Guide to the Human Genome
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Search of human proteins with 45827729

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45827729 scribble isoform b [Homo sapiens]
         (1630 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45827729 scribble isoform b [Homo sapiens]                        3224   0.0  
gi|45827731 scribble isoform a [Homo sapiens]                        3211   0.0  
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]           640   0.0  
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]        389   e-107
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]         389   e-107
gi|16904383 leucine rich repeat containing 7 [Homo sapiens]           387   e-107
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]          193   1e-48
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]          164   6e-40
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]          164   6e-40
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...   161   5e-39
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...   161   5e-39
gi|238908508 leucine-rich repeat and death domain-containing pro...   156   2e-37
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom...   155   3e-37
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                     152   3e-36
gi|148746189 multiple PDZ domain protein [Homo sapiens]               150   1e-35
gi|112382257 InaD-like [Homo sapiens]                                 149   2e-35
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...   148   5e-35
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...   147   8e-35
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                     145   3e-34
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                      145   3e-34
gi|21361633 leucine rich repeat containing 40 [Homo sapiens]          138   5e-32
gi|4503743 flightless I homolog [Homo sapiens]                        126   2e-28
gi|62241040 leucine rich repeat containing 8 family, member A [H...   121   5e-27
gi|187829877 leucine rich repeat containing 8 family, member A [...   121   5e-27
gi|187829871 leucine rich repeat containing 8 family, member A [...   121   5e-27
gi|197333692 leucine rich repeat containing 8 family, member B [...   119   2e-26
gi|21245134 leucine rich repeat containing 8 family, member B [H...   119   2e-26
gi|193788651 leucine rich repeat containing 69 [Homo sapiens]         117   1e-25
gi|61742786 leucine rich repeat and death domain containing prot...   116   2e-25
gi|61742784 leucine rich repeat and death domain containing prot...   116   2e-25

>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 3224 bits (8360), Expect = 0.0
 Identities = 1630/1630 (100%), Positives = 1630/1630 (100%)

Query: 1    MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
            MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN
Sbjct: 1    MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60

Query: 61   LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
            LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL
Sbjct: 61   LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120

Query: 121  PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
            PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD
Sbjct: 121  PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180

Query: 181  LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
            LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG
Sbjct: 181  LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240

Query: 241  GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
            GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL
Sbjct: 241  GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300

Query: 301  LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
            LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL
Sbjct: 301  LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360

Query: 361  HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
            HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP
Sbjct: 361  HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420

Query: 421  PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE 480
            PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE
Sbjct: 421  PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE 480

Query: 481  LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS 540
            LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS
Sbjct: 481  LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS 540

Query: 541  AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ 600
            AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ
Sbjct: 541  AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ 600

Query: 601  RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE 660
            RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE
Sbjct: 601  RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE 660

Query: 661  EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
            EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA
Sbjct: 661  EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720

Query: 721  RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
            RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL
Sbjct: 721  RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780

Query: 781  LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
            LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR
Sbjct: 781  LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840

Query: 841  GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
            GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG
Sbjct: 841  GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900

Query: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960
            GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP
Sbjct: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960

Query: 961  HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG 1020
            HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG
Sbjct: 961  HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG 1020

Query: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080
            GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR
Sbjct: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080

Query: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140
            PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS
Sbjct: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140

Query: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL 1200
            PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL
Sbjct: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL 1200

Query: 1201 EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG 1260
            EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG
Sbjct: 1201 EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG 1260

Query: 1261 LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA 1320
            LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA
Sbjct: 1261 LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA 1320

Query: 1321 YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV 1380
            YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV
Sbjct: 1321 YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV 1380

Query: 1381 GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP 1440
            GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP
Sbjct: 1381 GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP 1440

Query: 1441 TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL 1500
            TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL
Sbjct: 1441 TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL 1500

Query: 1501 WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST 1560
            WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST
Sbjct: 1501 WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST 1560

Query: 1561 SPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRP 1620
            SPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRP
Sbjct: 1561 SPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRP 1620

Query: 1621 GRRGLGPVPS 1630
            GRRGLGPVPS
Sbjct: 1621 GRRGLGPVPS 1630


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 3211 bits (8324), Expect = 0.0
 Identities = 1630/1655 (98%), Positives = 1630/1655 (98%), Gaps = 25/1655 (1%)

Query: 1    MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
            MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN
Sbjct: 1    MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60

Query: 61   LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
            LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL
Sbjct: 61   LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120

Query: 121  PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
            PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD
Sbjct: 121  PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180

Query: 181  LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
            LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG
Sbjct: 181  LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240

Query: 241  GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
            GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL
Sbjct: 241  GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300

Query: 301  LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
            LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL
Sbjct: 301  LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360

Query: 361  HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
            HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP
Sbjct: 361  HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420

Query: 421  PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE 480
            PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE
Sbjct: 421  PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE 480

Query: 481  LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS 540
            LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS
Sbjct: 481  LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS 540

Query: 541  AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ 600
            AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ
Sbjct: 541  AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ 600

Query: 601  RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE 660
            RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE
Sbjct: 601  RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE 660

Query: 661  EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
            EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA
Sbjct: 661  EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720

Query: 721  RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
            RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL
Sbjct: 721  RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780

Query: 781  LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
            LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR
Sbjct: 781  LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840

Query: 841  GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
            GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG
Sbjct: 841  GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900

Query: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960
            GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP
Sbjct: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960

Query: 961  HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG 1020
            HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG
Sbjct: 961  HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG 1020

Query: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080
            GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR
Sbjct: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080

Query: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140
            PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS
Sbjct: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140

Query: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL 1200
            PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL
Sbjct: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL 1200

Query: 1201 EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG 1260
            EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG
Sbjct: 1201 EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG 1260

Query: 1261 LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA 1320
            LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA
Sbjct: 1261 LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA 1320

Query: 1321 YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV 1380
            YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV
Sbjct: 1321 YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV 1380

Query: 1381 GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP 1440
            GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP
Sbjct: 1381 GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP 1440

Query: 1441 TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL 1500
            TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL
Sbjct: 1441 TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL 1500

Query: 1501 WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST 1560
            WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST
Sbjct: 1501 WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST 1560

Query: 1561 SPGRL-------------------------SPDFAEELRSLEPSPSPGPQEEDGEVALVL 1595
            SPGRL                         SPDFAEELRSLEPSPSPGPQEEDGEVALVL
Sbjct: 1561 SPGRLPLSGKKFDYRAFAALPSSRPVYDIQSPDFAEELRSLEPSPSPGPQEEDGEVALVL 1620

Query: 1596 LGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS 1630
            LGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS
Sbjct: 1621 LGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS 1655


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score =  640 bits (1652), Expect = 0.0
 Identities = 322/504 (63%), Positives = 404/504 (80%), Gaps = 15/504 (2%)

Query: 1   MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
           M  CIPLWRCNRHVES+DKRHCSL  VPEEIYRY+RSLEELLLDANQLRELP+ FF+L+ 
Sbjct: 1   MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60

Query: 61  LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
           LRKLGLSDNEIQRLPPE+ANFMQLVELDVSRN+IPEIPESI FCKAL++ADFSGNPL+RL
Sbjct: 61  LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120

Query: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
           P+ F +L++L  L++ND+SLQ+LP ++GNL NL +LELRENLL  LP SL+ L +LE+LD
Sbjct: 121 PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180

Query: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
           LG N++  LP+++GAL +L++LWLD NQLS LP E+GNL+ L+CLDVSENRLE LP E+ 
Sbjct: 181 LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS 240

Query: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
           GL  LTDL++SQNLL  +PDGIG+LK+LSILKVDQNRL ++ EA+G+CE+L+EL+LTEN 
Sbjct: 241 GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ 300

Query: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
           L+ LP+S+GKL KL+NLN DRN L +LP EIGGC +L+V  +RDNRL  +P E++  TEL
Sbjct: 301 LLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360

Query: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
           HVLDVAGNRL  LP +LT L LKALWL++NQ+QP+L FQT+ D  TGEK+LTC LLPQ P
Sbjct: 361 HVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLP 420

Query: 421 --PLSLEDAGQQGSL--------SETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGL 470
             P   E+  + G+L         E W++   +RVS I+F+E     ++ +E   E R L
Sbjct: 421 SEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVE-----DEKDEEDNETRTL 475

Query: 471 QRRATPHPSELKVMKRSIEGRRSE 494
            RRATPHP ELK MK+++E  R++
Sbjct: 476 LRRATPHPGELKHMKKTVENLRND 499


>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
          Length = 1302

 Score =  389 bits (998), Expect = e-107
 Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%)

Query: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
           V ++D  HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK  F   +L KL L DN++  
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83

Query: 74  LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
           LP  +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L  L
Sbjct: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143

Query: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
            LND  L+ LP + G L  L  LELREN LK LP +++ L +LE+LDLG N+   +P+ L
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203

Query: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
             L  L+E W+D N+L+ +P  +G+L++L  LDVS+N +E +   +     L DLLLS N
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            L++LP+ IG LK ++ LK+D+N+L  + ++IG   ++ EL  + N + ALP S+G+LT 
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
           L     D N+L+ LPPEIG    ++VL L  N+L  LP E+    +L V++++ NRL++L
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383

Query: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428
           PF+ T L  L A+WL++NQ++P++  Q E D+ T + VLT Y+ PQQP    ED    + 
Sbjct: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441

Query: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488
            +      W +    R  V    +    D+D  EA   +  L+R  TP+P ELK M +++
Sbjct: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498

Query: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543
           +    R +      DSG  L P E+++ ++ + G+  SE +    S V E E        
Sbjct: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558

Query: 544 QGGSQQEATTAGG 556
           Q  S+ EA  + G
Sbjct: 559 QKISEPEAEISPG 571



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 50/188 (26%), Positives = 89/188 (47%), Gaps = 12/188 (6%)

Query: 632  MQPDGEGPVAPGGWH-NGPHAPWAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTE 690
            M P  + P++   +  +GP+A    R Q       E   +     +   +R    +    
Sbjct: 1119 MMPGSQRPLSARTYSIDGPNAS---RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNA 1175

Query: 691  EEDKEGAVVSAPSVKGVSFDQANNLL--IEPARIEEEELTLTILRQTGGLGISIAGGKGS 748
                E +++  P    V  D    +L  IE  ++E+  + +    +   LG SI+GG G 
Sbjct: 1176 RVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKIRVRV---EKDPELGFSISGGVGG 1232

Query: 749  --TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTA 806
               P++ DD+GIF++RV  EGPA++  ++ GDK+++ NG +    EH +AV  L+     
Sbjct: 1233 RGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNT 1291

Query: 807  VQMRVWRE 814
            V++ + RE
Sbjct: 1292 VELIIVRE 1299



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 32/86 (37%), Positives = 54/86 (62%), Gaps = 5/86 (5%)

Query: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162
            ++K P   LG SI GG  G  GNP  P D+GIF+++V P G A +   L+ G ++++ N 
Sbjct: 1216 VEKDP--ELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANG 1270

Query: 1163 QSLLGLTHGEAVQLLRSVGDTLTVLV 1188
             S + + HG+AV LL++  +T+ +++
Sbjct: 1271 YSFINIEHGQAVSLLKTFQNTVELII 1296



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 34/80 (42%), Positives = 45/80 (56%), Gaps = 4/80 (5%)

Query: 872  LGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD 929
            LGFSI+GG G    P+R  D GIFV+R+   G A +   LQ GD+++  NG       H 
Sbjct: 1222 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANGYSFINIEHG 1279

Query: 930  HAVSLLTAASPTIALLLERE 949
             AVSLL     T+ L++ RE
Sbjct: 1280 QAVSLLKTFQNTVELIIVRE 1299



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 37/118 (31%), Positives = 57/118 (48%), Gaps = 3/118 (2%)

Query: 962  SSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGP-LGLSIVG 1020
            S  P A V +       PG   +P      +   +E    +E+IR+     P LG SI G
Sbjct: 1170 SKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAK-KLEKIRVRVEKDPELGFSISG 1228

Query: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL 1078
            G     +PF   + G+F+++V P G A++  L+ GD+I+  NG    +  H +AVS L
Sbjct: 1229 GVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAVSLL 1285


>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
          Length = 1371

 Score =  389 bits (998), Expect = e-107
 Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%)

Query: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
           V ++D  HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK  F   +L KL L DN++  
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83

Query: 74  LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
           LP  +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L  L
Sbjct: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143

Query: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
            LND  L+ LP + G L  L  LELREN LK LP +++ L +LE+LDLG N+   +P+ L
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203

Query: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
             L  L+E W+D N+L+ +P  +G+L++L  LDVS+N +E +   +     L DLLLS N
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            L++LP+ IG LK ++ LK+D+N+L  + ++IG   ++ EL  + N + ALP S+G+LT 
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
           L     D N+L+ LPPEIG    ++VL L  N+L  LP E+    +L V++++ NRL++L
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383

Query: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428
           PF+ T L  L A+WL++NQ++P++  Q E D+ T + VLT Y+ PQQP    ED    + 
Sbjct: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441

Query: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488
            +      W +    R  V    +    D+D  EA   +  L+R  TP+P ELK M +++
Sbjct: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498

Query: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543
           +    R +      DSG  L P E+++ ++ + G+  SE +    S V E E        
Sbjct: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558

Query: 544 QGGSQQEATTAGG 556
           Q  S+ EA  + G
Sbjct: 559 QKISEPEAEISPG 571



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 32/79 (40%), Positives = 51/79 (64%), Gaps = 3/79 (3%)

Query: 738  LGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHE 795
            LG SI+GG G    P++ DD+GIF++RV  EGPA++  ++ GDK+++ NG +    EH +
Sbjct: 1291 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQ 1349

Query: 796  AVEALRGAGTAVQMRVWRE 814
            AV  L+     V++ + RE
Sbjct: 1350 AVSLLKTFQNTVELIIVRE 1368



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 4/105 (3%)

Query: 847  PLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAH 904
            P   P     L ++ +      +  LGFSI+GG G    P+R  D GIFV+R+   G A 
Sbjct: 1266 PHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPAS 1325

Query: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE 949
            +   LQ GD+++  NG       H  AVSLL     T+ L++ RE
Sbjct: 1326 KL--LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVRE 1368



 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 31/90 (34%), Positives = 55/90 (61%), Gaps = 3/90 (3%)

Query: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
            +E+ ++      LG SI GG  G  GNP  P D+GIF+++V P G A +   L+ G +++
Sbjct: 1279 QEIRVRVEKDPELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKII 1335

Query: 1159 EVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
            + N  S + + HG+AV LL++  +T+ +++
Sbjct: 1336 QANGYSFINIEHGQAVSLLKTFQNTVELII 1365



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 29/77 (37%), Positives = 44/77 (57%), Gaps = 2/77 (2%)

Query: 1003 EEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAV 1061
            +EIR+     P LG SI GG     +PF   + G+F+++V P G A++  L+ GD+I+  
Sbjct: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQA 1337

Query: 1062 NGQDVRDATHQEAVSAL 1078
            NG    +  H +AVS L
Sbjct: 1338 NGYSFINIEHGQAVSLL 1354


>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
          Length = 1537

 Score =  387 bits (994), Expect = e-107
 Identities = 219/486 (45%), Positives = 302/486 (62%), Gaps = 14/486 (2%)

Query: 9   RCNRHVESV----DKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64
           RC R  E +    D  HCSLQ VP+E++ + R+LEEL LDANQ+ ELPK  F    LRKL
Sbjct: 15  RCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKL 74

Query: 65  GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGF 124
            + DN++  LP  +A+ + L ELD+S+N + E PE+IK CK L I + S NP+S+LPDGF
Sbjct: 75  SIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGF 134

Query: 125 TQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN 184
           TQL +L  L LND  L+ LP + G L  L  LELREN LK+LP S+  L +LE+LDLG N
Sbjct: 135 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194

Query: 185 DLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVL 244
           +   LP+ L  + NLRELW+D N L  LP  +G L+ LV LD+S+NR+E +  ++ G   
Sbjct: 195 EFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254

Query: 245 LTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMAL 304
           L DLLLS N+L++LPD IG LK+L+ LKVD N+L  +   IG+   L E   + N L +L
Sbjct: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314

Query: 305 PRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLD 364
           P ++G L  L  L VD N L  LP EIG C  ++V+SLR N+L  LP E+    +L VL+
Sbjct: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374

Query: 365 VAGNRLQSLPFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLS 423
           ++ NRL++LPF+ T L  L ALWL++NQ++ ++  QTE    T ++VLT Y+ PQQP   
Sbjct: 375 LSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGD 434

Query: 424 LEDAGQQGSLSET-WSDAPPSRVSV-IQFLEAPIGDEDAEEA------AAEKRGLQRRAT 475
            +      S + T W +    R++V  +F +    DE+A +       A  +RG QR  T
Sbjct: 435 EDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERG-QRGIT 493

Query: 476 PHPSEL 481
             P+ L
Sbjct: 494 LQPARL 499



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 35/86 (40%), Positives = 54/86 (62%), Gaps = 5/86 (5%)

Query: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162
            I+K PG  LG SI GG  G  GNP  P+D+GIF+++V P G A     L+ G ++L+ N 
Sbjct: 1451 IEKNPG--LGFSISGGISGQ-GNPFKPSDKGIFVTRVQPDGPA--SNLLQPGDKILQANG 1505

Query: 1163 QSLLGLTHGEAVQLLRSVGDTLTVLV 1188
             S + + H +AV LL+S  +T+ +++
Sbjct: 1506 HSFVHMEHEKAVLLLKSFQNTVDLVI 1531



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 33/81 (40%), Positives = 47/81 (58%), Gaps = 4/81 (4%)

Query: 871  GLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARH 928
            GLGFSI+GG      P++  D GIFV+R+   G A  +  LQ GD++L  NG       H
Sbjct: 1456 GLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPA--SNLLQPGDKILQANGHSFVHMEH 1513

Query: 929  DHAVSLLTAASPTIALLLERE 949
            + AV LL +   T+ L+++RE
Sbjct: 1514 EKAVLLLKSFQNTVDLVIQRE 1534



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 33/88 (37%), Positives = 51/88 (57%), Gaps = 3/88 (3%)

Query: 732  LRQTGGLGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQ 789
            + +  GLG SI+GG      P+K  D+GIF++RV  +GPA+   ++ GDK+L+ NG +  
Sbjct: 1451 IEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNL-LQPGDKILQANGHSFV 1509

Query: 790  GAEHHEAVEALRGAGTAVQMRVWRERMV 817
              EH +AV  L+     V + + RE  V
Sbjct: 1510 HMEHEKAVLLLKSFQNTVDLVIQRELTV 1537



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 2/88 (2%)

Query: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQ 1064
            +R+ +  G LG SI GG     +PF   + G+F+++V P G A+   L+ GD+IL  NG 
Sbjct: 1449 VRIEKNPG-LGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNL-LQPGDKILQANGH 1506

Query: 1065 DVRDATHQEAVSALLRPCLELSLLVRRD 1092
                  H++AV  L      + L+++R+
Sbjct: 1507 SFVHMEHEKAVLLLKSFQNTVDLVIQRE 1534


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score =  193 bits (490), Expect = 1e-48
 Identities = 131/390 (33%), Positives = 200/390 (51%), Gaps = 28/390 (7%)

Query: 12  RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEI 71
           + +  +D RH  L+ +P  +YR   SL  L L  N++  + K    L  L  L + +N+I
Sbjct: 169 KKLRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227

Query: 72  QRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLA 131
           ++LP E+     L+ LDV+ N +  +P+ I  C  +   D   N L  LPD    L SL+
Sbjct: 228 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287

Query: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL-SFLVKLEQLDLGGNDLEVLP 190
            L L    L A+P  +   + L  L L  N + +LP SL S LVKL  L L  N  ++ P
Sbjct: 288 RLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347

Query: 191 -----------------DTLGALPN--------LRELWLDRNQLSALPPELGNLRRLVCL 225
                            + +  +P         L +L +  NQL++LP + G    +V L
Sbjct: 348 VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVEL 407

Query: 226 DVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAI 285
           +++ N+L ++P ++ GLV L  L+LS NLL++LP G+G L++L  L +++N+L  +   I
Sbjct: 408 NLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI 467

Query: 286 GDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDN 345
              ++L +L+LT N L  LPR +G LT LT+L +  N L  LP EIG    L  L L DN
Sbjct: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527

Query: 346 -RLAVLPPELAHTTELHVLDVAGNRLQSLP 374
             L  LP ELA  ++L ++ +    L  LP
Sbjct: 528 PNLHSLPFELALCSKLSIMSIENCPLSHLP 557



 Score =  183 bits (464), Expect = 1e-45
 Identities = 124/379 (32%), Positives = 197/379 (51%), Gaps = 5/379 (1%)

Query: 23  SLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82
           S+  +P  I   ++ L EL L +N+L+ LP     L+NL  L LS+N +  LP  + N  
Sbjct: 111 SIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLK 169

Query: 83  QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142
           +L  LD+  N + EIP  +    +L       N ++ +      L  L+ L++ +  ++ 
Sbjct: 170 KLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229

Query: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
           LP ++G L NL+TL++  N L+ LP  +    ++  LDL  N+L  LPDT+G L +L  L
Sbjct: 230 LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRL 289

Query: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGGLVLLTDLLLSQNLLRRLP-D 260
            L  N+LSA+P  L     L  L++  N +  LP   L  LV L  L L++N  +  P  
Sbjct: 290 GLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349

Query: 261 GIGQLKQLSILKVDQNRLCEVTEAI-GDCENLSELILTENLLMALPRSLGKLTKLTNLNV 319
           G  Q   +  L ++ NR+ ++   I    + LS+L + +N L +LP   G  T +  LN+
Sbjct: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409

Query: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTH 379
             N L  +P ++ G V+L VL L +N L  LP  L +  +L  LD+  N+L+SLP  + +
Sbjct: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469

Query: 380 L-NLKALWLAENQAQPMLR 397
           L +L+ L L  NQ   + R
Sbjct: 470 LKDLQKLVLTNNQLTTLPR 488



 Score =  157 bits (397), Expect = 8e-38
 Identities = 101/282 (35%), Positives = 153/282 (54%), Gaps = 9/282 (3%)

Query: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
           D S   +  LP    +L  L  L L    LQ+LP +VG L NL+TL L EN L SLP SL
Sbjct: 106 DLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSL 165

Query: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
             L KL  LDL  N L  +P  +  L +L  L+L  N+++ +  ++ NL +L  L + EN
Sbjct: 166 DNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIREN 225

Query: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCEN 290
           ++++LPAE+G L  L  L ++ N L  LP  IG   Q++ L +  N L ++ + IG+  +
Sbjct: 226 KIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSS 285

Query: 291 LSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPE-IGGCVALSVLSLRDNRLAV 349
           LS L L  N L A+PRSL K + L  LN++ N++  LP   +   V L+ L+L  N   +
Sbjct: 286 LSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQL 345

Query: 350 LP-PELAHTTELHVLDVAGNRLQSLPF-------ALTHLNLK 383
            P    +  + ++ L++  NR+  +PF        L+ LN+K
Sbjct: 346 YPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMK 387



 Score =  141 bits (356), Expect = 5e-33
 Identities = 88/241 (36%), Positives = 137/241 (56%), Gaps = 2/241 (0%)

Query: 152 NLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSA 211
           N + L+L +  +  LP+S+  L +L +L L  N L+ LP  +G L NL  L L  N L++
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160

Query: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSIL 271
           LP  L NL++L  LD+  N+L E+P+ +  L  LT L L  N +  +   I  L +LS+L
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220

Query: 272 KVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
            + +N++ ++   IG+  NL  L +  N L  LP+ +G  T++TNL++  N L  LP  I
Sbjct: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280

Query: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFAL--THLNLKALWLAE 389
           G   +LS L LR NRL+ +P  LA  + L  L++  N + +LP +L  + + L +L LA 
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340

Query: 390 N 390
           N
Sbjct: 341 N 341


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score =  164 bits (415), Expect = 6e-40
 Identities = 136/408 (33%), Positives = 196/408 (48%), Gaps = 60/408 (14%)

Query: 720  ARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGD 778
            A  E EE+TL   R   GLG SIAGG  + P+ GDD  IFI+++   G AA+ G +RV D
Sbjct: 218  ADYEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVND 274

Query: 779  KLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
             +L VN V ++   H +AVEAL+ AG+ V++ V R + V  E  + I             
Sbjct: 275  CILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS-EKIMEIK------------ 321

Query: 839  RRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIA 898
                                      L +  +GLGFSIAGG G+  +  GD  I+V++I 
Sbjct: 322  --------------------------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKII 354

Query: 899  EGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG-----GP 953
            EGGAAH+ G LQ+GD++L++N V + E  H+ AV+ L   S  + L + +        G 
Sbjct: 355  EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGY 414

Query: 954  LPPSPLPHSSPPT-AAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGG 1012
             PP     SS P    V+ +S    TP  P   S     +    E      ++ L R   
Sbjct: 415  APPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST 474

Query: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
             LG +IVGG D           G+FIS +L  G A  SG LR GDRI++VN  D+R A+H
Sbjct: 475  GLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525

Query: 1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGA 1119
            ++A +AL      ++++ +  P      E  I     + +  SI  G+
Sbjct: 526  EQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGS 573



 Score =  126 bits (316), Expect = 2e-28
 Identities = 94/277 (33%), Positives = 138/277 (49%), Gaps = 15/277 (5%)

Query: 911  VGDRVLSINGVDVTEARHDHAV---SLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTA 967
            +G  ++ ++  +++E  + H     S ++   PT A+L        +P  P+P  +  T 
Sbjct: 130  IGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAEN--TV 187

Query: 968  AVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSH 1027
             + T       P +    SL         +  Y  EEI L R    LG SI GG+D+   
Sbjct: 188  ILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDN--- 244

Query: 1028 PFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELS 1086
            P    +  +FI+K++  G AA+ G LRV D IL VN  DVRD TH +AV AL      + 
Sbjct: 245  PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVR 304

Query: 1087 LLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAA 1145
            L V RR P    + E+ + K P + LG SI GG     GN   P D  I+++K+   GAA
Sbjct: 305  LYVKRRKPVSEKIMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDNSIYVTKIIEGGAA 359

Query: 1146 GRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
             +DG+L++G +LL VN   L  +TH EAV  L++  D
Sbjct: 360  HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSD 396



 Score =  112 bits (280), Expect = 3e-24
 Identities = 113/434 (26%), Positives = 177/434 (40%), Gaps = 102/434 (23%)

Query: 865  LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
            L R   GLGFSIAGG  + P+   D+ IF+++I  GGAA + G L+V D +L +N VDV 
Sbjct: 227  LERGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVR 285

Query: 925  EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
            +  H  AV  L  A   + L ++R         P+                         
Sbjct: 286  DVTHSKAVEALKEAGSIVRLYVKRR-------KPVSEK---------------------- 316

Query: 985  PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
                             + EI+L +    LG SI GG  +   P    +  ++++K++  
Sbjct: 317  -----------------IMEIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 356

Query: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL--------LRPCLELSLLVRRDPAP 1095
            G A + G L++GD++LAVN   + + TH+EAV+AL        L+     S+ +    AP
Sbjct: 357  GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416

Query: 1096 PGLRELCIQK-----APGERLGISIRGGAR---------GHAGNPRDPTD---------- 1131
            P +     Q      +P   LG +    AR         G     R+P            
Sbjct: 417  PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGL 476

Query: 1132 ----------EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
                      EGIFIS +   G A   G LR G R++ VN   L   +H +A   L++ G
Sbjct: 477  GFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536

Query: 1182 DTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEG 1235
              +T++          FEA      ++   ++ +  ++G G   + +  S   R L    
Sbjct: 537  QAVTIVAQYRPEEYSRFEAKIH---DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYD 593

Query: 1236 PGKEKELPGQTLHW 1249
              K+  LP Q L++
Sbjct: 594  KTKDSGLPSQGLNF 607


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score =  164 bits (415), Expect = 6e-40
 Identities = 136/408 (33%), Positives = 196/408 (48%), Gaps = 60/408 (14%)

Query: 720  ARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGD 778
            A  E EE+TL   R   GLG SIAGG  + P+ GDD  IFI+++   G AA+ G +RV D
Sbjct: 218  ADYEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVND 274

Query: 779  KLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
             +L VN V ++   H +AVEAL+ AG+ V++ V R + V  E  + I             
Sbjct: 275  CILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS-EKIMEIK------------ 321

Query: 839  RRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIA 898
                                      L +  +GLGFSIAGG G+  +  GD  I+V++I 
Sbjct: 322  --------------------------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKII 354

Query: 899  EGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG-----GP 953
            EGGAAH+ G LQ+GD++L++N V + E  H+ AV+ L   S  + L + +        G 
Sbjct: 355  EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGY 414

Query: 954  LPPSPLPHSSPPT-AAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGG 1012
             PP     SS P    V+ +S    TP  P   S     +    E      ++ L R   
Sbjct: 415  APPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST 474

Query: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
             LG +IVGG D           G+FIS +L  G A  SG LR GDRI++VN  D+R A+H
Sbjct: 475  GLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525

Query: 1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGA 1119
            ++A +AL      ++++ +  P      E  I     + +  SI  G+
Sbjct: 526  EQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGS 573



 Score =  126 bits (316), Expect = 2e-28
 Identities = 94/277 (33%), Positives = 138/277 (49%), Gaps = 15/277 (5%)

Query: 911  VGDRVLSINGVDVTEARHDHAV---SLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTA 967
            +G  ++ ++  +++E  + H     S ++   PT A+L        +P  P+P  +  T 
Sbjct: 130  IGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAEN--TV 187

Query: 968  AVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSH 1027
             + T       P +    SL         +  Y  EEI L R    LG SI GG+D+   
Sbjct: 188  ILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDN--- 244

Query: 1028 PFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELS 1086
            P    +  +FI+K++  G AA+ G LRV D IL VN  DVRD TH +AV AL      + 
Sbjct: 245  PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVR 304

Query: 1087 LLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAA 1145
            L V RR P    + E+ + K P + LG SI GG     GN   P D  I+++K+   GAA
Sbjct: 305  LYVKRRKPVSEKIMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDNSIYVTKIIEGGAA 359

Query: 1146 GRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
             +DG+L++G +LL VN   L  +TH EAV  L++  D
Sbjct: 360  HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSD 396



 Score =  112 bits (280), Expect = 3e-24
 Identities = 113/434 (26%), Positives = 177/434 (40%), Gaps = 102/434 (23%)

Query: 865  LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
            L R   GLGFSIAGG  + P+   D+ IF+++I  GGAA + G L+V D +L +N VDV 
Sbjct: 227  LERGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVR 285

Query: 925  EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
            +  H  AV  L  A   + L ++R         P+                         
Sbjct: 286  DVTHSKAVEALKEAGSIVRLYVKRR-------KPVSEK---------------------- 316

Query: 985  PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
                             + EI+L +    LG SI GG  +   P    +  ++++K++  
Sbjct: 317  -----------------IMEIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 356

Query: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL--------LRPCLELSLLVRRDPAP 1095
            G A + G L++GD++LAVN   + + TH+EAV+AL        L+     S+ +    AP
Sbjct: 357  GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416

Query: 1096 PGLRELCIQK-----APGERLGISIRGGAR---------GHAGNPRDPTD---------- 1131
            P +     Q      +P   LG +    AR         G     R+P            
Sbjct: 417  PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGL 476

Query: 1132 ----------EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
                      EGIFIS +   G A   G LR G R++ VN   L   +H +A   L++ G
Sbjct: 477  GFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536

Query: 1182 DTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEG 1235
              +T++          FEA      ++   ++ +  ++G G   + +  S   R L    
Sbjct: 537  QAVTIVAQYRPEEYSRFEAKIH---DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYD 593

Query: 1236 PGKEKELPGQTLHW 1249
              K+  LP Q L++
Sbjct: 594  KTKDSGLPSQGLNF 607


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens]
          Length = 767

 Score =  161 bits (407), Expect = 5e-39
 Identities = 135/420 (32%), Positives = 199/420 (47%), Gaps = 66/420 (15%)

Query: 722  IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
            +E EE+TL   R   GLG SIAGG  + P+ GDD  IFI+++   G AA+ G +RV D +
Sbjct: 104  MEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160

Query: 781  LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
            L VN V ++   H  AVEAL+ AG+ V++ V R +                         
Sbjct: 161  LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP------------------------ 196

Query: 841  GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
                     P E    ++      L +  +GLGFSIAGG G+  +  GD  I+V++I EG
Sbjct: 197  ---------PAEKVMEIK------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKIIEG 240

Query: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVS---------LLTAASPTIALLLEREAG 951
            GAAH+ G LQ+GD++L++N V + +  H+ AV+          L  A P+ A L +  A 
Sbjct: 241  GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300

Query: 952  GPLPPS---PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008
              +  S    L +    ++ + T   T  TP  P   S     L    + P     I + 
Sbjct: 301  PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360

Query: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
            R    LG +IVGG D           G+FIS +L  G A  SG LR GD+IL+VNG D+R
Sbjct: 361  RGSTGLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411

Query: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
            +A+H++A  AL      ++++ +  P      E  I     + +  S+  G      NP+
Sbjct: 412  NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 471



 Score =  121 bits (304), Expect = 5e-27
 Identities = 90/236 (38%), Positives = 120/236 (50%), Gaps = 18/236 (7%)

Query: 958  PLPHSS---PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPL 1014
            PL HS    P  A      + T T   PG       L     EG    EEI L R    L
Sbjct: 64   PLEHSPAHLPNQANSPPVIVNTDTLEAPGY-----ELQVNGTEGEMEYEEITLERGNSGL 118

Query: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
            G SI GG+D+   P    +P +FI+K++P G AA+ G LRV D IL VN  DVR+ TH  
Sbjct: 119  GFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175

Query: 1074 AVSALLRPCLELSLLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDE 1132
            AV AL      + L V RR P    + E+ + K P + LG SI GG     GN   P D 
Sbjct: 176  AVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDN 230

Query: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
             I+++K+   GAA +DGRL++G ++L VN   L  + H +AV  L++  D + + V
Sbjct: 231  SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286



 Score =  107 bits (266), Expect = 1e-22
 Identities = 103/372 (27%), Positives = 146/372 (39%), Gaps = 99/372 (26%)

Query: 865  LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
            L R   GLGFSIAGG  + P+   D  IF+++I  GGAA + G L+V D +L +N VDV 
Sbjct: 111  LERGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 169

Query: 925  EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
            E  H  AV  L  A   + L + R               PP   V               
Sbjct: 170  EVTHSAAVEALKEAGSIVRLYVMRR-------------KPPAEKVM-------------- 202

Query: 985  PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
                               EI+L +    LG SI GG  +   P    +  ++++K++  
Sbjct: 203  -------------------EIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 240

Query: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP--------AP 1095
            G A + G L++GD+ILAVN   + D  H++AV+AL      + L V +          AP
Sbjct: 241  GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300

Query: 1096 PGLRELCIQKAPGERLGISIRG--------------------GARGHAGNPRDPT----- 1130
            P +     Q    E    S  G                       G    PR+P      
Sbjct: 301  PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360

Query: 1131 ---------------DEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQ 1175
                            EGIFIS +   G A   G LR G ++L VN   L   +H +A  
Sbjct: 361  RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420

Query: 1176 LLRSVGDTLTVL 1187
             L++ G T+T++
Sbjct: 421  ALKNAGQTVTII 432



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 7/112 (6%)

Query: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
            LG SI GG      NP    D  IFI+K+ P GAA +DGRLRV   +L VN+  +  +TH
Sbjct: 118  LGFSIAGGT----DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 173

Query: 1171 GEAVQLLRSVGDTLTVLVC---DGFEASTDAALEVSPGVIANPFAAGIGHRN 1219
              AV+ L+  G  + + V       E   +  L   P  +    A G+G+++
Sbjct: 174  SAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQH 225


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
            sapiens]
          Length = 721

 Score =  161 bits (407), Expect = 5e-39
 Identities = 135/420 (32%), Positives = 199/420 (47%), Gaps = 66/420 (15%)

Query: 722  IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
            +E EE+TL   R   GLG SIAGG  + P+ GDD  IFI+++   G AA+ G +RV D +
Sbjct: 58   MEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 114

Query: 781  LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
            L VN V ++   H  AVEAL+ AG+ V++ V R +                         
Sbjct: 115  LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP------------------------ 150

Query: 841  GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
                     P E    ++      L +  +GLGFSIAGG G+  +  GD  I+V++I EG
Sbjct: 151  ---------PAEKVMEIK------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKIIEG 194

Query: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVS---------LLTAASPTIALLLEREAG 951
            GAAH+ G LQ+GD++L++N V + +  H+ AV+          L  A P+ A L +  A 
Sbjct: 195  GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254

Query: 952  GPLPPS---PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008
              +  S    L +    ++ + T   T  TP  P   S     L    + P     I + 
Sbjct: 255  PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314

Query: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
            R    LG +IVGG D           G+FIS +L  G A  SG LR GD+IL+VNG D+R
Sbjct: 315  RGSTGLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365

Query: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
            +A+H++A  AL      ++++ +  P      E  I     + +  S+  G      NP+
Sbjct: 366  NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 425



 Score =  120 bits (300), Expect = 1e-26
 Identities = 89/236 (37%), Positives = 120/236 (50%), Gaps = 21/236 (8%)

Query: 958  PLPHSS---PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPL 1014
            PL HS    P  A      + T T   PG  +          EG    EEI L R    L
Sbjct: 21   PLEHSPAHLPNQANSPPVIVNTDTLEAPGYVN--------GTEGEMEYEEITLERGNSGL 72

Query: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
            G SI GG+D+   P    +P +FI+K++P G AA+ G LRV D IL VN  DVR+ TH  
Sbjct: 73   GFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129

Query: 1074 AVSALLRPCLELSLLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDE 1132
            AV AL      + L V RR P    + E+ + K P + LG SI GG     GN   P D 
Sbjct: 130  AVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDN 184

Query: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
             I+++K+   GAA +DGRL++G ++L VN   L  + H +AV  L++  D + + V
Sbjct: 185  SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240



 Score =  107 bits (266), Expect = 1e-22
 Identities = 103/372 (27%), Positives = 146/372 (39%), Gaps = 99/372 (26%)

Query: 865  LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
            L R   GLGFSIAGG  + P+   D  IF+++I  GGAA + G L+V D +L +N VDV 
Sbjct: 65   LERGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 123

Query: 925  EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
            E  H  AV  L  A   + L + R               PP   V               
Sbjct: 124  EVTHSAAVEALKEAGSIVRLYVMRR-------------KPPAEKVM-------------- 156

Query: 985  PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
                               EI+L +    LG SI GG  +   P    +  ++++K++  
Sbjct: 157  -------------------EIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 194

Query: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP--------AP 1095
            G A + G L++GD+ILAVN   + D  H++AV+AL      + L V +          AP
Sbjct: 195  GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254

Query: 1096 PGLRELCIQKAPGERLGISIRG--------------------GARGHAGNPRDPT----- 1130
            P +     Q    E    S  G                       G    PR+P      
Sbjct: 255  PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314

Query: 1131 ---------------DEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQ 1175
                            EGIFIS +   G A   G LR G ++L VN   L   +H +A  
Sbjct: 315  RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374

Query: 1176 LLRSVGDTLTVL 1187
             L++ G T+T++
Sbjct: 375  ALKNAGQTVTII 386



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 7/112 (6%)

Query: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
            LG SI GG      NP    D  IFI+K+ P GAA +DGRLRV   +L VN+  +  +TH
Sbjct: 72   LGFSIAGGT----DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127

Query: 1171 GEAVQLLRSVGDTLTVLVC---DGFEASTDAALEVSPGVIANPFAAGIGHRN 1219
              AV+ L+  G  + + V       E   +  L   P  +    A G+G+++
Sbjct: 128  SAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQH 179


>gi|238908508 leucine-rich repeat and death domain-containing
           protein [Homo sapiens]
          Length = 860

 Score =  156 bits (394), Expect = 2e-37
 Identities = 108/380 (28%), Positives = 196/380 (51%), Gaps = 5/380 (1%)

Query: 16  SVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLP 75
           S+D     + ++P+EI R  ++LE LL+D N+L  L    F+LL +++L L+DN+++ + 
Sbjct: 307 SLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365

Query: 76  PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL 135
            ++ NF +L  L + +N +  IPE I  C  LE    S N L+ LP    +L +L  L +
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425

Query: 136 NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195
           N  ++  +   + +L N+ +LE   N++  +P  +    K+ +++L  N +   P  L A
Sbjct: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485

Query: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255
           L +L  L ++ N +S +P ++   ++L+ L++SEN+L         L+ L  L L +N +
Sbjct: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQI 545

Query: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315
           +++P  I  +  L +L +  N+       +   ENL  L L+EN L  +   +  L  + 
Sbjct: 546 KKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQ 605

Query: 316 NLNVDRNHLEALPPE---IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQS 372
            LN   N     P E   +     L++  ++  +L  LP EL++ T+L  LD++ N ++ 
Sbjct: 606 KLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE 665

Query: 373 LPFALTHL-NLKALWLAENQ 391
           +P  +  L NL +L    NQ
Sbjct: 666 IPRNIGELRNLVSLHAYNNQ 685



 Score =  155 bits (393), Expect = 2e-37
 Identities = 108/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           L+ +PE+I      LE L L  N+L ELPK   +L NLRKL ++ N + ++   +++   
Sbjct: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442

Query: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143
           +  L+ S N I ++P  IK C+ +   + S N +   P G   L SL +L++N   +  +
Sbjct: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502

Query: 144 PGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELW 203
           P D+     L+ LEL EN L         L+ L+ LDLG N ++ +P ++  + +L  L 
Sbjct: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562

Query: 204 LDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIG 263
           L  N+    P EL  L  L  LD+SEN+L+++ +++  L  +  L  S N     P  + 
Sbjct: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622

Query: 264 QLKQLSILKVDQNRLCEVTEAIGDCEN---LSELILTENLLMALPRSLGKLTKLTNLNVD 320
           QL+ L  L + Q +  ++T   G+  N   L EL ++ N +  +PR++G+L  L +L+  
Sbjct: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682

Query: 321 RNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
            N +  LPP +     L  L+L  N L  LP  + +   L  ++   N L   P
Sbjct: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736



 Score =  154 bits (388), Expect = 9e-37
 Identities = 112/404 (27%), Positives = 194/404 (48%), Gaps = 25/404 (6%)

Query: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
           +E +  +   L ++P EI +   +L  L +  N +  +PK   +L N+R+L   +N I+ 
Sbjct: 190 LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248

Query: 74  LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
            P ++     L  L + +N +  IP+++   K L + +   N L+  P     L  L  L
Sbjct: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308

Query: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
            L    + +LP ++  L NL TL +  N L  L   +  L+K+++L L  N LEV+   +
Sbjct: 309 DLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368

Query: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
                LR L LD+N L  +P ++     L CL +S+N+L ELP  +  L  L  L +++N
Sbjct: 369 ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            + ++ D I  L  +  L+   N + +V   I +C+ + ++ L+ N +M  P  L  L  
Sbjct: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV-----------------------L 350
           L  L+V+ N++  +P +I     L  L L +N+L +                       +
Sbjct: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548

Query: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393
           P  +++   LHVL +  N+ ++ P  L  L NL+ L L+ENQ Q
Sbjct: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQ 592



 Score =  152 bits (385), Expect = 2e-36
 Identities = 108/356 (30%), Positives = 172/356 (48%), Gaps = 1/356 (0%)

Query: 37  SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
           +LE L L  N+LR +P     L  LR L L  N++   P  +    +L+ LD++ N I  
Sbjct: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317

Query: 97  IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156
           +P+ I+  K LE      N L+ L     QL  +  L L D  L+ +   + N   L  L
Sbjct: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377

Query: 157 ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216
            L +NLLK++P  +S    LE L L  N L  LP  +  L NLR+L ++RN +  +   +
Sbjct: 378 ILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCI 437

Query: 217 GNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQN 276
            +L  +  L+ S N + ++P E+     +  + LS N +   P G+  L  L  L V+ N
Sbjct: 438 SHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497

Query: 277 RLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336
            + E+   I   + L  L L+EN L+        L  L  L++ +N ++ +P  I   ++
Sbjct: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557

Query: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391
           L VL L  N+    P EL     L VLD++ N+LQ +   + +L  ++ L  + NQ
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613



 Score =  147 bits (370), Expect = 1e-34
 Identities = 109/370 (29%), Positives = 177/370 (47%), Gaps = 3/370 (0%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELP-KPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82
           LQ  P++I +  + ++ L LD NQ++         LL L  L L +N +  LP E+    
Sbjct: 153 LQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLH 211

Query: 83  QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142
            L  L+VS N I  IP+ I     +    F  N +   P     L +L  L+L    L+ 
Sbjct: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271

Query: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
           +P  + +L  L  L L  N L + P +L FL KL  LDL GN +  LP  +  L NL  L
Sbjct: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331

Query: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI 262
            +D N+L+ L  E+  L ++  L +++N+LE +  ++     L  L+L +NLL+ +P+ I
Sbjct: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391

Query: 263 GQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRN 322
                L  L +  N+L E+ + I    NL +L +  N ++ +   +  L  + +L    N
Sbjct: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451

Query: 323 HLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALT-HLN 381
            +  +P EI  C  +  + L  N++   P  L     L+ L V GN +  +P  ++    
Sbjct: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511

Query: 382 LKALWLAENQ 391
           L  L L+EN+
Sbjct: 512 LLHLELSENK 521



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 4/248 (1%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           +  +P +I  +S+ L  L L  N+L    + F  L+NL+ L L  N+I+++P  ++N + 
Sbjct: 499 ISEIPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557

Query: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143
           L  L +  N     P  +   + L++ D S N L ++      L+ +  L  +       
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617

Query: 144 PGDVGNLANLVTL---ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200
           P ++  L +L  L   +++   L  LP  LS + +L++LD+  N +  +P  +G L NL 
Sbjct: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLV 677

Query: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
            L    NQ+S LPP L +L  L  L++S N L  LP+ +  +  L ++    N L R P 
Sbjct: 678 SLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPV 737

Query: 261 GIGQLKQL 268
            I + KQL
Sbjct: 738 EICKGKQL 745



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 61/201 (30%), Positives = 106/201 (52%), Gaps = 3/201 (1%)

Query: 37  SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
           SL  L+L  N+    P+    L NL+ L LS+N++Q++  ++ N   + +L+ S N    
Sbjct: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616

Query: 97  IPESIKFCKALE---IADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANL 153
            P  +   ++LE   I+   G  L+RLP   + +  L  L +++ +++ +P ++G L NL
Sbjct: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676

Query: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213
           V+L    N +  LP SL  L  L+QL+L GN+L  LP  +  + +L+E+  D N L   P
Sbjct: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736

Query: 214 PELGNLRRLVCLDVSENRLEE 234
            E+   ++L  +     R +E
Sbjct: 737 VEICKGKQLYTIARYLQRADE 757


>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
           sapiens]
          Length = 560

 Score =  155 bits (392), Expect = 3e-37
 Identities = 122/377 (32%), Positives = 184/377 (48%), Gaps = 25/377 (6%)

Query: 17  VDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPP 76
           +D  + SL A+P EI+ ++  LEE+ L+ NQ+ E+P+   RL N+R L L  N ++ L P
Sbjct: 30  IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88

Query: 77  EVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALN 136
            +     L  LD+S N I        F  +L +  F              L +L  L L 
Sbjct: 89  ALGLLSSLESLDLSYNPI--------FSSSLVVVSF--------------LHALRELRLY 126

Query: 137 DVSLQALPGDV-GNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195
              L+ +P  +  NL +L  L L  N LK LP  +    KL ++ L  N  EV P  L  
Sbjct: 127 QTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCV 186

Query: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255
           L  L  + LD N++ A+P E+G+L  L    ++ N L  LPA L     L+ L LS NLL
Sbjct: 187 LYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLL 246

Query: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315
             +P    +L++++ + +  NRL +V   I    +L  L L    L  L  S   L  L 
Sbjct: 247 HSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLR 306

Query: 316 NLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPF 375
            L++ +NHL   P +I     L VL L DN++  LP EL   ++L +L + GN   S P 
Sbjct: 307 FLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPE 366

Query: 376 ALTHL-NLKALWLAENQ 391
            +  L +L+ L++ ++Q
Sbjct: 367 EVLSLASLEKLYIGQDQ 383



 Score =  155 bits (392), Expect = 3e-37
 Identities = 123/407 (30%), Positives = 188/407 (46%), Gaps = 29/407 (7%)

Query: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN-LRKLGLSDNEIQ 72
           +ES+D  +  + +    +  +  +L EL L    L+E+P   F+ L+ L  LGL+ N ++
Sbjct: 96  LESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLK 155

Query: 73  RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
            LP E+ N  +L E+ + RN     P+ +     LEI D   N +  +P+    L  L  
Sbjct: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQK 215

Query: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLP-- 190
             +   +L  LP  +   + L  L+L  NLL S+P S + L K+ ++ L GN LE +P  
Sbjct: 216 FYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRL 275

Query: 191 ---------------------DTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSE 229
                                 +   L NLR L L +N L   P ++  L+ L  L + +
Sbjct: 276 ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDD 335

Query: 230 NRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQN---RLCEVTEAIG 286
           N++ +LP+ELG L  L  L L+ N     P+ +  L  L  L + Q+   +L  V E I 
Sbjct: 336 NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIR 395

Query: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNR 346
             ++L EL +  N L  LP SLG +  L  L+   N L+ LP  I    AL  L L DN 
Sbjct: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455

Query: 347 LAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALW--LAENQ 391
           L  LP  L     L VL +  N ++  P  +     +A+W  L EN+
Sbjct: 456 LTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENR 502



 Score =  153 bits (386), Expect = 1e-36
 Identities = 111/358 (31%), Positives = 174/358 (48%), Gaps = 6/358 (1%)

Query: 2   LKCIP--LWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLL 59
           LK IP  +++   H+E +      L+ +P+EI   ++ L E+ L  NQ    P+    L 
Sbjct: 130 LKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLY 188

Query: 60  NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 119
            L  + L +N+I  +P E+ +   L +  ++ N++P +P S+  C  L + D S N L  
Sbjct: 189 TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHS 248

Query: 120 LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
           +P  F +LR +  + L+   L+ +P  +    +L  L L    L  L  S   LV L  L
Sbjct: 249 IPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFL 308

Query: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239
           DL  N L   P  + AL NL  L LD N++  LP ELG+L +L  L ++ N     P E+
Sbjct: 309 DLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEV 368

Query: 240 GGLVLLTDLLLSQN---LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELIL 296
             L  L  L + Q+    L  +P+ I +L+ L  L ++ N L  +  ++G   NL  L  
Sbjct: 369 LSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDC 428

Query: 297 TENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL 354
             NLL  LP ++ +   L  L ++ N L  LP  +   V L VL+L DN +   P E+
Sbjct: 429 RHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 53/219 (24%), Positives = 85/219 (38%), Gaps = 49/219 (22%)

Query: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
           R   +D S   L  +P E+     L ++ L  N +  +P  I +LK + +L +D+N L  
Sbjct: 26  RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRS 85

Query: 281 VTEAIG------------------------------------------------DCENLS 292
           +  A+G                                                +  +L 
Sbjct: 86  LCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLE 145

Query: 293 ELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPP 352
            L LT N L  LP+ +   TKL  + + RN  E  P E+     L ++ L +N++  +P 
Sbjct: 146 LLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPE 205

Query: 353 ELAHTTELHVLDVAGNRLQSLPFALTHLN-LKALWLAEN 390
           E+ H T L    +A N L  LP +L   + L  L L+ N
Sbjct: 206 EIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHN 244


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score =  152 bits (384), Expect = 3e-36
 Identities = 133/416 (31%), Positives = 194/416 (46%), Gaps = 91/416 (21%)

Query: 717  IEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VR 775
            +    IE E   +T+ R   GLG SIAGG  + P+ GDD GIFI+++   G AA  G +R
Sbjct: 36   VNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPGGAAAEDGRLR 94

Query: 776  VGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYS 835
            V D +L VN V +    H +AVEAL+ AG+ V++ V R R +  E  V I          
Sbjct: 95   VNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-ETVVEIK--------- 144

Query: 836  PRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVS 895
                                         L +  +GLGFSIAGG G+  +  GD  I+V+
Sbjct: 145  -----------------------------LFKGPKGLGFSIAGGVGNQ-HIPGDNSIYVT 174

Query: 896  RIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREA----G 951
            +I +GGAA + G LQVGDR+L +N   + E  H+ AV++L   S  + L + +       
Sbjct: 175  KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMT 234

Query: 952  GPLPPSPLPHS-SPP------TAAVATTSITTATPGV-PGLPSLAPSLL----------- 992
             P  P  + HS SPP      +    T    T+ P + PG  S  P  +           
Sbjct: 235  DPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQ 294

Query: 993  --------------AAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038
                          A +LEG     ++ L +    LG +IVGG D           G+F+
Sbjct: 295  HSTATRQPSMTLQRAVSLEG--EPRKVVLHKGSTGLGFNIVGGEDGE---------GIFV 343

Query: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
            S +L  G A  SG L+ GD+IL+VNG D+R A+H++A +AL      ++++ +  P
Sbjct: 344  SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 399



 Score =  124 bits (311), Expect = 7e-28
 Identities = 98/258 (37%), Positives = 134/258 (51%), Gaps = 26/258 (10%)

Query: 1000 YPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRI 1058
            Y  EEI L R    LG SI GG+D+   P    +PG+FI+K++P G AA  G LRV D I
Sbjct: 43   YEFEEITLERGNSGLGFSIAGGTDN---PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99

Query: 1059 LAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD-PAPPGLRELCIQKAPGERLGISIRG 1117
            L VN  DV + +H +AV AL      + L VRR  P    + E+ + K P + LG SI G
Sbjct: 100  LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGP-KGLGFSIAG 158

Query: 1118 GARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
            G     GN   P D  I+++K+   GAA +DGRL+VG RLL VN  SL  +TH EAV +L
Sbjct: 159  GV----GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAIL 214

Query: 1178 RS--------VGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDR 1229
            ++        VG   T+ + D +    D     SP +  +  +   G+  +LE  +S   
Sbjct: 215  KNTSEVVYLKVGKPTTIYMTDPY-GPPDITHSYSPPMENHLLS---GNNGTLEYKTS--- 267

Query: 1230 ELSPEGPGKEKELPGQTL 1247
             L P  PG+   +P   L
Sbjct: 268  -LPPISPGRYSPIPKHML 284



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 8/98 (8%)

Query: 711 QANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAA 770
           Q +  L     +E E   + + + + GLG +I GG+       D EGIF+S +   GPA 
Sbjct: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE-------DGEGIFVSFILAGGPAD 353

Query: 771 RAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAV 807
            +G ++ GD++L VNG+ L+GA H +A  AL+GAG  V
Sbjct: 354 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 391



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 47/184 (25%), Positives = 79/184 (42%), Gaps = 23/184 (12%)

Query: 1070 THQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDP 1129
            +H +  +A  +P + L   V  +  P   R++ + K     LG +I GG  G        
Sbjct: 291  SHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-STGLGFNIVGGEDG-------- 338

Query: 1130 TDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV- 1188
              EGIF+S +   G A   G L+ G ++L VN   L G +H +A   L+  G T+T++  
Sbjct: 339  --EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396

Query: 1189 -----CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELP 1243
                    FEA      ++   ++ +  ++G G   + +  S   R +      K+  LP
Sbjct: 397  YQPEDYARFEAKIH---DLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLP 453

Query: 1244 GQTL 1247
             Q L
Sbjct: 454  SQGL 457


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score =  150 bits (379), Expect = 1e-35
 Identities = 147/497 (29%), Positives = 215/497 (43%), Gaps = 118/497 (23%)

Query: 726  ELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVN 784
            E T+ I +   GLG+SI GG  +         I I  V EEG A + G +  GD++LEVN
Sbjct: 1627 ETTIEISKGRTGLGLSIVGGSDTLL-----GAIIIHEVYEEGAACKDGRLWAGDQILEVN 1681

Query: 785  GVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGL 844
            G+ L+ A H EA+  LR     V++ ++R+     E  V  T                  
Sbjct: 1682 GIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT------------------ 1723

Query: 845  RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAH 904
             L +   + PG              +GLG SI G       +  D G+FVS I +GG A 
Sbjct: 1724 -LTIELQKKPG--------------KGLGLSIVG-------KRNDTGVFVSDIVKGGIAD 1761

Query: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964
              G L  GD++L +NG DV  A  +   +LL  +             G L     P S  
Sbjct: 1762 ADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE------------GSLSSFTFPLSGS 1809

Query: 965  PTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDH 1024
             T+    +             S   + LA+ ++G   VE  + P     LG+SI GG   
Sbjct: 1810 STSESLES-------------SSKKNALASEIQGLRTVEMKKGPT--DSLGISIAGG--- 1851

Query: 1025 SSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRILAVNGQDVRDATHQEAV-------- 1075
               P G  +  +FI+ + P G+AA++  LRVGDRI+ + G      TH +AV        
Sbjct: 1852 VGSPLG--DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG 1909

Query: 1076 ------------------------SALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERL 1111
                                    S+L    L  S + + D  PP  + + +++ P + L
Sbjct: 1910 SIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGP-DGL 1968

Query: 1112 GISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHG 1171
            G SI GG     G+P    D  I++  V   GAA  DGRL+ G +++ VN QSL G+TH 
Sbjct: 1969 GFSIVGG----YGSPHG--DLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2022

Query: 1172 EAVQLLRSVGDTLTVLV 1188
            EAV +L+    T+T++V
Sbjct: 2023 EAVAILKRTKGTVTLMV 2039



 Score =  137 bits (344), Expect = 1e-31
 Identities = 140/504 (27%), Positives = 216/504 (42%), Gaps = 81/504 (16%)

Query: 737  GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795
            GLG+S+AG K  +        +FI  +   G A + G +++ D+LLE+NG  L G  H  
Sbjct: 1359 GLGLSLAGNKDRSRMS-----VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQN 1413

Query: 796  AVEALRGAGTAVQMRVWRERMVEPENAV----TITPLRPEDDYSPRERRGGGLRLPLLPP 851
            A   ++ A + V++   R +    + AV     + PL    +    +     +       
Sbjct: 1414 ASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAV 1473

Query: 852  ESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQV 911
            +       +H+  L + + GLG +I+     +       G+ +  + E G A   G L+V
Sbjct: 1474 DLSSFKNVQHLE-LPKDQGGLGIAISEEDTLS-------GVIIKSLTEHGVAATDGRLKV 1525

Query: 912  GDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE-------------AGG------ 952
            GD++L+++   V     +  +SLL  A  T+ L +  E             A G      
Sbjct: 1526 GDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSS 1585

Query: 953  -----PLPPSPLPHSSPPTAAVATTSITTATPGV-PGLPSLAPSLLAAALEGPYPVEEIR 1006
                 P   SP P S   T+  +T +I  + P   P +P    ++            EI 
Sbjct: 1586 QSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTI------------EIS 1633

Query: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 1065
              R G  LGLSIVGGSD            + I +V   G A + G L  GD+IL VNG D
Sbjct: 1634 KGRTG--LGLSIVGGSD-------TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684

Query: 1066 VRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELC------IQKAPGERLGISIRGGA 1119
            +R ATH EA++ L +    + L + RD AP    E+C      +QK PG+ LG+SI G  
Sbjct: 1685 LRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKR 1744

Query: 1120 RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
                       D G+F+S +   G A  DGRL  G ++L VN + +   T      LL+ 
Sbjct: 1745 N----------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKV 1794

Query: 1180 VGDTLTVLVCDGFEASTDAALEVS 1203
               +L+        +ST  +LE S
Sbjct: 1795 SEGSLSSFTFPLSGSSTSESLESS 1818



 Score =  133 bits (335), Expect = 1e-30
 Identities = 141/529 (26%), Positives = 218/529 (41%), Gaps = 134/529 (25%)

Query: 729  LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVA 787
            L + +  GGLGI+I+        +    G+ I  ++E G AA  G ++VGD++L V+   
Sbjct: 1484 LELPKDQGGLGIAISE-------EDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEI 1536

Query: 788  LQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLP 847
            + G    + +  L+ A   V++ +  E    P++     P         ++     L +P
Sbjct: 1537 VVGYPIEKFISLLKTAKMTVKLTIHAEN---PDSQAV--PSAAGAASGEKKNSSQSLMVP 1591

Query: 848  LLPPESPGPLRQRH------------VAC-----------LARSERGLGFSIAGGKGSTP 884
                  P  +R                 C           +++   GLG SI GG  +  
Sbjct: 1592 QSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLL 1651

Query: 885  YRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944
                   I +  + E GAA + G L  GD++L +NG+D+ +A HD A+++L      + L
Sbjct: 1652 -----GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706

Query: 945  LLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEE 1004
             L R+                                               E PY  EE
Sbjct: 1707 TLYRD-----------------------------------------------EAPYKEEE 1719

Query: 1005 I-------RLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGD 1056
            +          + G  LGLSIVG  +         + GVF+S ++  G+A   G L  GD
Sbjct: 1720 VCDTLTIELQKKPGKGLGLSIVGKRN---------DTGVFVSDIVKGGIADADGRLMQGD 1770

Query: 1057 RILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAP--------------------- 1095
            +IL VNG+DVR+AT QEAV+ALL+   E SL     P                       
Sbjct: 1771 QILMVNGEDVRNAT-QEAVAALLKVS-EGSLSSFTFPLSGSSTSESLESSSKKNALASEI 1828

Query: 1096 PGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGL 1155
             GLR + ++K P + LGISI GG     G      D  IFI+ + PTG A +  +LRVG 
Sbjct: 1829 QGLRTVEMKKGPTDSLGISIAGGVGSPLG------DVPIFIAMMHPTGVAAQTQKLRVGD 1882

Query: 1156 RLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSP 1204
            R++ +   S  G+TH +AV LL++   ++ + V  G + S     +  P
Sbjct: 1883 RIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEP 1931



 Score =  112 bits (281), Expect = 2e-24
 Identities = 143/563 (25%), Positives = 216/563 (38%), Gaps = 148/563 (26%)

Query: 738  LGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
            LGISI GG+G      + E   GIFI  V E+ PA + G ++ GD+++EV+G+ L+ A H
Sbjct: 1162 LGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221

Query: 794  HEAVEALRGAGTAVQMRVWR--------------ERMVEPENAVTITP----LRPEDDYS 835
             +AVEA+R AG  V   V                  +    N  +  P    L+   D +
Sbjct: 1222 EQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281

Query: 836  PRERRGGGLRLPL--LPPESPGP--------------------------------LRQR- 860
            P +      + PL  +PP  P                                  +R+R 
Sbjct: 1282 PSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERY 1341

Query: 861  -------HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGD 913
                   H+  L +   GLG S+AG K  +        +F+  I   GAA + G LQ+ D
Sbjct: 1342 GTLTGELHMIELEKGHSGLGLSLAGNKDRSRM-----SVFIVGIDPNGAAGKDGRLQIAD 1396

Query: 914  RVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTS 973
             +L ING  +    H +A S++  A   + ++  R        +  P +    A     S
Sbjct: 1397 ELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGN----AVEPLPS 1452

Query: 974  ITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQE 1033
             +         P++  S  A  L     V+ + LP+  G LG++I      S        
Sbjct: 1453 NSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLS-------- 1504

Query: 1034 PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD 1092
             GV I  +   G+AA  G L+VGD+ILAV+ + V     ++ +S L    + + L +  +
Sbjct: 1505 -GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAE 1563

Query: 1093 --------------------------------PAPPGLR--------------------- 1099
                                            P P  +R                     
Sbjct: 1564 NPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPII 1623

Query: 1100 ---ELCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGL 1155
               E  I+ + G   LG+SI GG+        D     I I +V   GAA +DGRL  G 
Sbjct: 1624 PGCETTIEISKGRTGLGLSIVGGS--------DTLLGAIIIHEVYEEGAACKDGRLWAGD 1675

Query: 1156 RLLEVNQQSLLGLTHGEAVQLLR 1178
            ++LEVN   L   TH EA+ +LR
Sbjct: 1676 QILEVNGIDLRKATHDEAINVLR 1698



 Score =  103 bits (256), Expect = 2e-21
 Identities = 101/353 (28%), Positives = 158/353 (44%), Gaps = 83/353 (23%)

Query: 871  GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEA-RHD 929
            GLGFS+ G +       G+ GIFV  I EG  AHR G L+  D++L+ING  + +   H 
Sbjct: 147  GLGFSVVGLRSEN---RGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203

Query: 930  HAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAP 989
             A+S+L  A  T+ L++ R   G LP    P  S   +A +T S                
Sbjct: 204  QAISILQKAKDTVQLVIAR---GSLPQLVSPIVSRSPSAASTIS---------------- 244

Query: 990  SLLAAALEGPYP---VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGL 1046
                 A   P     +E I L   G  LG  I+GG          +  GV +  +LP G+
Sbjct: 245  -----AHSNPVHWQHMETIELVNDGSGLGFGIIGG----------KATGVIVKTILPGGV 289

Query: 1047 AARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC-LELSLLVRR------------- 1091
            A + G L  GD IL +   D+   +  E V+ +LR C   + L++ R             
Sbjct: 290  ADQHGRLCSGDHILKIGDTDLAGMS-SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALG 348

Query: 1092 ---DPAPPGLRELCIQKAP--GER--------------LGISIRGGARGHAGNPR-DPTD 1131
                 +P    EL +  +   GE               LGI+I G    + G+ + +P+ 
Sbjct: 349  ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAG----YIGDKKLEPS- 403

Query: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTL 1184
             GIF+  ++ + A   DGR+++G +++ V+  +L G T+ +AV++LR  G T+
Sbjct: 404  -GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTV 455



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 126/597 (21%), Positives = 226/597 (37%), Gaps = 148/597 (24%)

Query: 712  ANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR 771
            A  ++++    E  E T+ I +    LG++++  K       D  G+ +  +   G  +R
Sbjct: 992  AECVMLQNVSKESFERTINIAKGNSSLGMTVSANK-------DGLGMIVRSIIHGGAISR 1044

Query: 772  AG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRP 830
             G + +GD +L +N  +     + +A   LR           R  ++ P+  +T  P   
Sbjct: 1045 DGRIAIGDCILSINEESTISVTNAQARAMLR-----------RHSLIGPDIKITYVPAEH 1093

Query: 831  EDDY--SPRERRGG-----------GLRLPLLPPESPGPLRQ--------------RHVA 863
             +++  S  ++ G            G  +P LP    G   +              R V 
Sbjct: 1094 LEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVE 1153

Query: 864  CLARSERGLGFSIAGGKG-STPYRAGDA--GIFVSRIAEGGAAHRAGTLQVGDRVLSING 920
                  + LG SI GG+G  +    G+   GIF+  + E   A + GTL+ GDR++ ++G
Sbjct: 1154 LWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDG 1213

Query: 921  VDVTEARHDHAV-SLLTAASPTIAL---LLEREAGGPLP--------------PSPLPHS 962
            +D+ +A H+ AV ++  A +P + +   ++ R    PLP               +P   S
Sbjct: 1214 MDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADS 1273

Query: 963  SPPTAAVATTSITTATPGVP--GLPSLAPSLLA--------------------------- 993
                A  A +   +     P   +P   PS  A                           
Sbjct: 1274 LQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYS 1333

Query: 994  --------AALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRG 1045
                      L G   + E+    +G  LGLS+ G  D S          VFI  + P G
Sbjct: 1334 WKNIRERYGTLTGELHMIELEKGHSG--LGLSLAGNKDRS-------RMSVFIVGIDPNG 1384

Query: 1046 LAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELC-- 1102
             A + G L++ D +L +NGQ +   +HQ A S +     ++ ++  R+        +C  
Sbjct: 1385 AAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPG 1444

Query: 1103 --IQKAPG-----------------------------ERLGISIRGGARGHAGNPRDPTD 1131
              ++  P                              + L +    G  G A +  D T 
Sbjct: 1445 NAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEED-TL 1503

Query: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
             G+ I  ++  G A  DGRL+VG ++L V+ + ++G    + + LL++   T+ + +
Sbjct: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 129/537 (24%), Positives = 210/537 (39%), Gaps = 107/537 (19%)

Query: 728  TLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGV 786
            T+ ++    GLG  I GGK +        G+ +  +   G A + G +  GD +L++   
Sbjct: 257  TIELVNDGSGLGFGIIGGKAT--------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308

Query: 787  ALQGAEHHEAVEALRGAGTAVQMRVWRERMVE--PENAVTITPLRPEDDYSPRERRGGGL 844
             L G    +  + LR  G  V++ + R  + E     A+ IT L      +P  R     
Sbjct: 309  DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGIT-LSSSPTSTPELRVDAST 367

Query: 845  RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAH 904
            +         G   +     L ++ +GLG +IAG  G    +   +GIFV  I +  A  
Sbjct: 368  Q--------KGEESETFDVELTKNVQGLGITIAGYIGDK--KLEPSGIFVKSITKSSAVE 417

Query: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL-------EREAGGPLPPS 957
              G +Q+GD++++++G ++    +  AV +L     T+ L L       E E       +
Sbjct: 418  HDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVT 477

Query: 958  PLPHSSPPTAAV------------ATTSITTATP-GVPGLPSLAPSLLAAALEGPYPVEE 1004
                 SP  A++            ++T  T   P    G P L+  +    +E     E 
Sbjct: 478  KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEI--EEIEDAQKQEA 535

Query: 1005 IRLPRAGGPLGLS---IVGGSDHSSHPFGV---QEPGV---FISKVLPRGLAARSG-LRV 1054
              L +    +G++   +V      S   G+    E  V   FI  VLP G    SG L  
Sbjct: 536  ALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFS 595

Query: 1055 GDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLR------ELC---IQK 1105
            GD +L VNG  +    HQ+ V+ L    +E++++  R   PP  +      +LC   + +
Sbjct: 596  GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655

Query: 1106 AP----GERLG----------------------------------ISIRGGARG------ 1121
             P    GE +G                                  I +  G++G      
Sbjct: 656  KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715

Query: 1122 HAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
               +P DP    I I  + P G A +DGRL  G RL+ VN  +L   +  EAV+ L+
Sbjct: 716  DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772



 Score = 84.3 bits (207), Expect = 9e-16
 Identities = 98/416 (23%), Positives = 164/416 (39%), Gaps = 76/416 (18%)

Query: 723  EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 781
            E E   + + +   GLGI+IAG  G    K +  GIF+  +++       G +++GD+++
Sbjct: 372  ESETFDVELTKNVQGLGITIAGYIGDK--KLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429

Query: 782  EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSP----- 836
             V+G  LQG  + +AVE LR  G  V + + R  M +    ++   +  + D SP     
Sbjct: 430  AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489

Query: 837  --------RERRGGGLRLPLLPPESPG-PL-----------RQRHVACLARSER--GLGF 874
                     +         +LP E  G PL           +++  A L + +R  G+ +
Sbjct: 490  IKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINY 549

Query: 875  SIAGGKGSTPYRAGDAGI---------FVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925
             I     S        GI         F+  +   G    +G L  GD +L +NG+ +  
Sbjct: 550  EIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLG 609

Query: 926  ARHDHAVSLLTAASPTIALLLEREAGGPLPPSPL-------------PH---------SS 963
              H   V++L      + ++  R    P   S L             PH         S 
Sbjct: 610  ENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSE 669

Query: 964  PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSD 1023
                 +A T    +T  V      AP  +  A      ++ I L +    LG SI+   D
Sbjct: 670  TEDPVLAMTDAGQSTEEVQ-----APLAMWEA-----GIQHIELEKGSKGLGFSILDYQD 719

Query: 1024 HSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
                P       + I  ++P G+A + G L  GDR++ VN  ++ +++ +EAV AL
Sbjct: 720  ----PIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL 771



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 86/319 (26%), Positives = 127/319 (39%), Gaps = 64/319 (20%)

Query: 664 EEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIE 723
           EEEG P    E EE E+  ++E A   +  +         + G++++      I  A + 
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQR---------IMGINYE------IVVAHVS 557

Query: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLE 782
           +         +  GLGIS+    G           FI  V  EGP   +G +  GD+LLE
Sbjct: 558 K-------FSENSGLGISLEATVGHH---------FIRSVLPEGPVGHSGKLFSGDELLE 601

Query: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPL---------RPEDD 833
           VNG+ L G  H + V  L+     V M V   R V P     +  L         +P  D
Sbjct: 602 VNGITLLGENHQDVVNILKELPIEVTM-VCCRRTVPPTTQSELDSLDLCDIELTEKPHVD 660

Query: 834 YSPRERRGGG-LRLPLLPPESPGPLRQRHVACLA------------RSERGLGFSIAGGK 880
               E  G      P+L     G   +   A LA            +  +GLGFSI   +
Sbjct: 661 LG--EFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQ 718

Query: 881 GSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA-S 939
              P       I +  +  GG A + G L  GDR++ +N V++  +  + AV  L  A S
Sbjct: 719 --DPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPS 776

Query: 940 PTIALLLEREAGGPLPPSP 958
            T+ + + +    PLP SP
Sbjct: 777 GTVRIGVAK----PLPLSP 791



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 56/218 (25%), Positives = 97/218 (44%), Gaps = 46/218 (21%)

Query: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
            V E+  P +GG LG S+VG    +       E G+F+ ++    +A R G L+  D+ILA
Sbjct: 137  VFELLKPPSGG-LGFSVVGLRSENRG-----ELGIFVQEIQEGSVAHRDGRLKETDQILA 190

Query: 1061 VNGQDV-RDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAP------------ 1107
            +NGQ + +  THQ+A+S L +    + L++ R   P  +  + + ++P            
Sbjct: 191  INGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPI-VSRSPSAASTISAHSNP 249

Query: 1108 --------------GERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153
                          G  LG  I GG              G+ +  + P G A + GRL  
Sbjct: 250  VHWQHMETIELVNDGSGLGFGIIGGKA-----------TGVIVKTILPGGVADQHGRLCS 298

Query: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG 1191
            G  +L++    L G++  +  Q+LR  G+ + +++  G
Sbjct: 299  GDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARG 336



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 30/88 (34%), Positives = 46/88 (52%), Gaps = 3/88 (3%)

Query: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
            AGN +D +   +FI  + P GAAG+DGRL++   LLE+N Q L G +H  A  +++    
Sbjct: 1365 AGN-KDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPS 1423

Query: 1183 TLTVLVCDGFEASTDAALEVSPGVIANP 1210
             + ++     +A    A  V PG    P
Sbjct: 1424 KVKIIFIRNKDAVNQMA--VCPGNAVEP 1449



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 22/55 (40%), Positives = 31/55 (56%)

Query: 1135 FISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189
            FI  V P G  G  G+L  G  LLEVN  +LLG  H + V +L+ +   +T++ C
Sbjct: 577  FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCC 631


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score =  149 bits (376), Expect = 2e-35
 Identities = 156/545 (28%), Positives = 229/545 (42%), Gaps = 126/545 (23%)

Query: 738  LGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
            LGISI GG+       + E   GIFI +V E+ PA +   ++ GDK+LEV+GV LQ A H
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138

Query: 794  HEAVEALRGAGT----AVQMRVWRERMVE--PENAVTITPLRPEDDYSPRERRGGGLRLP 847
             EAVEA++ AG      VQ      R++      A  IT  + +D    +E+R G    P
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198

Query: 848  L-LPPE-----------------SPGPLRQR--------HVACLARSERGLGFSIAGGKG 881
            + LPP                  +   +RQR        H+  L + + GLG S+AG K 
Sbjct: 1199 MKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKD 1258

Query: 882  STPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPT 941
             +        IFV  I   G A   G +++GD +L IN   +    H +A +++  A   
Sbjct: 1259 RS-----RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313

Query: 942  IALLLEREAGG----PLPPSPLPHSSPP-------TAAVATTSITTATPGVPGLPSLAPS 990
            + L+  R         + P P+P SSP        T  +++    +   G+  LP     
Sbjct: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373

Query: 991  LLAAA--------------------------------------LEGPYPVEEIRLPRAGG 1012
             LA +                                       + P  V+    P   G
Sbjct: 1374 KLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPG 1433

Query: 1013 P------------LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRIL 1059
                         LGLSIVGG D   +        + I +V   G AAR G L  GD+IL
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN-------AIVIHEVYEEGAAARDGRLWAGDQIL 1486

Query: 1060 AVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE------LCIQKAPGERLGI 1113
             VNG D+R+++H+EA++AL +   ++ L+V RD A     E      + +QK  G  LG+
Sbjct: 1487 EVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGL 1546

Query: 1114 SIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEA 1173
            SI G   G           G+FIS +   GAA  DGRL  G ++L VN + +   +    
Sbjct: 1547 SIVGKRNG----------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596

Query: 1174 VQLLR 1178
              +L+
Sbjct: 1597 ATILK 1601



 Score =  122 bits (306), Expect = 3e-27
 Identities = 120/379 (31%), Positives = 177/379 (46%), Gaps = 67/379 (17%)

Query: 715  LLIEPAR---IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR 771
            L ++PA    +  +E+ + I +   GLG+SI GGK  TP       I I  V EEG AAR
Sbjct: 1421 LSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGK-DTPLNA----IVIHEVYEEGAAAR 1475

Query: 772  AG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRP 830
             G +  GD++LEVNGV L+ + H EA+ ALR     V++ V+R+                
Sbjct: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD---------------- 1519

Query: 831  EDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDA 890
            E  Y   E       L + P           V    ++ RGLG SI G +  +       
Sbjct: 1520 EAHYRDEEN------LEIFP-----------VDLQKKAGRGLGLSIVGKRNGS------- 1555

Query: 891  GIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER-E 949
            G+F+S I +GGAA   G L  GD++LS+NG D+  A  +   ++L  A   + L + R  
Sbjct: 1556 GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLR 1615

Query: 950  AGGPLPPSPLPHSSPPTAAVATTSI-TTATPGVPGLPSLA-------PSLLAAALE-GPY 1000
            AG          +S  +   A +S   +  P + GL +L        PS   +  +  P 
Sbjct: 1616 AGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPR 1675

Query: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRIL 1059
             VE  R       LG+SI GG      P G  +  VFI+ +   G+AAR+  L+VGDRI+
Sbjct: 1676 TVEINR--ELSDALGISIAGG---RGSPLG--DIPVFIAMIQASGVAARTQKLKVGDRIV 1728

Query: 1060 AVNGQDVRDATHQEAVSAL 1078
            ++NGQ +   +H + V+ L
Sbjct: 1729 SINGQPLDGLSHADVVNLL 1747



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 109/423 (25%), Positives = 174/423 (41%), Gaps = 98/423 (23%)

Query: 819  PENAVTITPLRP-------EDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERG 871
            P N  T++ L P       ED  S  ++   G ++  +  E P             S  G
Sbjct: 98   PSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERP-------------STGG 144

Query: 872  LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE-ARHDH 930
            LGFS+   +       G   IFV  +  G  A R   L+  D++L+IN   + +   H  
Sbjct: 145  LGFSVVALRSQN---LGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201

Query: 931  AVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990
            A++LL   + ++ L++ RE                   V T S T+++     LP     
Sbjct: 202  AIALLQQTTGSLRLIVAREP------------------VHTKSSTSSSLNDTTLPE---- 239

Query: 991  LLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS 1050
                   G   VEE+ L   G  LG  IVGG          +  GV +  ++P GLA R 
Sbjct: 240  ---TVCWGH--VEEVELINDGSGLGFGIVGG----------KTSGVVVRTIVPGGLADRD 284

Query: 1051 G-LRVGDRILAVNGQDVRDATHQEAVSALLRPC-LELSLLVRRDPA------PPGLRELC 1102
            G L+ GD IL + G +V+  T  E V+ +LR C   + +LV RDPA      PP    L 
Sbjct: 285  GRLQTGDHILKIGGTNVQGMT-SEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALP 343

Query: 1103 I------QKAP------------------GERLGISIRGGARGHAGNPRDPTDEGIFISK 1138
            +       K P                  G+ LGI I     G+ G        GI++  
Sbjct: 344  VALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRI----VGYVGTSHTGEASGIYVKS 399

Query: 1139 VSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDA 1198
            + P  AA  +G ++V  +++ V+  ++ G  + + V++LR+ G  + + +     +S+ +
Sbjct: 400  IIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459

Query: 1199 ALE 1201
             LE
Sbjct: 460  PLE 462



 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 94/349 (26%), Positives = 149/349 (42%), Gaps = 57/349 (16%)

Query: 735  TGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AGVRVGDKLLEVNGVAL-QGAE 792
            TGGLG S+   +     K D   IF+  V     A R   ++  D++L +N   L Q   
Sbjct: 142  TGGLGFSVVALRSQNLGKVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198

Query: 793  HHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPE 852
            H +A+  L+    ++++ V RE    P +  + T     D   P     G +        
Sbjct: 199  HQQAIALLQQTTGSLRLIVARE----PVHTKSSTSSSLNDTTLPETVCWGHVE------- 247

Query: 853  SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
                        L     GLGF I GGK S        G+ V  I  GG A R G LQ G
Sbjct: 248  ---------EVELINDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTG 290

Query: 913  DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATT 972
            D +L I G +V     +    +L     ++ +L+ R+  G +  +P     P  AA+   
Sbjct: 291  DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTP-----PAPAALPVA 345

Query: 973  SITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFG 1030
              T A+ G PG  S        +L   Y VE +R  + G  LG+ IVG  G+ H+     
Sbjct: 346  LPTVASKG-PGSDS--------SLFETYNVELVR--KDGQSLGIRIVGYVGTSHTG---- 390

Query: 1031 VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
             +  G+++  ++P   A  +G ++V D+I+AV+G +++   + + V  L
Sbjct: 391  -EASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVL 438



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 74/270 (27%), Positives = 120/270 (44%), Gaps = 39/270 (14%)

Query: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
           +EE EL    +    GLG  I GGK S        G+ +  +   G A R G ++ GD +
Sbjct: 246 VEEVEL----INDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTGDHI 293

Query: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
           L++ G  +QG    +  + LR  G +V+M V R+    P   +++TP  P          
Sbjct: 294 LKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----PAGDISVTPPAPA--------- 340

Query: 841 GGGLRLPLLPPESPGP----LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSR 896
              + LP +  + PG         +V  + +  + LG  I G  G T +    +GI+V  
Sbjct: 341 ALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVG-TSHTGEASGIYVKS 399

Query: 897 IAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER----EAGG 952
           I  G AA+  G +QV D++++++GV++    +   V +L  A   + L L R     +  
Sbjct: 400 IIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459

Query: 953 PL-PPS---PLPHSSPPTAAVATTSITTAT 978
           PL PPS    +     P A   T ++ T T
Sbjct: 460 PLEPPSDRGTVVEPLKPPALFLTGAVETET 489



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 67/224 (29%), Positives = 96/224 (42%), Gaps = 26/224 (11%)

Query: 737  GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRV-GDKLLEVNGVALQGAEHHE 795
            GLG+SI G       K +  G+FIS + + G A   G  + GD++L VNG  ++ A    
Sbjct: 1543 GLGLSIVG-------KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQET 1595

Query: 796  AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPR--------------ERRG 841
                L+ A   VQ+ + R R     +A T +        S                +   
Sbjct: 1596 VATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLV 1655

Query: 842  GGLRLPLLPPESPGP-LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
            G  R+     ++ G  +  R V         LG SIAGG+GS     GD  +F++ I   
Sbjct: 1656 GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSP---LGDIPVFIAMIQAS 1712

Query: 901  GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944
            G A R   L+VGDR++SING  +    H   V+LL  A   I L
Sbjct: 1713 GVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIIL 1756



 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 70/281 (24%), Positives = 106/281 (37%), Gaps = 55/281 (19%)

Query: 836  PRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTP-YRAGDA--GI 892
            P    G G   P      P     R V         LG SI GG+      + G+   GI
Sbjct: 1047 PEREEGEGEETPNFSHWGP----PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGI 1102

Query: 893  FVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL------ 946
            F+ ++ E   A +   L+ GD++L ++GVD+  A H  AV  +  A   +  ++      
Sbjct: 1103 FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSST 1162

Query: 947  --------------------------EREAGGPLPPSPLPHSSPPTAAVATTSITTATPG 980
                                      E+  G   PP  LP   PP  A+  T  +     
Sbjct: 1163 PRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLP---PPYKAL--TDDSDENEE 1217

Query: 981  VPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISK 1040
                         A L G   + E+   + G  LGLS+ G  D S          +F+  
Sbjct: 1218 EDAFTDQKIRQRYADLPGELHIIELEKDKNG--LGLSLAGNKDRS-------RMSIFVVG 1268

Query: 1041 VLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLR 1080
            + P G AA  G +R+GD +L +N Q +   +HQ A SA+++
Sbjct: 1269 INPEGPAAADGRMRIGDELLEINNQILYGRSHQNA-SAIIK 1308



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 48/193 (24%), Positives = 87/193 (45%), Gaps = 39/193 (20%)

Query: 659  KEEEEEEEGS---------PQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSF 709
            +E++E+ +G+         P +   ++ +EN  EEE+A T+++ ++              
Sbjct: 1185 QEKKEKRQGTAPPPMKLPPPYKALTDDSDEN--EEEDAFTDQKIRQ-------------- 1228

Query: 710  DQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPA 769
                      A +  E   + + +   GLG+S+AG K  +        IF+  ++ EGPA
Sbjct: 1229 --------RYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMS-----IFVVGINPEGPA 1275

Query: 770  ARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPL 828
            A  G +R+GD+LLE+N   L G  H  A   ++ A + V++   R      + AVT  P+
Sbjct: 1276 AADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPV 1335

Query: 829  RPEDDYSPRERRG 841
                  S  ++ G
Sbjct: 1336 PSSSPSSIEDQSG 1348



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 7/104 (6%)

Query: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
            R + I +   + LGISI GG     G      D  +FI+ +  +G A R  +L+VG R++
Sbjct: 1675 RTVEINRELSDALGISIAGGRGSPLG------DIPVFIAMIQASGVAARTQKLKVGDRIV 1728

Query: 1159 EVNQQSLLGLTHGEAVQLLRSV-GDTLTVLVCDGFEASTDAALE 1201
             +N Q L GL+H + V LL++  G  +  +V D   ++  A LE
Sbjct: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLE 1772



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 56/197 (28%), Positives = 80/197 (40%), Gaps = 21/197 (10%)

Query: 759 FISRVSEEGPAARAGV-RVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRE--- 814
           +IS +   GP    G+ +  D+LLEVNG+ L G    EAV  L+       +   R    
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641

Query: 815 ---RMVEPENAVTITPLRPED---DYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARS 868
               + EP    T  P    D   D +  E   G   L L  PE         +  L + 
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDG--ELALWSPEV-------KIVELVKD 692

Query: 869 ERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARH 928
            +GLGFSI   +   P     + I +  +   G A R+G L  GDR++S+N   +     
Sbjct: 693 CKGLGFSILDYQ--DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750

Query: 929 DHAVSLLTAASPTIALL 945
             AV +L A  P +  L
Sbjct: 751 AEAVEILKAVPPGLVHL 767



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 32/104 (30%), Positives = 55/104 (52%), Gaps = 3/104 (2%)

Query: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
            AGN +D +   IF+  ++P G A  DGR+R+G  LLE+N Q L G +H  A  ++++   
Sbjct: 1254 AGN-KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312

Query: 1183 TLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISS 1226
             + ++     +A    A  V+P  + +   + I  ++  E ISS
Sbjct: 1313 KVKLVFIRNEDAVNQMA--VTPFPVPSSSPSSIEDQSGTEPISS 1354



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 9/117 (7%)

Query: 701  APSVKGVSFDQANNLLIEPAR----IEEEELTLTILRQ-TGGLGISIAGGKGSTPYKGDD 755
            AP + G+        + +P++     + E  T+ I R+ +  LGISIAGG+GS      D
Sbjct: 1645 APVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL---GD 1701

Query: 756  EGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRV 811
              +FI+ +   G AAR   ++VGD+++ +NG  L G  H + V  L+ A   + ++V
Sbjct: 1702 IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 11/115 (9%)

Query: 1095 PPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVG 1154
            PP + E  I + P   LGISI GG             +GIFI +V     AG+   L+ G
Sbjct: 1065 PPRIVE--IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTG 1122

Query: 1155 LRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIAN 1209
             ++LEV+   L   +H EAV+ +++ G+ +  +V          +L  +P VI N
Sbjct: 1123 DKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIV---------QSLSSTPRVIPN 1168



 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 57/222 (25%), Positives = 81/222 (36%), Gaps = 33/222 (14%)

Query: 889  DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER 948
            D   ++S I  GG     G LQ  D +L +NG+ +       AVS L    P   L+  R
Sbjct: 578  DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637

Query: 949  ----EAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEE 1004
                +      P     S P T       + T       L   +P            V+ 
Sbjct: 638  RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE-----------VKI 686

Query: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRILAVNG 1063
            + L +    LG SI+   D    P       + I  ++  G+A RS GL  GDR+++VN 
Sbjct: 687  VELVKDCKGLGFSILDYQD----PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742

Query: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQK 1105
              + + +  EAV  L                PPGL  L I K
Sbjct: 743  YCLDNTSLAEAVEIL-------------KAVPPGLVHLGICK 771



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 22/56 (39%), Positives = 31/56 (55%)

Query: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV 1180
            +P DPT   I I  +   G A R G L  G RL+ VN+  L   +  EAV++L++V
Sbjct: 705  DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 3/73 (4%)

Query: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
            D  D   +IS +   G     G L+    LLEVN   L G +  EAV  L+ V    T++
Sbjct: 575  DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634

Query: 1188 VCDGF---EASTD 1197
             C      EAS D
Sbjct: 635  CCRRLFDDEASVD 647



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 35/142 (24%), Positives = 54/142 (38%), Gaps = 25/142 (17%)

Query: 661 EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
           ++E     P+  E    E       + +TEE+D     + +P VK V             
Sbjct: 641 DDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVE------------ 688

Query: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRVGDK 779
                     +++   GLG SI   +   P       I I  +  +G A R+ G+  GD+
Sbjct: 689 ----------LVKDCKGLGFSILDYQ--DPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736

Query: 780 LLEVNGVALQGAEHHEAVEALR 801
           L+ VN   L      EAVE L+
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILK 758


>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
          Length = 817

 Score =  148 bits (373), Expect = 5e-35
 Identities = 128/390 (32%), Positives = 187/390 (47%), Gaps = 73/390 (18%)

Query: 725  EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
            EE+ L   R   GLG SIAGG  + P+  DD GIFI+++   G AA  G + V D +L V
Sbjct: 130  EEIVLE--RGNSGLGFSIAGGIDN-PHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186

Query: 784  NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843
            N V +    H  AVEAL+ AG  V++ V R R   PE  + +  L+              
Sbjct: 187  NEVDVSEVVHSRAVEALKEAGPVVRLVV-RRRQPPPETIMEVNLLK-------------- 231

Query: 844  LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903
                       GP             +GLGFSIAGG G+  +  GD  I++++I EGGAA
Sbjct: 232  -----------GP-------------KGLGFSIAGGIGNQ-HIPGDNSIYITKIIEGGAA 266

Query: 904  HRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSS 963
             + G LQ+GDR+L++N  ++ + RH+ AV+ L   S  + L + +     L     P   
Sbjct: 267  QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDY 326

Query: 964  PPT-AAVATTSIT--------------TATPGVPGLP----SLAPSLLAAALEGPYPVEE 1004
              T  A+A   I+               + P  P +P    S  P  + A  +      +
Sbjct: 327  ASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRK 386

Query: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
            I L +    LG +IVGG D           G+F+S +L  G A  SG LR GDRIL+VNG
Sbjct: 387  IILHKGSTGLGFNIVGGEDGE---------GIFVSFILAGGPADLSGELRRGDRILSVNG 437

Query: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
             ++R+ATH++A +AL R    ++++ +  P
Sbjct: 438  VNLRNATHEQAAAALKRAGQSVTIVAQYRP 467



 Score =  128 bits (322), Expect = 4e-29
 Identities = 104/301 (34%), Positives = 144/301 (47%), Gaps = 40/301 (13%)

Query: 952  GPLPPSPLPHSSPPTAAVATTSITTATPGVPGL-PSLAPSLLAA---------ALEGPYP 1001
            GP+PP P+P  S              TP + G  PS  P                +G + 
Sbjct: 83   GPVPPKPVPGKS--------------TPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFK 128

Query: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
             EEI L R    LG SI GG D+   P    +PG+FI+K++P G AA  G L V D +L 
Sbjct: 129  YEEIVLERGNSGLGFSIAGGIDNPHVP---DDPGIFITKIIPGGAAAMDGRLGVNDCVLR 185

Query: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRR-DPAPPGLRELCIQKAPGERLGISIRGGA 1119
            VN  DV +  H  AV AL      + L+VRR  P P  + E+ + K P + LG SI GG 
Sbjct: 186  VNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGP-KGLGFSIAGGI 244

Query: 1120 RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
                GN   P D  I+I+K+   GAA +DGRL++G RLL VN  +L  + H EAV  L++
Sbjct: 245  ----GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKN 300

Query: 1180 VGDTLTVLVCDGFEASTDAALEVSPGVIANPFAA----GIGHRNSLESISSIDRELSPEG 1235
              D + + V      S       +P   A+ F A     I H +SL  + +++ ++S   
Sbjct: 301  TSDMVYLKVAK--PGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPA 358

Query: 1236 P 1236
            P
Sbjct: 359  P 359



 Score =  105 bits (262), Expect = 4e-22
 Identities = 79/253 (31%), Positives = 122/253 (48%), Gaps = 39/253 (15%)

Query: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLE 782
           E  + + +L+   GLG SIAGG G+    GD+  I+I+++ E G A + G +++GD+LL 
Sbjct: 222 ETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNS-IYITKIIEGGAAQKDGRLQIGDRLLA 280

Query: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWR-------ERMVEPENAVTITPLRPEDDYS 835
           VN   LQ   H EAV +L+     V ++V +       +    P+ A T T L   D++ 
Sbjct: 281 VNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTAL--ADNHI 338

Query: 836 PRERRGGGLRL----------PLLPPESPGPL-----------RQRHVACLARSERGLGF 874
                 G L            P +PP    P+           R+     L +   GLGF
Sbjct: 339 SHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGF 398

Query: 875 SIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSL 934
           +I GG+          GIFVS I  GG A  +G L+ GDR+LS+NGV++  A H+ A + 
Sbjct: 399 NIVGGEDG-------EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAA 451

Query: 935 LTAASPTIALLLE 947
           L  A  ++ ++ +
Sbjct: 452 LKRAGQSVTIVAQ 464



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 92/338 (27%), Positives = 135/338 (39%), Gaps = 24/338 (7%)

Query: 865  LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
            L R   GLGFSIAGG  + P+   D GIF+++I  GGAA   G L V D VL +N VDV+
Sbjct: 134  LERGNSGLGFSIAGGIDN-PHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVS 192

Query: 925  EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
            E  H  AV  L  A P + L++ R    P     +     P     + +       +PG 
Sbjct: 193  EVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGD 252

Query: 985  PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSD--HSSHPFGVQEPG--VFISK 1040
             S+    +   +EG    ++ RL      L ++     D  H      ++     V++  
Sbjct: 253  NSI---YITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309

Query: 1041 VLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE 1100
              P  L         D             +H  ++  L     ++S      PAPP +  
Sbjct: 310  AKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSY-----PAPPQVPP 364

Query: 1101 LCIQKAPGERLG----------ISIRGGARGHAGNPRDPTD-EGIFISKVSPTGAAGRDG 1149
                  P   L           I +  G+ G   N     D EGIF+S +   G A   G
Sbjct: 365  TRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSG 424

Query: 1150 RLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
             LR G R+L VN  +L   TH +A   L+  G ++T++
Sbjct: 425  ELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 13/92 (14%)

Query: 722 IEEEELT-----LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VR 775
           + EE+ T     + + + + GLG +I GG+       D EGIF+S +   GPA  +G +R
Sbjct: 375 LAEEDFTREPRKIILHKGSTGLGFNIVGGE-------DGEGIFVSFILAGGPADLSGELR 427

Query: 776 VGDKLLEVNGVALQGAEHHEAVEALRGAGTAV 807
            GD++L VNGV L+ A H +A  AL+ AG +V
Sbjct: 428 RGDRILSVNGVNLRNATHEQAAAALKRAGQSV 459


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score =  147 bits (371), Expect = 8e-35
 Identities = 96/268 (35%), Positives = 138/268 (51%)

Query: 13  HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
           H+  +D  H  L A+  E+    R L +L L  NQL  LP     L +L +L +S N + 
Sbjct: 112 HLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171

Query: 73  RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
            LP  ++   +L  LDV  N +   P  +    ALE  D S N L  LP+  + LR+L  
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231

Query: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDT 192
           L L+   L  LP     LA+L +L L  N L++LPA  S L +L+ L+L  N  E  P  
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291

Query: 193 LGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQ 252
           L  L  L EL+L RNQL+++P  +  L RL+ L +  NR+  LP  +  L  L +L+L  
Sbjct: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351

Query: 253 NLLRRLPDGIGQLKQLSILKVDQNRLCE 280
           N +  LPD  GQL ++ + K+  N L +
Sbjct: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQ 379



 Score =  144 bits (363), Expect = 7e-34
 Identities = 113/313 (36%), Positives = 150/313 (47%), Gaps = 7/313 (2%)

Query: 79  ANFMQLVELDVSRNDIPEIPESI-KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALND 137
           AN   +  L++  N + E+PE +     +L +     N  +RLP    +L    HL   D
Sbjct: 60  ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGH--HLTELD 117

Query: 138 VS---LQALPGDVGN-LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
           VS   L AL  +V + L  L  L L  N L +LPA L  L  LE+LD+  N L  LPD+L
Sbjct: 118 VSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSL 177

Query: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
             L  LR L +D NQL+A P +L  L  L  LDVS NRL  LP ++  L  L  L LS  
Sbjct: 178 SCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGA 237

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            L  LP G  +L  L  L +D N L  +       + L  L L+ NL    P +L  L  
Sbjct: 238 ELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAG 297

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
           L  L + RN L ++P  I G   L  L L +NR+  LP  +   T L  L + GN++  L
Sbjct: 298 LEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVL 357

Query: 374 PFALTHLNLKALW 386
           P     L+   LW
Sbjct: 358 PDHFGQLSRVGLW 370



 Score =  144 bits (362), Expect = 9e-34
 Identities = 107/320 (33%), Positives = 163/320 (50%), Gaps = 2/320 (0%)

Query: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRL-LNLRKLGLSDNEIQ 72
           +E+++  +  L+ VPE +     SL  L+L  N+   LP     L  +L +L +S N + 
Sbjct: 65  IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124

Query: 73  RLPPEVANFM-QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLA 131
            L  EV + + +L +L++S N +P +P  +     LE  D S N L+ LPD  + L  L 
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184

Query: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPD 191
            L ++   L A P  +  L  L  L++  N L+ LP  +S L  L+ L L G +L  LP 
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244

Query: 192 TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
               L +L  L LD N L ALP +   L+RL  L++S N  EE PA L  L  L +L LS
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304

Query: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL 311
           +N L  +P  I  L +L  L +D NR+  + ++I +   L EL+L  N +  LP   G+L
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364

Query: 312 TKLTNLNVDRNHLEALPPEI 331
           +++    +  N L   P E+
Sbjct: 365 SRVGLWKIKDNPLIQPPYEV 384


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score =  145 bits (366), Expect = 3e-34
 Identities = 164/624 (26%), Positives = 262/624 (41%), Gaps = 112/624 (17%)

Query: 656  RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVV--------SAPSVKGV 707
            R Q E+   +   P+   E    E     E+  ++ E+  G V+        ++P+   V
Sbjct: 122  RYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV 181

Query: 708  SFDQANNL-LIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
            + D  + +  +    IE E   +T+ R   GLG SIAGG  + P+ GDD GIFI+++   
Sbjct: 182  NTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPG 240

Query: 767  GPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTI 825
            G AA  G +RV D +L VN V +    H +AVEAL+ AG+ V++ V R R +  E  V I
Sbjct: 241  GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-ETVVEI 299

Query: 826  TPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPY 885
                                                   L +  +GLGFSIAGG G+  +
Sbjct: 300  K--------------------------------------LFKGPKGLGFSIAGGVGNQ-H 320

Query: 886  RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
              GD  I+V++I +GGAA + G LQVGDR+L +N   + E  H+ AV++L   S  + L 
Sbjct: 321  IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 380

Query: 946  LEREAG----GPLPPSPLPHS-SPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
            + +        P  P  + HS SPP      +           LP ++P        G Y
Sbjct: 381  VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP--------GRY 432

Query: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG-DRIL 1059
                        P+   ++   D++  P  V      ++K+  +  + R    V  D+  
Sbjct: 433  -----------SPIPKHMLVDDDYTRPPEPVYST---VNKLCDKPASPRHYSPVECDKSF 478

Query: 1060 AVNGQ----------DVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGE 1109
             ++            D    +H +  +A  +P + L   V  +  P   R++ + K    
Sbjct: 479  LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-ST 534

Query: 1110 RLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
             LG +I GG  G          EGIF+S +   G A   G L+ G ++L VN   L G +
Sbjct: 535  GLGFNIVGGEDG----------EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584

Query: 1170 HGEAVQLLRSVGDTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLES 1223
            H +A   L+  G T+T++          FEA      ++   ++ +  ++G G   + + 
Sbjct: 585  HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH---DLREQMMNHSMSSGSGSLRTNQK 641

Query: 1224 ISSIDRELSPEGPGKEKELPGQTL 1247
             S   R +      K+  LP Q L
Sbjct: 642  RSLYVRAMFDYDKSKDSGLPSQGL 665


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score =  145 bits (366), Expect = 3e-34
 Identities = 164/624 (26%), Positives = 262/624 (41%), Gaps = 112/624 (17%)

Query: 656  RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVV--------SAPSVKGV 707
            R Q E+   +   P+   E    E     E+  ++ E+  G V+        ++P+   V
Sbjct: 17   RYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV 76

Query: 708  SFDQANNL-LIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
            + D  + +  +    IE E   +T+ R   GLG SIAGG  + P+ GDD GIFI+++   
Sbjct: 77   NTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPG 135

Query: 767  GPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTI 825
            G AA  G +RV D +L VN V +    H +AVEAL+ AG+ V++ V R R +  E  V I
Sbjct: 136  GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-ETVVEI 194

Query: 826  TPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPY 885
                                                   L +  +GLGFSIAGG G+  +
Sbjct: 195  K--------------------------------------LFKGPKGLGFSIAGGVGNQ-H 215

Query: 886  RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
              GD  I+V++I +GGAA + G LQVGDR+L +N   + E  H+ AV++L   S  + L 
Sbjct: 216  IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 275

Query: 946  LEREAG----GPLPPSPLPHS-SPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
            + +        P  P  + HS SPP      +           LP ++P        G Y
Sbjct: 276  VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP--------GRY 327

Query: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG-DRIL 1059
                        P+   ++   D++  P  V      ++K+  +  + R    V  D+  
Sbjct: 328  -----------SPIPKHMLVDDDYTRPPEPVYST---VNKLCDKPASPRHYSPVECDKSF 373

Query: 1060 AVNGQ----------DVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGE 1109
             ++            D    +H +  +A  +P + L   V  +  P   R++ + K    
Sbjct: 374  LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-ST 429

Query: 1110 RLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
             LG +I GG  G          EGIF+S +   G A   G L+ G ++L VN   L G +
Sbjct: 430  GLGFNIVGGEDG----------EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479

Query: 1170 HGEAVQLLRSVGDTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLES 1223
            H +A   L+  G T+T++          FEA      ++   ++ +  ++G G   + + 
Sbjct: 480  HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH---DLREQMMNHSMSSGSGSLRTNQK 536

Query: 1224 ISSIDRELSPEGPGKEKELPGQTL 1247
             S   R +      K+  LP Q L
Sbjct: 537  RSLYVRAMFDYDKSKDSGLPSQGL 560


>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
          Length = 602

 Score =  138 bits (347), Expect = 5e-32
 Identities = 114/381 (29%), Positives = 194/381 (50%), Gaps = 12/381 (3%)

Query: 86  ELDVSRNDIPEIPESIKFCKALEIADFSGNPLS-RLPDGFTQLRSLAHLALNDVSLQALP 144
           +L++S  ++ E+P+ +     ++I + +   LS    + + +   L  L +++  LQ+L 
Sbjct: 40  QLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLT 98

Query: 145 GDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204
            D+  L  L  L++ +N L SLP+++  L  L++L++  N L++LP+ +  L NL+ L+L
Sbjct: 99  DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYL 158

Query: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
             N+L+ +      L  L  LD+S N L  +PA    L  L  L LS N L+ LP  I +
Sbjct: 159 QHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINR 218

Query: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
           +K+L  L  + N L  +   +   E+L  L L  N L  LP      + L  L+V  N +
Sbjct: 219 MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQI 277

Query: 325 EALPPE-IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLK 383
           E L  E +    ++ VL LRDN+L  +P E+     L  LD++ N + SLP++L +L+LK
Sbjct: 278 EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLK 337

Query: 384 ALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAP-P 442
            L L  N   P+   + E  ++  ++VL  YL   +  +  +   Q  S +ET    P  
Sbjct: 338 FLALEGN---PLRTIRREIISKGTQEVLK-YL---RSKIKDDGPSQSESATETAMTLPSE 390

Query: 443 SRVSVIQFLEAPIGDEDAEEA 463
           SRV++   +   I D   ++A
Sbjct: 391 SRVNIHAIITLKILDYSDKQA 411



 Score =  129 bits (325), Expect = 2e-29
 Identities = 100/352 (28%), Positives = 169/352 (48%), Gaps = 13/352 (3%)

Query: 26  AVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFM--- 82
           +VP+ + + +R   +L L    L E+P+  +R+     + + +   Q L           
Sbjct: 26  SVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRI----NVDIPEEANQNLSFGATERWWEQ 81

Query: 83  -QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQ 141
             L +L +S N +  + + ++   AL + D   N L+ LP    +L +L  L ++   L+
Sbjct: 82  TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141

Query: 142 ALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRE 201
            LP ++ NL NL  L L+ N L  +      L  LE LDL  N L  +P +  +L +L  
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201

Query: 202 LWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDG 261
           L L  N+L +LP E+  ++RL  LD + N LE +P EL G+  L  L L +N LR LP+ 
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE- 260

Query: 262 IGQLKQLSILKVDQNRLCEVTEA--IGDCENLSELILTENLLMALPRSLGKLTKLTNLNV 319
                 L  L V +N++ E+ EA  +    ++  L L +N L ++P  +  L  L  L++
Sbjct: 261 FPSCSLLKELHVGENQI-EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDL 319

Query: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQ 371
             N + +LP  +G  + L  L+L  N L  +  E+       VL    ++++
Sbjct: 320 SNNDISSLPYSLGN-LHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIK 370



 Score =  127 bits (320), Expect = 7e-29
 Identities = 112/397 (28%), Positives = 197/397 (49%), Gaps = 28/397 (7%)

Query: 2   LKCIPLWRCN-RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
           LK +P    N R+++ +  +H  L  + E   + S +LE+L L  N L  +P  F  L +
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLS-NLEDLDLSNNHLTTVPASFSSLSS 198

Query: 61  LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
           L +L LS NE++ LP E+    +L  LD + N +  IP  +   ++LE+     N L  L
Sbjct: 199 LVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFL 258

Query: 121 PDGFTQLRSLAHLALNDVSLQALPGD-VGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
           P+ F     L  L + +  ++ L  + + +L +++ L+LR+N LKS+P  +  L  LE+L
Sbjct: 259 PE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERL 317

Query: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE----- 234
           DL  ND+  LP +LG L +L+ L L+ N L  +  E+ +      L    +++++     
Sbjct: 318 DLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQ 376

Query: 235 ----------LPAE----LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSI---LKVDQNR 277
                     LP+E    +  ++ L  L  S      +PD +    + +I   +   +N+
Sbjct: 377 SESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQ 436

Query: 278 LCEVTEAIGDC-ENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336
           LCE+ + + +  E +S++ L+ N L  +   L  L KLT L++  N L +LP E+   V 
Sbjct: 437 LCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496

Query: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
           L  ++L  NR  +LP  L     L  + ++ N++ S+
Sbjct: 497 LQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSV 533



 Score =  108 bits (271), Expect = 3e-23
 Identities = 105/407 (25%), Positives = 175/407 (42%), Gaps = 72/407 (17%)

Query: 13  HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
           ++E +D  +  L  VP      S SL  L L +N+L+ LP    R+  L+ L  + N ++
Sbjct: 175 NLEDLDLSNNHLTTVPASFSSLS-SLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233

Query: 73  RLPPEVANFMQLVELDVSRNDI---PEIP--------------------ESIKFCKALEI 109
            +PPE+A    L  L + RN +   PE P                    E +K   ++ +
Sbjct: 234 TIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293

Query: 110 ADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKS---- 165
            D   N L  +PD    LRSL  L L++  + +LP  +GNL +L  L L  N L++    
Sbjct: 294 LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRRE 352

Query: 166 ----------------------------------LPA----SLSFLVKLEQLDLGGNDLE 187
                                             LP+    ++  ++ L+ LD       
Sbjct: 353 IISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQAT 412

Query: 188 VLPDTL--GALPNL-RELWLDRNQLSALPPELGNLRRLVC-LDVSENRLEELPAELGGLV 243
           ++PD +      N+   +   +NQL  +P  +  L+ +V  +D+S N+L  +  EL  L 
Sbjct: 413 LIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQ 472

Query: 244 LLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMA 303
            LT L L  N L  LP+ +  L +L  + +  NR   + E +     L  ++++ N + +
Sbjct: 473 KLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532

Query: 304 L-PRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV 349
           + P+ +  +  LT L++  N L  +PPE+G CV L  L L  N   V
Sbjct: 533 VDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 579


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score =  126 bits (316), Expect = 2e-28
 Identities = 112/349 (32%), Positives = 158/349 (45%), Gaps = 9/349 (2%)

Query: 28  PEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVEL 87
           PE + +   SL  L L+   L  LP+    L  L  L +S N +  L  E+++   L  +
Sbjct: 26  PENV-KAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAI 84

Query: 88  DVSRNDIPE--IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
               N +    +P+ I     L + D S N L+  P      +++  L L+  S+  +P 
Sbjct: 85  VARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPN 144

Query: 146 DVG-NLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL-EVLPDTLGALPNLRELW 203
            +  NL +L+ L+L EN L+SLP  +  LV L+ L L GN L       L A+  L+ L 
Sbjct: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLH 204

Query: 204 LDRNQL--SALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDG 261
           L   Q   S LP  L  L  L  +D+S N L  +P  L  L  L  L LS N +  L   
Sbjct: 205 LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLC 264

Query: 262 IGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM--ALPRSLGKLTKLTNLNV 319
           I Q   +  L + +N+L  +  AI     L +L L  N L    LP  +GKLT L     
Sbjct: 265 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 324

Query: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
             N+LE +P  +  C  L  L L  N L  LP  +   TE+ VLDV  N
Sbjct: 325 ANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373



 Score =  125 bits (314), Expect = 3e-28
 Identities = 102/307 (33%), Positives = 151/307 (49%), Gaps = 18/307 (5%)

Query: 37  SLEELLLDANQLRE--LPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDI 94
           SL  ++  AN L+   +P   F+L +L  L LS N++   P E+ N   ++ L++S N I
Sbjct: 80  SLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSI 139

Query: 95  PEIPESIKFCKALEIA--DFSGNPLSRLPDGFTQLRSLAHLALND-----VSLQALPGDV 147
             IP  + F    ++   D S N L  LP    +L  L  L LN        L+ LP   
Sbjct: 140 DTIPNQL-FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA-- 196

Query: 148 GNLANLVTLELR--ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
             +  L TL LR  +    +LP SL  L  L  +DL  NDL  +P+ L  LP+LR L L 
Sbjct: 197 --MTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLS 254

Query: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL--RRLPDGIG 263
            NQ++ L   +     +  L++S N+L  LP+ +  L  L  L L+ N L    LP GIG
Sbjct: 255 SNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIG 314

Query: 264 QLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNH 323
           +L  L       N L  V E++  C  L +L+L +N L+ LP ++  LT++  L+V  N 
Sbjct: 315 KLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENP 374

Query: 324 LEALPPE 330
              +PP+
Sbjct: 375 NLVMPPK 381



 Score =  108 bits (269), Expect = 6e-23
 Identities = 99/320 (30%), Positives = 154/320 (48%), Gaps = 15/320 (4%)

Query: 87  LDVSRNDIPE--IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALP 144
           +D+S ND      PE++K   +L     +   L  LP+    L+ L HL+++  +L  L 
Sbjct: 13  VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72

Query: 145 GDVGNLANLVTLELRENLLKS--LPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
           G++ +L +L  +  R N LK+  +P  +  L  L  LDL  N L   P  L    N+  L
Sbjct: 73  GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132

Query: 203 WLDRNQLSALPPELG-NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN-----LLR 256
            L  N +  +P +L  NL  L+ LD+SENRLE LP ++  LV L  L+L+ N      LR
Sbjct: 133 NLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLR 192

Query: 257 RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTN 316
           +LP  +  L+ L  L+  Q     +  ++    NL+++ L+ N L  +P  L  L  L  
Sbjct: 193 QLP-AMTALQTLH-LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRR 250

Query: 317 LNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRL--QSLP 374
           LN+  N +  L   I   V +  L+L  N+L  LP  +   ++L  L +  N+L    LP
Sbjct: 251 LNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLP 310

Query: 375 FALTHL-NLKALWLAENQAQ 393
             +  L NL+    A N  +
Sbjct: 311 SGIGKLTNLEEFMAANNNLE 330



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 75/260 (28%), Positives = 124/260 (47%), Gaps = 15/260 (5%)

Query: 7   LWRCNRHVES------VDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
           L  C R +E+      ++  H S+  +P +++     L  L L  N+L  LP    RL++
Sbjct: 116 LTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVH 175

Query: 61  LRKLGLSDN-----EIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGN 115
           L+ L L+ N     ++++LP   A  +Q + L  ++     +P S++    L   D S N
Sbjct: 176 LQTLVLNGNPLLHAQLRQLPAMTA--LQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCN 233

Query: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK 175
            L+R+P+    L SL  L L+   +  L   +    ++ TL L  N L SLP+++  L K
Sbjct: 234 DLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSK 293

Query: 176 LEQLDLGGN--DLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLE 233
           L++L L  N  D + LP  +G L NL E     N L  +P  L    +L  L +++N L 
Sbjct: 294 LKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLV 353

Query: 234 ELPAELGGLVLLTDLLLSQN 253
            LP  +  L  +  L + +N
Sbjct: 354 TLPEAIHFLTEIEVLDVREN 373



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 1/40 (2%)

Query: 653 WAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEE 692
           W P  + EEEE++E   ++ E +E EE  AE EE   EE+
Sbjct: 941 WVP-VEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEED 979


>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
           sapiens]
          Length = 810

 Score =  121 bits (304), Expect = 5e-27
 Identities = 98/316 (31%), Positives = 160/316 (50%), Gaps = 12/316 (3%)

Query: 50  ELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE-----IPESIKFC 104
           E P   F   NLR L +   +I+ +P  + +   L EL ++ N   E     + + ++  
Sbjct: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543

Query: 105 KALEIADFSGNPLSRLPDGFTQLR-SLAHLALNDVSLQALP-GDVGNLANLVTLELRENL 162
           K L++     N LS+LP   T +   L  L++N+   + +    +  +ANL  LEL    
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602

Query: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLR 220
           L+ +P S+  L  L+++DL  N+L+ + + +    L  L  L L  N ++ +P ++GNL 
Sbjct: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662

Query: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
            L  L ++ N++E++P +L     L  L LS N L  LP  IG L+ L  L +  NR+  
Sbjct: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722

Query: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--S 338
           +   +  C  L  L L  N+L +LP  +G+LT LT + +  N LE LP E+G C  L  S
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782

Query: 339 VLSLRDNRLAVLPPEL 354
            L + ++    LPPE+
Sbjct: 783 GLVVEEDLFNTLPPEV 798



 Score =  112 bits (280), Expect = 3e-24
 Identities = 105/364 (28%), Positives = 163/364 (44%), Gaps = 35/364 (9%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           L  +P+ ++     LE L L+      +P    +L  L++L L     +   P +A   +
Sbjct: 435 LSGIPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493

Query: 84  -LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR-----LPDGFTQLRSLAHLALND 137
            L  L +   DI EIP  I   K LE    +GN  +      + DG  +L+ L  L L  
Sbjct: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553

Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
            +L  LP  V ++  +L  L +     K +   SL  +  L +L+L   DLE +P ++ +
Sbjct: 554 -NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS 612

Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
           L NL+E+ L  N L  +   +   +L RL CL +  N +  +P ++G L  L  L L++N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            + ++P  +                         C  L  L L+ N L  LP  +G L  
Sbjct: 673 KIEKIPTQLFY-----------------------CRKLRYLDLSHNNLTFLPADIGLLQN 709

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
           L NL +  N +E LPPE+  C  L  L L +N L  LP  +   T L  +++ GNRL+ L
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769

Query: 374 PFAL 377
           P  L
Sbjct: 770 PVEL 773



 Score =  104 bits (260), Expect = 6e-22
 Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 14/274 (5%)

Query: 2   LKCIPLWRCNRHVESVDKRHCSLQAVPE-------EIYRYSRSLEELLLDANQLRELPKP 54
           +K IPLW  +  ++++++ H +     E       +  R  + L+ L L +N L +LP+ 
Sbjct: 505 IKEIPLWIYS--LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQV 561

Query: 55  FFRL-LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADF 112
              + ++L+KL +++   + +    +     L EL++ R D+  IP SI     L+  D 
Sbjct: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621

Query: 113 SGNPLSRLPD--GFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
             N L  + +   F  L  L  L L    +  +P  +GNL NL  L L  N ++ +P  L
Sbjct: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681

Query: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
            +  KL  LDL  N+L  LP  +G L NL+ L +  N++  LPPEL   R+L  L +  N
Sbjct: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741

Query: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
            L+ LP+ +G L  LT + L  N L  LP  +G+
Sbjct: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775



 Score =  100 bits (248), Expect = 2e-20
 Identities = 66/199 (33%), Positives = 105/199 (52%), Gaps = 5/199 (2%)

Query: 22  CSLQAVPEEIYRYSRSLEELLLDANQLRELPK--PFFRLLNLRKLGLSDNEIQRLPPEVA 79
           C L+ +P  I+    +L+E+ L  N L+ + +   F  L  L  L L  N I  +P ++ 
Sbjct: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659

Query: 80  NFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139
           N   L  L ++RN I +IP  + +C+ L   D S N L+ LP     L++L +LA+    
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719

Query: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199
           ++ LP ++     L  L L  N+L+SLP+ +  L  L Q++L GN LE LP  LG  P L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779

Query: 200 RE--LWLDRNQLSALPPEL 216
           +   L ++ +  + LPPE+
Sbjct: 780 KRSGLVVEEDLFNTLPPEV 798


>gi|187829877 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  121 bits (304), Expect = 5e-27
 Identities = 98/316 (31%), Positives = 160/316 (50%), Gaps = 12/316 (3%)

Query: 50  ELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE-----IPESIKFC 104
           E P   F   NLR L +   +I+ +P  + +   L EL ++ N   E     + + ++  
Sbjct: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543

Query: 105 KALEIADFSGNPLSRLPDGFTQLR-SLAHLALNDVSLQALP-GDVGNLANLVTLELRENL 162
           K L++     N LS+LP   T +   L  L++N+   + +    +  +ANL  LEL    
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602

Query: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLR 220
           L+ +P S+  L  L+++DL  N+L+ + + +    L  L  L L  N ++ +P ++GNL 
Sbjct: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662

Query: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
            L  L ++ N++E++P +L     L  L LS N L  LP  IG L+ L  L +  NR+  
Sbjct: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722

Query: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--S 338
           +   +  C  L  L L  N+L +LP  +G+LT LT + +  N LE LP E+G C  L  S
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782

Query: 339 VLSLRDNRLAVLPPEL 354
            L + ++    LPPE+
Sbjct: 783 GLVVEEDLFNTLPPEV 798



 Score =  112 bits (280), Expect = 3e-24
 Identities = 105/364 (28%), Positives = 163/364 (44%), Gaps = 35/364 (9%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           L  +P+ ++     LE L L+      +P    +L  L++L L     +   P +A   +
Sbjct: 435 LSGIPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493

Query: 84  -LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR-----LPDGFTQLRSLAHLALND 137
            L  L +   DI EIP  I   K LE    +GN  +      + DG  +L+ L  L L  
Sbjct: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553

Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
            +L  LP  V ++  +L  L +     K +   SL  +  L +L+L   DLE +P ++ +
Sbjct: 554 -NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS 612

Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
           L NL+E+ L  N L  +   +   +L RL CL +  N +  +P ++G L  L  L L++N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            + ++P  +                         C  L  L L+ N L  LP  +G L  
Sbjct: 673 KIEKIPTQLFY-----------------------CRKLRYLDLSHNNLTFLPADIGLLQN 709

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
           L NL +  N +E LPPE+  C  L  L L +N L  LP  +   T L  +++ GNRL+ L
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769

Query: 374 PFAL 377
           P  L
Sbjct: 770 PVEL 773



 Score =  104 bits (260), Expect = 6e-22
 Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 14/274 (5%)

Query: 2   LKCIPLWRCNRHVESVDKRHCSLQAVPE-------EIYRYSRSLEELLLDANQLRELPKP 54
           +K IPLW  +  ++++++ H +     E       +  R  + L+ L L +N L +LP+ 
Sbjct: 505 IKEIPLWIYS--LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQV 561

Query: 55  FFRL-LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADF 112
              + ++L+KL +++   + +    +     L EL++ R D+  IP SI     L+  D 
Sbjct: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621

Query: 113 SGNPLSRLPD--GFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
             N L  + +   F  L  L  L L    +  +P  +GNL NL  L L  N ++ +P  L
Sbjct: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681

Query: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
            +  KL  LDL  N+L  LP  +G L NL+ L +  N++  LPPEL   R+L  L +  N
Sbjct: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741

Query: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
            L+ LP+ +G L  LT + L  N L  LP  +G+
Sbjct: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775



 Score =  100 bits (248), Expect = 2e-20
 Identities = 66/199 (33%), Positives = 105/199 (52%), Gaps = 5/199 (2%)

Query: 22  CSLQAVPEEIYRYSRSLEELLLDANQLRELPK--PFFRLLNLRKLGLSDNEIQRLPPEVA 79
           C L+ +P  I+    +L+E+ L  N L+ + +   F  L  L  L L  N I  +P ++ 
Sbjct: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659

Query: 80  NFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139
           N   L  L ++RN I +IP  + +C+ L   D S N L+ LP     L++L +LA+    
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719

Query: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199
           ++ LP ++     L  L L  N+L+SLP+ +  L  L Q++L GN LE LP  LG  P L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779

Query: 200 RE--LWLDRNQLSALPPEL 216
           +   L ++ +  + LPPE+
Sbjct: 780 KRSGLVVEEDLFNTLPPEV 798


>gi|187829871 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  121 bits (304), Expect = 5e-27
 Identities = 98/316 (31%), Positives = 160/316 (50%), Gaps = 12/316 (3%)

Query: 50  ELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE-----IPESIKFC 104
           E P   F   NLR L +   +I+ +P  + +   L EL ++ N   E     + + ++  
Sbjct: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543

Query: 105 KALEIADFSGNPLSRLPDGFTQLR-SLAHLALNDVSLQALP-GDVGNLANLVTLELRENL 162
           K L++     N LS+LP   T +   L  L++N+   + +    +  +ANL  LEL    
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602

Query: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLR 220
           L+ +P S+  L  L+++DL  N+L+ + + +    L  L  L L  N ++ +P ++GNL 
Sbjct: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662

Query: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
            L  L ++ N++E++P +L     L  L LS N L  LP  IG L+ L  L +  NR+  
Sbjct: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722

Query: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--S 338
           +   +  C  L  L L  N+L +LP  +G+LT LT + +  N LE LP E+G C  L  S
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782

Query: 339 VLSLRDNRLAVLPPEL 354
            L + ++    LPPE+
Sbjct: 783 GLVVEEDLFNTLPPEV 798



 Score =  112 bits (280), Expect = 3e-24
 Identities = 105/364 (28%), Positives = 163/364 (44%), Gaps = 35/364 (9%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           L  +P+ ++     LE L L+      +P    +L  L++L L     +   P +A   +
Sbjct: 435 LSGIPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493

Query: 84  -LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR-----LPDGFTQLRSLAHLALND 137
            L  L +   DI EIP  I   K LE    +GN  +      + DG  +L+ L  L L  
Sbjct: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553

Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
            +L  LP  V ++  +L  L +     K +   SL  +  L +L+L   DLE +P ++ +
Sbjct: 554 -NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS 612

Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
           L NL+E+ L  N L  +   +   +L RL CL +  N +  +P ++G L  L  L L++N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            + ++P  +                         C  L  L L+ N L  LP  +G L  
Sbjct: 673 KIEKIPTQLFY-----------------------CRKLRYLDLSHNNLTFLPADIGLLQN 709

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
           L NL +  N +E LPPE+  C  L  L L +N L  LP  +   T L  +++ GNRL+ L
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769

Query: 374 PFAL 377
           P  L
Sbjct: 770 PVEL 773



 Score =  104 bits (260), Expect = 6e-22
 Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 14/274 (5%)

Query: 2   LKCIPLWRCNRHVESVDKRHCSLQAVPE-------EIYRYSRSLEELLLDANQLRELPKP 54
           +K IPLW  +  ++++++ H +     E       +  R  + L+ L L +N L +LP+ 
Sbjct: 505 IKEIPLWIYS--LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQV 561

Query: 55  FFRL-LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADF 112
              + ++L+KL +++   + +    +     L EL++ R D+  IP SI     L+  D 
Sbjct: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621

Query: 113 SGNPLSRLPD--GFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
             N L  + +   F  L  L  L L    +  +P  +GNL NL  L L  N ++ +P  L
Sbjct: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681

Query: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
            +  KL  LDL  N+L  LP  +G L NL+ L +  N++  LPPEL   R+L  L +  N
Sbjct: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741

Query: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
            L+ LP+ +G L  LT + L  N L  LP  +G+
Sbjct: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775



 Score =  100 bits (248), Expect = 2e-20
 Identities = 66/199 (33%), Positives = 105/199 (52%), Gaps = 5/199 (2%)

Query: 22  CSLQAVPEEIYRYSRSLEELLLDANQLRELPK--PFFRLLNLRKLGLSDNEIQRLPPEVA 79
           C L+ +P  I+    +L+E+ L  N L+ + +   F  L  L  L L  N I  +P ++ 
Sbjct: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659

Query: 80  NFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139
           N   L  L ++RN I +IP  + +C+ L   D S N L+ LP     L++L +LA+    
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719

Query: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199
           ++ LP ++     L  L L  N+L+SLP+ +  L  L Q++L GN LE LP  LG  P L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779

Query: 200 RE--LWLDRNQLSALPPEL 216
           +   L ++ +  + LPPE+
Sbjct: 780 KRSGLVVEEDLFNTLPPEV 798


>gi|197333692 leucine rich repeat containing 8 family, member B
           [Homo sapiens]
          Length = 803

 Score =  119 bits (298), Expect = 2e-26
 Identities = 106/346 (30%), Positives = 165/346 (47%), Gaps = 43/346 (12%)

Query: 21  HCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
           H SL      +     +L+ L L   ++ ++P+  F L NL++L LS   +    PE  +
Sbjct: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527

Query: 81  FMQL-----------VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
            MQL           + L  S + IP++   +         D  G+ L  L +   ++ +
Sbjct: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586

Query: 130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF--LVKLEQLDLGGNDLE 187
           L  L L    L+ +P  + +L NL  L+LREN LK++   +SF  L  L  L L  N++ 
Sbjct: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646

Query: 188 VLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTD 247
            +P  +GAL NL +L LD N +  LP +L    +L  LD+S N L  +P E+  L  L  
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706

Query: 248 LLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRS 307
             ++ N +  LPDG+ Q                       C+ L  L+L +N LM L   
Sbjct: 707 FAVTNNNIEMLPDGLFQ-----------------------CKKLQCLLLGKNSLMNLSPH 743

Query: 308 LGKLTKLTNLNVDRNHLEALPPEIGGCVAL--SVLSLRDNRLAVLP 351
           +G+L+ LT+L +  N+LE LPPE+ GC +L  + L + +N L  LP
Sbjct: 744 VGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789



 Score =  105 bits (262), Expect = 4e-22
 Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 14/367 (3%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           L  +P+ ++  +  +E L L+     +LP    +L+NL++L +  + +    P +A   +
Sbjct: 429 LNGLPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE 487

Query: 84  LVE-LDVSRNDIPEIPESIKFCKALEIADFSG----NPLSRLP-DGFTQLRSLAHLALND 137
            ++ L +   ++ +IP  +   K L+    SG      LS +  +GF  L++L  L L  
Sbjct: 488 NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS 547

Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGA 195
            SL  +P  V +L  +L  L L     K +  + L  +V L+ L+L   DLE +P ++ +
Sbjct: 548 -SLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS 606

Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
           L NL EL L  N L  +   +   +L+ L CL +  N +  +PA++G L  L  L L  N
Sbjct: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            +  LP  +    +L  L +  N L  + E I    NL    +T N +  LP  L +  K
Sbjct: 667 NIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKK 726

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL--AHTTELHVLDVAGNRLQ 371
           L  L + +N L  L P +G    L+ L L  N L  LPPEL    + + + L V  N L 
Sbjct: 727 LQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786

Query: 372 SLPFALT 378
           +LP  +T
Sbjct: 787 TLPLPVT 793



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 91/323 (28%), Positives = 142/323 (43%), Gaps = 26/323 (8%)

Query: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175
           L+ LPD   +L  +  L+L  +    LP  V  L NL  L +  + L     +L+FL + 
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488

Query: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
           L+ L L   ++  +P  +  L NL+EL+L       LP +L  ++     D+   R   L
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYL 545

Query: 236 PAELGGLV-LLTDLLLSQNLLRRLPDG-----------IGQLKQLSILKVDQNRLCEVTE 283
            + L  +  ++TDLL S   L    +G           +  LK L ++  D  R   +  
Sbjct: 546 KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLER---IPH 602

Query: 284 AIGDCENLSELILTENLLMALPR--SLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
           +I    NL EL L EN L  +    S   L  L+ L +  N++  +P +IG    L  LS
Sbjct: 603 SIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLS 662

Query: 342 LRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTE 401
           L  N +  LP +L   T+LH LD++ N L  +P  + +L+    +   N    ML     
Sbjct: 663 LDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEML----- 717

Query: 402 DDARTGEKVLTCYLLPQQPPLSL 424
            D     K L C LL +   ++L
Sbjct: 718 PDGLFQCKKLQCLLLGKNSLMNL 740


>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
           sapiens]
          Length = 803

 Score =  119 bits (298), Expect = 2e-26
 Identities = 106/346 (30%), Positives = 165/346 (47%), Gaps = 43/346 (12%)

Query: 21  HCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
           H SL      +     +L+ L L   ++ ++P+  F L NL++L LS   +    PE  +
Sbjct: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527

Query: 81  FMQL-----------VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
            MQL           + L  S + IP++   +         D  G+ L  L +   ++ +
Sbjct: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586

Query: 130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF--LVKLEQLDLGGNDLE 187
           L  L L    L+ +P  + +L NL  L+LREN LK++   +SF  L  L  L L  N++ 
Sbjct: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646

Query: 188 VLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTD 247
            +P  +GAL NL +L LD N +  LP +L    +L  LD+S N L  +P E+  L  L  
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706

Query: 248 LLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRS 307
             ++ N +  LPDG+ Q                       C+ L  L+L +N LM L   
Sbjct: 707 FAVTNNNIEMLPDGLFQ-----------------------CKKLQCLLLGKNSLMNLSPH 743

Query: 308 LGKLTKLTNLNVDRNHLEALPPEIGGCVAL--SVLSLRDNRLAVLP 351
           +G+L+ LT+L +  N+LE LPPE+ GC +L  + L + +N L  LP
Sbjct: 744 VGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789



 Score =  105 bits (262), Expect = 4e-22
 Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 14/367 (3%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           L  +P+ ++  +  +E L L+     +LP    +L+NL++L +  + +    P +A   +
Sbjct: 429 LNGLPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE 487

Query: 84  LVE-LDVSRNDIPEIPESIKFCKALEIADFSG----NPLSRLP-DGFTQLRSLAHLALND 137
            ++ L +   ++ +IP  +   K L+    SG      LS +  +GF  L++L  L L  
Sbjct: 488 NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS 547

Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGA 195
            SL  +P  V +L  +L  L L     K +  + L  +V L+ L+L   DLE +P ++ +
Sbjct: 548 -SLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS 606

Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
           L NL EL L  N L  +   +   +L+ L CL +  N +  +PA++G L  L  L L  N
Sbjct: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666

Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
            +  LP  +    +L  L +  N L  + E I    NL    +T N +  LP  L +  K
Sbjct: 667 NIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKK 726

Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL--AHTTELHVLDVAGNRLQ 371
           L  L + +N L  L P +G    L+ L L  N L  LPPEL    + + + L V  N L 
Sbjct: 727 LQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786

Query: 372 SLPFALT 378
           +LP  +T
Sbjct: 787 TLPLPVT 793



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 91/323 (28%), Positives = 142/323 (43%), Gaps = 26/323 (8%)

Query: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175
           L+ LPD   +L  +  L+L  +    LP  V  L NL  L +  + L     +L+FL + 
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488

Query: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
           L+ L L   ++  +P  +  L NL+EL+L       LP +L  ++     D+   R   L
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYL 545

Query: 236 PAELGGLV-LLTDLLLSQNLLRRLPDG-----------IGQLKQLSILKVDQNRLCEVTE 283
            + L  +  ++TDLL S   L    +G           +  LK L ++  D  R   +  
Sbjct: 546 KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLER---IPH 602

Query: 284 AIGDCENLSELILTENLLMALPR--SLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
           +I    NL EL L EN L  +    S   L  L+ L +  N++  +P +IG    L  LS
Sbjct: 603 SIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLS 662

Query: 342 LRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTE 401
           L  N +  LP +L   T+LH LD++ N L  +P  + +L+    +   N    ML     
Sbjct: 663 LDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEML----- 717

Query: 402 DDARTGEKVLTCYLLPQQPPLSL 424
            D     K L C LL +   ++L
Sbjct: 718 PDGLFQCKKLQCLLLGKNSLMNL 740


>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
          Length = 347

 Score =  117 bits (292), Expect = 1e-25
 Identities = 75/228 (32%), Positives = 116/228 (50%), Gaps = 4/228 (1%)

Query: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
           + L G  +  +P  LG LP L+ L L  N +  + PEL NL +L  L++  N LEE+P E
Sbjct: 19  ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78

Query: 239 LGGLVLLTDLLLSQNLLRRL-PDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILT 297
           +  L  L +L LS N + R  P     L+ L +L ++ N L ++ + +   ++L+ + + 
Sbjct: 79  MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138

Query: 298 ENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHT 357
            N L ++PR L  L  L  L ++ N L  +P EI     L  L L  N + VLP EL   
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198

Query: 358 TELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ---AQPMLRFQTED 402
            +L +LD+AGN +Q  P     L L+  +   N     QP++  Q E+
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQEN 246



 Score =  111 bits (278), Expect = 5e-24
 Identities = 75/247 (30%), Positives = 128/247 (51%), Gaps = 8/247 (3%)

Query: 41  LLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPES 100
           + L+  ++ ++P    +L  L+ L L +N I ++ PE+ N  QL  L++  N + E+PE 
Sbjct: 19  ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78

Query: 101 IKFCKALEIADFSGNPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELR 159
           +K+  +L+    SGN + R   G    L++L  L LN+  L  LP +V  L +L  + + 
Sbjct: 79  MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138

Query: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
            N L S+P  L FL  L +L L  N L  +P+ +  L  L++L L RN +  LP EL +L
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198

Query: 220 RRLVCLDVSENRLEELPAELGGLVLL------TDLLLSQNLLRRLPDGIGQLKQLSILKV 273
           ++L  LD++ N ++  P+    L L         L L Q ++    + +  L++++   V
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFV 258

Query: 274 DQNRLCE 280
             N+L E
Sbjct: 259 -MNQLAE 264



 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 68/228 (29%), Positives = 110/228 (48%), Gaps = 2/228 (0%)

Query: 105 KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLK 164
           K  +I   +G  ++++P    +L  L  L L +  +  +  ++ NL  L TL L  NLL+
Sbjct: 14  KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73

Query: 165 SLPASLSFLVKLEQLDLGGNDL-EVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLV 223
            +P  + +L  L+ L L GN +    P     L NL  L L+ N L+ LP E+  L+ L 
Sbjct: 74  EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133

Query: 224 CLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
            + ++ N+L  +P EL  L  L +L L+ N L  +P+ I  LK+L  L + +N +  + E
Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193

Query: 284 AIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
            + D + L  L +  N++   P     L KL     + N L    P I
Sbjct: 194 ELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVI 240



 Score = 84.3 bits (207), Expect = 9e-16
 Identities = 62/208 (29%), Positives = 99/208 (47%), Gaps = 1/208 (0%)

Query: 60  NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 119
           N + + L+  ++ ++P  +     L  L +  N IP++   +     L   +   N L  
Sbjct: 15  NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74

Query: 120 LPDGFTQLRSLAHLALNDVSL-QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQ 178
           +P+    L SL +L L+   + +  PG    L NL+ L L  N L  LP  +S L  L  
Sbjct: 75  VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134

Query: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
           + +  N L  +P  L  L NL EL L+ NQL  +P E+  L++L  L ++ N +  LP E
Sbjct: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194

Query: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLK 266
           L  L  L  L ++ N+++  P G   LK
Sbjct: 195 LCDLKKLRILDIAGNIIQIFPSGFQDLK 222



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 35/105 (33%), Positives = 60/105 (57%), Gaps = 1/105 (0%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           L  +P+E+ R  +SL  + ++ NQL  +P+    L NL +L L+ N++  +P E+    +
Sbjct: 119 LTQLPQEVSRL-KSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKK 177

Query: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLR 128
           L +L ++RN+I  +PE +   K L I D +GN +   P GF  L+
Sbjct: 178 LQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 44/151 (29%), Positives = 68/151 (45%), Gaps = 25/151 (16%)

Query: 266 KQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLE 325
           K   I+ ++  ++ ++  A+G    L  L+L  NL+  +   L  LT+LT LN+  N LE
Sbjct: 14  KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73

Query: 326 ALPPEI---------------------GGCVALS---VLSLRDNRLAVLPPELAHTTELH 361
            +P E+                     G C  L    +L+L +N L  LP E++    L 
Sbjct: 74  EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133

Query: 362 VLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391
            + +  N+L S+P  L  L NL  L L  NQ
Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQ 164



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 26/88 (29%), Positives = 46/88 (52%)

Query: 283 EAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSL 342
           +A+   +N   + L    +  +P +LGKL  L  L +  N +  + PE+     L+ L+L
Sbjct: 8   KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNL 67

Query: 343 RDNRLAVLPPELAHTTELHVLDVAGNRL 370
            +N L  +P E+ + T L  L ++GNR+
Sbjct: 68  GNNLLEEVPEEMKYLTSLKNLHLSGNRI 95



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 2/94 (2%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
           L ++P E+  +  +L EL L+ NQL  +P+    L  L+KL L+ N I  LP E+ +  +
Sbjct: 142 LASIPRELC-FLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKK 200

Query: 84  LVELDVSRNDIPEIPESIKFCKALEIADFSGNPL 117
           L  LD++ N I   P   +  K  E     GNPL
Sbjct: 201 LRILDIAGNIIQIFPSGFQDLKLREFY-CEGNPL 233


>gi|61742786 leucine rich repeat and death domain containing protein
           isoform 3 [Homo sapiens]
          Length = 893

 Score =  116 bits (290), Expect = 2e-25
 Identities = 88/225 (39%), Positives = 113/225 (50%), Gaps = 9/225 (4%)

Query: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL--ELRENL-------LKSL 166
           PL  L   F +L +     L + +L  LP  +  L +LV    + R+ L       L +L
Sbjct: 58  PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117

Query: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
           PA LS L  L  LDL  N LE LP  +  +  L  L L  N LS LP  LG L  L  L 
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177

Query: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIG 286
           V+ NRL+ LP  LG L  L  L LSQNLL  LP  IG L  L  L +  NRL  +  ++ 
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237

Query: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
              +L  L+L  NLL ++P  L +L  LT L++  N L  LPPE+
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score =  115 bits (287), Expect = 5e-25
 Identities = 100/263 (38%), Positives = 127/263 (48%), Gaps = 20/263 (7%)

Query: 114 GNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171
           GN LS    P G  QL    HL +    LQ L  +   L+     +L E  L  LP SLS
Sbjct: 35  GNRLSLDLYPGGCQQL---LHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLS 90

Query: 172 FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR 231
            L     L L G       DTLGA          R  L+ LP  L  L  L  LD+S N 
Sbjct: 91  CL---RSLVLKGGQRR---DTLGACL--------RGALTNLPAGLSGLAHLAHLDLSFNS 136

Query: 232 LEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENL 291
           LE LPA +  +  L  LLLS N L  LP+ +G L  L+ L V  NRL  +  A+G    L
Sbjct: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196

Query: 292 SELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351
             L L++NLL  LP  +G L  L  LN+  N L++LP  + G  +L +L L  N LA +P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256

Query: 352 PELAHTTELHVLDVAGNRLQSLP 374
            +LA    L  LD+  N+L+ LP
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLP 279



 Score =  106 bits (265), Expect = 2e-22
 Identities = 69/171 (40%), Positives = 95/171 (55%)

Query: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176
           L+ LP G + L  LAHL L+  SL+ LP  V  +  L  L L  N L  LP +L  L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
             L +  N L+ LP  LGAL  L+ L L +N L  LPPE+G L  L+ L+++ NRL+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
           A L GL  L  L+L  NLL  +P  + +L  L+ L +  N+L ++   + D
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284



 Score =  103 bits (258), Expect = 1e-21
 Identities = 95/274 (34%), Positives = 128/274 (46%), Gaps = 29/274 (10%)

Query: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DL 186
           R+L  L  N +SL   PG    L +L   +  +            L+++E L L  + D 
Sbjct: 28  RALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ------------LLQVEFLRLSTHEDP 75

Query: 187 EVLPDTLGALPN----LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
           ++L  TL  LP     LR L L            G  RR          L  LPA L GL
Sbjct: 76  QLLEATLAQLPQSLSCLRSLVLK-----------GGQRRDTLGACLRGALTNLPAGLSGL 124

Query: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
             L  L LS N L  LP  + Q++ L  L +  N L E+ EA+G    L+ L +T N L 
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184

Query: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362
            LP +LG L+ L  L++ +N L+ LPPEIGG  +L  L+L  NRL  LP  LA    L +
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244

Query: 363 LDVAGNRLQSLPFALTHLN-LKALWLAENQAQPM 395
           L +  N L S+P  L  L  L  L L +NQ + +
Sbjct: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDL 278



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 10/225 (4%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE---------IQRL 74
           LQ +  E  R S   +  LL+A  L +LP+    L +L   G    +         +  L
Sbjct: 59  LQLLQVEFLRLSTHEDPQLLEAT-LAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117

Query: 75  PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134
           P  ++    L  LD+S N +  +P  +   + L     S N LS LP+    L +L  L 
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177

Query: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
           +    LQ LP  +G L+ L  L+L +NLL +LP  +  L  L +L+L  N L+ LP +L 
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237

Query: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239
            L +LR L L  N L+++P +L  L  L  LD+ +N+L +LP EL
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 77/221 (34%), Positives = 103/221 (46%), Gaps = 9/221 (4%)

Query: 48  LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND---------IPEIP 98
           L+ L   F RL       L +  + +LP  ++    LV     R D         +  +P
Sbjct: 59  LQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLP 118

Query: 99  ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLEL 158
             +     L   D S N L  LP    Q+R L  L L+   L  LP  +G L  L  L +
Sbjct: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178

Query: 159 RENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218
             N L++LP +L  L  L++LDL  N L+ LP  +G L +L EL L  N+L +LP  L  
Sbjct: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238

Query: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
           LR L  L +  N L  +PA+L  L LLT L L  N LR LP
Sbjct: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279



 Score = 77.8 bits (190), Expect = 8e-14
 Identities = 62/178 (34%), Positives = 80/178 (44%), Gaps = 3/178 (1%)

Query: 38  LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
           L  L L  N L  LP    ++  L  L LS N +  LP  +     L  L V+ N +  +
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186

Query: 98  PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLE 157
           P ++     L+  D S N L  LP     L SL  L L    LQ+LP  +  L +L  L 
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246

Query: 158 LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
           L  NLL S+PA L+ L  L +LDL  N L  LP  L   P +R   L  N L    P+
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGNPLGEASPD 301


>gi|61742784 leucine rich repeat and death domain containing protein
           isoform 1 [Homo sapiens]
          Length = 910

 Score =  116 bits (290), Expect = 2e-25
 Identities = 88/225 (39%), Positives = 113/225 (50%), Gaps = 9/225 (4%)

Query: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL--ELRENL-------LKSL 166
           PL  L   F +L +     L + +L  LP  +  L +LV    + R+ L       L +L
Sbjct: 58  PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117

Query: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
           PA LS L  L  LDL  N LE LP  +  +  L  L L  N LS LP  LG L  L  L 
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177

Query: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIG 286
           V+ NRL+ LP  LG L  L  L LSQNLL  LP  IG L  L  L +  NRL  +  ++ 
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237

Query: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
              +L  L+L  NLL ++P  L +L  LT L++  N L  LPPE+
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score =  115 bits (287), Expect = 5e-25
 Identities = 100/263 (38%), Positives = 127/263 (48%), Gaps = 20/263 (7%)

Query: 114 GNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171
           GN LS    P G  QL    HL +    LQ L  +   L+     +L E  L  LP SLS
Sbjct: 35  GNRLSLDLYPGGCQQL---LHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLS 90

Query: 172 FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR 231
            L     L L G       DTLGA          R  L+ LP  L  L  L  LD+S N 
Sbjct: 91  CL---RSLVLKGGQRR---DTLGACL--------RGALTNLPAGLSGLAHLAHLDLSFNS 136

Query: 232 LEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENL 291
           LE LPA +  +  L  LLLS N L  LP+ +G L  L+ L V  NRL  +  A+G    L
Sbjct: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196

Query: 292 SELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351
             L L++NLL  LP  +G L  L  LN+  N L++LP  + G  +L +L L  N LA +P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256

Query: 352 PELAHTTELHVLDVAGNRLQSLP 374
            +LA    L  LD+  N+L+ LP
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLP 279



 Score =  106 bits (265), Expect = 2e-22
 Identities = 69/171 (40%), Positives = 95/171 (55%)

Query: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176
           L+ LP G + L  LAHL L+  SL+ LP  V  +  L  L L  N L  LP +L  L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
             L +  N L+ LP  LGAL  L+ L L +N L  LPPE+G L  L+ L+++ NRL+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
           A L GL  L  L+L  NLL  +P  + +L  L+ L +  N+L ++   + D
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284



 Score =  103 bits (258), Expect = 1e-21
 Identities = 95/274 (34%), Positives = 128/274 (46%), Gaps = 29/274 (10%)

Query: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DL 186
           R+L  L  N +SL   PG    L +L   +  +            L+++E L L  + D 
Sbjct: 28  RALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ------------LLQVEFLRLSTHEDP 75

Query: 187 EVLPDTLGALPN----LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
           ++L  TL  LP     LR L L            G  RR          L  LPA L GL
Sbjct: 76  QLLEATLAQLPQSLSCLRSLVLK-----------GGQRRDTLGACLRGALTNLPAGLSGL 124

Query: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
             L  L LS N L  LP  + Q++ L  L +  N L E+ EA+G    L+ L +T N L 
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184

Query: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362
            LP +LG L+ L  L++ +N L+ LPPEIGG  +L  L+L  NRL  LP  LA    L +
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244

Query: 363 LDVAGNRLQSLPFALTHLN-LKALWLAENQAQPM 395
           L +  N L S+P  L  L  L  L L +NQ + +
Sbjct: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDL 278



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 10/225 (4%)

Query: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE---------IQRL 74
           LQ +  E  R S   +  LL+A  L +LP+    L +L   G    +         +  L
Sbjct: 59  LQLLQVEFLRLSTHEDPQLLEAT-LAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117

Query: 75  PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134
           P  ++    L  LD+S N +  +P  +   + L     S N LS LP+    L +L  L 
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177

Query: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
           +    LQ LP  +G L+ L  L+L +NLL +LP  +  L  L +L+L  N L+ LP +L 
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237

Query: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239
            L +LR L L  N L+++P +L  L  L  LD+ +N+L +LP EL
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 77/221 (34%), Positives = 103/221 (46%), Gaps = 9/221 (4%)

Query: 48  LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND---------IPEIP 98
           L+ L   F RL       L +  + +LP  ++    LV     R D         +  +P
Sbjct: 59  LQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLP 118

Query: 99  ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLEL 158
             +     L   D S N L  LP    Q+R L  L L+   L  LP  +G L  L  L +
Sbjct: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178

Query: 159 RENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218
             N L++LP +L  L  L++LDL  N L+ LP  +G L +L EL L  N+L +LP  L  
Sbjct: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238

Query: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
           LR L  L +  N L  +PA+L  L LLT L L  N LR LP
Sbjct: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279



 Score = 77.8 bits (190), Expect = 8e-14
 Identities = 62/178 (34%), Positives = 80/178 (44%), Gaps = 3/178 (1%)

Query: 38  LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
           L  L L  N L  LP    ++  L  L LS N +  LP  +     L  L V+ N +  +
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186

Query: 98  PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLE 157
           P ++     L+  D S N L  LP     L SL  L L    LQ+LP  +  L +L  L 
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246

Query: 158 LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
           L  NLL S+PA L+ L  L +LDL  N L  LP  L   P +R   L  N L    P+
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGNPLGEASPD 301


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.133    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,909,525
Number of Sequences: 37866
Number of extensions: 4716220
Number of successful extensions: 77809
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 907
Number of HSP's successfully gapped in prelim test: 1510
Number of HSP's that attempted gapping in prelim test: 34724
Number of HSP's gapped (non-prelim): 27775
length of query: 1630
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1514
effective length of database: 13,855,062
effective search space: 20976563868
effective search space used: 20976563868
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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