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Search of human proteins with 47519562
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47519562 reticulon 4 isoform E [Homo sapiens]
(986 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47519562 reticulon 4 isoform E [Homo sapiens] 1901 0.0
gi|24431935 reticulon 4 isoform A [Homo sapiens] 1901 0.0
gi|47519490 reticulon 4 isoform D [Homo sapiens] 364 e-100
gi|24431933 reticulon 4 isoform B [Homo sapiens] 363 e-100
gi|5902016 reticulon 4 isoform C [Homo sapiens] 363 e-100
gi|10863935 reticulon 1 isoform A [Homo sapiens] 271 3e-72
gi|45827778 reticulon 1 isoform B [Homo sapiens] 270 4e-72
gi|45827776 reticulon 1 isoform C [Homo sapiens] 269 8e-72
gi|41393608 reticulon 3 isoform b [Homo sapiens] 257 4e-68
gi|5174655 reticulon 3 isoform a [Homo sapiens] 246 1e-64
gi|41393604 reticulon 3 isoform c [Homo sapiens] 245 1e-64
gi|41393606 reticulon 3 isoform d [Homo sapiens] 209 1e-53
gi|5032055 reticulon 2 isoform A [Homo sapiens] 188 2e-47
gi|46255005 reticulon 2 isoform B [Homo sapiens] 187 4e-47
gi|46255007 reticulon 2 isoform C [Homo sapiens] 187 5e-47
gi|110349719 titin isoform N2-A [Homo sapiens] 50 8e-06
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 50 1e-05
gi|21361116 versican isoform 1 [Homo sapiens] 48 4e-05
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 47 9e-05
gi|62241003 cardiomyopathy associated 5 [Homo sapiens] 47 9e-05
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 46 2e-04
gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens] 44 7e-04
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 43 0.001
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 42 0.002
gi|95147555 microtubule-associated protein 1A [Homo sapiens] 42 0.003
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 42 0.003
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 42 0.003
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 41 0.005
gi|58082089 hypothetical protein LOC161394 [Homo sapiens] 41 0.005
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 40 0.008
>gi|47519562 reticulon 4 isoform E [Homo sapiens]
Length = 986
Score = 1901 bits (4924), Expect = 0.0
Identities = 986/986 (100%), Positives = 986/986 (100%)
Query: 1 MDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQ 60
MDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQ
Sbjct: 1 MDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQ 60
Query: 61 ENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVK 120
ENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVK
Sbjct: 61 ENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVK 120
Query: 121 NKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYAD 180
NKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYAD
Sbjct: 121 NKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYAD 180
Query: 181 FKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTS 240
FKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTS
Sbjct: 181 FKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTS 240
Query: 241 FPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVT 300
FPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVT
Sbjct: 241 FPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVT 300
Query: 301 EKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEV 360
EKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEV
Sbjct: 301 EKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEV 360
Query: 361 TGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPS 420
TGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPS
Sbjct: 361 TGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPS 420
Query: 421 AGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAA 480
AGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAA
Sbjct: 421 AGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAA 480
Query: 481 LQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVD 540
LQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVD
Sbjct: 481 LQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVD 540
Query: 541 LFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLS 600
LFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLS
Sbjct: 541 LFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLS 600
Query: 601 LDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIE 660
LDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIE
Sbjct: 601 LDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIE 660
Query: 661 IIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQP 720
IIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQP
Sbjct: 661 IIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQP 720
Query: 721 KVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTE 780
KVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTE
Sbjct: 721 KVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTE 780
Query: 781 KEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALA 840
KEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALA
Sbjct: 781 KEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALA 840
Query: 841 LLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKEL 900
LLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKEL
Sbjct: 841 LLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKEL 900
Query: 901 RRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYL 960
RRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYL
Sbjct: 901 RRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYL 960
Query: 961 GLANKNVKDAMAKIQAKIPGLKRKAE 986
GLANKNVKDAMAKIQAKIPGLKRKAE
Sbjct: 961 GLANKNVKDAMAKIQAKIPGLKRKAE 986
>gi|24431935 reticulon 4 isoform A [Homo sapiens]
Length = 1192
Score = 1901 bits (4924), Expect = 0.0
Identities = 986/986 (100%), Positives = 986/986 (100%)
Query: 1 MDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQ 60
MDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQ
Sbjct: 207 MDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQ 266
Query: 61 ENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVK 120
ENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVK
Sbjct: 267 ENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVK 326
Query: 121 NKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYAD 180
NKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYAD
Sbjct: 327 NKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYAD 386
Query: 181 FKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTS 240
FKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTS
Sbjct: 387 FKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTS 446
Query: 241 FPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVT 300
FPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVT
Sbjct: 447 FPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVT 506
Query: 301 EKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEV 360
EKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEV
Sbjct: 507 EKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEV 566
Query: 361 TGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPS 420
TGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPS
Sbjct: 567 TGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPS 626
Query: 421 AGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAA 480
AGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAA
Sbjct: 627 AGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAA 686
Query: 481 LQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVD 540
LQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVD
Sbjct: 687 LQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVD 746
Query: 541 LFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLS 600
LFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLS
Sbjct: 747 LFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLS 806
Query: 601 LDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIE 660
LDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIE
Sbjct: 807 LDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIE 866
Query: 661 IIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQP 720
IIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQP
Sbjct: 867 IIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQP 926
Query: 721 KVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTE 780
KVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTE
Sbjct: 927 KVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTE 986
Query: 781 KEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALA 840
KEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALA
Sbjct: 987 KEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALA 1046
Query: 841 LLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKEL 900
LLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKEL
Sbjct: 1047 LLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKEL 1106
Query: 901 RRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYL 960
RRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYL
Sbjct: 1107 RRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYL 1166
Query: 961 GLANKNVKDAMAKIQAKIPGLKRKAE 986
GLANKNVKDAMAKIQAKIPGLKRKAE
Sbjct: 1167 GLANKNVKDAMAKIQAKIPGLKRKAE 1192
>gi|47519490 reticulon 4 isoform D [Homo sapiens]
Length = 392
Score = 364 bits (935), Expect = e-100
Identities = 199/250 (79%), Positives = 210/250 (84%), Gaps = 11/250 (4%)
Query: 746 PPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPS---------AIFSAELSK 796
PP ++++ QAE + P A P+ ++ S S A +
Sbjct: 145 PPPPASVSPQAE--PVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRS 202
Query: 797 TSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 856
++VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ
Sbjct: 203 SAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 262
Query: 857 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 916
AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA
Sbjct: 263 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 322
Query: 917 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 976
VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA
Sbjct: 323 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 382
Query: 977 KIPGLKRKAE 986
KIPGLKRKAE
Sbjct: 383 KIPGLKRKAE 392
>gi|24431933 reticulon 4 isoform B [Homo sapiens]
Length = 373
Score = 363 bits (933), Expect = e-100
Identities = 198/241 (82%), Positives = 206/241 (85%), Gaps = 12/241 (4%)
Query: 746 PPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYW 805
PP ++++ QAE + P A P+ ++ S S VVDLLYW
Sbjct: 145 PPPPASVSPQAE--PVWTPPAPAPAAPPSTPAAPKRRGSSGSV----------VVDLLYW 192
Query: 806 RDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGH 865
RDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGH
Sbjct: 193 RDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGH 252
Query: 866 PFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYV 925
PFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYV
Sbjct: 253 PFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYV 312
Query: 926 GALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKA 985
GALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKA
Sbjct: 313 GALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKA 372
Query: 986 E 986
E
Sbjct: 373 E 373
>gi|5902016 reticulon 4 isoform C [Homo sapiens]
Length = 199
Score = 363 bits (931), Expect = e-100
Identities = 189/191 (98%), Positives = 189/191 (98%)
Query: 796 KTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI 855
K VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI
Sbjct: 9 KDKVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI 68
Query: 856 QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKF 915
QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKF
Sbjct: 69 QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKF 128
Query: 916 AVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQ 975
AVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQ
Sbjct: 129 AVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQ 188
Query: 976 AKIPGLKRKAE 986
AKIPGLKRKAE
Sbjct: 189 AKIPGLKRKAE 199
>gi|10863935 reticulon 1 isoform A [Homo sapiens]
Length = 776
Score = 271 bits (692), Expect = 3e-72
Identities = 219/655 (33%), Positives = 322/655 (49%), Gaps = 83/655 (12%)
Query: 396 ESEATPSPVLPDI--VMEAPLNSA------VPSAGASVIQPSSSPLE---ASSVNY---- 440
E TP P LPD+ + L S+ P+ V + + PL+ A + Y
Sbjct: 141 EELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDIT 200
Query: 441 --ESIKHEPENPPPYEEA--------MSVSLKKVSGIKEEIKEPENINAAL-------QE 483
E +KH+ ++ P E+ +S+K G++E K P + + +
Sbjct: 201 RPEEVKHQEQHHPELEDKDLDFKNKDTDISIKP-EGVREPDK-PAPVEGKIIKDHLLEES 258
Query: 484 TEAPYISIACDLIKETKLSAEPAPDFS------DYSEMAKVEQPVPDHSELVEDSSPDSE 537
T APYI DL +E + + + + S ++ P+ ++ SPD+
Sbjct: 259 TFAPYID---DLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTV 315
Query: 538 PVDLFS---DDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYL 594
P S DDS + T ES + S E ++A+ G Y
Sbjct: 316 PTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISE------DELITAIKEAKGLSYE 369
Query: 595 ESFKLSLDNTKDT-LLPD--EVSTLSKKEKIPLQMEELSTAVYSNDDLF--ISKEAQIRE 649
+ +N + L D EV S IP ++ +++ S D +S++ E
Sbjct: 370 TA-----ENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAE 424
Query: 650 TETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTEL 709
S + P +S + +S L RE + E+ + I + + S +
Sbjct: 425 DALPSGYVSFGHVGGPPPSPASPSIQYSIL-REEREAELDSELIIESCDASSASEESPKR 483
Query: 710 PHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPD--VSALATQAEIESIVKPKVL 767
D ++P + I A S+ L P + +T+ + + P
Sbjct: 484 EQDSP--PMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDG 541
Query: 768 VKEAEKKL----PSDTEKEDRSPSAIFSAE------------LSKTSVVDLLYWRDIKKT 811
E E + P + ++SP+A L+K +DLLYWRDIK+T
Sbjct: 542 ALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQT 601
Query: 812 GVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYL 871
G+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+QA+QK+DEGHPF+AYL
Sbjct: 602 GIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYL 661
Query: 872 ESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNG 931
E E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKFAVLMW+ TYVGALFNG
Sbjct: 662 ELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNG 721
Query: 932 LTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 986
LTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQAKIPG KR AE
Sbjct: 722 LTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 776
Score = 34.3 bits (77), Expect = 0.59
Identities = 80/371 (21%), Positives = 131/371 (35%), Gaps = 84/371 (22%)
Query: 229 EKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATES--------IATNIFPLLGDP 280
+KD + N DT PEG+++ P PA E + P + D
Sbjct: 217 DKDLDFKNKDTDISIKPEGVRE---------PDKPAPVEGKIIKDHLLEESTFAPYIDDL 267
Query: 281 TSENK-----TDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEE 335
+ E + T KI + + E T KT + + S D V T +++ ++
Sbjct: 268 SEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPS-PDTVPTVTVSEPEDD 326
Query: 336 VVANM---PEGLTPDLVQEACESELNE---VTGTK----IAYETKMD------LVQTSEV 379
++ G P + + ++E +T K ++YET + L EV
Sbjct: 327 SPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEV 386
Query: 380 MQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPL--NSAVPSAGAS---VIQPSSSP-- 432
S P E S A ++V E P+ A+PS S V P SP
Sbjct: 387 KARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPAS 446
Query: 433 ------------------------LEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIK 468
+ASS + ES K E ++PP A+ ++++ +G++
Sbjct: 447 PSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALD-AIREETGVR 505
Query: 469 EEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQP-VPDHSE 527
E + P A + Y S +P P+ + E P +P E
Sbjct: 506 AEERAPSRRGLAEPGSFLDYPS----------TEPQPGPELPPGDGALEPETPMLPRKPE 555
Query: 528 LVEDSSPDSEP 538
EDSS + P
Sbjct: 556 --EDSSSNQSP 564
>gi|45827778 reticulon 1 isoform B [Homo sapiens]
Length = 356
Score = 270 bits (691), Expect = 4e-72
Identities = 130/193 (67%), Positives = 162/193 (83%)
Query: 794 LSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKG 853
L+K +DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK
Sbjct: 164 LNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKS 223
Query: 854 VIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSL 913
V+QA+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSL
Sbjct: 224 VLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSL 283
Query: 914 KFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAK 973
KFAVLMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AK
Sbjct: 284 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAK 343
Query: 974 IQAKIPGLKRKAE 986
IQAKIPG KR AE
Sbjct: 344 IQAKIPGAKRHAE 356
>gi|45827776 reticulon 1 isoform C [Homo sapiens]
Length = 208
Score = 269 bits (688), Expect = 8e-72
Identities = 129/191 (67%), Positives = 161/191 (84%)
Query: 796 KTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI 855
K+ +DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+
Sbjct: 18 KSQAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL 77
Query: 856 QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKF 915
QA+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKF
Sbjct: 78 QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF 137
Query: 916 AVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQ 975
AVLMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQ
Sbjct: 138 AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ 197
Query: 976 AKIPGLKRKAE 986
AKIPG KR AE
Sbjct: 198 AKIPGAKRHAE 208
>gi|41393608 reticulon 3 isoform b [Homo sapiens]
Length = 1013
Score = 257 bits (656), Expect = 4e-68
Identities = 276/1056 (26%), Positives = 461/1056 (43%), Gaps = 149/1056 (14%)
Query: 7 PGNTISAGQEDFPSVLLETAASLPSLSPLS---AASFKEHEYLGNLS-TVLPTEGTLQEN 62
PG + G + S E +SL S P S +SF + N T+L E + +
Sbjct: 31 PGACPALGTKSCSSSCAEGLSSLCSDEPSSEIMTSSFLSSSEIHNTGLTILHGE---KSH 87
Query: 63 VSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNK 122
V + ++++ K L DL + ++E + G+S +VS + S + I +
Sbjct: 88 VLGSQPILAKEGKDHL---DLLDMKKMEKPQ-GTSNNVSDSSVSLAAGVHCDRPSIPASF 143
Query: 123 DEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFK 182
E +S I ++++ K K VSS +AK + + ++ ++
Sbjct: 144 PEHPAFLSKKIGQVEEQID----KETKNPNGVSSREAKTALDADDRFTLLTAQKPPTEYS 199
Query: 183 PFERVW--EVKDSKEDSDMLAAGGKIESNLESKVDK----KCFADSLEQTNHE------- 229
E ++ + SK D + ES E +DK K F DS +++ +
Sbjct: 200 KVEGIYTYSLSPSKVSGDDVIEKDSPESPFEVIIDKAAFDKEFKDSYKESTDDFGSWSVH 259
Query: 230 KDSESSND-----DTSFPSTPE--------GIKDRSGAYITCA---------PFNPAATE 267
D ESS D D FP + + R ++ A + E
Sbjct: 260 TDKESSEDISETNDKLFPLRNKEAGRYPMSALLSRQFSHTNAALEEVSRCVNDMHNFTNE 319
Query: 268 SIATNIFPLLGDPTSEN-----KTDEKKIEEKKAQI-VTEKNTSTKTSNPFLVAAQDSET 321
+ ++ P + T ++ KT + E ++I V TST P V + D T
Sbjct: 320 ILTWDLVPQVKQQTDKSSDCITKTTGLDMSEYNSEIPVVNLKTSTHQKTP--VCSIDGST 377
Query: 322 DYV-TTDNLTKVT---EEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTS 377
+T + + + E + P PD + E + V G ++ +
Sbjct: 378 PITKSTGDWAEASLQQENAITGKP---VPDSLNSTKEFSIKGVQG---------NMQKQD 425
Query: 378 EVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLE--- 434
+ + E + C S AT VLPD ++ ++ + G SS +
Sbjct: 426 DTLAELPGSPPEKCDSLGSGVATVKVVLPDDHLKDEMDWQSSALGEITEADSSGESDDTV 485
Query: 435 ----ASSVNYESIKHEPENPPPYEEAMSVS----LKKVSGIKEEIKEPENINAALQETE- 485
+ ++E+ K + E P A+ + +K++ + E K +N + ++E
Sbjct: 486 IEDITADTSFENNKIQAEKPVSIPSAVVKTGEREIKEIPSCEREEKTSKNFEELVSDSEL 545
Query: 486 ----------APYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPD 535
+P AC + +T +S E D SE+A + ++ +L SP+
Sbjct: 546 HQDQPDILGRSPASEAACSKVPDTNVSLE------DVSEVAPEKPITTENPKLPSTVSPN 599
Query: 536 SEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLE 595
+F++ + T ESL + + + + ++ ++A K ++
Sbjct: 600 -----VFNETEF-----SLNVTTSAYLESLHGKNVKHIDDSSPEDLIAAFTETRDKGIVD 649
Query: 596 S----FKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETE 651
S FK + D V L + E +++++ + YS Q +ET
Sbjct: 650 SERNAFKAISEKMTDFKTTPPVEVLHENESGGSEIKDIGSK-YSE---------QSKET- 698
Query: 652 TFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPH 711
+ S P+ + FPT + + L E L + E+ T
Sbjct: 699 --NGSEPLGV---FPT----QGTPVASLDLEQEQLTIKALKELGERQVEKS----TSAQR 745
Query: 712 DLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEA 771
D L + EE + + F+ +L +V +++ KP + +
Sbjct: 746 DAELPS-----EEVLKQTFTFAPESWPQRSYDILERNVK---NGSDLGISQKPITIRETT 797
Query: 772 EKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIV 831
S K + + + L+ SV DL++WRD+KKTG VFG +L +LLSL FS++
Sbjct: 798 RVDAVSSLSKTELVKKHVLARLLTDFSVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVI 857
Query: 832 SVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALG 891
SV +Y+ LALLSVTISFRIYK VIQA+QKS+EGHPF+AYL+ ++ +S E Y N+A+
Sbjct: 858 SVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMV 917
Query: 892 HVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYER 951
H+N +K + RLFLV+DLVDSLK AV MW+ TYVGA+FNG+TLLILA + +FSVP++YE+
Sbjct: 918 HINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEK 977
Query: 952 HQAQIDHYLGLANKNVKDAMAKIQAKIPGL-KRKAE 986
++ QIDHY+G+A K + KIQAK+PG+ K+KAE
Sbjct: 978 YKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 1013
>gi|5174655 reticulon 3 isoform a [Homo sapiens]
Length = 236
Score = 246 bits (627), Expect = 1e-64
Identities = 120/217 (55%), Positives = 161/217 (74%), Gaps = 1/217 (0%)
Query: 771 AEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSI 830
AE P P+ + S +V DL++WRD+KKTG VFG +L +LLSL FS+
Sbjct: 20 AEPSAPGGGGSPGACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSV 79
Query: 831 VSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSAL 890
+SV +Y+ LALLSVTISFRIYK VIQA+QKS+EGHPF+AYL+ ++ +S E Y N+A+
Sbjct: 80 ISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAM 139
Query: 891 GHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYE 950
H+N +K + RLFLV+DLVDSLK AV MW+ TYVGA+FNG+TLLILA + +FSVP++YE
Sbjct: 140 VHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYE 199
Query: 951 RHQAQIDHYLGLANKNVKDAMAKIQAKIPGL-KRKAE 986
+++ QIDHY+G+A K + KIQAK+PG+ K+KAE
Sbjct: 200 KYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 236
>gi|41393604 reticulon 3 isoform c [Homo sapiens]
Length = 255
Score = 245 bits (626), Expect = 1e-64
Identities = 116/193 (60%), Positives = 155/193 (80%), Gaps = 1/193 (0%)
Query: 795 SKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGV 854
S + V DL++WRD+KKTG VFG +L +LLSL FS++SV +Y+ LALLSVTISFRIYK V
Sbjct: 63 STSQVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSV 122
Query: 855 IQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLK 914
IQA+QKS+EGHPF+AYL+ ++ +S E Y N+A+ H+N +K + RLFLV+DLVDSLK
Sbjct: 123 IQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLK 182
Query: 915 FAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKI 974
AV MW+ TYVGA+FNG+TLLILA + +FSVP++YE+++ QIDHY+G+A K + KI
Sbjct: 183 LAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKI 242
Query: 975 QAKIPGL-KRKAE 986
QAK+PG+ K+KAE
Sbjct: 243 QAKLPGIAKKKAE 255
>gi|41393606 reticulon 3 isoform d [Homo sapiens]
Length = 241
Score = 209 bits (532), Expect = 1e-53
Identities = 101/183 (55%), Positives = 136/183 (74%)
Query: 771 AEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSI 830
AE P P+ + S +V DL++WRD+KKTG VFG +L +LLSL FS+
Sbjct: 20 AEPSAPGGGGSPGACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSV 79
Query: 831 VSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSAL 890
+SV +Y+ LALLSVTISFRIYK VIQA+QKS+EGHPF+AYL+ ++ +S E Y N+A+
Sbjct: 80 ISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAM 139
Query: 891 GHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYE 950
H+N +K + RLFLV+DLVDSLK AV MW+ TYVGA+FNG+TLLILA + +FSVP++YE
Sbjct: 140 VHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYE 199
Query: 951 RHQ 953
+++
Sbjct: 200 KYK 202
>gi|5032055 reticulon 2 isoform A [Homo sapiens]
Length = 545
Score = 188 bits (478), Expect = 2e-47
Identities = 94/195 (48%), Positives = 134/195 (68%), Gaps = 1/195 (0%)
Query: 786 PSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT 845
PS A++ + V DLLYW+D + +GVVF + LL L FSIVSV A++AL LL T
Sbjct: 333 PSLSLGADMG-SKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGT 391
Query: 846 ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFL 905
IS R+Y+ V+QA+ + D +PF+AYL+ ++ ++ E ++ S+ V +LR FL
Sbjct: 392 ISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFL 451
Query: 906 VDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANK 965
V+DLVDSLK A+L ++ T+VGA+FNGLTLLIL +I LF++P++Y +HQAQID Y+GL
Sbjct: 452 VEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTN 511
Query: 966 NVKDAMAKIQAKIPG 980
+ AKI+AKIPG
Sbjct: 512 QLSHIKAKIRAKIPG 526
>gi|46255005 reticulon 2 isoform B [Homo sapiens]
Length = 472
Score = 187 bits (475), Expect = 4e-47
Identities = 100/224 (44%), Positives = 144/224 (64%), Gaps = 8/224 (3%)
Query: 764 PKVLVKEAEKKLPSDTEKE-------DRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFG 816
P+ + E E+K E+E D + F+ E + V DLLYW+D + +GVVF
Sbjct: 231 PEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVE-PRLLVADLLYWKDTRTSGVVFT 289
Query: 817 ASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVA 876
+ LL L FSIVSV A++AL LL TIS R+Y+ V+QA+ + D +PF+AYL+ ++
Sbjct: 290 GLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLT 349
Query: 877 ISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLI 936
++ E ++ S+ V +LR FLV+DLVDSLK A+L ++ T+VGA+FNGLTLLI
Sbjct: 350 LTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLI 409
Query: 937 LALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPG 980
L +I LF++P++Y +HQAQID Y+GL + AKI+AKIPG
Sbjct: 410 LGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPG 453
>gi|46255007 reticulon 2 isoform C [Homo sapiens]
Length = 205
Score = 187 bits (474), Expect = 5e-47
Identities = 91/184 (49%), Positives = 129/184 (70%)
Query: 797 TSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 856
+ V DLLYW+D + +GVVF + LL L FSIVSV A++AL LL TIS R+Y+ V+Q
Sbjct: 3 SKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQ 62
Query: 857 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 916
A+ + D +PF+AYL+ ++ ++ E ++ S+ V +LR FLV+DLVDSLK A
Sbjct: 63 AVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLA 122
Query: 917 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 976
+L ++ T+VGA+FNGLTLLIL +I LF++P++Y +HQAQID Y+GL + AKI+A
Sbjct: 123 LLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRA 182
Query: 977 KIPG 980
KIPG
Sbjct: 183 KIPG 186
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 50.4 bits (119), Expect = 8e-06
Identities = 156/787 (19%), Positives = 291/787 (36%), Gaps = 146/787 (18%)
Query: 52 VLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVA 111
V+ E L V+E +++++ K L+ + E V + + AV
Sbjct: 9625 VIKMEEPLPAKVTERHMQITQEEKVLVA---------VTKKEAPPKARVPEEPKRAV--- 9672
Query: 112 NPREEII-VKNKDEEEKLVS-----NNILHNQQ---ELPTALTKLVKEDEVVSSEKAKDS 162
P E+++ +K K EEE ++ ++ E P + +KE ++ ++ +
Sbjct: 9673 -PEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYT 9731
Query: 163 FNEKRVAVEAPMREEYADFKPFE-RVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFAD 221
E+ V+V+ EEY +++ ++ + +E + E+ D +
Sbjct: 9732 LEEEAVSVQR--EEEYEEYEEYDYKEFEEYEPTEEYDQY--------------------E 9769
Query: 222 SLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAAT--------ESIATNI 273
E+ +E+ E T P P +K + P P A E + I
Sbjct: 9770 EYEEREYERYEEHEEYITE-PEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPI 9828
Query: 274 FPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVT 333
L P + + KK+ E+K +I K + + P A + V + V
Sbjct: 9829 PKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEP--AAKVPMKPKRVVAEEKVPVP 9886
Query: 334 EEVVA------NMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSE-VMQESLYP 386
+ VA +P+ L P+ V A E E+ + E + + + E + +E + P
Sbjct: 9887 RKEVAPPVRVPEVPKELEPEEV--AFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVP 9944
Query: 387 AAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHE 446
+ + P +P+ P+ + A V + P E V + +
Sbjct: 9945 VIPV-----KVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPV----LIPK 9995
Query: 447 PENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPA 506
E PPP + V K V K + P+ + A A + + E K+ PA
Sbjct: 9996 KEKPPP-AKVPEVPKKPVPEEKVPVPVPKKVEAP----PAKVPEVPKKPVPEKKVPV-PA 10049
Query: 507 PDFSDYSEMAKVEQPVPDHSELVEDSSPDSE---PVDLFSDDSIPDVPQKQDET---VML 560
P KVE P E+ + P+ + PV + P VP+K++ V L
Sbjct: 10050 PK--------KVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVAL 10101
Query: 561 VKESLTETSFESMIEYENK---EKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLS 617
+E E FE I E + E+ LP E + +LP+E L
Sbjct: 10102 PQEE--EVLFEEEIVPEEEVLPEEEEVLPEE-----------------EEVLPEEEEVLP 10142
Query: 618 KKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFS 677
++E+IP + EE V ++ +E + E E + P + +
Sbjct: 10143 EEEEIPPEEEE----VPPEEEYVPEEEEFVPEEEVLPEVKP-------KVPVPAPVPEIK 10191
Query: 678 KLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKN-IQPKVEE--KISFSDDFSK 734
K +V+ K + + A E+P + K I PK EE + +++ +
Sbjct: 10192 K--------KVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEE 10243
Query: 735 NGSATSKVLLLPPDVSALATQAEIESIVKPKV--LVKEAEKKLPSDTEKEDRSPSAIFSA 792
+ ++ PP + E+E + P+V ++K+A + P+ K+ +P A S
Sbjct: 10244 EPISEEEIPEEPPSIE------EVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSK 10297
Query: 793 ELSKTSV 799
++ + V
Sbjct: 10298 KIPEEKV 10304
Score = 48.9 bits (115), Expect = 2e-05
Identities = 143/718 (19%), Positives = 274/718 (38%), Gaps = 88/718 (12%)
Query: 102 PKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKD 161
P + +I A E I V +K EE K+++ T ++ KE E V EK +
Sbjct: 9013 PPPPTTLIPAKAPEIIDVSSKAEEVKIMTI----------TRKKEVQKEKEAVY-EKKQA 9061
Query: 162 SFNEKRVAVEAPMREEYADFK------PFERVWEVKDSKEDSDMLAAGGKIESNLESKVD 215
EKRV +E+ E Y + + PFE+ + ++ ED + + K E + E + D
Sbjct: 9062 VHKEKRVFIES-FEEPYDELEVEPYTEPFEQPY-YEEPDEDYEEIKVEAKKEVHEEWEED 9119
Query: 216 KKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFP 275
F + E E+ + ++ E ++R + + + + +
Sbjct: 9120 ---FEEGQEYYEREEGYDEGEEEWE-----EAYQEREVIQVQKEVYEESHERKVPAKVPE 9171
Query: 276 LLGDPTSE--NKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVT 333
P + K +KIE+ ++ EK TK + S+ + T V
Sbjct: 9172 KKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVP-------EVSKKIVPQKPSRTPVQ 9224
Query: 334 EEVV-ANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAA--QL 390
EEV+ +P T +V E ++ + T+ + VQ V +E ++ A ++
Sbjct: 9225 EEVIEVKVPAVHTKKMV--ISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRV 9282
Query: 391 CPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENP 450
P + E P P+ V P+ V V + P+ K EP P
Sbjct: 9283 EPPPKVPELPEKPA-PEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAP 9341
Query: 451 PPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIA-CDLIKETKLSAEPAPDF 509
P E + + K+ E A + E + ++ ++ + + S PA
Sbjct: 9342 PKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPE 9401
Query: 510 SDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKES---LT 566
++ + +PVP E V P V +P+ +K V + K++
Sbjct: 9402 IPKKKVPEERKPVPRKEEEV----PPPPKVPALPKKPVPE--EKVAVPVPVAKKAPPPRA 9455
Query: 567 ETSFESMIEYEN---KEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIP 623
E S ++++E + +EKLS P+ ++ T+ + +E + S++E
Sbjct: 9456 EVSKKTVVEEKRFVAEEKLSFAVPQ-----------RVEVTRHEVSAEEEWSYSEEE--- 9501
Query: 624 LQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREY 683
E +S +VY ++ +EA++ E E + +++E +IS + ++ E
Sbjct: 9502 ---EGVSISVYREEEREEEEEAEVTEYEVMEEPEEY-VVEEKLHIISKRVEAEPAEVTER 9557
Query: 684 TDLEVSHKSEI---------ANAPDGAGSL-PCTELPHDLSLKNI--QPKVEEKISFSDD 731
+ ++ K +I A P+ + P ++P + K PKV E+
Sbjct: 9558 QEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVP 9617
Query: 732 FSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAI 789
K KV+ + + A T+ ++ + KVLV +K+ P + A+
Sbjct: 9618 EKK---VPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAV 9672
Score = 47.8 bits (112), Expect = 5e-05
Identities = 147/738 (19%), Positives = 266/738 (36%), Gaps = 76/738 (10%)
Query: 102 PKAESAVIV--ANPREEIIV----KNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVS 155
PKA A ++ A P E++ V K K K+ ++++ ++TK +E E V+
Sbjct: 9807 PKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITK--REKEQVT 9864
Query: 156 SEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVD 215
AK KRV E + + P RV EV E ++ E + + V+
Sbjct: 9865 EPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVA-----FEEEVVTHVE 9919
Query: 216 KKCFADSLEQTNHEKDSESSND-----DTSFPSTPEG----------IKDRSGAYITCAP 260
+ + E + E++ + + P P + + A P
Sbjct: 9920 EYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVP 9979
Query: 261 FNPAATESIATNIFPLLGDPTSEN--KTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQD 318
P E + P P + +K + E+K + K + V +
Sbjct: 9980 EVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKP 10039
Query: 319 SETDYVTTDNLTKV------TEEVVANM-PEGLTPDLVQEACESELNEVTGTKIAYETKM 371
V KV EV + PE P V + E+ +V + +
Sbjct: 10040 VPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPV 10099
Query: 372 DLVQTSEVM-QESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVI-QPS 429
L Q EV+ +E + P ++ P EE VLP+ P +P V +
Sbjct: 10100 ALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEE 10159
Query: 430 SSPLEASSVNYESIKHE-----PENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQET 484
P E V E + E P P E V+ KKV K+E P + ++
Sbjct: 10160 YVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKV 10219
Query: 485 EAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPV-PDHSELVEDSSPDSEPVDLFS 543
E I + KE ++ + + +++ E P P E VE+ +P P +
Sbjct: 10220 EEKRIILP----KEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVI-- 10273
Query: 544 DDSIPD----VPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKL 599
++P+ VP+K + V + + E + + KE A PE K E L
Sbjct: 10274 KKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVP--VPVQKKEAPPAKVPEVPKKVPEKKVL 10331
Query: 600 -----SLDNTKD-TLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETF 653
++ K T+L ++VS ++E + + EL ++ I +E + E E +
Sbjct: 10332 VPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEE--IPEEEEFHEVEEY 10389
Query: 654 SDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEI-----ANAPDGAGSLPCTE 708
+ ++EF L + + ++ + + +EV E+ AP +
Sbjct: 10390 FEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKI 10449
Query: 709 LPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLV 768
+P + P+ E + K + + +P + T ++ ++ PK +V
Sbjct: 10450 IPPKKPPTKVVPRKEPPAKVPEVPKK--IVVEEKVRVPEEPRVPPT--KVPEVLPPKEVV 10505
Query: 769 KEAEKKLPSDTEKEDRSP 786
EKK+P K+ +P
Sbjct: 10506 --PEKKVPVPPAKKPEAP 10521
Score = 31.6 bits (70), Expect = 3.8
Identities = 98/474 (20%), Positives = 173/474 (36%), Gaps = 85/474 (17%)
Query: 333 TEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKM-DLVQTSEVMQESLYPAAQLC 391
T+ V P P++ ++ E V TK+ +++ EV+ E P
Sbjct: 10457 TKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPV---- 10512
Query: 392 PSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNY---------ES 442
P ++ EA P P +P+ E VP +P P + V E+
Sbjct: 10513 PPAKKPEAPP-PKVPEAPKEVVPEKKVPVPPPK--KPEVPPTKVPEVPKAAVPEKKVPEA 10569
Query: 443 IKHEPENPPP-YEEAMS--VSLKKVSGIKEE------IKEPENINAALQETEAPYISIAC 493
I +PE+PPP EA V KKV + +K PE + E + P
Sbjct: 10570 IPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVP------ 10623
Query: 494 DLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQK 553
+ K P + ++A E+ VP+ P+S P ++F + P+
Sbjct: 10624 --VPPPKKPEVPPTKVPEVPKVAVPEKKVPE----AIPPKPESPPPEVFEE---PEEVAL 10674
Query: 554 QDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEV 613
++ +V+E E + + K+ + PE P + + K L K +P EV
Sbjct: 10675 EEPPAEVVEE--PEPAAPPQVTVPPKKPV----PEKKAPAVVAKKPELPPVKVPEVPKEV 10728
Query: 614 STLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKT 673
++K+PL + + A A++ E P E++ E + K
Sbjct: 10729 ---VPEKKVPLVVPKKPEA----------PPAKVPEV-------PKEVVPEKKVAVPKKP 10768
Query: 674 DSFSKLAREYTDLEVSHKSEIANAPDGAGSLP--CTELPHDLS-LKNIQPKVEEKISFSD 730
+ E V + P+ A S P E P +++ + I P+ E+ + ++
Sbjct: 10769 EVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAE 10828
Query: 731 DFSKNGSATSKVLLLPPDVSALATQAEIESIVKPK--VLVKEAEKKLPSDTEKE 782
+ P+V A E + I+ K ++K+ E P + E E
Sbjct: 10829 EEE-------------PEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPE 10869
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 50.1 bits (118), Expect = 1e-05
Identities = 111/544 (20%), Positives = 213/544 (39%), Gaps = 65/544 (11%)
Query: 140 LPTALTKLVKED---EVVSSEKAK--DSFNEKRVAVEAPMREEYADFKPFERVWEVKDSK 194
LP L K+ +V S EK K + ++ V VE E + E E K++K
Sbjct: 422 LPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE--EEKEAK 479
Query: 195 EDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESS-NDDTSFPS---TPEGIKD 250
E+ GG+ E E ++ + E + EK+++S ++ P+ +PE +
Sbjct: 480 EEEGKEEEGGE-EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 251 RSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSN 310
+S A + +P +S A +++ + K E+++A+ E + K +
Sbjct: 539 KSPAEVK----SPEKAKSPAKE--------EAKSPPEAKSPEKEEAKSPAEVKSPEKAKS 586
Query: 311 PFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETK 370
P A+ S + + + +E + E +P V+E +S + K TK
Sbjct: 587 PAKEEAK-SPAEAKSPEKAKSPVKEEAKSPAEAKSP--VKEEAKSPAEVKSPEKAKSPTK 643
Query: 371 MDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSS 430
+E+ P P EE+++ P + EA + A + V +
Sbjct: 644 ----------EEAKSPEKAKSPEKEEAKS-PEKAKSPVKAEA---KSPEKAKSPVKAEAK 689
Query: 431 SPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQE------- 483
SP +A S E K + P +E K S +KEE K PE + ++E
Sbjct: 690 SPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK 749
Query: 484 TEAPYISIACDL---------IKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSP 534
++P + D+ +E + A+ P+ + +V+ P S L ED+
Sbjct: 750 AKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKA 809
Query: 535 DSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFE------SMIEYENKEKLSALPPE 588
+ + + P V +++ + VKE + E E ++ +K A E
Sbjct: 810 PEKEIPKKEEVKSP-VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE 868
Query: 589 GGKPYLESFK-LSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQI 647
KP +E K +++ K++ + + K+K+P +E V +D ++ ++
Sbjct: 869 APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928
Query: 648 RETE 651
+ E
Sbjct: 929 AKKE 932
>gi|21361116 versican isoform 1 [Homo sapiens]
Length = 3396
Score = 48.1 bits (113), Expect = 4e-05
Identities = 142/697 (20%), Positives = 260/697 (37%), Gaps = 125/697 (17%)
Query: 55 TEGTLQENVSEASKEVSEKAKTLLIDRDL---TEFSELEYSEMGSSFSVSPKAESAVIVA 111
+E +QE S S + S + + D TE +YS + + + S E
Sbjct: 2116 SEEQIQEEKSFESPQNSPATEQTIFDSQTFTETELKTTDYSVLTTKKTYSDDKEM----- 2170
Query: 112 NPREEIIVKNKDEEEKLVSN-------NILHNQQELPTALTKLVKEDEVVSSEKAKDSFN 164
K+E+ LV+ N L + LP A K +++ +S
Sbjct: 2171 ----------KEEDTSLVNMSTPDPDANGLESYTTLPEATEK---SHFFLATALVTESIP 2217
Query: 165 EKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAG-GKIESNLESKVDKKCFADSL 223
+ V ++P+++E + K F + + D+++L +G G E L + + +
Sbjct: 2218 AEHVVTDSPIKKEEST-KHFPKGMRPTIQESDTELLFSGLGSGEEVLPTLPTESVNFTEV 2276
Query: 224 EQTN-----HEKDSES-SNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLL 277
EQ N H ES S+D + E + G ++ + +T + +L
Sbjct: 2277 EQINNTLYPHTSQVESTSSDKIEDFNRMENVAKEVGPLVSQTDIFEGSGSVTSTTLIEIL 2336
Query: 278 GDPTSENKTDE-------------------KKIEEKKAQIVTEKNTSTKTSNPFLVAAQD 318
D +E T ++I+ + Q +TE++++ +S +
Sbjct: 2337 SDTGAEGPTVAPLPFSTDIGHPQNQTVRWAEEIQTSRPQTITEQDSNKNSSTAEINETTT 2396
Query: 319 SETDYVTTDNLTKVTEEVVANMPEGLTPDLVQE-----ACESELNEVTGTKIAYETKMDL 373
S TD++ ++ +E V + P+ DL E + E ++ + T +
Sbjct: 2397 SSTDFLARAYGFEMAKEFVTSAPK--PSDLYYEPSGEGSGEVDIVDSFHTSATTQATRQE 2454
Query: 374 VQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPL 433
T+ V SL + P ++A + P + + PL+S Q SSP
Sbjct: 2455 SSTTFVSDGSL----EKHPEVPSAKAVTADGFPTVSVMLPLHSE---------QNKSSPD 2501
Query: 434 EASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEP-ENINAALQETEAPYISIA 492
S+++ ++ +E +++ + S +K K+P ENI L + + I
Sbjct: 2502 PTSTLS-NTVSYERSTDGSFQDRFREF--EDSTLKPNRKKPTENIIIDLDKEDKDLI--- 2555
Query: 493 CDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVE-----DSSPDSEPVDLFSDDSI 547
+ + T L P SD + + ++ P + +++ D+ SEP D +D+S
Sbjct: 2556 LTITESTILEILPELT-SDKNTIIDIDHTKPVYEDILGMQTDIDTEVPSEPHD-SNDESN 2613
Query: 548 PDVPQKQDETVMLVKESLTETSFESMIE---------------YENKEKLSALPPEGGKP 592
D Q Q+ V SLTE +FE + YE++ +L + G
Sbjct: 2614 DDSTQVQEIYEAAVNLSLTEETFEGSADVLASYTQATHDESMTYEDRSQLDHM----GFH 2669
Query: 593 YLESFKL-SLDNTKDTLLPDEVS--TLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRE 649
+ S + D LLP S K + ++E + + DD+F E
Sbjct: 2670 FTTGIPAPSTETELDVLLPTATSLPIPRKSATVIPEIEGIKAEAKALDDMF--------E 2721
Query: 650 TETFSDSSPIEIIDE-FPTLISSKTDSFSKLAREYTD 685
+ T SD I E PTL F + EY D
Sbjct: 2722 SSTLSDGQAIADQSEIIPTL-----GQFERTQEEYED 2753
Score = 36.6 bits (83), Expect = 0.12
Identities = 58/282 (20%), Positives = 112/282 (39%), Gaps = 47/282 (16%)
Query: 513 SEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVP---------QKQDETVMLVKE 563
S+++ + P+ S+ E S +++PV + +P+ P +++E
Sbjct: 1338 SDLSVIGHPIDSESKEDEPCSEETDPVHDLMAEILPEFPDIIEIDLYHSEENEEEEEECA 1397
Query: 564 SLTETSFESMIEYENKEKLSALPP------EGGKPYLESFKLSLDNTKDTLLPDEVSTLS 617
+ T+ + ++Y N + L P E + ES S N D S+ S
Sbjct: 1398 NATDVTTTPSVQYINGKHLVTTVPKDPEAAEARRGQFESVAPS-QNFSD-------SSES 1449
Query: 618 KKEKIPLQMEELSTAVYSNDDLFISKEAQI--------RETETFSDSSPIEIIDEFPTL- 668
+ ELSTAV N+ ++ ++ +E FS P D FPT+
Sbjct: 1450 DTHPFVIAKTELSTAVQPNESTETTESLEVTWKPETYPETSEHFSGGEP----DVFPTVP 1505
Query: 669 --ISSKTDSFSKLAREYT--DLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKV-- 722
++ + K A T D EV H++ P SL E ++++ K+
Sbjct: 1506 FHEEFESGTAKKGAESVTERDTEVGHQAHEHTEP---VSLFPEESSGEIAIDQESQKIAF 1562
Query: 723 --EEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIV 762
+++F ++ K+ S T ++P SA ++ E +++
Sbjct: 1563 ARATEVTFGEEVEKSTSVTYTPTIVPSSASAYVSEEEAVTLI 1604
Score = 34.3 bits (77), Expect = 0.59
Identities = 109/521 (20%), Positives = 186/521 (35%), Gaps = 98/521 (18%)
Query: 194 KEDSDMLAAGGKIESNLESKVDKKCFADSLEQTN-----HEKDSESSNDDTSF------- 241
+E S + G +E + E K AD + H + ++SS D TS
Sbjct: 2453 QESSTTFVSDGSLEKHPEVPSAKAVTADGFPTVSVMLPLHSEQNKSSPDPTSTLSNTVSY 2512
Query: 242 -PSTPEGIKDRSGAY--ITCAPFNPAATESIA----------------TNIFPLLGDPTS 282
ST +DR + T P TE+I + I +L + TS
Sbjct: 2513 ERSTDGSFQDRFREFEDSTLKPNRKKPTENIIIDLDKEDKDLILTITESTILEILPELTS 2572
Query: 283 ENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPE 342
+ T I+ + V E +T V ++ +++ + D+ T+V E A +
Sbjct: 2573 DKNTI---IDIDHTKPVYEDILGMQTDIDTEVPSEPHDSNDESNDDSTQVQEIYEAAVNL 2629
Query: 343 GLTPDLVQEACESELNEVTGT---KIAYETKMDL------------VQTSEVMQESLYPA 387
LT + + + + + T + YE + L ++E + L P
Sbjct: 2630 SLTEETFEGSADVLASYTQATHDESMTYEDRSQLDHMGFHFTTGIPAPSTETELDVLLPT 2689
Query: 388 AQLCPSFEESEATPSPVLPDIVMEAP----------LNSAVPSAGASVIQPSSSPLEASS 437
A P +S AT P + I EA L+ A S I P+ E +
Sbjct: 2690 ATSLPIPRKS-ATVIPEIEGIKAEAKALDDMFESSTLSDGQAIADQSEIIPTLGQFERTQ 2748
Query: 438 VNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIK 497
YE KH P ++ S SG +E + + PY+SIA +
Sbjct: 2749 EEYEDKKHA---GPSFQPEFS------SGAEEALVD-----------HTPYLSIATTHLM 2788
Query: 498 ETKLSAEP-------APDFSD----YSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDS 546
+ ++ P P ++D S AK+ P + S S ++ +
Sbjct: 2789 DQSVTEVPDVMEGSNPPYYTDTTLAVSTFAKLSSQTPSSPLTIYSGSEASGHTEIPQPSA 2848
Query: 547 IPDVPQKQDETVMLVKESLTE--TSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNT 604
+P + +VM ++S E + E+ + ++E L P P + + S D+
Sbjct: 2849 LPGI--DVGSSVMSPQDSFKEIHVNIEATFKPSSEEYLHITEPPSLSPDTK-LEPSEDDG 2905
Query: 605 KDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEA 645
K LL E S E I ++ E+ + D +S EA
Sbjct: 2906 KPELL--EEMEASPTELIAVEGTEILQDFQNKTDGQVSGEA 2944
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 47.0 bits (110), Expect = 9e-05
Identities = 67/288 (23%), Positives = 114/288 (39%), Gaps = 42/288 (14%)
Query: 369 TKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQP 428
T+ ++++ E ++ + L + + P+PV+ ++ +S ++P
Sbjct: 494 TQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSR------ESLKP 547
Query: 429 SSSPLEASSVNYESIKHEP--------ENPPPYEEAMSVSLKKVSGIKEEIK-------- 472
++ PL + SV ES + P E PP E V +KK IK E K
Sbjct: 548 AAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEV 607
Query: 473 ----EPENINAALQETEA----PYISIACDLIKETKLSAEPAPDFSD--YSEMAKVEQPV 522
EP + A + E +A P + + KETK+ E + + E+AK E
Sbjct: 608 PSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKT 667
Query: 523 PDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKL 582
P + ++ P E V I K++E KE ET + + + KE+
Sbjct: 668 P----IKKEEKPKKEEVKKEVKKEI-----KKEEKKEPKKEVKKETPPKEVKKEVKKEEK 718
Query: 583 SALPPEGGKPYLESFKLSLDNTK-DTLLPDEVSTLSKKEKIPLQMEEL 629
+ E +P E KL D K T L + + K K+P + E +
Sbjct: 719 KEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766
Score = 33.1 bits (74), Expect = 1.3
Identities = 113/587 (19%), Positives = 217/587 (36%), Gaps = 112/587 (19%)
Query: 127 KLVSNNILHNQQELPTALTKLVKED----------EVVSSEKAKDSFNEKRVAVEAPMRE 176
++ S ++ ++QE + +KED E +SS+ A + +E+++ +P +
Sbjct: 1447 EMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPAL-ALDERKLGDVSPTQI 1505
Query: 177 EYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSN 236
+ + F F KED+ M + G + + VD+ D+ +++
Sbjct: 1506 DVSQFGSF---------KEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTAS 1556
Query: 237 DDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEK-- 294
TS S PE D + +P +TE + ++ PT+ +T+ +E+
Sbjct: 1557 VATS--SFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECP 1614
Query: 295 KAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPE-GLTPDLVQEAC 353
+ ++ + S KT+ QD ++ + ++ E PE L D +++
Sbjct: 1615 RPMSISPPDFSPKTAKS-RTPVQDHRSEQ------SSMSIEFGQESPEQSLAMDFSRQSP 1667
Query: 354 ESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAP 413
+ I ++ + MQ+S + P EE T L +++ +
Sbjct: 1668 DHPTVGAGVLHITENGPTEVDYSPSDMQDS--SLSHKIPPMEEPSYTQDNDLSELISVSQ 1725
Query: 414 LNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSL--KKVSGIKEEI 471
+ ++ ++ A +SPL+ +++ + PP + ++ SL +KV ++ E
Sbjct: 1726 VEASPSTSSAHTPSQIASPLQEDTLS--------DVAPPRDMSLYASLTSEKVQSLEGEK 1777
Query: 472 KEPENINAALQETEA-----PYISIACDLIKETKL----SAEPAPDFSD---YSEMAKVE 519
P++ + L E+ P S + +KE S+ P D + Y A V
Sbjct: 1778 LSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVL 1837
Query: 520 QPVPDHS----------ELVEDS--------------------SPDSEPVDLFSDDSIPD 549
H L +DS SPD E D S +
Sbjct: 1838 FDTMQHHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTR 1897
Query: 550 VP-------QKQDETVMLVKES---------LTETSFESMIEYENKEKLSALPPEGGKPY 593
+K + T +S T+T + YE EK + P EGG Y
Sbjct: 1898 TSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSY 1957
Query: 594 LESFKLSLDNTKDTLLPDEVSTLS--KKEKIPLQMEELSTAVYSNDD 638
D ++ T P EVS S K E+ ++++S ++D
Sbjct: 1958 --------DISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSED 1996
Score = 32.3 bits (72), Expect = 2.2
Identities = 113/583 (19%), Positives = 206/583 (35%), Gaps = 83/583 (14%)
Query: 2 DLKEQPGNTISAGQEDFPSV-LLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEG--- 57
D +E + ++ P + L+E L P+ A ++ + P EG
Sbjct: 839 DFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITT 898
Query: 58 TLQENVSEASKEVSEKAKTLLIDRDLTEFSE--LEYSEMGSSFSVSPKAESAVIVANPRE 115
T E E + E E + +D D+ +F + + E + KAE+ E
Sbjct: 899 TEGEGECEQTPEELEPVEKQGVD-DIEKFEDEGAGFEESSETGDYEEKAET--------E 949
Query: 116 EIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMR 175
E +D EE + + H+ PT EDE + +A EKR +V +
Sbjct: 950 EAEEPEEDGEEHVCVSASKHS----PT-------EDEESAKAEADAYIREKRESVASGDD 998
Query: 176 EEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVD-KKCFADSLEQTNHEKDSES 234
D E + S+E++D K E E + + +K A+ +K +E+
Sbjct: 999 RAEEDMDEAIEKGEAEQSEEEAD---EEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEA 1055
Query: 235 SNDDTSF-----PSTPEGIKD--RSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTD 287
+ + P+ G + R A P +ES AT + E T
Sbjct: 1056 GGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTA 1115
Query: 288 EKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTD-----NLTKVTEEVVA---N 339
+ +I +E + S P V + ++ + + N+TK + + +
Sbjct: 1116 TSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYS 1175
Query: 340 MPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSF-EESE 398
P +TP + E + T K Y + M+E + + L ++ E +
Sbjct: 1176 KPADVTP--LNGFSEGSKTDATDGK-DYNASASTISPPSSMEEDKFSRSALRDAYCSEVK 1232
Query: 399 ATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEAS-----SVNYESIKHE------- 446
A+ + + D + PS S+ SPLE + SVN+ +E
Sbjct: 1233 ASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEA 1292
Query: 447 ---PENPPPYEEAMSVSLKKVSGIKEEIKEP-ENINAALQETEAPYISIACDLIKETKLS 502
P +P +E + E+ P +++ + T PY D K + L
Sbjct: 1293 EVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHT--PYYQSPTDE-KSSHLP 1349
Query: 503 AE---------------PAPDFSDYSEMAKVEQPVPDHSELVE 530
E A D ++ + ++ +++PVPD +E
Sbjct: 1350 TEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIE 1392
>gi|62241003 cardiomyopathy associated 5 [Homo sapiens]
Length = 4069
Score = 47.0 bits (110), Expect = 9e-05
Identities = 195/873 (22%), Positives = 328/873 (37%), Gaps = 170/873 (19%)
Query: 4 KEQPGNTISAG-QEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQEN 62
+E G+T + E F S + A + P +SPL S + + P T +
Sbjct: 1043 EEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTS 1102
Query: 63 VSE----ASKEVS----EKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPR 114
VSE A K+ + E LI LT SE+E E +S SV +A+ A P
Sbjct: 1103 VSEYLILAQKQKTQAYLEPESEDLIPSHLT--SEVEKGEREASSSV-----AAIPAALPA 1155
Query: 115 EEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPM 174
+ IVK EE K S + + LP ++ + KE E ++ K + ++++A+
Sbjct: 1156 QSSIVK---EETKPASPHSV-----LPDSVPAIKKEQEPTAALTLKAA--DEQMALSKVR 1205
Query: 175 REEYADFKPFERVWEVKDSKEDSDMLAAGGKIESN----LESKVDKKCFADSLEQTNHEK 230
+EE V DS+E + ++ K+E ES++ D +++
Sbjct: 1206 KEEI-----------VPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPK--- 1251
Query: 231 DSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKK 290
+G+K + +T + ++ N ++ + +T
Sbjct: 1252 ---------------KGVKPKLVLNVT----SELEQRKLSKNEPEVIKPYSPLKETSLSG 1292
Query: 291 IEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQ 350
E A + K+ S T+ P ++ + S E+ V + P L +
Sbjct: 1293 PEALSAVKMEMKHDSKITTTPIVLHSASSG------------VEKQVEHGPPALAFSALS 1340
Query: 351 EACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCP-----SFEESEATPSPVL 405
E + E+ + T A TK+D T V +E ++ + P + + L
Sbjct: 1341 EEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGL 1400
Query: 406 PDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVS 465
P +V A +S + I+ +SP+E SS + + E +E SL VS
Sbjct: 1401 PPLVTSADEHSVLAEEDKVAIK-GASPIETSSKHLAWSEAE-------KEIKFDSLPSVS 1452
Query: 466 GIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVE------ 519
I E ++ L E EA + +IK + + SD SE A+VE
Sbjct: 1453 SIAE--------HSVLSEVEAKEVKAGLPVIKTS------SSQHSDKSEEARVEDKQDLL 1498
Query: 520 -QPVPDHSELV-----------EDSSPDSE-PVDLF-----SDDSIPDVPQKQDETVMLV 561
V D LV E P+ E P+ L+ + +P + ++
Sbjct: 1499 FSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHII 1558
Query: 562 KESLTETSFESMIEYEN-----KEKLSALPPEGGKPYLE---SFKLSLDNTKDTLLPDEV 613
+ E + S E EN L L + KP +E + + + K + E+
Sbjct: 1559 PKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAEL 1618
Query: 614 STLSKKEKIPLQMEELSTA--VYSND-----DLFISKEAQ--IRETE-TFSDSSPIEI-- 661
S +K+ P Q EL A +S+D +K+A+ I ETE + + P E+
Sbjct: 1619 SLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRS 1678
Query: 662 ---IDEFPTLISSKT----DSFSKLAREYTDLE---------VSHKSEIANAPDGAGSLP 705
+E L +S T S L RE + E +S +S+ A G P
Sbjct: 1679 REGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNP 1738
Query: 706 CTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALA-TQAEIESIVKP 764
P SLK + E++S DF K G+ ++ LPP + A +I +
Sbjct: 1739 EEFQPFTFSLKGL----SEEVSHPADFKKGGN--QEIGPLPPTGNLKAQVMGDILDKLSE 1792
Query: 765 KVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKT 797
+ + + L S TE +PS + E KT
Sbjct: 1793 ETGHPNSSQVLQSITEPSKIAPSDLL-VEQKKT 1824
Score = 45.4 bits (106), Expect = 3e-04
Identities = 155/674 (22%), Positives = 244/674 (36%), Gaps = 104/674 (15%)
Query: 193 SKEDSDMLAAGGKIE--SNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKD 250
S ED + A + S LE V + EQ + S+S + P ++
Sbjct: 319 SHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQSVPQQPEDEAKPHEVEP 378
Query: 251 RSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKI---EEKKAQIVTEKNT-ST 306
S T A T+ P G SEN + E KK + + ++ S
Sbjct: 379 PSVTPDTPATMFLRTTKEECELASP--GTAASENDSSVSPSFANEVKKEDVYSAHHSISL 436
Query: 307 KTSNPFLVAA-QDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKI 365
+ ++P L A+ QD +LT + E + LTP E E N + +
Sbjct: 437 EAASPGLAASTQDGLDPDQEQPDLTSI--ERAEPVSAKLTPTHPSVKGEKEENMLEPSIS 494
Query: 366 AYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASV 425
E M E ++ SL P A + P E+S ++ E+PL S P
Sbjct: 495 LSEPLMLEEPEKEEIETSL-PIA-ITPEPEDSNLVEEEIVELDYPESPLVSEKP------ 546
Query: 426 IQPSSSP-------------LEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIK 472
P SP L ASS + ++ E EE SVS S E
Sbjct: 547 FPPHMSPEVEHKEEELILPLLAASSPEHVALSEEER-----EEIASVSTG--SAFVSEYS 599
Query: 473 EPENINAALQETEAPYI--SIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVE 530
P+++N LQE E + S + + LS E +F YS A E
Sbjct: 600 VPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTE 659
Query: 531 DSSPDSEPVD---------LFSDDS------IPDVPQKQDETV--MLVKESLTETS---- 569
+S + P+ L D++ PD + +V + KESL +T
Sbjct: 660 KTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKS 719
Query: 570 -------FESMIEYENKEKLSALPPE---GGKPYLESFKLSLDNTKDTLLPDEVSTLSKK 619
E MI E KE + P +P L + + LP ST + +
Sbjct: 720 PLILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLP---STATSE 776
Query: 620 EKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFS-K 678
+P + E+L + ++ D ISK A +P+ E I ++ F K
Sbjct: 777 HVVPSEGEDLGSERFTPDSKLISKYA-----------APLNATQESQKKIINEASQFKPK 825
Query: 679 LAREYTDLEVSHKSEIA-NAPD----GAGSLP--CTELPHDLSLKNIQPKVEEKISFSDD 731
E+T L V K I ++PD S P TE+ + + E + SD+
Sbjct: 826 GISEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDE 885
Query: 732 FSKN------GSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLP-SDTEKEDR 784
+ S ++ +PP + +A+ E IV + +K A + S+ ++ED
Sbjct: 886 EAVELERYTPSSTSASEFSVPPYAT---PEAQEEEIVHRSLNLKGASSPMNLSEEDQEDI 942
Query: 785 SPSAIFSAELSKTS 798
P + SA +S+ S
Sbjct: 943 GPFSPDSAFVSEFS 956
Score = 31.2 bits (69), Expect = 5.0
Identities = 75/371 (20%), Positives = 146/371 (39%), Gaps = 53/371 (14%)
Query: 427 QPSSSPLEASSVNYESIKHEPENP--PPYEEAMSVSLKKVSGIKEEIKEPENINAALQET 484
QP S+ +S N +PE+ P E S+ +K+E++ P ++ + +ET
Sbjct: 2387 QPKSASSNFASKNITKESEKPESIILPVEESKGSLIDFSEDRLKKEMQNPTSLKISEEET 2446
Query: 485 EAPYISIA---------CDLIKETKLSAEP----AP-DFSDYSEMAKVEQPVPDHSELVE 530
+ +S + E K+ AE AP + D +E+ K + + S ++
Sbjct: 2447 KLRSVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELK 2506
Query: 531 DSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGG 590
+S D+ P + ++ D ++ V KE E + + E K++ +
Sbjct: 2507 ESKADAMPQHFYQNE---DYNERPKIIVGSEKEKGEEKENQVYVLSEGKKQ------QEH 2557
Query: 591 KPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRET 650
+PY + S+ D L + E + + ++ ++ + +IRE
Sbjct: 2558 QPYSVNVAESMSRESDISLGHSLG-----ETQSFSLVKATSVTEKSEAMLAEAHPEIREA 2612
Query: 651 ETF-SDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIAN---APDGAGSLPC 706
+ + P+E E L+ KT +F +A +S + EI N + +G
Sbjct: 2613 KAVGTQPHPLE---ESKVLV-EKTKTFLPVA-------LSCRDEIENHSLSQEG------ 2655
Query: 707 TELPHDLSLKNIQPKVEEKISFSD-DFSKNGSATSKVLLLPPDVSALATQAEIESIVKPK 765
L + S +++ EEK F + + SK GS + A + + + K
Sbjct: 2656 -NLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRPLEESK 2714
Query: 766 VLVKEAEKKLP 776
VLV++ + LP
Sbjct: 2715 VLVEKTKTFLP 2725
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 45.8 bits (107), Expect = 2e-04
Identities = 134/669 (20%), Positives = 241/669 (36%), Gaps = 112/669 (16%)
Query: 59 LQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEII 118
++E ++EA EV+E+ + D E E E +E S +A S + +A+ E+ +
Sbjct: 300 IRELIAEAKAEVTEEVE------DGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKL 353
Query: 119 VKNK------------------------------DEEEKLVSNNILHNQQELPTALTKLV 148
+N DE EK V + H A+T+L
Sbjct: 354 SQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELH 413
Query: 149 KEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVW--EVKDSKEDSDMLAAGGKI 206
V+ K++ EKR P E D + E V V + KE++ M+ I
Sbjct: 414 DRTAVI-----KENEREKR-----PKLENLPDTEDQETVDINSVSEGKENNIMITLETNI 463
Query: 207 ESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAAT 266
E NL+S+ EKD E + E IKD +
Sbjct: 464 EHNLKSE--------------EEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEK 509
Query: 267 ESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTS-----TKTSNPFLVAAQDSET 321
E+ + +G ++ T EK E+ K Q NTS + ++ +DS
Sbjct: 510 EANIQAVDSEVG--LTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAE 567
Query: 322 DYVTTD--NLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEV 379
D + D + +V ++++ G +E E+ E+ + + + + +
Sbjct: 568 DTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENI 627
Query: 380 MQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVN 439
M + P ES +T + +V + + S +AS V
Sbjct: 628 MDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKAL-----------GSEVQDASKVT 676
Query: 440 YESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKET 499
+ K + E P VS+K KEPE + Q TE + LI
Sbjct: 677 TQIDKEKKEIP--------VSIK---------KEPE-VTVVSQPTEPQPV-----LIPSI 713
Query: 500 KLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVM 559
++++ + + ++K E +P SE +++ DS +D S D+ +
Sbjct: 714 NINSDSGENKEEIGSLSKTETILPPESENPKENDNDS-GTGSTADTSSIDLNLSISSFLS 772
Query: 560 LVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKK 619
K+S + + E+ + + +K +G + + + K+ D+ T +E+ L ++
Sbjct: 773 KTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKT---EELRFLRRQ 829
Query: 620 EKIP---LQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSF 676
E LQ EE N L +E R E S + E L + +
Sbjct: 830 ELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTI 889
Query: 677 SKLAREYTD 685
+L +E+T+
Sbjct: 890 ERLEQEHTN 898
Score = 32.7 bits (73), Expect = 1.7
Identities = 134/679 (19%), Positives = 256/679 (37%), Gaps = 95/679 (13%)
Query: 10 TISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKE 69
+I++ +ED L + A L S+S + S E + + PT ++ V + ++
Sbjct: 344 SIASSEED---KLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEH 400
Query: 70 VSE---KAKTLLIDRD-------------LTEFSELEYSEMGSSFSVSPKAESAVIVA-- 111
+++ +A T L DR L + E E SVS E+ +++
Sbjct: 401 ITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLE 460
Query: 112 -----NPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEK 166
N + E + KD+E++ + N L +E+ + + V ++VS E + N +
Sbjct: 461 TNIEHNLKSE---EEKDQEKQQMFENKLIKSEEIKDTILQTV---DLVSQETGEKEANIQ 514
Query: 167 RVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESK-VDKKCFADSLEQ 225
V E + +E K E D K D+++ + E+ V +K DS E
Sbjct: 515 AVDSEVGLTKEDTQEKLGE------DDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAED 568
Query: 226 TNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENK 285
T SND + + ++ E+ T P+ + N+
Sbjct: 569 TQ-------SNDGKEVVEVGQKLINKP----------MVGPEAGGTKEVPIK-EIVEMNE 610
Query: 286 TDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTE--EVVANMPEG 343
+E K K+ I + +N P +E + +T + T+ E VVA+ +
Sbjct: 611 IEEGK--NKEQAINSSENIMDINEEP-----GTTEGEEITESSSTEEMEVRSVVADTDQK 663
Query: 344 LTPDLVQEAC------ESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQL-CPSFEE 396
VQ+A + E E+ I E ++ +V Q L P+ + S E
Sbjct: 664 ALGSEVQDASKVTTQIDKEKKEIP-VSIKKEPEVTVVSQPTEPQPVLIPSININSDSGEN 722
Query: 397 SEATPSPVLPDIVM----EAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPP 452
E S + ++ E P + S S SS L S ++ S
Sbjct: 723 KEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLS---------K 773
Query: 453 YEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETK-LSAEPAPDFSD 511
+++ S+SL++ K+ +K+ E I D +T+ L + +
Sbjct: 774 TKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRE 833
Query: 512 YSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFE 571
+ K EQ +L E + + + ++ D+ + +++ +T
Sbjct: 834 LRFLQKEEQRA--QQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIER 891
Query: 572 SMIEYENKEKLSALPPEGGKPY-LESFKLSLDNTKDTLLPDEVSTLSK---KEKIPLQME 627
E+ N+ + A +G + L F+ L N K ++ +EV K KE + + E
Sbjct: 892 LEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVI-NEVEKAPKELRKELMKRRKE 950
Query: 628 ELSTAVYSNDDLFISKEAQ 646
EL+ + ++ + F+ K+ Q
Sbjct: 951 ELAQSQHAQEQEFVQKQQQ 969
>gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens]
Length = 1844
Score = 43.9 bits (102), Expect = 7e-04
Identities = 141/734 (19%), Positives = 274/734 (37%), Gaps = 100/734 (13%)
Query: 59 LQENVSEASKEVS-EKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEI 117
++ ++S+ E + +K K+ ++ ++ E EL E GSS +V PK R++
Sbjct: 351 MENSLSDPENEQTVQKRKSNVVIQE--EELELAVLEAGSSEAVKPKC-----TLEERQQF 403
Query: 118 IVKNKDEEEKLVSNNILHN---QQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPM 174
+ + + N + + Q++L V D+ +S+K ++ + V+ +
Sbjct: 404 MKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDD--NSKKIMENSGIQMVSKNGNL 461
Query: 175 REEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSES 234
+ + D F + K K++ L G N E KK L++ ++
Sbjct: 462 -QLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSL 520
Query: 235 SNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATN--IFPLLGDPTSENKTDEKKIE 292
T F + + S Y A + S+ N + P + K + K E
Sbjct: 521 RQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAE 580
Query: 293 EKKAQIVTEKNTSTK-----TSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEG---L 344
+ + + ST+ +S P + ++D V ++ K + + AN+ E
Sbjct: 581 SEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLY 640
Query: 345 TPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPV 404
T +L+ +SE K + T + ++ + E+SEAT
Sbjct: 641 TAELITVPFDSES--------PIRMKFTRISTPKKSKKKSNKRS------EKSEATDGGF 686
Query: 405 LPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYE-------SIKHE--PENPPPYEE 455
I + + + A + + + + S V E S +H+ PE E
Sbjct: 687 TSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSET 746
Query: 456 AMSVSLKKVSGIKEEIKEPEN---------------INAALQETEAPYISIACDLIKETK 500
SV + + +K PE +N + + L+++ +
Sbjct: 747 EDSVII--IDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQ 804
Query: 501 LSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQ--DETV 558
+A+P P F + S+ D SE +D + F +PD+ ++Q +
Sbjct: 805 KAADPVPSFDESSQ---------DTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAA 855
Query: 559 MLVKESLTETSFESMIEYENKEKLSAL----PPEGGKPYLESFK----LSLDNTKDTLLP 610
L + TSF+ ++ + K+ L PP P L FK +D +K +
Sbjct: 856 ALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPP--SCPLLTKFKELNTKVIDLSKCGIAL 913
Query: 611 DEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSP-IEIIDEFPTLI 669
E STL+ K K S AV+ ++E + E S+P + FP L+
Sbjct: 914 GEFSTLNSKLK-----SGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLL 968
Query: 670 SSKTD----SFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEK 725
+ + S +++ + +VSHK + S + P++ S KN++ K K
Sbjct: 969 KKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYS-KNLE-KTNRK 1026
Query: 726 ISFSDDFSKNGSAT 739
S++ SK +++
Sbjct: 1027 ---SEELSKRNNSS 1037
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 43.1 bits (100), Expect = 0.001
Identities = 69/325 (21%), Positives = 130/325 (40%), Gaps = 41/325 (12%)
Query: 224 EQTNHEKDSESSNDDTSFPST---PEGIKDRSGAYI---------TCAPFNPAATESIAT 271
EQ E+ E+S TS PS E +K+ A + TCAP +P +
Sbjct: 1285 EQVTVEEQKETSEGKTS-PSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKP 1343
Query: 272 NIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTK 331
L+ E + +E++ EE++ + E+ +P +Q+ E ++T+
Sbjct: 1344 ED-DLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTE---- 1398
Query: 332 VTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDL--VQTSEVMQESLYPAAQ 389
+E A + + + +E E NE ++ M+ V+ E+ +ES +
Sbjct: 1399 --KEDSARLDDHEEEE--EEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLE 1454
Query: 390 LCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPEN 449
+F + P P+++M+ ++ +S P E + + E++ E
Sbjct: 1455 NQETFLDLNVQPGHSNPEVLMDCGVDLTASC--------NSEPKELAG-DPEAVPESDEE 1505
Query: 450 PPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDF 509
PPP E+A K + E KE N A E ++ + L +E S+E F
Sbjct: 1506 PPPGEQAQKQDQKNSKEVDTEFKEG---NPATMEIDSETVQAVQSLTQE---SSEQDDTF 1559
Query: 510 SDYSEMAKVEQPVPDHSELVEDSSP 534
D +E + + + +++ D SP
Sbjct: 1560 QDCAETQEACRSLQNYTR--ADQSP 1582
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 42.4 bits (98), Expect = 0.002
Identities = 112/554 (20%), Positives = 209/554 (37%), Gaps = 62/554 (11%)
Query: 52 VLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAE--SAVI 109
V PTE +E S+ K+ +K K D + +E ELE + S + PK E S
Sbjct: 81 VKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSE--ELEDKDSKSKKTAKPKVEMYSGSD 138
Query: 110 VANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVA 169
+ ++ K K + +K SN +E K+ + + SS ++ D +E +
Sbjct: 139 DDDDFNKLPKKAKGKAQK--SNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQS 196
Query: 170 VEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHE 229
+ + + P ++ ED D A KI++ + K +KK E+ +
Sbjct: 197 RKGQKKNQKNKPGP-----NIESGNEDDD---ASFKIKTVAQKKAEKK----ERERKKRD 244
Query: 230 KDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATES---IATNIFPLLGD----PTS 282
++ G KD+S + F +S + T + P + PT+
Sbjct: 245 EEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTA 304
Query: 283 ---ENKTDEKKIEEKKAQIVTEKNTSTKTSNP---FLVAAQDSETDYVTTDNLTK-VTEE 335
+N+ D+KK ++KK + E+ K P + A Q++ + K EE
Sbjct: 305 AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364
Query: 336 VVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPA---AQLCP 392
+ + E +E E E E K E K L + +++ +S A A+
Sbjct: 365 RIKRLEELEAKRKEEERLEQEKRERKKQK-EKERKERLKKEGKLLTKSQREARARAEATL 423
Query: 393 SFEESEATPSPVLPDIVMEAPL-----NSAVP-SAGASVIQPSSSPLEASSVNYESIKHE 446
+++ P + + P+ +P + + S A V + + +
Sbjct: 424 KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEK 483
Query: 447 PENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPA 506
E PPP E +E + +A L + EA + ++ K+ E
Sbjct: 484 EETPPPVEPE---------------EEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE-V 527
Query: 507 PDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLT 566
+ + E + E+ + SE E+ +SE + D+ V ++D L K+
Sbjct: 528 KENPEEEEEEEEEEEEDEESEEEEEEEGESEGSE--GDEEDEKVSDEKDSGKTLDKKPSK 585
Query: 567 ETSFESMIEYENKE 580
E S +S EY++ +
Sbjct: 586 EMSSDS--EYDSDD 597
>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
Length = 2803
Score = 42.0 bits (97), Expect = 0.003
Identities = 88/437 (20%), Positives = 160/437 (36%), Gaps = 45/437 (10%)
Query: 375 QTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLE 434
Q EV++ YP L P ES + S PD + P + + P E
Sbjct: 1133 QKDEVLR---YPDRSLSPEDAESLSVLSVPSPDTANQEPTPKSPCGLTEQYLHKDRWP-E 1188
Query: 435 ASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACD 494
S + +S+ E+P E ++ VS K++S E + + L + E ++ A D
Sbjct: 1189 VSPEDTQSLSLSEESPSK-ETSLDVSSKQLS--PESLGTLQFGELNLGKEEMGHLMQAED 1245
Query: 495 LIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDS-------I 547
T + P P + S +++ +DS P FS + +
Sbjct: 1246 TSHHTAPMSVPEPHAATASPPTDGTTRYSAQTDITDDSLDRKSPASSFSHSTPSGNGKYL 1305
Query: 548 PDVPQKQDETVMLVKESLTETSFESM-------IEYENKEKLSALPPEGGKPYLESFKLS 600
P DE ++ S +++ ES+ I + ++K+ L + E
Sbjct: 1306 PGAITSPDEHILTPDSSFSKSP-ESLPGPALEDIAIKWEDKVPGLKDRTSEQKKEP---- 1360
Query: 601 LDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIE 660
KD +L + TL KE + E TA+Y D+ K +++ + + +
Sbjct: 1361 --EPKDEVLQQKDKTLEHKEVV----EPKDTAIYQKDEALHVKNEAVKQQDKALEQKGRD 1414
Query: 661 IIDEFPTLISSKTDSFSKLAR--EYTDLEVSHKSEIANAPDGAGSLPCTELPH------- 711
+ ++ T + K + + E D + K +I D A T L
Sbjct: 1415 L-EQKDTALEQKDKALEPKDKDLEEKDKALEQKDKIPEEKDKALEQKDTALEQKDKALEP 1473
Query: 712 ---DLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLV 768
DL K+ + +EKI D + + S P D A ++E K
Sbjct: 1474 KDKDLEQKDRVLEQKEKIPEEKDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKAPEQK 1533
Query: 769 KEAEKKLPSDTEKEDRS 785
+A+++ +EK+D++
Sbjct: 1534 HQAQEQKDKVSEKKDQA 1550
Score = 30.4 bits (67), Expect = 8.5
Identities = 76/376 (20%), Positives = 139/376 (36%), Gaps = 54/376 (14%)
Query: 454 EEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYS 513
+E++ + K + + + K E + +E + K+ K S+E P+
Sbjct: 320 KESLKATTK--TAVSKLAKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKP 377
Query: 514 EMAKVEQPVPDHSE---LVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSF 570
E K E +E L++D + I + +K+D+ +K+ E
Sbjct: 378 ERVKTESSEALKAEKRKLIKDKVGKKH-----LKEKISKLEEKKDKEKKEIKKERKELKK 432
Query: 571 ESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQME-EL 629
+ + E K+ + KP L+ K+S + K EV K K+P +++ +
Sbjct: 433 DEGRKEEKKDAKKEEKRKDTKPELK--KISKPDLKP--FTPEVRKTLYKAKVPGRVKIDR 488
Query: 630 STAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSK----TDSFSKLAREYTD 685
S A+ +L S E Q + + P+ I L+ S T F ++ RE
Sbjct: 489 SRAIRGEKEL--SSEPQTPPAQ--KGTVPLPTISGHRELVLSSPEDLTQDFEEMKREERA 544
Query: 686 LEVSHKSE--------IANAPDGAGSLPCTELP----------HDLSLKNIQPKVEEKIS 727
L + + A +G S P H + K + P+V E+
Sbjct: 545 LLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGLGQEEHVMKEKELVPEVPEEQG 604
Query: 728 FSDDFSKNGSATSK------------VLLLPPDVSALA-TQAEIESIVKPKVLVKEAEKK 774
D +G+ T + LP A ++ E++ V K ++E E+
Sbjct: 605 SKDRGLDSGAETEEEKDTWEEKKQREAERLPDRTEAREESEPEVKEDVIEKAELEEMEEV 664
Query: 775 LPSDTEKEDRSPSAIF 790
PSD E+ED + + F
Sbjct: 665 HPSDEEEEDATKAEGF 680
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 42.0 bits (97), Expect = 0.003
Identities = 96/414 (23%), Positives = 148/414 (35%), Gaps = 83/414 (20%)
Query: 96 SSFSVSPKAESAVIVANPR--EEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEV 153
SS PK E+ + + EEII + K E+EK E+ ALT + +E V
Sbjct: 433 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEK----------SEMEEALTAITEELAV 482
Query: 154 VSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVW-EVKDSKEDSDMLAAGGKIESNLES 212
E+ K++ EK EA E A P + EVK+ E+ + G+ E E
Sbjct: 483 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE--EEGEKEEEEGQEE---EE 537
Query: 213 KVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATN 272
+ D+ +D E+ EK+ S + EG ++ TE+ A
Sbjct: 538 EEDEGAKSDQAEEGGSEKEGSSEKE--------EGEQEE------------GETEAEA-- 575
Query: 273 IFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKV 332
+ +EKK+EEK ++ T++ LVA E + K
Sbjct: 576 ------EGEEAEAKEEKKVEEKSEEVATKEE---------LVADAKVEKPEKAKSPVPKS 620
Query: 333 TEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCP 392
E P +P V+E +S V S V ++ P P
Sbjct: 621 PVEEKGKSPVPKSP--VEEKGKSP-----------------VPKSPVEEKGKSPV----P 657
Query: 393 SFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPP 452
E SPV V E S VP S ++ + S E + + + P
Sbjct: 658 KSPVEEKGKSPVSKSPV-EEKAKSPVPK---SPVEEAKSKAEVGKGEQKEEEEKEVKEAP 713
Query: 453 YEEAMSVSLKKVSGIKEEIKEPENI-NAALQETEAPYISIACDLIKETKLSAEP 505
EE + +K + E+ K + A+ E S+ L KETK +P
Sbjct: 714 KEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 767
Score = 40.8 bits (94), Expect = 0.006
Identities = 69/317 (21%), Positives = 129/317 (40%), Gaps = 41/317 (12%)
Query: 282 SENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMP 341
+E K +E + EE++ V K + K + P ++ E + + + EE
Sbjct: 492 AEEKEEEPEAEEEE---VAAKKSPVKATAP---EVKEEEGEKEEEEGQEEEEEE-----D 540
Query: 342 EGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESE--A 399
EG D +E +E G+ E + + +T + A + E+SE A
Sbjct: 541 EGAKSDQAEEGG----SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 596
Query: 400 TPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSV 459
T ++ D +E P + P + V + SP+ S V + P++ P EE
Sbjct: 597 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS--PVEEKGKS 654
Query: 460 SLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVE 519
+ K S ++E+ K P + + ++ ++P + P + +E+ K E
Sbjct: 655 PVPK-SPVEEKGKSPVSKSPVEEKAKSP-------------VPKSPVEEAKSKAEVGKGE 700
Query: 520 QPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTET-----SFESMI 574
Q + E+ E +P E V+ ++ DVP+K+ + +E++ E S + +
Sbjct: 701 QKEEEEKEVKE--APKEEKVEK-KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHL 757
Query: 575 EYENKEKLSALPPEGGK 591
E E KE+ L E K
Sbjct: 758 EKETKEEGKPLQQEKEK 774
Score = 36.6 bits (83), Expect = 0.12
Identities = 60/337 (17%), Positives = 119/337 (35%), Gaps = 23/337 (6%)
Query: 56 EGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVA--NP 113
E ++E E K E+A T + + E E E P+AE + A +P
Sbjct: 454 EEIIEETKVEDEKSEMEEALTAITEELAVSMKE-EKKEAAEEKEEEPEAEEEEVAAKKSP 512
Query: 114 REEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAP 173
+ + K+EE + ++E EDE S++A++ +EK + E
Sbjct: 513 VKATAPEVKEEEGEKEEEEGQEEEEE----------EDEGAKSDQAEEGGSEKEGSSEKE 562
Query: 174 MREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSE 233
E+ E E ++KE+ + ++ + E D K ++ K
Sbjct: 563 EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPV 622
Query: 234 SSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLG-DPTSENKTDEKKIE 292
+ P +P ++++ + + +P + + G P S++ +EK
Sbjct: 623 EEKGKSPVPKSP--VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 680
Query: 293 EKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEA 352
V E + + ++ E + + EE ++PE ++
Sbjct: 681 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPE-------KKK 733
Query: 353 CESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQ 389
ES + E ++ TK V + +E P Q
Sbjct: 734 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ 770
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 42.0 bits (97), Expect = 0.003
Identities = 96/414 (23%), Positives = 148/414 (35%), Gaps = 83/414 (20%)
Query: 96 SSFSVSPKAESAVIVANPR--EEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEV 153
SS PK E+ + + EEII + K E+EK E+ ALT + +E V
Sbjct: 57 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEK----------SEMEEALTAITEELAV 106
Query: 154 VSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVW-EVKDSKEDSDMLAAGGKIESNLES 212
E+ K++ EK EA E A P + EVK+ E+ + G+ E E
Sbjct: 107 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE--EEGEKEEEEGQEE---EE 161
Query: 213 KVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATN 272
+ D+ +D E+ EK+ S + EG ++ TE+ A
Sbjct: 162 EEDEGAKSDQAEEGGSEKEGSSEKE--------EGEQEE------------GETEAEA-- 199
Query: 273 IFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKV 332
+ +EKK+EEK ++ T++ LVA E + K
Sbjct: 200 ------EGEEAEAKEEKKVEEKSEEVATKEE---------LVADAKVEKPEKAKSPVPKS 244
Query: 333 TEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCP 392
E P +P V+E +S V S V ++ P P
Sbjct: 245 PVEEKGKSPVPKSP--VEEKGKSP-----------------VPKSPVEEKGKSPV----P 281
Query: 393 SFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPP 452
E SPV V E S VP S ++ + S E + + + P
Sbjct: 282 KSPVEEKGKSPVSKSPV-EEKAKSPVPK---SPVEEAKSKAEVGKGEQKEEEEKEVKEAP 337
Query: 453 YEEAMSVSLKKVSGIKEEIKEPENI-NAALQETEAPYISIACDLIKETKLSAEP 505
EE + +K + E+ K + A+ E S+ L KETK +P
Sbjct: 338 KEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 391
Score = 40.8 bits (94), Expect = 0.006
Identities = 69/317 (21%), Positives = 129/317 (40%), Gaps = 41/317 (12%)
Query: 282 SENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMP 341
+E K +E + EE++ V K + K + P ++ E + + + EE
Sbjct: 116 AEEKEEEPEAEEEE---VAAKKSPVKATAP---EVKEEEGEKEEEEGQEEEEEE-----D 164
Query: 342 EGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESE--A 399
EG D +E +E G+ E + + +T + A + E+SE A
Sbjct: 165 EGAKSDQAEEGG----SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVA 220
Query: 400 TPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSV 459
T ++ D +E P + P + V + SP+ S V + P++ P EE
Sbjct: 221 TKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS--PVEEKGKS 278
Query: 460 SLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVE 519
+ K S ++E+ K P + + ++ ++P + P + +E+ K E
Sbjct: 279 PVPK-SPVEEKGKSPVSKSPVEEKAKSP-------------VPKSPVEEAKSKAEVGKGE 324
Query: 520 QPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTET-----SFESMI 574
Q + E+ E +P E V+ ++ DVP+K+ + +E++ E S + +
Sbjct: 325 QKEEEEKEVKE--APKEEKVEK-KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHL 381
Query: 575 EYENKEKLSALPPEGGK 591
E E KE+ L E K
Sbjct: 382 EKETKEEGKPLQQEKEK 398
Score = 36.6 bits (83), Expect = 0.12
Identities = 60/337 (17%), Positives = 119/337 (35%), Gaps = 23/337 (6%)
Query: 56 EGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVA--NP 113
E ++E E K E+A T + + E E E P+AE + A +P
Sbjct: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKE-EKKEAAEEKEEEPEAEEEEVAAKKSP 136
Query: 114 REEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAP 173
+ + K+EE + ++E EDE S++A++ +EK + E
Sbjct: 137 VKATAPEVKEEEGEKEEEEGQEEEEE----------EDEGAKSDQAEEGGSEKEGSSEKE 186
Query: 174 MREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSE 233
E+ E E ++KE+ + ++ + E D K ++ K
Sbjct: 187 EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPV 246
Query: 234 SSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLG-DPTSENKTDEKKIE 292
+ P +P ++++ + + +P + + G P S++ +EK
Sbjct: 247 EEKGKSPVPKSP--VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKS 304
Query: 293 EKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEA 352
V E + + ++ E + + EE ++PE ++
Sbjct: 305 PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPE-------KKK 357
Query: 353 CESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQ 389
ES + E ++ TK V + +E P Q
Sbjct: 358 AESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ 394
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 41.2 bits (95), Expect = 0.005
Identities = 105/526 (19%), Positives = 203/526 (38%), Gaps = 45/526 (8%)
Query: 278 GDPTSENKTDEKKIEEKKAQIVTEKNTST----KTSNPFLVAAQDSETDYVTTDNLTKVT 333
G ++ K K+IE +K ++ + +++T K S + + ++L V+
Sbjct: 1301 GTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVS 1360
Query: 334 EEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPS 393
E + + +Q+ ES ++ G + E + L + +++ + + L
Sbjct: 1361 HEAEVHA------ESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414
Query: 394 FEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPY 453
E EA + + +I+ + L A+ + + ++ V +K +PE
Sbjct: 1415 LSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE 1474
Query: 454 EEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYS 513
A +K+ KE N +LQE +S+A I+ +L+ A S S
Sbjct: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEE----LSLARGTIE--RLTKSLADVESQVS 1528
Query: 514 EMAKVEQPVPDHSELVE---DSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSF 570
K + V L++ D L + S+ E++ L E LTE
Sbjct: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL----SSSCESLKLALEGLTEDKE 1584
Query: 571 ESMIEYEN-KEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEEL 629
+ + E E+ K A E + + E L + LL + ++ E+I +E +
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKE-----LQKEYEILLQSYENVSNEAERIQHVVEAV 1639
Query: 630 STAVYSNDDLFISKEAQIRETE---TFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDL 686
S EA +ETE ++ E+ ++ SK +L E L
Sbjct: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRL 1699
Query: 687 EVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVE---EKIS--FSDDFSKNGSATSK 741
++E+ A D A T L + S+K +V+ E +S F S+ S + +
Sbjct: 1700 ----RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEE 1755
Query: 742 VLLLPPDVSA-LATQAEIESIVK---PKVLVKEAEKKLPSDTEKED 783
V L + ++ QA +E+ K + +E + +P +TE++D
Sbjct: 1756 VQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQD 1801
>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
Length = 674
Score = 41.2 bits (95), Expect = 0.005
Identities = 102/547 (18%), Positives = 207/547 (37%), Gaps = 79/547 (14%)
Query: 205 KIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFP--STPEGIKDRSGAYITCAPFN 262
K +S L +++ ++ ++ E+ E + +S+ + P ++ EGI S + +
Sbjct: 42 KADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVP-SETE 100
Query: 263 PAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETD 322
P + + + +G+ + + + ++ E+ T + FL +A +++ D
Sbjct: 101 PGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD 160
Query: 323 YVT-TDNLTKVTEEVVAN-----MPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQT 376
V T+ +++V+ V + E P + +E+ + +E TG + +TK D
Sbjct: 161 PVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQ-HEETGLEPPEQTKQD---- 215
Query: 377 SEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEAS 436
+P+ +L S EE++ P + E P + S +P
Sbjct: 216 --------FPSEKLGESLEETDLQPPKMTKP---ETPEETQRESTEKKRTEPPEQ----- 259
Query: 437 SVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLI 496
E ++ EP EEA L+ + E+ E E A +E
Sbjct: 260 -ARLEFLEKEPRKSS--EEA---GLEPPEETQPEVPE-EMQRKATEE------------- 299
Query: 497 KETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDE 556
K T+L PDF D+ ++ VP+ E ++ P+ E +K +E
Sbjct: 300 KGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEE-------------SRKTNE 346
Query: 557 TVMLVKESLTETSFESMIEYENKEKLSALPPEGG-------KPYLESFKLSLDNTKDTLL 609
+L + + + I N++K P E G P +E + K L
Sbjct: 347 ETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILEL 406
Query: 610 PDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLI 669
PDE T ++ + E+ + S + + E + RE + S + E+ L
Sbjct: 407 PDE--TKPRETHVEFSKEDRPEPIKSKYSVG-NDELEHREPKRGKLSLSDKFRKEYYAL- 462
Query: 670 SSKTDSFSKLAREYTDLEVSHK-----SEIANAPDGAGSLPCTELPHDLSLKNIQPKVEE 724
S +S + Y L+ K E + + +E H+ + ++ +++E
Sbjct: 463 GSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKE 522
Query: 725 KISFSDD 731
++S D+
Sbjct: 523 RVSEDDE 529
Score = 32.7 bits (73), Expect = 1.7
Identities = 38/186 (20%), Positives = 74/186 (39%), Gaps = 14/186 (7%)
Query: 54 PTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANP 113
P E T E E ++ +E+ T L +R +F + + P+ + V P
Sbjct: 280 PPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHK-----------PRKSTDENVPEP 328
Query: 114 REEIIVKNKDEEEKLVSNNILHNQQEL--PTALTKLVKEDEVVSSEKAKDSFNEKRVAVE 171
EEI ++ +EE + + + Q E+ P + ++ K +E + + +++ +
Sbjct: 329 LEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEIN 388
Query: 172 APMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKD 231
P EE KP E++ E+ D + + K + K D LE ++
Sbjct: 389 -PQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRG 447
Query: 232 SESSND 237
S +D
Sbjct: 448 KLSLSD 453
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 40.4 bits (93), Expect = 0.008
Identities = 72/303 (23%), Positives = 119/303 (39%), Gaps = 25/303 (8%)
Query: 280 PTSENK-TDEKKIEEKKAQIVTEKN-TSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVV 337
PT E T E K + I+ E+ T K S P V + + E+ + + KV +
Sbjct: 414 PTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVE-ESPALEAPPMDKVPNPKM 472
Query: 338 ANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEES 397
A P G +++ EL+E + + + E +Q+ Y A+ PS +E
Sbjct: 473 A--PLGDEAPTLEKVLTPELSEEE-VSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEE 529
Query: 398 EATPSPVLPDIVMEAPLNS--AVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEE 455
TP P P +S + ++++ SSP +A + + + E P P+EE
Sbjct: 530 AHTPEAPPPQ-----PPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEE 584
Query: 456 AMSVSLKKVSGIKE--EIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYS 513
A ++ + S + E + P N L+E P +A +E L E P
Sbjct: 585 ATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASK--EEVTLKEELPPK----E 638
Query: 514 EMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPD-VPQKQDETVMLVKESLTETSFES 572
E+A E+ P + + P P D ++P VPQ E E + TS
Sbjct: 639 EVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQNYTEN---KNEGVDVTSLRG 695
Query: 573 MIE 575
+E
Sbjct: 696 EVE 698
Score = 31.2 bits (69), Expect = 5.0
Identities = 57/219 (26%), Positives = 79/219 (36%), Gaps = 52/219 (23%)
Query: 430 SSPLEASSVNYESIKHE---PENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEA 486
SSP++A SV + + PE PP E A S KK+ +++ PE +
Sbjct: 342 SSPVKAPSVKRTPMPDKTATPERPPAPENAPSS--KKIPA-PDKVPSPEKTLTLGDKASI 398
Query: 487 PYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDS 546
P S + + PAPD + P P+ ED + S
Sbjct: 399 PGNSTSGKI---------PAPD----------KVPTPEKMVTPEDKA------------S 427
Query: 547 IPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKD 606
IP+ +ET+ + K S E F E L A P + + N K
Sbjct: 428 IPENSIIPEETLTVDKPSTPERVFS----VEESPALEAPPMD-----------KVPNPKM 472
Query: 607 TLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEA 645
L DE TL K L EE+ST F S+EA
Sbjct: 473 APLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEA 511
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.126 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,600,308
Number of Sequences: 37866
Number of extensions: 1628421
Number of successful extensions: 6388
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 255
Number of HSP's that attempted gapping in prelim test: 5979
Number of HSP's gapped (non-prelim): 696
length of query: 986
length of database: 18,247,518
effective HSP length: 112
effective length of query: 874
effective length of database: 14,006,526
effective search space: 12241703724
effective search space used: 12241703724
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.