8.5
Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)
Query: 532 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 584
+V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL
Sbjct: 4601 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4660
Query: 585 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 639
H+ +S+ + + L T A D L L ++ + S R
Sbjct: 4661 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4720
Query: 640 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 691
LE F T L WL E E++ D N+ +++ A +E
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4777
Query: 692 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 751
L + ++ L+ + L+ V+ L T+W + L + L+
Sbjct: 4778 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837
Query: 752 FQFFSDVREA 761
+ F V A
Sbjct: 4838 AEEFHSVVHA 4847
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 861 bits (2224), Expect = 0.0
Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
Query: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
Query: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
Query: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1483
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1226
Query: 1484 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1227 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1284
Query: 1534 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1591
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1285 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1344
Query: 1592 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1647
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1345 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1404
Query: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1697
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1405 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1463
Query: 1698 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1752
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1464 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1523
Query: 1753 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1524 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1583
Query: 1807 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1852
S S++ +++ A R+L R R+L + + L + EDA+
Sbjct: 1584 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1643
Query: 1853 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1902
A A + L+E +A + + + E AL+ ++ E+L++ AE
Sbjct: 1644 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 1703
Query: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1959
R L + +++ + + S S ER + L + TL + V+ +E+L
Sbjct: 1704 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 1762
Query: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2014
+ E + + ++ L ++ + ++ A RQ + A E+ ++ E
Sbjct: 1763 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 1819
Query: 2015 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2068
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q E
Sbjct: 1820 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 1879
Query: 2069 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2127
E + Q QE + + L+ L + +++A V +
Sbjct: 1880 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 1933
Query: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
++ +++E+ + K+ A Q + A K K +E ++ Q + +
Sbjct: 1934 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 1993
Query: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2241
+ +E KK E+ + ++++ ++ L T K + + L
Sbjct: 1994 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2052
Query: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2294
E T + + L S++ M ++S E+ L+L+DK NT+ + Q
Sbjct: 2053 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2107
Query: 2295 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353
EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK
Sbjct: 2108 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2164
Query: 2354 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+ ELL++ + + ++ +L D++Q ++ + FQ T+EA
Sbjct: 2165 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2223
Query: 2398 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2439
+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2224 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2283
Query: 2440 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2491
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2284 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2343
Query: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2344 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2399
Query: 2552 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ +
Sbjct: 2400 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2459
Query: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
+ A +L +LE + S+ +TA KT+ G + L
Sbjct: 2460 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2502
Score = 111 bits (277), Expect = 2e-23
Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)
Query: 986 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1045
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 2310 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2369
Query: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1105
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 2370 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2419
Query: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1157
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 2420 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2479
Query: 1158 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 2480 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2523
Query: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 2524 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2581
Query: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1307
+ + ++L +E+++H VE A ++ K
Sbjct: 2582 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2641
Query: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1366
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 2642 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 2701
Query: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 2702 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 2760
Query: 1426 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 2761 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 2819
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1526
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 2820 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 2878
Query: 1527 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1560
+ + +ESQ E E ++ K E E + KQ+
Sbjct: 2879 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 2938
Query: 1561 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1593
+ Q LE + L + +RA Q+Q A
Sbjct: 2939 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 2998
Query: 1594 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650
L Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 2999 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3057
Query: 1651 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1698
+ + L RW+ N+A Q E VAQQ ++L EK+ E
Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117
Query: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3174
Query: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 3175 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3231
Query: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1869
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 3232 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3286
Query: 1870 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1923
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 3287 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3346
Query: 1924 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1971
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 3347 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3405
Query: 1972 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2024
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 3406 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3465
Query: 2025 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 3466 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3521
Query: 2079 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2133
+A + Q + +EL L + QS++ QL E E R+ EE + R
Sbjct: 3522 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3581
Query: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2189
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 3582 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3641
Query: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2246
D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E
Sbjct: 3642 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700
Query: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
+ ++++ + VQ KL + EN ++ +++ + E AEK +
Sbjct: 3701 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 3754
Query: 2306 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2359
+ + +R L + + +Q+ A + ++E++ +QE + +EL+
Sbjct: 3755 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 3814
Query: 2360 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
+ K + ++ L + + + + + ++A Q Q + A + + +
Sbjct: 3815 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 3874
Query: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
+++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L
Sbjct: 3875 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 3922
Query: 2476 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2523
+ + E E +K +Q E KL+ EE +Q +L AL Q ++L
Sbjct: 3923 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 3981
Query: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2579
+ + LL ++ + + +E E+AK L+ + Q +E + L+ S
Sbjct: 3982 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4037
Query: 2580 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2635
EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R
Sbjct: 4038 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4097
Query: 2636 LA 2637
LA
Sbjct: 4098 LA 4099
Score = 94.0 bits (232), Expect = 3e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1030
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 2892
Query: 1031 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 2893 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 2943
Query: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 2944 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3002
Query: 1143 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 3003 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3055
Query: 1203 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 3056 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3115
Query: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 3116 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3174
Query: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1379
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 3175 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3233
Query: 1380 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1423
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 3234 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3293
Query: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1477
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 3294 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3353
Query: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 3354 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3408
Query: 1538 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1586
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 3409 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3468
Query: 1587 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1622
+ V+ + +E E QS + +E+ QLER+
Sbjct: 3469 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3528
Query: 1623 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1664
L E ++QL E E QQQ E + RE E + +++
Sbjct: 3529 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3588
Query: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 3589 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3648
Query: 1724 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1777
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 3649 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 3708
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1832
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 3709 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 3758
Query: 1833 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 3759 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 3809
Query: 1889 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 3810 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 3857
Query: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 3858 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 3913
Query: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 3914 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 3971
Query: 2068 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
A + L +QK E EL + + VL + EA +A
Sbjct: 3972 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4030
Query: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 4031 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4077
Query: 2179 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 4078 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4135
Query: 2233 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4191
Query: 2289 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2337
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 4192 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4251
Query: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4310
Query: 2398 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 4311 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4362
Query: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2512
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 4363 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4404
Query: 2513 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 4405 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4464
Query: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2613
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 4465 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4524
Query: 2614 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2650
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 4525 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4571
Score = 85.1 bits (209), Expect = 1e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 1153 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1207
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 3342 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3386
Query: 1208 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 3387 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3446
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 3447 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3503
Query: 1325 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1370
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 3504 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3563
Query: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 3564 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3623
Query: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1482
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 3624 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 3682
Query: 1483 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1535
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 3683 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738
Query: 1536 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1585
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 3739 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 3797
Query: 1586 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
++ + + E E + + S E + + SL + EEA +
Sbjct: 3798 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 3856
Query: 1641 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1693
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 3857 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 3916
Query: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 3917 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 3968
Query: 1754 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1807
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 3969 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4028
Query: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 4029 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4078
Query: 1868 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1916
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 4079 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4138
Query: 1917 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1967
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 4139 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4196
Query: 1968 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 4197 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4249
Query: 2024 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2068
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 4250 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4309
Query: 2069 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 4310 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4367
Query: 2122 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 4368 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426
Query: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 4427 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4481
Query: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2284
++Q L + L + Q EE L+ EAE ++
Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541
Query: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2336
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 4542 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4601
Query: 2337 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2391
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 4602 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4661
Query: 2392 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2444
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 4662 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 4721
Query: 2445 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 4722 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 4775
Query: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 4776 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 4812
Score = 78.6 bits (192), Expect = 1e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 539 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 591
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 2970 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3029
Query: 592 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 3030 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3088
Query: 648 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 701
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 3089 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3148
Query: 702 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 740
+ G L + +R + Q+ L W +LQ C
Sbjct: 3149 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3206
Query: 741 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 789
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 3207 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3265
Query: 790 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 837
L Q DE +++L K + +AK + +QL R H H
Sbjct: 3266 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3325
Query: 838 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 891
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 3326 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3384
Query: 892 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 946
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 3385 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3444
Query: 947 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 990
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 3445 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3504
Query: 991 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1039
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 3505 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3564
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 3565 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3622
Query: 1100 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 3623 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3672
Query: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1213
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 3725
Query: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 3726 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 3784
Query: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 3785 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 3833
Query: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 3834 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 3885
Query: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 3886 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 3942
Query: 1453 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1503
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 3943 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4002
Query: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1562
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 4003 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4059
Query: 1563 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 4060 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4113
Query: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1660
++ E A + +EE + Q+ + AR E E +L
Sbjct: 4114 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4173
Query: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 4174 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4233
Query: 1721 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 4234 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4293
Query: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 4294 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4348
Query: 1837 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1890
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 4349 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4408
Query: 1891 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 4409 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4468
Query: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 4469 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4514
Query: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 4515 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4573
Query: 2070 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 4574 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4629
Query: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2177
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 4630 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 4688
Query: 2178 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 4689 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 4740
Query: 2237 QRLKAEATEAARQRSQVEEELFSVR 2261
Q++ A E R+ + + L +R
Sbjct: 4741 QQVWLLALERRRKLNDALDRLEELR 4765
Score = 69.3 bits (168), Expect = 8e-11
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1096
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 3892 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 3944
Query: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1152
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 3945 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4001
Query: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4052
Query: 1213 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1271
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 4053 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4110
Query: 1272 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1312
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 4111 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4170
Query: 1313 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1372
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 4171 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4224
Query: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 4225 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4273
Query: 1433 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1488
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 4274 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4333
Query: 1489 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1544
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 4334 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4393
Query: 1545 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 4394 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4449
Query: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 4450 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4492
Query: 1663 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 4493 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4551
Query: 1719 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 4552 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4611
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1830
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 4612 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4671
Query: 1831 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1880
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 4672 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 4731
Query: 1881 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1919
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 4732 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 4791
Query: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1978
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 4792 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 4850
Query: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
N + + ++E RQ+A + +R + E+
Sbjct: 4851 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 4887
Score = 64.3 bits (155), Expect = 3e-09
Identities = 34/98 (34%), Positives = 61/98 (62%)
Query: 417 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 476
RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 477 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 514
R DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
Score = 40.0 bits (92), Expect = 0.053
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 712 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
Query: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
+ E +F + Q KLK +E L+++ + EE
Sbjct: 771 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
Query: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 811 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
Query: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 870 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
Query: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 929 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
Query: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 989 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1039
Query: 2548 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 1040 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1085
Query: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145
Query: 2665 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2694
++ + +++ ++ LQ + A+
Sbjct: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1175
Score = 35.0 bits (79), Expect = 1.7
Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)
Query: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 450
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 4267 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4319
Query: 451 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 510
E+ D DK + + + Q +H + R L E+
Sbjct: 4320 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4365
Query: 511 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 562
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 4366 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4423
Query: 563 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 622
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 4424 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4478
Query: 623 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 668
+ +Q +L L+ SK A LR E HS V A L WL E E+ +
Sbjct: 4479 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4534
Query: 669 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 715
F D + + + M++LE K ++ + GD +L HP
Sbjct: 4535 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4583
Score = 35.0 bits (79), Expect = 1.7
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 4484 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 5067 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5117
Score = 32.7 bits (73), Expect = 8.5
Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)
Query: 532 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 584
+V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL
Sbjct: 4275 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4334
Query: 585 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 639
H+ +S+ + + L T A D L L ++ + S R
Sbjct: 4335 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4394
Query: 640 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 691
LE F T L WL E E++ D N+ +++ A +E
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4451
Query: 692 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 751
L + ++ L+ + L+ V+ L T+W + L + L+
Sbjct: 4452 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4511
Query: 752 FQFFSDVREA 761
+ F V A
Sbjct: 4512 AEEFHSVVHA 4521
>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
Length = 3062
Score = 787 bits (2032), Expect = 0.0
Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)
Query: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
Query: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
Query: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Query: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
Query: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
Query: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
Query: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
Query: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874
Query: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934
Query: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994
Query: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
Query: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
Query: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167
Query: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1481
++ ++++++ L++S +Q + ++ S +++EE++
Sbjct: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
Score = 124 bits (312), Expect = 2e-27
Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)
Query: 3688 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3746
E+YNLL E + L+E+ + +AG + + LS++QA+ +GL+ +
Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256
Query: 3747 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3804
LLE Q L+ P + + +A GL+ ++ +L LS + + P
Sbjct: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313
Query: 3805 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3864
TI + A+ + +I A+++L+ L+TG +V P G L L+ A+Q+ ++ ++
Sbjct: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
Query: 3865 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3921
E + + +DP T E++S +++R + TG LLP+ + ++T + + I++
Sbjct: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432
Query: 3922 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3981
++D T +L + L G G+ + +R++V +A++
Sbjct: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475
Query: 3982 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 4041
+G+I TA +L Q TG +I +LTV+EAV+ ++ +L A+R G
Sbjct: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535
Query: 4042 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4101
P+SG++ ++++ LI + ++L + + PE S + ++ A + G+ D
Sbjct: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595
Query: 4102 EMNEIL 4107
IL
Sbjct: 1596 NTASIL 1601
Score = 119 bits (298), Expect = 7e-26
Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)
Query: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 712 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770
Query: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
+ E +F + Q KLK +E L+++ + EE
Sbjct: 771 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810
Query: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 811 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869
Query: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 870 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928
Query: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 929 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988
Query: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
K+Q E + K+ Q QQ+ L+ E + ++QS + E ++ ++ +
Sbjct: 989 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046
Query: 2548 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2600
+ V Q+ +++R Q Q+ R R A + + A + ++R +EE
Sbjct: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106
Query: 2601 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2653
+ LE+++++ E E + + + L++ +A SEE++ + ++ L
Sbjct: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166
Query: 2654 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2712
+ L + E + L ++V LQE+ +L +E L++L + T+
Sbjct: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216
Query: 2713 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2772
DV+ + IAG + + T E LSV+ A+ R L+ T + LLE Q L+ P
Sbjct: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276
Query: 2773 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2830
+ + +A G++ ++ +L LS + + P T I + A+ + +I I
Sbjct: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333
Query: 2831 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2890
++LE ++TG ++ P ++ + A+++ + + + + K DP T E ++
Sbjct: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393
Query: 2891 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2950
+ +++R TG+ LLP+ + +GG + G+ ++
Sbjct: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431
Query: 2951 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3010
I LR G I E + +++ +
Sbjct: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451
Query: 3011 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3070
A+LL +I+ Q++ E V + DT L G+ ++L++ A
Sbjct: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511
Query: 3071 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3130
++ DL+ S A+ +LEAQ G +I P + +++ L+ E K+L+ + +
Sbjct: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571
Query: 3131 GYRDPYTGQSVSLFQALKKGLI 3152
P + Q + L A + G+I
Sbjct: 1572 ALYIPESSQVIGLDAAKQLGII 1593
Score = 109 bits (273), Expect = 5e-23
Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)
Query: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1998
VE L + V I ++S ++A + ++ L + L S+ L +R
Sbjct: 308 VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367
Query: 1999 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2056
+R L R E + + EEE A + R K E R ++ E
Sbjct: 368 QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427
Query: 2057 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111
QE A QL L A+ ++A + A+Q + + Q Q + + + E
Sbjct: 428 NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483
Query: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
A +EA R +++A + K S + R+ + E L +E+ +
Sbjct: 484 FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526
Query: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
E Q + A ++ + ++ L+ ++ ++++ + +
Sbjct: 527 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586
Query: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
L R K + + V F+V +E L RIE + + N
Sbjct: 587 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638
Query: 2292 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
E MK V + R S A L ++ L+ ++ E L++
Sbjct: 639 LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698
Query: 2344 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399
++ + T+L+ E + +Q + + A R +E +E + E + + LE
Sbjct: 699 ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757
Query: 2400 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2430
R Q ++ E ERLK + ++ +QA A
Sbjct: 758 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817
Query: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2490
R + + + +++ + + ++T+ + + + + EA+ +L E + +
Sbjct: 818 PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871
Query: 2491 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2546
+EA + + E +Q E +Q F + +D L Q+ + I E K +
Sbjct: 872 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930
Query: 2547 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2603
F KA QL E Q Q++ + L S++ R H ++ +++ + +++
Sbjct: 931 FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
Query: 2604 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2647
++ + + + LA E Q ++ Q EQ+ A + E T + V
Sbjct: 991 QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050
Query: 2648 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2701
+ + P R + A E F LR + +A Q ++ AG + L+RL +
Sbjct: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104
Query: 2702 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2750
+++E + E + + S+I+ L A + +K+S + +++ LS
Sbjct: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164
Query: 2751 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2791
I L + D RN L +E++K+ G V ++
Sbjct: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222
Query: 2792 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2851
KL ++ + G D TG+ +S+FQA+ +GLI + GIRLLE Q+ G+I P
Sbjct: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279
Query: 2852 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2911
+ A G DE++ L + S + + + T + +L+ + T + +
Sbjct: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335
Query: 2912 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2966
+ G LV + + +KA SA F K + ++I+
Sbjct: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395
Query: 2967 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 3026
D+++ R T+++ + + V QE GR+ + R+ + +IDRE
Sbjct: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444
Query: 3027 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3086
T+ R L + G+ +GQ++++ A+++ ++ D A ++L
Sbjct: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489
Query: 3087 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3146
Q TG II + RLTVDEAV+ L+ +L A++ G P++G+ +
Sbjct: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549
Query: 3147 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3198
L++ LI E ++L+ + + P S + LD A G +D T+ L
Sbjct: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
Score = 90.5 bits (223), Expect = 3e-17
Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)
Query: 3792 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3851
++ + G D T + +S+FQA+ + LI + +RLL+ QL G++ P L L+ A
Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
Query: 3852 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3910
G +++ QL E S+ + + ++ + L + + ++L L L
Sbjct: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
Query: 3911 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3970
+Q+T+++ + ++ A K LE + + T
Sbjct: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388
Query: 3971 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4030
E++S+ +++ ++ T LL + G I G +++ A G++ E +
Sbjct: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448
Query: 4031 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4090
LLSA+ G + SG+ +++ +A+++G+I +D +L Q+ TGGII + RL V
Sbjct: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
Query: 4091 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4149
+ A + L ++ + G P++ E T L + IT+ L
Sbjct: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564
Query: 4150 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4194
+ R++ + PE+ + + + A + G+ID+ T
Sbjct: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597
Score = 90.1 bits (222), Expect = 4e-17
Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)
Query: 4035 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4094
++ + G D +G+++S+FQA+ +GLI D GIRLLE Q+ G+I PE ++ A
Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
Query: 4095 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4144
GL DE++ EI++ S T D + +T ++ TG
Sbjct: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345
Query: 4145 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4192
++P L++ ++ SS S V +R+ + ++DP T +++S+ + ++ +
Sbjct: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405
Query: 4193 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4252
T + L + + +G I + GR I A + LIDR + + +
Sbjct: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451
Query: 4253 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4312
A +LSG G+++
Sbjct: 1452 -------AQLLSG-------------------------------------------GLIN 1461
Query: 4313 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4372
+ + +++++ EA+ ++D T +L Q TGGII + +R V +AV L+
Sbjct: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521
Query: 4373 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4432
+ AQ+ + G P + + +L++ + E + L + L P++
Sbjct: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581
Query: 4433 VPLDEALQRGTVDARTAQKLRDV 4455
+ LD A Q G +D TA L+++
Sbjct: 1582 IGLDAAKQLGIIDNNTASILKNI 1604
Score = 88.2 bits (217), Expect = 2e-16
Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)
Query: 3126 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3185
+K + G D TG+ +S+FQA+ +GLI + G+RLL+ QL G++ P L A
Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285
Query: 3186 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3245
+ G +DE+ L + +KA S P T +P+ + A+
Sbjct: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324
Query: 3246 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3303
+ E + + +P G + ++ L+SS F+ ++ + +
Sbjct: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384
Query: 3304 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3360
T EKV LI +V+ + +R L G + RA E L D
Sbjct: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442
Query: 3361 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3420
+T + LS LL G G+ ++ +++++ EA+R G++ TA+ +L Q
Sbjct: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
Query: 3421 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3480
TG ++ +RL V EAV+ ++ +L A++ G P+SG ++Q+
Sbjct: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552
Query: 3481 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3538
L+ + ++L + + P S + +D A Q G +L + + D
Sbjct: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612
Query: 3539 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3594
D +N R+ L C P T + E TTQ T EET++ F
Sbjct: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664
Score = 85.9 bits (211), Expect = 8e-16
Identities = 88/421 (20%), Positives = 179/421 (42%), Gaps = 39/421 (9%)
Query: 3349 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3408
+L +QL++ +T+ G V+ + +AG + T E +S+++A+ RGL+
Sbjct: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253
Query: 3409 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3466
T LLE Q L+ P + + +A G++ ++ QL LS K + P
Sbjct: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313
Query: 3467 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3526
+TI + A+ + ++ I++LE ++TG ++ P ++ + A+Q+ S +
Sbjct: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370
Query: 3527 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3586
+ + + K DP T E ++ +++R TG+ LLP++ E + T +
Sbjct: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRI--TLKCGR 1428
Query: 3587 EEETRRAFEETQID------------IPGG--GSHGGSTMSLWEVMQSDLIPEEQRAQLM 3632
RA E ID + GG S+ G M++ E ++ +I + + ++
Sbjct: 1429 NISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSIL 1488
Query: 3633 A-DFQAGRVTKERMI--IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLET 3689
Q G + + + + E ++ I L + R + +I +
Sbjct: 1489 TYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYV--------GLIWPHS 1540
Query: 3690 YNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARL 3749
+ + +E + E A+ L G +A +Y+P S Q + + A + G++ A +
Sbjct: 1541 GEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASI 1600
Query: 3750 L 3750
L
Sbjct: 1601 L 1601
Score = 81.3 bits (199), Expect = 2e-14
Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)
Query: 4007 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4064
+ + T+++A + G P F + +S+E T K+ S L I LF A K G + D
Sbjct: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182
Query: 4065 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4122
LE Q+ T +ES+ L + K+ + ++ + D G D T
Sbjct: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237
Query: 4123 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4182
E L+ Q + R + D TG+ LL +T S ++ PE K +
Sbjct: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282
Query: 4183 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4242
+A GLID Q +L E E I+ +S + + DA+A+++I
Sbjct: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328
Query: 4243 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4302
S ++I +LS + + + ++ + S A +S E
Sbjct: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375
Query: 4303 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4362
++D T EKVS+ + + R+ + TG LL + GG I G + A
Sbjct: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435
Query: 4363 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4422
++GL+D+ + R+ AQ G + + +M+ +A+++G + + L Q TG
Sbjct: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495
Query: 4423 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4482
G+I+ + R+ +DEA+Q + + +A + + L P + +L + ++
Sbjct: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555
Query: 4483 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4519
++L Q Y P S G A + G
Sbjct: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591
Score = 72.0 bits (175), Expect = 1e-11
Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)
Query: 3052 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3111
VIAG + G+ LS++ A+ + L+ D + LLE Q +I P + +A
Sbjct: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287
Query: 3112 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3169
GL+ + K LS K + P T + + AL + +I +++L+ LSTG
Sbjct: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344
Query: 3170 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3229
+V P+ ++ L A + + + + K DP T E + ++ QR
Sbjct: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404
Query: 3230 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3273
+ TG+ LLP+ + RA E L RET F ++ GG
Sbjct: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460
Query: 3274 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3319
G+ +TV E + + +L Q +TG ++TV++ ++ LIT
Sbjct: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520
Query: 3320 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3379
+ L +R + GL P S L ++L + K +L
Sbjct: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565
Query: 3380 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3415
G +A +Y+ ++ + + + A + G++ TA++L
Sbjct: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601
Score = 64.3 bits (155), Expect = 3e-09
Identities = 34/98 (34%), Positives = 61/98 (62%)
Query: 417 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 476
RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 477 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 514
R DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153
Score = 48.9 bits (115), Expect = 1e-04
Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)
Query: 1583 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637
E++R R VA L + + LQS+ F E + + + + + QL +E
Sbjct: 659 EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715
Query: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697
Q E ++ E E+E + L +E +RL+ E + + + Q ++++
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773
Query: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1754
E+ R +E+ ++ E + +L E Q AA + LR+E Q
Sbjct: 774 HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832
Query: 1755 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1810
Q + + + Q EA L K+ E E ++A K E ST +
Sbjct: 833 QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890
Query: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
+ + ++ + F L +E + +A+++E + + + D + +A+++ +
Sbjct: 891 QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943
Query: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
+ + + L++ E + L + D +Q + I+E + K
Sbjct: 944 RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002
Query: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
++L +QK LV + ++ +++E + E+ +A + EL+ R+ + +S
Sbjct: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056
Query: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050
++R++ + + +E + + A + K A + ++RL+ EE +
Sbjct: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108
Query: 2051 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2098
L E ++ E A++LQ K L+ EKA + + K+++L + LQ
Sbjct: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168
Query: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2156
Q L A+ + +E R + E++ Q + +E LKQ E Q
Sbjct: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
Query: 2157 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2215
+ + +K + +Q QA LR D
Sbjct: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255
Query: 2216 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2275
T +RL LE L+ EL+ K + A+ ++E++ Q++ELSK K I
Sbjct: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309
Query: 2276 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334
A + I + D + A K+ ++ L + A Q A + AL
Sbjct: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369
Query: 2335 AEKMLKEK 2342
K+L+ +
Sbjct: 1370 FSKVLERQ 1377
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 430 bits (1105), Expect = e-119
Identities = 555/2251 (24%), Positives = 912/2251 (40%), Gaps = 311/2251 (13%)
Query: 57 ERAVIR-IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 115
ER+ I+ +ADER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ L
Sbjct: 44 ERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEIL 103
Query: 116 PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 174
P+ KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI
Sbjct: 104 PKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQ 163
Query: 175 DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232
DI V + E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+
Sbjct: 164 DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLL 223
Query: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
D + + NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++
Sbjct: 224 DFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKM 283
Query: 293 PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 344
+ +G R A E + ++Y L LLQW+ +R+ +S ++
Sbjct: 284 KALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQ 343
Query: 345 WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 401
F ++ +E P K +K + + +++ ++A KV G D+ K W +L
Sbjct: 344 LQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLE 403
Query: 402 VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 458
A ERE LR+E R E L+++ + +A + E L++ L+ D + L A
Sbjct: 404 KAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAA 463
Query: 459 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 518
++ +E D I VQ + + Y + R+ R + ++
Sbjct: 464 VRKHEAIETD-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL 516
Query: 519 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 578
+ A + + LQ V + L YL D W+EE + R+ + G L V
Sbjct: 517 RQMVAARRERLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGV 566
Query: 579 EAQLGSHRGLHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQ 627
E L LH+ +E + + ER R+ L G YR C + +L+
Sbjct: 567 EDLL----QLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQS 622
Query: 628 Y---AKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 684
Y +L + +ARL L F+ + W+ E++ D T
Sbjct: 623 YEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNK 682
Query: 685 YSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAH 744
++AL E+ + +K G +L+ E HP + A LQ QW + L
Sbjct: 683 HTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQR 742
Query: 745 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 804
L + A+ +QF +D + E L +ALR S + + L + + +E++ +
Sbjct: 743 LAQAASLYQFQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSH 799
Query: 805 KGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPS 864
+ L L ++A A+ R P ++GR+P L
Sbjct: 800 RPTLDALREQAAALPPTLSRTP--EVQGRVPTL-------------------------ER 832
Query: 865 HWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLA 922
H++ L + E A A EA L LW + + LA
Sbjct: 833 HYEELQARAGERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLA 879
Query: 923 WQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 982
D+++++ F TL+PE A ++ A + G +DR++
Sbjct: 880 LPERLEDLEVVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNT 932
Query: 983 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 1042
+E +H +QQ + L G + S L LE ET+ R
Sbjct: 933 QE--QLNHRWQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR--------- 975
Query: 1043 ARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE 1102
E+ K +GLG +A + A K+ A EL
Sbjct: 976 ---------EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TR 1020
Query: 1103 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV------------- 1145
+ +L+A + + I+ +R Q E LRA EE L EA+ +
Sbjct: 1021 EANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAW 1080
Query: 1146 -------------PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1192
PATLPE EA A LR + E Q + LR +GE + +
Sbjct: 1081 LGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR 1133
Query: 1193 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252
+ D + R+R+ L W+ + + RQ L Q A +L+D
Sbjct: 1134 --DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRD 1180
Query: 1253 ARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1304
AR+ + + + S QA +++ + + ++ +GE++ +Q ++
Sbjct: 1181 ARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS 1240
Query: 1305 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364
E + K + + + + K Q ++ + D R Q+
Sbjct: 1241 -----EGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQD 1286
Query: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
L+ +E+ L Q + + R + +K + A K ++ KE
Sbjct: 1287 CHELKLWIDEKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE----- 1339
Query: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE-- 1479
E ++ + K + E+L+ L + E QAKAR A R+ L +
Sbjct: 1340 ------GRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCC 1393
Query: 1480 --EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
E + LQ + G + L + + E + ++E E ++ Q + +Q
Sbjct: 1394 ALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED 1453
Query: 1538 RQA-EVELASRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVA 1593
+ A EVE SR A EK RAL Q + E RLQA + + + + V
Sbjct: 1454 QGAGEVERTSR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTER 1507
Query: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAE 1648
L A + +K L++ +Q +A LRE A + AE +
Sbjct: 1508 LPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQ 1567
Query: 1649 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1708
+ ELE + +ALR AQQ AEAE E E + KA++
Sbjct: 1568 EMWKRLGHELELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKD 1619
Query: 1709 QAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ-------- 1751
+ Q E+ + Q LE+ T Q A+ Q++I R+ Q
Sbjct: 1620 ELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGL 1679
Query: 1752 ----GEQQRQLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEE 1804
GE++ +L E L +L+RE Q QE E A ++ + E + + + E
Sbjct: 1680 KELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREF 1739
Query: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864
SR TS ++R+++ L RA E K A D E +
Sbjct: 1740 SRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQ 1795
Query: 1865 KLAAIGEATRLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIE 1919
LAA E R A AL + + ++L R L EA QRR ++ DI+
Sbjct: 1796 VLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQ 1850
Query: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979
Q+++ D QK D + + + + A + ++A + +L L+
Sbjct: 1851 ALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD----- 1905
Query: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2039
D R +A R+ L +E + +A+ER + +A+ Q+ E
Sbjct: 1906 --TTDKFRF-----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE--- 1955
Query: 2040 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2099
++A+ + + ++ AR A+E ++K Q + + Q+ ++ Q+ +
Sbjct: 1956 -IEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWL 2009
Query: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159
Q VL+ L +A A + + E + +VE + ++ ++ A A +
Sbjct: 2010 QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERF 2069
Query: 2160 AAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
A EKL E+E R+ + E+ R++ A
Sbjct: 2070 CALEKLTALEEREKERKRKREEEERRKQPPA 2100
Score = 123 bits (309), Expect = 4e-27
Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)
Query: 1193 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252
R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL +
Sbjct: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443
Query: 1253 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1311
+R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++
Sbjct: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499
Query: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371
+ + + + V + E ++ ++L+ + +L L +++ + L+
Sbjct: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557
Query: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1429
+ LA + + L E + A++ +R A A A +E + Q + E V
Sbjct: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617
Query: 1430 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1474
+ E EA + +R+ EE ++L + +EA ++ + +A+ R
Sbjct: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677
Query: 1475 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526
LR E R+ L+L + Q+ AEG A +A A AE Q + ERL
Sbjct: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732
Query: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1576
++ +QR QA AS + +A+A + + AL +E QA +
Sbjct: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788
Query: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636
R + E+ R AL Q +A S+ + LER +E +
Sbjct: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847
Query: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1688
E A E+ Q AL RL+ EV QQ+ + A+
Sbjct: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907
Query: 1689 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1738
+ AE+ + +++ V +E ++ R+LA+G L
Sbjct: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967
Query: 1739 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1786
+ +R +T+ E + L L+ +LA +R+ A + EL E LA
Sbjct: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
Query: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1845
V + ++ R + + +R E G R L + L A + Q
Sbjct: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
Query: 1846 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1901
+A E+ EAE +LA+ A GE R ++E RLR L E D+A
Sbjct: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136
Query: 1902 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1941
F R+RLE E+ + + RLAQ LR A +E L Q+ ++
Sbjct: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196
Query: 1942 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2001
T ++ + A A+ +K + ++ RI E + + + A + R+
Sbjct: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
Query: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2061
A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR
Sbjct: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
Query: 2062 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2108
L +A+ AA K + + ++ EL+ + ++ L D+L
Sbjct: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370
Query: 2109 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2162
+A R+ +A A + A+ A + Q+ + K + Q
Sbjct: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430
Query: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ
Sbjct: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486
Query: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282
HQ + VE+E+ V ++ S ++ + + L+
Sbjct: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
Query: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2340
++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+
Sbjct: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585
Query: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
+ ++A Q+ R AEAE ++EL M Q+ A++
Sbjct: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619
Query: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
E+SA+AE K +V E + A + + +H+ ++Q+ +
Sbjct: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660
Query: 2461 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2516
+ ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ +
Sbjct: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720
Query: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
L Q + + + R++F E + + Q+ V A L L+
Sbjct: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762
Query: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2636
A AR E ++ + +L +L R Q +LA + LQ R AL
Sbjct: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814
Query: 2637 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2696
A + T N +AL EH L +V Q++Q+ G L
Sbjct: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866
Query: 2697 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2752
Q+ G +E+ R + LQG S+ LL T +K + A++ +L
Sbjct: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925
Query: 2753 ALILLEAQ 2760
+ ++AQ
Sbjct: 1926 VNLQMDAQ 1933
Score = 122 bits (307), Expect = 6e-27
Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)
Query: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
EL A +A+++K EA + A ++ V L ER +++R R
Sbjct: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508
Query: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
+ W L Q +RE L +L+ + L W+++ + R +Q+ L A
Sbjct: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564
Query: 1271 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1329
E L Q L+E +I E+V A ++ N K+Y +P +
Sbjct: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616
Query: 1330 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1374
K++ E++ + R E L Q++ ++T R +
Sbjct: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676
Query: 1375 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1430
RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + +
Sbjct: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735
Query: 1431 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
EE A Q Q + + LR S E+ +A R +EEE
Sbjct: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
Query: 1481 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540
IR R L+A Q L +R E + + + E L+ + +R R
Sbjct: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848
Query: 1541 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1584
E LA + +EA A EK++ L + LE+L R + E E A++
Sbjct: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
Query: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1644
+ L A + + + + + Q R + A+ + +
Sbjct: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967
Query: 1645 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
E + E + +E Q N+ A L LQ + ++ L A + E A
Sbjct: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027
Query: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1757
G + L E + + A ++ E Q+ +R + + G Q
Sbjct: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087
Query: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1813
+ EE EA A + L E+ + ++E L +A EE +R ++ +
Sbjct: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144
Query: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1869
QRLEA + EL RQ +LA+ + R +AE VL+ + +
Sbjct: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195
Query: 1870 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1917
T A+ A+K+ E A ER+ L E + + + KAD
Sbjct: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255
Query: 1918 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1960
IE R + + A+ L R Q+ ++D + ++E++L L
Sbjct: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315
Query: 1961 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016
++K A AEL L ++ + E TL E L + + R L RR E E
Sbjct: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371
Query: 2017 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Q + +A R Q ALE +E L+A++ + + L
Sbjct: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422
Query: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2130
+K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE
Sbjct: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479
Query: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
+ + E + + E+ + E+L + E + + Q +++ Q
Sbjct: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533
Query: 2191 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2242
E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R +
Sbjct: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593
Query: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2299
+AA + + E+ + Q + +L A+ E + ++ L D T L ++
Sbjct: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653
Query: 2300 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2349
M E+ R+S+ + A L++LA E L + L + + L + Q +QE
Sbjct: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713
Query: 2350 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2403
+ A EL Q + + +++ R D + Q+ + L A R
Sbjct: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773
Query: 2404 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2456
E + E+ +R Q A + QRF R+ + K + T +
Sbjct: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833
Query: 2457 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2510
+ L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q
Sbjct: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891
Query: 2511 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2563
L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ
Sbjct: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
Query: 2564 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620
+ ++E R + ++ E R H A E + E+L QL+ +R++ E E+
Sbjct: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008
Query: 2621 LREQLQLLEEQHRAALAHS 2639
L+ L++L A +A +
Sbjct: 2009 LQLVLEVLVFGRDAGMAEA 2027
Score = 115 bits (288), Expect = 1e-24
Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)
Query: 1175 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1230
ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L
Sbjct: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744
Query: 1231 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1289
Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H
Sbjct: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800
Query: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
++ + A A L P S + P+VQ ++ + Y +L+
Sbjct: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840
Query: 1350 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1399
E + + +EE+E+ LA +R E+ E + + LE +
Sbjct: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900
Query: 1400 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1457
A A + + ++ +V +E QQ R + + + S S
Sbjct: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960
Query: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1514
+ + +A R + ++ E + + L A +R+ G E +L+A+ AR E
Sbjct: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019
Query: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1573
R+A LA+ A+A A + R +Q E+LR
Sbjct: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051
Query: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1633
A R R+ + AR++Q L + + + R A + + +L E +AQ
Sbjct: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106
Query: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693
A + E ERA+ E R LR EEV + ++ Q +Q+
Sbjct: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146
Query: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
EA G E+ R E +Q +LA+ Q + +AE
Sbjct: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190
Query: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Q+ L E+ + A AA +K ++ + + + LL + + E ++K +
Sbjct: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250
Query: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
++ ++ R ++ + A + + + Q+ ++ + E++L + + EA
Sbjct: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310
Query: 1874 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
L T+ + + E A + L ++ ++ R L + + KA + E+L L + D
Sbjct: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366
Query: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
ELE T + R + + A +A + E LE + + +++D +
Sbjct: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
Query: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050
+ +Q+ L E R +E E ++ A+ +A Q EVER VEE R
Sbjct: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471
Query: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2090
+ +E R+LQ ++E Q E++ + +K Q
Sbjct: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531
Query: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
LQ+ +Q + + LR A AA E A +Q +R E E + E+
Sbjct: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586
Query: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2210
+A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ
Sbjct: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642
Query: 2211 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2263
+L + + +H ++ + ++ +L A E A R+R Q L +R +
Sbjct: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702
Query: 2264 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2305
+++L + + + A + L +LRDK +T QE + +A
Sbjct: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762
Query: 2306 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2342
AAR +VA Q A +L ++ALA ++ K
Sbjct: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820
Query: 2343 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2391
Q + + T A Q++ A E Q +++Q+D ++ + A E G
Sbjct: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Query: 2392 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2445
AE QL+ S+ A R L L + R E D + A+E +
Sbjct: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940
Query: 2446 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2491
+L + + + +E + + S + AE + E +++L+ + Q+
Sbjct: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997
Query: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2546
A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K +
Sbjct: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057
Query: 2547 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
FQ ++ ++ E+E++R EE RR+Q A E
Sbjct: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102
Score = 108 bits (270), Expect = 1e-22
Identities = 320/1501 (21%), Positives = 539/1501 (35%), Gaps = 266/1501 (17%)
Query: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1391
V E I YV HY + K I + L E ERL E+ + E L
Sbjct: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320
Query: 1392 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1440
+E + RQLA + + + Q E+ K ++ E ++ ++ + A
Sbjct: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380
Query: 1441 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1466
QK R I QE+L+QL ++ + +A R+
Sbjct: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438
Query: 1467 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1519
+E RL ++ + +EA R+ E G +QA+ A A E A++
Sbjct: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498
Query: 1520 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1574
+ + V RQ R+ E + Q L ++ + RLQ+++
Sbjct: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558
Query: 1575 AERRLRQAE----------------VERARQVQVA----------------------LET 1596
R L E ER R V + +
Sbjct: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618
Query: 1597 AQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------ 1648
++S EA EL + R + E++ +L R L E A A +RE+ A +
Sbjct: 619 LEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR 678
Query: 1649 ------RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1702
R E L +L + +L + A Q S AE + Q E E A
Sbjct: 679 LLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEE 738
Query: 1703 RGKAEEQAV------------------RQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1744
R + QA R ++ EL + A+Q A E+E+
Sbjct: 739 RAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
Query: 1745 LRAETEQGEQQRQLLEEELAR---LQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801
R + +Q L L+R +Q + +EL+A + +E LA
Sbjct: 799 HRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTML 858
Query: 1802 EE---------------------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE- 1839
E E E +QR E LA + + +AE+
Sbjct: 859 SEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918
Query: 1840 -----AKRQRQLAEEDAARQRAEAERVLAE-KLAAIGEATRLK------TEAEIALKEKE 1887
+ R + ++ R + R LA+ K AA+ A ++ TE + ++EK
Sbjct: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978
Query: 1888 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQ 1946
E + L D A A Q K ER + A EL R+ L Q
Sbjct: 979 KVIESTQGLGNDLA------GVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQ 1032
Query: 1947 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2006
+ + ++ +E A E LG R +D LRS + + R + A E
Sbjct: 1033 AVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVASE 1091
Query: 2007 E--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------LRERA 2055
E EAE + + A E R A E RL+A EE R LR+R
Sbjct: 1092 EGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147
Query: 2056 EQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QLRGEA 2110
E +L + E+ Q RL +AH F + ++ + L ++ VL ++ G
Sbjct: 1148 EALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTL 1204
Query: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170
+AA A ++ E+ + ER+ E Q ++ A+K+R++A+
Sbjct: 1205 QAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIREKAD 1254
Query: 2171 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230
RR + Q A +Q + + + F + K +++++ T Q D +N
Sbjct: 1255 -SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYDEARN 1311
Query: 2231 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290
L + Q+ +A E A + +++ R E +LKA + + LRD
Sbjct: 1312 -LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDLHRRW 1365
Query: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKMLKEK 2342
L+ + + +A R + AQ L QL +D + +LK++
Sbjct: 1366 DELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQ 1425
Query: 2343 MQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQRTLE 2396
E + E E +Q Q K LAQE + R E+ + L + + R L+
Sbjct: 1426 QMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ 1485
Query: 2397 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2456
A R+ Q + + E L V E + E G+ L +L ++ T
Sbjct: 1486 ASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMKKNQT 1532
Query: 2457 LVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2508
L + + +++ +Q A +AEL+ ++L E L+L+ + ++ +
Sbjct: 1533 LQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLEDALR 1589
Query: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568
Q A ++++ E Q + QEKAK E Q EV K Q L + Q +
Sbjct: 1590 AQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTI 1644
Query: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2628
Q L AS ++ +H + +Q ++ +L + EL E +RL+E L+L
Sbjct: 1645 HQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEHLRLC 1697
Query: 2629 E 2629
+
Sbjct: 1698 Q 1698
Score = 77.4 bits (189), Expect = 3e-13
Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)
Query: 1000 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1057
E+ E R Q + L D + L +T ++ PA E +A+ +
Sbjct: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111
Query: 1058 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1111
EVE +RL A E+V + P LR LE LG++ + R
Sbjct: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167
Query: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1171
L + +R + AE VL + E L + +P TL +A A++KKL E
Sbjct: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219
Query: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L +
Sbjct: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273
Query: 1232 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1289
L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ +
Sbjct: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329
Query: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1343
K +++ + +L K +L+ + S + ++++ +++ +
Sbjct: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
Query: 1344 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1400
D +++ +++ + L + + L +++++ E E A+ EK+
Sbjct: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
Query: 1401 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1447
+ +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++
Sbjct: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499
Query: 1448 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1502
E+ ++L +S E + + +++EI+ ++ + ERQR L
Sbjct: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554
Query: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1561
A A E AE Q E +RL +++ +R A + R AEAEA +Q
Sbjct: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609
Query: 1562 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1614
+A +EL QAE + + L QA + A+ + ++Q + E +S R S +
Sbjct: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
Query: 1615 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1661
+ A R +EH+ + QLR E + Q Q+ E A E ++ E
Sbjct: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729
Query: 1662 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1702
+ ++ + Q++ +LA AE + EA +
Sbjct: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789
Query: 1703 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
RG+ A QR L A Q L KQ+QL +GT + AAE L R E
Sbjct: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848
Query: 1753 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1808
Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T
Sbjct: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906
Query: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868
++K + +A R L + L+ A+E R A+ Q+ + A A
Sbjct: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960
Query: 1869 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1924
++ + E+ + A E +L++ +A RR+ + Q K D + E L
Sbjct: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018
Query: 1925 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
R A +E L Q+ LV L E ++ +F+K+A E R
Sbjct: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070
Query: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
A + L + E+ E +E +R+RE EER ++ A E A+
Sbjct: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 413 bits (1062), Expect = e-114
Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)
Query: 421 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 480
L ++ +LQ A E+ + +A +QSD+ L G+ P+ + + ++ ++ +L
Sbjct: 27 LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
Query: 481 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 540
D K +HPQG+ + + +L ER+ +R ++ Q+ ++ ++ V
Sbjct: 87 ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
Query: 541 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600
P++ + L VEE +++ +G DLP V+ Q+ H H ++ +
Sbjct: 134 -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
Query: 601 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660
+ E L +Y KLL +S+AR + L SL ++ T EL WL+
Sbjct: 184 KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
Query: 661 EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 719
++ + + +DWSDRN + +++ Y + R LE KE++I +L + GD+LL +HP R +
Sbjct: 231 QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
Query: 720 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 779
+E+ A+ W L L C E+HLK Y QF DV++A+ L+K+ L +KY D
Sbjct: 291 IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
Query: 780 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 839
++E LL++ D+++ L++Y+ + GL KR + VV LK R P++ +P+ A+
Sbjct: 351 FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
Query: 840 CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 899
CD++ + + +G L S W+++ S+G++ P+VCF++PP
Sbjct: 408 CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
Query: 900 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 959
D ++L SL + +R + + RTL +QR + E
Sbjct: 455 ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
Query: 960 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1019
D+ D G +QLL L++ A + R ++ I+ +
Sbjct: 497 -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
Query: 1020 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1078
LR PL++ A ++ A+R + + E+ + R +AE E +
Sbjct: 529 --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
Query: 1079 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1138
S P LR+ +E T K E + L + EK+ + + + Q + E+L HE
Sbjct: 575 QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
Query: 1139 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1198
L + VP + L++ L + + +AQ+ + L+ A++ L R E
Sbjct: 635 LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
Query: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1258
++ER V +L +R+ + Q + R + L+ ++ D + +L +
Sbjct: 695 PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
Query: 1259 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1317
Q DS + E +L+ ++ LL+EI ++V++ ++QY A+KDYEL+ +
Sbjct: 755 Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
Query: 1318 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1373
+ L+ + +K+ ++QS + V +E L ++E+ + Q ++ + L + +
Sbjct: 810 SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
Query: 1374 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1424
+ + +R R + VE A + +++L E + + Q E E K Q+ +
Sbjct: 870 QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
Query: 1425 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1465
QE VVR+E + Q + + +QEEL+ L+ Q E + +
Sbjct: 929 QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
Query: 1466 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1514
E + LRIE +E+ +R +LEA RQ+G E E+ L+ R E++ A
Sbjct: 989 GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
Query: 1515 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569
Q++ ++E +L+ Q E+ Q Q + +L + + E ++K L+ LE+ R
Sbjct: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
Query: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1627
AE +VE+ + + R E E RAS EKT L + +L+EE+
Sbjct: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
Query: 1628 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
V ++RE E + E ER AE +L +Q + EALR R
Sbjct: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
Query: 1675 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733
EV + K + + + + + E+ + R + + + + +L +L+K+ Q + T
Sbjct: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
Query: 1734 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1787
Q E QE+++ + + + E+ + +L EE+ ++ E A+Q+ Q E
Sbjct: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
Query: 1788 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1844
R + V+ R EEE +E S + ++ E + +L E RL+ E +RQ
Sbjct: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
Query: 1845 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1896
+L E AR+ AE E + L ++LAA+ EA T + + +++ + R L RL
Sbjct: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
Query: 1897 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1956
+E RR+L E + + +LA L KA E++ + L E ++ E+EI
Sbjct: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
Query: 1957 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 2014
LK+S E+ + K EL++E+ R+ + + SK EL+ R+ + ER+ + E
Sbjct: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
Query: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2073
R L +E A L + + RL E + ++L ++
Sbjct: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
Query: 2074 LQAEEKAHAFAVQQKEQELQQTL 2096
LQ + A +Q+E L++++
Sbjct: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
Score = 187 bits (476), Expect = 2e-46
Identities = 338/1485 (22%), Positives = 609/1485 (41%), Gaps = 254/1485 (17%)
Query: 1395 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1454
AL L + + +A + LQQR EV++ E + Q R + L ++
Sbjct: 459 ALALADSLGSQYRSVRQKAAGSKRTLQQRY--EVLKTENPGDASDLQGRQLLAGLDKV-- 514
Query: 1455 SSEAEIQAKA---------RQAEAAERSRLRIEEEIRVVR--LQLEATERQRGGAEGELQ 1503
+S+ + Q KA Q A + S R ++ + L++E E+ R AEGE
Sbjct: 515 ASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEP-EKTRSTAEGE-- 571
Query: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
A Q LR +V+D + RK + ++L + + + A +++LQ
Sbjct: 572 --------AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQ 622
Query: 1564 ALEELRLQAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622
EL E L Q + V + +V + + ELQ++++ E L+ +
Sbjct: 623 QSWEL---LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAA 679
Query: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1682
Q ++ +E +Q+AE + + LR Q E AQ
Sbjct: 680 KQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSL 725
Query: 1683 SLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1739
A+A E + + + E Q E +L+ Q+ L + A + E
Sbjct: 726 QSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----E 781
Query: 1740 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1799
QE+ ++ A ++Q +Q K ELEAE + ++E +S
Sbjct: 782 QEVQKICANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHV 822
Query: 1800 RAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
+S + K K+ A A +F E+ A RL+ L RQ E + + +
Sbjct: 823 SKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQR 882
Query: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918
R + + EA +++ KE + E ER R+L + + + Q +
Sbjct: 883 NR----PDSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQES 931
Query: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKA 1969
R L+K D LE ++ TL + + ++EE+ AL+ E G+
Sbjct: 932 VVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991
Query: 1970 ELELELGRI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026
+ E+ RI R+ A++ L+ +E ELEA R+++ A E AE
Sbjct: 992 YVVKEVLRIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVL 1032
Query: 2027 AARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2085
+QR AAL EE R + KV E ++ + + + + Q QE Q++ Q EK
Sbjct: 1033 LLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK------ 1086
Query: 2086 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAER 2143
+E+EL LQ + L++ R AE E + E ERE + RQ E EA +
Sbjct: 1087 --QEEELS-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAK 1143
Query: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------Q 2188
+ S E+ + + A E+ K QE R +A++E A LR + +
Sbjct: 1144 ARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYR 1203
Query: 2189 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2248
A+ ++ ++ E R+ QVE + T + +TD + +++ELQRL+ E + R
Sbjct: 1204 GAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTR 1260
Query: 2249 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2308
+ + E++ ++ +++ L K +++ K+ Q LQ + + Q EE A
Sbjct: 1261 LIERCDLEIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVA 1309
Query: 2309 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2368
L E Q + DL ++RA E+ + K E EL + ++ + Q+
Sbjct: 1310 SLRAKLSE----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQ 1353
Query: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2428
+ R +E+ L E F +++ E ++ ++ AE RL+ R E+ R E
Sbjct: 1354 EVVRYEEEPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELER 1408
Query: 2429 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2488
+ Q R++++ + +RL++ +A LE+E+ +
Sbjct: 1409 ERQA--------------------------------RREAEREVQRLQQRLAALEQEEAE 1436
Query: 2489 LQQEAKLLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2546
+++ Q + ++ Q ++ LL+ LQ + LL+ E +E + KL L
Sbjct: 1437 AREKVTHTQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAAL 1490
Query: 2547 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-- 2604
+ EV + L E Q ++ EQE QRL +S+EE R + E + V R + L +LE
Sbjct: 1491 EKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFH 1550
Query: 2605 -QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2663
+ ++ + L EEN +L+ + Q L+ + R + +AAT+T RD +
Sbjct: 1551 NSKSSKELDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMT 1600
Query: 2664 AAEAEPEHS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ 2720
A++ H L R++ +RL + L +ELQ+ G V +RE ++L
Sbjct: 1601 VADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL- 1654
Query: 2721 GRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLL 2767
R SI ++ T +LS A R L + L +Q S +
Sbjct: 1655 -RRSIV-VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIH 1711
Query: 2768 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2812
D ++ ++ EA++ G + P + + ++ + ++ +GQ+
Sbjct: 1712 DRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
Score = 85.1 bits (209), Expect = 1e-15
Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)
Query: 4156 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4215
K + + +R +V++ P+TG+E+S EA+R GLID +++L QEC+WEEI++ +G
Sbjct: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
Query: 4216 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4265
S+I DR+SG+++ I++A+ + + D+Y +SI E A ++SG
Sbjct: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 404 bits (1037), Expect = e-111
Identities = 578/2481 (23%), Positives = 1025/2481 (41%), Gaps = 320/2481 (12%)
Query: 57 ERAVIR-IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 115
ER+ I+ +ADER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ L
Sbjct: 41 ERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL 100
Query: 116 PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 174
P+ KGRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI
Sbjct: 101 PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ 160
Query: 175 DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232
DI V + E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LI
Sbjct: 161 DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLI 220
Query: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
D +K+ + NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++
Sbjct: 221 DFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKM 280
Query: 293 PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 344
+ +G R A E + ++Y L LL+W+ R+F +S ++
Sbjct: 281 KALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQ 340
Query: 345 WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 401
F ++ +E P K +K + + +++ ++A KV G D+ K W +L
Sbjct: 341 LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 400
Query: 402 VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 458
A ERE LR+E R E L+++ + +A + E L++ L+ D L A
Sbjct: 401 KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 460
Query: 459 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEY 515
++ +E D+ + ++ + + L+ + +++ R V RL E L+ +
Sbjct: 461 TKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRAR 520
Query: 516 NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 575
RL+ + LQ + + + Y+ D W++E + V ++G L
Sbjct: 521 RQRLEMNLG----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHL 560
Query: 576 PSVEAQLGSHRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQY 628
VE L H + + + A ++ +D P RD + ++ Y
Sbjct: 561 LGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCY 620
Query: 629 AKLLN---SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 685
+L +ARL L F +E W+ EKE+ D+ T++ +
Sbjct: 621 QELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKH 680
Query: 686 SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 745
A E+ + ++ G+ ++ E+H + ++ QW+ + QL + L
Sbjct: 681 RAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRL 740
Query: 746 KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 805
+E + QF +D + + + + L+ S D + L++ +D E++ Y+
Sbjct: 741 EEASLLHQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYR 797
Query: 806 GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT---------------- 848
L L ++A A+ Q P +RGRL + YK+V E+T
Sbjct: 798 PTLDTLHEQASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKM 854
Query: 849 VHKGDECQL------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQE 894
+ D C+L P + +V+ E + + V NQ A++
Sbjct: 855 FSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ 914
Query: 895 AV-------TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLAT 940
+ ++AQ L T W Q VD K S L+ Q+ + +SW
Sbjct: 915 LMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREK 974
Query: 941 FRTLKPEE------------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 982
+ ++ + + L ++E ++++ P+
Sbjct: 975 TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAIL 1034
Query: 983 REYGSCSHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 1039
S ++++ L++ E E S+ Q+ + +L D + L +T
Sbjct: 1035 SRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-------- 1086
Query: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSE 1093
+ + + E +K + E + + + +K+ + E T LR
Sbjct: 1087 ---SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQR 1143
Query: 1094 LE-LTLG--KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1150
L+ L G +L ++ L + +R T+ AE L E L + +P T
Sbjct: 1144 LQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT-- 1200
Query: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
LE +A++KK E T DA +++ E G RL + ++ +R +E+V
Sbjct: 1201 -LEGAEAAIKK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDS 1252
Query: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
+ +R + L+ R L+ + + L W+ + + Q M +++
Sbjct: 1253 IDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARN 1308
Query: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AK 1328
+ + + QA + E+ + K++++ I+ +QL++ K + E V
Sbjct: 1309 LHSKWLKHQAFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTG 1357
Query: 1329 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER 1388
K+ ES Q R + L +Q + + L +E ++ Q + +
Sbjct: 1358 LHKMWEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKD 1411
Query: 1389 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQ 1446
L V L+KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q
Sbjct: 1412 LTSVNILLKKQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQ 1464
Query: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQA 1504
+ +L + E + +R +E+EI V R+ L AT G LQ
Sbjct: 1465 TKFMELLEPLNERKHNLLASKEIHQFNR-DVEDEILWVGERMPL-ATSTDHG---HNLQT 1519
Query: 1505 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
++ ++ + +++ Q R + D +R + + +S AEA R++ L+
Sbjct: 1520 VQLLIKKNQTLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQ 1572
Query: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
L L + EE E+R R+ E E R Q + A+ AEA + + E E +
Sbjct: 1573 LWGLLI--EETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAK 1622
Query: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1684
+E AV+ L++ + E+ +E + AE V Q
Sbjct: 1623 DEQSAVSMLKK---------------HQILEQAVEDY-------------AETVHQLSKT 1654
Query: 1685 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLA 1737
++A E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++
Sbjct: 1655 SRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWI 1714
Query: 1738 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1797
AE+E++ E Q + +L+E R+ Q+R + LA E++ +
Sbjct: 1715 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSG 1769
Query: 1798 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857
+ A +T + K L EL + ++ A + E + A+E R + +
Sbjct: 1770 HSDA-----ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-D 1823
Query: 1858 AERVLAEKLA----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1913
+ L E+L + R+ T E + +A ++R+L ED A RL+ A
Sbjct: 1824 KHKKLPEELGRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAG 1876
Query: 1914 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
KAD ++K + LE K L+ D RR + F +E
Sbjct: 1877 DKAD------DIQKRENEVLEAWKSLL-DACESRRVRLVDTGDKFRFFSMVRDLMLWMED 1929
Query: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQR 2031
+ +I A++ R EL + + AE + R ++ KSL AR+
Sbjct: 1930 VIRQI--EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKH 1982
Query: 2032 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2091
A+ E E+L E+ + + ++ E + L+L E Q A A A+ + Q+
Sbjct: 1983 YASEEIKEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYL 2040
Query: 2092 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ- 2146
+ + Q +++L EA ++A +E ER E + RRQ EE ER ++
Sbjct: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRP 2100
Query: 2147 -SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
S E + +A++ + + EQ + AEQ + R + D
Sbjct: 2101 PSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT------------- 2147
Query: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265
+++ T R +E+ + + + A AA ++ +E + QME
Sbjct: 2148 ---SEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQME 2201
Query: 2266 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2325
K EA N+ R N + + + A+ A A+ + +E
Sbjct: 2202 GFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYHSE 2252
Query: 2326 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2385
++ + A+ E L K + RL E L Q K+ +E +Q ++
Sbjct: 2253 VPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSDKH 2311
Query: 2386 EETQGFQRTLEAERQRQLEMS 2406
E + Q T + R + L S
Sbjct: 2312 EVSASTQSTPASSRAQTLPTS 2332
Score = 104 bits (259), Expect = 2e-21
Identities = 340/1836 (18%), Positives = 710/1836 (38%), Gaps = 258/1836 (14%)
Query: 1007 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1066
S QR +S+ + L A E T + D E Q + + + E E
Sbjct: 439 SENQRLVSQ-DNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR-ELEAENY-HD 495
Query: 1067 VARLSAEAEKVLALPE---PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI- 1122
+ R++A + V+ L E A R E+ L L K+ Q +++++K + L
Sbjct: 496 IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQD 555
Query: 1123 --RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF-DALRDE 1179
+ G E++L+ H L EA + + AS +K E +P +RD
Sbjct: 556 YGKHLLGVEDLLQKHT--LVEAD-IGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR 612
Query: 1180 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1239
+ + + L Q ER +E R L ++ +A+ + RE E++
Sbjct: 613 VAHMEFCYQELCQLAAERRARLEESRR-----LWKFFWEMAEEEGWIREKEKI------- 660
Query: 1240 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299
S+D G L R L+ +A +++ E+ + GE + + F
Sbjct: 661 -LSSDDYGKDLTSVMRL--------LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG 711
Query: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359
+ I++ + + A LE +++ KK ++ Q D ++
Sbjct: 712 SE---KIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD------DIDAWMLD 762
Query: 1360 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1419
+K +S + +E + Q ++ + +AE A A A Q E+ +
Sbjct: 763 ILKIVSSSDVGHDE---YSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPD 819
Query: 1420 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1479
++ R+ R +E A + +K+++Q+ L + SEA+ + + ++I E
Sbjct: 820 VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 879
Query: 1480 ---EIRVVRLQLEATERQRGGAEGELQALRARAEE-------AEAQKRQAQEEAERLRRQ 1529
++ V++ + E+ E + + + A + +E + + Q++ Q
Sbjct: 880 KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 939
Query: 1530 VQDESQRKRQAEVELASRVKAEAEA------AREKQRALQALEELRLQAEEA---ERRLR 1580
++ RK+ A + S E REK + +++ ++L +R+L
Sbjct: 940 FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 999
Query: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREE 1636
E + ++ L Q+ AE +L+S+ A+ + A++ + EE + RE
Sbjct: 1000 GMERDLVA-IEAKLSDLQKEAE-KLESEHPDQAQAILSRLAEIS-DVWEEMKTTLKNREA 1056
Query: 1637 AERRAQQQAEAERAREEAERELERWQLKA---------NEALRLRLQAEEVAQQKSLAQA 1687
+ A + + R ++ + L R Q EA +L Q E + + +
Sbjct: 1057 SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEE 1116
Query: 1688 EAEKQKEEAEREARRRGKAEEQAVRQR---------ELAEQELEKQRQLAEGTAQQRLAA 1738
+ +K ++ E + + A+ +RQR EL + +Q L++ A Q+
Sbjct: 1117 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1176
Query: 1739 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
+ + +AE Q+ L E+ A AA +K+++ + ++ ++ +
Sbjct: 1177 DTK----QAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETG 1232
Query: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
R + S++ ++++++ R R+ E A+ L ++ + ++ ++
Sbjct: 1233 RRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN 1292
Query: 1859 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
E++L + + EA L ++ A + A N+ E E Q L + + +A
Sbjct: 1293 EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ---LISEKPETEA 1349
Query: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
++E+L L K + + L Q + + L E A+L+ L
Sbjct: 1350 VVKEKLTGLHK------------MWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH 1397
Query: 1977 RIRSN--AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2034
+ S ++D + + +Q+ L + E R++E EE L ++ +A Q +
Sbjct: 1398 GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE-----LQSQAQALSQEGKS 1452
Query: 2035 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------------- 2080
+EV+ + V+ E L ++E Q E++
Sbjct: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512
Query: 2081 HAFAVQ------QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
H +Q +K Q LQ+ +Q Q +D + E ++ ++ +A R+
Sbjct: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI---FERSQNIVTDSSSLSAEAIRQRLAD 1569
Query: 2135 RRQ-----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
+Q +EE E+ + EE +A+ AAE +EQE ++ + + +Q+
Sbjct: 1570 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA---KDEQS 1626
Query: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATE 2245
A + ++KH+ EQ + A+ +L+ L H ++ + ++ +L A +
Sbjct: 1627 AVSMLKKHQ-ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1685
Query: 2246 AARQRSQVEEE---LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302
A +R +E LF + ++++L + A E + L LQE + ++
Sbjct: 1686 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE---RFRE 1742
Query: 2303 VAEEAARLSVAAQEAARLRQLAEE----------DLAQQRALAEKMLKEKMQAVQEATRL 2352
A + ++ + + LA+E +A+ + + + ++ + T++
Sbjct: 1743 FARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI 1800
Query: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA------EETQGFQRTLEAERQ------ 2400
A + L + A+E R+Q+ +++ ++L E Q T E + Q
Sbjct: 1801 LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV 1860
Query: 2401 RQLEMSA----------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR---- 2446
RQL+ A +A+ ++ R E+ A + + R + + G+K
Sbjct: 1861 RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV 1920
Query: 2447 -----------TELATQEKVTLVQTLEI-----QRQQSDHDA------------------ 2472
++ QEK V ++E+ Q +++ DA
Sbjct: 1921 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980
Query: 2473 -----ERLREAIAEL-EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
E ++E + +L E+ KE K + + L+L E Q + + + Q+ +L
Sbjct: 1981 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040
Query: 2524 S---------EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574
S E + L++R E+ A ++ F + + L + R+QQ+ E+ER+R
Sbjct: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKR 2098
Query: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHR 2633
S E + + EAE Q++ + ++ Q L AE+ + R+ E + E +
Sbjct: 2099 RPPSPEPSTKVSEEAE-----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNG 2153
Query: 2634 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2669
A + +S + + + + AL +A P
Sbjct: 2154 ATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLP 2189
Score = 103 bits (257), Expect = 4e-21
Identities = 323/1633 (19%), Positives = 650/1633 (39%), Gaps = 190/1633 (11%)
Query: 1050 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1109
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734
Query: 1110 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1168
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793
Query: 1169 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1225
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841
Query: 1226 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1284
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897
Query: 1285 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1344
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955
Query: 1345 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1395
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
Query: 1396 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1452
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068
Query: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128
Query: 1513 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1566
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188
Query: 1567 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1621
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248
Query: 1622 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1669
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307
Query: 1670 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363
Query: 1727 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1778
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423
Query: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475
Query: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1889
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530
Query: 1890 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1945
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583
Query: 1946 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 2002
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638
Query: 2003 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2060
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698
Query: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2119
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758
Query: 2120 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176
A+E +AA + E R Q AA+ +L K
Sbjct: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814
Query: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236
K+ +KHKK E+ R + VE TL+ +H L ++
Sbjct: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVE----TLQRMHTTFEHDIQALGTQV 1860
Query: 2237 QRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEA-ENRALILRDKDNTQRFLQ 2294
++L+ +A A Q + ++ ++ + E L K+ ++A E+R + L D + RF
Sbjct: 1861 RQLQEDA--ARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1918
Query: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--TRL 2352
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T +
Sbjct: 1919 MVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTTCI 1971
Query: 2353 KAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409
+ LL ++ E +E+ +L E +++M + + + + LE + + AEA
Sbjct: 1972 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2031
Query: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQ 2466
L SR ++ ++ ++ K+ E EK T + E++T ++ LE++RQ
Sbjct: 2032 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVRRQ 2090
Query: 2467 QSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521
Q + + +R E ++ E E QQ +K Q+ + Q + ET
Sbjct: 2091 QEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD---- 2146
Query: 2522 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRLVA 2577
SE + +R +E + + D AK AQ R Q+ A
Sbjct: 2147 -TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS-------A 2198
Query: 2578 SMEEARRRQHEAE 2590
ME R+HE E
Sbjct: 2199 QMEGFLNRKHEWE 2211
Score = 100 bits (249), Expect = 3e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 1193 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440
Query: 1253 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1302
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498
Query: 1303 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1360
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556
Query: 1361 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615
Query: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1478
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668
Query: 1479 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723
Query: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1596
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773
Query: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826
Query: 1657 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1710
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885
Query: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1765
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945
Query: 1766 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000
Query: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1881
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049
Query: 1882 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1935
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109
Query: 1936 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1982
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168
Query: 1983 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2038
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219
Query: 2039 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2094
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279
Query: 2095 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339
Query: 2151 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199
+ + +A E L + +A R A +A L + AD + H
Sbjct: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397
Query: 2200 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455
Query: 2257 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2309
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515
Query: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562
Query: 2370 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2425
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622
Query: 2426 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2476
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680
Query: 2477 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737
Query: 2533 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2572
ERF I QE+ DE +A+ + E ++ R
Sbjct: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797
Query: 2573 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2629
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857
Query: 2630 EQHR 2633
Q R
Sbjct: 1858 TQVR 1861
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 397 bits (1021), Expect = e-109
Identities = 535/2254 (23%), Positives = 947/2254 (42%), Gaps = 290/2254 (12%)
Query: 62 RIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KG 120
++ DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+ KG
Sbjct: 34 QLQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKG 93
Query: 121 RMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSG 180
RMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V
Sbjct: 94 RMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVET 153
Query: 181 QS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVY 238
+ E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K+
Sbjct: 154 EDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLK 213
Query: 239 RQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-D 297
+ NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ + +
Sbjct: 214 KSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVE 273
Query: 298 GVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLK 350
G R A E + ++Y L LL+W+ R+F +S ++ F
Sbjct: 274 GKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNT 333
Query: 351 FKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILER 407
++ +E P K +K + + +++ ++A KV G D+ K W +L A ER
Sbjct: 334 YRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHER 393
Query: 408 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGE 464
E LR+E R E L+++ + +A + E L++ L+ D L A ++
Sbjct: 394 ELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEA 453
Query: 465 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKA 521
+E D+ + ++ + + L+ + +++ R V RL E L+ + RL+
Sbjct: 454 IETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEM 513
Query: 522 GVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 581
+ LQ + + + Y+ D W++E + V ++G L VE
Sbjct: 514 NLG----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDL 553
Query: 582 LGSHRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN- 633
L H + + + A ++ +D P RD + ++ Y +L
Sbjct: 554 LQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQL 613
Query: 634 --SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRE 691
+ARL L F +E W+ EKE+ D+ T++ + A E
Sbjct: 614 AAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDE 673
Query: 692 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 751
+ + ++ G+ ++ E+H + ++ QW+ + QL + L+E +
Sbjct: 674 MSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLL 733
Query: 752 FQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL 811
QF +D + + + + L+ S D + L++ +D E++ Y+ L L
Sbjct: 734 HQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTL 790
Query: 812 AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDE 854
++A A+ Q P +RGRL + YK+V E+T + D
Sbjct: 791 HEQASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADA 847
Query: 855 CQL------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEAV---- 896
C+L P + +V+ E + + V NQ A++ +
Sbjct: 848 CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGH 907
Query: 897 ---TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKP 946
++AQ L T W Q VD K S L+ Q+ + +SW + ++
Sbjct: 908 PSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIES 967
Query: 947 EE------------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSC 988
+ + L ++E ++++ P+
Sbjct: 968 TQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEI 1027
Query: 989 SHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1045
S ++++ L++ E E S+ Q+ + +L D + L +T + +
Sbjct: 1028 SDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SED 1076
Query: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTL 1098
+ E +K + E + + + +K+ + E T LR L+ L
Sbjct: 1077 MPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDT 1136
Query: 1099 G--KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1156
G +L ++ L + +R T+ AE L E L + +P T LE +
Sbjct: 1137 GWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAE 1192
Query: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216
A++KK E T DA +++ E G RL + ++ +R +E+V + +R +
Sbjct: 1193 AAIKK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHR 1245
Query: 1217 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1276
L+ R L+ + + L W+ + + Q M +++ + +
Sbjct: 1246 KNRETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNLHSKWL 1301
Query: 1277 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKKPKVQS 1334
+ QA + E+ + K++++ I+ +QL++ K + E V K+
Sbjct: 1302 KHQAFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE 1350
Query: 1335 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1394
ES Q R + L +Q + + L +E ++ Q + + L V
Sbjct: 1351 VLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDLTSVNI 1404
Query: 1395 ALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQEELQQL 1452
L+KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q + +L
Sbjct: 1405 LLKKQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMEL 1457
Query: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALRARAE 1510
+ E + +R +E+EI V R+ L AT G LQ ++ +
Sbjct: 1458 LEPLNERKHNLLASKEIHQFNR-DVEDEILWVGERMPL-ATSTDHG---HNLQTVQLLIK 1512
Query: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570
+ + +++ Q R + D +R + + +S AEA R++ L+ L L +
Sbjct: 1513 KNQTLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLWGLLI 1565
Query: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
EE E+R R+ E E R Q + A+ AEA + + E E ++E AV
Sbjct: 1566 --EETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDEQSAV 1615
Query: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690
+ L++ + E+ +E + AE V Q ++A
Sbjct: 1616 SMLKK---------------HQILEQAVEDY-------------AETVHQLSKTSRALVA 1647
Query: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAEQELI 1743
E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE+E++
Sbjct: 1648 DSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVV 1707
Query: 1744 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803
E Q + +L+E R+ Q+R + LA E++ + + A
Sbjct: 1708 AGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDA-- 1760
Query: 1804 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1863
+T + K L EL + ++ A + E + A+E R + + + L
Sbjct: 1761 ---ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKHKKLP 1816
Query: 1864 EKLA----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 1919
E+L + R+ T E + +A ++R+L ED A RL+ A KAD
Sbjct: 1817 EELGRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDKAD-- 1867
Query: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979
++K + LE K L+ D RR + F +E + +I
Sbjct: 1868 ----DIQKRENEVLEAWKSLL-DACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI- 1921
Query: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRKAALEE 2037
A++ R EL + + AE + R ++ KSL AR+ A+ E
Sbjct: 1922 -EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHYASEEI 1975
Query: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2097
E+L E+ + + ++ E + L+L E Q A A A+ + Q+ + +
Sbjct: 1976 KEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLSSREIG 2033
Query: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ--SAEEQ 2151
Q +++L EA ++A +E ER E + RRQ EE ER ++ S E
Sbjct: 2034 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2093
Query: 2152 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2185
+ +A++ + + EQ + AEQ + R
Sbjct: 2094 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPR 2127
Score = 103 bits (256), Expect = 5e-21
Identities = 300/1528 (19%), Positives = 616/1528 (40%), Gaps = 172/1528 (11%)
Query: 1050 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1109
+++ + + E+ G + E E ++A E + +R + + + LSA
Sbjct: 664 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 721
Query: 1110 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1168
I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE
Sbjct: 722 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 780
Query: 1169 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1225
+PT D L ++ L Q H E DV R R++ + ER++ V T +R
Sbjct: 781 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 828
Query: 1226 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1284
++ L+ + + E AD W+ + + +Q L D + ++ + ++L E
Sbjct: 829 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 884
Query: 1285 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1344
+ +V + A+Q +++ E ++ + +L S ++ + + + +
Sbjct: 885 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 942
Query: 1345 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1395
++ ++ E S +I E + +E + L A Q++ ER L +EA
Sbjct: 943 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 998
Query: 1396 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1452
L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L
Sbjct: 999 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1055
Query: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
R + + Q A E + Q E + + E + Q +R E
Sbjct: 1056 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1115
Query: 1513 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1566
+ AQ R R Q D E + + L S+ A + R+ ++A L +
Sbjct: 1116 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1175
Query: 1567 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1621
E L E L AE +++ ++ + A +++ R ++ +R
Sbjct: 1176 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1235
Query: 1622 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1669
S+ + H + E R + + ++ ++ + EL W + +EA
Sbjct: 1236 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1294
Query: 1670 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726
L ++ + Q +A+ + K+ K E E K E +AV + +L L K +
Sbjct: 1295 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1350
Query: 1727 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1778
+ E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q
Sbjct: 1351 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1410
Query: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
LE ++ + E+E L + +E +ST E +RL + +F EL E
Sbjct: 1411 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1462
Query: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1889
+R+ L A+++ + R + +++ +GE L T + + +K+ +
Sbjct: 1463 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1517
Query: 1890 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1945
+ ++ + D+ F+R + + + ++ I +RLA L++ L+E+T +
Sbjct: 1518 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1570
Query: 1946 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 2002
+ R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+
Sbjct: 1571 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1625
Query: 2003 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2060
A E+ + ++L A+ +R + + +V++L A +++ R E
Sbjct: 1626 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1685
Query: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2119
R QL +E E+ + Q+ + ++ + R + +
Sbjct: 1686 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1745
Query: 2120 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176
A+E +AA + E R Q AA+ +L K
Sbjct: 1746 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1801
Query: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236
K+ +KHKK E+ R + VE TL+ +H L ++
Sbjct: 1802 ----------KEIFGRIQDKHKKLPEELGRDQNTVE----TLQRMHTTFEHDIQALGTQV 1847
Query: 2237 QRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEA-ENRALILRDKDNTQRFLQ 2294
++L+ +A A Q + ++ ++ + E L K+ ++A E+R + L D + RF
Sbjct: 1848 RQLQEDA--ARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1905
Query: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--TRL 2352
+ M + E+ R + AQE + R ++ +L + +K ++ A ++ T +
Sbjct: 1906 MVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTTCI 1958
Query: 2353 KAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409
+ LL ++ E +E+ +L E +++M + + + + LE + + AEA
Sbjct: 1959 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2018
Query: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQ 2466
L SR ++ ++ ++ K+ E EK T + E++T ++ LE++RQ
Sbjct: 2019 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVRRQ 2077
Query: 2467 QSDHDAER---LREAIAELEREKEKLQQ 2491
Q + + +R E ++ E E QQ
Sbjct: 2078 QEEEERKRRPPSPEPSTKVSEEAESQQQ 2105
Score = 101 bits (251), Expect = 2e-20
Identities = 329/1778 (18%), Positives = 687/1778 (38%), Gaps = 252/1778 (14%)
Query: 1007 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1066
S QR +S+ + L A E T + D E Q + + + E E
Sbjct: 426 SENQRLVSQ-DNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR-ELEAENY-HD 482
Query: 1067 VARLSAEAEKVLALPE---PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI- 1122
+ R++A + V+ L E A R E+ L L K+ Q +++++K + L
Sbjct: 483 IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQD 542
Query: 1123 --RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF-DALRDE 1179
+ G E++L+ H L EA + + AS +K E +P +RD
Sbjct: 543 YGKHLLGVEDLLQKHT--LVEAD-IGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR 599
Query: 1180 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1239
+ + + L Q ER +E R L ++ +A+ + RE E++
Sbjct: 600 VAHMEFCYQELCQLAAERRARLEESRR-----LWKFFWEMAEEEGWIREKEKI------- 647
Query: 1240 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299
S+D G L R L+ +A +++ E+ + GE + + F
Sbjct: 648 -LSSDDYGKDLTSVMRL--------LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG 698
Query: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359
+ I++ + + A LE +++ KK ++ Q D ++
Sbjct: 699 SE---KIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD------DIDAWMLD 749
Query: 1360 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1419
+K +S + +E + Q ++ + +AE A A A Q E+ +
Sbjct: 750 ILKIVSSSDVGHDE---YSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPD 806
Query: 1420 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1479
++ R+ R +E A + +K+++Q+ L + SEA+ + + ++I E
Sbjct: 807 VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 866
Query: 1480 ---EIRVVRLQLEATERQRGGAEGELQALRARAEE-------AEAQKRQAQEEAERLRRQ 1529
++ V++ + E+ E + + + A + +E + + Q++ Q
Sbjct: 867 KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 926
Query: 1530 VQDESQRKRQAEVELASRVKAEAEA------AREKQRALQALEELRLQAEEA---ERRLR 1580
++ RK+ A + S E REK + +++ ++L +R+L
Sbjct: 927 FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 986
Query: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREE 1636
E + ++ L Q+ AE +L+S+ A+ + A++ + EE + RE
Sbjct: 987 GMERDLVA-IEAKLSDLQKEAE-KLESEHPDQAQAILSRLAEIS-DVWEEMKTTLKNREA 1043
Query: 1637 AERRAQQQAEAERAREEAERELERWQLKA---------NEALRLRLQAEEVAQQKSLAQA 1687
+ A + + R ++ + L R Q EA +L Q E + + +
Sbjct: 1044 SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEE 1103
Query: 1688 EAEKQKEEAEREARRRGKAEEQAVRQR---------ELAEQELEKQRQLAEGTAQQRLAA 1738
+ +K ++ E + + A+ +RQR EL + +Q L++ A Q+
Sbjct: 1104 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1163
Query: 1739 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
+ + +AE Q+ L E+ A AA +K+++ + ++ ++ +
Sbjct: 1164 DTK----QAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETG 1219
Query: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
R + S++ ++++++ R R+ E A+ L ++ + ++ ++
Sbjct: 1220 RRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN 1279
Query: 1859 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
E++L + + EA L ++ A + A N+ E E Q L + + +A
Sbjct: 1280 EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ---LISEKPETEA 1336
Query: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
++E+L L K + + L Q + + L E A+L+ L
Sbjct: 1337 VVKEKLTGLHK------------MWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH 1384
Query: 1977 RIRSN--AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2034
+ S ++D + + +Q+ L + E R++E EE L ++ +A Q +
Sbjct: 1385 GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE-----LQSQAQALSQEGKS 1439
Query: 2035 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------------- 2080
+EV+ + V+ E L ++E Q E++
Sbjct: 1440 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1499
Query: 2081 HAFAVQ------QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
H +Q +K Q LQ+ +Q Q +D + E ++ ++ +A R+
Sbjct: 1500 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI---FERSQNIVTDSSSLSAEAIRQRLAD 1556
Query: 2135 RRQ-----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
+Q +EE E+ + EE +A+ AAE +EQE ++ + + +Q+
Sbjct: 1557 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA---KDEQS 1613
Query: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATE 2245
A + ++KH+ EQ + A+ +L+ L H ++ + ++ +L A +
Sbjct: 1614 AVSMLKKHQ-ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1672
Query: 2246 AARQRSQVEEE---LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302
A +R +E LF + ++++L + A E + L LQE + ++
Sbjct: 1673 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE---RFRE 1729
Query: 2303 VAEEAARLSVAAQEAARLRQLAEE----------DLAQQRALAEKMLKEKMQAVQEATRL 2352
A + ++ + + LA+E +A+ + + + ++ + T++
Sbjct: 1730 FARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI 1787
Query: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA------EETQGFQRTLEAERQ------ 2400
A + L + A+E R+Q+ +++ ++L E Q T E + Q
Sbjct: 1788 LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV 1847
Query: 2401 RQLEMSA----------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR---- 2446
RQL+ A +A+ ++ R E+ A + + R + + G+K
Sbjct: 1848 RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV 1907
Query: 2447 -----------TELATQEKVTLVQTLEI-----QRQQSDHDA------------------ 2472
++ QEK V ++E+ Q +++ DA
Sbjct: 1908 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1967
Query: 2473 -----ERLREAIAEL-EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
E ++E + +L E+ KE K + + L+L E Q + + + Q+ +L
Sbjct: 1968 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2027
Query: 2524 S---------EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574
S E + L++R E+ A ++ F + + L + R+QQ+ E+ER+R
Sbjct: 2028 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKR 2085
Query: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2612
S E + + EAE + + +Q+ Q E+
Sbjct: 2086 RPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQ 2123
Score = 100 bits (249), Expect = 3e-20
Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)
Query: 1193 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1252
R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL +
Sbjct: 371 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 427
Query: 1253 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1302
+R Q D AV ++ +A+ +I + E+V+ A++
Sbjct: 428 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 485
Query: 1303 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1360
I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y
Sbjct: 486 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 543
Query: 1361 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
K + + + ++ L E + ER+ V A+ +K E + Q R+
Sbjct: 544 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 602
Query: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1478
+ +E+ + ++R+ EE ++L + AE + R+ E S +
Sbjct: 603 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 655
Query: 1479 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
+ V+RL + A E + G G + E+ A++ +E++R ++ R
Sbjct: 656 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 710
Query: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1596
++ A +E S ++ +++ L + + A++ + + ++ + V +
Sbjct: 711 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 760
Query: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
+ L K AE+ A +L H E+A Q+ AE+ R
Sbjct: 761 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 813
Query: 1657 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1710
ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+
Sbjct: 814 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 872
Query: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1765
V Q E E Q + ++A + +E E QQ +L EL
Sbjct: 873 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 932
Query: 1766 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
+++A +A + + LE K +R + +V+ +++ + + + + K G
Sbjct: 933 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 987
Query: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1881
R+L A+L L +EA E + + + + +LA I + E +
Sbjct: 988 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1036
Query: 1882 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1935
LK +EA E +L++ D + FQ Q A D+ L + K ++
Sbjct: 1037 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1096
Query: 1936 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1982
+ E+ ++ R Q + + + L+ + G EL ++ R N
Sbjct: 1097 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1155
Query: 1983 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2038
+ LR +QAE Q + A E + +L E A ++++ + +
Sbjct: 1156 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1206
Query: 2039 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2094
E++ A VE RRL S R + + + E A ++ K+ ++LQ+
Sbjct: 1207 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1266
Query: 2095 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
LQ Q + +++ + + A ++ + A+ E +++++ +
Sbjct: 1267 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1326
Query: 2151 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199
+ + +A E L + +A R A +A L + AD + H
Sbjct: 1327 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1384
Query: 2200 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256
++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E
Sbjct: 1385 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1442
Query: 2257 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2309
+ S R VQ + + L+ E ++ L ++ R +++E E+M + +
Sbjct: 1443 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1502
Query: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369
Q + Q ++++ + + + + V +++ L AEA
Sbjct: 1503 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1549
Query: 2370 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2425
R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+
Sbjct: 1550 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1609
Query: 2426 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2476
E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L
Sbjct: 1610 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1667
Query: 2477 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
+ +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ
Sbjct: 1668 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1724
Query: 2533 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2572
ERF I QE+ DE +A+ + E ++ R
Sbjct: 1725 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1784
Query: 2573 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2629
+++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L
Sbjct: 1785 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1844
Query: 2630 EQHR 2633
Q R
Sbjct: 1845 TQVR 1848
Score = 100 bits (249), Expect = 3e-20
Identities = 295/1531 (19%), Positives = 569/1531 (37%), Gaps = 279/1531 (18%)
Query: 404 ILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAG 463
I ER +R ++ LE L I K EA L + AD + D +L K+ +
Sbjct: 702 IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDI---DAWMLDILKIVS-SS 757
Query: 464 EVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEY----NLRL 519
+V D S+++ + + + + R + LHE+ A+ E+ ++R
Sbjct: 758 DVGHDEYSTQSLVKKHKDVAEEIANYRPT--------LDTLHEQASALPQEHAESPDVRG 809
Query: 520 K-AGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA-----WVEENQHRVDGAEWGV 573
+ +G+ +VA++T R+ L+D+ Y A W++E + ++ +
Sbjct: 810 RLSGIEERYKEVAELTRL---RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 866
Query: 574 DLPSVEAQLGSHRGLHQSIEEFRAK------IERARSDEGQLSPATRGAYRDCLGRLDLQ 627
L +E L + ++ I R G S A +D L Q
Sbjct: 867 KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 926
Query: 628 YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE-EVGFDWSDRNTNMTAKKESYS 686
+ +L++ K L S S+ ++ + W+ EK + E D + + A + +
Sbjct: 927 FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 986
Query: 687 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 746
+ R+L E K+ +LQ ++L E + S A + W M EA L
Sbjct: 987 GMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLG 1046
Query: 747 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 806
E + QF D+ + + L + Q A+ + D T+T E LL ++ K +++ Y+
Sbjct: 1047 EASKLQQFLRDLDDFQSWLSRTQTAIASE---DMPNTLTEAEKLLTQHENIKNEIDNYEE 1103
Query: 807 HLSGLAKRAKAVVQ---------LKPRHPA--------HPM-RGRLPLLA--------VC 840
+ + V Q L+ R A H M R LL+ +
Sbjct: 1104 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1163
Query: 841 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSV--CFLVPPPNQEA------ 892
D KQ E ++ E L P+ + G+EAA+ N+E
Sbjct: 1164 DTKQAEAFLNN-QEYVLAHTEMPT-----TLEGAEAAIKKQEDFMTTMDANEEKINAVVE 1217
Query: 893 ----------------QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 936
QE V ++ +H+ +L + +K Q +D Q + W
Sbjct: 1218 TGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLW 1277
Query: 937 ---SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQ 993
+ T + + +E R LHS L +QAF+ + L + +E+
Sbjct: 1278 INEKMLTAQDMSYDEARN-LHSKWLKHQAFMAE------------LASNKEW------LD 1318
Query: 994 QLLQSLEQGAQEESRCQRCISE-LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1052
++ + Q E+ + + E L + E E+ T + + D A Q A+
Sbjct: 1319 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1378
Query: 1053 QQK------AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR- 1105
K +Q + + GK + ++ +K L EL+ L Q
Sbjct: 1379 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1438
Query: 1106 ----------SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP----- 1150
++ ++E L+ ++ ++E+ + + + E V +P
Sbjct: 1439 STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATST 1498
Query: 1151 ----ELEATKASLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVE 1202
L+ + +KK L+ + + QP D ++ ER Q + + E
Sbjct: 1499 DHGHNLQTVQLLIKKNQTLQKEIQGHQPRID----------DIFERSQNIVTDSSSLSAE 1548
Query: 1203 RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1262
R+R+A L + W ++ +T+ R R LE+ R +YY ++A+ AW+ + + +
Sbjct: 1549 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA-EAWMSE--QELYMMSE 1605
Query: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1322
D Q+ L++ Q L + +E + E V + + ++ + A E + ++ +
Sbjct: 1606 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALV-ADSHPESERISMRQ---- 1660
Query: 1323 VASPAKKPKVQSGSESVIQEY---VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379
+K K+ +G + + +E +D R +L ++I+E E
Sbjct: 1661 ----SKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAE------REVVAGS 1710
Query: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA-AVDA 1438
+ ++ E + ++ E+ R+ A + +E + + +E++ + A
Sbjct: 1711 HELGQDYEHVTMLQ---ERFREFA----RDTGNIGQERVDTVNHLADELINSGHSDAATI 1763
Query: 1439 QQQKRSIQEELQQLRQSSEAEIQAKARQAEA-------------AERSRLRIEEEIRVVR 1485
+ K + E L + + Q A E + ++ EE+ +
Sbjct: 1764 AEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQ 1823
Query: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEV 1542
+E +R E ++QAL Q RQ QE+A RL+ + +KR+ EV
Sbjct: 1824 NTVETLQRMHTTFEHDIQALGT-------QVRQLQEDAARLQAAYAGDKADDIQKRENEV 1876
Query: 1543 ELASRVKAEAEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1594
A + +A +R +K R + +L L E+ R++ E R L
Sbjct: 1877 LEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELL 1936
Query: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654
+ +AE+ ++ SF + L +H A +++E+ + E+ +E
Sbjct: 1937 MNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT------EKRKEMI 1990
Query: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQA-------------------EAEK---- 1691
++ +RW E LRL L+ + ++ S+A+A E EK
Sbjct: 1991 DKWEDRW-----EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKR 2045
Query: 1692 -----------------------------QKEEAEREARRRGKAEEQAVRQRELAEQELE 1722
++++ E E +RR + E + + E AE + +
Sbjct: 2046 HEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQ 2105
Query: 1723 KQRQLAEGTAQQRLAAEQELIRL--RAETEQ 1751
E +Q L AEQ R+ R++T Q
Sbjct: 2106 WDTSKGEQVSQNGLPAEQGSPRVSYRSQTYQ 2136
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 377 bits (967), Expect = e-103
Identities = 531/2204 (24%), Positives = 909/2204 (41%), Gaps = 278/2204 (12%)
Query: 57 ERAVIR-IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 115
ER+ I+ +ADER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ L
Sbjct: 41 ERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEML 100
Query: 116 PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 174
P+ KG+MR H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI
Sbjct: 101 PKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQ 160
Query: 175 DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232
DI V Q E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LI
Sbjct: 161 DIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLI 220
Query: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
D +K+ NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++
Sbjct: 221 DFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKM 280
Query: 293 PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 344
+ +G R A E + ++Y L LL W+ R+F +S ++
Sbjct: 281 KVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQ 340
Query: 345 WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 401
F ++ +E P K +K + + +++ ++A KV G D+ + W L
Sbjct: 341 LQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLE 400
Query: 402 VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 458
A RE LR+E R E L+++ + +A + E L++ L+ D L A
Sbjct: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
Query: 459 PQRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 517
++ +E D + +R L + Q L K+ H Q + + R + L
Sbjct: 461 KKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNIL 507
Query: 518 RLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVD 574
RL Q LQS ++R E + + QD+L W++E + + AE+G
Sbjct: 508 RL--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKH 559
Query: 575 LPSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQY 628
L VE L H+ + I K++ + EG+ P +D + L+ +
Sbjct: 560 LLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCF 619
Query: 629 AKLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 685
+L N + KA+L + L F + W+ EKE+ D+ T++ + +
Sbjct: 620 EELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH 679
Query: 686 SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 745
A EL + ++++ ++ P +E+ + QW + L + +L
Sbjct: 680 KAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNL 739
Query: 746 KENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 804
++ +FQF D + + LQ L D AT L + +D E+L E
Sbjct: 740 QDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEES 795
Query: 805 KGHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVH 850
+G + L ++A+ + P H ++ L +A D +Q +
Sbjct: 796 RGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFG 855
Query: 851 KGDECQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVC 882
+ D C+L +G + K L + G A S+
Sbjct: 856 ETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLV 915
Query: 883 FLVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW------ 923
P ++E ++ L + QA TL H VD + W
Sbjct: 916 ESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTK 975
Query: 924 -----QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 978
+ L RD+ I +A R L E+ A +++ A R+SQ PE +
Sbjct: 976 VVESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK 1029
Query: 979 LMAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTV 1031
+ G H ++L Q L+Q Q E S+ Q + +L D + L + + V
Sbjct: 1030 ----EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAV 1084
Query: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR 1091
+P E E Q + + + E++G R+ EKV+ + P L
Sbjct: 1085 ASEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLG 1140
Query: 1092 SELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145
LE LG++ + RS + L + + + AE +L E L +
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP 1197
Query: 1146 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205
+ LEA +A ++K E + + RD++ + G +L E ++ ++ +
Sbjct: 1198 DS----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIK 1246
Query: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQA 1262
E+V + +R + + + + +E L R +L+ + ++ L W+ D + +
Sbjct: 1247 EKVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS- 1301
Query: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1320
+++ + + + QA + E+ H +E KQ ++ K LV+ K +
Sbjct: 1302 --YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALH 1358
Query: 1321 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
E A+ +K + S + S + L+TH +++I + + LR + +
Sbjct: 1359 RLWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKD 1410
Query: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRR 1431
L R + + E + + K+ +L E AQ + E +++R + E + R
Sbjct: 1411 LTSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
Query: 1432 EEAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
+ +++ + K I +L ++L + A+ + + + ++ EI
Sbjct: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
Query: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
++E QRG + ++A ++ E + Q +RLR QR R A
Sbjct: 1530 HTPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEA 1586
Query: 1544 LASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALET 1596
+ A EAEA +Q +E+ E A +R LRQ A + R ++
Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR 1646
Query: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
AQ L S E+ +L+ + + + + + EE +R+ + + + E +
Sbjct: 1647 AQ-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD- 1700
Query: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716
+LE+W + E VA + Q + R+ R E A+ Q +
Sbjct: 1701 DLEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERV 1747
Query: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
+R + G ++ AE + E LLE R+Q AA+
Sbjct: 1748 DNVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLH 1800
Query: 1777 RQ--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
R L E + E L AS A + + E+ L + +F+++A
Sbjct: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
Query: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
A E+A+ + +E +A +A + A G T+L A +K
Sbjct: 1861 RLQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFR 1907
Query: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVE 1941
R L R++E Q E L + + ++E+E R K L E
Sbjct: 1908 FFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGE 1967
Query: 1942 DTLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---A 1997
L+++ Q EEI L+ + + E R+R E S++ + EA A
Sbjct: 1968 SLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
Query: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRER 2054
++ LA+ + ++ E++ K A E++ +R AALE+ L+ K R++ ER
Sbjct: 2028 QEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAER 2084
Query: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098
+E+ Q + + A + + + ++E Q LQQ
Sbjct: 2085 PAEETGPQEEEGETAGEAPVSHHAATERTSPGEEEGTWPQNLQQ 2128
Score = 101 bits (251), Expect = 2e-20
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 1178 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1237
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
Query: 1238 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1289
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
Query: 1290 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1347
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
Query: 1348 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1407
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
Query: 1408 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Query: 1466 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1525
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
Query: 1526 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1576
R+V QD + QA L S + ++A EE + + E+
Sbjct: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
Query: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
Query: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
Query: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1751
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
Query: 1752 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1807
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
Query: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
Query: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
Query: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
Query: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2045
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
Query: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
Query: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
Query: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Query: 2226 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2275
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
Query: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2331
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
Query: 2332 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2372
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
Query: 2373 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2426
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
Query: 2427 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2464
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
Query: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2515
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
Query: 2516 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2575
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
Query: 2576 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
Query: 2633 RAALAHS 2639
A++A +
Sbjct: 2017 DASVAEA 2023
Score = 78.2 bits (191), Expect = 2e-13
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1357
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
Query: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1417
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
Query: 1418 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1466
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
Query: 1467 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1522
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
Query: 1523 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1562
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
Query: 1563 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1605
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Query: 1606 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1647
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Query: 1648 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
Query: 1699 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1743
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
Query: 1744 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
Query: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
E S + KQ + R++ + R + A R + E
Sbjct: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
Query: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1916
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
Query: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
Query: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
Query: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2084
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
Query: 2085 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2135
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
Query: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
Query: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2255
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
Query: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2315
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
Query: 2316 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2369
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
Query: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2427
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
Query: 2428 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2473
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
Query: 2474 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2528
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
Query: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
Query: 2589 AEEGVRRKQEELQQLEQQRRQQEEL 2613
E +RK E + L Q +R+ ++L
Sbjct: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
Score = 77.8 bits (190), Expect = 2e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
Query: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1815
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
Query: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
Query: 1876 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1930
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
Query: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1982
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
Query: 1983 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2039
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
Query: 2040 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2093
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
Query: 2094 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
Query: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2209
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
Query: 2210 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2260
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
Query: 2261 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
Query: 2318 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
Query: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
Query: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2487
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
Query: 2488 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2541
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
Query: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2597
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
Query: 2598 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2643
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
Score = 75.1 bits (183), Expect = 1e-12
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2027
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
Query: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2083
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
Query: 2084 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
Query: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2193
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
Query: 2194 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2235
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
Query: 2236 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
Query: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
Query: 2352 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
Query: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
Query: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2520
++ E E+++ ++ L + Q E + L +
Sbjct: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
Query: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
Query: 2581 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2638
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
Query: 2639 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2698
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
Query: 2699 LAQGHTTVDEL 2709
+ QG T + L
Sbjct: 1127 VIQGQTDPEYL 1137
Score = 74.3 bits (181), Expect = 3e-12
Identities = 302/1499 (20%), Positives = 557/1499 (37%), Gaps = 179/1499 (11%)
Query: 1059 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1118
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
Query: 1119 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1178
+ QG + L+A + + + AT+A KK + E +
Sbjct: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
Query: 1179 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1238
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
Query: 1239 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1298
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
Query: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1355
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Query: 1356 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
Query: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1457
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
Query: 1458 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1505
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
Query: 1506 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1560
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
Query: 1561 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1613
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
Query: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1670
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
Query: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
Query: 1731 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1786
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
Query: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1841
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
Query: 1842 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1894
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
Query: 1895 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
Query: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
Query: 2013 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2072
R Q L+A Q +V++ A +++ R+R + QL +E
Sbjct: 1643 LASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL 1702
Query: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-EAARRAAEEAEEARVQAER-- 2129
EK + E+ Q + D+ R A E E + ER
Sbjct: 1703 EQWISEK----ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLI 1758
Query: 2130 -----EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQA 2182
EAA + + E R Q AA+ L + E +
Sbjct: 1759 DAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHR 1818
Query: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242
L + DA AE R E+EL L +Q+++ L KAE
Sbjct: 1819 ELPEDVGLDAST------AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAE 1872
Query: 2243 ATE----------------AARQRSQVEE-----ELFSV-RVQMEELSKLKARIEAENRA 2280
A + A +R+Q+ + FS+ R + + + +IE + R
Sbjct: 1873 AIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERP 1932
Query: 2281 LILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEK 2337
+ + ++ Q AE + +A L + R Q +EE + QQ K
Sbjct: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRK 1992
Query: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+ EK +A E RL+ E+ Q ++ + +A + ++ + ++ ++
Sbjct: 1993 EMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKR 2050
Query: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2456
+ ++ AER A + + ++ Q + AEE G + E A + V+
Sbjct: 2051 HEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVS 2105
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 375 bits (964), Expect = e-103
Identities = 534/2210 (24%), Positives = 912/2210 (41%), Gaps = 281/2210 (12%)
Query: 57 ERAVIR-IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 115
ER+ I+ +ADER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ L
Sbjct: 41 ERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEML 100
Query: 116 PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 174
P+ KG+MR H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI
Sbjct: 101 PKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQ 160
Query: 175 DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232
DI V Q E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LI
Sbjct: 161 DIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLI 220
Query: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
D +K+ NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++
Sbjct: 221 DFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKM 280
Query: 293 PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 344
+ +G R A E + ++Y L LL W+ R+F +S ++
Sbjct: 281 KVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQ 340
Query: 345 WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 401
F ++ +E P K +K + + +++ ++A KV G D+ + W L
Sbjct: 341 LQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLE 400
Query: 402 VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 458
A RE LR+E R E L+++ + +A + E L++ L+ D L A
Sbjct: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
Query: 459 PQRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 517
++ +E D + +R L + Q L K+ H Q + + R + L
Sbjct: 461 KKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNIL 507
Query: 518 RLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVD 574
RL Q LQS ++R E + + QD+L W++E + + AE+G
Sbjct: 508 RL--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKH 559
Query: 575 LPSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQY 628
L VE L H+ + I K++ + EG+ P +D + L+ +
Sbjct: 560 LLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCF 619
Query: 629 AKLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 685
+L N + KA+L + L F + W+ EKE+ D+ T++ + +
Sbjct: 620 EELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH 679
Query: 686 SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 745
A EL + ++++ ++ P +E+ + QW + L + +L
Sbjct: 680 KAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNL 739
Query: 746 KENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 804
++ +FQF D + + LQ L D AT L + +D E+L E
Sbjct: 740 QDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEES 795
Query: 805 KGHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVH 850
+G + L ++A+ + P H ++ L +A D +Q +
Sbjct: 796 RGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFG 855
Query: 851 KGDECQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVC 882
+ D C+L +G + K L + G A S+
Sbjct: 856 ETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLV 915
Query: 883 FLVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW------ 923
P ++E ++ L + QA TL H VD + W
Sbjct: 916 ESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTK 975
Query: 924 -----QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 978
+ L RD+ I +A R L E+ A +++ A R+SQ PE +
Sbjct: 976 VVESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK 1029
Query: 979 LMAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTV 1031
+ G H ++L Q L+Q Q E S+ Q + +L D + L + + V
Sbjct: 1030 ----EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAV 1084
Query: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR 1091
+P E E Q + + + E++G R+ EKV+ + P L
Sbjct: 1085 ASEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLG 1140
Query: 1092 SELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145
LE LG++ + RS + L + + + AE +L E L +
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP 1197
Query: 1146 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205
+ LEA +A ++K E + + RD++ + G +L E ++ ++ +
Sbjct: 1198 DS----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIK 1246
Query: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQA 1262
E+V + +R + + + + +E L R +L+ + ++ L W+ D + +
Sbjct: 1247 EKVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS- 1301
Query: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1320
+++ + + + QA + E+ H +E KQ ++ K LV+ K +
Sbjct: 1302 --YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALH 1358
Query: 1321 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
E A+ +K + S + S + L+TH +++I + + LR + +
Sbjct: 1359 RLWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKD 1410
Query: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRR 1431
L R + + E + + K+ +L E AQ + E +++R + E + R
Sbjct: 1411 LTSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
Query: 1432 EEAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
+ +++ + K I +L ++L + A+ + + + ++ EI
Sbjct: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
Query: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
++E QRG + ++A ++ E + Q +RLR QR R A
Sbjct: 1530 HTPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEA 1586
Query: 1544 LASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALET 1596
+ A EAEA +Q +E+ E A +R LRQ A + R ++
Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR 1646
Query: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
AQ L S E+ +L+ + + + + + EE +R+ + + + E +
Sbjct: 1647 AQ-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD- 1700
Query: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716
+LE+W + E VA + Q + R+ R E A+ Q +
Sbjct: 1701 DLEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERV 1747
Query: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
+R + G ++ AE + E LLE R+Q AA+
Sbjct: 1748 DNVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLH 1800
Query: 1777 RQ--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
R L E + E L AS A + + E+ L + +F+++A
Sbjct: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
Query: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
A E+A+ + +E +A +A + A G T+L A +K
Sbjct: 1861 RLQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFR 1907
Query: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVE 1941
R L R++E Q E L + + ++E+E R K L E
Sbjct: 1908 FFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGE 1967
Query: 1942 DTLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---A 1997
L+++ Q EEI L+ + + E R+R E S++ + EA A
Sbjct: 1968 SLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
Query: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRER 2054
++ LA+ + ++ E++ K A E++ +R AALE+ L+ K R++ ER
Sbjct: 2028 QEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAER 2084
Query: 2055 AEQESARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
+E+ Q + A EA A E+ ++ + ++LQ E S
Sbjct: 2085 PAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
Score = 101 bits (251), Expect = 2e-20
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 1178 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1237
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
Query: 1238 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1289
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
Query: 1290 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1347
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
Query: 1348 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1407
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
Query: 1408 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Query: 1466 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1525
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
Query: 1526 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1576
R+V QD + QA L S + ++A EE + + E+
Sbjct: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
Query: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
Query: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
Query: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1751
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
Query: 1752 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1807
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
Query: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
Query: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
Query: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
Query: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2045
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
Query: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
Query: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
Query: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Query: 2226 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2275
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
Query: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2331
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
Query: 2332 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2372
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
Query: 2373 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2426
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
Query: 2427 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2464
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
Query: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2515
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
Query: 2516 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2575
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
Query: 2576 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
Query: 2633 RAALAHS 2639
A++A +
Sbjct: 2017 DASVAEA 2023
Score = 78.2 bits (191), Expect = 2e-13
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1357
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
Query: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1417
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
Query: 1418 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1466
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
Query: 1467 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1522
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
Query: 1523 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1562
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
Query: 1563 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1605
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Query: 1606 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1647
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Query: 1648 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
Query: 1699 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1743
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
Query: 1744 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
Query: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
E S + KQ + R++ + R + A R + E
Sbjct: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
Query: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1916
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
Query: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
Query: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
Query: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2084
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
Query: 2085 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2135
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
Query: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
Query: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2255
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
Query: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2315
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
Query: 2316 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2369
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
Query: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2427
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
Query: 2428 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2473
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
Query: 2474 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2528
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
Query: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
Query: 2589 AEEGVRRKQEELQQLEQQRRQQEEL 2613
E +RK E + L Q +R+ ++L
Sbjct: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
Score = 77.8 bits (190), Expect = 2e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
Query: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1815
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
Query: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
Query: 1876 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1930
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
Query: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1982
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
Query: 1983 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2039
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
Query: 2040 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2093
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
Query: 2094 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
Query: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2209
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
Query: 2210 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2260
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
Query: 2261 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
Query: 2318 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
Query: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
Query: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2487
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
Query: 2488 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2541
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
Query: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2597
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
Query: 2598 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2643
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
Score = 75.1 bits (183), Expect = 1e-12
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2027
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
Query: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2083
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
Query: 2084 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
Query: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2193
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
Query: 2194 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2235
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
Query: 2236 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
Query: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
Query: 2352 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
Query: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
Query: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2520
++ E E+++ ++ L + Q E + L +
Sbjct: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
Query: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
Query: 2581 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2638
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
Query: 2639 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2698
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
Query: 2699 LAQGHTTVDEL 2709
+ QG T + L
Sbjct: 1127 VIQGQTDPEYL 1137
Score = 74.3 bits (181), Expect = 3e-12
Identities = 302/1499 (20%), Positives = 557/1499 (37%), Gaps = 179/1499 (11%)
Query: 1059 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1118
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
Query: 1119 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1178
+ QG + L+A + + + AT+A KK + E +
Sbjct: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
Query: 1179 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1238
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
Query: 1239 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1298
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
Query: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1355
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Query: 1356 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
Query: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1457
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
Query: 1458 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1505
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
Query: 1506 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1560
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
Query: 1561 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1613
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
Query: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1670
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
Query: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
Query: 1731 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1786
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
Query: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1841
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
Query: 1842 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1894
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
Query: 1895 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
Query: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
Query: 2013 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2072
R Q L+A Q +V++ A +++ R+R + QL +E
Sbjct: 1643 LASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL 1702
Query: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-EAARRAAEEAEEARVQAER-- 2129
EK + E+ Q + D+ R A E E + ER
Sbjct: 1703 EQWISEK----ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLI 1758
Query: 2130 -----EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQA 2182
EAA + + E R Q AA+ L + E +
Sbjct: 1759 DAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHR 1818
Query: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242
L + DA AE R E+EL L +Q+++ L KAE
Sbjct: 1819 ELPEDVGLDAST------AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAE 1872
Query: 2243 ATE----------------AARQRSQVEE-----ELFSV-RVQMEELSKLKARIEAENRA 2280
A + A +R+Q+ + FS+ R + + + +IE + R
Sbjct: 1873 AIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERP 1932
Query: 2281 LILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEK 2337
+ + ++ Q AE + +A L + R Q +EE + QQ K
Sbjct: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRK 1992
Query: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
+ EK +A E RL+ E+ Q ++ + +A + ++ + ++ ++
Sbjct: 1993 EMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKR 2050
Query: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2456
+ ++ AER A + + ++ Q + AEE G + E A + V+
Sbjct: 2051 HEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVS 2105
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 357 bits (917), Expect = 1e-97
Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%)
Query: 69 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 125
++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H
Sbjct: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
Query: 126 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 185
L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + +
Sbjct: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
Query: 186 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 240
+A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D +
Sbjct: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
Query: 241 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 300
L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R
Sbjct: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257
Query: 301 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 352
E +L +Y +LV LL+W+ E R FP S + L + F F+
Sbjct: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317
Query: 353 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 408
E P + + ++ + L+ A+QA Q + P G ++ + W L A R
Sbjct: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
Query: 409 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 464
+ L+ +L+ L+ + + Q +A L E L A+ +L L QR G
Sbjct: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
Query: 465 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 524
+E + + + L L+ ++ + RR + V +R + RL +
Sbjct: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488
Query: 525 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 583
QVA + + S+ + E L LQ+ Q + E +EAQ+
Sbjct: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548
Query: 584 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 643
+H + + A+++ + ++ A L +L L+ + +A L
Sbjct: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604
Query: 644 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 703
F+ +E WL E + + + + + AL E+ + +L
Sbjct: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664
Query: 704 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 763
G L P +P A+Q W + A L+ Q+F+D EA
Sbjct: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724
Query: 764 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 815
L++ + +L R SC D++A T RLE +L+ E +L E S A
Sbjct: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783
Query: 816 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 875
L P P +R P + + GD ++ PA+P
Sbjct: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824
Query: 876 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 935
P P + Q+ +++ +AL L + +L + S ++QL
Sbjct: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878
Query: 936 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 992
+ ++P Q L ++L Y+ FL G E AE + Y S
Sbjct: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936
Query: 993 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1027
Q+ + L Q G E + ++ + +L+D+ LQLEA +
Sbjct: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996
Query: 1028 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1086
T H L+L K E +R+ Q +VE EP A
Sbjct: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034
Query: 1087 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1146
+ L+ ++E G L+QV+ E+V + Q E QA
Sbjct: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070
Query: 1147 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1206
+ L E + + ++AQ +++ + D +RL + H + E+ W+E
Sbjct: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121
Query: 1207 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1262
R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ +
Sbjct: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180
Query: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1322
+ QA L ++ GE V E +Q+ +++ L T + E
Sbjct: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231
Query: 1323 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379
+ + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE
Sbjct: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290
Query: 1380 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1434
Q EE+ +A E A Q + H A+++ A R E Q++ E++ R
Sbjct: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350
Query: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494
+ IQ LQ LR EA + + + +++ Q E RQ
Sbjct: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392
Query: 1495 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1550
A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A
Sbjct: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452
Query: 1551 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1609
E Q+ L+ LE LQ A R L+ QA VE + ++ AE
Sbjct: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510
Query: 1610 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1658
S+ E L R +E V V + + +R A +A+ E+ +
Sbjct: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
Query: 1659 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716
W +A EA LQ QQ L +E E EE R ++A R +
Sbjct: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
Query: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
+ + ++ ++ + L + + EQ ++ L E+L LQ AA +
Sbjct: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687
Query: 1777 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1826
+ELE E + +++ LAS+ +A + S E + L + +F+ E+
Sbjct: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747
Query: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1882
+ L E+ +R + RQR + A L E A G A R TE +
Sbjct: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806
Query: 1883 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 1931
+ E E+ L + A LE Q H+ E +L +L + +
Sbjct: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866
Query: 1932 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 1987
+ G ++QR+Q + A+ + + E L R R+ D R
Sbjct: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926
Query: 1988 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
++ ++E + Q + L AE E R + ++ Q A A K
Sbjct: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986
Query: 2036 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2089
EE+ L+ + ++ R +ER + E QL L + + + A E A+
Sbjct: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
Query: 2090 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2135
+E++Q +++ + L L + + A R + RV+ +E A+SR
Sbjct: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106
Query: 2136 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2194
A L S + A QA QA A++L++ R + L + QA +AE+
Sbjct: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163
Query: 2195 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2232
+ H+ K E L Q +V Q L LR L+ +E + ++N L
Sbjct: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223
Query: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2283
E LQR+ + EA Q +V+ + + +E +L+ R+ + A I
Sbjct: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
Query: 2284 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2319
D + + + E++K Q E A + V ++E
Sbjct: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340
Query: 2320 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2367
+ + +E A +AL +++L++ + +E ++A+ E L+++ + +
Sbjct: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400
Query: 2368 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2418
E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+
Sbjct: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457
Query: 2419 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2476
M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R
Sbjct: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513
Query: 2477 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2535
+ +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+
Sbjct: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556
Query: 2536 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2594
+ +E + + D +A + L + + + +E + + ++++E R H+ G
Sbjct: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613
Query: 2595 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2654
Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + +
Sbjct: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670
Query: 2655 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2709
LD A+ L+++ + Q +A + +ELQR Q GH + +
Sbjct: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723
Query: 2710 ARR 2712
R
Sbjct: 2724 QER 2726
Score = 179 bits (454), Expect = 6e-44
Identities = 467/2118 (22%), Positives = 814/2118 (38%), Gaps = 368/2118 (17%)
Query: 452 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 511
L A + ++ E++ ++ ++ + + ++L HPQ + + + L +
Sbjct: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576
Query: 512 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 571
R AQ Q+V + D + +L WVEE + V ++
Sbjct: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619
Query: 572 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 630
G D + + H+ L + + + + +E L+ P R RL Q
Sbjct: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
Query: 631 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 686
L + R R LE LH F+ A WL ++K+ + G + + ++
Sbjct: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
Query: 687 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 746
++E+ +++ + + LL H A P V Q LQT WS + +L
Sbjct: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791
Query: 747 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 806
+A G ALR D T+ DLL+ +E+
Sbjct: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825
Query: 807 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 866
P + A + G + ++ H+G E +LVG +
Sbjct: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858
Query: 867 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 926
++L ++G V +C P +A R +A QA L ++ L + L
Sbjct: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910
Query: 927 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 981
R +R SW+ + L+ EE Q S L+L +LR +A
Sbjct: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960
Query: 982 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1041
E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++
Sbjct: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017
Query: 1042 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1082
REC + I Q+ + LG V L+A+ +K AL E
Sbjct: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077
Query: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1139
+ P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL
Sbjct: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137
Query: 1140 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1199
KE P L + K LK +AE Q A + + + GE L + R
Sbjct: 2138 KEP-VPPGDLRD--KLKPLLKHQAFEAEVQ-----AHEEVMTSVAKKGEALLAQSHPRAG 2189
Query: 1200 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA------ 1253
EV +R+ L + W+ + +R +ELE R + + D AW+Q+
Sbjct: 2190 EVS---QRLQGLRKHWEDLRQAMALRGQELEDR-RNFLEFLQRVDLAEAWIQEKEVKMNV 2245
Query: 1254 -------------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE-CQRFA 1299
RRR + + D+ L+ R E+V+ CQR
Sbjct: 2246 GDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQR-R 2304
Query: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359
Q N + L+ Y+ QLE + IQE L +
Sbjct: 2305 SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD-----CGK 2359
Query: 1360 YIKFISETLRRMEEEER----LAEQQRAEERE--RLAE--VEAA---LEKQRQLAEAHAQ 1408
++ + LR+ EE ER + Q + ERE RL + EAA +Q+++AE+ Q
Sbjct: 2360 DLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ 2419
Query: 1409 AKAQAER---------EAKELQQRMQEEVV--RREEAAVDAQQQKRSIQEELQQLRQSSE 1457
+++A++ +A++LQ +QE +V +R A +D RS E + L + E
Sbjct: 2420 LRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQE 2479
Query: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517
+ + + ++ +R ++ + + G E EL +L +E + Q +
Sbjct: 2480 CKAELDS-WTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQ 2538
Query: 1518 QAQE------EAERLRRQVQDESQ-------------------RKRQAEVEL---ASRVK 1549
QA E E++ R + + + + E +L A ++
Sbjct: 2539 QALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKIS 2598
Query: 1550 AEAEAAR--------EKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETAQR 1599
A AR E Q AL + + L+ E R+ R+ +E RQ+Q L+ +Q
Sbjct: 2599 ALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQE 2658
Query: 1600 SAEAELQSKRASFAEK----TAQLERSLQEEHVAVAQLREEAERRAQQQAEAER------ 1649
A A L+ K E+ TA L LQ++ A+L ++ + Q E +R
Sbjct: 2659 VA-AWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
Query: 1650 -AREEAERELER----WQ-------------LKANEALRLRLQAEEVAQQKSLAQAE--- 1688
A E + LE W KA EALRLR EE+ + E
Sbjct: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777
Query: 1689 ---------------AEKQKEEAEREARRRGKA---EEQA-VRQRELAEQELEKQ----- 1724
+++ E A + R+ +A + QA VR+ Q++E+Q
Sbjct: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLL 2837
Query: 1725 ---RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-ELARLQREAAAAT------ 1774
+ L E ++R A E + L+ + E+ + E+ LA Q + +
Sbjct: 2838 QRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQ 2897
Query: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
++ Q LE+E++ A V+L + + + + + R++ L EAAR R
Sbjct: 2898 EQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRR 2957
Query: 1835 ALAEEAKRQRQLAEE--DAARQRAEAERVL-AEKLAAIGEATR-LKTEAEIALKEKEAEN 1890
L ++A+ +Q E +A AE VL +E + EAT+ L E ++ EA +
Sbjct: 2958 LLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
Query: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIE---ERLAQLRKASDSELERQKGLVEDTLRQR 1947
R+ RL + A R ++ + A ++ E A+L + +++ R GL E Q
Sbjct: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEA---RGHGLQEQL--QL 3072
Query: 1948 RQVEEEILALKASFE-KAAAGKAE---LELELGRIRSNAEDTLRSKEQA--ELEAARQRQ 2001
Q+E E L L A KAA +++ +LE ++ D R + Q+ + + R+
Sbjct: 3073 HQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRK 3132
Query: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQR-KAALEEVER-LKAKVEEARRLRE-RAEQE 2058
LA ER +Q A R R +AA E +++ +KA+ E E + Q+
Sbjct: 3133 LAGTLERGAPRRYPHIQ--------AQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
Query: 2059 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
+A +LQ + ++ E+ H+ + + Q+ + L++E + E E AR E
Sbjct: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAM-----EKEVARLQTE 3239
Query: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
++ ++ Q E L+ A+E+ Q AQA L + E A
Sbjct: 3240 ACRLGQLHPAAPGGLAKVQ-EAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLA----- 3293
Query: 2179 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2238
A RQ+ A+ E+ + AEQ L Q ++ QE+ RLQ ++ + L +
Sbjct: 3294 --WAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351
Query: 2239 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2298
+ AE TE +EL ++EE L+ + AE+ L +
Sbjct: 3352 MSAEVTECL-------QELEGRLQELEEAWALRWQRCAESWGL----------------Q 3388
Query: 2299 KMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRAL-AEKMLKEKMQAVQEATRL 2352
K++Q E+A +A E L+ +++ +L R EK+L + + + +
Sbjct: 3389 KLRQRLEQAEAW-LACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT 3447
Query: 2353 KAEAELLQQQKELAQEQA 2370
+ E ELL Q +EL +A
Sbjct: 3448 EMEQELLLQPQELKPGRA 3465
Score = 168 bits (426), Expect = 1e-40
Identities = 525/2412 (21%), Positives = 903/2412 (37%), Gaps = 375/2412 (15%)
Query: 529 QVAQVTLQSVQRRPELE--DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 586
QV + Q +R+ E + S L+ Q LL W E Q ++ E VD+ S + L H+
Sbjct: 1051 QVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110
Query: 587 GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA-KLLNSSKARLRSL--- 642
L +EE ER + + Q P A DC ++ ++L L+ L
Sbjct: 1111 DL---LEEIHLWQERLQQLDAQSQPM---AALDCPDSQEVPNTLRVLGQQGQELKVLWEQ 1164
Query: 643 ---------------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA 687
+ F A WL+ + +G D + + + +E
Sbjct: 1165 RQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVREALSLLQQHRE---- 1217
Query: 688 LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE 747
R L + + L+ G++L++ HPA TV ++Q QW+ +L E ++
Sbjct: 1218 FGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWT---RLQGRSEQRRRQ 1274
Query: 748 NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH 807
A Q + ++ +L + E + + S + L+ + + +L + H
Sbjct: 1275 LLASLQL-QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRH 1333
Query: 808 LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 867
+ L + + ++ +P L + + ++T +GDE Q G Q +
Sbjct: 1334 VEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT-ERGDELQQAGQ-QEQLLR 1391
Query: 868 VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 927
L + + Q+ + + RL+ +HQ L + L M +L +
Sbjct: 1392 QLQDAKEQLEQLEGALQSSETGQDLRSS-QRLQKRHQQLESESRTLAAKMAALASMAHGM 1450
Query: 928 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 987
I + R L+ + A+ L+L QA + Q E +AE
Sbjct: 1451 AASPAILEETQKHLRRLELLQGHLAIRGLQL--QASVELHQFCHLSNMELSWVAEHMPHG 1508
Query: 988 CSHHYQQLL---QSLEQGAQE--------ESRCQRCISELKDIRLQ--------LEACET 1028
Y + L QSL + +E + + QR +S + + +E C+
Sbjct: 1509 SPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQE 1568
Query: 1029 RTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1088
H L E +C Q+ Q+ +V L V + V + A
Sbjct: 1569 LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEE---KRPLVSSRDYGRDEAA 1625
Query: 1089 TLRSELELTLGKLEQVRSLSAIY---LEKLKTISLVIRGTQGAEEVLRAHE---EQLKEA 1142
TLR + K + ++ AIY +E+L + + G + E+ E EQL+
Sbjct: 1626 TLR-----LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL 1680
Query: 1143 QAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE------RLQQRHG 1195
Q + AT ELE T + LR +AE Q + + +G + +GE L +
Sbjct: 1681 QELAATRDRELEGTLRLHEFLR-EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739
Query: 1196 ERDVEVERWRERVA-------QLLER------------------WQAVLAQTDVRQRELE 1230
+ +VE +RVA LLER W + T R L
Sbjct: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR 1799
Query: 1231 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP---LADSQAVREQLRQEQALLEEIER 1287
LR +R+ + L + QE+ ++P D + QLR Q L E+
Sbjct: 1800 DTETTLRVHRDLLEVL-------TQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVG 1852
Query: 1288 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQ------------LEPVASPAKKPKVQSG 1335
+++E A + + V + Q +E + ++ ++ +
Sbjct: 1853 TERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR 1912
Query: 1336 SESVIQEYV--------DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1387
+ +++Y DL+ S +S +K + R E E R Q+A +
Sbjct: 1913 FRTAVRDYASWAARVRQDLQVEESSQEP-SSGPLKLSAHQWLRAELEAREKLWQQATQLG 1971
Query: 1388 RLAEVEAAL------EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE----EAAVD 1437
+ A + A E+ R L + Q R+ + LQ QE++ RE E +
Sbjct: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031
Query: 1438 AQQQKR------SIQEELQQLRQSSEAEIQAKARQ--AEAAERSRLRIEEEIRV---VRL 1486
AQ+ S EE++QL + E ++ Q EAA R RL+ RV + +
Sbjct: 2032 AQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPI 2091
Query: 1487 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE------AERLRRQVQDESQRKRQA 1540
L+ R + AE AL A A + Q E A++L+ V R +
Sbjct: 2092 LLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLK 2151
Query: 1541 EVELASRVKAEAEAAREKQRALQALEELRL-----QAEEAERRLR--QAEVERARQVQVA 1593
+ +AE +A E ++ E L +A E +RL+ + E RQ
Sbjct: 2152 PLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAM-- 2209
Query: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA--VAQLREEAERRAQQQAEAERAR 1651
A R E E + F ++ E +QE+ V V L ++ E Q + R
Sbjct: 2210 ---ALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFR 2266
Query: 1652 -EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE------REARRRG 1704
A + +++ L L+L+ + + K + Q ++ A R ++
Sbjct: 2267 GNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLE 2326
Query: 1705 KAEEQAVRQREL---AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQRQ 1757
A E V REL ++ EK+ + + L + Q L+R E E+ + Q +
Sbjct: 2327 GALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVE 2386
Query: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1817
LE E+ RL + + A + + E+A E L S+A+ E+ ++ Q+L+
Sbjct: 2387 SLEREVGRLCQRSPEAAHGLRHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQ 2441
Query: 1818 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1877
A +EL A RLRA + + R E A R E + AE + + ++
Sbjct: 2442 A---MLQELLVSAQRLRAQMDTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARS 2496
Query: 1878 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQ 1936
+ L + +R++ + LE +H+ +++ L QL +S ++ER
Sbjct: 2497 TGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERW 2556
Query: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996
ED+L + + + ++ K + +LE++ G+I S E T R Q
Sbjct: 2557 LCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPE 2614
Query: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2056
A+ + R+EA R + E RQ +A L++ + + A + E + L E
Sbjct: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEE 2673
Query: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116
+ AQ Q+ QAE A Q+ ++E Q+ LQ + ++ E
Sbjct: 2674 GLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGAL 2733
Query: 2117 AEEAEE------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRK 2167
E ++ A++Q EA + RR +EE E + E + +A QA E L
Sbjct: 2734 WGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGT 2793
Query: 2168 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD- 2226
+ E EAA +A QA QA E H A+ Q ++ Q +LR L+E
Sbjct: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRT 2852
Query: 2227 --HQKNLL-------DEELQRLKAEATEAA---------------RQRSQVEEELFS--- 2259
++LL DEE+ ++ + AA Q +E E+ S
Sbjct: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEA 2912
Query: 2260 ------------------------VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2295
RVQ E + R EA R L+L+ Q+FL E
Sbjct: 2913 LTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTE 2972
Query: 2296 EAEKMKQVAEEAARLS------VAAQEAARLRQLAE------------EDLAQQRALAEK 2337
E +AE L A A LR+L E L Q AL E
Sbjct: 2973 LLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLES 3032
Query: 2338 -------MLKEKMQAVQEA-----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2385
+ ++QAV+EA R +A LQ+Q +L Q + L D +
Sbjct: 3033 RKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAAT 3092
Query: 2386 EETQGFQRTLEAER---------QRQLEMSAEAERLKLR-----------------VAEM 2419
E+Q + + LE + +++++ +A+ LR A+
Sbjct: 3093 AESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQR 3152
Query: 2420 SRAQARAEEDAQRFRKQAEEI--GEKLHRTELAT-------QEKVTL------------V 2458
SR +A E Q + + E + ++H + A QEK L V
Sbjct: 3153 SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSV 3212
Query: 2459 QTLEIQRQQSDHDAERLREAIAELEREK--------------EKLQQEAKLLQLKSEE-- 2502
+TL+ Q ++ + + E + + +A L+ E K+Q+ LQ K++E
Sbjct: 3213 RTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERG 3272
Query: 2503 ---MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559
Q Q L Q L ++ E+ L E E + A EQL Q++R
Sbjct: 3273 QWLAQAAQGHAFLGRCQEL-LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR- 3329
Query: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2617
E + Q Q + QE Q+LV + + E E ++ + LQ+LE+ + + AE
Sbjct: 3330 ECRLQAQDLRQEGQQLV---DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWG 3386
Query: 2618 NQRLREQLQLLE 2629
Q+LR++L+ E
Sbjct: 3387 LQKLRQRLEQAE 3398
Score = 139 bits (351), Expect = 5e-32
Identities = 451/2066 (21%), Positives = 800/2066 (38%), Gaps = 334/2066 (16%)
Query: 922 AWQSLRRDVQLIRS-WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 980
A ++R +Q I++ W+ R+ + +RQ L SL+L Q + +D + + E LM
Sbjct: 1246 AAHTVREQLQSIQAQWTRLQGRS--EQRRRQLLASLQL--QEWKQDVAELMQWMEEKGLM 1301
Query: 981 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL---EACETRTVH-RLRL 1036
A E + Q L+ E E +R + L+ + +L C + RL+
Sbjct: 1302 AAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQG 1361
Query: 1037 PLDKEPA--RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1094
K A R+ +R E Q+A + E L + + + E++ + S LRS
Sbjct: 1362 LRSKWEALNRKMTERGDELQQA-GQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
Query: 1095 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1154
L + +Q+ S S K+ ++ + G + +L ++ L+ + + L
Sbjct: 1421 RLQK-RHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHL----- 1474
Query: 1155 TKASLKKLRAQAEAQQPTFDALRDE--------------------LRGAQEVGERLQQRH 1194
+++ L+ QA + F L + L GAQ L ++H
Sbjct: 1475 ---AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQS----LHRKH 1527
Query: 1195 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1254
E VEV+ + +V ++L +++ A + + + + ++L G W + R
Sbjct: 1528 KELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE---------GHWAELER 1578
Query: 1255 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK------------QY 1302
+ A +Q +++ + +Q L+ E G VEE + +
Sbjct: 1579 ACE--------ARAQCLQQAVTFQQYFLDVSELEGW-VEEKRPLVSSRDYGRDEAATLRL 1629
Query: 1303 INAIKDYELQLVTYKAQLEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359
IN + + +L Y + +E + A+ P+V + V+QE LR L L +
Sbjct: 1630 INKHQALQEELAIYWSSMEELDQTAQTLTGPEVPE-QQRVVQER--LREQLRALQELAAT 1686
Query: 1360 YIKFISETLRRME---EEERL-----AEQQRAEERERLAE-VEAALEKQRQLAEAHAQAK 1410
+ + TLR E E E L +++Q A+ E L E E AL + A+ Q +
Sbjct: 1687 RDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746
Query: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1470
++R A + + E ++ R +A +Q+ Q++LQ QA+
Sbjct: 1747 MGSQRVAA--CRLLAESLLERGHSAGPMVRQR---QQDLQTAWSELWELTQARGHALRDT 1801
Query: 1471 ERSRLRIEEEIRVVRLQLEA--------TERQRGGAEGELQALRARAEEAEAQKRQAQEE 1522
E + LR+ ++ V Q++ R G E +L++ + E +RQ QE
Sbjct: 1802 ETT-LRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860
Query: 1523 AERLRR-----------QVQDESQRKRQAEVELASRV---KAEAEAAREKQRALQALEEL 1568
E R VQ Q QA L R+ +A+ E AR R A+ +
Sbjct: 1861 LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920
Query: 1569 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL----- 1623
A + L+ E + +A + AEL+++ + + T +++L
Sbjct: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980
Query: 1624 -----QEEHVAVAQLREEAER---RAQQQAEAERAREEAERELERWQ-LKANEALRLRLQ 1674
QEE A+ R++ + R Q++ +AE+ + RE R + + A + + L+
Sbjct: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040
Query: 1675 A-----EEVAQ-----QKSLAQAEAEKQKEEAEREA-----RRRGKAEEQAVRQRELAEQ 1719
A EEV Q + L A+ +KE A RE R R + + QR + +
Sbjct: 2041 ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100
Query: 1720 ELEKQR------QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-- 1771
EL + R L + Q ++ I+ A+ + L ++L L + A
Sbjct: 2101 ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160
Query: 1772 AATQKRQELEAELAKVRAEMEVLLA-SKARAEEESRSTSEKSKQ---RLEAEAGRFRELA 1827
A Q +E+ +AK + E LLA S RA E S+ K +A A R +EL
Sbjct: 2161 AEVQAHEEVMTSVAK---KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217
Query: 1828 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA---------------AIGEA 1872
+ L L + + E++ + + L L +G+A
Sbjct: 2218 DRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDA 2277
Query: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR------------------LEEQAAQH 1914
+++ ++++L+ K + E ++ + + + R LE
Sbjct: 2278 C-IRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336
Query: 1915 KADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1972
+ D + Q ++A L+ K L V+ LR+ ++E E+ ++A E LE
Sbjct: 2337 ELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES-------LE 2389
Query: 1973 LELGRIRSNAEDT---LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE--- 2026
E+GR+ + + LR ++Q E+ Q + A++ R +A + QK A +E
Sbjct: 2390 REVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV 2449
Query: 2027 AARQRKAALEEVERLKAKVEEARRLRE----RAEQES-ARQLQLAQEAAQKRLQAEEKAH 2081
+A++ +A ++ ++ VE R L E +AE +S + LA+ Q+ L A H
Sbjct: 2450 SAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTA---GH 2506
Query: 2082 AF--------------------AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
F A Q+ + +LQQ L+ + + + E + A
Sbjct: 2507 PFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLAS 2566
Query: 2122 EA------------------RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163
E E +A + A L Q +AQ+ A + A
Sbjct: 2567 EGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQS-ALGRCQAM 2625
Query: 2164 KLRKEA--EQEAARRAQAE-----QAALRQKQAADAEM-EKHKKFAEQTLRQKAQVEQEL 2215
LRKEA Q RR + E QA L+ Q A + EK+ E+ L A + +L
Sbjct: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
Query: 2216 T---TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2271
+ +L+ + HQ+ L E QRL A+ + EEL ++ ++++ S+ K
Sbjct: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKV 2745
Query: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
A+++ AL LR EE E + E R Q + +L L Q
Sbjct: 2746 AKLQKACEALRLRRS-------MEELENWLEPIEVELRAPTVGQALPGVGEL----LGTQ 2794
Query: 2332 RALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2388
R L + K+ QA + +A E L Q E EQARRL + + + + L E
Sbjct: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVE---EQARRLLQRFKSLREPLQERR 2851
Query: 2389 QGFQRT---LEAERQRQLEMSAEAERLKLRVAE---MSRAQARAEEDAQRFRKQAEEIGE 2442
+ L+ R EM+ E+L L A+ S + R ++ + + E
Sbjct: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911
Query: 2443 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2502
L R L T K+ Q A + + +LE+ L+ EA +L ++
Sbjct: 2912 ALTRVVLGTGYKLV---------QAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQ 2962
Query: 2503 MQTVQQ--EQLLQETQALQQS--FLSEKD---------SLLQR----ERFIEQEKAKLEQ 2545
Q QQ +LL+ L + L +D +LL+R +R +E ++E+
Sbjct: 2963 AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIER 3022
Query: 2546 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605
L Q + E + Q++ R+ + A R H +E ++ Q E + L
Sbjct: 3023 LQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLL 3082
Query: 2606 QRRQQEELLAEENQRLREQLQ---LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2662
+ E+Q + L+ +LEE+ A + + ++V A + L L+
Sbjct: 3083 DAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG---TLER 3139
Query: 2663 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2722
A P R + + +RL +A E L + H+ A LQGR
Sbjct: 3140 GAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAE-------LQGR 3192
Query: 2723 SSIAGLLLKATN--EKLSVYAALQRQ 2746
L+K + LS LQ+Q
Sbjct: 3193 MQEKTALMKGEDGGHSLSSVRTLQQQ 3218
Score = 67.0 bits (162), Expect = 4e-10
Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)
Query: 371 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 425
+SLE V + P H L +V + W +L +R + L + + + LQ ++
Sbjct: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444
Query: 426 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 485
+L + A Q++ + A + A ++ + E + +LD I L + Q
Sbjct: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500
Query: 486 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 542
L HP + + + L + L ++ E+ L+L+ + Q+ L SV++
Sbjct: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554
Query: 543 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 595
EDS L D LA +E + EW +++ + + A + RGLHQ
Sbjct: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612
Query: 596 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 653
P + A C L + A + + + RL L L +F+ +
Sbjct: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657
Query: 654 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 713
+ WL EK + D + A+ + EL+ + +ELQ G RLL+
Sbjct: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716
Query: 714 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 773
HPA ++ L W L++N+ ++ +LQK EALR
Sbjct: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756
Query: 774 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 828
+ S + LE+ L+ + E Q G L G + +A V K R A
Sbjct: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809
Query: 829 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 888
+ G Q + V +G C L + ++L S
Sbjct: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843
Query: 889 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 948
+ QE T LEA+ +L + D +AW + + + + + +E
Sbjct: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
Query: 949 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1008
Q Q L S ++A R G + A E + ++ + L A
Sbjct: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958
Query: 1009 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1064
+ E + +L + R + LD E + E Q + + +A + ++E
Sbjct: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
Query: 1065 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1124
+ RL A L +P +P + L +L+ VR A L + + RG
Sbjct: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063
Query: 1125 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1181
G +E L+ H+ + +E + A L AT S + + + FDA R E++
Sbjct: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121
Query: 1182 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1233
+++ L++ R ++ R R+ ER QA+ A+T E
Sbjct: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176
Query: 1234 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1289
++ ++++A L R QE+ M D +VR +Q + L E+E
Sbjct: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230
Query: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
++V Q A + QL P A+P KVQ + + +Q R
Sbjct: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273
Query: 1350 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1409
+ ++ E L +E + LA + E E +A E L + +L + +
Sbjct: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331
Query: 1410 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1461
+ QA+ +E QQ + E Q+ + +Q EE LR AE ++
Sbjct: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
Query: 1462 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517
+ QAEA E L+ + V ++L Q +L+ L A EE AQ +
Sbjct: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445
Query: 1518 QAQEEAERL 1526
+ + E E L
Sbjct: 3446 KTEMEQELL 3454
Score = 53.5 bits (127), Expect = 5e-06
Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)
Query: 305 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 364
QL+ + LLL W+ A E + + E +++L +F F+ KE
Sbjct: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122
Query: 365 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 420
+Y + L G ++ G + P +E W +L AI R + L + E
Sbjct: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178
Query: 421 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 477
V Q A + ++ + AL++ + L + + Q+ +ER+L+ + +
Sbjct: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234
Query: 478 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 537
L + L HP +V A + A A + Q Q+
Sbjct: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278
Query: 538 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 597
Q + L Q+LLAW +E Q E D+ E LG H L Q I E R
Sbjct: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333
Query: 598 KIERARSDEGQL 609
+ + R + QL
Sbjct: 3334 QAQDLRQEGQQL 3345
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 352 bits (902), Expect = 6e-96
Identities = 484/1900 (25%), Positives = 851/1900 (44%), Gaps = 251/1900 (13%)
Query: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
R +D F P DR + E E G Q Q QE+ R EL + Q E
Sbjct: 114 RQEEDQRRFEPRDRQL-EEEPG----------QRRRQKRQEQER------ELAEGEEQSE 156
Query: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
E R R R D+E R+ Q E+++ +AE E L S + + P+
Sbjct: 157 KQE-RLEQRDRQRRDEELWRQ-RQEWQEREERRAEEEQL------QSCKGHETEEFPDEE 208
Query: 1085 PAAPTLRSELELTLGKLEQVRS-----LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1139
R LEL E+ + ++ E+ + + + E VLR EE+L
Sbjct: 209 QL--RRRELLELRRKGREEKQQQRRERQDRVFQEEEE------KEWRKRETVLRKEEEKL 260
Query: 1140 KEAQAVPATLPELEATKASLKKL-RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1198
+E + P EL+ + L+KL R + ++ + + LR Q++ + ++ E+
Sbjct: 261 QEEE--PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1258
E +ER Q ER + L + +RE +QL R+ R L ++ RR Q+
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERRE-QQLRREQEEERRE-QQLRREQEEERREQQ 376
Query: 1259 QIQAMPLADSQAVR--EQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYELQLV 1314
+ L Q +R +QLR+EQ L E + R + E Q +Q + ++ E
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE---- 432
Query: 1315 TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR---- 1370
++ + E + + Q ++ + H E Q +K E RR
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE---RRKQQLKRDQEEERRERWL 489
Query: 1371 -MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
+EEEER +Q+R E++ R + E ++ +RQ E Q + ++E++ + Q+ +E++
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 1429 VRREEAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-VRL 1486
++REE +KR QE +Q L++ E ++ E + RL+ E+E R+ RL
Sbjct: 550 LKREE-------EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 1487 QLEATERQRGGAEGELQALRARAEEAEAQKRQ----AQEEAERLRRQVQDESQRKRQAEV 1542
+ E ER + E + R + EE E ++RQ ++E+ ER ++Q++ E Q +R+
Sbjct: 603 KREEVERLE---QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE--- 656
Query: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ-VQVALETAQRSA 1601
R+K E E R +QR + EE E E+ L + E E+AR+ ++ + Q
Sbjct: 657 ---QRLKREEEEERLEQRLKREHEE-----ERREQELAEEEQEQARERIKSRIPKWQWQL 708
Query: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-R 1660
E+E ++++ + + E + + + R E+E + Q++ A R ++E E+ +
Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768
Query: 1661 WQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQK--------EEAEREARRRGK---- 1705
WQ +A E R RL A +++ Q AE+++ EE E+E RRR +
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 1706 ------AEEQAVRQRELAEQELEKQRQLAEGTAQQ-----------RLAAEQELIRLR-- 1746
EE+ +++RE A+Q E++ L E ++ R E+E R R
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 1747 -----AETEQGEQQRQLLEEELARLQREAAAATQKRQELE---AELAKVRAEMEVLL--- 1795
A EQ +++QLL+EE LQRE ++RQE E E +++ E E LL
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQRE-EREKRRRQEQERQYREEEQLQQEEEQLLREE 947
Query: 1796 ASKARAEEESRS--TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEE 1849
K R +E R +K +Q+ E G E R + EE + Q++ L EE
Sbjct: 948 REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-- 1907
R+R E ER +K E +L E +EK ER R+ E+E Q+
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREE----REKRRLQERERQYREEEELQQEEEQL 1063
Query: 1908 --EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965
EE+ + + ++E Q RK + + E ++ L E+ ++RRQ E + E+
Sbjct: 1064 LGEERETRRRQELER---QYRKEEELQQEEEQLLREEPEKRRRQERERQCREE---EELQ 1117
Query: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2025
+ +L E R E + +E+ E++ ++ L E E+RRR+ ER + EE
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR----EE 1173
Query: 2026 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---RLQAE-EKAH 2081
E +Q + L E+ K + E R+ RE E + ++ Q ++ Q+ + Q E EK +
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Query: 2082 AF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
A V K +E +Q Q E S L + + + E+ E R Q R Q R
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293
Query: 2139 EEAERLKQSAEEQAQAR-AQAQAAAEKLRKEAE-----QEAARRAQAEQAALRQKQAAD- 2191
E E+L++ +++A+ R ++Q + LR+E E QE R+ + E+ L++++
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251
E+ +KF E+ LR + Q + L +L + ++ L EE Q+L+ + E +Q
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEE-EQRLRRQERERKFLKEE-QQLRCQ--EREQQLR 1409
Query: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEA 2307
Q + F R + ++LS+ + + +R ++ ++FL+EE E+ ++ EE
Sbjct: 1410 QDRDRKF--REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467
Query: 2308 ARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQ 2361
L ++ R R+ EE+ +R ++ +E+ QE R L+ E +L +Q
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527
Query: 2362 QKE---LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2418
Q++ L +EQ R QE +Q Q + + ++ + ++QL + +L +
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587
Query: 2419 MSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2476
+ R + + ED Q+ R+Q + + R +++ Q L+ + +Q H ER R
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE----QLLQEREEQQLHRQERDR 1643
Query: 2477 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-------QSFLSEKDSL 2529
+ LE E + +QE + + + ++EQLLQE + Q + F E+ L
Sbjct: 1644 KF---LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 2530 LQRER---FIEQE----KAKLEQLFQDEVAKAQQLREEQQRQQQQ----MEQERQRLVAS 2578
++ER F+++E + +LE+ F++E Q+ +EQ R+Q++ +E+E+ R
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 2579 MEEARRRQHE---AEEGVRRKQEELQQLEQQR-----RQQEELLAE-ENQRLR------- 2622
++ RR++ + EE R++ E QQL Q R++E+L E E Q+LR
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820
Query: 2623 -----EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2677
EQLQL E++ R + A + AT+ E E + R
Sbjct: 1821 YRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE--------KSRREEQELWQEEEQKR 1872
Query: 2678 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2717
R+ ++L+E I Q+ Q H V E+ +E H
Sbjct: 1873 RQERERKLREEHI---RRQQKEEQRHRQVGEIKSQEGKGH 1909
Score = 346 bits (888), Expect = 3e-94
Identities = 429/1702 (25%), Positives = 734/1702 (43%), Gaps = 233/1702 (13%)
Query: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1215
K SL + R Q E Q+ F+ +L +E G+R +Q+ E++ E+ E+ +
Sbjct: 106 KESLLQDRRQEEDQR-RFEPRDRQLE--EEPGQRRRQKRQEQERELAEGEEQSEK----- 157
Query: 1216 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV--RE 1273
Q L Q D RQR E+L RQ + ++E ++ R +EQ+Q+ +++ E
Sbjct: 158 QERLEQRD-RQRRDEELWRQRQEWQER--------EERRAEEEQLQSCKGHETEEFPDEE 208
Query: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
QLR+ + L E+ R G + ++ QR +Q
Sbjct: 209 QLRRRELL--ELRRKGREEKQQQRRERQ-------------------------------- 234
Query: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
+ V QE + E T L + K E +R E + EQ R ER+ L
Sbjct: 235 ---DRVFQEEEEKEWRKRE-TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1451
E+Q+Q Q + + E E +E Q+ +E+ RRE+ +QQ R QEE QQ
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350
Query: 1452 LRQSSE---AEIQAKARQAEAAERSRLRIEEEI-------RVVRLQLEATERQRGGAEGE 1501
LR+ E E Q + Q E +LR E+++ R +L+ E R+ E
Sbjct: 351 LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410
Query: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR-EKQ 1559
Q R + E Q R+ QEE ++ Q+ QR ++ + E +K E E R E++
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470
Query: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619
R Q L+ R Q EE R + E E R+ Q E R + E + +R E+ +L
Sbjct: 471 RRKQQLK--RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528
Query: 1620 ERSLQEEHVAVAQL-REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1678
++ L+ E QL RE+ ERR Q E R E ER +R + + E L+ EE
Sbjct: 529 QQRLRSEQ----QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 1679 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1738
+Q+ L + + E+ ++ +RE R + EE+ ++ + E E E+++QL + Q+
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Query: 1739 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
+Q LR E ++ +QR EEE RL+ Q L+ E + R E E+ +
Sbjct: 645 QQ----LRREQQERREQRLKREEEEERLE----------QRLKREHEEERREQELAEEEQ 690
Query: 1799 ARAEEESRSTSEKSKQRLEAEAGR------FRELAEEAARLRALAEEAKRQRQ-----LA 1847
+A E +S K + +LE+EA R +E R R EE +R+R+
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 1848 EEDAARQRAEAE-------RVLAEKLAAIGE-----ATRLKTEAEIALKEKEAENERLRR 1895
EE A RQ+ E E + AE+ + G L+ + E L+ +E + R
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810
Query: 1896 LAEDEAFQRRRLEEQAAQHKADI--EERLAQLRKASDSELERQKGLVEDTLRQRR----- 1948
L E+E ++RR + + + + EE Q R+ + E + GL ED R+R
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Query: 1949 ------QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002
Q+EEE + + A + +L E ++ E+ R + + ++RQ
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 2003 AAEEERRRRE----AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2058
EE+ ++ E EER ++ E R+ K ++ E+L + E RR +ER E++
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER-EKK 989
Query: 2059 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
+ +L QE Q + EK +++ ++ + Q+E+ +L + R + R +
Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049
Query: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
EE +Q E E E R +Q E Q + + Q E+L +E E E RR +
Sbjct: 1050 YREEEELQQEEEQLLGE---ERETRRRQELERQYRKEEELQQEEEQLLRE-EPEKRRRQE 1105
Query: 2179 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
E+ +++ E E+ +K Q L ++ + E+E+ QL + +K +
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR-RRQ 1164
Query: 2235 ELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293
EL+R E E ++ Q + EE R + E + + ++ + R RD+D + L
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ-RSDL 1223
Query: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ-------QRALAEKMLKEKMQ-- 2344
+ + E K+ A ++ +E + RQL + L Q L E+ +++ Q
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 2345 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QR 2401
Q+ R E E L++++ Q++A+R ++ Q L EE + +R E +R +
Sbjct: 1284 RRWQQRDRHFPEEEQLEREE---QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE 1340
Query: 2402 QLEMSAEAERLKLRVAEMSRAQARAE-----------EDAQRFRKQAEEIGEKLHRTELA 2450
+ ++ E E LR E R E E+ QR R+Q E +L
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 2451 TQEKVTLV----------QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2500
QE+ + + ++ RQ+ D + + ERE++ L++E +L Q +
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 2501 EEMQTVQQEQLLQETQALQ-------QSFLSEKDSLLQRER-----------------FI 2536
+ + ++EQLLQE + Q + FL E+ L ++ER F+
Sbjct: 1461 RKFR--EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 2537 EQE-----KAKLEQLFQDEVAKAQQLREEQQRQ--------QQQMEQERQRLVASMEEAR 2583
E+E + + + Q+E +Q R +Q+RQ ++Q+ QER+ S +E
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578
Query: 2584 RRQHEAEEGVRRKQEE---LQQLEQQRRQ--QEELLAEENQRLREQLQLLEEQHRAALAH 2638
R+ E+ VRR+++E ++ +Q RRQ Q++L E +++ RE QLL+E+ L
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 2639 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2698
E + L E + H D R+ Q LQE +R
Sbjct: 1639 QER--------DRKFLEEEPQLRRQEREQQLRHDRDRKFRE-EEQLLQEGEEQQLRRQER 1689
Query: 2699 LAQGHTTVDELARREDVRHYLQ 2720
+ +L R+E R +LQ
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQ 1711
Score = 324 bits (831), Expect = 1e-87
Identities = 430/1733 (24%), Positives = 766/1733 (44%), Gaps = 267/1733 (15%)
Query: 924 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 983
Q LRR+ QL R L + L+ E+Q + L Q LR Q R
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ--LRREQ-----------QLRR 421
Query: 984 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 1043
E Q L + +EE Q+ E ++ RL+ E E R L ++E
Sbjct: 422 E------------QQLRREQEEERHEQKHEQERREQRLKREQEERRD----WLKREEETE 465
Query: 1044 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1103
R +R +Q K E E E+ L L E R E +L + E+
Sbjct: 466 RHEQERRKQQLKRDQEEE-----------RRERWLKLEEEERREQQERREQQLR-REQEE 513
Query: 1104 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1163
R E+ + + +R +E+ LR +E+ +E LE + + R
Sbjct: 514 RREQRLKRQEEEERLQQRLR----SEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Query: 1164 AQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL-------ER 1214
Q E + + R + R +E ERL+QR +VE ER Q L ER
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629
Query: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
Q +L + +R +QL R+ + RE Q +R +E+ + + ++
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERRE---------QRLKREEEE---------ERLEQR 671
Query: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-----K 1329
L++E EE R E EE Q A++ I + ++ ++ QLE A + +
Sbjct: 672 LKREH---EEERREQELAEEEQEQARERIKS------RIPKWQWQLESEADARQSKVYSR 722
Query: 1330 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER- 1388
P+ Q G ++ R SEL + +EEER QQ+ EE+ R
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESEL----------------QWQEEERAHRQQQEEEQRRD 766
Query: 1389 ---LAEVEAALEKQRQLAEAHAQAKAQAERE--AKELQQRMQEEVVRREEAAVDAQQQKR 1443
+ E E+ RQ A + Q ER+ A+E QQR ++ + EE ++Q+R
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR-EQRFLPEEEEKEQRRRQRR 825
Query: 1444 SIQEELQQLRQSSEAEIQAKARQ--------AEAAERSRLRIEEEIRVVRLQLEATERQR 1495
++ELQ L + + + + +A+Q E ER R + + + R QLE ++R
Sbjct: 826 EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885
Query: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
L A A E+ +++ QEE E L+R+ +++ +R+ Q
Sbjct: 886 ---RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ------------ERQY 930
Query: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615
RE+++ Q EE +L EE E+R RQ + R+ + + ++ E + +R EK
Sbjct: 931 REEEQLQQ--EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988
Query: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELERWQLKANEALRLRLQ 1674
+ E LQ+E + LREE E+R +Q+ E + R ++E ++E E+ + E RL+ +
Sbjct: 989 KYREEEELQQEEEQL--LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Query: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734
+ +++ L Q E + E ERE RRR + E Q ++ EL ++E QL ++
Sbjct: 1047 ERQYREEEELQQEEEQLLGE--ERETRRRQELERQYRKEEELQQEE----EQLLREEPEK 1100
Query: 1735 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE---AELAKVRAEM 1791
R E+E + R E E +++ QLL EE + ++RQELE E +V+ E
Sbjct: 1101 RRRQERER-QCREEEELQQEEEQLLREEREK---------RRRQELERQYREEEEVQQEE 1150
Query: 1792 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ---RQLAE 1848
E LL R E E R E +Q E E EL +E +L +E +RQ RQ E
Sbjct: 1151 EQLL----REEPEKRRRQELERQYREEE-----ELQQEEEQLLREEQEKRRQERERQYRE 1201
Query: 1849 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQ 1903
E+ +++ +R E + + + E E A+++ K ENE+ R+L + +
Sbjct: 1202 EEELQRQKRKQRYRDEDQRS-DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL-- 1258
Query: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT-LRQRRQVE-EEILALKASF 1961
R R +Q QH L ++ D E ER++ D + Q+E EE K
Sbjct: 1259 RDRQSQQDLQH-------LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---- 2017
K+ K L E R E + +E+ +L R+ Q +ER R+ EE +
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371
Query: 2018 --QKSLAAEEEAARQRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2073
+K L E+ RQ + L+E ++L+ + E + ++R + + QL+++ ++
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 2074 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR----GEAEAARRAAEEAEEARVQAER 2129
+ EE+ Q + QE ++ +E+ L Q R E E + EE + R + +R
Sbjct: 1432 FREEEQ------QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR-AQAEQAALRQKQ 2188
+ + +Q+ ER ++ E++ +++ + E+ ++ Q+ R+ Q EQ RQ++
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545
Query: 2189 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----AT 2244
++ +KF R++ Q+ QE +L +E D + L +++++R + E
Sbjct: 1546 GQQRRQDRDRKF-----REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 2245 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304
E +R + +++L R + + + ++ E L ++ ++FL+EE + +Q
Sbjct: 1601 EQQLRRQEGQQQL---RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657
Query: 2305 EEAAR--LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362
E+ R +E +L Q EE +++ K +E+ Q+ R + E + LQ++
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE----QQLRRQERERKFLQEE 1713
Query: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2422
++L +++ R ++EQ+ Q+ +E + RQ + E E+L+ E
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQE--------QLRRQERYRKILEEEQLR---PEREEQ 1762
Query: 2423 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2482
Q R +E ++FR++ E++ ++ +L +QE + + E+LR+
Sbjct: 1763 QLRRQERDRKFREE-EQLRQEREEQQLRSQES-----------DRKFREEEQLRQ----- 1805
Query: 2483 EREKEKL--QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2540
ERE+++L QQ + + E++Q +QEQ L++ + Q E+F QEK
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR---------AEEQFATQEK 1856
Query: 2541 AKLE--QLFQDEVAKAQQLREEQQRQQ----QQMEQERQRLVASMEEARRRQH 2587
++ E +L+Q+E K +Q RE + R++ QQ E++R R V ++ + H
Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGH 1909
Score = 321 bits (822), Expect = 1e-86
Identities = 344/1299 (26%), Positives = 606/1299 (46%), Gaps = 105/1299 (8%)
Query: 1408 QAKAQAEREAKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1464
+ +A+ + + LQ R QEE RR + ++ + +R Q+ +Q R+ +E E Q++
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE- 156
Query: 1465 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEA 1523
+Q +R R R +EE+ R + + E +R E +LQ+ + EE +++ + E
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERR-AEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1583
LRR+ ++E Q++R+ E RV E E ++R +E E +L++ E
Sbjct: 216 LELRRKGREEKQQQRR---ERQDRVFQEEEEKEWRKRETVLRKE--------EEKLQEEE 264
Query: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643
+R R++Q E ++ EL+ +R ++ +L R Q + RE+ E R +Q
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
Q E+ E E++L R Q + E R Q EE +Q+ + E E+++++ RE + R
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 1704 GKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLEE 1761
E+Q R+++L EQ+L +++QL +Q+L EQ+L R + EQ E++ + E
Sbjct: 385 --REQQLRREQQLRREQQLRREQQLRR---EQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
+ R QR ++R L+ E R E E R +EE R + +LE E
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER---RERWLKLEEEER 496
Query: 1822 RFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879
R ++ E +LR EE + QR + EE+ +QR +E+ L + E LK E
Sbjct: 497 REQQERRE-QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL-LKREE 554
Query: 1880 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQK 1937
E L E+E +RL+R E+ Q + EE+ Q K + EERL Q K + E Q+
Sbjct: 555 EKRL-EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------IRSNAEDTLRSKEQ 1991
E L++ EE L S E+ + +L E R E+ L + +
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673
Query: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAA-EEEAARQRKAALEEVERLKAKVEEARR 2050
E E R+ Q AEEE + +A ER++ + + + + A +V K E RR
Sbjct: 674 REHEEERREQELAEEE--QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 2051 LRERAEQESARQLQL---AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
+E+ E+ R+ +L +E A ++ Q EE+ F Q + +E + +Q S LR
Sbjct: 732 RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLR 791
Query: 2108 GEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAAAE 2163
+ E RA E + E+ + E E Q RRQ E E+ Q EEQ Q R +AQ E
Sbjct: 792 EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Query: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQVEQELTTLRLQ 2221
+ E + RR+Q ++ + + + E + +H +A+ L+++ + EQ+L LQ
Sbjct: 852 EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL----LQ 907
Query: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
EE + Q+ +E +R + E R+ Q+++E + + E + + R +
Sbjct: 908 EEEEELQR---EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341
L+ K+ ++ L EE EK ++ E + + L EE ++R E+ ++
Sbjct: 965 KLQQKE--EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 2342 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE--QMAQQLAEETQGFQRTLEAER 2399
K + QE +L E +++K QE+ R+ +E++E Q +QL E + +R E ER
Sbjct: 1023 KDELQQEEEQLLRE----EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 2400 Q--RQLEMSAEAERLKLRVAEMSR-----AQARAEEDAQRFRKQ-AEEIGEKLHRTELAT 2451
Q ++ E+ E E+L E R Q R EE+ Q+ +Q E EK R EL
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2511
Q + E ++ + +R R+ + RE+E+LQQE + L + +E + ++E+
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 2512 LQETQALQQ------------------SFLSEKDSLL----------QRERFIEQEKAKL 2543
+E + LQ+ + EK++ + + E+F + E ++L
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258
Query: 2544 --EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
Q QD + +E + Q+++ Q+R R E+ R + + + RK +E +
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Query: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2640
QL ++ R+++ E +++ RE+ QLL+E+ L E
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Score = 311 bits (797), Expect = 9e-84
Identities = 327/1201 (27%), Positives = 577/1201 (48%), Gaps = 139/1201 (11%)
Query: 1496 GGAEGELQALRARAEEAEA--QKRQAQEEAERLR---RQVQDESQRKRQAEVELASRVKA 1550
G A G + RAR + E+ Q R+ +E+ R RQ+++E ++R+ + + R A
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 1551 EAEAAREKQRALQAL------EELRLQAEE-AERRLRQAEVERARQVQVALETAQRSAEA 1603
E E EKQ L+ EEL Q +E ER R+AE E+ + + ET + E
Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK-GHETEEFPDEE 208
Query: 1604 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1663
+L+ + + +L R +EE Q RE +R Q++ E E + E E +L
Sbjct: 209 QLRRR------ELLELRRKGREE--KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260
Query: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
+ E R R EE Q + L + E ++++E E++ +R + ++ +Q E ++ E+
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1783
+R+ E QQ EQ+L R +Q + E++L R Q E Q R+E E E
Sbjct: 321 RREQQERREQQEERREQQLRR---------EQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 1784 LAKVRAEMEVLLASKARAEEESRSTSE-KSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1842
R E ++ + R E++ R + + +Q+L E RE ++ R + L E +
Sbjct: 372 ----RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLRREQQL 425
Query: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDE 1900
+R+ EE+ Q+ E ER ++L E R LK E E E+E ++L+R E+E
Sbjct: 426 RRE-QEEERHEQKHEQER-REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE 483
Query: 1901 AFQR-RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1959
+R +LEE+ + + E R QLR+ + E+ R +RQ EEE L +
Sbjct: 484 RRERWLKLEEE--ERREQQERREQQLRREQEERREQ---------RLKRQEEEERLQQRL 532
Query: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ-LAAEEERRR----REAE 2014
E+ + E E L+ +E+ LE R+ Q L E+E RR + E
Sbjct: 533 RSEQQLRREQE---------ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2074
ER Q+ L E+E +++ EEVERL+ + +RL+ +E RQ L E ++R
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQ 2133
Q + + QQ+ +E + ++E+ L+Q L+ E E RR E AEE + QA RE +
Sbjct: 644 QQQLRRE----QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA-RERIK 698
Query: 2134 SR--RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191
SR + + E + + + +R + Q E R+ EQE RR + + ++++ A
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQ---EGQRRRQEQEEKRRRRESELQWQEEERAH 755
Query: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251
+ ++ ++ + T + +A+ + E RL + L ++ ++L+AE + QR
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSA-----RPPLREQRERQLRAEERQQREQRF 810
Query: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR-----FLQEEAEKMKQVAEE 2306
EEE E+ + + R E E L +++ QR LQEE + +++ ++
Sbjct: 811 LPEEE--------EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE--DQ 860
Query: 2307 AARLSVAAQEAARLRQLAEEDLAQQR-------ALAEKMLKEKMQAVQEATRLKAEAELL 2359
R S + + R EE+ ++R AL E++ KE+ +E L+ E
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE---- 916
Query: 2360 QQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
+++K QEQ R+ +E++ +Q +QL E + +R E ERQ + + + + +L
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGE 976
Query: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
E + + + E R ++ ++ E+L R E + + Q E Q ++ D + ++ E
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR----QEWERQYRKKD-ELQQEEE 1031
Query: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
+ EREK +LQ+ + Q + EE ++EQLL E + ++ E + ++E ++
Sbjct: 1032 QLLREEREKRRLQERER--QYREEEELQQEEEQLLGEERETRRR--QELERQYRKEEELQ 1087
Query: 2538 QEKAKLEQLFQDEVAK-AQQLREEQQRQQQQMEQERQRLVASMEEARR-----RQHEAEE 2591
QE+ EQL ++E K +Q RE Q R++++++QE ++L+ E RR RQ+ EE
Sbjct: 1088 QEE---EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 2592 GVRRKQEEL----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2641
V++++E+L Q+LE+Q R++EEL EE Q LRE+ + ++ EE
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 2642 V 2642
+
Sbjct: 1205 L 1205
Score = 217 bits (553), Expect = 2e-55
Identities = 251/968 (25%), Positives = 440/968 (45%), Gaps = 145/968 (14%)
Query: 1868 AIGEATRLKTE-------AEIALKEKEAENERLR-----RLAEDEAFQRRRLEEQ----- 1910
A+G+AT L E E L+++ E ++ R R E+E QRRR + Q
Sbjct: 88 ALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERE 147
Query: 1911 --AAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1967
+ +++ +ERL Q R+ D EL RQ+ ++ +RR EE++ + K +
Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER-EERRAEEEQLQSCKGHETEEFPD 206
Query: 1968 KAEL-ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAE 2024
+ +L EL +R R ++Q + + R EEE+ R+RE R ++ E
Sbjct: 207 EEQLRRRELLELRRKG----REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
Query: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----QLQLAQEAAQKRLQAEEK 2079
EE RQR+ EE + K + +E RR R+ EQ+ R QL+ QE ++ Q E +
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 2080 AHAFAVQQKEQELQQTLQQEQSVL--DQLRGEAEAARR----AAEEAEEARVQAEREAAQ 2133
+Q+E+ +Q L++EQ QLR E E RR E+ EE R Q R Q
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 2134 SRRQ-----------VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---------- 2172
RR+ ++ R +Q EQ R Q ++LR+E E+E
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 2173 AARRAQAEQAALRQKQAADAEMEKH-KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
+R + EQ R + E E+H ++ +Q L++ + E+ L+L+ EE Q+
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502
Query: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
+++L+R + E E +R + EE R+Q S+ + R E E R L ++ +R
Sbjct: 503 REQQLRREQEERREQRLKRQEEEE-----RLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Query: 2292 FLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-- 2348
QE E ++K+ EE + +E R ++L E Q+ L +++ +E+++ +++
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKRE---QEERLEQRLKREEVERLEQEE 614
Query: 2349 --ATRLKAE-------AELL--QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
RLK E +LL ++Q+E Q+Q RR Q+++ + + EE + ++ L+
Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674
Query: 2398 ERQ---RQLEMSAE-----AERLKLRV------------AEMSRAQARAEEDAQRFRKQA 2437
E + R+ E++ E ER+K R+ A S+ +R + + R+Q
Sbjct: 675 EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734
Query: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ---QEAK 2494
+E + +EL QE+ + + + Q+ D + E +E R++ + +E +
Sbjct: 735 QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR 794
Query: 2495 LLQLKSEEMQTVQQEQLLQETQALQQ-----------SFLSEKDSLLQRERFIEQEKAKL 2543
QL++EE Q +Q L +E + Q+ FL E++ L +RER +Q + +
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRER-AQQLQEEE 853
Query: 2544 EQLFQDEVAKAQQLREEQQRQQQQMEQERQR-------LVASMEEARRRQ---HEAEEGV 2593
+ L +D+ + Q + Q+ + Q+E+ER+R A E+ R+ Q E EE +
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Query: 2594 RRKQEE---LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650
+R++ E Q+ E+Q R++E+L EE Q LRE+ + Q R Q
Sbjct: 914 QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER----------ERQYRKD 963
Query: 2651 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ----GHTTV 2706
K L + L G E + R+ + +E +L E +R Q +
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 2707 DELARRED 2714
DEL + E+
Sbjct: 1024 DELQQEEE 1031
Score = 96.3 bits (238), Expect = 6e-19
Identities = 86/335 (25%), Positives = 166/335 (49%), Gaps = 42/335 (12%)
Query: 2299 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2358
K+ Q A + E R R +E L Q R +E+ Q E + E E
Sbjct: 80 KVAQACYYALGQATGLDEEKRARCDGKESLLQDRR------QEEDQRRFEPRDRQLEEEP 133
Query: 2359 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2418
Q++++ QEQ R L E +EQ +Q +R + +RQR+ E E + R
Sbjct: 134 GQRRRQKRQEQERELAEGEEQSEKQ--------ERLEQRDRQRRDE-----ELWRQRQEW 180
Query: 2419 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2478
R + RAEE+ + K E E +E++ + LE++R+ + ++ RE
Sbjct: 181 QEREERRAEEEQLQSCKGHET-------EEFPDEEQLRRRELLELRRKGREEKQQQRRE- 232
Query: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2538
++++ QE + + + E ++E+ LQE + +Q L E++ L++ +E+
Sbjct: 233 ------RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK---LER 283
Query: 2539 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2598
++ + E+ Q+E + Q+LR EQQ +++Q E+ R++ EE R +Q E+ R+++
Sbjct: 284 QELRRER--QEEEQQQQRLRREQQLRRKQEEERREQ----QEERREQQERREQQEERREQ 337
Query: 2599 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2633
+L++ +++RR+Q+ +E +R +QL+ +E+ R
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Score = 37.4 bits (85), Expect = 0.35
Identities = 73/313 (23%), Positives = 122/313 (38%), Gaps = 57/313 (18%)
Query: 408 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 467
E+QL+ E E+L +R + Q E Q + L Q + +LL G+ P++ ER
Sbjct: 933 EEQLQQEEEQLLREEREKRRRQER----ERQYRKDKKLQQKEEQLL--GEEPEKRRRQER 986
Query: 468 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 527
+ K L + Q L++ R + Q + R YR + L E LR
Sbjct: 987 E-KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ-EEEQLLR--------- 1035
Query: 528 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 587
+ + LQ +R+ E+ + + LL E + R + +E Q
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE----------LERQYRKEEE 1085
Query: 588 LHQSIEEF-RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK--LLNSSKARLRSLES 644
L Q E+ R + E+ R E + R C +LQ + LL + + R E
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERE---------RQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 645 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 704
+ +EEEEV + ++E +ELE + ++ +ELQ
Sbjct: 1137 ERQY-------------REEEEV-----QQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 705 AGDRLLREDHPAR 717
++LLRE+ R
Sbjct: 1179 EEEQLLREEQEKR 1191
>gi|156104874 envoplakin [Homo sapiens]
Length = 2033
Score = 350 bits (899), Expect = 1e-95
Identities = 430/1813 (23%), Positives = 770/1813 (42%), Gaps = 258/1813 (14%)
Query: 421 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 480
L +++++Q A E + + LQ D + Q E R L +A+ +++ LF
Sbjct: 39 LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98
Query: 481 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 540
DV + +HPQ E++ + + +LHER+ EY + V P
Sbjct: 99 LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147
Query: 541 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600
P ++ + + +E+ Q +V ++G + +E Q+ H L + I+ + ++
Sbjct: 148 -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196
Query: 601 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660
RS G + R YRD LL ++ R +SL SL++ + T++L L
Sbjct: 197 --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243
Query: 661 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 719
E++ + DWSD + + Y + EL +E+ + +L++ G+R++ HPA
Sbjct: 244 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303
Query: 720 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 779
+++ Q AL+ +W L LC C E L+ Y +F + L KL L KYS
Sbjct: 304 IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363
Query: 780 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 839
+LLQ + E+++L + L +R++ V L R +P + L + ++
Sbjct: 364 PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421
Query: 840 CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 899
CD+ EV + +G+ +LV P W V G P+ CF +P P+ +A +RL
Sbjct: 422 CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481
Query: 900 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 959
++ QAL + +K+ A +SLR Q LA P+ Q+ L
Sbjct: 482 ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535
Query: 960 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1019
G G +R Q L SR + L+D+
Sbjct: 536 -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562
Query: 1020 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1078
++ + E L +KE A +EC ++ + A L
Sbjct: 563 EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604
Query: 1079 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1137
LP + S++++ L L ++ +A+ LE+ ++ VIRG E
Sbjct: 605 QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653
Query: 1138 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1197
L + +PA L+ + L++ R + QQ L L+ ++ LQ E
Sbjct: 654 TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713
Query: 1198 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1257
++ R + +V L +R+ AV Q D+R++ ++ + ++ D L +WL+ R
Sbjct: 714 CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772
Query: 1258 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1317
Q P + +L+ ++ L +EI+ ++ A++DYELQ TY+
Sbjct: 773 ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829
Query: 1318 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI------------KF 1363
LEP S K+P+V ES+ + +L Y+E+ Q + K
Sbjct: 830 CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKE 889
Query: 1364 ISETLRRMEE-------------EERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQA 1409
+SE +RR + E + Q EER+R+A V+ LE QR QL + Q
Sbjct: 890 LSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQ- 948
Query: 1410 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469
R + L+++ E R + + K ++EE ++ R +A+++ A++
Sbjct: 949 -----RPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR-RAGLQADLEVAAQKVVQ 1002
Query: 1470 AERSRLRIEEEIRVVRLQLEATERQRG-GAEGELQALRARAEEAEAQKRQAQEEAERLRR 1528
E R ++ + L E T+ +R G + + LR + ++ + E L++
Sbjct: 1003 LESKRKTMQPHL----LTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKK 1058
Query: 1529 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
++ + KR+ +V+ VK E + ++A + LRLQ EE R +QAE E
Sbjct: 1059 ELL--ALEKREVDVKEKVVVK-EVVKVEKNLEMVKAAQALRLQMEEDAARRKQAE-EAVA 1114
Query: 1589 QVQVALETAQRS----------AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1638
++Q +E +R+ E + + +++++L L+EE A L E
Sbjct: 1115 KLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELS 1174
Query: 1639 RRAQQQAEAERAREEA---ERELERWQL---KANEALRLRLQAEEVAQQKSLAQAEAEKQ 1692
+ + E+ R + ER E +Q+ E RL+ + +E+A ++S + E EK
Sbjct: 1175 DLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234
Query: 1693 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
+ E +A++ V +E+ ++ + +R +E+ RL+A+ +
Sbjct: 1235 LPDLEVL-----RAQKPTVEYKEVTQEVVRHERS---------PEVLREIDRLKAQLNEL 1280
Query: 1753 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
+E+L RLQ E R E E RA++E SK E
Sbjct: 1281 VNSHGRSQEQLIRLQGE-------RDEWRRE----RAKVETKTVSKEVVRHEKDPV---- 1325
Query: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1872
LE EA R R+ EAA+ R AE+A + Q R++ E + V+ E +
Sbjct: 1326 ---LEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV----- 1377
Query: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER--LAQLRKASD 1930
T+ + L+E E+ RL ++E +RR+LE + Q +A +EE+ L ++
Sbjct: 1378 ----TQKDPKLRE---EHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRS 1430
Query: 1931 SELERQKGLVEDTLR-----------QRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979
+L ++ L + TLR Q + + EE++ L+ + + +A L +L + +
Sbjct: 1431 KKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEA-LRWDLDQEK 1489
Query: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2039
+ + R + +++ ++ ++E+ +E RVQK E+E AR + E
Sbjct: 1490 TQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEV-IRVQKDRVLEDERARVWEMLNRERT 1548
Query: 2040 RLKAKVEEARRLRERAEQ---------ESARQLQLAQEAAQK---RLQAEEKAHAFAVQQ 2087
+A+ EEARRLRER ++ +LQ A++ A + RLQ E +A
Sbjct: 1549 ARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRA------L 1602
Query: 2088 KEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--- 2143
+ Q+ QQTLQ QE+S L + E+E + A E +R++A + + Q+ E ER
Sbjct: 1603 ERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEA--AILREKDQIYEKERTLR 1660
Query: 2144 ---LKQSAEEQAQ 2153
K S EE +Q
Sbjct: 1661 DLHAKVSREELSQ 1673
Score = 264 bits (675), Expect = 1e-69
Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)
Query: 4148 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4207
+ ++ ++T ++ + ++ I++PETGK+MS YEAY++G+ID YL+L E EC+WEE
Sbjct: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725
Query: 4208 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4267
+T S G +S+++DR+SG+QY I+ A+ I + Y+ G L I+EFA +++G
Sbjct: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784
Query: 4268 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4322
S S S+GS S S SPA T S S +++ P+AGI DT T K SI
Sbjct: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842
Query: 4323 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4382
A+ +N++D ITGQ+LLEAQA TGGI+D + ER+ V A+ +GL++ R+ AQKA
Sbjct: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902
Query: 4383 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4442
F G EDP TK ++S +A++KGW+ E+ L+VQ+LTGGLI+P GR+P+ +AL G
Sbjct: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962
Query: 4443 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4502
+ AQ L+D +Y K LT P +K ++SYK+A+ R + +GL LL AA + + Y
Sbjct: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022
Query: 4503 S 4503
S
Sbjct: 2023 S 2023
Score = 260 bits (664), Expect = 3e-68
Identities = 458/2092 (21%), Positives = 840/2092 (40%), Gaps = 324/2092 (15%)
Query: 1061 EGLGKGV-ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTIS 1119
+GL KG + S + P+ SP+ + + EL L + + + L+T
Sbjct: 3 KGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQANADQVERDILETQK 62
Query: 1120 LVIRGTQGAEEVLRAHEEQ-----LKEAQAVPATL------------PELEATKASLKKL 1162
+ + +E+ +Q LKEA+ + L P+ E + +K+L
Sbjct: 63 RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122
Query: 1163 RAQAEAQQPTFDALRDELRGAQEVGER------LQQRHGERDVEVERWRERVAQLLERWQ 1216
+ + + AL +++ +VG R L+Q+ ++ V ++ +A+L ++
Sbjct: 123 HERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQK--QKQVCAGQYGPGMAELEQQ-- 178
Query: 1217 AVLAQTDVRQRELEQLGRQLR------------YYRE---------------------SA 1243
+A+ ++ Q+E++ G+QLR YR+
Sbjct: 179 --IAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCT 236
Query: 1244 DPLGAWLQDARRRQEQIQAMPLADSQAVR---------EQLRQEQALLEEIERHGEKVEE 1294
L A + RR +Q + +AD VR E L QEQ++ ++E GE++ E
Sbjct: 237 RQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSV-NQLEDDGERMVE 295
Query: 1295 CQRFAKQYINAIKD---YELQ-----LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1346
+ A I A ++ E Q + + QL+ V + Q ++SV Q L
Sbjct: 296 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRR---FQEEADSVSQTLAKL 352
Query: 1347 RTHY-SELTTLTSQYIKFISETLRRME-EEERLAEQQRAE-ERERLAEVEAALEKQRQLA 1403
++ ++ + +E L+++E EE+RLA +RA + +R + A L ++R
Sbjct: 353 NSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPP 412
Query: 1404 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463
+ + + ++ E+Q E R + + +Q + +++ A
Sbjct: 413 QQPLHVDSICDWDSGEVQLLQGE----RYKLVDNTDPHAWVVQGPGGETKRAPAACFCIP 468
Query: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATE-RQRGGAEGELQALRARAEEAEAQKRQAQEE 1522
A +A R+ R+ E++ ++ +L + R + A L+ + ++ QAQ+
Sbjct: 469 APDPDAVARAS-RLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKL 527
Query: 1523 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE---------ELRLQAE 1573
++ R D Q +RQ V A A A + L+ LE RLQ+
Sbjct: 528 LTQMTRLDGDLGQIERQ--------VLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSL 579
Query: 1574 EAERRLRQAEVER----------ARQVQVALETAQRSAEAELQSKRASFAEKTA---QLE 1620
E+ Q E E A Q+ VAL + + +++Q + + EK LE
Sbjct: 580 GTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKNKF-SDVQVLCSLYGEKAKAALDLE 638
Query: 1621 RSLQEEHVAV----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676
R +Q+ + A L +EA A+ A ER +E + +R +L + LRL
Sbjct: 639 RQIQDADRVIRGFEATLVQEAPIPAEPGALQERV---SELQRQRRELLEQQTCVLRLHRA 695
Query: 1677 EVAQQKSLAQAEAEKQK--EEAEREARR------RGKAEEQAVRQRELAEQELEKQRQLA 1728
A + + A + Q+ ++ R+ R+ R A + RE Q+ Q
Sbjct: 696 LKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQF 755
Query: 1729 EGTAQQRLAAEQELIRLRAETEQGEQQ-------RQLLEEELARLQREAAAATQKRQELE 1781
+ + + L R + G Q ++ L +E+ +R+ A A+ Q L+
Sbjct: 756 KNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQ 815
Query: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
A L + + S E + + S + R+ + A+E +A E A
Sbjct: 816 AALQDYELQADTYRCSL----EPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAA 869
Query: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Q+QL ++ ++ ++ L+E + +A + A +E EA +L + A
Sbjct: 870 AQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVA 929
Query: 1902 FQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE---ILAL 1957
+ LE Q +Q + + L +L + E R L R + QVEEE L
Sbjct: 930 RVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGL 989
Query: 1958 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA-----ARQRQLAAEEERRRRE 2012
+A E AA +LE + R + L +KE ++E ++ QL + ++ R E
Sbjct: 990 QADLEVAAQKVVQLESK----RKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGE 1045
Query: 2013 AE------ERVQKSLAAEE--EAARQRKAALEEVERLKAKVE---EARRLRERAEQESAR 2061
E ++K L A E E + K ++EV +++ +E A+ LR + E+++AR
Sbjct: 1046 DAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAAR 1105
Query: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
+ Q + A+ + + E+ A + + + +++ + EQ L E+ R EE
Sbjct: 1106 RKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQD--PGLLQESSRLRSLLEEER 1163
Query: 2122 EARVQAEREAAQ--SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2179
RE + S+ V E +R K +E+ Q E EQE R
Sbjct: 1164 TKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDP-------ETEQEITRLKAK 1216
Query: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2239
Q ++ + E+EK E QK VE + T + E + + E+ RL
Sbjct: 1217 LQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPE---VLREIDRL 1273
Query: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILRDKDNTQRFLQEEA 2297
KA+ E + +E+L ++ + +E + +A++E + ++ ++ +KD L++EA
Sbjct: 1274 KAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPV---LEKEA 1330
Query: 2298 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357
E+++Q EAA+ AA++A +L +R L E+ E+ VQE + + +
Sbjct: 1331 ERLRQEVREAAQKRRAAEDAVY-------ELQSKRLLLERRKPEEKVVVQEVVVTQKDPK 1383
Query: 2358 LLQQQKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413
L ++ L+ +E RR Q + E + E Q + + +R ++L + E +L
Sbjct: 1384 LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLT 1443
Query: 2414 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2473
LR+ E+ K+ + EK+ E+ EK LE + D +
Sbjct: 1444 LRIQELE--------------KRPPTVQEKIIMEEVVKLEKDP---DLEKSTEALRWDLD 1486
Query: 2474 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2533
+ + + EL RE + LQ + +LQ + +T+ +E + + + + + +L RE
Sbjct: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRE 1546
Query: 2534 RFIEQEKAKLEQLFQDEVAKAQQL-----REEQ--QRQQQQMEQERQRLVASMEEARRRQ 2586
R Q + + + ++ + +A+ L REE QR + Q +QE RL +E R +
Sbjct: 1547 RTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRL---QQELRALE 1603
Query: 2587 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL--------REQLQLLEEQH------ 2632
+ ++ + QEE + L Q+ + + A+ Q L RE+ Q+ E++
Sbjct: 1604 RQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLH 1663
Query: 2633 ----RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG------------- 2675
R L+ + + ++ ++ D EA D
Sbjct: 1664 AKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDW 1723
Query: 2676 ---------------LRRKVSAQRLQEAGI----LSAEELQRLAQGHTTVDELARREDVR 2716
L RK Q EA + +S EE GH + E A
Sbjct: 1724 EEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGE 1783
Query: 2717 HYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT 2776
SI ++ K+ L+ A SP +L L + + D + + +
Sbjct: 1784 TKPSSSLSIGSIISKSP---LASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCS 1840
Query: 2777 VNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQ 2836
+ AV + ++ P KLL A+ A G D + ++ S+ +AM++GLI RLL AQ
Sbjct: 1841 IKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQ 1900
Query: 2837 IA--------------------------------------TGGVIDPVHSHRVPVDVAYR 2858
A TGG+IDP + R+P+ A
Sbjct: 1901 KAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALL 1960
Query: 2859 RGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLP 2910
G EE+ ++L D S K DP + E L+Y + + RC +DP +GL LLP
Sbjct: 1961 SGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
Score = 215 bits (548), Expect = 7e-55
Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)
Query: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1656
R+A EL + Q+ER + E + Q L E + Q Q E R+ +EAE
Sbjct: 33 RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92
Query: 1657 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1715
L+ L ++A RL+ QAEE+ +K + Q +E AE A V R
Sbjct: 93 LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150
Query: 1716 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774
+ LE KQ+Q+ G +A E EQ + +L++E+ A
Sbjct: 151 DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194
Query: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1823
Q R + + A +R++ LL + + + +R S ++Q+ +
Sbjct: 195 QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254
Query: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1878
+L + A +R E K+ L++E + Q + ER++ + A+G LK E
Sbjct: 255 SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314
Query: 1879 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1938
+ L + +L+ + + RR +E+A + + LA+L D++ G
Sbjct: 315 WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365
Query: 1939 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1995
L Q+ + EE+ LA+ ++ L + R+ + L + +
Sbjct: 366 GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425
Query: 1996 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 2025
+ + L E E +R A + V ++ LA+E
Sbjct: 426 SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485
Query: 2026 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2085
+A +Q+ A ++ RLKA E+ R ++A S LA AQK L +
Sbjct: 486 QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539
Query: 2086 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
Q + Q L + + L+ L G E A R + E+ Q E EA S R V
Sbjct: 540 QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599
Query: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198
A A + + L E +A+A RQ Q AD +
Sbjct: 600 GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651
Query: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2251
E TL Q+A + E L+ ++ E Q+ L E+ + LKA A ++
Sbjct: 652 ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708
Query: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2311
+E + Q ++ L R A L LR+K +Q+ A +Q LS
Sbjct: 709 NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763
Query: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371
+ R Q+ D Q A + K Q +Q R +A A L Q + A Q
Sbjct: 764 SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821
Query: 2372 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2431
LQ D + + + +R A Q ++ A+ + L E++ AQ + + +
Sbjct: 822 ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879
Query: 2432 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2487
RK E E+ E + RT HDA++ E+ A+ RE E
Sbjct: 880 FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917
Query: 2488 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2544
+L++E K + E++ Q+ QLLQ L EK+ + R+ +E ++++
Sbjct: 918 KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976
Query: 2545 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
++E + L+ + + Q Q+E +R+ + + Q E + G+ + +L+
Sbjct: 977 AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036
Query: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2661
QQ R ++ +++ + L+++L LE++ + E+V +V K N
Sbjct: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091
Query: 2662 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2719
A + E D RRK + + + +A I E + V E+ + E L
Sbjct: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149
Query: 2720 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2770
Q S + LL E+ + A L R+L + ++E Q F +DP
Sbjct: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205
Query: 2771 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2806
+ +T +A + + G P+L ++L A++ YK+
Sbjct: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263
Query: 2807 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2865
P ++I +A Q +V HG R E I G D R V+ + E
Sbjct: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321
Query: 2866 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2923
+ VL ++ + E + E V + ++ LL K E+V
Sbjct: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377
Query: 2924 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2981
T + + E + +S + G+ + + E++ LL ++ R+ ++ VE+
Sbjct: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
Query: 2982 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 3036
++ + ++E E++ E +++ V+ E L++ ++R +
Sbjct: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488
Query: 3037 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3096
+V + R + V V + Q+ +IY K+++ L + +A +++
Sbjct: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544
Query: 3097 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3148
+AR +E R A +G + + ++A RD + L Q L+
Sbjct: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600
Query: 3149 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3208
+ R++ + L Q + + ++S R A RG +E SR
Sbjct: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641
Query: 3209 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3268
E A E Q ++ L + A+ +EEL E Q RET T + +
Sbjct: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688
Query: 3269 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3305
P +K G+ + + WE +++ E+ +L ++GK
Sbjct: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746
Query: 3306 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3360
++E ++ EE + L S V P+S L ++S++
Sbjct: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806
Query: 3361 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3419
T+ S LG L S +AGIY T K SI A+ + +L T LLEAQ
Sbjct: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862
Query: 3420 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3479
AATG +VD + +R VH+A++ G++ ++LL+A+KA TG DP + +S+ +A+Q
Sbjct: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922
Query: 3480 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3539
KG + R+ + L+ Q TGG+IDP + R+P+ A G SEE+ ++L D S K
Sbjct: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982
Query: 3540 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3569
DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
Score = 132 bits (331), Expect = 1e-29
Identities = 68/186 (36%), Positives = 116/186 (62%)
Query: 3962 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 4021
IAG++ T + S+ A+ K ++ P T +LLEAQAATG ++D + + +V +A+ G
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
Query: 4022 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4081
++ +LL+A++A TG +DP + K +S+ +A++KG + ++ + L+ Q TGG+ID
Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
Query: 4082 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4141
P+ + R+P++ A G+ EE+ ++L D S K DP ++E L+Y + M RC DP +
Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
Query: 4142 GLCLLP 4147
GL LLP
Sbjct: 2007 GLLLLP 2012
Score = 127 bits (320), Expect = 2e-28
Identities = 73/193 (37%), Positives = 111/193 (57%)
Query: 3053 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3112
IAG++ K SI A+ K++L LLEAQA TG I+D + R +V +A+ G
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
Query: 3113 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3172
L+ ++LL+A+KA TG DP T + +S+ +A++KG +PRE L L Q TGG++D
Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
Query: 3173 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3232
P ++ R+P+ A G + EE ++ L + K +DP + E +Y E RCR D L+
Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
Query: 3233 GLSLLPLSEKAAR 3245
GL LLP + + R
Sbjct: 2007 GLLLLPAALEGYR 2019
Score = 121 bits (304), Expect = 1e-26
Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)
Query: 3719 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3778
+AG+Y + SI A+ K +L + LLEAQAATG ++D + ER +V +A+ +G
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886
Query: 3779 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3838
L+ RLL+A++A TG DP T++ +S+ +A++K +P E L L Q TGG++D
Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946
Query: 3839 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3897
P+ +P++ A G ++++ L E S + DP + ERLSY + + RCR+D +
Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006
Query: 3898 GQLLLP 3903
G LLLP
Sbjct: 2007 GLLLLP 2012
Score = 52.8 bits (125), Expect = 8e-06
Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)
Query: 3008 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3062
+ +LLE++ + L R SV R + E + +R L G+
Sbjct: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
Query: 3063 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3122
++LS+ A++K +P + + L+ Q TG +IDP + R+ + +A+ +G++ E + L
Sbjct: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
Query: 3123 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3165
DP + + +S +A+ + GL LL A L
Sbjct: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
Score = 52.4 bits (124), Expect = 1e-05
Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)
Query: 3674 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3728
+T + L EA+ + +LL S+ +A+E S L + G+ P ++
Sbjct: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912
Query: 3729 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3788
+ LS+ +A++KG + E L+ Q TG L+DP + R+ + +A+ G++ EL L
Sbjct: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972
Query: 3789 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3831
DP +++ +S +AM + L LL A L
Sbjct: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
Score = 47.4 bits (111), Expect = 3e-04
Identities = 32/110 (29%), Positives = 51/110 (46%)
Query: 4025 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4084
P F L + G D + S+ A+ K ++ G +LLEAQ ATGGI+D
Sbjct: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873
Query: 4085 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4134
R V A +RGL + + L + G DP T++ L+ + +++
Sbjct: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
[Homo sapiens]
Length = 2564
Score = 306 bits (784), Expect = 3e-82
Identities = 243/806 (30%), Positives = 379/806 (47%), Gaps = 79/806 (9%)
Query: 63 IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGR 121
+ADER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GR
Sbjct: 55 LADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGR 114
Query: 122 MRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQ 181
MR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ +
Sbjct: 115 MRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETE 174
Query: 182 S--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYR 239
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ +
Sbjct: 175 DNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTK 234
Query: 240 QTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DG 298
NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G
Sbjct: 235 SNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEG 294
Query: 299 VRAN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKF 351
R E+ + Y EL LL W+ ++F +S ++ F +
Sbjct: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
Query: 352 KEMELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILERE 408
+E P K +K + + S++ ++A +L VP G D++K WG+L A ERE
Sbjct: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
Query: 409 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEV 465
LR+E R E L+ + + + + E LN+ L+ D L A ++ +
Sbjct: 415 AALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAI 474
Query: 466 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 525
E D+ + ++ + Q L + Y + R+ + ++ ++ L L V A
Sbjct: 475 EADIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGA 526
Query: 526 PATQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 584
T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L
Sbjct: 527 RRTRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQK 576
Query: 585 HRGLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKL 631
H L I ++E + + Q+ CL L Q A+
Sbjct: 577 HGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR- 635
Query: 632 LNSSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTN 677
+A L + SL + + + W +KE G + +
Sbjct: 636 ---RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLS 692
Query: 678 MTAK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQ 728
TA+ + L EL + +++ G+ L+ P ++ A+ +
Sbjct: 693 STARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASAR 752
Query: 729 TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLE 788
+W + + E L+E A QF +D+ +G L L++A R + D
Sbjct: 753 RRWQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSR 809
Query: 789 DLLQDAQDEKEQLNEYKGHLSGLAKR 814
L + + ++ ++G +SGL ++
Sbjct: 810 RLARQHRALTGEVEAHRGPVSGLRRQ 835
Score = 122 bits (306), Expect = 8e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 1130 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1189
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
Query: 1190 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1238
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
Query: 1239 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1296
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
Query: 1297 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1344
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
Query: 1345 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1401
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
Query: 1402 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1458
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
Query: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
Query: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1578
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
Query: 1579 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
Query: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
Query: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
Query: 1758 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1805
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
Query: 1806 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1862
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
Query: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1921
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
Query: 1922 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
Query: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
E EL R + LAA E + ++ R + E+ R E
Sbjct: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
Query: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
Query: 2101 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2149
S + R + A + R + ++ AA R V E L Q +
Sbjct: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
Query: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2205
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
Query: 2206 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Query: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
Query: 2321 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
Query: 2380 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2436
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
Query: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
Query: 2497 QL 2498
+
Sbjct: 2325 DI 2326
Score = 122 bits (305), Expect = 1e-26
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 1043 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1091
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
Query: 1092 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1151
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
Query: 1152 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1199
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
Query: 1200 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1259
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
Query: 1260 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1319
D + R RQ +AL E+E H V +R Q
Sbjct: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
Query: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1375
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
Query: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
Query: 1436 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1484
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
Query: 1485 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
Query: 1545 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1583
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
Query: 1584 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1641
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
Query: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1700
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
Query: 1701 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
Query: 1761 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1814
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
Query: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1874
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
Query: 1875 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
Query: 1934 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1985
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
Query: 1986 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
Query: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2102
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
Query: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2161
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
Query: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2214
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
Query: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2266
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
Query: 2267 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
Query: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
Query: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2434
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
Query: 2435 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2477
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
Query: 2478 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2533
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
Query: 2534 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
Query: 2592 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2648
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
Query: 2649 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687
A P DA + PA A E R+ SA R +E
Sbjct: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
Score = 102 bits (255), Expect = 7e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
Query: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
Query: 1271 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1319
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
Query: 1320 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1361
L+ A+ + S S +++QE + + + L T+
Sbjct: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
Query: 1362 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1410
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
Query: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1467
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
Query: 1468 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1517
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
Query: 1518 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1570
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
Query: 1571 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1624
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
Query: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1682
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
Query: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
Query: 1743 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1796
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
Query: 1797 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1824
+ + E ++++ +A R +
Sbjct: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
Query: 1825 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1878
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
Query: 1879 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1926
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
Query: 1927 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
Query: 1979 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 2032
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
Query: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2092
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
Query: 2093 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
Query: 2153 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
Query: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
Query: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
Query: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2381
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
Query: 2382 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2427
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
Query: 2428 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
Query: 2484 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
Query: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590
I + ++ +V+ + L Q + ++E L E R
Sbjct: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
Query: 2591 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Query: 2651 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2686
+ L + D ++ A A E F LRR + ++++
Sbjct: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
Score = 99.8 bits (247), Expect = 6e-20
Identities = 341/1654 (20%), Positives = 617/1654 (37%), Gaps = 263/1654 (15%)
Query: 552 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 611
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
Query: 612 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 663
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
Query: 664 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 723
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
Query: 724 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 782
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Query: 783 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 816
++ LE LQ + + L E L+ LA A+
Sbjct: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
Query: 817 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 846
A + ++ + A G LP LLA + E
Sbjct: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
Query: 847 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 906
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
Query: 907 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 952
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
Query: 953 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 1012
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
Query: 1013 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1062
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
Query: 1063 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
Query: 1122 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
Query: 1176 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1235
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
Query: 1236 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1295
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
Query: 1296 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1354
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
Query: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1413
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
Query: 1414 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1467
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
Query: 1468 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1526
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
Query: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1585
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
Query: 1586 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
Query: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1695
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
Query: 1696 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1753
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
Query: 1754 QQRQLLEE--ELARLQREAAAA----TQKRQELEA-ELAKVRAEMEVLLA-----SKARA 1801
+ + L++ E+ + +EA A T + L++ EL E+E L+ KA A
Sbjct: 2039 RHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAA 2098
Query: 1802 EEESRSTS------------EKSKQRLEAEAGRF-----RELAEEAARL-------RALA 1837
E R +S E+SKQ GR ELA +AA L R L
Sbjct: 2099 AWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLE 2158
Query: 1838 EEAKRQRQLAEEDA------ARQRAEAERVLAEKLAAIGEAT-RLKTEAEIALKEKEAEN 1890
A+R + RQ + ER L ++ + E R++ A A E AE
Sbjct: 2159 PLARRASDTLSAEVRTRVGYVRQELKPER-LQPRIDRLPEIPGRVEPAALPAAPEDAAET 2217
Query: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
AE + R Q AD E L + R+ E Q E+ R+RR
Sbjct: 2218 PATPAAAEQVRPRPER------QESADRAEELPRRRRPERQESVDQS---EEAARRRRPE 2268
Query: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010
+E +A +A L LGR ++E R+R+ RR
Sbjct: 2269 RQE----------SAEHEAAHSLTLGRYE-------------QMERRRERR------ERR 2299
Query: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
E +E ++ + + + + + VE+L+ K
Sbjct: 2300 LERQESSEQEMPIRGDLVKGKATLADIVEQLQEK 2333
Score = 85.5 bits (210), Expect = 1e-15
Identities = 275/1239 (22%), Positives = 471/1239 (38%), Gaps = 168/1239 (13%)
Query: 1050 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE----PSPAAPTLRSELELTLGKLEQVR 1105
+A + EV+ + AR+ A +E +LA P A LEL KL +
Sbjct: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLW 1188
Query: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1165
L + L +R + A VLR E L A+ +P T+ +E +
Sbjct: 1189 EARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAE-LPGTVESVEEALKQHRDFLTT 1247
Query: 1166 AEAQQPTFDALRDELRG-----------AQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
E Q G AQE RL +++ E + ++W +++ LE
Sbjct: 1248 MELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLEL 1307
Query: 1215 ------------W---QAVLAQTDVRQRELEQLGRQLRYYRESADPLG--AWLQDARRRQ 1257
W + ++A+ R+ + R LR+ A+ WL+ R
Sbjct: 1308 QHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREG 1367
Query: 1258 EQIQAMPLADSQAVREQLRQEQALLEEIER----HGEKVEECQRFAKQYINAIKDYELQL 1313
+Q+ + +VR++L + + E+E ++ E + A Q + + + + +L
Sbjct: 1368 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK-ADQLVQSFAELDKKL 1426
Query: 1314 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1373
+ ++QL+ V V S + + + Y E+ L +Q E +
Sbjct: 1427 LHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK--- 1483
Query: 1374 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVR 1430
E + E+Q A ERL + L+++R+L A + A EL Q+R+ +
Sbjct: 1484 -ELVGERQNAVG-ERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT 1541
Query: 1431 REEAAVDAQQQ--------KRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1479
+ A QQ +R IQ L+++ + + A ++ +AEA R +++
Sbjct: 1542 ERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS 1601
Query: 1480 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1539
+R EA ER++ + Q + + AE + ++E + + Q Q
Sbjct: 1602 AWAGLR---EAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 1658
Query: 1540 A---EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1596
++L V+ E+ + R +AL E+ E R RQ++V+R + VAL+
Sbjct: 1659 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISR-RQSQVDR---LYVALKE 1714
Query: 1597 A--QRSAEAELQSKRASFAEKTAQLERSLQEEHVA------------VAQLREEAERRAQ 1642
+R E Q + + ++LE + E+ V V+ L+E+ A
Sbjct: 1715 LGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS 1774
Query: 1643 QQAEAERAREEAEREL---------------ERWQLKANEA---------LRLRLQAEEV 1678
+ A R R A ++ W+ NEA R +L A
Sbjct: 1775 ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASR 1834
Query: 1679 AQQKSLAQA-EAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQ-RQL 1727
K + A E + Q EE R E R + ++ +R E Q L Q RQL
Sbjct: 1835 ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQL 1894
Query: 1728 AEGTAQQRLAAEQELIRLRAETEQGEQQ--RQLLEE-ELARLQREAAAATQKRQELEAEL 1784
EG AQ R E A EQ Q ++LL E ARL ++T +++
Sbjct: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLH---VSSTADALRFHSQV 1951
Query: 1785 AKVRAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFRELAEEAARLRA 1835
+ + M+ + AS+ A ++ R S K LEA +E R
Sbjct: 1952 RDLLSWMDGI-ASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTT-CQELGRSLL 2009
Query: 1836 LAEEAKRQRQLAEEDAARQRAEAERVLAEK-------LAAIGEATRLKTEAEIALKEKEA 1888
L + A A+ D R E ++EK L + E + EA +A A
Sbjct: 2010 LNKSAMADEIQAQLDKLGTRKEE---VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTA 2066
Query: 1889 ENERL--RRLAE--DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE---LERQKGLVE 1941
+ L R L DE Q R E + A EER + LR+ + E E+ K
Sbjct: 2067 QEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPT 2126
Query: 1942 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2001
L ++ + LA KA+ G E L + A DTL ++ + + RQ +
Sbjct: 2127 PLLGRKFFGDPTELAAKAAPLLRPGG---YERGLEPLARRASDTLSAEVRTRVGYVRQ-E 2182
Query: 2002 LAAEEERRR----REAEERVQKSL--AAEEEAARQ--RKAALEEVERLKAKVEEARRLRE 2053
L E + R E RV+ + AA E+AA AA E+V + E A +
Sbjct: 2183 LKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESA----D 2238
Query: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113
RAE+ R+ QE+ + +A + + E E +L + + R E
Sbjct: 2239 RAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRER 2298
Query: 2114 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
R +E+ E + + + + + A+ ++Q E++A
Sbjct: 2299 RLERQESSEQEMPIRGDLVKGKATL--ADIVEQLQEKEA 2335
Score = 81.6 bits (200), Expect = 2e-14
Identities = 245/1111 (22%), Positives = 423/1111 (38%), Gaps = 161/1111 (14%)
Query: 890 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLK--PE 947
++AQEAVTRL ++Q Q + L Q RD + W +
Sbjct: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333
Query: 948 EQRQALHSLELHYQAFL--------------RDSQDAGGFGPEDRLMAEREYGSCSHHYQ 993
E LH L +QAF+ R+ Q PE ++ G +
Sbjct: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG----EIR 1389
Query: 994 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRI 1050
Q LE Q ++R S+ + + + +H D +P + A ++
Sbjct: 1390 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 1449
Query: 1051 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1110
+ Q +++VE + V L A+ ALP PA+ L E + +G+ VR
Sbjct: 1450 KKLQSMESQVEEWYREVGELQAQ---TAALP-LEPASKELVGERQNAVGE-RLVR----- 1499
Query: 1111 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ-AVPATLPE-----LEATKASLKK--- 1161
LE L+ ++ ++ +V +++L Q +P + L+A + +KK
Sbjct: 1500 LLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQG 1559
Query: 1162 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1221
LR + +A P +EV ER R E E R + QL W +
Sbjct: 1560 LRREIQAHGPRL----------EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREA 1609
Query: 1222 TDVRQRELEQLGRQLRYYRESADPLGAWL--------QDARRRQEQIQAMPLAD------ 1267
+ RQ+ L+ + +YY + A+ + AWL + + + EQ L
Sbjct: 1610 AERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 1668
Query: 1268 -----SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY-ELQLVTYKAQ-- 1319
+++ + RQ +ALLE E++ Q + A+K+ E + V + Q
Sbjct: 1669 GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYW 1728
Query: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379
L ++ + + + V+ +L + ++ L ++ +F SET M ERLA
Sbjct: 1729 LYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET--GMAGRERLAA 1786
Query: 1380 -QQRAEERERLAEVEAA--LEKQRQLAEAHAQ------AKAQ---AERE-------AKEL 1420
Q +E AA E + L EA A+ +AQ A RE A+EL
Sbjct: 1787 VNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAREL 1846
Query: 1421 QQRMQEEVVR---------REEAAVDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQA 1467
Q +++E+ R +A Q+ R+ + +LQ Q+RQ E Q + A
Sbjct: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYA 1906
Query: 1468 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526
E AE R +E ++ + L A E R ALR +Q R + +
Sbjct: 1907 GEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR-----FHSQVRDLLSWMDGI 1961
Query: 1527 RRQVQDESQRKRQAEVELASR----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1582
Q+ + + + VE+ +K E EA + Q L L + A QA
Sbjct: 1962 ASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
Query: 1583 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
++++ ++ +E + + ++ ++ + QE VA A L A+
Sbjct: 2022 QLDKL--------GTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWL--TAQEPLL 2071
Query: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1702
Q E + +E E+ + R + A + + + ++ + +AE+ K+ R
Sbjct: 2072 QSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGR 2131
Query: 1703 R--GKAEEQAVRQRELA-----EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1755
+ G E A + L E+ LE + A T + +R + E+ + +
Sbjct: 2132 KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPR 2191
Query: 1756 RQLLEEELARLQREA---------------AAATQKRQELEAELAKVRAEMEVLLASKAR 1800
L E R++ A AAA Q R E + + RAE L + R
Sbjct: 2192 IDRLPEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEE---LPRRRR 2248
Query: 1801 AE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDAARQRAE 1857
E +ES SE++ +R E R EAA L E+ +R+R+ E RQ +
Sbjct: 2249 PERQESVDQSEEAARRRRPE--RQESAEHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
Query: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
+ + G+AT + L+EKEA
Sbjct: 2307 EQEMPIRGDLVKGKATLADIVEQ--LQEKEA 2335
Score = 81.3 bits (199), Expect = 2e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1598
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
Query: 1599 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1631
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
Query: 1632 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Query: 1687 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1743
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
Query: 1744 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1777
LR E GE+++ LL +++ +Q + Q+
Sbjct: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
Query: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1828
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
Query: 1829 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1871
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
Query: 1872 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1912
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
Query: 1913 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1971
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
Query: 1972 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 2014
LELG ++ E + QA L RQ + +
Sbjct: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
Query: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2074
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
Query: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2124
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
Query: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
Query: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2244
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
Query: 2245 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
Query: 2305 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2364
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
Query: 2365 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2405
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
Query: 2406 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2448
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
Query: 2449 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2500
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
Query: 2501 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2535
E + +++++ + L Q F L EK S + RER
Sbjct: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
Query: 2536 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2575
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
Query: 2576 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2632
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
Query: 2633 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2692
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
Query: 2693 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2726
E L QG T V EL +++ R L +S++A
Sbjct: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
Score = 66.6 bits (161), Expect = 5e-10
Identities = 277/1408 (19%), Positives = 520/1408 (36%), Gaps = 194/1408 (13%)
Query: 409 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 468
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
Query: 469 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 527
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
Query: 528 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 580
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
Query: 581 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 636
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
Query: 637 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 694
+L L F+ + W++EK D N + + + A M EL
Sbjct: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
Query: 695 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 754
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
Query: 755 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 814
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
Query: 815 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 873
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
Query: 874 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 931
+ + E RL Q + L + + Q LRR++Q
Sbjct: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
Query: 932 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 978
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
Query: 979 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1038
E + + L+ S ++G E+S Q L LQLE
Sbjct: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
Query: 1039 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1097
VE + +A+LS + +L + P S +S+++
Sbjct: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
Query: 1098 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1157
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
Query: 1158 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
Query: 1217 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1276
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
Query: 1277 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1336
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
Query: 1337 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1395
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
Query: 1396 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
Query: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
Query: 1513 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1572
+E LRR L + K +AE +++ L +
Sbjct: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
Query: 1573 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1623
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
Query: 1624 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1678
E E A+ E+A A AE+ R ER Q A+ A EE+
Sbjct: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESADRA-------EEL 2243
Query: 1679 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1735
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
Query: 1736 LAAEQELIRLRAETEQGEQQRQLLEEEL 1763
++EQE+ +R + +G+ + E+L
Sbjct: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
Score = 60.5 bits (145), Expect = 4e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 320 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 378
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
Query: 379 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 426
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
Query: 427 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 461
+ E G + E+L + LQ RLL A K + Q
Sbjct: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
Query: 462 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 507
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
Query: 508 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 559
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
Query: 560 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 608
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
Query: 609 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 663
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
Query: 664 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 720
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
Query: 721 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 772
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
Query: 773 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 823
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
Query: 824 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 883
G LL+ C+ ++ V+ A H +V + S
Sbjct: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
Query: 884 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 936
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
Query: 937 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 989
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
Query: 990 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1049
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
Query: 1050 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1108
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
Query: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
Query: 1169 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1222
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Query: 1223 DVRQRELEQ 1231
+ R+R LE+
Sbjct: 2294 ERRERRLER 2302
Score = 59.3 bits (142), Expect = 8e-08
Identities = 269/1244 (21%), Positives = 450/1244 (36%), Gaps = 196/1244 (15%)
Query: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
E E A +REAA + ++ + EL R + +V + E + + + L A
Sbjct: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
Query: 1820 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---------LAAIG 1870
++ A + A E + +LA+ AA + RV A++ L +
Sbjct: 465 EAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLV 524
Query: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
A R + E +AL++ E + + E Q + L + QH + ++ L Q +
Sbjct: 525 GARRTRLEQNLALQK--VFQEMVYMVDWMEEMQAQLLSRECGQHLVEADD-LLQKHGLLE 581
Query: 1931 SELERQKGLVE---------DTLRQRRQVEEEILALKASF---------EKAAAGKAELE 1972
++ Q VE L+ + + +++ + + E+AA +AELE
Sbjct: 582 GDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELE 641
Query: 1973 LE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2027
L + AE R KE+ LEAA A L++
Sbjct: 642 ASRSLWALLQELEEAESWARDKERL-LEAAGGGGAAGAAGAAGTAGGAH---DLSSTARL 697
Query: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQ---------ESARQLQLAQEAAQKRLQAEE 2078
Q K E+ +A +++A R E ++ + LA+ AA R + +
Sbjct: 698 LAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQR 757
Query: 2079 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRR 2136
A A +++ + + L Q + LD L A R A + +A R A Q R
Sbjct: 758 LEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRA 817
Query: 2137 QVEEAER--------LKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQAEQAALRQK 2187
E E +Q A + A A ++R EAEQ A E AALR++
Sbjct: 818 LTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAE--VTEVAALRRQ 875
Query: 2188 QAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRL-----QLEETDHQKNLLDEELQRLK 2240
DA + ++ F E + + EQ L ++R+ +E H+ LD+E+ L
Sbjct: 876 WLRDA-LAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLM 934
Query: 2241 AEA-----------------------------------TEAARQRSQVEEELFSVRVQME 2265
E QR + + V +
Sbjct: 935 GRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVL 994
Query: 2266 ELSKLKARIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQ 2315
E+++++A++ + RA+ + + LQ + + EEAA L+
Sbjct: 995 EVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPA 1054
Query: 2316 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2375
+AARL Q AEE A+ ALA A Q A A LQ R
Sbjct: 1055 QAARLHQGAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLH 1095
Query: 2376 DKEQMAQQL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2433
D + L A+E G E LE EA+ L R A + + EED R
Sbjct: 1096 DLDAFLDWLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARI 1149
Query: 2434 RKQAE--------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLR 2476
+E E+G E L EL + + L + +Q LR
Sbjct: 1150 VAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLR 1209
Query: 2477 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQR 2532
+A+ L ++ L ++S E Q L Q +Q + + + L Q
Sbjct: 1210 QALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQG 1269
Query: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE---- 2588
+ EQ + + +L + + QLR +Q Q+ + E Q + E HE
Sbjct: 1270 NIYGEQAQEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLM 1327
Query: 2589 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648
A +G R E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS
Sbjct: 1328 ARDGTR---EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRK 1383
Query: 2649 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTT 2705
+ L+ +A+ F+ + Q E +L E +LQ + G
Sbjct: 1384 KLGEIRQCWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG--- 1439
Query: 2706 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG- 2764
+LA LQ S + E + AAL L P + ++ E Q A G
Sbjct: 1440 -GDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGE 1495
Query: 2765 ---FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---A 2818
LL+P++ RR + + + V +L +L + + G + Q
Sbjct: 1496 RLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIK 1555
Query: 2819 MQKGL--IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2860
+GL ++ HG RL E G + S R P A RRG
Sbjct: 1556 KNQGLRREIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
Score = 35.8 bits (81), Expect = 1.0
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 268 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 324
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
Query: 325 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 384
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
Query: 385 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 443
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
Query: 444 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 503
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
Query: 504 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 559
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
Query: 560 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 612
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
Query: 613 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 663
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 154,360,720
Number of Sequences: 37866
Number of extensions: 7120329
Number of successful extensions: 173478
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1093
Number of HSP's successfully gapped in prelim test: 1681
Number of HSP's that attempted gapping in prelim test: 29549
Number of HSP's gapped (non-prelim): 40844
length of query: 4574
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4451
effective length of database: 13,590,000
effective search space: 60489090000
effective search space used: 60489090000
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.