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Search of human proteins with 4758476
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
(330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 692 0.0
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 170 2e-42
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 164 1e-40
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 120 2e-27
gi|193220941 hypothetical protein LOC400581 [Homo sapiens] 95 1e-19
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 90 2e-18
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 90 3e-18
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 90 3e-18
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 88 1e-17
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 88 1e-17
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 88 1e-17
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 87 2e-17
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 87 2e-17
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 87 2e-17
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 87 2e-17
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 87 2e-17
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 84 2e-16
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 84 2e-16
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 84 2e-16
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 84 2e-16
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 84 2e-16
gi|4503787 fyn-related kinase [Homo sapiens] 83 3e-16
gi|187475373 c-src tyrosine kinase [Homo sapiens] 81 1e-15
gi|4758078 c-src tyrosine kinase [Homo sapiens] 81 1e-15
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 80 2e-15
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 78 1e-14
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 77 3e-14
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 77 3e-14
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 77 3e-14
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 77 3e-14
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 692 bits (1785), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFH 60
MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFH
Sbjct: 1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFH 60
Query: 61 EGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTE 120
EGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTE
Sbjct: 61 EGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTE 120
Query: 121 KFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRP 180
KFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRP
Sbjct: 121 KFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRP 180
Query: 181 SMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDIN 240
SMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDIN
Sbjct: 181 SMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDIN 240
Query: 241 DGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEV 300
DGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEV
Sbjct: 241 DGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEV 300
Query: 301 LDSSNPSWWTGRLHNKLGLFPANYVAPMTR 330
LDSSNPSWWTGRLHNKLGLFPANYVAPMTR
Sbjct: 301 LDSSNPSWWTGRLHNKLGLFPANYVAPMTR 330
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 170 bits (430), Expect = 2e-42
Identities = 80/150 (53%), Positives = 114/150 (76%), Gaps = 3/150 (2%)
Query: 1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQ--EEWFKAELGSQEGYVPKNFIDIQFPKW 58
MEA+AK+DF A+ +DELSF GD+LK+L+ + + W+KAEL ++G++PKN+I+++ W
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 60
Query: 59 FHEGLSRHQAENLLMG-KEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
F + R +AE +L + G F+IR S+S+PGDFS+SV+ +DVQHFKV+RD G YFL
Sbjct: 61 FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL 120
Query: 118 WTEKFPSLNKLVDYYRTNSISRQKQIFLRD 147
W KF SLN+LVDY+R+ S+SR +QIFLRD
Sbjct: 121 WVVKFNSLNELVDYHRSTSVSRNQQIFLRD 150
Score = 71.6 bits (174), Expect = 9e-13
Identities = 27/56 (48%), Positives = 40/56 (71%)
Query: 275 WARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR 330
+ +AL+DF+ ED ELGF G+ + V+D+S+P+WW G H + G+FP NYV P+ R
Sbjct: 160 YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNR 215
Score = 45.8 bits (107), Expect = 5e-05
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 276 ARALYDFEALEDDELGFHSGEVVEVL-DSSNPSWWTGRLHNKLGLFPANYV 325
A A YDF+A DDEL F G++++VL + + +W+ L+ K G P NY+
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
Score = 37.7 bits (86), Expect = 0.014
Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 1/48 (2%)
Query: 5 AKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGSQEGYVPKNFI 51
A FDF + EL F GD + ++ N + W+K Q G P+N++
Sbjct: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 210
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 164 bits (415), Expect = 1e-40
Identities = 79/150 (52%), Positives = 113/150 (75%), Gaps = 3/150 (2%)
Query: 1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQEE--WFKAELGSQEGYVPKNFIDIQFPKW 58
ME+VA + F A+ DEL+F+ GD LKIL+ +++ W+KAEL EG++PKN+I ++ W
Sbjct: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
Query: 59 FHEGLSRHQAENLLMGKE-VGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
+ +SR AE +LM + +G F+IR S+SSPG+FS+SV + D VQHFKV+R+ G YFL
Sbjct: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFL 120
Query: 118 WTEKFPSLNKLVDYYRTNSISRQKQIFLRD 147
W EKF SLN+LVD+YRT +I++++QIFLRD
Sbjct: 121 WEEKFNSLNELVDFYRTTTIAKKRQIFLRD 150
Score = 57.8 bits (138), Expect = 1e-08
Identities = 22/54 (40%), Positives = 36/54 (66%)
Query: 275 WARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPM 328
+A+A +DF A + +L F G+++EVL+ +P WW GR ++G FP +YV P+
Sbjct: 162 FAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPV 215
Score = 42.7 bits (99), Expect = 4e-04
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYV 325
ALY F+A E DEL F+ G+ +++L+ + +W+ L G P NY+
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
Score = 38.9 bits (89), Expect = 0.006
Identities = 15/50 (30%), Positives = 31/50 (62%), Gaps = 1/50 (2%)
Query: 3 AVAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGSQEGYVPKNFI 51
A A+FDF+A +LSF GD++++L + W++ + G+ P++++
Sbjct: 163 AQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYV 212
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 120 bits (300), Expect = 2e-27
Identities = 63/149 (42%), Positives = 88/149 (59%), Gaps = 42/149 (28%)
Query: 1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQ--EEWFKAELGSQEGYVPKNFIDIQFPKW 58
MEA+AK+DF A+ +DELSF GD+LK+L+ + + W+KAEL ++G++PKN+I+++
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMK---- 56
Query: 59 FHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLW 118
P F +DVQHFKV+RD G YFLW
Sbjct: 57 ------------------------------PHPFG------NDVQHFKVLRDGAGKYFLW 80
Query: 119 TEKFPSLNKLVDYYRTNSISRQKQIFLRD 147
KF SLN+LVDY+R+ S+SR +QIFLRD
Sbjct: 81 VVKFNSLNELVDYHRSTSVSRNQQIFLRD 109
Score = 71.6 bits (174), Expect = 9e-13
Identities = 27/56 (48%), Positives = 40/56 (71%)
Query: 275 WARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR 330
+ +AL+DF+ ED ELGF G+ + V+D+S+P+WW G H + G+FP NYV P+ R
Sbjct: 119 YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNR 174
Score = 45.8 bits (107), Expect = 5e-05
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 276 ARALYDFEALEDDELGFHSGEVVEVL-DSSNPSWWTGRLHNKLGLFPANYV 325
A A YDF+A DDEL F G++++VL + + +W+ L+ K G P NY+
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
Score = 37.7 bits (86), Expect = 0.014
Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 1/48 (2%)
Query: 5 AKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGSQEGYVPKNFI 51
A FDF + EL F GD + ++ N + W+K Q G P+N++
Sbjct: 122 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 169
>gi|193220941 hypothetical protein LOC400581 [Homo sapiens]
Length = 118
Score = 94.7 bits (234), Expect = 1e-19
Identities = 47/101 (46%), Positives = 72/101 (71%), Gaps = 3/101 (2%)
Query: 1 MEAVAKFDFTASGEDELSFHTGDVLKILSNQEE--WFKAELGSQEGYVPKNFIDIQFPKW 58
ME+VA + F A+ DEL+F+ GD LKIL+ +++ W+KAEL EG++PKN+I ++ W
Sbjct: 1 MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPW 60
Query: 59 FHEGLSRHQAENLLMGK-EVGFFIIRASQSSPGDFSISVRH 98
+ +SR AE +LM + +G F+IR S+SSPG+FS+SV +
Sbjct: 61 YSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNN 101
Score = 42.7 bits (99), Expect = 4e-04
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYV 325
ALY F+A E DEL F+ G+ +++L+ + +W+ L G P NY+
Sbjct: 5 ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 90.1 bits (222), Expect = 2e-18
Identities = 52/144 (36%), Positives = 83/144 (57%), Gaps = 14/144 (9%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAE--LGSQEGYVPKNFI----DIQFPK 57
VA +D+ A ++LSF GD + +L EW+KA +EGY+P N++ ++ +
Sbjct: 84 VALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEE 143
Query: 58 WFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISV-----RHEDDVQHFKVMR- 109
WF +G+SR AE L+ G +G F+IR S+++ G +S+SV R D V+H+K+
Sbjct: 144 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 203
Query: 110 DNKGNYFLWTEKFPSLNKLVDYYR 133
DN G Y F +L +LVD+Y+
Sbjct: 204 DNGGFYISPRSTFSTLQELVDHYK 227
Score = 43.5 bits (101), Expect = 3e-04
Identities = 22/51 (43%), Positives = 30/51 (58%), Gaps = 3/51 (5%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVA 326
ALYD+EA+ ++L F G+ + VL+ S WW R K G P+NYVA
Sbjct: 85 ALYDYEAIHHEDLSFQKGDQMVVLEESG-EWWKARSLATRKEGYIPSNYVA 134
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 89.7 bits (221), Expect = 3e-18
Identities = 50/138 (36%), Positives = 86/138 (62%), Gaps = 7/138 (5%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKIL--SNQEEWFKAELGSQEGYVPKNFI----DIQFPK 57
VA +DF ASG++ LS G+ L++L ++ EW +A+ + +G+VP N+I ++
Sbjct: 67 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS 126
Query: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
W+H +SR+ AE LL G F++R S+SSPG SIS+R+E V H+++ + G ++
Sbjct: 127 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 186
Query: 118 WTE-KFPSLNKLVDYYRT 134
+E +F +L +LV ++ T
Sbjct: 187 SSESRFNTLAELVHHHST 204
Score = 37.7 bits (86), Expect = 0.014
Identities = 20/52 (38%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYVAPM 328
ALYDF A D+ L GE + VL + N W + N G P+NY+ P+
Sbjct: 68 ALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV 119
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 89.7 bits (221), Expect = 3e-18
Identities = 50/138 (36%), Positives = 86/138 (62%), Gaps = 7/138 (5%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKIL--SNQEEWFKAELGSQEGYVPKNFI----DIQFPK 57
VA +DF ASG++ LS G+ L++L ++ EW +A+ + +G+VP N+I ++
Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS 145
Query: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
W+H +SR+ AE LL G F++R S+SSPG SIS+R+E V H+++ + G ++
Sbjct: 146 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 205
Query: 118 WTE-KFPSLNKLVDYYRT 134
+E +F +L +LV ++ T
Sbjct: 206 SSESRFNTLAELVHHHST 223
Score = 37.7 bits (86), Expect = 0.014
Identities = 20/52 (38%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYVAPM 328
ALYDF A D+ L GE + VL + N W + N G P+NY+ P+
Sbjct: 87 ALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPV 138
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 87.8 bits (216), Expect = 1e-17
Identities = 51/144 (35%), Positives = 86/144 (59%), Gaps = 15/144 (10%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAE--LGSQEGYVPKNFI----DIQFP 56
VA +D+ A ED+LSFH G+ +IL++ E +W++A + GY+P N++ IQ
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 57 KWFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHEDD-----VQHFKVMR 109
+W+ L R AE L+ G G F+IR S+++ G +S+S+R DD V+H+K+ +
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 110 DNKGNYFLWTE-KFPSLNKLVDYY 132
+ G Y++ T +F +L +LV +Y
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHY 231
Score = 62.4 bits (150), Expect = 5e-10
Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 240 NDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVE 299
N+ H G G + + HT ++ + V ALYD+EA +D+L FH GE +
Sbjct: 51 NNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQ 110
Query: 300 VLDSSNPSWWTGR--LHNKLGLFPANYVAPM 328
+L+SS WW R + G P+NYVAP+
Sbjct: 111 ILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 87.8 bits (216), Expect = 1e-17
Identities = 51/144 (35%), Positives = 86/144 (59%), Gaps = 15/144 (10%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAE--LGSQEGYVPKNFI----DIQFP 56
VA +D+ A ED+LSFH G+ +IL++ E +W++A + GY+P N++ IQ
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 57 KWFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHEDD-----VQHFKVMR 109
+W+ L R AE L+ G G F+IR S+++ G +S+S+R DD V+H+K+ +
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 110 DNKGNYFLWTE-KFPSLNKLVDYY 132
+ G Y++ T +F +L +LV +Y
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHY 231
Score = 62.4 bits (150), Expect = 5e-10
Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 240 NDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVE 299
N+ H G G + + HT ++ + V ALYD+EA +D+L FH GE +
Sbjct: 51 NNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQ 110
Query: 300 VLDSSNPSWWTGR--LHNKLGLFPANYVAPM 328
+L+SS WW R + G P+NYVAP+
Sbjct: 111 ILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 87.8 bits (216), Expect = 1e-17
Identities = 51/144 (35%), Positives = 86/144 (59%), Gaps = 15/144 (10%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAE--LGSQEGYVPKNFI----DIQFP 56
VA +D+ A ED+LSFH G+ +IL++ E +W++A + GY+P N++ IQ
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147
Query: 57 KWFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHEDD-----VQHFKVMR 109
+W+ L R AE L+ G G F+IR S+++ G +S+S+R DD V+H+K+ +
Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207
Query: 110 DNKGNYFLWTE-KFPSLNKLVDYY 132
+ G Y++ T +F +L +LV +Y
Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHY 231
Score = 62.4 bits (150), Expect = 5e-10
Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 2/91 (2%)
Query: 240 NDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVE 299
N+ H G G + + HT ++ + V ALYD+EA +D+L FH GE +
Sbjct: 51 NNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQ 110
Query: 300 VLDSSNPSWWTGR--LHNKLGLFPANYVAPM 328
+L+SS WW R + G P+NYVAP+
Sbjct: 111 ILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 87.0 bits (214), Expect = 2e-17
Identities = 49/138 (35%), Positives = 80/138 (57%), Gaps = 7/138 (5%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE--EWFKAELGSQEGYVPKNFI----DIQFPK 57
VA +DF ASG++ LS G+ L++L + EW + + +G+VP N+I ++
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
Query: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
W+H +SR AE LL G F++R S+SSPG SIS+R+E V H+++ G ++
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217
Query: 118 WTE-KFPSLNKLVDYYRT 134
E +F +L +LV ++ T
Sbjct: 218 TAESRFSTLAELVHHHST 235
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/108 (31%), Positives = 45/108 (41%), Gaps = 19/108 (17%)
Query: 239 INDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGR-VRWAR----------------ALYD 281
+ DG G G AL HR + V+ QA +RW+ ALYD
Sbjct: 44 VEDGFEGDKTGGSSPEAL-HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYD 102
Query: 282 FEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYVAPM 328
F A D+ L GE + VL + N W R N G P+NY+ P+
Sbjct: 103 FVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPV 150
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 87.0 bits (214), Expect = 2e-17
Identities = 49/138 (35%), Positives = 80/138 (57%), Gaps = 7/138 (5%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE--EWFKAELGSQEGYVPKNFI----DIQFPK 57
VA +DF ASG++ LS G+ L++L + EW + + +G+VP N+I ++
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 172
Query: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
W+H +SR AE LL G F++R S+SSPG SIS+R+E V H+++ G ++
Sbjct: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232
Query: 118 WTE-KFPSLNKLVDYYRT 134
E +F +L +LV ++ T
Sbjct: 233 TAESRFSTLAELVHHHST 250
Score = 43.5 bits (101), Expect = 3e-04
Identities = 46/158 (29%), Positives = 61/158 (38%), Gaps = 38/158 (24%)
Query: 201 QPQPP----QYAPAPQQLQQPPQQR--------YLQHHHFHQERRGGSLDINDGHCGTGL 248
QPQP A P ++ P R + QH HF + + DG G
Sbjct: 16 QPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHF-------ASCVEDGFEGDKT 68
Query: 249 GSEMNAALMHRRHTDPVQLQAAGR-VRWAR----------------ALYDFEALEDDELG 291
G AL HR + V+ QA +RW+ ALYDF A D+ L
Sbjct: 69 GGSSPEAL-HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLS 127
Query: 292 FHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYVAPM 328
GE + VL + N W R N G P+NY+ P+
Sbjct: 128 ITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPV 165
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 87.0 bits (214), Expect = 2e-17
Identities = 49/138 (35%), Positives = 80/138 (57%), Gaps = 7/138 (5%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE--EWFKAELGSQEGYVPKNFI----DIQFPK 57
VA +DF ASG++ LS G+ L++L + EW + + +G+VP N+I ++
Sbjct: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 151
Query: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
W+H +SR AE LL G F++R S+SSPG SIS+R+E V H+++ G ++
Sbjct: 152 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 211
Query: 118 WTE-KFPSLNKLVDYYRT 134
E +F +L +LV ++ T
Sbjct: 212 TAESRFSTLAELVHHHST 229
Score = 38.1 bits (87), Expect = 0.011
Identities = 30/101 (29%), Positives = 41/101 (40%), Gaps = 18/101 (17%)
Query: 246 TGLGSEMNAALMHRRHTDPVQLQAAGR-VRWAR----------------ALYDFEALEDD 288
TG +HR + V+ QA +RW+ ALYDF A D+
Sbjct: 44 TGFNIFTQHEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDN 103
Query: 289 ELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYVAPM 328
L GE + VL + N W R N G P+NY+ P+
Sbjct: 104 TLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPV 144
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 87.0 bits (214), Expect = 2e-17
Identities = 49/138 (35%), Positives = 80/138 (57%), Gaps = 7/138 (5%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE--EWFKAELGSQEGYVPKNFI----DIQFPK 57
VA +DF ASG++ LS G+ L++L + EW + + +G+VP N+I ++
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 157
Query: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
W+H +SR AE LL G F++R S+SSPG SIS+R+E V H+++ G ++
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217
Query: 118 WTE-KFPSLNKLVDYYRT 134
E +F +L +LV ++ T
Sbjct: 218 TAESRFSTLAELVHHHST 235
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/108 (31%), Positives = 45/108 (41%), Gaps = 19/108 (17%)
Query: 239 INDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGR-VRWAR----------------ALYD 281
+ DG G G AL HR + V+ QA +RW+ ALYD
Sbjct: 44 VEDGFEGDKTGGSSPEAL-HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYD 102
Query: 282 FEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYVAPM 328
F A D+ L GE + VL + N W R N G P+NY+ P+
Sbjct: 103 FVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPV 150
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 87.0 bits (214), Expect = 2e-17
Identities = 49/138 (35%), Positives = 80/138 (57%), Gaps = 7/138 (5%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE--EWFKAELGSQEGYVPKNFI----DIQFPK 57
VA +DF ASG++ LS G+ L++L + EW + + +G+VP N+I ++
Sbjct: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHS 136
Query: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
W+H +SR AE LL G F++R S+SSPG SIS+R+E V H+++ G ++
Sbjct: 137 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 196
Query: 118 WTE-KFPSLNKLVDYYRT 134
E +F +L +LV ++ T
Sbjct: 197 TAESRFSTLAELVHHHST 214
Score = 37.7 bits (86), Expect = 0.014
Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKLGLFPANYVAPM 328
ALYDF A D+ L GE + VL + N W R N G P+NY+ P+
Sbjct: 78 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPV 129
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 84.0 bits (206), Expect = 2e-16
Identities = 54/147 (36%), Positives = 79/147 (53%), Gaps = 14/147 (9%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAE--LGSQEGYVPKNFI----DIQFPK 57
+A + S + +L F G+ L+IL EW+KA+ QEG++P NF+ ++
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP 126
Query: 58 WFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHEDD-----VQHFKVMR- 109
WF + LSR AE L+ G G F+IR S+S+ G FS+SVR D V+H+K+
Sbjct: 127 WFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNL 186
Query: 110 DNKGNYFLWTEKFPSLNKLVDYYRTNS 136
DN G Y FP L++LV +Y S
Sbjct: 187 DNGGFYISPRITFPGLHELVRHYTNAS 213
Score = 35.8 bits (81), Expect = 0.054
Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 3/51 (5%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVA 326
AL+ +E D +LGF GE + +L+ S WW + + G P N+VA
Sbjct: 68 ALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEGFIPFNFVA 117
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 84.0 bits (206), Expect = 2e-16
Identities = 54/147 (36%), Positives = 79/147 (53%), Gaps = 14/147 (9%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAE--LGSQEGYVPKNFI----DIQFPK 57
+A + S + +L F G+ L+IL EW+KA+ QEG++P NF+ ++
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP 126
Query: 58 WFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHEDD-----VQHFKVMR- 109
WF + LSR AE L+ G G F+IR S+S+ G FS+SVR D V+H+K+
Sbjct: 127 WFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNL 186
Query: 110 DNKGNYFLWTEKFPSLNKLVDYYRTNS 136
DN G Y FP L++LV +Y S
Sbjct: 187 DNGGFYISPRITFPGLHELVRHYTNAS 213
Score = 35.8 bits (81), Expect = 0.054
Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 3/51 (5%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVA 326
AL+ +E D +LGF GE + +L+ S WW + + G P N+VA
Sbjct: 68 ALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEGFIPFNFVA 117
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 84.0 bits (206), Expect = 2e-16
Identities = 47/144 (32%), Positives = 81/144 (56%), Gaps = 14/144 (9%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAE--LGSQEGYVPKNFI----DIQFPK 57
VA + + D+LSF G+ +K+L EW+KA+ L +EG++P N++ ++ +
Sbjct: 48 VALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE 107
Query: 58 WFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVR-----HEDDVQHFKVMR- 109
WF + ++R AE L+ G G F+IR S++ G FS+SVR H D ++H+K+
Sbjct: 108 WFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSL 167
Query: 110 DNKGNYFLWTEKFPSLNKLVDYYR 133
DN G Y FP ++ ++ +Y+
Sbjct: 168 DNGGYYISPRITFPCISDMIKHYQ 191
Score = 41.2 bits (95), Expect = 0.001
Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 3/53 (5%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVAPM 328
ALY ++ + D+L F GE ++VL+ + WW + L K G P+NYVA +
Sbjct: 49 ALYPYDGIHPDDLSFKKGEKMKVLE-EHGEWWKAKSLLTKKEGFIPSNYVAKL 100
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 84.0 bits (206), Expect = 2e-16
Identities = 47/144 (32%), Positives = 81/144 (56%), Gaps = 14/144 (9%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAE--LGSQEGYVPKNFI----DIQFPK 57
VA + + D+LSF G+ +K+L EW+KA+ L +EG++P N++ ++ +
Sbjct: 69 VALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE 128
Query: 58 WFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVR-----HEDDVQHFKVMR- 109
WF + ++R AE L+ G G F+IR S++ G FS+SVR H D ++H+K+
Sbjct: 129 WFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSL 188
Query: 110 DNKGNYFLWTEKFPSLNKLVDYYR 133
DN G Y FP ++ ++ +Y+
Sbjct: 189 DNGGYYISPRITFPCISDMIKHYQ 212
Score = 41.2 bits (95), Expect = 0.001
Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 3/53 (5%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVAPM 328
ALY ++ + D+L F GE ++VL+ + WW + L K G P+NYVA +
Sbjct: 70 ALYPYDGIHPDDLSFKKGEKMKVLE-EHGEWWKAKSLLTKKEGFIPSNYVAKL 121
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 84.0 bits (206), Expect = 2e-16
Identities = 47/144 (32%), Positives = 86/144 (59%), Gaps = 15/144 (10%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAE--LGSQEGYVPKNFI----DIQFP 56
VA +D+ A ++LSF G+ +I++N E +W++A + GY+P N++ IQ
Sbjct: 97 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAE 156
Query: 57 KWFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVR-----HEDDVQHFKVMR 109
+W+ + R AE LL+ G + G F++R S+++ G +S+S+R D+V+H+K+ +
Sbjct: 157 EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRK 216
Query: 110 DNKGNYFLWTE-KFPSLNKLVDYY 132
+ G Y++ T +F +L KLV +Y
Sbjct: 217 LDNGGYYITTRAQFDTLQKLVKHY 240
Score = 47.0 bits (110), Expect = 2e-05
Identities = 21/52 (40%), Positives = 31/52 (59%), Gaps = 2/52 (3%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVAP 327
ALYD+EA ++L F GE ++++++ WW R K G P+NYVAP
Sbjct: 98 ALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAP 149
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 83.2 bits (204), Expect = 3e-16
Identities = 51/150 (34%), Positives = 79/150 (52%), Gaps = 17/150 (11%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEE--WFKAELGSQ--------EGYVPKNFI-- 51
VA FD+ A ++LSF GD L++L E WF L + +GY+P N++
Sbjct: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
Query: 52 --DIQFPKWFHEGLSRHQAENLLMGKE--VGFFIIRASQSSPGDFSISVRHEDDVQHFKV 107
+Q WF + R AE L+ E G F+IR S+S G+FS+SV V+H+++
Sbjct: 108 DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRI 167
Query: 108 MRDNKGNYFLWTEK-FPSLNKLVDYYRTNS 136
R ++G +FL + F +LN+ V +Y S
Sbjct: 168 KRLDEGGFFLTRRRIFSTLNEFVSHYTKTS 197
Score = 40.8 bits (94), Expect = 0.002
Identities = 20/58 (34%), Positives = 32/58 (55%), Gaps = 9/58 (15%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNK---------LGLFPANYVA 326
AL+D++A ++L F +G+ ++VLD+ + WW R K G P+NYVA
Sbjct: 49 ALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 80.9 bits (198), Expect = 1e-15
Identities = 45/148 (30%), Positives = 81/148 (54%), Gaps = 13/148 (8%)
Query: 2 EAVAKFDFTASGEDELSFHTGDVLKILSNQEE--WFKAELG-SQEGYVPKNFID------ 52
E +AK++F + E +L F GDVL I++ ++ W+KA+ +EG +P N++
Sbjct: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72
Query: 53 ----IQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVM 108
+ WFH ++R QAE LL E G F++R S + PGD+++ V + V+H+++M
Sbjct: 73 AGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIM 132
Query: 109 RDNKGNYFLWTEKFPSLNKLVDYYRTNS 136
F +L +LV++Y +++
Sbjct: 133 YHASKLSIDEEVYFENLMQLVEHYTSDA 160
Score = 31.6 bits (70), Expect = 1.0
Identities = 17/52 (32%), Positives = 31/52 (59%), Gaps = 6/52 (11%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKL---GLFPANYV 325
A Y+F + +L F G+V+ ++ + +P+W+ + NK+ G+ PANYV
Sbjct: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK--NKVGREGIIPANYV 65
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 80.9 bits (198), Expect = 1e-15
Identities = 45/148 (30%), Positives = 81/148 (54%), Gaps = 13/148 (8%)
Query: 2 EAVAKFDFTASGEDELSFHTGDVLKILSNQEE--WFKAELG-SQEGYVPKNFID------ 52
E +AK++F + E +L F GDVL I++ ++ W+KA+ +EG +P N++
Sbjct: 13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVK 72
Query: 53 ----IQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVM 108
+ WFH ++R QAE LL E G F++R S + PGD+++ V + V+H+++M
Sbjct: 73 AGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIM 132
Query: 109 RDNKGNYFLWTEKFPSLNKLVDYYRTNS 136
F +L +LV++Y +++
Sbjct: 133 YHASKLSIDEEVYFENLMQLVEHYTSDA 160
Score = 31.6 bits (70), Expect = 1.0
Identities = 17/52 (32%), Positives = 31/52 (59%), Gaps = 6/52 (11%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLD-SSNPSWWTGRLHNKL---GLFPANYV 325
A Y+F + +L F G+V+ ++ + +P+W+ + NK+ G+ PANYV
Sbjct: 16 AKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAK--NKVGREGIIPANYV 65
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 80.5 bits (197), Expect = 2e-15
Identities = 52/163 (31%), Positives = 82/163 (50%), Gaps = 13/163 (7%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQ------EGYVPKNFI----DI 53
V +DF + ++ELSF GDV + +E+W+ A L + +GYVP N++ +
Sbjct: 14 VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73
Query: 54 QFPKWFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDN 111
+ WF +SR +A L G G F+IR S+ D+ +SVR V+H+K+ R
Sbjct: 74 ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRA 133
Query: 112 KGNYFL-WTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQ 153
G L F SL +LV+Y+R S+S ++ R E +
Sbjct: 134 GGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPE 176
Score = 34.7 bits (78), Expect = 0.12
Identities = 16/47 (34%), Positives = 22/47 (46%)
Query: 279 LYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYV 325
L+DF++ D+EL F +G+V V WW L G YV
Sbjct: 16 LWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYV 62
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 77.8 bits (190), Expect = 1e-14
Identities = 45/142 (31%), Positives = 79/142 (55%), Gaps = 13/142 (9%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAE--LGSQEGYVPKNFI----DIQFPK 57
VA +D+TA + +L G+ L++L +W+ A + +EGYVP NF+ ++ +
Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMER 123
Query: 58 WFHEGLSRHQAENLLMG--KEVGFFIIRASQSSPGDFSISVR----HEDDVQHFKVMRDN 111
WF R +AE L+ + G F+IR S+++ G FS+SV+ + ++H+K+ +
Sbjct: 124 WFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLD 183
Query: 112 KGNYFLWTE-KFPSLNKLVDYY 132
+G Y++ FPSL LV +Y
Sbjct: 184 EGGYYISPRITFPSLQALVQHY 205
Score = 36.2 bits (82), Expect = 0.041
Identities = 19/51 (37%), Positives = 29/51 (56%), Gaps = 3/51 (5%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVA 326
ALYD+ A+ D +L GE ++VL + WW R + + G P+N+VA
Sbjct: 65 ALYDYTAMNDRDLQMLKGEKLQVLKGTG-DWWLARSLVTGREGYVPSNFVA 114
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 76.6 bits (187), Expect = 3e-14
Identities = 47/144 (32%), Positives = 86/144 (59%), Gaps = 15/144 (10%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGS--QEGYVPKNFI----DIQFP 56
VA +D+ + E +LSF G+ L+I++N E +W+ A S Q GY+P N++ IQ
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
Query: 57 KWFHEGLSRHQAENLLMGKE--VGFFIIRASQSSPGDFSISVRHED-----DVQHFKVMR 109
+W+ ++R ++E LL+ E G F++R S+++ G + +SV D +V+H+K+ +
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
Query: 110 DNKGNYFLWTE-KFPSLNKLVDYY 132
+ G +++ + +F SL +LV YY
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYY 233
Score = 44.7 bits (104), Expect = 1e-04
Identities = 21/60 (35%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 270 AGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVAP 327
AG V ALYD+E+ + +L F GE +++++++ WW + G P+NYVAP
Sbjct: 83 AGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 76.6 bits (187), Expect = 3e-14
Identities = 47/144 (32%), Positives = 86/144 (59%), Gaps = 15/144 (10%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGS--QEGYVPKNFI----DIQFP 56
VA +D+ + E +LSF G+ L+I++N E +W+ A S Q GY+P N++ IQ
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
Query: 57 KWFHEGLSRHQAENLLMGKE--VGFFIIRASQSSPGDFSISVRHED-----DVQHFKVMR 109
+W+ ++R ++E LL+ E G F++R S+++ G + +SV D +V+H+K+ +
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
Query: 110 DNKGNYFLWTE-KFPSLNKLVDYY 132
+ G +++ + +F SL +LV YY
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYY 233
Score = 44.7 bits (104), Expect = 1e-04
Identities = 21/60 (35%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 270 AGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVAP 327
AG V ALYD+E+ + +L F GE +++++++ WW + G P+NYVAP
Sbjct: 83 AGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 76.6 bits (187), Expect = 3e-14
Identities = 46/144 (31%), Positives = 82/144 (56%), Gaps = 15/144 (10%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAE--LGSQEGYVPKNFI----DIQFP 56
+A +D+ A ED+L+F G+ IL+N E +W++A + G +P N++ IQ
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 57 KWFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVR-----HEDDVQHFKVMR 109
+W+ + R AE L+ G G F+IR S+++ G +S+S+R D V+H+K+ +
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 110 DNKGNYFLWTE-KFPSLNKLVDYY 132
+ G Y++ T +F S+ +LV +Y
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHY 226
Score = 50.1 bits (118), Expect = 3e-06
Identities = 23/53 (43%), Positives = 32/53 (60%), Gaps = 2/53 (3%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVAPM 328
ALYD+EA +D+L F GE +L+++ WW R K G P+NYVAP+
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 76.6 bits (187), Expect = 3e-14
Identities = 46/144 (31%), Positives = 82/144 (56%), Gaps = 15/144 (10%)
Query: 4 VAKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAE--LGSQEGYVPKNFI----DIQFP 56
+A +D+ A ED+L+F G+ IL+N E +W++A + G +P N++ IQ
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 57 KWFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVR-----HEDDVQHFKVMR 109
+W+ + R AE L+ G G F+IR S+++ G +S+S+R D V+H+K+ +
Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
Query: 110 DNKGNYFLWTE-KFPSLNKLVDYY 132
+ G Y++ T +F S+ +LV +Y
Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHY 226
Score = 50.1 bits (118), Expect = 3e-06
Identities = 23/53 (43%), Positives = 32/53 (60%), Gaps = 2/53 (3%)
Query: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGR--LHNKLGLFPANYVAPM 328
ALYD+EA +D+L F GE +L+++ WW R K G P+NYVAP+
Sbjct: 84 ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,451,246
Number of Sequences: 37866
Number of extensions: 744446
Number of successful extensions: 6096
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 361
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 4039
Number of HSP's gapped (non-prelim): 1666
length of query: 330
length of database: 18,247,518
effective HSP length: 103
effective length of query: 227
effective length of database: 14,347,320
effective search space: 3256841640
effective search space used: 3256841640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.