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Search of human proteins with 46094081
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
(1129 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46094081 development and differentiation enhancing factor 1 [... 2272 0.0
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 1128 0.0
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 1058 0.0
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 744 0.0
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 710 0.0
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 185 2e-46
gi|187608516 centaurin, beta 2 [Homo sapiens] 180 8e-45
gi|7661880 centaurin beta1 [Homo sapiens] 165 2e-40
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 130 5e-30
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 130 7e-30
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 129 1e-29
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 129 1e-29
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 127 5e-29
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 127 6e-29
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 126 1e-28
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 124 7e-28
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 122 1e-27
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 122 1e-27
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 119 2e-26
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 118 3e-26
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 117 6e-26
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 95 4e-19
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 95 4e-19
gi|23943872 small ArfGAP2 [Homo sapiens] 89 3e-17
gi|113204622 stromal membrane-associated GTPase-activating prote... 88 5e-17
gi|21264558 stromal membrane-associated GTPase-activating protei... 86 2e-16
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 86 3e-16
gi|6806913 centaurin, alpha 1 [Homo sapiens] 85 3e-16
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 83 2e-15
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 81 6e-15
>gi|46094081 development and differentiation enhancing factor 1 [Homo
sapiens]
Length = 1129
Score = 2272 bits (5888), Expect = 0.0
Identities = 1129/1129 (100%), Positives = 1129/1129 (100%)
Query: 1 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 60
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
Sbjct: 1 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 60
Query: 61 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 120
EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
Sbjct: 61 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 120
Query: 121 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 180
FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
Sbjct: 121 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 180
Query: 181 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 240
EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
Sbjct: 181 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 240
Query: 241 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 300
IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
Sbjct: 241 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 300
Query: 301 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT 360
QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT
Sbjct: 301 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT 360
Query: 361 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT 420
SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT
Sbjct: 361 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT 420
Query: 421 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI 480
MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI
Sbjct: 421 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI 480
Query: 481 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK 540
HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK
Sbjct: 481 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK 540
Query: 541 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL 600
EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL
Sbjct: 541 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL 600
Query: 601 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK 660
GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK
Sbjct: 601 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK 660
Query: 661 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD 720
PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD
Sbjct: 661 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD 720
Query: 721 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST 780
LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST
Sbjct: 721 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST 780
Query: 781 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD 840
DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD
Sbjct: 781 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD 840
Query: 841 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK 900
PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK
Sbjct: 841 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK 900
Query: 901 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG 960
VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG
Sbjct: 901 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG 960
Query: 961 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK 1020
ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK
Sbjct: 961 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK 1020
Query: 1021 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA 1080
SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA
Sbjct: 1021 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA 1080
Query: 1081 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1129
DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
Sbjct: 1081 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1129
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 1128 bits (2918), Expect = 0.0
Identities = 620/1117 (55%), Positives = 747/1117 (66%), Gaps = 119/1117 (10%)
Query: 21 MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKA 80
MPDQISVSEF+AET EDY +PT SSFTTR CRNTV +EEALD DR L K+KKSVKA
Sbjct: 1 MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA 60
Query: 81 IYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLS 140
I +SG HV+NEE Y Q L+KFG N + RD+PDLG+AF+KFS TKEL+ L KNL+Q ++
Sbjct: 61 INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN 120
Query: 141 HNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITG 200
+ + F LDSLLKGDLKGVKGDLKKPFDKAWKDYETK TKIEKEK+EHAK HGMIRTEI+G
Sbjct: 121 NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG 180
Query: 201 AEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADK 260
AEIAEEMEKERR FQLQMCEYL+KVNEIK KKGVDLLQNLIKY+HAQCNFFQDGLK +
Sbjct: 181 AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES 240
Query: 261 LKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQG-GYSMHQLQG 319
LK IE L+ DL+ IKQ QDEE++QL LRD++KS+LQ++QKEDSQ RQ YS+HQ QG
Sbjct: 241 LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG 300
Query: 320 NKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNA 379
NKE+G+E+ G L KKSDGIRKVWQ+RKCSVKNG LTISH T+NR PAKLNLLTCQVK N
Sbjct: 301 NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP 360
Query: 380 EDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSL-EDLT 438
E+KK FDLISH+RTYHFQAEDEQ+ W+SVL NSKEEAL AF+G+ + GEN++ ++LT
Sbjct: 361 EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT 420
Query: 439 KAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDK 498
K II +VQR+ GND+CCDCG+ +PTWLSTNLGILTCIECSGIHRE+GVH SR+QSL LD
Sbjct: 421 KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV 480
Query: 499 LGTSELLLAKNVGNNSFNDIMEANLPSP-SPKPTPSSDMTVRKEYITAKYVDHRFSRKTC 557
LGTSELLLAKN+GN FN+IME LP+ S KP P SDM RK+YITAKY++ R++RK
Sbjct: 481 LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
Query: 558 STSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPL-LEPGQELGETALHLAVRTADQTS 616
+ ++AKL+ L EA+K+RD+ L+Q YA+GV+L E + L G E ETALHLAVR+ D+TS
Sbjct: 541 ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS 600
Query: 617 LHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDI 676
LH+VDFLVQN GNLDKQT G+T LHYC + ECLKLLLR K +++I N++GET LDI
Sbjct: 601 LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI 660
Query: 677 AKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRP 736
AKRLK CE+LL+QA SG+FN HVHVEYEW L E++DESDDD+D+K P R RP
Sbjct: 661 AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP 720
Query: 737 QSFCHSSSISPQDK---LALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPL 793
SF S Q LA + ++KQR
Sbjct: 721 ISFYQLGSNQLQSNAVSLARDAANLAKEKQR----------------------------- 751
Query: 794 PPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKG 853
+ +P Q + + LS PPP P T S PP P P N G
Sbjct: 752 -------------AFMPSILQNETYGALLSGS-PPPAQPAAPSTTSAPPLP----PRNVG 793
Query: 854 AVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDK 913
V +SS+ T K +S + ++ P V P LP LR T L
Sbjct: 794 KVQ------TASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPP---LRVTSTNPLTP 844
Query: 914 ATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPP 973
T PP + + S + L Q P KP PP ++ P P LPP
Sbjct: 845 -TPPPPVAKTPSVMEALSQ-------PSKPA-----------PPGISQIRPPP----LPP 881
Query: 974 KPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSR 1033
+P S LP K KP +P A + + +T K P R
Sbjct: 882 QPP-SRLPQK--------KP--------------APGADKSTPLTNKGQP---------R 909
Query: 1034 DAIQKQASEDSNDLTPTLP-ETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGE 1092
+ A+E L+ + + P P+PRK K K +RVK +Y+C ADN DELTF EG+
Sbjct: 910 GPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGD 969
Query: 1093 VIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1129
VIIV GEEDQEWWIGHI+G P RKG FPVSFVH ++D
Sbjct: 970 VIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD 1006
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 1058 bits (2735), Expect = 0.0
Identities = 556/898 (61%), Positives = 660/898 (73%), Gaps = 48/898 (5%)
Query: 21 MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKA 80
MPDQISVSEF+AET EDY +PT SSFTTR CRNTV +EEALD DR L K+KKSVKA
Sbjct: 1 MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA 60
Query: 81 IYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLS 140
I +SG HV+NEE Y Q L+KFG N + RD+PDLG+AF+KFS TKEL+ L KNL+Q ++
Sbjct: 61 INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN 120
Query: 141 HNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITG 200
+ + F LDSLLKGDLKGVKGDLKKPFDKAWKDYETK TKIEKEK+EHAK HGMIRTEI+G
Sbjct: 121 NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG 180
Query: 201 AEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADK 260
AEIAEEMEKERR FQLQMCEYL+KVNEIK KKGVDLLQNLIKY+HAQCNFFQDGLK +
Sbjct: 181 AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES 240
Query: 261 LKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQG-GYSMHQLQG 319
LK IE L+ DL+ IKQ QDEE++QL LRD++KS+LQ++QKEDSQ RQ YS+HQ QG
Sbjct: 241 LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG 300
Query: 320 NKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNA 379
NKE+G+E+ G L KKSDGIRKVWQ+RKCSVKNG LTISH T+NR PAKLNLLTCQVK N
Sbjct: 301 NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP 360
Query: 380 EDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSL-EDLT 438
E+KK FDLISH+RTYHFQAEDEQ+ W+SVL NSKEEAL AF+G+ + GEN++ ++LT
Sbjct: 361 EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT 420
Query: 439 KAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDK 498
K II +VQR+ GND+CCDCG+ +PTWLSTNLGILTCIECSGIHRE+GVH SR+QSL LD
Sbjct: 421 KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV 480
Query: 499 LGTSELLLAKNVGNNSFNDIMEANLPS-PSPKPTPSSDMTVRKEYITAKYVDHRFSRKTC 557
LGTSELLLAKN+GN FN+IME LP+ S KP P SDM RK+YITAKY++ R++RK
Sbjct: 481 LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
Query: 558 STSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPL-LEPGQELGETALHLAVRTADQTS 616
+ ++AKL+ L EA+K+RD+ L+Q YA+GV+L E + L G E ETALHLAVR+ D+TS
Sbjct: 541 ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS 600
Query: 617 LHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDI 676
LH+VDFLVQN GNLDKQT G+T LHYC + ECLKLLLR K +++I N++GET LDI
Sbjct: 601 LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI 660
Query: 677 AKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRP 736
AKRLK CE+LL+QA SG+FN HVHVEYEW L E++DESDDD+D+K P R RP
Sbjct: 661 AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP 720
Query: 737 QSFCHSSSISPQD---KLALPGFSTPRDKQRL---------SYGAFTNQIFVSTSTDSPT 784
SF S Q LA + ++KQR +YGA + S P
Sbjct: 721 ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSG---SPPPAQPA 777
Query: 785 SP-TTEAPPLPPRNAGKGPTGP---------PSTLPLSTQTSSGSST-LSKKRPPPPPPG 833
+P TT APPLPPRN GK P P PS + +Q S + +S+ RPPP PP
Sbjct: 778 APSTTSAPPLPPRNVGKDPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPP- 836
Query: 834 HKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGP 891
PPS LP P GA S+ TNK G + SA ALGP
Sbjct: 837 ------QPPSRLPQKKPAPGA---------DKSTPLTNK--GQPRGPVDLSATEALGP 877
Score = 134 bits (337), Expect = 5e-31
Identities = 85/225 (37%), Positives = 109/225 (48%), Gaps = 31/225 (13%)
Query: 918 PEIFQKSSQLAELPQKPPPGD--------LPPKPTELAPKPQIGDLPPKPGELPPKPQLG 969
P I Q + A L PPP PP P K + PP P P
Sbjct: 755 PSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKDPLTPTPPPPVAKTPSVMEA 814
Query: 970 ----DLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLD 1025
P P +S + P P LPP+P ++ +P A + + +T K P
Sbjct: 815 LSQPSKPAPPGISQIRPPP----LPPQPP-----SRLPQKKPAPGADKSTPLTNKGQP-- 863
Query: 1026 LSPNVQSRDAIQKQASEDSNDLTPTLP-ETPVPLPRKINTGKNKVRRVKTIYDCQADNDD 1084
R + A+E L+ + + P P+PRK K K +RVK +Y+C ADN D
Sbjct: 864 -------RGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPD 916
Query: 1085 ELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1129
ELTF EG+VIIV GEEDQEWWIGHI+G P RKG FPVSFVH ++D
Sbjct: 917 ELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD 961
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 744 bits (1922), Expect = 0.0
Identities = 409/879 (46%), Positives = 571/879 (64%), Gaps = 60/879 (6%)
Query: 21 MPDQISVSEFIAETTEDYNSPT-TSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVK 79
MP+Q SV+EF+A T ED +SP ++F ++ R EE L+ D+ LQ++KK+V+
Sbjct: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
Query: 80 AIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGL 139
AI++SG HV+NEE Y + ++ G++ LS+++ +L T F+ + T+E++ L KNL+Q L
Sbjct: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
Query: 140 SHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEIT 199
++ V F LDSL+KG L+ + D KK +KAWKDYE K K+EKE R+ A+ G I
Sbjct: 121 NNIVSFPLDSLMKGQLRDGRQDSKKQLEKAWKDYEAKMAKLEKE-RDRARVTGGIP---- 175
Query: 200 GAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTAD 259
E+A++M++ERR+FQL MCEYL+K E + K+G D LQ+LIK++HAQ NFFQDG K A
Sbjct: 176 -GEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQ 234
Query: 260 KLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQG---GYSMHQ 316
L +IEKLAA ++ + Q Q++E ++LT LRD ++ +LQL+ +E+ SR+ GYS+HQ
Sbjct: 235 SLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQ 294
Query: 317 LQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVK 376
QGNK++G+EK G+L KKSDGIR+VWQ+RKC VK G LTISH+T NR P KL LLTCQV+
Sbjct: 295 HQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVR 354
Query: 377 PNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSL-- 434
PN E+KK FDL++HNRTYHFQAEDE + AW+SVL NSK+EAL+ AF GE SAG S
Sbjct: 355 PNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 414
Query: 435 -------EDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVH 487
DLTK +I +V+ PGN CCDCG+++PTWLSTNLG+LTCI+CSG+HRE+GV
Sbjct: 415 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 474
Query: 488 ISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPS-PSPKPTPSSDMTVRKEYITAK 546
SR+QSL LD LG SELLLA N+GN SFN++MEA LPS PKP+ SDM R++YI AK
Sbjct: 475 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 534
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
YV+HRF+R+ C+ + L AI +RDLL++++ +A G + +PL P Q E L
Sbjct: 535 YVEHRFARR-CTPEPQR---LWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVL 590
Query: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDI 665
HLAV+ A+Q SL LVDF++QN G+LD + A GNT LHY ++Y++P+CLKLLL+ + V
Sbjct: 591 HLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGT 650
Query: 666 VNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKP 725
VN+AGETALDIA++ +CE+LL QA++G F +HV+Y W + E +S++D ++K
Sbjct: 651 VNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKR 710
Query: 726 SPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTS 785
+K S S + +A G +TP+ + S D P
Sbjct: 711 CLLKLPAQAHWASGRLDISNKTYETVASLGAATPQGE----------------SEDCP-- 752
Query: 786 PTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPP-GHKRTLSDPPSP 844
PPLP +N+ + T ++ S S+LS + P P G + S SP
Sbjct: 753 -----PPLPVKNSSR--TLVQGCARHASGDRSEVSSLSSEAPETPESLGSPASSSSLMSP 805
Query: 845 LPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTS 883
L G P++ P +S + + G S+ S TS
Sbjct: 806 LEPGDPSQ---------APPNSEEGLREPPGTSRPSLTS 835
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 710 bits (1833), Expect = 0.0
Identities = 399/879 (45%), Positives = 561/879 (63%), Gaps = 69/879 (7%)
Query: 21 MPDQISVSEFIAETTEDYNSPT-TSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVK 79
MP+Q SV+EF+A T ED +SP ++F ++ R EE L+ D+ LQ++KK+V+
Sbjct: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
Query: 80 AIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGL 139
AI++SG HV+NEE Y + ++ G++ LS+++ +L T F+ + T+E++ L KNL+Q L
Sbjct: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
Query: 140 SHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEIT 199
++ V F LDSL+KG L+ + +A K+EKE R+ A+ G I
Sbjct: 121 NNIVSFPLDSLMKGQLRDGRQASLSLGSRA---------KLEKE-RDRARVTGGIP---- 166
Query: 200 GAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTAD 259
E+A++M++ERR+FQL MCEYL+K E + K+G D LQ+LIK++HAQ NFFQDG K A
Sbjct: 167 -GEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQ 225
Query: 260 KLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQG---GYSMHQ 316
L +IEKLAA ++ + Q Q++E ++LT LRD ++ +LQL+ +E+ SR+ GYS+HQ
Sbjct: 226 SLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQ 285
Query: 317 LQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVK 376
QGNK++G+EK G+L KKSDGIR+VWQ+RKC VK G LTISH+T NR P KL LLTCQV+
Sbjct: 286 HQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVR 345
Query: 377 PNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSL-- 434
PN E+KK FDL++HNRTYHFQAEDE + AW+SVL NSK+EAL+ AF GE SAG S
Sbjct: 346 PNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 405
Query: 435 -------EDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVH 487
DLTK +I +V+ PGN CCDCG+++PTWLSTNLG+LTCI+CSG+HRE+GV
Sbjct: 406 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 465
Query: 488 ISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPS-PSPKPTPSSDMTVRKEYITAK 546
SR+QSL LD LG SELLLA N+GN SFN++MEA LPS PKP+ SDM R++YI AK
Sbjct: 466 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 525
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
YV+HRF+R+ C+ + L AI +RDLL++++ +A G + +PL P Q E L
Sbjct: 526 YVEHRFARR-CTPEPQR---LWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVL 581
Query: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDI 665
HLAV+ A+Q SL LVDF++QN G+LD + A GNT LHY ++Y++P+CLKLLL+ + V
Sbjct: 582 HLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGT 641
Query: 666 VNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKP 725
VN+AGETALDIA++ +CE+LL QA++G F +HV+Y W + E +S++D ++K
Sbjct: 642 VNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEKR 701
Query: 726 SPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTS 785
+K S S + +A G +TP+ + S D P
Sbjct: 702 CLLKLPAQAHWASGRLDISNKTYETVASLGAATPQGE----------------SEDCP-- 743
Query: 786 PTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPP-GHKRTLSDPPSP 844
PPLP +N+ + T ++ S S+LS + P P G + S SP
Sbjct: 744 -----PPLPVKNSSR--TLVQGCARHASGDRSEVSSLSSEAPETPESLGSPASSSSLMSP 796
Query: 845 LPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTS 883
L G P++ P +S + + G S+ S TS
Sbjct: 797 LEPGDPSQ---------APPNSEEGLREPPGTSRPSLTS 826
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 185 bits (469), Expect = 2e-46
Identities = 138/523 (26%), Positives = 239/523 (45%), Gaps = 39/523 (7%)
Query: 54 RNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPD 113
R T+ +E + + L K+ K + +G+ +V + + + +
Sbjct: 16 RATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQ--CQGDTV 73
Query: 114 LGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDY 173
+ +F+ +E+ L +V L S +K D++ K + KK FDK +D
Sbjct: 74 ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFK-ETKKQFDKVREDL 132
Query: 174 ETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKG 233
E + + R + E TGA + R+ F+ +Y++++N ++ KK
Sbjct: 133 ELSLVRNAQAPRHRPHEV----EEATGA-----LTLTRKCFRHLALDYVLQINVLQAKKK 183
Query: 234 VDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLI 293
++L +++ + HAQ +FFQ G +L Y++KLAA+L + EK+++ I
Sbjct: 184 FEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAI 243
Query: 294 KSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGI 353
+ L +S+ + + G +GYL K++ K W RR S++N
Sbjct: 244 QQRTLLQDFSYDESKV------EFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQ 297
Query: 354 LTISHATSNRQPAKLN-LLTCQVKP--NAEDKKSFDLISHNRTYHFQAEDEQDYVAWI-- 408
L + ++ L C VKP + E + F+++S ++ QA+ E+ AW+
Sbjct: 298 LVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQA 357
Query: 409 ------SVLTNSKEEALTMAFRGEQSAGENSLEDLT---------KAIIEDVQRLPGNDI 453
S S + + S +S++ T +++++ VQ + GN
Sbjct: 358 VQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQ 417
Query: 454 CCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNN 513
C DCG +P W S NLG+L CIECSGIHR +GVH S+++SL LD L L +GN+
Sbjct: 418 CGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNS 477
Query: 514 SFNDIMEANLP-SPSPKPTPSSDMTVRKEYITAKYVDHRFSRK 555
+ N I EA + S KPT SS ++ +I KYV+ +F RK
Sbjct: 478 AVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRK 520
Score = 34.7 bits (78), Expect = 0.53
Identities = 32/124 (25%), Positives = 57/124 (45%), Gaps = 6/124 (4%)
Query: 570 AIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGN 629
A ++RDL AL A G E+ ++ G+T L AV SL + +FL+QN +
Sbjct: 675 AARARDLPALAAALAHGAEVN---WADAEDEGKTPLVQAVLGG---SLIVCEFLLQNGAD 728
Query: 630 LDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLL 689
++++ + G LH+ ++ + + L L+ ++Q L IA + LL
Sbjct: 729 VNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLL 788
Query: 690 SQAK 693
A+
Sbjct: 789 RLAR 792
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 180 bits (456), Expect = 8e-45
Identities = 129/458 (28%), Positives = 213/458 (46%), Gaps = 38/458 (8%)
Query: 116 TAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYET 175
T+ KFS +E+ L ++ L + +K DL+ K D KK F+K ++ E
Sbjct: 78 TSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFK-DAKKQFEKVSEEKEN 136
Query: 176 KFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVD 235
K + +R KQH + E + R+ F+ +Y++++N +++K+ +
Sbjct: 137 ALVKNAQVQRN--KQHEV-------EEATNILTATRKCFRHIALDYVLQINVLQSKRRSE 187
Query: 236 LLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKS 295
+L++++ + +A FF G +L Y++ L A L + +EK+++ I
Sbjct: 188 ILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTI-- 245
Query: 296 SLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILT 355
Q++D S + N G +GYL K++ K W RR S++N L
Sbjct: 246 -----QQKDFSSDDSKLEYNVDAAN---GIVMEGYLFKRASNAFKTWNRRWFSIQNNQLV 297
Query: 356 ISHATSNRQPAKL-NLLTCQVK--PNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLT 412
+ + +L C VK + E + F+++S ++ QA+ E+ AWI +
Sbjct: 298 YQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQ 357
Query: 413 NS-------------KEEALTMAFRGEQSAGENSLEDLTK--AIIEDVQRLPGNDICCDC 457
S K + + G +G S E L K + ++ VQ +PGN CCDC
Sbjct: 358 TSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDC 417
Query: 458 GSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFND 517
G ++P W S NLGI CIECSGIHR +GVH S+++SL LD L L +GN+ N
Sbjct: 418 GLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINR 477
Query: 518 IMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRK 555
+ EAN+ K ++ YI AKYV+ +F K
Sbjct: 478 VYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDK 515
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 165 bits (418), Expect = 2e-40
Identities = 152/704 (21%), Positives = 284/704 (40%), Gaps = 89/704 (12%)
Query: 54 RNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPD 113
R ++ L+E + + T L+K+ K + SG+ ++ + + L P
Sbjct: 18 RASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFVVGICDLAR--LGPPEPM 75
Query: 114 LGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDY 173
+ KF+ LL H + + +L+K L+G + + ++ F + +
Sbjct: 76 MAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFR-EARRDFWRGAESL 134
Query: 174 ETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKG 233
E T + R A++ E + R ++ + +Y +++N I+ K+
Sbjct: 135 EAALTHNAEVPRRRAQE---------AEEAGAALRTARAGYRGRALDYALQINVIEDKRK 185
Query: 234 VDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLI 293
D+++ +++ AQ FQ G + +L QY ++L A L+ + EK+ + L+
Sbjct: 186 FDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQRHVLL 245
Query: 294 KSSLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGI 353
K ++ + R+G G +G+L K++ K W RR ++++
Sbjct: 246 KQKELGGEEPEPSLREG-----------PGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQ 294
Query: 354 LTISHATSNRQPAK-----LNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWI 408
L + + P L L T ++ P++E + F+++S +++ QA+ E+ W+
Sbjct: 295 LV--YQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWV 352
Query: 409 SVLTNSKEEALTMAFRGE------QSAGENSLEDLTKA----------------IIEDVQ 446
S + +S A + A + Q +G ++ ++ VQ
Sbjct: 353 SAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGGVGHVVAQVQ 412
Query: 447 RLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLL 506
+ GN CCDC P W S NLG+ CI+CSGIHR +GVH S+++SL LD + L
Sbjct: 413 SVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKL 472
Query: 507 AKNVGNNSFNDIMEANLPSPS-PKPTPSSDMTVRKEYITAKYVDHRFSRK---------- 555
+GN N I EA + + + KP PS ++ +I AKYV+ +F K
Sbjct: 473 MCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGG 532
Query: 556 ---------------------TCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLL 594
+ + +E L ++ LL + + M L
Sbjct: 533 RGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRASGHPPSLPTMADAL 592
Query: 595 EPGQEL-----GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSK 649
G ++ G+ ++ SL +FL+QN N+++ + G LH+ ++
Sbjct: 593 AHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGH 652
Query: 650 PECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAK 693
L L+ + + G L IA LL AK
Sbjct: 653 TGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLLRLAK 696
Score = 30.8 bits (68), Expect = 7.6
Identities = 26/70 (37%), Positives = 32/70 (45%), Gaps = 12/70 (17%)
Query: 931 PQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLP 990
P+ PP +PPKP+ + P+P G L KP PP LG L P L P P
Sbjct: 536 PRGQPP--VPPKPS-IRPRP--GSLRSKPE--PPSEDLGSLHPGALLFRASGHP-----P 583
Query: 991 PKPQLGDLLA 1000
P + D LA
Sbjct: 584 SLPTMADALA 593
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 130 bits (328), Expect = 5e-30
Identities = 93/293 (31%), Positives = 144/293 (49%), Gaps = 20/293 (6%)
Query: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
P+A KK S N +T+HF+A ++ AW+ + + + L E
Sbjct: 372 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 428
Query: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486
S ++ L +KA+ ++ +Q + GN C DC + P W S NLG+L CIECSGIHR +G
Sbjct: 429 SKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGT 488
Query: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546
+SR++SLELD + ++GN+ N I E + + KP+ S ++ +I +K
Sbjct: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT-KPSEKSTREEKERWIRSK 547
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
Y + F T + +LL A DL I + A G E + E G+ G TAL
Sbjct: 548 YEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 605
Query: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
HLA R + ++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 606 HLACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 130 bits (327), Expect = 7e-30
Identities = 93/293 (31%), Positives = 144/293 (49%), Gaps = 20/293 (6%)
Query: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
P+A KK S N +T+HF+A ++ AW+ + + + L E
Sbjct: 372 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 428
Query: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486
S ++ L ++A+ ++ +Q + GN C DC + P W S NLG+L CIECSGIHR +G
Sbjct: 429 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGT 488
Query: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546
+SR++SLELD + ++GN+ N I E + + KPT S ++ +I +K
Sbjct: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGRT-KPTEKSTREEKERWIRSK 547
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
Y + F T + +LL A DL I + A G E + E G+ G TAL
Sbjct: 548 YEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 605
Query: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
HLA R + ++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 606 HLACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 129 bits (325), Expect = 1e-29
Identities = 88/283 (31%), Positives = 141/283 (49%), Gaps = 14/283 (4%)
Query: 380 EDKKSFDLIS-HNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLT 438
E+ F ++S +T+HF+A ++ AW+ + + + L E S ++ L +
Sbjct: 498 EENFEFIIVSLTGQTWHFEATTYEERDAWVQAI---ESQILASLQSCESSKNKSRLTSQS 554
Query: 439 KAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELD 497
+A+ ++ ++ + GN C DC + P W S NLG L CIECSGIHR +G H+SR++SL+LD
Sbjct: 555 EAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD 614
Query: 498 KLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTC 557
+ + ++GN N + E + + KP+ S ++ +I AKY F
Sbjct: 615 DWPVELIKVMSSIGNELANSVWEESSQGRT-KPSVDSTREEKERWIRAKYEQKLFLAPLP 673
Query: 558 STSSAKLNELLEAIKSRDLLALIQVYAEGV--ELMEPLLEPGQELGETALHLAVRTADQT 615
T + LL A DL I + A G E+ E G+ G TALHLA R +
Sbjct: 674 CTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETC---GEGDGRTALHLACR---KG 727
Query: 616 SLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 728 NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 770
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 129 bits (325), Expect = 1e-29
Identities = 88/283 (31%), Positives = 141/283 (49%), Gaps = 14/283 (4%)
Query: 380 EDKKSFDLIS-HNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLT 438
E+ F ++S +T+HF+A ++ AW+ + + + L E S ++ L +
Sbjct: 551 EENFEFIIVSLTGQTWHFEATTYEERDAWVQAI---ESQILASLQSCESSKNKSRLTSQS 607
Query: 439 KAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELD 497
+A+ ++ ++ + GN C DC + P W S NLG L CIECSGIHR +G H+SR++SL+LD
Sbjct: 608 EAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD 667
Query: 498 KLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTC 557
+ + ++GN N + E + + KP+ S ++ +I AKY F
Sbjct: 668 DWPVELIKVMSSIGNELANSVWEESSQGRT-KPSVDSTREEKERWIRAKYEQKLFLAPLP 726
Query: 558 STSSAKLNELLEAIKSRDLLALIQVYAEGV--ELMEPLLEPGQELGETALHLAVRTADQT 615
T + LL A DL I + A G E+ E G+ G TALHLA R +
Sbjct: 727 CTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETC---GEGDGRTALHLACR---KG 780
Query: 616 SLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 781 NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 127 bits (320), Expect = 5e-29
Identities = 91/292 (31%), Positives = 142/292 (48%), Gaps = 18/292 (6%)
Query: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
P+A KK S N +T+HF+A ++ AW+ + + + L E
Sbjct: 395 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 451
Query: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486
S ++ L ++A+ ++ +Q + GN C DC + P W S NLG+L CIECSGIHR +G
Sbjct: 452 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGP 511
Query: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546
H+SR++SLELD + ++ N+ N I E + + KP+ S ++ +I +K
Sbjct: 512 HLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQGQT-KPSEKSTREEKERWIRSK 570
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALH 606
Y + F T + +LL A DL I + A G E G+ G TALH
Sbjct: 571 YEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHG-SCEEVNETCGEGDGCTALH 629
Query: 607 LAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
LA R + ++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 630 LACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 127 bits (319), Expect = 6e-29
Identities = 89/282 (31%), Positives = 142/282 (50%), Gaps = 12/282 (4%)
Query: 380 EDKKSFDLIS-HNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLT 438
E+++ F ++S +T HF+A ++ AW+ + + + L E S ++ L +
Sbjct: 270 EEEEKFMIVSVTGQTCHFKATTYEERDAWVQAI---QSQILASLQSCESSKSKSQLTSQS 326
Query: 439 KAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELD 497
+A+ ++ +Q + GN C DC + P W S NLG+L CIECSGIHR +G +SR++SLELD
Sbjct: 327 EAMALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD 386
Query: 498 KLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTC 557
+ ++GN+ N I E + + KP+ S ++ +I +KY F
Sbjct: 387 DWPVELRKVMSSIGNDLANSIWEGSSQGQT-KPSIESTREEKERWIRSKYEHKLFLAPLP 445
Query: 558 STSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETALHLAVRTADQTS 616
T + LL A DL I + A G E + E G+ G TALHLA R + +
Sbjct: 446 CTELSLGQHLLRATADEDLRTAILLLAHGSR--EEVNETCGEGDGCTALHLACR---KGN 500
Query: 617 LHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
+ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 126 bits (316), Expect = 1e-28
Identities = 91/293 (31%), Positives = 143/293 (48%), Gaps = 20/293 (6%)
Query: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
P+A KK S N +T+HF+A ++ AW+ + + + L E
Sbjct: 372 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 428
Query: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486
S ++ L ++A+ ++ +Q + GN C DC + P W S NLG+L CIECSGIH +G
Sbjct: 429 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGT 488
Query: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546
+SR++SLELD + ++GN+ N I E + + KP+ S ++ +I +K
Sbjct: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT-KPSEKSTREEKERWIRSK 547
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
Y + F T + +LL A DL I + A G E + E G+ G TAL
Sbjct: 548 YEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 605
Query: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
HLA R + ++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 606 HLACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 124 bits (310), Expect = 7e-28
Identities = 91/293 (31%), Positives = 142/293 (48%), Gaps = 20/293 (6%)
Query: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
P+A KK S N +T+HF+A ++ AW+ + + + L E
Sbjct: 395 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 451
Query: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486
S ++ L ++A+ ++ +Q + GN C D + P W S NLG+L CIECSGIHR +G
Sbjct: 452 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGT 511
Query: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546
+SR++SLELD + ++GN+ N I E + + KP+ S ++ +I +K
Sbjct: 512 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT-KPSVKSTREEKERWIRSK 570
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
Y + F T + LL A DL I + A G E + E G+ G TAL
Sbjct: 571 YEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 628
Query: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
HLA R + ++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 629 HLACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 122 bits (307), Expect = 1e-27
Identities = 92/296 (31%), Positives = 141/296 (47%), Gaps = 28/296 (9%)
Query: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
P+A KK S N +T+HF+A ++ AW+ + + + L +
Sbjct: 395 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCKS 451
Query: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486
S ++ L ++A+ ++ +Q + GN C DC + P W S NLG+L CIECSGIHR G
Sbjct: 452 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGT 511
Query: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546
+SR++SLELD + ++GN N I E + + KP+ S ++ +I +K
Sbjct: 512 RLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQGQT-KPSIKSTREEKEWWIRSK 570
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
Y + F T + +LL A DL I + A G E + E G+ G TAL
Sbjct: 571 YEEKLFLAPLPCTELSLGQQLLRATTDEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 628
Query: 606 HLAVRTAD---QTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
HLA R + + L VD + ++ A GNT L Y S EC+ +LL+
Sbjct: 629 HLACRKGNVVLEQLLXGVDVMARD--------AHGNTALTYARQASSQECINVLLQ 676
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 122 bits (307), Expect = 1e-27
Identities = 92/296 (31%), Positives = 141/296 (47%), Gaps = 28/296 (9%)
Query: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
P+A KK S N +T+HF+A ++ AW+ + + + L +
Sbjct: 395 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCKS 451
Query: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486
S ++ L ++A+ ++ +Q + GN C DC + P W S NLG+L CIECSGIHR G
Sbjct: 452 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGT 511
Query: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546
+SR++SLELD + ++GN N I E + + KP+ S ++ +I +K
Sbjct: 512 RLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQGQT-KPSIKSTREEKEWWIRSK 570
Query: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
Y + F T + +LL A DL I + A G E + E G+ G TAL
Sbjct: 571 YEEKLFLAPLPCTELSLGQQLLRATTDEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 628
Query: 606 HLAVRTAD---QTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
HLA R + + L VD + ++ A GNT L Y S EC+ +LL+
Sbjct: 629 HLACRKGNVVLEQLLXGVDVMARD--------AHGNTALTYARQASSQECINVLLQ 676
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 119 bits (298), Expect = 2e-26
Identities = 89/284 (31%), Positives = 140/284 (49%), Gaps = 14/284 (4%)
Query: 379 AEDKKSFDLIS-HNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENS-LED 436
AE+ F ++S +T+HF+A ++ W+ S + + + +G +SA + + L +
Sbjct: 603 AEESFEFVVVSLTGQTWHFEASTAEERELWVQ----SVQAQILASLQGCRSAKDKTRLGN 658
Query: 437 LTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLE 495
A+ ++ V+ + GN C DC + P W S NLG L CIECSGIHR +G H+SR++SL+
Sbjct: 659 QNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLD 718
Query: 496 LDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRK 555
LD L + +GN N + E L S KP P + ++ +I AKY F
Sbjct: 719 LDDWPPELLAVMTAMGNALANSVWEGALGGYS-KPGPDACREEKERWIRAKYEQKLFLAP 777
Query: 556 TCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETALHLAVRTADQ 614
S+ +LL A+ DL L+ + A G + E + E G G TALHL+ A+
Sbjct: 778 LPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSK--EEVNETYGDGDGRTALHLSSAMANV 835
Query: 615 TSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
L L+ ++ + A G T L Y EC +L++
Sbjct: 836 VFTQL---LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 118 bits (296), Expect = 3e-26
Identities = 81/288 (28%), Positives = 141/288 (48%), Gaps = 22/288 (7%)
Query: 379 AEDKKSFDLISHN-RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDL 437
AE+ F ++S +T+HF+A ++ AW+ + + +L E S + +
Sbjct: 872 AEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCC---ESSKVKLRTDSQ 928
Query: 438 TKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLEL 496
++A+ I+ ++ GN IC DCG+ PTW S NLG L CIECSGIHR +G H+SR++SL+L
Sbjct: 929 SEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDL 988
Query: 497 DKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKT 556
D L+ +GN++ N + E++ + KP+ S R+ +I AKY F
Sbjct: 989 DDWPRELTLVLTAIGNDTANRVWESDTRGRA-KPSRDSSREERESWIRAKYEQLLFLAPL 1047
Query: 557 CSTSSAKLNELLEAIKSRDLLALIQVYAEG------VELMEPLLEPGQELGETALHLAVR 610
++ +L A++++D+ ++ + A + +P L + LHLA
Sbjct: 1048 STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQL-------RSPLHLA-- 1098
Query: 611 TADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
A+ + + L+ ++ + A G T L Y C +LL+
Sbjct: 1099 -AELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
Score = 38.5 bits (88), Expect = 0.036
Identities = 54/213 (25%), Positives = 77/213 (36%), Gaps = 37/213 (17%)
Query: 782 SPTS---PTTEAP----PLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGH 834
+PTS P +P P P AG G G S P +GS L K PPPP P
Sbjct: 136 APTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHP-----GTGSRRL-KVAPPPPAPKP 189
Query: 835 KRTLSDPPSPLPHGPPNKGAVPWG-NDGGPSSSSKTTNKFEGLSQQSST---------SS 884
+T++ + G + W ++G P ++ G S ++ S+
Sbjct: 190 CKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGST 249
Query: 885 AKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPT 944
A T+ G K++ RK +LD + + P PPP LPP P+
Sbjct: 250 ASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHP---------GPPAGSPPPLTLPPTPS 300
Query: 945 ELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQL 977
PP P P + PP P L
Sbjct: 301 PATAVTAASAQPPGPA-----PPITLEPPAPGL 328
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 117 bits (293), Expect = 6e-26
Identities = 79/288 (27%), Positives = 142/288 (49%), Gaps = 24/288 (8%)
Query: 381 DKKSFDLI---SHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDL 437
++++F+ + S +T+HF+A ++ AW+ + + +L E S + +
Sbjct: 516 EEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCC---ESSKVKLRTDSQ 572
Query: 438 TKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLEL 496
++A+ I+ ++ GN IC DCG+ PTW S NLG L CIECSGIHR +G H+SR++SL+L
Sbjct: 573 SEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDL 632
Query: 497 DKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKT 556
D L+ +GN++ N + E++ + KP+ S R+ +I AKY F
Sbjct: 633 DDWPRELTLVLTAIGNDTANRVWESDTRGRA-KPSRDSSREERESWIRAKYEQLLFLAPL 691
Query: 557 CSTSSAKLNELLEAIKSRDLLALIQVYAEG------VELMEPLLEPGQELGETALHLAVR 610
++ +L A++++D+ ++ + A + +P L + LHLA
Sbjct: 692 STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQL-------RSPLHLA-- 742
Query: 611 TADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
A+ + + L+ ++ + A G T L Y C +LL+
Sbjct: 743 -AELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 94.7 bits (234), Expect = 4e-19
Identities = 54/176 (30%), Positives = 90/176 (51%), Gaps = 20/176 (11%)
Query: 381 DKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKA 440
D++SFDL + R + F A+ E + W+ + + EAL+ T
Sbjct: 249 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS-----------------TSE 291
Query: 441 IIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLG 500
+ E + N C DCG+ +P W S NL ++ C C+G HR +G +S+++SL++D+
Sbjct: 292 VAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKV 351
Query: 501 TSELL--LAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSR 554
+E L L +GN + N AN+P PS PSS + R+ ++ AKY + ++ R
Sbjct: 352 WTETLIELFLQLGNGAGNRFWAANVP-PSEALQPSSSPSTRRCHLEAKYREGKYRR 406
Score = 32.7 bits (73), Expect = 2.0
Identities = 44/215 (20%), Positives = 82/215 (38%), Gaps = 26/215 (12%)
Query: 327 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFD 386
K G+L K ++Q+R + L + + + + C A + F+
Sbjct: 85 KAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFE 144
Query: 387 LISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQ 446
+I++NRT+ F+AE + + W+ L + E + + L+ A + V
Sbjct: 145 VITNNRTFAFRAESDVERKEWMQALQQAMAE-------------QRARARLSSAYLLGV- 190
Query: 447 RLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLL 506
PG++ GS E L + +G + ++LE LG +
Sbjct: 191 --PGSEQPDRAGSLELRGFKNKLYVAV----------VGDKVQLYKNLEEYHLGIGITFI 238
Query: 507 AKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKE 541
+VGN D +L +P + S+D + KE
Sbjct: 239 DMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKE 273
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 94.7 bits (234), Expect = 4e-19
Identities = 54/176 (30%), Positives = 90/176 (51%), Gaps = 20/176 (11%)
Query: 381 DKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKA 440
D++SFDL + R + F A+ E + W+ + + EAL+ T
Sbjct: 494 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS-----------------TSE 536
Query: 441 IIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLG 500
+ E + N C DCG+ +P W S NL ++ C C+G HR +G +S+++SL++D+
Sbjct: 537 VAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKV 596
Query: 501 TSELL--LAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSR 554
+E L L +GN + N AN+P PS PSS + R+ ++ AKY + ++ R
Sbjct: 597 WTETLIELFLQLGNGAGNRFWAANVP-PSEALQPSSSPSTRRCHLEAKYREGKYRR 651
Score = 50.8 bits (120), Expect = 7e-06
Identities = 54/199 (27%), Positives = 67/199 (33%), Gaps = 61/199 (30%)
Query: 782 SPTSPTTEAPPLPPRNAGKG-PTGPP-----STLPLSTQTSSGSSTLSKKRPPPPPPGHK 835
SP P T PLP +G P PP S LP + T+ ++ PP P H
Sbjct: 91 SPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHL 150
Query: 836 RTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLP 895
LS PP P GP PR+L
Sbjct: 151 AELSVPPVPPRTGP-----------------------------------------PRLLV 169
Query: 896 KLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPP--------PGDLPPKPTELA 947
LP K + L + PP+ Q L+ LPQ PP P ++PPKP L
Sbjct: 170 SLP-----TKEEESLLPSLSSPPQP-QSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLF 223
Query: 948 PKPQIGDLPPKPGELPPKP 966
P+ D P E P P
Sbjct: 224 PEFDDSDYDEVPEEGPGAP 242
Score = 43.1 bits (100), Expect = 0.001
Identities = 55/234 (23%), Positives = 87/234 (37%), Gaps = 19/234 (8%)
Query: 863 PSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQ 922
P+ + + T + + + S A P LP + L + ++ +PP F
Sbjct: 71 PAPAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFT 130
Query: 923 KSSQLAELPQKPPPGDLPPKP--TELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDL 980
S A P PP LP K EL+ P +PP+ G PP+ L LP K + S L
Sbjct: 131 TPSTAAPDPVLPP---LPAKRHLAELSVPP----VPPRTG--PPR-LLVSLPTKEEESLL 180
Query: 981 PPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRD---AIQ 1037
P PP+PQ + L+ G P + P + P+ L P D +
Sbjct: 181 PSLSS----PPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPE 236
Query: 1038 KQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEG 1091
+ + +T P +PR + + D Q D +++ EG
Sbjct: 237 EGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEG 290
Score = 32.7 bits (73), Expect = 2.0
Identities = 44/215 (20%), Positives = 82/215 (38%), Gaps = 26/215 (12%)
Query: 327 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFD 386
K G+L K ++Q+R + L + + + + C A + F+
Sbjct: 330 KAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFE 389
Query: 387 LISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQ 446
+I++NRT+ F+AE + + W+ L + E + + L+ A + V
Sbjct: 390 VITNNRTFAFRAESDVERKEWMQALQQAMAE-------------QRARARLSSAYLLGV- 435
Query: 447 RLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLL 506
PG++ GS E L + +G + ++LE LG +
Sbjct: 436 --PGSEQPDRAGSLELRGFKNKLYVAV----------VGDKVQLYKNLEEYHLGIGITFI 483
Query: 507 AKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKE 541
+VGN D +L +P + S+D + KE
Sbjct: 484 DMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKE 518
>gi|23943872 small ArfGAP2 [Homo sapiens]
Length = 429
Score = 88.6 bits (218), Expect = 3e-17
Identities = 42/116 (36%), Positives = 66/116 (56%), Gaps = 2/116 (1%)
Query: 436 DLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLE 495
D +A++ ++ N C DC S P W S N+G+ CI C+GIHR +GVHISR++S+
Sbjct: 10 DRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVN 69
Query: 496 LDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKP--TPSSDMTVRKEYITAKYVD 549
LD+ ++ + +GN N + EA LP +P P+ + +R +Y KY+D
Sbjct: 70 LDQWTQEQIQCMQEMGNGKANRLYEAYLPETFRRPQIDPAVEGFIRDKYEKKKYMD 125
>gi|113204622 stromal membrane-associated GTPase-activating protein
1 isoform A [Homo sapiens]
Length = 467
Score = 87.8 bits (216), Expect = 5e-17
Identities = 46/140 (32%), Positives = 75/140 (53%), Gaps = 3/140 (2%)
Query: 434 LEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQS 493
L + + I+ + R N C DC + P W S N+G+ CI C+GIHR +GVHISR++S
Sbjct: 13 LNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKS 72
Query: 494 LELDKLGTSELLLAKNVGNNSFNDIMEANLPS--PSPKPTPSSDMTVRKEYITAKYVD-H 550
+ LD+ ++ +++GN + EANLP P+ + + +R +Y KY D +
Sbjct: 73 VNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYDKN 132
Query: 551 RFSRKTCSTSSAKLNELLEA 570
+ S+S A L L+ +
Sbjct: 133 AIAITNISSSDAPLQPLVSS 152
>gi|21264558 stromal membrane-associated GTPase-activating protein 1
isoform B [Homo sapiens]
Length = 440
Score = 85.9 bits (211), Expect = 2e-16
Identities = 41/118 (34%), Positives = 65/118 (55%), Gaps = 2/118 (1%)
Query: 434 LEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQS 493
L + + I+ + R N C DC + P W S N+G+ CI C+GIHR +GVHISR++S
Sbjct: 13 LNEQHQLILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKS 72
Query: 494 LELDKLGTSELLLAKNVGNNSFNDIMEANLPS--PSPKPTPSSDMTVRKEYITAKYVD 549
+ LD+ ++ +++GN + EANLP P+ + + +R +Y KY D
Sbjct: 73 VNLDQWTAEQIQCMQDMGNTKARLLYEANLPENFRRPQTDQAVEFFIRDKYEKKKYYD 130
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
2 [Homo sapiens]
Length = 1704
Score = 85.5 bits (210), Expect = 3e-16
Identities = 63/214 (29%), Positives = 106/214 (49%), Gaps = 24/214 (11%)
Query: 382 KKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAI 441
K+SF++I+ R++ F AE E++ WI + S E L+ +
Sbjct: 645 KQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLS-----------------DYEV 687
Query: 442 IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELD-KLG 500
E + N C DC + +P W S NL ++ C +C+G HR +G S+++SL++D +
Sbjct: 688 AEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIW 747
Query: 501 TSELL-LAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKT--C 557
++EL+ L +GN ND NL + S + RK +IT KY + +F RKT
Sbjct: 748 SNELIELFIVIGNKRANDFWAGNL-QKDEELHMDSPVEKRKNFITQKYKEGKF-RKTLLA 805
Query: 558 STSSAKLNE-LLEAIKSRDLLALIQVYAEGVELM 590
S + +LN+ L A+ D+L + + G ++M
Sbjct: 806 SLTKEELNKALCAAVVKPDVLETMALLFSGADVM 839
Score = 37.4 bits (85), Expect = 0.081
Identities = 26/97 (26%), Positives = 52/97 (53%), Gaps = 5/97 (5%)
Query: 327 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQV--KPNAEDKKS 384
K G+L K S ++++Q+R VK L+IS+ + ++ ++ +
Sbjct: 485 KSGWLDKLSPQGKRMFQKRW--VKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK 542
Query: 385 FDLISHNRTYHFQAEDEQDYVAWISVLTNS-KEEALT 420
F++++ RT+ F+ E E++ WIS+L N+ K ++LT
Sbjct: 543 FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLT 579
>gi|6806913 centaurin, alpha 1 [Homo sapiens]
Length = 374
Score = 85.1 bits (209), Expect = 3e-16
Identities = 42/114 (36%), Positives = 69/114 (60%), Gaps = 2/114 (1%)
Query: 439 KAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDK 498
+A++E +QR PGN C DCG+ +P W S LG+ C+ CSGIHR + +S+++S+ LD
Sbjct: 7 RAVLELLQR-PGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNI-PQVSKVKSVRLDA 64
Query: 499 LGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRF 552
+++ + GN++ E+ +PS +PTPS +R+++I AKY F
Sbjct: 65 WEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEF 118
Score = 35.0 bits (79), Expect = 0.40
Identities = 30/133 (22%), Positives = 54/133 (40%), Gaps = 17/133 (12%)
Query: 301 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT 360
Q+ S + G+ + + N ++ S K ++L + +G K + R ++ I H
Sbjct: 124 QEPYSAGYREGFLWKRGRDNGQFLSRK--FVLTEREGALKYFNRNDAKEPKAVMKIEHLN 181
Query: 361 SNRQPAKL----NLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKE 416
+ QPAK+ L +K N+ R ED ++ V W + L ++
Sbjct: 182 ATFQPAKIGHPHGLQVTYLKDNS-----------TRNIFIYHEDGKEIVDWFNALRAARF 230
Query: 417 EALTMAFRGEQSA 429
L +AF G A
Sbjct: 231 HYLQVAFPGASDA 243
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 82.8 bits (203), Expect = 2e-15
Identities = 81/311 (26%), Positives = 116/311 (37%), Gaps = 32/311 (10%)
Query: 781 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD 840
+SP SP E P P + PP LP S + + + P PP + LS
Sbjct: 446 ESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSP 505
Query: 841 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALG--PRVLPKLP 898
PP P P + + + PS + +T + S ++ L P LP P
Sbjct: 506 PPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSP 565
Query: 899 QKVALRKTDHLSLDKATIPPEIFQKS---------SQLAELPQKPPPGDL----PPKPTE 945
A R + + PPE S E P PPP + PP+ +
Sbjct: 566 PPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASR 625
Query: 946 LAPKPQIGDLPPKPGELP--PKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQ 1003
L+P P+ + P P E P P P++ L P P +S L P P+ L P P+ +
Sbjct: 626 LSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPE 685
Query: 1004 TGDVSP--------------KAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTP 1049
+SP A P E +L S PL+ SP + + Q + L+P
Sbjct: 686 ASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSP 745
Query: 1050 TLPETPVPLPR 1060
PE P PR
Sbjct: 746 R-PEEPHLSPR 755
Score = 74.3 bits (181), Expect = 6e-13
Identities = 81/335 (24%), Positives = 127/335 (37%), Gaps = 38/335 (11%)
Query: 725 PSPIKKERSPRPQSF-----CHSSSISP---QDKLALPGFSTPRDKQRLSYGAFTNQIFV 776
P P + SP P++ S +SP + L+ P S+P S + +
Sbjct: 469 PPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPP 528
Query: 777 STSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKR 836
S + ++P SP EA PL P + PP LP S + + + P PP +
Sbjct: 529 SPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEES 588
Query: 837 TLSDPP-----------SPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSA 885
+S PP SPL P P P +S+ + E +
Sbjct: 589 PMSPPPEASRLFPPFEESPLSPPPEESPLSP------PPEASRLSPPPEDSPMSPPPEES 642
Query: 886 KTALGPRVLPKLPQKVALR-----KTDHLSL----DKATIPPEIFQKSSQLAELPQKPPP 936
+ P V P V R + LS + PPE + S + P PPP
Sbjct: 643 PMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPP 702
Query: 937 GDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLG 996
D P P P+ + LP + L P P+ L P+ + L P+P+ L P+P+
Sbjct: 703 EDSPASPP---PEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEP 759
Query: 997 DLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQ 1031
L +++ +SP+ ++P + P LSP +
Sbjct: 760 HLSPQAEEPHLSPQPEEPCLCAVPEEP-HLSPQAE 793
Score = 72.4 bits (176), Expect = 2e-12
Identities = 91/336 (27%), Positives = 129/336 (38%), Gaps = 49/336 (14%)
Query: 725 PSPIKKERSPRPQSFCHS----SSISPQDK------LALPGFSTPRDKQRLSYGAFTNQI 774
P P + SP P+S S S +SP ++ L P S P + LS F
Sbjct: 496 PPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETP-LSPPPEASPLS-PPFEESP 553
Query: 775 FVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSG-------SSTLSKKRP 827
+ PTSP EA L P + PP P+S + S LS P
Sbjct: 554 LSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLS---P 610
Query: 828 PP------PPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSS 881
PP PPP R LS PP P PP + + P S ++ L S
Sbjct: 611 PPEESPLSPPPEASR-LSPPPEDSPMSPPPEES--------PMSPPPEVSRLSPLPVVSR 661
Query: 882 TSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGD--- 938
S P P P + + + PPE S + P PPP D
Sbjct: 662 LSPP-----PEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLM 716
Query: 939 -LPPKPTELAPKPQIGDLPPKPG--ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQL 995
LP + + L P P+ L P+ L P+P+ L P+P+ L P+ + L P+P+
Sbjct: 717 SLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEE 776
Query: 996 GDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQ 1031
L A + +SP+A+ P ++ + L LSP +
Sbjct: 777 PCLCAVPEEPHLSPQAEGP-HLSPQPEELHLSPQTE 811
Score = 67.0 bits (162), Expect = 1e-10
Identities = 78/320 (24%), Positives = 123/320 (38%), Gaps = 31/320 (9%)
Query: 719 DDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVST 778
++L P P SP P+ S +SP + + S P + RL + F
Sbjct: 559 EELPTSPPPEASRLSPPPEE----SPMSPPPEES--PMSPPPEASRL-FPPFEESPLSPP 611
Query: 779 STDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTS----SGSSTLSKKRPPP----- 829
+SP SP EA L P + PP P+S S +S+ PPP
Sbjct: 612 PEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPL 671
Query: 830 -PPPGHKRT--------LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQS 880
PPP T LS PP P PP + + P S S + L
Sbjct: 672 SPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDS-PASPPPEDSLMSLPLEESPLLPLPE 730
Query: 881 STSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQ--LAELPQKPPPGD 938
+ GP + P+ + + + L P + + + L +P++P
Sbjct: 731 EPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSP 790
Query: 939 LPPKPTELAPKPQIGDLPPKPGE--LPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLG 996
P L+P+P+ L P+ E L P P+ L P+P+ S L P+ + L P+P+
Sbjct: 791 QAEGP-HLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEES 849
Query: 997 DLLAKSQTGDVSPKAQQPSE 1016
L + + +SP+ ++P E
Sbjct: 850 HLSPELEKPPLSPRPEKPPE 869
Score = 63.2 bits (152), Expect = 1e-09
Identities = 75/283 (26%), Positives = 106/283 (37%), Gaps = 39/283 (13%)
Query: 785 SPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSP 844
+P E PL P PP PLS ++ P PPP R LS PP
Sbjct: 432 APLNEEMPLLP---------PPEESPLSPPP--------EESPTSPPPEASR-LSPPPEE 473
Query: 845 LPHGP-PNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSS-AKTALGPRVLPKLPQKVA 902
LP P P + + P S + + S S ++ L P + P A
Sbjct: 474 LPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPP--EESPPSPA 531
Query: 903 LRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDL----PPKPTELAPKPQIGDLPPK 958
L + PPE S E P PPP +L PP+ + L+P P+ + P
Sbjct: 532 LE-------TPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPP 584
Query: 959 PGELP--PKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSE 1016
P E P P P+ L P + S L P P+ L P P+ L + +SP P E
Sbjct: 585 PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSP----PPE 640
Query: 1017 VTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLP 1059
+ S P ++S + + + L+P E+P P
Sbjct: 641 ESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPP 683
Score = 60.5 bits (145), Expect = 9e-09
Identities = 66/285 (23%), Positives = 112/285 (39%), Gaps = 23/285 (8%)
Query: 795 PRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGA 854
P G PT P L ++ Q ++ +P P P + + P +
Sbjct: 374 PPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAP 433
Query: 855 VPWGNDGGPSSSSKTTNKFEGLSQQSSTS----SAKTALGPRVLPKLPQKVALRKTDHLS 910
+ N+ P + ++S TS +++ + P LP P AL + L
Sbjct: 434 L---NEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLE 490
Query: 911 LDKATIPPEIF-----QKSSQLAELPQKP--PPGDLPPKP---TELAPKPQIGDLPPKPG 960
+ PPE +SS + L + P PP + PP P T L+P P+ L P
Sbjct: 491 ESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFE 550
Query: 961 ELPPKPQLGDLP--PKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVT 1018
E P P +LP P P+ S L P P+ + P P+ + + + P P E +
Sbjct: 551 ESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFP----PFEES 606
Query: 1019 LKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKIN 1063
S P + SP +A + + + ++P E+P+ P +++
Sbjct: 607 PLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVS 651
Score = 41.2 bits (95), Expect = 0.006
Identities = 73/316 (23%), Positives = 115/316 (36%), Gaps = 64/316 (20%)
Query: 783 PTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPP 842
PT+P T PP P PTG P+ P+ +S RP PG T PP
Sbjct: 2190 PTAPPTY-PPYP------SPTGAPAQPPMLGASS---------RPGAGQPGEFHTT--PP 2231
Query: 843 SPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVA 902
H P P+ PS + + G+ +++ L P + + +
Sbjct: 2232 GTPRHQPSTPD--PFLKPRCPSLDNLAVPESPGVG---GGKASEPLLSPPPFGESRKALE 2286
Query: 903 LRKTDHLSLDKATIPPEIF-----QKSSQLAELPQKPPP---GDLPPKPTELAPKPQIGD 954
++K + + + PP + + L L K P L P+ +++ +PQ
Sbjct: 2287 VKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQV--EPQSPG 2344
Query: 955 LPPKPGELPPKPQLGDLPP----------------KPQLSDLPPKPQMKD---LPPKPQL 995
L +P E PP L PP +P L+ P P + LPP+
Sbjct: 2345 LGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLP 2404
Query: 996 GDLLAKSQTGDVSPKAQQPSEVTLKSHPLD--------LSPNVQSRDAIQKQASE-DSND 1046
D ++ SP++Q S+ L PL ++P QS D + S S D
Sbjct: 2405 SDPFSRV---PASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRD 2461
Query: 1047 LTPTLPETPVPLPRKI 1062
L + P P P ++
Sbjct: 2462 PFAPLHKPPRPQPPEV 2477
Score = 40.4 bits (93), Expect = 0.010
Identities = 82/326 (25%), Positives = 114/326 (34%), Gaps = 35/326 (10%)
Query: 725 PSPIKKERSPRPQS-----FCHSSSISPQDKLAL-------PGFSTPRDKQRLSYGAFTN 772
P P + SPRP+ +SPQ + P S + LS
Sbjct: 745 PRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLS--PQPE 802
Query: 773 QIFVSTSTDSP-TSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPP 831
++ +S T+ P SP E P L P+ + P S P + S + PP
Sbjct: 803 ELHLSPQTEEPHLSPVPEEPCLSPQPE-ESHLSPQSEEPCLSPRPEESHLSPELEKPPLS 861
Query: 832 PGHKRTLSDP-----PSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTS-SA 885
P ++ +P P LP PP G P+ S L ++ S S
Sbjct: 862 PRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSG 921
Query: 886 KTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQK-PPPGDLPPKPT 944
+ +L P+++P P L + A PP + S L EL GD P+
Sbjct: 922 EPSLSPQLMPPDPLPPPLSP-----IITAAAPPAL----SPLGELEYPFGAKGDSDPESP 972
Query: 945 ELAPKPQIGDLPPKPGE-LPPKP-QLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKS 1002
AP + PP P+P LPP P P P + + P PQ LL S
Sbjct: 973 LAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILME-PLPPQCSPLLQHS 1031
Query: 1003 QTGDVSPKAQQPSEVTLKSHPLDLSP 1028
SP +Q S P LSP
Sbjct: 1032 LVPQNSPPSQCSPPALPLSVPSPLSP 1057
Score = 36.6 bits (83), Expect = 0.14
Identities = 44/162 (27%), Positives = 60/162 (37%), Gaps = 17/162 (10%)
Query: 786 PTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPP--PGHKRTLSDPPS 843
P + PL AG P GPP LP S L P PPP P + S PS
Sbjct: 4267 PGPQTGPLQELGAGPRPQGPP-RLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPS 4325
Query: 844 PLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKT----ALGPRVLP---- 895
P P + +P + G P T G ++ A T LGP P
Sbjct: 4326 PSSQ-LPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLA 4384
Query: 896 --KLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPP 935
+ P++ +L HL + PE Q S + + P++ P
Sbjct: 4385 ETQKPEQSSL-VPGHLDQVNGQVVPEASQLS--IKQEPREEP 4423
Score = 36.2 bits (82), Expect = 0.18
Identities = 55/227 (24%), Positives = 75/227 (33%), Gaps = 38/227 (16%)
Query: 792 PLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTL------SDPPSPL 845
P P + P P + T + RP PPPP L SDP S +
Sbjct: 2352 PPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRV 2411
Query: 846 PHGPPNKGAVPWGNDGGPSSS-----SKTTNKFEG---LSQQSSTSSAKTALGPRVLPKL 897
P P ++ + P S+ S T +F+ S+ S ++ P P
Sbjct: 2412 PASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPR 2471
Query: 898 PQ--KVALRKTD--HLSLDKATIPPEIFQKSSQLAELPQKPPPGDLP------------- 940
PQ +VA + H SL P + + EL K P G P
Sbjct: 2472 PQPPEVAFKAGSLAHTSLGAGGFPAAL--PAGPAGELHAKVPSGQPPNFVRSPGTGAFVG 2529
Query: 941 -PKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQM 986
P P +G+ P PP PQ G PP S P P +
Sbjct: 2530 TPSPMRFTFPQAVGE----PSLKPPVPQPGLPPPHGINSHFGPGPTL 2572
Score = 35.4 bits (80), Expect = 0.31
Identities = 49/180 (27%), Positives = 64/180 (35%), Gaps = 38/180 (21%)
Query: 846 PHGPPNKGAVPW-GNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALR 904
P P G P G GP K EG S + K VLP K L
Sbjct: 4820 PESPARAGTEPKKGEAEGPGGKEKG---LEGKSPDTGPDWLKQF--DAVLPGYTLKSQL- 4873
Query: 905 KTDHLSLDK----ATIPPEIFQKSSQLAELPQK----PPPGDLPPKPTELAPKPQIGDLP 956
D LSL K A PP + ++ L + PPP + P P+ LAP P
Sbjct: 4874 --DILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPA----- 4926
Query: 957 PKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSE 1016
PP L +LP +P + PP P L + ++ P+A+ P E
Sbjct: 4927 --------------SPPTEPLVELPTEPLAE--PPVPSPLPLASSPESARPKPRARPPEE 4970
Score = 35.0 bits (79), Expect = 0.40
Identities = 48/202 (23%), Positives = 69/202 (34%), Gaps = 17/202 (8%)
Query: 841 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK 900
PP P G P A P G P++ + + +G + + S + KLP +
Sbjct: 2107 PPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQ 2166
Query: 901 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG 960
V + A P P PP P PT +P + +PG
Sbjct: 2167 VPAQVPSQDPFGLAPAYP-------LEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPG 2219
Query: 961 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK 1020
P P P+ P P +K P P L +L G KA +P L
Sbjct: 2220 AGQPGEFHTTPPGTPRHQPSTPDPFLK--PRCPSLDNLAVPESPGVGGGKASEP----LL 2273
Query: 1021 SHPLDLSPNVQSRDAIQKQASE 1042
S P P +SR A++ + E
Sbjct: 2274 SPP----PFGESRKALEVKKEE 2291
Score = 34.7 bits (78), Expect = 0.53
Identities = 62/240 (25%), Positives = 87/240 (36%), Gaps = 37/240 (15%)
Query: 811 LSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTT 870
L Q S ++ PP PG T + P L P G P G GP
Sbjct: 4225 LLMQRQLQQSQAVRQTPPYQEPG---TQTSPLQGLLGCQPQLGGFP-GPQTGPLQELGAG 4280
Query: 871 NKFEG---LSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQL 927
+ +G L S LGP V P P S + P ++ SSQL
Sbjct: 4281 PRPQGPPRLPAPPGALSTGPVLGP-VHPTPPPS---------SPQEPKRPSQLPSPSSQL 4330
Query: 928 AELPQKPP--PGDLPPKPTELAPKPQIGDLPPKPGEL-PPKPQLGDLPPKPQLSDLPPKP 984
Q PP PG PKPQ L P PG + P QL D L P
Sbjct: 4331 PTEAQLPPTHPG---------TPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPD 4381
Query: 985 QMKDLPPKPQLGDLL---AKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQAS 1041
+ + KP+ L+ G V P+A S++++K P + P +++++A+
Sbjct: 4382 NLAE-TQKPEQSSLVPGHLDQVNGQVVPEA---SQLSIKQEPRE-EPCALGAQSVKREAN 4436
Score = 31.6 bits (70), Expect = 4.4
Identities = 63/275 (22%), Positives = 96/275 (34%), Gaps = 60/275 (21%)
Query: 872 KFEGLSQQSSTSSAKTALGPRVLPKLPQKVA---------LRKTDHLSLDKATIPPEIFQ 922
K +G ++A+ L P+ PK QK + LRK D + +A + Q
Sbjct: 4501 KLQGTPSNKEDAAARKPLTPK--PKRVQKASDRLVSSRKKLRKEDGVRASEALLK----Q 4554
Query: 923 KSSQLAELPQKPPP-------------GDLPPKPTELAPKPQIGDLPPKP---GELPPKP 966
+L+ LP P G ++L G LP P +L K
Sbjct: 4555 LKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKN 4614
Query: 967 QLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDL 1026
L + P P S LPP P PP Q + V+P + L HP D
Sbjct: 4615 NLSNPPTPP--SSLPPTP-----PPSVQ------QKMVNGVTPSEE------LGEHPKDA 4655
Query: 1027 SPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDEL 1086
+ S A++ + S DL LP P N+ V+ D +D+ D +
Sbjct: 4656 ASARDSERALRDTSEVKSLDLLAALPTPP----------HNQTEDVRMESDEDSDSPDSI 4705
Query: 1087 TFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPV 1121
I+ E + +G + E + + PV
Sbjct: 4706 VPASSPESILGEEAPRFPHLGSGRWEQEDRALSPV 4740
Score = 30.4 bits (67), Expect = 9.9
Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 15/102 (14%)
Query: 931 PQKPPPGDLPPKPTELAPKP----QIGDLPPKPGELPPKPQLGD-LPPKPQLS--DLPPK 983
PQ+P + P LAP+ + LPP+ PP P+L + L P P LP
Sbjct: 2901 PQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKGPTLPTG 2960
Query: 984 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLD 1025
++ + PP + ++ G +P A + ++ + LD
Sbjct: 2961 LELVNRPP--------SSTELGRPNPLALEAGKLPCEDPELD 2994
Score = 30.4 bits (67), Expect = 9.9
Identities = 41/159 (25%), Positives = 53/159 (33%), Gaps = 15/159 (9%)
Query: 831 PPGHKRTLSDPPSPLPHGP--PNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTA 888
P R ++P GP KG D GP + G + +S
Sbjct: 4820 PESPARAGTEPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLL 4879
Query: 889 LGPRVLPKLP-QKVALRKTDHLSLDKATIPP--EIFQKSSQLAELPQKPPPGDLPPKPTE 945
P+ P Q +L + + + PP E S LA P PP L PTE
Sbjct: 4880 KQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTE 4939
Query: 946 -LAPKPQIGDLP---------PKPGELPPKPQLGDLPPK 974
LA P LP PKP PP+ PP+
Sbjct: 4940 PLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPPR 4978
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
3 [Homo sapiens]
Length = 1544
Score = 80.9 bits (198), Expect = 6e-15
Identities = 59/182 (32%), Positives = 91/182 (50%), Gaps = 22/182 (12%)
Query: 368 LNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
+ L C V+ +SFDL++ +R + F AE +W + L +EA+T
Sbjct: 437 IELQGCSVRETKS--RSFDLLTPHRCFSFTAESGGARQSWAAAL----QEAVT------- 483
Query: 428 SAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVH 487
+L D A E + N C DCGSS P W + NLG++ C +C+G HR +G
Sbjct: 484 ----ETLSDYEVA--EKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSG 537
Query: 488 ISRIQSLELD-KLGTSELL-LAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITA 545
IS++QSL+LD + ++E++ L +GN+ N LP P P + R E+I+
Sbjct: 538 ISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLP-PGEGLHPDATPGPRGEFISR 596
Query: 546 KY 547
KY
Sbjct: 597 KY 598
Score = 30.4 bits (67), Expect = 9.9
Identities = 27/104 (25%), Positives = 38/104 (36%), Gaps = 14/104 (13%)
Query: 777 STSTDSPTSPTTEAPPLP---PRNAGKGPTGPPSTLPLSTQTSSGSSTLSKK-----RPP 828
S SP+ PP P PR G +GP +T + G +S+ RPP
Sbjct: 77 SAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRPGLSPALGGPGVSRSPEPSPRPP 136
Query: 829 PPPPGHK------RTLSDPPSPLPHGPPNKGAVPWGNDGGPSSS 866
P P T+ P+ + G ++G D P SS
Sbjct: 137 PLPTSSSEQSSALNTVEMMPNSIYFGLDSRGRAQAAQDKAPDSS 180
Score = 30.4 bits (67), Expect = 9.9
Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 14/91 (15%)
Query: 744 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT 803
S+ Q++L P + P ++ GAF ++ TST T+ P P + K
Sbjct: 1391 SVEEQEELEEPVYEEPVYEE---VGAFP-ELIQDTSTSFSTTREWTVKPENPLTSQKS-- 1444
Query: 804 GPPSTLPLSTQTSSGSSTLSK-KRPPPPPPG 833
L S SSTL + +RPP PPPG
Sbjct: 1445 -------LDQPFLSKSSTLGQEERPPEPPPG 1468
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,027,590
Number of Sequences: 37866
Number of extensions: 2949173
Number of successful extensions: 31981
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 531
Number of HSP's successfully gapped in prelim test: 1504
Number of HSP's that attempted gapping in prelim test: 15510
Number of HSP's gapped (non-prelim): 9829
length of query: 1129
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1016
effective length of database: 13,968,660
effective search space: 14192158560
effective search space used: 14192158560
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.