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Search of human proteins with 45827729
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45827729 scribble isoform b [Homo sapiens]
(1630 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45827729 scribble isoform b [Homo sapiens] 3224 0.0
gi|45827731 scribble isoform a [Homo sapiens] 3211 0.0
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 640 0.0
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 389 e-107
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 389 e-107
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 387 e-107
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 193 1e-48
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 164 6e-40
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 164 6e-40
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 161 5e-39
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 161 5e-39
gi|238908508 leucine-rich repeat and death domain-containing pro... 156 2e-37
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 155 3e-37
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 152 3e-36
gi|148746189 multiple PDZ domain protein [Homo sapiens] 150 1e-35
gi|112382257 InaD-like [Homo sapiens] 149 2e-35
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 148 5e-35
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 147 8e-35
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 145 3e-34
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 145 3e-34
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 138 5e-32
gi|4503743 flightless I homolog [Homo sapiens] 126 2e-28
gi|62241040 leucine rich repeat containing 8 family, member A [H... 121 5e-27
gi|187829877 leucine rich repeat containing 8 family, member A [... 121 5e-27
gi|187829871 leucine rich repeat containing 8 family, member A [... 121 5e-27
gi|197333692 leucine rich repeat containing 8 family, member B [... 119 2e-26
gi|21245134 leucine rich repeat containing 8 family, member B [H... 119 2e-26
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 117 1e-25
gi|61742786 leucine rich repeat and death domain containing prot... 116 2e-25
gi|61742784 leucine rich repeat and death domain containing prot... 116 2e-25
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 3224 bits (8360), Expect = 0.0
Identities = 1630/1630 (100%), Positives = 1630/1630 (100%)
Query: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN
Sbjct: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
Query: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL
Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
Query: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD
Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
Query: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG
Sbjct: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP
Sbjct: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
Query: 421 PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE 480
PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE
Sbjct: 421 PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE 480
Query: 481 LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS 540
LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS
Sbjct: 481 LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS 540
Query: 541 AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ 600
AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ
Sbjct: 541 AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ 600
Query: 601 RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE 660
RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE
Sbjct: 601 RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE 660
Query: 661 EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA
Sbjct: 661 EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
Query: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
Query: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
Query: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG
Sbjct: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960
GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960
Query: 961 HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG 1020
HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG
Sbjct: 961 HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG 1020
Query: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080
GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR
Sbjct: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080
Query: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140
PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS
Sbjct: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140
Query: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL 1200
PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL
Sbjct: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL 1200
Query: 1201 EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG 1260
EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG
Sbjct: 1201 EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG 1260
Query: 1261 LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA 1320
LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA
Sbjct: 1261 LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA 1320
Query: 1321 YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV 1380
YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV
Sbjct: 1321 YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV 1380
Query: 1381 GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP 1440
GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP
Sbjct: 1381 GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP 1440
Query: 1441 TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL 1500
TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL
Sbjct: 1441 TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL 1500
Query: 1501 WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST 1560
WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST
Sbjct: 1501 WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST 1560
Query: 1561 SPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRP 1620
SPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRP
Sbjct: 1561 SPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRP 1620
Query: 1621 GRRGLGPVPS 1630
GRRGLGPVPS
Sbjct: 1621 GRRGLGPVPS 1630
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 3211 bits (8324), Expect = 0.0
Identities = 1630/1655 (98%), Positives = 1630/1655 (98%), Gaps = 25/1655 (1%)
Query: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN
Sbjct: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
Query: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL
Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
Query: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD
Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
Query: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG
Sbjct: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP
Sbjct: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
Query: 421 PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE 480
PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE
Sbjct: 421 PLSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSE 480
Query: 481 LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS 540
LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS
Sbjct: 481 LKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPS 540
Query: 541 AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ 600
AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ
Sbjct: 541 AEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQ 600
Query: 601 RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE 660
RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE
Sbjct: 601 RLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKE 660
Query: 661 EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA
Sbjct: 661 EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
Query: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL
Sbjct: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKL 780
Query: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
Query: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG
Sbjct: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960
GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLP 960
Query: 961 HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG 1020
HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG
Sbjct: 961 HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG 1020
Query: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080
GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR
Sbjct: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080
Query: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140
PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS
Sbjct: 1081 PCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVS 1140
Query: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL 1200
PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL
Sbjct: 1141 PTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAAL 1200
Query: 1201 EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG 1260
EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG
Sbjct: 1201 EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRG 1260
Query: 1261 LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA 1320
LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA
Sbjct: 1261 LQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQA 1320
Query: 1321 YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV 1380
YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV
Sbjct: 1321 YRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLV 1380
Query: 1381 GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP 1440
GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP
Sbjct: 1381 GADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSP 1440
Query: 1441 TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL 1500
TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL
Sbjct: 1441 TSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRAL 1500
Query: 1501 WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST 1560
WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST
Sbjct: 1501 WRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTST 1560
Query: 1561 SPGRL-------------------------SPDFAEELRSLEPSPSPGPQEEDGEVALVL 1595
SPGRL SPDFAEELRSLEPSPSPGPQEEDGEVALVL
Sbjct: 1561 SPGRLPLSGKKFDYRAFAALPSSRPVYDIQSPDFAEELRSLEPSPSPGPQEEDGEVALVL 1620
Query: 1596 LGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS 1630
LGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS
Sbjct: 1621 LGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS 1655
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 640 bits (1652), Expect = 0.0
Identities = 322/504 (63%), Positives = 404/504 (80%), Gaps = 15/504 (2%)
Query: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
M CIPLWRCNRHVES+DKRHCSL VPEEIYRY+RSLEELLLDANQLRELP+ FF+L+
Sbjct: 1 MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
Query: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
LRKLGLSDNEIQRLPPE+ANFMQLVELDVSRN+IPEIPESI FCKAL++ADFSGNPL+RL
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
Query: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
P+ F +L++L L++ND+SLQ+LP ++GNL NL +LELRENLL LP SL+ L +LE+LD
Sbjct: 121 PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180
Query: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
LG N++ LP+++GAL +L++LWLD NQLS LP E+GNL+ L+CLDVSENRLE LP E+
Sbjct: 181 LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS 240
Query: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
GL LTDL++SQNLL +PDGIG+LK+LSILKVDQNRL ++ EA+G+CE+L+EL+LTEN
Sbjct: 241 GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ 300
Query: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
L+ LP+S+GKL KL+NLN DRN L +LP EIGGC +L+V +RDNRL +P E++ TEL
Sbjct: 301 LLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360
Query: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
HVLDVAGNRL LP +LT L LKALWL++NQ+QP+L FQT+ D TGEK+LTC LLPQ P
Sbjct: 361 HVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLP 420
Query: 421 --PLSLEDAGQQGSL--------SETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGL 470
P E+ + G+L E W++ +RVS I+F+E ++ +E E R L
Sbjct: 421 SEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVE-----DEKDEEDNETRTL 475
Query: 471 QRRATPHPSELKVMKRSIEGRRSE 494
RRATPHP ELK MK+++E R++
Sbjct: 476 LRRATPHPGELKHMKKTVENLRND 499
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 389 bits (998), Expect = e-107
Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%)
Query: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
V ++D HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK F +L KL L DN++
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
LP +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
LND L+ LP + G L L LELREN LK LP +++ L +LE+LDLG N+ +P+ L
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
L L+E W+D N+L+ +P +G+L++L LDVS+N +E + + L DLLLS N
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
L++LP+ IG LK ++ LK+D+N+L + ++IG ++ EL + N + ALP S+G+LT
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
L D N+L+ LPPEIG ++VL L N+L LP E+ +L V++++ NRL++L
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
Query: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428
PF+ T L L A+WL++NQ++P++ Q E D+ T + VLT Y+ PQQP ED +
Sbjct: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441
Query: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488
+ W + R V + D+D EA + L+R TP+P ELK M +++
Sbjct: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498
Query: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543
+ R + DSG L P E+++ ++ + G+ SE + S V E E
Sbjct: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558
Query: 544 QGGSQQEATTAGG 556
Q S+ EA + G
Sbjct: 559 QKISEPEAEISPG 571
Score = 64.7 bits (156), Expect = 7e-10
Identities = 50/188 (26%), Positives = 89/188 (47%), Gaps = 12/188 (6%)
Query: 632 MQPDGEGPVAPGGWH-NGPHAPWAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTE 690
M P + P++ + +GP+A R Q E + + +R +
Sbjct: 1119 MMPGSQRPLSARTYSIDGPNAS---RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNA 1175
Query: 691 EEDKEGAVVSAPSVKGVSFDQANNLL--IEPARIEEEELTLTILRQTGGLGISIAGGKGS 748
E +++ P V D +L IE ++E+ + + + LG SI+GG G
Sbjct: 1176 RVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKIRVRV---EKDPELGFSISGGVGG 1232
Query: 749 --TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTA 806
P++ DD+GIF++RV EGPA++ ++ GDK+++ NG + EH +AV L+
Sbjct: 1233 RGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNT 1291
Query: 807 VQMRVWRE 814
V++ + RE
Sbjct: 1292 VELIIVRE 1299
Score = 60.8 bits (146), Expect = 1e-08
Identities = 32/86 (37%), Positives = 54/86 (62%), Gaps = 5/86 (5%)
Query: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162
++K P LG SI GG G GNP P D+GIF+++V P G A + L+ G ++++ N
Sbjct: 1216 VEKDP--ELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANG 1270
Query: 1163 QSLLGLTHGEAVQLLRSVGDTLTVLV 1188
S + + HG+AV LL++ +T+ +++
Sbjct: 1271 YSFINIEHGQAVSLLKTFQNTVELII 1296
Score = 60.1 bits (144), Expect = 2e-08
Identities = 34/80 (42%), Positives = 45/80 (56%), Gaps = 4/80 (5%)
Query: 872 LGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD 929
LGFSI+GG G P+R D GIFV+R+ G A + LQ GD+++ NG H
Sbjct: 1222 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKIIQANGYSFINIEHG 1279
Query: 930 HAVSLLTAASPTIALLLERE 949
AVSLL T+ L++ RE
Sbjct: 1280 QAVSLLKTFQNTVELIIVRE 1299
Score = 48.9 bits (115), Expect = 4e-05
Identities = 37/118 (31%), Positives = 57/118 (48%), Gaps = 3/118 (2%)
Query: 962 SSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGP-LGLSIVG 1020
S P A V + PG +P + +E +E+IR+ P LG SI G
Sbjct: 1170 SKRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAK-KLEKIRVRVEKDPELGFSISG 1228
Query: 1021 GSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL 1078
G +PF + G+F+++V P G A++ L+ GD+I+ NG + H +AVS L
Sbjct: 1229 GVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQAVSLL 1285
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 389 bits (998), Expect = e-107
Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%)
Query: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
V ++D HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK F +L KL L DN++
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
LP +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
LND L+ LP + G L L LELREN LK LP +++ L +LE+LDLG N+ +P+ L
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
L L+E W+D N+L+ +P +G+L++L LDVS+N +E + + L DLLLS N
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
L++LP+ IG LK ++ LK+D+N+L + ++IG ++ EL + N + ALP S+G+LT
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
L D N+L+ LPPEIG ++VL L N+L LP E+ +L V++++ NRL++L
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
Query: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428
PF+ T L L A+WL++NQ++P++ Q E D+ T + VLT Y+ PQQP ED +
Sbjct: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441
Query: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488
+ W + R V + D+D EA + L+R TP+P ELK M +++
Sbjct: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498
Query: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543
+ R + DSG L P E+++ ++ + G+ SE + S V E E
Sbjct: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558
Query: 544 QGGSQQEATTAGG 556
Q S+ EA + G
Sbjct: 559 QKISEPEAEISPG 571
Score = 63.2 bits (152), Expect = 2e-09
Identities = 32/79 (40%), Positives = 51/79 (64%), Gaps = 3/79 (3%)
Query: 738 LGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHE 795
LG SI+GG G P++ DD+GIF++RV EGPA++ ++ GDK+++ NG + EH +
Sbjct: 1291 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQ 1349
Query: 796 AVEALRGAGTAVQMRVWRE 814
AV L+ V++ + RE
Sbjct: 1350 AVSLLKTFQNTVELIIVRE 1368
Score = 62.4 bits (150), Expect = 3e-09
Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 847 PLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAH 904
P P L ++ + + LGFSI+GG G P+R D GIFV+R+ G A
Sbjct: 1266 PHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPAS 1325
Query: 905 RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE 949
+ LQ GD+++ NG H AVSLL T+ L++ RE
Sbjct: 1326 KL--LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVRE 1368
Score = 61.2 bits (147), Expect = 8e-09
Identities = 31/90 (34%), Positives = 55/90 (61%), Gaps = 3/90 (3%)
Query: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
+E+ ++ LG SI GG G GNP P D+GIF+++V P G A + L+ G +++
Sbjct: 1279 QEIRVRVEKDPELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKII 1335
Query: 1159 EVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
+ N S + + HG+AV LL++ +T+ +++
Sbjct: 1336 QANGYSFINIEHGQAVSLLKTFQNTVELII 1365
Score = 48.1 bits (113), Expect = 7e-05
Identities = 29/77 (37%), Positives = 44/77 (57%), Gaps = 2/77 (2%)
Query: 1003 EEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAV 1061
+EIR+ P LG SI GG +PF + G+F+++V P G A++ L+ GD+I+
Sbjct: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQA 1337
Query: 1062 NGQDVRDATHQEAVSAL 1078
NG + H +AVS L
Sbjct: 1338 NGYSFINIEHGQAVSLL 1354
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 387 bits (994), Expect = e-107
Identities = 219/486 (45%), Positives = 302/486 (62%), Gaps = 14/486 (2%)
Query: 9 RCNRHVESV----DKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKL 64
RC R E + D HCSLQ VP+E++ + R+LEEL LDANQ+ ELPK F LRKL
Sbjct: 15 RCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKL 74
Query: 65 GLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGF 124
+ DN++ LP +A+ + L ELD+S+N + E PE+IK CK L I + S NP+S+LPDGF
Sbjct: 75 SIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGF 134
Query: 125 TQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN 184
TQL +L L LND L+ LP + G L L LELREN LK+LP S+ L +LE+LDLG N
Sbjct: 135 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194
Query: 185 DLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVL 244
+ LP+ L + NLRELW+D N L LP +G L+ LV LD+S+NR+E + ++ G
Sbjct: 195 EFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
Query: 245 LTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMAL 304
L DLLLS N+L++LPD IG LK+L+ LKVD N+L + IG+ L E + N L +L
Sbjct: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314
Query: 305 PRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLD 364
P ++G L L L VD N L LP EIG C ++V+SLR N+L LP E+ +L VL+
Sbjct: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374
Query: 365 VAGNRLQSLPFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLS 423
++ NRL++LPF+ T L L ALWL++NQ++ ++ QTE T ++VLT Y+ PQQP
Sbjct: 375 LSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGD 434
Query: 424 LEDAGQQGSLSET-WSDAPPSRVSV-IQFLEAPIGDEDAEEA------AAEKRGLQRRAT 475
+ S + T W + R++V +F + DE+A + A +RG QR T
Sbjct: 435 EDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERG-QRGIT 493
Query: 476 PHPSEL 481
P+ L
Sbjct: 494 LQPARL 499
Score = 60.1 bits (144), Expect = 2e-08
Identities = 35/86 (40%), Positives = 54/86 (62%), Gaps = 5/86 (5%)
Query: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162
I+K PG LG SI GG G GNP P+D+GIF+++V P G A L+ G ++L+ N
Sbjct: 1451 IEKNPG--LGFSISGGISGQ-GNPFKPSDKGIFVTRVQPDGPA--SNLLQPGDKILQANG 1505
Query: 1163 QSLLGLTHGEAVQLLRSVGDTLTVLV 1188
S + + H +AV LL+S +T+ +++
Sbjct: 1506 HSFVHMEHEKAVLLLKSFQNTVDLVI 1531
Score = 59.7 bits (143), Expect = 2e-08
Identities = 33/81 (40%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 871 GLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARH 928
GLGFSI+GG P++ D GIFV+R+ G A + LQ GD++L NG H
Sbjct: 1456 GLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPA--SNLLQPGDKILQANGHSFVHMEH 1513
Query: 929 DHAVSLLTAASPTIALLLERE 949
+ AV LL + T+ L+++RE
Sbjct: 1514 EKAVLLLKSFQNTVDLVIQRE 1534
Score = 59.3 bits (142), Expect = 3e-08
Identities = 33/88 (37%), Positives = 51/88 (57%), Gaps = 3/88 (3%)
Query: 732 LRQTGGLGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQ 789
+ + GLG SI+GG P+K D+GIF++RV +GPA+ ++ GDK+L+ NG +
Sbjct: 1451 IEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNL-LQPGDKILQANGHSFV 1509
Query: 790 GAEHHEAVEALRGAGTAVQMRVWRERMV 817
EH +AV L+ V + + RE V
Sbjct: 1510 HMEHEKAVLLLKSFQNTVDLVIQRELTV 1537
Score = 47.0 bits (110), Expect = 2e-04
Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 2/88 (2%)
Query: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQ 1064
+R+ + G LG SI GG +PF + G+F+++V P G A+ L+ GD+IL NG
Sbjct: 1449 VRIEKNPG-LGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNL-LQPGDKILQANGH 1506
Query: 1065 DVRDATHQEAVSALLRPCLELSLLVRRD 1092
H++AV L + L+++R+
Sbjct: 1507 SFVHMEHEKAVLLLKSFQNTVDLVIQRE 1534
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 193 bits (490), Expect = 1e-48
Identities = 131/390 (33%), Positives = 200/390 (51%), Gaps = 28/390 (7%)
Query: 12 RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEI 71
+ + +D RH L+ +P +YR SL L L N++ + K L L L + +N+I
Sbjct: 169 KKLRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227
Query: 72 QRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLA 131
++LP E+ L+ LDV+ N + +P+ I C + D N L LPD L SL+
Sbjct: 228 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287
Query: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL-SFLVKLEQLDLGGNDLEVLP 190
L L L A+P + + L L L N + +LP SL S LVKL L L N ++ P
Sbjct: 288 RLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347
Query: 191 -----------------DTLGALPN--------LRELWLDRNQLSALPPELGNLRRLVCL 225
+ + +P L +L + NQL++LP + G +V L
Sbjct: 348 VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVEL 407
Query: 226 DVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAI 285
+++ N+L ++P ++ GLV L L+LS NLL++LP G+G L++L L +++N+L + I
Sbjct: 408 NLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI 467
Query: 286 GDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDN 345
++L +L+LT N L LPR +G LT LT+L + N L LP EIG L L L DN
Sbjct: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
Query: 346 -RLAVLPPELAHTTELHVLDVAGNRLQSLP 374
L LP ELA ++L ++ + L LP
Sbjct: 528 PNLHSLPFELALCSKLSIMSIENCPLSHLP 557
Score = 183 bits (464), Expect = 1e-45
Identities = 124/379 (32%), Positives = 197/379 (51%), Gaps = 5/379 (1%)
Query: 23 SLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82
S+ +P I ++ L EL L +N+L+ LP L+NL L LS+N + LP + N
Sbjct: 111 SIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLK 169
Query: 83 QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142
+L LD+ N + EIP + +L N ++ + L L+ L++ + ++
Sbjct: 170 KLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
Query: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
LP ++G L NL+TL++ N L+ LP + ++ LDL N+L LPDT+G L +L L
Sbjct: 230 LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRL 289
Query: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGGLVLLTDLLLSQNLLRRLP-D 260
L N+LSA+P L L L++ N + LP L LV L L L++N + P
Sbjct: 290 GLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349
Query: 261 GIGQLKQLSILKVDQNRLCEVTEAI-GDCENLSELILTENLLMALPRSLGKLTKLTNLNV 319
G Q + L ++ NR+ ++ I + LS+L + +N L +LP G T + LN+
Sbjct: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
Query: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTH 379
N L +P ++ G V+L VL L +N L LP L + +L LD+ N+L+SLP + +
Sbjct: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469
Query: 380 L-NLKALWLAENQAQPMLR 397
L +L+ L L NQ + R
Sbjct: 470 LKDLQKLVLTNNQLTTLPR 488
Score = 157 bits (397), Expect = 8e-38
Identities = 101/282 (35%), Positives = 153/282 (54%), Gaps = 9/282 (3%)
Query: 111 DFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
D S + LP +L L L L LQ+LP +VG L NL+TL L EN L SLP SL
Sbjct: 106 DLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSL 165
Query: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
L KL LDL N L +P + L +L L+L N+++ + ++ NL +L L + EN
Sbjct: 166 DNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIREN 225
Query: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCEN 290
++++LPAE+G L L L ++ N L LP IG Q++ L + N L ++ + IG+ +
Sbjct: 226 KIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSS 285
Query: 291 LSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPE-IGGCVALSVLSLRDNRLAV 349
LS L L N L A+PRSL K + L LN++ N++ LP + V L+ L+L N +
Sbjct: 286 LSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQL 345
Query: 350 LP-PELAHTTELHVLDVAGNRLQSLPF-------ALTHLNLK 383
P + + ++ L++ NR+ +PF L+ LN+K
Sbjct: 346 YPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMK 387
Score = 141 bits (356), Expect = 5e-33
Identities = 88/241 (36%), Positives = 137/241 (56%), Gaps = 2/241 (0%)
Query: 152 NLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSA 211
N + L+L + + LP+S+ L +L +L L N L+ LP +G L NL L L N L++
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Query: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSIL 271
LP L NL++L LD+ N+L E+P+ + L LT L L N + + I L +LS+L
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
Query: 272 KVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
+ +N++ ++ IG+ NL L + N L LP+ +G T++TNL++ N L LP I
Sbjct: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
Query: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFAL--THLNLKALWLAE 389
G +LS L LR NRL+ +P LA + L L++ N + +LP +L + + L +L LA
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
Query: 390 N 390
N
Sbjct: 341 N 341
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 164 bits (415), Expect = 6e-40
Identities = 136/408 (33%), Positives = 196/408 (48%), Gaps = 60/408 (14%)
Query: 720 ARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGD 778
A E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D
Sbjct: 218 ADYEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVND 274
Query: 779 KLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
+L VN V ++ H +AVEAL+ AG+ V++ V R + V E + I
Sbjct: 275 CILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS-EKIMEIK------------ 321
Query: 839 RRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIA 898
L + +GLGFSIAGG G+ + GD I+V++I
Sbjct: 322 --------------------------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKII 354
Query: 899 EGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG-----GP 953
EGGAAH+ G LQ+GD++L++N V + E H+ AV+ L S + L + + G
Sbjct: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGY 414
Query: 954 LPPSPLPHSSPPT-AAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGG 1012
PP SS P V+ +S TP P S + E ++ L R
Sbjct: 415 APPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST 474
Query: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
LG +IVGG D G+FIS +L G A SG LR GDRI++VN D+R A+H
Sbjct: 475 GLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
Query: 1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGA 1119
++A +AL ++++ + P E I + + SI G+
Sbjct: 526 EQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGS 573
Score = 126 bits (316), Expect = 2e-28
Identities = 94/277 (33%), Positives = 138/277 (49%), Gaps = 15/277 (5%)
Query: 911 VGDRVLSINGVDVTEARHDHAV---SLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTA 967
+G ++ ++ +++E + H S ++ PT A+L +P P+P + T
Sbjct: 130 IGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAEN--TV 187
Query: 968 AVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSH 1027
+ T P + SL + Y EEI L R LG SI GG+D+
Sbjct: 188 ILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDN--- 244
Query: 1028 PFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELS 1086
P + +FI+K++ G AA+ G LRV D IL VN DVRD TH +AV AL +
Sbjct: 245 PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVR 304
Query: 1087 LLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAA 1145
L V RR P + E+ + K P + LG SI GG GN P D I+++K+ GAA
Sbjct: 305 LYVKRRKPVSEKIMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDNSIYVTKIIEGGAA 359
Query: 1146 GRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
+DG+L++G +LL VN L +TH EAV L++ D
Sbjct: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSD 396
Score = 112 bits (280), Expect = 3e-24
Identities = 113/434 (26%), Positives = 177/434 (40%), Gaps = 102/434 (23%)
Query: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
L R GLGFSIAGG + P+ D+ IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 227 LERGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVR 285
Query: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
+ H AV L A + L ++R P+
Sbjct: 286 DVTHSKAVEALKEAGSIVRLYVKRR-------KPVSEK---------------------- 316
Query: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
+ EI+L + LG SI GG + P + ++++K++
Sbjct: 317 -----------------IMEIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 356
Query: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL--------LRPCLELSLLVRRDPAP 1095
G A + G L++GD++LAVN + + TH+EAV+AL L+ S+ + AP
Sbjct: 357 GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416
Query: 1096 PGLRELCIQK-----APGERLGISIRGGAR---------GHAGNPRDPTD---------- 1131
P + Q +P LG + AR G R+P
Sbjct: 417 PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGL 476
Query: 1132 ----------EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
EGIFIS + G A G LR G R++ VN L +H +A L++ G
Sbjct: 477 GFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536
Query: 1182 DTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEG 1235
+T++ FEA ++ ++ + ++G G + + S R L
Sbjct: 537 QAVTIVAQYRPEEYSRFEAKIH---DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYD 593
Query: 1236 PGKEKELPGQTLHW 1249
K+ LP Q L++
Sbjct: 594 KTKDSGLPSQGLNF 607
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 164 bits (415), Expect = 6e-40
Identities = 136/408 (33%), Positives = 196/408 (48%), Gaps = 60/408 (14%)
Query: 720 ARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGD 778
A E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D
Sbjct: 218 ADYEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVND 274
Query: 779 KLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
+L VN V ++ H +AVEAL+ AG+ V++ V R + V E + I
Sbjct: 275 CILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS-EKIMEIK------------ 321
Query: 839 RRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIA 898
L + +GLGFSIAGG G+ + GD I+V++I
Sbjct: 322 --------------------------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKII 354
Query: 899 EGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG-----GP 953
EGGAAH+ G LQ+GD++L++N V + E H+ AV+ L S + L + + G
Sbjct: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGY 414
Query: 954 LPPSPLPHSSPPT-AAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGG 1012
PP SS P V+ +S TP P S + E ++ L R
Sbjct: 415 APPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGST 474
Query: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
LG +IVGG D G+FIS +L G A SG LR GDRI++VN D+R A+H
Sbjct: 475 GLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
Query: 1072 QEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGA 1119
++A +AL ++++ + P E I + + SI G+
Sbjct: 526 EQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGS 573
Score = 126 bits (316), Expect = 2e-28
Identities = 94/277 (33%), Positives = 138/277 (49%), Gaps = 15/277 (5%)
Query: 911 VGDRVLSINGVDVTEARHDHAV---SLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTA 967
+G ++ ++ +++E + H S ++ PT A+L +P P+P + T
Sbjct: 130 IGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAEN--TV 187
Query: 968 AVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSH 1027
+ T P + SL + Y EEI L R LG SI GG+D+
Sbjct: 188 ILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDN--- 244
Query: 1028 PFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELS 1086
P + +FI+K++ G AA+ G LRV D IL VN DVRD TH +AV AL +
Sbjct: 245 PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVR 304
Query: 1087 LLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAA 1145
L V RR P + E+ + K P + LG SI GG GN P D I+++K+ GAA
Sbjct: 305 LYVKRRKPVSEKIMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDNSIYVTKIIEGGAA 359
Query: 1146 GRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
+DG+L++G +LL VN L +TH EAV L++ D
Sbjct: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSD 396
Score = 112 bits (280), Expect = 3e-24
Identities = 113/434 (26%), Positives = 177/434 (40%), Gaps = 102/434 (23%)
Query: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
L R GLGFSIAGG + P+ D+ IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 227 LERGNSGLGFSIAGGTDN-PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVR 285
Query: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
+ H AV L A + L ++R P+
Sbjct: 286 DVTHSKAVEALKEAGSIVRLYVKRR-------KPVSEK---------------------- 316
Query: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
+ EI+L + LG SI GG + P + ++++K++
Sbjct: 317 -----------------IMEIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 356
Query: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL--------LRPCLELSLLVRRDPAP 1095
G A + G L++GD++LAVN + + TH+EAV+AL L+ S+ + AP
Sbjct: 357 GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416
Query: 1096 PGLRELCIQK-----APGERLGISIRGGAR---------GHAGNPRDPTD---------- 1131
P + Q +P LG + AR G R+P
Sbjct: 417 PDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGL 476
Query: 1132 ----------EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
EGIFIS + G A G LR G R++ VN L +H +A L++ G
Sbjct: 477 GFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536
Query: 1182 DTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEG 1235
+T++ FEA ++ ++ + ++G G + + S R L
Sbjct: 537 QAVTIVAQYRPEEYSRFEAKIH---DLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYD 593
Query: 1236 PGKEKELPGQTLHW 1249
K+ LP Q L++
Sbjct: 594 KTKDSGLPSQGLNF 607
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens]
Length = 767
Score = 161 bits (407), Expect = 5e-39
Identities = 135/420 (32%), Positives = 199/420 (47%), Gaps = 66/420 (15%)
Query: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
+E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D +
Sbjct: 104 MEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160
Query: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
L VN V ++ H AVEAL+ AG+ V++ V R +
Sbjct: 161 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP------------------------ 196
Query: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
P E ++ L + +GLGFSIAGG G+ + GD I+V++I EG
Sbjct: 197 ---------PAEKVMEIK------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKIIEG 240
Query: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVS---------LLTAASPTIALLLEREAG 951
GAAH+ G LQ+GD++L++N V + + H+ AV+ L A P+ A L + A
Sbjct: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
Query: 952 GPLPPS---PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008
+ S L + ++ + T T TP P S L + P I +
Sbjct: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
Query: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
R LG +IVGG D G+FIS +L G A SG LR GD+IL+VNG D+R
Sbjct: 361 RGSTGLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
Query: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
+A+H++A AL ++++ + P E I + + S+ G NP+
Sbjct: 412 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 471
Score = 121 bits (304), Expect = 5e-27
Identities = 90/236 (38%), Positives = 120/236 (50%), Gaps = 18/236 (7%)
Query: 958 PLPHSS---PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPL 1014
PL HS P A + T T PG L EG EEI L R L
Sbjct: 64 PLEHSPAHLPNQANSPPVIVNTDTLEAPGY-----ELQVNGTEGEMEYEEITLERGNSGL 118
Query: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
G SI GG+D+ P +P +FI+K++P G AA+ G LRV D IL VN DVR+ TH
Sbjct: 119 GFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175
Query: 1074 AVSALLRPCLELSLLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDE 1132
AV AL + L V RR P + E+ + K P + LG SI GG GN P D
Sbjct: 176 AVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDN 230
Query: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
I+++K+ GAA +DGRL++G ++L VN L + H +AV L++ D + + V
Sbjct: 231 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
Score = 107 bits (266), Expect = 1e-22
Identities = 103/372 (27%), Positives = 146/372 (39%), Gaps = 99/372 (26%)
Query: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
L R GLGFSIAGG + P+ D IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 111 LERGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 169
Query: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
E H AV L A + L + R PP V
Sbjct: 170 EVTHSAAVEALKEAGSIVRLYVMRR-------------KPPAEKVM-------------- 202
Query: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
EI+L + LG SI GG + P + ++++K++
Sbjct: 203 -------------------EIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 240
Query: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP--------AP 1095
G A + G L++GD+ILAVN + D H++AV+AL + L V + AP
Sbjct: 241 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 300
Query: 1096 PGLRELCIQKAPGERLGISIRG--------------------GARGHAGNPRDPT----- 1130
P + Q E S G G PR+P
Sbjct: 301 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 360
Query: 1131 ---------------DEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQ 1175
EGIFIS + G A G LR G ++L VN L +H +A
Sbjct: 361 RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
Query: 1176 LLRSVGDTLTVL 1187
L++ G T+T++
Sbjct: 421 ALKNAGQTVTII 432
Score = 58.5 bits (140), Expect = 5e-08
Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
LG SI GG NP D IFI+K+ P GAA +DGRLRV +L VN+ + +TH
Sbjct: 118 LGFSIAGGT----DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 173
Query: 1171 GEAVQLLRSVGDTLTVLVC---DGFEASTDAALEVSPGVIANPFAAGIGHRN 1219
AV+ L+ G + + V E + L P + A G+G+++
Sbjct: 174 SAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQH 225
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 161 bits (407), Expect = 5e-39
Identities = 135/420 (32%), Positives = 199/420 (47%), Gaps = 66/420 (15%)
Query: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
+E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D +
Sbjct: 58 MEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 114
Query: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
L VN V ++ H AVEAL+ AG+ V++ V R +
Sbjct: 115 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP------------------------ 150
Query: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
P E ++ L + +GLGFSIAGG G+ + GD I+V++I EG
Sbjct: 151 ---------PAEKVMEIK------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKIIEG 194
Query: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVS---------LLTAASPTIALLLEREAG 951
GAAH+ G LQ+GD++L++N V + + H+ AV+ L A P+ A L + A
Sbjct: 195 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254
Query: 952 GPLPPS---PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008
+ S L + ++ + T T TP P S L + P I +
Sbjct: 255 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314
Query: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
R LG +IVGG D G+FIS +L G A SG LR GD+IL+VNG D+R
Sbjct: 315 RGSTGLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
Query: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
+A+H++A AL ++++ + P E I + + S+ G NP+
Sbjct: 366 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 425
Score = 120 bits (300), Expect = 1e-26
Identities = 89/236 (37%), Positives = 120/236 (50%), Gaps = 21/236 (8%)
Query: 958 PLPHSS---PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPL 1014
PL HS P A + T T PG + EG EEI L R L
Sbjct: 21 PLEHSPAHLPNQANSPPVIVNTDTLEAPGYVN--------GTEGEMEYEEITLERGNSGL 72
Query: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
G SI GG+D+ P +P +FI+K++P G AA+ G LRV D IL VN DVR+ TH
Sbjct: 73 GFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129
Query: 1074 AVSALLRPCLELSLLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDE 1132
AV AL + L V RR P + E+ + K P + LG SI GG GN P D
Sbjct: 130 AVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDN 184
Query: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
I+++K+ GAA +DGRL++G ++L VN L + H +AV L++ D + + V
Sbjct: 185 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
Score = 107 bits (266), Expect = 1e-22
Identities = 103/372 (27%), Positives = 146/372 (39%), Gaps = 99/372 (26%)
Query: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
L R GLGFSIAGG + P+ D IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 65 LERGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 123
Query: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
E H AV L A + L + R PP V
Sbjct: 124 EVTHSAAVEALKEAGSIVRLYVMRR-------------KPPAEKVM-------------- 156
Query: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
EI+L + LG SI GG + P + ++++K++
Sbjct: 157 -------------------EIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 194
Query: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP--------AP 1095
G A + G L++GD+ILAVN + D H++AV+AL + L V + AP
Sbjct: 195 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254
Query: 1096 PGLRELCIQKAPGERLGISIRG--------------------GARGHAGNPRDPT----- 1130
P + Q E S G G PR+P
Sbjct: 255 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314
Query: 1131 ---------------DEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQ 1175
EGIFIS + G A G LR G ++L VN L +H +A
Sbjct: 315 RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
Query: 1176 LLRSVGDTLTVL 1187
L++ G T+T++
Sbjct: 375 ALKNAGQTVTII 386
Score = 58.5 bits (140), Expect = 5e-08
Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
LG SI GG NP D IFI+K+ P GAA +DGRLRV +L VN+ + +TH
Sbjct: 72 LGFSIAGGT----DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127
Query: 1171 GEAVQLLRSVGDTLTVLVC---DGFEASTDAALEVSPGVIANPFAAGIGHRN 1219
AV+ L+ G + + V E + L P + A G+G+++
Sbjct: 128 SAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQH 179
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 156 bits (394), Expect = 2e-37
Identities = 108/380 (28%), Positives = 196/380 (51%), Gaps = 5/380 (1%)
Query: 16 SVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLP 75
S+D + ++P+EI R ++LE LL+D N+L L F+LL +++L L+DN+++ +
Sbjct: 307 SLDLTGNLISSLPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVIS 365
Query: 76 PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLAL 135
++ NF +L L + +N + IPE I C LE S N L+ LP +L +L L +
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
Query: 136 NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195
N ++ + + +L N+ +LE N++ +P + K+ +++L N + P L A
Sbjct: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCA 485
Query: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255
L +L L ++ N +S +P ++ ++L+ L++SEN+L L+ L L L +N +
Sbjct: 486 LDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQI 545
Query: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315
+++P I + L +L + N+ + ENL L L+EN L + + L +
Sbjct: 546 KKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQ 605
Query: 316 NLNVDRNHLEALPPE---IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQS 372
LN N P E + L++ ++ +L LP EL++ T+L LD++ N ++
Sbjct: 606 KLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE 665
Query: 373 LPFALTHL-NLKALWLAENQ 391
+P + L NL +L NQ
Sbjct: 666 IPRNIGELRNLVSLHAYNNQ 685
Score = 155 bits (393), Expect = 2e-37
Identities = 108/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
L+ +PE+I LE L L N+L ELPK +L NLRKL ++ N + ++ +++
Sbjct: 384 LKNIPEKI-SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNN 442
Query: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143
+ L+ S N I ++P IK C+ + + S N + P G L SL +L++N + +
Sbjct: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEI 502
Query: 144 PGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELW 203
P D+ L+ LEL EN L L+ L+ LDLG N ++ +P ++ + +L L
Sbjct: 503 PVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLI 562
Query: 204 LDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIG 263
L N+ P EL L L LD+SEN+L+++ +++ L + L S N P +
Sbjct: 563 LCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELC 622
Query: 264 QLKQLSILKVDQNRLCEVTEAIGDCEN---LSELILTENLLMALPRSLGKLTKLTNLNVD 320
QL+ L L + Q + ++T G+ N L EL ++ N + +PR++G+L L +L+
Sbjct: 623 QLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY 682
Query: 321 RNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
N + LPP + L L+L N L LP + + L ++ N L P
Sbjct: 683 NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
Score = 154 bits (388), Expect = 9e-37
Identities = 112/404 (27%), Positives = 194/404 (48%), Gaps = 25/404 (6%)
Query: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
+E + + L ++P EI + +L L + N + +PK +L N+R+L +N I+
Sbjct: 190 LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248
Query: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
P ++ L L + +N + IP+++ K L + + N L+ P L L L
Sbjct: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308
Query: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
L + +LP ++ L NL TL + N L L + L+K+++L L N LEV+ +
Sbjct: 309 DLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI 368
Query: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
LR L LD+N L +P ++ L CL +S+N+L ELP + L L L +++N
Sbjct: 369 ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
+ ++ D I L + L+ N + +V I +C+ + ++ L+ N +M P L L
Sbjct: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV-----------------------L 350
L L+V+ N++ +P +I L L L +N+L + +
Sbjct: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
Query: 351 PPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393
P +++ LHVL + N+ ++ P L L NL+ L L+ENQ Q
Sbjct: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQ 592
Score = 152 bits (385), Expect = 2e-36
Identities = 108/356 (30%), Positives = 172/356 (48%), Gaps = 1/356 (0%)
Query: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
+LE L L N+LR +P L LR L L N++ P + +L+ LD++ N I
Sbjct: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
Query: 97 IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156
+P+ I+ K LE N L+ L QL + L L D L+ + + N L L
Sbjct: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377
Query: 157 ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216
L +NLLK++P +S LE L L N L LP + L NLR+L ++RN + + +
Sbjct: 378 ILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCI 437
Query: 217 GNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQN 276
+L + L+ S N + ++P E+ + + LS N + P G+ L L L V+ N
Sbjct: 438 SHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
Query: 277 RLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336
+ E+ I + L L L+EN L+ L L L++ +N ++ +P I ++
Sbjct: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
Query: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391
L VL L N+ P EL L VLD++ N+LQ + + +L ++ L + NQ
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
Score = 147 bits (370), Expect = 1e-34
Identities = 109/370 (29%), Positives = 177/370 (47%), Gaps = 3/370 (0%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELP-KPFFRLLNLRKLGLSDNEIQRLPPEVANFM 82
LQ P++I + + ++ L LD NQ++ LL L L L +N + LP E+
Sbjct: 153 LQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLH 211
Query: 83 QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQA 142
L L+VS N I IP+ I + F N + P L +L L+L L+
Sbjct: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
Query: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
+P + +L L L L N L + P +L FL KL LDL GN + LP + L NL L
Sbjct: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETL 331
Query: 203 WLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGI 262
+D N+L+ L E+ L ++ L +++N+LE + ++ L L+L +NLL+ +P+ I
Sbjct: 332 LMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKI 391
Query: 263 GQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRN 322
L L + N+L E+ + I NL +L + N ++ + + L + +L N
Sbjct: 392 SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGN 451
Query: 323 HLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALT-HLN 381
+ +P EI C + + L N++ P L L+ L V GN + +P ++
Sbjct: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQ 511
Query: 382 LKALWLAENQ 391
L L L+EN+
Sbjct: 512 LLHLELSENK 521
Score = 103 bits (258), Expect = 1e-21
Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 4/248 (1%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
+ +P +I +S+ L L L N+L + F L+NL+ L L N+I+++P ++N +
Sbjct: 499 ISEIPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
Query: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL 143
L L + N P + + L++ D S N L ++ L+ + L +
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
Query: 144 PGDVGNLANLVTL---ELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200
P ++ L +L L +++ L LP LS + +L++LD+ N + +P +G L NL
Sbjct: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLV 677
Query: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
L NQ+S LPP L +L L L++S N L LP+ + + L ++ N L R P
Sbjct: 678 SLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPV 737
Query: 261 GIGQLKQL 268
I + KQL
Sbjct: 738 EICKGKQL 745
Score = 98.6 bits (244), Expect = 4e-20
Identities = 61/201 (30%), Positives = 106/201 (52%), Gaps = 3/201 (1%)
Query: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
SL L+L N+ P+ L NL+ L LS+N++Q++ ++ N + +L+ S N
Sbjct: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616
Query: 97 IPESIKFCKALE---IADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANL 153
P + ++LE I+ G L+RLP + + L L +++ +++ +P ++G L NL
Sbjct: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
Query: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213
V+L N + LP SL L L+QL+L GN+L LP + + +L+E+ D N L P
Sbjct: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
Query: 214 PELGNLRRLVCLDVSENRLEE 234
E+ ++L + R +E
Sbjct: 737 VEICKGKQLYTIARYLQRADE 757
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 155 bits (392), Expect = 3e-37
Identities = 122/377 (32%), Positives = 184/377 (48%), Gaps = 25/377 (6%)
Query: 17 VDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPP 76
+D + SL A+P EI+ ++ LEE+ L+ NQ+ E+P+ RL N+R L L N ++ L P
Sbjct: 30 IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
Query: 77 EVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALN 136
+ L LD+S N I F +L + F L +L L L
Sbjct: 89 ALGLLSSLESLDLSYNPI--------FSSSLVVVSF--------------LHALRELRLY 126
Query: 137 DVSLQALPGDV-GNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA 195
L+ +P + NL +L L L N LK LP + KL ++ L N EV P L
Sbjct: 127 QTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCV 186
Query: 196 LPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL 255
L L + LD N++ A+P E+G+L L ++ N L LPA L L+ L LS NLL
Sbjct: 187 LYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLL 246
Query: 256 RRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLT 315
+P +L++++ + + NRL +V I +L L L L L S L L
Sbjct: 247 HSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLR 306
Query: 316 NLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPF 375
L++ +NHL P +I L VL L DN++ LP EL ++L +L + GN S P
Sbjct: 307 FLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPE 366
Query: 376 ALTHL-NLKALWLAENQ 391
+ L +L+ L++ ++Q
Sbjct: 367 EVLSLASLEKLYIGQDQ 383
Score = 155 bits (392), Expect = 3e-37
Identities = 123/407 (30%), Positives = 188/407 (46%), Gaps = 29/407 (7%)
Query: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN-LRKLGLSDNEIQ 72
+ES+D + + + + + +L EL L L+E+P F+ L+ L LGL+ N ++
Sbjct: 96 LESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLK 155
Query: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
LP E+ N +L E+ + RN P+ + LEI D N + +P+ L L
Sbjct: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQK 215
Query: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLP-- 190
+ +L LP + + L L+L NLL S+P S + L K+ ++ L GN LE +P
Sbjct: 216 FYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRL 275
Query: 191 ---------------------DTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSE 229
+ L NLR L L +N L P ++ L+ L L + +
Sbjct: 276 ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDD 335
Query: 230 NRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQN---RLCEVTEAIG 286
N++ +LP+ELG L L L L+ N P+ + L L L + Q+ +L V E I
Sbjct: 336 NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIR 395
Query: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNR 346
++L EL + N L LP SLG + L L+ N L+ LP I AL L L DN
Sbjct: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
Query: 347 LAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALW--LAENQ 391
L LP L L VL + N ++ P + +A+W L EN+
Sbjct: 456 LTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENR 502
Score = 153 bits (386), Expect = 1e-36
Identities = 111/358 (31%), Positives = 174/358 (48%), Gaps = 6/358 (1%)
Query: 2 LKCIP--LWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLL 59
LK IP +++ H+E + L+ +P+EI ++ L E+ L NQ P+ L
Sbjct: 130 LKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLY 188
Query: 60 NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 119
L + L +N+I +P E+ + L + ++ N++P +P S+ C L + D S N L
Sbjct: 189 TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHS 248
Query: 120 LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
+P F +LR + + L+ L+ +P + +L L L L L S LV L L
Sbjct: 249 IPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFL 308
Query: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239
DL N L P + AL NL L LD N++ LP ELG+L +L L ++ N P E+
Sbjct: 309 DLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEV 368
Query: 240 GGLVLLTDLLLSQN---LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELIL 296
L L L + Q+ L +P+ I +L+ L L ++ N L + ++G NL L
Sbjct: 369 LSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDC 428
Query: 297 TENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL 354
NLL LP ++ + L L ++ N L LP + V L VL+L DN + P E+
Sbjct: 429 RHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
Score = 66.2 bits (160), Expect = 2e-10
Identities = 53/219 (24%), Positives = 85/219 (38%), Gaps = 49/219 (22%)
Query: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
R +D S L +P E+ L ++ L N + +P I +LK + +L +D+N L
Sbjct: 26 RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRS 85
Query: 281 VTEAIG------------------------------------------------DCENLS 292
+ A+G + +L
Sbjct: 86 LCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLE 145
Query: 293 ELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPP 352
L LT N L LP+ + TKL + + RN E P E+ L ++ L +N++ +P
Sbjct: 146 LLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPE 205
Query: 353 ELAHTTELHVLDVAGNRLQSLPFALTHLN-LKALWLAEN 390
E+ H T L +A N L LP +L + L L L+ N
Sbjct: 206 EIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHN 244
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 152 bits (384), Expect = 3e-36
Identities = 133/416 (31%), Positives = 194/416 (46%), Gaps = 91/416 (21%)
Query: 717 IEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VR 775
+ IE E +T+ R GLG SIAGG + P+ GDD GIFI+++ G AA G +R
Sbjct: 36 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPGGAAAEDGRLR 94
Query: 776 VGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYS 835
V D +L VN V + H +AVEAL+ AG+ V++ V R R + E V I
Sbjct: 95 VNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-ETVVEIK--------- 144
Query: 836 PRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVS 895
L + +GLGFSIAGG G+ + GD I+V+
Sbjct: 145 -----------------------------LFKGPKGLGFSIAGGVGNQ-HIPGDNSIYVT 174
Query: 896 RIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREA----G 951
+I +GGAA + G LQVGDR+L +N + E H+ AV++L S + L + +
Sbjct: 175 KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMT 234
Query: 952 GPLPPSPLPHS-SPP------TAAVATTSITTATPGV-PGLPSLAPSLL----------- 992
P P + HS SPP + T T+ P + PG S P +
Sbjct: 235 DPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQ 294
Query: 993 --------------AAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038
A +LEG ++ L + LG +IVGG D G+F+
Sbjct: 295 HSTATRQPSMTLQRAVSLEG--EPRKVVLHKGSTGLGFNIVGGEDGE---------GIFV 343
Query: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
S +L G A SG L+ GD+IL+VNG D+R A+H++A +AL ++++ + P
Sbjct: 344 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 399
Score = 124 bits (311), Expect = 7e-28
Identities = 98/258 (37%), Positives = 134/258 (51%), Gaps = 26/258 (10%)
Query: 1000 YPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRI 1058
Y EEI L R LG SI GG+D+ P +PG+FI+K++P G AA G LRV D I
Sbjct: 43 YEFEEITLERGNSGLGFSIAGGTDN---PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99
Query: 1059 LAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD-PAPPGLRELCIQKAPGERLGISIRG 1117
L VN DV + +H +AV AL + L VRR P + E+ + K P + LG SI G
Sbjct: 100 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGP-KGLGFSIAG 158
Query: 1118 GARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
G GN P D I+++K+ GAA +DGRL+VG RLL VN SL +TH EAV +L
Sbjct: 159 GV----GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAIL 214
Query: 1178 RS--------VGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDR 1229
++ VG T+ + D + D SP + + + G+ +LE +S
Sbjct: 215 KNTSEVVYLKVGKPTTIYMTDPY-GPPDITHSYSPPMENHLLS---GNNGTLEYKTS--- 267
Query: 1230 ELSPEGPGKEKELPGQTL 1247
L P PG+ +P L
Sbjct: 268 -LPPISPGRYSPIPKHML 284
Score = 62.4 bits (150), Expect = 3e-09
Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 8/98 (8%)
Query: 711 QANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAA 770
Q + L +E E + + + + GLG +I GG+ D EGIF+S + GPA
Sbjct: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE-------DGEGIFVSFILAGGPAD 353
Query: 771 RAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAV 807
+G ++ GD++L VNG+ L+GA H +A AL+GAG V
Sbjct: 354 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 391
Score = 48.1 bits (113), Expect = 7e-05
Identities = 47/184 (25%), Positives = 79/184 (42%), Gaps = 23/184 (12%)
Query: 1070 THQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDP 1129
+H + +A +P + L V + P R++ + K LG +I GG G
Sbjct: 291 SHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-STGLGFNIVGGEDG-------- 338
Query: 1130 TDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV- 1188
EGIF+S + G A G L+ G ++L VN L G +H +A L+ G T+T++
Sbjct: 339 --EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
Query: 1189 -----CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELP 1243
FEA ++ ++ + ++G G + + S R + K+ LP
Sbjct: 397 YQPEDYARFEAKIH---DLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLP 453
Query: 1244 GQTL 1247
Q L
Sbjct: 454 SQGL 457
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 150 bits (379), Expect = 1e-35
Identities = 147/497 (29%), Positives = 215/497 (43%), Gaps = 118/497 (23%)
Query: 726 ELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVN 784
E T+ I + GLG+SI GG + I I V EEG A + G + GD++LEVN
Sbjct: 1627 ETTIEISKGRTGLGLSIVGGSDTLL-----GAIIIHEVYEEGAACKDGRLWAGDQILEVN 1681
Query: 785 GVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGL 844
G+ L+ A H EA+ LR V++ ++R+ E V T
Sbjct: 1682 GIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT------------------ 1723
Query: 845 RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAH 904
L + + PG +GLG SI G + D G+FVS I +GG A
Sbjct: 1724 -LTIELQKKPG--------------KGLGLSIVG-------KRNDTGVFVSDIVKGGIAD 1761
Query: 905 RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964
G L GD++L +NG DV A + +LL + G L P S
Sbjct: 1762 ADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE------------GSLSSFTFPLSGS 1809
Query: 965 PTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDH 1024
T+ + S + LA+ ++G VE + P LG+SI GG
Sbjct: 1810 STSESLES-------------SSKKNALASEIQGLRTVEMKKGPT--DSLGISIAGG--- 1851
Query: 1025 SSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRILAVNGQDVRDATHQEAV-------- 1075
P G + +FI+ + P G+AA++ LRVGDRI+ + G TH +AV
Sbjct: 1852 VGSPLG--DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG 1909
Query: 1076 ------------------------SALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERL 1111
S+L L S + + D PP + + +++ P + L
Sbjct: 1910 SIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGP-DGL 1968
Query: 1112 GISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHG 1171
G SI GG G+P D I++ V GAA DGRL+ G +++ VN QSL G+TH
Sbjct: 1969 GFSIVGG----YGSPHG--DLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2022
Query: 1172 EAVQLLRSVGDTLTVLV 1188
EAV +L+ T+T++V
Sbjct: 2023 EAVAILKRTKGTVTLMV 2039
Score = 137 bits (344), Expect = 1e-31
Identities = 140/504 (27%), Positives = 216/504 (42%), Gaps = 81/504 (16%)
Query: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795
GLG+S+AG K + +FI + G A + G +++ D+LLE+NG L G H
Sbjct: 1359 GLGLSLAGNKDRSRMS-----VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQN 1413
Query: 796 AVEALRGAGTAVQMRVWRERMVEPENAV----TITPLRPEDDYSPRERRGGGLRLPLLPP 851
A ++ A + V++ R + + AV + PL + + +
Sbjct: 1414 ASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAV 1473
Query: 852 ESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQV 911
+ +H+ L + + GLG +I+ + G+ + + E G A G L+V
Sbjct: 1474 DLSSFKNVQHLE-LPKDQGGLGIAISEEDTLS-------GVIIKSLTEHGVAATDGRLKV 1525
Query: 912 GDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE-------------AGG------ 952
GD++L+++ V + +SLL A T+ L + E A G
Sbjct: 1526 GDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSS 1585
Query: 953 -----PLPPSPLPHSSPPTAAVATTSITTATPGV-PGLPSLAPSLLAAALEGPYPVEEIR 1006
P SP P S T+ +T +I + P P +P ++ EI
Sbjct: 1586 QSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTI------------EIS 1633
Query: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 1065
R G LGLSIVGGSD + I +V G A + G L GD+IL VNG D
Sbjct: 1634 KGRTG--LGLSIVGGSD-------TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
Query: 1066 VRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELC------IQKAPGERLGISIRGGA 1119
+R ATH EA++ L + + L + RD AP E+C +QK PG+ LG+SI G
Sbjct: 1685 LRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKR 1744
Query: 1120 RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
D G+F+S + G A DGRL G ++L VN + + T LL+
Sbjct: 1745 N----------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKV 1794
Query: 1180 VGDTLTVLVCDGFEASTDAALEVS 1203
+L+ +ST +LE S
Sbjct: 1795 SEGSLSSFTFPLSGSSTSESLESS 1818
Score = 133 bits (335), Expect = 1e-30
Identities = 141/529 (26%), Positives = 218/529 (41%), Gaps = 134/529 (25%)
Query: 729 LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVA 787
L + + GGLGI+I+ + G+ I ++E G AA G ++VGD++L V+
Sbjct: 1484 LELPKDQGGLGIAISE-------EDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEI 1536
Query: 788 LQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLP 847
+ G + + L+ A V++ + E P++ P ++ L +P
Sbjct: 1537 VVGYPIEKFISLLKTAKMTVKLTIHAEN---PDSQAV--PSAAGAASGEKKNSSQSLMVP 1591
Query: 848 LLPPESPGPLRQRH------------VAC-----------LARSERGLGFSIAGGKGSTP 884
P +R C +++ GLG SI GG +
Sbjct: 1592 QSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLL 1651
Query: 885 YRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944
I + + E GAA + G L GD++L +NG+D+ +A HD A+++L + L
Sbjct: 1652 -----GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
Query: 945 LLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEE 1004
L R+ E PY EE
Sbjct: 1707 TLYRD-----------------------------------------------EAPYKEEE 1719
Query: 1005 I-------RLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGD 1056
+ + G LGLSIVG + + GVF+S ++ G+A G L GD
Sbjct: 1720 VCDTLTIELQKKPGKGLGLSIVGKRN---------DTGVFVSDIVKGGIADADGRLMQGD 1770
Query: 1057 RILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAP--------------------- 1095
+IL VNG+DVR+AT QEAV+ALL+ E SL P
Sbjct: 1771 QILMVNGEDVRNAT-QEAVAALLKVS-EGSLSSFTFPLSGSSTSESLESSSKKNALASEI 1828
Query: 1096 PGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGL 1155
GLR + ++K P + LGISI GG G D IFI+ + PTG A + +LRVG
Sbjct: 1829 QGLRTVEMKKGPTDSLGISIAGGVGSPLG------DVPIFIAMMHPTGVAAQTQKLRVGD 1882
Query: 1156 RLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSP 1204
R++ + S G+TH +AV LL++ ++ + V G + S + P
Sbjct: 1883 RIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEP 1931
Score = 112 bits (281), Expect = 2e-24
Identities = 143/563 (25%), Positives = 216/563 (38%), Gaps = 148/563 (26%)
Query: 738 LGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
LGISI GG+G + E GIFI V E+ PA + G ++ GD+++EV+G+ L+ A H
Sbjct: 1162 LGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221
Query: 794 HEAVEALRGAGTAVQMRVWR--------------ERMVEPENAVTITP----LRPEDDYS 835
+AVEA+R AG V V + N + P L+ D +
Sbjct: 1222 EQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
Query: 836 PRERRGGGLRLPL--LPPESPGP--------------------------------LRQR- 860
P + + PL +PP P +R+R
Sbjct: 1282 PSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERY 1341
Query: 861 -------HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGD 913
H+ L + GLG S+AG K + +F+ I GAA + G LQ+ D
Sbjct: 1342 GTLTGELHMIELEKGHSGLGLSLAGNKDRSRM-----SVFIVGIDPNGAAGKDGRLQIAD 1396
Query: 914 RVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTS 973
+L ING + H +A S++ A + ++ R + P + A S
Sbjct: 1397 ELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGN----AVEPLPS 1452
Query: 974 ITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQE 1033
+ P++ S A L V+ + LP+ G LG++I S
Sbjct: 1453 NSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLS-------- 1504
Query: 1034 PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD 1092
GV I + G+AA G L+VGD+ILAV+ + V ++ +S L + + L + +
Sbjct: 1505 -GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAE 1563
Query: 1093 --------------------------------PAPPGLR--------------------- 1099
P P +R
Sbjct: 1564 NPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPII 1623
Query: 1100 ---ELCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGL 1155
E I+ + G LG+SI GG+ D I I +V GAA +DGRL G
Sbjct: 1624 PGCETTIEISKGRTGLGLSIVGGS--------DTLLGAIIIHEVYEEGAACKDGRLWAGD 1675
Query: 1156 RLLEVNQQSLLGLTHGEAVQLLR 1178
++LEVN L TH EA+ +LR
Sbjct: 1676 QILEVNGIDLRKATHDEAINVLR 1698
Score = 103 bits (256), Expect = 2e-21
Identities = 101/353 (28%), Positives = 158/353 (44%), Gaps = 83/353 (23%)
Query: 871 GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEA-RHD 929
GLGFS+ G + G+ GIFV I EG AHR G L+ D++L+ING + + H
Sbjct: 147 GLGFSVVGLRSEN---RGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 930 HAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAP 989
A+S+L A T+ L++ R G LP P S +A +T S
Sbjct: 204 QAISILQKAKDTVQLVIAR---GSLPQLVSPIVSRSPSAASTIS---------------- 244
Query: 990 SLLAAALEGPYP---VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGL 1046
A P +E I L G LG I+GG + GV + +LP G+
Sbjct: 245 -----AHSNPVHWQHMETIELVNDGSGLGFGIIGG----------KATGVIVKTILPGGV 289
Query: 1047 AARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC-LELSLLVRR------------- 1091
A + G L GD IL + D+ + E V+ +LR C + L++ R
Sbjct: 290 ADQHGRLCSGDHILKIGDTDLAGMS-SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALG 348
Query: 1092 ---DPAPPGLRELCIQKAP--GER--------------LGISIRGGARGHAGNPR-DPTD 1131
+P EL + + GE LGI+I G + G+ + +P+
Sbjct: 349 ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAG----YIGDKKLEPS- 403
Query: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTL 1184
GIF+ ++ + A DGR+++G +++ V+ +L G T+ +AV++LR G T+
Sbjct: 404 -GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTV 455
Score = 91.7 bits (226), Expect = 5e-18
Identities = 126/597 (21%), Positives = 226/597 (37%), Gaps = 148/597 (24%)
Query: 712 ANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR 771
A ++++ E E T+ I + LG++++ K D G+ + + G +R
Sbjct: 992 AECVMLQNVSKESFERTINIAKGNSSLGMTVSANK-------DGLGMIVRSIIHGGAISR 1044
Query: 772 AG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRP 830
G + +GD +L +N + + +A LR R ++ P+ +T P
Sbjct: 1045 DGRIAIGDCILSINEESTISVTNAQARAMLR-----------RHSLIGPDIKITYVPAEH 1093
Query: 831 EDDY--SPRERRGG-----------GLRLPLLPPESPGPLRQ--------------RHVA 863
+++ S ++ G G +P LP G + R V
Sbjct: 1094 LEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVE 1153
Query: 864 CLARSERGLGFSIAGGKG-STPYRAGDA--GIFVSRIAEGGAAHRAGTLQVGDRVLSING 920
+ LG SI GG+G + G+ GIF+ + E A + GTL+ GDR++ ++G
Sbjct: 1154 LWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDG 1213
Query: 921 VDVTEARHDHAV-SLLTAASPTIAL---LLEREAGGPLP--------------PSPLPHS 962
+D+ +A H+ AV ++ A +P + + ++ R PLP +P S
Sbjct: 1214 MDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADS 1273
Query: 963 SPPTAAVATTSITTATPGVP--GLPSLAPSLLA--------------------------- 993
A A + + P +P PS A
Sbjct: 1274 LQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYS 1333
Query: 994 --------AALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRG 1045
L G + E+ +G LGLS+ G D S VFI + P G
Sbjct: 1334 WKNIRERYGTLTGELHMIELEKGHSG--LGLSLAGNKDRS-------RMSVFIVGIDPNG 1384
Query: 1046 LAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELC-- 1102
A + G L++ D +L +NGQ + +HQ A S + ++ ++ R+ +C
Sbjct: 1385 AAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPG 1444
Query: 1103 --IQKAPG-----------------------------ERLGISIRGGARGHAGNPRDPTD 1131
++ P + L + G G A + D T
Sbjct: 1445 NAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEED-TL 1503
Query: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
G+ I ++ G A DGRL+VG ++L V+ + ++G + + LL++ T+ + +
Sbjct: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 86.7 bits (213), Expect = 2e-16
Identities = 129/537 (24%), Positives = 210/537 (39%), Gaps = 107/537 (19%)
Query: 728 TLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGV 786
T+ ++ GLG I GGK + G+ + + G A + G + GD +L++
Sbjct: 257 TIELVNDGSGLGFGIIGGKAT--------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
Query: 787 ALQGAEHHEAVEALRGAGTAVQMRVWRERMVE--PENAVTITPLRPEDDYSPRERRGGGL 844
L G + + LR G V++ + R + E A+ IT L +P R
Sbjct: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGIT-LSSSPTSTPELRVDAST 367
Query: 845 RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAH 904
+ G + L ++ +GLG +IAG G + +GIFV I + A
Sbjct: 368 Q--------KGEESETFDVELTKNVQGLGITIAGYIGDK--KLEPSGIFVKSITKSSAVE 417
Query: 905 RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL-------EREAGGPLPPS 957
G +Q+GD++++++G ++ + AV +L T+ L L E E +
Sbjct: 418 HDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVT 477
Query: 958 PLPHSSPPTAAV------------ATTSITTATP-GVPGLPSLAPSLLAAALEGPYPVEE 1004
SP A++ ++T T P G P L+ + +E E
Sbjct: 478 KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEI--EEIEDAQKQEA 535
Query: 1005 IRLPRAGGPLGLS---IVGGSDHSSHPFGV---QEPGV---FISKVLPRGLAARSG-LRV 1054
L + +G++ +V S G+ E V FI VLP G SG L
Sbjct: 536 ALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFS 595
Query: 1055 GDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLR------ELC---IQK 1105
GD +L VNG + HQ+ V+ L +E++++ R PP + +LC + +
Sbjct: 596 GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
Query: 1106 AP----GERLG----------------------------------ISIRGGARG------ 1121
P GE +G I + G++G
Sbjct: 656 KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
Query: 1122 HAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
+P DP I I + P G A +DGRL G RL+ VN +L + EAV+ L+
Sbjct: 716 DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 84.3 bits (207), Expect = 9e-16
Identities = 98/416 (23%), Positives = 164/416 (39%), Gaps = 76/416 (18%)
Query: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 781
E E + + + GLGI+IAG G K + GIF+ +++ G +++GD+++
Sbjct: 372 ESETFDVELTKNVQGLGITIAGYIGDK--KLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
Query: 782 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSP----- 836
V+G LQG + +AVE LR G V + + R M + ++ + + D SP
Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489
Query: 837 --------RERRGGGLRLPLLPPESPG-PL-----------RQRHVACLARSER--GLGF 874
+ +LP E G PL +++ A L + +R G+ +
Sbjct: 490 IKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINY 549
Query: 875 SIAGGKGSTPYRAGDAGI---------FVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925
I S GI F+ + G +G L GD +L +NG+ +
Sbjct: 550 EIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLG 609
Query: 926 ARHDHAVSLLTAASPTIALLLEREAGGPLPPSPL-------------PH---------SS 963
H V++L + ++ R P S L PH S
Sbjct: 610 ENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSE 669
Query: 964 PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSD 1023
+A T +T V AP + A ++ I L + LG SI+ D
Sbjct: 670 TEDPVLAMTDAGQSTEEVQ-----APLAMWEA-----GIQHIELEKGSKGLGFSILDYQD 719
Query: 1024 HSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
P + I ++P G+A + G L GDR++ VN ++ +++ +EAV AL
Sbjct: 720 ----PIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL 771
Score = 65.1 bits (157), Expect = 5e-10
Identities = 86/319 (26%), Positives = 127/319 (39%), Gaps = 64/319 (20%)
Query: 664 EEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIE 723
EEEG P E EE E+ ++E A + + + G++++ I A +
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQR---------IMGINYE------IVVAHVS 557
Query: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLE 782
+ + GLGIS+ G FI V EGP +G + GD+LLE
Sbjct: 558 K-------FSENSGLGISLEATVGHH---------FIRSVLPEGPVGHSGKLFSGDELLE 601
Query: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPL---------RPEDD 833
VNG+ L G H + V L+ V M V R V P + L +P D
Sbjct: 602 VNGITLLGENHQDVVNILKELPIEVTM-VCCRRTVPPTTQSELDSLDLCDIELTEKPHVD 660
Query: 834 YSPRERRGGG-LRLPLLPPESPGPLRQRHVACLA------------RSERGLGFSIAGGK 880
E G P+L G + A LA + +GLGFSI +
Sbjct: 661 LG--EFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQ 718
Query: 881 GSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA-S 939
P I + + GG A + G L GDR++ +N V++ + + AV L A S
Sbjct: 719 --DPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPS 776
Query: 940 PTIALLLEREAGGPLPPSP 958
T+ + + + PLP SP
Sbjct: 777 GTVRIGVAK----PLPLSP 791
Score = 63.9 bits (154), Expect = 1e-09
Identities = 56/218 (25%), Positives = 97/218 (44%), Gaps = 46/218 (21%)
Query: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
V E+ P +GG LG S+VG + E G+F+ ++ +A R G L+ D+ILA
Sbjct: 137 VFELLKPPSGG-LGFSVVGLRSENRG-----ELGIFVQEIQEGSVAHRDGRLKETDQILA 190
Query: 1061 VNGQDV-RDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAP------------ 1107
+NGQ + + THQ+A+S L + + L++ R P + + + ++P
Sbjct: 191 INGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPI-VSRSPSAASTISAHSNP 249
Query: 1108 --------------GERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153
G LG I GG G+ + + P G A + GRL
Sbjct: 250 VHWQHMETIELVNDGSGLGFGIIGGKA-----------TGVIVKTILPGGVADQHGRLCS 298
Query: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG 1191
G +L++ L G++ + Q+LR G+ + +++ G
Sbjct: 299 GDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARG 336
Score = 51.2 bits (121), Expect = 8e-06
Identities = 30/88 (34%), Positives = 46/88 (52%), Gaps = 3/88 (3%)
Query: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
AGN +D + +FI + P GAAG+DGRL++ LLE+N Q L G +H A +++
Sbjct: 1365 AGN-KDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPS 1423
Query: 1183 TLTVLVCDGFEASTDAALEVSPGVIANP 1210
+ ++ +A A V PG P
Sbjct: 1424 KVKIIFIRNKDAVNQMA--VCPGNAVEP 1449
Score = 42.4 bits (98), Expect = 0.004
Identities = 22/55 (40%), Positives = 31/55 (56%)
Query: 1135 FISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189
FI V P G G G+L G LLEVN +LLG H + V +L+ + +T++ C
Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCC 631
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 149 bits (376), Expect = 2e-35
Identities = 156/545 (28%), Positives = 229/545 (42%), Gaps = 126/545 (23%)
Query: 738 LGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793
LGISI GG+ + E GIFI +V E+ PA + ++ GDK+LEV+GV LQ A H
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
Query: 794 HEAVEALRGAGT----AVQMRVWRERMVE--PENAVTITPLRPEDDYSPRERRGGGLRLP 847
EAVEA++ AG VQ R++ A IT + +D +E+R G P
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
Query: 848 L-LPPE-----------------SPGPLRQR--------HVACLARSERGLGFSIAGGKG 881
+ LPP + +RQR H+ L + + GLG S+AG K
Sbjct: 1199 MKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKD 1258
Query: 882 STPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPT 941
+ IFV I G A G +++GD +L IN + H +A +++ A
Sbjct: 1259 RS-----RMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSK 1313
Query: 942 IALLLEREAGG----PLPPSPLPHSSPP-------TAAVATTSITTATPGVPGLPSLAPS 990
+ L+ R + P P+P SSP T +++ + G+ LP
Sbjct: 1314 VKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESF 1373
Query: 991 LLAAA--------------------------------------LEGPYPVEEIRLPRAGG 1012
LA + + P V+ P G
Sbjct: 1374 KLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPG 1433
Query: 1013 P------------LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRIL 1059
LGLSIVGG D + + I +V G AAR G L GD+IL
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN-------AIVIHEVYEEGAAARDGRLWAGDQIL 1486
Query: 1060 AVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE------LCIQKAPGERLGI 1113
VNG D+R+++H+EA++AL + ++ L+V RD A E + +QK G LG+
Sbjct: 1487 EVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGL 1546
Query: 1114 SIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEA 1173
SI G G G+FIS + GAA DGRL G ++L VN + + +
Sbjct: 1547 SIVGKRNG----------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETV 1596
Query: 1174 VQLLR 1178
+L+
Sbjct: 1597 ATILK 1601
Score = 122 bits (306), Expect = 3e-27
Identities = 120/379 (31%), Positives = 177/379 (46%), Gaps = 67/379 (17%)
Query: 715 LLIEPAR---IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR 771
L ++PA + +E+ + I + GLG+SI GGK TP I I V EEG AAR
Sbjct: 1421 LSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGK-DTPLNA----IVIHEVYEEGAAAR 1475
Query: 772 AG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRP 830
G + GD++LEVNGV L+ + H EA+ ALR V++ V+R+
Sbjct: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD---------------- 1519
Query: 831 EDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDA 890
E Y E L + P V ++ RGLG SI G + +
Sbjct: 1520 EAHYRDEEN------LEIFP-----------VDLQKKAGRGLGLSIVGKRNGS------- 1555
Query: 891 GIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER-E 949
G+F+S I +GGAA G L GD++LS+NG D+ A + ++L A + L + R
Sbjct: 1556 GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLR 1615
Query: 950 AGGPLPPSPLPHSSPPTAAVATTSI-TTATPGVPGLPSLA-------PSLLAAALE-GPY 1000
AG +S + A +S + P + GL +L PS + + P
Sbjct: 1616 AGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPR 1675
Query: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRIL 1059
VE R LG+SI GG P G + VFI+ + G+AAR+ L+VGDRI+
Sbjct: 1676 TVEINR--ELSDALGISIAGG---RGSPLG--DIPVFIAMIQASGVAARTQKLKVGDRIV 1728
Query: 1060 AVNGQDVRDATHQEAVSAL 1078
++NGQ + +H + V+ L
Sbjct: 1729 SINGQPLDGLSHADVVNLL 1747
Score = 93.2 bits (230), Expect = 2e-18
Identities = 109/423 (25%), Positives = 174/423 (41%), Gaps = 98/423 (23%)
Query: 819 PENAVTITPLRP-------EDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERG 871
P N T++ L P ED S ++ G ++ + E P S G
Sbjct: 98 PSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERP-------------STGG 144
Query: 872 LGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE-ARHDH 930
LGFS+ + G IFV + G A R L+ D++L+IN + + H
Sbjct: 145 LGFSVVALRSQN---LGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
Query: 931 AVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990
A++LL + ++ L++ RE V T S T+++ LP
Sbjct: 202 AIALLQQTTGSLRLIVAREP------------------VHTKSSTSSSLNDTTLPE---- 239
Query: 991 LLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS 1050
G VEE+ L G LG IVGG + GV + ++P GLA R
Sbjct: 240 ---TVCWGH--VEEVELINDGSGLGFGIVGG----------KTSGVVVRTIVPGGLADRD 284
Query: 1051 G-LRVGDRILAVNGQDVRDATHQEAVSALLRPC-LELSLLVRRDPA------PPGLRELC 1102
G L+ GD IL + G +V+ T E V+ +LR C + +LV RDPA PP L
Sbjct: 285 GRLQTGDHILKIGGTNVQGMT-SEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALP 343
Query: 1103 I------QKAP------------------GERLGISIRGGARGHAGNPRDPTDEGIFISK 1138
+ K P G+ LGI I G+ G GI++
Sbjct: 344 VALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRI----VGYVGTSHTGEASGIYVKS 399
Query: 1139 VSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDA 1198
+ P AA +G ++V +++ V+ ++ G + + V++LR+ G + + + +S+ +
Sbjct: 400 IIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459
Query: 1199 ALE 1201
LE
Sbjct: 460 PLE 462
Score = 91.3 bits (225), Expect = 7e-18
Identities = 94/349 (26%), Positives = 149/349 (42%), Gaps = 57/349 (16%)
Query: 735 TGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AGVRVGDKLLEVNGVAL-QGAE 792
TGGLG S+ + K D IF+ V A R ++ D++L +N L Q
Sbjct: 142 TGGLGFSVVALRSQNLGKVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
Query: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPE 852
H +A+ L+ ++++ V RE P + + T D P G +
Sbjct: 199 HQQAIALLQQTTGSLRLIVARE----PVHTKSSTSSSLNDTTLPETVCWGHVE------- 247
Query: 853 SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
L GLGF I GGK S G+ V I GG A R G LQ G
Sbjct: 248 ---------EVELINDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTG 290
Query: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATT 972
D +L I G +V + +L ++ +L+ R+ G + +P P AA+
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTP-----PAPAALPVA 345
Query: 973 SITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFG 1030
T A+ G PG S +L Y VE +R + G LG+ IVG G+ H+
Sbjct: 346 LPTVASKG-PGSDS--------SLFETYNVELVR--KDGQSLGIRIVGYVGTSHTG---- 390
Query: 1031 VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
+ G+++ ++P A +G ++V D+I+AV+G +++ + + V L
Sbjct: 391 -EASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVL 438
Score = 82.4 bits (202), Expect = 3e-15
Identities = 74/270 (27%), Positives = 120/270 (44%), Gaps = 39/270 (14%)
Query: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
+EE EL + GLG I GGK S G+ + + G A R G ++ GD +
Sbjct: 246 VEEVEL----INDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTGDHI 293
Query: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
L++ G +QG + + LR G +V+M V R+ P +++TP P
Sbjct: 294 LKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----PAGDISVTPPAPA--------- 340
Query: 841 GGGLRLPLLPPESPGP----LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSR 896
+ LP + + PG +V + + + LG I G G T + +GI+V
Sbjct: 341 ALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVG-TSHTGEASGIYVKS 399
Query: 897 IAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER----EAGG 952
I G AA+ G +QV D++++++GV++ + V +L A + L L R +
Sbjct: 400 IIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459
Query: 953 PL-PPS---PLPHSSPPTAAVATTSITTAT 978
PL PPS + P A T ++ T T
Sbjct: 460 PLEPPSDRGTVVEPLKPPALFLTGAVETET 489
Score = 70.1 bits (170), Expect = 2e-11
Identities = 67/224 (29%), Positives = 96/224 (42%), Gaps = 26/224 (11%)
Query: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRV-GDKLLEVNGVALQGAEHHE 795
GLG+SI G K + G+FIS + + G A G + GD++L VNG ++ A
Sbjct: 1543 GLGLSIVG-------KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQET 1595
Query: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPR--------------ERRG 841
L+ A VQ+ + R R +A T + S +
Sbjct: 1596 VATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLV 1655
Query: 842 GGLRLPLLPPESPGP-LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
G R+ ++ G + R V LG SIAGG+GS GD +F++ I
Sbjct: 1656 GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSP---LGDIPVFIAMIQAS 1712
Query: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944
G A R L+VGDR++SING + H V+LL A I L
Sbjct: 1713 GVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIIL 1756
Score = 64.7 bits (156), Expect = 7e-10
Identities = 70/281 (24%), Positives = 106/281 (37%), Gaps = 55/281 (19%)
Query: 836 PRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTP-YRAGDA--GI 892
P G G P P R V LG SI GG+ + G+ GI
Sbjct: 1047 PEREEGEGEETPNFSHWGP----PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGI 1102
Query: 893 FVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL------ 946
F+ ++ E A + L+ GD++L ++GVD+ A H AV + A + ++
Sbjct: 1103 FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSST 1162
Query: 947 --------------------------EREAGGPLPPSPLPHSSPPTAAVATTSITTATPG 980
E+ G PP LP PP A+ T +
Sbjct: 1163 PRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLP---PPYKAL--TDDSDENEE 1217
Query: 981 VPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISK 1040
A L G + E+ + G LGLS+ G D S +F+
Sbjct: 1218 EDAFTDQKIRQRYADLPGELHIIELEKDKNG--LGLSLAGNKDRS-------RMSIFVVG 1268
Query: 1041 VLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLR 1080
+ P G AA G +R+GD +L +N Q + +HQ A SA+++
Sbjct: 1269 INPEGPAAADGRMRIGDELLEINNQILYGRSHQNA-SAIIK 1308
Score = 54.3 bits (129), Expect = 9e-07
Identities = 48/193 (24%), Positives = 87/193 (45%), Gaps = 39/193 (20%)
Query: 659 KEEEEEEEGS---------PQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSF 709
+E++E+ +G+ P + ++ +EN EEE+A T+++ ++
Sbjct: 1185 QEKKEKRQGTAPPPMKLPPPYKALTDDSDEN--EEEDAFTDQKIRQ-------------- 1228
Query: 710 DQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPA 769
A + E + + + GLG+S+AG K + IF+ ++ EGPA
Sbjct: 1229 --------RYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMS-----IFVVGINPEGPA 1275
Query: 770 ARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPL 828
A G +R+GD+LLE+N L G H A ++ A + V++ R + AVT P+
Sbjct: 1276 AADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPV 1335
Query: 829 RPEDDYSPRERRG 841
S ++ G
Sbjct: 1336 PSSSPSSIEDQSG 1348
Score = 51.6 bits (122), Expect = 6e-06
Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 7/104 (6%)
Query: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
R + I + + LGISI GG G D +FI+ + +G A R +L+VG R++
Sbjct: 1675 RTVEINRELSDALGISIAGGRGSPLG------DIPVFIAMIQASGVAARTQKLKVGDRIV 1728
Query: 1159 EVNQQSLLGLTHGEAVQLLRSV-GDTLTVLVCDGFEASTDAALE 1201
+N Q L GL+H + V LL++ G + +V D ++ A LE
Sbjct: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLE 1772
Score = 51.2 bits (121), Expect = 8e-06
Identities = 56/197 (28%), Positives = 80/197 (40%), Gaps = 21/197 (10%)
Query: 759 FISRVSEEGPAARAGV-RVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRE--- 814
+IS + GP G+ + D+LLEVNG+ L G EAV L+ + R
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 815 ---RMVEPENAVTITPLRPED---DYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARS 868
+ EP T P D D + E G L L PE + L +
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDG--ELALWSPEV-------KIVELVKD 692
Query: 869 ERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARH 928
+GLGFSI + P + I + + G A R+G L GDR++S+N +
Sbjct: 693 CKGLGFSILDYQ--DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSL 750
Query: 929 DHAVSLLTAASPTIALL 945
AV +L A P + L
Sbjct: 751 AEAVEILKAVPPGLVHL 767
Score = 51.2 bits (121), Expect = 8e-06
Identities = 32/104 (30%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
Query: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182
AGN +D + IF+ ++P G A DGR+R+G LLE+N Q L G +H A ++++
Sbjct: 1254 AGN-KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312
Query: 1183 TLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISS 1226
+ ++ +A A V+P + + + I ++ E ISS
Sbjct: 1313 KVKLVFIRNEDAVNQMA--VTPFPVPSSSPSSIEDQSGTEPISS 1354
Score = 51.2 bits (121), Expect = 8e-06
Identities = 37/117 (31%), Positives = 62/117 (52%), Gaps = 9/117 (7%)
Query: 701 APSVKGVSFDQANNLLIEPAR----IEEEELTLTILRQ-TGGLGISIAGGKGSTPYKGDD 755
AP + G+ + +P++ + E T+ I R+ + LGISIAGG+GS D
Sbjct: 1645 APVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL---GD 1701
Query: 756 EGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRV 811
+FI+ + G AAR ++VGD+++ +NG L G H + V L+ A + ++V
Sbjct: 1702 IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQV 1758
Score = 48.1 bits (113), Expect = 7e-05
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 11/115 (9%)
Query: 1095 PPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVG 1154
PP + E I + P LGISI GG +GIFI +V AG+ L+ G
Sbjct: 1065 PPRIVE--IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTG 1122
Query: 1155 LRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIAN 1209
++LEV+ L +H EAV+ +++ G+ + +V +L +P VI N
Sbjct: 1123 DKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIV---------QSLSSTPRVIPN 1168
Score = 45.1 bits (105), Expect = 6e-04
Identities = 57/222 (25%), Positives = 81/222 (36%), Gaps = 33/222 (14%)
Query: 889 DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER 948
D ++S I GG G LQ D +L +NG+ + AVS L P L+ R
Sbjct: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
Query: 949 ----EAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEE 1004
+ P S P T + T L +P V+
Sbjct: 638 RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE-----------VKI 686
Query: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRILAVNG 1063
+ L + LG SI+ D P + I ++ G+A RS GL GDR+++VN
Sbjct: 687 VELVKDCKGLGFSILDYQD----PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
Query: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQK 1105
+ + + EAV L PPGL L I K
Sbjct: 743 YCLDNTSLAEAVEIL-------------KAVPPGLVHLGICK 771
Score = 37.7 bits (86), Expect = 0.092
Identities = 22/56 (39%), Positives = 31/56 (55%)
Query: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSV 1180
+P DPT I I + G A R G L G RL+ VN+ L + EAV++L++V
Sbjct: 705 DPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
Score = 32.7 bits (73), Expect = 2.9
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 3/73 (4%)
Query: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
D D +IS + G G L+ LLEVN L G + EAV L+ V T++
Sbjct: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
Query: 1188 VCDGF---EASTD 1197
C EAS D
Sbjct: 635 CCRRLFDDEASVD 647
Score = 32.7 bits (73), Expect = 2.9
Identities = 35/142 (24%), Positives = 54/142 (38%), Gaps = 25/142 (17%)
Query: 661 EEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPA 720
++E P+ E E + +TEE+D + +P VK V
Sbjct: 641 DDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVE------------ 688
Query: 721 RIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRVGDK 779
+++ GLG SI + P I I + +G A R+ G+ GD+
Sbjct: 689 ----------LVKDCKGLGFSILDYQ--DPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 780 LLEVNGVALQGAEHHEAVEALR 801
L+ VN L EAVE L+
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILK 758
>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
Length = 817
Score = 148 bits (373), Expect = 5e-35
Identities = 128/390 (32%), Positives = 187/390 (47%), Gaps = 73/390 (18%)
Query: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
EE+ L R GLG SIAGG + P+ DD GIFI+++ G AA G + V D +L V
Sbjct: 130 EEIVLE--RGNSGLGFSIAGGIDN-PHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
Query: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843
N V + H AVEAL+ AG V++ V R R PE + + L+
Sbjct: 187 NEVDVSEVVHSRAVEALKEAGPVVRLVV-RRRQPPPETIMEVNLLK-------------- 231
Query: 844 LRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAA 903
GP +GLGFSIAGG G+ + GD I++++I EGGAA
Sbjct: 232 -----------GP-------------KGLGFSIAGGIGNQ-HIPGDNSIYITKIIEGGAA 266
Query: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSS 963
+ G LQ+GDR+L++N ++ + RH+ AV+ L S + L + + L P
Sbjct: 267 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDY 326
Query: 964 PPT-AAVATTSIT--------------TATPGVPGLP----SLAPSLLAAALEGPYPVEE 1004
T A+A I+ + P P +P S P + A + +
Sbjct: 327 ASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRK 386
Query: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
I L + LG +IVGG D G+F+S +L G A SG LR GDRIL+VNG
Sbjct: 387 IILHKGSTGLGFNIVGGEDGE---------GIFVSFILAGGPADLSGELRRGDRILSVNG 437
Query: 1064 QDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
++R+ATH++A +AL R ++++ + P
Sbjct: 438 VNLRNATHEQAAAALKRAGQSVTIVAQYRP 467
Score = 128 bits (322), Expect = 4e-29
Identities = 104/301 (34%), Positives = 144/301 (47%), Gaps = 40/301 (13%)
Query: 952 GPLPPSPLPHSSPPTAAVATTSITTATPGVPGL-PSLAPSLLAA---------ALEGPYP 1001
GP+PP P+P S TP + G PS P +G +
Sbjct: 83 GPVPPKPVPGKS--------------TPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFK 128
Query: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
EEI L R LG SI GG D+ P +PG+FI+K++P G AA G L V D +L
Sbjct: 129 YEEIVLERGNSGLGFSIAGGIDNPHVP---DDPGIFITKIIPGGAAAMDGRLGVNDCVLR 185
Query: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRR-DPAPPGLRELCIQKAPGERLGISIRGGA 1119
VN DV + H AV AL + L+VRR P P + E+ + K P + LG SI GG
Sbjct: 186 VNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGP-KGLGFSIAGGI 244
Query: 1120 RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
GN P D I+I+K+ GAA +DGRL++G RLL VN +L + H EAV L++
Sbjct: 245 ----GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKN 300
Query: 1180 VGDTLTVLVCDGFEASTDAALEVSPGVIANPFAA----GIGHRNSLESISSIDRELSPEG 1235
D + + V S +P A+ F A I H +SL + +++ ++S
Sbjct: 301 TSDMVYLKVAK--PGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPA 358
Query: 1236 P 1236
P
Sbjct: 359 P 359
Score = 105 bits (262), Expect = 4e-22
Identities = 79/253 (31%), Positives = 122/253 (48%), Gaps = 39/253 (15%)
Query: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLE 782
E + + +L+ GLG SIAGG G+ GD+ I+I+++ E G A + G +++GD+LL
Sbjct: 222 ETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNS-IYITKIIEGGAAQKDGRLQIGDRLLA 280
Query: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWR-------ERMVEPENAVTITPLRPEDDYS 835
VN LQ H EAV +L+ V ++V + + P+ A T T L D++
Sbjct: 281 VNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTAL--ADNHI 338
Query: 836 PRERRGGGLRL----------PLLPPESPGPL-----------RQRHVACLARSERGLGF 874
G L P +PP P+ R+ L + GLGF
Sbjct: 339 SHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGF 398
Query: 875 SIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSL 934
+I GG+ GIFVS I GG A +G L+ GDR+LS+NGV++ A H+ A +
Sbjct: 399 NIVGGEDG-------EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAA 451
Query: 935 LTAASPTIALLLE 947
L A ++ ++ +
Sbjct: 452 LKRAGQSVTIVAQ 464
Score = 87.4 bits (215), Expect = 1e-16
Identities = 92/338 (27%), Positives = 135/338 (39%), Gaps = 24/338 (7%)
Query: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
L R GLGFSIAGG + P+ D GIF+++I GGAA G L V D VL +N VDV+
Sbjct: 134 LERGNSGLGFSIAGGIDN-PHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVS 192
Query: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
E H AV L A P + L++ R P + P + + +PG
Sbjct: 193 EVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGD 252
Query: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSD--HSSHPFGVQEPG--VFISK 1040
S+ + +EG ++ RL L ++ D H ++ V++
Sbjct: 253 NSI---YITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309
Query: 1041 VLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRE 1100
P L D +H ++ L ++S PAPP +
Sbjct: 310 AKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSY-----PAPPQVPP 364
Query: 1101 LCIQKAPGERLG----------ISIRGGARGHAGNPRDPTD-EGIFISKVSPTGAAGRDG 1149
P L I + G+ G N D EGIF+S + G A G
Sbjct: 365 TRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSG 424
Query: 1150 RLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
LR G R+L VN +L TH +A L+ G ++T++
Sbjct: 425 ELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
Score = 57.4 bits (137), Expect = 1e-07
Identities = 36/92 (39%), Positives = 54/92 (58%), Gaps = 13/92 (14%)
Query: 722 IEEEELT-----LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VR 775
+ EE+ T + + + + GLG +I GG+ D EGIF+S + GPA +G +R
Sbjct: 375 LAEEDFTREPRKIILHKGSTGLGFNIVGGE-------DGEGIFVSFILAGGPADLSGELR 427
Query: 776 VGDKLLEVNGVALQGAEHHEAVEALRGAGTAV 807
GD++L VNGV L+ A H +A AL+ AG +V
Sbjct: 428 RGDRILSVNGVNLRNATHEQAAAALKRAGQSV 459
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 147 bits (371), Expect = 8e-35
Identities = 96/268 (35%), Positives = 138/268 (51%)
Query: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
H+ +D H L A+ E+ R L +L L NQL LP L +L +L +S N +
Sbjct: 112 HLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
Query: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
LP ++ +L LDV N + P + ALE D S N L LP+ + LR+L
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
Query: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDT 192
L L+ L LP LA+L +L L N L++LPA S L +L+ L+L N E P
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
Query: 193 LGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQ 252
L L L EL+L RNQL+++P + L RL+ L + NR+ LP + L L +L+L
Sbjct: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
Query: 253 NLLRRLPDGIGQLKQLSILKVDQNRLCE 280
N + LPD GQL ++ + K+ N L +
Sbjct: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQ 379
Score = 144 bits (363), Expect = 7e-34
Identities = 113/313 (36%), Positives = 150/313 (47%), Gaps = 7/313 (2%)
Query: 79 ANFMQLVELDVSRNDIPEIPESI-KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALND 137
AN + L++ N + E+PE + +L + N +RLP +L HL D
Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGH--HLTELD 117
Query: 138 VS---LQALPGDVGN-LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
VS L AL +V + L L L L N L +LPA L L LE+LD+ N L LPD+L
Sbjct: 118 VSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSL 177
Query: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
L LR L +D NQL+A P +L L L LDVS NRL LP ++ L L L LS
Sbjct: 178 SCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGA 237
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
L LP G +L L L +D N L + + L L L+ NL P +L L
Sbjct: 238 ELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAG 297
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
L L + RN L ++P I G L L L +NR+ LP + T L L + GN++ L
Sbjct: 298 LEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVL 357
Query: 374 PFALTHLNLKALW 386
P L+ LW
Sbjct: 358 PDHFGQLSRVGLW 370
Score = 144 bits (362), Expect = 9e-34
Identities = 107/320 (33%), Positives = 163/320 (50%), Gaps = 2/320 (0%)
Query: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRL-LNLRKLGLSDNEIQ 72
+E+++ + L+ VPE + SL L+L N+ LP L +L +L +S N +
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 73 RLPPEVANFM-QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLA 131
L EV + + +L +L++S N +P +P + LE D S N L+ LPD + L L
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
Query: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPD 191
L ++ L A P + L L L++ N L+ LP +S L L+ L L G +L LP
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
Query: 192 TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
L +L L LD N L ALP + L+RL L++S N EE PA L L L +L LS
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304
Query: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL 311
+N L +P I L +L L +D NR+ + ++I + L EL+L N + LP G+L
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
Query: 312 TKLTNLNVDRNHLEALPPEI 331
+++ + N L P E+
Sbjct: 365 SRVGLWKIKDNPLIQPPYEV 384
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 145 bits (366), Expect = 3e-34
Identities = 164/624 (26%), Positives = 262/624 (41%), Gaps = 112/624 (17%)
Query: 656 RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVV--------SAPSVKGV 707
R Q E+ + P+ E E E+ ++ E+ G V+ ++P+ V
Sbjct: 122 RYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV 181
Query: 708 SFDQANNL-LIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
+ D + + + IE E +T+ R GLG SIAGG + P+ GDD GIFI+++
Sbjct: 182 NTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPG 240
Query: 767 GPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTI 825
G AA G +RV D +L VN V + H +AVEAL+ AG+ V++ V R R + E V I
Sbjct: 241 GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-ETVVEI 299
Query: 826 TPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPY 885
L + +GLGFSIAGG G+ +
Sbjct: 300 K--------------------------------------LFKGPKGLGFSIAGGVGNQ-H 320
Query: 886 RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
GD I+V++I +GGAA + G LQVGDR+L +N + E H+ AV++L S + L
Sbjct: 321 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 380
Query: 946 LEREAG----GPLPPSPLPHS-SPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
+ + P P + HS SPP + LP ++P G Y
Sbjct: 381 VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP--------GRY 432
Query: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG-DRIL 1059
P+ ++ D++ P V ++K+ + + R V D+
Sbjct: 433 -----------SPIPKHMLVDDDYTRPPEPVYST---VNKLCDKPASPRHYSPVECDKSF 478
Query: 1060 AVNGQ----------DVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGE 1109
++ D +H + +A +P + L V + P R++ + K
Sbjct: 479 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-ST 534
Query: 1110 RLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
LG +I GG G EGIF+S + G A G L+ G ++L VN L G +
Sbjct: 535 GLGFNIVGGEDG----------EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584
Query: 1170 HGEAVQLLRSVGDTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLES 1223
H +A L+ G T+T++ FEA ++ ++ + ++G G + +
Sbjct: 585 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH---DLREQMMNHSMSSGSGSLRTNQK 641
Query: 1224 ISSIDRELSPEGPGKEKELPGQTL 1247
S R + K+ LP Q L
Sbjct: 642 RSLYVRAMFDYDKSKDSGLPSQGL 665
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 145 bits (366), Expect = 3e-34
Identities = 164/624 (26%), Positives = 262/624 (41%), Gaps = 112/624 (17%)
Query: 656 RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVV--------SAPSVKGV 707
R Q E+ + P+ E E E+ ++ E+ G V+ ++P+ V
Sbjct: 17 RYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV 76
Query: 708 SFDQANNL-LIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
+ D + + + IE E +T+ R GLG SIAGG + P+ GDD GIFI+++
Sbjct: 77 NTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPG 135
Query: 767 GPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTI 825
G AA G +RV D +L VN V + H +AVEAL+ AG+ V++ V R R + E V I
Sbjct: 136 GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-ETVVEI 194
Query: 826 TPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPY 885
L + +GLGFSIAGG G+ +
Sbjct: 195 K--------------------------------------LFKGPKGLGFSIAGGVGNQ-H 215
Query: 886 RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
GD I+V++I +GGAA + G LQVGDR+L +N + E H+ AV++L S + L
Sbjct: 216 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 275
Query: 946 LEREAG----GPLPPSPLPHS-SPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
+ + P P + HS SPP + LP ++P G Y
Sbjct: 276 VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP--------GRY 327
Query: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG-DRIL 1059
P+ ++ D++ P V ++K+ + + R V D+
Sbjct: 328 -----------SPIPKHMLVDDDYTRPPEPVYST---VNKLCDKPASPRHYSPVECDKSF 373
Query: 1060 AVNGQ----------DVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGE 1109
++ D +H + +A +P + L V + P R++ + K
Sbjct: 374 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-ST 429
Query: 1110 RLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
LG +I GG G EGIF+S + G A G L+ G ++L VN L G +
Sbjct: 430 GLGFNIVGGEDG----------EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479
Query: 1170 HGEAVQLLRSVGDTLTVLV------CDGFEASTDAALEVSPGVIANPFAAGIGHRNSLES 1223
H +A L+ G T+T++ FEA ++ ++ + ++G G + +
Sbjct: 480 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH---DLREQMMNHSMSSGSGSLRTNQK 536
Query: 1224 ISSIDRELSPEGPGKEKELPGQTL 1247
S R + K+ LP Q L
Sbjct: 537 RSLYVRAMFDYDKSKDSGLPSQGL 560
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 138 bits (347), Expect = 5e-32
Identities = 114/381 (29%), Positives = 194/381 (50%), Gaps = 12/381 (3%)
Query: 86 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLS-RLPDGFTQLRSLAHLALNDVSLQALP 144
+L++S ++ E+P+ + ++I + + LS + + + L L +++ LQ+L
Sbjct: 40 QLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLT 98
Query: 145 GDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204
D+ L L L++ +N L SLP+++ L L++L++ N L++LP+ + L NL+ L+L
Sbjct: 99 DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYL 158
Query: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
N+L+ + L L LD+S N L +PA L L L LS N L+ LP I +
Sbjct: 159 QHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINR 218
Query: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
+K+L L + N L + + E+L L L N L LP + L L+V N +
Sbjct: 219 MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQI 277
Query: 325 EALPPE-IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLK 383
E L E + ++ VL LRDN+L +P E+ L LD++ N + SLP++L +L+LK
Sbjct: 278 EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLK 337
Query: 384 ALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAP-P 442
L L N P+ + E ++ ++VL YL + + + Q S +ET P
Sbjct: 338 FLALEGN---PLRTIRREIISKGTQEVLK-YL---RSKIKDDGPSQSESATETAMTLPSE 390
Query: 443 SRVSVIQFLEAPIGDEDAEEA 463
SRV++ + I D ++A
Sbjct: 391 SRVNIHAIITLKILDYSDKQA 411
Score = 129 bits (325), Expect = 2e-29
Identities = 100/352 (28%), Positives = 169/352 (48%), Gaps = 13/352 (3%)
Query: 26 AVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFM--- 82
+VP+ + + +R +L L L E+P+ +R+ + + + Q L
Sbjct: 26 SVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRI----NVDIPEEANQNLSFGATERWWEQ 81
Query: 83 -QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQ 141
L +L +S N + + + ++ AL + D N L+ LP +L +L L ++ L+
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 142 ALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRE 201
LP ++ NL NL L L+ N L + L LE LDL N L +P + +L +L
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 202 LWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDG 261
L L N+L +LP E+ ++RL LD + N LE +P EL G+ L L L +N LR LP+
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE- 260
Query: 262 IGQLKQLSILKVDQNRLCEVTEA--IGDCENLSELILTENLLMALPRSLGKLTKLTNLNV 319
L L V +N++ E+ EA + ++ L L +N L ++P + L L L++
Sbjct: 261 FPSCSLLKELHVGENQI-EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDL 319
Query: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQ 371
N + +LP +G + L L+L N L + E+ VL ++++
Sbjct: 320 SNNDISSLPYSLGN-LHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIK 370
Score = 127 bits (320), Expect = 7e-29
Identities = 112/397 (28%), Positives = 197/397 (49%), Gaps = 28/397 (7%)
Query: 2 LKCIPLWRCN-RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
LK +P N R+++ + +H L + E + S +LE+L L N L +P F L +
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLS-NLEDLDLSNNHLTTVPASFSSLSS 198
Query: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
L +L LS NE++ LP E+ +L LD + N + IP + ++LE+ N L L
Sbjct: 199 LVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFL 258
Query: 121 PDGFTQLRSLAHLALNDVSLQALPGD-VGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
P+ F L L + + ++ L + + +L +++ L+LR+N LKS+P + L LE+L
Sbjct: 259 PE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERL 317
Query: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE----- 234
DL ND+ LP +LG L +L+ L L+ N L + E+ + L +++++
Sbjct: 318 DLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQ 376
Query: 235 ----------LPAE----LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSI---LKVDQNR 277
LP+E + ++ L L S +PD + + +I + +N+
Sbjct: 377 SESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQ 436
Query: 278 LCEVTEAIGDC-ENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336
LCE+ + + + E +S++ L+ N L + L L KLT L++ N L +LP E+ V
Sbjct: 437 LCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496
Query: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
L ++L NR +LP L L + ++ N++ S+
Sbjct: 497 LQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSV 533
Score = 108 bits (271), Expect = 3e-23
Identities = 105/407 (25%), Positives = 175/407 (42%), Gaps = 72/407 (17%)
Query: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
++E +D + L VP S SL L L +N+L+ LP R+ L+ L + N ++
Sbjct: 175 NLEDLDLSNNHLTTVPASFSSLS-SLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233
Query: 73 RLPPEVANFMQLVELDVSRNDI---PEIP--------------------ESIKFCKALEI 109
+PPE+A L L + RN + PE P E +K ++ +
Sbjct: 234 TIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
Query: 110 ADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKS---- 165
D N L +PD LRSL L L++ + +LP +GNL +L L L N L++
Sbjct: 294 LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRRE 352
Query: 166 ----------------------------------LPA----SLSFLVKLEQLDLGGNDLE 187
LP+ ++ ++ L+ LD
Sbjct: 353 IISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQAT 412
Query: 188 VLPDTL--GALPNL-RELWLDRNQLSALPPELGNLRRLVC-LDVSENRLEELPAELGGLV 243
++PD + N+ + +NQL +P + L+ +V +D+S N+L + EL L
Sbjct: 413 LIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQ 472
Query: 244 LLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMA 303
LT L L N L LP+ + L +L + + NR + E + L ++++ N + +
Sbjct: 473 KLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532
Query: 304 L-PRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAV 349
+ P+ + + LT L++ N L +PPE+G CV L L L N V
Sbjct: 533 VDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 579
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 126 bits (316), Expect = 2e-28
Identities = 112/349 (32%), Positives = 158/349 (45%), Gaps = 9/349 (2%)
Query: 28 PEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVEL 87
PE + + SL L L+ L LP+ L L L +S N + L E+++ L +
Sbjct: 26 PENV-KAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAI 84
Query: 88 DVSRNDIPE--IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
N + +P+ I L + D S N L+ P +++ L L+ S+ +P
Sbjct: 85 VARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPN 144
Query: 146 DVG-NLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL-EVLPDTLGALPNLRELW 203
+ NL +L+ L+L EN L+SLP + LV L+ L L GN L L A+ L+ L
Sbjct: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLH 204
Query: 204 LDRNQL--SALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDG 261
L Q S LP L L L +D+S N L +P L L L L LS N + L
Sbjct: 205 LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLC 264
Query: 262 IGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM--ALPRSLGKLTKLTNLNV 319
I Q + L + +N+L + AI L +L L N L LP +GKLT L
Sbjct: 265 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 324
Query: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
N+LE +P + C L L L N L LP + TE+ VLDV N
Sbjct: 325 ANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
Score = 125 bits (314), Expect = 3e-28
Identities = 102/307 (33%), Positives = 151/307 (49%), Gaps = 18/307 (5%)
Query: 37 SLEELLLDANQLRE--LPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDI 94
SL ++ AN L+ +P F+L +L L LS N++ P E+ N ++ L++S N I
Sbjct: 80 SLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSI 139
Query: 95 PEIPESIKFCKALEIA--DFSGNPLSRLPDGFTQLRSLAHLALND-----VSLQALPGDV 147
IP + F ++ D S N L LP +L L L LN L+ LP
Sbjct: 140 DTIPNQL-FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA-- 196
Query: 148 GNLANLVTLELR--ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
+ L TL LR + +LP SL L L +DL NDL +P+ L LP+LR L L
Sbjct: 197 --MTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLS 254
Query: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL--RRLPDGIG 263
NQ++ L + + L++S N+L LP+ + L L L L+ N L LP GIG
Sbjct: 255 SNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIG 314
Query: 264 QLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNH 323
+L L N L V E++ C L +L+L +N L+ LP ++ LT++ L+V N
Sbjct: 315 KLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENP 374
Query: 324 LEALPPE 330
+PP+
Sbjct: 375 NLVMPPK 381
Score = 108 bits (269), Expect = 6e-23
Identities = 99/320 (30%), Positives = 154/320 (48%), Gaps = 15/320 (4%)
Query: 87 LDVSRNDIPE--IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALP 144
+D+S ND PE++K +L + L LP+ L+ L HL+++ +L L
Sbjct: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
Query: 145 GDVGNLANLVTLELRENLLKS--LPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
G++ +L +L + R N LK+ +P + L L LDL N L P L N+ L
Sbjct: 73 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132
Query: 203 WLDRNQLSALPPELG-NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN-----LLR 256
L N + +P +L NL L+ LD+SENRLE LP ++ LV L L+L+ N LR
Sbjct: 133 NLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLR 192
Query: 257 RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTN 316
+LP + L+ L L+ Q + ++ NL+++ L+ N L +P L L L
Sbjct: 193 QLP-AMTALQTLH-LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRR 250
Query: 317 LNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRL--QSLP 374
LN+ N + L I V + L+L N+L LP + ++L L + N+L LP
Sbjct: 251 LNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLP 310
Query: 375 FALTHL-NLKALWLAENQAQ 393
+ L NL+ A N +
Sbjct: 311 SGIGKLTNLEEFMAANNNLE 330
Score = 90.5 bits (223), Expect = 1e-17
Identities = 75/260 (28%), Positives = 124/260 (47%), Gaps = 15/260 (5%)
Query: 7 LWRCNRHVES------VDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
L C R +E+ ++ H S+ +P +++ L L L N+L LP RL++
Sbjct: 116 LTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVH 175
Query: 61 LRKLGLSDN-----EIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGN 115
L+ L L+ N ++++LP A +Q + L ++ +P S++ L D S N
Sbjct: 176 LQTLVLNGNPLLHAQLRQLPAMTA--LQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCN 233
Query: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK 175
L+R+P+ L SL L L+ + L + ++ TL L N L SLP+++ L K
Sbjct: 234 DLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSK 293
Query: 176 LEQLDLGGN--DLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLE 233
L++L L N D + LP +G L NL E N L +P L +L L +++N L
Sbjct: 294 LKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLV 353
Query: 234 ELPAELGGLVLLTDLLLSQN 253
LP + L + L + +N
Sbjct: 354 TLPEAIHFLTEIEVLDVREN 373
Score = 33.5 bits (75), Expect = 1.7
Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 653 WAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEE 692
W P + EEEE++E ++ E +E EE AE EE EE+
Sbjct: 941 WVP-VEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEED 979
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 121 bits (304), Expect = 5e-27
Identities = 98/316 (31%), Positives = 160/316 (50%), Gaps = 12/316 (3%)
Query: 50 ELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE-----IPESIKFC 104
E P F NLR L + +I+ +P + + L EL ++ N E + + ++
Sbjct: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543
Query: 105 KALEIADFSGNPLSRLPDGFTQLR-SLAHLALNDVSLQALP-GDVGNLANLVTLELRENL 162
K L++ N LS+LP T + L L++N+ + + + +ANL LEL
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602
Query: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLR 220
L+ +P S+ L L+++DL N+L+ + + + L L L L N ++ +P ++GNL
Sbjct: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662
Query: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
L L ++ N++E++P +L L L LS N L LP IG L+ L L + NR+
Sbjct: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
Query: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--S 338
+ + C L L L N+L +LP +G+LT LT + + N LE LP E+G C L S
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782
Query: 339 VLSLRDNRLAVLPPEL 354
L + ++ LPPE+
Sbjct: 783 GLVVEEDLFNTLPPEV 798
Score = 112 bits (280), Expect = 3e-24
Identities = 105/364 (28%), Positives = 163/364 (44%), Gaps = 35/364 (9%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
L +P+ ++ LE L L+ +P +L L++L L + P +A +
Sbjct: 435 LSGIPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493
Query: 84 -LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR-----LPDGFTQLRSLAHLALND 137
L L + DI EIP I K LE +GN + + DG +L+ L L L
Sbjct: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553
Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
+L LP V ++ +L L + K + SL + L +L+L DLE +P ++ +
Sbjct: 554 -NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS 612
Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
L NL+E+ L N L + + +L RL CL + N + +P ++G L L L L++N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
+ ++P + C L L L+ N L LP +G L
Sbjct: 673 KIEKIPTQLFY-----------------------CRKLRYLDLSHNNLTFLPADIGLLQN 709
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
L NL + N +E LPPE+ C L L L +N L LP + T L +++ GNRL+ L
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
Query: 374 PFAL 377
P L
Sbjct: 770 PVEL 773
Score = 104 bits (260), Expect = 6e-22
Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 14/274 (5%)
Query: 2 LKCIPLWRCNRHVESVDKRHCSLQAVPE-------EIYRYSRSLEELLLDANQLRELPKP 54
+K IPLW + ++++++ H + E + R + L+ L L +N L +LP+
Sbjct: 505 IKEIPLWIYS--LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQV 561
Query: 55 FFRL-LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADF 112
+ ++L+KL +++ + + + L EL++ R D+ IP SI L+ D
Sbjct: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621
Query: 113 SGNPLSRLPD--GFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
N L + + F L L L L + +P +GNL NL L L N ++ +P L
Sbjct: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681
Query: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
+ KL LDL N+L LP +G L NL+ L + N++ LPPEL R+L L + N
Sbjct: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
Query: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
L+ LP+ +G L LT + L N L LP +G+
Sbjct: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
Score = 100 bits (248), Expect = 2e-20
Identities = 66/199 (33%), Positives = 105/199 (52%), Gaps = 5/199 (2%)
Query: 22 CSLQAVPEEIYRYSRSLEELLLDANQLRELPK--PFFRLLNLRKLGLSDNEIQRLPPEVA 79
C L+ +P I+ +L+E+ L N L+ + + F L L L L N I +P ++
Sbjct: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 80 NFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139
N L L ++RN I +IP + +C+ L D S N L+ LP L++L +LA+
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199
++ LP ++ L L L N+L+SLP+ + L L Q++L GN LE LP LG P L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 200 RE--LWLDRNQLSALPPEL 216
+ L ++ + + LPPE+
Sbjct: 780 KRSGLVVEEDLFNTLPPEV 798
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 121 bits (304), Expect = 5e-27
Identities = 98/316 (31%), Positives = 160/316 (50%), Gaps = 12/316 (3%)
Query: 50 ELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE-----IPESIKFC 104
E P F NLR L + +I+ +P + + L EL ++ N E + + ++
Sbjct: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543
Query: 105 KALEIADFSGNPLSRLPDGFTQLR-SLAHLALNDVSLQALP-GDVGNLANLVTLELRENL 162
K L++ N LS+LP T + L L++N+ + + + +ANL LEL
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602
Query: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLR 220
L+ +P S+ L L+++DL N+L+ + + + L L L L N ++ +P ++GNL
Sbjct: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662
Query: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
L L ++ N++E++P +L L L LS N L LP IG L+ L L + NR+
Sbjct: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
Query: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--S 338
+ + C L L L N+L +LP +G+LT LT + + N LE LP E+G C L S
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782
Query: 339 VLSLRDNRLAVLPPEL 354
L + ++ LPPE+
Sbjct: 783 GLVVEEDLFNTLPPEV 798
Score = 112 bits (280), Expect = 3e-24
Identities = 105/364 (28%), Positives = 163/364 (44%), Gaps = 35/364 (9%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
L +P+ ++ LE L L+ +P +L L++L L + P +A +
Sbjct: 435 LSGIPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493
Query: 84 -LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR-----LPDGFTQLRSLAHLALND 137
L L + DI EIP I K LE +GN + + DG +L+ L L L
Sbjct: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553
Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
+L LP V ++ +L L + K + SL + L +L+L DLE +P ++ +
Sbjct: 554 -NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS 612
Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
L NL+E+ L N L + + +L RL CL + N + +P ++G L L L L++N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
+ ++P + C L L L+ N L LP +G L
Sbjct: 673 KIEKIPTQLFY-----------------------CRKLRYLDLSHNNLTFLPADIGLLQN 709
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
L NL + N +E LPPE+ C L L L +N L LP + T L +++ GNRL+ L
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
Query: 374 PFAL 377
P L
Sbjct: 770 PVEL 773
Score = 104 bits (260), Expect = 6e-22
Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 14/274 (5%)
Query: 2 LKCIPLWRCNRHVESVDKRHCSLQAVPE-------EIYRYSRSLEELLLDANQLRELPKP 54
+K IPLW + ++++++ H + E + R + L+ L L +N L +LP+
Sbjct: 505 IKEIPLWIYS--LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQV 561
Query: 55 FFRL-LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADF 112
+ ++L+KL +++ + + + L EL++ R D+ IP SI L+ D
Sbjct: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621
Query: 113 SGNPLSRLPD--GFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
N L + + F L L L L + +P +GNL NL L L N ++ +P L
Sbjct: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681
Query: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
+ KL LDL N+L LP +G L NL+ L + N++ LPPEL R+L L + N
Sbjct: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
Query: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
L+ LP+ +G L LT + L N L LP +G+
Sbjct: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
Score = 100 bits (248), Expect = 2e-20
Identities = 66/199 (33%), Positives = 105/199 (52%), Gaps = 5/199 (2%)
Query: 22 CSLQAVPEEIYRYSRSLEELLLDANQLRELPK--PFFRLLNLRKLGLSDNEIQRLPPEVA 79
C L+ +P I+ +L+E+ L N L+ + + F L L L L N I +P ++
Sbjct: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 80 NFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139
N L L ++RN I +IP + +C+ L D S N L+ LP L++L +LA+
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199
++ LP ++ L L L N+L+SLP+ + L L Q++L GN LE LP LG P L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 200 RE--LWLDRNQLSALPPEL 216
+ L ++ + + LPPE+
Sbjct: 780 KRSGLVVEEDLFNTLPPEV 798
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 121 bits (304), Expect = 5e-27
Identities = 98/316 (31%), Positives = 160/316 (50%), Gaps = 12/316 (3%)
Query: 50 ELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE-----IPESIKFC 104
E P F NLR L + +I+ +P + + L EL ++ N E + + ++
Sbjct: 484 EAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543
Query: 105 KALEIADFSGNPLSRLPDGFTQLR-SLAHLALNDVSLQALP-GDVGNLANLVTLELRENL 162
K L++ N LS+LP T + L L++N+ + + + +ANL LEL
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD 602
Query: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLR 220
L+ +P S+ L L+++DL N+L+ + + + L L L L N ++ +P ++GNL
Sbjct: 603 LERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT 662
Query: 221 RLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
L L ++ N++E++P +L L L LS N L LP IG L+ L L + NR+
Sbjct: 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIET 722
Query: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--S 338
+ + C L L L N+L +LP +G+LT LT + + N LE LP E+G C L S
Sbjct: 723 LPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRS 782
Query: 339 VLSLRDNRLAVLPPEL 354
L + ++ LPPE+
Sbjct: 783 GLVVEEDLFNTLPPEV 798
Score = 112 bits (280), Expect = 3e-24
Identities = 105/364 (28%), Positives = 163/364 (44%), Gaps = 35/364 (9%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
L +P+ ++ LE L L+ +P +L L++L L + P +A +
Sbjct: 435 LSGIPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRE 493
Query: 84 -LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR-----LPDGFTQLRSLAHLALND 137
L L + DI EIP I K LE +GN + + DG +L+ L L L
Sbjct: 494 NLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS 553
Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195
+L LP V ++ +L L + K + SL + L +L+L DLE +P ++ +
Sbjct: 554 -NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFS 612
Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
L NL+E+ L N L + + +L RL CL + N + +P ++G L L L L++N
Sbjct: 613 LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
+ ++P + C L L L+ N L LP +G L
Sbjct: 673 KIEKIPTQLFY-----------------------CRKLRYLDLSHNNLTFLPADIGLLQN 709
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
L NL + N +E LPPE+ C L L L +N L LP + T L +++ GNRL+ L
Sbjct: 710 LQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECL 769
Query: 374 PFAL 377
P L
Sbjct: 770 PVEL 773
Score = 104 bits (260), Expect = 6e-22
Identities = 84/274 (30%), Positives = 136/274 (49%), Gaps = 14/274 (5%)
Query: 2 LKCIPLWRCNRHVESVDKRHCSLQAVPE-------EIYRYSRSLEELLLDANQLRELPKP 54
+K IPLW + ++++++ H + E + R + L+ L L +N L +LP+
Sbjct: 505 IKEIPLWIYS--LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQV 561
Query: 55 FFRL-LNLRKLGLSDNEIQRLP-PEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADF 112
+ ++L+KL +++ + + + L EL++ R D+ IP SI L+ D
Sbjct: 562 VTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDL 621
Query: 113 SGNPLSRLPD--GFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
N L + + F L L L L + +P +GNL NL L L N ++ +P L
Sbjct: 622 KDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQL 681
Query: 171 SFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSEN 230
+ KL LDL N+L LP +G L NL+ L + N++ LPPEL R+L L + N
Sbjct: 682 FYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
Query: 231 RLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
L+ LP+ +G L LT + L N L LP +G+
Sbjct: 742 VLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
Score = 100 bits (248), Expect = 2e-20
Identities = 66/199 (33%), Positives = 105/199 (52%), Gaps = 5/199 (2%)
Query: 22 CSLQAVPEEIYRYSRSLEELLLDANQLRELPK--PFFRLLNLRKLGLSDNEIQRLPPEVA 79
C L+ +P I+ +L+E+ L N L+ + + F L L L L N I +P ++
Sbjct: 601 CDLERIPHSIFSL-HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 80 NFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139
N L L ++RN I +IP + +C+ L D S N L+ LP L++L +LA+
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199
++ LP ++ L L L N+L+SLP+ + L L Q++L GN LE LP LG P L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 200 RE--LWLDRNQLSALPPEL 216
+ L ++ + + LPPE+
Sbjct: 780 KRSGLVVEEDLFNTLPPEV 798
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 119 bits (298), Expect = 2e-26
Identities = 106/346 (30%), Positives = 165/346 (47%), Gaps = 43/346 (12%)
Query: 21 HCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
H SL + +L+ L L ++ ++P+ F L NL++L LS + PE +
Sbjct: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527
Query: 81 FMQL-----------VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
MQL + L S + IP++ + D G+ L L + ++ +
Sbjct: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586
Query: 130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF--LVKLEQLDLGGNDLE 187
L L L L+ +P + +L NL L+LREN LK++ +SF L L L L N++
Sbjct: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646
Query: 188 VLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTD 247
+P +GAL NL +L LD N + LP +L +L LD+S N L +P E+ L L
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 248 LLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRS 307
++ N + LPDG+ Q C+ L L+L +N LM L
Sbjct: 707 FAVTNNNIEMLPDGLFQ-----------------------CKKLQCLLLGKNSLMNLSPH 743
Query: 308 LGKLTKLTNLNVDRNHLEALPPEIGGCVAL--SVLSLRDNRLAVLP 351
+G+L+ LT+L + N+LE LPPE+ GC +L + L + +N L LP
Sbjct: 744 VGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
Score = 105 bits (262), Expect = 4e-22
Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 14/367 (3%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
L +P+ ++ + +E L L+ +LP +L+NL++L + + + P +A +
Sbjct: 429 LNGLPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE 487
Query: 84 LVE-LDVSRNDIPEIPESIKFCKALEIADFSG----NPLSRLP-DGFTQLRSLAHLALND 137
++ L + ++ +IP + K L+ SG LS + +GF L++L L L
Sbjct: 488 NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS 547
Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGA 195
SL +P V +L +L L L K + + L +V L+ L+L DLE +P ++ +
Sbjct: 548 -SLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS 606
Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
L NL EL L N L + + +L+ L CL + N + +PA++G L L L L N
Sbjct: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
+ LP + +L L + N L + E I NL +T N + LP L + K
Sbjct: 667 NIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKK 726
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL--AHTTELHVLDVAGNRLQ 371
L L + +N L L P +G L+ L L N L LPPEL + + + L V N L
Sbjct: 727 LQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786
Query: 372 SLPFALT 378
+LP +T
Sbjct: 787 TLPLPVT 793
Score = 78.6 bits (192), Expect = 5e-14
Identities = 91/323 (28%), Positives = 142/323 (43%), Gaps = 26/323 (8%)
Query: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175
L+ LPD +L + L+L + LP V L NL L + + L +L+FL +
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
L+ L L ++ +P + L NL+EL+L LP +L ++ D+ R L
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYL 545
Query: 236 PAELGGLV-LLTDLLLSQNLLRRLPDG-----------IGQLKQLSILKVDQNRLCEVTE 283
+ L + ++TDLL S L +G + LK L ++ D R +
Sbjct: 546 KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLER---IPH 602
Query: 284 AIGDCENLSELILTENLLMALPR--SLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
+I NL EL L EN L + S L L+ L + N++ +P +IG L LS
Sbjct: 603 SIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLS 662
Query: 342 LRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTE 401
L N + LP +L T+LH LD++ N L +P + +L+ + N ML
Sbjct: 663 LDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEML----- 717
Query: 402 DDARTGEKVLTCYLLPQQPPLSL 424
D K L C LL + ++L
Sbjct: 718 PDGLFQCKKLQCLLLGKNSLMNL 740
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 119 bits (298), Expect = 2e-26
Identities = 106/346 (30%), Positives = 165/346 (47%), Gaps = 43/346 (12%)
Query: 21 HCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
H SL + +L+ L L ++ ++P+ F L NL++L LS + PE +
Sbjct: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527
Query: 81 FMQL-----------VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
MQL + L S + IP++ + D G+ L L + ++ +
Sbjct: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586
Query: 130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF--LVKLEQLDLGGNDLE 187
L L L L+ +P + +L NL L+LREN LK++ +SF L L L L N++
Sbjct: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646
Query: 188 VLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTD 247
+P +GAL NL +L LD N + LP +L +L LD+S N L +P E+ L L
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 248 LLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRS 307
++ N + LPDG+ Q C+ L L+L +N LM L
Sbjct: 707 FAVTNNNIEMLPDGLFQ-----------------------CKKLQCLLLGKNSLMNLSPH 743
Query: 308 LGKLTKLTNLNVDRNHLEALPPEIGGCVAL--SVLSLRDNRLAVLP 351
+G+L+ LT+L + N+LE LPPE+ GC +L + L + +N L LP
Sbjct: 744 VGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
Score = 105 bits (262), Expect = 4e-22
Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 14/367 (3%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
L +P+ ++ + +E L L+ +LP +L+NL++L + + + P +A +
Sbjct: 429 LNGLPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE 487
Query: 84 LVE-LDVSRNDIPEIPESIKFCKALEIADFSG----NPLSRLP-DGFTQLRSLAHLALND 137
++ L + ++ +IP + K L+ SG LS + +GF L++L L L
Sbjct: 488 NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS 547
Query: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGA 195
SL +P V +L +L L L K + + L +V L+ L+L DLE +P ++ +
Sbjct: 548 -SLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS 606
Query: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
L NL EL L N L + + +L+ L CL + N + +PA++G L L L L N
Sbjct: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666
Query: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
+ LP + +L L + N L + E I NL +T N + LP L + K
Sbjct: 667 NIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKK 726
Query: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL--AHTTELHVLDVAGNRLQ 371
L L + +N L L P +G L+ L L N L LPPEL + + + L V N L
Sbjct: 727 LQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786
Query: 372 SLPFALT 378
+LP +T
Sbjct: 787 TLPLPVT 793
Score = 78.6 bits (192), Expect = 5e-14
Identities = 91/323 (28%), Positives = 142/323 (43%), Gaps = 26/323 (8%)
Query: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175
L+ LPD +L + L+L + LP V L NL L + + L +L+FL +
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
L+ L L ++ +P + L NL+EL+L LP +L ++ D+ R L
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYL 545
Query: 236 PAELGGLV-LLTDLLLSQNLLRRLPDG-----------IGQLKQLSILKVDQNRLCEVTE 283
+ L + ++TDLL S L +G + LK L ++ D R +
Sbjct: 546 KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLER---IPH 602
Query: 284 AIGDCENLSELILTENLLMALPR--SLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
+I NL EL L EN L + S L L+ L + N++ +P +IG L LS
Sbjct: 603 SIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLS 662
Query: 342 LRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTE 401
L N + LP +L T+LH LD++ N L +P + +L+ + N ML
Sbjct: 663 LDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEML----- 717
Query: 402 DDARTGEKVLTCYLLPQQPPLSL 424
D K L C LL + ++L
Sbjct: 718 PDGLFQCKKLQCLLLGKNSLMNL 740
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 117 bits (292), Expect = 1e-25
Identities = 75/228 (32%), Positives = 116/228 (50%), Gaps = 4/228 (1%)
Query: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
+ L G + +P LG LP L+ L L N + + PEL NL +L L++ N LEE+P E
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
Query: 239 LGGLVLLTDLLLSQNLLRRL-PDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILT 297
+ L L +L LS N + R P L+ L +L ++ N L ++ + + ++L+ + +
Sbjct: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
Query: 298 ENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHT 357
N L ++PR L L L L ++ N L +P EI L L L N + VLP EL
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
Query: 358 TELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ---AQPMLRFQTED 402
+L +LD+AGN +Q P L L+ + N QP++ Q E+
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQEN 246
Score = 111 bits (278), Expect = 5e-24
Identities = 75/247 (30%), Positives = 128/247 (51%), Gaps = 8/247 (3%)
Query: 41 LLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPES 100
+ L+ ++ ++P +L L+ L L +N I ++ PE+ N QL L++ N + E+PE
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
Query: 101 IKFCKALEIADFSGNPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELR 159
+K+ +L+ SGN + R G L++L L LN+ L LP +V L +L + +
Sbjct: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
Query: 160 ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNL 219
N L S+P L FL L +L L N L +P+ + L L++L L RN + LP EL +L
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
Query: 220 RRLVCLDVSENRLEELPAELGGLVLL------TDLLLSQNLLRRLPDGIGQLKQLSILKV 273
++L LD++ N ++ P+ L L L L Q ++ + + L++++ V
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFV 258
Query: 274 DQNRLCE 280
N+L E
Sbjct: 259 -MNQLAE 264
Score = 94.4 bits (233), Expect = 8e-19
Identities = 68/228 (29%), Positives = 110/228 (48%), Gaps = 2/228 (0%)
Query: 105 KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLK 164
K +I +G ++++P +L L L L + + + ++ NL L TL L NLL+
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
Query: 165 SLPASLSFLVKLEQLDLGGNDL-EVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLV 223
+P + +L L+ L L GN + P L NL L L+ N L+ LP E+ L+ L
Sbjct: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
Query: 224 CLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
+ ++ N+L +P EL L L +L L+ N L +P+ I LK+L L + +N + + E
Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPE 193
Query: 284 AIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
+ D + L L + N++ P L KL + N L P I
Sbjct: 194 ELCDLKKLRILDIAGNIIQIFPSGFQDL-KLREFYCEGNPLFLQQPVI 240
Score = 84.3 bits (207), Expect = 9e-16
Identities = 62/208 (29%), Positives = 99/208 (47%), Gaps = 1/208 (0%)
Query: 60 NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 119
N + + L+ ++ ++P + L L + N IP++ + L + N L
Sbjct: 15 NTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEE 74
Query: 120 LPDGFTQLRSLAHLALNDVSL-QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQ 178
+P+ L SL +L L+ + + PG L NL+ L L N L LP +S L L
Sbjct: 75 VPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTY 134
Query: 179 LDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE 238
+ + N L +P L L NL EL L+ NQL +P E+ L++L L ++ N + LP E
Sbjct: 135 MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEE 194
Query: 239 LGGLVLLTDLLLSQNLLRRLPDGIGQLK 266
L L L L ++ N+++ P G LK
Sbjct: 195 LCDLKKLRILDIAGNIIQIFPSGFQDLK 222
Score = 59.3 bits (142), Expect = 3e-08
Identities = 35/105 (33%), Positives = 60/105 (57%), Gaps = 1/105 (0%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
L +P+E+ R +SL + ++ NQL +P+ L NL +L L+ N++ +P E+ +
Sbjct: 119 LTQLPQEVSRL-KSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKK 177
Query: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLR 128
L +L ++RN+I +PE + K L I D +GN + P GF L+
Sbjct: 178 LQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222
Score = 55.5 bits (132), Expect = 4e-07
Identities = 44/151 (29%), Positives = 68/151 (45%), Gaps = 25/151 (16%)
Query: 266 KQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLE 325
K I+ ++ ++ ++ A+G L L+L NL+ + L LT+LT LN+ N LE
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
Query: 326 ALPPEI---------------------GGCVALS---VLSLRDNRLAVLPPELAHTTELH 361
+P E+ G C L +L+L +N L LP E++ L
Sbjct: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
Query: 362 VLDVAGNRLQSLPFALTHL-NLKALWLAENQ 391
+ + N+L S+P L L NL L L NQ
Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQ 164
Score = 46.2 bits (108), Expect = 3e-04
Identities = 26/88 (29%), Positives = 46/88 (52%)
Query: 283 EAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSL 342
+A+ +N + L + +P +LGKL L L + N + + PE+ L+ L+L
Sbjct: 8 KALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNL 67
Query: 343 RDNRLAVLPPELAHTTELHVLDVAGNRL 370
+N L +P E+ + T L L ++GNR+
Sbjct: 68 GNNLLEEVPEEMKYLTSLKNLHLSGNRI 95
Score = 43.1 bits (100), Expect = 0.002
Identities = 33/94 (35%), Positives = 49/94 (52%), Gaps = 2/94 (2%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
L ++P E+ + +L EL L+ NQL +P+ L L+KL L+ N I LP E+ + +
Sbjct: 142 LASIPRELC-FLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKK 200
Query: 84 LVELDVSRNDIPEIPESIKFCKALEIADFSGNPL 117
L LD++ N I P + K E GNPL
Sbjct: 201 LRILDIAGNIIQIFPSGFQDLKLREFY-CEGNPL 233
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 116 bits (290), Expect = 2e-25
Identities = 88/225 (39%), Positives = 113/225 (50%), Gaps = 9/225 (4%)
Query: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL--ELRENL-------LKSL 166
PL L F +L + L + +L LP + L +LV + R+ L L +L
Sbjct: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
Query: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
PA LS L L LDL N LE LP + + L L L N LS LP LG L L L
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
Query: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIG 286
V+ NRL+ LP LG L L L LSQNLL LP IG L L L + NRL + ++
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
Query: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
+L L+L NLL ++P L +L LT L++ N L LPPE+
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 115 bits (287), Expect = 5e-25
Identities = 100/263 (38%), Positives = 127/263 (48%), Gaps = 20/263 (7%)
Query: 114 GNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171
GN LS P G QL HL + LQ L + L+ +L E L LP SLS
Sbjct: 35 GNRLSLDLYPGGCQQL---LHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLS 90
Query: 172 FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR 231
L L L G DTLGA R L+ LP L L L LD+S N
Sbjct: 91 CL---RSLVLKGGQRR---DTLGACL--------RGALTNLPAGLSGLAHLAHLDLSFNS 136
Query: 232 LEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENL 291
LE LPA + + L LLLS N L LP+ +G L L+ L V NRL + A+G L
Sbjct: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196
Query: 292 SELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351
L L++NLL LP +G L L LN+ N L++LP + G +L +L L N LA +P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 352 PELAHTTELHVLDVAGNRLQSLP 374
+LA L LD+ N+L+ LP
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLP 279
Score = 106 bits (265), Expect = 2e-22
Identities = 69/171 (40%), Positives = 95/171 (55%)
Query: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176
L+ LP G + L LAHL L+ SL+ LP V + L L L N L LP +L L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
L + N L+ LP LGAL L+ L L +N L LPPE+G L L+ L+++ NRL+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
A L GL L L+L NLL +P + +L L+ L + N+L ++ + D
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
Score = 103 bits (258), Expect = 1e-21
Identities = 95/274 (34%), Positives = 128/274 (46%), Gaps = 29/274 (10%)
Query: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DL 186
R+L L N +SL PG L +L + + L+++E L L + D
Sbjct: 28 RALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ------------LLQVEFLRLSTHEDP 75
Query: 187 EVLPDTLGALPN----LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
++L TL LP LR L L G RR L LPA L GL
Sbjct: 76 QLLEATLAQLPQSLSCLRSLVLK-----------GGQRRDTLGACLRGALTNLPAGLSGL 124
Query: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
L L LS N L LP + Q++ L L + N L E+ EA+G L+ L +T N L
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362
LP +LG L+ L L++ +N L+ LPPEIGG +L L+L NRL LP LA L +
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
Query: 363 LDVAGNRLQSLPFALTHLN-LKALWLAENQAQPM 395
L + N L S+P L L L L L +NQ + +
Sbjct: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDL 278
Score = 99.4 bits (246), Expect = 3e-20
Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 10/225 (4%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE---------IQRL 74
LQ + E R S + LL+A L +LP+ L +L G + + L
Sbjct: 59 LQLLQVEFLRLSTHEDPQLLEAT-LAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
Query: 75 PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134
P ++ L LD+S N + +P + + L S N LS LP+ L +L L
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
Query: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
+ LQ LP +G L+ L L+L +NLL +LP + L L +L+L N L+ LP +L
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
Query: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239
L +LR L L N L+++P +L L L LD+ +N+L +LP EL
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 97.8 bits (242), Expect = 7e-20
Identities = 77/221 (34%), Positives = 103/221 (46%), Gaps = 9/221 (4%)
Query: 48 LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND---------IPEIP 98
L+ L F RL L + + +LP ++ LV R D + +P
Sbjct: 59 LQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLP 118
Query: 99 ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLEL 158
+ L D S N L LP Q+R L L L+ L LP +G L L L +
Sbjct: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178
Query: 159 RENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218
N L++LP +L L L++LDL N L+ LP +G L +L EL L N+L +LP L
Sbjct: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
Query: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
LR L L + N L +PA+L L LLT L L N LR LP
Sbjct: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 77.8 bits (190), Expect = 8e-14
Identities = 62/178 (34%), Positives = 80/178 (44%), Gaps = 3/178 (1%)
Query: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
L L L N L LP ++ L L LS N + LP + L L V+ N + +
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 98 PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLE 157
P ++ L+ D S N L LP L SL L L LQ+LP + L +L L
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
Query: 158 LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
L NLL S+PA L+ L L +LDL N L LP L P +R L N L P+
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGNPLGEASPD 301
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 116 bits (290), Expect = 2e-25
Identities = 88/225 (39%), Positives = 113/225 (50%), Gaps = 9/225 (4%)
Query: 116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL--ELRENL-------LKSL 166
PL L F +L + L + +L LP + L +LV + R+ L L +L
Sbjct: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
Query: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
PA LS L L LDL N LE LP + + L L L N LS LP LG L L L
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
Query: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIG 286
V+ NRL+ LP LG L L L LSQNLL LP IG L L L + NRL + ++
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
Query: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
+L L+L NLL ++P L +L LT L++ N L LPPE+
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 115 bits (287), Expect = 5e-25
Identities = 100/263 (38%), Positives = 127/263 (48%), Gaps = 20/263 (7%)
Query: 114 GNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLS 171
GN LS P G QL HL + LQ L + L+ +L E L LP SLS
Sbjct: 35 GNRLSLDLYPGGCQQL---LHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLS 90
Query: 172 FLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENR 231
L L L G DTLGA R L+ LP L L L LD+S N
Sbjct: 91 CL---RSLVLKGGQRR---DTLGACL--------RGALTNLPAGLSGLAHLAHLDLSFNS 136
Query: 232 LEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENL 291
LE LPA + + L LLLS N L LP+ +G L L+ L V NRL + A+G L
Sbjct: 137 LETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTL 196
Query: 292 SELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351
L L++NLL LP +G L L LN+ N L++LP + G +L +L L N LA +P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 352 PELAHTTELHVLDVAGNRLQSLP 374
+LA L LD+ N+L+ LP
Sbjct: 257 ADLARLPLLTRLDLRDNQLRDLP 279
Score = 106 bits (265), Expect = 2e-22
Identities = 69/171 (40%), Positives = 95/171 (55%)
Query: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKL 176
L+ LP G + L LAHL L+ SL+ LP V + L L L N L LP +L L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 177 EQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELP 236
L + N L+ LP LGAL L+ L L +N L LPPE+G L L+ L+++ NRL+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 237 AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
A L GL L L+L NLL +P + +L L+ L + N+L ++ + D
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
Score = 103 bits (258), Expect = 1e-21
Identities = 95/274 (34%), Positives = 128/274 (46%), Gaps = 29/274 (10%)
Query: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGN-DL 186
R+L L N +SL PG L +L + + L+++E L L + D
Sbjct: 28 RALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQ------------LLQVEFLRLSTHEDP 75
Query: 187 EVLPDTLGALPN----LRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGL 242
++L TL LP LR L L G RR L LPA L GL
Sbjct: 76 QLLEATLAQLPQSLSCLRSLVLK-----------GGQRRDTLGACLRGALTNLPAGLSGL 124
Query: 243 VLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM 302
L L LS N L LP + Q++ L L + N L E+ EA+G L+ L +T N L
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 303 ALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHV 362
LP +LG L+ L L++ +N L+ LPPEIGG +L L+L NRL LP LA L +
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
Query: 363 LDVAGNRLQSLPFALTHLN-LKALWLAENQAQPM 395
L + N L S+P L L L L L +NQ + +
Sbjct: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDL 278
Score = 99.4 bits (246), Expect = 3e-20
Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 10/225 (4%)
Query: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNE---------IQRL 74
LQ + E R S + LL+A L +LP+ L +L G + + L
Sbjct: 59 LQLLQVEFLRLSTHEDPQLLEAT-LAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
Query: 75 PPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134
P ++ L LD+S N + +P + + L S N LS LP+ L +L L
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
Query: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLG 194
+ LQ LP +G L+ L L+L +NLL +LP + L L +L+L N L+ LP +L
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
Query: 195 ALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAEL 239
L +LR L L N L+++P +L L L LD+ +N+L +LP EL
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 97.8 bits (242), Expect = 7e-20
Identities = 77/221 (34%), Positives = 103/221 (46%), Gaps = 9/221 (4%)
Query: 48 LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND---------IPEIP 98
L+ L F RL L + + +LP ++ LV R D + +P
Sbjct: 59 LQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLP 118
Query: 99 ESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLEL 158
+ L D S N L LP Q+R L L L+ L LP +G L L L +
Sbjct: 119 AGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTV 178
Query: 159 RENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGN 218
N L++LP +L L L++LDL N L+ LP +G L +L EL L N+L +LP L
Sbjct: 179 THNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAG 238
Query: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLP 259
LR L L + N L +PA+L L LLT L L N LR LP
Sbjct: 239 LRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 77.8 bits (190), Expect = 8e-14
Identities = 62/178 (34%), Positives = 80/178 (44%), Gaps = 3/178 (1%)
Query: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
L L L N L LP ++ L L LS N + LP + L L V+ N + +
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 98 PESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLE 157
P ++ L+ D S N L LP L SL L L LQ+LP + L +L L
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
Query: 158 LRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
L NLL S+PA L+ L L +LDL N L LP L P +R L N L P+
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---LQGNPLGEASPD 301
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,909,525
Number of Sequences: 37866
Number of extensions: 4716220
Number of successful extensions: 77809
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 907
Number of HSP's successfully gapped in prelim test: 1510
Number of HSP's that attempted gapping in prelim test: 34724
Number of HSP's gapped (non-prelim): 27775
length of query: 1630
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1514
effective length of database: 13,855,062
effective search space: 20976563868
effective search space used: 20976563868
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.