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Search of human proteins with 46049100
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46049100 NACHT, leucine rich repeat and PYD containing 7
isoform 1 [Homo sapiens]
(1009 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 2048 0.0
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 2033 0.0
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 1828 0.0
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 1194 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 561 e-160
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 466 e-131
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 461 e-129
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 446 e-125
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 446 e-125
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 443 e-124
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 442 e-124
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 441 e-123
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 405 e-113
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 405 e-113
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 397 e-110
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 371 e-102
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 343 4e-94
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 330 4e-90
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 330 4e-90
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 330 4e-90
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 327 5e-89
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 327 5e-89
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 255 2e-67
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 219 1e-56
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 144 3e-34
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 144 3e-34
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 144 3e-34
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 144 3e-34
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 144 3e-34
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 144 3e-34
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
[Homo sapiens]
Length = 1009
Score = 2048 bits (5306), Expect = 0.0
Identities = 1009/1009 (100%), Positives = 1009/1009 (100%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLS 660
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLS
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLS 660
Query: 661 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 720
DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM
Sbjct: 661 DSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTM 720
Query: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML
Sbjct: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
Query: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE
Sbjct: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
Query: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALEN 900
GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALEN
Sbjct: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALEN 900
Query: 901 PNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTG 960
PNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTG
Sbjct: 901 PNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTG 960
Query: 961 SLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAPPCCDFFC 1009
SLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAPPCCDFFC
Sbjct: 961 SLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDCNASGATAPPCCDFFC 1009
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 2033 bits (5267), Expect = 0.0
Identities = 1009/1037 (97%), Positives = 1009/1037 (97%), Gaps = 28/1037 (2%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE----------------- 643
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
Query: 644 -----------SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 692
SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY
Sbjct: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
Query: 693 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 752
RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE
Sbjct: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
Query: 753 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 812
FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA
Sbjct: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
Query: 813 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 872
VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ
Sbjct: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
Query: 873 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 932
EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK
Sbjct: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 960
Query: 933 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI
Sbjct: 961 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
Query: 993 DCNASGATAPPCCDFFC 1009
DCNASGATAPPCCDFFC
Sbjct: 1021 DCNASGATAPPCCDFFC 1037
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 1828 bits (4735), Expect = 0.0
Identities = 910/938 (97%), Positives = 910/938 (97%), Gaps = 28/938 (2%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE----------------- 643
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
Query: 644 -----------SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 692
SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY
Sbjct: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
Query: 693 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 752
RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE
Sbjct: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
Query: 753 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 812
FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA
Sbjct: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
Query: 813 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 872
VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ
Sbjct: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
Query: 873 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRL 910
EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRL
Sbjct: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRL 938
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 1194 bits (3088), Expect = 0.0
Identities = 647/1051 (61%), Positives = 755/1051 (71%), Gaps = 66/1051 (6%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
++S Q+ + LQ LLEQL++DEL FK L+ F L LQK P EV++ADGK+L EIL
Sbjct: 2 VSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTT 61
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQ------------VQEIDNPELGDA 108
W+ A++ + E+M+ +L + AK E+ E + + P L D
Sbjct: 62 HCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPL-DV 120
Query: 109 EEDSELAKP---------------------GEKEGWRNSME-----KQSLVWKNTFWQGD 142
+E E K G+K N K +WK+ W GD
Sbjct: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKS--WPGD 178
Query: 143 IDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSP 202
+ R + IPF NPR YTVVL+GPAG+GKTTLA+K MLDW + NL
Sbjct: 179 SKEVQV-MAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH 237
Query: 203 TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPP 262
+YAFYLSC+ELSR+GPCSFAEL+ +DWPELQDDIP ILAQA++ILFV+DG DEL P
Sbjct: 238 KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAP 297
Query: 263 GALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE 322
GALI+DICGDWEKKKPVPVLLGSLL R MLP+AALLVTTRPRALRDL++LA++PIY+RVE
Sbjct: 298 GALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVE 357
Query: 323 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 382
GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED
Sbjct: 358 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 417
Query: 383 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE 442
PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQ SV HREDLERLGVQE
Sbjct: 418 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQE 477
Query: 443 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQK 502
SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY LEKEE EDRDGH WDIGDVQK
Sbjct: 478 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQK 537
Query: 503 LLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKP 562
LLSG ERL+NPDLIQ G++ FGLANEKRAKELEATFGCRMSPDIKQELL+C
Sbjct: 538 LLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHS 597
Query: 563 LSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSL 622
+VTDL+E+LGCLYESQEEEL K V+A FKEIS+HL N +V+ SF +KHC++LQK+SL
Sbjct: 598 -TVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRNLQKMSL 655
Query: 623 QVAKGVFLENYMDFELDIEFE-------------------SSNSNLKFLEVKQSFLSDSS 663
QV K EN E D E E SN +L L + SFLS S
Sbjct: 656 QVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASL 715
Query: 664 VRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLM 723
VRILC+ + TCHLQ+V KN++P A+R+ CLA G KT+T+LTL G+ + + M
Sbjct: 716 VRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDD--MFPA 773
Query: 724 LCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYK 783
LC++LR+ +CNL+YL L AT +QWA+ L+ NQSL + LS N LLDEGA LLY
Sbjct: 774 LCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYT 833
Query: 784 TMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLS 843
T+ PK FLQ LSLENC LTEA+CKDLAAVLVVS++LTHLCLAKNPIG+TGVKFLCEGL
Sbjct: 834 TLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLR 893
Query: 844 YPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALENPN 902
YP+CKLQTLVL C IT GC L++ LQE SL LDL +N I +G+ LC+AL P
Sbjct: 894 YPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPL 953
Query: 903 CNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSL 962
CNL+ L LW CS+ PF C+ L SAL NQ L TLDLGQN L SG+ LF L +G+L
Sbjct: 954 CNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTL 1013
Query: 963 KILRLKTYETNLEIKKLLEEVKEKNPKLTID 993
+ LRLK + N E+ KLLEE++EKNP+L ID
Sbjct: 1014 RTLRLKIDDFNDELNKLLEEIEEKNPQLIID 1044
Score = 63.9 bits (154), Expect = 7e-10
Identities = 59/201 (29%), Positives = 85/201 (42%), Gaps = 1/201 (0%)
Query: 809 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 868
DL ++ +K L L + + + + V+ LCE ++ C LQ +V + S R L
Sbjct: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLC 748
Query: 869 EALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALL 928
AL+ ++T L L N LC+ L +P CNL++L L SCS L AL
Sbjct: 749 LALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
Query: 929 SNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNP 988
NQ L ++L N L G L+ LR L+ L L+ K L V +
Sbjct: 809 VNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSR 868
Query: 989 KLTIDCNASGATAPPCCDFFC 1009
+LT C A F C
Sbjct: 869 ELTHLCLAKNPIGNTGVKFLC 889
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 561 bits (1447), Expect = e-160
Identities = 380/1080 (35%), Positives = 551/1080 (51%), Gaps = 102/1080 (9%)
Query: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
++ L LE+LN++EL +FK L +E TPW+EV++A + LA ++
Sbjct: 12 DFGLLLYLEELNKEELNTFKLFLKE-TMEPEHGLTPWNEVKKARREDLANLMKKYYPGEK 70
Query: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNS 126
+ ++ I +MNL +LC+ AK E+ Q D+ + G+ +ED E A G+ +RN
Sbjct: 71 AWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQE-AVLGDGTEYRNR 129
Query: 127 M-EKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFL-NPRTPRKLTPYTVVLHGPAGVGK 184
+ EK + W G ++FH + ++++ + L + P VVL G AGVGK
Sbjct: 130 IKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGK 189
Query: 185 TTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILA 243
TTL +K MLDW + +L +Y FYL+ +E++++ SFA+LISKDWP + I I+
Sbjct: 190 TTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMY 249
Query: 244 QAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRP 303
Q +LF++D DEL +C DW ++ PV L+ SLL++ MLP A+LLVTTR
Sbjct: 250 QPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL 309
Query: 304 RALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAP 363
+ L+ L + YV + G E+ R Y + F D+ AM+ F ++SN LF + P
Sbjct: 310 TTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVP 369
Query: 364 AVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF----------PQGAQLRGALR 413
VCW CT LK QMEKG D TC T T LF ++ S F P AQLR
Sbjct: 370 LVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLR---- 425
Query: 414 TLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQ 473
L +AA+G+W VF+RE+L RLG+ +SD+ F+D +I+++D + CY F HL Q+
Sbjct: 426 RLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQE 485
Query: 474 FLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKE 533
F A+FY L K E + D++ LL K+P L Q+ FLFGL NE R K+
Sbjct: 486 FFAAMFYML-KGSWEAGNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQ 543
Query: 534 LEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK--EVLGCLYESQEEELAKVVVAPF 591
LE TF C+MS IK +LLQC L N S + L E+ CLYE+Q++ + F
Sbjct: 544 LERTFNCKMSLKIKSKLLQCMEVL-GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCF 602
Query: 592 KEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFES------- 644
+++I++ ++ SF LKHC+ L+ + L V VF + + L
Sbjct: 603 PKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTV-VFEKKILKTSLPTNTWDGDRITHC 661
Query: 645 ---------SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 695
+N +L+ L++ S L S++ IL + C LQK+ +K +T +D
Sbjct: 662 WQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDI 721
Query: 696 CLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY 755
+ I K L HL L G + + LC+ L++ +C LQ LRL T
Sbjct: 722 STSLIHNKNLMHLDLKGSDIGDNGVK-SLCEALKHPECKLQTLRLESCNLTVFCCLNISN 780
Query: 756 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 815
L +QSL L LS N LLD+G LL + + PK +L+ LSLE+C LTEA C+ L+ L+
Sbjct: 781 ALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALI 840
Query: 816 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQE-- 873
+K+LTHLCLA N +GD GVK + + L + C L++LVL++C T L YLS +L
Sbjct: 841 SNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNK 900
Query: 874 -------------------------------------ACSLTN----------------- 879
C LTN
Sbjct: 901 SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLR 960
Query: 880 -LDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLD 937
LDL N + G+ ILC AL PNCN++ L L C L CQ L SAL+ N++L ++
Sbjct: 961 SLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMN 1020
Query: 938 LGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI--DCN 995
L QN L GI+KL+ VL+ L++L L + E +KLLE V NP L I DCN
Sbjct: 1021 LTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 466 bits (1200), Expect = e-131
Identities = 331/1030 (32%), Positives = 526/1030 (51%), Gaps = 91/1030 (8%)
Query: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
++ L LE+L ++E + FK L L+ L++ PW+EV++A ++LA +L+ E
Sbjct: 8 DFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQ 67
Query: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRN- 125
N T+ I ++M+ +LC E G + AK W +
Sbjct: 68 AWNITLRIFQKMDRKDLCMKVMRE-------------RTGYTKTYQAHAKQKFSRLWSSK 114
Query: 126 SMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKT 185
S+ + L ++ Q + D+ ++ F P + PR TV++ GP G+GKT
Sbjct: 115 SVTEIHLYFEEEVKQEECDHL-------DRLFAPKEAGKQPR-----TVIIQGPQGIGKT 162
Query: 186 TLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQ 244
TL K M+ W+D + Y FY C+EL + P S A+LIS++WP+ I I++Q
Sbjct: 163 TLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQ 222
Query: 245 AQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTR-- 302
+R+LFV+D +EL+ D+CGD +K+PV VLL SLL++KMLP A+LL+ +
Sbjct: 223 PERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPV 282
Query: 303 -PRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGS 361
P+ LRD +++ IY + GF E DR YF F D +AM AF L+R + LF +
Sbjct: 283 CPKELRDQVTISE--IY-QPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQ 339
Query: 362 APAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-----QLRGALRTL 415
P +CWI+CT+LK +M+KG+D TC + T ++ F+ + F P+GA Q + L+ L
Sbjct: 340 IPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKAL 399
Query: 416 SLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFL 475
LAA+G+W F +DL R GV ++D+ L IL + + Y F+H+ Q+F
Sbjct: 400 CSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFC 459
Query: 476 TALFYALEKEEGEDRDGHAWDIGDVQKLL-SGEERLKNPDLIQVGHFLFGLANEKRAKEL 534
ALFY L+ + VQ+LL + E+ + I +G FL GL N+K ++L
Sbjct: 460 AALFYLLKSHLDHPHPA----VRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKL 515
Query: 535 EATFGCRMSPDIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKE 593
+A FG ++S +IKQ++ QC L P D + CL+E Q+ K V +E
Sbjct: 516 DAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQE 575
Query: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLE-----NYMDFEL-----DIEFE 643
+ H+ + +++ ++ LK+C L+KL V + VF + + D+ L
Sbjct: 576 ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSV-QNVFKKEDEHSSTSDYSLICWHHICSVL 634
Query: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVT---------------P 688
+++ +L+ L+V+ S LS+S+ C+ + +C LQK+ I NV+ P
Sbjct: 635 TTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQP 694
Query: 689 DTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPE 748
D Y F TLT L+ R + LCD L N++ L L +P
Sbjct: 695 DLKYLSF--------TLTKLS--------RDDIRSLCDALNYPAGNVKELALVNCHLSPI 738
Query: 749 QWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCK 808
+L N+ L +L +S N LD G LL + + P L L L C L+E C+
Sbjct: 739 DCEVLAGLLTNNKKLTYLNVSCN-QLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCE 797
Query: 809 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 868
++ +L+ +K + +L L+ N + D G+K LCE L +PDC L +L L +C IT GC L+
Sbjct: 798 YISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLA 857
Query: 869 EALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSAL 927
AL +L L + N+I G+ +LC+AL + +C L+ L L C L C+ L S L
Sbjct: 858 SALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVL 917
Query: 928 LSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKN 987
++ L+ L+L N L +G++ L LR +L++L L+ + + E + LL +E+N
Sbjct: 918 TCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERN 977
Query: 988 PKLTI--DCN 995
P LTI DC+
Sbjct: 978 PNLTITDDCD 987
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 461 bits (1186), Expect = e-129
Identities = 331/1030 (32%), Positives = 503/1030 (48%), Gaps = 86/1030 (8%)
Query: 14 LEQLNEDELKSFKSLL--------WAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSEN 65
L L++ +L+ FK L W+ P + + PW+ + AD L+ +L +
Sbjct: 21 LMALDQYQLEEFKLCLEPQQLMDFWSAP-QGHFPRIPWANLRAADPLNLSFLLDEHFPKG 79
Query: 66 WIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNP---------------------- 103
+ I + MNLT LC+ +AEM E+ Q QE+ +P
Sbjct: 80 QAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQD 139
Query: 104 ----ELGDAEEDSE-----------------LAKPGEKEGWRNSMEKQSL-VWKNTFWQG 141
EL + EE++ L + + +R +M+ + L W N W
Sbjct: 140 PNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPK 199
Query: 142 DIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
D + ++ L+P R T+VL G AGVGKTTLA + ML W + L
Sbjct: 200 DHVYIRNTSKDEHEELQRLLDPNRTRAQAQ-TIVLVGRAGVGKTTLAMQAMLHWANGVLF 258
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FYLSC ++ M +FAELIS DWP+ I ++Q +++LF++DG +E+ +
Sbjct: 259 QQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIII 318
Query: 261 PPGALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQP 316
C DW ++ PV +L SLLK++++P A LL+T + +RDL+ P
Sbjct: 319 SESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNP 378
Query: 317 IYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQ 376
+V++ GF +D R YF+RHF D + + + +R N LF SAP VCW VC+ LK
Sbjct: 379 CFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQP 438
Query: 377 MEKGEDPVPTCLTRTGLFLRFLCSRFPQGA------QLRGALRTLSLLAAQGLWAQMSVF 430
+ D T T L+ F + F G R L LA +GLW+ F
Sbjct: 439 KVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTF 498
Query: 431 HREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDR 490
++ED E G++ + + +IL++ GC +F HLSFQ+F A+ + L EE +
Sbjct: 499 NKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVL--EEPREF 556
Query: 491 DGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQEL 550
H+ +++ LL K V F FGL N+ A+ELE T C++SP + +EL
Sbjct: 557 PPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEEL 616
Query: 551 LQCKAHLHANKPLSVT-DLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSF 609
L+ L + S+ + + CL+ESQEE+ K ++ E+ +++ E+ SF
Sbjct: 617 LKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSF 676
Query: 610 SLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFES-------------SNSNLKFLEVKQ 656
LKHC+ L KL L V+ + LE ++ +F+S +N NL L++
Sbjct: 677 CLKHCKRLNKLRLSVSSHI-LERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSN 735
Query: 657 SFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEW 716
S L SSV+ LC + C +QK+ K+VTP+ +D +A G LTHL + + +
Sbjct: 736 SKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSN-KL 794
Query: 717 ERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDE 776
T+ L+L LR+ CNL+YL L + + L + Q + L L N L D+
Sbjct: 795 GMTVPLIL-KALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDD 853
Query: 777 GAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVK 836
G LL +T PK L+ L L C+L +CK L+ L+ ++ LTHL L+KN + D GVK
Sbjct: 854 GIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVK 913
Query: 837 FLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILC 895
FLCE L PD LQ+L L CS T+ GC L+ AL ++ LDL N + G+ +LC
Sbjct: 914 FLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLC 973
Query: 896 QALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVL 955
+AL+ P+ L L L C+L CQHL S L S++ L L+L N L G+ L L
Sbjct: 974 EALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKAL 1032
Query: 956 RQRTGSLKIL 965
++ T L+ L
Sbjct: 1033 KKSTCRLQKL 1042
Score = 101 bits (251), Expect = 4e-21
Identities = 70/219 (31%), Positives = 109/219 (49%), Gaps = 3/219 (1%)
Query: 750 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 809
W L N++L L LS + L L + P+ +Q L+ ++ E +D
Sbjct: 715 WNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQD 773
Query: 810 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 869
L L + KLTHL + N +G T V + + L + C L+ L L++C+++ C+ L+
Sbjct: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
Query: 870 ALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALL 928
L +T L L N++ G+ +LC AL +P C L+ L LW C L C+HL ALL
Sbjct: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
Query: 929 SNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 967
N+ L L+L +N L G+ L L + G+L+ L L
Sbjct: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
Score = 70.9 bits (172), Expect = 6e-12
Identities = 57/182 (31%), Positives = 87/182 (47%), Gaps = 1/182 (0%)
Query: 810 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 869
+ + LV ++ L L L+ + + + VK LC L P CK+Q L + + + + L
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQDLII 776
Query: 870 ALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLS 929
ALQ LT+L+ S N++ + ++ +AL + CNLK+L L C+L CQ L L S
Sbjct: 777 ALQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836
Query: 930 NQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPK 989
Q + L LG N L GI L L +L+ L L + K L + +N
Sbjct: 837 IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS 896
Query: 990 LT 991
LT
Sbjct: 897 LT 898
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 446 bits (1148), Expect = e-125
Identities = 338/1043 (32%), Positives = 506/1043 (48%), Gaps = 82/1043 (7%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDH 670
+++C ++ LSL FL N E + E E + ++ + S + S ++ H
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH 724
Query: 671 VTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 730
+T S C R ++LT L L+ + + M +LC+ L++
Sbjct: 725 LTSSFC----------------RGLFSVLSTSQSLTELDLSDNSLGDPGMR-VLCETLQH 767
Query: 731 HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 790
CN++ L LG + E + VL +NQ L L LS N L D G LL +
Sbjct: 768 PGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLC 827
Query: 791 FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 850
L+ L L +C LT A C+DLA+VL S LT L + +N +GD+GV LCE P C LQ
Sbjct: 828 NLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQ 887
Query: 851 TLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLR 909
L L +T + C LS L +LT+L L N + +G+ +LC+ L +P+C L+ L
Sbjct: 888 KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLE 947
Query: 910 LWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKT 969
L +C+L C L + L S+Q L L LG N L G++ VL+Q++ L+ L L
Sbjct: 948 LDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
Query: 970 YETNLEIKKLLEEVKEKNPKLTI 992
N E K LE ++E+ P+LT+
Sbjct: 1008 MYFNYETKSALETLQEEKPELTV 1030
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 446 bits (1148), Expect = e-125
Identities = 338/1043 (32%), Positives = 506/1043 (48%), Gaps = 82/1043 (7%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDH 670
+++C ++ LSL FL N E + E E + ++ + S + S ++ H
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH 724
Query: 671 VTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 730
+T S C R ++LT L L+ + + M +LC+ L++
Sbjct: 725 LTSSFC----------------RGLFSVLSTSQSLTELDLSDNSLGDPGMR-VLCETLQH 767
Query: 731 HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 790
CN++ L LG + E + VL +NQ L L LS N L D G LL +
Sbjct: 768 PGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLC 827
Query: 791 FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 850
L+ L L +C LT A C+DLA+VL S LT L + +N +GD+GV LCE P C LQ
Sbjct: 828 NLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQ 887
Query: 851 TLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLR 909
L L +T + C LS L +LT+L L N + +G+ +LC+ L +P+C L+ L
Sbjct: 888 KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLE 947
Query: 910 LWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKT 969
L +C+L C L + L S+Q L L LG N L G++ VL+Q++ L+ L L
Sbjct: 948 LDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
Query: 970 YETNLEIKKLLEEVKEKNPKLTI 992
N E K LE ++E+ P+LT+
Sbjct: 1008 MYFNYETKSALETLQEEKPELTV 1030
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 443 bits (1139), Expect = e-124
Identities = 341/1058 (32%), Positives = 502/1058 (47%), Gaps = 82/1058 (7%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L T LE+L ELK FK L E K PW +E+A ++A++L+
Sbjct: 13 LSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
Query: 70 ATVNILEEMNLTELCKMAKAE-MMED---GQVQEIDNPELGDAEEDSELAKPGEKEGWRN 125
++ E +N +L + + E ++ D G + N E + +E +R+
Sbjct: 72 LALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRD 131
Query: 126 SMEKQ-SLVWKNTFWQGDIDNF------------HDDVTLRNQRFIP------------- 159
+ ++ L+ G+ N H + Q+ +
Sbjct: 132 YVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQA 191
Query: 160 -------FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLS 211
P R P TVV+ G AG+GK+ LA K MLDW D L Y FY++
Sbjct: 192 SPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYIN 251
Query: 212 CKELSRMGP-CSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDIC 270
C+E+++ CS +LI WPE + ++ +R+LF++DG DELK C
Sbjct: 252 CREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWC 311
Query: 271 GDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRR 330
WE+K+P +LL SL+++K+LP +LL+TTRP AL L L + P +V + GF E +R+
Sbjct: 312 LCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERK 371
Query: 331 AYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTR 390
YF ++F + +QA + F +R N LF + P VCW+VCT L+ Q+E G T T
Sbjct: 372 EYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTT 431
Query: 391 TGLFLRFLCSRF---PQGAQLRGA--LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDL 445
T +++ +L S P +L+ R L LAA GLW Q +F +DL + G+ D+
Sbjct: 432 TAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
Query: 446 RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505
FL+ +I ++D + YSFIHLSFQ+F A++Y L +EGE G A DV +LL+
Sbjct: 492 SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYIL--DEGE---GGAGPDQDVTRLLT 546
Query: 506 GEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQ-CKAHLHANKPLS 564
+ L FLFGL NE+ LE + ++SP IK +LLQ ++ ++
Sbjct: 547 EYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTL 606
Query: 565 VTDLKEVLGCLYESQEEELAKVVVAPFKEISI-HLTNTSEVMHCSFSLKHCQDLQKLSLQ 623
E CLYE QEEE + ++ F+ I + ++ + E M SF LK C+ Q L L
Sbjct: 607 QQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLY 666
Query: 624 VA-------------------------KGVFLENYMDFELDIEFESSNSNLKFLEVKQSF 658
A + V L+ Y E +N NL L + ++
Sbjct: 667 GATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYS--EHLAAALCTNPNLIELSLYRNA 724
Query: 659 LSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGHIEWE 717
L V++LC + C LQ + +K +A D A I K LT + L+G+
Sbjct: 725 LGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGF 784
Query: 718 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 777
MML LC+ LR+ +C LQ ++L E VL N L L L+ N L D G
Sbjct: 785 PGMML-LCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 843
Query: 778 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 837
LL + + P L+ L L+ CRLT A+C +LA+ L V++ L L L+ N +GD GV
Sbjct: 844 LRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLL 903
Query: 838 LCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQ 896
LCEGL +P CKLQTL L C + C LS LQ +L LDLS N + GLW+L +
Sbjct: 904 LCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAE 963
Query: 897 ALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLR 956
L++P C L+ L L SC L C++L L NQ L L L N L +G+ L L
Sbjct: 964 GLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLS 1023
Query: 957 QRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDC 994
L++L L + N L ++ P L I C
Sbjct: 1024 HPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 1061
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 442 bits (1138), Expect = e-124
Identities = 309/1000 (30%), Positives = 511/1000 (51%), Gaps = 61/1000 (6%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDV-LQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
L++L ++E FK LL PLE L+ PW+E+++A + +A++L T+
Sbjct: 15 LKELRKEEFWKFKELLKQ-PLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
Query: 73 NILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQ-S 131
N+ ++N +L A+ EM NP +R M++
Sbjct: 74 NLFLQINRKDLWTKAQEEMRNKL------NP-------------------YRKHMKETFQ 108
Query: 132 LVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
L+W+ ++F+ + T++N+ LN +TVVL GP G+GKTTL +K
Sbjct: 109 LIWEKETCLHVPEHFYKE-TMKNE--YKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKV 165
Query: 192 MLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
MLDW + NL + F+L+ E++ + S EL+S+DWPE + I I +Q +RILF
Sbjct: 166 MLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILF 225
Query: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
++DG ++LK L D+ DW +++P+P++L SLL++KMLP ++LL+ A++
Sbjct: 226 IMDGFEQLKFNL-QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHY 284
Query: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
+ + P +++ GF E ++++YF FG++ +A++ F +R N LF L P CW+VC
Sbjct: 285 FMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVC 344
Query: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQL------RGALRTLSLLAAQGLW 424
T +K ++E+GED T L+ FL + F G+Q R L++L LAA+G+W
Sbjct: 345 TCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIW 404
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
VF DL R G+ ES+ +++ +L++ C++F+HL Q+F A+FY L++
Sbjct: 405 TYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMFYLLKR 461
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
+ + IG + +L+ L QVG F+FG++ E+ LE +FG +S
Sbjct: 462 PKDDPNPA----IGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSK 517
Query: 545 DIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
D+KQE+ QC L +E+ L+E+QE+E V+ F+E+ I++ N
Sbjct: 518 DLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEH 577
Query: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLEN---YMDFELDIEFES-------SNSNLKFLE 653
++ SF LKHCQ L L + V + +F ++ D+ + + +N N + L+
Sbjct: 578 LVIASFCLKHCQHLTTLRMCV-ENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILD 636
Query: 654 VKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGH 713
++ + L D S+ ILC + + C L+K+ +V F A + L L+L G
Sbjct: 637 MENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELF-KAVLHNPHLKLLSLYG- 694
Query: 714 IEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVL 773
++ + LC+ L++ C ++ L LG + E + VL N LKHL L N L
Sbjct: 695 TSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPL 754
Query: 774 LDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDT 833
DEG LL + + L+ L L C LT SC ++ VL+ SK L+ L L N + D
Sbjct: 755 RDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDN 814
Query: 834 GVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLW 892
GV LC L +P C ++ L L C +T C+ ++ L L L L N+I G+
Sbjct: 815 GVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVR 874
Query: 893 ILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLF 952
LC AL++P+C L+ L L +C + C + +AL++ + L +L+L L ++ L
Sbjct: 875 QLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLC 934
Query: 953 GVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
L +L++L L + E +K+L V+EK P LTI
Sbjct: 935 EALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 441 bits (1133), Expect = e-123
Identities = 302/973 (31%), Positives = 486/973 (49%), Gaps = 51/973 (5%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
+ ++ +EL+ FK LL L W +VE A ++ +L+ + T N
Sbjct: 45 MRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSN 103
Query: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWR-NSMEKQSL 132
I MN ++C + + E+ E ++ +G+ + + E + G+ ++ N MEK
Sbjct: 104 IFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFP 163
Query: 133 VWKNTFWQGDIDNFHDDVTLRNQRFIP-FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
+W T W G+ +F R++ ++P L P+ P+ P TV + G G+GKT LAKK
Sbjct: 164 IWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKV 223
Query: 192 MLDWTDCNLSPTLRY-AFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
M +W R+ AFY C+E+++ SF+ELI + WP QD + I+++ ++L
Sbjct: 224 MFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLL 283
Query: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
++DG +EL ++D+ DW +K P VLL SLL + MLP A LL+ R + + +
Sbjct: 284 LLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCK 343
Query: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
L + P V + GF ++ YF +FG ++ + N LF + P VCW+VC
Sbjct: 344 PLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVC 403
Query: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ------LRGALRTLSLLAAQGLW 424
+ LK QME+G + +C T +F+R++ S FP A+ + L L LAA +W
Sbjct: 404 SGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMW 463
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
+ V +EDLE + ++ + FL ILR+ + Y F ++FQ+F ALFY L
Sbjct: 464 HRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCF 523
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
+ ++ H ++Q+L++ K+ L +G FLFG NE A +E +F C++S
Sbjct: 524 PQ-RLKNFHVLSHVNIQRLIASPRGSKS-YLSHMGLFLFGFLNEACASAVEQSFQCKVSF 581
Query: 545 DIKQELLQCKAHLH-ANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
K++LL+ LH + P + + ++ CL+E +EE + + ++ + + N E
Sbjct: 582 GNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKE 641
Query: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDF------------------------ELD 639
V +F LK CQ L ++ L V N+M+ +L
Sbjct: 642 VQVSAFCLKRCQYLHEVELTVTL-----NFMNVWKLSSSSHPGSEAPESNGLHRWWQDLC 696
Query: 640 IEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAF 699
F ++N L+ L + S L ++ L + C LQK+ ++ V +D
Sbjct: 697 SVF-ATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVL 755
Query: 700 IGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKA 759
G + L +L + H+E E + +LC +LR+ +C LQ LRL ATP W + L+
Sbjct: 756 TGNQHLRYLEIQ-HVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQG 814
Query: 760 NQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKK 819
N LK L L N L + GA L L+ LS+ENC LT+ +C+ LA+ L SK
Sbjct: 815 NGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQLTCESLASCLRQSKM 868
Query: 820 LTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTN 879
LTHL LA+N + D G K + L + C LQ LVL++C +T C+ + AL + +L +
Sbjct: 869 LTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKS 928
Query: 880 LDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDL 938
LDLS N + G+ +LC+AL+NP+C L+ L L +C CQ + S L NQ L LDL
Sbjct: 929 LDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDL 988
Query: 939 GQNHLWKSGIIKL 951
+N + GI+ L
Sbjct: 989 SKNAIGVYGILTL 1001
Score = 77.8 bits (190), Expect = 5e-14
Identities = 62/199 (31%), Positives = 95/199 (47%), Gaps = 8/199 (4%)
Query: 646 NSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVT-PDTAYRDFCLAFIGKKT 704
N +LK L ++++ L + C S L+++ I+N K
Sbjct: 815 NGHLKTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKM 868
Query: 705 LTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLK 764
LTHL+LA + + + + L + +C LQ L L T + L N++LK
Sbjct: 869 LTHLSLAENALKDEGAK-HIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
Query: 765 HLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLC 824
L LS N L D+G +LL + + P LQ+L LENC T C+ +A++L ++ L HL
Sbjct: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
Query: 825 LAKNPIGDTGVKFLCEGLS 843
L+KN IG G+ LCE S
Sbjct: 988 LSKNAIGVYGILTLCEAFS 1006
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 405 bits (1042), Expect = e-113
Identities = 310/961 (32%), Positives = 462/961 (48%), Gaps = 82/961 (8%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDH 670
+++C ++ LSL FL N E + E E + ++ + S + S ++ H
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH 724
Query: 671 VTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 730
+T S C R ++LT L L+ + + M +LC+ L++
Sbjct: 725 LTSSFC----------------RGLFSVLSTSQSLTELDLSDNSLGDPGMR-VLCETLQH 767
Query: 731 HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 790
CN++ L LG + E + VL +NQ L L LS N L D G LL +
Sbjct: 768 PGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLC 827
Query: 791 FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 850
L+ L L N LT C L++VL ++ LTHL L N +GD G+K LCEGL +PDCKLQ
Sbjct: 828 NLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
Query: 851 TLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLR 909
L L C++T C LS L + SL L L N + G+ + C+ L+ +C L++L
Sbjct: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
Query: 910 L 910
L
Sbjct: 948 L 948
Score = 142 bits (357), Expect = 2e-33
Identities = 88/240 (36%), Positives = 132/240 (55%), Gaps = 1/240 (0%)
Query: 754 FYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAV 813
F VL +QSL L LS N L D G +L +T+ P ++ L L C L+ C D++ V
Sbjct: 734 FSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLV 793
Query: 814 LVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQE 873
L ++KL L L+ N +GD G++ LC GL + C L+ L L +T + C LS L
Sbjct: 794 LSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLST 853
Query: 874 ACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 932
+LT+L L N + +G+ +LC+ L +P+C L+ L L +C+L C L + L S+Q
Sbjct: 854 NQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQS 913
Query: 933 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
L L LG N L G++ VL+Q++ L+ L L N E K LE ++E+ P+LT+
Sbjct: 914 LRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 405 bits (1042), Expect = e-113
Identities = 311/961 (32%), Positives = 456/961 (47%), Gaps = 82/961 (8%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDH 670
+++C ++ LSL FL N + E E + L++ Q L SS C H
Sbjct: 670 IENCHRVESLSLG-----FLHN-----MPKEEEEEEKEGRHLDMVQCVLPSSS-HAACSH 718
Query: 671 VTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 730
C L D L + L L L+ + + + L LC L++
Sbjct: 719 -GLGRCGLS---------HECCFDISLVLSSNQKLVELDLSDNALGDFGIRL-LCVGLKH 767
Query: 731 HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 790
CNL+ L L C T + VL + SL L + N L D G +L + P+
Sbjct: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
Query: 791 FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 850
LQ L L N LT C L++VL ++ LTHL L N +GD G+K LCEGL +PDCKLQ
Sbjct: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
Query: 851 TLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLR 909
L L C++T C LS L + SL L L N + G+ + C+ L+ +C L++L
Sbjct: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
Query: 910 L 910
L
Sbjct: 948 L 948
Score = 147 bits (370), Expect = 6e-35
Identities = 93/238 (39%), Positives = 130/238 (54%), Gaps = 1/238 (0%)
Query: 756 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 815
VL +NQ L L LS N L D G LL + L+ L L +C LT A C+DLA+VL
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 795
Query: 816 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEAC 875
S LT L + +N +GD+GV LCE P C LQ L L +T + C LS L
Sbjct: 796 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 855
Query: 876 SLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLE 934
+LT+L L N + +G+ +LC+ L +P+C L+ L L +C+L C L + L S+Q L
Sbjct: 856 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 915
Query: 935 TLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
L LG N L G++ VL+Q++ L+ L L N E K LE ++E+ P+LT+
Sbjct: 916 KLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 397 bits (1019), Expect = e-110
Identities = 307/1056 (29%), Positives = 501/1056 (47%), Gaps = 115/1056 (10%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
LQ L +L+++E ++FK LL E P E+E A+ + LA +L +
Sbjct: 65 LQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWA 124
Query: 70 ATVNILEEMNLTELCKMAKAEMM----EDGQVQEIDN-------PELGDA-EEDS----- 112
+++I E MNL L + A+ +M ED + D P + A ++DS
Sbjct: 125 TSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAE 184
Query: 113 ----ELAKPGEKEGWR----------NSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFI 158
E+++ E+EG +ME++ T QG + D + +F
Sbjct: 185 TKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFA 244
Query: 159 PFLNPRTPRKLT----------------------PYTVVLHGPAGVGKTTLAKKCMLDWT 196
+ R + T P TVVLHG +G+GK+ LA++ +L W
Sbjct: 245 EEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWA 304
Query: 197 DCNLSPTL-RYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGL 255
L + Y F+L +E+ R S E IS++WP+ Q + I+++ +R+LF++DG
Sbjct: 305 QGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGF 364
Query: 256 DELKVPPGALIQD---ICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLL 312
D+L G+++ + +C DW +K+P L+ SLL++ +LP + L+VT R L+
Sbjct: 365 DDL----GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE 420
Query: 313 AQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTT 372
P Y+ V G E R L E Q + + +N L PAV ++C
Sbjct: 421 VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA 480
Query: 373 LKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-------QLRGALRTLSLLAAQGLW 424
L+LQ GE P T TGL F+ + P+G + R L+ +A +G+W
Sbjct: 481 LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW 540
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
+ SVF +DL G+ ES+LR +IL D + Y+F HLS Q F AL+Y LE
Sbjct: 541 NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG 600
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVG---------HFLFGLANEKRAKELE 535
E I L E+ ++ +L Q G FLFGL +E + LE
Sbjct: 601 LE----------IEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLE 650
Query: 536 ATFGCRMSPDIKQELLQCKAHLHANKPLSVT--DLKEVLGCLYESQEEELAKVVVAPFKE 593
GC + +KQ+LL + L +P + T D + CL+E+Q++E ++ + F+E
Sbjct: 651 VLLGCPVPLGVKQKLLHWVSLL-GQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQE 709
Query: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLEN-----------YMDFELDIEF 642
+ + + +++ SF L+HC L+K+ + V KG+F + +M + IE
Sbjct: 710 VWLPINQNLDLIASSFCLQHCPYLRKIRVDV-KGIFPRDESAEACPVVPLWMRDKTLIEE 768
Query: 643 E--------SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRD 694
+ ++ +L+ L++ S L++ +++ LC + TC +Q + +N +
Sbjct: 769 QWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQH 828
Query: 695 FCLAFIGKKTLTHLTLAG-HIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEF 753
+ + L L L G H++ E M C+ L++ KC L+ LRL T + +
Sbjct: 829 LWRIVMANRNLRSLNLGGTHLKEEDVRMA--CEALKHPKCLLESLRLDCCGLTHACYLKI 886
Query: 754 FYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAV 813
+L + SLK L L+ N + D+G M L + + LQ L LE+C +T C+ LA+
Sbjct: 887 SQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASA 946
Query: 814 LVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQE 873
LV ++ LTHLCL+ N +G+ GV LC + P C LQ L+L QC + GC +L+ AL
Sbjct: 947 LVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMG 1006
Query: 874 ACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 932
LT+L LS+N + G+ +LC+ + P+C+L+ L L C L C+ L + ++
Sbjct: 1007 NSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRH 1066
Query: 933 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLK 968
L++LDL N L G+ L L+Q+ L L LK
Sbjct: 1067 LKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLK 1102
Score = 123 bits (309), Expect = 8e-28
Identities = 93/271 (34%), Positives = 133/271 (49%), Gaps = 5/271 (1%)
Query: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGK 702
+++ +LK L + + ++D V L D + S C LQK+ +++ T + A +
Sbjct: 891 TTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSN 950
Query: 703 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV-LKANQ 761
++LTHL L+ + + L LC +R C+LQ L L C F + L N
Sbjct: 951 RSLTHLCLSNNSLGNEGVNL-LCRSMRLPHCSLQRLMLN-QCHLDTAGCGFLALALMGNS 1008
Query: 762 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 821
L HL LS N + D G LL + M P LQ L L C LT A C+ L+ V+ S+ L
Sbjct: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068
Query: 822 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 881
L L N +GD GV LCEGL + L L L+ C +T C LS AL LT+L+
Sbjct: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLN 1128
Query: 882 LSINQIA-RGLWILCQALENPNCNLKHLRLW 911
L N + +G+ LC A P NL+ + LW
Sbjct: 1129 LVQNNFSPKGMMKLCSAFACPTSNLQIIGLW 1159
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 371 bits (952), Expect = e-102
Identities = 291/906 (32%), Positives = 424/906 (46%), Gaps = 81/906 (8%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDH 670
+++C ++ LSL FL N + E E + L++ Q L SS C H
Sbjct: 670 IENCHRVESLSLG-----FLHN-----MPKEEEEEEKEGRHLDMVQCVLPSSS-HAACSH 718
Query: 671 VTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 730
C L D L + L L L+ + + + L LC L++
Sbjct: 719 -GLGRCGLS---------HECCFDISLVLSSNQKLVELDLSDNALGDFGIRL-LCVGLKH 767
Query: 731 HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 790
CNL+ L L T + VL NQ+L HL L N L D+G LL + + P
Sbjct: 768 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 827
Query: 791 FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 850
LQ+L L+NC LT C DL+ +L S+ L L L N +GD GV CE L C LQ
Sbjct: 828 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 887
Query: 851 TLVLQQ 856
L L +
Sbjct: 888 NLGLSE 893
Score = 119 bits (299), Expect = 1e-26
Identities = 71/197 (36%), Positives = 109/197 (55%), Gaps = 1/197 (0%)
Query: 797 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 856
L C L+ C D++ VL ++KL L L+ N +GD G++ LC GL + C L+ L L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 857 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSL 915
+T + C LS L +LT+L L N + +G+ +LC+ L +P+C L+ L L +C+L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 916 MPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLE 975
C L + L S+Q L L LG N L G++ VL+Q++ L+ L L N E
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYE 899
Query: 976 IKKLLEEVKEKNPKLTI 992
K LE ++E+ P+LT+
Sbjct: 900 TKSALETLQEEKPELTV 916
Score = 106 bits (264), Expect = 1e-22
Identities = 65/156 (41%), Positives = 86/156 (55%), Gaps = 1/156 (0%)
Query: 756 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 815
VL +NQ L L LS N L D G LL + L+ L L N LT C L++VL
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLS 795
Query: 816 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEAC 875
++ LTHL L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L +
Sbjct: 796 TNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ 855
Query: 876 SLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 910
SL L L N + G+ + C+ L+ +C L++L L
Sbjct: 856 SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 343 bits (881), Expect = 4e-94
Identities = 288/1015 (28%), Positives = 457/1015 (45%), Gaps = 69/1015 (6%)
Query: 3 SPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTS 62
S ++ L LE L++ E +SFK L L+ L + P ++ + ++LA +L +
Sbjct: 4 SDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLPISY 60
Query: 63 SENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEG 122
+I N +I M +LC+ +G + E K +
Sbjct: 61 EGQYIWNMLFSIFSMMRKEDLCRKI-----------------IGRRNRNQEACKAVMRR- 102
Query: 123 WRNSMEKQSLVWKN-TFWQGDIDNFHD---DVTLRNQRFIPFLNPRTPRKLTPYTVVLHG 178
K L W++ TF + F D DV Q + + L V L G
Sbjct: 103 ------KFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLN---VFLMG 153
Query: 179 PAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDD 237
GKT + +L W + + Y +L+ E+++M S AELI+KDWP+ Q
Sbjct: 154 ERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAP 213
Query: 238 IPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAAL 297
I IL+ +++LF+++ LD ++ +C + +K P+PVLL SLLKRKM P
Sbjct: 214 IADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWF 273
Query: 298 LVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALF 357
L+++RP +++ ++ R YF F D +A A +L+ + L
Sbjct: 274 LISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILV 333
Query: 358 QLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLR------GA 411
L +CWI CT LK QM+KG D C T T L FL A L G
Sbjct: 334 GLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGL 393
Query: 412 LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSF 471
L+ L LLAA GL+ F EDL +G E+D+ + +IL K Y FIHL+
Sbjct: 394 LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNV 453
Query: 472 QQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRA 531
Q+F TA+ + + G E+R + D QV F+FGL N R
Sbjct: 454 QEFCTAIAFLMAVPNYLIPSG---------SREYKEKREQYSDFNQVFTFIFGLLNANRR 504
Query: 532 KELEATFGCR--MSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVA 589
K LE +FG + M K + HL + P +T + CLYE++EEE K +V
Sbjct: 505 KILETSFGYQLPMVDSFKWYSVGYMKHLDRD-PEKLTHHMPLFYCLYENREEEFVKTIVD 563
Query: 590 PFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVF-------------LENYMDF 636
E++++L + ++M + L +C L+ L L V + +F +++ + +
Sbjct: 564 ALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR-IFQNKEPLIRPTASQMKSLVYW 622
Query: 637 ELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFC 696
+ +L+ L + + L+ S RIL + S+C L+ +++ V+ + + D
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLL 682
Query: 697 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 756
A ++LT+L++ M +L D+L C + +L L + E +
Sbjct: 683 KALARNRSLTYLSI-NCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
Query: 757 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 816
L + SL+ L LS+N L +G +L + P L L L C LTE C L VL+
Sbjct: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
Query: 817 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACS 876
S L L L N + + GV + L +P C+L+ L L C + C+Y++ +
Sbjct: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
Query: 877 LTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLET 935
L +L++ N+I G+ +LC L +PNC L ++ L C L C+ L S L +N+ LE
Sbjct: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
Query: 936 LDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 990
L+L QNHL G+ KL L LK++ L N + ++LL VKE+ P L
Sbjct: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSL 976
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 330 bits (846), Expect = 4e-90
Identities = 247/714 (34%), Positives = 364/714 (50%), Gaps = 77/714 (10%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------ 769
Query: 629 FLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTP 688
+E +Q RST V + P
Sbjct: 770 -----------------------IEGRQH---------------RSTWSPTMVVLFRWVP 791
Query: 689 DT-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCAT 746
T AY + + + L L L+G+ + + LC LR +C L+ LRL G T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 747 PEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEAS 806
E + + L+ANQ+L L LS NVL D GA L + + +P LQ L L +C LT
Sbjct: 851 AEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDC 910
Query: 807 CKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSIT 860
C+DLA+VL S L L L +N + D GV+ LCEGL +P CKL L L Q +++
Sbjct: 911 CQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Score = 113 bits (282), Expect = 1e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)
Query: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 910
L+ L + SL LDL N + G+ +LC+ L +P C L L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 105 bits (263), Expect = 2e-22
Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)
Query: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 978
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL +T L E+++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
Query: 979 LLEEVKEKNPKLTI 992
L ++++ P+L I
Sbjct: 970 ELRALEQEKPQLLI 983
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 330 bits (846), Expect = 4e-90
Identities = 247/714 (34%), Positives = 364/714 (50%), Gaps = 77/714 (10%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------ 769
Query: 629 FLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTP 688
+E +Q RST V + P
Sbjct: 770 -----------------------IEGRQH---------------RSTWSPTMVVLFRWVP 791
Query: 689 DT-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCAT 746
T AY + + + L L L+G+ + + LC LR +C L+ LRL G T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 747 PEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEAS 806
E + + L+ANQ+L L LS NVL D GA L + + +P LQ L L +C LT
Sbjct: 851 AEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDC 910
Query: 807 CKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSIT 860
C+DLA+VL S L L L +N + D GV+ LCEGL +P CKL L L Q +++
Sbjct: 911 CQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Score = 113 bits (282), Expect = 1e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)
Query: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 910
L+ L + SL LDL N + G+ +LC+ L +P C L L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 105 bits (263), Expect = 2e-22
Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)
Query: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 978
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL +T L E+++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
Query: 979 LLEEVKEKNPKLTI 992
L ++++ P+L I
Sbjct: 970 ELRALEQEKPQLLI 983
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 330 bits (846), Expect = 4e-90
Identities = 247/714 (34%), Positives = 364/714 (50%), Gaps = 77/714 (10%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------ 769
Query: 629 FLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTP 688
+E +Q RST V + P
Sbjct: 770 -----------------------IEGRQH---------------RSTWSPTMVVLFRWVP 791
Query: 689 DT-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCAT 746
T AY + + + L L L+G+ + + LC LR +C L+ LRL G T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 747 PEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEAS 806
E + + L+ANQ+L L LS NVL D GA L + + +P LQ L L +C LT
Sbjct: 851 AEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDC 910
Query: 807 CKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSIT 860
C+DLA+VL S L L L +N + D GV+ LCEGL +P CKL L L Q +++
Sbjct: 911 CQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Score = 113 bits (282), Expect = 1e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)
Query: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 910
L+ L + SL LDL N + G+ +LC+ L +P C L L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 105 bits (263), Expect = 2e-22
Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)
Query: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 978
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL +T L E+++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
Query: 979 LLEEVKEKNPKLTI 992
L ++++ P+L I
Sbjct: 970 ELRALEQEKPQLLI 983
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 327 bits (837), Expect = 5e-89
Identities = 244/703 (34%), Positives = 358/703 (50%), Gaps = 77/703 (10%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------ 769
Query: 629 FLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTP 688
+E +Q RST V + P
Sbjct: 770 -----------------------IEGRQH---------------RSTWSPTMVVLFRWVP 791
Query: 689 DT-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCAT 746
T AY + + + L L L+G+ + + LC LR +C L+ LRL G T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 747 PEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEAS 806
E + + L+ANQ+L L LS NVL D GA L + + +P LQ L L +C LT
Sbjct: 851 AEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDC 910
Query: 807 CKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKL 849
C+DLA+VL S L L L +N + D GV+ LCEGL +P CKL
Sbjct: 911 CQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 113 bits (282), Expect = 1e-24
Identities = 70/172 (40%), Positives = 91/172 (52%), Gaps = 3/172 (1%)
Query: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLM 916
L+ L + SL LDL N + G+ +LC+ L +P C L +RL S+M
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLGKPSVM 962
Score = 97.8 bits (242), Expect = 4e-20
Identities = 65/167 (38%), Positives = 93/167 (55%), Gaps = 3/167 (1%)
Query: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 967
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRL 956
Score = 53.9 bits (128), Expect = 7e-07
Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)
Query: 838 LCEGLSYPDCKLQTLVL--QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARG-LWIL 894
L EG + T+V+ + +T + L L+ +L LDLS N ++ + L
Sbjct: 769 LIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL 828
Query: 895 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGV 954
C+ L P C L+ LRL C L C+ L L +NQ L LDL N L +G L
Sbjct: 829 CKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQR 888
Query: 955 LRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 990
LRQ + L+ L+L + + + L V +P L
Sbjct: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
Score = 30.4 bits (67), Expect = 8.8
Identities = 15/47 (31%), Positives = 28/47 (59%)
Query: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDT 690
S++ +LK L+++Q+ L D VR+LC+ + C L ++ +V T
Sbjct: 919 SASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPT 965
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 327 bits (837), Expect = 5e-89
Identities = 244/703 (34%), Positives = 358/703 (50%), Gaps = 77/703 (10%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+ + + E++ C+F +K + ++KL L
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL------ 769
Query: 629 FLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTP 688
+E +Q RST V + P
Sbjct: 770 -----------------------IEGRQH---------------RSTWSPTMVVLFRWVP 791
Query: 689 DT-AYRDFCLAFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCAT 746
T AY + + + L L L+G+ + + LC LR +C L+ LRL G T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGN-SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 747 PEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEAS 806
E + + L+ANQ+L L LS NVL D GA L + + +P LQ L L +C LT
Sbjct: 851 AEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDC 910
Query: 807 CKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKL 849
C+DLA+VL S L L L +N + D GV+ LCEGL +P CKL
Sbjct: 911 CQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 113 bits (282), Expect = 1e-24
Identities = 70/172 (40%), Positives = 91/172 (52%), Gaps = 3/172 (1%)
Query: 746 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 805
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 806 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 865
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 866 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLM 916
L+ L + SL LDL N + G+ +LC+ L +P C L +RL S+M
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLGKPSVM 962
Score = 97.8 bits (242), Expect = 4e-20
Identities = 65/167 (38%), Positives = 93/167 (55%), Gaps = 3/167 (1%)
Query: 802 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 861
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 862 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 920
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 921 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 967
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRL 956
Score = 53.9 bits (128), Expect = 7e-07
Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)
Query: 838 LCEGLSYPDCKLQTLVL--QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARG-LWIL 894
L EG + T+V+ + +T + L L+ +L LDLS N ++ + L
Sbjct: 769 LIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL 828
Query: 895 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGV 954
C+ L P C L+ LRL C L C+ L L +NQ L LDL N L +G L
Sbjct: 829 CKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQR 888
Query: 955 LRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 990
LRQ + L+ L+L + + + L V +P L
Sbjct: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
Score = 30.4 bits (67), Expect = 8.8
Identities = 15/47 (31%), Positives = 28/47 (59%)
Query: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDT 690
S++ +LK L+++Q+ L D VR+LC+ + C L ++ +V T
Sbjct: 919 SASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPT 965
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 255 bits (651), Expect = 2e-67
Identities = 221/698 (31%), Positives = 323/698 (46%), Gaps = 49/698 (7%)
Query: 171 PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL-SRMGPCSFAELIS 228
P TVVL GPAG+GKT AKK + DW L + +AF++ C EL R G S A+LI
Sbjct: 195 PLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLIL 254
Query: 229 KDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLK 288
P+ +P +LAQ QR+LF++DG DEL G +E VL G LL
Sbjct: 255 DQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVL-GGLLS 313
Query: 289 RKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFE 348
+ +LP A LLVTTR A LQ P V GF ++D++ YF + F DE +A RA+
Sbjct: 314 KALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYR 373
Query: 349 LMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCS-----RFP 403
++ N LF L P VCWIVCT L+ Q+E G D T T T ++L F+ S
Sbjct: 374 FVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVA 433
Query: 404 QGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLR-LFLDGDILRQDRVSKG 462
G +L+G LR L LA +G+ + + F ++LE+L ++ S ++ LFL L ++
Sbjct: 434 DGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEV 493
Query: 463 CYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFL 522
Y FI SFQ+FL AL Y LE + G R G V LL G+ + + L+ FL
Sbjct: 494 TYQFIDQSFQEFLAALSYLLE-DGGVPRTA----AGGVGTLLRGDAQ-PHSHLVLTTRFL 547
Query: 523 FGLANEKRAKELEATFGCRMSPDIKQELLQ------------CKAHLHANKPLSVTDLK- 569
FGL + +R +++E FGC +S +KQE L+ K L T+
Sbjct: 548 FGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPE 607
Query: 570 ------------EVLGCLYESQEEELAKVVVAPFKEISIHLTN--TSEVMHCSFSLKHCQ 615
E+L CLYE+QE+ + + F E+++ +V S+ ++ C
Sbjct: 608 EEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCP 667
Query: 616 DLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRST 675
Q L L + V + L ++S + L S + L +T
Sbjct: 668 AGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPL 727
Query: 676 CHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCN 734
CHL + + + PD RD A LT L L H + ML + L +C
Sbjct: 728 CHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLL-HNRLSEAGLRMLSEGLAWPQCR 786
Query: 735 LQYLRLGGHCATPEQWAEFFY-VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQ 793
+Q +R+ P++ ++ +L+ + +L L LS L L + LQ
Sbjct: 787 VQTVRV--QLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQ 844
Query: 794 MLSLENCRLTEASCKDLAAVLVVSKKL--THLCLAKNP 829
LSL + L+E S ++L AV L TH L +P
Sbjct: 845 TLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHP 882
Score = 84.0 bits (206), Expect = 7e-16
Identities = 53/144 (36%), Positives = 81/144 (56%), Gaps = 2/144 (1%)
Query: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
L++ MT P L L+L +C+L +A C+DL+ L + LT L L N + + G++ L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
GL++P C++QT V Q + G +YL L+++ +LT LDLS Q+ A + LC L+
Sbjct: 779 GLAWPQCRVQT-VRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 900 NPNCNLKHLRLWSCSLMPFYCQHL 923
+ C L+ L L S L Q L
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQEL 861
Score = 61.2 bits (147), Expect = 5e-09
Identities = 53/168 (31%), Positives = 80/168 (47%), Gaps = 3/168 (1%)
Query: 838 LCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQ 896
L + ++ P C L +L L C + CR LSEAL+ A +LT L L N+++ GL +L +
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 897 ALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLR 956
L P C ++ +R+ Q+L L + L TLDL L + L VL+
Sbjct: 779 GLAWPQCRVQTVRVQLPDPQRGL-QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 957 QRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDCNA-SGATAPP 1003
+ L+ L L + E + + + L+ VK P L I A G PP
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHPQPP 885
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 219 bits (557), Expect = 1e-56
Identities = 181/621 (29%), Positives = 287/621 (46%), Gaps = 52/621 (8%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
L L E++ K K L L + E+E LAE+L++ E +
Sbjct: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
Query: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKE-----GWRNSME 128
L+ MNL EL + D +E+ + EE E G +S
Sbjct: 77 GLKVMNLLELVDQLSHICLHD--YREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSES 134
Query: 129 KQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLA 188
+SL F + ++++ VT+ + L P VVL G AG GKTTLA
Sbjct: 135 PESLACP--FPEQELES----VTVE-----ALFDSGEKPSLAPSLVVLQGSAGTGKTTLA 183
Query: 189 KKCMLDWTDCNLSP-TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQR 247
+K +LDW L P Y FY+SCKE+ + +L+ + Q + IL Q +R
Sbjct: 184 RKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPER 243
Query: 248 ILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALR 307
+LF++DG DEL+ P ++ P LL L++R LP +LL+TTRP ALR
Sbjct: 244 LLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALR 298
Query: 308 DLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCW 367
+L+ L +Q +V + GF EE+R YF +F DE QA RAF++++ N L++ P +CW
Sbjct: 299 NLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICW 358
Query: 368 IVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP-------QGAQLRGALRTLSLLAA 420
+VC+ L+ QME+G+ + T T +F+ ++ + P LR+L LAA
Sbjct: 359 VVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAA 418
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
+G+ Q +F +L + + L FL + + K YSF H+SFQ F A+ Y
Sbjct: 419 EGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSY 478
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
+ +E + R G +VQ+LL +E+ N ++ FL ++ + LE F
Sbjct: 479 LV--KEDQSRLGKE-SRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCF 535
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
R+SP + Q+L K + + K DL+ LYE++ + L K +
Sbjct: 536 RISPCLAQDLKHFKEQMESMKHNRTWDLE---FSLYEAKIKNLVKGI------------- 579
Query: 601 TSEVMHCSFSLKHCQDLQKLS 621
++ + SF +KH + + S
Sbjct: 580 --QMNNVSFKIKHSNEKKSQS 598
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 144 bits (364), Expect = 3e-34
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 3/346 (0%)
Query: 649 LKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLTH 707
L+ L + + L D+ +++LC+ + C L+K++++ + A + + + K
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 708 LTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLR 767
LT++ + + + +LC L++ C L+ L+L T + + ++ + SL+ L
Sbjct: 175 LTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELA 233
Query: 768 LSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAK 827
L +N L D G L + P L+ L + C +T C DL VL + L L LA
Sbjct: 234 LGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAG 293
Query: 828 NPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI 887
N +GD G + LCE L P C+L++L ++ CS T C + S L + L L +S N++
Sbjct: 294 NELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRL 353
Query: 888 A-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKS 946
G+ LCQ L P L+ L L C + C L + LL+N L LDL N L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 947 GIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 121 bits (303), Expect = 4e-27
Identities = 88/267 (32%), Positives = 134/267 (50%), Gaps = 5/267 (1%)
Query: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLAFIGKKTL 705
+ K L V + ++++ VR+LC + S C L+ K+E VT D RD C K +L
Sbjct: 171 DFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGIVASKASL 229
Query: 706 THLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKH 765
L L G + M LC L + L+ L + T + + VL+A +SLK
Sbjct: 230 RELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825
L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++ L L +
Sbjct: 289 LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQI 348
Query: 826 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 885
+ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL LDLS N
Sbjct: 349 SNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNN 408
Query: 886 QIA-RGLWILCQALENPNCNLKHLRLW 911
+ G+ L +++ P C L+ L L+
Sbjct: 409 CLGDAGILQLVESVRQPGCLLEQLVLY 435
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 900 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 959
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 960 GSLKIL 965
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 2e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 728 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 787
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 788 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 847
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 848 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 906
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 907 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 966
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 967 LKT 969
+K+
Sbjct: 320 VKS 322
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 2/154 (1%)
Query: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTA-YRDFCLAFIGKK 703
+ +LK L + + L D R+LC+ + C L+ + +K+ + A F +
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
L L ++ + E + LC L L+ L L + + L AN SL
Sbjct: 342 FLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797
+ L LS N L D G + L +++ +P L+ L L
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 144 bits (364), Expect = 3e-34
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 3/346 (0%)
Query: 649 LKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLTH 707
L+ L + + L D+ +++LC+ + C L+K++++ + A + + + K
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 708 LTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLR 767
LT++ + + + +LC L++ C L+ L+L T + + ++ + SL+ L
Sbjct: 175 LTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELA 233
Query: 768 LSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAK 827
L +N L D G L + P L+ L + C +T C DL VL + L L LA
Sbjct: 234 LGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAG 293
Query: 828 NPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI 887
N +GD G + LCE L P C+L++L ++ CS T C + S L + L L +S N++
Sbjct: 294 NELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRL 353
Query: 888 A-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKS 946
G+ LCQ L P L+ L L C + C L + LL+N L LDL N L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 947 GIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 121 bits (303), Expect = 4e-27
Identities = 88/267 (32%), Positives = 134/267 (50%), Gaps = 5/267 (1%)
Query: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLAFIGKKTL 705
+ K L V + ++++ VR+LC + S C L+ K+E VT D RD C K +L
Sbjct: 171 DFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGIVASKASL 229
Query: 706 THLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKH 765
L L G + M LC L + L+ L + T + + VL+A +SLK
Sbjct: 230 RELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825
L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++ L L +
Sbjct: 289 LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQI 348
Query: 826 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 885
+ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL LDLS N
Sbjct: 349 SNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNN 408
Query: 886 QIA-RGLWILCQALENPNCNLKHLRLW 911
+ G+ L +++ P C L+ L L+
Sbjct: 409 CLGDAGILQLVESVRQPGCLLEQLVLY 435
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 900 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 959
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 960 GSLKIL 965
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 2e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 728 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 787
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 788 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 847
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 848 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 906
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 907 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 966
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 967 LKT 969
+K+
Sbjct: 320 VKS 322
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 2/154 (1%)
Query: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTA-YRDFCLAFIGKK 703
+ +LK L + + L D R+LC+ + C L+ + +K+ + A F +
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
L L ++ + E + LC L L+ L L + + L AN SL
Sbjct: 342 FLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797
+ L LS N L D G + L +++ +P L+ L L
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 144 bits (364), Expect = 3e-34
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 3/346 (0%)
Query: 649 LKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLTH 707
L+ L + + L D+ +++LC+ + C L+K++++ + A + + + K
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 708 LTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLR 767
LT++ + + + +LC L++ C L+ L+L T + + ++ + SL+ L
Sbjct: 175 LTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELA 233
Query: 768 LSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAK 827
L +N L D G L + P L+ L + C +T C DL VL + L L LA
Sbjct: 234 LGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAG 293
Query: 828 NPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI 887
N +GD G + LCE L P C+L++L ++ CS T C + S L + L L +S N++
Sbjct: 294 NELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRL 353
Query: 888 A-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKS 946
G+ LCQ L P L+ L L C + C L + LL+N L LDL N L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 947 GIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 121 bits (303), Expect = 4e-27
Identities = 88/267 (32%), Positives = 134/267 (50%), Gaps = 5/267 (1%)
Query: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLAFIGKKTL 705
+ K L V + ++++ VR+LC + S C L+ K+E VT D RD C K +L
Sbjct: 171 DFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGIVASKASL 229
Query: 706 THLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKH 765
L L G + M LC L + L+ L + T + + VL+A +SLK
Sbjct: 230 RELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825
L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++ L L +
Sbjct: 289 LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQI 348
Query: 826 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 885
+ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL LDLS N
Sbjct: 349 SNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNN 408
Query: 886 QIA-RGLWILCQALENPNCNLKHLRLW 911
+ G+ L +++ P C L+ L L+
Sbjct: 409 CLGDAGILQLVESVRQPGCLLEQLVLY 435
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 900 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 959
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 960 GSLKIL 965
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 2e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 728 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 787
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 788 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 847
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 848 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 906
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 907 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 966
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 967 LKT 969
+K+
Sbjct: 320 VKS 322
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 2/154 (1%)
Query: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTA-YRDFCLAFIGKK 703
+ +LK L + + L D R+LC+ + C L+ + +K+ + A F +
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
L L ++ + E + LC L L+ L L + + L AN SL
Sbjct: 342 FLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797
+ L LS N L D G + L +++ +P L+ L L
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 144 bits (364), Expect = 3e-34
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 3/346 (0%)
Query: 649 LKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLTH 707
L+ L + + L D+ +++LC+ + C L+K++++ + A + + + K
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 708 LTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLR 767
LT++ + + + +LC L++ C L+ L+L T + + ++ + SL+ L
Sbjct: 175 LTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELA 233
Query: 768 LSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAK 827
L +N L D G L + P L+ L + C +T C DL VL + L L LA
Sbjct: 234 LGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAG 293
Query: 828 NPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI 887
N +GD G + LCE L P C+L++L ++ CS T C + S L + L L +S N++
Sbjct: 294 NELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRL 353
Query: 888 A-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKS 946
G+ LCQ L P L+ L L C + C L + LL+N L LDL N L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 947 GIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 121 bits (303), Expect = 4e-27
Identities = 88/267 (32%), Positives = 134/267 (50%), Gaps = 5/267 (1%)
Query: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLAFIGKKTL 705
+ K L V + ++++ VR+LC + S C L+ K+E VT D RD C K +L
Sbjct: 171 DFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGIVASKASL 229
Query: 706 THLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKH 765
L L G + M LC L + L+ L + T + + VL+A +SLK
Sbjct: 230 RELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825
L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++ L L +
Sbjct: 289 LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQI 348
Query: 826 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 885
+ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL LDLS N
Sbjct: 349 SNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNN 408
Query: 886 QIA-RGLWILCQALENPNCNLKHLRLW 911
+ G+ L +++ P C L+ L L+
Sbjct: 409 CLGDAGILQLVESVRQPGCLLEQLVLY 435
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 900 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 959
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 960 GSLKIL 965
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 2e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 728 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 787
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 788 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 847
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 848 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 906
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 907 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 966
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 967 LKT 969
+K+
Sbjct: 320 VKS 322
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 2/154 (1%)
Query: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTA-YRDFCLAFIGKK 703
+ +LK L + + L D R+LC+ + C L+ + +K+ + A F +
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
L L ++ + E + LC L L+ L L + + L AN SL
Sbjct: 342 FLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797
+ L LS N L D G + L +++ +P L+ L L
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 144 bits (364), Expect = 3e-34
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 3/346 (0%)
Query: 649 LKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLTH 707
L+ L + + L D+ +++LC+ + C L+K++++ + A + + + K
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 708 LTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLR 767
LT++ + + + +LC L++ C L+ L+L T + + ++ + SL+ L
Sbjct: 175 LTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELA 233
Query: 768 LSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAK 827
L +N L D G L + P L+ L + C +T C DL VL + L L LA
Sbjct: 234 LGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAG 293
Query: 828 NPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI 887
N +GD G + LCE L P C+L++L ++ CS T C + S L + L L +S N++
Sbjct: 294 NELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRL 353
Query: 888 A-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKS 946
G+ LCQ L P L+ L L C + C L + LL+N L LDL N L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 947 GIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 121 bits (303), Expect = 4e-27
Identities = 88/267 (32%), Positives = 134/267 (50%), Gaps = 5/267 (1%)
Query: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLAFIGKKTL 705
+ K L V + ++++ VR+LC + S C L+ K+E VT D RD C K +L
Sbjct: 171 DFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGIVASKASL 229
Query: 706 THLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKH 765
L L G + M LC L + L+ L + T + + VL+A +SLK
Sbjct: 230 RELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825
L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++ L L +
Sbjct: 289 LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQI 348
Query: 826 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 885
+ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL LDLS N
Sbjct: 349 SNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNN 408
Query: 886 QIA-RGLWILCQALENPNCNLKHLRLW 911
+ G+ L +++ P C L+ L L+
Sbjct: 409 CLGDAGILQLVESVRQPGCLLEQLVLY 435
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 900 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 959
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 960 GSLKIL 965
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 2e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 728 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 787
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 788 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 847
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 848 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 906
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 907 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 966
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 967 LKT 969
+K+
Sbjct: 320 VKS 322
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 2/154 (1%)
Query: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTA-YRDFCLAFIGKK 703
+ +LK L + + L D R+LC+ + C L+ + +K+ + A F +
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
L L ++ + E + LC L L+ L L + + L AN SL
Sbjct: 342 FLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797
+ L LS N L D G + L +++ +P L+ L L
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 144 bits (364), Expect = 3e-34
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 3/346 (0%)
Query: 649 LKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLTH 707
L+ L + + L D+ +++LC+ + C L+K++++ + A + + + K
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
Query: 708 LTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLR 767
LT++ + + + +LC L++ C L+ L+L T + + ++ + SL+ L
Sbjct: 175 LTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELA 233
Query: 768 LSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAK 827
L +N L D G L + P L+ L + C +T C DL VL + L L LA
Sbjct: 234 LGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAG 293
Query: 828 NPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI 887
N +GD G + LCE L P C+L++L ++ CS T C + S L + L L +S N++
Sbjct: 294 NELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRL 353
Query: 888 A-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKS 946
G+ LCQ L P L+ L L C + C L + LL+N L LDL N L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 947 GIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 121 bits (303), Expect = 4e-27
Identities = 88/267 (32%), Positives = 134/267 (50%), Gaps = 5/267 (1%)
Query: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLAFIGKKTL 705
+ K L V + ++++ VR+LC + S C L+ K+E VT D RD C K +L
Sbjct: 171 DFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGIVASKASL 229
Query: 706 THLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKH 765
L L G + M LC L + L+ L + T + + VL+A +SLK
Sbjct: 230 RELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825
L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++ L L +
Sbjct: 289 LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQI 348
Query: 826 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 885
+ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL LDLS N
Sbjct: 349 SNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNN 408
Query: 886 QIA-RGLWILCQALENPNCNLKHLRLW 911
+ G+ L +++ P C L+ L L+
Sbjct: 409 CLGDAGILQLVESVRQPGCLLEQLVLY 435
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 900 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 959
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 960 GSLKIL 965
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 2e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 728 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 787
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 788 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 847
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 848 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 906
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 907 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 966
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 967 LKT 969
+K+
Sbjct: 320 VKS 322
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 2/154 (1%)
Query: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTA-YRDFCLAFIGKK 703
+ +LK L + + L D R+LC+ + C L+ + +K+ + A F +
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
L L ++ + E + LC L L+ L L + + L AN SL
Sbjct: 342 FLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797
+ L LS N L D G + L +++ +P L+ L L
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,724,878
Number of Sequences: 37866
Number of extensions: 1725710
Number of successful extensions: 5433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 4622
Number of HSP's gapped (non-prelim): 269
length of query: 1009
length of database: 18,247,518
effective HSP length: 112
effective length of query: 897
effective length of database: 14,006,526
effective search space: 12563853822
effective search space used: 12563853822
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.