Search of human proteins with 46877068

Search of human proteins with 46877068

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46877068 AMP-activated protein kinase alpha 2 catalytic
subunit [Homo sapiens]
         (552 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...  1118   0.0  
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   850   0.0  
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   840   0.0  
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         290   2e-78
gi|116256471 SNF1-like kinase [Homo sapiens]                          280   2e-75
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               275   1e-73
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              273   4e-73
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        271   1e-72
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   269   4e-72
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   269   4e-72
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   269   4e-72
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   267   2e-71
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   266   4e-71
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   266   4e-71
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   266   4e-71
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   266   4e-71
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   266   4e-71
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   266   5e-71
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   259   6e-69
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    249   5e-66
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               241   1e-63
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]           236   3e-62
gi|156105707 SNF related kinase [Homo sapiens]                        221   2e-57
gi|156105705 SNF related kinase [Homo sapiens]                        221   2e-57
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]       213   4e-55
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   203   3e-52
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   178   1e-44
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   178   1e-44
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   177   3e-44
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...   173   4e-43

>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score = 1118 bits (2893), Expect = 0.0
 Identities = 552/552 (100%), Positives = 552/552 (100%)

Query: 1   MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60
           MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
Sbjct: 1   MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60

Query: 61  IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120
           IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF
Sbjct: 61  IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120

Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180
           QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
Sbjct: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180

Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240
           APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
Sbjct: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240

Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300
           VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
Sbjct: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300

Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 360
           ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP
Sbjct: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 360

Query: 361 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 420
           PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
Sbjct: 361 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 420

Query: 421 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 480
           RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
Sbjct: 421 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 480

Query: 481 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 540
           SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
Sbjct: 481 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 540

Query: 541 EMCASLITTLAR 552
           EMCASLITTLAR
Sbjct: 541 EMCASLITTLAR 552


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  850 bits (2195), Expect = 0.0
 Identities = 421/553 (76%), Positives = 476/553 (86%), Gaps = 8/553 (1%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           AEKQKHDGRVKIGHY+LGDTLGVGTFGKVK+G+H+LTGHKVAVKILNRQKIRSLDVVGKI
Sbjct: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
           +REIQNLKLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR++E E+RRLFQ
Sbjct: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 132

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QILS VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA
Sbjct: 133 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 192

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PEVISGRLYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI  G+FY P+YLN SV
Sbjct: 193 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 252

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 301
            +LL HMLQVDP+KRATIKDIREHEWFKQDLP YLFPEDPSY + +IDDEA+KEVCEKFE
Sbjct: 253 ISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFE 312

Query: 302 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPP 361
           C+E EV++ LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SPP  SF+DD  +    
Sbjct: 313 CSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDHHL---- 367

Query: 362 GLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYR 421
             +PHPER+P L+A++P+AR  LD LN  K K   V+KAKWHLGIRSQS+P DIMAEV R
Sbjct: 368 -TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCR 426

Query: 422 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS 481
           A+KQLD+EWKVVN Y+LRVRRKNPVT  Y KMSLQLY VD+R+YLLDF+SIDDE+ E +S
Sbjct: 427 AIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKS 486

Query: 482 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSV--SPRLGSHTMDF 539
           G++TPQRS S +     + S     A+  S   SLT S+T    S V  +PR GSHT++F
Sbjct: 487 GTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEF 546

Query: 540 FEMCASLITTLAR 552
           FEMCA+LI  LA+
Sbjct: 547 FEMCANLIKILAQ 559


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  840 bits (2169), Expect = 0.0
 Identities = 421/568 (74%), Positives = 476/568 (83%), Gaps = 23/568 (4%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           AEKQKHDGRVKIGHY+LGDTLGVGTFGKVK+G+H+LTGHKVAVKILNRQKIRSLDVVGKI
Sbjct: 13  AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI 72

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----------- 110
           +REIQNLKLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR           
Sbjct: 73  RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 132

Query: 111 ----VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 166
               ++E E+RRLFQQILS VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD
Sbjct: 133 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 192

Query: 167 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI 226
           GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI
Sbjct: 193 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 252

Query: 227 RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 286
             G+FY P+YLN SV +LL HMLQVDP+KRATIKDIREHEWFKQDLP YLFPEDPSY + 
Sbjct: 253 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSST 312

Query: 287 VIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSP 346
           +IDDEA+KEVCEKFEC+E EV++ LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SP
Sbjct: 313 MIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSP 372

Query: 347 PSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGI 406
           P  SF+DD  +      +PHPER+P L+A++P+AR  LD LN  K K   V+KAKWHLGI
Sbjct: 373 PD-SFLDDHHL-----TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGI 426

Query: 407 RSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYL 466
           RSQS+P DIMAEV RA+KQLD+EWKVVN Y+LRVRRKNPVT  Y KMSLQLY VD+R+YL
Sbjct: 427 RSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYL 486

Query: 467 LDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLS 526
           LDF+SIDDE+ E +SG++TPQRS S +     + S     A+  S   SLT S+T    S
Sbjct: 487 LDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSS 546

Query: 527 SV--SPRLGSHTMDFFEMCASLITTLAR 552
            V  +PR GSHT++FFEMCA+LI  LA+
Sbjct: 547 PVDLTPRPGSHTIEFFEMCANLIKILAQ 574


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  290 bits (742), Expect = 2e-78
 Identities = 150/346 (43%), Positives = 218/346 (63%), Gaps = 10/346 (2%)

Query: 1   MAEKQKH--DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV 58
           MA+  +H   G V++G Y +  TLG G F  VK+G H++T  +VA+KI+++ ++ ++++ 
Sbjct: 3   MADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLE 62

Query: 59  GKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR 118
            KI RE+Q +K+  HPHIIKLYQV+ T +  ++V EY   GE+FDY+  HGR+ E EARR
Sbjct: 63  -KIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARR 121

Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 178
            F QILSAVDYCH   +VHRDLK EN+LLD +MN KIADFG  N    GE L T CGSP 
Sbjct: 122 KFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPP 181

Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238
           YAAPEV  G+ Y GP++DIWS GV+LY L+CG LPFD   +P L +++  G F IP +++
Sbjct: 182 YAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMS 241

Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP---SYLFPEDPSYDANVID-DEAVK 294
                L+  ML +DP KR TI  I+EH+W   ++P     L+P++   + ++ + +E V 
Sbjct: 242 EDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVL 301

Query: 295 EVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEF 340
            +       + + + SL      +  A  Y L+++  R+ +  S F
Sbjct: 302 RLMHSLGIDQQKTIESL-QNKSYNHFAAIYFLLVE--RLKSHRSSF 344


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  280 bits (716), Expect = 2e-75
 Identities = 154/375 (41%), Positives = 222/375 (59%), Gaps = 8/375 (2%)

Query: 11  VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70
           +++G Y +  TLG G F  VK+  H++T  +VA+KI+++ ++ S ++  KI RE+Q +KL
Sbjct: 22  LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKL 80

Query: 71  FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130
             HPHIIKLYQV+ T    ++V E+   GE+FDY+  +G + E EAR+ F QILSAV+YC
Sbjct: 81  LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140

Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190
           H H +VHRDLK EN+LLD +M+ K+ADFG  N    GE L T CGSP YAAPEV  G+ Y
Sbjct: 141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEY 200

Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250
            GP++DIWS GV+LY L+CG+LPFD  ++PTL +++  G F IP ++++   +L+  ML 
Sbjct: 201 EGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLV 260

Query: 251 VDPLKRATIKDIREHEWFKQD--LPSYLFP--EDPSYDANVID-DEAVKEVCEKFECTES 305
           VDP +R TI  IR+H W + +  LP    P     SY +N+ D DE    + +       
Sbjct: 261 VDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQ 320

Query: 306 EVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP-PGLK 364
             + SL +       A+ Y L+   +   N        +  P     D S + +P  GL 
Sbjct: 321 RTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLS 380

Query: 365 PHPERMPPLIADSPK 379
             P R P L+   P+
Sbjct: 381 TDPFR-PALLCPQPQ 394


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  275 bits (702), Expect = 1e-73
 Identities = 150/369 (40%), Positives = 220/369 (59%), Gaps = 14/369 (3%)

Query: 13  IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72
           +G Y L  TLG G  G VK+G H +TG KVA+KI+NR+K+ S  V+ K++REI  LKL  
Sbjct: 31  VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 89

Query: 73  HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132
           HPH++KL+ V       ++V+E+VSGGELFDY+ K GR+   EAR+ F+QI+SA+D+CH 
Sbjct: 90  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHS 149

Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192
           + + HRDLKPEN+LLD   N +IADFG++++      L TSCGSP+YA PEVI G  Y G
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDG 209

Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252
              D+WSCGVIL+ALL G LPFDD+++  L +K++ GVF++P ++     +LL  M++V+
Sbjct: 210 RRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVE 269

Query: 253 PLKRATIKDIREHEWF---KQDLPSYLFPED------PSYDANVIDDEAVKEVCEKFEC- 302
           P KR +++ I++H W+   K +    L P         S  +N   D  V E      C 
Sbjct: 270 PEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCF 329

Query: 303 TESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPG 362
            + E ++     + ++Q  + Y+L++D +       +  L   PP             P 
Sbjct: 330 RDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDL---PPRNDVDPPRKRVDSPM 386

Query: 363 LKPHPERMP 371
           L  H +R P
Sbjct: 387 LSRHGKRRP 395


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  273 bits (697), Expect = 4e-73
 Identities = 151/375 (40%), Positives = 223/375 (59%), Gaps = 28/375 (7%)

Query: 13  IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72
           +G Y L  TLG G  G VK+G H +T  KVA+KI+NR+K+ S  V+ K++REI  LKL  
Sbjct: 16  VGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 74

Query: 73  HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132
           HPH++KL+ V       ++V+E+VSGGELFDY+ K GR+   EAR+ F+QI+SA+D+CH 
Sbjct: 75  HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 134

Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192
           H + HRDLKPEN+LLD   N +IADFG++++      L TSCGSP+YA PEVI G  Y G
Sbjct: 135 HSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 194

Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252
            + D+WSCGVIL+ALL G LPFDD+++  L +K++ GVF++P ++     +LL  M++VD
Sbjct: 195 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 254

Query: 253 PLKRATIKDIREHEWF---------KQDLPSYL----FPEDPSYDANVIDDEAVKEVCEK 299
             +R T++ I++H W+         +Q +P  +     P     D +V+D          
Sbjct: 255 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDS------MHS 308

Query: 300 FEC--TESEVMNSLYSGDPQDQLAVAYHLIIDNR-RIMNQASEFYLASSPPSGSFMDDSA 356
             C    ++++  L S + ++Q  + Y L++D + R  +Q  E      PP         
Sbjct: 309 LGCFRDRNKLLQDLLS-EEENQEKMIYFLLLDRKERYPSQEDE----DLPPRNEIDPPRK 363

Query: 357 MHIPPGLKPHPERMP 371
               P L  H +R P
Sbjct: 364 RVDSPMLNRHGKRRP 378


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  271 bits (693), Expect = 1e-72
 Identities = 141/334 (42%), Positives = 207/334 (61%), Gaps = 21/334 (6%)

Query: 12  KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
           +IG+Y +  T+G G F  VK   H +T  KVA+KI+++ ++   + + KI RE+Q +K+ 
Sbjct: 4   RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDE-ENLKKIFREVQIMKML 62

Query: 72  RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
            HPHII+LYQV+ T    ++V EY SGGE+FD++  HGR+ E EARR F+QI++AV +CH
Sbjct: 63  CHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH 122

Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191
              +VHRDLK EN+LLDA++N KIADFG SN+ + G+ L+T CGSP YAAPE+  G+ Y 
Sbjct: 123 CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD 182

Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQV 251
           GP+VDIWS GV+LY L+CG LPFD   +  L  ++  G F IP +++     L+ HML +
Sbjct: 183 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL 242

Query: 252 DPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKE-------------VCE 298
           DP KR +++ I +H+W K      L   DP++D  + + + +KE               E
Sbjct: 243 DPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAME 296

Query: 299 KFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRR 332
                + + + SL S D  D  +  Y L+ D  +
Sbjct: 297 DMGLDKEQTLQSLRS-DAYDHYSAIYSLLCDRHK 329


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  269 bits (688), Expect = 4e-72
 Identities = 155/403 (38%), Positives = 232/403 (57%), Gaps = 20/403 (4%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VA+KI+++ ++    +  K+
Sbjct: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    +++MEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P+KR T++ I +  W      + +L  ++ PE    D   ID      +
Sbjct: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID------I 334

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSA 356
                 ++ E+  SL S    D++   Y L++  +     AS+   +S+         S 
Sbjct: 335 MVGMGYSQEEIQESL-SKMKYDEITATY-LLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392

Query: 357 MHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKK 399
           ++   G  PH  ++   +  S K R   D      P  +A  K
Sbjct: 393 LNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPK 434


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  269 bits (688), Expect = 4e-72
 Identities = 155/403 (38%), Positives = 232/403 (57%), Gaps = 20/403 (4%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VA+KI+++ ++    +  K+
Sbjct: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    +++MEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P+KR T++ I +  W      + +L  ++ PE    D   ID      +
Sbjct: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID------I 334

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSA 356
                 ++ E+  SL S    D++   Y L++  +     AS+   +S+         S 
Sbjct: 335 MVGMGYSQEEIQESL-SKMKYDEITATY-LLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392

Query: 357 MHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKK 399
           ++   G  PH  ++   +  S K R   D      P  +A  K
Sbjct: 393 LNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPK 434


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  269 bits (688), Expect = 4e-72
 Identities = 155/403 (38%), Positives = 232/403 (57%), Gaps = 20/403 (4%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VA+KI+++ ++    +  K+
Sbjct: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    +++MEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P+KR T++ I +  W      + +L  ++ PE    D   ID      +
Sbjct: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID------I 334

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSA 356
                 ++ E+  SL S    D++   Y L++  +     AS+   +S+         S 
Sbjct: 335 MVGMGYSQEEIQESL-SKMKYDEITATY-LLLGRKSSELDASDSSSSSNLSLAKVRPSSD 392

Query: 357 MHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKK 399
           ++   G  PH  ++   +  S K R   D      P  +A  K
Sbjct: 393 LNNSTGQSPH-HKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPK 434


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  267 bits (682), Expect = 2e-71
 Identities = 132/287 (45%), Positives = 190/287 (66%), Gaps = 6/287 (2%)

Query: 8   DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67
           D +  IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++    +  K+ RE++ 
Sbjct: 52  DEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRI 110

Query: 68  LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127
           +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+QI+SAV
Sbjct: 111 MKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAV 170

Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187
            YCH+  +VHRDLK EN+LLD  MN KIADFG SN  + G  L T CGSP YAAPE+  G
Sbjct: 171 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG 230

Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247
           + Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++     LL  
Sbjct: 231 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 290

Query: 248 MLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVID 289
           +L ++P+KR +++ I +  W      +++L  Y  P+    D   ID
Sbjct: 291 LLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRID 337


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  266 bits (680), Expect = 4e-71
 Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++ S  +  K+
Sbjct: 44  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 97

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 98  FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 157

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 158 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E+
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 331

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327
                 T  E+ +SL  G   +++   Y L+
Sbjct: 332 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 361


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  266 bits (680), Expect = 4e-71
 Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++ S  +  K+
Sbjct: 44  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 97

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 98  FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 157

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 158 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E+
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 331

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327
                 T  E+ +SL  G   +++   Y L+
Sbjct: 332 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 361


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  266 bits (680), Expect = 4e-71
 Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++ S  +  K+
Sbjct: 44  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 97

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 98  FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 157

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 158 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E+
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 331

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327
                 T  E+ +SL  G   +++   Y L+
Sbjct: 332 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 361


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  266 bits (680), Expect = 4e-71
 Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++ S  +  K+
Sbjct: 44  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 97

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 98  FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 157

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 158 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 217

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 218 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 277

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E+
Sbjct: 278 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 331

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327
                 T  E+ +SL  G   +++   Y L+
Sbjct: 332 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 361


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  266 bits (680), Expect = 4e-71
 Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VAVKI+++ ++ S  +  K+
Sbjct: 11  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KL 64

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    ++VMEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 65  FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 124

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 125 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 184

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 185 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 244

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P KR T++ I +  W        +L  Y+ P  P Y      D    E+
Sbjct: 245 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 298

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327
                 T  E+ +SL  G   +++   Y L+
Sbjct: 299 MVSMGYTREEIQDSLV-GQRYNEVMATYLLL 328


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  266 bits (679), Expect = 5e-71
 Identities = 141/331 (42%), Positives = 207/331 (62%), Gaps = 18/331 (5%)

Query: 2   AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61
           A++Q H     IG+Y L  T+G G F KVK+  H LTG +VA+KI+++ ++    +  K+
Sbjct: 47  ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KL 100

Query: 62  KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121
            RE++ +K+  HP+I+KL++VI T    +++MEY SGGE+FDY+  HGR++E EAR  F+
Sbjct: 101 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 160

Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           QI+SAV YCH+  +VHRDLK EN+LLDA MN KIADFG SN  + G  L T CGSP YAA
Sbjct: 161 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 220

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE+  G+ Y GPEVD+WS GVILY L+ G+LPFD +++  L +++  G + IP Y++   
Sbjct: 221 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 280

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEV 296
             LL   L ++P+KR T++ I +  W      + +L  ++ PE    D   ID      +
Sbjct: 281 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID------I 334

Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327
                 ++ E+  SL S    D++   Y L+
Sbjct: 335 MVGMGYSQEEIQESL-SKMKYDEITATYLLL 364


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  259 bits (661), Expect = 6e-69
 Identities = 138/316 (43%), Positives = 196/316 (62%), Gaps = 17/316 (5%)

Query: 3   EKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK 62
           E+Q H     +G+Y L  T+G G F KVK+  H LTG +VA+KI+++ ++    +  K+ 
Sbjct: 51  EEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLF 104

Query: 63  REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ 122
           RE++ +K   HP+I+KL++VI T    ++VMEY S GE+FDY+  HGR++E EAR  F+Q
Sbjct: 105 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQ 164

Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182
           I+SAV YCH+  +VHRDLK EN+LLDA  N KIADFG SN  + G  L T CGSP YAAP
Sbjct: 165 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAP 224

Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA 242
           E+  G+ Y GPEVDIWS GVILY L+ G+LPFD  ++  L +++  G + +P Y++    
Sbjct: 225 ELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCE 284

Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEVC 297
           ++L   L ++P KR T++ I + +W       ++L  Y  PE+   D   I      EV 
Sbjct: 285 SILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRI------EVM 338

Query: 298 EKFECTESEVMNSLYS 313
                T  E+  SL S
Sbjct: 339 VGMGYTREEIKESLTS 354


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  249 bits (636), Expect = 5e-66
 Identities = 140/318 (44%), Positives = 191/318 (60%), Gaps = 10/318 (3%)

Query: 15  HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74
           +Y L +T+G G F KVK+  H LTG  VA+KI+++  + S   + +IK EI+ LK  RH 
Sbjct: 10  YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQ 67

Query: 75  HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134
           HI +LY V+ T    FMV+EY  GGELFDYI    R+ E E R +F+QI+SAV Y H   
Sbjct: 68  HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 127

Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSPNYAAPEVISGRLYAG 192
             HRDLKPEN+L D +   K+ DFGL       +   L+T CGS  YAAPE+I G+ Y G
Sbjct: 128 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLG 187

Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252
            E D+WS G++LY L+CG LPFDD++V  L+KKI  G + +P++L+ S   LL  MLQVD
Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVD 247

Query: 253 PLKRATIKDIREHEWFKQDLPSYLFP-EDPSYDANV-IDDEAVKEVCEKFECTESEVMNS 310
           P KR ++K++  H W  QD   Y +P E  S +  + +DD+ V E+         + M  
Sbjct: 248 PKKRISMKNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTELSVHHR-NNRQTMED 303

Query: 311 LYSGDPQDQLAVAYHLII 328
           L S    D L   Y L++
Sbjct: 304 LISLWQYDHLTATYLLLL 321


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  241 bits (615), Expect = 1e-63
 Identities = 125/282 (44%), Positives = 176/282 (62%), Gaps = 2/282 (0%)

Query: 5   QKHDGRVKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63
           ++H  +  + H Y L +TLG GT+GKVK    + +G  VA+K + + KI+    +  I+R
Sbjct: 43  KRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRR 102

Query: 64  EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123
           EI+ +    HPHII +Y+V        ++MEY S GEL+DYI +  R+ E E R  F+QI
Sbjct: 103 EIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQI 162

Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183
           +SAV YCH++ VVHRDLK EN+LLD + N KIADFGLSN+    +FL+T CGSP YA+PE
Sbjct: 163 VSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPE 222

Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243
           +++GR Y GPEVD W+ GV+LY L+ GT+PFD      L ++I  G +  P   +     
Sbjct: 223 IVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARG 281

Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 285
           L+  ML V+P +RATI+DI  H W      S +   D  +D+
Sbjct: 282 LIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDS 323


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score =  236 bits (603), Expect = 3e-62
 Identities = 120/264 (45%), Positives = 173/264 (65%), Gaps = 3/264 (1%)

Query: 5   QKHDGRVKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63
           ++H  +  + H Y   +TLG GT+GKVK    + +G  VA+K + + KI+    +  I+R
Sbjct: 41  KRHHHKHNLRHRYEFLETLGKGTYGKVK-KARESSGRLVAIKSIRKDKIKDEQDLMHIRR 99

Query: 64  EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123
           EI+ +    HPHII +++V    +   +VMEY S G+L+DYI +  ++ E EAR  F+QI
Sbjct: 100 EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQI 159

Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183
           +SAV YCH++ VVHRDLK EN+LLDA+ N KIADFGLSN+   G+FL+T CGSP YA+PE
Sbjct: 160 VSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPE 219

Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243
           +++G+ Y GPEVD WS GV+LY L+ GT+PFD      L K+I  G +  P   +     
Sbjct: 220 IVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPS-DACG 278

Query: 244 LLMHMLQVDPLKRATIKDIREHEW 267
           L+  +L V+P +RAT++D+  H W
Sbjct: 279 LIRWLLMVNPTRRATLEDVASHWW 302


>gi|156105707 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  221 bits (562), Expect = 2e-57
 Identities = 114/273 (41%), Positives = 170/273 (62%), Gaps = 4/273 (1%)

Query: 4   KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63
           K+ +DG++  G Y L  TLG G F  VK+  H  TG KVAVK++++ K+ +L   G + +
Sbjct: 5   KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62

Query: 64  EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQ 122
           E++ +KL +HP+I++LY+VI T T  ++++E   GG++FDYI KH   + E  A++ F Q
Sbjct: 63  EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122

Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           I+ A+ YCH+  VVHRDLKPENV+        K+ DFG SN    G+ L TSCGS  Y+A
Sbjct: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 182

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE++ G  Y  P VDIWS GVIL+ L+CG  PF + +       I    + +P ++++  
Sbjct: 183 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKEC 242

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274
             L+  MLQ DP +RA++++I  H W +   PS
Sbjct: 243 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPS 275


>gi|156105705 SNF related kinase [Homo sapiens]
          Length = 765

 Score =  221 bits (562), Expect = 2e-57
 Identities = 114/273 (41%), Positives = 170/273 (62%), Gaps = 4/273 (1%)

Query: 4   KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63
           K+ +DG++  G Y L  TLG G F  VK+  H  TG KVAVK++++ K+ +L   G + +
Sbjct: 5   KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 62

Query: 64  EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQ 122
           E++ +KL +HP+I++LY+VI T T  ++++E   GG++FDYI KH   + E  A++ F Q
Sbjct: 63  EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 122

Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAA 181
           I+ A+ YCH+  VVHRDLKPENV+        K+ DFG SN    G+ L TSCGS  Y+A
Sbjct: 123 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 182

Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241
           PE++ G  Y  P VDIWS GVIL+ L+CG  PF + +       I    + +P ++++  
Sbjct: 183 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKEC 242

Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274
             L+  MLQ DP +RA++++I  H W +   PS
Sbjct: 243 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPS 275


>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
          Length = 436

 Score =  213 bits (542), Expect = 4e-55
 Identities = 120/324 (37%), Positives = 179/324 (55%), Gaps = 9/324 (2%)

Query: 12  KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71
           +IG Y +   +G G F +VK+G H LT  KVA+KIL++ K+        + REI +++  
Sbjct: 70  RIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQ-KTQRLLSREISSMEKL 128

Query: 72  RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131
            HP+II+LY+V+ T +   +VMEY  GGELF  I   G++ E E++ +F QI+SAV + H
Sbjct: 129 HHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMH 188

Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191
            + ++HRDLK ENV   ++   K+ DFG S +   GE L T CGSP YAAPE+     Y 
Sbjct: 189 ENQIIHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYI 248

Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQV 251
           G  VDIW+ GV+LY ++ GT+PF  E V  L K I  G + +P +++     L+  +LQ 
Sbjct: 249 GIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQ 308

Query: 252 DPLKRATIKDIREHEWFK---QDLPSYLFPEDPSY--DANVIDDE--AVKEVCEKFECTE 304
            P +R  I  I   EW +      P   F  DP +  + + + +E   VK   E    TE
Sbjct: 309 IPTERYGIDCIMNDEWMQGVPYPTPLEPFQLDPKHLSETSTLKEEENEVKSTLEHLGITE 368

Query: 305 SEVMNSLYSGDPQDQLAVAYHLII 328
             + N+    D +  +   Y +I+
Sbjct: 369 EHIRNN-QGRDARSSITGVYRIIL 391


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  203 bits (517), Expect = 3e-52
 Identities = 123/344 (35%), Positives = 201/344 (58%), Gaps = 22/344 (6%)

Query: 12  KIGHYVLGDT-LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLK 69
           ++G+Y++G   LG G+F KV+ G H LTG KVA+K++++++ +    V K ++RE Q  +
Sbjct: 57  RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116

Query: 70  LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129
           + RHP+I +L  ++ T   +++VME   GG L   I +  R+EE EARR  +Q++SAV++
Sbjct: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176

Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVIS 186
            HR  VVHRDLK EN+LLD   N K+ DFGLSN   ++   +   T CGSP YAAPE+++
Sbjct: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236

Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDE--HVPTLFKK-IRGGVFYIPEYLNRSVAT 243
            + Y GP++D+WS GV +YA+L GTLPF  E   +  L++K +   +  +P  L+    +
Sbjct: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295

Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANV----IDDEAVKEVCEK 299
            L  +L+ DP+KR  I+    + W  ++    + P + +Y   +    +    V  + EK
Sbjct: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKV-PCNVTYPNRISLEDLSPSVVLHMTEK 354

Query: 300 FECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLA 343
                S+V+N++ S      LA+ +        ++N+  E YL+
Sbjct: 355 LGYKNSDVINTVLSNRACHILAIYF--------LLNKKLERYLS 390


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  178 bits (452), Expect = 1e-44
 Identities = 99/259 (38%), Positives = 147/259 (56%), Gaps = 10/259 (3%)

Query: 20  DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79
           +TLG G F +V + E + TG   AVK + ++ ++  +    I+ EI  L+  +H +I+ L
Sbjct: 27  ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE--SSIENEIAVLRKIKHENIVAL 84

Query: 80  YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139
             +  +P   ++VM+ VSGGELFD I + G   E +A  L +Q+L AV Y HR  +VHRD
Sbjct: 85  EDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRD 144

Query: 140 LKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196
           LKPEN+L    D      I+DFGLS M   G+ + T+CG+P Y APEV++ + Y+   VD
Sbjct: 145 LKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYS-KAVD 203

Query: 197 IWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMHMLQVD 252
            WS GVI Y LLCG  PF DE+   LF++I    +       + ++ S    + ++++ D
Sbjct: 204 CWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKD 263

Query: 253 PLKRATIKDIREHEWFKQD 271
           P KR T +    H W   D
Sbjct: 264 PNKRYTCEQAARHPWIAGD 282


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  178 bits (452), Expect = 1e-44
 Identities = 99/259 (38%), Positives = 147/259 (56%), Gaps = 10/259 (3%)

Query: 20  DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79
           +TLG G F +V + E + TG   AVK + ++ ++  +    I+ EI  L+  +H +I+ L
Sbjct: 27  ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE--SSIENEIAVLRKIKHENIVAL 84

Query: 80  YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139
             +  +P   ++VM+ VSGGELFD I + G   E +A  L +Q+L AV Y HR  +VHRD
Sbjct: 85  EDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRD 144

Query: 140 LKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196
           LKPEN+L    D      I+DFGLS M   G+ + T+CG+P Y APEV++ + Y+   VD
Sbjct: 145 LKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYS-KAVD 203

Query: 197 IWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMHMLQVD 252
            WS GVI Y LLCG  PF DE+   LF++I    +       + ++ S    + ++++ D
Sbjct: 204 CWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKD 263

Query: 253 PLKRATIKDIREHEWFKQD 271
           P KR T +    H W   D
Sbjct: 264 PNKRYTCEQAARHPWIAGD 282


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  177 bits (448), Expect = 3e-44
 Identities = 101/263 (38%), Positives = 146/263 (55%), Gaps = 10/263 (3%)

Query: 16  YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75
           Y   D LG G F +V + E + T   VA+K + ++ +   +  G ++ EI  L   +HP+
Sbjct: 20  YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE--GSMENEIAVLHKIKHPN 77

Query: 76  IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135
           I+ L  +  +    +++M+ VSGGELFD I + G   E +A RL  Q+L AV Y H   +
Sbjct: 78  IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137

Query: 136 VHRDLKPENVL---LDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192
           VHRDLKPEN+L   LD      I+DFGLS M   G  L T+CG+P Y APEV++ + Y+ 
Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYS- 196

Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMHM 248
             VD WS GVI Y LLCG  PF DE+   LF++I    +       + ++ S    + H+
Sbjct: 197 KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHL 256

Query: 249 LQVDPLKRATIKDIREHEWFKQD 271
           ++ DP KR T +   +H W   D
Sbjct: 257 MEKDPEKRFTCEQALQHPWIAGD 279


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score =  173 bits (438), Expect = 4e-43
 Identities = 97/263 (36%), Positives = 146/263 (55%), Gaps = 11/263 (4%)

Query: 16  YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75
           Y + + LG G F +V + + + + H VA+K + ++ +R  + +  ++ EI  L+   HP+
Sbjct: 32  YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEAL--VENEIAVLRRISHPN 89

Query: 76  IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135
           I+ L  V  +P+  ++ ME V+GGELFD I + G   E +A  L  Q+L AV Y H   +
Sbjct: 90  IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGI 149

Query: 136 VHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192
           VHRDLKPEN+L           ++DFGLS + + G  L T+CG+P Y APE++  + Y G
Sbjct: 150 VHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPELLEQKPY-G 207

Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMHM 248
             VD+W+ GVI Y LLCG  PF DE  P LF +I    +       + ++ S    + H+
Sbjct: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267

Query: 249 LQVDPLKRATIKDIREHEWFKQD 271
           L+ DP KR T +    H W   D
Sbjct: 268 LERDPQKRFTCQQALRHLWISGD 290


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,235,258
Number of Sequences: 37866
Number of extensions: 961021
Number of successful extensions: 5321
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 733
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 2889
Number of HSP's gapped (non-prelim): 1039
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.