Search of human proteins with 47578115

Search of human proteins with 47578115

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
         (1606 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]         3236   0.0  
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]         1835   0.0  
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...  1831   0.0  
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...   223   2e-57
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...   223   2e-57
gi|23308553 spermatogenesis associated 13 [Homo sapiens]              208   4e-53
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]             205   3e-52
gi|189571664 DEP domain containing 6 [Homo sapiens]                   145   3e-34
gi|197116361 inositol polyphosphate-4-phosphatase, type 1 isofor...   124   6e-28
gi|197116359 inositol polyphosphate-4-phosphatase, type 1 isofor...   123   2e-27
gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform ...   122   2e-27
gi|71274148 pleckstrin homology domain containing, family G (wit...   117   1e-25
gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform ...   114   1e-24
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...   110   1e-23
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]   109   2e-23
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap...   109   2e-23
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ...   108   3e-23
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...   108   3e-23
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...   108   3e-23
gi|156104897 inositol polyphosphate-4-phosphatase, type II, 105k...   108   5e-23
gi|156104895 inositol polyphosphate-4-phosphatase, type II, 105k...   108   5e-23
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]    103   1e-21
gi|24797153 faciogenital dysplasia protein [Homo sapiens]             102   3e-21
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   102   4e-21
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]   100   2e-20
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    98   6e-20
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    98   6e-20
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...    97   1e-19
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    96   4e-19
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom...    96   4e-19

>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score = 3236 bits (8389), Expect = 0.0
 Identities = 1606/1606 (100%), Positives = 1606/1606 (100%)

Query: 1    MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK 60
            MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK
Sbjct: 1    MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK 60

Query: 61   VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD 120
            VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD
Sbjct: 61   VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD 120

Query: 121  EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL 180
            EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL
Sbjct: 121  EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL 180

Query: 181  KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT 240
            KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT
Sbjct: 181  KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT 240

Query: 241  DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300
            DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI
Sbjct: 241  DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300

Query: 301  NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER 360
            NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER
Sbjct: 301  NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER 360

Query: 361  ERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL 420
            ERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL
Sbjct: 361  ERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL 420

Query: 421  EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS 480
            EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS
Sbjct: 421  EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS 480

Query: 481  KGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLC 540
            KGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLC
Sbjct: 481  KGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLC 540

Query: 541  DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE 600
            DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE
Sbjct: 541  DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE 600

Query: 601  GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL 660
            GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL
Sbjct: 601  GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL 660

Query: 661  NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII 720
            NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII
Sbjct: 661  NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII 720

Query: 721  KVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEA 780
            KVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEA
Sbjct: 721  KVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEA 780

Query: 781  GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI 840
            GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI
Sbjct: 781  GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI 840

Query: 841  EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRI 900
            EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRI
Sbjct: 841  EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRI 900

Query: 901  SSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGV 960
            SSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGV
Sbjct: 901  SSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGV 960

Query: 961  QLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDL 1020
            QLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDL
Sbjct: 961  QLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDL 1020

Query: 1021 ETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEKGER 1080
            ETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEKGER
Sbjct: 1021 ETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEKGER 1080

Query: 1081 NSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDS 1140
            NSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDS
Sbjct: 1081 NSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDS 1140

Query: 1141 GDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEF 1200
            GDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEF
Sbjct: 1141 GDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEF 1200

Query: 1201 QQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQ 1260
            QQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQ
Sbjct: 1201 QQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQ 1260

Query: 1261 LRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHF 1320
            LRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHF
Sbjct: 1261 LRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHF 1320

Query: 1321 QSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVY 1380
            QSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVY
Sbjct: 1321 QSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVY 1380

Query: 1381 FYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEK 1440
            FYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEK
Sbjct: 1381 FYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEK 1440

Query: 1441 VKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACAN 1500
            VKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACAN
Sbjct: 1441 VKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACAN 1500

Query: 1501 TACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIM 1560
            TACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIM
Sbjct: 1501 TACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIM 1560

Query: 1561 QATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE 1606
            QATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE
Sbjct: 1561 QATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE 1606


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score = 1835 bits (4754), Expect = 0.0
 Identities = 905/905 (100%), Positives = 905/905 (100%)

Query: 1   MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK 60
           MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK
Sbjct: 1   MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASK 60

Query: 61  VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD 120
           VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD
Sbjct: 61  VDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYD 120

Query: 121 EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL 180
           EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL
Sbjct: 121 EYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLIL 180

Query: 181 KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT 240
           KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT
Sbjct: 181 KELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNIT 240

Query: 241 DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300
           DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI
Sbjct: 241 DTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300

Query: 301 NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER 360
           NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER
Sbjct: 301 NTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKER 360

Query: 361 ERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL 420
           ERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL
Sbjct: 361 ERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL 420

Query: 421 EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS 480
           EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS
Sbjct: 421 EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVIS 480

Query: 481 KGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLC 540
           KGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLC
Sbjct: 481 KGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLC 540

Query: 541 DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE 600
           DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE
Sbjct: 541 DNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNE 600

Query: 601 GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL 660
           GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL
Sbjct: 601 GSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCL 660

Query: 661 NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII 720
           NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII
Sbjct: 661 NSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCII 720

Query: 721 KVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEA 780
           KVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEA
Sbjct: 721 KVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEA 780

Query: 781 GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI 840
           GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI
Sbjct: 781 GDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI 840

Query: 841 EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRI 900
           EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRI
Sbjct: 841 EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRI 900

Query: 901 SSYKK 905
           SSYKK
Sbjct: 901 SSYKK 905


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
            exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 1831 bits (4743), Expect = 0.0
 Identities = 938/1639 (57%), Positives = 1207/1639 (73%), Gaps = 58/1639 (3%)

Query: 5    SRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKN 64
            S G     +A++ E+QLRLR+CVL+E+  TERDYVGTL FL SAFLHR+ Q  A  V+K 
Sbjct: 31   SSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKG 90

Query: 65   VTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCS 124
            +TEE VK+LFSNIEDIL VHK+FL  +E CLHPEP +Q E+G  FL FKDKF +Y+EYCS
Sbjct: 91   LTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCS 150

Query: 125  NHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELL 184
            NHEKA +LL+ELNKI T+R FLL+CMLLGGRK TD+PLEGYL++PIQRICKYPL+LKEL 
Sbjct: 151  NHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELA 210

Query: 185  KRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCT 244
            KRTP KH D+ AV  ALQAMK VCSNINE KRQMEKLE LE+ QSHIEGWEGSN+TD CT
Sbjct: 211  KRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICT 270

Query: 245  EMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKA-----STDGHRYLFRGR 299
            ++L+ G LLKIS+GNIQER FFLFDNLLVYCKRK R   + K+     S +G  Y+FRGR
Sbjct: 271  QLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGR 330

Query: 300  INTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
            INTEVMEVENV+DGTAD+HS+G+ V NGWKIHNTAKNKWFVCMAKT EEK +W +AI++E
Sbjct: 331  INTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIRE 390

Query: 360  RERRKGLKLGMEQDTWVMISEQGEKLYKMMC-RQGNLIKDRKRKLTTFPKCFLGSEFVSW 418
            RE+R+ LKLGME+D +VMI+E+GEKLY MM  ++ NLIKDR+RKL+T PKCFLG+EFV+W
Sbjct: 391  REQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAW 450

Query: 419  LLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDV 478
            LLEIGEI + EEGV+LGQALLENGIIHHV+DKHQFK EQ++YRFRYDDGT+  R+E++D+
Sbjct: 451  LLEIGEISKTEEGVNLGQALLENGIIHHVSDKHQFKNEQVMYRFRYDDGTYKARSELEDI 510

Query: 479  ISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVG 538
            +SKGVRLYCRLHSL+TPVI+D+DYHL+TYKSV+  +KL+DWL+AQGDC+TREEA+  GVG
Sbjct: 511  MSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVG 570

Query: 539  LCDNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKS 598
            LC+NGFMHHVLEKSEF+DE   FRF +DEEMEG++ K++ +++D K+VEN++AK LLI  
Sbjct: 571  LCNNGFMHHVLEKSEFRDESQYFRFHADEEMEGTSSKNKQLRNDFKLVENILAKRLLILP 630

Query: 599  NEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKS 658
             E  YGF +E+KNK  ++K V++GS AE+AG++VG+KI++IN DLVF+RPF+EV+  L  
Sbjct: 631  QEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRPFSEVESILNQ 690

Query: 659  CLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQC 718
               SR+PLR+LV+TK +E +KIPD  D L FQIRG  P  V+AVGRG+ A AAGL  GQC
Sbjct: 691  SFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAMAAGLCAGQC 750

Query: 719  IIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQE---DLQKSHSKP 775
            I+KVNG NV  +    V+ H  A R  RR       QW+Y++ E AQE     + S   P
Sbjct: 751  ILKVNGSNVMNDGAPEVLEHFQAFRS-RREEALGLYQWIYHTHEDAQEARASQEASTEDP 809

Query: 776  PGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNV 835
             G++A +         +        +      V+LTVDNVHLE+GVVYEY STAG++C+V
Sbjct: 810  SGEQAQEEDQADSAFPLLSLGPRLSLCEDSPMVTLTVDNVHLEHGVVYEYVSTAGVRCHV 869

Query: 836  VEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEH 895
            +EK++EP+G F LTAKILEA A +D  FV+NC  L +L+  I T    +F  +C  ++E 
Sbjct: 870  LEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMPHFEFRNICDTKLES 929

Query: 896  LCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLG 955
            + QRI+ Y++F+  LK+R  P FKQA  +  PL   DFCPTNCH+N+MEVSYPKT+ S+G
Sbjct: 930  IGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHINLMEVSYPKTTPSVG 989

Query: 956  SAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPS--------------GL 1001
             +F ++   +            EQG L+PM Y QH ITTMAAPS              GL
Sbjct: 990  RSFSIRFGRKP----SLIGLDPEQGHLNPMSYTQHCITTMAAPSWKCLPAAEGDPQGQGL 1045

Query: 1002 ----------SLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLL 1051
                      +LGQ+D  GL +LLK+ED E QD Y +L  KL  ALKE++  V QI+ LL
Sbjct: 1046 HDGSFGPASGTLGQED-RGLSFLLKQEDREIQDAYLQLFTKLDVALKEMKQYVTQINRLL 1104

Query: 1052 SSITY--------SPKLERKTSEGIIPTDSDNEKGERNS-KRVCFNVAGDEQEDSGHDTI 1102
            S+IT         +   E  +S  ++  +S+ ++ +    K+VCF VA ++QEDSGHDT+
Sbjct: 1105 STITEPTSGGSCDASLAEEASSLPLVSEESEMDRSDHGGIKKVCFKVAEEDQEDSGHDTM 1164

Query: 1103 SNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPLSVRISHDKQDKIHSCL 1162
            S RDSYS+CNSNR+S+ S+TS+ S+  SSY  SDEM SGDELP  +RI  DKQDK+H CL
Sbjct: 1165 SYRDSYSECNSNRDSVLSYTSVRSN--SSYLGSDEMGSGDELPCDMRIPSDKQDKLHGCL 1222

Query: 1163 EHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDP 1222
            EHLF+QVDSI  LLKG  + RAF++TK+      LQEF+Q+ E  +     +++ I++DP
Sbjct: 1223 EHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEFKQKEECTIRGRSLIQISIQEDP 1282

Query: 1223 WNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQLRRDMVFCQTLVATVCAFSEQL 1282
            WNLP+S++TL  NI+++VE+ K +LLLALL+ +D+E QLRRD +FCQ LVA VC FSEQL
Sbjct: 1283 WNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQLRRDAIFCQALVAAVCTFSEQL 1342

Query: 1283 MAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSP-NLTDEQAMLEDTLVA 1341
            +AAL   ++N+ E E  + +ASR+WL+Q+A  GVL H QSLLSP  + +E+ MLED  V 
Sbjct: 1343 LAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVT 1402

Query: 1342 LFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGGF 1401
            L +L+ V+F FK  +E   VAN  + Y  EGSRQALKV FY+DSYHF +LP RL+ G   
Sbjct: 1403 LSELDNVTFSFKQLDEN-YVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASL 1461

Query: 1402 KIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPN 1461
            ++H  LF + LE++EG     + + E+ Q  INA SLEKV+QY +KLRAFYL++SN P +
Sbjct: 1462 RLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTD 1521

Query: 1462 STSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSASGVGLLSVSSELCNRL 1521
            +++ A  +D+L+RP+NALDEL RL+ SF+  K  AA       + G GL+ +SSELC RL
Sbjct: 1522 ASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAA------GSVGAGLIPISSELCYRL 1575

Query: 1522 GACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLG 1581
            GAC ++MC +G+ R TLSV+LEQA ILARSHGL P+ IMQATD+MRKQG RV+  AKNL 
Sbjct: 1576 GACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNLR 1635

Query: 1582 VRDRTPQSAPRLYKLCEPP 1600
            V+D+ PQ APRLY+LC+PP
Sbjct: 1636 VKDQMPQGAPRLYRLCQPP 1654


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score =  223 bits (567), Expect = 2e-57
 Identities = 136/405 (33%), Positives = 222/405 (54%), Gaps = 40/405 (9%)

Query: 7   GDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVT 66
           G + A+S+KD     ++R  V++E+  TERDY+  L  +   ++ +  + A        +
Sbjct: 273 GGAEAQSSKD-----QMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM-----FS 322

Query: 67  EETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNH 126
           EE ++ +F NIEDI    K F+K +E+  + E     E+G CFL  +  F+IY EYC+NH
Sbjct: 323 EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNH 382

Query: 127 EKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKR 186
             A   L  L K+     F   C LL  +K  D+ L+G+L+TP+Q+ICKYPL L ELLK 
Sbjct: 383 PNACVELSRLTKLSKYVYFFEACRLL--QKMIDISLDGFLLTPVQKICKYPLQLAELLKY 440

Query: 187 TPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEM 246
           T  +H D+  V  AL AMK V   INE KR++E ++ + +WQS IE WEG ++    +E+
Sbjct: 441 THPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSEL 500

Query: 247 LMCGVLLKIS--SGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEV 304
           +  G L +++      Q+R+FFLFD+ L+YCK+   R              ++GR++ + 
Sbjct: 501 IYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLR---------RDVLYYKGRLDMDG 551

Query: 305 MEVENVDDG-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERR 363
           +EV +++DG   D H S   + N +++H  A     +   + PE+K  W +A  +ERE  
Sbjct: 552 LEVVDLEDGKDRDLHVS---IKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFARERE-- 606

Query: 364 KGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPK 408
              ++ ++Q+T   I+E        + R+  ++   K+++T  PK
Sbjct: 607 ---QVQLDQETGFSITE--------LQRKQAMLNASKQQVTGKPK 640


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score =  223 bits (567), Expect = 2e-57
 Identities = 136/405 (33%), Positives = 222/405 (54%), Gaps = 40/405 (9%)

Query: 7   GDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVT 66
           G + A+S+KD     ++R  V++E+  TERDY+  L  +   ++ +  + A        +
Sbjct: 273 GGAEAQSSKD-----QMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM-----FS 322

Query: 67  EETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNH 126
           EE ++ +F NIEDI    K F+K +E+  + E     E+G CFL  +  F+IY EYC+NH
Sbjct: 323 EEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNH 382

Query: 127 EKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKR 186
             A   L  L K+     F   C LL  +K  D+ L+G+L+TP+Q+ICKYPL L ELLK 
Sbjct: 383 PNACVELSRLTKLSKYVYFFEACRLL--QKMIDISLDGFLLTPVQKICKYPLQLAELLKY 440

Query: 187 TPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEM 246
           T  +H D+  V  AL AMK V   INE KR++E ++ + +WQS IE WEG ++    +E+
Sbjct: 441 THPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSEL 500

Query: 247 LMCGVLLKIS--SGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEV 304
           +  G L +++      Q+R+FFLFD+ L+YCK+   R              ++GR++ + 
Sbjct: 501 IYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLR---------RDVLYYKGRLDMDG 551

Query: 305 MEVENVDDG-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERR 363
           +EV +++DG   D H S   + N +++H  A     +   + PE+K  W +A  +ERE  
Sbjct: 552 LEVVDLEDGKDRDLHVS---IKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFARERE-- 606

Query: 364 KGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPK 408
              ++ ++Q+T   I+E        + R+  ++   K+++T  PK
Sbjct: 607 ---QVQLDQETGFSITE--------LQRKQAMLNASKQQVTGKPK 640


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score =  208 bits (529), Expect = 4e-53
 Identities = 135/387 (34%), Positives = 210/387 (54%), Gaps = 28/387 (7%)

Query: 2   SEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKV 61
           SE+   ++     +  E + ++R  V+ E+  TER Y+  L  +   ++    QC   K 
Sbjct: 219 SEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIR---QCR--KH 273

Query: 62  DKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDE 121
               T   +  +F NIEDI    ++FLK +E+  + E     E+G+CFL  ++ F IY E
Sbjct: 274 TGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSE 333

Query: 122 YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181
           YC+NH  A   L  L K    R F   C LL  ++  D+ ++G+L+TP+Q+ICKYPL L 
Sbjct: 334 YCNNHPGACLELANLMKQGKYRHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLA 391

Query: 182 ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITD 241
           ELLK T ++H DY+ +  A +AMK V   INE KR++E ++ +  WQ  I GWEG +I D
Sbjct: 392 ELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILD 451

Query: 242 TCTEMLMCGVLLKIS-SGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300
             +E++  G L KI+  G  Q+R FFLFD+ LV CK+   R              ++GR+
Sbjct: 452 RSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLR---------RDMLYYKGRL 502

Query: 301 NTEVMEVENVDDG-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
           + + ME+ ++ DG   D + S   V N +K+ +   ++ ++  AK  E+K  W +A   E
Sbjct: 503 DMDEMELVDLGDGRDKDCNLS---VKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADE 559

Query: 360 RER-RKGLKLGMEQDTWVMISEQGEKL 385
           R R ++  ++GME      ISE  +KL
Sbjct: 560 RRRVQEDKEMGME------ISENQKKL 580


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score =  205 bits (521), Expect = 3e-52
 Identities = 131/382 (34%), Positives = 209/382 (54%), Gaps = 29/382 (7%)

Query: 15  KDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLF 74
           + L+ + ++R  V++E+  TER Y+  L+ +   +L    QC   +     ++E +K++F
Sbjct: 95  RPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYL---KQCRKRR--DMFSDEQLKVIF 149

Query: 75  SNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLL 134
            NIEDI      F++ +E+  + +     E+G CFL  +D F IY EYC+NH  A   L 
Sbjct: 150 GNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELS 209

Query: 135 ELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDY 194
           +L K    + F   C LL  ++  D+ ++G+L+TP+Q+ICKYPL L ELLK T + HSDY
Sbjct: 210 KLMKDSRYQHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDY 267

Query: 195 AAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLK 254
             V  AL  M+ V   INE KR++E ++ + +WQ+ +  WEG +I D  +E++  G +  
Sbjct: 268 RYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAW 327

Query: 255 ISS--GNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDD 312
           I    G  Q+RVFFLFD+ +V CK+   R              ++GRI+ +  EV +++D
Sbjct: 328 IYQPYGRNQQRVFFLFDHQMVLCKKDLIR---------RDILYYKGRIDMDKYEVVDIED 378

Query: 313 G-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERER-RKGLKLGM 370
           G   DF+ S   + N +K+HN    +  +  AK  EEK  W  A  +ER+  ++  K+G 
Sbjct: 379 GRDDDFNVS---MKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAFREERKMVQEDEKIGF 435

Query: 371 EQDTWVMISEQGEKLYKMMCRQ 392
           E      ISE  ++   M  R+
Sbjct: 436 E------ISENQKRQAAMTVRK 451


>gi|189571664 DEP domain containing 6 [Homo sapiens]
          Length = 409

 Score =  145 bits (366), Expect = 3e-34
 Identities = 110/352 (31%), Positives = 172/352 (48%), Gaps = 14/352 (3%)

Query: 382 GEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLEN 441
           GE+L ++   +  +IKDR+  L T+P CF+  E + WL+E  E    E  + L Q L + 
Sbjct: 37  GEQL-RLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADR 95

Query: 442 GIIHHVTDKH-QFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDK 500
           GIIHHV D+H +FK  ++ YRFR DDGTF   NE++    +G RLY +L S    +++ +
Sbjct: 96  GIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVK-AFMRGQRLYEKLMSPENTLLQPR 154

Query: 501 DYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLL 560
           +     Y+   MA++ +DWL+ +G+  TR+EA      L ++G + HV  K  F D  LL
Sbjct: 155 EEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLL 214

Query: 561 FRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVE 620
           ++F  +       M+    K       +     L  +S++          +    IK+V 
Sbjct: 215 YQFRMNFRRRRRLMELLNEKSPSSQETHDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVS 274

Query: 621 KGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPL---RVLVSTKP--R 675
               + M+    G   +  +   +   P   V C  KS L  ++P+    +L    P  R
Sbjct: 275 AVRRSSMS--SCGSSGYFSSSPTLSSSP--PVLCNPKSVL--KRPVTSEELLTPGAPYAR 328

Query: 676 ETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINV 727
           +T  I   A G GF +RG  P  + AV     AAAAG+   Q ++ VNG+NV
Sbjct: 329 KTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNV 380



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 39/94 (41%), Positives = 54/94 (57%), Gaps = 3/94 (3%)

Query: 475 MQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMI 534
           M +V+  G +L  RLH     VI+D+ +HL+TY +  +A +LIDWLI   +   RE A+ 
Sbjct: 30  MAEVLVTGEQLRLRLHE--EKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIK 87

Query: 535 FGVGLCDNGFMHHVL-EKSEFKDEPLLFRFFSDE 567
               L D G +HHV  E  EFKD  L +RF  D+
Sbjct: 88  LMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDD 121



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 35/110 (31%), Positives = 64/110 (58%), Gaps = 4/110 (3%)

Query: 373 DTWVMISEQGEKLY-KMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEG 431
           D  V    +G++LY K+M  +  L++ R+ +   + + F+ SEF+ WL++ GE    +E 
Sbjct: 127 DNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEA 186

Query: 432 VHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISK 481
             L   L+E+GII HV++KH F    +LY+FR +   F  R  + +++++
Sbjct: 187 EQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMN---FRRRRRLMELLNE 233


>gi|197116361 inositol polyphosphate-4-phosphatase, type 1 isoform c
            [Homo sapiens]
          Length = 972

 Score =  124 bits (312), Expect = 6e-28
 Identities = 196/877 (22%), Positives = 341/877 (38%), Gaps = 169/877 (19%)

Query: 769  QKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEY--GVV---Y 823
            +KS  +PP   + D  + ++   +D+  T A+   + ++ SL  D +      G +   Y
Sbjct: 175  EKSDQRPPVTRSVDTVNGRMVLPVDESLTEAL-GIRSKYASLRKDTLLKSVFGGAICRMY 233

Query: 824  EYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQS 883
             + +T G    ++E+M E      +  + ++ L + D   V     L  L E+ P     
Sbjct: 234  RFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARV---CELEELGELSPC---- 286

Query: 884  KFSALCSERIEHLCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVM 943
             + +L  + +      I +Y++    L     P+FK +  K       +F PTN H+  M
Sbjct: 287  -WESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADK--KLEFVPTNLHIQRM 343

Query: 944  EVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSL 1003
                            VQ D     ++D                    I T+ AP+    
Sbjct: 344  R---------------VQDDGGSDQNYD--------------------IVTIGAPAAHCQ 368

Query: 1004 GQQDGHGLRYLL---KEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITY-SPK 1059
            G + G GLR  L   +E    T    Q ++   Q  ++  E+ + QI+ L + ++Y + +
Sbjct: 369  GFKSG-GLRKKLHKFEETKKHTSSGCQSIIYIPQDVVRAKEI-IAQINTLKTQVSYYAER 426

Query: 1060 LER----KTSEGIIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNR 1115
            L R    +++ G+  T +      R    VC             D     +S    N+ R
Sbjct: 427  LSRAAKDRSATGLERTLAILADKTRQLVTVC-------------DCKLLANSIHGLNAAR 473

Query: 1116 -NSIASFTSICSSQCSSYFHSDEMDS------GDELPLSVRISHDKQD------KIHSCL 1162
             + IAS  S  S++       ++ D+      G     S+++   +++       +   L
Sbjct: 474  PDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSL 533

Query: 1163 EHLFSQVDSITNL--LKGQAVVRAFDQTKYLTPGRGLQEFQQ------------------ 1202
            E +  +VD +     L G+     F      T  +G  +                     
Sbjct: 534  ECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCP 593

Query: 1203 EMEPKLSCPKRLRLHIKQDP-------WN--LPSSVRTLAQNIRKFVEEVKCRLLLALLE 1253
               P  +C   L  H    P       W+  L   + TL   +    ++ K  ++  L++
Sbjct: 594  STMPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQ 653

Query: 1254 YSDS------ETQLRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRW 1307
             S          Q RRD+VFCQTL A +C F  +L    N + D+              +
Sbjct: 654  DSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLR---NCLHDDG-------------F 697

Query: 1308 LDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLT 1367
            L Q+   G+L  F+SLLS    +E AMLED  + + DL  V+F    +        +P+ 
Sbjct: 698  LRQLYTIGLLAQFESLLS-TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVI 756

Query: 1368 YQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYR-DNVSV 1426
                G+R    V   +    F+ LP+ +++G   ++ PVLF   +   +    R  + S+
Sbjct: 757  ---TGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSL 813

Query: 1427 EEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLV 1486
            +E    IN  SL ++  Y ++ +    +  +  P S S+             L EL R +
Sbjct: 814  QEV---INVESLVRLNSYFEQFKEVLPE--DCLPRSRSQTC-----------LPELLRFL 857

Query: 1487 ASFIRSKRTAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAI 1546
               + +++             V +L  ++E+C RL       C S   R  +SVTLEQ +
Sbjct: 858  GQNVHARKN----------KNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCL 907

Query: 1547 ILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVR 1583
            IL   HG+ P+   QA + MR +G R +NT KN+G R
Sbjct: 908  ILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSR 944


>gi|197116359 inositol polyphosphate-4-phosphatase, type 1 isoform d
            [Homo sapiens]
          Length = 977

 Score =  123 bits (308), Expect = 2e-27
 Identities = 106/394 (26%), Positives = 171/394 (43%), Gaps = 62/394 (15%)

Query: 1206 PKLSCPKRLRLHIKQDP-------WN--LPSSVRTLAQNIRKFVEEVKCRLLLALLEYSD 1256
            P  +C   L  H    P       W+  L   + TL   +    ++ K  ++  L++ S 
Sbjct: 602  PSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSA 661

Query: 1257 S------ETQLRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQ 1310
                     Q RRD+VFCQTL A +C F  +L    N + D+              +L Q
Sbjct: 662  PTIATYLSLQYRRDVVFCQTLTALICGFIIKLR---NCLHDDG-------------FLRQ 705

Query: 1311 IANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQA 1370
            +   G+L  F+SLLS    +E AMLED  + + DL  V+F    +        +P+    
Sbjct: 706  LYTIGLLAQFESLLS-TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVI--- 761

Query: 1371 EGSRQALKVYFYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYR-DNVSVEEF 1429
             G+R    V   +    F+ LP+ +++G   ++ PVLF   +   +    R  + S++E 
Sbjct: 762  TGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEV 821

Query: 1430 QAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASF 1489
               IN  SL ++  Y ++ +    +  +  P S S+             L EL R +   
Sbjct: 822  ---INVESLVRLNSYFEQFKEVLPE--DCLPRSRSQTC-----------LPELLRFLGQN 865

Query: 1490 IRSKRTAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILA 1549
            + +++             V +L  ++E+C RL       C S   R  +SVTLEQ +IL 
Sbjct: 866  VHARKN----------KNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQ 915

Query: 1550 RSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVR 1583
              HG+ P+   QA + MR +G R +NT KN+G R
Sbjct: 916  HEHGMAPQVFTQALECMRSEGCRRENTMKNVGSR 949



 Score = 31.6 bits (70), Expect = 6.5
 Identities = 40/182 (21%), Positives = 76/182 (41%), Gaps = 16/182 (8%)

Query: 769 QKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEY--GVV---Y 823
           +KS  +PP   + D  + ++   +D+  T A+   + ++ SL  D +      G +   Y
Sbjct: 175 EKSDQRPPVTRSVDTVNGRMVLPVDESLTEAL-GIRSKYASLRKDTLLKSVFGGAICRMY 233

Query: 824 EYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQS 883
            + +T G    ++E+M E      +  + ++ L + D   V     L  L E+ P     
Sbjct: 234 RFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARV---CELEELGELSPC---- 286

Query: 884 KFSALCSERIEHLCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVM 943
            + +L  + +      I +Y++    L     P+FK +  K       +F PTN H+  M
Sbjct: 287 -WESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADK--KLEFVPTNLHIQRM 343

Query: 944 EV 945
            V
Sbjct: 344 RV 345


>gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform a
            [Homo sapiens]
          Length = 938

 Score =  122 bits (307), Expect = 2e-27
 Identities = 192/857 (22%), Positives = 337/857 (39%), Gaps = 163/857 (19%)

Query: 769  QKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEY--GVV---Y 823
            +KS  +PP   + D  + ++   +D+  T A+   + ++ SL  D +      G +   Y
Sbjct: 175  EKSDQRPPVTRSVDTVNGRMVLPVDESLTEAL-GIRSKYASLRKDTLLKSVFGGAICRMY 233

Query: 824  EYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQS 883
             + +T G    ++E+M E      +  + ++ L + D   V     L  L E+ P     
Sbjct: 234  RFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARV---CELEELGELSPC---- 286

Query: 884  KFSALCSERIEHLCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVM 943
             + +L  + +      I +Y++    L     P+FK +  K       +F PTN H+  M
Sbjct: 287  -WESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADK--KLEFVPTNLHIQRM 343

Query: 944  EVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSL 1003
                            VQ D     ++D                    I T+ AP+    
Sbjct: 344  R---------------VQDDGGSDQNYD--------------------IVTIGAPAAHCQ 368

Query: 1004 GQQDGHGLRYLLKE--------EDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSIT 1055
            G + G GLR  L +        E+  T    Q ++   Q  ++  E+ + QI+ L + ++
Sbjct: 369  GFKSG-GLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEI-IAQINTLKTQVS 426

Query: 1056 Y-SPKLER----KTSEGIIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTISNRDSYSD 1110
            Y + +L R    +++ G+  T +      R    VC             D     +S   
Sbjct: 427  YYAERLSRAAKDRSATGLERTLAILADKTRQLVTVC-------------DCKLLANSIHG 473

Query: 1111 CNSNR-NSIASFTSICSSQCSSYFHSDEMDS------GDELPLSVRISHDKQD------K 1157
             N+ R + IAS  S  S++       ++ D+      G     S+++   +++       
Sbjct: 474  LNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLN 533

Query: 1158 IHSCLEHLFSQVDSITNL--LKGQAVVRAFDQTKYLTPGRGLQEFQQEMEPKLSCPKRLR 1215
            +   LE +  +VD +     L G+     F      T  +      +E  P         
Sbjct: 534  VDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSP--------- 584

Query: 1216 LHIKQDPWN--LPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDS------ETQLRRDMVF 1267
                   W+  L   + TL   +    ++ K  ++  L++ S          Q RRD+VF
Sbjct: 585  -----GEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVF 639

Query: 1268 CQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPN 1327
            CQTL A +C F  +L    N + D+              +L Q+   G+L  F+SLLS  
Sbjct: 640  CQTLTALICGFIIKLR---NCLHDDG-------------FLRQLYTIGLLAQFESLLS-T 682

Query: 1328 LTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYH 1387
              +E AMLED  + + DL  V+F    +        +P+     G+R    V   +    
Sbjct: 683  YGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVI---TGNRDGFNVRVPLPGPL 739

Query: 1388 FEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYR-DNVSVEEFQAQINAASLEKVKQYNQ 1446
            F+ LP+ +++G   ++ PVLF   +   +    R  + S++E    IN  SL ++  Y +
Sbjct: 740  FDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEV---INVESLVRLNSYFE 796

Query: 1447 KLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSAS 1506
            + +    +  +  P S S+             L EL R +   + +++            
Sbjct: 797  QFKEVLPE--DCLPRSRSQTC-----------LPELLRFLGQNVHARKN----------K 833

Query: 1507 GVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVM 1566
             V +L  ++E+C RL       C S   R  +SVTLEQ +IL   HG+ P+   QA + M
Sbjct: 834  NVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECM 893

Query: 1567 RKQGARVQNTAKNLGVR 1583
            R +G R +NT KN+G R
Sbjct: 894  RSEGCRRENTMKNVGSR 910


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  117 bits (292), Expect = 1e-25
 Identities = 78/255 (30%), Positives = 130/255 (50%), Gaps = 20/255 (7%)

Query: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
           V+ E+ +TER YV  L+ +V  +L     C   +    +  E    LF NI+DI   + E
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYL----DCIRDQTKLPLGTEERSALFGNIQDIYHFNSE 172

Query: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146
            L+ +E C     N    +  CF+   ++F IY +YC+N+ ++  +L E  + + +  F 
Sbjct: 173 LLQDLENC----ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFF 228

Query: 147 LNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQA 203
                   R+ T    +PL  YL+ P+QRI KY L+L E+     +    Y  V++A+  
Sbjct: 229 RE------RQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDT 282

Query: 204 MKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQER 263
           M+ V  +IN+ KR+ E    L+E QS +  W+G ++T +  E+++ G      + N  ER
Sbjct: 283 MQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLT-SYGELVLEGTFRIQRAKN--ER 339

Query: 264 VFFLFDNLLVYCKRK 278
             FLFD LL+  K++
Sbjct: 340 TLFLFDKLLLITKKR 354


>gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform b
            [Homo sapiens]
          Length = 954

 Score =  114 bits (284), Expect = 1e-24
 Identities = 190/854 (22%), Positives = 332/854 (38%), Gaps = 163/854 (19%)

Query: 769  QKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEY--GVV---Y 823
            +KS  +PP   + D  + ++   +D+  T A+   + ++ SL  D +      G +   Y
Sbjct: 175  EKSDQRPPVTRSVDTVNGRMVLPVDESLTEAL-GIRSKYASLRKDTLLKSVFGGAICRMY 233

Query: 824  EYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQS 883
             + +T G    ++E+M E      +  + ++ L + D   V     L  L E+ P     
Sbjct: 234  RFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARV---CELEELGELSPC---- 286

Query: 884  KFSALCSERIEHLCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVM 943
             + +L  + +      I +Y++    L     P+FK +  K       +F PTN H+  M
Sbjct: 287  -WESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADK--KLEFVPTNLHIQRM 343

Query: 944  EVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSL 1003
                            VQ D     ++D                    I T+ AP+    
Sbjct: 344  R---------------VQDDGGSDQNYD--------------------IVTIGAPAAHCQ 368

Query: 1004 GQQDGHGLRYLLKE--------EDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSIT 1055
            G + G GLR  L +        E+  T    Q ++   Q  ++  E+ + QI+ L + ++
Sbjct: 369  GFKSG-GLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEI-IAQINTLKTQVS 426

Query: 1056 Y-SPKLER----KTSEGIIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTISNRDSYSD 1110
            Y + +L R    +++ G+  T +      R    VC             D     +S   
Sbjct: 427  YYAERLSRAAKDRSATGLERTLAILADKTRQLVTVC-------------DCKLLANSIHG 473

Query: 1111 CNSNR-NSIASFTSICSSQCSSYFHSDEMDS------GDELPLSVRISHDKQD------K 1157
             N+ R + IAS  S  S++       ++ D+      G     S+++   +++       
Sbjct: 474  LNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLN 533

Query: 1158 IHSCLEHLFSQVDSITNL--LKGQAVVRAFDQTKYLTPGRGLQEFQQEMEPKLSCPKRLR 1215
            +   LE +  +VD +     L G+     F      T  +      +E  P         
Sbjct: 534  VDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSP--------- 584

Query: 1216 LHIKQDPWN--LPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDS------ETQLRRDMVF 1267
                   W+  L   + TL   +    ++ K  ++  L++ S          Q RRD+VF
Sbjct: 585  -----GEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVF 639

Query: 1268 CQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPN 1327
            CQTL A +C F  +L    N + D+              +L Q+   G+L  F+SLLS  
Sbjct: 640  CQTLTALICGFIIKLR---NCLHDDG-------------FLRQLYTIGLLAQFESLLS-T 682

Query: 1328 LTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYH 1387
              +E AMLED  + + DL  V+F    +        +P+     G+R    V   +    
Sbjct: 683  YGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVI---TGNRDGFNVRVPLPGPL 739

Query: 1388 FEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYR-DNVSVEEFQAQINAASLEKVKQYNQ 1446
            F+ LP+ +++G   ++ PVLF   +   +    R  + S++E    IN  SL ++  Y +
Sbjct: 740  FDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEV---INVESLVRLNSYFE 796

Query: 1447 KLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSAS 1506
            + +    +  +  P S S+             L EL R +   + +++            
Sbjct: 797  QFKEVLPE--DCLPRSRSQTC-----------LPELLRFLGQNVHARKN----------K 833

Query: 1507 GVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVM 1566
             V +L  ++E+C RL       C S   R  +SVTLEQ +IL   HG+ P+   QA + M
Sbjct: 834  NVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECM 893

Query: 1567 RKQGARVQNTAKNL 1580
            R  G R   T KNL
Sbjct: 894  RSIGTREVVTQKNL 907


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score =  110 bits (275), Expect = 1e-23
 Identities = 98/335 (29%), Positives = 156/335 (46%), Gaps = 32/335 (9%)

Query: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83
           R C L E+Q+TE  Y  TLE +   ++  + +   S  D       +  +F N+ED++ V
Sbjct: 199 RNCCLLEIQETEAKYYRTLEDIEKNYMSPL-RLVLSPAD-------MAAVFINLEDLIKV 250

Query: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT-I 142
           H  FL+ ++  +    +   +V   FL FK++  IY EYCS+ E AQ  L +L   R   
Sbjct: 251 HHSFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 307

Query: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202
           R  +  C L    ++    L+  LV P+QR+ KY L+LKELL  +  +  +   + EAL+
Sbjct: 308 RQKVEECTLKV--QDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAER-PERQQLKEALE 364

Query: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVL--LKISSGNI 260
           AM+ +   INE KR  E L  + E+QS IE  +     +      + G L    I +   
Sbjct: 365 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 422

Query: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320
           Q+R  FLFD +++ CKRK            G+ Y  +  I     ++ +      D   S
Sbjct: 423 QDRYLFLFDKVVIVCKRK------------GYSYELKEIIELLFHKMTDDPMNNKDVKKS 470

Query: 321 -GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFE 354
            G +   G+ + +    + F    KT + K +W E
Sbjct: 471 HGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWME 505


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score =  109 bits (273), Expect = 2e-23
 Identities = 101/382 (26%), Positives = 172/382 (45%), Gaps = 37/382 (9%)

Query: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
           ++ EL +TE+ YV  L  L   F   + + A S   K   E+ V+++FSNI  I   H +
Sbjct: 106 IVQELLETEQAYVARLHLLDQVFFQELLKTARSS--KAFPEDVVRVIFSNISSIYQFHSQ 163

Query: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146
           F     +    +  A   +G          ++Y EY  N E+A +LL        +   +
Sbjct: 164 FFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEV 223

Query: 147 LNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKA 206
           L   +     +  + L+ +++ P+QRI +Y L+LKE +++ P +  D A   +AL  + +
Sbjct: 224 LT-RIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFS 282

Query: 207 VCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNIQERV 264
              + N A  +ME+L+ L  W+ +       +I D    +L  G +LKIS    +  ER 
Sbjct: 283 AAQHSNAAITEMERLQDL--WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERY 340

Query: 265 FFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIV 324
            FLF+N+L+YC  +  ++        G ++  R RI+   M+V  + D  A+F  S   +
Sbjct: 341 LFLFNNMLLYCVPRVIQV--------GAQFQVRTRIDVAGMKVRELMD--AEFPHS--FL 388

Query: 325 VNGWKIHNTAKNKWFVCMAKTPEEKHEWFEA-------ILKERERRKGLKLGMEQDTWVM 377
           V+G       K +     A++ EE   W +A       I K  E  K    G E D    
Sbjct: 389 VSG-------KQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGD---- 437

Query: 378 ISEQGEKLYKMMCRQGNLIKDR 399
           I EQ  +  ++  R    ++D+
Sbjct: 438 IQEQELQSEELGLRAPQWVRDK 459


>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
          Length = 1591

 Score =  109 bits (272), Expect = 2e-23
 Identities = 100/395 (25%), Positives = 193/395 (48%), Gaps = 42/395 (10%)

Query: 3    EDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVD 62
            +DS G   A + + L    +LR  V+ EL +TER YV  L  L+  +L  + +      +
Sbjct: 1022 QDSTGPQLA-TMRQLSDADKLRK-VICELLETERTYVKDLNCLMERYLKPLQK------E 1073

Query: 63   KNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFL 110
              +T++ + +LF N+ +++    EFLK +E+ +   P+ ++             +G  FL
Sbjct: 1074 TFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFL 1133

Query: 111  HFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPI 170
            ++ D+F++Y  +C++H K  K+L++       + FL        ++     LE YL+ PI
Sbjct: 1134 YYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFL---DAQNPKQQHSSTLESYLIKPI 1190

Query: 171  QRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSH 230
            QRI KYPL+L+EL   T  +  ++  +  A++ M  V S+INE ++  E+   + +    
Sbjct: 1191 QRILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIA 1250

Query: 231  IEGWEGSNITD-TCTEMLMCGVLLKI----SSGNIQ---ERVFFLFDN--LLVY---CKR 277
             +  E   + D +  ++L+   ++ +    S G  +   E   F+F    +LVY    K+
Sbjct: 1251 EQTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQ 1310

Query: 278  KHRRLKNSKAS--TDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAK 335
            K + + + + S   D   + FR  I TE ++V  +    A+ ++   IV    +     +
Sbjct: 1311 KKKLVGSHRLSIYEDWDPFRFRHMIPTEALQVRALASADAEANAVCEIVHVKSESEGRPE 1370

Query: 336  NKWFVCMAKTPEEKHEWFEA---ILKERERRKGLK 367
              + +C   +PE + ++ +A   IL+++ RR+ LK
Sbjct: 1371 RVFHLC-CSSPESRKDFLKAVHSILRDKHRRQLLK 1404


>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
           [Homo sapiens]
          Length = 626

 Score =  108 bits (271), Expect = 3e-23
 Identities = 100/380 (26%), Positives = 176/380 (46%), Gaps = 40/380 (10%)

Query: 14  AKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKML 73
           A+ L    RLR  V+ EL  TE+ YV  L  L   +L  +        +  +T++ ++ L
Sbjct: 16  ARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN------ETFLTQDEMESL 68

Query: 74  FSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFLHFKDKFRIYDE 121
           F ++ ++L   K FL+ +E+ +    +                +G  FL++ D F++Y  
Sbjct: 69  FGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSG 128

Query: 122 YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181
           +C+NH K QK+L      +  + FL         K     LE YL+ P+QR+ KYPL+LK
Sbjct: 129 FCANHIKVQKVLERAKTDKAFKAFL---DARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 185

Query: 182 ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKL-EVLEEWQSHIEGWEGSNIT 240
           EL+  T ++  ++  + EAL+AM+ V S+INE ++  E    V ++  +   G E     
Sbjct: 186 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE 245

Query: 241 DTCTEMLMCGVLL----KISSGNIQ---ERVFFLFDN--LLVY---CKRKHRRLKNSKA- 287
            +  E+LM   +      +S G  +   E   F+F    +LVY   CK K +   NS+  
Sbjct: 246 LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA 305

Query: 288 --STDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKT 345
             STD   + FR  I    ++V   +    + +S   ++    +I    +  + +C + +
Sbjct: 306 HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS 365

Query: 346 PEEKH--EWFEAILKERERR 363
             + +  +   +IL+E  RR
Sbjct: 366 ESKTNIVKVIRSILRENFRR 385


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
            sapiens]
          Length = 1701

 Score =  108 bits (271), Expect = 3e-23
 Identities = 100/380 (26%), Positives = 176/380 (46%), Gaps = 40/380 (10%)

Query: 14   AKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKML 73
            A+ L    RLR  V+ EL  TE+ YV  L  L   +L  +        +  +T++ ++ L
Sbjct: 1091 ARHLSDADRLRK-VIQELVDTEKSYVKDLSCLFELYLEPLQN------ETFLTQDEMESL 1143

Query: 74   FSNIEDILAVHKEFLKVVEECLHPEPNAQQ------------EVGTCFLHFKDKFRIYDE 121
            F ++ ++L   K FL+ +E+ +    +                +G  FL++ D F++Y  
Sbjct: 1144 FGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSG 1203

Query: 122  YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181
            +C+NH K QK+L      +  + FL         K     LE YL+ P+QR+ KYPL+LK
Sbjct: 1204 FCANHIKVQKVLERAKTDKAFKAFL---DARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 1260

Query: 182  ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKL-EVLEEWQSHIEGWEGSNIT 240
            EL+  T ++  ++  + EAL+AM+ V S+INE ++  E    V ++  +   G E     
Sbjct: 1261 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTE 1320

Query: 241  DTCTEMLMCGVLL----KISSGNIQ---ERVFFLFDN--LLVY---CKRKHRRLKNSKA- 287
             +  E+LM   +      +S G  +   E   F+F    +LVY   CK K +   NS+  
Sbjct: 1321 LSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPA 1380

Query: 288  --STDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKT 345
              STD   + FR  I    ++V   +    + +S   ++    +I    +  + +C + +
Sbjct: 1381 HNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDS 1440

Query: 346  PEEKH--EWFEAILKERERR 363
              + +  +   +IL+E  RR
Sbjct: 1441 ESKTNIVKVIRSILRENFRR 1460


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score =  108 bits (271), Expect = 3e-23
 Identities = 85/258 (32%), Positives = 131/258 (50%), Gaps = 19/258 (7%)

Query: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83
           R C L E+Q+TE  Y  TLE +   ++  + +   S  D       +  +F N+ED++ V
Sbjct: 194 RNCCLLEIQETEAKYYRTLEDIEKNYMSPL-RLVLSPAD-------MAAVFINLEDLIKV 245

Query: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT-I 142
           H  FL+ ++  +    +   +V   FL FK++  IY EYCS+ E AQ  L +L   R   
Sbjct: 246 HHSFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 302

Query: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202
           R  +  C L    ++    L+  LV P+QR+ KY L+LKELL  +  +  +   + EAL+
Sbjct: 303 RQKVEECTLKV--QDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAER-PERQQLKEALE 359

Query: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVL--LKISSGNI 260
           AM+ +   INE KR  E L  + E+QS IE  +     +      + G L    I +   
Sbjct: 360 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 417

Query: 261 QERVFFLFDNLLVYCKRK 278
           Q+R  FLFD +++ CKRK
Sbjct: 418 QDRYLFLFDKVVIVCKRK 435


>gi|156104897 inositol polyphosphate-4-phosphatase, type II, 105kD
            [Homo sapiens]
          Length = 924

 Score =  108 bits (269), Expect = 5e-23
 Identities = 105/389 (26%), Positives = 176/389 (45%), Gaps = 59/389 (15%)

Query: 1203 EMEPKLSCPKRLRLHIKQDPWN-LPSSVRTLAQNIRKFVEEVKCRLLLALLE---YSDSE 1258
            E EP L+    +  H ++D +  L   + TL   + + V   K  L   LL+   YS  +
Sbjct: 559  EKEPSLT--DAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQ 616

Query: 1259 T---QLRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAG 1315
                 LRRD+VF Q L   VC F  +L  +L   +D               +L Q+   G
Sbjct: 617  CLMLTLRRDIVFSQALAGLVCGFIIKLQTSL---YDPG-------------FLQQLHTVG 660

Query: 1316 VLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQ 1375
            ++  ++ LLS   +DE  MLED  V + DL+KV+F    ++   ++  +       G R+
Sbjct: 661  LIVQYEGLLS-TYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVIT------GRRE 713

Query: 1376 ALKVYFYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYR-DNVSVEEFQAQIN 1434
               V   + +  FE LP ++K G    ++PVLF   +   +    R  +VS++E    IN
Sbjct: 714  HYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQE---SIN 770

Query: 1435 AASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKR 1494
              + E +++Y +     +++K   PP+  S         +  N L  L   +   I+SK+
Sbjct: 771  QENFELLQEYYK----IFMEKM--PPDYISH-------FQEQNDLKALLENLLQNIQSKK 817

Query: 1495 TAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGL 1554
                         V ++ +++ +C +L       C S   R ++SVTLEQ  IL   H L
Sbjct: 818  R----------KNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQL 867

Query: 1555 PPRYIMQATDVMRKQGARVQNTAKNLGVR 1583
               + ++A D MR++G R++N  KN+  R
Sbjct: 868  HKDFFIRALDCMRREGCRIENVLKNIKCR 896


>gi|156104895 inositol polyphosphate-4-phosphatase, type II, 105kD
            [Homo sapiens]
          Length = 924

 Score =  108 bits (269), Expect = 5e-23
 Identities = 105/389 (26%), Positives = 176/389 (45%), Gaps = 59/389 (15%)

Query: 1203 EMEPKLSCPKRLRLHIKQDPWN-LPSSVRTLAQNIRKFVEEVKCRLLLALLE---YSDSE 1258
            E EP L+    +  H ++D +  L   + TL   + + V   K  L   LL+   YS  +
Sbjct: 559  EKEPSLT--DAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQ 616

Query: 1259 T---QLRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAG 1315
                 LRRD+VF Q L   VC F  +L  +L   +D               +L Q+   G
Sbjct: 617  CLMLTLRRDIVFSQALAGLVCGFIIKLQTSL---YDPG-------------FLQQLHTVG 660

Query: 1316 VLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQ 1375
            ++  ++ LLS   +DE  MLED  V + DL+KV+F    ++   ++  +       G R+
Sbjct: 661  LIVQYEGLLS-TYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVIT------GRRE 713

Query: 1376 ALKVYFYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYR-DNVSVEEFQAQIN 1434
               V   + +  FE LP ++K G    ++PVLF   +   +    R  +VS++E    IN
Sbjct: 714  HYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQE---SIN 770

Query: 1435 AASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKR 1494
              + E +++Y +     +++K   PP+  S         +  N L  L   +   I+SK+
Sbjct: 771  QENFELLQEYYK----IFMEKM--PPDYISH-------FQEQNDLKALLENLLQNIQSKK 817

Query: 1495 TAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGL 1554
                         V ++ +++ +C +L       C S   R ++SVTLEQ  IL   H L
Sbjct: 818  R----------KNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQL 867

Query: 1555 PPRYIMQATDVMRKQGARVQNTAKNLGVR 1583
               + ++A D MR++G R++N  KN+  R
Sbjct: 868  HKDFFIRALDCMRREGCRIENVLKNIKCR 896


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score =  103 bits (258), Expect = 1e-21
 Identities = 90/332 (27%), Positives = 147/332 (44%), Gaps = 30/332 (9%)

Query: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83
           R C L E+Q+TE  Y  TL  +   FL          + + +  + ++++F NIED+L V
Sbjct: 195 RCCCLREIQQTEEKYTDTLGSIQQHFL--------KPLQRFLKPQDIEIIFINIEDLLRV 246

Query: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIR-TI 142
           H  FLK ++E L   P A   +   F+ +K++F +Y  YCS  E A K L  +   R  +
Sbjct: 247 HTHFLKEMKEAL-GTPGA-ANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDV 304

Query: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202
           +  L  C       N    L   L+ P+QR+ KY L+L+EL+K T ++  +   +  AL 
Sbjct: 305 QMKLEECSQRA--NNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLALD 361

Query: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQE 262
           AM+ +   +NE KR  E L  +  +Q  IE  + S       ++     +  +   +  +
Sbjct: 362 AMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMD 421

Query: 263 RVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGH 322
           R  FL D  L+ CKR+            G  Y  +  +N    +V +   G  D     H
Sbjct: 422 RYAFLLDKALLICKRR------------GDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSH 469

Query: 323 IVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFE 354
           + +    +      + +    KT E K +W E
Sbjct: 470 MFL----LIEDQGAQGYELFFKTRELKKKWME 497


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score =  102 bits (254), Expect = 3e-21
 Identities = 91/351 (25%), Positives = 165/351 (47%), Gaps = 36/351 (10%)

Query: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
           + +EL +TE+ YV  L  L   F  R+ + A ++   +   + V  +FSNI  I   H++
Sbjct: 377 IANELLQTEKAYVSRLHLLDQVFCARLLEEARNR--SSFPADVVHGIFSNICSIYCFHQQ 434

Query: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFL 146
           FL    E    E +    +G          ++Y EY  N ++A    +EL    T R+  
Sbjct: 435 FLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRA----VELVNTWTERSTQ 490

Query: 147 LNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQA 203
              ++   +K     ++ L+ +++ P+QRI +Y L+LK+ L + P    D     ++L+ 
Sbjct: 491 FKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLEL 550

Query: 204 MKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNIQ 261
           +     + N A R+ME++  L +    + G E  +I     E++  G +LK+S  +G  Q
Sbjct: 551 IATAAEHSNAAIRKMERMHKLLKVYELLGGEE--DIVSPTKELIKEGHILKLSAKNGTTQ 608

Query: 262 ERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSG 321
           +R   LF++ L+YC  + R L        G ++  R RI+ + ME++     +++ +   
Sbjct: 609 DRYLILFNDRLLYCVPRLRLL--------GQKFSVRARIDVDGMELKE----SSNLNLPR 656

Query: 322 HIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAI----LKERERRKGLKL 368
             +V+G       K +     A+T EEK +W +AI    LK  +  +  KL
Sbjct: 657 TFLVSG-------KQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKL 700


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  102 bits (253), Expect = 4e-21
 Identities = 84/281 (29%), Positives = 139/281 (49%), Gaps = 22/281 (7%)

Query: 20   QLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKV-DKNVTEETVKMLFSNIE 78
            Q+ +R  V   L  TE+ YV +L  L+  ++  + Q   S + D ++ +E    +F  I 
Sbjct: 1063 QVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDE----IFDQIP 1118

Query: 79   DILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDK---FRIYDEYCSNHEKAQKLLLE 135
            ++L  H++FL+ V  C+    +AQQ+VG   +    K     IY  Y  N   A+  +  
Sbjct: 1119 ELLEHHEQFLEQVRHCMQTW-HAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRV 1177

Query: 136  LNKIR-TIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDY 194
              + R     FL   M     K     L   ++ P+QRI +Y L++K+LLK TP  H D+
Sbjct: 1178 AKEARPAFLKFLEQSMRENKEKQA---LSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH 1234

Query: 195  AAVMEALQAMKAVCSNINEAKRQMEKLE----VLEEWQSHIEGWEGSNITDTCTEMLMCG 250
              ++EA + +K V   IN+  R  E+ E    VL+E ++HIEG E  ++       L   
Sbjct: 1235 PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGME--DLQAPLRRFLRQE 1292

Query: 251  VLLKISS-GNIQERVFFLFDNLLV--YCKRKHRRLKNSKAS 288
            +++++ + G  ++R  FLF +L+V    KRK   L+ S  S
Sbjct: 1293 MVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMS 1333


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 35/336 (10%)

Query: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
           + +EL  TER YV  L+ L   F  ++ + A      +   E V  +FSNI  I A H +
Sbjct: 210 IANELLLTERAYVNRLDLLDQVFYCKLLEEANRG---SFPAEMVNKIFSNISSINAFHSK 266

Query: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNK----IRTI 142
           FL    E    E      +G          ++Y EY    + A +L+  + +     +++
Sbjct: 267 FLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326

Query: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202
              +    + G      + L+ +++ P+QRI +Y ++LK+ L++ P    D+    ++L+
Sbjct: 327 VEEIQKQKICGS-----LTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLE 381

Query: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGN--I 260
            +    S+ N A R+ME L+ L E    +   E  +I +   E++  G +LK+++ N   
Sbjct: 382 IISTAASHSNSAIRKMENLKKLLEIYEML--GEEEDIVNPSNELIKEGQILKLAARNTSA 439

Query: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320
           QER  FLF+N+L+YC          K S  G ++  R R+  + M++  V+    ++  +
Sbjct: 440 QERYLFLFNNMLLYCV--------PKFSLVGSKFTVRTRVGIDGMKI--VETQNEEYPHT 489

Query: 321 GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAI 356
             +         + K +     A + ++K EW +A+
Sbjct: 490 FQV---------SGKERTLELQASSAQDKEEWIKAL 516


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 84/344 (24%), Positives = 157/344 (45%), Gaps = 38/344 (11%)

Query: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
           +  EL  TE  YV  L  L   F  R+        D  +  E +  +FSNI  I   H +
Sbjct: 161 IAQELLHTEETYVKRLHLLDQVFCTRLT-------DAGIPPEVIMGIFSNISSIHRFHGQ 213

Query: 87  FL-KVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTF 145
           FL   ++  +  E +    +G          ++Y EY  N ++A  L+       T R+ 
Sbjct: 214 FLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLV----STWTQRSP 269

Query: 146 LLNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202
           L   ++   +K     ++ L+ +++ P+QR+ +Y L+LK+ LKR P+   D      +L+
Sbjct: 270 LFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLE 329

Query: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNI 260
            +    ++ N A R++EK+  L E    + G E  +I +   E++  G + K+S  +G  
Sbjct: 330 LISTAANHSNAAIRKVEKMHKLLEVYEQLGGEE--DIVNPANELIKEGQIQKLSAKNGTP 387

Query: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320
           Q+R  FLF+++++YC  K R +        G ++  R +++   ++V+++        ++
Sbjct: 388 QDRHLFLFNSMILYCVPKLRLM--------GQKFSVREKMDISGLQVQDIVK-----PNT 434

Query: 321 GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRK 364
            H  +       T + +      +T EEK EW + I    E+ K
Sbjct: 435 AHTFI------ITGRKRSLELQTRTEEEKKEWIQIIQATIEKHK 472


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 98.2 bits (243), Expect = 6e-20
 Identities = 84/344 (24%), Positives = 157/344 (45%), Gaps = 38/344 (11%)

Query: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
           +  EL  TE  YV  L  L   F  R+        D  +  E +  +FSNI  I   H +
Sbjct: 161 IAQELLHTEETYVKRLHLLDQVFCTRLT-------DAGIPPEVIMGIFSNISSIHRFHGQ 213

Query: 87  FL-KVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTF 145
           FL   ++  +  E +    +G          ++Y EY  N ++A  L+       T R+ 
Sbjct: 214 FLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLV----STWTQRSP 269

Query: 146 LLNCMLLGGRKNT---DVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202
           L   ++   +K     ++ L+ +++ P+QR+ +Y L+LK+ LKR P+   D      +L+
Sbjct: 270 LFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLE 329

Query: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS--SGNI 260
            +    ++ N A R++EK+  L E    + G E  +I +   E++  G + K+S  +G  
Sbjct: 330 LISTAANHSNAAIRKVEKMHKLLEVYEQLGGEE--DIVNPANELIKEGQIQKLSAKNGTP 387

Query: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320
           Q+R  FLF+++++YC  K R +        G ++  R +++   ++V+++        ++
Sbjct: 388 QDRHLFLFNSMILYCVPKLRLM--------GQKFSVREKMDISGLQVQDIVK-----PNT 434

Query: 321 GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRK 364
            H  +       T + +      +T EEK EW + I    E+ K
Sbjct: 435 AHTFI------ITGRKRSLELQTRTEEEKKEWIQIIQATIEKHK 472


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 96/346 (27%), Positives = 150/346 (43%), Gaps = 61/346 (17%)

Query: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
           ++ E+  TER Y+  LE +   F     + A  K D  +    + +LFSNI+ I   H+ 
Sbjct: 539 IVKEILATERTYLKDLEVITVWF-----RSAVVKEDA-MPATLMTLLFSNIDPIYEFHRG 592

Query: 87  FLKVVEECL---------HPEPNAQQEVGTCFLH-------FKDKFRIYDEYCSNHEKAQ 130
           FL+ VE+ L         H +  + Q +G   L        F   F+ +DE  +  EKA 
Sbjct: 593 FLREVEQRLALWEGPSKAHTK-GSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKAT 651

Query: 131 KLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRK 190
           K   +L  +   + F L       +K   +PL  +L+ PIQR+  Y L+L+ L       
Sbjct: 652 KRCKKLEAV--YKEFEL-------QKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPG 702

Query: 191 HSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCG 250
           H DYA   +AL+A+  V + +     ++E L+ L E Q  + G E  N+     E +  G
Sbjct: 703 HHDYADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIE--NLIAPGREFIREG 760

Query: 251 VLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENV 310
            L K++   +Q+R+FFLF ++L+Y          SK       +  RG +  + M VE  
Sbjct: 761 CLHKLTKKGLQQRMFFLFSDMLLY---------TSKGVAGTSHFRIRGLLPLQGMLVEES 811

Query: 311 DDGTADFHSSGHIVVNGWKIHNT----AKNKWFVCMAKTPEEKHEW 352
           D              N W + +     A  K  V  A T  EK +W
Sbjct: 812 D--------------NEWSVPHCFTIYAAQKTIVVAASTRLEKEKW 843


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 73/265 (27%), Positives = 129/265 (48%), Gaps = 30/265 (11%)

Query: 23  LRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILA 82
           +R C L+E+++TE  Y  TLE +   F+        + + + +T      +F NI +++ 
Sbjct: 192 IRSCCLAEIKQTEEKYTETLESIEKYFM--------APLKRFLTAAEFDSVFINIPELVK 243

Query: 83  VHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT- 141
           +H+  ++ + + +  + +  Q +   F+++K++  IY +YCS  E A   L  ++K +  
Sbjct: 244 LHRNLMQEIHDSIVNKND--QNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKED 301

Query: 142 IRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEAL 201
           ++  L  C       N    L   LV P+QR+ KY L+L+EL+K T    ++ A +  AL
Sbjct: 302 VKLKLEECSKRAN--NGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLAL 358

Query: 202 QAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCG--------VLL 253
            AMK +   +NE KR  E L  ++++Q  IE             +L+ G         + 
Sbjct: 359 DAMKDLAQYVNEVKRDNETLREIKQFQLSIENLN--------QPVLLFGRPQGDGEIRIT 410

Query: 254 KISSGNIQERVFFLFDNLLVYCKRK 278
            +     QER  FLFD  ++ CKRK
Sbjct: 411 TLDKHTKQERHIFLFDLAVIVCKRK 435


>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 84/336 (25%), Positives = 154/336 (45%), Gaps = 37/336 (11%)

Query: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86
           VL  + +TE +Y   L+ ++S +L  +      +  + ++   +  L  N+E+I +  + 
Sbjct: 97  VLQNILETENEYSKELQTVLSTYLRPL------QTSEKLSSANISYLMGNLEEICSFQQM 150

Query: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLELNKIRTIRTF 145
            ++ +EEC    P AQQ VG CFL+   + + +Y  YC+NH  A  +L E ++   +  F
Sbjct: 151 LVQSLEECTKL-PEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSE--ELGEF 207

Query: 146 LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMK 205
           +      G      + L   L  P  R+ KYP +LKEL +     H+D   + +++ A K
Sbjct: 208 MET---KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFK 264

Query: 206 AVCSNINEAKRQME-KLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKIS-SGNIQER 263
            + +   E +++ E +L++L E    I  WEG +I        M  VL++ + S    ER
Sbjct: 265 NLSAQCQEVRKRKELELQILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNER 321

Query: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHI 323
              LF N+L+             AS     ++++G++ T  M +  ++D      S  H 
Sbjct: 322 YLLLFPNVLLML----------SASPRMSGFIYQGKLPTTGMTITKLED------SENH- 364

Query: 324 VVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359
             N ++I  +   +  V      ++  EW E + K+
Sbjct: 365 -RNAFEISGSMIERILV-SCNNQQDLQEWVEHLQKQ 398


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,228,655
Number of Sequences: 37866
Number of extensions: 2683953
Number of successful extensions: 7858
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 7258
Number of HSP's gapped (non-prelim): 444
length of query: 1606
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1490
effective length of database: 13,855,062
effective search space: 20644042380
effective search space used: 20644042380
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.